title: Identification of the ancestral haplotype for apolipoprotein B suggests an African origin of Homo sapiens sapiens and traces their subsequent migration to Europe and the Pacific.
abstract: The probable ancestral haplotype for human apolipoprotein B (apoB) has been identified through immunological analysis of chimpanzee and gorilla serum and sequence analysis of their DNA. Moreover, the frequency of this ancestral apoB haplotype among different human populations provides strong support for the African origin of Homo sapiens sapiens and their subsequent migration from Africa to Europe and to the Pacific. The approach used here for the identification of the ancestral human apoB haplotype is likely to be applicable to many other genes.
authors.affiliation: Department of Genetics, University of Wisconsin, Madison.
authors.forename: J
authors.initials: J
authors.lastname: Rapacz
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: E
authors.initials: E
authors.lastname: Butler-Brunner
authors.forename: M J
authors.initials: MJ
authors.lastname: Wu
authors.forename: J O
authors.initials: JO
authors.lastname: Hasler-Rapacz
authors.forename: R
authors.initials: R
authors.lastname: Butler
authors.forename: V N
authors.initials: VN
authors.lastname: Schumaker
mesh_terms: D000349:Africa / Q000208:ethnology; D000595:Amino Acid Sequence; D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics*; D001208:Asia / Q000208:ethnology; D001315:Australia / Q000208:ethnology; D001483:Base Sequence; D005075:Biological Evolution; D005006:Ethnicity; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency; D014644:Genetic Variation; D006071:Gorilla gorilla / Q000235:genetics; D006239:Haplotypes; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics; D011110:Polymorphism, Genetic; D044469:Racial Groups; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001055:Apolipoproteins B