title: Starvation as an inducer of error-free DNA repair in Escherichia coli.
abstract: Previous work in this laboratory has shown that heat shock or vitamin B1 deprivation induces an error-free DNA-repair process in Escherichia coli. The system is absolutely dependent on excision repair, while its induction is delayed in lon- or recA- cells. We have now shown that starvation of E. coli for amino acids, glucose or phosphate, conditions known to induce the stringent response or the glu and pho regulons, respectively, leads to a similar uvrA-dependent increase in UV resistance and decrease in UV-induced mutation frequency. These results support the hypothesis that the effect is a general response to non-mutagenic stress that may play an important role in the survival of cells exposed to harsh environments.
authors.affiliation: Department of Biochemistry, University of Ottawa, Ont., Canada.
authors.forename: P S
authors.initials: PS
authors.lastname: Fitt
authors.forename: N
authors.initials: N
authors.lastname: Sharma
mesh_terms: D000596:Amino Acids / Q000172:deficiency; D004260:DNA Repair / Q000502:physiology*; D004269:DNA, Bacterial / Q000502:physiology* / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics*; D005947:Glucose / Q000172:deficiency; D009154:Mutation; D010710:Phosphates / Q000172:deficiency; D014466:Ultraviolet Rays
chemical_list: D000596:Amino Acids; D004269:DNA, Bacterial; D010710:Phosphates; D005947:Glucose