The proliferative response of peripheral blood mononuclear cells to streptokinase. A study of patients receiving a single intravenous infusion of purified streptokinase.
In vitro proliferative PBM responses were investigated for 26 patients with and 5 patients without acute myocardial infarction. All patients were initially treated with streptokinase (1.5 MIU infused for 1 hour). Five weeks after the disease increased responses to streptokinase, PPD and PHA were seen; but only for streptokinase had original nonresponders become responders (7 out of 14 nonresponders). The increased responsiveness to streptokinase could be detected five days after antigen infusion, and CD-2 positive cells constituted a major part of the proliferating PBM population. The responses after antigen infusion varied within a wide range both for patients with and without myocardial infarction.
Bruserud
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Medical Department B, Haukeland University Hospital, Bergen, Norway.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D018801:CD2 Antigens; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000276:immunology; D013300:Streptokinase / Q000008:administration & dosage / Q000494:pharmacology*; D014373:Tuberculin / Q000494:pharmacology
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D014373:Tuberculin; D013300:Streptokinase