Glycine facilitates induction of long-term potentiation of evoked potential in rat hippocampus.
Effects of glycine were investigated in Schaffer/commissural-CA1 pyramidal cell synapses of the rat hippocampal slices. Perfusion of glycine (0.05 mM) did not change baseline population spikes evoked by test stimulation but significantly enhanced short-term potentiation induced by a single shorter tetanus (100 Hz, 11 impulses); the effects resulted in production of long-term potentiation (LTP). LTP produced by a longer tetanus (100 Hz, 100 impulses, 2 trains) was not significantly influenced. Higher concentration (0.5 mM) of glycine increased the baseline spike amplitude. All these effects of glycine were not observed in the presence of 10(-5) M 2-amino-5-phosphonovalerate, an N-methyl-D-aspartate (NMDA) antagonist. These results demonstrate that glycine can facilitate induction of LTP probably by activating NMDA receptor.
Abe
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Xie
F J
FJ
Watanabe
Y
Y
Saito
H
H
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D005998:Glycine