Potential hazards of long-term acid suppression.
Neuroendocrine cell (carcinoid) tumours have been reported in the acid-secreting part of the stomach of rodents after long-term administration of a range of potent chemically diverse antisecretory agents. Although evidence shows a link between the sequence of acid suppression, hypergastrinaemia, and neuroendocrine cell hyperplasia, other factors are also thought to be involved in neoplastic transformation. Prolonged hypochlorhydria or achlorhydria resulting in bacterial colonization of the stomach may allow the generation of carcinogenic substances. Other as yet unidentified trophic factors may be involved in tumour formation. In view of the potential risks associated with these agents, there must be concern about the possible consequences in man of marked suppression of acid. It seems wise to limit the use of these more potent agents to situations in which conventional therapy has failed and to short-term treatment.
Selway
S A
SA
Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
D000818:Animals; D002276:Carcinoid Tumor / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism* / Q000502:physiology; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D005755:Gastrins / Q000502:physiology; D006635:Histamine H2 Antagonists / Q000494:pharmacology / Q000633:toxicity*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D051379:Mice; D009853:Omeprazole / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000503:physiopathology; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology / Q000633:toxicity
D005755:Gastrins; D006635:Histamine H2 Antagonists; D014230:Triazoles; C039993:loxtidine; D009853:Omeprazole