title: Effect of dibutyltin dilaurate on regional brain polyamines in rats.
abstract: Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.
authors.affiliation: Industrial Toxicology Research Center, Lucknow, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Khaliq
authors.forename: R
authors.initials: R
authors.lastname: Husain
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
authors.forename: S P
authors.initials: SP
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D009947:Organotin Compounds; D013096:Spermine; C010409:dibutyltin dilaurate; D013095:Spermidine