[Immunological status of patients with recurrent herpes simplex infections. In vitro effect of thymopoietin and splenin-derived and partially modified peptides on peripheral blood lymphocytes in comparison to a thymus extract].
Immunological studies on 20 patients with frequently recurrent Herpes simplex labialis were performed. Disorders of the cell-mediated immunity were often observed which do not only occur during the relapses. The number of T cells and their function were especially reduced. On the other hand there were no alterations of the CD4/CD8 ratio and the suppressor-activity. In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections.
Simon
H U
HU
Institut für Klinische Immunologie, Friedrich-Schiller-Universität, Jena.
Roth
H
H
Forner
K
K
Haroske
D
D
D000595:Amino Acid Sequence; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens; D002908:Chronic Disease; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010446:Peptide Fragments; D013946:Thymopoietins; D013949:Thymus Extracts; D013951:Thymus Hormones; C041898:splenopentin; C032841:thymopoietin III; D016305:Thymopentin