title: The Xenopus laevis Hox 2.1 homeodomain protein is expressed in a narrow band of the hindbrain.
abstract: The expression pattern of the Xenopus homeodomain protein Hox 2.1 during development was determined using an affinity-purified antibody directed against a carboxyterminal peptide. Nuclear staining was detected in a very narrow band of the hindbrain. This pattern was compared to that of the previously described Xenopus gene XIHbox 1 in serial sections and found to be more anterior than the XIHbox 1 long protein expression but overlapping with that of the short protein. Xenopus Hox 2.1 protein expression is restricted to a much narrower antero-posterior band than that reported for mouse Hox 2.1 RNA expression by in situ hybridization.
authors.affiliation: Department of Biological Chemistry, University of California School of Medicine, Los Angeles 90024-1737.
authors.forename: B G
authors.initials: BG
authors.lastname: Jegalian
authors.forename: E M
authors.initials: EM
authors.lastname: De Robertis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005801:Genes, Homeobox; D018398:Homeodomain Proteins; D007158:Immunologic Techniques; D008969:Molecular Sequence Data; D009024:Morphogenesis; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology*
chemical_list: D004268:DNA-Binding Proteins; C489125:HOXB5 protein, Xenopus; D018398:Homeodomain Proteins; D010446:Peptide Fragments; D029867:Xenopus Proteins