title: Studies on somatostatin with time-resolved spectroscopy and molecular dynamics simulations.
abstract: Somatostatin was studied by time-resolved fluorescence spectroscopy and by molecular dynamics simulations. The results obtained indicate the existence of mainly one conformation in DMSO, and the existence of several conformations in other solvents. Molecular dynamics simulations showed that the most important region for activity (residue 7-9) is also the most flexible region in the peptide.
authors.affiliation: Department of Medical Biophysics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Elofsson
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: R
authors.initials: R
authors.lastname: Rigler
mesh_terms: D003198:Computer Simulation; D004121:Dimethyl Sulfoxide; D011487:Protein Conformation; D012997:Solvents; D013004:Somatostatin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014364:Tryptophan
chemical_list: D012997:Solvents; D013004:Somatostatin; D014364:Tryptophan; D004121:Dimethyl Sulfoxide