Amino acids and peptides. XIV. Laminin related peptides and their inhibitory effect on experimental metastasis formation.
Inhibitory effects of synthetic laminin related peptides on experimental metastasis formation in mice were examined. Of the synthetic peptides, YIGSRG-[amino-poly(ethylene glycol)] hybrid exhibited the most potent inhibitory effect on the metastasis of B16 melanoma BL6.
Kawasaki
K
K
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Namikawa
M
M
Murakami
T
T
Mizuta
T
T
Iwai
Y
Y
Hama
T
T
Mayumi
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents; D002460:Cell Line; D007797:Laminin / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007797:Laminin; D010455:Peptides