[Modifying effects of neurotropin on post-radiation disorders of neuromediator processes in the autonomic function regulation centers].
In experiments on Wistar rats, it was shown that 6 months after exposure to ionizing radiation (X-radiation 0.5 Gy and intraperitoneal 131I 6.5 mCu/kg) the hypothyroid state was accompanied by changes in inhibitory and excitatory mediation that are characteristic of chronic radiation stress in cerebral structures responsible for regulation of autonomic and animal functions and a relative deficiency of the hypothalamopituitary-adrenocortical axis. Application of therapeutic doses of neurotropin 3 months after radiation levelled the pattern of chronic radiation stress and diencephalic disorders that underlie disturbances of some systemic functions of the organism.
Gurin
V N
VN
Taĭts
M Iu
MIu
Dubina
T V
TV
Elkina
A I
AI
Kandybo
T S
TS
Tsykhun
G F
GF
Konishi
Zh E
ZhE
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001341:Autonomic Nervous System / Q000528:radiation effects*; D001921:Brain / Q000528:radiation effects*; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000276:Adjuvants, Immunologic; D018377:Neurotransmitter Agents; D011134:Polysaccharides; C010491:neurotropin