A cohort study of fat intake and risk of breast cancer.
Between 1982 and 1987, 519 newly incident, histologically confirmed cases of breast cancer were identified in a cohort of 56,837 women enrolled in the Canadian National Breast Screening Study. These women had completed a dietary questionnaire before the occurrence of their breast cancer, and this has been used to estimate their intake of dietary fat and several other nutrients. There is evidence of a positive association between breast cancer and total fat intake, with a relative risk of 1.35 (95% confidence interval, 1.00-1.82) per 77 g per day, and some evidence of a dose-response relationship (P = .052).
Howe
G R
GR
National Cancer Institute of Canada Epidemiology Unit, Faculty of Medicine, University of Toronto, ON.
Friedenreich
C M
CM
Jain
M
M
Miller
A B
AB
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology*; D015331:Cohort Studies; D004041:Dietary Fats / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D006801:Humans; D008875:Middle Aged; D012306:Risk
D004041:Dietary Fats