Primary protection with beta-blockers in the treatment of hypertension.
The treatment of hypertension has been associated with a reduction of stroke by nearly a half but with little or no effect on the incidence of heart attack. Hypotheses to account for this discrepancy include the short duration of the trials, the differential effects on initial subsets according to age, sex and smoking status, the adverse effects of antihypertensive agents, the excessive lowering hypothesis and the common causal link hypothesis. Each of these hypotheses is examined in this paper.
Coope
J
J
Bollington Medical Centre, The Waterhouse, Macclesfield, Cheshire, UK.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D012107:Research Design; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D002784:Cholesterol