Ciprofloxacin does not impair the elimination of diazepam in humans.
The pharmacokinetics of a single iv dose of 10 mg diazepam and the renal excretion of its metabolites resulting from N-demethylation and C-3-hydroxylation were investigated in 10 healthy volunteers when diazepam was administered alone and on day 3 of administration of the fluoroquinolone ciprofloxacin (500 mg twice per day). No significant changes in the diazepam half-life, its volume of distribution, the total body clearance, or the renal clearance were observed. In addition, the renal excretion of the metabolites desmethyldiazepam, 3-hydroxydiazepam (temazepam), and 3-hydroxydesmethyldiazepam (oxazepam) were not altered by ciprofloxacin co-medication. These data demonstrate that in a 500 mg twice per day oral dosage, ciprofloxacin does not influence the metabolic clearance of diazepam in young healthy volunteers.
Wijnands
W J
WJ
Department of Pulmonary Diseases, Foundation of Deventer Hospitals, The Netherlands.
Trooster
J F
JF
Teunissen
P C
PC
Cats
H A
HA
Vree
T B
TB
D000328:Adult; D002939:Ciprofloxacin / Q000009:adverse effects / Q000494:pharmacology*; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000097:blood
D002939:Ciprofloxacin; D003708:Nordazepam; D003975:Diazepam