[Efficacy of combination of Ea-0643 (bunazosin hydrochloride) and bethanechol chloride in patients with neurogenic bladder].
Bethanechol chloride, a cholinergic agent and bunazosin hydrochloride, an alpha adrenergic blocking agent were administered orally to 28 patients with neurogenic bladder due to peripheral nerve disorders. To compare the effect of the two drugs, one of the drugs was initially administered orally for 2 weeks, and then both of them were administered for the next 2 weeks. Since there were some significant differences in the patient background between the two groups, it was difficult to compare the two drugs. However combined use of these drugs resulted in both objective and subjective good responses in those patients.
Araki
T
T
Department of Urology, Mie University School of Medicine.
Nakano
S
S
Sugimura
Y
Y
Tochigi
H
H
Kawamura
J
J
Kato
T
T
Tajima
K
K
Chigusa
I
I
Saito
K
K
Morisita
H
H
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage*; D000368:Aged; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010277:Parasympathomimetics / Q000008:administration & dosage*; D011799:Quinazolines / Q000008:administration & dosage*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*
D000317:Adrenergic alpha-Antagonists; D001626:Bethanechol Compounds; D010277:Parasympathomimetics; D011799:Quinazolines; D018723:Bethanechol; C018176:bunazosin