MIF-1 can accelerate neuromotor, EEG and behavioral development in mice.
Newborn mice were injected SC daily with 1 mg/kg of MIF-1 or saline during the first 19 days of life. The progress of each pup was monitored for physical (body weight, eye and ear opening), neurobehavioral (reflexes) and neurophysiological (EEG) development until the weaning stage. In early adulthood (40 days of age) mice were tested on a maze learning task. Results indicate that MIF-1 can accelerate neurologic (days 3-9), somatic (days 10-14) and electroencephalographic (days 16-19) parameters, and that the effects of treatment last into the early adult stage with increased learning abilities in an appetitive task.
d'Amore
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Istituto Superiore di Sanità, Roma, Italy.
Pieretti
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S
Palazzesi
S
S
Pezzini
G
G
Chiarotti
F
F
Scorza
T
T
Loizzo
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D007858:Learning / Q000187:drug effects; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D009043:Motor Activity / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted
D009075:MSH Release-Inhibiting Hormone