Flow cytometric detection of tumor metastases during urologic surgery.
Flow cytometric studies were performed on peripheral blood obtained before, during, and subsequent to urologic surgery. The results suggest that 7 of 11 patients had a brief period during surgical manipulation when they had cells from the primary surgical site in the peripheral blood. Concentration of such cells was generally less than 10(2)/mL even during the intraoperative period. These findings suggest that perioperative tumor seeding is a real concern, and that flow cytometry can be used to study maneuvers to reduce its incidence.
Nusbaum
N J
NJ
Lee Streich Flow Cytometry Laboratory, Brooklyn, New York.
Kester
R R
RR
Mooppan
U M
UM
Kim
H
H
D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007432:Intraoperative Period; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control*; D009366:Neoplasm Seeding; D010865:Pilot Projects; D014571:Urologic Neoplasms / Q000601:surgery*
D004273:DNA, Neoplasm