Aerial oxidation of hydrazines to nitrosamines.
When 1,1-dimethylhydrazine and N-aminopiperidine were deliberately exposed to air substantial amounts of the corresponding carcinogenic nitrosamines were formed. Unoxidized samples of 1,1-dimethylhydrazine were not mutagenic while oxidized samples (which contained much higher levels of nitrosamines) were mutagenic. Both unoxidized and oxidized samples of N-aminopiperidine were mutagenic.
Lunn
G
G
Environmental Control and Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702-1201.
Sansone
E B
EB
Andrews
A W
AW
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D006224:Cricetinae; D004127:Dimethylhydrazines / Q000737:chemistry* / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry*; D008297:Male; D008647:Mesocricetus; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry*; D009602:Nitrosamines; D010084:Oxidation-Reduction; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D004127:Dimethylhydrazines; D006834:Hydrazines; D009153:Mutagens; D009602:Nitrosamines; D010880:Piperidines; C034628:N-aminopiperidine; D019813:1,2-Dimethylhydrazine