title: Mutational analysis of the carboxyl terminus of the Moloney murine leukemia virus integration protein.
abstract: The integration protein (IN) is required for retrovirus DNA integration into the host DNA. The function of the C terminus of the Moloney murine leukemia virus IN protein was examined. The terminal 28 amino acids were found to be nonessential. A linker insertion at position 6025, within a 36-amino-acid insertion not found in any other retrovirus, also produced viable virus.
authors.affiliation: Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.
authors.forename: M J
authors.initials: MJ
authors.lastname: Roth
mesh_terms: D000818:Animals; D001287:Attachment Sites, Microbiological; D002478:Cells, Cultured; D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000235:genetics*; D004279:DNA, Viral / Q000378:metabolism*; D019426:Integrases; D008979:Moloney murine leukemia virus / Q000235:genetics* / Q000254:growth & development; D009154:Mutation; D051381:Rats; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D004254:DNA Nucleotidyltransferases; D019426:Integrases