title: Exclusion of autosomal dominant polycystic kidney disease type II (ADPKD2) from 160 cM of chromosome 1.
abstract: Autosomal dominant polycystic kidney disease is a heritable disorder and recent studies have shown genetic heterogeneity, with some, but not all, families showing linkage with markers on chromosome 16p. Members of a large ADPKD family, unlinked to chromosome 16, have been typed for 12 marker loci located on both arms of chromosome 1. Multipoint analysis excluded ADPKD2 from the region between D1S81 (pTHH33) and D1S67 (pHHH106) on the long arm and between Rh and PGM1 on the short arm. This excludes the disease locus from about 61% of chromosome 1.
authors.affiliation: Department of Genetics, Boys Town National Research Hospital, Omaha, Nebraska 68131.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: W J
authors.initials: WJ
authors.lastname: Kimberling
authors.forename: P A
authors.initials: PA
authors.lastname: Gabow
authors.forename: Y Y
authors.initials: YY
authors.lastname: Shugart
authors.forename: S
authors.initials: S
authors.lastname: Pieke-Dahl
mesh_terms: D002878:Chromosomes, Human, Pair 1; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D005819:Genetic Markers