title: [Causes and medical effects of cocaine abuse].
abstract: Historical data concerning the use of cocaine, its epidemiology, chemistry and pharmacology, as well as its medical complications and treatment, in both acute intoxication and chronic addiction is reported. Its repercussion and damage upon the nervous system with neurologic and psychiatric alterations is also reported. The frequency of cerebral hemorrhages and myocardial, and other visceral, infarctions due to vascular lesions are discussed. Various pulmonary lesions produced by the different routes used and the multiple obstetric problems during pregnancy, such as abnormal labour with products showing cerebral damage and teratogenic lesions due to the use of cocaine are presented. Lastly, the present prophylactic campaigns against the use of cocaine and other drugs is mentioned.
authors.affiliation: Laboratorio de Neuromorfología Celular, Instituto Nacional de Neurología y Neurocirugía, Dr. Manuel Velasco Suárez.
authors.forename: R
authors.initials: R
authors.lastname: Barroso-Moguel
authors.forename: J
authors.initials: J
authors.lastname: Villeda-Hernández
authors.forename: M
authors.initials: M
authors.lastname: Méndez-Armenta
mesh_terms: D000293:Adolescent; D000328:Adult; D000777:Anesthetics / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D003042:Cocaine / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009422:Nervous System Diseases / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D014481:United States / Q000453:epidemiology
chemical_list: D000777:Anesthetics; D000697:Central Nervous System Stimulants; D003042:Cocaine