title: Efficacy of vancomycin plus tobramycin as antiperitonitis regimen for patients on CAPD.
abstract: From October 1985 to August 1989, 55 episodes of peritonitis were treated with intraperitoneal (i.p.) use of Vancomycin (V) and Tobramycin (T), in 35 patients (18 males, 17 females). After three rapid IL peritoneal exchanges, the pts received i.p. loading dose of V500 mg/L and an intramuscular dose of T 1.7 mg/Kg, followed by four IL exchanges, with addition of V15 mg/L and T8 mg/L. The length of treatment was 10 days for all pts. The continued administration of V or T as the simple antibiotic regimen was based on the antibiogram, while the combination of both antibiotics was used in negative cultures. Recurrence of peritonitis was seen in 3 episodes (5.4%). No side effects were seen during the therapy. These results indicate that the i.p. use of Vancomycin plus Tobramycin are an appropriate antiperitonitis regimen in the treatment of CAPD peritonitis.
authors.affiliation: Democritus University of Thrace, General District Hospital, Alexadroupolis, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Vargemezis
authors.forename: E
authors.initials: E
authors.lastname: Thodis
authors.forename: P
authors.initials: P
authors.lastname: Pasadakis
authors.forename: G
authors.initials: G
authors.lastname: Martinis
authors.forename: E
authors.initials: E
authors.lastname: Kousta
mesh_terms: D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use; D014640:Vancomycin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D014640:Vancomycin; D014031:Tobramycin