[Atopic dermatitis: role of oxatomide].
Oxatomide is an antiallergic molecule which acts mainly as a calcium blocker. This article is a review of oxatomide treatment in atopic dermatitis patients. First, an overview of oxatomide treatment hypersensitivity reactions in atopic dermatitis and of their supposed immunologic mechanisms. The total number of patients treated so far in published studies is too low to fully appreciate the therapeutic benefit of this molecule. However, encouraging results were reported in two controlled studies and 3 open studies originating from four different groups. Tolerance was excellent (of 200 patients evaluated in 5 studies, transient sleepiness was noted in 5, and weight gain was noted in 3 children).
Taieb
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Service de Dermatologie, Hôpital des Enfants, Bordeaux.
D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D010879:Piperazines / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D010879:Piperazines; D007073:Immunoglobulin E; C015408:oxatomide