title: Inability to demonstrate physiologic correlates of subjective improvement among patients taught the relaxation response.
abstract: OBJECTIVE
  To assess whether the regular elicitation of the relaxation response produces sustained physiologic changes coincident with symptomatic relief or improved psychological state.
  
  
  METHODS
  Prospective, cohort pilot study.
  
  
  METHODS
  Clinical research center within a teaching hospital.
  
  
  METHODS
  Thirteen athletic men, mean age 44.8 years, with borderline or labile hypertension, taking no medication. All 13 completed the study.
  
  
  METHODS
  Three baseline assessments of psychological state, symptom checklist, and assessment of autonomic response to infusion of beta agonist (isoproterenol). Daily relaxation response exercises for five consecutive weeks followed by repeat assessment of all parameters. Discontinuation of relaxation exercises for subsequent five weeks followed by repeat assessment of all parameters.
  
  
  RESULTS
  After eliciting the relaxation response, subjects demonstrated significant decreases in anxiety (p less than 0.014) and somatic symptoms (p less than 0.02). Psychological and somatic variables returned toward baseline after the subsequent discontinuation of relaxation exercises. No significant concomitant change in urinary catecholamines, heart rate response to isoproterenol, blood pressure, pulse rate, or serum cholesterol was demonstrated.
  
  
  CONCLUSIONS
  The regular elicitation of the relaxation response can improve psychological performance and reduce symptoms. However, the physiologic mechanism whereby these psychological and symptomatic improvements occur remains poorly understood and warrants further investigation.
authors.affiliation: Division of General Medicine, Beth Israel Hospital, Boston, MA 02215.
authors.forename: D M
authors.initials: DM
authors.lastname: Eisenberg
authors.forename: L
authors.initials: L
authors.lastname: Landsberg
authors.forename: E N
authors.initials: EN
authors.lastname: Allred
authors.forename: R B
authors.initials: RB
authors.lastname: Saper
authors.forename: T L
authors.initials: TL
authors.lastname: Delbanco
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000652:urine; D002784:Cholesterol / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000523:psychology*; D007545:Isoproterenol; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012064:Relaxation Therapy
chemical_list: D002395:Catecholamines; D002784:Cholesterol; D007545:Isoproterenol