MRI in tardive dyskinesia: shortened left caudate T2.
High-resolution magnetic resonance imaging of the brain was performed on 18 male schizophrenic patients, 14 with a cumulative exposure to neuroleptics of more than 1 year and 4 with less than 3 months of exposure. Calculated T2 relaxation time values were obtained for the basal ganglia. Patients with tardive dyskinesia (n = 9) had significantly shortened left caudate T2 relaxation times when compared to patients without tardive dyskinesia (n = 5). The group of four patients with fewer than 3 months' exposure to neuroleptics demonstrated a significantly greater variability of their left caudate T2 values. T2 relaxation time shortening may be related to iron levels in the basal ganglia and may be of predictive value in evaluating risk of tardive dyskinesia.
Bartzokis
G
G
Research Service, VA Medical Center West Los Angeles (Brentwood Division), CA 90073.
Garber
H J
HJ
Marder
S R
SR
Olendorf
W H
WH
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002421:Caudate Nucleus / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis* / Q000503:physiopathology; D005917:Globus Pallidus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010865:Pilot Projects; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D007501:Iron