title: Involvement of Sarcophaga lectin in the development of imaginal discs of Sarcophaga peregrina in an autocrine manner.
abstract: The imaginal discs of Sarcophaga were found not to develop normally in the presence of galactose, a hapten sugar of Sarcophaga lectin, or anti-Sarcophaga lectin antibody. Wing and leg discs cultured with these substances became morphologically abnormal and no imaginal discs reached the stage of terminal differentiation, even in the presence of 20-hydroxyecdysone. The development of the imaginal discs was shown to be autonomously regulated in an autocrine manner by Sarcophaga lectin; namely Sarcophaga lectin was secreted by the imaginal discs in the presence of 20-hydroxyecdysone, and the stimulus of self-induced Sarcophaga lectin seemed to be indispensable for further development of the imaginal discs. Sarcophaga lectin was originally found as a defense protein, but these results show that it plays independent roles in both defense and development.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Komano
authors.forename: S
authors.initials: S
authors.lastname: Natori
mesh_terms: D000818:Animals; D015153:Blotting, Western; D046508:Culture Techniques; D004175:Diptera / Q000254:growth & development*; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D019476:Insect Proteins; D007814:Larva; D037102:Lectins / Q000502:physiology*; D037181:Lectins, C-Type
chemical_list: C043030:20kDa lectin protein, Sarcophaga; D019476:Insect Proteins; D037102:Lectins; D037181:Lectins, C-Type; D005947:Glucose; D005690:Galactose