title: Carbohydrates as recognition molecules for bacterial adhesins: methodology and characteristics.
abstract: Future attempts at developing inhibitors of dental plaque formation necessitate characterization of the bacterial-host, as well as the inter-bacterial recognition processes. Bacterial binding to a panel of solid-phase reference glycolipids was used to reveal the recognition of internal receptor sequences, low-affinity cooperative interactions, and adhesin variants with slightly shifted receptor epitopes. This epitopic variation may be a mechanism for shifting the host and tissue tropism of the bacteria, and may have evolved in response to the topography and expression of receptor epitopes at the host tissue surfaces.
authors.affiliation: Department of Cariology, Faculty of Odontology, University of Göteborg, Sweden.
authors.forename: N
authors.initials: N
authors.lastname: Strömberg
mesh_terms: D000190:Actinomyces / Q000502:physiology; D018830:Adhesins, Escherichia coli; D001422:Bacterial Adhesion / Q000502:physiology*; D001425:Bacterial Outer Membrane Proteins / Q000494:pharmacology; D001426:Bacterial Proteins / Q000494:pharmacology*; D004926:Escherichia coli / Q000502:physiology; D006017:Glycolipids / Q000494:pharmacology*; D007785:Lactose / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D018830:Adhesins, Escherichia coli; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D006017:Glycolipids; D008934:Mitogens; D011971:Receptors, Immunologic; C047105:bacterial adhesin receptor; D007785:Lactose