Beneficial response to megoestrol acetate in AIDS-related cachexia and a possible megoestrol withdrawal-associated syndrome?
A man with AIDS is described in whom a profound weight loss was converted into a weight gain by treatment with megoestrol acetate, a synthetic progesterone. His appetite improved and was accompanied by a feeling of improved well-being. Following abrupt discontinuation of the drug, there was a significant but transient depression of mood and appetite associated with loss of energy; it is suggested that this complex of symptoms might represent a megoestrol acetate withdrawal-associated syndrome.
Nathwani
D
D
Department of Infection & Tropical Medicine, Ruchill Hospital, Glasgow, Scotland.
Green
S T
ST
Heslop
J M
JM
Goldberg
D J
DJ
Kennedy
D H
DH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology; D003863:Depression / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008535:Megestrol / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome; D015431:Weight Loss
D008535:Megestrol