title: Direct and indirect modulation of neuronal calcium currents by G-protein activation.
abstract: Evidence is presented for modulation of the various components of neuronal Ca2+ currents by G-proteins and by gamma-aminobutyric acid B (GABAB) receptor activation. The mechanism of these interactions and the possible involvement of second messengers is discussed. The role of inhibition of Ca2+ channels in presynaptic inhibition of neurotransmitter release is examined.
authors.affiliation: Department of Pharmacology, St George's Hospital Medical School, London, U.K.
authors.forename: A C
authors.initials: AC
authors.lastname: Dolphin
authors.forename: E
authors.initials: E
authors.lastname: Huston
authors.forename: R H
authors.initials: RH
authors.lastname: Scott
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D008024:Ligands; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology
chemical_list: D015220:Calcium Channels; D008024:Ligands; D018377:Neurotransmitter Agents; D019204:GTP-Binding Proteins; D002118:Calcium