title: The role of infection in the morbidity and mortality of patients with head and neck cancer undergoing multimodality therapy.
abstract: Cancer of the head and neck is a common cancer worldwide. The majority of patients present with locally advanced disease. Recently a great deal of improvement has been made in multimodality therapy of this disease, warranting more careful consideration of factors affecting quality of life, disease course, and treatment. Infection is clearly a factor. Analysis of 662 hospital admissions of 169 head and neck cancer patients was performed. A definite infection was documented in 86 febrile episodes, pneumonia contributed to 40%, bacteremia to 13%, skin and soft tissue infection to 12%, and tracheobronchitis to 10%. Among the evaluated risk factors, foreign bodies, specifically intravenous (IV) cannulae and gastrostomy tubes, race, performance status, alcohol intake, and nutritional status were statistically significant variables that predicted for or were associated with infection. Infection contributed to 44% of the deaths.
authors.affiliation: Division of Hematology and Oncology, Wayne State University, Harper-Grace Hospitals, Detroit, MI 48201.
authors.forename: M
authors.initials: M
authors.lastname: Hussain
authors.forename: J A
authors.initials: JA
authors.lastname: Kish
authors.forename: L
authors.initials: L
authors.lastname: Crane
authors.forename: A
authors.initials: A
authors.lastname: Uwayda
authors.forename: G
authors.initials: G
authors.lastname: Cummings
authors.forename: J F
authors.initials: JF
authors.lastname: Ensley
authors.forename: E
authors.initials: E
authors.lastname: Tapazoglou
authors.forename: M
authors.initials: M
authors.lastname: al-Sarraf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002406:Catheterization, Peripheral / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005334:Fever / Q000209:etiology; D005774:Gastrostomy / Q000009:adverse effects; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007239:Infections / Q000209:etiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D012307:Risk Factors; D015996:Survival Rate