title: Beneficial response to megoestrol acetate in AIDS-related cachexia and a possible megoestrol withdrawal-associated syndrome?
abstract: A man with AIDS is described in whom a profound weight loss was converted into a weight gain by treatment with megoestrol acetate, a synthetic progesterone. His appetite improved and was accompanied by a feeling of improved well-being. Following abrupt discontinuation of the drug, there was a significant but transient depression of mood and appetite associated with loss of energy; it is suggested that this complex of symptoms might represent a megoestrol acetate withdrawal-associated syndrome.
authors.affiliation: Department of Infection & Tropical Medicine, Ruchill Hospital, Glasgow, Scotland.
authors.forename: D
authors.initials: D
authors.lastname: Nathwani
authors.forename: S T
authors.initials: ST
authors.lastname: Green
authors.forename: J M
authors.initials: JM
authors.lastname: Heslop
authors.forename: D J
authors.initials: DJ
authors.lastname: Goldberg
authors.forename: D H
authors.initials: DH
authors.lastname: Kennedy
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology; D003863:Depression / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008535:Megestrol / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome; D015431:Weight Loss
chemical_list: D008535:Megestrol