New strategy for discovery of enzyme inhibitors: screening with intact mammalian cells or intact microorganisms having special functions.
Tomoda
H
H
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Omura
S
S
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005493:Folic Acid Antagonists / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D005974:Glutamate-Ammonia Ligase / Q000037:antagonists & inhibitors; D006801:Humans; D050356:Lipid Metabolism; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011493:Protein Kinase C; D005974:Glutamate-Ammonia Ligase