Antihistaminic activity of pulegone on the guinea-pig ileum.
Pulegone, a natural monoterpene compound, has an antihistamine effect on guinea-pig ileum. Its antagonism is of the competitive type (PA2 = 6.35) like that of mepyramine and dexchlorpheniramine, two H1-antagonists, with PA2 values of 10.15 and 8.74, respectively.
Ortiz de Urbina
A V
AV
Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
Martin
M L
ML
Montero
M J
MJ
Carron
R
R
Sevilla
M A
MA
San Roman
L
L
D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D000081005:Cyclohexane Monoterpenes; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives* / Q000494:pharmacology; D039821:Monoterpenes; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology
D000081005:Cyclohexane Monoterpenes; D006633:Histamine Antagonists; D039821:Monoterpenes; D008610:Menthol; D002744:Chlorpheniramine; C039648:pulegone; D011738:Pyrilamine