title: Expression of c-myc gene product in gastric carcinoma.
abstract: The expression of c-myc oncogene product was studied in 213 cases with gastric carcinoma by an immunoperoxidase method using a monoclonal antibody (MYC-1). Fifty (23.5%) of 213 tumors showed immunoreactivity to MYC-1. The distribution of c-myc-product-positive cells was observed mainly at the marginal area of the tumor. Excess reactivity to c-myc product occurred more frequently in invasive cancers than in localized cancers, and c-myc production expression in cancer tissue correlated well with peritoneal dissemination. Patients with c-myc-protein-positive tumor had significantly poorer prognosis than those with c-myc-protein-negative tumor in invasive gastric carcinomas, and the c-myc product status correlated well with the recurrence of cancer by peritoneal dissemination. These results suggest that the expression of c-myc gene product might be related to the proliferative activity of gastric carcinoma and serve as a new biologically relevant tumor marker for determining the prognosis.
authors.affiliation: 2nd Department of Surgery, School of Medicine, Kanazawa University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Ninomiya
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Kamata
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: I
authors.initials: I
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality; D005753:Gastric Mucosa / Q000737:chemistry; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis* / Q000276:immunology; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality; D015996:Survival Rate
chemical_list: D016271:Proto-Oncogene Proteins c-myc