Adrenal responses and neurotransmitters in posterior hypothalamic deafferentation.
The effects of a small posterior hypothalamic deafferentation (PHD) on adrenocortical responses to peripheral neural stimuli were investigated in rats. PHD inhibited the rise in plasma corticosterone (CS) following photic and acoustic stimulation, but did not affect the adrenocortical response following sciatic nerve stimulation. PHD did not change the content of norepinephrine in the paraventricular nucleus of the hypothalamus, however, it reduced the serotonin content by about 30%. The possible role of serotonin or of another tonic caudal input into the hypothalamus for the activation of the pituitary-adrenocortical axis, following certain neural stimuli, is discussed.
Feldman
S
S
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Conforti
N
N
Saphier
D
D
D000161:Acoustic Stimulation; D000302:Adrenal Cortex / Q000378:metabolism / Q000502:physiology; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004558:Electric Stimulation; D007034:Hypothalamus, Posterior / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008474:Medial Forebrain Bundle / Q000378:metabolism / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010775:Photic Stimulation; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology; D012701:Serotonin / Q000378:metabolism
D018377:Neurotransmitter Agents; D012701:Serotonin; D003345:Corticosterone; D009638:Norepinephrine