Peptide analysis of the T cell response to the malaria circumsporozoite (CS) protein.
The T cell response to the circumsporozoite (CS) protein is still not well understood. There is still not agreement on the degree of immunological non-responsiveness or even on the basic question of whether the response to native CS protein requires T cells at all. Recombinant proteins and synthetic peptides are tools that are helping us learn the basics of the immune response to this protein. Here, the human and murine responses to the protein are probed using these valuable research tools. Then, the possibility of using peptide vaccines is discussed.
Good
M F
MF
Tropical Health Program, Queensland Institute of Medical Research, Herston, Brisbane, Australia.
Zevering
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000953:Antigens, Protozoan; D010446:Peptide Fragments; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan