[Morphofunctional characteristics of the heart mitochondria during adrenergic stimulation and blockade under ketamine anesthesia].
A reduction of breathing control in palmitoylcarnitine oxidation without changes in phosphorylation efficacy coefficient have been noted upon intraabdominal injections of ketamine to rats at a dose of 50 mg/kg. The morphological signs noted were: mitochondrial matrix induration and insignificant focal disturbances of cardiac apparatus (myofibril) contractility. In beta-adrenergic stimulation of the heart by novodrine during ketamine anesthesia a sharp reduction in breathing control and phosphorylation efficacy coefficient are observed with the oxidation of succinate, caprylic acids and palmitoylcarnitine by myocardial mitochondria. Morphologically the disturbance of mitochondrial cysts, appearance of mitochondrial myelinic structures and partial destruction of mitochondrial membranes have been observed. In beta-adrenergic heart blockade by adrenoblockers obsidan and cordanum during ketamine anesthesia, obsidan induces an increase in phosphorylation efficacy coefficient, with morphologically normal energy and contractility apparatus. Cordanum is not so effective when used during ketamine anesthesia.
Abidova
S S
SS
Khoroshaev
V A
VA
Leonov
F V
FV
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D007649:Ketamine; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D007649:Ketamine