title: Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.
abstract: A series of four patients with pulmonary infiltrates, pleural effusions, hypoxemia, peripheral eosinophilia, and symptoms of dyspnea, fatigue, and weakness is reported. Lung tissue obtained in three patients revealed interstitial pneumonitis, small-to-medium-vessel mixed-cell vasculitis, and alveolar exudate of histiocytes and eosinophils. All patients reported ingestion of L-tryptophan-containing products at a time when an association between L-tryptophan and the eosinophilia-myalgia syndrome was established. This clinical pattern of pulmonary involvement may be part of the continuum of the eosinophilia-myalgia syndrome. The pathophysiology of this syndrome and the relationship with the ingestion of L-tryptophan-containing products have not yet been identified.
authors.affiliation: Kaiser Permanente Medical Center, Woodland Hills, Calif.
authors.forename: I J
authors.initials: IJ
authors.lastname: Strumpf
authors.forename: R D
authors.initials: RD
authors.lastname: Drucker
authors.forename: K H
authors.initials: KH
authors.lastname: Anders
authors.forename: S
authors.initials: S
authors.lastname: Cohen
authors.forename: O
authors.initials: O
authors.lastname: Fajolu
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced; D010996:Pleural Effusion / Q000139:chemically induced; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012651:Self Medication; D013577:Syndrome; D014364:Tryptophan / Q000009:adverse effects*
chemical_list: D014364:Tryptophan