title: Immunotherapy for recurrent malignant glioma: an interim report on survival.
abstract: We present interim survival data for a group of 83 adult patients with recurrent malignant glioma treated by implanting stimulated autologous lymphocytes into the tumour bed following surgical debulking. The patients were treated 6 months or more prior to data analysis. Fifty-nine patients were male and 24 female. The mean age for the entire group was 48.4 years and the mean Karnofsky rating (KR) was 67.2. Eight of the patients had grade II tumours, 33 had grade III tumours and 42 had grade IV tumours. Statistical analysis focuses on tumour grade, KR and patient age, factors that have been shown to affect survival in previous studies. Multifactorial analyses are employed to identify interrelationships among factors related to survival. Seven patients (8%) did not respond to immunotherapy, 76 (92%) had a good initial response. Twenty-five patients (30.1%) are living and 18 (22%) have shown no evidence of recurrence. Results are evaluated in the light of those obtained in trials of other experimental therapies for recurrent malignant gliomas. It is concluded that the present protocol offers a safe and comparatively effective treatment option.
authors.affiliation: Experimental and Clinical Immunotherapy Laboratory, Huntington Medical Research Institutes, (HMRI) Pasadena, CA 91101.
authors.forename: M
authors.initials: M
authors.lastname: Ingram
authors.forename: J G
authors.initials: JG
authors.lastname: Buckwalter
authors.forename: D B
authors.initials: DB
authors.lastname: Jacques
authors.forename: D B
authors.initials: DB
authors.lastname: Freshwater
authors.forename: R M
authors.initials: RM
authors.lastname: Abts
authors.forename: G B
authors.initials: GB
authors.lastname: Techy
authors.forename: K
authors.initials: K
authors.lastname: Miyagi
authors.forename: C H
authors.initials: CH
authors.lastname: Shelden
authors.forename: R W
authors.initials: RW
authors.lastname: Rand
authors.forename: L W
authors.initials: LW
authors.lastname: English
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000401:mortality / Q000628:therapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D002140:California / Q000453:epidemiology; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D010835:Phytohemagglutinins / Q000494:pharmacology; D016019:Survival Analysis; D015996:Survival Rate; D013601:T-Lymphocytes / Q000187:drug effects / Q000637:transplantation
chemical_list: D007376:Interleukin-2; D010835:Phytohemagglutinins