title: Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis.
abstract: Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.
authors.forename: A A
authors.initials: AA
authors.lastname: Sinha
authors.forename: R B
authors.initials: RB
authors.lastname: Bell
authors.forename: L
authors.initials: L
authors.lastname: Steinman
authors.forename: H O
authors.initials: HO
authors.lastname: McDevitt
mesh_terms: D000483:Alleles; D001483:Base Sequence; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D015345:Oligonucleotide Probes
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen; D006684:HLA-DR Antigens; D015345:Oligonucleotide Probes