title: Susceptibility of mammalian, avian, fish, and mosquito cell lines to rabies virus infection.
abstract: The relationship between plasma membrane receptor organization and cell susceptibility in vitro was investigated in mammalian, avian, fish, and arthropod cell lines infected with fixed rabies virus. IMR32, HeLa, CER, and EPC cells were widely susceptible to infection with CVS virus, whereas a lower level of specific viral antigens was detectable in A. albopictus cells. In spite of these differences, the amount of infectious virus particles bound to the various cell surfaces was similar. Competition experiments carried out with plasma membranes extracted from ability of these components to bind the virus and to prevent infection. The different cellular permissiveness to rabies infection described here did not correlate with significant differences in number or in chemical structure of the receptor binding sites, but more likely with events following virus adsorption.
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina, Università La Sapienza, Roma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Seganti
authors.forename: F
authors.initials: F
authors.lastname: Superti
authors.forename: S
authors.initials: S
authors.lastname: Bianchi
authors.forename: N
authors.initials: N
authors.lastname: Orsi
authors.forename: M
authors.initials: M
authors.lastname: Divizia
authors.forename: A
authors.initials: A
authors.lastname: Panà
mesh_terms: D000327:Adsorption; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001287:Attachment Sites, Microbiological; D001667:Binding, Competitive; D001717:Birds; D002460:Cell Line / Q000382:microbiology*; D002462:Cell Membrane / Q000276:immunology; D009033:Culicidae; D005399:Fishes; D006801:Humans; D011820:Rabies virus / Q000254:growth & development*; D011991:Receptors, Virus / Q000276:immunology; D014162:Transfection; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D011991:Receptors, Virus