Glucose utilization by interscapular brown adipose tissue in vivo during nutritional transitions in the rat.
Glucose utilization indices (GUI) of interscapular brown adipose tissue (IBAT) declined by 84% after 48 h starvation. Two-thirds of the overall response was observed within 6 h, correlating with decreased insulin concentrations. Re-feeding 48 h-starved rats restored insulin concentrations and evoked a rapid 15-fold increase in IBAT GUI. GUI values after re-feeding were markedly higher than those observed at equivalent insulin concentrations in control post-absorptive rats.
Holness
M J
MJ
Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, U.K.
Liu
Y L
YL
Beech
J S
JS
Sugden
M C
MC
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D004435:Eating; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*
D007328:Insulin; D005947:Glucose