Genetic and physical mapping and population studies of a fibronectin receptor beta-subunit-like sequence on human chromosome 19.
A cDNA clone of the beta subunit of human fibronectin receptor (FNRB) detects two different polymorphic loci: (a) a codominant system previously mapped to the pericentromeric region of chromosome 10, the site of the functional FNRB gene; and (b) a dominant system not linked to the first one or to any chromosome 10 marker tested. This second polymorphism is characterized by the presence or absence of a band (or a set of bands). We have used linkage analysis and biotin-labeled in situ hybridization to map this dominant polymorphism to the short arm of chromosome 19; we hypothesize that it may be due to the insertion of part of the cDNA from the chromosome 10 gene into chromosome 19. This "insertion" is polymorphic in all populations studied.
Giuffra
L A
LA
Department of Human Genetics, Yale School of Medicine, New Haven, Connecticut 06510.
Lichter
P
P
Wu
J S
JS
Kennedy
J L
JL
Pakstis
A J
AJ
Rogers
J
J
Kidd
J R
JR
Harley
H
H
Jenkins
T
T
Ward
D C
DC
D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005006:Ethnicity; D005787:Gene Frequency; D006801:Humans; D008126:Lod Score; D012150:Polymorphism, Restriction Fragment Length; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000235:genetics*
D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic