title: Gonyauline: a novel endogenous substance shortening the period of the circadian clock of a unicellular alga.
abstract: The circadian clock in the unicellular alga Gonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.
authors.affiliation: Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: T
authors.initials: T
authors.lastname: Roenneberg
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: L D
authors.initials: LD
authors.lastname: Cranmer
authors.forename: K
authors.initials: K
authors.lastname: Ryan
authors.forename: Y
authors.initials: Y
authors.lastname: Kishi
authors.forename: J W
authors.initials: JW
authors.lastname: Hastings
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D002940:Circadian Rhythm / Q000502:physiology*; D003521:Cyclopropanes / Q000737:chemistry / Q000302:isolation & purification*; D004141:Dinoflagellida / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D003521:Cyclopropanes; C067620:gonyauline