title: Heterogeneity of presynaptic serotonin receptors on sympathetic neurones in blood vessels.
abstract: Presynaptic serotonin (5-HT) receptors on the postganglionic sympathetic nerves, which mediate inhibition of noradrenaline release in blood vessels of various species and which interact with the presynaptic alpha 2-autoreceptors, are heterogeneous. In the rat vena cava, they are of the 5-HT1B subtype, in the pig coronary artery they belong to a novel, so far unknown class of 5-HT receptors, and in the human saphenous vein they could be classified as 5-HT1D. These results point to marked species differences and the need to carry out experiments in human vascular preparations. Presynaptic 5-HT receptors may be involved in the mechanism of action of the new antimigraine drug sumatriptan.
authors.affiliation: Institute of Pharmacology and Toxicology, University of Bonn, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Göthert
authors.forename: G J
authors.initials: GJ
authors.lastname: Molderings
authors.forename: K
authors.initials: K
authors.lastname: Fink
authors.forename: E
authors.initials: E
authors.lastname: Schlicker
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D003331:Coronary Vessels / Q000294:innervation; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012501:Saphenous Vein / Q000294:innervation; D013552:Swine; D013564:Sympathetic Nervous System / Q000378:metabolism*; D014684:Venae Cavae / Q000294:innervation
chemical_list: D011985:Receptors, Serotonin; D009638:Norepinephrine