title: Relation between severity and extent of precancerous lesions in the postoperative stomach.
abstract: The relation between the severity and extent of precancerous lesions in a precancerous condition of the stomach was assessed, to find a means of reducing the endoscopic workload required for the detection of such lesions. 87 subjects who had had gastric surgery for peptic ulcer more than 20 years ago underwent gastric endoscopy and biopsy. Severity of dysplasia correlated with its extent. Severity of intestinal metaplasia correlated with its extent and with severity of dysplasia. Type of operation, but not sex or type of ulcer, was the factor most strongly associated with dysplasia. Previous Billroth II operations were more strongly associated with occurrence of dysplasia (85%) than were other operations. In patients with previous Billroth II operations, moderate and severe dysplasia were commoner around the stoma (37%) than in the body (10%). These findings indicate that there is a relation between the severity and extent of precancerous lesions, which suggests that patients with dysplasia have widespread gastric mucosal instability. They also indicate that, if endoscopic screening is limited to Bilroth II subjects and if biopsies are limited to the stoma, endoscopic workload can be reduced by 85%, with only a small reduction (15%) in detection of moderate and severe dysplasia.
authors.affiliation: Norman Tanner Gastroenterology Unit, St George's Hospital Medical School, London, UK.
authors.forename: R S
authors.initials: RS
authors.lastname: Savalgi
authors.forename: C M
authors.initials: CM
authors.lastname: Corbishley
authors.forename: C
authors.initials: C
authors.lastname: Caygill
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: M G
authors.initials: MG
authors.lastname: Cook
authors.forename: J S
authors.initials: JS
authors.lastname: Kirkham
authors.forename: T C
authors.initials: TC
authors.lastname: Northfield
mesh_terms: D001706:Biopsy; D004386:Duodenum / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005763:Gastroenterostomy; D005773:Gastroscopy; D006801:Humans; D007583:Jejunum / Q000601:surgery; D008297:Male; D010437:Peptic Ulcer / Q000601:surgery*; D011230:Precancerous Conditions / Q000145:classification / Q000473:pathology*; D011708:Pylorus / Q000601:surgery; D012307:Risk Factors; D012737:Sex Factors; D013270:Stomach / Q000601:surgery*; D013274:Stomach Neoplasms / Q000473:pathology*; D013997:Time Factors; D014628:Vagotomy