title: Antibodies to interleukin-1 inhibit cytokine-induced proliferation of neonatal rat Schwann cells in vitro.
abstract: Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced by unfractionated human cytokines whereas antibodies to interleukin-2 (IL-2) and control IgG did not. However, purified human IL-1 and recombinant human IL-1 alpha or beta did not induce Schwann cell proliferation on their own.
authors.affiliation: Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201.
authors.forename: R P
authors.initials: RP
authors.lastname: Lisak
authors.forename: B
authors.initials: B
authors.lastname: Bealmear
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D016207:Cytokines / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology; D007375:Interleukin-1 / Q000276:immunology*; D008362:Mannosides / Q000494:pharmacology; D008766:Methylmannosides; D051381:Rats; D012583:Schwann Cells / Q000166:cytology*
chemical_list: D000906:Antibodies; D016207:Cytokines; D007375:Interleukin-1; D008362:Mannosides; D008766:Methylmannosides; D003208:Concanavalin A; C008466:methylmannoside