Bgl II-restriction fragment length polymorphism of the insulin receptor gene in patients with type-II diabetes mellitus.
As an approach to estimate the involvement of the insulin receptor gene in the etiopathogenesis of type-II diabetes mellitus we determined the distribution of the alleles of a restriction fragment length polymorphism of this gene (Bgl II-RFLP) in a group of type-II diabetics. The patients had been characterized by insulin and C-peptide values during OGTT and insulin receptor binding indices. The difference in allelic distribution to a healthy control group (10% "+"-allele in diabetics versus 18% in control persons), was not significant in chi 2-analysis.
Menzel
S
S
Institute of Biochemistry, School of Medicine, Ernst Moritz Arndt University, Greifswald, FRG.
Neumer
C
C
Zorad
S
S
Klimes
I
I
Langerova
H
H
Zühlke
H
H
D000483:Alleles; D001426:Bacterial Proteins; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011972:Receptor, Insulin / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins; D015342:DNA Probes; D011972:Receptor, Insulin; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific