title: trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
authors.affiliation: Neuroscience Research Division, Abbott Laboratories, Abbott Park, Illinois 60064.
authors.forename: M W
authors.initials: MW
authors.lastname: Holladay
authors.forename: C W
authors.initials: CW
authors.lastname: Lin
authors.forename: C S
authors.initials: CS
authors.lastname: May
authors.forename: D S
authors.initials: DS
authors.lastname: Garvey
authors.forename: D G
authors.initials: DG
authors.lastname: Witte
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.forename: C A
authors.initials: CA
authors.lastname: Wolfram
authors.forename: A M
authors.initials: AM
authors.lastname: Nadzan
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D006168:Guinea Pigs; D006909:Hydroxyproline; D007202:Indicators and Reagents; D008715:Methionine; D015394:Molecular Structure; D010179:Pancreas / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011949:Receptors, Cholecystokinin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013758:Tetragastrin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D007202:Indicators and Reagents; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C067196:3-propylproline; C067195:3-allylproline; D011392:Proline; D008715:Methionine; D006909:Hydroxyproline