Antibodies to retroviruses of types C and D in female patients with benign and malignant mammary tumours.
The sera of women with benign and malignant mammary tumours were investigated for the presence of antibodies to structural proteins of retroviruses types C and D by indirect immunoenzyme assay (ELISA) and immunoblotting. Among 89 sera tested 5 reacted with the RD-114 protein, 2 with SSV, M-7, and bovine leukaemia virus proteins. None serum reacted with mouse mammary tumour virus proteins. On the basis of these results we conclude that the expression of antibodies to structural retrovirus proteins is not specific for mammary cancer.
Malivanova
T F
TF
All-Union Oncological Centre, U.S.S.R. Academy of Medical Sciences, Moscow.
Litvinov
S V
SV
D000914:Antibodies, Viral / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D001909:Leukemia Virus, Bovine / Q000276:immunology*; D012190:Retroviridae / Q000276:immunology*; D012191:Retroviridae Proteins / Q000276:immunology; D015301:Retroviruses, Simian / Q000276:immunology*; D012842:Sarcoma Virus, Woolly Monkey / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D000914:Antibodies, Viral; D012191:Retroviridae Proteins