title: Effect of a single infusion of aminohydroxypropylidene on calcium and bone metabolism in healthy volunteers monitored during 2 months.
abstract: Recently, bisphosphonates have been used to prevent postmenopausal bone loss. As the effects of bisphosphonates on normal bone metabolism are unknown, 3-amino-1-hydroxypropylidene-1,1-diphosphonate (APD) was studied in healthy subjects. The effects of a single 20-mg APD infusion on biochemical parameters of calcium and bone metabolism were investigated during 2 months in 10 healthy male volunteers. This single moderate dose of APD reduced biochemical parameters of bone resorption during the time of follow-up. After 2 months, urinary hydroxyproline excretion was still below the basal level. The decreased serum calcium levels did not return to basal values. Biochemical parameters of bone formation, serum alkaline phosphatase and osteocalcin, showed a slight increase during the first month after stimulation of the parathyroids and a corresponding increase in serum 1,25-dihydroxyvitamin D. These formation parameters decreased thereafter, probably representing coupling between bone resorption and bone formation.
authors.affiliation: Department of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Netelenbos
authors.forename: F C
authors.initials: FC
authors.lastname: van Ginkel
authors.forename: P
authors.initials: P
authors.lastname: Lips
authors.forename: O R
authors.initials: OR
authors.lastname: Leeuwenkamp
authors.forename: R
authors.initials: R
authors.lastname: Barto
authors.forename: W J
authors.initials: WJ
authors.lastname: van der Vijgh
authors.forename: H
authors.initials: H
authors.lastname: van der Wiel
authors.forename: W H
authors.initials: WH
authors.lastname: Hackeng
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001846:Bone Development / Q000187:drug effects; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000652:urine; D004164:Diphosphonates / Q000494:pharmacology*; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007700:Kinetics; D008297:Male; D015675:Osteocalcin / Q000097:blood; D000077268:Pamidronate; D010710:Phosphates / Q000097:blood / Q000378:metabolism
chemical_list: D004164:Diphosphonates; D010710:Phosphates; D015675:Osteocalcin; D015650:24,25-Dihydroxyvitamin D 3; D003404:Creatinine; D000469:Alkaline Phosphatase; D002117:Calcitriol; D000077268:Pamidronate; D006909:Hydroxyproline; D002118:Calcium