Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives.
The sleep-wake effects of the proopiomelanocortin (POMC)-derived peptides, i.c.v. injected, are reported. Adrenocorticotropic hormone (ACTH, 1 microgram) induces an awakening effect, while its two derivatives, desacetyl-alpha-MSH (des-alpha-MSH, 1ng) and corticotropin-like intermediate lobe peptide (CLIP, 10 ng), are respectively able to increase slow wave sleep (SWS) and paradoxical sleep (PS); the hypnogenic effect of CLIP is also observed in hypophysectomized rats. Furthermore, two hypothalamic factors known to be involved in the control of POMC derivatives were also injected; MSH inhibiting Factor (MIF) does not influence the vigilance states, while Corticotropin Releasing Factor (CRF, 1 microgram) increases the waking state. Finally, some preliminary results, obtained with a restraint stress and suggesting a possible interrelation between stress, sleep and POMC derivatives, are discussed.
Chastrette
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Department of Experimental Medicine, INSERM U52, CNRS UA1195 Claude-Bernard University, Lyon, France.
Cespuglio
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Jouvet
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D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001414:Bacitracin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D053497:Corticotropin-Like Intermediate Lobe Peptide; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin / Q000494:pharmacology*; D051381:Rats; D012149:Restraint, Physical; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology; D000521:alpha-MSH / Q000031:analogs & derivatives / Q000494:pharmacology
D010446:Peptide Fragments; D001414:Bacitracin; D053497:Corticotropin-Like Intermediate Lobe Peptide; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; D002701:Chloramphenicol; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D009075:MSH Release-Inhibiting Hormone