title: Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice.
abstract: Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7) from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs.
authors.affiliation: Israel Institute for Biological Research, Ness-Ziona.
authors.forename: Y
authors.initials: Y
authors.lastname: Ashani
authors.forename: S
authors.initials: S
authors.lastname: Shapira
authors.forename: D
authors.initials: D
authors.lastname: Levy
authors.forename: A D
authors.initials: AD
authors.lastname: Wolfe
authors.forename: B P
authors.initials: BP
authors.lastname: Doctor
authors.forename: L
authors.initials: L
authors.lastname: Raveh
mesh_terms: D000110:Acetylcholinesterase / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D002091:Butyrylcholinesterase / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004347:Drug Interactions; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011041:Poisoning / Q000517:prevention & control; D011806:Quinolinium Compounds / Q000633:toxicity; D012999:Soman / Q000506:poisoning / Q000633:toxicity*; D013997:Time Factors
chemical_list: D002800:Cholinesterase Inhibitors; D011806:Quinolinium Compounds; C044294:7-((methylethoxyphosphinyl)oxy)-1-methylquinolinium; D012999:Soman; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase