[The effects of Cepharanthin on the recovery of hematopoietic stem cells after X-ray irradiation].
Administration of Cepharanthin (ceph) resulted in a significant acceleration of the recovery from leukopenia in 5-Gy X-ray irradiated mice. Then we examined the function of ceph on the recovery of hematopoietic stem cells after irradiation. The number of GM-CFU (granulocyte-macrophage committed stem cells) in the femur and spleen increased significantly in ceph compared to phosphate buffer solution administered groups. However, the time course of the recovery of GM-CFU did not differ between the two groups. These enhancing effects of ceph on GM-CFU were not observed when it was added to a bone marrow culture system. Therefore, the accelerating effects of the recovery from leukopenia after irradiation appears to be an indirect function of ceph.
Nemoto
K
K
Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
Yoshida
K
K
Nisimura
M
M
Seki
M
M
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D044182:Benzylisoquinolines; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D007958:Leukocyte Count; D007970:Leukopenia / Q000097:blood / Q000188:drug therapy; D008264:Macrophages / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; C006947:cepharanthine; D052117:Benzodioxoles