[Monoamine antagonism in relation to the direct effect of neuroleptics on the release of stimulating amino acid neuromediators].
In the experiments on the superfused synaptosomes of the rat brain cortex it was shown that both typical and atypical neuroleptics in the micromolar range of concentrations decrease K(+)-stimulated 3H-D-aspartate release. Serotonin (10(-5) M) and dopamine (10(-7) M) do not affect D-aspartate release. Serotonin abolishes the action of all typical neuroleptics studied (haloperidol, chlorpromazine, fluphenazine) and of sulpiride and clozapine, but not of carbidine. Dopamine antagonizes only the effect of atypical neuroleptics.
Kovalev
G I
GI
Prikhozhan
A V
AV
Raevskiĭ
K S
KS
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001224:Aspartic Acid / Q000378:metabolism*; D015306:Biogenic Monoamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D014150:Antipsychotic Agents; D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; C028051:neuroleptic receptor; D001224:Aspartic Acid; D011188:Potassium