[Pharmacologic correction of postradiation changes of pain sensitivity in rats].
With radiation injury caused by superlethal doses of 150 Gy the analgesic effect of narcotic drugs decreases and the level of drug analgesia depends on the initial status of nociceptive reactions. The role of mu-opiate mechanisms in the development of postirradiation analgesia to thermal stimuli has been determined.
Abdrakhmanov
A A
AA
Aĭtkhozhina
G K
GK
D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D002047:Buprenorphine / Q000627:therapeutic use; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000627:therapeutic use*; D005283:Fentanyl / Q000627:therapeutic use; D008297:Male; D009020:Morphine / Q000627:therapeutic use; D009270:Naloxone / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D011396:Promedol / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats
D000701:Analgesics, Opioid; D004745:Enkephalins; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009270:Naloxone; D002047:Buprenorphine; D011396:Promedol; D009020:Morphine; D005283:Fentanyl