Effect of aldosterone antagonist on the DC potential in the endolymphatic sac.
The effect of aldosterone and canrenoate, known as an aldosterone antagonist, on the DC potential in the endolymphatic sac (ESP) was examined in the guinea pig. Intravenous administration of aldosterone (1 mg/kg) induced no change in the ESP for 60 minutes after the injection. However, canrenoate, an aldosterone antagonist, produced a dose-dependent decrease in the ESP. Pretreatment with aldosterone attenuated the decrease in the ESP by canrenoate. The results suggest the possibility that aldosterone may play a role in the endolymph absorption of the endolymphatic sac.
Mori
N
N
Department of Otolaryngology, Kagawa Medical School, Japan.
Yura
K
K
Uozumi
N
N
Sakai
S
S
D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology*; D004712:Endolymphatic Sac / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D008564:Membrane Potentials / Q000187:drug effects
D000450:Aldosterone; D002191:Canrenoic Acid