NMDA antagonists interact with 5-HT-stimulated phosphatidylinositol metabolism and impair passive avoidance retention in the rat.
The NMDA receptor antagonists APV (5 micrograms/10 microliters/rat i.c.v.) or ketamine (12.5 mg/kg i.p.), administered 5 min before training, decreased the retention of a passive avoidance conditioning. In hippocampal or cortical slices of APV- and ketamine-treated rats, 5-HT-stimulated phosphoinositide metabolism was potentiated. It is suggested that excitatory amino acids could modulate the mechanism operative in signal transduction of serotonin; this interaction could play a role in memory retention.
Gandolfi
O
O
Institute of Pharmacology, University of Bologna, Italy.
Dall'Olio
R
R
Roncada
P
P
Montanaro
N
N
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*; D012153:Retention, Psychology / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*
D010716:Phosphatidylinositols; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D012701:Serotonin; D007649:Ketamine; D015763:2-Amino-5-phosphonovalerate