Genomic sequence and organization of two members of a human lectin gene family.
We have isolated and sequenced the genomic DNA encoding a human dimeric soluble lactose-binding lectin. The gene has four exons, and its upstream region contains sequences that suggest control by glucocorticoids, heat (environmental) shock, metals, and other factors. We have also isolated and sequenced three exons of the gene encoding another human putative lectin, the existence of which was first indicated by isolation of its cDNA. Comparisons suggest a general pattern of genomic organization of members of this lectin gene family.
Gitt
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Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco 94143-0984.
Barondes
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SH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015342:DNA Probes; D015698:Genomic Library; D006801:Humans; D037102:Lectins / Q000235:genetics*; D007962:Leukocytes / Q000276:immunology; D008969:Molecular Sequence Data; D005810:Multigene Family; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D015342:DNA Probes; D037102:Lectins; D015345:Oligonucleotide Probes; D004247:DNA