Folic acid analogues lacking the 2-carbon are substrates for folylpolyglutamate synthetase and inhibit cell growth.
Rosowsky
A
A
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
Forsch
R A
RA
Moran
R G
RG
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005492:Folic Acid / Q000031:analogs & derivatives*; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D007202:Indicators and Reagents; D007700:Kinetics; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D010453:Peptide Synthases / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D007202:Indicators and Reagents; D005492:Folic Acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase