title: Beta-globin gene haplotypes in Polynesians are predominantly southern Chinese in type.
abstract: beta-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical HindIII restriction fragment length polymorphism detected with pRK29, a 3' beta-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the beta-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in origin.
authors.affiliation: Molecular Biology Laboratory, University of Sydney, NSW, Australia.
authors.forename: R J
authors.initials: RJ
authors.lastname: Trent
authors.forename: V
authors.initials: V
authors.lastname: Ferguson
authors.forename: M S
authors.initials: MS
authors.lastname: Hertzberg
authors.forename: J
authors.initials: J
authors.lastname: Rutherford
authors.forename: K N
authors.initials: KN
authors.lastname: Mickleson
mesh_terms: D002880:Chromosomes, Human, Pair 11; D003241:Consanguinity; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D014905:Independent State of Samoa; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D005914:Globins