Stimulation of both D1 and D2 dopamine receptors increases behavioral activation and ascorbate release in the neostriatum of freely moving rats.
Electrochemically modified carbon-fiber electrodes were used to assess the effects of indirect (amphetamine and GBR-12909) as well as direct D1 (SKF-38393) and D2 (quinpirole) dopamine agonists on extracellular ascorbate in the neostriatum of awake, behaving rats. Relative to controls, 2.5 mg/kg d-amphetamine and 20.0 mg/kg GBR-12909 produced marked behavioral activation concomitant with a significant increase in ascorbate. Comparable effects were observed following the combined administration of 10.0 mg/kg SKF-38393 and 1.0 mg/kg quinpirole, but not after either of these drugs alone. Thus, behavioral activation and release of neostriatal ascorbate were closely related to the concurrent stimulation of both D1 and D2 dopamine receptors.
Pierce
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Department of Psychology, Indiana University, Bloomington 47405.
Rebec
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GV
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology; D004563:Electrochemistry; D004566:Electrodes; D004873:Ergolines / Q000494:pharmacology; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013238:Stereotaxic Techniques; D013268:Stimulation, Chemical
D015259:Dopamine Agents; D004873:Ergolines; D014179:Neurotransmitter Uptake Inhibitors; D010879:Piperazines; D011954:Receptors, Dopamine; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; C043425:vanoxerine; D000661:Amphetamine; D001205:Ascorbic Acid