Studies on the antiviral activity of inorganic heteropolyanions against Semliki forest virus in vivo and vaccinia virus in vitro.
Seven new inorganic heteropolyanions were tested for their antiviral activity. One of these, sodium 12-tungstoborate, was found to protect mice from Semliki forest virus and mouse embryo fibroblast monolayers from vaccinia virus infections. In mice these heteropolyanions exhibited no synergistic antiviral activity with the interferon inducing mycoviral double-stranded RNA.
George
C X
CX
Division of Microbiology and Biochemistry, Central Drug Research Institute, Lucknow, India.
Singh
C
C
Ram
S N
SN
Yadav
K D
KD
Sharma
B
B
D000818:Animals; D000998:Antiviral Agents; D001881:Borates / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology*; D012672:Semliki forest virus / Q000187:drug effects* / Q000254:growth & development; D014036:Togaviridae Infections / Q000517:prevention & control; D014414:Tungsten / Q000494:pharmacology*; D017973:Tungsten Compounds; D014616:Vaccinia virus / Q000187:drug effects* / Q000254:growth & development; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D001881:Borates; D000071228:Polyelectrolytes; D011108:Polymers; D014414:Tungsten; D017973:Tungsten Compounds; C067587:12-tungstoborate