title: The juxtaglomerular apparatus of the spontaneously hypertensive rat.
abstract: Spontaneously hypertensive rats (SHR) are used to study the pathogenesis of essential hypertension. This study investigates the role of the renin-angiotensin system (RAS) in the pathogenesis of hypertension in SHRs and the morphometry of the JGA by a three-dimensional computer reconstruction program "GLOM" and electron microscopy. Systolic blood pressure (SBP) (tail cuff method) was higher in SHRs compared to controls (P less than 0.001). Plasma renin concentration (PRC) was lower in SHRs than in controls (P less than 0.001). Reconstruction of the JGA revealed granulated JG cells in the afferent and efferent arterioles and in the vascular tree away from the JGA area. Electron microscopy showed granulated JG cells in the afferent and efferent arterioles. The percentage volume of the granulated JG cells in SHR was significantly higher than in controls (P less than 0.01). A relationship was found between the percentage volume of granulated JG cells and the SBP in SHRs (r = 0.933, P less than 0.05). The wall/lumen perimeter ratio was also significantly higher in the SHRs compared to the controls (P less than 0.05). Low PRC in SHRs has been reported by several workers. The apparent hyperactivity of the JGA may indicate failure of renin release or an abnormal synthesis/secretion rate.
authors.affiliation: Cumberland Kidney Research Laboratories, Pathology Department, Royal Victoria Infirmary, Newcastle Upon Tyne.
authors.forename: A H
authors.initials: AH
authors.lastname: Faraj
authors.forename: A R
authors.initials: AR
authors.lastname: Morley
authors.forename: G B
authors.initials: GB
authors.lastname: Lindop
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood
chemical_list: D012083:Renin