Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent.
Intact male and female spontaneously hypertensive rats showed a progressive increase in blood pressure with growth; male attained systolic blood pressure levels of 244 +/- 6 mmHg, and females 205 +/- 3 mmHg at age 22 weeks. Orchidectomy at age 4 weeks significantly attenuated the systolic blood pressure elevation in the male (195 +/- 4 mmHg at age 22 weeks), but ovariectomy at age 4 weeks had no effect on the development of hypertension in the female. The pattern of development of hypertension in orchidectomized males was the same as that in intact and ovariectomized females. Administration of testosterone propionate to gonadectomized rats of both sexes conferred a male pattern of blood pressure development. These results indicate that the sexually dimorphic pattern of hypertension in the spontaneously hypertensive rat is androgen dependent, rather than estrogen dependent. Plasma norepinephrine levels did not differ between the sexes, nor were they altered by gonadectomy or testosterone replacement, suggesting that the higher blood pressures in the intact male and androgen treated male and female SHR are not dependent on increased sympathetic outflow in the established phase of hypertension. Stores of norepinephrine in the posterior hypothalamic region were significantly greater in intact male rats and testosterone treated rats of both sexes than in intact or ovariectomized females, and were higher in the pons of intact female rats than in all other groups. These alterations in central catecholamine stores were not correlated with blood pressure. Further study is needed to assess the functional significance of these androgen mediated alterations in posterior hypothalamic neurons as a determinant of the androgen mediated sexual dimorphism of blood pressure in the spontaneously hypertensive rat.
Chen
Y F
YF
Department of Medicine University of Alabama, Birmingham 35294.
Meng
Q C
QC
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D004837:Epinephrine / Q000097:blood; D005260:Female; D008297:Male; D009206:Myocardium; D009638:Norepinephrine / Q000097:blood; D009919:Orchiectomy; D009929:Organ Size; D010052:Ovariectomy; D051381:Rats; D011918:Rats, Inbred SHR; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D009638:Norepinephrine; D004837:Epinephrine