title: Injection of a cholinergic agonist in the dorsolateral pontine tegmentum of cats affects the posturokinetic responses to cortical stimulation.
abstract: Microinjection into the dorsolateral pontine tegmentum of the muscarinic agonist bethanechol, leading to activation of cholinoceptive pontine reticular formation (pRF) neurons and the related medullary inhibitory reticulospinal system, did not modify the threshold, latency and amplitude of the forelimb flexion elicited by unilateral stimulation of the corresponding motor cortex. However, the remaining limbs which displayed a diagonal pattern of postural adjustments showed a dissociation of their postural responses in 2 components: the early component of central origin greatly decreased in amplitude, while the late component attributed to reflex mechanism triggered by the unbalance brought about by the flexion movement increased. Further evidence indicated that the pRF system intervenes in the gain regulation of the early postural responses during the cortically induced limb movement.
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles, Unité de Neurosciences Integratives, CNRS, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Luccarini
authors.forename: Y
authors.initials: Y
authors.lastname: Gahery
authors.forename: O
authors.initials: O
authors.lastname: Pompeiano
mesh_terms: D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D002415:Cats / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D005552:Forelimb / Q000293:injuries / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D011149:Pons / Q000187:drug effects / Q000502:physiology*; D011187:Posture; D012016:Reference Values
chemical_list: D001626:Bethanechol Compounds; D018723:Bethanechol