The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study.
We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose [18FDG]). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis.
Duboc
D
D
S. H. Fréderic Joliot, CEA, Orsay, France.
Kahan
A
A
Maziere
B
B
Loc'h
C
C
Crouzel
C
C
Menkès
C J
CJ
Amor
B
B
Strauch
G
G
Guérin
F
F
Syrota
A
A
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D011197:Potassium Radioisotopes; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D011197:Potassium Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D009543:Nifedipine