Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Hepatic preneoplastic nodules and hepatomas obtained in a multistep protocol of rat hepatocarcinogenesis (diethylnitrosamine, 2-acetylaminofluorene, and partial hepatectomy) showed high values of spermidine N1-acetyltransferase activity, the rate-limiting enzyme in polyamine interconversion. Such an increase was associated with the appearance of N1-acetylspermidine, an enhancement in putrescine, and a decline in spermine. Such changes suggest an activation of the interconversion pathway of high into lower polyamines in hepatic preneoplastic nodules and hepatomas.
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Consiglio Nazionale delle Ricerche Centro di Studio sulla Patologia Cellulaire, Università di Milano, Italy.
Perin
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D015073:2-Acetylaminofluorene; D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D004052:Diethylnitrosamine; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011073:Polyamines / Q000378:metabolism; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D012016:Reference Values; D013095:Spermidine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D013379:Substrate Specificity; D000099228:Diamine N-Acetyltransferase
D015073:2-Acetylaminofluorene; D000123:Acetyltransferases; D004052:Diethylnitrosamine; D011073:Polyamines; D013095:Spermidine; D000099228:Diamine N-Acetyltransferase; C017988:N(1)-acetylspermidine; C030992:polyamine N-acetyltransferase