title: Cytogenetic analysis of a granulocytic sarcoma in a patient without systemic leukaemia.
abstract: Granulocytic sarcoma is a rare complication of leukaemia. Occasionally it presents before the development of systemic leukaemia when diagnosis may be difficult. A case of granulocytic sarcoma occurring in a patient with no overt evidence of leukaemia, but in whom cytogenetic analysis of the bone marrow showed a clonal t(12;13) translocation, is reported. Cytogenetic analysis of tissues in this disease may indicate evidence of systemic disease before overt morphological changes.
authors.affiliation: Department of Human Genetics, University of Newcastle upon Tyne.
authors.forename: L R
authors.initials: LR
authors.lastname: Adam
authors.forename: B
authors.initials: B
authors.lastname: Angus
authors.forename: P
authors.initials: P
authors.lastname: Carey
authors.forename: E V
authors.initials: EV
authors.lastname: Davison
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic