title: Chlorpromazine and clothiapine actions at the level of the CNS and vas deferens.
abstract: CNS-level changes caused by chlorpromazine and clothiapine, a structural analogue, were studied with a battery of behavioral tests in rats, along with the ability of these two drugs to antagonize electrically and alpha-stimulator (phenylephrine-)induced contractions in the rat vas deferens. The findings indicated that clothiapine, while less effective as an alpha-receptor antagonist, was a much more active CNS-depressant than chlorpromazine.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Granada, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Pérez Raya
authors.forename: A
authors.initials: A
authors.lastname: Zarzuelo
authors.forename: J M
authors.initials: JM
authors.lastname: Duarte
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Navarro
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects*
chemical_list: D003987:Dibenzothiazepines; D002746:Chlorpromazine