title: Effect of adrenal hypotension on elicited secretory activity in anesthetized dogs.
abstract: The objective of this study was to determine whether three- to fourfold increases in adrenal medullary blood flow (MQ), observed during catecholamine secretion induced by splanchnic nerve stimulation (NS), are necessary for a maximal secretory response. Eight pentobarbital-anesthetized adult male mongrel dogs (25-35 kg) were subjected to two episodes of NS-induced catecholamine secretion. To limit increases in MQ, one NS (20 Hz, 8 V, 1.5 ms) was performed under control conditions, the other was after reduction of adrenal perfusion pressure (PP). PP was 124.8 +/- 6.0 at control and was reduced to 23.0 +/- 1.0 mmHg by inflation of an aortic occluder located 3 in. above the adrenals. NS under control conditions increased ipsilateral MQ (measured using radiolabeled microspheres) from 181 +/- 39 to 1,336 +/- 199 ml.min-1.100 g-1 and adrenal epinephrine secretion from 184 +/- 128 to 11,445 +/- 5,216 ng.min-1.g medulla-1. Contralateral MQ and cortical blood flow were unaffected by NS. Reduction of PP decreased MQ to 32 +/- 6 ml.min-1.100 g-1 and adrenal cortical blood flow from 251 +/- 23 to 25 +/- 6 ml.min-1.100 g-1.PP reduction had no effect on either corticosteroid secretion or unstimulated epinephrine secretion. NS at reduced PP increased ipsilateral MQ to 146 +/- 27 ml.min-1.100 g-1 and epinephrine secretion to 13,935 +/- 5,175 ng.min-1.g medulla-1. These data indicate that epinephrine secretion is not altered when MQ is limited by reduction of PP and suggest that, at normal PP, increases in MQ during catecholamine secretion are not necessary for a maximal secretory response.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
authors.forename: M J
authors.initials: MJ
authors.lastname: Breslow
authors.forename: J R
authors.initials: JR
authors.lastname: Tobin
authors.forename: K L
authors.initials: KL
authors.lastname: Kubos
authors.forename: H
authors.initials: H
authors.lastname: Raff
authors.forename: R J
authors.initials: RJ
authors.lastname: Traystman
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000311:Adrenal Glands / Q000098:blood supply / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000097:blood*; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D007022:Hypotension / Q000503:physiopathology*; D010477:Perfusion; D012039:Regional Blood Flow; D013153:Splanchnic Nerves / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D004837:Epinephrine