Warning: fatal reaction to the use of fibrin glue in deep hepatic wounds. Case reports.
Two cases of severe hypotension following the use of fibrin glue for hemostasis in hepatic injuries are reported. A systemic reaction to bovine thrombin via large venous lacerations is suspected. A preliminary animal study supports this hypothesis. Caution is advised in the use of fibrin glue for hemostasis in deep hepatic wounds.
Berguer
R
R
Department of Surgery, Denver General Hospital, CO 80204.
Staerkel
R L
RL
Moore
E E
EE
Moore
F A
FA
Galloway
W B
WB
Mockus
M B
MB
D000328:Adult; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006489:Hemostatic Techniques; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007267:Injections; D008099:Liver / Q000293:injuries*; D008297:Male
D015718:Fibrin Tissue Adhesive