Basic and clinical aspects of GnRH-agonists in reproduction.
Within recent years GnRH agonists have gained increasing importance in the treatment of reproductive failure. Their use as a pretreatment for in vitro fertilization increases the pregnancy rate at least under certain conditions. In cases of endometriosis and uterus myomatosus, GnRH agonists achieve high remission rates and may avoid or at least postpone the need for surgical intervention. The physiological basis and current clinical strategies are discussed.
Schmutzler
R K
RK
Department Obstetrics and Gynecology, University of Bonn, FRG.
Diedrich
K
K
D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D007889:Leiomyoma / Q000188:drug therapy; D012098:Reproduction / Q000187:drug effects*; D014594:Uterine Neoplasms / Q000188:drug therapy
D007987:Gonadotropin-Releasing Hormone