title: High resistance to experimental infection with Fasciola gigantica in Javanese thin-tailed sheep.
abstract: Innate resistance of Javanese thin-tailed sheep to Fasciola gigantica was investigated in animals infected with single doses of 150 or 500 metacercariae and killed 4, 8, 12 or 16 weeks after infection. Infected and non-infected sheep had similar values for packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin concentration, serum glutamate dehydrogenase, serum gamma glutamyl transferase and serum aspartate transferase throughout the trial, except for one animal infected with 500 metacercariae from which the highest recovery of flukes (55) was made. This animal developed pathologically altered values from 12 weeks post infection, coincident with the period of greatest hepatic haemorrhage and destruction of hepatic tissue by migrating flukes and their entry into bile ducts. However, values were altered much less than those reported in other sheep given as few as 200 metacercaria of F. gigantica. Both susceptibility to infection with F. gigantica, as indicated by percentage take of metacercariae and the severity of pathological changes were low in this study in comparison with reports involving other breeds of sheep infected with this parasite. These findings support the conclusion that Javanese thin-tailed sheep have a high innate resistance to F. gigantica.
authors.affiliation: Research Institute for Veterinary Science, Bogor, Indonesia.
authors.forename: E
authors.initials: E
authors.lastname: Wiedosari
authors.forename: D B
authors.initials: DB
authors.lastname: Copeman
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001652:Bile Ducts / Q000469:parasitology; D001947:Breeding; D004909:Erythrocyte Indices; D005209:Fasciola / Q000254:growth & development; D005211:Fascioliasis / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood; D006400:Hematocrit / Q000662:veterinary; D007113:Immunity, Innate; D016018:Least-Squares Analysis; D008099:Liver / Q000469:parasitology; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000276:immunology*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases