Transport of organochlorine residues in the rat and human blood.
Organochlorine residues (OCR)2 are poorly soluble in water and are transported in the organism bound by the blood components. The distribution among blood fractions (cells/plasma, lipoproteins/rest of plasma proteins) were variable depending on the residue (HCB, p p'-DDE, HCH, Aroclor 1260, PCP) and on the species (rat, man). Differences were not found between in vivo (after oral single dosing) and in vitro (blood incubation) experiments. Results indicated a high affinity of organochlorine residues for lipoproteins; however, binding to blood carriers was very weak as demonstrated by the rapid release of residues by elution through a reverse phase column. The effects of residue binding to blood components on the distribution kinetics to tissues are discussed.
Gómez-Catalán
J
J
Unitat de Medicina Legal, Facultat de Medicina, Hospital Clinic i Provincial, Universitat de Barcelona, Spain.
To-Figueras
J
J
Rodamilans
M
M
Corbella
J
J
D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics*; D008074:Lipoproteins / Q000378:metabolism; D010573:Pesticide Residues / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D001798:Blood Proteins; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D008074:Lipoproteins; D010573:Pesticide Residues