Familial alcoholism in primary unipolar major depressive disorder.
OBJECTIVE
Some studies have suggested relationships between depression in probands and alcoholism in relatives. Other studies have not, but some of these have used inappropriate control groups or failed to divide probands by sex.


METHODS
The present study controlled for sex of probands and used several comparison groups to further explore the familial relationship between depression and alcoholism. Diagnoses for 723 directly interviewed relatives of 326 probands with primary unipolar depression were compared to diagnoses in 469 control subjects chosen by an acquaintanceship method to demographically resemble the relatives of affective disorder probands. Diagnoses in the uninterviewed relatives of both control and depressed subjects were used for comparisons as well.


RESULTS
Results indicated higher rates of alcoholism in the families of depressed women but not in the families of depressed men.


CONCLUSIONS
This familial association between alcoholism and depression may be the result of either genetic or environmental factors or an interaction between the two.
Winokur
G
G
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Coryell
W
W
D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D000553:Ambulatory Care; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005190:Family; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012737:Sex Factors