Evaluation of interconversion between (R)- and (S)-enantiomers of beta-aminoisobutyrate.
The conversion of (R)- to (S)-beta-aminoisobutyrate was observed in the presence of D-3-aminoisobutyrate-pyruvate aminotransferase, aminobutyrate aminotransferase, pyruvate and L-glutamate. The reverse reaction was also found in the presence of 2-oxoglutarate and L-alanine. Neither D-3-aminoisobutyrate-pyruvate aminotransferase nor aminobutyrate aminotransferase revealed a racemase activity of the enantiomorphs.
Tamaki
N
N
Laboratory of Nutritional Chemistry, Faculty of Nutrition, Kobe-Gakuin University, Japan.
Kaneko
M
M
Kikugawa
M
M
Fujimoto
S
S
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000409:Alanine / Q000378:metabolism; D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007656:Ketoglutaric Acids / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D013237:Stereoisomerism; D000637:Transaminases / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D005971:Glutamates; D007656:Ketoglutaric Acids; D011773:Pyruvates; D018698:Glutamic Acid; D019289:Pyruvic Acid; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D000409:Alanine; C033435:3-aminoisobutyric acid