[The effects of nizatidine and misoprostol on peptic activity and gastric mucus].
The effects of Nizatidine, an H2-receptor antagonist, and Misoprostol, a PGE1 analogue, on gastric pH, pepsin, pepsinogen group I and N-acetylneuraminic acid concentration were evaluated in a group of 20 patients with duodenal ulcer. Nizatidine decreased pepsin concentration while it increased gastric pH, although not to a significant degree and left pepsinogen group I and N-acetylneuraminic acid concentration unchanged. Misoprostol did not modify gastric pH, pepsin and N-acetylneuraminic acid values but it increased pepsinogen group I levels. These data support the view that H2-receptor antagonists, especially Nizatidine, and Misoprostol do not directly affect pepsin and/or N-acetylneuraminic acid concentration.
Grassi
S A
SA
Istituto di Medicina Interna, Università di Padova.
Vianello
F
F
Germanà
B
B
Dal Santo
P
P
Faggian
D
D
Battaglia
G
G
Plebani
M
M
Di Mario
F
F
Naccarato
R
R
D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005745:Gastric Acidity Determination; D006635:Histamine H2 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016595:Misoprostol; D016567:Nizatidine; D010434:Pepsin A / Q000097:blood*; D010435:Pepsinogens / Q000097:blood*; D011899:Ranitidine / Q000494:pharmacology / Q000627:therapeutic use; D012794:Sialic Acids / Q000097:blood; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D010435:Pepsinogens; D012794:Sialic Acids; D013844:Thiazoles; D016595:Misoprostol; D011899:Ranitidine; D010434:Pepsin A; D000527:Alprostadil; D016567:Nizatidine