title: Homozygous condition for a BrdU-requiring fragile site on chromosome 12.
abstract: A rare BrdU-sensitive fragile site, designated FRA12C*RQ24.2 has a relatively high frequency in the normal population. It can be demonstrated in a heterozygous and homozygous condition. There is no evidence that a phenotypic abnormality is associated with the expression of this site. A comparison with the fragile site FRA10B*RQ25.2 has revealed common features with FRA12C*RQ24.2.
authors.affiliation: Institut für Humangenetik und Anthropologie der Universität, Freiburg, Federal Republic of Germany.
authors.forename: I
authors.initials: I
authors.lastname: Voiculescu
authors.forename: E
authors.initials: E
authors.lastname: Back
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002881:Chromosomes, Human, Pair 12; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008677:Metaphase
chemical_list: D001973:Bromodeoxyuridine