Superwarfarin ingestion and detection.
Because of the emergence of warfarin resistance, new potent long-acting anticoagulants are now readily available in several over-the-counter rodenticide products. The availability of these "superwarfarin" compounds has led to accidental and purposeful human ingestions, one of which has resulted in a death. We summarize the prior case reports and report a second death. In addition, we report the availability of an assay to detect the presence of brodifacoum (a superwarfarin compound) in human plasma and tissues.
Routh
C R
CR
Medical Education Department, Ball Memorial Hospital, Muncie, Indiana 47303.
Triplett
D A
DA
Murphy
M J
MJ
Felice
L J
LJ
Sadowski
J A
JA
Bovill
E G
EG
D015110:4-Hydroxycoumarins / Q000097:blood / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009994:Osmolar Concentration; D012378:Rodenticides / Q000506:poisoning; D019966:Substance-Related Disorders / Q000175:diagnosis*; D014812:Vitamin K / Q000097:blood; D014859:Warfarin
D015110:4-Hydroxycoumarins; D012378:Rodenticides; D014812:Vitamin K; D014859:Warfarin; C013418:bromfenacoum