Effects of genetic selection on growth rate and intestinal structure in the domestic fowl (Gallus domesticus).
1. Pieces of small intestine taken from chickens subjected previously to continuous selection, relaxed selection or no selection for rapid growth were used to estimate villus surface area and microvillus development to determine what effects genetic selection might have on factors controlling intestinal function. 2. Crypt size and the rates at which enterocytes migrated out of crypts were also measured, after injection of tritiated thymidine, to determine the time course of microvillus elongation. 3. Differences in growth rates measured between highly selected, relaxed selected or unselected birds were found to be correlated with parallel changes in villus surface area. Selection for growth did not change the density, dimensions or pattern of development of enterocyte microvilli. Microvilli did, however, produce a maximal 20-fold increase in villus surface area under all conditions. 4. Crypt size and enterocyte migration rates did not vary significantly between tissue taken from unselected and relaxed selected chickens. Tissue taken from highly selected birds had a crypt size and enterocyte migration rate 40% higher than values found for the other two groups of chickens. 5. The possibility that early genetic selection increased growth potential by uncoupling diet-induced changes on crypt hyperplasia from secondary effects on villus structure, and that later selection increased growth potential by increasing appetite, is discussed.
Smith
M W
MW
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
Mitchell
M A
MA
Peacock
M A
MA
D000818:Animals; D002465:Cell Movement; D002645:Chickens / Q000033:anatomy & histology / Q000235:genetics* / Q000254:growth & development; D005260:Female; D007421:Intestine, Small / Q000033:anatomy & histology* / Q000254:growth & development / Q000502:physiology; D008871:Microvilli / Q000648:ultrastructure; D012641:Selection, Genetic