title: Heterogeneity of blood flow in tibial cortical bone: an experimental investigation using microspheres.
abstract: The distribution of tibial blood flow was measured by injecting approximately (600-1000) x 10(3) 15 mu microspheres, labelled with either tin-113 (113Sn) or cobalt-57 (57Co) into femoral arteries of five mature greyhounds. The diaphyseal cortex, stripped of periosteum and devoid of marrow, was sawn into 40 pieces (10 transverse sections x 4 anatomical quarters/section). Relative deposition densities of the 113Sn microspheres in 40 pieces of cortex were found. These values, together with their associated masses, proved, from a statistical point of view, that flow rate heterogeneity was substantial in the diaphysis. In particular, for the diaphyseal cortex, distribution of relative deposition densities (flow rates) in six bones was found to be positively-skewed with a relative dispersion ((SD/mean) x 100) of approximately 40%.
authors.affiliation: Department of Orthopaedic Surgery, University of Edinburgh Medical School, Scotland.
authors.forename: S M
authors.initials: SM
authors.lastname: Willans
authors.forename: I D
authors.initials: ID
authors.lastname: McCarthy
mesh_terms: D000818:Animals; D004285:Dogs; D008863:Microspheres; D012039:Regional Blood Flow; D013326:Strontium Radioisotopes; D013977:Tibia / Q000098:blood supply*
chemical_list: D013326:Strontium Radioisotopes