[The effect of cofactors on microsomal S-oxygenation of oxyprothepine].
Oxyprothepine in the medium of the microsomal fraction of the rat liver is biotransformed to the corresponding metabolites originating by oxidation of both sulfur atoms. The formation of S-oxygenation products is bound to the presence of NADPH, with a marked synergism with NADH. Induction with phenobarbital increases the formation of the individual metabolites.
Pauliková
I
I
Katedra biochémie a mikrobiológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Helia
O
O
D000818:Animals; D003988:Dibenzothiepins / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology*; D009249:NADP / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D003988:Dibenzothiepins; D009243:NAD; D009249:NADP; D010634:Phenobarbital