In vitro estimation of non-specific and specific amino acid decarboxylase activities in guinea-pigs treated with chlorpromazine.
1. In vitro studies of non-specific histidine decarboxylase activity was low or absent in control guinea-pigs and unchanged 9 or 27 hr after chlorpromazine (CPZ) injection intraperitoneally. 2. However, specific histidine decarboxylase activity was found in the control tissues and was increased 9 hr but not 27 hr after CPZ injection.
Ridzwan
B H
BH
Department of Biology, Faculty of Science and Natural Resources, University Kebangsaan Malaysia, Sabah.
Waton
N G
NG
Rozali
B O
BO
Jais
A M
AM
Maimun
A H
AH
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000378:metabolism*; D007082:Ileum / Q000187:drug effects / Q000201:enzymology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D013270:Stomach / Q000187:drug effects / Q000201:enzymology
D006632:Histamine; D006640:Histidine Decarboxylase; D002746:Chlorpromazine