title: Direct intralymphatic injection of radiolabeled 111In-T101 in patients with cutaneous T-cell lymphoma.
abstract: Direct intralymphatic administration of radiolabeled monoclonal antibody in targeting antigen-bearing lymphoma cells in regional lymph nodes of patients with cutaneous T-cell lymphoma was evaluated. Seven consecutive patients undergoing staging lymphangiography received intralymphatic infusions of 111In-T101 to evaluate lymph node involvement. This procedure was accomplished without significant complication. The 111In-T101 rapidly distributed throughout the regional lymphatic compartment and passed into the systemic circulation. Tumor-bearing sites in the inguinal-femoral lymph nodes retained from 0.42 to 4.8% of the injected dose of radiolabeled antibody. Three patients were upstaged to Stage IVA based on tumor involvement found after radiolymphoscintigraphy-directed biopsy of groin lymph nodes, selected because of intense radioactivity by gamma camera imaging. Compared with previously reported s.c. antibody administration, there was a marked reduction in the radioactive exposure of normal tissues at the injection sites in the lower extremities. Direct intralymphatic delivery of 111In-T101 appears to be a feasible, efficient method for delivering therapeutic doses of radiolabeled antibody.
authors.affiliation: National Cancer Institute, NCI-Navy Medical Oncology Branch, Naval Hospital, Bethesda, MD 20814.
authors.forename: J L
authors.initials: JL
authors.lastname: Mulshine
authors.forename: J A
authors.initials: JA
authors.lastname: Carrasquillo
authors.forename: J N
authors.initials: JN
authors.lastname: Weinstein
authors.forename: A M
authors.initials: AM
authors.lastname: Keenan
authors.forename: J C
authors.initials: JC
authors.lastname: Reynolds
authors.forename: J
authors.initials: J
authors.lastname: Herdt
authors.forename: P A
authors.initials: PA
authors.lastname: Bunn
authors.forename: E
authors.initials: E
authors.lastname: Sausville
authors.forename: J
authors.initials: J
authors.lastname: Eddy
authors.forename: J D
authors.initials: JD
authors.lastname: Cotelingam
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000627:therapeutic use*; D007267:Injections; D007279:Injections, Subcutaneous; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000528:radiation effects; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes