Human atherosclerotic coronary artery xenografts: a model for investigation of transluminal recanalization.
A model for testing transluminal recanalization techniques was developed. Fragments of human atherosclerotic coronary arteries were transplanted into carotid arteries of dogs and evaluated by angiographic, angioscopic, and histologic study within a three-month period. An inflammatory response was most intense within the first week. By two weeks no inflammation was noted. Total occlusion (n = 13) and stenosis (n = 11) of the carotid arteries were achieved without complications. The model is easy to produce within a short period and the arterial occlusion resembles human vascular disease. This model has been used to evaluate laser recanalization of vascular obstructions.
Weber
H
H
Division of Cardiology, Hospital Bogenhausen, Munich, West Germany.
Ruprecht
L
L
Enders
S
S
D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003331:Coronary Vessels / Q000473:pathology / Q000637:transplantation*; D004195:Disease Models, Animal; D004285:Dogs; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D014183:Transplantation, Heterologous