5-Hydroxytryptamine amplifies beta-adrenergic stimulation of N-acetyltransferase activity in rat pinealocytes.
In cultured rat pinealocytes beta-adrenergic induction of N-acetyltransferase, a key enzyme in the synthesis of melatonin, is amplified by addition of 5-hydroxytryptamine (5-HT) to the culture medium. However, 5-HT when added alone has no effect on enzyme activity. Pharmacological experiments with a range of agonists and antagonists suggest that this action is not mediated by 5-HT1, 5-HT2, 5-HT3, or 5-HT4 receptor subtypes but may involve a site similar to the 5-HT1p receptor described in the enteric nervous system. The potential role of 5-HT in modulating adrenergic stimulation of N-acetyltransferase activity is discussed.
Sugden
D
D
Biomedical Sciences Division, King's College London, England.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D004357:Drug Synergism; D007545:Isoproterenol / Q000494:pharmacology*; D010870:Pineal Gland / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D012701:Serotonin; D001191:Arylamine N-Acetyltransferase; D007545:Isoproterenol