title: Serum hyaluronan concentration determined by radiometric assay in patients with pretibial myxedema and Graves' ophthalmopathy.
abstract: The serum concentration of hyaluronan (HA) was measured by radiometric assay in patients with pretibial myxedema (PTM) and Graves' ophthalmopathy (GO). The mean HA concentration in the patients (n = 8) was 21.2 +/- 15.3 (mean +/- SD) microgram/l, while that of Graves' disease without skin or eye involvement (n = 7) was 23.5 +/- 11.0 (mean +/- SD) microgram/l and that of the control (n = 8) was 25.5 +/- 16.4 (mean +/- SD) microgram/l. We conclude that local accumulation of glycosaminoglycan in PTM or GO is not associated with an increase in the serum HA concentration.
authors.affiliation: Division of Endocrinology, Toranomon Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: R
authors.initials: R
authors.lastname: Odajima
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Shishiba
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005128:Eye Diseases / Q000378:metabolism; D005260:Female; D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D018828:Immunoglobulins, Thyroid-Stimulating; D007868:Leg Dermatoses / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000378:metabolism*; D013961:Thyroid Gland / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D014284:Triiodothyronine; D013972:Thyrotropin; D006820:Hyaluronic Acid; D013974:Thyroxine