[The central nervous system and inflammation: the role of opioid peptides].
Inhibition of human granulocyte aggregation was observed in the presence of morphine in a naloxone stereoselective way, while the opioid peptides were ineffective. In comparative studies Ca(+)+ (A23187) and dynorphin 1-9, per se, induced stimulation of arachidonic acid metabolites from granulocytes. In this regard dynorphin 1-9 may function as a mediator between the central nervous system and the inflammation.
Mazzone
A
A
Dipartimento di Medicina Interna, Università di Pavia.
Ricevuti
G
G
Fioravanti
A
A
Pasotti
D
D
Vitto
A R
AR
Mirto
L
L
Vignali
C
C
Avato
F
F
Notario
A
A
D001095:Arachidonic Acids / Q000378:metabolism; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology*; D004399:Dynorphins / Q000494:pharmacology; D004723:Endorphins / Q000502:physiology*; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D007975:Leukotriene B4 / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D013931:Thromboxanes / Q000378:metabolism
D001095:Arachidonic Acids; D004723:Endorphins; D010446:Peptide Fragments; D013931:Thromboxanes; D007975:Leukotriene B4; D009270:Naloxone; D004399:Dynorphins; D009020:Morphine; C040238:dynorphin A (1-9)