title: Analysis of chromatid damage in G2 phase induced by heavy ions and X-rays.
abstract: The induction of chromatid aberrations was examined in Golden hamster embryo (GHE) cells 2 h after exposure to X-rays or heavy ions. Compared with X-rays the frequencies of gaps and deletions were almost one-half in the case of He ions, and much lower in cells irradiated with N ions. The induction of exchanges by He ions and N ions was also less than that by X-rays. The relative number of gaps, deletions and exchanges were 0.4, 0.5 and 0.4 for He ions, and 0.2, 0.2 and 0.4 for N ions. The mitotic indices were almost the same in X-irradiated and heavy-ion-exposed cells. Chromatid aberrations induced by heavy ions tended to persist longer than those induced by X-rays during successive culture passages after exposure. The present results suggest a difference in the quality of chromatid damage induced by X-rays and heavy ions.
authors.affiliation: School of Medicine, Yokohama City University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: I
authors.initials: I
authors.lastname: Kaneko
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D002460:Cell Line; D002842:Chromatids / Q000528:radiation effects*; D004735:Energy Transfer; D016195:G2 Phase / Q000528:radiation effects*; D006371:Helium; D007477:Ions; D009584:Nitrogen; D012062:Relative Biological Effectiveness; D012854:Sister Chromatid Exchange / Q000528:radiation effects*
chemical_list: D007477:Ions; D006371:Helium; D009584:Nitrogen