Organotin compounds induce aneuploidy in human peripheral lymphocytes in vitro.
In vitro exposure of PHA-stimulated human lymphocytes to organotin compounds resulted in statistically significant increases in the frequencies of hyperdiploid cells. When taken together with our previous study demonstrating spindle inhibiting effects of the same organotin compounds by an indirect method (Jensen et al., 1989), the present study strongly indicates that organotin compounds are able to induce aneuploidy, probably by affecting spindle function.
Jensen
K G
KG
Department of Environmental Medicine, Odense University, Denmark.
Andersen
O
O
Rønne
M
M
D000328:Adult; D000782:Aneuploidy; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects; D009947:Organotin Compounds / Q000633:toxicity*; D014220:Trialkyltin Compounds / Q000633:toxicity; D014298:Trimethyltin Compounds / Q000633:toxicity
D009947:Organotin Compounds; D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; C063612:diphenyltin; C046488:trimethyltin; C039760:dimethyltin; C011559:tributyltin; C030665:triphenyltin