Time course of the effect of intravenous dimetindene maleate.
In order to evaluate the time course of its effects, dimetindene maleate has been investigated in a histamine provocation model in man. Eight healthy male volunteers were treated i.v. with 4 mg dimetindene maleate or sodium chloride solution in a double blind, cross over study. Intracutaneous histamine injections were given at -1, 2, 5, 14, 17, 20, 23, 26, and 29 h following drug administration and the areas of flares and wheals were measured after 5, 10, 20, and 30 min. There was strong inhibition of the development both of flares and wheals, which was more pronounced for the former. Baseline adjusted areas under the curve differed significantly following drug and placebo treatment. The maximum effect was observed at 2 h. The mean residence time of the inhibitory effect was calculated to be approximately 13 h compared to the mean residence time of dimetindene in blood of approximately 5 h, which indicates a non-linear relationship between blood level and effect.
Rehn
D
D
Zyma GmbH, Hauptabteilung Medizin und Entwicklung, München, FRG.
Geissler
H
H
Schönbrunn
U
U
Lukas
H
H
Hennings
G
G
D000328:Adult; D004115:Dimethindene / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012882:Skin Tests
D006634:Histamine H1 Antagonists; D004115:Dimethindene