Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium in rat and guinea pig.
The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats. Simultaneous administration of vitamins C and E in guinea pigs prevented the decrease of vitamin C levels provoked by the oxidative effects of Cr(VI). The results of the micronucleus test in bone marrow showed that it was vitamin C that caused the antimutagenic effect against bichromate, in both rats and guinea pigs. The effect of vitamin E was demonstrated only in an increase of the ratio of NCE to PCE, i.e., in a decrease of the cytotoxic but not the mutagenic effects of hexavalent chromium.
Chorvatovicová
D
D
Institute of Experimental Biology and Ecology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Ginter
E
E
Kosinová
A
A
Zloch
Z
Z
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004357:Drug Synergism; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009154:Mutation / Q000187:drug effects*; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D001205:Ascorbic Acid; D011192:Potassium Dichromate