Cerebral venous thrombosis with plasminogen deficiency.
We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We also discuss the evidence linking plasminogen deficiency with a thrombophilic state. The diagnosis of cerebral venous thrombosis in this case was readily established by nuclear magnetic resonance imaging, a technique that is ideally suited for the evaluation and follow-up of patients with this condition.
Schutta
H S
HS
Department of Neurology, University of Wisconsin School of Medicine, Madison.
Williams
E C
EC
Baranski
B G
BG
Sutula
T P
TP
D000328:Adult; D001921:Brain / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D010958:Plasminogen / Q000172:deficiency*; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D010958:Plasminogen