Mild renal failure induced by subchronic exposure to molybdenum: urinary kallikrein excretion as a marker of distal tubular effect.
In this study we investigated the effect of two molybdenum (Mo) doses (40 and 80 mg/kg/d) on renal function. Neither dose of Mo was able to induce significant hypertension in treated animals. Subchronic exposure to high doses of Mo resulted in a delay in body weight gain associated with mild renal failure marked by a decrease in glomerular filtration. An increase in diuresis and urinary kallikrein excretion associated with unchanged glycosuria and proximal tubular enzymuria (alanine aminopeptidase and gamma-glutamyl transpeptidase) evoked a preferential mild effect at the distal tubule.
Bompart
G
G
INSERM U-133, Faculté de Médecine, Toulouse, France.
Pécher
C
C
Prévot
D
D
Girolami
J P
JP
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000201:enzymology / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D018826:CD13 Antigens; D004305:Dose-Response Relationship, Drug; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007610:Kallikreins / Q000652:urine*; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008982:Molybdenum / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D015415:Biomarkers; D008982:Molybdenum; D005723:gamma-Glutamyltransferase; D000626:Aminopeptidases; D018826:CD13 Antigens; D007610:Kallikreins