The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat.
The effects of intraperitoneal injection of 2-amino-5-phosphono-valeric acid (APV) on EEG-monitored penicillin-induced epileptic activity in rats were evaluated. A significant decrease in the frequency of spikes occurred with low APV dosages (10 and 20 mg/kg), while an almost complete disappearance of spike activity was observed at higher APV doses (40 and 160 mg/kg). Our data suggest that excitatory amino acids play a relevant role in penicillin-induced epileptic activity in rats.
Loeb
C
C
Department of Neurology, University of Genoa, Italy.
Patrone
A
A
Besio
G
G
Balestrino
M
M
Mainardi
P
P
D015763:2-Amino-5-phosphonovalerate / Q000627:therapeutic use*; D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010406:Penicillins / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D010406:Penicillins; D015763:2-Amino-5-phosphonovalerate