Chromosome assignment of four RAS-related RAB genes.
The human RAB genes share structural and biochemical properties with the RAS gene superfamily. The encoded RAB proteins show 38 to 75% amino acid identity with the yeast YPT1 and SEC4 gene products. We used four human RAB-cDNAs, RAB3B, RAB4, RAB5 and RAB6, to map the corresponding genes on human chromosomes. These genes were assigned to 1p32-p31, 1q42-q43, 3p24-p22 and 2q14-q21, respectively, by in situ hybridization.
Rousseau-Merck
M F
MF
INSERM U.301, Institut de Génétique Moléculaire, Paris, France.
Zahraoui
A
A
Touchot
N
N
Tavitian
A
A
Berger
R
R
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D011905:Genes, ras; D006801:Humans; D005810:Multigene Family; D011519:Proto-Oncogenes