Tubulosine: an antitumor constituent of Pogonopus speciosus.
From the antitumor-bioactive sap of Pogonopus speciosus, tubulosine [1] was isolated, by activity-directed fractionation using the brine shrimp lethality test, as the major antitumor constituent. 1H-nmr assignments, obtained from HETCOR and COSY, and X-ray crystallographic results are reported for the first time. Psychotrine [2] was also isolated, and its spectral data are also reported.
Ma
W W
WW
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Anderson
J E
JE
McKenzie
A T
AT
Byrn
S R
SR
McLaughlin
J L
JL
Hudson
M S
MS
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004640:Emetine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D007486:Ipecac / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; C009805:tubulosine; D007486:Ipecac; D004640:Emetine