Spontaneous degenerative polyarthritis in male New Zealand black/KN mice.
Histopathologic studies and radiographic analysis revealed that male New Zealand black/KN (NZB/KN) mice develop degenerative polyarthritis in the joints of the forepaw and hindpaw beginning at age 2 months. Deposits of autoantibodies were observed on proliferating collagen fibers, nuclei of chondrocytes, and epidermal cells. Increases in the frequency of positivity for rheumatoid factor and anti-type II collagen antibodies and in the level of serum oxidation activity were noted in these mice. The joint disease in male NZB/KN mice was transferable to female NZB/KN mice and male BALB/c mice by intraperitoneal injection of spleen cells from the male NZB/KN mice. This animal model of arthritis will be extremely useful for analyzing not only the pathogenesis of rheumatoid arthritis, but also new strategies for its treatment, since NZB/KN mice, unlike MRL/lpr mice, do not develop severe lupus nephritis or lymph-adenopathy, and therefore have a longer survival period.
Nakamura
K
K
Department of Biochemistry, Kitasato University School of Medicine, Kanagawa, Japan.
Kashiwazaki
S
S
Takagishi
K
K
Tsukamoto
Y
Y
Morohoshi
Y
Y
Nakano
T
T
Kimura
M
M
D000818:Animals; D000906:Antibodies / Q000032:analysis; D003094:Collagen / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D010084:Oxidation-Reduction; D011859:Radiography; D012217:Rheumatoid Factor / Q000032:analysis; D013045:Species Specificity
D000906:Antibodies; D003094:Collagen; D012217:Rheumatoid Factor