Lack of association between DQ A and DX A polymorphisms with rheumatoid arthritis and Felty's syndrome.
DQ A and DX A RFLPs were studied in DR4-positive rheumatoid arthritis, Felty's syndrome, and in DR4-positive control subjects, and in the light of the previously documented association between Felty's syndrome and the DQ B 3.1 allele (3b RFLP). In these DR4-positive subjects there were no preferential associations between DQ A or DX A polymorphisms and rheumatoid arthritis or Felty's syndrome and no evidence for unusual DQ A-B haplotypic associations in Felty's or rheumatoid subjects.
Bate
A S
AS
Rheumatic Diseases Centre, Hope Hospital, Salford.
Ollier
W
W
Grennan
D M
DM
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005258:Felty Syndrome / Q000276:immunology*; D014644:Genetic Variation; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000032:analysis; D006239:Haplotypes; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D015804:HLA-DR4 Antigen; C040626:HLA-Dx antigen