title: The measurement of internal pressure of ampoules and its application to commercial products.
abstract: This paper reports a method for determining the internal pressures of ampoules, from the head space and the change in volume on opening, as measured by displacement of water. Using this method, internal pressures of commercial ampoules were shown to be lower than atmospheric pressure. For example, the ratio of internal pressure to atmospheric pressure in a commercial ampoule of 5 mL distilled water was 0.884 at room temperature (23 degrees C).
authors.affiliation: Department of Hospital Pharmacy, Tottori University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tatsuhara
authors.forename: F
authors.initials: F
authors.lastname: Tabuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
mesh_terms: D001274:Atmospheric Pressure; D004340:Drug Contamination; D004349:Drug Packaging; D004867:Equipment Design; D055585:Physical Phenomena; D010825:Physics