Kawasaki-like syndrome after treatment with mesalazine.
We report a patient who developed a severe hypersensitivity reaction, including rash, lymph node enlargement, fever, hepatitis, and eosinophilia, after sulphasalazine therapy. Five years later, he developed a similar reaction after exposure to mesalazine, the salicylic compound of sulphasalazine. We conclude that patients with known severe systemic reaction to sulphasalazine therapy are also at risk for such a reaction when treated with a 5-ASA preparation.
Waanders
H
H
University Hospital, Department of Infectious Diseases, Leiden, The Netherlands.
Thompson
J
J
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D019804:Mesalamine; D009080:Mucocutaneous Lymph Node Syndrome / Q000139:chemically induced*; D013577:Syndrome
D000636:Aminosalicylic Acids; D019804:Mesalamine