Sinemet CR in Parkinson's disease.
Sinemet CR, a controlled release carbidopa/levodopa preparation, was compared to conventional carbidopa/levodopa in a double blind, placebo-controlled trial. Comparable clinical benefits and adverse effects were noted with the two medications. However significantly less frequent dosing was necessary with Sinemet CR.
Pfeiffer
R F
RF
University of Nebraska Medical Center, Section of Neurology, Omaha 68198-2045.
Wilken
K E
KE
Glaeske
C S
CS
Hofman
R
R
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002230:Carbidopa / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D010919:Placebos
D000978:Antiparkinson Agents; D004338:Drug Combinations; D010919:Placebos; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa