Induction and upregulation of adhesion receptors in oral and dermal lichen planus.
The expression pattern of well-defined cell surface adhesion receptors called VLA-family, LFA-1 and ICAM-1 was determined semiquantitatively in biopsies of oral (n = 12) and dermal lichen planus (n = 5) and compared to normal uninvolved human oral mucosa (n = 12) and skin (n = 12) using an indirect immunoperoxidase technique. In both oral and dermal lichen planus, an induction of the beta 1-integrins VLA-1 and VLA-3 and an upregulation of VLA-6 was found in T cells infiltrating the basement membrane zone. These cell surface molecules function as receptors for collagen, fibronectin and laminin. A focal induction of ICAM-1 on basal keratinocytes could be detected at sites of intramucosal T cells. These results suggest that investigated adhesion receptors are crucially involved in the aggregation of T cells in both conditions. Further investigations have to be done to determine the functional role of these adhesion receptors in lichen planus.
Konter
U
U
Department of Maxillofacial Surgery, University of Kiel, Germany.
Kellner
I
I
Hoffmeister
B
B
Sterry
W
W
D015703:Antigens, CD / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D004727:Endothelium / Q000473:pathology; D005347:Fibroblasts / Q000737:chemistry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D015603:Keratinocytes / Q000737:chemistry; D007801:Langerhans Cells / Q000737:chemistry; D008010:Lichen Planus / Q000378:metabolism* / Q000473:pathology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis*; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000737:chemistry; D016029:Receptors, Very Late Antigen / Q000032:analysis*; D011991:Receptors, Virus / Q000032:analysis*; D012867:Skin / Q000737:chemistry; D013601:T-Lymphocytes / Q000737:chemistry
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D016029:Receptors, Very Late Antigen; D011991:Receptors, Virus; D018799:Intercellular Adhesion Molecule-1