title: Behavioral genetic analysis of regional mouse brain biogenic amines, acidic metabolites and motor activity.
abstract: 1. Comparative analyses of regional brain biogenic amines and spontaneous locomotor activity of three mouse strains suggest a genotype dependent relationship. 2. A positive correlation between striatal dopamine and locomotor activity was determined in the inbred albino BALB/c mouse strain. 3. An inverse relationship between some brain regions serotonin and motility was found in the inbred black C57BL/6 mouse strain. 4. No correlation could be established between brain monoamines and motor activity in the hybrid CDF-1 mouse strain. 5. The results suggest that inbred BALB/c and C57BL/6 mouse strains may be useful animal models for studying dopaminergic and serotonergic acting agents, respectively.
authors.affiliation: Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.
authors.forename: F S
authors.initials: FS
authors.lastname: Messiha
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000235:genetics*; D013045:Species Specificity
chemical_list: D001679:Biogenic Amines