title: Impedance measurement of absolute blood flow using an angioplasty catheter: a validation study.
abstract: An angioplasty catheter was developed to allow measurement of absolute coronary blood flow during interventional procedures. This method uses electrical impedance changes induced by a 0.5 ml bolus of 5% dextrose solution and indicator-dilution principles. The indicator is injected through a port located just proximal to the dilating balloon and the resulting changes in blood impedance are measured by electrodes at the catheter tip. Excellent linear correlations were found between known flow in 2 to 4 mm to diameter plastic tubes and catheter measurements (r = 0.99) and between timed collection canine femoral artery flow and catheter measurements (r = 0.97). Final validation was performed in canine coronary arteries using electromagnetic flowmeter data as the standard (r = 0.94). Thus accurate clinical determination of absolute coronary blood flow can be accomplished using this relatively inexpensive and simple catheter technique.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore.
authors.forename: L W
authors.initials: LW
authors.lastname: Martin
authors.forename: R A
authors.initials: RA
authors.lastname: Johnson
authors.forename: H
authors.initials: H
authors.lastname: Scott
authors.forename: S
authors.initials: S
authors.lastname: Robinson
authors.forename: G
authors.initials: G
authors.lastname: Beauman
authors.forename: M
authors.initials: M
authors.lastname: Englehardt
authors.forename: R A
authors.initials: RA
authors.lastname: Vogel
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D004553:Electric Conductivity; D004867:Equipment Design; D005263:Femoral Artery; D005947:Glucose; D007201:Indicator Dilution Techniques; D008839:Microelectrodes; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results
chemical_list: D005947:Glucose