HLA-DR RFLP distributions in two groups of aboriginal Australians.
HLA-DR and -DQ typing by restriction fragment length polymorphism (RFLP) in Aboriginal Australians from the Kimberleys and from Coen shows a restricted number of HLA-DR types in these populations. The polymorphism is essentially limited to DR2, DR4, DRw14 and DRw8. The most common DR.DQ RFLP haplotype in Aborigines shows a novel arrangement of DR and DQ alleles that has important implications for histocompatibility matching if the RFLP patterns reflect functional variation in HLA class II molecules.
Davies
R
R
John Curtin School of Medical Research, ACT.
Pace
R
R
Jazwinska
E C
EC
Serjeantson
S W
SW
D001315:Australia; D005828:Genetics, Population; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D000095283:Australian Aboriginal and Torres Strait Islander Peoples
D006684:HLA-DR Antigens