Acute dystonic reaction in normal humans caused by catecholamine depletion.
Five of 24 (21%) normal men (volunteers) administered alpha-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.
McCann
U D
UD
Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Penetar
D M
DM
Belenky
G
G
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D004421:Dystonia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000009:adverse effects*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D014446:Tyrosine 3-Monooxygenase