[Effect of thymic immunomodulators on the system of cyclic nucleotides of splenic T-lymphocytes after BCG vaccination].
The experiments on guinea pigs was performed to study the effects of thymogen , thymalin and vilosene on the activity of cAMP, cGMP, adenylate cyclase, guanylate cyclase, cAMP- and cGMP-phosphodiesterases in T lymphocytes during BCG vaccination. It was shown that the disease was accompanied by increased activity of enzymes of anabolism and catabolism of cyclic nucleotides. Thymogen and thymalin mainly activated the synthesis of cGMP, thus causing the shift of cAMP/cGMP value below the reference level. At the same time vilosene increased this value in the process of a repeated BCG injection.
Demidov
S V
SV
Kostromin
A P
AP
Chernyshenko
E F
EF
Kuĭbeda
V V
VV
Borovok
M I
MI
D000262:Adenylyl Cyclases / Q000378:metabolism; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004151:Dipeptides; D006162:Guanylate Cyclase / Q000378:metabolism; D006168:Guinea Pigs; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D013951:Thymus Hormones / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D004151:Dipeptides; D010455:Peptides; D013951:Thymus Hormones; C060736:thymogen; C032805:thymalin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP