Neutrophil alkaline phosphatase activity in the urinary neutrophils of a patient with chronic myelogenous leukemia.
We report here a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) in chronic phase in whom the alkaline phosphatase activity of neutrophils in the peripheral blood was low while at the same time the alkaline phosphatase content of neutrophils present in the urine was elevated. This observation provides independent clinical support for the recent experimental finding that an extrinsic factor (granulocyte colony-stimulating factor) controls alkaline phosphatase expression in human neutrophils.
Janković
G
G
Institute of Hematology, University Clinical Center, Faculty of Medicine, Belgrade, Yugoslavia.
Petrović
M
M
Colović
M
M
Zilić
M
M
Dotlić
R
R
D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001773:Blood Cells / Q000201:enzymology*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology*; D009504:Neutrophils / Q000201:enzymology*; D014556:Urine / Q000166:cytology*
D000469:Alkaline Phosphatase