Endothelin action on goat cerebral arteries.
Cumulative application of endothelin-1 (human) markedly constricted goat isolated cerebral arteries in a concentration-dependent manner. Contractile responses were not affected by removal of endothelial cells. Removal of extracellular calcium or addition of the calcium channel blocker nicardipine (10(-7) M) failed to abolish responses to endothelin. The results suggest that the endothelium-independent constriction of cerebral arteries produced by endothelin cannot be explained solely by voltage-dependent calcium channels. The contractile responses are likely to be mediated by stimulation of specific receptors for this peptide.
Vila
J M
JM
Departamento de Fisiología, Universidad de Valencia, Spain.
Martín de Aguilera
E
E
Martinez
M C
MC
Rodriguez
M D
MD
Irurzun
A
A
Lluch
S
S
D000818:Animals; D002118:Calcium / Q000502:physiology; D002536:Cerebral Arteries / Q000187:drug effects; D016232:Endothelins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006041:Goats; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009529:Nicardipine / Q000494:pharmacology
D016232:Endothelins; D009529:Nicardipine; D002118:Calcium