title: The effect of fatty acids on the rectal absorption of acyclovir in rats.
abstract: The enhancing effect of fatty acids on the rectal absorption of acyclovir has been evaluated in rats. Acyclovir proved to be absorbed to the extent of 3 to 9% after oral administration. After rectal administration in the absence of absorption-promoter, the bioavailability of acyclovir was 37%. Its rectal administration with 4% sodium caprate resulted in enhanced bioavailability (81 +/- 3%).
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Sawanoi
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Tanabe
mesh_terms: D000212:Acyclovir / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000285:Administration, Rectal; D000818:Animals; D001682:Biological Availability; D002210:Caprylates / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D007850:Lauric Acids / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002210:Caprylates; D005227:Fatty Acids; D007850:Lauric Acids; C030358:lauric acid; C031492:octanoic acid; D000212:Acyclovir