Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporine A-treated, immunosuppressed rats.
In adult rats infected with Borna disease virus, the virus was found exclusively in the brain, whereas in cyclosporine A-treated rats, infectious virus was also detected in peripheral nerve fibers and, unexpectedly, in adjacent organ-specific cells. In contrast to untreated virus-infected rats, no major histocompatibility complex class II expression was found in the brain of cyclosporine A-treated animals.
Stitz
L
L
Institut für Virologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
Schilken
D
D
Frese
K
K
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001890:Borna Disease / Q000276:immunology* / Q000473:pathology; D001891:Borna disease virus / Q000302:isolation & purification*; D001921:Brain / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000382:microbiology; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007165:Immunosuppression Therapy; D008099:Liver / Q000382:microbiology / Q000473:pathology; D009928:Organ Specificity; D051381:Rats; D011917:Rats, Inbred Lew
D000956:Antigens, Viral; D003524:Cyclosporins; D000949:Histocompatibility Antigens Class II