Glucagon and insulin responses to alpha-adrenergic subtype receptor blockade in sheep.
1. Five sheep were used to investigate the influences of alpha-adrenergic subtype receptor blockade on the secretion of both glucagon and insulin. 2. The glucagon secretion was stimulated through an alpha 2-adrenergic subtype mechanism. 3. The secretion of insulin was inhibited by an alpha 2-adrenergic subtype mechanism in conscious sheep.
Oda
S
S
Laboratory of Animal Physiology, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Ohneda
A
A
Tsuda
T
T
Sasaki
Y
Y
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005934:Glucagon / Q000378:metabolism*; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000502:physiology*; D012756:Sheep / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D007328:Insulin; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D005934:Glucagon; D011433:Propranolol; D011224:Prazosin; D004837:Epinephrine