The combined action of exercise and methylprednisolone sodium succinate on the rat gastrocnemius muscle.
1. Methylprednisolone sodium succinate (SM) administration reduces the amount of contractile proteins and increases the collagen in the rat gastrocnemius muscle; it also increases the muscle's isotonic contraction capacity. 2. Exercise in combination with SM treatment reduces this capacity and causes also further reductions of the contractile proteins and increases of collagen. 3. There are no changes of either the relative muscle weight or the number of acetylcholine receptors in any experimental group as compared to controls.
Stergiou-Michailidou
V
V
Department of Physiology, Faculty of Medicine, Aristotelion University of Thessaloniki, Greece.
Kontoleon-Vakalopoulou
E
E
D000818:Animals; D003094:Collagen / Q000378:metabolism; D003285:Contractile Proteins / Q000378:metabolism; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003285:Contractile Proteins; D008776:Methylprednisolone Hemisuccinate; D003094:Collagen