[Prevention of adhesions in abdominal surgery. A dose finding study with streptokinase/streptodornase].
Measurement of intraperitoneal fibrinolytic activity on 50 patients having undergone abdominal surgery (four of them controls). Instillation of streptokinase/streptodornase (Varidase) into the abdominal cavity. Determination of total protein, plasminogen, antiplasmin, alpha 2 Mx-plasmin-complex, spontaneous fibrinolysis and fibrinolysis + activator at different points in time p.op.


RESULTS
Intraperitoneal fibrinolysis may be stimulated by local substitution of a plasminogen activator (Varidase). Systemic effects are confined to a high dose. No impaired wound healing nor increased propensity to hemorrhaging occurred.
Tuchmann
A
A
I. Chirurgische Abteilung KA Rudolfstiftung Wien.
Dinstl
K
K
Depisch
D
D
Wendt
P
P
Blümel
G
G
D000005:Abdomen / Q000601:surgery*; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D010533:Peritoneal Lavage; D011183:Postoperative Complications / Q000517:prevention & control*; D013299:Streptodornase and Streptokinase / Q000008:administration & dosage* / Q000009:adverse effects; D000267:Tissue Adhesions / Q000517:prevention & control*
D013299:Streptodornase and Streptokinase