Intrathecal and epidural somatostatin in rats: can antinociception, motor effects and neurotoxicity be separated?
In the present investigation, the antinociceptive, motor blocking and neurotoxic effects of intrathecal and epidural somatostatin (SST) were assessed in rats implanted with lumbar intrathecal and epidural catheters. The doses studied were 5, 7.5, 10, 12.5 and 15 micrograms intrathecally and 100, 250, 400 and 500 micrograms epidurally. It appears that if the intrathecal doses of SST are kept below 15 micrograms and the epidural doses below 250 micrograms, the prolonged tail-flick latency can be separated from the transient motor blockade. The antinociception appears not to be attributable to neurotoxicity by the histological evidence available.
Mollenholt
Peter
P
Department of Anesthesiology and Intensive Care, Örebro Medical Center Hospital, S-701 85 ÖrebroSweden Astra Alab AB, Research and Development Laboratories and Astra Toxicological Laboratories, S-151 85 SödertäljeSweden.
Post
Claes
C
Paulsson
Ivar
I
Rawal
Narinder
N
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007268:Injections, Epidural; D007278:Injections, Spinal; D008297:Male; D009068:Movement / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology
D013004:Somatostatin