title: Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms.
abstract: We analyzed the possibility of inherited predisposition to nondisjunction in a family with two cases of Down syndrome using restriction fragment length polymorphisms and cytogenetic heteromorphisms. In both patients the extra chromosome 21 was the result of a nondisjunction event at first meiotic division in the mother. Since both patients are maternally related, genetic predisposition cannot be excluded in this family.
authors.affiliation: Department of Biochemistry, University of Antwerp, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Stinissen
authors.forename: B
authors.initials: B
authors.lastname: Van Roy
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
authors.forename: H
authors.initials: H
authors.lastname: Backhovens
authors.forename: P
authors.initials: P
authors.lastname: Partoens
authors.forename: A
authors.initials: A
authors.lastname: Wehnert
authors.forename: H
authors.initials: H
authors.lastname: Verniers
authors.forename: J
authors.initials: J
authors.lastname: Dumon
authors.forename: A
authors.initials: A
authors.lastname: Vandenberghe
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
mesh_terms: D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008126:Lod Score; D008297:Male; D008540:Meiosis; D009630:Nondisjunction, Genetic; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004247:DNA