Neuropsychological effects of carbamazepine and phenytoin: a reanalysis.
We previously reported that carbamazepine had fewer adverse neuropsychological effects than phenytoin, but it is now clear that our patients had much higher phenytoin than carbamazepine serum levels. When persons with high initial phenytoin levels were excluded, the statistical significance of all neuropsychological differences between the drugs disappeared.
Dodrill
C B
CB
Regional Epilepsy Center, University of Washington, School of Medicine, Seattle.
Troupin
A S
AS
D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D009483:Neuropsychological Tests; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood; D011619:Psychotropic Drugs / Q000009:adverse effects*; D014888:Wechsler Scales
D011619:Psychotropic Drugs; D002220:Carbamazepine; D010672:Phenytoin