Effect of calcium and beta-adrenoceptor antagonists on beta-adrenoceptor density and Gs alpha expression in human atria.
In 21 patients undergoing open heart surgery the effects of the beta-adrenoceptor antagonists propranolol and sotalol and the calcium antagonist nifedipine (alone or in combination) on right atrial beta-adrenoceptor density and G protein expression were studied. The non-selective beta-adrenoceptor antagonists increased both right atrial beta 1- and beta 2-adrenoceptor density; this increase was not affected by nifedipine. There was no correlation between beta-adrenoceptor density and expression of the G protein subunit Gs alpha suggesting independent regulation of the gene expression for G proteins and their coupled receptors.
Jones
C R
CR
Merrell Dow Research Institute, Strasbourg, France.
Fandeleur
P
P
Harris
B
B
Bühler
F R
FR
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000368:Aged; D002118:Calcium / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D012333:RNA, Messenger; D011943:Receptors, Adrenergic, beta; D019204:GTP-Binding Proteins; D002118:Calcium