title: N-isopropyl-p-[123I]iodoamphetamine SPECT in MELAS syndrome: comparison with CT and MR imaging.
abstract: Regional cerebral perfusion was studied in three patients with the mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome, using single photon emission computed tomography (SPECT) with N-isopropyl-p-[123I]iodoamphetamine (IMP). Accumulation of the tracer was relatively decreased in the parietooccipital regions and also in the frontotemporal regions after stroke-like episodes. However, quantitative regional cerebral blood flow (rCBF) measurement showed that rCBF was relatively well preserved even at these sites, and a hyperemic state was observed at the sites of normal accumulation. IMP SPECT may be useful in the diagnosis and assessment of the progress of the MELAS syndrome.
authors.affiliation: Department of Radiology, University of Tsukuba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Akisada
mesh_terms: D000140:Acidosis, Lactic / Q000000981:diagnostic imaging* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000662:Amphetamines; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008297:Male; D008931:Mitochondria, Muscle / Q000000981:diagnostic imaging; D009135:Muscular Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine