title: A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi.
abstract: The karyotypes of 144 spontaneous abortuses were determined using direct chromosome preparations from chorionic villi. The frequency of chromosome abnormality was 69.4%, which is considerably higher than figures cited in most previous cytogenetic surveys using the conventional method of cell culturing. Autosomal trisomy was the predominant abnormality (64%), followed by polyploidy (9%), monosomy X (7%), structural rearrangements (6%), mosaicism (6%), double trisomy (4%), and double chromosome anomaly (3%). Direct preparations have advantages in that results can be obtained rapidly, the success rate of karyotyping is satisfactory, and maternal-cell contamination is minimal.
authors.affiliation: Cytogenetics Laboratory, Kitasato University Hospital, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: A
authors.initials: A
authors.lastname: Matsunobu
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D002824:Chorionic Villi / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D016216:Ultrasonography, Prenatal