Regression estimation from grouped observations applied to structurally diverse D2-receptor antagonists.
Four groups of chemically diverse dopamine D2-receptor antagonists with different group size were studied. The total sample consisted of a mixture of distributions with some influential observations, and the grouped data were characterized by different dispersion matrices but equal mean vectors. Thus, it was difficult to employ pattern recognition approaches. Design repair was used to develop a quantitative structure-activity relationship equation. It was shown that the inhibition constant of all groups depends on the true lipophilic constant.
Mager
P P
PP
Research Group for Pharmacochemistry, Faculty of Medicine, University of Leipzig, GDR.
Rothe
H
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D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011954:Receptors, Dopamine / Q000187:drug effects*; D012044:Regression Analysis
D015259:Dopamine Agents; D011954:Receptors, Dopamine