Induction of hepatic peroxisomes by a new, non-carboxylate-containing drug, bifonazole.
The acute effect of an antimycotic drug, bifonazole, on hepatic peroxisomes of rats was studied in comparison with that of clotrimazole, which has a similar structure. By feeding 0.5% bifonazole in the diet for 5 days, the activities of carnitine acyltransferase, carnitine palmitoyltransferase and the peroxisomal beta-oxidation system were increased by 30-, 3- and 7-fold, respectively, over the control. Under the same conditions, clotrimazole did not cause such changes. Electron microscopic observation showed that peroxisome proliferation had been induced by bifonazole treatment. Thus, a compound which does not contain a carboxylate moiety can induce peroxisomes in rodent liver.
Horie
S
S
Department of Clinical Biochemistry, Tokyo College of Pharmacy, Japan.
Fukumori
N
N
Suga
T
T
D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity*; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003022:Clotrimazole / Q000633:toxicity; D007093:Imidazoles / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009929:Organ Size; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D000935:Antifungal Agents; D007093:Imidazoles; D002374:Catalase; D002334:Carnitine O-Palmitoyltransferase; D002332:Carnitine O-Acetyltransferase; D003022:Clotrimazole; C036596:bifonazole