title: Risk of human immunodeficiency virus (HIV) transmission by blood transfusions before the implementation of HIV-1 antibody screening. The Transfusion Safety Study Group.
abstract: Little information is available regarding the risk of human immunodeficiency virus type 1 (HIV-1) infection for patients transfused before routine anti-HIV-1 screening of blood donors was instituted in March 1985. A model was developed for estimating both the proportion and the number of transfusion recipients in the San Francisco Bay area who were infected by HIV-1 during each of the 7 years preceding routine donor screening for anti-HIV-1. The model is based on analysis of 1) donation histories of HIV-1-infected donors identified at the regional blood center; 2) HIV-1 seroprevalence estimates for homosexual and bisexual men in San Francisco; and 3) HIV-1 infection and survival rates for recipients traced by the Transfusion Safety Study and Irwin Memorial Blood Centers' Look Back Program. The incidence of transfusion-associated HIV-1 infection is estimated to have risen rapidly from the first occurrence in 1978 to a peak in late 1982 of approximately 1.1 percent per transfused unit. The decrease after 1982 coincided with the implementation of high-risk donor deferral measures. It is estimated that, overall, approximately 2135 transfusion recipients were infected with HIV-1 in the San Francisco region alone. This number suggests a higher prevalence of transfusion-associated HIV-1 infection than has been generally recognized and indicates the need for continued tracing of potentially exposed recipients. The data also strongly support the effectiveness of early donor education and self-exclusion measures and emphasize the importance of continued research and development in this area.
authors.affiliation: Irwin Memorial Blood Centers, San Francisco, California.
authors.forename: M P
authors.initials: MP
authors.lastname: Busch
authors.forename: M J
authors.initials: MJ
authors.lastname: Young
authors.forename: S M
authors.initials: SM
authors.lastname: Samson
authors.forename: J W
authors.initials: JW
authors.lastname: Mosley
authors.forename: J W
authors.initials: JW
authors.lastname: Ward
authors.forename: H A
authors.initials: HA
authors.lastname: Perkins
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000635:transmission; D001782:Blood Donors; D001803:Blood Transfusion; D015483:HIV Antibodies / Q000032:analysis*; D015497:HIV-1 / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012495:San Francisco; D013997:Time Factors
chemical_list: D015483:HIV Antibodies