Involvement of beta-adrenergic receptors in the differential release of gonadotropins in acutely orchidectomized rats.
To determine the differential release of gonadotropins in acutely orchidectomized rats, a single injection of the beta-adrenergic blocker Bornaprolol (FM 24) was administered to the animals and plasma FSH and LH levels were determined. FM 24 produced low plasma FSH levels only when injected 16 h before starting the blood collection and had no effect on FSH levels at 0, 30 and 46 h after its administration. However, it produced low LH plasma levels at 0, 16 and 30 h after administration. These findings confirm that pituitary beta-adrenergic receptors are involved in plasma LH release and suggest that they could also be involved in the differential release of FSH/LH.
Bedran-de-Castro
J C
JC
Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista, SP, Brasil.
Petrovic
S L
SL
McCann
S M
SM
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009919:Orchiectomy; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C018417:bornaprolol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone