Pyrimidobenzodiazepines. Synthesis of pirenzepine analog.
The synthesis of Pyrimido[4,5-b][1,5]benzodiazepine derivatives from 4-(o-aminophenylene)amino-5-ethoxy-carbonyl-1,2-dihydro-6-methyl-2 - oxopyrimidine has been described. Pyrimidobenzodiazepine 5 alkylated with N-methyl-N'-chloroacetyl-piperazine gives a product related to pirenzepine. Compound 5 shows weak antianxiety and antidepressive action.
Długosz
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A
Department of Organic Chemistry, Medical University, Faculty of Pharmacy, Wrocław, Poland.
Machoń
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis*; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001570:Benzodiazepinones; D011743:Pyrimidines; D001569:Benzodiazepines; C066346:2-hydroxy-4-methylpyrimido(4,5-b)(1,5)benzodiazepin-5-one; D010890:Pirenzepine