Mutagenicity of 3-nitrodibenzofuran and 3-aminodibenzofuran.
Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzo[a]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and was 10 times stronger in TA98 and about 5 times stronger in TA100 than that of benzo[a]pyrene.
Uno
Y
Y
Chemistry and Physics Division, National Institute for Environmental Studies, Ibaraki, Japan.
Matsushita
H
H
Uehiro
T
T
Yasuhara
A
A
Morita
M
M
D001572:Benzofurans / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D001572:Benzofurans; D009153:Mutagens; C067510:3-aminodibenzofuran; C067509:3-nitrodibenzofuran; C023614:dibenzofuran