Surface anesthetic effect and subjective compatibility of 2% carteolol and 0.6% metipranolol in eye-healthy people.
In a placebo-controlled, randomized, prospective, parallel, double-masked trail we study corneal sensitivity before and after application of 2% carteolol (20 eyes) and 0.6% metipranolol (20 eyes). 2% carteolol does not decrease corneal sensitivity (no significant difference to the placebo group). 0.6% metipranolol leads to a decrease of corneal sensitivity up to 14 mg/S (median), lasting up to 15 minutes. The local anesthetic effect is an important parameter for the subjective compatibility.
Höh
H
H
Department of Ophthalmology, University of Saarland, Homburg, FRG.
D000772:Anesthesia, Local; D002354:Carteolol / Q000008:administration & dosage*; D003315:Cornea / Q000187:drug effects* / Q000503:physiopathology; D004311:Double-Blind Method; D006801:Humans; D014290:Metipranolol / Q000008:administration & dosage*; D010919:Placebos; D011446:Prospective Studies
D010919:Placebos; D002354:Carteolol; D014290:Metipranolol