Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol: interaction with the cholinergic neuronal system.
We examined the involvement of GABAergic neuronal systems in benzodiazepine-induced passive avoidance deficit. Chlordiazepoxide impaired the passive avoidance response dose dependently when it was given prior to training. Post-training administration of muscimol improved the performance of chlordiazepoxide-pretreated mice. The effects of muscimol were antagonized completely by the GABAA antagonist, bicuculline, and the muscarinic acetylcholine receptor antagonist, scopolamine, but not by the benzodiazepine receptor antagonist, flumazenil, when the latter was administered immediately after training. It appears from these results that the GABAergic neuronal system plays an important role in the benzodiazepine-induced passive avoidance deficit by interacting with the cholinergic neuronal system.
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Tohyama
K
K
Ichihara
K
K
Kameyama
T
T
D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology; D002707:Chlordiazepoxide; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009118:Muscimol / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D009118:Muscimol; D005442:Flumazenil; D002707:Chlordiazepoxide; D012601:Scopolamine; D001640:Bicuculline