Somatostatin and epilepsy.
Hippocampal neurons containing somatostatin have been shown to be vulnerable in some experimental models of epilepsy. In this report, we describe our recent findings about the seizure-related changes in somatostatin in brain tissue and cerebrospinal fluid (CSF) in experimental and human epilepsy. These data strengthen the view that the somatostatinergic system is affected in epilepsy.
Riekkinen
P J
PJ
Department of Neurology, University of Kuopio, Finland.
Pitkänen
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D004827:Epilepsy / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000134:cerebrospinal fluid / Q000378:metabolism; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000134:cerebrospinal fluid / Q000378:metabolism*
D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin