Acid-base equilibria of beta-blockers in acetonitrile.
The acid-base equilibria of a series of beta-adrenoceptor blocking drugs in acetonitrile have been studied, and pKHB+ values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of beta-adrenoceptor blocking drugs.
Barbosa
J
J
Department of Analytical Chemistry, University of Barcelona, Spain.
Sanz-Nebot
V
V
Torrero
M E
ME
D000097:Acetonitriles / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D007202:Indicators and Reagents; D007700:Kinetics; D011199:Potentiometry
D000097:Acetonitriles; D000319:Adrenergic beta-Antagonists; D007202:Indicators and Reagents