title: Obstetric complications, the putative familial-sporadic distinction, and tardive dyskinesia in schizophrenia.
abstract: Obstetric complications were more common in the histories of those schizophrenic outpatients without a family history of psychiatric disorder, and were associated with an earlier onset of their illness. Those patients with tardive dyskinesia were more likely to have a family history of psychiatric disorder, less likely to have experienced obstetric complications, and showed greater cognitive deficit. Obstetric complications should be considered in juxtaposition with genetic factors in evaluating the putative familial-sporadic distinction in schizophrenia. Additionally, familial/genetic factors appears to contribute to vulnerability to tardive dyskinesia.
authors.affiliation: Cluain Mhuire Family Centre, Co. Dublin, Ireland.
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
authors.forename: C
authors.initials: C
authors.lastname: Larkin
authors.forename: A
authors.initials: A
authors.lastname: Kinsella
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001925:Brain Damage, Chronic / Q000150:complications* / Q000209:etiology* / Q000523:psychology; D003692:Delayed-Action Preparations; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007744:Obstetric Labor Complications / Q000209:etiology* / Q000523:psychology; D011247:Pregnancy; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations