title: Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease.
abstract: Serious respiratory depression may occur in patients with chronic obstructive pulmonary disease (COPD), receiving hypnotics during acute exacerbations. However, in a previous study on oxygenation during sleep in patients with stable hypoxemic non-hypercapnic COPD, we were unable to demonstrate a significant negative effect from single doses of nitrazepam and flunitrazepam. We have now investigated the effects of propiomazine, a phenothiazine hypnotic, in a double-blind randomized cross-over study of oxygen saturation and apneas during sleep and other sleep variables in 12 non-obese hypoxemic but clinically stable theophylline-treated COPD patients (PaO2 8.1 kPa, PaCO2 5.6 kPa, FEV1 31% of predicted value). None of the respiratory variables were adversely affected by a single oral dose of 25 mg propiomazine, whereas total sleeping time and the sleep efficiency index increased.
authors.affiliation: Department of Lung Medicine, University Hospital, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Midgren
authors.forename: L
authors.initials: L
authors.lastname: Hansson
authors.forename: S
authors.initials: S
authors.lastname: Ahlmann
authors.forename: D
authors.initials: D
authors.lastname: Elmqvist
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010640:Phenothiazines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*
chemical_list: D010640:Phenothiazines; D010100:Oxygen