title: Ewing's sarcoma. Prognostic factors, disease control, and the reemerging role of surgical treatment.
abstract: Advances in the treatment of Ewing's sarcoma have been dramatic. Present treatment protocols control local disease by radiotherapy, surgery, or both; systemic spread is limited by aggressive multiagent chemotherapy. In patients with localized osseous Ewing's sarcoma, five-year survival rates now range from 54% to an estimated 74%. With late relapse not uncommon, control of the primary lesion is critical to long-term survival. Several studies now show improved local control and possibly improved survival of patients with surgical treatment of primary osseous Ewing's sarcoma.
authors.affiliation: Mayo Graduate School of Medicine, Mayo Clinic, Rochester, MN 55905.
authors.forename: M I
authors.initials: MI
authors.lastname: O'Connor
authors.forename: D J
authors.initials: DJ
authors.lastname: Pritchard
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011859:Radiography; D011879:Radiotherapy Dosage; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000628:therapy*