title: Differentiation between extrahepatic and intrahepatic cholestasis by discriminant analysis.
abstract: Discriminant analysis was used to differentiate between extrahepatic biliary atresia and intrahepatic cholestasis. Among the ten laboratory variables tested, three (gamma-glutamyl transpeptidase, alkaline phosphatase and total serum bilirubin) were useful in the differential diagnosis. gamma-Glutamyl transpeptidase contributed most to the discrimination (85%). From a population study of 28 babies with extrahepatic biliary atresia and 24 infants with intrahepatic cholestasis, the procedure achieved a diagnostic accuracy and specificity of 92.9% and an efficiency of 92.3%. The jackknife procedure has also confirmed that the mathematical model was robust for discriminant analysis and therefore it may be valid for screening infants with cholestasis for early surgical intervention. Discriminant analysis is a useful adjunct for differentiation between intrahepatic cholestasis and extrahepatic biliary atresia.
authors.affiliation: Department of Paediatrics, National University Hospital, National University of Singapore, Hong Kong.
authors.forename: K P
authors.initials: KP
authors.lastname: Fung
authors.forename: S P
authors.initials: SP
authors.lastname: Lau
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001656:Biliary Atresia / Q000150:complications / Q000175:diagnosis; D001663:Bilirubin / Q000097:blood; D001651:Cholestasis, Extrahepatic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007223:Infant; D008111:Liver Function Tests; D008297:Male; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001663:Bilirubin