title: Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis.
abstract: We analyzed carnitine profiles in C3H-H-2 degrees strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al., 1988). Carnitine levels in serum, liver and muscle of mouse with fatty liver were markedly decreased in comparison with those of control mouse (littermates without fatty liver). This is a useful animal model to analyze the role of carnitine in lipid, amino acid and carbohydrate metabolism.
authors.affiliation: Second Department of Internal Medicine, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuwajima
authors.forename: N
authors.initials: N
authors.lastname: Kono
authors.forename: M
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Inui
authors.forename: S
authors.initials: S
authors.lastname: Kawata
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: J
authors.initials: J
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Saheki
mesh_terms: D000375:Aging; D000818:Animals; D002331:Carnitine / Q000097:blood / Q000172:deficiency* / Q000652:urine; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008817:Mice, Mutant Strains; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism*; D012016:Reference Values
chemical_list: D002331:Carnitine