title: [Autosomal dominant polycystic kidney and genetic markers of chromosome 16].
abstract: The mutation for autosomal dominant polycystic kidney disease (APKD) has been mapped by linkage analysis on the distal part of the short arm of chromosome 16. We present in this study the results of linkage analysis using the two most tightly linked DNA markers (3'HVR and 24-1) in 183 members of 14 families of a same ethnic origin. We have constructed haplotypes using these two polymorphic probes, and compared the frequency of these on the normal and the affected chromosome. No evidence of linkage heterogeneity was found in our population.
authors.affiliation: Laboratoire de Biologie Moléculaire, Centre Départemental de Transfusion Sanguine, Centre Hospitalier Universitaire, Brest.
authors.forename: C
authors.initials: C
authors.lastname: Ferec
authors.forename: B
authors.initials: B
authors.lastname: Bourbigot
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: B
authors.initials: B
authors.lastname: Whebe
authors.forename: H
authors.initials: H
authors.lastname: Treguer
authors.forename: J P
authors.initials: JP
authors.lastname: Hervé
authors.forename: J P
authors.initials: JP
authors.lastname: Saleun
authors.forename: J
authors.initials: J
authors.lastname: Cledes
mesh_terms: D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D010375:Pedigree; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers