title: Design and synthesis of an opioid receptor probe: mode of binding of S-activated (-)-6 beta-sulfhydryldihydromorphine with the SH group in the mu-opioid receptor.
authors.affiliation: Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kanematsu
authors.forename: R
authors.initials: R
authors.lastname: Naito
authors.forename: Y
authors.initials: Y
authors.lastname: Shimohigashi
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Ogasawara
authors.forename: M
authors.initials: M
authors.lastname: Kurono
authors.forename: K
authors.initials: K
authors.lastname: Yagi
mesh_terms: D000701:Analgesics, Opioid; D000818:Animals; D004090:Dihydromorphine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D015195:Drug Design; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009022:Morphine Derivatives / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011957:Receptors, Opioid / Q000378:metabolism*; D017450:Receptors, Opioid, mu; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D009022:Morphine Derivatives; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D013438:Sulfhydryl Compounds; C065473:6-(5'-nitro-2'-pyridyldithio)deoxydihydromorphine; D004090:Dihydromorphine