title: Tubulosine: an antitumor constituent of Pogonopus speciosus.
abstract: From the antitumor-bioactive sap of Pogonopus speciosus, tubulosine [1] was isolated, by activity-directed fractionation using the brine shrimp lethality test, as the major antitumor constituent. 1H-nmr assignments, obtained from HETCOR and COSY, and X-ray crystallographic results are reported for the first time. Psychotrine [2] was also isolated, and its spectral data are also reported.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
authors.forename: W W
authors.initials: WW
authors.lastname: Ma
authors.forename: J E
authors.initials: JE
authors.lastname: Anderson
authors.forename: A T
authors.initials: AT
authors.lastname: McKenzie
authors.forename: S R
authors.initials: SR
authors.lastname: Byrn
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
authors.forename: M S
authors.initials: MS
authors.lastname: Hudson
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004640:Emetine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D007486:Ipecac / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C009805:tubulosine; D007486:Ipecac; D004640:Emetine