The structure of the homeodomain and its functional implications.
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
Gehring
W J
WJ
University of Basel, Switzerland.
Müller
M
M
Affolter
M
M
Percival-Smith
A
A
Billeter
M
M
Qian
Y Q
YQ
Otting
G
G
Wüthrich
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000033:anatomy & histology / Q000235:genetics*; D005801:Genes, Homeobox; D008969:Molecular Sequence Data; D011487:Protein Conformation
D004247:DNA