Identification of an infectious laryngotracheitis virus equivalent to the herpes simplex virus type 2 major DNA binding protein (ICP8).
A region of homology between the genomic DNA of infectious laryngotracheitis virus (ILTV), an avian herpesvirus, and the region encoding the herpes simplex virus type 2 (HSV-2) major DNA binding protein (ICP8) has been detected by the use of nick translation and Southern blot analysis. Further, a monoclonal antibody directed against the HSV-2 ICP8 protein detected has antigenic cross-reaction with ILTV as demonstrated by indirect immunofluorescence.
Sheppard
M
M
CSIRO, Division of Animal Health Research Laboratory, Parkville, Australia.
York
J J
JJ
D000818:Animals; D000911:Antibodies, Monoclonal; D003429:Cross Reactions; D004279:DNA, Viral / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D001352:Herpesvirus 1, Gallid / Q000235:genetics* / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid; D018139:Simplexvirus / Q000235:genetics* / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics* / Q000276:immunology
D000911:Antibodies, Monoclonal; D004279:DNA, Viral; D004268:DNA-Binding Proteins; C045462:ICP8 protein, Simplexvirus; D014764:Viral Proteins