Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion.
Vaccinia-measles recombinant viruses were used to examine the contribution of the individual measles virus glycoproteins in fusion. Although vaccinia virus recombinants expressing either the haemagglutinin or fusion proteins did not induce fusion in the cell lines examined, a double recombinant expressing both measles virus glycoproteins gave extensive syncytia in cells of human and simian origin. No fusion was observed in mouse, hamster or chicken cells. The fusion induced by the double recombinant could be specifically inhibited with either anti-fusion or anti-haemagglutinin monoclonal antibodies.
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Immunovirologie Moléculaire et Cellulaire, UMR 30/CNRS, Faculté de Médicine Alexis Carrel, Lyon, France.
Malvoisin
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E
Buckland
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R
D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D004274:DNA, Recombinant; D005814:Genes, Viral; D015726:Giant Cells / Q000166:cytology*; D006367:HeLa Cells; D006389:Hemagglutinins, Viral / Q000378:metabolism*; D006801:Humans; D008459:Measles virus / Q000235:genetics / Q000502:physiology*; D011233:Precipitin Tests; D014616:Vaccinia virus / Q000235:genetics; D014760:Viral Fusion Proteins / Q000235:genetics / Q000378:metabolism*
D004274:DNA, Recombinant; D006389:Hemagglutinins, Viral; D014760:Viral Fusion Proteins