[The effect of dopaminergic pharmacological agents on the pancreatic islet apparatus in rats].
Experimental studies were carried out on white male sexual mature healthy rats with induced alloxan diabetes, to clarify the role of dopaminergic system in the regulation of functions of the insular apparatus of the pancreas. The experiments were performed by the following drugs: bromrcripine, levodopa, a combination of revodopa plus carbidopa and haloperidol. Parameters of carbohydrate metabolism were determined in the course of acute and chronic experiments. The results sustained the hypothesis for participation of dopaminergic system in the regulation of production and secretion of insulin and respectively in the control of carbohydrate metabolism. Independent studies were carried out on white rats with alloxan diabetes after combined administration of dopaminergic pharmacological drugs and sulphanylureic preparation (SUP)-glybenclimide. The mechanisms of interaction after the combined administration of the investigated drugs under the conditions of experimental diabetes mellitus were clarified. The obtained results supplement data, in support of the hypothesis for the role of dopamine as a neuromediator in the regulation of the insular apparatus of the pancreas.
Boiadzhieva
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D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D015259:Dopamine Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005905:Glyburide / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001786:Blood Glucose; D015259:Dopamine Agents; D005905:Glyburide