title: Acid-base equilibria of beta-blockers in acetonitrile.
abstract: The acid-base equilibria of a series of beta-adrenoceptor blocking drugs in acetonitrile have been studied, and pKHB+ values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of beta-adrenoceptor blocking drugs.
authors.affiliation: Department of Analytical Chemistry, University of Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Barbosa
authors.forename: V
authors.initials: V
authors.lastname: Sanz-Nebot
authors.forename: M E
authors.initials: ME
authors.lastname: Torrero
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D007202:Indicators and Reagents; D007700:Kinetics; D011199:Potentiometry
chemical_list: D000097:Acetonitriles; D000319:Adrenergic beta-Antagonists; D007202:Indicators and Reagents