Electroretinographic effects induced in humans by psychopharmacologic agents.
We studied the effects of single doses of different dopamine agonists and antagonists on the electroretinogram of a group of healthy volunteers. The results demonstrated significant b-wave amplitude changes after drug administration, suggesting that electroretinograms can be employed to evaluate the effects on retinal dopaminergic activity induced by psychotropic drugs and that the study of the electroretinographic effects of psychopharmacologic agents can provide new insights into the relationship between retinal dopaminergic mechanisms and the electroretinogram b-wave origin.
Perossini
M
M
Eye Clinic, University of Pisa, Italy.
Fornaro
P
P
D000328:Adult; D003623:Dark Adaptation / Q000187:drug effects; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004566:Electrodes; D004596:Electroretinography / Q000187:drug effects*; D006801:Humans; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D011619:Psychotropic Drugs