title: MAL11 and MAL61 encode the inducible high-affinity maltose transporter of Saccharomyces cerevisiae.
abstract: We have investigated the transport of maltose in a genetically defined maltose-fermenting strain of Saccharomyces cerevisiae carrying the MAL1 locus. Two kinetically different systems were identified: a high-affinity transporter with a Km of 4 mM and a low-affinity transporter with a Km of 70 to 80 mM. The high-affinity maltose transporter is maltose inducible and is encoded by the MAL11 (and/or MAL61) gene of the MAL1 (and/or MAL6) locus. The low-affinity maltose transporter is expressed constitutively and is not related to MAL11 and/or MAL61. Both maltose transporters are subject to glucose-induced inactivation.
authors.affiliation: Department of Biology, Queens College, CUNY, Flushing 11367.
authors.forename: Q
authors.initials: Q
authors.lastname: Cheng
authors.forename: C A
authors.initials: CA
authors.lastname: Michels
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D005800:Genes, Fungal; D005947:Glucose / Q000494:pharmacology; D007700:Kinetics; D008320:Maltose / Q000378:metabolism; D009004:Monosaccharide Transport Proteins; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters
chemical_list: D002352:Carrier Proteins; D005656:Fungal Proteins; D009004:Monosaccharide Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters; C067575:maltose transport system, S cerevisiae; D008320:Maltose; D005947:Glucose