title: [Prevention of adhesions in abdominal surgery. A dose finding study with streptokinase/streptodornase].
abstract: Measurement of intraperitoneal fibrinolytic activity on 50 patients having undergone abdominal surgery (four of them controls). Instillation of streptokinase/streptodornase (Varidase) into the abdominal cavity. Determination of total protein, plasminogen, antiplasmin, alpha 2 Mx-plasmin-complex, spontaneous fibrinolysis and fibrinolysis + activator at different points in time p.op.
  
  
  RESULTS
  Intraperitoneal fibrinolysis may be stimulated by local substitution of a plasminogen activator (Varidase). Systemic effects are confined to a high dose. No impaired wound healing nor increased propensity to hemorrhaging occurred.
authors.affiliation: I. Chirurgische Abteilung KA Rudolfstiftung Wien.
authors.forename: A
authors.initials: A
authors.lastname: Tuchmann
authors.forename: K
authors.initials: K
authors.lastname: Dinstl
authors.forename: D
authors.initials: D
authors.lastname: Depisch
authors.forename: P
authors.initials: P
authors.lastname: Wendt
authors.forename: G
authors.initials: G
authors.lastname: Blümel
mesh_terms: D000005:Abdomen / Q000601:surgery*; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D010533:Peritoneal Lavage; D011183:Postoperative Complications / Q000517:prevention & control*; D013299:Streptodornase and Streptokinase / Q000008:administration & dosage* / Q000009:adverse effects; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D013299:Streptodornase and Streptokinase