Effects of dapiprazole on the reversal of pharmacologically induced mydriasis.
The ability of a new alpha-adrenergic antagonist, dapiprazole, to reverse mydriasis produced by phenylephrine 2.5% or 10%, tropicamide 0.5%, and the combination of phenylephrine 2.5% and tropicamide 0.5% was investigated. A double masked crossover design was used to study both efficacy of mydriatic reversal and time course. The safety of administration was evaluated as well. Subjects were optometry students and their spouses. The results demonstrate that dapiprazole is safe and effective for reversing mydriasis produced by both concentrations of phenylephrine, and partially effective in reversing mydriasis in eyes treated with tropicamide 0.5%, alone, or in combination with 2.5% phenylephrine.
Nyman
N
N
Eye Institute, Pennsylvania College of Optometry, Philadelphia.
Keates
E U
EU
D000065:Accommodation, Ocular / Q000187:drug effects; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009184:Mydriatics / Q000037:antagonists & inhibitors*; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D010879:Piperazines; D011680:Pupil / Q000187:drug effects*; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology* / Q000633:toxicity; D014331:Tropicamide / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D009184:Mydriatics; D010879:Piperazines; D014230:Triazoles; D010656:Phenylephrine; C035289:dapiprazole; D014331:Tropicamide