title: Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha.
abstract: An 8-year-old boy with subacute sclerosing panencephalitis (SSPE) was treated with 1.0 to 3.0 x 10(6) IU human interferon alpha (IFN) by the intrathecal route weekly or fortnightly. Pronounced improvement of clinical and electroencephalographic findings were observed in a dose-dependent manner. Our patient raises hope that IFN can induce sustained remission in patients with SSPE.
authors.affiliation: Department of Pediatrics, University of Tokushima, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Goda
authors.forename: M
authors.initials: M
authors.lastname: Tayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D002648:Child; D004569:Electroencephalography; D006801:Humans; D007278:Injections, Spinal; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000503:physiopathology / Q000628:therapy*
chemical_list: D007370:Interferon Type I