Glutathione and related enzymes in fascioliasis before and after treatment with bithionol.
The present work is an update evaluation of the glutathione status in patients with established fascioliasis before and after treatment with bithionol. Blood glutathione (GSH), erythrocyte glutathione S-transferase (GST) and serum gamma-glutamyl transferase (GGT) activities were studied. After treatment, the variations observed in these parameters were restored to the corresponding normal control values confirming the toxic features resulting from fascioliasis and suggesting no adverse effect of bithionol on the parameters studied. We recommend the use of serum GGT, blood GSH and erythrocyte GST for the early detection of therapeutic response in fascioliasis.
Abdel-Rahman
S Z
SZ
Department of Applied Medical Chemistry, Alexandria University, Egypt.
el-Sharkawy
A M
AM
Abou-Bacha
L M
LM
Salem
A
A
D000818:Animals; D001735:Bithionol / Q000627:therapeutic use*; D002648:Child; D004912:Erythrocytes / Q000201:enzymology; D005209:Fasciola / Q000302:isolation & purification; D005211:Fascioliasis / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D005243:Feces / Q000469:parasitology; D005978:Glutathione / Q000097:blood*; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D010270:Parasite Egg Count; D005723:gamma-Glutamyltransferase / Q000097:blood*
D001735:Bithionol; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione