[Effects of H2-receptor antagonist on gastrin and somatostatin secretion of rat stomach].
To investigate the effects of 14 days administration of H2-receptor antagonist (famotidine) on gastric gastrin and somatostatin secretion, bombesin and glucagon were perfused in the isolated pancreas-duodenum deprived rat stomach. Then serum gastrin concentration, gastric mucosal gastrin and somatostatin content, and gastric mucosal G-cell and D-cell numbers were examined. The 14 days administration of famotidine caused the significant increase of basal gastrin secretion, antral G-cell hyperplasia, high gastrin sensitivity to the stimulation by bombesin, and the low somatostatin sensitivity to the stimulation by glucagon. These facts would suggest that 14 days famotidine administration disturbed not only gastrin secretion but also somatostatin secretion. These results may contribute, at least in part, to the high recurrence of ulcers after withdrawal of H2-receptor antagonists.
Yoshikawa
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N
Second Department of Internal Medicine, Chiba University School of Medicine.
D000818:Animals; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D005755:Gastrins; D006635:Histamine H2 Antagonists; D013004:Somatostatin