title: Tolerability and pharmacokinetics of remoxipride after intramuscular administration.
abstract: A study was undertaken in seven schizophrenic patients to evaluate the tolerability and examine the pharmacokinetics of intramuscularly administered remoxipride after a single 200 mg dose and at steady state following repeated doses of 200 mg twice daily for one week. Comparisons of AUC, t1/2 and tmax using the Wilcoxon's signed rank test showed no significant difference between single dose and steady state indicating that the pharmacokinetics of intramuscular remoxipride were linear. The steady-state Cmax was found to be significantly larger than that after single dose and the increase was accounted for by the predicted accumulation factor, assuming linear kinetics. Although the inter-individual variability in plasma concentrations was large, the intra-individual variability was low as shown by the reproducibility of the single-dose and steady-state plasma curves. Remoxipride, administered intramuscularly, was well tolerated.
authors.affiliation: Centre Hospitalier Regional de Nancy, Psychologie Medicale et Psychotherapie Hôpital Jeanne D'Arc, Toul, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Kahn
authors.forename: W
authors.initials: W
authors.lastname: Yisak
authors.forename: C
authors.initials: C
authors.lastname: Albaret
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Zaar-Hedin
authors.forename: M
authors.initials: M
authors.lastname: Laxenaire
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D001549:Benzamides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D017330:Remoxipride; D012559:Schizophrenia / Q000097:blood*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides; D017330:Remoxipride