Changes in the phospholipid content in the left heart ventricle of male mice during repeated administration of isoprenaline.
1. Male mice were injected 5 mg/kg isoprenaline (IPRO) daily and the heart weight, dry weight and phospholipid content in the left ventricle determined 24 hr after the last injection on days 1, 3, 5 and 10. 2. The phospholipid content sinks during the experiment, but the onset of the change is different in different phospholipids: for diphosphatidylglycerol it is clearly significant after 3 days, for phosphatidylcholine and phosphatidylethanolamine after 5 days and for sphingomyelin after 10 days; the relative amplitude of the change in this latter phospholipid was greatest of all. 3. If IPRO is given for 3 days and physiological saline for next 7 days, the content of some phospholipids (PE, SM and PG) continued to decrease. This suggests an important delayed effect of IPRO action.
Drnková
J
J
Department of Animal Physiology and Developmental Biology Faculty of Natural Sciences, Charles University, Prague, Czechoslovakia.
Nováková
O
O
Kubista
V
V
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D013997:Time Factors
D010743:Phospholipids; D007545:Isoproterenol