Iscom (immunostimulating complex) vaccines containing mono- or polyvalent pili of enterotoxigenic E. coli; immune response of rabbit and swine.
Iscom (immunostimulating complex) vaccines were prepared to contain K88ab, K88ac, K99 and 987P pili (fimbriae) of enterotoxigenic E. coli bacteria as monovalent or quadrivalent preparations. The iscoms injected into rabbits and into pigs elicited similar or higher immune response in both animal species than the oil adjuvanted vaccine containing about 5 times more of the same pilus protein. It is concluded that inclusion of pili into iscoms results in immunogenic preparations likely worth pursuing for vaccine production against enterotoxic colibacillosis of newborn pigs. The iscoms did not induce local reaction at the injection sites in contrast to the oil adjuvanted vaccines.
Nagy
B
B
Central Veterinary Institute, Budapest, Hungary.
Höglund
S
S
Morein
B
B
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D010861:Fimbriae, Bacterial / Q000276:immunology; D011817:Rabbits / Q000276:immunology*; D013552:Swine / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines