title: P-glycoprotein and drug resistance in acute leukemias and in the blastic crisis of chronic myeloid leukemia.
abstract: The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P-glycoprotein can be expressed constitutively in some cases; c) P-glycoprotein does not appear to be the only mechanism responsible for resistance towards anthracyclines and Etoposide.
authors.affiliation: Unità di Ematologia, Università di Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Carulli
authors.forename: M
authors.initials: M
authors.lastname: Petrini
authors.forename: A
authors.initials: A
authors.lastname: Marini
authors.forename: F
authors.initials: F
authors.lastname: Vaglini
authors.forename: F
authors.initials: F
authors.lastname: Caracciolo
authors.forename: B
authors.initials: B
authors.lastname: Grassi
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001752:Blast Crisis / Q000097:blood* / Q000188:drug therapy; D004351:Drug Resistance; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000097:blood*; D009363:Neoplasm Proteins / Q000097:blood*; D009360:Neoplastic Cells, Circulating; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D014410:Tumor Stem Cell Assay
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins