title: [The central nervous system and inflammation: the role of opioid peptides].
abstract: Inhibition of human granulocyte aggregation was observed in the presence of morphine in a naloxone stereoselective way, while the opioid peptides were ineffective. In comparative studies Ca(+)+ (A23187) and dynorphin 1-9, per se, induced stimulation of arachidonic acid metabolites from granulocytes. In this regard dynorphin 1-9 may function as a mediator between the central nervous system and the inflammation.
authors.affiliation: Dipartimento di Medicina Interna, Università di Pavia.
authors.forename: A
authors.initials: A
authors.lastname: Mazzone
authors.forename: G
authors.initials: G
authors.lastname: Ricevuti
authors.forename: A
authors.initials: A
authors.lastname: Fioravanti
authors.forename: D
authors.initials: D
authors.lastname: Pasotti
authors.forename: A R
authors.initials: AR
authors.lastname: Vitto
authors.forename: L
authors.initials: L
authors.lastname: Mirto
authors.forename: C
authors.initials: C
authors.lastname: Vignali
authors.forename: F
authors.initials: F
authors.lastname: Avato
authors.forename: A
authors.initials: A
authors.lastname: Notario
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology*; D004399:Dynorphins / Q000494:pharmacology; D004723:Endorphins / Q000502:physiology*; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D007975:Leukotriene B4 / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D013931:Thromboxanes / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D004723:Endorphins; D010446:Peptide Fragments; D013931:Thromboxanes; D007975:Leukotriene B4; D009270:Naloxone; D004399:Dynorphins; D009020:Morphine; C040238:dynorphin A (1-9)