[Tumor markers in liver metastases of colorectal carcinoma].
Colorectal cancer is a potentially curable tumour when diagnosed in the early stages. In order to improve the results obtained up to now, we propose application of a diagnostic program among patients who undergo curative resection for colorectal adenocarcinoma, which would consist of using a panel of tumor markers, in combination with endoscopic, histologic and ultrasonographic diagnostic methods. For this study we studied 105 patients, divided into two groups: A) Group 1: 30 control patients. B) Group 2: 75 patients diagnosed as having colorectal cancer. We performed the preoperative determination of a series of tumor markers (CEA, CA 19.9, GGT and PHI), endoscopy/biopsy and hepatic ultrasonography on these patients. Our results suggest that the design of the preoperative diagnostic program makes early detection of hepatic metastases possible. The tumor marker panel combination provided a visible increase in sensitivity for detecting hepatic metastases.
Moreno Sierra
J
J
Hospital Universitario San Carlos, Facultad de Medicina, Universidad Complutense de Madrid.
Vincent
E
E
Gea
M
M
Ortega
M D
MD
Borque
M
M
Madrigal
J
J
Pimentel
C
C
Represa
J
J
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary*; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000097:blood; D004796:Clinical Enzyme Tests; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D008875:Middle Aged; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005723:gamma-Glutamyltransferase; D005956:Glucose-6-Phosphate Isomerase