title: Nuclear antigen with a molecular weight of 48,000 associated with malignant transformation.
abstract: 1. Analysis of immunoblots of one- and two-dimensional electropherograms of non-histone proteins from Kirkman-Robbins hepatoma, Morris hepatoma 7777, regenerating liver and normal liver demonstrated the presence of elevated level of nuclear antigen with mol. wt of 48,000 and pI of 5.4 in tumour cells. 2. Small amounts only were detected in proliferating and quiescent cells suggesting that different expression of this component may reflect biochemical events related to malignant transformation rather than to general cell activation.
authors.affiliation: Department of Cytobiochemistry, University of Lodz, Poland.
authors.forename: W M
authors.initials: WM
authors.lastname: Krajewska
authors.forename: M
authors.initials: M
authors.lastname: Marszałek
authors.forename: M
authors.initials: M
authors.lastname: Gaczyński
authors.forename: L
authors.initials: L
authors.lastname: Kłyszejko-Stefanowicz
mesh_terms: D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000737:chemistry*; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D007526:Isoelectric Point; D008099:Liver / Q000737:chemistry / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000737:chemistry; D008115:Liver Regeneration; D008297:Male; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D051381:Rats
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins