Intensive chemotherapy and autologous peripheral blood stem cell transplantation in a patient with persistent marrow involvement with Hodgkin's disease.
A patient with refractory Hodgkin's disease whose persistent, dense marrow infiltration precluded autologous marrow harvest underwent peripheral blood stem cell harvest followed by intensive chemotherapy and re-infusion of the peripheral blood stem cells. Complete remission was followed by relapse 6 months later and death 13 months post-transplant. However, at no time post-transplant was evidence of marrow recurrence demonstrated. This case indicates that remission can be achieved using peripheral blood stem cell transplants despite persistent marrow involvement with Hodgkin's disease.
Phillips
G L
GL
Leukemia and Bone Marrow Transplantation Program of British Columbia, Vancouver General Hospital, Canada.
Reece
D E
DE
Lerner
K G
KG
Connors
J M
JM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001803:Blood Transfusion / Q000379:methods*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods*; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007937:Leukapheresis; D008297:Male; D014182:Transplantation, Autologous