title: Absence of central effects with levocabastine eye drops.
abstract: Twelve healthy volunteers were randomly allocated to receiving in a double-blind cross-over fashion levocabastine eye drops (0.5 mg/ml solution) and placebo. They were advised to instill 2 drops per eye, four times daily. Each treatment was administered for a period of 1 week. Before and after each treatment period psychomotor function was assessed using Critical Flicker Fusion Test and the Choice Reaction Time Test. At the same time intervals a subjective evaluation of sedation was given using a Visual Analogue of Sedation. Both objective and subjective measurements showed that no significant treatment effects could be detected. It is concluded that repeated instillations of levocabastine eye drops are devoid of any sedative side effects.
authors.affiliation: Dept. of Psychiatry, University of Lisbon, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Arriaga
authors.forename: N
authors.initials: N
authors.lastname: Rombaut
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010880:Piperidines / Q000097:blood / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D006634:Histamine H1 Antagonists; D009883:Ophthalmic Solutions; D010880:Piperidines; C047340:levocabastine