[The effect of catecholaminergic agents on the efficacy of immunostimulants].
The influence of combinations of immunostimulants (prodigiosin, methyluracil, levamisole) and catecholaminergic agents (dopamine, haloperidol, noradrenaline, phentolamine, isoproterenol, propranolol) on the results of antibiotic therapy of acute generalized Proteus infection and primary immune response to ram erythrocytes was studied on outbred albino mice. It was established that the agents influencing dopaminergic, alpha- and beta-adrenergic receptors can in some cases change the efficiency of the studied immunostimulants. The direction and degree of their action depend on the administration schedule.
Shigaev
N I
NI
Lazareva
D N
DN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002395:Catecholamines / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D011512:Proteus Infections / Q000188:drug therapy / Q000276:immunology / Q000401:mortality; D011513:Proteus mirabilis; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D002395:Catecholamines; D015259:Dopamine Agents