A multi-centre evaluation of two chlorhexidine-containing formulations for surgical hand disinfection.
Many experimental methods have been used to assess the efficacy of products intended for surgical hand disinfection. In this study, a modification of the Peterson glove juice method was used to compare two chlorhexidine-based surgical hand disinfectants, 'Hibiscrub' and an experimental formulation, F.6115. The study was performed by four independent laboratories and data merged for analysis. There was found to be no significant difference between the two formulations. The results illustrate that this modified Peterson glove juice method has the potential to form the basis of a standard method for testing surgical hand disinfectants which is both relevant to the practical situation and reproducible in different laboratories.
Holloway
P M
PM
ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire.
Platt
J H
JH
Reybrouck
G
G
Lilly
H A
HA
Mehtar
S
S
Drabu
Y
Y
D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D005260:Female; D006235:Hand Disinfection / Q000379:methods / Q000592:standards*; D006801:Humans; D008297:Male
C010882:chlorhexidine gluconate; D002710:Chlorhexidine