Interactions between sialoadenectomy and capsaicin-sensitive afferent fibers on gastric acid secretion in rats.
In this study we have investigated the relative influence of capsaicin-sensitive afferents and sialoadenectomy on gastric acid secretion. Sialoadenectomized (SALX) rats showed a decrease in gastric acid secretion and an increase in gastric calcitonin gene-related peptide-like immunoreactivity (CGRP-li) as compared to sham-operated animals. Capsaicin pretreatment (50 + 100 mg kg-1 in two days) markedly decreased gastric CGRP-li in both sham and SALX-operated rats and increased acid concentration and output only in SALX animals. In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion. Gastric content of vasoactive intestinal polypeptide (VIP)-li was unaffected in SALX and capsaicin-treated rats. Capsaicin-sensitive afferents and EGF contained in the salivary glands may interact in the regulation of the gastric acid secretion.
Evangelista
S
S
Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.
Renzi
D
D
Guzzi
P
P
Maggi
C A
CA
D000704:Analysis of Variance; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology; D004064:Digestive System / Q000294:innervation* / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013361:Sublingual Gland / Q000502:physiology / Q000601:surgery; D013363:Submandibular Gland / Q000502:physiology / Q000601:surgery; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D014660:Vasoactive Intestinal Peptide; D004815:Epidermal Growth Factor; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin