T-cell depletion for bone marrow transplantation: effects on graft rejection, graft-versus-host disease, graft-versus-leukemia, and survival.
T-cell depletion of the donor bone marrow offers the most effective approach yet reported to prevent graft-versus-host disease and its associated mortality. This approach has allowed histoincompatible bone marrow transplants for children with immunodeficiency states. It has been more difficult to apply T-cell depletion to bone marrow transplants for leukemia. Failure of engraftment and leukemia relapse are more frequent than with transplants of unmodified bone marrow. Hopefully more effective immunosuppressive and antileukemic preparative regimens can be developed to allow successful application of T-cell-depleted transplants and effective prevention of graft-versus-host disease.
Champlin
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D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002648:Child; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D008212:Lymphocyte Depletion; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control*; D012008:Recurrence; D013601:T-Lymphocytes / Q000166:cytology*