The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma.
The suggestion that individuals with the GST1 0 phenotype have a greater susceptibility to carcinogens than those with other GST1 phenotypes has been examined by using a starch gel zymogram approach to compare the frequency of this phenotype in control subjects and a group of patients with adenocarcinoma of stomach and colon. A significantly greater proportion of the patients with adenocarcinoma demonstrated the null phenotype, odds ratio analysis indicating that individuals with this polymorphic variant have an approximately 3-fold greater risk of developing these cancers.
Strange
R C
RC
School of Postgraduate Medicine and Biological Sciences, University of Keele, North Staffordshire Hospital Centre, Hartshill, Stoke on Trent, UK.
Matharoo
B
B
Faulder
G C
GC
Jones
P
P
Cotton
W
W
Elder
J B
JB
Deakin
M
M
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype
D007527:Isoenzymes; D005982:Glutathione Transferase