title: Endometrial histology after first trimester spontaneous abortion.
abstract: The endometrial histology after spontaneous abortion was investigated by performing an endometrial biopsy in the two menstrual cycles subsequent to miscarriage in 12 women. In the first cycle, 66% (8/12) of the biopsies had the following abnormalities: (1) proliferative endometrium (n = 4), (2) proliferative glands and decidualized stroma (n = 1), (3) endometritis (n = 1), and (4) luteal insufficiency (n = 2). In the second cycle, 20% (2/10) of the biopsies demonstrated luteal insufficiency. Forty-five percent (10/22) of the first two cycles after spontaneous abortion demonstrated abnormal endometrial histology, with the first appearing more abnormal than the second (P = 0.06). Two conceptions occurred during the study period; both were uneventful term pregnancies. These findings suggest that a large proportion of the first two menstrual cycles after spontaneous abortion and curettage are abnormal, with the first cycle being more frequently abnormal than the second.
authors.affiliation: Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405.
authors.forename: S T
authors.initials: ST
authors.lastname: Nakajima
authors.forename: J R
authors.initials: JR
authors.lastname: Brumsted
authors.forename: J L
authors.initials: JL
authors.lastname: Deaton
authors.forename: K M
authors.initials: KM
authors.lastname: Blackmer
authors.forename: M
authors.initials: M
authors.lastname: Gibson
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D001706:Biopsy; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D011247:Pregnancy; D011261:Pregnancy Trimester, First