The HLA-DR beta 16 allogenotype constitutes a risk factor for hypertrophic scarring.
Nineteen patients that had developed hypertrophic scars subsequent to thermal injury were typed for HLA class II allogenotypes with the restriction fragment length polymorphism technique. A significant association was found with DR beta 16 (pc = 1.45 x 10(-4); relative risk = 12.25). This finding adds evidence to other data suggesting that immunologic phenomena are involved in pathologic scarring. Moreover, the results presented here have allowed an identification of a genetically determined risk factor for hypertrophic scar formation located in the HLA region.
Castagnoli
C
C
Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italy.
Peruccio
D
D
Stella
M
M
Magliacani
G
G
Mazzola
G
G
Amoroso
A
A
Richiardi
P
P
D002921:Cicatrix / Q000235:genetics / Q000276:immunology*; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics / Q000502:physiology*; D059810:HLA-DR Serological Subtypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D007519:Isoantigens / Q000502:physiology; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014945:Wound Healing / Q000276:immunology*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C067266:HLA-DR16 antigen; D000949:Histocompatibility Antigens Class II; D007519:Isoantigens