Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils.
The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibited pulmonary adenoma formation and the occurrence of forestomach tumors. In an additional experiment, D-limonene given p.o. 1 h prior to NNK administered i.p. again showed pronounced inhibition of pulmonary adenoma formation. This study provides additional data demonstrating that non-nutrient constituents of the diet can inhibit carcinogen-induced neoplasia when administered at a short time interval prior to carcinogen challenge.
Wattenberg
L W
LW
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Coccia
J B
JB
D000236:Adenoma / Q000517:prevention & control; D000818:Animals; D002273:Carcinogens; D002957:Citrus; D053138:Cyclohexenes; D005260:Female; D000077222:Limonene; D008175:Lung Neoplasms / Q000517:prevention & control; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D009602:Nitrosamines / Q000633:toxicity*; D010938:Plant Oils / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000517:prevention & control; D013729:Terpenes / Q000494:pharmacology*
D002273:Carcinogens; D053138:Cyclohexenes; D009602:Nitrosamines; D010938:Plant Oils; D013729:Terpenes; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; D000077222:Limonene