DNA sequence polymorphisms in Alu repeats.
We have developed an efficient method for detection of sequence differences in genomic DNA based on a new principle (M. Orita et al., 1989, Genomics 5: 874-879). Using this method, we show here that approximately half the Alu repeats interspersed in the human genome are significantly polymorphic. Analysis of Alu repeat polymorphism should be useful in construction of a high-resolution map and also in identifying genotypes of individuals for clinical and other purposes because the repeats are ubiquitous and the technique for their detection is simple.
Orita
M
M
Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.
Sekiya
T
T
Hayashi
K
K
D001483:Base Sequence; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid