Comparison of cetirizine with astemizole in the treatment of perennial allergic rhinitis and study of the concomitant effect on histamine and allergen-induced wheal responses.
Thirty patients suffering from perennial allergic rhinitis took astemizole and cetirizine, 10 mg/d, under double-blind, crossover randomized conditions for 4 weeks. Four weeks washout separated the two periods. Nasal condition was improved, histamine and allergen-induced wheal responses were inhibited by both treatments with a slight advantage for cetirizine. Both treatments were well tolerated.
Lobaton
P
P
UCB, Secteur Pharmaceutique, Braine-l'Alleud, Belgium.
Moreno
F
F
Coulie
P
P
D000328:Adult; D016589:Astemizole; D001562:Benzimidazoles / Q000627:therapeutic use*; D017332:Cetirizine; D004311:Double-Blind Method; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D012882:Skin Tests; D014581:Urticaria / Q000276:immunology*
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D016589:Astemizole; D017332:Cetirizine