Does intraperitoneal CA-125 reflect disease status?
The relationship of serum CA-125 to intraperitoneal (IP) CA-125 was studied in 45 patients with a variety of gynecologic diseases including ovarian carcinoma. In 43 of 45 patients the IP level exceeded the serum level of CA-125. Paracentesis may dramatically alter both levels, thus mimicking surgical debulking. All IP levels of CA-125 measured at second-look coeliotomy for the ovarian cancer patients were within the normal range of IP CA-125 measured at surgery for benign disease. Therefore, intraperitoneal CA-125 is less sensitive than serum CA-125 in predicting intraperitoneal disease status. Likewise it cannot be used to predict the subgroup of ovarian cancer patients with negative second-look coeliotomy who are destined to develop a recurrence of disease.
Buller
R E
RE
Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange 92668.
Manetta
A
A
Bloss
J D
JD
DiSaia
P J
PJ
Berman
M L
ML
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000097:blood; D001202:Ascitic Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010532:Peritoneal Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D011863:Radioimmunoassay
D015295:Antigens, Tumor-Associated, Carbohydrate