Midazolam-induced benzodiazepine withdrawal syndrome.
A case history of a patient who developed severe anxiety and agitation on two occasions after discontinuation of a midazolam infusion is presented. The withdrawal symptoms interfered with effective mechanical ventilation and the patient required the reintroduction of a long-acting benzodiazepine to treat the withdrawal state and to facilitate weaning from mechanical ventilation.
Mets
B
B
Respiratory Intensive Care Unit, University of Cape Town, Observatory, South Africa.
Horsell
A
A
Linton
D M
DM
D017109:Akathisia, Drug-Induced; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008874:Midazolam / Q000009:adverse effects*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013997:Time Factors; D015300:Ventilator Weaning
D008874:Midazolam