title: Cooperative B-Z transition of poly(dG-dC) induced by spermine at physiological temperature in aqueous medium.
abstract: Spermine induced B-Z transition of poly(dG-dC) in aqueous medium at and above physiological temperature, at cellular concentration levels in low ionic strength medium. The amine to phosphate ratio, A/P, at the midpoint of the transition decreases with increase in temperature. The enthalpy change was 45 +/- 8 kcal per mol of cooperative unit; the transition induced by spermine is highly cooperative with a cooperative unit length of 700 +/- 20 at 50 degrees C.
authors.affiliation: Department of Chemistry, University of Delhi, India.
authors.forename: M V
authors.initials: MV
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Atreyi
authors.forename: S
authors.initials: S
authors.lastname: Saxena
mesh_terms: D002942:Circular Dichroism; D009994:Osmolar Concentration; D011089:Polydeoxyribonucleotides / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013096:Spermine / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D013816:Thermodynamics; D014867:Water
chemical_list: D011089:Polydeoxyribonucleotides; D014867:Water; C019530:poly(dC-dG); D013096:Spermine