title: Conservative treatment of ectopic pregnancy with local injection of hyperosmolar glucose solution or prostaglandin-F2 alpha: a prospective randomised study.
abstract: In a prospective randomised study, 31 patients with an unruptured tubal pregnancy were treated either with local and systemic prostaglandins or with local instillation of a hyperosmolar glucose solution. Prostaglandin therapy was successful in 13 of 15 patients and glucose therapy in 16 of 16. 9 women treated with prostaglandins had cramping abdominal pains postoperatively. No side-effects were noted in those treated with glucose. At subsequent hysterosalpingography 5 of 6 patients treated with prostaglandins and 7 of 8 treated with glucose had normal tubal configuration and patency. 3 patients treated with glucose later had a normal intrauterine pregnancy, demonstrably through the affected tube in 1 case. These results suggest that local instillation of hyperosmolar glucose solution is an option in the laparoscopic management of unruptured tubal pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, University of Graz, Austria.
authors.forename: P F
authors.initials: PF
authors.lastname: Lang
authors.forename: P A
authors.initials: PA
authors.lastname: Weiss
authors.forename: H O
authors.initials: HO
authors.lastname: Mayer
authors.forename: J G
authors.initials: JG
authors.lastname: Haas
authors.forename: W
authors.initials: W
authors.lastname: Hönigl
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood / Q000652:urine; D015237:Dinoprost / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009994:Osmolar Concentration; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
chemical_list: D006063:Chorionic Gonadotropin; D015237:Dinoprost; D005947:Glucose