title: Cholinergic modulation of growth hormone-releasing hormone effects on growth hormone secretion in dementia.
abstract: An impairment of cholinergic and somatostatinergic neurotransmission have been reported in dementia. Both acetylcholine and somatostatin are involved in the regulation of growth hormone (GH) secretion. The effects of GH-releasing hormone (GHRH) 1-44 on GH release have been studied before and after the pretreatment with pyridostigmine or pirenzepine in subjects with senile dementia of the Alzheimer type, multi-infarct dementia and mixed dementia. The data have been compared with those obtained in an age-matched healthy control group. The GH response to GHRH is similar in the patients and in the controls, though the peak occurrence is significantly delayed in dementia. The cholinesterase inhibitor pyridostigmine enhances significantly the GH response to GHRH in both groups. The responses obtained in demented subjects are significantly larger than those found in the controls. Pirenzepine, a muscarinic receptor blocker, inhibits the GHRH effect on GH secretion in both groups. The findings may be interpreted in terms of an underlying impairment of the hypothalamic cholinergic neurotransmission, with an acetylcholine receptor supersensitivity that becomes apparent when the cholinergic tonus is enhanced by the inhibition of cholinesterase by pyridostigmine. No significant differences, due to the type of dementia, have been observed.
authors.affiliation: Department of Endocrinological and Metabolic Sciences, University of Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Murialdo
authors.forename: F
authors.initials: F
authors.lastname: Zerbi
authors.forename: U
authors.initials: U
authors.lastname: Filippi
authors.forename: P
authors.initials: P
authors.lastname: Tosca
authors.forename: S
authors.initials: S
authors.lastname: Fonzi
authors.forename: E
authors.initials: E
authors.lastname: Di Paolo
authors.forename: P
authors.initials: P
authors.lastname: Costelli
authors.forename: S
authors.initials: S
authors.lastname: Porro
authors.forename: A
authors.initials: A
authors.lastname: Polleri
authors.forename: F
authors.initials: F
authors.lastname: Savoldi
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D002799:Cholinergic Fibers / Q000502:physiology*; D003704:Dementia / Q000097:blood*; D015161:Dementia, Multi-Infarct / Q000097:blood; D015140:Dementia, Vascular / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007262:Infusions, Intravenous; D009483:Neuropsychological Tests; D010890:Pirenzepine; D011292:Premedication; D011729:Pyridostigmine Bromide; D011950:Receptors, Cholinergic / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology
chemical_list: D011950:Receptors, Cholinergic; D010890:Pirenzepine; D013004:Somatostatin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D011729:Pyridostigmine Bromide; D000109:Acetylcholine