The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.
The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.
Aksenova
M V
MV
All-Union Research Center for Mental Health, USSR Academy of Medical Sciences, Moscow.
Burbaeva
G S
GS
Kandror
K V
KV
Kapkov
D V
DV
Stepanov
A S
AS
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D015153:Blotting, Western; D047388:Casein Kinases; D002540:Cerebral Cortex / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008875:Middle Aged; D010766:Phosphorylation; D011494:Protein Kinases / Q000032:analysis*; D012559:Schizophrenia / Q000201:enzymology*
D011494:Protein Kinases; D047388:Casein Kinases