Hypocholesterolaemic factor from gallbladder cancer cells.
A patient is reported with drug-resistant familial hypercholesterolaemia in whom serum cholesterol fell after the onset of gallbladder cancer with intraperitoneal invasion. Cancer cells were obtained from ascitic fluid and a cultured cell line established. Incubation of the culture medium of these cells with skin fibroblasts from the patient and from normal subjects increased low-density lipoprotein (LDL) receptor activity in a dose-dependent manner. These results show that gallbladder cancer cells from this patient secrete a substance that stimulates LDL receptor activity. This substance may have contributed towards reduction of serum cholesterol.
Ueyama
Y
Y
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Matsuzawa
Y
Y
Yamashita
S
S
Funahashi
T
T
Sakai
N
N
Nakamura
T
T
Kubo
M
M
Tarui
S
S
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D001202:Ascitic Fluid / Q000166:cytology; D002784:Cholesterol / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005706:Gallbladder Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D011973:Receptors, LDL / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D014407:Tumor Cells, Cultured
D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D002784:Cholesterol