title: Responses of the colonic epithelium to auranofin: evidence for involvement of enteric nerves.
abstract: Auranofin, the orally effective gold compound, stimulated the canine colonic epithelium in vitro. It increased short circuit currents across both the innervated mucosal and functionally "nerve-free" epithelial preparation, when added to either the luminal or serosal solutions. Serosal responses were inhibited by tetrodotoxin (TTX). A hydrophilic gold compound, sodium aurothiosulphate produced similar effects but only on serosal addition. Gold compounds can thus alter colonic transport activating enteric nerves and releasing a neurotransmitter. Thus gold induced diarrhea could have a significant neural component.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: de Beaux
authors.forename: C M
authors.initials: CM
authors.lastname: Keenan
authors.forename: K
authors.initials: K
authors.lastname: Tytgat
authors.forename: P K
authors.initials: PK
authors.lastname: Rangachari
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology; D001310:Auranofin / Q000494:pharmacology*; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003106:Colon / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D004112:Dimercaprol / Q000494:pharmacology; D004187:Disaccharides / Q000494:pharmacology; D004285:Dogs; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D008667:Metalloproteins / Q000494:pharmacology; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D018501:Antirheumatic Agents; D004187:Disaccharides; D008667:Metalloproteins; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; C059555:O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate; D001310:Auranofin; D013779:Tetrodotoxin; D002809:Chondroitin Sulfates; C013394:aurotioprol