Quantitative autoradiography of beta-adrenergic receptors in rabbit eyes.
Beta-adrenergic receptors were localized and quantified with autoradiographic methods in frozen sections of eyes of albino rabbits using [125I]cyanopindolol and [3H]dihydroalprenolol. Quantification in albino rabbits revealed highest beta 2-adrenoceptor densities in the ciliary body, the corneal epithelium and the corneal endothelium. Moreover, the iris showed significant amounts of specific binding, whereas the retina and sclera are nearly free of these receptors.
Kahle
G
G
Universitäts-Augenklinik im Klinikum Charlottenburg, Freie Universität Berlin, F.R.G.
Kaulen
P
P
Wollensak
J
J
D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002924:Ciliary Body / Q000737:chemistry; D003315:Cornea / Q000737:chemistry; D004728:Endothelium, Corneal / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry; D005123:Eye / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D005629:Frozen Sections; D007498:Iris / Q000737:chemistry; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; C047975:cyanopindolol; D010869:Pindolol