Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo.
Sterculic acid, a delta-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P less than 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effect of sterculic acid on tumour growth. Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour. Tumour growth was inhibited equally by the two doses of sterculic acid (P less than 0.001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats.
Khoo
D E
DE
Academic Department of Surgery, Royal Free Hospital, London, UK.
Fermor
B
B
Miller
J
J
Wood
C B
CB
Apostolov
K
K
Barker
W
W
Williamson
R C
RC
Habib
N A
NA
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003521:Cyclopropanes / Q000627:therapeutic use* / Q000633:toxicity; D004361:Drug Tolerance; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000517:prevention & control*; D051379:Mice; D009829:Oleic Acids / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D013229:Stearic Acids / Q000378:metabolism
D003521:Cyclopropanes; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D009829:Oleic Acids; D013229:Stearic Acids; C003345:sterculic acid