Median infective dose of Treponema pallidum determined in a highly susceptible guinea pig strain.
The median infective dose of Treponema pallidum subsp. pallidum and the production of immunity to reinfection in C4D guinea pigs have been determined with 10(1) to 10(6) organisms per infective dose. The mean infective dose is 10(2) organisms, and immunity--in those animals that demonstrated lesions--developed after 4.5 months postinfection.
Wicher
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Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Wicher
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D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D013601:T-Lymphocytes / Q000276:immunology; D014210:Treponema pallidum / Q000276:immunology / Q000472:pathogenicity*
D000907:Antibodies, Bacterial