Effect of tiacrilast, a mast cell mediator-release inhibitor, on murine experimental contact dermatitis.
The effect of tiacrilast, a mast cell mediator-release inhibitor, was studied in dinitrofluorobenzene-induced allergic and croton oil- or dimethyl sulfoxide-induced irritant murine contact dermatitis. At 1% concentration, the compound significantly reduced the ear swelling in both allergic and irritant dermatitis and preserved the mast cell architecture on histopathology. These findings suggest that mast cells participate in the elicitation of murine contact dermatitis.
Csatò
M
M
Department of Dermatology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Judák
R
R
Bozóky
B
B
Czarnetzki
B M
BM
D000818:Animals; D003436:Croton Oil / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004121:Dimethyl Sulfoxide / Q000009:adverse effects; D004139:Dinitrofluorobenzene / Q000009:adverse effects; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D051379:Mice; D011799:Quinazolines / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D011799:Quinazolines; C040252:tiacrilast; D003436:Croton Oil; D004139:Dinitrofluorobenzene; D004121:Dimethyl Sulfoxide