title: Comparison of functional and structural brain disturbances in Wilson's disease.
abstract: We assessed the functional and structural brain disturbances in Wilson's disease (WD) by evoked potentials (EPs) and magnetic resonance imaging (MRI). All the 25 neurologically symptomatic and 44% of the 16 asymptomatic patients, assessed by both EPs (n = 48) and imaging (n = 41), had at least 1 abnormality of either prolonged EP conduction times, imaging-outlined presence of cerebral lesions, or brain atrophy. Our findings indicate that EPs and MRI are sensitive techniques for the evaluation of brain involvement in WD.
authors.affiliation: 1st Department of Medicine, University of Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Grimm
authors.forename: L
authors.initials: L
authors.lastname: Prayer
authors.forename: W
authors.initials: W
authors.lastname: Oder
authors.forename: P
authors.initials: P
authors.lastname: Ferenci
authors.forename: C
authors.initials: C
authors.lastname: Madl
authors.forename: P
authors.initials: P
authors.lastname: Knoflach
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Imhof
authors.forename: A
authors.initials: A
authors.lastname: Gangl
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index