Ovarian granulosa-stromal cell tumors are characterized by trisomy 12.
Eleven ovarian granulosa-stromal cell tumors including 1 thecoma, 2 fibromas, 6 fibrothecomas, and 2 granulosa cell tumors, were karyotyped after direct harvest and/or short-term tissue culture. Bilateral fibrothecomas from one patient appeared to lack cytogenetic aberrations: the remaining nine tumors were characterized by trisomy for chromosome 12. Cytogenetic aberrations in the two granulosa cell tumors were much less complex than those described previously in undifferentiated carcinomas; accordingly cytogenetic analyses might be useful in distinguishing these categories. The consistent occurrence of trisomy 12 in different varieties of granulosa-stromal cell tumors suggests a common mechanism of oncogenesis within this diverse group of neoplasms. That mechanism probably involves promotion of low-grade, orderly cell proliferation.
Fletcher
J A
JA
Department of Pathology, Brigham and Women's Hospital MA 02115.
Gibas
Z
Z
Donovan
K
K
Perez-Atayde
A
A
Genest
D
D
Morton
C C
CC
Lage
J M
JM
D002881:Chromosomes, Human, Pair 12; D004247:DNA / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006106:Granulosa Cell Tumor / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008677:Metaphase; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011003:Ploidies; D014314:Trisomy
D004247:DNA