[T- and B-lymphocytes and their clinico-pathogenetic significance in patients with paranoid schizophrenia].
As many as 43 patients with first diagnosed paranoid schizophrenia running a shift-like course were examined for the blood counts of T and B lymphocytes with regard to the treatment conducted and disease standing. The patients received 3 types of the treatment: insulin, neuroleptics and combined treatment (insulin plus neuroleptics). During the treatment and after it, the content of B lymphocytes remained practically unchanged (p greater than 0.05) in all the patients. The content of T lymphocytes was reduced throughout the whole period of affliction with schizophrenia. However, during the combined treatment of the disease, a tendency towards increase of T cells was revealed, which coincided with the best clinical indicators.
Saĭfulina
N A
NA
Arkhipov
G S
GS
Stepanov
A F
AF
Gusev
Iu A
IuA
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008231:Lymphopenia / Q000276:immunology / Q000523:psychology*; D008297:Male; D011379:Prognosis; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D014150:Antipsychotic Agents