Defective Candida opsonin and procidin function in patients with recurrent pyogenic infection: a common immunodeficiency.
Polymorphonuclear cell function tests were performed in 340 patients with recurrent unexplained infections. Serum-dependent defects in phagocytosis and intracellular killing of Candida albicans (Candida opsonin and procidin defects) were specifically associated with susceptibility to recurrent pyogenic infections, Candida opsonin defects occurring in 12.7% and Candida procidin defects in 20.8% of patients compared with 3.7% of healthy controls. Saccharomyces cerevisiae opsonin deficiencies were also found frequently in patients with recurrent infections, being present in 18.2% compared with 7.4% controls, although not specifically in those with pyogenic infection.
Parkin
J M
JM
Department of Immunology, St. Mary's Hospital Medical School, London, UK.
Bridges
J
J
Sloper
K S
KS
Warner
J O
JO
Pinching
A J
AJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000276:immunology*; D001798:Blood Proteins / Q000502:physiology*; D002175:Candida / Q000472:pathogenicity*; D002470:Cell Survival; D002648:Child; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins / Q000502:physiology*; D010587:Phagocytosis
D001798:Blood Proteins; C067495:Candida procidin; D009895:Opsonin Proteins