Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I.
The effect of insulin-like growth factor I (IGF-I) on renal blood flow was measured in the anaesthetized rat using an electromagnetic flow probe. Renal vasodilation induced by IGF-I (50 micrograms/kg) was completely inhibited by NG-nitro-l-arginine methyl ester (50 mg/kg), an inhibitor of nitric oxide biosynthesis, but only partially reduced by indomethacin (10 mg/kg). The involvement of nitric oxide synthesis in the renal actions of IGF-I is proposed.
Haylor
J
J
Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, England, United Kingdom.
Singh
I
I
el Nahas
A M
AM
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D009569:Nitric Oxide; D007334:Insulin-Like Growth Factor I; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester; D007213:Indomethacin