Vitamin E derivatives as new potent inhibitors of microsomal lipid peroxidation.
Several synthetic Vitamin E derivatives are strong inhibitors of lipid peroxidation induced in rat liver microsomes either chemically by ferrous ions and ascorbate or enzymatically by NADPH and carbon tetrachloride. The relative activities of these inhibitors are consistent with their intrinsic antioxidant properties, as peroxyl radicals scavengers. Among them, a 3,4-dihydro-6-hydroxy-2H-1-naphtopyran with IC50 around 0.08 microM is one of the most potent yet known inhibitor of lipid peroxidation.
Battioni
J P
JP
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS URA 400, Paris, France.
Fontecave
M
M
Jaouen
M
M
Mansuy
D
D
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System