The biology and clinical applications of granulocyte-macrophage colony-stimulating factor.
GM-CSF is a hematopoietic growth factor that regulates myeloid cell proliferation and maturation and enhances the function of terminally differentiated effector cells. Results of clinical trials with GM-CSF in a number of disease states suggest a potential role of this growth factor to stimulate hematopoiesis. Future use of GM-CSF will depend on further studies to optimize its therapeutic efficacy.
Sakamoto
K M
KM
Division of Hematology/Oncology, Children's Hospital, Los Angeles, CA 90027.
Golde
D W
DW
Gasson
J C
JC
D001695:Biology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans
D016178:Granulocyte-Macrophage Colony-Stimulating Factor