title: Comparative study of the edema-inducing activity of snake venoms.
abstract: 1. The edema-inducing activity of 24 venoms from snakes of the subfamilies of Elapinae, Hydrophiini, Crotalinae and Viperinae was determined. 2. All snake venoms tested are very potent edema inducers. The minimum edema doses of the venoms ranged from 0.16 to 3.41 micrograms per mouse paw. 3. The venoms induced a rapid onset edema which peaked within 1 h of injection and declined thereafter; at low dose, however, some venoms induced a rapid onset edema that sustained over a longer duration.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: M N
authors.initials: MN
authors.lastname: Saifuddin
mesh_terms: D000818:Animals; D003435:Crotalid Venoms / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced*; D004546:Elapid Venoms / Q000008:administration & dosage / Q000633:toxicity; D007700:Kinetics; D051379:Mice; D012910:Snake Venoms / Q000008:administration & dosage / Q000633:toxicity*; D014757:Viper Venoms / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D003435:Crotalid Venoms; D004546:Elapid Venoms; D012910:Snake Venoms; D014757:Viper Venoms