Pneumothorax in a patient with Wegener's granulomatosis during treatment with immunosuppressive agents.
We present the case of a 16-year-old woman with Wegener's granulomatosis, who developed a pneumothorax while receiving treatment with cyclophosphamide and glucocorticoids. The lung was re-expanded by tube drainage, and the patient recovered completely while the immunosuppressive treatment was continued in combination with sulphamethoxazole-trimethoprim. A possible role for this antimicrobial drug in the treatment of Wegener's granulomatosis is briefly discussed.
Ogawa
M
M
First Department of Internal Medicine, Chiba University School of Medicine, Japan.
Azemoto
R
R
Makino
Y
Y
Mori
Y
Y
Ueda
S
S
Wakashin
M
M
Ohto
M
M
D000293:Adolescent; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D011030:Pneumothorax / Q000188:drug therapy / Q000209:etiology*; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D005938:Glucocorticoids; D003520:Cyclophosphamide; D014295:Trimethoprim; D013420:Sulfamethoxazole