Cyanide intoxication. II. The effects of systematic cyanide challenge on indicative toxicity parameters.
1. Present studies were carried out to establish the action of cyanide maintained at a high level during a period as long as desired. 2. One of the earliest effects of cyanide seems to be the inhibition of hepatic rhodanese. These changes do not seem to occur in the blood. 3. Available cyanide labile-sulfur was always altered, unless cyanide tissue levels could not be detected. 4. The inhibitory action of cyanide on enzymatic reaction involving Schiff base intermediates was also corroborated through its effect on delta-aminolevulinate acid dehydratase activity. 5. S-Adenosyl-L-methionine was not able to modify the toxic cyanide action.
Buzaleh
A M
AM
Centro de Investigaciones sobre Porfirinas y Porfirias, CIPYP (CONICET, FCE y N, UBA), Ciudad Universitaria, Buenos Aires, Argentina.
Vázquez
E S
ES
Batlle
A M
AM
D000818:Animals; D001921:Brain / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D012436:S-Adenosylmethionine / Q000494:pharmacology; D012545:Schiff Bases / Q000378:metabolism; D013455:Sulfur / Q000378:metabolism; D013884:Thiosulfate Sulfurtransferase / Q000037:antagonists & inhibitors
D012545:Schiff Bases; D013455:Sulfur; D012436:S-Adenosylmethionine; D013884:Thiosulfate Sulfurtransferase; D000623:Porphobilinogen Synthase; D011190:Potassium Cyanide