title: Chemically stable, lipophilic prodrugs of phosphoramide mustard as potential anticancer agents.
abstract: Benzyl phosphoramide mustard (3), 2,4-difluorobenzyl phosphoramide mustard (4), and methyl phosphoramide mustard (5) were examined as lipophilic, chemically stable prodrugs of phosphoramide mustard (2). These phosphorodiamidic esters are designed to undergo biotransformation by hepatic microsomal enzymes to produce 2. The rate of formation of alkylating species, viz., 2, from these prodrugs and their in vitro cytotoxicity toward mouse embryo Balb/c 3T3 cells were comparable to or better than that of cyclophosphamide (1). Preliminary antitumor screening against L1210 leukemia in mice, however, suggests that these prodrugs are devoid of any significant antitumor activity in vivo.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439.
authors.forename: C H
authors.initials: CH
authors.lastname: Kwon
authors.forename: K Y
authors.initials: KY
authors.lastname: Moon
authors.forename: N
authors.initials: N
authors.lastname: Baturay
authors.forename: F N
authors.initials: FN
authors.lastname: Shirota
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010752:Phosphoramide Mustards / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010752:Phosphoramide Mustards; D011355:Prodrugs