title: Lens safety study with Picumast dihydrochloride--a double masked study using the Scheimpflug method.
abstract: A double-masked study was performed to investigate a possible side effect of the antiallergic substance Picumast dihydrochloride on lens transparency. 372 patients with Picumast dihydrochloride- or Ketotifen-treatment regularly underwent ophthalmologic examinations and Scheimpflug photography of the anterior eye segment. Results of slitlamp examinations as well as microdensitometric analyzes of the film negatives after one year treatment did not reveal any evidence that Picumast dihydrochloride compromised lens transparency in humans.
authors.affiliation: Department of Experimental Ophthalmology, University of Bonn, F.R.G.
authors.forename: O
authors.initials: O
authors.lastname: Hockwin
authors.forename: U
authors.initials: U
authors.lastname: Müller-Breitenkamp
authors.forename: H
authors.initials: H
authors.lastname: Laser
authors.forename: D
authors.initials: D
authors.lastname: Messinger
authors.forename: G
authors.initials: G
authors.lastname: Goder
authors.forename: U
authors.initials: U
authors.lastname: Meinel
mesh_terms: D001249:Asthma / Q000188:drug therapy; D002386:Cataract / Q000139:chemically induced*; D003374:Coumarins / Q000627:therapeutic use / Q000633:toxicity*; D003720:Densitometry; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007665:Ketotifen / Q000009:adverse effects; D007908:Lens, Crystalline / Q000187:drug effects*; D010781:Photography
chemical_list: D003374:Coumarins; D006634:Histamine H1 Antagonists; C013373:picumast; D007665:Ketotifen