title: Degradation of human cartilage by synovial fluid but not cytokines in vitro.
abstract: Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
authors.affiliation: Department of Pathology, University of Bristol, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Hollander
authors.forename: R M
authors.initials: RM
authors.lastname: Atkins
authors.forename: D M
authors.initials: DM
authors.lastname: Eastwood
authors.forename: P A
authors.initials: PA
authors.lastname: Dieppe
authors.forename: C J
authors.initials: CJ
authors.lastname: Elson
mesh_terms: D001168:Arthritis / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis; D006621:Hip Joint; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D007719:Knee Joint; D009924:Organ Culture Techniques; D010003:Osteoarthritis / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D006025:Glycosaminoglycans; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha