Development of macromolecular Sn(II) complex for preparation of 99Tcm radiopharmaceuticals.
Macromolecular Sn(II) complex (R-Sn) was developed using a chelating resin containing aminophosphonic acid groups as a reducing agent of 99Tcm(VII) in the preparation of 99Tcm radiopharmaceuticals. Since Sn(II) was bonded strongly to the resin by chelation, release of Sn from R-Sn was rarely observed in saline solution. 99Tcm labelling with a yield greater than 90% was performed by mixing R-Sn, 99Tcm pertechnetate solution and a ligand, such as human serum albumin and diethylenetriamine pentaacetic acid, for a short time. The 99Tcm radiopharmaceuticals were almost free from Sn(II) and the reducing activity of R-Sn was quite stable despite long-term storage without any special care.
Nakayama
M
M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Terahara
T
T
Wada
M
M
Harada
K
K
Sugii
A
A
Hara
M
M
Shimomura
O
O
Kojima
A
A
Tomiguchi
S
S
Izunaga
H
H
D000327:Adsorption; D002614:Chelating Agents; D046911:Macromolecular Substances; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D014001:Tin
D002614:Chelating Agents; D046911:Macromolecular Substances; D013668:Technetium Tc 99m Aggregated Albumin; D014001:Tin; D016284:Technetium Tc 99m Pentetate