title: [The clinical course of allergic diseases in children and the T-lymphocyte dynamics with adsorbed DT-m vaccination against a background of drug therapy].
abstract: In case of immunization with adsorbed diphtheria-tetanus toxoid with reduced antigen content the treatment of children with calcium pantothenate in combination with chloropyramine proved to be most effective. This was confirmed by the absence of postvaccinal complications and by the most active restoration of the pool of active T cells as early as 2 months after immunization. After the preliminary treatment of children with allergic diseases with calcium pantothenate, glyceram, chloropyramine or their combinations the number of T lymphocytes decreased differently in children receiving different medicinal preparations. In 2 months after immunization the restoration of the pool of T cells was incomplete in children with allergic diseases and considerably more intensive in healthy children.
authors.forename: O E
authors.initials: OE
authors.lastname: Fedorova
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D004168:Diphtheria Toxoid / Q000627:therapeutic use*; D022422:Diphtheria-Tetanus Vaccine; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005029:Ethylenediamines / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007958:Leukocyte Count / Q000187:drug effects; D010205:Pantothenic Acid / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013745:Tetanus Toxoid / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D013745:Tetanus Toxoid; D010205:Pantothenic Acid; C004664:chloropyramine