Oncogenic transformation following sequential irradiations with monoenergetic neutrons and X rays.
Mouse C3H 10T1/2 cells were exposed sequentially to low doses (0.1 and 0.3 Gy) of monoenergetic neutrons (0.35, 0.45, 5.9, and 13.7 MeV) and 250-kVp X rays (1 and 3 Gy). The incidences of oncogenic transformation in the cells exposed to neutrons followed by X rays indicated that the effects of the individual radiations were simply additive. This supports the contention that risks associated with the two different radiation modalities may be considered to be additive.
Miller
R C
RC
Center for Radiological Research, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Geard
C R
CR
Marino
S A
SA
Richards
M
M
Randers-Pehrson
G
G
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D005214:Fast Neutrons; D051379:Mice; D009502:Neutrons; D014965:X-Rays