A case report of cimetidine-induced clozapine toxicity.
Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.
Szymanski
S
S
Psychiatric Research Department, Hillside Hospital, Glen Oaks, NY 11004.
Lieberman
J A
JA
Picou
D
D
Masiar
S
S
Cooper
T
T
D000328:Adult; D002908:Chronic Disease; D002927:Cimetidine / Q000009:adverse effects* / Q000494:pharmacology; D003024:Clozapine / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000493:pharmacokinetics / Q000627:therapeutic use; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000523:psychology
D002927:Cimetidine; D011899:Ranitidine; D003024:Clozapine