Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice.
DL-beta-N-methylamino-alanine (DL-BMAA; 1-10 mumol i.c.v.) in mice induced a syndrome of: ataxia, ptosis, scratching, jumping, myoclonic jerks, clonic muscle spasms and tonic seizure, which was unaffected by pretreatment with D(-)-4-(3-phosphonoprop-2-enyl)-piperazine-2-carboxylate (D(-)-CPPene; i.p.), or by co-administration of gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS with DL-BMAA; i.c.v.). Pretreatment with 1-(aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzodiazepine (GYKI 52466; i.v.) decreased the incidence of clonic seizures for DL-BMAA, kainic acid and RS-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (RS-AMPA; i.c.v.). These results suggest an involvement of the AMPA/quisqualate subtype of excitatory amino acid receptors in acute BMAA toxicity.
Smith
S E
SE
Department of Neurology, Institute of Psychiatry, London, U.K.
Meldrum
B S
BS
D000599:Amino Acids, Diamino / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology; D000087522:Cyanobacteria Toxins; D005973:Glutamine / Q000031:analogs & derivatives / Q000494:pharmacology; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D016202:N-Methylaspartate / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D000599:Amino Acids, Diamino; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000087522:Cyanobacteria Toxins; D009943:Organophosphorus Compounds; D010879:Piperazines; D011955:Receptors, Drug; D016194:Receptors, N-Methyl-D-Aspartate; D005973:Glutamine; C061950:GYKI 52466; C001824:beta-N-methylamino-L-alanine; D001569:Benzodiazepines; C065286:SDZ EAA 494; D007051:Ibotenic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; C042626:gamma-glutamylaminomethylsulfonic acid; D007608:Kainic Acid