title: The effect of cigarette smoke on the plasma piroxicam concentrations in rats.
abstract: The plasma concentration of unchanged piroxicam has been determined at 15, 30, 60 and 90 min after 10 mg kg-1 oral administration of the drug to rats exposed to cigarette smoke or pretreated with phenobarbitone, 3,4-benzpyrene or ethanol. Plasma piroxicam concentrations decreased in rats pretreated with phenobarbitone, 3,4-benzpyrene and ethanol and in rats 24 h after exposure to cigarette smoke.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Lermioğlu
authors.forename: T
authors.initials: T
authors.lastname: Berkan
authors.forename: M
authors.initials: M
authors.lastname: Yasa
authors.forename: Z
authors.initials: Z
authors.lastname: Kerry
authors.forename: C
authors.initials: C
authors.lastname: Yalçinkaya
authors.forename: A
authors.initials: A
authors.lastname: Ozer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D010894:Piroxicam / Q000097:blood*; D051381:Rats; D014028:Tobacco Smoke Pollution
chemical_list: D001580:Benzopyrenes; D014028:Tobacco Smoke Pollution; D010894:Piroxicam; D000431:Ethanol; D010634:Phenobarbital