Gangliosides prevent MPTP toxicity in mice--an immunocytochemical study.
The role of gangliosides in preventing neuronal degeneration was examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse parkinsonian model. Intraventricular injections of a ganglioside mixture prior to MPTP treatment reduced MPTP's toxicity on tyrosine hydroxylase-positive neurons in the substantia nigra. This raises the interesting possibility that early ganglioside administration may be beneficial in the treatment of neurodegenerative disorders.
Gupta
M
M
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, KY 40292.
Schwarz
J
J
Chen
X L
XL
Roisen
F J
FJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000037:antagonists & inhibitors; D000818:Animals; D004195:Disease Models, Animal; D005732:Gangliosides / Q000494:pharmacology*; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology; D012016:Reference Values; D013378:Substantia Nigra / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D005732:Gangliosides; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase