Bilateral regulation of glutamate tissue and extracellular levels in caudate-putamen by midbrain dopamine neurons.
Tissue levels and in vivo release of glutamate were measured in caudate-putamen of rat brain after a unilateral 6-hydroxydopamine lesion of meso-striatal/meso-cortico-limbic dopamine neurons. The results were compared with glutamate levels from corresponding regions in sham-injected animals. The unilateral dopamine lesion induced a bilateral increase of tissue levels of glutamate (45% ipsilateral and 39% contralateral to the lesion). Extracellular levels of glutamate as measured by microdialysis were also bilaterally increased (107% ipsilateral and 94% contralateral to the lesion). The results indicate that mesencephalic dopamine neurons regulate neuronal glutamate in ipsilateral as well as contralateral caudate-putamen.
Lindefors
N
N
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Ungerstedt
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U
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006892:Hydroxydopamines; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D006892:Hydroxydopamines; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D016627:Oxidopamine; D004298:Dopamine