Design and synthesis of an opioid receptor probe: mode of binding of S-activated (-)-6 beta-sulfhydryldihydromorphine with the SH group in the mu-opioid receptor.
Kanematsu
K
K
Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Naito
R
R
Shimohigashi
Y
Y
Ohno
M
M
Ogasawara
T
T
Kurono
M
M
Yagi
K
K
D000701:Analgesics, Opioid; D000818:Animals; D004090:Dihydromorphine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D015195:Drug Design; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009022:Morphine Derivatives / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism*; D017450:Receptors, Opioid, mu; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000701:Analgesics, Opioid; D009022:Morphine Derivatives; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D013438:Sulfhydryl Compounds; C065473:6-(5'-nitro-2'-pyridyldithio)deoxydihydromorphine; D004090:Dihydromorphine