title: Interaction of cholinergic and glutamatergic transmission in the hippocampus: an in vitro autoradiographic receptor analysis.
abstract: Quantitative in vitro receptor autoradiography was used to examine the effect of acute scopolamine administration on specific binding to components of the N-methyl-D-aspartate (NMDA) receptor complex in four regions of mouse hippocampus. The binding of [3H]glycine to the strychnine-insensitive site was increased 1 h after administration of scopolamine hydrobromide (10 mg/kg) in the ventral dentate gyrus. The study suggests that rapid alterations in strychnine-insensitive glycine binding can occur in response to cholinergic perturbations. Moreover, these data suggest a delicate interaction between cholinergic and glutamatergic projections in the hippocampus.
authors.affiliation: Psychiatry Service, Department of Veterans Affairs Medical Center, Washington, DC 20422.
authors.forename: S I
authors.initials: SI
authors.lastname: Deutsch
authors.forename: D M
authors.initials: DM
authors.lastname: Panchision
authors.forename: R B
authors.initials: RB
authors.lastname: Rosse
authors.forename: M R
authors.initials: MR
authors.lastname: Novitzki
authors.forename: L P
authors.initials: LP
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Mastropaolo
mesh_terms: D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051379:Mice; D010275:Parasympathetic Nervous System / Q000502:physiology*; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D005971:Glutamates; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D012601:Scopolamine; D013331:Strychnine