title: Systemic fluconazole therapy and in vitro adhesion of Candida albicans to human buccal epithelial cells.
abstract: The adhesion of Candida albicans to buccal epithelial cells (BEC) from four healthy dentate men was studied in vitro 1 wk before, during and after a course of systemic fluconazole (50 mg once daily for 1 wk). After 1 wk of fluconazole intake candidal adhesion to BEC was significantly reduced and this reduction persisted for a week following completion of therapy. Fluconazole, therefore, in addition to being an effective antifungal agent may also have a sustained action on reducing adherence of candidal species to the oral mucosa.
authors.affiliation: Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School, Scotland.
authors.forename: A M
authors.initials: AM
authors.lastname: Darwazeh
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamey
authors.forename: M A
authors.initials: MA
authors.lastname: Lewis
authors.forename: L P
authors.initials: LP
authors.lastname: Samaranayake
mesh_terms: D000328:Adult; D002176:Candida albicans / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004847:Epithelial Cells; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology*; D013997:Time Factors
chemical_list: D015725:Fluconazole