title: [Metastatic C-cell carcinoma with bone marrow carcinosis in type IIa multiple endocrine neoplasia (MEN). Diagnostic and therapeutic problems].
abstract: The course of the disease in a patient with multiple endocrine neoplasia type IIa over a period of seven years is described. In spite of multiple diagnostic procedures, only a bone marrow biopsy was able to prove metastatic disease. All therapeutic measures, such as combination chemotherapy, sandostatin, bromocriptine, and 131Iodinemethylendiphosphonate-therapy were not effective in reducing tumor load or symptoms.
authors.affiliation: Onkologisches Zentrum, Klinikum Mannheim der Universität Heidelberg.
authors.forename: M E
authors.initials: ME
authors.lastname: Heim
authors.forename: J
authors.initials: J
authors.lastname: Hastka
authors.forename: W
authors.initials: W
authors.lastname: Queisser
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000628:therapy*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000628:therapy*
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002116:Calcitonin