Clinical significance of multiple drug resistance in human cancers.
This review summarizes the basic aspects of multidrug resistance (MDR). We first propose a brief reappraisal of the occurrence of MDR encoded P-glycoprotein, (P-g-P) in various normal and tumor tissues. We then present a series of studies undertaken to estimate the MDR1 gene expression or the presence of P-g-P in various human cancers. Finally, we conclude on the potential use of P-g-P measurements in some cancers as a useful if not powerful means of reversing clinical multidrug resistance.
Bénard
J
J
Laboratory of Molecular and Clinical Pharmacology, Institut Gustave Roussy, Villejuif, France.
Bourhis
J
J
Riou
G
G
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004351:Drug Resistance / Q000235:genetics*; D015870:Gene Expression; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins; D005982:Glutathione Transferase