The pharmacology of new anxiolytics acting on 5-HT neurones.
This paper discusses the alternative approaches available for the development of anxiolytics not acting on the benzodiazepine--GABA receptor complex. There are now several compounds that work by reducing 5-hydroxytryptamine function in the brain that have been shown to have anxiolytic properties in animals and in some cases man. Detailed long-term clinical trials are required to determine whether these new drugs are clinically useful and avoid the problems associated with benzodiazepines.
Marsden
C A
CA
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D006801:Humans; D009474:Neurons / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D011985:Receptors, Serotonin