The presence of platelet-activating factor-like activity in human spermatozoa.
Evidence is provided for the existence of platelet-activating factor (PAF)-like activity in the lipid extracts of human spermatozoa. The PAF content of human spermatozoa based on [3H]-serotonin release from washed rabbit platelets was noted to be 1.45 pmol/10(8) sperm cells in highly purified motile spermatozoa. No PAF activity was associated with the seminal fluid. Platelet-activating factor content of spermatozoa may be related to its fertility potential.
Minhas
B S
BS
Department of Obstetrics and Gynecology, East Tennessee State University, James H. Quillen College of Medicine, Johnson City 37614.
Kumar
R
R
Ricker
D D
DD
Robertson
J L
JL
Dodson
M G
MG
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008055:Lipids / Q000302:isolation & purification; D008297:Male; D010743:Phospholipids / Q000302:isolation & purification*; D010972:Platelet Activating Factor / Q000032:analysis* / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000097:blood; D013081:Sperm Motility; D013094:Spermatozoa / Q000737:chemistry* / Q000502:physiology
D008055:Lipids; D010743:Phospholipids; D010972:Platelet Activating Factor; D012701:Serotonin