title: Methsuximide for intractable childhood seizures.
abstract: Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen. Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.
authors.affiliation: Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill 27599-7025.
authors.forename: M B
authors.initials: MB
authors.lastname: Tennison
authors.forename: R S
authors.initials: RS
authors.lastname: Greenwood
authors.forename: M V
authors.initials: MV
authors.lastname: Miles
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010672:Phenytoin / Q000097:blood / Q000627:therapeutic use; D013388:Succinimides / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D013388:Succinimides; C100286:methsuximide; C018504:N-desmethylmethsuximide; D002220:Carbamazepine; D010672:Phenytoin