Kynurenic acid blocks chemogenic nociception.
Previous studies have suggested a role of excitatory amino acids (EAA) in nociception. In the present study the effects of two antagonists of EAA-receptors on capsaicin-induced eye wipings were investigated. Intracisternally administered kynurenic acid, in contrast to intravenously administered MK-801, was found to effectively block the induced eye wipings. It is proposed that EAA, by activating non-NMDA receptors, are involved in the transmission of chemogenic nociception.
Hajós
M
M
Department of Physiology, A. Szent-Györgyi Medical University, Szeged, Hungary.
Engberg
G
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D002946:Cisterna Magna; D016291:Dizocilpine Maleate / Q000494:pharmacology; D007267:Injections; D007736:Kynurenic Acid / Q000494:pharmacology*; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D007736:Kynurenic Acid; D002211:Capsaicin