title: Body composition and energy expenditure in adolescents with cerebral palsy or myelodysplasia.
abstract: We measured body composition, resting metabolic rate (RMR), and total energy expenditure (TEE) in a group of adolescents with cerebral palsy (CP) and myelodysplasia (M) aged 13- to 20-y-old using indirect calorimetry and the doubly labeled water method. Fat-free mass (FFM), RMR, and TEE were significantly lower in both the CP and M groups than comparable measurements in a control group of normal adolescent males and females. The ratio of TEE to RMR did not differ between controls and ambulatory M and CP subjects. However, TEE/RMR was significantly lower in the nonambulatory M and CP subjects than in controls (p less than 0.01). Our data indicate that energy requirements are reduced in both populations because both FFM and activity are decreased. Although energy requirements were decreased in both groups, the relationships between FFM and body weight differed. FFM and body weight were significantly correlated with RMR only in the M group. These data suggest that the type of paralysis in a handicapped population may affect resting energy expenditure.
authors.affiliation: Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: L G
authors.initials: LG
authors.lastname: Bandini
authors.forename: D A
authors.initials: DA
authors.lastname: Schoeller
authors.forename: N K
authors.initials: NK
authors.lastname: Fukagawa
authors.forename: L J
authors.initials: LJ
authors.lastname: Wykes
authors.forename: W H
authors.initials: WH
authors.lastname: Dietz
mesh_terms: D000293:Adolescent; D000328:Adult; D001823:Body Composition; D001824:Body Constitution; D001834:Body Water / Q000378:metabolism; D002547:Cerebral Palsy / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D009436:Neural Tube Defects / Q000378:metabolism* / Q000473:pathology