Actions of a dopaminergic and beta 2-adrenergic agonist on O2 extraction by canine skeletal muscle.
We have shown that an unopposed stimulation of beta-vasodilator adrenoceptors can cause a decreased ability of skeletal muscle to extract O2 when O2 delivery was progressively lowered. The significance of this finding with respect to the application of dopexamine to cardiac failure or to any other condition that causes a decrease in peripheral O2 delivery, however, needs to be assessed when an appropriate increase in vasoconstrictor tone is allowed to occur.
Cain
S M
SM
Department of Physiology and Biophysics, University of Alabama, Birmingham 35294.
Bredle
D L
DL
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D009132:Muscles / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D000318:Adrenergic beta-Agonists; D015259:Dopamine Agents; C046318:dopexamine; D004298:Dopamine