[Serum deoxythymidine kinase activity in adult T-cell leukemia].
Serum deoxythymidine kinase activities (s-TK) of the patients with adult T-cell leukemia (ATL), carriers and healthy persons were measured, using a recently developed TK assay with 125I-iodo-deoxyuridine as a substrate. The mean s-TK values were 3.3 +/- 2.7 U/l (n = 21) in normal subjects (HTLV-1(-)), 4.7 +/- 5.0 U/l (n = 35) in carriers, 9.8 U/l (n = 3) in smoldering ATL and 26.7 U/l (n = 6) in chronic ATL. In the patients with acute ATL, the mean s-TK values before and after chemotherapy were 80.9 U/l (n = 2) and 11.6 U/l (n = 4), respectively. In the follow-up studies of the patients with acute ATL, the changes of s-TK levels revealed earlier than those of serum LDH levels. It is suggested that s-TK activity is more useful than LDH as a parameter of monitoring treatment in ATL.
Kagimoto
T
T
Dept. of 2nd Internal Medicine, Kumamoto University Medical School.
Oda
T
T
Nakakuma
H
H
Kawaguchi
T
T
Hidaka
M
M
Horikawa
K
K
Matsuzaki
H
H
Takatsuki
K
K
D014408:Biomarkers, Tumor / Q000097:blood*; D002353:Carrier State / Q000097:blood / Q000175:diagnosis; D004796:Clinical Enzyme Tests / Q000379:methods; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000175:diagnosis*; D007958:Leukocyte Count; D013937:Thymidine Kinase / Q000097:blood*
D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D013937:Thymidine Kinase