title: [Extremity-threatening ischemia in ergotism. Successful treatment with the intra-arterial administration of nifedipine].
abstract: A 39-year-old woman suffering from migraine took two suppositories of an ergotamine-containing proprietary drug (Cafergot, containing 2 mg ergotamine tartrate) for the first time again after an abstinence of two years. Twenty-four hours later she developed symptoms of decreased peripheral blood flow in all four limbs. Walking distance without pain was reduced to 100 m, but the severest changes affected the right arm, with livid discolorations and complete immobility 16 hours after the onset of symptoms. Despite administration of morphine derivatives the pain progressively increased. Angiography demonstrated spastic narrowing of all arm arteries below the axillary artery. No vessels were visualized below the lower-arm bifurcation. Thereupon 4 mg nifedipine were injected through the angio-catheter within 30 min (five individual doses of 0.8 mg each). This was followed by intravenous infusion of 0.5 mg/h. The pain immediately decreased and the livid discoloration as well as impaired arm movement improved. A residual deficit, incomplete lesion of the median nerve, persisted but gradually regressed during the following two months.
authors.affiliation: Chirurgische Klinik, Ruhr-Universität Bochum, St. Josef-Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Mumme
authors.forename: R
authors.initials: R
authors.lastname: Ernst
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: K
authors.initials: K
authors.lastname: Schäfer
authors.forename: V
authors.initials: V
authors.lastname: Zumtobel
mesh_terms: D000208:Acute Disease; D000328:Adult; D001132:Arm / Q000098:blood supply* / Q000000981:diagnostic imaging; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004878:Ergotamine / Q000008:administration & dosage / Q000009:adverse effects; D004881:Ergotism / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy; D009543:Nifedipine / Q000008:administration & dosage*; D011859:Radiography; D013488:Suppositories; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D004338:Drug Combinations; D013488:Suppositories; C037330:caffeine, ergotamine drug combination; D002110:Caffeine; D009543:Nifedipine; D004878:Ergotamine