Islet cell and other organ-specific autoantibodies in Chinese children with insulin-dependent diabetes mellitus.
Islet cell autoantibodies (ICA) and other organ-specific autoantibodies were detected in 27 Chinese children with insulin-dependent diabetes mellitus (IDDM). The frequency of ICA within the first year of diagnosis was 67%, and it declined as the duration of the disease increased. The frequencies of thyroid microsomal autoantibodies and gastric parietal cell autoantibodies were 26% and 11%, respectively. None of the patients had adrenal autoantibodies. These results are comparable to those reported in Caucasian patients. Similar frequencies of islet cell autoantibodies and other organ-specific autoantibodies in children with IDDM between Chinese and Caucasians suggest that the autoimmune process may play an important role in the pathogenesis of Chinese children with IDDM.
Tsai
W Y
WY
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
Riley
W J
WJ
Lee
J S
JS
Tsai
W S
WS
D000293:Adolescent; D000311:Adrenal Glands / Q000276:immunology; D001323:Autoantibodies / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008861:Microsomes / Q000276:immunology; D010295:Parietal Cells, Gastric / Q000276:immunology; D013624:Taiwan; D013961:Thyroid Gland / Q000276:immunology
D001323:Autoantibodies