Penicillin-induced hemolytic anemia and acute hepatic failure following treatment of tetanus in a horse.
Acute, severe hemolytic anemia occurred in a horse being treated for tetanus with intravenous penicillin and tetanus antitoxin. During treatment, the horse developed a positive direct antiglobulin test and a high titer (maximum 1:1024) of IgG anti-penicillin antibody. The horse recovered from the tetanus and penicillin induced hemolytic anemia, but later developed acute hepatic failure, probably resulting from the administration of equine origin tetanus antitoxin.
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Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University Ithaca 14853.
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D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D003298:Coombs Test / Q000662:veterinary; D003937:Diagnosis, Differential; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006734:Horse Diseases / Q000188:drug therapy / Q000209:etiology*; D006736:Horses; D007074:Immunoglobulin G / Q000032:analysis; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D012713:Serum Sickness / Q000209:etiology / Q000662:veterinary*; D013742:Tetanus / Q000188:drug therapy*; D013743:Tetanus Antitoxin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D013743:Tetanus Antitoxin; D010402:Penicillin G Procaine