Hepatitis B core antigen specific CD4 response in peripheral blood.
The proliferative response of peripheral blood CD4+ T cells to recombinant hepatitis B core antigen (rHBcAg) has been studied in patients with chronic active hepatitis (CAH) type B (CAH-B), CAH-nonA nonB, and normal volunteers. CD4+ T cells from patients with CAH-B indicated a significant proliferative response to rHBcAg in the presence of non-T antigen presenting cells. In contrast, there was no apparent T cell reaction to rHBcAg in patients with CAH-nonA nonB and healthy volunteers. We suggested the possibility of CD4-mediated HBcAg specific response even in the peripheral blood compartments of HBcAg-responsive CAH-B patients.
Shirai
M
M
Third Department of Internal Medicine, Kagawa Medical School, Japan.
Watanabe
S
S
Nishioka
M
M
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004926:Escherichia coli / Q000235:genetics; D006509:Hepatitis B / Q000276:immunology*; D006512:Hepatitis B Core Antigens / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D006521:Hepatitis, Chronic / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010957:Plasmids; D011994:Recombinant Proteins
D006512:Hepatitis B Core Antigens; D011994:Recombinant Proteins