title: Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene.
abstract: Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.
authors.affiliation: Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Abbs
authors.forename: R G
authors.initials: RG
authors.lastname: Roberts
authors.forename: C G
authors.initials: CG
authors.lastname: Mathew
authors.forename: D R
authors.initials: DR
authors.lastname: Bentley
authors.forename: M
authors.initials: M
authors.lastname: Bobrow
mesh_terms: D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D007438:Introns; D008126:Lod Score; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic