title: Replication intermediates as substrates for DNA rearrangements.
abstract: A model for the formation of DNA rearrangements in somatic cells is presented. Two double-strand breaks at the junctions between unreplicated DNA and newly replicated DNA generate four double-stranded DNA molecules that can recombine to form tandem duplications, inversions, deletions and extrachromosomal DNA circles.
authors.affiliation: Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750.
authors.forename: R B
authors.initials: RB
authors.lastname: Painter
authors.forename: L N
authors.initials: LN
authors.lastname: Kapp
mesh_terms: D002872:Chromosome Deletion; D007446:Chromosome Inversion; D004261:DNA Replication; D004270:DNA, Circular; D005057:Eukaryotic Cells / Q000648:ultrastructure; D015321:Gene Rearrangement; D008957:Models, Genetic
chemical_list: D004270:DNA, Circular