Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine.
Histamine-induced wheals and flares were measured in seven healthy volunteers zero, four, and eight hours after oral intake of cetirizine, 2.5, 5, and 10 mg; loratadine, 10, 20, and 40 mg; and placebo. Cetirizine (2.5, 5, and 10 mg) and loratadine (20 and 40 mg) significantly inhibited the histamine-induced wheals at all experimental times and with all histamine concentrations. This was not always the case with loratadine, 10 mg. Cetirizine, 2.5 mg, was as potent in inhibiting the histamine skin reactivity as loratadine, 10 mg.
Rihoux
J P
JP
UCB, SA, Pharmaceutical Sector, Chemin du Foriest, Belgium.
Ghys
L
L
Coulie
P
P
D000328:Adult; D017332:Cetirizine; D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006632:Histamine / Q000009:adverse effects; D006633:Histamine Antagonists / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D006993:Hypnotics and Sedatives; D017336:Loratadine; D008297:Male; D008875:Middle Aged; D010919:Placebos; D016032:Randomized Controlled Trials as Topic
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D010919:Placebos; D003533:Cyproheptadine; D006919:Hydroxyzine; D017336:Loratadine; D006632:Histamine; D017332:Cetirizine