Inhibition of postsurgical adhesions by liposomes containing nonsteroidal antiinflammatory drugs.
Intraperitoneal administration of liposomes containing the nonsteroidal antiinflammatory drugs (NSAID) ibuprofen or tolmetin was tested for their efficacy in the prevention of adhesion formation. Both NSAIDs were able to reduce adhesions in an animal model for moderate adhesion formation. However, tolmetin-containing liposomes were more efficacious than ibuprofen-containing liposomes in the reduction of adhesion formation following bilateral uterine abrasion and devascularization surgery.
Rodgers
K
K
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Girgis
W
W
diZerega
G S
GS
Bracken
K
K
Richer
L
L
D000818:Animals; D004337:Drug Carriers; D005260:Female; D007052:Ibuprofen / Q000008:administration & dosage* / Q000627:therapeutic use; D007263:Infusions, Parenteral; D008081:Liposomes; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011453:Prostaglandins / Q000096:biosynthesis; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control; D014046:Tolmetin / Q000008:administration & dosage* / Q000627:therapeutic use
D004337:Drug Carriers; D008081:Liposomes; D011453:Prostaglandins; D014046:Tolmetin; D007052:Ibuprofen