The effect of anti-neoplastic drugs on murine acquired immunodeficiency syndrome.
The murine acquired immunodeficiency syndrome (MAIDS) is associated with proliferation of target cells that have been infected by a defective retrovirus. To control the growth of this primary neoplasia, virus-inoculated mice were treated with anti-neoplastic drugs. Paradoxically, cyclophosphamide, which is also immunosuppressive, was very effective in preventing the appearance and progression of the disease, in restoring a normal T cell function, and in depleting the number of infected target cells. This result suggests that the proliferating infected target cells were responsible for the immunodeficiency.
Simard
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C
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada.
Jolicoeur
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P
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015152:Blotting, Northern; D015139:Blotting, Southern; D002455:Cell Division; D003520:Cyclophosphamide / Q000627:therapeutic use; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D016183:Murine Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D013154:Spleen / Q000473:pathology; D014779:Virus Replication
D000970:Antineoplastic Agents; D012367:RNA, Viral; D003520:Cyclophosphamide