Accumulation of hyporesponsive, calcium extruding memory T cells as a key feature of age-dependent immune dysfunction.
In this review I propose a hypothesis with a number of testable predictions: that the age-dependent decline in T lymphocyte function is largely the result of the accumulation of memory T lymphocytes with over-active plasma membrane calcium pumps. This idea is consistent with much, though not all, of the currently available data. I will start by presenting the evidence that suggested and most clearly supports this idea, then discuss apparently contrary data (some of it still difficult to reconcile with the model), and lastly consider the implications of the model for our understanding of late life development of the T cell immune system.
Miller
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RA
Department of Pathology, Boston University School of Medicine, Massachusetts 02118.
D000375:Aging / Q000276:immunology*; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007156:Immunologic Memory; D015759:Ionomycin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000502:physiology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D015759:Ionomycin; D002118:Calcium