Effects of ingested crude oil on thyroid hormones and on the mixed function oxidase system in ducks.
1. Ingestion of Statfjord A crude oil from the North Sea has no apparent effect on the metabolic rate of ducks (Jenssen, 1989). This may be because this particular oil does not affect plasma concentrations of thyroid hormones and enzyme activities in the mixed function oxidase (MFO) system of ducks. 2. To test this hypothesis, plasma concentrations of thyroid hormones (thyroxine and triiodothyronine), and levels of hepatic cytochrome P-450 and enzyme activities (NADPH cytochrome C reductase and GSH-S-transferase) in the MFO system were measured in domestic ducks (Anas platyrhynchos) which had ingested this crude oil. 3. Daily oral of 5 ml crude oil per kg body weight for 6 consecutive days resulted in a 53% increase in plasma triiodothyronine concentration and a 56% increase in the hepatic cytochrome P-450 level. The changes in these parameters were apparently not sufficient to cause any rise in metabolic heat production. 4. This apparent contradiction is probably because activation of the MFO-system is energetically inexpensive. Also, possible metabolic effects caused by increased plasma-triiodothyronine concentration and activation of the MFO-system may have been masked by an inhibitory effect of the crude oil on mitochondrial electrontransport and coupled phosphorylation.
Jenssen
B M
BM
Department of Zoology, University of Trondheim, Dragvoll, Norway.
Ekker
M
M
Zahlsen
K
K
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003600:Cytosol / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010578:Petroleum / Q000633:toxicity*; D011506:Proteins / Q000378:metabolism; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D014874:Water Pollutants, Chemical / Q000633:toxicity
D010578:Petroleum; D011506:Proteins; D014874:Water Pollutants, Chemical; D014284:Triiodothyronine; D006899:Mixed Function Oxygenases; D009245:NADH Dehydrogenase; D005982:Glutathione Transferase; D013974:Thyroxine