title: T-cell subsets with a naive phenotype are selectively decreased in the peripheral blood of patients with mycosis fungoides.
abstract: Peripheral blood lymphocytes of 33 patients with histopathologic confirmation of mycosis fungoides and 27 healthy controls matched for age and sex were analyzed with a panel of monoclonal antibodies using both single and dual color immunofluorescence. Patients with mycosis fungoides had a significant reduction in the percentage of circulating T cells with a naive phenotype (i.e., CD4+2H4+ and CD4+Leu8+), as well as a significant reduction in the absolute numbers of circulating lymphocytes with the phenotype CD8+Leu8+ compared to the control cohort. The reduction in circulating naive T cells was found to occur irrespective of stage of disease, duration of disease, or mode of treatment. The depletion of circulating naive T cells may reflect increased conversion to memory T cells in the peripheral blood or skin.
authors.affiliation: Department of Pathology, Monash University, Melbourne, Australia.
authors.forename: S J
authors.initials: SJ
authors.lastname: Gilmore
authors.forename: E M
authors.initials: EM
authors.lastname: Benson
authors.forename: J W
authors.initials: JW
authors.lastname: Kelly
mesh_terms: D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000097:blood / Q000276:immunology* / Q000473:pathology; D009367:Neoplasm Staging; D010641:Phenotype; D012016:Reference Values; D012878:Skin Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000954:Antigens, Surface