title: [Significance of flumazenil in acute benzodiazepine poisoning].
abstract: Thirty-five patients over 14 years of age were evaluated, with the common feature of benzodiazepine poisoning, either as a single drug or associated with others and/or with ethanol, and who had a Glasgow score lower than 10 at admission. These patients were treated with flumazenil as a competitive antagonist drug. The results were very satisfactory. Subsequently, the possible relationship between the effect of flumazenil and the pharmacokinetic benzodiazepine profile was evaluated, and a significant relationship between the half life and the degree of resedation of the patients was found.
authors.affiliation: Servicio de Urgencias, Hospital Covadonga, Oviedo.
authors.forename: F
authors.initials: F
authors.lastname: del Busto Prado
authors.forename: A
authors.initials: A
authors.lastname: Alvarez García
authors.forename: A
authors.initials: A
authors.lastname: Ibarra Peláez
authors.forename: J
authors.initials: J
authors.lastname: Menéndez Fernándéz
authors.forename: R
authors.initials: R
authors.lastname: Barraca de Ramos
authors.forename: L
authors.initials: L
authors.lastname: Alonso Calo
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000435:Alcoholic Intoxication / Q000150:complications; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D014151:Anti-Anxiety Agents; D005442:Flumazenil