The activity of several enzymes in the urine and blood of animals in experimental poisoning with sublimate. Part. II. Chronic poisoning.
Fourteen guinea pigs were injected with sublimate during the period of 3 months. Their urine and blood was examined. In the urine an increase of activity of alkaline phosphatase and lactate dehydrogenase was noted. In the blood plasma an increase of lactate dehydrogenase activity was observed and in the blood serum decrease of gamma-glutamyl-transpeptidase activity. The determination of alkaline phosphatase in urine is a sensitive indicator of renal damage caused by mercury. It has a greater diagnostic value than the determination of this enzyme in the blood serum.
Starnawska
M
M
Clinic of Occupational and Tropical Diseases, Institute of Maritime and Tropical Medicine, Gdynia.
Hać
E
E
D000469:Alkaline Phosphatase / Q000097:blood / Q000652:urine*; D000818:Animals; D002908:Chronic Disease; D006168:Guinea Pigs; D007527:Isoenzymes; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000652:urine*; D008297:Male; D008627:Mercuric Chloride / Q000378:metabolism / Q000506:poisoning*; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000652:urine
D007527:Isoenzymes; D008627:Mercuric Chloride; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase