title: Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury.
abstract: The effects of intravenous ibuprofen on measurements of pulmonary function and alveolar capillary membrane permeability to protein in sepsis-induced porcine acute lung injury (ALI) were studied. Young swine (15-25 kg) were anesthetized, cannulated, and ventilated (5 cm H2O PEEP, 0.5 FIO2, and 15 cc/kg tidal volume). Three groups were studied: septic animals (Ps, n = 10) received Pseudomonas aeruginosa for 1 hr IV, controls (C, n = 9) received 0.9% NaCl, and ibuprofen-treated septic animals (Ps + Ibu, n = 7) received ibuprofen 12.5 mg/kg at 0 and 120 min post Ps. Systemic (SAP) and pulmonary (PAP) arterial pressures, PaO2, cardiac index (CI), static lung compliance (CL), EVLW (thermal cardiogreen), and peripheral white blood cell counts (WBC) were measured. Bronchoalveolar lavage (BAL) was performed for protein and % neutrophil (%PMN) content.
  
  
  RESULTS
  Ps produced significant (p less than 0.05) decreases in CL, PaO2, SAP, CI, and peripheral WBC and increases in PAP, EVLW, BAL protein, and %PMN's vs. controls. Ibu prevented the early increase in PAP and attenuated the late increase in PAP and EVLW. Ibu also maintained PaO2, CL, BAL protein, and %PMN's in BAL at control levels, but exhibited no significant effect on peripheral leukopenia. These data strongly suggest that ibuprofen administered before and at 120 min after onset of Pseudomonas infusion improves lung compliance and affects neutrophil function sufficiently to significantly ameliorate many of the physiologic derangements in acute sepsis.
authors.affiliation: Department of Surgery, Medical College of Virginia, Virginia Commonwealt University, Richmond 23298-0519.
authors.forename: K
authors.initials: K
authors.lastname: Byrne
authors.forename: P D
authors.initials: PD
authors.lastname: Carey
authors.forename: T D
authors.initials: TD
authors.lastname: Sielaff
authors.forename: J K
authors.initials: JK
authors.lastname: Jenkins
authors.forename: C R
authors.initials: CR
authors.lastname: Blocher
authors.forename: K R
authors.initials: KR
authors.lastname: Cooper
authors.forename: A A
authors.initials: AA
authors.lastname: Fowler
authors.forename: H J
authors.initials: HJ
authors.lastname: Sugerman
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002199:Capillary Permeability; D015633:Extravascular Lung Water / Q000187:drug effects / Q000378:metabolism; D006439:Hemodynamics; D007052:Ibuprofen / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects*; D009504:Neutrophils / Q000473:pathology; D011506:Proteins / Q000378:metabolism*; D011552:Pseudomonas Infections / Q000150:complications*; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011651:Pulmonary Artery / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011506:Proteins; D007052:Ibuprofen