title: Differential development of angiotensin II receptor subtypes in the rat brain.
abstract: Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.
authors.affiliation: Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: K
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: J M
authors.initials: JM
authors.lastname: Saavedra
mesh_terms: D000375:Aging; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology; D007700:Kinetics; D019808:Losartan; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D007093:Imidazoles; D009842:Oligopeptides; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; C060894:CGP 42112A; D019808:Losartan