Assignment of the polymorphic intestinal mucin gene (MUC2) to chromosome 11p15.
A cDNA coding for a mucin expressed in intestine has recently been cloned (Gum et al. 1989). We describe here the use of this cDNA to map the gene (MUC2) to human chromosome 11 using somatic cell hybrids, and to make the regional localization to 11p15 by in situ hybridization. Analysis of the CEPH (Centre d'Etude du Polymorphisme Humain) families revealed that MUC2 forms part of the tight linkage group on 11p15 which contains HRAS, INS, TH and HBBC.
Griffiths
B
B
MRC Human Biochemical Genetics Unit, University College London.
Matthews
D J
DJ
West
L
L
Attwood
J
J
Povey
S
S
Swallow
D M
DM
Gum
J R
JR
Kim
Y S
YS
D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D007422:Intestines / Q000737:chemistry*; D008297:Male; D051379:Mice; D009077:Mucins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D009077:Mucins