Relaxant and beta 2-adrenoceptor blocking activities of (+/- )-, (+)- and (-)-pindolol on the rat isolated aorta.
The KCl contracted rat aorta is relaxed by procaterol, (+/- )-, (+)- and (-)-pindolol. The relaxations to procaterol, but not to (+/- )-pindolol, were prevented by ICI 118,551 at 10(-6) M. The relaxations to (+/- )-pindolol are, therefore, not due to beta-adrenoceptor agonism. At 10(-7) M ICI 118,551, (+/- )-, (+)- and (-)-pindolol were beta 2-adrenoceptor antagonists as they inhibited the relaxant responses of the aorta to procaterol.
Doggrell
S A
SA
Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.
D000319:Adrenergic beta-Antagonists; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010869:Pindolol / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D017265:Procaterol; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D011412:Propanolamines; C026777:ICI 118551; D011189:Potassium Chloride; D010869:Pindolol; D017265:Procaterol