title: Multiple cranial nerve deficits after ethylene glycol poisoning.
abstract: We report the cases of two patients who developed cranial nerve palsies after drinking ethylene glycol. A 33-year-old man developed multiple cranial nerve deficits nine days after the ingestion of ethylene glycol in a suicide attempt. Clinical findings included profound bilateral cranial nerve VII palsies and severe dysfunction of cranial nerves IX and X. The neuropathy occurred despite treatment with hemodialysis. The dysphagia completely cleared within two weeks, but at six months a severe bilateral cranial nerve VII dysfunction persisted. A 22-year-old man undergoing hemodialysis for ethylene glycol-induced renal failure developed bilateral cranial nerve VII dysfunction 14 days after ingestion. At a three-month follow-up, the patient demonstrated only moderate functional recovery. The etiology of the cranial nerve deficits is unknown but may be related to oxalate crystal deposition of ethylene glycol-induced pyridoxine dysfunction.
authors.affiliation: Department of Emergency Medicine (Division of Toxicology), Mercy Catholic Medical Center, Philadelphia, Pennsylvania.
authors.forename: L
authors.initials: L
authors.lastname: Spillane
authors.forename: J R
authors.initials: JR
authors.lastname: Roberts
authors.forename: A E
authors.initials: AE
authors.lastname: Meyer
mesh_terms: D000328:Adult; D003389:Cranial Nerve Diseases / Q000139:chemically induced*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000506:poisoning*; D005158:Facial Paralysis / Q000139:chemically induced; D005930:Glossopharyngeal Nerve; D006801:Humans; D008297:Male; D010243:Paralysis / Q000139:chemically induced; D014630:Vagus Nerve
chemical_list: D005026:Ethylene Glycols; D019855:Ethylene Glycol