Synthesis, peroxidating ability, and antineoplastic evaluation of 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones.
A novel group of cytotoxic anthraquinone derivatives, 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones, has been synthesized. It has been shown that imino analogues of the anthracenediones exhibit diminished ability to generate oxygen radicals. The cytotoxic activity of iminoanthracenones obtained was lower than that of the related quinone carbonyl analogues. One of the obtained imino compounds showed a moderate antileukemic activity in vivo.
Dzieduszycka
M
M
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
Martelli
S
S
Tarasiuk
J
J
Paradziej-Lukowicz
J
J
Borowski
E
E
D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D046508:Culture Techniques; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice
D000873:Anthracenes; D000970:Antineoplastic Agents