title: Isotonic high-sodium oral rehydration solution for increasing sodium absorption in patients with short-bowel syndrome.
abstract: We compared the effect of a standard oral rehydration solution and a high-sodium polymeric-glucose solution on sodium absorption in short-bowel syndrome. Six patients with high jejunostomy were tested in a random order with the standard solution or a solution containing maltodextrins (18 g Glucidex 12/L) enriched with 2.5 g NaCl/L. Solutions were administered via a nasogastric tube at a rate of 2 mL/min. Jejunal effluent was collected during an 8-h period. The net 8-h fluid absorption was not significantly different in the two periods. Glucose absorption was greater than 90% of the administered amount for both solutions. Net sodium absorption was greater for the maltodextrin solution than for the standard solution (56 +/- 12 vs 24 +/- 20 mmol, P less than 0.05). We conclude that replacement of glucose with maltodextrins and addition of sodium in the standard oral rehydration solution results in improved sodium absorption in short-bowel syndrome.
authors.affiliation: Service d'Hépato-Gastroentérologie, Hôpital Rothschild, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: J
authors.initials: J
authors.lastname: Cosnes
authors.forename: F
authors.initials: F
authors.lastname: Verwaerde
authors.forename: H
authors.initials: H
authors.lastname: Dupas
authors.forename: P
authors.initials: P
authors.lastname: Lamy
authors.forename: J P
authors.initials: JP
authors.lastname: Gendre
authors.forename: Y
authors.initials: Y
authors.lastname: Le Quintrec
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005440:Fluid Therapy; D005947:Glucose; D006801:Humans; D007552:Isotonic Solutions; D007582:Jejunostomy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011134:Polysaccharides; D015532:Rehydration Solutions; D012778:Short Bowel Syndrome / Q000628:therapy*; D012964:Sodium / Q000378:metabolism*
chemical_list: D007552:Isotonic Solutions; D011134:Polysaccharides; D015532:Rehydration Solutions; C008315:maltodextrin; D012964:Sodium; D005947:Glucose