Phosphatidylcholine prevents postoperative peritoneal adhesions: an experimental study in the rat.
Phosphatidylcholine (PC) is the main constituent of the surface-active material coating peritoneal mesothelium. It may prevent postoperative adhesion formation through production of a lubricant film on mesothelial defects. We therefore examined the effect of its soluble form on surgically induced intraabdominal adhesions in rats. The adhesions were induced at laparotomy by any of four different operative models. PC was administered intraperitoneally (20 mg/rat) or intravenously (20 mg/rat or 50 mg/rat) at the end of the operation and on the second and third postoperative day. It was found that the degree of postoperative adhesion formation was significantly reduced by the intraperitoneal injection of PC in all 4 models. In contrast, no effect was achieved by the intravenous injection of PC, not even at a very high dose level. Our results suggest that soluble PC administered intraperitoneally might be a potent adjunct in postoperative adhesion prevention.
Ar'Rajab
A
A
Department of Surgery, Lund University, Sweden.
Ahrén
B
B
Rozga
J
J
Bengmark
S
S
D000005:Abdomen / Q000601:surgery; D000818:Animals; D007274:Injections, Intraperitoneal; D008297:Male; D010532:Peritoneal Diseases / Q000517:prevention & control*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000517:prevention & control*
D010713:Phosphatidylcholines