title: Quantitative structure-activity relationships of salicylamide neuroleptic agents.
abstract: The in vitro antidopamine activity of substituted N-[(1-alkyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides was found to be well correlated with the hydrophobic and electronic nature of substituents at the 3-position, and with the steric nature of groups replacing the hydrogen atom of the salicyl hydroxy group. In contrast, only the hydrophobic and steric characteristics were found to be important in the in vivo activity of these neuroleptics. This difference suggests that different mechanisms are probably involved in their in vitro and in vivo actions, and that the relevant receptors are slightly different in structure. The in vitro results suggest that electron donation by the 3-substituent strengthens the formation of a hydrogen bond between the carbonyl group of the amide moiety and a hydrogen of the receptor.
authors.affiliation: Birla Institute of Technology and Science, Pilani, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Gupta
authors.forename: R N
authors.initials: RN
authors.lastname: Saha
authors.forename: P
authors.initials: P
authors.lastname: Singh
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000009:adverse effects*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012457:Salicylamides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D011759:Pyrrolidines; D012457:Salicylamides; D004298:Dopamine