title: [The role of biologically active substances in permeability changes in the blood vessels of patients with hemorrhagic fever with renal syndrome].
abstract: To judge the possible causes of the impairment of blood vascular permeability in hemorrhagic fever associated with the nephrotic syndrome (HFNS), 86 patients were examined over time for the blood content of histamine, serotonin and kallikrein. The patients were found to have hyperhistaminemia, hyperserotoninemia and activation of blood serum kallikrein, which attests to undoubted participation of these biologically active substances in the pathogenesis of HFNS.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Sidel'nikov
authors.forename: G G
authors.initials: GG
authors.lastname: Obukhova
mesh_terms: D000328:Adult; D002199:Capillary Permeability / Q000502:physiology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D003289:Convalescence; D006476:Orthohantavirus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006632:Histamine / Q000097:blood*; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin; D006632:Histamine; D002265:Carboxylic Ester Hydrolases; C019763:benzoylarginine ethyl esterase; D007610:Kallikreins