title: Diaphragmatic fatigue produced by constant or modulated electric currents.
abstract: In anesthetized rabbits the efficiency of phrenic nerve stimulation with trains of electric current was studied either when ventilation was effected entirely by bilateral nerve stimulation (electrophrenic ventilation) or during unilateral nerve stimulation when animals were ventilated with a pump and open chest. Trains of rectangular electric pulses (RPT) with constant amplitude and frequency or sine waves, both the amplitude and frequency of which were modulated and controlled by a computer (MSWT), were used with each animal. MSWT closely reproduced the physiological shape of transdiaphragmatic pressure waves. Diaphragm fatigue, as determined from the decrease in the maximal relaxation rate of twitches, occurred after 20 minutes of bilateral or unilateral nerve stimulation with RPT, but only after 60 min (unilateral stimulation) or 98 min (bilateral stimulation) with MSWT. These data show the importance of the motor signal pattern in long-lasting nerve stimulation.
authors.affiliation: Laboratoire de Biologie des Hautes Pressions, Faculté de Médecine, Marseille, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Jammes
authors.forename: P
authors.initials: P
authors.lastname: Collett
authors.forename: P
authors.initials: P
authors.lastname: Lenoir
authors.forename: A
authors.initials: A
authors.lastname: Lama
authors.forename: F
authors.initials: F
authors.lastname: Berthelin
authors.forename: C
authors.initials: C
authors.lastname: Roussos
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000294:innervation* / Q000502:physiology; D004599:Electric Stimulation Therapy; D009119:Muscle Contraction; D010791:Phrenic Nerve / Q000502:physiology*; D011817:Rabbits; D012121:Respiration, Artificial; D012133:Respiratory Paralysis / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors