Two components of long-term potentiation induced by different patterns of afferent activation.
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
Grover
L M
LM
Neurobiology Department, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Teyler
T J
TJ
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D009435:Synaptic Transmission; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D002118:Calcium