D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man.
By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.
Van Veldhoven
P P
PP
Katholieke Universiteit Leuven, Fakulteit geneeskunde, Belgium.
Brees
C
C
Mannaerts
G P
GP
D000326:Adrenoleukodystrophy / Q000201:enzymology; D000367:Age Factors; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D050804:D-Aspartate Oxidase; D006801:Humans; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008830:Microbodies / Q000201:enzymology*; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology; D013379:Substrate Specificity; D014018:Tissue Distribution; D015211:Zellweger Syndrome / Q000201:enzymology
D000594:Amino Acid Oxidoreductases; D050804:D-Aspartate Oxidase; C494102:DDO protein, human