Further evidence for the hypothesis that beta-endorphin mediates maternal deprivation effects.
Lung DNA synthesis was examined in 9-day-old rat pups following a 2-hour separation from their mothers (maternal deprivation), and compared to that of pups placed with a nipple ligated dam (food deprivation) or a lactating dam (control). Maternally deprived pups consistently showed a significant reduction in lung DNA synthesis which was not attributable to food deprivation. Central administration of naloxone prevented the decrease in DNA synthesis observed after maternal deprivation but did not inhibit the reductions in lung DNA synthesis seen two hours after sc administration of isoproterenol, suggesting that DNA response to maternal deprivation is a specific opioid receptor mediated event. These results are consistent with previous reports from our laboratory indicating that CNS beta-endorphin may mediate many of the biological alterations observed following maternal deprivation in neonatal rats.
Greer
N L
NL
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Bartolome
J V
JV
Schanberg
S M
SM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004261:DNA Replication; D004285:Dogs; D005260:Female; D005508:Food Deprivation; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008426:Maternal Deprivation; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013936:Thymidine / Q000378:metabolism; D001615:beta-Endorphin / Q000502:physiology*
D009270:Naloxone; D001615:beta-Endorphin; D007545:Isoproterenol; D013936:Thymidine