[Role of vagus nerve for release of gut hormones].
The role of vagus nerve for release of gastrin, secretin and somatostatin in dogs was studied. Bilateral cervical vagotomy and electric vagal stimulation (25 V 0.5 msec 10 Hz) were performed and blood levels of gut hormones were measured. After vagotomy, blood levels of gastrin, secretin and somatostatin did not change. The electric vagal stimulation elevated blood level of gastrin. Atropine and hexamethonium inhibited the elevation. The electric vagal stimulation did not change blood levels of secretin and somatostatin. In conclusion, vagal stimulation releases gastrin into blood circulation depending on the cholinergic mechanism.
Monguchi
S
S
Second Department of Surgery, School of Medicine, Yokohama City University.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005755:Gastrins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D012633:Secretin / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D013004:Somatostatin