[The correlation of the serotonin-positive and anxiolytic activities of nonbenzodiazepine substances].
The anxiolytic activity of serotonin agonists (buspirone, ipsapirone, campirone, caplapirone, 1-pyrimidinyl-piperazine) determined in rats on 3 experimental models of anxiety closely correlates with the degree of inhibition of impulse release of 3H-serotonin by electrically stimulated slices of the midbrain raphe dorsal nucleus (r = +0.85) but not the slices of the cerebral hemispheric cortex (r = +0.60) of the rats. The anxiolytic activity of neuroleptics (chlorpromazine, trifluorperazine), antidepressant (amitriptyline, imipramine) and beta-carbolines (harmane, 3.4-tetramethyleneharmane) corresponds well (r = +0.94) to the ability of the drugs to potentiate the hyperpolarizing effects of serotonin in the rat sensory ganglion.
Abramets
I I
II
Dolzhenko
A T
AT
Komissarov
I V
IV
Samoĭlovich
I M
IM
Talalaenko
A N
AN
Kharin
N A
NA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin