title: Persistently low natural killer cell activity and circulating levels of plasma beta endorphin: risk factors for infectious disease.
abstract: Beta endorphin levels were quantitated in plasma samples obtained from normal subjects (n = 81, 37% males and 63% females, age range 18-45 years) as a component of a prospective study examining the relationship of illness morbidity to natural killer cell activity and psychological indices of stress. The present study was designed to test whether beta endorphin levels contributed additionally to the explanation of illness outcome variance. In the larger study, persistently low NK (LNK) activity was associated prospectively with higher illness morbidity. The findings reported here suggest that the observed LNK activity might be affected by circulating levels of plasma beta endorphin, as lower endorphin levels predicted the LNK pattern, which in turn, predicted higher illness morbidity.
authors.affiliation: University of Pittsburgh School of Medicine, PA.
authors.forename: S M
authors.initials: SM
authors.lastname: Levy
authors.forename: J
authors.initials: J
authors.lastname: Fernstrom
authors.forename: R B
authors.initials: RB
authors.lastname: Herberman
authors.forename: T
authors.initials: T
authors.lastname: Whiteside
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Ward
authors.forename: M
authors.initials: M
authors.lastname: Massoudi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D007239:Infections / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D007694:Killer Cells, Natural / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D012307:Risk Factors; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin