L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity.
A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.
VanMiddlesworth
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Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.
Omstead
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MN
Schmatz
D
D
Bartizal
K
K
Fromtling
R
R
Bills
G
G
Nollstadt
K
K
Honeycutt
S
S
Zweerink
M
M
Garrity
G
G
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D003455:Cryptococcus neoformans / Q000187:drug effects; D004195:Disease Models, Animal; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D005936:Glucans / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008297:Male; D051379:Mice; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D047071:beta-Glucans
D000935:Antifungal Agents; D005936:Glucans; D011714:Pyrans; D047071:beta-Glucans; C065110:L 687781; C033363:beta-1,3-glucan