Immunoglobulin A mediation of murine nasal anti-influenza virus immunity.
Most mice which have recovered from influenza virus infection are immune to reinfection with the same influenza virus. This immunity could be abrogated by the intranasal instillation of anti-immunoglobulin A (anti-IgA) but not of anti-IgG or anti-IgM antiserum. Thus, IgA is the major, if not the sole, mediator of nasal immunity to influenza virus in immunocompetent mice.
Renegar
K B
KB
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0266.
Small
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PA
D000818:Animals; D005260:Female; D007108:Immune Tolerance; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009296:Nasal Cavity / Q000382:microbiology*; D009975:Orthomyxoviridae / Q000254:growth & development / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology; D014779:Virus Replication
D007070:Immunoglobulin A; D007075:Immunoglobulin M