Effect of phenytoin on plasma clozapine concentrations in two patients.
Little is known about interactions of other drugs with the recently marketed antipsychotic clozapine. Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed.
Miller
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Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
D000328:Adult; D003024:Clozapine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology
D010672:Phenytoin; D003024:Clozapine