title: Effects of high-dose IgG on survival of surgical patients with sepsis scores of 20 or greater.
abstract: Sixty-two consecutive septic surgical patients receiving standard multimodal intensive care unit treatment who developed a sepsis score of 20 or greater (day 0) were randomized to receive 0.4 g/kg of either intravenous IgG (29 patients) or human albumin (controls; 33 patients), repeated on days +1 and +5, in a prospective, double-blind, multicenter study. The two groups were similar in age, initial sepsis scores, and acute physiology and chronic health evaluation II score. A significantly lower mortality was recorded in the IgG-treated group (38%) than in controls (67%). Septic shock was the cause of death in 7% of IgG-treated patients and in 33% of controls. The results of this study indicate that high-dose IgG improves survival and decreases death from septic shock in surgical patients with a sepsis score of 20 or greater.
authors.affiliation: Department of Surgery, University of Pavia, Varese, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Dominioni
authors.forename: R
authors.initials: R
authors.lastname: Dionigi
authors.forename: M
authors.initials: M
authors.lastname: Zanello
authors.forename: M
authors.initials: M
authors.lastname: Chiaranda
authors.forename: R
authors.initials: R
authors.lastname: Dionigi
authors.forename: A
authors.initials: A
authors.lastname: Acquarolo
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
authors.forename: C
authors.initials: C
authors.lastname: Sguotti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use; D001424:Bacterial Infections / Q000401:mortality*; D002423:Cause of Death; D003422:Critical Care; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D010919:Placebos; D011446:Prospective Studies; D012307:Risk Factors; D013514:Surgical Procedures, Operative; D015996:Survival Rate
chemical_list: D000418:Albumins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009961:Orosomucoid; D010919:Placebos