5HT3-antagonist receptors: their role in drug-induced emesis.
Chemotherapy-induced emesis is the most severe side effect in term of patient's perception. Current anti-emetic regimen as high dose metoclopramide can achieve a complete response in less than 60% of patients. The HT3 receptors appear to be the principal mediator of the emetic effect and their blockade have a clear activity in the prevention of acute drug-induced emesis, superior to reference regimens.
Dieras
V
V
Service de Médecine Oncologique, Paris, France.
Extra
J M
JM
Le Bonniec
M
M
Madelaine
I
I
Espie
M
M
Marty
M
M
D000932:Antiemetics / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D018492:Dopamine Antagonists; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D008787:Metoclopramide / Q000494:pharmacology / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D000932:Antiemetics; D000970:Antineoplastic Agents; D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D003907:Dexamethasone; D008787:Metoclopramide