title: A marine mollusc provides the first example of in vivo storage of prostaglandins: prostaglandin-1,15-lactones.
abstract: Prostaglandin-(PG) 1,15-lactones and, in smaller amounts, free acids, were isolated from both the mantle and the dorso-lateral appendices of the opisthobranch mollusc Tethys fimbria. In vivo conversion of PGs into the corresponding lactones and accumulation of PGE2- and PGE3-1,15-lactones in the appendages were shown. The detachment of these appendages from the molested mollusc caused the in vivo conversion of PGE2- and PGE3-lactones back to PGE2 and PGE3 respectively, thus providing the first example of a mechanism by which prostaglandins can be stored and, when needed, released.
authors.affiliation: Istituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cimino
authors.forename: A
authors.initials: A
authors.lastname: Crispino
authors.forename: V
authors.initials: V
authors.lastname: Di Marzo
authors.forename: G
authors.initials: G
authors.lastname: Sodano
authors.forename: A
authors.initials: A
authors.lastname: Spinella
authors.forename: G
authors.initials: G
authors.lastname: Villani
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D007783:Lactones / Q000302:isolation & purification / Q000378:metabolism*; D008974:Mollusca / Q000378:metabolism*; D011453:Prostaglandins / Q000302:isolation & purification / Q000378:metabolism*; D011865:Radioisotope Dilution Technique; D013056:Spectrophotometry, Ultraviolet; D014316:Tritium
chemical_list: D007783:Lactones; D011453:Prostaglandins; D014316:Tritium