[The role of the serum interleukin-2 inhibitor in the rejection of allogeneic hematopoietic tissue in sublethally irradiated mice].
The influence of ionizing radiation (5 Gy) on the interleukin-2 inhibitor in mouse serum has been investigated. It has been shown that the concentration of IL-2 inhibitor decreases on days 3-6 and increases considerably on days 10-15 after irradiation. A correlation has been found between the number of T-helpers in spleens of exposed allogenic chimeras and low IL-2 inhibitor content of serum. An attempt has been made to use the increased IL-2 inhibitor level for improving the acceptance of allogenic cells in the sublethally exposed mice.
Svirshchevskaia
E V
EV
Dozmorov
I M
IM
Moiseeva
E V
EV
D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D007376:Interleukin-2 / Q000037:antagonists & inhibitors*; D008222:Lymphokines / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000276:immunology*
D007376:Interleukin-2; D008222:Lymphokines; C046147:interleukin 2 inhibitor