title: AIDS virus infection and autoimmunity: a perspective of the clinical, immunological, and molecular origins of the autoallergic pathologies associated with HIV disease.
abstract: The acquired immune deficiency syndrome (AIDS) is a viral-induced disorder of humans that is reaching pandemic proportions. The etiologic agent responsible for AIDS is recognized as a retrovirus termed the human immunodeficiency virus (HIV). This virus is both cytotropic and cytopathic for T lymphocytes in vitro, and patients with AIDS and HIV-related conditions invariably have serious T cell abnormalities, notably a reduced number of the helper/inducer (CD4+) subpopulation. There is now a substantial body of evidence to suggest that the AIDS virus triggers a diverse range of autoimmune phenomena. The purpose of this article is to summarize the clinical and immunopathological manifestations of autoimmunity in HIV infection and to provide a perspective of the possible origins and roles autoimmune reactions play in HIV disease progression.
authors.affiliation: IDEC Pharmaceuticals Corporation, La Jolla, California 92037.
authors.forename: W J
authors.initials: WJ
authors.lastname: Morrow
authors.forename: D A
authors.initials: DA
authors.lastname: Isenberg
authors.forename: R E
authors.initials: RE
authors.lastname: Sobol
authors.forename: R B
authors.initials: RB
authors.lastname: Stricker
authors.forename: T
authors.initials: T
authors.lastname: Kieber-Emmons
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000595:Amino Acid Sequence; D015551:Autoimmunity; D006801:Humans; D008969:Molecular Sequence Data