HLA in bullous pemphigoid. The probable role of HLA-B7 as a marker for poor responders to immunosuppressive therapy.
The frequency of HLA-class I and DR antigen frequencies were studied in 38 (class I) and 19 (DR) patients with bullous pemphigoid, respectively, and compared with controls. There was no important difference in the frequency of HLA-A,B,C, and DR antigens between patients and controls. An increase in the HLA-B7 frequency in poor responders to immunosuppressants (50% vs. 27% in the control group and vs. 13% in the group of all patients) was noticed, and the possible role of this antigen as a marker for poor responders to therapy was suggested.
Schaller
J
J
Department of Dermatology, Leipzig University, School of Medicine, Germany.
Feleke
W
W
Haustein
U F
UF
Baldauf
C
C
Kunze
G
G
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000276:immunology* / Q000628:therapy
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D007166:Immunosuppressive Agents