title: Normative data for lumbar spine bone mineral content in children: influence of age, height, weight, and pubertal stage.
abstract: In 136 normal growing children between the ages of 1 and 18 yr, bone mineral content (BMC) at the level of the lumbar spine (L2-L4) was determined with a commercial dual-photon absorptiometer. BMC was calculated as BML (BMC per unit length) and BMD (BMC per unit surface). The mean lumbar spine BML of the studied children (2.53 +/- 0.86 gHA/cm) was significantly lower than the spinal mineral content of adults (4.26 +/- 0.57 gHA/cm). No sex difference existed in lumbar spine BMC. BML as well as BMD were highly dependent on age, body height, and body weight. During the prepubertal years, BML and BMD increased in a fairly rectilinear pattern. During puberty, BMC increased more rapidly: 40% for BMD and 77% for BML. For the entire group, the increase in BMC with age, height, and weight was best predicted by an exponential regression line analysis.
authors.affiliation: Department of Pediatrics, Akademisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: De Schepper
authors.forename: M P
authors.initials: MP
authors.lastname: Derde
authors.forename: M
authors.initials: M
authors.lastname: Van den Broeck
authors.forename: A
authors.initials: A
authors.lastname: Piepsz
authors.forename: M H
authors.initials: MH
authors.lastname: Jonckheer
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000375:Aging / Q000502:physiology*; D001827:Body Height / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008159:Lumbar Vertebrae / Q000502:physiology*; D008297:Male; D011627:Puberty / Q000502:physiology*; D012016:Reference Values