title: Rarity of preclinical alcoholic cardiomyopathy in chronic alcoholics less than 40 years of age.
abstract: Preclinical alcoholic cardiomyopathy, myocardial damage in the absence of overt congestive heart failure in chronic alcoholics, is well characterized at necropsy, but attempts to identify such a clinical entity before death have produced conflicting results. Studying subjects only at rest, the inclusion of older alcoholics and limitations of noninvasive techniques may explain some of the disagreement. To determine if preclinical alcoholic cardiomyopathy could be identified independent of the aforementioned limitations, 25 asymptomatic chronic alcoholics aged less than 40 years (mean 34), each of whom had consumed a minimum of 1 pint of whiskey or one 6-pack of beer greater than or equal to 5 days per week for greater than or equal to 5 years, underwent radionuclide ventriculography for measurements of systolic and diastolic function at rest, peak supine exercise and during recovery, and echocardiography for assessment of chamber size, wall thickness and left ventricular mass. Red blood cell levels of selenium and thiamine were measured to determine whether abnormalities were present in these 2 potential mediators of alcoholic cardiomyopathy. For comparison, an age-matched group of healthy control subjects was also studied. For alcoholics and control subjects at rest, mean ejection fraction (67 +/- 7% vs 71 +/- 6%) and diastolic peak filling rate (3.4 +/- 0.6 vs 3.3 +/- 0.6 end-diastolic volumes per second [EDV/s]) were similar.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Cardiology Section, Seattle Veterans Affairs Medical Center, Washington 98108.
authors.forename: M D
authors.initials: MD
authors.lastname: Cerqueira
authors.forename: G D
authors.initials: GD
authors.lastname: Harp
authors.forename: J L
authors.initials: JL
authors.lastname: Ritchie
authors.forename: J R
authors.initials: JR
authors.lastname: Stratton
authors.forename: R D
authors.initials: RD
authors.lastname: Walker
mesh_terms: D000328:Adult; D002310:Cardiomyopathy, Alcoholic / Q000175:diagnosis / Q000453:epidemiology*; D004452:Echocardiography; D005080:Exercise Test; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male; D012643:Selenium / Q000097:blood; D012746:Sexual Abstinence; D013831:Thiamine / Q000097:blood
chemical_list: D012643:Selenium; D013831:Thiamine