[Liposomal systems--prospective drug forms. II. The creation and characterization of liposomal systems for the oral use of narcotic analgesics].
Liposomal systems were prepared for oral usage of narcotic analgesics morphine and phentanyl. The systems were examined for homogeneity in respect to seize size and form of liposomal structures by a diffraction-laser method and electron microscopy. The liposomal drug forms were studied on biological experiment as the change in the body temperature of rats was described. It was established that in rats oral usage of liposomal systems with morphine respectively with phentanyl caused significantly better effect in comparison with active substances, not taken in liposomes.
Mikhaĭlova
S
S
Iakimova
K
K
D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000818:Animals; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005283:Fentanyl / Q000008:administration & dosage; D008081:Liposomes / Q000737:chemistry; D008297:Male; D008855:Microscopy, Electron, Scanning; D009020:Morphine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains
D000701:Analgesics, Opioid; D004337:Drug Carriers; D008081:Liposomes; D009020:Morphine; D005283:Fentanyl