title: Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid.
abstract: Recent data have generated some interest in technetium-99m-(99mTc) glucaric acid as an in vivo viability marker. We studied 99mTc-glucaric acid retention in canine models of myocardial ischemia (20-min occlusion of the LAD/40-min reperfusion), acute myocardial infarction (MI) (90-min LAD occlusion/3-hr reperfusion), and chronic MI (90-min occlusion and either 48-hr or 10-day reperfusion). Regional myocardial blood flow was measured by radiolabeled microspheres. No preferential uptake of glucaric acid was observed in ischemic but viable myocardium. The compound showed high affinity for necrotic myocardial tissue for several days following injury. The preferential uptake in infarcted tissue disappeared by 10 days following injury. This study shows that 99mTc-glucaric acid acts exclusively as a marker of necrosis in canine models of MI. Technetium-99m-glucaric acid may have clinical utility in early cardiac imaging of myocardial infarction and in differentiating recent from old injuries.
authors.affiliation: Medical Products Department, E.I. du Pont de Nemours & Co., North Billerica, MA 01862.
authors.forename: C
authors.initials: C
authors.lastname: Orlandi
authors.forename: P D
authors.initials: PD
authors.lastname: Crane
authors.forename: D S
authors.initials: DS
authors.lastname: Edwards
authors.forename: S H
authors.initials: SH
authors.lastname: Platts
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Lazewatsky
authors.forename: M J
authors.initials: MJ
authors.lastname: Thoolen
mesh_terms: D000818:Animals; D004285:Dogs; D005937:Glucaric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006168:Guinea Pigs; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; C067171:technetium Tc 99m glucarate; D005937:Glucaric Acid