Apolipoprotein E polymorphism influences the serum cholesterol response to dietary intervention.
The association between apolipoprotein (apo) E polymorphism and the response of serum cholesterol to dietary counseling and to gemfibrozil treatment was investigated in 230 dyslipidemic middle-aged participants of the Helsinki Heart Study. Baseline lipid levels were not significantly different between subjects with or without the epsilon 4 allele. Following dietary counseling, participants with the epsilon 4 allele exhibited a greater reduction in serum total cholesterol (P less than .01) and low-density lipoprotein (LDL)-cholesterol (P less than .02) than those without the epsilon 4 allele, while the changes in high-density lipoprotein (HDL)-cholesterol and triglycerides were similar in the two groups. The alterations observed in total cholesterol, HDL-cholesterol, and triglycerides during treatment with gemfibrozil were not different between subjects with or without the epsilon 4 allele. The presence of the epsilon 4 allele and baseline serum cholesterol independently predicted the degree of cholesterol reduction following dietary counseling.
Mänttäri
M
M
First Department of Medicine, Helsinki University Central Hospital, Finland.
Koskinen
P
P
Ehnholm
C
C
Huttunen
J K
JK
Manninen
V
V
D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D015248:Gemfibrozil / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010641:Phenotype; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol; D015248:Gemfibrozil