title: A double-blind comparative study of remoxipride and thioridazine in the acute phase of schizophrenia.
abstract: Sixty-one patients with acute schizophrenia received either remoxipride (75-375 mg daily) or thioridazine (150-750 mg daily) for 6 weeks. There was no statistically significant between-drug difference in improvement in mental state, as measured by the Brief Psychiatric Rating Scale, although the trend favoured thioridazine; global assessment of illness severity at the last rating also favoured thioridazine. Sedation, anticholinergic effects, autonomic dysfunction, and weight gain were significantly more common in patients receiving thioridazine. Both drugs produced few extrapyramidal effects, but both were associated with cardiovascular changes in two patients; neither drug produced significant abnormalities in laboratory tests.
authors.affiliation: Crichton Royal Hospital, Dumfries, United Kingdom.
authors.forename: R G
authors.initials: RG
authors.lastname: McCreadie
authors.forename: N
authors.initials: N
authors.lastname: Todd
authors.forename: M
authors.initials: M
authors.lastname: Livingston
authors.forename: D
authors.initials: D
authors.lastname: Eccleston
authors.forename: J A
authors.initials: JA
authors.lastname: Watt
authors.forename: R N
authors.initials: RN
authors.lastname: Herrington
authors.forename: D
authors.initials: D
authors.lastname: Tait
authors.forename: G
authors.initials: G
authors.lastname: Crocket
authors.forename: M J
authors.initials: MJ
authors.lastname: Mitchell
authors.forename: B
authors.initials: B
authors.lastname: Huitfeldt
mesh_terms: D000208:Acute Disease; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy*; D017330:Remoxipride; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013881:Thioridazine / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides; D017330:Remoxipride; D013881:Thioridazine