title: Development of macromolecular Sn(II) complex for preparation of 99Tcm radiopharmaceuticals.
abstract: Macromolecular Sn(II) complex (R-Sn) was developed using a chelating resin containing aminophosphonic acid groups as a reducing agent of 99Tcm(VII) in the preparation of 99Tcm radiopharmaceuticals. Since Sn(II) was bonded strongly to the resin by chelation, release of Sn from R-Sn was rarely observed in saline solution. 99Tcm labelling with a yield greater than 90% was performed by mixing R-Sn, 99Tcm pertechnetate solution and a ligand, such as human serum albumin and diethylenetriamine pentaacetic acid, for a short time. The 99Tcm radiopharmaceuticals were almost free from Sn(II) and the reducing activity of R-Sn was quite stable despite long-term storage without any special care.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Terahara
authors.forename: M
authors.initials: M
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Sugii
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: O
authors.initials: O
authors.lastname: Shimomura
authors.forename: A
authors.initials: A
authors.lastname: Kojima
authors.forename: S
authors.initials: S
authors.lastname: Tomiguchi
authors.forename: H
authors.initials: H
authors.lastname: Izunaga
mesh_terms: D000327:Adsorption; D002614:Chelating Agents; D046911:Macromolecular Substances; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D014001:Tin
chemical_list: D002614:Chelating Agents; D046911:Macromolecular Substances; D013668:Technetium Tc 99m Aggregated Albumin; D014001:Tin; D016284:Technetium Tc 99m Pentetate