Cellular immune response of SIV-infected rhesus macaques.
Optimal conditions for the assessment of T cell proliferation and cytolytic T lymphocyte (CTL) responses specific for primate lentivirus were established. CTL and T cell proliferative responses were demonstrated as early as two weeks post-infection. Although the majority of CTL were CD8+, MHC class I-restricted, this study demonstrated CD4+, MHC class II-restricted CTL. Experiments also demonstrated that CTL were CD16 negative. Target cell generation could be blocked with CD4 mAb specific for the SIV binding site.
McGraw
T P
TP
Department of Medical Pathology, University of California, Davis.
Vowels
B R
BR
Gershwin
M E
ME
Gardner
M B
MB
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002455:Cell Division; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D010641:Phenotype; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000914:Antibodies, Viral; D000949:Histocompatibility Antigens Class II