title: Hereditary deficiency of C5 in association with discoid lupus erythematosus.
abstract: A 29-year-old woman with discoid lupus erythematosus had undetectable classic pathway complement activity. Hypocomplementemia was due to selective deficiency of C5. One of her children was also deficient. To our knowledge this is the first documented case of an association between discoid lupus erythematosus and C5 deficiency.
authors.affiliation: Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: S S
authors.initials: SS
authors.lastname: Asghar
authors.forename: G T
authors.initials: GT
authors.lastname: Venneker
authors.forename: M
authors.initials: M
authors.lastname: van Meegen
authors.forename: M M
authors.initials: MM
authors.lastname: Meinardi
authors.forename: R F
authors.initials: RF
authors.lastname: Hulsmans
authors.forename: L P
authors.initials: LP
authors.lastname: de Waal
mesh_terms: D000328:Adult; D003182:Complement C5 / Q000172:deficiency* / Q000235:genetics; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000276:immunology*; D010375:Pedigree
chemical_list: D003182:Complement C5; D006680:HLA Antigens; D003165:Complement System Proteins