Neurobehavioral changes produced by developmental exposure to benzodiazepines.
The results reported in this review show that prenatal and/or postnatal administration of benzodiazepines, at dose levels below those associated with overt signs of neurotoxicity, produces both short- and long-term alterations in rats. Most of these behavioral changes are characterized by altered activity patterns and emotional/motivational responsiveness to environmental challenges.
De Salvia
M A
MA
Institute of Pharmacology, University of Bari, Italy.
Cagiano
R
R
Lacomba
C
C
Cuomo
V
V
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines