Potential gastrointestinal uses of somatostain and its synthetic analogue octreotide.
Octreotide is a long-acting analogue of somatostatin which has been FDA approved for symptomatic carcinoid syndrome and for vasoactive intestinal peptide-producing tumors. Somatostatin and octreotide have significant effects on gastrointestinal physiology which may be beneficial for a variety of disorders. This paper will review the currently available literature on the use of somatostatin and octreotide in non-neoplastic disorders of the gastrointestinal tract.
Grosman
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I
Long Island College Hospital, Brooklyn, New York.
Simon
D
D
D000595:Amino Acid Sequence; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D008969:Molecular Sequence Data; D015282:Octreotide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013004:Somatostatin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D013004:Somatostatin; D015282:Octreotide