[In vitro studies of the adsorption behavior of Wofatit Y 88 in relation to various drugs].
The adsorber Wofatit Y 88 (VEB Chemiekombinat Bitterfeld) was tested regarding its adsorption properties in comparison with Hämoresin (B. Braun, Melsungen, FRG) Hemosorbent SKN-2K (USSR) and the own product Wofatit UH 91. As adsorptives the hypnotics Metaqualon, Pyrithyldion, Crotylbarbital and Phenobarbital were used. The investigation have been performed in a single-pass system in a relation of 1:25 to the clinical practice conditions. The concentration measurements to the estimation of adsorbed amounts were made by UV-VIS spectrometry. It was found that Wofatit Y 88 is superior to Hämoresin with regard to adsorbed amounts and adsorption speed. For all drugs Wofatit Y 88 was superior to UH 91.
Demme
U
U
Nephrologische Abteilung, Friedrich-Schiller-Universität Jena.
Günther
K
K
Werner
R
R
Schwachula
G
G
Kehnscherper
R
R
Stein
G
G
Feistel
L
L
Junge
W
W
D000327:Adsorption; D001463:Barbiturates / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D001783:Blood Flow Velocity / Q000502:physiology; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000502:physiology; D008702:Methaqualone / Q000493:pharmacokinetics; D010634:Phenobarbital / Q000493:pharmacokinetics; D011137:Polystyrenes; D011728:Pyridones / Q000493:pharmacokinetics
D001463:Barbiturates; D006993:Hypnotics and Sedatives; D011137:Polystyrenes; D011728:Pyridones; D008702:Methaqualone; C005589:pyrithyldione; C000517:crotarbital; D010634:Phenobarbital