[Effects of pentacin on subcellular distribution of Pu-239 nitrate in the lungs of rats].
The method of differential centrifugation has shown that 26% of 239Pu-nitrate injected intratracheally, is detected in cells in 3 h (24.4% of Pu is bound with subcellular organellae). In 24 h the nuclear fraction acquires a paramount importance in Pu binding. In the hyaloplasm 239Pu is distributed equally between low molecular (32.9-42.9%) and high molecular (54.1-55.2%) proteins. Pentacine decreases the level of Pu in the lungs, in the sum of subcellular fractions and in the sum of organellae, but produces no noticeable action on the level of the radionuclide in hyaloplasmic proteins though promotes certain redistribution of the radionuclide between low- and high molecular proteins.
Kabirova
N R
NR
Sokhranich
A L
AL
D000818:Animals; D002951:Citrates / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism*; D008297:Male; D015388:Organelles / Q000378:metabolism; D004369:Pentetic Acid / Q000494:pharmacology*; D011005:Plutonium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism
D002951:Citrates; D011005:Plutonium; D004369:Pentetic Acid