title: Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols.
abstract: A series of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the best antiarrhythmic agents in this series and was essential for long duration of action. This investigation indicated that quaternary ammonium salts were not essential for a long duration of action. It was also shown that the antiarrhythmic activity could be separated from the tachycardia frequently caused by this type of agent.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
authors.forename: M L
authors.initials: ML
authors.lastname: Hoefle
authors.forename: L T
authors.initials: LT
authors.lastname: Blouin
authors.forename: R W
authors.initials: RW
authors.lastname: Fleming
authors.forename: S
authors.initials: S
authors.lastname: Hastings
authors.forename: J M
authors.initials: JM
authors.lastname: Hinkley
authors.forename: T E
authors.initials: TE
authors.lastname: Mertz
authors.forename: T J
authors.initials: TJ
authors.lastname: Steffe
authors.forename: C S
authors.initials: CS
authors.lastname: Stratton
authors.forename: L M
authors.initials: LM
authors.lastname: Werbel
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000889:Anti-Arrhythmia Agents; D001593:Benzyl Compounds; D010880:Piperidines