Chemical mutagenesis and fine-structure functional analysis of the mouse genome.
Heritable mutations constitute important raw materials for mammalian developmental genetics and general genome studies. Mutations induced by high-efficiency chemical mutagenesis of germ cells in mice can be used in genetic and molecular studies to complement physical-mapping strategies and to examine the nature and extent of the functional complexities hidden within the mammalian genome.
Rinchik
E M
EM
Biology Division, Oak Ridge National Laboratory, TN 37831-8077.
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D005796:Genes / Q000502:physiology*; D005854:Germ Cells / Q000187:drug effects / Q000528:radiation effects; D051379:Mice / Q000235:genetics; D016296:Mutagenesis / Q000235:genetics*