title: New restriction fragment length polymorphism (probe E9) reveals the highest linkage disequilibrium in Italian CF patients.
abstract: We report that the allele distribution for RFLP's flanking the CF gene differs between patients with and without pancreatic insufficiency. The present study confirms this difference. In both classes the linkage disequilibrium (LD) is highest with the RFLP revealed by probe E9. The haplotype distribution identified by these RFLP's can be used for indirect carrier detection.
authors.affiliation: Laboratorio de Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Devoto
authors.forename: L
authors.initials: L
authors.lastname: De Benedetti
authors.forename: P
authors.initials: P
authors.lastname: Ronchetto
authors.forename: L
authors.initials: L
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: L C
authors.initials: LC
authors.lastname: Tsui
authors.forename: M
authors.initials: M
authors.lastname: Dean
authors.forename: F
authors.initials: F
authors.lastname: Collins
authors.forename: M
authors.initials: M
authors.lastname: Seia
authors.forename: L
authors.initials: L
authors.lastname: Piceni Sereni
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics*; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D015335:Molecular Probes; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers; D015335:Molecular Probes