title: Early asbestosis: evaluation with high-resolution CT.
abstract: To determine the earliest stage at which lesions in asbestosis can be diagnosed and to assess their progression, 23 asbestos-exposed patients with minimal or no abnormalities at plain radiography were examined with high-resolution computed tomography (HRCT) twice, with an interval of 12-37 months between examinations. In 21 of the patients, parenchymal abnormalities were found. Major parenchymal features seen at CT included thickened intralobular and interlobular lines, subpleural curvilinear lines, pleural-based nodular irregularities, hazy patches of increased attenuation, small cystic spaces, and small areas of low attenuation. At paired serial CT, subpleural isolated dots or branching structures connected with the most peripheral branch of the pulmonary artery started to appear in lower subpleural zones and then became confluent to create pleural-based nodular irregularities. CT-pathologic correlation led to the conclusion that the confluence of subpleural peribronchiolar fibrosis creates subpleural fibrosis.
authors.affiliation: Department of Radiology, National Kinki Chuo Hospital for Chest Disease, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akira
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Higashihara
authors.forename: K
authors.initials: K
authors.lastname: Morinaga
authors.forename: N
authors.initials: N
authors.lastname: Kita
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: J
authors.initials: J
authors.lastname: Ikezoe
authors.forename: T
authors.initials: T
authors.lastname: Kozuka
mesh_terms: D000328:Adult; D000368:Aged; D001195:Asbestosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking; D014057:Tomography, X-Ray Computed / Q000379:methods