Hyperoxia and salicylate metabolism in rats.
Following the administration of aspirin to rats by gavage, both 2,3- and 2,5-dihydroxybenzoate appeared in the plasma. The concentration of the 2,3-dihydroxybenzoate was significantly higher in animals exposed to 100% O2 for 60 h than in air breathing controls. These data are evidence that increased salicylate hydroxylation is associated with oxidative stress.
O'Connell
M J
MJ
Division of Anaesthesia, Clinical Research Centre, Harrow, Middlesex, UK.
Webster
N R
NR
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005609:Free Radicals; D062385:Hydroxybenzoates / Q000097:blood; D006900:Hydroxylation; D010100:Oxygen / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000378:metabolism*
D005609:Free Radicals; D062385:Hydroxybenzoates; D012459:Salicylates; D010100:Oxygen