[Tumor markers--personal experience. Ha-ras P21 in neuroblastoma: a new marker associating to patient's prognosis].
Neuroblastoma is a disease with wide spectrum clinically For the evaluation of the biological specificity of this tumor, we examined the expression of Ha-ras p21. The Ha-ras p21 detected in tumor cells showed a statistically significant association with the non-progressed tumor at the diagnosis and the favourable outcome of the patients. The association of Ha-ras p21 with their clinical outcome was closer than those of N-myc amplification. However, the complementary analyses of both Ha-ras p21 and N-myc gene seemed to provide more precise informations relating the patient's care.
Tanaka
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T
Dept. of Pediatrics, National Kure Hospital, Japan.
D014408:Biomarkers, Tumor / Q000032:analysis*; D002675:Child, Preschool; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression; D016259:Genes, myc; D011905:Genes, ras; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics; D015689:Oncogene Protein p21(ras) / Q000032:analysis*; D016274:Oncogene Protein p55(v-myc) / Q000032:analysis; D011237:Predictive Value of Tests; D011379:Prognosis
D014408:Biomarkers, Tumor; D016274:Oncogene Protein p55(v-myc); D015689:Oncogene Protein p21(ras)