title: Malignant hyperthermia.
abstract: Malignant hyperthermia (MH) is an acute syndrome that occurs in genetically susceptible persons who have been exposed to certain anesthetic agents. It can also be induced by catecholamines activated by stress. One in 200 people is at risk for developing malignant hyperthermia. The mortality rate may be as high as 15%. A thorough history obtained before surgery is of extreme importance to prevent an MH crisis and in the management of those susceptible to the disorder. If MH is suspected a diagnosis, which can be confirmed by muscle biopsy, should be ruled out before surgery.
authors.forename: D D
authors.initials: DD
authors.lastname: Sinkovich
authors.forename: A E
authors.initials: AE
authors.lastname: Mitch-Resignalo
mesh_terms: D000328:Adult; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000451:nursing* / Q000628:therapy; D008991:Monitoring, Physiologic