Efficacy of low doses of praziquantel in taeniasis.
Early experimental studies suggested that doses of 1 to 5 mg of praziquantel (PZQ) per kg are effective against several intestinal cestodiases. The usually recommended single dose of PZQ in human taeniasis is 5 or 10 mg/kg. A study in T. saginata taeniasis showed a full efficacy at a dose of 2.5 mg/kg. A field study confirmed that a dose between 3.4 and 7.5 mg/kg was effective in expulsion T. solium tapeworms in man. A dose of 2.5 mg of PZQ per kg would be safer and more economical in population-oriented interventions aiming at control of T. solium taeniasis in man.
Pawłowski
Z S
ZS
Clinic of Parasitic and Tropical Diseases, Academy of Medicine, Poznan, Poland.
D000818:Animals; D006801:Humans; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D013622:Taeniasis / Q000188:drug therapy*
D011223:Praziquantel