The effect of clobetasol-17-propionate and crude coal tar on dithranol-induced inflammation. A clinical and biochemical study.
Clobetasol-17-propionate (CP) and crude coal tar (CT) have an anti-inflammatory potential. Both agents have been advocated to suppress irritation of the skin during dithranol treatment. The effect of CP and CT on dithranol-induced irritation was studied by the assessment of erythema and measurement of alkaline phosphatase (ALP) as a direct reflection of the metabolic activity of the endothelial cells. Dithranol was applied for 2 h in the relatively high concentration of 10%, which resulted in a marked inflammation of the skin in all volunteers. Neither CP nor CT influenced the erythema. In contrast, CP and CT had a synergistic effect on the dithranol-induced induction of ALP. In conclusion, the present study indicates that CP and CT are not indicated for the treatment of dithranol-induced irritation.
van de Kerkhof
P C
PC
Department of Dermatology, University of Nijmegen, The Netherlands.
Timmerman
M G
MG
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D000875:Anthralin / Q000009:adverse effects*; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003033:Coal Tar / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000188:drug therapy
D003033:Coal Tar; D002990:Clobetasol; D000469:Alkaline Phosphatase; D000875:Anthralin