Role of somatostatin and its analogues in the pathogenesis and treatment of diabetes mellitus.
Somatostatin secreted by pancreatic D cells is a potent inhibitor of insulin, glucagon and growth hormone secretion, as well as other cells. The role of abnormal pancreatic D-cell function in diabetes mellitus is unclear. However, development of long-acting selective somatostatin analogs might prove useful in the treatment of diabetes.
Gerich
J E
JE
Department of Medicine, University of Pittsburgh School of Medicine, PA.
D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D013004:Somatostatin / Q000502:physiology* / Q000627:therapeutic use
D013004:Somatostatin