T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis.
Encephalitogenic T cells specific for myelin basic protein share common V beta 8 peptide sequences in their T cell receptor (TCR) that can induce autoregulatory T cells and antibodies that prevent clinical signs of experimental autoimmune encephalomyelitis (EAE). It is not known, however, if TCR peptides can treat established disease. To test its therapeutic value, TCR-V beta 8-39-59 peptide was injected into rats with clinical signs of EAE. This treatment reduced disease severity and speeded recovery, apparently by boosting anti-V beta 8 T cells and antibodies raised naturally in response to encephalitogenic V beta 8+ T cells. These results demonstrate that synthetic TCR peptides can be used therapeutically, and implicate the TCR-V beta 8-39-59 sequence as a natural idiotope involved in EAE recovery. Similarly, human TCR peptides may be effective in enhancing natural regulation of autoreactive T cells that share common V genes.
Offner
H
H
Neuroimmunology Research, Veterans Administration Medical Center, Portland, OR.
Hashim
G A
GA
Vandenbark
A A
AA
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D004679:Encephalomyelitis / Q000276:immunology / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D006968:Hypersensitivity, Delayed; D007106:Immune Sera / Q000276:immunology; D007111:Immunity, Cellular; D007167:Immunotherapy; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D007106:Immune Sera; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; C066890:T cell receptor-V(beta)8-39-59 peptide