Effect of indomethacin on opioid-induced gastric protection in cold-restrained stress.
Morphine and the synthetic opioid met-enkephalin analog [D-Ala2, MePhe4, Met(0)5ol] enkephalin (FK 33-824) injected intraperitoneally to rats at doses of 5-20 and 0.5-2 mg/kg respectively showed a protective effect on gastric lesion induced by cold-restraint stress. This protective effect was abolished by pretreatment with indomethacin. This suggests a role for prostaglandins in the protection, induced by opioids of the gastric mucosa against the development of stress-induced ulcers.
Scoto
G M
GM
Inst. of Pharmacology and Pharmacognosy, Faculty of Pharmacy, Univ. of Catania, Italy.
Parenti
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C
Scoto
E
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Spadaro
C
C
Arrigo-Reina
R
R
D000818:Animals; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications* / Q000378:metabolism
D009294:Narcotics; D011453:Prostaglandins; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D009020:Morphine; D007213:Indomethacin