Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene.
Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.
Abbs
S
S
Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.
Roberts
R G
RG
Mathew
C G
CG
Bentley
D R
DR
Bobrow
M
M
D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D007438:Introns; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic