[The regression of left ventricular hypertrophy during the treatment of hypertension with different classes of beta blockers].
156 patients with hypertension II stage according to the WHO classification and left ventricular hypertrophy proved by echocardiographic examination were treated in the course of one year with various class beta-blockers. At the end of the first month of treatment the thickness of the interventricular wall, of the posterior wall and of the left ventricular muscular mass does not change. Till the end of the 6th month the thickness of all these three decreases (p less than 0.0001). The additional decrease at the end of the 12-ve month of treatment is insignificant to that at the 6th month. The mean percentage decrease is greater by treatment with beta-blockers without inner sympathomimetic activity than with beta-blockers with such activity. There is no difference in relation to the cardioselectivity of the drug. Till the end of the 12-ve month of treatment the left ventricular muscular mass becomes normal in 35.9% of the patients on the background of normalized arterial pressure. In 6.4% of the patients the left ventricular muscular mass does not change in spite of the decrease of the arterial pressure. The percentage reduction of the left ventricular muscular mass correlates with the percentage decrease of the systolic (r = 0.603), diastolic (r = 0.457) arterial pressure and the heart rate (r = 0.636).
Sirakova
V
V
Penkov
N
N
Kaponov
Kh
Kh
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012074:Remission Induction; D013997:Time Factors
D000319:Adrenergic beta-Antagonists