Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report.
Gastrin-releasing peptide immunoreactivity has been seen in functioning endocrine tumours which are recognized as a major cause of secretory diarrhea. The authors describe a case of a 52-year-old woman who had secretory diarrhea (5 L/d) with markedly elevated gastrin-releasing peptide levels associated with islet cell hyperplasia. No tumour could be identified. The diarrhea was controlled by somatostatin analogue.
Alhindawi
R
R
Department of Surgery, University of Toronto, Ont.
Deitel
M
M
Kempston
J
J
Bendago
M
M
D003967:Diarrhea / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D019886:Gastrin-Releasing Peptide; D006801:Humans; D006965:Hyperplasia; D007279:Injections, Subcutaneous; D007515:Islets of Langerhans / Q000473:pathology*; D008875:Middle Aged; D010452:Peptide Biosynthesis; D010455:Peptides / Q000097:blood*; D013004:Somatostatin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D010455:Peptides; D013004:Somatostatin; D019886:Gastrin-Releasing Peptide