title: In vitro estimation of non-specific and specific amino acid decarboxylase activities in guinea-pigs treated with chlorpromazine.
abstract: 1. In vitro studies of non-specific histidine decarboxylase activity was low or absent in control guinea-pigs and unchanged 9 or 27 hr after chlorpromazine (CPZ) injection intraperitoneally. 2. However, specific histidine decarboxylase activity was found in the control tissues and was increased 9 hr but not 27 hr after CPZ injection.
authors.affiliation: Department of Biology, Faculty of Science and Natural Resources, University Kebangsaan Malaysia, Sabah.
authors.forename: B H
authors.initials: BH
authors.lastname: Ridzwan
authors.forename: N G
authors.initials: NG
authors.lastname: Waton
authors.forename: B O
authors.initials: BO
authors.lastname: Rozali
authors.forename: A M
authors.initials: AM
authors.lastname: Jais
authors.forename: A H
authors.initials: AH
authors.lastname: Maimun
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000378:metabolism*; D007082:Ileum / Q000187:drug effects / Q000201:enzymology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D013270:Stomach / Q000187:drug effects / Q000201:enzymology
chemical_list: D006632:Histamine; D006640:Histidine Decarboxylase; D002746:Chlorpromazine