title: The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma.
abstract: The suggestion that individuals with the GST1 0 phenotype have a greater susceptibility to carcinogens than those with other GST1 phenotypes has been examined by using a starch gel zymogram approach to compare the frequency of this phenotype in control subjects and a group of patients with adenocarcinoma of stomach and colon. A significantly greater proportion of the patients with adenocarcinoma demonstrated the null phenotype, odds ratio analysis indicating that individuals with this polymorphic variant have an approximately 3-fold greater risk of developing these cancers.
authors.affiliation: School of Postgraduate Medicine and Biological Sciences, University of Keele, North Staffordshire Hospital Centre, Hartshill, Stoke on Trent, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Strange
authors.forename: B
authors.initials: B
authors.lastname: Matharoo
authors.forename: G C
authors.initials: GC
authors.lastname: Faulder
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: W
authors.initials: W
authors.lastname: Cotton
authors.forename: J B
authors.initials: JB
authors.lastname: Elder
authors.forename: M
authors.initials: M
authors.lastname: Deakin
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase