[Localization of RFLP probe Fr. 3-42 at 16p 13 band by in situ hybridization].
Recombinant plasmid clone Fr. 3-42(HGM9 no. D16S21) containing a human single-copy DNA segment of 1.9kb was hybridized to human chromosome preparations. Twenty-eight percent of hybridized metaphases exhibited silver grains at the terminal region of short arm of chromosome 16 (16p13). Close linkage between this probe and the human alpha 1 hemoglobin gene was demonstrated in another study.
Xiao
G H
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Central Laboratory, First Affiliated Hospital Hunan Medical University, Changsha.
D002885:Chromosomes, Human, Pair 16; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length