title: Mild fetal lateral cerebral ventriculomegaly: clinical course and outcome.
abstract: The neonatal, pathologic outcome and karyotypic abnormalities are reported for 44 fetuses with mild ventriculomegaly diagnosed antenatally. Seventeen of these 44 fetuses (39%) had other ultrasonographic defects, and five (12%) had abnormal karyotypes. Five pregnancies were electively aborted and three other fetuses died in the neonatal period. Twenty-six (72%) of the remaining 36 live-born neonates are developmentally and clinically normal at 3 to 18 months of age. Twenty-one of these 26 had isolated mild ventriculomegaly as the only ultrasonographic finding. The other 10 live-born infants are developmentally impaired, and five of these 10 had mild ventriculomegaly as the only prenatal ultrasonographic abnormality. In conclusion, these data show that fetuses with mild ventriculomegaly have a lower incidence of associated anomalies and a better outcome than fetuses with more severe ventricular dilatation, as reported in the literature. The majority of fetuses with mild ventriculomegaly as an isolated finding and a normal karyotype are developing normally.
authors.affiliation: Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: B
authors.initials: B
authors.lastname: Bromley
authors.forename: F D
authors.initials: FD
authors.lastname: Frigoletto
authors.forename: B R
authors.initials: BR
authors.lastname: Benacerraf
mesh_terms: D000015:Abnormalities, Multiple; D002552:Cerebral Ventricles / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011379:Prognosis; D016216:Ultrasonography, Prenatal