title: Changes in thyroglobulin release-stimulating activity (Tg-RSA) in immunoglobulin G from patients with Graves' disease during therapy with thionamide drug.
abstract: We have reported previously a new method for detecting thyroglobulin release stimulating activity (Tg-RSA) by human thyroid monolayer cells in IgGs from Graves' patients. We report here changes in Tg-RSA in sera of patients during treatment with thionamide drug. Nineteen untreated patients had their Tg-RSA, TSAb, TBII and serum Tg concentration (STg) followed up. Before treatment, Tg-RSA and TSAb were positive in all 19 patients. Three of them were TBII negative. During treatment with thionamide, of 16 patients who had positive Tg-RSA, TSAb and TBII before treatment, 6 patients continued so during the period of observation. Of the remaining 10 patients, 8 became TBII negative. TSAb only was found negative in one patient and Tg-RSA only declined to negative in another patient. Three patients whose TBII was initially negative, were observed to be negative in all three indicators after treatment. STg was higher than normal in all patients before therapy and changes in Tg-RSA in almost all patients were parallel with those in STg during treatment. From the observation during treatment with thionamide, our results suggest that Tg-RSA in Graves' patients appears to have similar properties to TSAb.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Fukue
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: F
authors.initials: F
authors.lastname: Takaku
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaji
authors.forename: H
authors.initials: H
authors.lastname: Uchimura
mesh_terms: D000577:Amides / Q000494:pharmacology*; D001323:Autoantibodies; D002478:Cells, Cultured; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D018828:Immunoglobulins, Thyroid-Stimulating; D013854:Thioamides / Q000494:pharmacology*; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism
chemical_list: D000577:Amides; D001323:Autoantibodies; D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D013854:Thioamides; D013954:Thyroglobulin