title: Effect of phenytoin on plasma clozapine concentrations in two patients.
abstract: Little is known about interactions of other drugs with the recently marketed antipsychotic clozapine. Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed.
authors.affiliation: Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
authors.forename: D D
authors.initials: DD
authors.lastname: Miller
mesh_terms: D000328:Adult; D003024:Clozapine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology
chemical_list: D010672:Phenytoin; D003024:Clozapine