Introduction of monoclonal antibodies to bromodeoxyuridine to monitor hepatic regeneration.
The effect on the liver of portal vein and/or bile duct branch ligation was examined in rabbits by measuring cellular kinetics using the bromodeoxyuridine labeling index. Twenty-four days after ligation of a portal vein and/or bile duct branch, similar degrees of compensatory regeneration were observed. However, there were significant differences in the pattern in which regeneration developed. Compensatory regeneration after ligation of a bile duct follows a different pattern than that after portal vein branch ligation.
Nishida
M
M
Department of Surgery II, Yamaguchi University School of Medicine, Japan.
Yano
K
K
Murakami
T
T
Suzuki
T
T
D000818:Animals; D000911:Antibodies, Monoclonal; D001652:Bile Ducts / Q000601:surgery; D001973:Bromodeoxyuridine / Q000276:immunology*; D008026:Ligation; D008115:Liver Regeneration / Q000502:physiology*; D008991:Monitoring, Physiologic; D011169:Portal Vein / Q000601:surgery; D011817:Rabbits
D000911:Antibodies, Monoclonal; D001973:Bromodeoxyuridine