title: Factors V and VII anticoagulant activities in the salivary glands of feeding Dermacentor andersoni ticks.
abstract: The salivary glands of Dermacentor andersoni ticks possess anticoagulant activities that can alter the clotting time of rabbit whole blood. Salivary gland extracts from female ticks inhibit both the intrinsic and extrinsic coagulation systems, and maximal activities against both pathways occur when the ticks attain about 250 mg feeding weight. These anticoagulants are directed against both coagulation factors V and VII, but they do not affect factors II or X. Despite this salivary anticoagulant activity, heavily tick-infested rabbits suffer no visible alteration of their peripheral blood coagulability and have no detectable circulating fibrin degradation products, suggesting that the ticks do not secrete a factor with fibrinolytic activity.
authors.affiliation: Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: J R
authors.initials: JR
authors.lastname: Gordon
authors.forename: J R
authors.initials: JR
authors.lastname: Allen
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D003870:Dermacentor / Q000502:physiology*; D005165:Factor V / Q000037:antagonists & inhibitors*; D005167:Factor VII / Q000037:antagonists & inhibitors*; D005260:Female; D007700:Kinetics; D011817:Rabbits; D012469:Salivary Glands / Q000502:physiology
chemical_list: D000925:Anticoagulants; D005165:Factor V; D005167:Factor VII