A case of maternity testing: exclusion by polymorphic VNTR markers of DNA.
The genetic markers of a Korean woman and her allegedly adopted child were compared to test her maternity. None of 21 conventional markers, including 8 red cell antigens, 6 red cell enzymes, and 7 serum proteins, excluded the maternity. These results indicate a maternal probability of 0.31 which was too low to conclude the true maternity. Human leukocyte antigen (HLA)-A, -B, -C and -DR haplotyping was also uninformative in this case. The maternity was consequently excluded by the observation of a difference in 2 of 5 variable number of tandem repeat (VNTR) markers.
Akane
A
A
Department of Legal Medicine, Shimane Medical University, Izuma, Japan.
Nakajima
H
H
Shiono
H
H
Matsubara
K
K
Yamada
M
M
Nakagome
Y
Y
D004247:DNA / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D009035:Mothers; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid
D005819:Genetic Markers; D004247:DNA