Activators of ATP-sensitive K+ channels reduce anoxic depolarization in CA3 hippocampal neurons.
In CA3 hippocampal neurons of the rat, brief anoxic episodes produce a depolarization which is probably due to a synaptic release of glutamate. Diazoxide, an activator of ATP-sensitive K+ channels (K+ ATP), blocks the anoxic depolarization and has no effect in control oxygenated artificial cerebrospinal fluid. The hormone somatostatin which activates K+ ATP channels in the pancreas also reduces the anoxic depolarization in CA3 neurons. We suggest that drugs that open K+ ATP channels may constitute a novel approach to selectivity reducing the deleterious effects of excessive release of glutamate during anoxia without producing a generalized blockade of glutamatergic synaptic transmission.
Ben-Ari
Y
Y
INSERM U. 29, Hôpital de Port-Royal, Paris, France.
Krnjević
K
K
Crépel
V
V
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects*; D003981:Diazoxide / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D016318:Quisqualic Acid / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013004:Somatostatin / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
D015221:Potassium Channels; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D013779:Tetrodotoxin; D013004:Somatostatin; D000255:Adenosine Triphosphate; D016318:Quisqualic Acid; D007736:Kynurenic Acid; D003981:Diazoxide