Antenatal intervention for congenital cystic adenomatoid malformation.
In 2 fetuses with congenital cystic adenomatoid malformation (CCAM) with hydrops, in-utero resection of the enlarged pulmonary lobe reduced mediastinal shift and allowed expansion of normal lung tissue in both cases. In case 1, the 27-week-gestation fetus died from severe hydrops after premature delivery. In case 2, fetal CCAM resection was completed at 23 weeks' gestation. At 30 weeks a girl was delivered with no evidence of pulmonary hypoplasia. Fetal surgery can now be entertained for otherwise fatal space-occupying intrathoracic lesions.
Harrison
M R
MR
Fetal Treatment Program, University of California, San Francisco 94143-0570.
Adzick
N S
NS
Jennings
R W
RW
Duncan
B W
BW
Rosen
M A
MA
Filly
R A
RA
Goldberg
J D
JD
deLorimier
A A
AA
Golbus
M S
MS
D000328:Adult; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000175:diagnosis / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000601:surgery*; D005323:Fetal Monitoring; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000150:complications; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011379:Prognosis; D016216:Ultrasonography, Prenatal