title: The relative dependence of calcium antagonists and neuroleptics binding to brain and heart receptors on drug lipophilicity.
abstract: QSAR analysis of the binding of calcium antagonists to brain and heart tissue shows that relative binding to brain tissue increases with increasing octanol/water partition coefficients. A number of antischizophrenic drugs follow the same pattern.
authors.affiliation: Department of Chemistry, Pomona College, Claremont, CA 91711.
authors.forename: W
authors.initials: W
authors.lastname: Rojratanakiat
authors.forename: C
authors.initials: C
authors.lastname: Hansch
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
chemical_list: D014150:Antipsychotic Agents; D002121:Calcium Channel Blockers