Minimal Rev-response element for type 1 human immunodeficiency virus.
Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.
Huang
X J
XJ
Department of Pathology, University of California, San Francisco 94143-0506.
Hope
T J
TJ
Bond
B L
BL
McDonald
D
D
Grahl
K
K
Parslow
T G
TG
D001483:Base Sequence; D001665:Binding Sites; D015752:Genes, env; D015497:HIV-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000737:chemistry; D012091:Repetitive Sequences, Nucleic Acid
D012333:RNA, Messenger