title: Effect of relaxin on mammary development in ovariectomized pregnant gilts.
abstract: The role of relaxin in mammary development was studied between days 80-110 of pregnancy in ovariectomized gilts given progesterone to maintain pregnancy. To obtain an objective measurement of lobulo-alveolar (parenchymal) composition, mammary glands were cut in cross-section through the teat, and the area of parenchymal tissue on the exposed face of the gland was determined. Ovariectomy on day 80 or 100 followed by progesterone replacement therapy resulted in a dramatic reduction in the rate of growth of mammary parenchymal cross-section area on days 100 and 110 of gestation, respectively, compared to that in controls. In contrast, progesterone plus relaxin therapy, with highly purified porcine relaxin, restored the mammary parenchymal cross-section area to control values in ovariectomized gilts. Morphometric analysis of mammary tissue on day 110 of pregnancy indicated that both the absence of relaxin after ovariectomy and replacement therapy with porcine relaxin in ovariectomized gilts had little if any effect on the percentages of the lumen, stroma, or epithelial that comprised the mammary parenchyma. It is concluded that relaxin has a stimulatory effect on the growth of mammary parenchymal tissue during late gestation in the pig.
authors.affiliation: Department of Animal Sciences, University of Illinois, Urbana 61801.
authors.forename: W L
authors.initials: WL
authors.lastname: Hurley
authors.forename: R M
authors.initials: RM
authors.lastname: Doane
authors.forename: M B
authors.initials: MB
authors.lastname: O'Day-Bowman
authors.forename: R J
authors.initials: RJ
authors.lastname: Winn
authors.forename: L E
authors.initials: LE
authors.lastname: Mojonnier
authors.forename: O D
authors.initials: OD
authors.lastname: Sherwood
mesh_terms: D000818:Animals; D005260:Female; D008321:Mammary Glands, Animal / Q000254:growth & development*; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012016:Reference Values; D012065:Relaxin / Q000494:pharmacology*; D013552:Swine
chemical_list: D012065:Relaxin