Preliminary results on cystic fibrosis haplotypes from patients diagnosed in Odessa.
Two RFLP's closely linked to the CF gene (KM.19/PstI and XV-2c/TaqI) have been analysed in a sample of CF families in which one or more affected children had been diagnosed by the CF Centre of Odessa. The most frequent haplotype in CF chromosomes (2-1) is the same observed with higher frequency in other populations. If confirmed on a larger sample of CF patients from the USSR, this result might be indicative of heterogeneity of mutations present in the Soviet population.
De Benedetti
L
L
Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
Ronchetto
P
P
Devoto
M
M
Romeo
G
G
Krainiaia
G V
GV
Reznik
B Y
BY
D000483:Alleles; D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length