Angiotensin II binding receptors in retinal and optic nerve head blood vessels. An autoradiographic approach.
Angiotensin II (AII) binding sites were identified in cross-sections of the cat retinal and optic nerve vasculatures. The authors used 3H-AII and 125I-saralasin, an agonist and a high-affinity antagonist of AII receptors, respectively, to generate light microscopy autoradiograms in resin-embedded tissues. With both radioligands the presence of AII binding sites was confirmed in retinal arterioles but not in the veins or capillaries of the retina. Additionally the presence of such binding sites in the capillaries of the optic nerve head was shown. These results support the hypothesis that microvascular tone and perhaps autoregulatory responses of optic nerve capillaries might be influenced by vasoactive substances, such as AII, either leaking from the choroid or locally synthetized.
Ferrari-Dileo
G
G
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Florida 33101.
Davis
E B
EB
Anderson
D R
DR
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002196:Capillaries / Q000737:chemistry / Q000378:metabolism; D002415:Cats; D005260:Female; D008297:Male; D009898:Optic Disk / Q000098:blood supply / Q000737:chemistry* / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000032:analysis* / Q000378:metabolism; D012161:Retinal Artery / Q000737:chemistry* / Q000378:metabolism; D012169:Retinal Vein / Q000737:chemistry* / Q000378:metabolism; D012504:Saralasin / Q000378:metabolism
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D012504:Saralasin