Adenosine A2 stimulation of tyrosine hydroxylase in rat striatal minces is reversed by dopamine D2 autoreceptor activation.
The adenosine agonist, 2-chloroadenosine, stimulated tyrosine hydroxylase activity in rat striatal minces; this effect was attenuated by activation of dopamine (DA) D2 autoreceptors with N-n-propylnorapomorphine and antagonized by theophylline. Forskolin and 8-bromo-cAMP also increased tyrosine hydroxylase activity and their effects were not altered by 2-chloroadenosine. D1, alpha, beta and 5-HT agonists did not affect tyrosine hydroxylase activity. Evidently, A2 receptors on DA nerve terminals stimulate striatal DA synthesis and this effect is negatively modulated by D2 autoreceptors, probably via changes in intracellular cAMP levels.
Booth
R G
RG
Department of Psychiatry, Harvard Medical School, Boston, MA.
Baldessarini
R J
RJ
D015762:2-Chloroadenosine / Q000494:pharmacology; D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D015259:Dopamine Agents; D011954:Receptors, Dopamine; D011983:Receptors, Purinergic; D015762:2-Chloroadenosine; D005576:Colforsin; D015124:8-Bromo Cyclic Adenosine Monophosphate; C009074:N-n-propylnorapomorphine; D013806:Theophylline; D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase; D000241:Adenosine; D001058:Apomorphine