title: Antigenic stability of fimbriae of Bacteroides nodosus.
abstract: Successful vaccination of sheep against footrot and attempts to eradicate the disease depend on there being a limit to the antigenic diversity of the causative bacterium, Bacteroides nodosus. Fimbrial antigenic variation was therefore investigated in vivo, both under conditions of chronic infection and under the pressure of a vaccine-induced immune response, to ascertain whether this represented an obstacle to such goals. Material was available from 5 experiments and although B. nodosus appeared to have undergone changes in its fimbrial antigens in one of these, the possibility that superinfection was responsible for the variation detected could not be ruled out because all sheep in this case were maintained at pasture. Overall, the results provided no evidence of fimbrial antigenic shift in B. nodosus in vivo and in conclusion, the survival of the organism in the sheep's foot, both in long-term natural infection and following vaccination, must therefore be related to factors other than the ability to undergo antigenic variation in order to evade the host's immune response.
authors.affiliation: Department of Animal Health, University of Sydney, Camden, New South Wales.
authors.forename: L J
authors.initials: LJ
authors.lastname: Moore
authors.forename: A T
authors.initials: AT
authors.lastname: Crowe
authors.forename: M
authors.initials: M
authors.lastname: Norman
authors.forename: C L
authors.initials: CL
authors.lastname: Kristo
authors.forename: J R
authors.initials: JR
authors.lastname: Egerton
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000032:analysis*; D001439:Bacteroides / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D015153:Blotting, Western; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D010861:Fimbriae, Bacterial / Q000276:immunology*; D005535:Foot Rot / Q000382:microbiology*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D013307:Streptomycin / Q000494:pharmacology; D014611:Vaccination / Q000662:veterinary
chemical_list: D000942:Antigens, Bacterial; D013307:Streptomycin