[The role of carrier ATPases and neuromediators in neurological disorders].
Physiological and biochemical processes which take place in the nervous system at stroke and neurotrauma are reviewed, and the experience of using low doses of steroid derivatives with piridamole in the treatment of central nervous system (CNS) disorders is summarized. ATPases (including Na,K-ATPase) are reported to play an important role in CNS functioning, the correlation between Na,K-ATPase activity and the extent of CNS injury is revealed. The use of NMR-spectroscopy method for investigation of brain and spinal cord condition in vivo is suggested.
Lombardi
V
V
Capuano
F
F
Coci
A
A
Broun
T R
TR
Graham
R
R
D000251:Adenosine Triphosphatases / Q000032:analysis / Q000502:physiology*; D000777:Anesthetics / Q000633:toxicity; D000818:Animals; D001369:Axons / Q000201:enzymology; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D001923:Brain Chemistry; D002352:Carrier Proteins; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals; D009682:Magnetic Resonance Spectroscopy; D009422:Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D018377:Neurotransmitter Agents / Q000032:analysis / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000737:chemistry
D000777:Anesthetics; D002352:Carrier Proteins; D005609:Free Radicals; D018377:Neurotransmitter Agents; D000251:Adenosine Triphosphatases