title: Adenyl cyclase activity in human alveolar macrophages.
abstract: The inflammatory mediators PGE2, DC-PGI2 and histamine as well as the beta-adrenergic drugs isoprenaline and salbutamol increase intracellular cyclic AMP-concentrations whereas Platelet Activating Factor does not induce any change in adenyl cyclase activity of normal human alveolar macrophages. Functional H2-histaminergic and beta 2-adrenergic receptor-subtypes are coupled to macrophage adenyl cyclase.
authors.affiliation: Department of Pharmacology, Erasmus University Rotterdam, The Netherlands.
authors.forename: F D
authors.initials: FD
authors.lastname: Beusenberg
authors.forename: J G
authors.initials: JG
authors.lastname: van Amsterdam
authors.forename: J M
authors.initials: JM
authors.lastname: van Schaik
authors.forename: H C
authors.initials: HC
authors.lastname: Hoogsteden
authors.forename: I L
authors.initials: IL
authors.lastname: Bonta
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism
chemical_list: D000318:Adrenergic beta-Agonists; D011453:Prostaglandins; D006632:Histamine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases