Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats.
Although (+/-) methylenedioxymethamphetamine (MDMA) has been reported to deplete serotonin (5-HT) and destroy 5-HT terminals in the brains of animals, the functional sequelae of such alterations remain to be established. In the present study, a blunted corticotropin and an enhanced prolactin response to the 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH DPAT) was found in rats treated two weeks previously with a single dose of MDMA (2.0 or 20.0 mg/kg, sc). These results suggest that neurochemical changes produced by MDMA are associated with functional alterations as manifested by abnormal 5-HT receptor-coupled neuroendocrine responses.
Poland
R E
RE
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509.
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004347:Drug Interactions; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D015104:3,4-Methylenedioxyamphetamine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D018817:N-Methyl-3,4-methylenedioxyamphetamine