Selective stimulation of carboxylesterases metabolizing charged steroid esters by hydrocortisone.
We observed a remarkable augmentation in the rate of hydrolytic breakdown of HCHS following exposure to corticosteroid therapy. This underscores the need for a careful reappraisal of its dosage in long term therapy. In such an event the uncharged ester may be the preferred drug of choice.
Kaur
S
S
Jawaharlal Nehru Laboratories of Molecular Biology, Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Khanna
P
P
Parmar
S S
SS
Ali
B
B
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
C021650:hydrocortisone acetate; D002265:Carboxylic Ester Hydrolases; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone