title: Ciprofloxacin does not impair the elimination of diazepam in humans.
abstract: The pharmacokinetics of a single iv dose of 10 mg diazepam and the renal excretion of its metabolites resulting from N-demethylation and C-3-hydroxylation were investigated in 10 healthy volunteers when diazepam was administered alone and on day 3 of administration of the fluoroquinolone ciprofloxacin (500 mg twice per day). No significant changes in the diazepam half-life, its volume of distribution, the total body clearance, or the renal clearance were observed. In addition, the renal excretion of the metabolites desmethyldiazepam, 3-hydroxydiazepam (temazepam), and 3-hydroxydesmethyldiazepam (oxazepam) were not altered by ciprofloxacin co-medication. These data demonstrate that in a 500 mg twice per day oral dosage, ciprofloxacin does not influence the metabolic clearance of diazepam in young healthy volunteers.
authors.affiliation: Department of Pulmonary Diseases, Foundation of Deventer Hospitals, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Wijnands
authors.forename: J F
authors.initials: JF
authors.lastname: Trooster
authors.forename: P C
authors.initials: PC
authors.lastname: Teunissen
authors.forename: H A
authors.initials: HA
authors.lastname: Cats
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
mesh_terms: D000328:Adult; D002939:Ciprofloxacin / Q000009:adverse effects / Q000494:pharmacology*; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000097:blood
chemical_list: D002939:Ciprofloxacin; D003708:Nordazepam; D003975:Diazepam