title: The design of a novel class of potassium channel activating drugs, 2-(2,2-dimethylbenzopyran-4-yl)-pyridine-1-oxides.
abstract: The features of cromakalim responsible for its potassium channel activating property were investigated. A hypothesis relating three-dimensional structure to binding to a putative receptor was developed and used successfully to design the potent and structurally novel agents, 2-(2,2-dimethylbenzopyran-4-yl)-pyridine-1-oxides.
authors.affiliation: Roche Products Limited, Welwyn Garden City, Herts, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Attwood
authors.forename: P S
authors.initials: PS
authors.lastname: Jones
authors.forename: P B
authors.initials: PB
authors.lastname: Kay
authors.forename: P M
authors.initials: PM
authors.lastname: Paciorek
authors.forename: S
authors.initials: S
authors.lastname: Redshaw
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D019806:Cromakalim; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D015195:Drug Design; D066298:In Vitro Techniques; D008297:Male; D015221:Potassium Channels / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D001578:Benzopyrans; D001993:Bronchodilator Agents; D003497:Cyclic N-Oxides; D015221:Potassium Channels; D011725:Pyridines; D011758:Pyrroles; D014665:Vasodilator Agents; D019806:Cromakalim