Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma. Case report.
A sphenoid-wing meningioma in a 60-year-old woman was accompanied by elevated serum carcinoembryonic antigen (CEA) levels, which returned to normal after removal of the tumor. Light microscopic examination revealed a secretory meningioma containing numerous pseudopsammoma bodies and a prominent vascular pattern. Immunohistochemical analysis showed the tumor cells and pseudopsammoma bodies to be CEA-positive. This case illustrates the possibility that secretory meningioma may be associated with clinically detectable secretion of CEA. The report also documents the rare occurrence of elevated serum CEA in a primary benign intracranial tumor.
Louis
D N
DN
Department of Pathology Massachusetts General Hospital, Harvard Medical School, Boston.
Hamilton
A J
AJ
Sobel
R A
RA
Ojemann
R G
RG
D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008577:Meningeal Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D008579:Meningioma / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged
D002272:Carcinoembryonic Antigen