[Indicators of the dexamethasone test in patients with affective disorders after administration of neuro- and psychotropic drugs].
A study was made of the effect of the antidepressants desmethylimipramine, mianserin, befol, alpha-adrenoblockers of pyrroxane, phentolamine as well as tryptophan, clonidine, propranolol, salbutamol, and the benzodiazepine tranquilizer phenazepam on the dexamethasone test (DMT). The drugs possessing antidepressive effect in nonsuppressors improved the parameters of the DMT at the expense of decreasing the postdexamethasone level of cortisol while the serotonin-positive drugs tryptophan and befol did not produce any effect on the predexamethasone level of cortisol whereas mianserin, desmethylimipramine, pyrroxane and phentolamine slightly reduced the predexamethasone level of cortisol, influencing to a greater degree the postdexamethasone level. In suppressors, the serotonin-positive drugs deteriorated the parameters of the test whereas the agents affecting the adrenergic transmission did not change it. Phenazepam materially lowered the level of cortisol in suppressors and nonsuppressors. It is concluded that the antidepressive action is realized via the serotoninergic systems and alpha-adrenoreceptors.
Nuller
Iu L
IuL
Ostroumova
M N
MN
Kosinskiĭ
V P
VP
D000293:Adolescent; D000322:Adrenergic Agonists / Q000008:administration & dosage*; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy / Q000503:physiopathology*; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008875:Middle Aged; D013268:Stimulation, Chemical; D013565:Sympatholytics / Q000008:administration & dosage*
D000322:Adrenergic Agonists; D000928:Antidepressive Agents; D013565:Sympatholytics; D003907:Dexamethasone; D006854:Hydrocortisone