Relationship of clastogenic effects of zirconium oxychloride to dose and duration of exposure in bone marrow cells of mice in vivo.
Zirconium oxychloride was administered as a single oral dose to laboratory-bred Swiss albino mice corresponding to 1/2, 1/6 and 1/20 of the LD50 values. Bone marrow cells were screened after 6, 12 and 24h for chromosomal aberrations following an air-drying-Giemsa schedule. The frequencies of chromosomal breaks and alterations induced increased significantly at a rate directly proportional to the concentration used. The increase was also related to the period after exposure, although to a less extent than the concentration used. No direct relationship could be observed to the sex of the animal.
Ghosh
S
S
Department of Botany, University of Calcutta, India.
Sharma
A
A
Talukder
G
G
D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002842:Chromatids / Q000187:drug effects*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D012737:Sex Factors; D015040:Zirconium / Q000633:toxicity*
D009153:Mutagens; D015040:Zirconium; C026090:zirconium oxychloride