Uric acid as an inhibitor of cyclophosphamide-induced micronuclei in mice.
Swiss albino male mice, 6-8 weeks old, were treated orally with different doses of uric acid dissolved in water for 7 days. Some of the mice in each group were injected i.p. with cyclophosphamide (25 mg/kg) and killed after 30 h. The blood of all animals was analyzed for uric acid levels. The femoral cells of the mice in different groups were collected and studied. Uric acid was found to be devoid of mitodepressant or clastogenic activity at 10-100 mg/kg/day. Pretreatment with uric acid was found to provide significant protection against cyclophosphamide-induced bone marrow depression and micronucleated polychromatic erythrocytes.
al-Bekairi
A M
AM
Experimental Animal Care Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Qureshi
S
S
Chaudhry
M A
MA
Shah
A H
AH
D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009154:Mutation / Q000187:drug effects*; D014527:Uric Acid / Q000097:blood / Q000494:pharmacology*
D014527:Uric Acid; D003520:Cyclophosphamide