title: Investigations of magnesium, histamine and immunoglobulins dynamics in acute urticaria.
abstract: In 42 urticaria patients, magnesium, histamine and IgE were dosed. Magnesium, IgE and histamine variations were followed in urticaria evolution, during acute phase and clinical remission. We noticed magnesium, histamine, IgE values variations depending on disease evolution and applied therapeutic scheme. Therefore: At disease starting point, histamine presented 3.5 times higher values than the normal ones. The value decreases following a curve which tends to reach normal values during clinical remission. At disease starting point, magnesium presented values under the inferior limit of the normal, 0.5 m mol/L respectively, as a mean. The value increases towards the normal limit during clinical remission. Immunoglobulins E follow a similar curve to histamine one, presenting 1,250 U/L values at the starting point, that, under medication, influence decrease between normal limits (800 U/L), during clinical remission. Analyzing the variations of biochemical parameters, the authors emphasize magnesium substitution treatment in urticaria.
authors.affiliation: Dermato-Venereal Research Center, Bucharest, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Mureşan
authors.forename: A
authors.initials: A
authors.lastname: Oană
authors.forename: I
authors.initials: I
authors.lastname: Nicolae
authors.forename: M
authors.initials: M
authors.lastname: Alecu
authors.forename: L
authors.initials: L
authors.lastname: Moşescu
authors.forename: V
authors.initials: V
authors.lastname: Benea
authors.forename: M
authors.initials: M
authors.lastname: Flueraş
mesh_terms: D000208:Acute Disease; D000328:Adult; D003348:Cortisone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006632:Histamine / Q000097:blood*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000276:immunology / Q000628:therapy; D007073:Immunoglobulin E / Q000032:analysis*; D008274:Magnesium / Q000097:blood*; D008297:Male; D014581:Urticaria / Q000097:blood* / Q000276:immunology / Q000628:therapy
chemical_list: D006634:Histamine H1 Antagonists; D007073:Immunoglobulin E; D006632:Histamine; D008274:Magnesium; D003348:Cortisone