Characteristics of 86Rb+ transport in human erythrocytes infected with Plasmodium falciparum.
Human red cells infected in vitro with Plasmodium falciparum showed a significant increase in the rate of both ouabain-sensitive and ouabain-insensitive 86Rb+ influx. The increase in ouabain-insensitive 86Rb+ influx was due, in part, to increased transport via a bumetanide-sensitive system and, in part to transport via a pathway that was absent (or at least inactive) in uninfected cells. The parasite-induced pathway was inhibited by piperine and had a dose response very similar to that of the Gardos channel of uninfected cells but was less sensitive than the Gardos channel to inhibition by quinine.
Kirk
K
K
University Laboratory of Physiology, Oxford, U.K.
Ashworth
K J
KJ
Elford
B C
BC
Pinches
R A
RA
Ellory
J C
JC
D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D001692:Biological Transport; D002034:Bumetanide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011188:Potassium / Q000378:metabolism; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology; D012414:Rubidium Radioisotopes
D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D012414:Rubidium Radioisotopes; D002034:Bumetanide; D010042:Ouabain; D011803:Quinine; D011188:Potassium; C008922:piperine