Physiological modulation of renal function by the renal dopaminergic system.
1. The renal dopaminergic system is a potentially important regulator of sodium homeostasis and kidney function. 2. We have presented evidence that dopamine acts as a paracrine substance at DA-1 and DA-2 receptors in the physiological control of renal function. 3. Much more information is required regarding basic cellular mechanisms and the functional regulation of the system so that the role of renal dopamine can be placed clearly in context with other established hormonal regulatory systems.
Carey
R M
RM
Department of Medicine, University of Virginia, School of Medicine, Charlottesville.
Siragy
H M
HM
Felder
R A
RA
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology
D001552:Benzazepines; D015259:Dopamine Agents; D004873:Ergolines; D011954:Receptors, Dopamine; D019257:Quinpirole; D004298:Dopamine