The role of serotonin in sexual dysfunction: fluoxetine-associated orgasm dysfunction.
Iatrogenic sexual dysfunction has been associated with many pharmacologic agents. The authors report 6 cases of orgasm dysfunction associated with the use of fluorxetine in 77 depressed outpatients. Fluoxetine is a novel antidepressant known to block the reuptake of serotonin with little effect on other neurotransmitter systems. Because fluoxetine has a specific mechanism of action, it serves as a useful model to hypothesize about potential mechanisms of drug-induced sexual dysfunction. The possible effects of serotonin on central, spinal, and peripheral anatomical areas are discussed in relation to drug-induced sexual dysfunction.
Zajecka
J
J
Rush-Presbyterian-St. Luke's Medical Center, Department of Psychiatry, Chicago, Ill 60612.
Fawcett
J
J
Schaff
M
M
Jeffriess
H
H
Guy
C
C
D000328:Adult; D000553:Ambulatory Care; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D009948:Orgasm / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000503:physiopathology
D012702:Serotonin Antagonists; D005473:Fluoxetine; D012701:Serotonin