title: Niacin-induced hepatitis: a potential side effect with low-dose time-release niacin.
abstract: Hepatitis developed in five patients who were taking low dosages (3 g/day or less) of time-release niacin. In four of the five patients, clinical symptoms of hepatitis developed after the medication had been taken for a relatively short time (2 days to 7 weeks). This manifestation of hepatotoxicity seems to differ from that previously reported in association with use of crystalline niacin, which occurred with high dosage and prolonged usage of the medication. In view of the recent increased frequency of prescribing niacin for the treatment of hyperlipidemia, physicians should be aware of the potential for hepatotoxicity with even low-dose and short-term use of time-release niacin.
authors.affiliation: Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.
authors.forename: J A
authors.initials: JA
authors.lastname: Etchason
authors.forename: T D
authors.initials: TD
authors.lastname: Miller
authors.forename: R W
authors.initials: RW
authors.lastname: Squires
authors.forename: T G
authors.initials: TG
authors.lastname: Allison
authors.forename: G T
authors.initials: GT
authors.lastname: Gau
authors.forename: J K
authors.initials: JK
authors.lastname: Marttila
authors.forename: B A
authors.initials: BA
authors.lastname: Kottke
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D003692:Delayed-Action Preparations; D009525:Niacin