Synthesis, pharmacological investigations and X-ray studies on new 4,5-dihydro-1H-2,4-benzodiazepine derivatives.
The synthesis and biological activity of a series of 4,5-dihydro-1H-2,4-benzodiazepine is reported. The structure-activity relationship of these new compounds was studied based on X-ray investigations. Pharmacological investigations have shown that the compounds exert depressive action on the central nervous system and exhibit weak neuroleptic activity.
Brzezińska
E
E
Department of Technology and Chemistry of Drugs, Medical Academy, Lódź, Poland.
Glinka
R
R
Szadowska
A
A
Kiełek
M B
MB
Brzozowski
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001831:Body Temperature / Q000187:drug effects; D003460:Crystallization; D003913:Dextroamphetamine / Q000494:pharmacology; D005260:Female; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D051381:Rats; D013055:Spectrophotometry, Infrared; D013239:Stereotyped Behavior / Q000187:drug effects; D014961:X-Ray Diffraction
D014150:Antipsychotic Agents; D003913:Dextroamphetamine