Hemiepiphyseal reconstruction using tissue donated from fetal limbs in a murine model.
Epiphyseal reconstruction in the immature skeleton could have great clinical significance. Hemiepiphyseal reconstruction was performed in a murine model by transplanting fetal tissue to surgically created defects in postnatal mice. Reconstruction is facilitated by the existence of inbred strains. While the reconstruction as performed here did not completely restore the growth characteristics of the epiphysis, the model represents a potentially fruitful interface between basic and clinical biology.
Wolohan
M J
MJ
Department of Orthopaedics, Massachusetts General Hospital, Boston 02114.
Zaleske
D J
DJ
D000818:Animals; D004838:Epiphyses / Q000473:pathology / Q000601:surgery*; D005121:Extremities / Q000637:transplantation; D005269:Femur / Q000601:surgery; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL