title: Effects of enucleation on postnatal development of catecholamines and serotonin metabolism in the superior colliculus of the rat.
abstract: We have measured the level of catecholamines and serotonin and their principal metabolites, and the activities of tyrosine hydroxylase, tryptophan hydroxylase and monoamine oxidase-A and -B in the rat superior colliculus during postnatal development after bilateral removal of the eyes. The visual deprivation has different effects on the catecholamines and serotonin metabolism. The major changes in both amines were at day 15. Tyrosine hydroxylase and tryptophan hydroxylase activities increased during postnatal development but this increase was higher in enucleated compared with controls. An increase of the MAO-B to MAO-A ratio during postnatal development was found. The significance of these changes has been discussed.
authors.affiliation: Departamento de Bioquímica, Bromatología y Toxicología, Universidad de Sevilla, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Vizuete
authors.forename: A J
authors.initials: AJ
authors.lastname: Herrera
authors.forename: M
authors.initials: M
authors.lastname: Santiago
authors.forename: A
authors.initials: A
authors.lastname: Machado
authors.forename: J
authors.initials: J
authors.lastname: Cano
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004298:Dopamine / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013477:Superior Colliculi / Q000254:growth & development / Q000502:physiology*; D014365:Tryptophan Hydroxylase / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D007527:Isoenzymes; D012701:Serotonin; D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine