title: [Asthma and gastroesophageal reflux. Outcome of asthma after longterm medical treatment of the reflux].
abstract: Over one half of the cases of chronic severe childhood asthma, refractory to conventional therapy and without other over aetiology, are associated to gastroesophageal reflux (GER). The aetiopathogenic role of GER in asthma is uncertain, and is only confirmed when therapy of the former induces evident improvement of the latter. We have instituted medical antireflux therapy over two years in 17 patients (17.6%) became asymptomatic after less than three months of therapy, and a further four (23.5%) by the sixth month. Seven patients showed clinical improvement by the third month (41%) and even a greater one by the sixth month, only very slight symptoms persisting thereafter. In three cases (17.6%) there was no improvement after two years of outcome of asthma and the persistence or not of pathological between the outcome of asthma and the persistence or not of pathological 24-hour pHmetry. On the contrary. macroscopic oesophagitis disappeared in the cases of asthma with good outcome, but persisted in all the cases who remained symptomatic. In conclusion, we consider that medical management of GER associated to asthma should be maintained for at least six months (if the clinical course so permits) before considering a surgical indication.
authors.affiliation: Hospital Infantil La Paz, Madrid.
authors.forename: J A
authors.initials: JA
authors.lastname: Ojeda Casas
authors.forename: M C
authors.initials: MC
authors.lastname: García Ara
authors.forename: F
authors.initials: F
authors.lastname: Martín Muñoz
authors.forename: J M
authors.initials: JM
authors.lastname: Díaz Pena
authors.forename: B
authors.initials: B
authors.lastname: Añibarro Bausera
authors.forename: H
authors.initials: H
authors.lastname: Escobar Castro
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000627:therapeutic use; D004941:Esophagitis / Q000150:complications / Q000188:drug therapy; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D013806:Theophylline / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D013806:Theophylline