Salicylate inhibits human placental sulphate transport in vitro.
The effect of salicylate on sulphate transport by the human placenta has been studied using isolated brush-border membrane vesicles and placental tissue slices. Sulphate uptake by isolated vesicles was inhibited in a dose dependent fashion (K1 approximately 3 mM) by salicylate. It appears that this drug blocks sulphate accumulation in a non-competitive manner. Sulphate efflux from preloaded vesicles was also found to be markedly reduced by salicylate in a non-competitive fashion. Consistent with the vesicle studies salicylate inhibited sulphate transport by placental tissue slices. The results suggest that salicylate ingestion could compromise feto-placental sulphate homeostasis. In addition we have found that the aspirin-like drug, flufenamic acid, inhibits sulphate transport by isolated microvillus membrane vesicles.
Shennan
D B
DB
Hannah Research Institute, Ayr, U.K.
Russell
T V
TV
D001692:Biological Transport / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005439:Flufenamic Acid / Q000494:pharmacology; D006801:Humans; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D012459:Salicylates / Q000494:pharmacology*; D020156:Salicylic Acid; D013431:Sulfates / Q000493:pharmacokinetics*; D013696:Temperature
D012459:Salicylates; D013431:Sulfates; D005439:Flufenamic Acid; D020156:Salicylic Acid