Structural comparison of assemblies from brain microtubule proteins of different vertebrates.
Formerly, we reported for microtubule protein (MTP), i.e. tubulin plus microtubule-associated proteins (MAPs), from porcine brain that the protofilament number of microtubules and the percentage of aberrant assemblies depend on taxol and MAP activity (Böhm et al., BBA 800, 119, 1984). Now, it is demonstrated that these effects can be also observed when MTPs from other higher vertebrate brains (Guinea pig, mouse chicken) were used. Comparing the structural features of assemblies formed from these kinds of MTP with each other no significant differences were found, excepted chicken MTP which produces more aberrant assemblies in the presence of taxol.
Steinmetzer
P
P
Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of the GDR, Jena.
Böhm
K J
KJ
Vater
W
W
Unger
E
E
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D002645:Chickens; D006168:Guinea Pigs; D051379:Mice; D008854:Microscopy, Electron; D008868:Microtubule Proteins / Q000302:isolation & purification / Q000648:ultrastructure*; D017239:Paclitaxel; D013552:Swine; D014714:Vertebrates
D000470:Alkaloids; D008868:Microtubule Proteins; D017239:Paclitaxel