Differential development of angiotensin II receptor subtypes in the rat brain.
Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.
Tsutsumi
K
K
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Saavedra
J M
JM
D000375:Aging; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology; D007700:Kinetics; D019808:Losartan; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D007093:Imidazoles; D009842:Oligopeptides; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; C060894:CGP 42112A; D019808:Losartan