title: A case report of cimetidine-induced clozapine toxicity.
abstract: Cimetidine may decrease concomitant medication clearance by inhibiting the oxidative system of cytochrome P-450. The authors report increased serum clozapine levels and adverse side effects during clozapine and cimetidine treatment but not during clozapine and ranitidine treatment in a patient with chronic paranoid schizophrenia.
authors.affiliation: Psychiatric Research Department, Hillside Hospital, Glen Oaks, NY 11004.
authors.forename: S
authors.initials: S
authors.lastname: Szymanski
authors.forename: J A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: D
authors.initials: D
authors.lastname: Picou
authors.forename: S
authors.initials: S
authors.lastname: Masiar
authors.forename: T
authors.initials: T
authors.lastname: Cooper
mesh_terms: D000328:Adult; D002908:Chronic Disease; D002927:Cimetidine / Q000009:adverse effects* / Q000494:pharmacology; D003024:Clozapine / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000493:pharmacokinetics / Q000627:therapeutic use; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000523:psychology
chemical_list: D002927:Cimetidine; D011899:Ranitidine; D003024:Clozapine