The sorption of isosorbide-5-mononitrate to intravenous delivery systems.
The sorption of isosorbide-5-mononitrate, diluted in 0.9% NaCl or 10% glucose solutions, to intravenous delivery systems was investigated. Infusion bags, burettes, a syringe, infusion tubings and end-line filters were tested in static and in dynamic experiments. No clinically significant sorption was detected during those experiments. The use of PVC tubings of different hardness did not influence the results.
De Muynck
C
C
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
Colardyn
F
F
Remon
J P
JP
D000327:Adsorption; D005947:Glucose / Q000737:chemistry; D006244:Hardness; D007262:Infusions, Intravenous; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000737:chemistry; D010968:Plasticizers; D011143:Polyvinyl Chloride; D012408:Rubber; D012965:Sodium Chloride; D012996:Solutions; D013594:Syringes
D010968:Plasticizers; D012996:Solutions; D012965:Sodium Chloride; D011143:Polyvinyl Chloride; D012408:Rubber; D007548:Isosorbide Dinitrate; D005947:Glucose; C030397:isosorbide-5-mononitrate