title: Histidine, histamine, and the neuroregulation of food intake: a review and hypothesis.
abstract: Feeding, a behavior regulated by the central nervous system (CNS), includes the acquisition of specific essential nutrients and the maintenance of energy balance. Modulation of feeding behavior is a normal part of survival, but certain pathological conditions interrupt or modify regulatory aspects of feeding, thereby leading to inappropriate intake. This review examines aspects of metabolism associated with the anorexia seen in animals suffering from protein-energy malnutrition (PEM). The main focus is the indispensable amino acid histidine (His), the biosynthetic precursor of the neurotransmitter histamine (HA). In kwashiorkor-like PEM, His is elevated in plasma and brain, whereas all other indispensable amino acids are decreased. The elevation of His in the brain is to concentrations five times normal. Because the rate of HA synthesis in the brain is a function of the His concentration, His elevation raises the possibility of a profound direct effect of CNS function. In children, PEM consistently produces the symptoms of depressed food intake, edema, growth failure, and psychomotor changes. One known central effect of HA is the stimulation of ACTH and corticosteroid release. Based on these observations, the hypothesis being examined is as follows: one component of the pathophysiological neuroregulation of food intake involved the His-induced variation of HA concentration in the hypothalamus and the subsequently altered neurochemical activity at the corticotropin-releasing factor (CRF) neurons o the paraventricular nucleus (PVN).
authors.affiliation: Department of Biochemistry, School of Medicine, Oral Roberts University, Tulsa, Oklahoma.
authors.forename: L P
authors.initials: LP
authors.lastname: Mercer
authors.forename: S J
authors.initials: SJ
authors.lastname: Dodds
authors.forename: M D
authors.initials: MD
authors.lastname: Weber
authors.forename: J D
authors.initials: JD
authors.lastname: Dunn
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D004435:Eating / Q000502:physiology*; D006632:Histamine / Q000502:physiology*; D006639:Histidine / Q000502:physiology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000503:physiopathology; D011502:Protein-Energy Malnutrition / Q000503:physiopathology
chemical_list: D018377:Neurotransmitter Agents; D006639:Histidine; D006632:Histamine