Effect of omeprazole on serum gastrin levels: influence of age and sex.
Serum gastrin levels were determined in 120 consecutive patients (43 females, 77 males) with peptic disease 24 h post dose after 4 weeks continuous omeprazole (40 mg daily) treatment. Serum gastrin levels were elevated in 33 (28%) but exceeded the twice normal range in only 6 patients (5%). Age and sex did not influence the magnitude of gastrin levels. Gastrin increments induced by omeprazole compared to pretreatment with H2-blockers in 60 cases were similar in both males (42 +/- 10 pg/ml) and females (44 +/- 9 pg/ml). It is concluded that the magnitude of gastrin increases observed during omeprazole therapy are small and independent of age and sex.
Koop
H
H
Department of Medicine, Philipps-University, Marburg, FRG.
Naumann-Koch
C
C
Arnold
R
R
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004942:Esophagitis, Peptic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005755:Gastrins / Q000097:blood*; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy*; D012737:Sex Factors
D005755:Gastrins; D006635:Histamine H2 Antagonists; D009853:Omeprazole