title: A method for in vitro mapping of ultrasonic speed and density in breast tissue.
abstract: A method has been developed for mapping density and ultrasonic speed in 1 mm thick slices of soft tissue with a resolution of about 1 mm. Tests using phantom sections have verified the accuracy and resolution of the ultrasonic speed maps. The method has been applied to breast tissues of three patients including tumors and surrounding tissue. Fixing a specimen in 5% formaldehyde did not change the degree of local variation in ultrasonic speeds, and raised mean speeds by less than 0.8%. The densities with fixing remained almost unchanged at low tissue densities (0.93 g/cm3), but rose 1.5% for higher tissue density (greater than 1.00 g/cm3).
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison 53706.
authors.forename: J N
authors.initials: JN
authors.lastname: Yang
authors.forename: A D
authors.initials: AD
authors.lastname: Murphy
authors.forename: E L
authors.initials: EL
authors.lastname: Madsen
authors.forename: J A
authors.initials: JA
authors.lastname: Zagzebski
authors.forename: K W
authors.initials: KW
authors.lastname: Gilchrist
authors.forename: G R
authors.initials: GR
authors.lastname: Frank
authors.forename: M C
authors.initials: MC
authors.lastname: Macdonald
authors.forename: C A
authors.initials: CA
authors.lastname: Millard
authors.forename: A
authors.initials: A
authors.lastname: Faraggi
authors.forename: C A
authors.initials: CA
authors.lastname: Jaramillo
mesh_terms: D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008722:Methods; D014465:Ultrasonics; D016217:Ultrasonography, Mammary