title: Dose-dependent inhibitory effect of phenolic compounds in foods on nonheme-iron absorption in men.
abstract: Nonheme-iron absorption from a typical Southeast Asian meal was studied to examine the effect of a common vegetable, Yod Kratin, which contains a considerable amount of iron-binding phenolic groups. Yod Kratin (leaves of the lead tree) is a very popular vegetable in Thailand. It is consumed at least once a week year round, sometimes every day, together with the main meal. With a common portion size of the vegetable (20 g), iron absorption was reduced by almost 90%. As little as 5 g inhibited iron absorption by 75%. Addition of ascorbic acid partly counteracted inhibition. Adding 100 mg ascorbic acid reduced inhibition of iron absorption from 5 g Yod Kratin by half and the inhibition from 10 g Yod Kratin by a quarter. The study illustrates the marked effect of iron-binding phenolic compounds on iron nutrition and, thus, the importance of acquiring knowledge of the content of such compounds in different foods.
authors.affiliation: Department of Radiology, Siriraj Hospital, Mahidol University, Göteborg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Tuntawiroon
authors.forename: N
authors.initials: N
authors.lastname: Sritongkul
authors.forename: M
authors.initials: M
authors.lastname: Brune
authors.forename: L
authors.initials: L
authors.lastname: Rossander-Hultén
authors.forename: R
authors.initials: R
authors.lastname: Pleehachinda
authors.forename: R
authors.initials: R
authors.lastname: Suwanik
authors.forename: L
authors.initials: L
authors.lastname: Hallberg
mesh_terms: D000042:Absorption; D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005502:Food; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics*; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D013634:Tannins / Q000494:pharmacology; D013785:Thailand; D014675:Vegetables
chemical_list: D010636:Phenols; D013634:Tannins; D007501:Iron; D001205:Ascorbic Acid