The effects of clozapine on rat mast cells are different from those of benzodiazepines.
1. Clozapine caused dose-dependent inhibition of the release of [14C]serotonin and 45Ca uptake by purified rat peritoneal mast cells activated by concanavalin A, which is similar to the effect of benzodiazepines. 2. However, it had little ability to displace [3H]diazepam binding to mast cells.
Sano
T
T
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
Uchida
M K
MK
Suzuki-Nishimura
T
T
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001667:Binding, Competitive / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D003024:Clozapine / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D003975:Diazepam / Q000378:metabolism; D003984:Dibenzazepines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D014151:Anti-Anxiety Agents; D002132:Calcium Radioisotopes; D003984:Dibenzazepines; D003208:Concanavalin A; D012701:Serotonin; D000001:Calcimycin; D003024:Clozapine; D003975:Diazepam; D002118:Calcium