Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis.
A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph + CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.
Ansell
S M
SM
Department of Medical Oncology, University of Pretoria, Republic of South Africa.
Rapoport
B L
BL
Coccia-Portugal
M A
MA
Stevens
K
K
Bester
C J
CJ
Falkson
G
G
D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D014314:Trisomy