Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.
Roth
B D
BD
Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
Bocan
T M
TM
Blankley
C J
CJ
Chucholowski
A W
AW
Creger
P L
PL
Creswell
M W
MW
Ferguson
E
E
Newton
R S
RS
O'Brien
P
P
Picard
J A
JA
D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D015394:Molecular Structure; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013329:Structure-Activity Relationship; D013737:Testis / Q000201:enzymology
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors