title: Potentiation of glutamate-activated currents in isolated hippocampal neurons.
abstract: "Fast chemical stimulation" was shown to induce potentiation of glutamate-activated currents in neurons isolated from rat hippocampus. A fast application system allowed solution changes up to a rate of 20 Hz. In Mg2(+)-free solution, the response to glutamate application immediately after repetitive stimulation with glutamate plus glycine was increased by 25%-88%, returning to control levels over 10-15 min. Enhancement of glutamate-induced currents was also seen after stimulation with solutions containing aspartate or NMDA plus glycine. Aspartate-induced currents were not potentiated. These and other observations demonstrate that in a purely "postsynaptic" system, short-term potentiation can be induced and is mediated via NMDA receptors whereas the potentiated current is carried via non-NMDA glutamate receptor channels.
authors.affiliation: Institute of General Pathology and Pathological Physiology, Moscow, Union of Soviet Socialist Republics.
authors.forename: Y I
authors.initials: YI
authors.lastname: Zilberter
authors.forename: V V
authors.initials: VV
authors.lastname: Uteshev
authors.forename: S N
authors.initials: SN
authors.lastname: Sokolova
authors.forename: L G
authors.initials: LG
authors.lastname: Motin
authors.forename: H H
authors.initials: HH
authors.lastname: Eremjan
mesh_terms: D000818:Animals; D002469:Cell Separation; D004553:Electric Conductivity; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D016202:N-Methylaspartate / Q000502:physiology; D009474:Neurons / Q000502:physiology*
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D016202:N-Methylaspartate