title: [Iodine-125 seed implantation in the treatment of prostatic carcinoma].
abstract: From February 1981 until August 1984 20 patients (group A) with localized prostate cancer were treated by radical pelvic lymphadenectomy and direct 125-Iodine seed implantation. From September 1984 until January 1988 51 patients (group B) underwent a modified diagnostic pelvic lymphadenectomy: four weeks later the transperineal seed implantation, guided by rectal ultrasound, followed. The follow-up period in group A is 90 months (range 72 to 114), in group B 48 months (range 30 to 70). Nine patients of group A presented with a progression of disease, four died with/of disease. Ten patients of group B developed distant metastases, three of them presented with both, distant disease and local recurrence: one patient died of disease. The Kaplan-Meier five-year survival probability is 82.3% in group A, and 96.5% in group B: the disease-free survival 62.3% and 75.2% respectively. The probability of local control is 78% in group A and 93.5% in group B. In group A there is a higher incidence of complications compared to group B, in particular concerning edemas of the legs and the genital region. The rate of impotence after seed implantation is very low (2/57 = 3.5%).
authors.affiliation: Abteilung für Strahlentherapie des Krankenhauses der Barmherzigen Schwestern, Linz, Osterreich.
authors.forename: J
authors.initials: J
authors.lastname: Hammer
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes