Differential effects of emotional and physical stress on the central and peripheral secretion of neurohypophysial hormones in male rats.
The effects of various stressful conditions on the levels of oxytocin (OT) and vasopressin (VP) in plasma and cisternal cerebrospinal fluid (CSF) of male rats were investigated. Three experimental models were used: exposure to a novel environment for 5 min, immobilization for 15 min, and ether inhalation for 10 min resulting in anaesthesia. Novelty and immobilization induced a slight but significant increase in OT levels in the CSF immediately after the stress. The effect of ether was considerably more pronounced. The concentration of VP in the CSF was elevated only by ether stress. In plasma, the level of OT was increased immediately following immobilization and ether stress but not after novelty stress, whereas VP only showed a delayed response 20 min after immobilization. These results indicate a rapid preferential release of OT in the periphery in response to physical and pharmacological stress. In addition, they provide evidence that release of OT into the CSF is triggered by physical, pharmacological as well as emotional stress, while the central release of VP is rather resistant to emotional stress. The data suggest that OT is a stress hormone in the central nervous system.
Iványi
T
T
Department of Medical Pharmacology, Rudolf Magnus Institute, Medical Faculty, University of Utrecht, The Netherlands.
Wiegant
V M
VM
de Wied
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D
D000818:Animals; D008297:Male; D010121:Oxytocin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D014667:Vasopressins / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D014667:Vasopressins; D010121:Oxytocin