title: Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues.
abstract: The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctadiene lignan lactones for activity were clarified.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tomioka
authors.forename: T
authors.initials: T
authors.lastname: Ishiguro
authors.forename: H
authors.initials: H
authors.lastname: Mizuguchi
authors.forename: N
authors.initials: N
authors.lastname: Komeshima
authors.forename: K
authors.initials: K
authors.lastname: Koga
authors.forename: S
authors.initials: S
authors.lastname: Tsukagoshi
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
authors.forename: S
authors.initials: S
authors.lastname: Tanida
authors.forename: T
authors.initials: T
authors.lastname: Kishi
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007624:KB Cells; D017705:Lignans; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D017705:Lignans; C002858:steganacin; D015107:4-Butyrolactone