Replication intermediates as substrates for DNA rearrangements.
A model for the formation of DNA rearrangements in somatic cells is presented. Two double-strand breaks at the junctions between unreplicated DNA and newly replicated DNA generate four double-stranded DNA molecules that can recombine to form tandem duplications, inversions, deletions and extrachromosomal DNA circles.
Painter
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Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750.
Kapp
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LN
D002872:Chromosome Deletion; D007446:Chromosome Inversion; D004261:DNA Replication; D004270:DNA, Circular; D005057:Eukaryotic Cells / Q000648:ultrastructure; D015321:Gene Rearrangement; D008957:Models, Genetic
D004270:DNA, Circular