GBR 12909 reverses the SCH 23390 inhibition of rewarding effects of brain stimulation.
Curve-shift was used to test the effect of SCH 23390, a dopamine D1 receptor antagonist, and GBR-12909, a selective dopamine uptake blocker, on self-stimulation behavior. GBR 12909 (8 mg/kg) produced a significant decrease in self-stimulation threshold when administered alone, and reversed the increase in threshold produced by SCH 23390 (0.08 mg/kg). The reversal of the SCH 23390 effect by GBR 12909 suggests that the inhibition of self-stimulation produced by SCH 23390 is due to blockade of dopamine receptors.
Rompré
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PP
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Canada.
Bauco
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D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors*; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000037:antagonists & inhibitors*; D001921:Brain / Q000502:physiology*; D004558:Electric Stimulation; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012201:Reward; D012653:Self Stimulation / Q000187:drug effects*
D014150:Antipsychotic Agents; D001552:Benzazepines; D014179:Neurotransmitter Uptake Inhibitors; D010879:Piperazines; C043425:vanoxerine