title: Magnesium sulfate decreases maternal blood pressure but not uterine blood flow during epidural anesthesia in gravid ewes.
abstract: The purpose of this study was to determine whether administration of magnesium sulfate decreased maternal blood pressure during epidural anesthesia in gravid ewes. Twenty-two experiments were performed in 11 chronically instrumented animals between 0.8 and 0.9 of timed gestation. The experimental sequence included: 1) T = 0: magnesium sulfate 4 g intravenously over 5 min followed by an infusion of magnesium sulfate at 4 g/h, or normal saline iv followed by an infusion of normal saline alone; 2) T = 135 min: 500 ml normal saline intravenously over 12 min; and 3) T = 150 min: epidural administration of 2% lidocaine. The initial bolus of magnesium sulfate slightly decreased maternal mean arterial pressure (MAP) but increased uterine artery blood flow (UBF). The increase in UBF was accompanied by an increase in fetal PaO2 at 145 min in the magnesium sulfate group but not in the control group. At 165 min (i.e., 15 min after the epidural injection of lidocaine), epidural lidocaine resulted in a median sensory level of T-10 in the magnesium sulfate group and T-11 in the control group. During epidural anesthesia, maternal MAP was lower (P = 0.001) in the magnesium sulfate group than in the control group. At 165 min, maternal MAP was 18 +/- 3% below baseline (P = 0.0001) in the magnesium sulfate group but did not differ significantly from baseline in the control group. Maternal cardiac output and UBF did not differ from baseline after epidural injection of lidocaine in either group.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: R D
authors.initials: RD
authors.lastname: Vincent
authors.forename: D H
authors.initials: DH
authors.lastname: Chestnut
authors.forename: S L
authors.initials: SL
authors.lastname: Sipes
authors.forename: C P
authors.initials: CP
authors.lastname: Weiner
authors.forename: C S
authors.initials: CS
authors.lastname: DeBruyn
authors.forename: S A
authors.initials: SA
authors.lastname: Bleuer
mesh_terms: D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D008012:Lidocaine / Q000494:pharmacology; D008278:Magnesium Sulfate / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014599:Uterus / Q000098:blood supply*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D008278:Magnesium Sulfate; D008012:Lidocaine; D010100:Oxygen