Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha.
An 8-year-old boy with subacute sclerosing panencephalitis (SSPE) was treated with 1.0 to 3.0 x 10(6) IU human interferon alpha (IFN) by the intrathecal route weekly or fortnightly. Pronounced improvement of clinical and electroencephalographic findings were observed in a dose-dependent manner. Our patient raises hope that IFN can induce sustained remission in patients with SSPE.
Miyazaki
M
M
Department of Pediatrics, University of Tokushima, School of Medicine, Japan.
Hashimoto
T
T
Fujino
K
K
Goda
T
T
Tayama
M
M
Kuroda
Y
Y
D002648:Child; D004569:Electroencephalography; D006801:Humans; D007278:Injections, Spinal; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000503:physiopathology / Q000628:therapy*
D007370:Interferon Type I