title: Molecular genetic aspects of glial tumour evolution.
abstract: Cancer can be viewed as a dynamic process driven by the cellular accumulation of genetic alterations that provide selective growth advantage. Such alterations can be classified as one of two fundamental types: acquired (cancer-affective, dominant) or eliminated (cancer suppressive, recessive). This review considers genetic alterations that occur during the development of the most common type of central nervous system tumour, glioma.
authors.affiliation: Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: C D
authors.initials: CD
authors.lastname: James
authors.forename: T
authors.initials: T
authors.lastname: Mikkelsen
authors.forename: W K
authors.initials: WK
authors.lastname: Cavenee
authors.forename: V P
authors.initials: VP
authors.lastname: Collins
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D005784:Gene Amplification / Q000235:genetics; D005910:Glioma / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008967:Molecular Biology; D012150:Polymorphism, Restriction Fragment Length