title: Unprepared human colon does not discriminate between solids and liquids.
abstract: In five healthy male volunteers, we compared solid and liquid transit though the unprepared colon. 99mTc-diethylenetriaminepentaacetic acid in 10 ml saline was injected into the cecum through an orocecal tube at 1 ml/min immediately after a methacrylate-coated medication capsule was seen to deliver 111In-labeled Amberlite IR-120PLUS pellets (avg diam, 1.0 mm) into the cecum. Segmental transits through the ascending, transverse, descending, and rectosigmoid regions were determined using a dual gamma camera system and a variable region of interest program. There was no difference between solid [half time, 247 +/- 60 (SE) min] and liquid (312 +/- 88 min) emptying from the ascending colon. Colonic transit of solids and liquids was further compared by regional counts and stool outputs at 12 and 24 h. There were no significant differences between solids and liquids (P greater than 0.05). Our data suggest that transit through the unprepared human colon is not different for solids and small volumes of liquids, when these are delivered together to the ascending colon.
authors.affiliation: Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: M
authors.initials: M
authors.lastname: Proano
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: S F
authors.initials: SF
authors.lastname: Phillips
authors.forename: G M
authors.initials: GM
authors.lastname: Thomforde
authors.forename: M L
authors.initials: ML
authors.lastname: Brown
authors.forename: R L
authors.initials: RL
authors.lastname: Tucker
mesh_terms: D000328:Adult; D003106:Colon / Q000000981:diagnostic imaging / Q000502:physiology*; D004032:Diet; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D009130:Muscle, Smooth / Q000000981:diagnostic imaging / Q000502:physiology; D011877:Radionuclide Imaging; D012016:Reference Values; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D016284:Technetium Tc 99m Pentetate