Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.
Sinha
A A
AA
Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.
Bell
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RB
Steinman
L
L
McDevitt
H O
HO
D000483:Alleles; D001483:Base Sequence; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D015345:Oligonucleotide Probes
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen; D006684:HLA-DR Antigens; D015345:Oligonucleotide Probes