A new HaeIII polymorphism at the D21S13 locus.
DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a,b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus.
Pulst
S M
SM
Division of Neurology, Cedars-Sinai Medical Center, University of California, Los Angeles 90048.
Korenberg
J R
JR
Ren
M
M
Greenwald
J
J
D015139:Blotting, Southern; D002891:Chromosomes, Human, Pair 21; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D015252:Deoxyribonucleases, Type II Site-Specific; C024403:GGCC-specific type II deoxyribonucleases