title: Isolation of nucleotide activated amino acid and peptide precursors of the pseudomurein of Methanobacterium thermoautotrophicum.
abstract: The following putative precursors of the pseudomurein were isolated from trichloroacetic acid extracts of Methanobacterium thermoautotrophicum: a uridine diphosphate activated derivative of glutamic acid and the uridine diphosphate activated peptides (see text). The activated glutamic acid residue and the three activated pepetides lack the glycan components N-acetylglucosamine and N-acetyltalosaminuronic acid present in the intact pseudomurein. In this case uridine diphosphate should be directly linked to the amino group of a glutamic acid residue, which represents a new mode of amino acid and peptide activation.
authors.affiliation: Abteilung für Angewandte Mikrobiologie, Universität Ulm.
authors.forename: E
authors.initials: E
authors.lastname: Hartmann
authors.forename: H
authors.initials: H
authors.lastname: König
authors.forename: O
authors.initials: O
authors.lastname: Kandler
authors.forename: W
authors.initials: W
authors.lastname: Hammes
mesh_terms: D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D019605:Euryarchaeota / Q000032:analysis*; D005971:Glutamates; D018698:Glutamic Acid; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis / Q000302:isolation & purification*; D010457:Peptidoglycan / Q000032:analysis* / Q000096:biosynthesis; D014530:Uridine Diphosphate
chemical_list: D005971:Glutamates; D009842:Oligopeptides; D010457:Peptidoglycan; D018698:Glutamic Acid; D014530:Uridine Diphosphate