Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.
Previously, it has been shown that E mu-pim-1 transgenic mice are predisposed to T-cell lymphomas, whereas E mu-myc transgenic mice are predisposed to pre-B-cell lymphomas. Here we show that double-transgenic E mu-myc E mu-pim-1 mice exhibit pre-B-cell leukemia in utero. Upon transplantation into recipient mice, embryo-derived double-transgenic leukemic cells frequently progressed to highly malignant monoclonal tumors, indicating that additional (epi)genetic events had occurred during the progression of the disease.
Verbeek
S
S
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam.
van Lohuizen
M
M
van der Valk
M
M
Domen
J
J
Kraal
G
G
Berns
A
A
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005333:Fetus; D016259:Genes, myc; D015448:Leukemia, B-Cell / Q000196:embryology / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D009857:Oncogenes