title: Effect of Somatostatin on TSH levels in non-toxic sporadic goiter.
abstract: Somatostatin (SS-14; growth hormone-release inhibiting hormone) was infused into eight patients with non-toxic sporadic goiter and into eleven normal control subjects. Each patient was given 150 microgram(s) of somatostatin as an intravenous bolus and 350 microgram(s) by infusion over a period of 60 minutes. Somatostatin did not lower the basal TSH levels as compared to the pre-infusion levels in this type of goiter, but produced a decrease in the TSH response to TRH during and after the infusion.
authors.affiliation: Endocrine Service, Carlos Andrade Marin Hospital, Ecuadorian Social Security Institute, Quito.
authors.forename: J
authors.initials: J
authors.lastname: Varea
authors.forename: M
authors.initials: M
authors.lastname: Paredes
authors.forename: G
authors.initials: G
authors.lastname: Garces
authors.forename: C
authors.initials: C
authors.lastname: Ochoa
authors.forename: C
authors.initials: C
authors.lastname: Avila
authors.forename: M J
authors.initials: MJ
authors.lastname: Coloma
authors.forename: R
authors.initials: R
authors.lastname: Briones
authors.forename: A M
authors.initials: AM
authors.lastname: Comaru-Schally
authors.forename: A V
authors.initials: AV
authors.lastname: Schally
mesh_terms: D000328:Adult; D006042:Goiter / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D007700:Kinetics; D008875:Middle Aged; D012016:Reference Values; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
chemical_list: D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin