Sapurimycin, new antitumor antibiotic produced by Streptomyces. Structure determination.
The structure of a new anthra-gamma-pyrone antitumor antibiotic sapurimycin was determined by the spectral studies of its methyl ester. Sapurimycin has the same anthra-gamma-pyrone skeleton as pluramycin, but is distinctly different because of the absence of sugars on the D ring and possessing a carboxylmethyl group on C-5.
Uosaki
Y
Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Yasuzawa
T
T
Hara
M
M
Saitoh
Y
Y
Sano
H
H
D000880:Anthraquinones / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D004952:Esters; C067706:sapurimycin