Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola.
Kolaviron, a mixture of C-3/C-8 linked biflavonoids obtained from Garcinia kola produces significant hypoglycaemic effects when administered intraperitoneally to normal and alloxan diabetic rabbits at a dose of 100 mg kg-1. The fasting blood sugar in normoglycaemic rabbits was reduced from 115 mg/100 mL to 65 mg/100 mL after 4 h. In alloxan diabetic rabbits, the blood sugar was lowered from 506 mg/100 mL to 285 mg/100 mL at 12 h. The hypoglycaemic effects have been compared with those of tolbutamide. Kolaviron inhibited rat lens aldose reductase (RLAR) activity, with an IC50 value of 5.4 x 10(-6). The significance of these findings in the potential use of kolaviron as an antidiabetic agent is discussed.
Iwu
M M
MM
Phytotherapy Research Laboratory, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Igboko
O A
OA
Okunji
C O
CO
Tempesta
M S
MS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005419:Flavonoids / Q000494:pharmacology*; D007004:Hypoglycemic Agents; D010946:Plants, Medicinal / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D005419:Flavonoids; D007004:Hypoglycemic Agents; D014044:Tolbutamide; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; C045492:kolaviron