DNA variants of alpha-1-antitrypsin in rheumatoid arthritis with and without pulmonary complications.
Restriction fragment length polymorphisms (RFLPs) of alpha-1-antitrypsin were studied in 99 subjects with rheumatoid arthritis alone, 21 subjects with rheumatoid arthritis and pulmonary fibrosis, 26 subjects with rheumatoid arthritis and bronchiectasis, and 86 controls. No associations with either rheumatoid arthritis itself or with the associated pulmonary disorders were noted in this U.K. Caucasoid population.
Bate
A S
AS
Rheumatic Diseases Centre, Hope Hospital, Salford, Manchester, U.K.
Sidebottom
D
D
Cooper
R G
RG
Loftus
M
M
Chattopadhyay
C
C
Grennan
D M
DM
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics*; D001987:Bronchiectasis / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000235:genetics*; D000515:alpha 1-Antitrypsin / Q000235:genetics*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin