Cerebrospinal fluid levels of somatostatin, corticotropin-releasing hormone and corticotropin in alcoholism.
Reduced brain and cerebrospinal fluid (CSF) levels of somatostatin, corticotropin-releasing hormone (CRH) and corticotropin (ACTH) have been reported among neuropsychiatric patients with cognitive dysfunction. Alcoholism is a disorder in which associated neuropsychiatric disorders occur. Therefore, we compared CSF levels of somatostatin, CRH and ACTH in alcoholics (n = 100) and normal controls (n = 30). There were no significant differences between the groups in concentrations of the 3 peptides. Moreover, there were no significant correlations between concentrations of the peptides in CSF and computed tomographic measures of the size of brain ventricles. There were, however, significant correlations between CSF concentrations of CRH and ACTH and between CSF concentrations of CRH and somatostatin in both the alcoholic and control groups.
Roy
A
A
Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
DeJong
J
J
Gold
P
P
Rubinow
D
D
Adinoff
B
B
Ravitz
B
B
Waxman
R
R
Linnoila
M
M
D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid*; D000328:Adult; D000437:Alcoholism / Q000134:cerebrospinal fluid* / Q000523:psychology; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D008875:Middle Aged; D010556:Personality Tests; D013004:Somatostatin / Q000134:cerebrospinal fluid*
D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone