title: Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters.
abstract: Intrapancreatic and subcutaneous (SC) inoculation of cultured pancreatic cancer cells, derived from an induced primary pancreatic cancer in a Syrian hamster, resulted in tumor take in all recipient hamsters. The intrapancreatic allografts grew rapidly, were invasive, and metastasized into the lymph nodes and liver in 2 of 9 cases. In comparison, SC tumors grew relatively slower and formed a large encapsulated mass without invasion and metastases. Histologically, tumors of both sites showed fairly well-differentiated adenocarcinomas of ductal/ductular type resembling the induced primary cancer. Similar to the primary induced pancreatic cancers, tumor cells of both allografts expressed blood-group-related antigens, including A, B, H, Le(b), Le(y), Le(x), and tumor-associated antigen TAG-72. The tumor cells did not express Le(a), CA 19-9, 17-1A, or DU-PAN-2. The expression of these antigens was retained in the metastases and presented the same patterns of reactivity as the allografts. Thus intrapancreatic transplantation provides a rapid model for production of pancreatic cancer with morphologic similarities to human pancreatic cancer.
authors.affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198-6805.
authors.forename: H
authors.initials: H
authors.lastname: Egami
authors.forename: T
authors.initials: T
authors.lastname: Tomioka
authors.forename: M
authors.initials: M
authors.lastname: Tempero
authors.forename: D
authors.initials: D
authors.lastname: Kay
authors.forename: P M
authors.initials: PM
authors.lastname: Pour
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D006224:Cricetinae; D007150:Immunohistochemistry; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000637:transplantation
chemical_list: D000951:Antigens, Neoplasm