title: The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis.
abstract: DNA encoding the human aminopeptidase N (EC 3.4.11.2) gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.
authors.affiliation: Department of Physiology, University of Toronto, Ontario, Canada.
authors.forename: V M
authors.initials: VM
authors.lastname: Watt
authors.forename: H F
authors.initials: HF
authors.lastname: Willard
mesh_terms: D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D018826:CD13 Antigens; D002478:Cells, Cultured; D002884:Chromosomes, Human, Pair 15; D004247:DNA / Q000302:isolation & purification*; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D015183:Restriction Mapping
chemical_list: D004247:DNA; D000626:Aminopeptidases; D018826:CD13 Antigens