[Changes in the sensitivity of the central nervous system to fenazepam at different stages of the recovery period after systemic circulatory arrest in rats].
Chronic experiments were conducted on rats subjected to 10-minute circulatory arrest to study the effect of intraperitoneal phenazepam (2 mg/kg) injection in various periods after resuscitation on some behavior indices. It was found that the changes in the quantitative (the degree of the effect) and qualitative (the extent of the effect) manifestations of the tranquilizing effect of phenazepam were determined by the different stages of restoration (from 1 to 21 days) after resuscitation. The results provide evidence of a definite stage character in the reactivity of the central nervous system in relation to pharmacological effects after resuscitation and, possibly, may reflect the functional reorganization of the work of the receptor complex and ion conductivity in the postresuscitation period.
Mutuskina
E A
EA
Garibova
T L
TL
Gurvich
A M
AM
Voronina
T A
TA
D000758:Anesthesia; D000762:Anesthesia Recovery Period; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004986:Ether; D006324:Heart Arrest, Induced; D008297:Male; D051381:Rats; D012151:Resuscitation; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D004986:Ether; D001569:Benzodiazepines; C017928:phenazepam