Lack of weight gain associated with short-term astemizole treatment.
The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 +/- 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 +/- 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.
Ellison
M J
MJ
Department of Family Medicine, ECU School of Medicine, Greenville, NC 27858.
Horner
R D
RD
Lawler
F H
FH
Jones
J G
JG
D000328:Adult; D001066:Appetite / Q000187:drug effects; D016589:Astemizole; D001562:Benzimidazoles / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole