title: HLA class I gene polymorphism in genetic hemochromatosis.
abstract: The authors have studied HLA class I polymorphism in an attempt to identify a genomic marker of the hemochromatosis gene. Five enzymes were used (HindIII, EcoRI, EcoRV, PvuII, and HincII) in 47-106 unrelated patients and 71-91 controls. Both populations were HLA-typed. The relationship between the restriction fragments and HLA-A antigens was considered. Comparison of the two groups revealed a significantly high frequency of one 14 kb EcoRI fragment among the HLA-A3 hemochromatosis patients. The fragment hybridizes to an HLA-A specific probe but not to an HLA-B specific probe, and is associated with the hemochromatosis gene, which is itself associated with HLA-A3.
authors.affiliation: Laboratoire de Biochimie Médicale B, CHU Pontchaillou F, Rennes, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Jouanolle
authors.forename: J
authors.initials: J
authors.lastname: Yaouanq
authors.forename: M
authors.initials: M
authors.lastname: Blayau
authors.forename: M
authors.initials: M
authors.lastname: Périchon
authors.forename: R
authors.initials: R
authors.lastname: Fauchet
authors.forename: M P
authors.initials: MP
authors.lastname: Font
authors.forename: J Y
authors.initials: JY
authors.lastname: Le Gall
authors.forename: V
authors.initials: V
authors.lastname: David
mesh_terms: D006680:HLA Antigens / Q000235:genetics*; D006432:Hemochromatosis / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I