title: Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan: muscle biopsy findings in 4 patients.
abstract: Muscle biopsies of 4 patients with the eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan showed lymphocytic infiltrates with occasional eosinophils largely restricted to interstitial fibrous tissue and perivascular areas. There was inflammation and fibrosis of muscle spindle capsules in 3 patients. In the 2 sickest patients, there was profound muscle atrophy, affecting both muscle fiber types.
authors.affiliation: Department of Neurology, Tufts University School of Medicine, Boston, MA.
authors.forename: D
authors.initials: D
authors.lastname: Hollander
authors.forename: L S
authors.initials: LS
authors.lastname: Adelman
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001706:Biopsy; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D009220:Myositis / Q000139:chemically induced / Q000473:pathology; D010146:Pain; D013577:Syndrome; D014364:Tryptophan / Q000009:adverse effects*
chemical_list: D014364:Tryptophan