[Vecuronium bromide in pediatric anesthesia].
Ninety patients were included in a study to assess the clinical characteristics of vecuronium bromide used in children. The myorelaxant was administered to all patients using different routes. The use of vecuronium at a dose approximately equal to 1ED95 was characterised by a duration of action sufficient to allow its use in short operations; on the other hand, it also produced a long induction-intubation interval and not optimal conditions in which to perform intubation. Conditions for intubation improved during induction via inhalation and there was a reduced induction-intubation interval compared to intravenous induction using the same dose of vecuronium. A further reduction in intubation time was obtained by increasing the dose from 50 to 150 micrograms/kg-1 together with an increased clinical duration of action. The "priming principle" technique also allowed intubation time to be shortened without variations in the duration of action provided a full dose of vecuronium, 100 micrograms/kg-1, was used. However, this was also associated with a notable incidence of adverse reactions. Of the various combinations examined, the most advantageous association of pre-dose and interval between doses was the association of a pre-dose of 10 micrograms/kg-1 and an interval of 4 min between doses. Lower doses countered the advantages of priming, whereas higher doses resulted in an increased number of adverse reactions without producing notable changes in the intubation time.
Tartari
S
S
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Ferrara.
Marchi
M
M
Guberti
A
A
Vivarelli
R
R
Tosatti
S
S
Gritti
G
G
D000293:Adolescent; D000768:Anesthesia, General / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003975:Diazepam; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013511:Minor Surgical Procedures; D011229:Preanesthetic Medication; D013874:Thiopental; D014673:Vecuronium Bromide / Q000008:administration & dosage* / Q000009:adverse effects
D014673:Vecuronium Bromide; D013874:Thiopental; D003975:Diazepam