Effect of flutoprazepam on skills essential for driving motor vehicles.
The effects of the 1,4-benzodiazepine derivative flutoprazepam on the skills essential for driving motor vehicles were tested 2.5 h after intake of 1 x 2 mg and 1 x 4 mg, comparing with placebo. 18 healthy subjects who had homogeneous results in psychological/physical tests took part in the study. The study had a double-blind, randomized crossover design with 7-day washout periods. 2.5 h after intake of 4 mg flutoprazepam, the ability to drive was impaired. Only a very slight reduction in skill was found at the same time under the influence of 2 mg of the drug.
Moser
L
L
Institut für Arzneimittelprüfung, Forschungsstelle der Gesellschaft für Ursachenforschung bei Verkehrsunfällen, Cologne, Fed. Rep. of Germany.
Macciocchi
A
A
Plum
H
H
Bückmann
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001334:Automobile Driving; D001570:Benzodiazepinones / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D011597:Psychomotor Performance / Q000187:drug effects*; D011897:Random Allocation
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; C029163:flutoprazepam