title: The adsorption of salicylates by a milk chocolate-charcoal mixture.
abstract: OBJECTIVE
  To evaluate the adsorptive capacity of a milk chocolate-charcoal mixture to aspirin, compared with superactivated charcoal and conventional activated charcoal.
  
  
  METHODS
  A prospective, randomized, crossover study.
  
  
  METHODS
  The Massachusetts Poison Control Center office in The Children's Hospital, Boston.
  
  
  METHODS
  Six healthy adult volunteers with no known allergies to aspirin or chocolate, bleeding disorders, or peptic ulcer disease.
  
  
  METHODS
  Each participant ingested 975 mg of crushed aspirin on separate days, followed by either water; 10 g milk chocolate-charcoal mixture; 10 g SuperChar Liquid; or 10 g Actidose Aqua activated charcoal. Total serum salicylate concentrations were determined by high-performance liquid chromatography at zero, one, two, four, eight, and 24 hours after ingestion.
  
  
  RESULTS
  Neuman-Keuls analysis was used to measure time-to-peak concentration, which was reduced by SuperChar Liquid, 67%; milk chocolate-charcoal mixture, 106%; and activated charcoal, 56%. Aspirin absorption was calculated using Neuman-Keuls analysis to measure area under the concentration-time curve. Total aspirin absorption was reduced by SuperChar, 67%; milk chocolate-charcoal mixture, 50%; and activated charcoal, 2%. There was no difference in serum salicylate concentrations between SuperChar and milk chocolate-charcoal mixture at all time intervals. Also, all serum salicylate concentrations with milk chocolate-charcoal mixture were consistently lower than with activated charcoal.
  
  
  CONCLUSIONS
  Although the formulation of milk chocolate with activated charcoal reduces its adsorptive capacity compared with superactivated charcoal, it is still able to bind aspirin effectively and is superior to conventional activated charcoal. Further research may improve the binding and palatability of milk chocolate-charcoal mixture, especially for home use.
authors.affiliation: Division of Clinical Pharmacology/Toxicology, Children's Hospital, Boston, Massachusetts.
authors.forename: T F
authors.initials: TF
authors.lastname: Eisen
authors.forename: P A
authors.initials: PA
authors.lastname: Grbcich
authors.forename: P G
authors.initials: PG
authors.lastname: Lacouture
authors.forename: M W
authors.initials: MW
authors.lastname: Shannon
authors.forename: A
authors.initials: A
authors.lastname: Woolf
mesh_terms: D000327:Adsorption; D000328:Adult; D001241:Aspirin / Q000097:blood / Q000493:pharmacokinetics*; D002099:Cacao; D002606:Charcoal; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011446:Prospective Studies
chemical_list: D002606:Charcoal; D001241:Aspirin