title: First analysis of the F508 deletion in cystic fibrosis patients from the GDR.
abstract: Cystic fibrosis (CF) patients (n = 157) from the GDR were analysed for the occurrence of the recently discovered 3bp deletion causing CF. About 50% of all investigated patients were homozygotes and about 30% heterozygotes for this deletion. Of the analysed CF chromosomes from these patients, 62% carry the deletion, which is in strong linkage disequilibrium with the KM19 restriction fragment length polymorphism allele 2 and the 1/2 XV2c/KM19 haplotype.
authors.affiliation: Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der DDR, Berlin.
authors.forename: K
authors.initials: K
authors.lastname: Grade
authors.forename: K
authors.initials: K
authors.lastname: Will
authors.forename: R
authors.initials: R
authors.lastname: Szibor
authors.forename: J
authors.initials: J
authors.lastname: Gedschold
authors.forename: R
authors.initials: R
authors.lastname: Brückner
authors.forename: I
authors.initials: I
authors.lastname: Bauer
authors.forename: K
authors.initials: K
authors.lastname: Giermann
authors.forename: H
authors.initials: H
authors.lastname: Gorki
authors.forename: J
authors.initials: J
authors.lastname: Hein
authors.forename: U
authors.initials: U
authors.lastname: Brell
mesh_terms: D002872:Chromosome Deletion; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D005860:Germany, West; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length