Autoimmunization against the neutrophil-specific NA1 antigen is associated with HLA-DR2.
A significant association of autoimmune neutropenia (AIN) in infants due to NA1-specific autoantibodies and HLA-DR2 is reported. Nineteen of 26 infants presenting with AIN and NA1 autoantibodies possessed the DR2 antigen, while only one out of six children with AIN, but non-NA1-specific autoantibodies, was DR2 positive. Furthermore, one adult patient with primary biliary cirrhosis and periods of neutropenia due to NA1 autoantibodies also carried the DR2 antigen. All DR2-negative patients were positive for DRw6. These findings indicate that a close relationship exists between autoimmunization against the NA1 antigen and HLA-DR2 and possibly also DRw6.
Bux
J
J
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, F.R.G.
Mueller-Eckhardt
G
G
Mueller-Eckhardt
C
C
D000368:Aged; D001323:Autoantibodies; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D005260:Female; D015802:HLA-DR2 Antigen / Q000235:genetics; D006801:Humans; D007114:Immunization; D007223:Infant; D008297:Male; D009503:Neutropenia / Q000235:genetics / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D015802:HLA-DR2 Antigen