Bacterial antigens in synovial biopsy specimens in yersinia triggered reactive arthritis.
Non-viable structures of Yersinia enterocolitica O:3 were shown at the site of inflammation within mononuclear cells in the synovial membrane of eight out of 10 patients with yersinia triggered reactive arthritis. An avidin-biotin-peroxidase complex method, with a rabbit antiserum specific for Y enterocolitica O:3, was used to visualise yersinia structures. All 13 control samples were negative except for one with non-specific mast cell staining. The findings emphasise the significance of foreign material in the initiation of synovitis in reactive arthritis.
Merilahti-Palo
R
R
Department of Medicine, Turku University, Finland.
Söderström
K O
KO
Lahesmaa-Rantala
R
R
Granfors
K
K
Toivanen
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000032:analysis*; D001170:Arthritis, Infectious / Q000276:immunology* / Q000473:pathology; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000276:immunology* / Q000473:pathology; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology*
D000942:Antigens, Bacterial; D015796:HLA-B27 Antigen