Comparative effects of (+)-propranolol and nonoxynol-9 on human sperm motility in-vitro.
Using the modified transmembrane migration method to measure sperm motility, it was shown that the surfactant nonoxynol-9 alone, was twice as potent as (+)-propranolol alone as a spermicidal agent. Addition of (+)-propranolol to nonoxynol-9 shifted the dose-response curve to the left of the curves for either component alone, and a surprising synergistic action was evident. These observations may form the basis for the development of a new advantageous topical contraceptive combination product.
Gadd
A L
AL
Cambridge Research Institute, Histon, UK.
Curtis-Prior
P B
PB
D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013089:Spermatocidal Agents / Q000008:administration & dosage / Q000494:pharmacology*
D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols; D011433:Propranolol