title: Glycaemic effects of tentacle extract of the jellyfish Acromitus rabanchatu (Annandale).
abstract: Tentacle extract of the common jellyfish A. rabanchatu, caused glycaemic alteration in fasting rabbits. Intravenous administration of the extract produced a significant rise followed by a significant fall in blood sugar level. Glucose tolerance in rabbits was also significantly increased. Extract-mediated hypoglycaemic response was fully abolished in alloxan diabetic rabbits. Preliminary separation on Sephadex G 50 indicated the hypoglycaemic factor to be a non-lethal protein of molecular weight less than 20 kDa. Heat treatment of extract and G 50 separated fraction P2 demonstrated total loss of hypoglycaemic activity.
authors.affiliation: Department of Pharmacy, Jadavpur University, Calcutta, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Ghosh
authors.forename: A
authors.initials: A
authors.lastname: Gomes
authors.forename: A K
authors.initials: AK
authors.lastname: Nag Chaudhuri
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003064:Cnidarian Venoms / Q000302:isolation & purification / Q000633:toxicity*; D007003:Hypoglycemia / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000302:isolation & purification; D008297:Male; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D003064:Cnidarian Venoms; D007004:Hypoglycemic Agents