Chloral hydrate anesthesia antagonizes the neurotoxicity of 3,4-methylenedioxymethamphetamine.
We report that maintaining rats under chloral hydrate anesthesia for the first 3 h following the administration of 3,4-methylenedioxymethamphetamine (MDMA) blocks the decrease in forebrain concentrations of 5-hydroxytryptamine (5-HT) measured 1 week later. In contrast, the acute effect of MDMA (3 h) on forebrain 5-HT was not altered by the anesthetic. This protective effect of chloral hydrate was not due to an anesthetic-induced hypothermia but may be related to the hypothesized role of dopamine in the neurotoxic effects of MDMA.
Schmidt
C J
CJ
Merrell Dow Research Institute, Cincinnati, OH 45215.
Black
C K
CK
Abbate
G M
GM
Taylor
V L
VL
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity; D000758:Anesthesia; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002697:Chloral Hydrate / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D002697:Chloral Hydrate; D015104:3,4-Methylenedioxyamphetamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine