[The significance of gamma-glutamyltransferase in the evaluation of the results of chemotherapy of liver metastasis].
The serum concentration of gamma-glutamyltransferase (gamma-GT) was serially measured in 26 cancer patients undergoing chemotherapy for liver metastases. 20 patients were studied retrospectively and 6 prospectively with emphasis on the first few days of cytostatic treatment. The gamma-GT determinations during the first days of treatment gave no indication of the prognosis of remission. Serial measurements during treatment do, however, serve to objectify the success of the chemotherapy. In most patients the gamma-GT concentrations paralleled the general condition as well as palpation and ultrasound examination of the liver. Direct interactions of cytotoxic drugs with gamma-GT could not be demonstrated. gamma-GT determinations are therefore of help in phase II studies in evaluating new drugs for their cytostatic activity against liver metastases.
Külling
D
D
Departement für Innere Medizin, Universitätsspital Zürich.
Sauter
C
C
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction; D012189:Retrospective Studies; D005723:gamma-Glutamyltransferase / Q000097:blood*
D000970:Antineoplastic Agents; D005723:gamma-Glutamyltransferase