title: [Benzodiazepines: patterns of use, tolerance and dependence].
abstract: The authors review recent studies on benzodiazepine, the most largely used drug for insomnia and anxiety. In this paper are summarized: the development, patterns of use and abuse, mechanism of action, development of differential tolerance to its many effects, and the phenomena of withdrawal and dependence on the benzodiazepines.
authors.affiliation: Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicinada Universidade de São Paulo, Brasil.
authors.forename: M A
authors.initials: MA
authors.lastname: Bernik
authors.forename: M B
authors.initials: MB
authors.lastname: Soares
authors.forename: C N
authors.initials: CN
authors.lastname: Soares
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001569:Benzodiazepines; D004361:Drug Tolerance; D006801:Humans; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines