title: Dysplasia and DNA aneuploidy in a pelvic pouch. Report of a case.
abstract: A patient with an 18-year history of ulcerative colitis was operated on with colectomy, mucosal proctectomy, ileoanal anastomosis, and an S-type pelvic pouch due to intractable chronic continuous disease. The patient was followed by endoscopic controls and biopsy sampling from the pouch at regular intervals. A gradual development of severe atrophy in the ileal mucosa was followed by the development of low grade dysplasia. At the most recent endoscopic control, 4 years after the construction of the pouch, biopsies were sampled also for flow cytometric DNA analyses. DNA aneuploidy was detected in a biopsy from the center of the pouch, and a biopsy taken immediately adjacent showed low grade dysplasia. These findings underline the importance of endoscopic follow-up after construction of a pelvic pouch and focus attention to the potential of malignant transformation of the mucosa.
authors.affiliation: Department of Medicine, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Löfberg
authors.forename: L
authors.initials: L
authors.lastname: Liljeqvist
authors.forename: K
authors.initials: K
authors.lastname: Lindquist
authors.forename: B
authors.initials: B
authors.lastname: Veress
authors.forename: F P
authors.initials: FP
authors.lastname: Reinholt
authors.forename: B
authors.initials: B
authors.lastname: Tribukait
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000473:pathology* / Q000601:surgery; D000714:Anastomosis, Surgical; D000782:Aneuploidy; D001284:Atrophy; D001706:Biopsy; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000235:genetics / Q000473:pathology / Q000601:surgery; D004247:DNA / Q000235:genetics*; D006801:Humans; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology*; D012007:Rectum / Q000601:surgery
chemical_list: D004247:DNA