Acute neurobehavioural toxicity of phosphamindon and its drug-induced alteration.
Phosphamidon, a systemic organophosphate insecticide, (1.4 mg/kg - dose 1/4th of LD50 given ip), produced several autonomic, neurological and behavioral effects in mice with peak effects being at 15 min. Similar dose in rats also abolished conditioned avoidance response. Pre-treatment with atropine, iproniazid, alpha-methyl-p-tyrosine, p-chlorophenylalanine or thiosemicarbazide reduce many of these effects. This suggests that phosphamidon toxicity involves the central cholinergic, adrenergic, serotonergic and GABAergic systems in addition to peripheral cholinergic effects.
Agarwal
A K
AK
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Sankaranarayanan
A
A
Sharma
P L
PL
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D007490:Iproniazid / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced*; D010707:Phosphamidon / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012663:Semicarbazides / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D012663:Semicarbazides; D010707:Phosphamidon; C005151:thiosemicarbazide; D019805:alpha-Methyltyrosine; D001285:Atropine; D007490:Iproniazid; D014446:Tyrosine 3-Monooxygenase; D010134:Fenclonine