title: [Immunological status of patients with recurrent herpes simplex infections. In vitro effect of thymopoietin and splenin-derived and partially modified peptides on peripheral blood lymphocytes in comparison to a thymus extract].
abstract: Immunological studies on 20 patients with frequently recurrent Herpes simplex labialis were performed. Disorders of the cell-mediated immunity were often observed which do not only occur during the relapses. The number of T cells and their function were especially reduced. On the other hand there were no alterations of the CD4/CD8 ratio and the suppressor-activity. In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections.
authors.affiliation: Institut für Klinische Immunologie, Friedrich-Schiller-Universität, Jena.
authors.forename: H U
authors.initials: HU
authors.lastname: Simon
authors.forename: H
authors.initials: H
authors.lastname: Roth
authors.forename: K
authors.initials: K
authors.lastname: Forner
authors.forename: D
authors.initials: D
authors.lastname: Haroske
mesh_terms: D000595:Amino Acid Sequence; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens; D002908:Chronic Disease; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010446:Peptide Fragments; D013946:Thymopoietins; D013949:Thymus Extracts; D013951:Thymus Hormones; C041898:splenopentin; C032841:thymopoietin III; D016305:Thymopentin