title: Immunization of owl monkeys with the ring-infected erythrocyte surface antigen of Plasmodium falciparum.
abstract: Aotus nancymai were immunized with the 4-mer, 8-mer, and 11-mer repeat peptides of the ring-infected erythrocyte surface antigen molecule of Plasmodium falciparum conjugated to diphtheria toxoid with muramyl dipeptide (MDP) as adjuvant. Immunization failed to induce protective immunity against the Uganda Palo Alto strain of P. falciparum as judged by maximum levels of parasitemia of immunized monkeys relative to those of controls. The fused polypeptide FPAg632, when combined with MDP, also failed to induce protective immunity. However, the maximum level of parasitemia and serologic response to the 11-mer peptide were inversely correlated. The safety of the use of MDP was evident.
authors.affiliation: Center for Infectious Diseases, Atlanta, Georgia.
authors.forename: W E
authors.initials: WE
authors.lastname: Collins
authors.forename: R F
authors.initials: RF
authors.lastname: Anders
authors.forename: T K
authors.initials: TK
authors.lastname: Ruebush
authors.forename: D J
authors.initials: DJ
authors.lastname: Kemp
authors.forename: G C
authors.initials: GC
authors.lastname: Woodrow
authors.forename: G H
authors.initials: GH
authors.lastname: Campbell
authors.forename: G V
authors.initials: GV
authors.lastname: Brown
authors.forename: D O
authors.initials: DO
authors.lastname: Irving
authors.forename: N
authors.initials: N
authors.lastname: Goss
authors.forename: V K
authors.initials: VK
authors.lastname: Filipski
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001029:Aotus trivirgatus; D005620:Freund's Adjuvant; D007114:Immunization; D008288:Malaria / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D014614:Vaccines, Synthetic
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D014614:Vaccines, Synthetic; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D005620:Freund's Adjuvant