Pathogenesis of hypertrophic cardiomyopathy: another viewpoint.
A genetically determined error in the handling of catecholamines by the developing heart has been speculated to cause hypertrophic cardiomyopathy. A critical appraisal of the published literature reveals that there is little actual experimental or clinical evidence favouring the role of catecholamines in the pathogenesis of hypertrophic cardiomyopathy. Other factors seem to be more important. An abnormality of myocardial growth, either induced by excessive growth promoting substance, or a genetically determined abnormality in myocardial responses to normal growth factors during life (but not in the fetal handling of catecholamines) is likely to be responsible for hypertrophic cardiomyopathy.
Kothari
S S
SS
Institute of Cardiology, New Civil Hospital, Ahmedabad, India.
D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000235:genetics*; D002395:Catecholamines / Q000502:physiology*; D005318:Fetal Heart / Q000378:metabolism; D006133:Growth Substances / Q000502:physiology; D006321:Heart / Q000254:growth & development; D006801:Humans
D002395:Catecholamines; D006133:Growth Substances