Effects of somatostatin and motilin on the motor and myoelectrical activity of the canine stomach and small intestine in vivo.
The experiments were performed on six starved dogs with chronic fistula in the stomach and small intestine and with chronically implanted electrodes on the smooth-muscle wall of these organs. Motilin (15-25 ng/kg i.v.) induced fastedtype peristaltic contractions accompanied by migrating myoelectrical spike activity in the stomach and small intestine. Somatostatin (0.5-2 micrograms/kg i.v.) inhibited the spontaneous contractile activity and the spike potentials in both organs. The antagonistic effect of somatostatin on the spontaneous and motilin-induced contractions resembled the effect of atropine and probably resulted from the decreased acetylcholine release in the cholinergic neurons.
Milenov
K
K
Institute of Physiology, Bulgarian Academy of Sciences.
Bocheva
A
A
Vassileva
M
M
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009037:Motilin / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D013004:Somatostatin; D009037:Motilin; D001285:Atropine