[Effects of disodium cromproxate on spontaneous beating and action potentials of cultured myocardial cells of neonatal rats].
Disodium cromproxate (SCP) is an anti-allergic drug. SCP 80, 160, 320 mumol/L markedly increased spontaneous beating rate of cultured myocardial cells, especially SCP 160 mumol/L. SCP 320, 640 mumol/L increased the amplitude, maximal rate of rise and prolonged the duration of the action potentials of the cultured myocardial cells of neonatal rats. The maximal diastolic potential was not affected by SCP.
Jin
Y
Y
Department of Pharmacology, Jinzhou Medical College, China.
Wang
W X
WX
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains
D006634:Histamine H1 Antagonists; C035060:1,3-bis(2-carboxychromone-7-oxy)-2-hydroxypropane; D004205:Cromolyn Sodium