title: Inaccurate blood flow rate during rapid hemodialysis.
abstract: Simulated hemodialysis with isotonic saline was performed to compare the requested blood flow rate (BFR-r) with the actual blood flow rate (BFR-a) delivered during rapid, efficient hemodialysis. Four different blood pumps and blood lines from three different manufacturers were used for the studies. BFR-r was set on each blood pump, and a timed outflow specimen from the dialysis circuit was used to measure the BFR-a delivered. BFR-r values of 200, 350, and 500 mL/min were used; the arterial pressure was set at -50, -250, and -325 mm Hg. BFR was determined every hour for 5 hours. At an arterial pressure of -50 mm Hg, the BFR-a was slightly higher than the BFR-r, and this did not vary over the 5-hour study period. When the arterial pressure was -250 mm Hg, the initial BFR-a was 95% of the BFR-r; at the end of the 5-hour study, this had declined to an average of 87% of the BFR-r. The largest discrepancy between BFR-a and BFR-r was at an arterial pressure of -325 mm Hg; the initial actual values averaged only 90% of the requested, and by the end of the 5-hour study, this value had declined to a mean of 78% of the BFR-r. The use of whole blood with a hematocrit value of 33% and the addition of venous resistance did not significantly affect these results.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
authors.forename: D F
authors.initials: DF
authors.lastname: Schmidt
authors.forename: B J
authors.initials: BJ
authors.lastname: Schniepp
authors.forename: S B
authors.initials: SB
authors.lastname: Kurtz
authors.forename: J T
authors.initials: JT
authors.lastname: McCarthy
mesh_terms: D001783:Blood Flow Velocity; D006353:Heart-Assist Devices / Q000592:standards*; D006801:Humans; D007688:Kidneys, Artificial; D006435:Renal Dialysis / Q000295:instrumentation*