Novel biodosimetry methods applied to victims of the Goiânia accident.
Two biodosimetric methods under development at the Lawrence Livermore National Laboratory were applied to five persons accidentally exposed to a 137Cs source in Goiânia, Brazil. The methods used were somatic "null" mutations at the glycophorin A locus detected as missing proteins on the surface of blood erythrocytes and chromosome translocations in blood lymphocytes detected using fluorescence in-situ hybridization. Biodosimetric results obtained approximately 1 y after the accident using these new and largely unvalidated methods are in general agreement with results obtained immediately after the accident using dicentric chromosome aberrations. Additional follow-up of Goiânia accident victims will 1) help provide the information needed to validate these new methods for use in biodosimetry and 2) provide independent estimates of dose.
Straume
T
T
Environmental Division, Lawrence Livermore National Laboratory, University of California, Livermore 94550.
Langlois
R G
RG
Lucas
J
J
Jensen
R H
RH
Bigbee
W L
WL
Ramalho
A T
AT
Brandão-Mello
C E
CE
D000059:Accidents; D001938:Brazil; D002588:Cesium Radioisotopes; D004781:Environmental Exposure; D006801:Humans; D011829:Radiation Dosage; D011867:Radioisotope Teletherapy / Q000295:instrumentation; D011874:Radiometry / Q000379:methods
D002588:Cesium Radioisotopes