[The effect of narcotic analgetic fenaridine and narcotic antagonist FI on the level of cyclic nucleotides in the brain of albino rats].
Content of cAMP and cGMP was estimated in rat brain corpus striatum after treatment with narcotic analgetic fenaridin and antagonist of narcotic analgetics F1 which are similar chemically. Various concentrations of fenaridin increased the cAMP content, whereas that of cGMP was not altered. At the same time, administration of the antagonist of narcotic analgetics F1 led to an increase in content of cGMP and to a distinct elevation of cAMP content.
Vartanian
G S
GS
Burnazian
R A
RA
Agadzhanov
M I
MI
D015761:4-Aminopyridine / Q000031:analogs & derivatives*; D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D000701:Analgesics, Opioid; D001565:Benzoates; D009292:Narcotic Antagonists; C006003:N-benzoyl-N'-phenyl-2,6-diaminobenzoic acid; D015761:4-Aminopyridine; D000242:Cyclic AMP; D006152:Cyclic GMP; C054783:phenaridine