Inhibitory action of calcitonin gene-related peptide (CGRP) in the mouse colon.
The effect and mechanism of action of calcitonin gene-related peptide (CGRP) have been investigated on the mouse distal colon. CGRP caused a concentration-dependent relaxation which was not blocked by classical pharmacological antagonists. The response pattern was characterized by a relatively rapid onset and long sustained duration. The results suggest that CGRP itself may contribute to regulating the muscular tone of the mouse colon.
Cadieux
A
A
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
Pomerleau
F
F
St-Pierre
S
S
Fournier
A
A
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000502:physiology; D003106:Colon / Q000187:drug effects*; D046508:Culture Techniques; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D015740:Calcitonin Gene-Related Peptide