title: Cardiac and splenic levels of norepinephrine and dopamine in copper deficient pigs and rats.
abstract: 1. Copper deficiency decreased the concentration and content of norepinephrine in the hearts of pigs and rats. 2. Concentration, but not content, of norepinephrine was decreased in spleen of copper-deficient pigs, while splenic norepinephrine levels in rats were not altered by copper deficiency. 3. Cardiac and splenic concentrations and contents of dopamine were elevated in copper-deficient pigs and rats. 4. Tissue concentrations of catecholamines and the magnitude of change due to copper deficiency were greater in pigs than rats.
authors.affiliation: Vitamin and Mineral Nutrition Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Agricultural Research Service, MD 20705.
authors.forename: H M
authors.initials: HM
authors.lastname: Schoenemann
authors.forename: M L
authors.initials: ML
authors.lastname: Failla
authors.forename: R W
authors.initials: RW
authors.lastname: Rosebrough
mesh_terms: D000818:Animals; D001835:Body Weight; D003300:Copper / Q000008:administration & dosage / Q000172:deficiency* / Q000378:metabolism; D004032:Diet; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism* / Q000473:pathology; D013552:Swine; D013950:Thymus Gland / Q000473:pathology
chemical_list: D003300:Copper; D004298:Dopamine; D009638:Norepinephrine