title: Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis.
abstract: A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph + CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.
authors.affiliation: Department of Medical Oncology, University of Pretoria, Republic of South Africa.
authors.forename: S M
authors.initials: SM
authors.lastname: Ansell
authors.forename: B L
authors.initials: BL
authors.lastname: Rapoport
authors.forename: M A
authors.initials: MA
authors.lastname: Coccia-Portugal
authors.forename: K
authors.initials: K
authors.lastname: Stevens
authors.forename: C J
authors.initials: CJ
authors.lastname: Bester
authors.forename: G
authors.initials: G
authors.lastname: Falkson
mesh_terms: D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D014314:Trisomy