New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia.
The karyotype 47,XX, + 8,t(12;22)(p13;q12) was found at diagnosis in two patients with acute nonlymphocytic leukemia (ANLL). The bone marrow morphology of both patients corresponded to the M4 subtype of the French-American-British (FAB) classification. The translocation t(12;22) has not previously been reported as the sole structural aberration in ANLL.
Callen
D F
DF
Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
Hull
Y J
YJ
Toogood
I R
IR
Fioretos
T
T
Heim
S
S
Mandahl
N
N
Mitelman
F
F
D000328:Adult; D002648:Child; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014314:Trisomy