Mitogenic activity of natural and synthetic lignins against cultured splenocytes.
Various natural lignified materials and synthetic dehydrogenation polymers (the so-called synthetic lignins) prepared from several phenylpropenoids were investigated for their mitogenic activity. All of these materials time- and dose-dependently stimulated the DNA synthesis of isolated mouse splenocytes. However, their stimulating activity was significantly decreased when the splenocytes were pretreated with anti-Thy-1.2 monoclonal antibody and rabbit complement. Natural and synthetic lignins demand attention as potential immunopotentiators.
Kurakata
Y
Y
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Sakagami
H
H
Oh-Hara
T
T
Kawazoe
Y
Y
Asano
K
K
Fujinaga
S
S
Takeda
M
M
Sato
T
T
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008031:Lignin / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D008934:Mitogens; D010936:Plant Extracts / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D018800:Thy-1 Antigens
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D008934:Mitogens; D010936:Plant Extracts; D018800:Thy-1 Antigens; D008031:Lignin