Role of RpoH, a heat shock regulator protein, in Escherichia coli carbon starvation protein synthesis and survival.
Escherichia coli starvation proteins include several heat shock proteins whose induction by heat is controlled by the minor sigma factor, sigma 32. The level of sigma 32 increased in wild-type E. coli upon starvation, and three sigma 32-controlled heat shock proteins (DnaK, GroEL, and HtpG) were not induced during starvation in an isogenic delta rpoH strain, which is unable to synthesize sigma 32. Thus, sigma 32 plays a role in the induction of these proteins during both heat shock and starvation. The delta rpoH strain was more sensitive to starvation but could develop starvation-mediated cross protection against heat and oxidation.
Jenkins
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Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402.
Auger
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EA
Matin
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A
D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics; D002244:Carbon / Q000378:metabolism; D002872:Chromosome Deletion; D015180:Electrophoresis, Gel, Two-Dimensional; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006358:Hot Temperature; D012808:Sigma Factor / Q000502:physiology*; D013217:Starvation
D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D012808:Sigma Factor; D002244:Carbon; D005947:Glucose