title: Rickets in Nigerian children: a consequence of calcium malnutrition.
abstract: Eleven Nigerian children with clinically and radiologically proven rickets were assessed biochemically. The children had low or low normal concentrations of total and corrected calcium, and elevated plasma alkaline phosphatase (ALP) activity, but normal plasma phosphate concentrations. Their serum 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentrations were not significantly different from those in controls, but the ratio of 1,25-(OH)2D to 25-OHD was significantly greater than that in controls. Parathyroid hormone (PTH) concentrations were greater in rachitic children, and there was a significant correlation between 1,25-(OH)2D and PTH concentrations. Osteocalcin concentrations in rachitic children were not significantly different from those in controls, but they were markedly elevated in the three patients with the highest 1,25-(OH)2D and PTH concentrations. One child, from whom a sample of bone (from a corrective osteotomy) was available for histological examination, showed markedly thickened osteoid seams, characteristic of rickets. All the rachitic children had a calcium intake of less than 150 mg daily. Treatment of these rachitic children with calcium gluconate (1 g/d) led to clinical, radiological, and biochemical healing of rickets. We conclude that rickets in Nigerian children is not due to vitamin D deficiency, but to a lack of calcium. This observation has implications regarding the pathogenesis, treatment, and prevention of rickets/osteomalacia in Nigeria and possibly other African and tropical countries.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Ile-Ife, Nigeria.
authors.forename: F
authors.initials: F
authors.lastname: Okonofua
authors.forename: D S
authors.initials: DS
authors.lastname: Gill
authors.forename: Z O
authors.initials: ZO
authors.lastname: Alabi
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: J L
authors.initials: JL
authors.lastname: Bell
authors.forename: P
authors.initials: P
authors.lastname: Dandona
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D002118:Calcium / Q000097:blood / Q000172:deficiency*; D002125:Calcium Gluconate / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D009549:Nigeria; D009994:Osmolar Concentration; D015675:Osteocalcin / Q000097:blood; D011859:Radiography; D012279:Rickets / Q000097:blood / Q000188:drug therapy / Q000209:etiology*
chemical_list: D006887:Hydroxycholecalciferols; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002125:Calcium Gluconate; D002118:Calcium