Analysis of non-disjunction in sex chromosome tetrasomy and pentasomy.
X-linked DNA markers were used to determine the parental origin of the additional sex chromosomes in eight individuals with sex chromosome tetrasomy or pentasomy. In all cases studied, one parent contributed a single sex chromosome while the other parent contributed three or four sex chromosomes. Thus, it seems likely that most, if not all, sex chromosome tetrasomy and pentasomy is attributable to successive non-disjunctional events involving the same parent.
Hassold
T
T
Division of Medical Genetics, Emory University, Atlanta 30322.
Pettay
D
D
May
K
K
Robinson
A
A
D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D009630:Nondisjunction, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011123:Polyploidy; D014960:X Chromosome
D005819:Genetic Markers