Somatostatin release induced by gastrin-releasing peptide in man. Effect of proximal gastric vagotomy and cholinergic blockade.
The influence of intragastric pH on the basal release of somatostatin has been studied in healthy controls and in duodenal ulcer patients. In addition the somatostatin response to gastrin-releasing peptide infusion has been evaluated both regarding the effect of intragastric pH and the influence of vagal innervation and muscarinic blockade. No difference was found in basal blood levels, when changing the intraluminal pH, although a slightly higher basal somatostatin concentration was noticed in patients with duodenal ulcer disease. Neither proximal gastric vagotomy nor cholinergic blockade had any effect on basal somatostatin concentrations. GRP infused in stepwise increasing doses from 20 pmol/kg/h to 400 pmol/kg/h induced a small but significant response. This effect of GRP was most evident, when the stomach was perfused with 0.1 M HCl. The small, somatostatin response to GRP infusion was not influenced by vagal denervation of the parietal cell area, neither by cholinergic blockade. Despite the previously observed effects of vagotomy and cholinergic blockade on gastrin release induced by GRP, a corresponding inverse effect on somatostatin is not apparent.
Sjövall
M
M
Department of Surgery, Sahlgren's Hospital, University of Gothenburg, Sweden.
Holst
J J
JJ
Olbe
L
L
Lundell
L
L
D000328:Adult; D004381:Duodenal Ulcer / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D019886:Gastrin-Releasing Peptide; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000494:pharmacology* / Q000627:therapeutic use; D010455:Peptides / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use; D013004:Somatostatin / Q000097:blood*; D014629:Vagotomy, Proximal Gastric
D010276:Parasympatholytics; D010455:Peptides; D011759:Pyrrolidines; D013004:Somatostatin; D019886:Gastrin-Releasing Peptide; C004460:benzilonium bromide