title: Bleeding disorder (von Willebrand disease) in a quarter horse.
abstract: Bleeding diathesis in a Quarter Horse filly was caused by von Willebrand disease. Hemorrhage occurred mainly from mucosal surfaces and after trauma. Quantitative and qualitative measurements of plasma von Willebrand factor (vWF) documented a specific deficiency of vWF high molecular weight multimers, and concurrently greater than expected deficiency of vWF activity relative to vWF concentration. These findings are characteristic of type-II von Willebrand disease in human beings. Application of vWF assays used in human and small animal medicine now permits evaluation of vWF and diagnosis of von Willebrand disease in horses with bleeding disorders.
authors.affiliation: Wadsworth Center for Laboratories & Research, New York State Department of Health, Albany 12201-0509.
authors.forename: M
authors.initials: M
authors.lastname: Brooks
authors.forename: G S
authors.initials: GS
authors.lastname: Leith
authors.forename: A K
authors.initials: AK
authors.lastname: Allen
authors.forename: P R
authors.initials: PR
authors.lastname: Woods
authors.forename: R E
authors.initials: RE
authors.lastname: Benson
authors.forename: W J
authors.initials: WJ
authors.lastname: Dodds
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests; D005260:Female; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D014842:von Willebrand Diseases / Q000235:genetics / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor