title: Inhibition of human benzylamine oxidase (BzAO) by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
abstract: A sensitive assay for human plasma BzAO, involving the conversion of 14C-benzylamine to 14C-benzaldehyde, was developed. MPTP and several of its analogues were found to be competitive inhibitors of the enzyme. Ki values for the MPTP analogues in the presence of human plasma BzAO were determined. The analogues had a different rank order of inhibition of human plasma BzAO compared with the rank order of inhibition of bovine plasma BzAO found previously. MPTP and 1-methyl-4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP), which are potent nigrostriatal toxins, were weak inhibitors of human plasma BzAO.
authors.affiliation: Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, U.K.
authors.forename: A J
authors.initials: AJ
authors.lastname: Devlin
authors.forename: A R
authors.initials: AR
authors.lastname: Bhatti
authors.forename: A C
authors.initials: AC
authors.lastname: Williams
authors.forename: D B
authors.initials: DB
authors.lastname: Ramsden
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001595:Benzylamine Oxidase / Q000037:antagonists & inhibitors* / Q000097:blood; D002230:Carbidopa / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010300:Parkinson Disease / Q000097:blood / Q000201:enzymology*; D012642:Selegiline / Q000494:pharmacology
chemical_list: D015259:Dopamine Agents; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D012642:Selegiline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D001595:Benzylamine Oxidase; D002230:Carbidopa