Preprandial blood glucose values and glycemic responses in insulin-dependent diabetes mellitus at constant insulinemia.
The influence of preprandial blood glucose (PPBG) concentration on glycemic responses was studied in seven subjects with insulin-dependent diabetes who, by means of the artificial pancreas, had achieved PPBG concentrations of 6, 9, and 17 mmol/L. A test meal of 50 g parboiled rice was given at the three different occasions and a constant insulin infusion was provided during the observation periods. The mean postprandial-blood-glucose-response area (above basal) differed significantly at the three blood glucose concentrations of 6, 9, and 17 mmol/L, reaching 1371, 621, and 179 mmol/L x 240 min, respectively (P less than 0.01). A negative correlation between the PPBG concentrations and the glycemic responses to the test meal was found (r = 0.94; P less than 0.001). The fasting insulin concentration at a PPBG concentration of 17 mmol/L was lower than at a PPBG concentration of 6 and 9 mmol/L. In conclusion, the glycemic responses to a carbohydrate meal are inversely correlated to the PPBG concentration in insulin-dependent diabetic subjects.
Rasmussen
O
O
Second University Clinic of Internal Medicine, Arhus Kommunehospital, Denmark.
Hermansen
K
K
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000628:therapy; D004435:Eating; D005215:Fasting; D006801:Humans; D007328:Insulin / Q000097:blood*; D007332:Insulin Infusion Systems; D008297:Male; D012275:Oryza; D009994:Osmolar Concentration
D001786:Blood Glucose; D007328:Insulin