title: Effects of in vitro electrical stimulation on enhancement and suppression of malignant lymphoma cell proliferation.
abstract: The suppression and enhancement of proliferation of mouse EL4 lymphoma cells varied significantly when the cells were electrically stimulated within a narrow range of low-level direct current. With the use of platinum electrodes, the suppression characteristics were observed over a narrow range, or window, of direct currents centered at approximately 17 microA. Enhancement characteristics were observed over a broad range of low-level direct currents (approximately 0.1 to 10 microA). These results indicate that the proliferation of certain eukaryotic cells may be directly controlled by stimulation with low-level direct current.
authors.affiliation: Department of Biological Sciences, Mankato State University, MN 56002-8400.
authors.forename: M
authors.initials: M
authors.lastname: Lyte
authors.forename: J E
authors.initials: JE
authors.lastname: Gannon
authors.forename: G D
authors.initials: GD
authors.lastname: O'Clock
mesh_terms: D000818:Animals; D002455:Cell Division; D004558:Electric Stimulation; D004566:Electrodes; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D014407:Tumor Cells, Cultured