Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia.
Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1.
Schulz
T F
TF
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Whitby
D
D
Hoad
J G
JG
Corrah
T
T
Whittle
H
H
Weiss
R A
RA
D000328:Adult; D000595:Amino Acid Sequence; D006800:Deltaretrovirus Infections / Q000382:microbiology; D005260:Female; D005714:Gambia; D005814:Genes, Viral; D014644:Genetic Variation; D015498:HIV-2 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D012689:Sequence Homology, Nucleic Acid; D014779:Virus Replication