title: Sensitivity of technetium-99m-d,1-HMPAO to radiolysis in aqueous solutions.
abstract: The sensitivity of technetium-99m- (99mTc) d,l-HMPAO to radiolytically induced dissociation in aqueous solutions was investigated. It was found that cobalt-60 (60Co) gamma irradiation of solutions containing 99mTc-d,l-HMPAO with only 1600 cGy reduced the lipophilic chelates' radiochemical purity (RCP) to 50%-60%. The radiolytic sensitivity of 99mTc-meso-HMPAO is significantly lower. The results indicate that radiolytically produced intermediates limit the in vitro stability of 99mTc-d,l-HMPAO.
authors.affiliation: Research Service, Harry S. Truman Veterans Administration Hospital, Columbia, Missouri.
authors.forename: K
authors.initials: K
authors.lastname: Tubergen
authors.forename: M
authors.initials: M
authors.lastname: Corlija
authors.forename: W A
authors.initials: WA
authors.lastname: Volkert
authors.forename: R A
authors.initials: RA
authors.lastname: Holmes
mesh_terms: D003037:Cobalt Radioisotopes; D004355:Drug Stability; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000528:radiation effects*; D010091:Oximes / Q000737:chemistry / Q000528:radiation effects*; D011829:Radiation Dosage; D011854:Radiochemistry; D019690:Technetium Tc 99m Exametazime; D014867:Water
chemical_list: D003037:Cobalt Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D014867:Water; D019690:Technetium Tc 99m Exametazime