Palmitate and stearate kinetics in the rat during sepsis and trauma.
Kinetics of plasma free palmitate and stearate were measured in control and septic-traumatized rats to determine the contribution plasma free fatty acids make to increased resting energy expenditure. Measurements were made at 24 hr after insult using a primed, 4-hr continuous infusion of selected (1-14C) fatty acid. The plasma concentration of palmitate was increased and stearate was decreased in sepsis-trauma rats compared to plasma concentrations in healthy control rats. Fatty acid turnover rates during sepsis-trauma were changed from control turnover rates in the same direction as plasma concentrations. Oxidation rates for palmitate and stearate at 24 hr after induction of sepsis-trauma were not different from oxidation rates in control rats. Plasma free fatty acids were concluded not to exhibit increased oxidation after sepsis-trauma and not to contribute extra energy during hypercatabolism. This finding contrasts with glucose and amino acids which have an increased oxidation rate during hypercatabolism.
Cardwell
R J
RJ
Department of Surgery, Medical College of Ohio, Toledo 43699-0008.
Birkhahn
R H
RH
Crist
K A
KA
Lee
E M
EM
Thomford
N R
NR
D000818:Animals; D004734:Energy Metabolism; D007700:Kinetics; D008297:Male; D010084:Oxidation-Reduction; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000097:blood*; D013229:Stearic Acids / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood*
D010169:Palmitic Acids; D013229:Stearic Acids; D019308:Palmitic Acid; C031183:stearic acid