title: Fine force instability: a quantitative measure of neuroleptic-induced dyskinesia in the hand.
abstract: The results of a new procedure for the quantification of tardive dyskinesia (TD) in the hand are reported. Fourier analyses were made of steady-state isometric force control in 41 neuroleptic-treated patients with and without hand TD. Results indicated that spectral analysis of isometric posture represents a reliable, sensitive, and valid measure of neuroleptic-induced dyskinesia.
authors.affiliation: Research and Psychiatry Services, V.A. Medical Center, San Diego, California 92161.
authors.forename: M P
authors.initials: MP
authors.lastname: Caligiuri
authors.forename: J B
authors.initials: JB
authors.lastname: Lohr
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D008838:Microcomputers; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects*; D009460:Neurologic Examination / Q000295:instrumentation*; D011597:Psychomotor Performance / Q000187:drug effects*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
chemical_list: D014150:Antipsychotic Agents