The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis.
DNA encoding the human aminopeptidase N (EC 3.4.11.2) gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.
Watt
V M
VM
Department of Physiology, University of Toronto, Ontario, Canada.
Willard
H F
HF
D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D018826:CD13 Antigens; D002478:Cells, Cultured; D002884:Chromosomes, Human, Pair 15; D004247:DNA / Q000302:isolation & purification*; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D015183:Restriction Mapping
D004247:DNA; D000626:Aminopeptidases; D018826:CD13 Antigens