[Effects of chorionic gonadotropin (hCG) therapy on the immune system].
Humoral and cellular immunologic parameters were evaluated in 13 prepuberal cryptorchid boys before, during and 3 months after hCG therapy. Before treatment, all the immunologic parameters were normal except for a higher percentage of T suppressor-cytotoxic cells (CD8+). During therapy, the percentage of CD8+ cells and lymphocyte response to ConA significantly decreased, and returned to the control level after hCG withdrawal. The possible effects of long-term hCG treatment on the immune system remains to be determined.
Maghnie
M
M
Clinica Pediatrica, IRCCS Policlinico S. Matteo, Università di Pavia.
Valtorta
A
A
Moretta
A
A
Priora
C
C
Preti
P
P
D002648:Child; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003456:Cryptorchidism / Q000188:drug therapy; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013997:Time Factors
D006063:Chorionic Gonadotropin