Response to suxamethonium in a myasthenic patient during remission.
A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed myasthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08 mg/kg and 0.20 mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90-95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.
Abel
M
M
Department of Anesthesiology, Mount Sinai Medical Center, New York, New York 10029-6574.
Eisenkraft
J B
JB
Patel
N
N
D000758:Anesthesia; D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009157:Myasthenia Gravis / Q000150:complications / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000187:drug effects; D012074:Remission Induction; D013390:Succinylcholine / Q000494:pharmacology*; D014827:Vocal Cords / Q000473:pathology
D013390:Succinylcholine