Na(+)-dependent Ca2+ influx in bovine adrenal chromaffin cells.
Bovine adrenal chromaffin cells were loaded with Na+ via either acetylcholine receptor-associated ion channels or voltage-sensitive Na+ channels. There were increases in [Ca2+]i, 45Ca2+ uptake and catecholamine secretion in both types of Na(+)-loaded cells relative to control cells in which Na+ loading had been prevented by hexamethonium and tetrodotoxin, respectively. These results show the presence of Na(+)-dependent Ca2+ influx activity in chromaffin cells which is probably mediated by the reverse mode of a Na+/Ca2+ exchanger.
Liu
P S
PS
Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China.
Kao
L S
LS
D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D004553:Electric Conductivity; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007700:Kinetics; D011950:Receptors, Cholinergic / Q000378:metabolism; D012964:Sodium / Q000378:metabolism* / Q000494:pharmacology; D015222:Sodium Channels / Q000378:metabolism; D019831:Sodium-Calcium Exchanger; D013779:Tetrodotoxin / Q000494:pharmacology
D002352:Carrier Proteins; D002395:Catecholamines; D006584:Hexamethonium Compounds; D011950:Receptors, Cholinergic; D015222:Sodium Channels; D019831:Sodium-Calcium Exchanger; D018738:Hexamethonium; D013779:Tetrodotoxin; D012964:Sodium; D002118:Calcium