[The effect of cardioactive drugs on the proteolytic activity of the rat heart muscle].
Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both activating and inhibitory effects on proteolytic activity in rat heart tissue extract. The beta-adrenoblocking agents did not affect distinctly the activity of partially purified cathepsin D and Ca2(+)-dependent neutral protease from myocardium. Nifedipine inhibited cathepsin D by 50% and Ca2(+-dependent neutral protease--by 75%; phenoptine inhibited also the latter enzyme by 30%.
Karapetian
R G
RG
Akopian
T N
TN
Oganisian
A I
AI
Oganesian
S S
SS
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D014020:Tissue Extracts / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D014020:Tissue Extracts; D010447:Peptide Hydrolases