The effects of polyamines and polyamine inhibitors on rat sciatic and facial nerve regeneration.
The effects of exogenous polyamines and polyamine biosynthetic pathway inhibitors on regenerating nerves were examined in adult male rats following nerve transection and surgical repair. Several studies have demonstrated the efficacy of exogenous polyamines in promoting the functional recovery of peripheral nerves following crush or freeze injuries in the rat. In order to simulate clinical peripheral nerve surgery, we studied these effects after complete nerve transection and evaluated regeneration by counting axons. There was no statistical difference in axon number with and without polyamines and in the presence of inhibitors and inhibitors with end product addition. Our study suggests that the difference in recovery seen in previous studies is not mediated by a change in axon number.
Wong
B J
BJ
Division of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange 92668.
Mattox
D E
DE
D000818:Animals; D001369:Axons / Q000502:physiology; D003714:Denervation; D000518:Eflornithine / Q000494:pharmacology; D005154:Facial Nerve / Q000502:physiology*; D008297:Male; D008340:Mandibular Nerve / Q000502:physiology; D008935:Mitoguazone / Q000494:pharmacology; D009416:Nerve Regeneration / Q000187:drug effects*; D011073:Polyamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology*
D011073:Polyamines; D008935:Mitoguazone; D000518:Eflornithine