Effect of epidermal growth factor (EGF) on gluconeogenesis in isolated rat hepatocytes. Dependency on the red-ox state of the substrate.
It was found that EGF decreased both the basal- and the glucagon-stimulated gluconeogenesis from lactate alone or from a high lactate/pyruvate ratio and that it enhanced both the basal- and the glucagon-inhibited glucose synthesis from pyruvate alone or from a low lactate/pyruvate ratio. These findings demonstrate that the effect of both EGF and glucagon on glucose production by isolated hepatocytes depends on the red-ox state of the substrate.
Soler
C
C
Department de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
Poveda
B
B
Pastor-Anglada
M
M
Soley
M
M
D000818:Animals; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005934:Glucagon / Q000037:antagonists & inhibitors*; D005943:Gluconeogenesis / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D006023:Glycoproteins; D007773:Lactates; D011773:Pyruvates; D004815:Epidermal Growth Factor; D005934:Glucagon; D005947:Glucose