[Immunocytochemical study of enterochromaffin cells in carcinoma of the large intestine].
In a series of 130 cases of adenocarcinoma of the large intestine, enterochromaffin (EC) cells were detected in 54 cases (41.5%) by immunocytochemistry with anti-chromogranin monoclonal antibody. Among the 54 cases, 30 were found positive for serotonin, 14 for somatostatin, 11 for glucagon, 5 for pancreatic polypeptide, and only one for gastrin. The cases with EC cells (++) or polypeptide positive cells exhibited higher grade of differentiation, earlier stage of tumour extension and higher survival rate than those without EC cells. A significant difference of the EC cell population pattern among different histological grades of the tumours and nonneoplastic mucosa was found. The proportion of hormone, especially polypeptide positive cells was the highest in the mucosa and lowest in the moderately poorly differentiated carcinomas. The incidence, methodology and clinicopathological significance of EC cells found in the tumours are discussed.
Chen
P H
PH
Department of Pathology, Zhejiang Medical University, Hangzhou.
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D000911:Antibodies, Monoclonal / Q000032:analysis; D002838:Chromaffin System / Q000032:analysis*; D002864:Chromogranins / Q000276:immunology; D003110:Colonic Neoplasms / Q000032:analysis / Q000473:pathology*; D004759:Enterochromaffin Cells / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D012004:Rectal Neoplasms / Q000032:analysis / Q000473:pathology*; D012701:Serotonin / Q000032:analysis; D013004:Somatostatin / Q000032:analysis
D000911:Antibodies, Monoclonal; D002864:Chromogranins; D012701:Serotonin; D013004:Somatostatin