Ischemia decreases the content of the adenine nucleotide translocator in mitochondria of rat kidney.
The activity of the adenine nucleotide translocator is decreased at ischemia. Studies were undertaken to elucidate changes in the adenine nucleotide translocator by determining its content in mitochondria of ischemic rat kidney. After 60 min of ischemia, the content of the adenine nucleotide translocator amounted only to about 55%, of that measured in control mitochondria. At the same time, the flux control coefficient was increased. These changes paralled the well-known effects of ischemia: the decrease in oxidative phosphorylation and in adenine nucleotides. It is supposed that the decrease in the adenine nucleotide translocatar content accounts, at least partially, for the ischemia-induced impairment of mitochondria.
Henke
W
W
Department of Experimental Organ Transplantation, University Hospital Charité, Humboldt University Berlin, F.R.G.
Jung
K
K
D000818:Animals; D007511:Ischemia / Q000201:enzymology*; D007668:Kidney / Q000098:blood supply / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000226:Mitochondrial ADP, ATP Translocases