title: [Effects of the treatment using synthetic LH-RH nasal spray in cryptorchism].
abstract: The effects of hormonal treatment with synthetic LH-RH (Kryptocur) applied as nasal spray at a dose of 1.2 mg daily over a period of 28 days were investigated on 62 undescended testes in 40 boys divided in two groups: below and above 6 years. Only retained testes were treated. Complete descent was achieved primarily in 46.7%, but follow up examination 6 months after therapy showed relapse in 9%, so that percent was reduced to 39.7%. Therapy was more effective in patients with unilateral undescended testes aged below 6 years; however they showed relapse in 33%. Bilateral undescended testes were more sensitive to the treatment (25%) in children aged over 6 years. In these patients we didn't observe relapse. No hormonal changes in FSH, LH and testosterone were observed before and after treatment, whether in basal or in pick after 25 micrograms i.v. of LHRH. 3 boys treated unsuccessfully showed low values of FSH after LHRH test at end of treatment. Treatment of cryptorchidism with intranasal synthetic LH-RH seems to be effective without side effects and painless. For this reason it may be used as attempt before surgery, particularly in boys aged below 6 years.
authors.affiliation: Divisione di Chirurgia pediatrica, Ospedale Salesi, Ancona, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Muzzi
authors.forename: E
authors.initials: E
authors.lastname: Bartolotta
authors.forename: V
authors.initials: V
authors.lastname: Cherubini
authors.forename: D
authors.initials: D
authors.lastname: Lomiento
mesh_terms: D000280:Administration, Inhalation; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000188:drug therapy*; D004341:Drug Evaluation; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D007987:Gonadotropin-Releasing Hormone