Molecular analysis of protein assembly in muscle development.
The challenge presented by myofibril assembly in striated muscle is to understand the molecular mechanisms by which its protein components are arranged at each level of organization. Recent advances in the genetics and cell biology of muscle development have shown that in vivo assembly of the myofilaments requires a complex array of structural and associated proteins and that organization of whole sarcomeres occurs initially at the cell membrane. These studies have been complemented by in vitro analyses of the renaturation, polymerization, and three-dimensional structure of the purified proteins.
Epstein
H F
HF
Department of Neurology, Baylor College of Medicine, Houston, TX 77030.
Fischman
D A
DA
D000199:Actins / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009119:Muscle Contraction; D024510:Muscle Development; D009124:Muscle Proteins / Q000502:physiology*; D009210:Myofibrils / Q000502:physiology*; D009218:Myosins / Q000502:physiology; D011108:Polymers; D012508:Sarcolemma / Q000502:physiology
D000199:Actins; D046911:Macromolecular Substances; D009124:Muscle Proteins; D011108:Polymers; D009218:Myosins