Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody.
Treatment of rats with a specific Fab' fragment of anti-nerve growth factor (NGF)-antibody (anti-NGF, 12, 120 and 400 micrograms/4 weeks, i.c.v.) impaired their learning ability. The distance of swimming of anti-NGF-treated rats in a water maze was shortened more slowly by training than that of control rats. Anti-NGF treatment altered the staining of nuclei of cells in the hippocampus, parietal cortex and dentate gyrus with hematoxylin. It is suggested that the anti-NGF-induced amnesia could be due to change in nuclear morphology.
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Ogawa
S
S
Ishimaru
H
H
Kameyama
T
T
Fukuta
T
T
Takeuchi
R
R
Hayashi
K
K
D000818:Animals; D006624:Hippocampus / Q000473:pathology; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000503:physiopathology*; D009043:Motor Activity; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors
D007140:Immunoglobulin Fab Fragments; D009414:Nerve Growth Factors