Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9.
Recombinant inbred strains of mice were used to localize the genes coding for the class alpha glutathione S-transferase 2 (Gst-2). The genes showed three distinct strain distribution patterns, indicating that they occur in at least three clusters separable by recombination. All three clusters are located in the vicinity of the d locus on mouse chromosome 9, but two of them are closer to d than the third. Linked to Gst-2 on mouse chromosome 9 are two enzyme-encoding loci, Pgm-3 and Mod-1. The human counterparts of Gst-2, Pgm-3, and Mod-1 map to 6p12, 6q12, and 6q12, respectively. Thus, the pericentric region of human chromosome 6 has its homolog in the segment spanning Gst-2, Pgm-3, and Mod-1 on mouse chromosome 9. The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarhini.
Kasahara
M
M
Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101.
Matsumura
E
E
Webb
G
G
Board
P G
PG
Figueroa
F
F
Klein
J
J
D000818:Animals; D005075:Biological Evolution; D015139:Blotting, Southern; D002874:Chromosome Mapping; D015342:DNA Probes; D005982:Glutathione Transferase / Q000145:classification / Q000235:genetics*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
D015342:DNA Probes; D005982:Glutathione Transferase