Cytotoxic alpha/beta+ and gamma/delta+ T cells in murine intestinal epithelium.
Murine intraepithelial lymphocytes (IEL) consist of two main populations. Approximately half are Thy-1+, most of which are CD3+, T cell receptor (TcR) alpha/beta+, and the remainder are Thy-1-, most of which are CD3+, TcR alpha/beta- (presumably TcR gamma/delta+). In redirected cytotoxicity assays, TcR alpha/beta+ IEL are potent cytotoxic effectors. Thy-1-, CD3+, TcR alpha/beta- IEL isolated from athymic mice are also cytotoxic. Thus, regardless of TcR usage or Thy-1 expression, IEL are cytotoxic effectors.
Viney
J L
JL
Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, GB.
Kilshaw
P J
PJ
MacDonald
T T
TT
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D017252:CD3 Complex; D005434:Flow Cytometry; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000502:physiology
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D018800:Thy-1 Antigens