[Magnesium sulfate as adjuvant in beta-2-sympathicomimetic inhalation therapy of bronchial asthma].
The protective effects of inhaled MgS04 on exercise-induced asthma were studied in 13 children aged 6-13 years. The patients performed 6 min. running test on 3 separate days. Spirometry (FEV1, SRAW, VK, PF) was recorded on each test day 10 min. after medicament inhalation directly before and instantly, 2, 5, 10 and 20 min after the running test. t-tests on the mean revealed no significant effects on spirometric measurements (p less than 0.1), but in 6 patients MgS04-inhalation prevented FEV1--decreases greater than 20%. The combination gave better protection compared to salbutamol alone demonstrated from the measurements after exercise testing. Thus, MgS04-inhalation could be useful in the protective treatment of asthma.
Manzke
H
H
Kinderkrankenhaus Seehospiz, Kaiserin Friedrich, Norderney.
Thiemeier
M
M
Elster
P
P
Lemke
J
J
D000280:Administration, Inhalation; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D005080:Exercise Test; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D013147:Spirometry
D000318:Adrenergic beta-Agonists; D008278:Magnesium Sulfate