title: The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study.
abstract: We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose [18FDG]). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis.
authors.affiliation: S. H. Fréderic Joliot, CEA, Orsay, France.
authors.forename: D
authors.initials: D
authors.lastname: Duboc
authors.forename: A
authors.initials: A
authors.lastname: Kahan
authors.forename: B
authors.initials: B
authors.lastname: Maziere
authors.forename: C
authors.initials: C
authors.lastname: Loc'h
authors.forename: C
authors.initials: C
authors.lastname: Crouzel
authors.forename: C J
authors.initials: CJ
authors.lastname: Menkès
authors.forename: B
authors.initials: B
authors.lastname: Amor
authors.forename: G
authors.initials: G
authors.lastname: Strauch
authors.forename: F
authors.initials: F
authors.lastname: Guérin
authors.forename: A
authors.initials: A
authors.lastname: Syrota
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D011197:Potassium Radioisotopes; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D011197:Potassium Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D009543:Nifedipine