title: Antihistaminic activity of pulegone on the guinea-pig ileum.
abstract: Pulegone, a natural monoterpene compound, has an antihistamine effect on guinea-pig ileum. Its antagonism is of the competitive type (PA2 = 6.35) like that of mepyramine and dexchlorpheniramine, two H1-antagonists, with PA2 values of 10.15 and 8.74, respectively.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
authors.forename: A V
authors.initials: AV
authors.lastname: Ortiz de Urbina
authors.forename: M L
authors.initials: ML
authors.lastname: Martin
authors.forename: M J
authors.initials: MJ
authors.lastname: Montero
authors.forename: R
authors.initials: R
authors.lastname: Carron
authors.forename: M A
authors.initials: MA
authors.lastname: Sevilla
authors.forename: L
authors.initials: L
authors.lastname: San Roman
mesh_terms: D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D000081005:Cyclohexane Monoterpenes; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives* / Q000494:pharmacology; D039821:Monoterpenes; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology
chemical_list: D000081005:Cyclohexane Monoterpenes; D006633:Histamine Antagonists; D039821:Monoterpenes; D008610:Menthol; D002744:Chlorpheniramine; C039648:pulegone; D011738:Pyrilamine