title: A case of basophilic leukemia bearing simultaneous translocations t(8;21) and t(9;22).
abstract: We report a case of basophilic leukemia with simultaneous translocations of t(8;21) and t(9;22). The patient's clinical and hematologic findings were characteristic only of t(9;22) but not of t(8;21). This unusual cytogenetic phenomenon raises a challenge to the current concepts of primary chromosomal abnormalities in cancer.
authors.affiliation: Jiangsu Institute of Hematology, Leukemia Research Unit, Suzhou Medical College, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Xue
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: D R
authors.initials: DR
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: D W
authors.initials: DW
authors.lastname: Lu
authors.forename: J X
authors.initials: JX
authors.lastname: Gong
authors.forename: M H
authors.initials: MH
authors.lastname: Wang
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhu
authors.forename: B J
authors.initials: BJ
authors.lastname: Lin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D011241:Prednisone / Q000627:therapeutic use; D014178:Translocation, Genetic; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone