title: Follow-up study of thyroid stimulating-blocking antibodies in hypothyroid patients.
abstract: It has been shown that hypothyroidism of some patients may be associated with increased activity of thyroid stimulating-blocking antibodies (TSBAb). The present study was undertaken to follow the course of thyroid blocking, stimulating immunoglobulins and TSH-binding inhibitor immunoglobulins (TBII) in six hypothyroid patients who had elevated TSBAb and were treated with T4. Four of the six had Graves' disease previously treated with antithyroidal drugs, one had Graves' disease treated with 131I and one had subacute thyroiditis and subsequently became hypothyroid. The patients were followed for 1-5 years. Blocking activity and TBII normalized in four of the six during T4 therapy, so T4 was discontinued and they remained euthyroid. These data indicate that it is important to monitor carefully thyroid function in hypothyroid patients treated with a fixed amount of T4 to avoid subclinical hyperthyroidism and its consequence, e.g. osteoporosis.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: A
authors.initials: A
authors.lastname: Hidaka
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: J
authors.initials: J
authors.lastname: Konishi
authors.forename: L F
authors.initials: LF
authors.lastname: Kumagai
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000628:therapy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D013961:Thyroid Gland / Q000276:immunology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D013974:Thyroxine