Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
Broek
D
D
Biochemistry Department, University of Oxford, UK.
Bartlett
R
R
Crawford
K
K
Nurse
P
P
D016203:CDC2 Protein Kinase / Q000502:physiology*; D002453:Cell Cycle; D004261:DNA Replication; D005656:Fungal Proteins / Q000378:metabolism; D008938:Mitosis; D009154:Mutation; D009584:Nitrogen / Q000378:metabolism; D016196:S Phase; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics
D005656:Fungal Proteins; D016203:CDC2 Protein Kinase; D009584:Nitrogen