title: [Chemotherapy of skin and soft tissue tumors].
abstract: Systemic chemotherapy may be used in locally advanced or metastatic soft tissue sarcoma for palliation. Malignant melanoma shows objective responses in about 20% of patients treated with chemotherapy or with cytokines (IL-2, alpha-IFN). Adjuvant chemotherapy has not proven to be effective in either of these entities. The risk of local recurrences in limbs however can be reduced by hyperthermic perfusion with cytotoxic agents. Neoadjuvant (preoperative) treatment of locally advanced tumors needs to be prospectively evaluated. Symptomatic Kaposi sarcoma can be effectively treated with alpha-IFN or chemotherapy.
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum Rudolf Virchow, Freien Universität, Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000601:surgery; D008545:Melanoma / Q000188:drug therapy / Q000601:surgery; D011379:Prognosis; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000601:surgery; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents