title: "Paradoxical" growth hormone secretion in acromegaly: an avian model?
abstract: Acromegaly is a pathological human condition resulting from an excess of growth hormone (GH) secretion in adults. The regulation of GH secretion in acromegalics is characterised by "paradoxical" GH responses to dynamic tests of pituitary GH function. Many of these "paradoxical" responses appear to be normal, physiological GH responses in aves. Comparative studies on the control of GH secretion in immature birds may therefore provide an experimental model for testing the effects of therapeutic agents of GH secretion.
authors.affiliation: Department of Physiology, University of Alberta, Edmonton, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Harvey
mesh_terms: D000172:Acromegaly / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone