Energy donor-dependent effect of Cd2+ on [14C]glutamate transport in Staphylococcus aureus.
In starved cells of Cd2(+)-sensitive Staphylococcus aureus 17810S preloaded with either glutamate or pyruvate, [14C]glutamate transport was blocked by 10 microM Cd2+, whereas in cells preloaded with lactate, [14C]glutamate transport was not affected. This differential effect of Cd2+ could be due to the presence or absence of dithiols in the substrate oxidizing systems. In starved cells of Cd2(+)-resistant strain 17810R preloaded with either of the three substrates, [14C]glutamate transport was insensitive to 10 microM Cd2+.
Malm
A
A
Department of Pharmaceutical Microbiology, Medical Academy, Lublin, Poland.
Tynecka
Z
Z
D001692:Biological Transport / Q000187:drug effects; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007700:Kinetics; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D002250:Carbon Radioisotopes; D005971:Glutamates; D002104:Cadmium; D018698:Glutamic Acid