title: The structure of the homeodomain and its functional implications.
abstract: The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
authors.affiliation: University of Basel, Switzerland.
authors.forename: W J
authors.initials: WJ
authors.lastname: Gehring
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Affolter
authors.forename: A
authors.initials: A
authors.lastname: Percival-Smith
authors.forename: M
authors.initials: M
authors.lastname: Billeter
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Qian
authors.forename: G
authors.initials: G
authors.lastname: Otting
authors.forename: K
authors.initials: K
authors.lastname: Wüthrich
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000033:anatomy & histology / Q000235:genetics*; D005801:Genes, Homeobox; D008969:Molecular Sequence Data; D011487:Protein Conformation
chemical_list: D004247:DNA