Hypervariable regions of DNA for parentage testing and individual identification.
Four kinds of DNA probes that recognize hypervariable regions (HVR) were studied for parentage testing and individual identification. Allele frequencies and their confidence intervals among unrelated Japanese individuals were obtained. Codominant segregation of the polymorphism was confirmed in family studies. Two a priori probabilities were calculated for each HVR locus: the exclusion probabilities for an alleged father/mother/child trio and for an alleged parent/child duo, and the probabilities of matching of genotypes of two unrelated individuals or two siblings. The ease of availability of the probes and their highly discriminating polymorphic patterns mean they could be very useful for forensic purposes.
Yokoi
T
T
Department of Forensic Medicine, Tohoku University School of Medicine, Sendai, Japan.
Nata
M
M
Odaira
T
T
Sagisaka
K
K
D000483:Alleles; D002648:Child; D015342:DNA Probes; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D010334:Paternity; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*
D015342:DNA Probes; D005819:Genetic Markers