title: Comparison of angiographic methods for the assessment of the extent of experimental anterior myocardial infarction in dog hearts.
abstract: Infarction was provoked in the dog by introducing a copper coil into the left anterior descending coronary artery. Eight groups, each of 6 dogs, were studied which received various treatments and were evaluated after 24 hours or 1 week. The anatomical extent of infarction was measured by the triphenyltetrazoliumhydrochloride method; size was evaluated angiographically by the centerline, chord and radial method and by ejection fraction. The extent of infarction was similar in groups studied after 24 hours and 1 week. Angiographical changes were most marked after 24 hours, and the ejection fraction was related to the extent of infarction (r = -0.5; P less than 0.02). Some parameters of the radial and centerline method showed also a relation to the extent of infarction (r = 0.47 to 0.57; P less than 0.05). After one week, the ejection fraction was no longer correlated to the extent of infarction. The correlation between the parameters of the chord, radius and centerline method and the extent of infarction improved to r-values of 0.58 to 0.63 (P less than or equal to 0.01). There was no difference between the 3 methods.
authors.affiliation: Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: I K
authors.initials: IK
authors.lastname: Jang
authors.forename: F
authors.initials: F
authors.lastname: van de Werf
authors.forename: J
authors.initials: J
authors.lastname: Vanhaecke
authors.forename: A
authors.initials: A
authors.lastname: Aubert
authors.forename: H
authors.initials: H
authors.lastname: De Geest
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000792:Angiography / Q000379:methods*; D015901:Angiography, Digital Subtraction / Q000379:methods; D000818:Animals; D002932:Cineangiography / Q000379:methods; D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D004285:Dogs; D004338:Drug Combinations; D008790:Metoprolol / Q000627:therapeutic use; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013318:Stroke Volume; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision; D010959:Tissue Plasminogen Activator; D008790:Metoprolol