title: Philadelphia chromosome-positive chronic myelogenous leukemia in treated Hodgkin's disease.
abstract: A patient who developed Philadelphia (Ph) chromosome-positive chronic myelogenous leukemia (CML) 8 years after successful treatment for Hodgkin's disease (HD) is reported. The Ph chromosome with a typical 9(22) translocation was identified by banding techniques in 80% of bone marrow (BM) cells. Southern blot analysis showed breakpoint cluster region (BCR) rearrangement as observed in classical CML. Until now, only three cases of Ph + CML have been reported after treatment for HD. At present, it is not clear whether development of CML after HD represents a therapy-induced complication, an increased susceptibility to secondary malignancies owing to the malignant process itself, a consequence of the immunological deficiencies in HD, or possibly a genetic susceptibility to malignancy.
authors.affiliation: Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: G E
authors.initials: GE
authors.lastname: Verhoef
authors.forename: H
authors.initials: H
authors.lastname: Demuynck
authors.forename: M S
authors.initials: MS
authors.lastname: Stul
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: H
authors.initials: H
authors.lastname: Van Den Berghe
authors.forename: M A
authors.initials: MA
authors.lastname: Boogaerts
mesh_terms: D015139:Blotting, Southern; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000032:analysis; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D014178:Translocation, Genetic
chemical_list: D004247:DNA