[The effect of liposomes on the hormonal induction of liver tyrosine aminotransferase in an experiment].
Liposomes prevented the hydrocortisone-produced induction of tyrosine aminotransferase in animal liver tissue under conditions of normal state and of alcohol intoxication. The inhibitory effect of liposomes appears to be mainly based on their ability to incorporate into hepatocyte membranes, due to which the membrane permeability towards hydrocortisone was altered.
Galaev
Iu V
IuV
Zakrevskiĭ
V I
VI
Goncharova
L V
LV
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006854:Hydrocortisone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008081:Liposomes / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D008081:Liposomes; D008563:Membrane Lipids; D000431:Ethanol; D014444:Tyrosine Transaminase; D006854:Hydrocortisone