title: Effects of long-term sensory vs. sympathetic denervation on the distribution of calcitonin gene-related peptide and tyrosine hydroxylase immunoreactivities in the rat lung.
abstract: In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long-term chemosympathectomy a marked increase of CGRP-immunoreactive nerve fibers was seen in the sections, while TH-immunoreactive nerve fibers appeared depleted. Inversely, long-term sensory denervation resulted in an increase of TH-immunoreactive nerve fibers with a sharp decrease of CGRP-immunostained fibers. These results suggest a peripheral interaction between these innervation systems in the lung, the mechanism of which has still to be elucidated.
authors.affiliation: Laboratory of Histopathology, Faculty of Medicine, Catholic University Leuven, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Van Ranst
authors.forename: J M
authors.initials: JM
authors.lastname: Lauweryns
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis* / Q000276:immunology; D008168:Lung / Q000737:chemistry / Q000294:innervation*; D009412:Nerve Fibers / Q000737:chemistry; D009475:Neurons, Afferent / Q000502:physiology*; D051381:Rats; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis* / Q000276:immunology; D014628:Vagotomy
chemical_list: D014446:Tyrosine 3-Monooxygenase; D015740:Calcitonin Gene-Related Peptide