Degradation of human cartilage by synovial fluid but not cytokines in vitro.
Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
Hollander
A P
AP
Department of Pathology, University of Bristol, UK.
Atkins
R M
RM
Eastwood
D M
DM
Dieppe
P A
PA
Elson
C J
CJ
D001168:Arthritis / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000096:biosynthesis; D006621:Hip Joint; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D007719:Knee Joint; D009924:Organ Culture Techniques; D010003:Osteoarthritis / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D006025:Glycosaminoglycans; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha