[Significance of neu-protein for prognosis of breast cancers].
In 147 primary breast carcinomas, over-expression of NEU-protein was detected immuno-histochemically. 20 tumours (13.6%) showed a positive reaction. Correlations with established prognostic factors, showed a significant relationship to unfavourable histological grading and negative oestrogen receptor status, as well as to the negative status of both oestrogen and progesterone receptors. However, no correlation could be demonstrated with the progesterone receptor alone. Only a trend without significance was demonstrated to the tumour size and proliferation rate-indicated by the Ki-67 antibody. No correlation existed to the status of the axillary nodes. Overexpression of NEU-protein proved to have a significant influence on the disease-free survival and overall survival in a median follow-up time of 31 months. Nevertheless, this could be shown only for tumours with metastasis in axillary nodes, but not for nodal negative tumours. A possible Longer follow-up time is necessary, to show a difference of results for the latter group.
Mitze
M
M
Universitätsfrauenklinik, Mainz.
Beck
T
T
Weikel
W
W
Rosenthal
H
H
Knapstein
P G
PG
D014408:Biomarkers, Tumor / Q000235:genetics*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D007124:Immunoenzyme Techniques; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases