Genetic changes in somatostatin receptor positive breast tumors.
Forty-nine primary breast tumors were analyzed for the expression of the somatostatin receptor (SSR) and genetic changes in the RB tumor suppressor gene. Twenty-four tumor samples were shown to contain receptors for somatostatin and in eight of these SSR-positive tumors we observed a mutation in the RB gene. However, since also in the group of SSR-negative tumors in eight of the 25 cases an alteration of the RB gene was observed, loss of this tumor suppressor gene is not specific for the SSR-positive subgroup of breast tumors. A similar, equal distribution between SSR-positive and SSR-negative breast tumors was observed for the six tumor samples which showed amplification of the neu proto-oncogene.
Bootsma
A H
AH
Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands.
de Klein
A
A
Reubi
J C
JC
Zwarthoff
E C
EC
Lamberts
S W
SW
D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D017981:Receptors, Neurotransmitter / Q000096:biosynthesis / Q000235:genetics*; D017481:Receptors, Somatostatin; D012175:Retinoblastoma / Q000235:genetics*; D013004:Somatostatin / Q000378:metabolism
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin