Synthesis and pharmacological properties of nebivolol, a new antihypertensive compound.
The synthesis of alpha,alpha' (iminobis(methylene]-bis-(3,4-dihydro-2H-1benzopyran-2-metha nol) derivatives and the stereochemistry and pharmacological profile of this new class of antihypertensive compounds are described. Finally, the selection and pharmacological profile of the preferred compound of this series, nebivolol and its enantiomers, is discussed.
Van Lommen
G
G
Janssen Research Foundation, Synthetic Department, Beerse, Belgium.
De Bruyn
M
M
Schroven
M
M
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007536:Isomerism; D000068577:Nebivolol; D011817:Rabbits; D051381:Rats
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol