Trisomy 8 as a nonrandom secondary change in myxoid liposarcoma.
We report the cytogenetic findings in 5 cases of myxoid liposarcoma following short-term culture. In all 5 tumors a t(12:16)(q13:p11), characteristic of the myxoid form of liposarcoma, was observed. Trisomy 8 was present in two tumors as the only additional change and in a third in addition to other abnormalities. In the other two tumors the t(12:16) was present as the sole change. Three other myxoid liposarcomas with trisomy 8 as an additional aberration have been reported, suggesting that it could represent a non-random secondary event in these tumors.
Sreekantaiah
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C
Cancer Center of Southwest Biomedical Research Institute of Genetrix, Scottsdale, Arizona 85251.
Karakousis
C P
CP
Leong
S P
SP
Sandberg
A A
AA
D000328:Adult; D000368:Aged; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy