Porcine gamma/delta T lymphocyte subsets differing in their propensity to home to lymphoid tissue.
Three types of T cell receptors (TcR) gamma/delta were identified in swine, all of which are disulfide-bonded cell surface heterodimers. The first, a 38/40-kDa molecule, is related to the TcR gamma/delta of sheep and cattle, and defines in swine a subset of CD4-CD8- T lymphocytes that is enriched in the circulating T lymphocyte pool. The other two receptors are private to swine. The second, a 37/40-kDa molecule, is expressed by the major subset of CD2-CD4-CD8- T lymphocytes that is neither enriched in nor excluded from lymphoid tissue. By contrast, the third type of TcR gamma/delta, a 40/46-kDa molecule, is found on CD2+CD4-CD8- T lymphocytes accumulating in lymphoid tissue. Thus, TcR gamma/delta T lymphocyte subsets differing in homing propensity are typified by the expression of distinct molecular forms of the TcR gamma/delta.
Saalmüller
A
A
Federal Research Centre for Virus Diseases of Animals, Tübingen.
Hirt
W
W
Reddehase
M J
MJ
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology / Q000502:physiology; D018801:CD2 Antigens; D015704:CD4 Antigens / Q000276:immunology / Q000502:physiology; D016827:CD8 Antigens; D002465:Cell Movement; D002469:Cell Separation; D004220:Disulfides; D004591:Electrophoresis, Polyacrylamide Gel; D005434:Flow Cytometry; D008221:Lymphoid Tissue / Q000166:cytology*; D008643:Mesentery / Q000166:cytology / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000502:physiology*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011971:Receptors, Immunologic / Q000276:immunology / Q000502:physiology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013552:Swine; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000502:physiology*
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D004220:Disulfides; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011971:Receptors, Immunologic