Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping.
The human vimentin gene and a random DNA segment (D10S39) were mapped to the short arm of human chromosome 10 by linkage analysis. A panel of somatic cell hybrids and monosomy cell-lines, which divide chromosome 10 into seven regions, was used to localize 10 polymorphic markers on this chromosome. The physical map locations obtained correlate well with linkage maps of chromosome 10. Two markers which have been shown to be closely linked to the gene for multiple endocrine neoplasia type 2A map distal to a translocation breakpoint in band 10q11.2.
Mathew
C G
CG
Department of Pathology, University of Cambridge, UK.
Wakeling
W
W
Jones
E
E
Easton
D
D
Fisher
R
R
Strong
C
C
Smith
B
B
Chin
K
K
Little
P
P
Nakamura
Y
Y
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D006224:Cricetinae; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008126:Lod Score; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers