title: Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.
abstract: Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
authors.affiliation: Biochemistry Department, University of Oxford, UK.
authors.forename: D
authors.initials: D
authors.lastname: Broek
authors.forename: R
authors.initials: R
authors.lastname: Bartlett
authors.forename: K
authors.initials: K
authors.lastname: Crawford
authors.forename: P
authors.initials: P
authors.lastname: Nurse
mesh_terms: D016203:CDC2 Protein Kinase / Q000502:physiology*; D002453:Cell Cycle; D004261:DNA Replication; D005656:Fungal Proteins / Q000378:metabolism; D008938:Mitosis; D009154:Mutation; D009584:Nitrogen / Q000378:metabolism; D016196:S Phase; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics
chemical_list: D005656:Fungal Proteins; D016203:CDC2 Protein Kinase; D009584:Nitrogen