title: Sir Horace Smirk. Pioneer in drug treatment of hypertension.
abstract: Sir Horace Smirk deserves much of the credit for establishing the benefits of reducing blood pressure. He was one of the main early proponents of the idea that it was the raised intra-arterial pressure itself that caused many of the cardiac and vascular complications of hypertension. His training in both pharmacology and internal medicine enabled him to devise practical methods for successful treatment of hypertension with ganglion blocking drugs such as hexamethonium. The major clinical benefits that followed such drug treatment proved a great stimulus to the development of drugs with fewer disadvantages and to widespread acceptance of the beneficial effects of antihypertensive drug treatment.
authors.affiliation: University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia.
authors.forename: A E
authors.initials: AE
authors.lastname: Doyle
mesh_terms: D000959:Antihypertensive Agents / Q000266:history*; D004739:England; D049673:History, 20th Century
chemical_list: D000959:Antihypertensive Agents