title: A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.
abstract: X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern--transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation.
authors.affiliation: Department of Genetics, Stanford University School of Medicine, California 94305.
authors.forename: C J
authors.initials: CJ
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
authors.forename: J L
authors.initials: JL
authors.lastname: Rupert
authors.forename: R G
authors.initials: RG
authors.lastname: Lafreniere
authors.forename: M
authors.initials: M
authors.lastname: Grompe
authors.forename: R
authors.initials: R
authors.lastname: Tonlorenzi
authors.forename: H F
authors.initials: HF
authors.lastname: Willard
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D004303:Dosage Compensation, Genetic; D015870:Gene Expression; D006801:Humans; D007621:Karyotyping; D008969:Molecular Sequence Data; D014158:Transcription, Genetic; D014960:X Chromosome