[The species characteristics of the beta-adrenergic regulation of gastric secretion in man and dog].
In chronic experiment on dogs it has been established that the subcutaneous injection of equimolar doses of izadrine (nonselective beta-adrenergic agonist), alupent (moderately selective beta 2-adrenergic agonist) and salbutamol (predominantly beta 2-adrenergic agonist) suppresses the pentagastric secretion approximately in the same degree. The blockade of beta-adrenoreceptors by the anapriline intensifies the gastric secretion stimulated by pentagastrin. All investigated adrenoactive agents didn't effect the dogs' histamine gastric secretion. In healthy men the activation of beta 2-adrenergic receptors by alupent accompanied by the expressed intensification of basal, pentagastrin and submaximal histamine gastric secretion. The blockade of these receptors by anaprilin decreases the gastric secretion. It has been concluded that only beta 2-adrenoceptors take part in the gastric secretion regulation. Considerable specific differences in the reaction of gastric glands on the activation of beta-adrenoreceptors are revealed: in human beings it leads to the excitation, in dogs--to the suppression of secretory cells.
Fisher
A A
AA
Groĭsman
S D
SD
Shvydchenko
S I
SI
Gel'vikh
V I
VI
Polinkevich
B S
BS
Beregovaia
T V
TV
D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000818:Animals; D004285:Dogs; D005750:Gastric Juice / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D010418:Pentagastrin