title: Technetium-99m nanocolloid for the scintigraphic assessment of inflammatory bowel disease in the colon: its value in comparison with indium-111-labelled granulocytes.
abstract: The usefulness of 99mTc-nanocolloid for the assessment of localization and disease activity of colitis in patients suffering from inflammatory bowel disease (IBD) was investigated in 10 patients. Results of 99mTc-nanocolloid scintigraphy were compared with Indium-111 autologous granulocyte scintigraphy and the activity index according to Van Hees. In none of the patients a true positive result of the 99mTc-nanocolloid scintigraphy was encountered, while 111In-granulocyte scintigraphy was positive in 7 of 10 patients with active disease. Radioactivity became visible in the small bowel starting 2 h after injection of 99mTc-nanocolloid most likely because of excretion by the liver of degradation products of the radiopharmaceutical. The authors conclude that despite a previous communication 99mTc-nanocolloid cannot replace 111In-granulocytes for the assessment of IBD patients with active colitis.
authors.affiliation: Division of Nuclear Medicine (Department of Diagnostic Radiology), University Hospital, Leiden, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Arndt
authors.forename: A
authors.initials: A
authors.lastname: van der Sluys Veer
authors.forename: D
authors.initials: D
authors.lastname: Blok
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D000328:Adult; D000368:Aged; D003106:Colon / Q000000981:diagnostic imaging; D005260:Female; D006098:Granulocytes; D006801:Humans; D007205:Indium Radioisotopes; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D007205:Indium Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin