Local enkephalins tonically modulate dopamine release in the striatum: a microdialysis study.
Kelatorphan, an inhibitor of the enkephalin-degrading enzymes, infused by microdialysis (10(-6) M) in the striatum of anaesthetized rats, significantly increased dopamine (DA) output but left dihydroxyphenylacetic acid and homovanillic acid extracellular levels unchanged. The local application of naltrexone (10(-6) M) prevented the effect of kelatorphan on DA release. These data indicate that local enkephalins tonically modulate DA release in rat striatum.
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U.A. 1170 du C.N.R.S., U.F.R. de Médecine et de Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Michael-Titus
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Costentin
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D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000378:metabolism; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D018826:CD13 Antigens; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D003956:Dialysis; D004151:Dipeptides / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004745:Enkephalins / Q000502:physiology; D008297:Male; D008969:Molecular Sequence Data; D009271:Naltrexone / Q000494:pharmacology; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity
D000700:Analgesics; D004151:Dipeptides; D004745:Enkephalins; C042591:kelatorphan; D009271:Naltrexone; D000626:Aminopeptidases; D018826:CD13 Antigens; D015260:Neprilysin; D004298:Dopamine