title: Systemic to pulmonary bronchial blood flow in mitral stenosis.
abstract: We measured systemic to pulmonary bronchial blood flow [Qbr(s-p)] during total cardiopulmonary bypass in 15 patients with mitral stenosis and elevated pulmonary venous pressure (group A, mean pulmonary wedge pressure = 22.2 +/- 5.4 mm Hg, mean +/- SD) and in 15 patients with coronary artery diseases and normal pulmonary venous pressure (group B). Qbr(s-p) is the volume of blood accumulating in the left side of the heart in the absence of pulmonary and coronary flows. This blood was vented through a cannula introduced into the left atrium and measured. Qbr(s-p) was 76.3 +/- 13.9 ml/min (2.18 +/- 0.37 percent of extracorporeal circulation pump flow) and 22.3 +/- 2.1 (0.63 +/- 0.15) in group A and B, respectively (p less than 0.01). During total cardiopulmonary bypass, pulmonary venous pressure is approximately atmospheric pressure, and no differences in systemic blood pressure, extracorporeal circulation pump flow, and airways pressure were observed between group A and B. Therefore, vascular resistance through the bronchial vessels draining into the pulmonary circulation is reduced in patients with mitral stenosis and elevated pulmonary venous pressure.
authors.affiliation: Istituto di Cardiologia, Università di Milano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Agostoni
authors.forename: M
authors.initials: M
authors.lastname: Agrifoglio
authors.forename: V
authors.initials: V
authors.lastname: Arena
authors.forename: E
authors.initials: E
authors.lastname: Doria
authors.forename: A
authors.initials: A
authors.lastname: Sala
authors.forename: G
authors.initials: G
authors.lastname: Susini
mesh_terms: D000328:Adult; D000368:Aged; D001775:Blood Circulation / Q000502:physiology*; D001831:Body Temperature; D001980:Bronchi / Q000098:blood supply*; D002302:Cardiac Output; D002315:Cardiopulmonary Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000503:physiopathology* / Q000601:surgery; D011652:Pulmonary Circulation / Q000502:physiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012039:Regional Blood Flow; D014690:Venous Pressure / Q000502:physiology