title: Genetic mapping in the region of the mouse X-inactivation center.
abstract: The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, United Kingdom.
authors.forename: J T
authors.initials: JT
authors.lastname: Keer
authors.forename: R M
authors.initials: RM
authors.lastname: Hamvas
authors.forename: N
authors.initials: N
authors.lastname: Brockdorff
authors.forename: D
authors.initials: D
authors.lastname: Page
authors.forename: S
authors.initials: S
authors.lastname: Rastan
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004303:Dosage Compensation, Genetic; D009115:Muridae / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome