The mouse erythrocyte binding receptor is expressed on human keratinocytes.
Immunocytes and different types of epidermal cells share cell surface antigen characteristics e.g. keratinocytes react specifically with the Leu 11 (CD16) monoclonal antibody and they express MHC class II and OKM5 (CD36) antigens after gamma-interferon stimulation. The present study provides evidence that a subpopulation of human keratinocytes most probably at a certain stage of differentiation, possesses the mouse erythrocyte binding receptor the marker of a human B lymphocyte subset. This finding is a further evidence for the relationship between the epidermis and the immune system.
Dobozy
A
A
Department of Dermatology, Albert Szent-Györgyi Medical University, Szeged.
Hunyadi
J
J
Bozoky
B
B
Monostori
E
E
Andó
I
I
Kenderessy
A S
AS
Tiba
A
A
D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D018801:CD2 Antigens; D002454:Cell Differentiation / Q000235:genetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D011971:Receptors, Immunologic / Q000235:genetics*; D012397:Rosette Formation
D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D011971:Receptors, Immunologic; C056705:mouse erythrocyte receptor