The nucleotide sequence of the gene encoding the attachment protein H of canine distemper virus.
The sequence of the H gene and flanking sequences in the F and L genes of canine distemper virus (CDV) have been determined. The H gene of CDV (1946 nucleotides) contains one large open reading frame starting at position 21 and terminating at position 1835, encoding a protein of 604 amino acid residues. This protein contains three potential glycosylation sites in the extracellular domain and, like all other paramyxoviruses, a N-terminal membrane-spanning hydrophobic anchor domain. The deduced H protein sequence shows an identity of 36% with rinderpest virus (RPV) and measles virus (MV). The identities at the nucleotide level are higher (RPV 52% and MV 53%). The amino acid sequence shows conservation of all the structural determinants with the H proteins of MV and RPV. The data also show that CDV is evolutionarily equidistant to RPV and MV with respect to the H gene.
Curran
M D
MD
Division of Genetic Engineering, School of Biology and Biochemistry, Queen's University of Belfast, U.K.
Clarke
D K
DK
Rima
B K
BK
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004217:Distemper Virus, Canine / Q000235:genetics*; D004285:Dogs; D005814:Genes, Viral; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins