[Inhibitory effect of secretin on gastric motility in isolated vascular perfused rat stomach].
Effect of secretin on gastric motility was studied on the preparation of isolated vascular perfused rat stomach. The results showed: (1) Secretin markedly inhibited spontaneous as well as pentagastrin stimulated antral motility. (2) Antisecretin serum completely abolished the inhibitory effect of secretin on antral motility. (3) Antisomatostatin serum and indomethacin blocked the inhibitory effect on antral motility induced by secretin. The results indicated that the inhibitory effect of secretin might be produced through direct action of secretin on secretin receptors and mediated partially by the local somatostatin and prostaglandin in gastric antrum.
Zhou
L
L
Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
Wang
L D
LD
D000818:Animals; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007106:Immune Sera / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012633:Secretin / Q000276:immunology / Q000494:pharmacology*; D013004:Somatostatin / Q000276:immunology; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D007106:Immune Sera; D012633:Secretin; D013004:Somatostatin; D007213:Indomethacin