c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13).
Molecular and cytogenetic analyses were performed on chronic B-lymphocytic cell leukemia (CLL) from a 57-year-old male patient with del(12)(p13) anomaly. The deletion did not remove the K-ras-2 gene. However, c-myc gene amplification correlated with high-level expression, suggesting the involvement of this gene in the induction of neoplasia in this patient.
Wang
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Department of Molecular Oncology, Alton Ochsner Medical Foundation, New Orleans, LA 70121.
Samples
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Dabdoub
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Prakash
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D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged