Stimulation by xanthine oxidase of 3T3 Swiss fibroblasts and human lymphocytes.
Xanthine oxidase stimulates [3H]thymidine incorporation by 3T3 cells even in the absence of any added xanthine, but in the presence of, and synergistically with, insulin or various other growth-stimulating factors. Optimal stimulation was obtained with 2-3 mU enzyme/ml and higher concentrations were toxic. Xanthine oxidase also stimulated human peripheral blood lymphocytes in the presence of phytohemagglutinin and xanthine.
Stirpe
F
F
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
Higgins
T
T
Tazzari
P L
PL
Rozengurt
E
E
D000818:Animals; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects; D005609:Free Radicals; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000494:pharmacology*
D005609:Free Radicals; D007328:Insulin; D010835:Phytohemagglutinins; D014969:Xanthine Oxidase