A new heparin binding protein regulated by retinoic acid from chick embryo.
A 19 KDa heparin binding protein was previously purified from chicken embryos. Essentially localized within basement membranes in early embryonic tissues, this protein is very rich in basic and cystein residues. Its N-terminal fragment is similar to corresponding fragment of two other proteins expressed during embryogenesis and postnatal period. Its synthesis and secretion are induced by retinoic acid in chicken myoblasts and fibroblasts. This new retinoic acid induced heparin binding protein (RI-HB) does stimulate neurite outgrowth and proliferation on PC12 cells. These results suggest that retinoic acid could regulate some aspect of differentiation and development by inducing the synthesis of a new family of growth and neurotrophic factors.
Raulais
D
D
Unite de Recherches Gerontologiques, Inserm U 118, CNRS Unite Affilee 630 Paris, France.
Lagente-Chevallier
O
O
Guettet
C
C
Duprez
D
D
Courtois
Y
Y
Vigny
M
M
D000310:Adrenal Gland Neoplasms; D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D015153:Blotting, Western; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D002642:Chick Embryo; D005326:Fetal Proteins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007525:Isoelectric Focusing; D008969:Molecular Sequence Data; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D010673:Pheochromocytoma; D012689:Sequence Homology, Nucleic Acid; D014212:Tretinoin / Q000494:pharmacology*
D002352:Carrier Proteins; D005326:Fetal Proteins; D014212:Tretinoin