[Effect of naloxone on basal, by somatostatin inhibited stomach secretion in patients with chronic duodenal ulcer].
In 13 men with chronic duodenal ulcer disease effects of somatostatin and naloxone on basic gastric secretion were determined. Following intravenous somatostatin infusion a significant increase in basic gastric secretion was observed. Somatostatin also induced a significant increase in sodium concentration and a decrease in chloride concentration in the gastric juice. Total electrolyte and mucoprotein secretions changed proportionally to alterations in the gastric juice volume. Somatostatin-induced gastric secretion was unaffected by a single intravenous naloxone administration. In patients with chronic duodenal ulcer disease somatostatin and naloxone affect gastric secretion independently of each other.
Lukin
M
M
I. Medizinische Klinik des Instituts für Innere Medizin Medizinischen Akademie Lódź.
Markiewicz
K
K
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*
D001786:Blood Glucose; D009270:Naloxone; D013004:Somatostatin