Lack of neuropathological changes in rats after exposure to butyl benzyl phthalate.
Butyl benzyl phthalate (BBP; Santicizer 160 Plasticizer) was fed to 3 groups of 10 male and 10 female Charles River CD rats for 6 wk at target doses of 500, 1500, and 3000 mg/kg/d. Control groups of 6 males and 6 females received untreated diets for the same period. Body weight gains were decreased at the 1500 and 3000 mg/kg/d levels. Hindlimb stiffness was noted at the 3000 mg/kg/d level and was more prevalent in males. Stiffness was apparently reversed after withdrawal from BBP exposure for 2 d. Microscopic examination of central and peripheral nervous system tissues did not reveal any compound-related pathological changes. Thus, there were no morphological changes in the nervous system that could be related to the apparently reversible hindlimb stiffness.
Robinson
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Department of Medical and Health Sciences, Monsanto Company, St. Louis, Missouri 63167.
D000284:Administration, Oral; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D005684:Gait / Q000187:drug effects; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats
D010795:Phthalic Acids; C027561:butylbenzyl phthalate