Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations.
We have investigated the structure of mu-conotoxin GIIIA by 2D-NMR methods. The assignment of 1H NMR spectra and a quantitative analysis of NOE and J-coupling data are presented. These results were used for the calculation of secondary structure elements of mu-conotoxin GIIIA. Distance geometry calculations were carried out to define the global folding of the peptide.
Ott
K H
KH
Institut für Biophysikalische Chemie, J.W. Goethe Universität, Frankfurt am Main, Germany.
Becker
S
S
Gordon
R D
RD
Rüterjans
H
H
D000595:Amino Acid Sequence; D000818:Animals; D003196:Computer Graphics; D020916:Conotoxins; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011487:Protein Conformation; D012908:Snails; D012996:Solutions
D020916:Conotoxins; D009498:Neurotoxins; D010456:Peptides, Cyclic; D012996:Solutions; C046101:conotoxin GIII