Repartitioning effect of a mixed beta-agonist on body composition.
Subcutaneous administration of a mixed beta-agonist to young rats induced no changes in animal growth and food conversion efficiency. However, a repartitioning effect was found with increases in lean tissue and decreases in body fat. The enhancement of muscle protein deposition was attributed to a fall in protein breakdown as muscular cathepsin A activity was lower in treated rats. A reduction of muscle reduction-oxidation state is associated to those changes in protein metabolism.
Portillo
M P
MP
Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
Martínez
J A
JA
Larralde
J
J
D000318:Adrenergic beta-Agonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002268:Carboxypeptidases / Q000378:metabolism; D043402:Cathepsin A; D002403:Cathepsins / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D007773:Lactates / Q000097:blood / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009921:Metaproterenol / Q000493:pharmacokinetics / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D011773:Pyruvates / Q000097:blood / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D007773:Lactates; D011506:Proteins; D011773:Pyruvates; D019344:Lactic Acid; D009921:Metaproterenol; D019289:Pyruvic Acid; D002268:Carboxypeptidases; D002403:Cathepsins; D043402:Cathepsin A