Congenital Letterer-Siwe disease with intrauterine fetal death: a case report and review of the literature.
Letterer-Siwe disease is a rare proliferative disorder of the Langerhans cells, usually encountered inpatients under the age of 3 years. We present an unusual case of intrauterine fetal death at the 28th gestational week associated with generalized papular skin eruptions and systemic histiocytic infiltrates characteristic of Letterer-Siwe disease. Histopathologic features of Langerhans cells were further confirmed by immunocytochemistry and electron microscopy. The events occurring in pregnancy which may be worth mentioning are: (1) routine chest P-A view X-ray exposure of the mother 2 days before LMP, (2) the mother was exposed to certain Chinese herbs, in particular, the 101 hair growth solution (A Chinese herb mixture used for alopecia; contents unknown) from assisting her husband in topical applications, and (3) the mother has worked in front of computer monitors 8 hours a day for 10 years.
Yu
C P
CP
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Tseng
H H
HH
Tu
Y C
YC
D000328:Adult; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital* / Q000473:pathology; D006801:Humans; D008297:Male; D011247:Pregnancy; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins