Localisation of a susceptibility locus for schizophrenia on chromosome 5.
"A considerable proportion of the variance in the liability to develop schizophrenia may be genetic, but segregation analysis, to establish a mode of transmission, has not produced a consistent result. One of these studies was carried out in Iceland and made use of the large family size and extensive genealogical information present in that country. Here we demonstrate genetic linkage of two DNA polymorphisms on the long arm of human chromosome 5 to schizophrenia in seven British and Icelandic families with multiple affected members. The results indicate the existence of a gene locus with a dominant schizophrenia-susceptibility allele. Inheritance of the allele in the families studied suggests that it may also predispose to psychiatric conditions such as schizophrenia spectrum disorders and a variety of other disorders. This report provides the first strong evidence for the involvement of a single gene in the causation of schizophrenia."
Owen
M
M
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff.
Craufurd
D
D
St Clair
D
D
D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology