Identification of an autocrine negative growth factor: mouse beta-galactoside-binding protein is a cytostatic factor and cell growth regulator.
Murine beta-galactoside-binding protein, a protein classified as a soluble lectin, is shown to be a cell growth-regulatory molecule and a cytostatic factor. The growth-inhibitory effect is not related to lectin properties, and competition assays indicate that the protein binds to specific cell surface receptors with high affinity. It exerts control in G0 and at G2, both as a regulator of cell replication and as a cytostatic factor.
Wells
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V
Division of Microbiology, United Medical School, Guy's Hospital, London Bridge, England.
Mallucci
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L
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D002478:Cells, Cultured; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D005690:Galactose / Q000378:metabolism*; D015723:Gene Library; D006133:Growth Substances / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins; D010446:Peptide Fragments / Q000302:isolation & purification; D033902:Periplasmic Binding Proteins; D011994:Recombinant Proteins / Q000302:isolation & purification / Q000378:metabolism
D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D006133:Growth Substances; D009004:Monosaccharide Transport Proteins; D010446:Peptide Fragments; D033902:Periplasmic Binding Proteins; D011994:Recombinant Proteins; C023550:galactose-binding protein; D004247:DNA; D005690:Galactose