Bivalent effects of human growth hormone in experimental myocardial infarcts. Protective when administered alone and aggravating when combined with beta blockers.
Human growth hormone (hGH) administered alone revealed itself as a useful drug to prevent ventricular aneurysm formation in experimental myocardial infarctions in rats and is also able to diminish and change the usually expected pattern of wall necrosis. A protective action on the collagen framework of myocytes has been confirmed as one of the main causes responsible for the above mentioned findings. There are other positive metabolic actions on the myocardial cell although not completely known yet. These actions are revealed by an atypical picture of infarction which appears regionally reduced and with a patchy intracellular distribution. In an opposite fashion, when hGH was administered together with beta blockers, a rapid and extensive deleterious action occurred at the ventricular wall, a very high incidence of ventricular aneurysms and an increased extension of myocardial infarcts were the most outstanding features. The histologic picture in this series resembles that of a rapidly evolving diabetic cardiomyopathy.
Castagnino
H E
HE
Hospital Escuela José de San Martin, Departamento de Medicina, Universidad de Buenos Aires, Argentina.
Milei
J
J
Toranzos
F A
FA
Weiss
V
V
Beigelman
R
R
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D003094:Collagen / Q000648:ultrastructure; D004357:Drug Synergism; D013006:Growth Hormone / Q000494:pharmacology*; D006322:Heart Aneurysm / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D000319:Adrenergic beta-Antagonists; D013006:Growth Hormone; D003094:Collagen