P-glycoprotein and drug resistance in acute leukemias and in the blastic crisis of chronic myeloid leukemia.
The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P-glycoprotein can be expressed constitutively in some cases; c) P-glycoprotein does not appear to be the only mechanism responsible for resistance towards anthracyclines and Etoposide.
Carulli
G
G
Unità di Ematologia, Università di Pisa, Italy.
Petrini
M
M
Marini
A
A
Vaglini
F
F
Caracciolo
F
F
Grassi
B
B
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001752:Blast Crisis / Q000097:blood* / Q000188:drug therapy; D004351:Drug Resistance; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000097:blood*; D009363:Neoplasm Proteins / Q000097:blood*; D009360:Neoplastic Cells, Circulating; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D014410:Tumor Stem Cell Assay
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins