[The role of the dopaminergic system and GABA-benzodiazepine- ionophore complex in the regulation of memory retrieval].
The spontaneous forgetting model has been used to demonstrate the possibility of the memory forgetten trace extraction under the dopamine reuptake blockade by nomifensine and bupropion, increase of its quantity by amfonelic acid, activation of the postsynaptic dopaminergic receptors by (+)3-PPP, blockade of the latter by (-)3-PPP, and under the blockade of separate links of the GABA-benzodiazepine-ionophore complex by bicuculline, picrotoxin, flumazepil and R015-3505. Effectiveness of the neuropharmacological actions improving the memory forgotten trace retrieval is shown to depend upon the duration of the spontaneous forgetting process. The presynaptic receptors are involved in the retrieval process control--improvement of the conditioned habit performance after forgetting due to the activation of presynaptic dopaminergic receptors by specific agonist (-)3-PPP is clearly correlated with the initial retrieval level. The above facts underlie a hypothesis about the neurochemical forgetting mechanisms.
Dubrovina
N I
NI
Il'iuchenok
R Iu
RIu
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D007476:Ionophores; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008960:Models, Psychological; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D000697:Central Nervous System Stimulants; D015259:Dopamine Agents; D007476:Ionophores; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A