title: Minimal Rev-response element for type 1 human immunodeficiency virus.
abstract: Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.
authors.affiliation: Department of Pathology, University of California, San Francisco 94143-0506.
authors.forename: X J
authors.initials: XJ
authors.lastname: Huang
authors.forename: T J
authors.initials: TJ
authors.lastname: Hope
authors.forename: B L
authors.initials: BL
authors.lastname: Bond
authors.forename: D
authors.initials: D
authors.lastname: McDonald
authors.forename: K
authors.initials: K
authors.lastname: Grahl
authors.forename: T G
authors.initials: TG
authors.lastname: Parslow
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D015752:Genes, env; D015497:HIV-1 / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000737:chemistry; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D012333:RNA, Messenger