[A comparative evaluation of the efficacy and tolerance of gold and D-penicillamine preparations in patients with rheumatoid arthritis. II. The effect on the morphological indices of rheumatoid synovitis].
Morphological signs of rheumatoid synovitis have been analysed on the basis of 130 puncture biopsies taken from 46 patients prior to the beginning and during parenteral therapy with auric preparations (crysanolom and myocrysin) and peroral administration of an auric preparation rhidaura and small doses of D-penicillamine. The most marked morphological effect was reached in 1.5 years. With a favourable clinical effect all the preparations exhibited capacity for suppressing the following basic signs of rheumatoid synovitis: proliferative changes in the layer of synoviocytes, reaction of blast cells.
Shekhter
A B
AB
Slobodina
G A
GA
Krel'
A A
AA
Kanevskaia
M Z
MZ
Chichasova
N V
NV
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050607:Organogold Compounds; D010396:Penicillamine / Q000627:therapeutic use*; D013585:Synovitis / Q000188:drug therapy* / Q000473:pathology
D018501:Antirheumatic Agents; D050607:Organogold Compounds; D010396:Penicillamine