Effects of qing-fei-tang on the airway inflammation and clearance.
Qing-Fei-Tang, a Chinese blended medicine, inhibited the release of slow reacting substance of anaphylaxis (SRS-A) from passively sensitized guinea pig lung after antigen challenge. Qing-Fei-Tang also suppressed the chemiluminescence of oxygen radicals when healthy human leukocytes were stimulated by opsonized zymosan. In rabbits, Qing-Fei-Tang increased the output volume and fatty acid contents in respiratory tract fluid. In the bronchitic rabbits, 6 weeks administration of Qing-Fei-Tang restored the decreased amount of saturated fatty acid in the sputa, and histological examinations revealed an amelioration of the inflammation of lung tissues. In pigeons, Qing-Fei-Tang facilitated tracheal mucociliary transport. Accordingly, Qing-Fei-Tang seems to exert effectiveness via its multiple mechanisms.
Miyamoto
K
K
Department of Pharmacology, Fukuoka University, Japan.
Furusawa
K
K
Kuroiwa
A
A
Saito
M
M
Miyata
T
T
Furukawa
T
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012898:Autacoids / Q000378:metabolism*; D001991:Bronchitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D010856:Columbidae; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000378:metabolism; D013183:Sputum / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D012898:Autacoids; D004365:Drugs, Chinese Herbal