Human liver alcohol dehydrogenases catalyze the oxidation of the intermediary alcohols of the shunt pathway of mevalonate metabolism.
Human liver alcohol dehydrogenase (ADH) catalyzes the oxidation of 3,3-dimethylallyl alcohol, the intermediary alcohol of the shunt pathway of mevalonate metabolism. ADH isozymes differ in their activities toward this alcohol in the order gamma 1 gamma 1 greater than gamma 2 gamma 2 approximately alfa alfa greater pi pi approximately beta 2 beta 2 approximately beta 1 beta 1 much greater than chi chi; kcat/Km values are 1.4 x 10(8), 1.9 x 10(7), 1.4 x 10(7), 5.6 x 10(6), 3.6 x 10(6), 1.6 x 10(6) and 2.5 x 10(3) M-1 min-1, respectively. The intermediary alcohols geraniol and farnesol of the proposed branch pathways of mevalonate metabolism are also oxidized by these isozymes with similar relative efficiencies. The genetic determinants of ADH isozymes may contribute to the observed differences in serum cholesterol levels among and within various populations.
Keung
W M
WM
Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts.
D000433:1-Propanol / Q000378:metabolism; D000080462:Acyclic Monoterpenes; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D005204:Farnesol / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008798:Mevalonic Acid / Q000378:metabolism*; D010084:Oxidation-Reduction; D020005:Propanols; D013379:Substrate Specificity; D013729:Terpenes / Q000378:metabolism
D000080462:Acyclic Monoterpenes; D007527:Isoenzymes; D020005:Propanols; D013729:Terpenes; C006463:allyl alcohol; D005204:Farnesol; D000433:1-Propanol; D000426:Alcohol Dehydrogenase; C007836:geraniol; D008798:Mevalonic Acid