title: Immunohistochemical studies of S-100 protein alpha and beta subunits in adenoid cystic carcinoma of salivary glands.
abstract: Immunohistochemical studies were performed to explore the distribution of S-100 protein and its alpha, beta subunits in 76 adenoid cystic carcinomas (ACC) of the salivary glands. Histopathologically. ACC was divided into cribriform, tubular, basaloid and trabecular types which could be mixed in the same tumor. S-100 protein was usually positive in tumor cells forming cribriform structures; foci of strongly positive tumor cells were also distributed in the luminal layer of tubular structures, and in areas transitional between cribriform and tubular patterns. S-100 alpha staining was confined to some tumor cells in cribriform areas, to luminal tumor cells in tubular structures and to few tumor cells in basaloid structures. S-100 beta reaction was usually localized to luminal surfaces in a fine granular pattern in tubular and microtubular structures in a distribution somewhat similar to that in the normal salivary gland. Great heterogeneity in the immunohistochemical distribution of S-100, S-100 alpha and S-100 beta proteins was found in the various histologic types of ACC and the pattern was different from that seen in pleomorphic adenomas. It is possible that the ACC tumor cells positive for S-100 protein may be closely related to true or modified myoepithelial cells.
authors.affiliation: Department of Oral-Maxillofacial Surgery, Asahi University School of Dentistry, Gifu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Kasai
authors.forename: R
authors.initials: R
authors.lastname: Yuba
authors.forename: G
authors.initials: G
authors.lastname: Chomette
authors.forename: M
authors.initials: M
authors.lastname: Auriol
authors.forename: J M
authors.initials: JM
authors.lastname: Vaillant
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009418:S100 Proteins / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D009418:S100 Proteins