Synthesis and structure-activity relationship of some new beta-blocking agents with possible alpha-adrenoreceptor activity.
A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non-specific beta- and alpha-adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both beta- and alpha-adrenoreceptors.
Bergmann
J
J
CHINOIN Research Centre, Budapest, Hungary.
Takács
K
K
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D007093:Imidazoles; D011412:Propanolamines; D013890:Thiourea