title: Peripheral blood mononuclear cell subsets during Trichinella spiralis infection in pigs.
abstract: The immune response of 'Yugoslav meat breed' pigs inoculated with low doses of Trichinella spiralis muscle larvae was followed over two to nine weeks of primary infection, by analysing changes in peripheral blood mononuclear cell subsets, the development of a humoral antibody response and muscle larvae burden. During the course of the infection, infected animals showed a persistent elevation of both CD4+ and CD8+ T cell subsets from days 15 to 60 after the parasite exposure. During this time, the number of peripheral blood mononuclear cells expressing major histocompatibility complex class II antigens was also increased, while no significant differences were found in the number of circulating monocytes/macrophages and B cells over time. Humoral antibody responses to muscle larvae excretory-secretory products were evident as early as 41 days after infection, while the muscle larvae were recovered as early as 27 days after infection. The increased levels of CD4+ and CD8+ T cell subsets, as well as cells expressing major histocompatibility complex class II antigens in pigs exposed to T spiralis, may be indicative of some considerable alterations in cell subsets that are involved in the regulation of the swine immune response to this parasite.
authors.affiliation: Institute of Endocrinology, Immunology and Nutrition, INEP, Zemun, Yugoslavia.
authors.forename: D
authors.initials: D
authors.lastname: Ivanoska
authors.forename: K
authors.initials: K
authors.lastname: Cuperlović
authors.forename: J K
authors.initials: JK
authors.lastname: Lunney
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D007958:Leukocyte Count / Q000662:veterinary; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014235:Trichinellosis / Q000276:immunology / Q000662:veterinary*
chemical_list: D000909:Antibodies, Helminth; D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II