Activation of a novel medullary pathway elicits a vagal, cholinergic bronchoconstriction in guinea-pigs.
Electrical stimulation of structures within the rostral region of the dorsal medulla of the guinea-pig activates a vagal cholinergic bronchoconstriction pathway and simultaneously activates a sympathetic inhibitory input. Removal of the latter by spinal section potentiated CNS-induced bronchospasm.
Hey
J A
JA
Department of Allergy and Inflammation, Schering-Plough Research, New Jersey 07003.
del Prado
M
M
Chapman
R W
RW
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005730:Ganglionic Blockers / Q000494:pharmacology; D006168:Guinea Pigs; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D009241:Ipratropium / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology*
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D018738:Hexamethonium; D008012:Lidocaine; D009241:Ipratropium; D000109:Acetylcholine