Renal responses to magnesium lithospermate B.
Renal responses to magnesium lithospermate B isolated from Salviae miltiorrhizae radix were examined in normal rats. Urinary sodium, potassium, prostaglandin E2 and kallikrein excretion was significantly increased after magnesium lithospermate B administration, whereas excretion of urinary 6-keto-prostaglandin F1 alpha and thromboxane B2 was unchanged. Rats administered with the drug also revealed a slight elevation of plasma renin activity and the levels of angiotensins I and II. Plasma aldosterone was decreased slightly. No significant changes were observed in angiotensin-converting enzyme or blood pressure.
Yokozawa
T
T
Department of Applied Biochemistry, Toyama Medical and Pharmaceutical University, Japan.
Lee
T W
TW
Chung
H Y
HY
Oura
H
H
Nonaka
G
G
Nishioka
I
I
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine; D006728:Hormones / Q000097:blood; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D014563:Urodynamics / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D004573:Electrolytes; D006728:Hormones; D011453:Prostaglandins; C061091:lithospermate B; D007610:Kallikreins