Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms.
We analyzed the possibility of inherited predisposition to nondisjunction in a family with two cases of Down syndrome using restriction fragment length polymorphisms and cytogenetic heteromorphisms. In both patients the extra chromosome 21 was the result of a nondisjunction event at first meiotic division in the mother. Since both patients are maternally related, genetic predisposition cannot be excluded in this family.
Stinissen
P
P
Department of Biochemistry, University of Antwerp, Belgium.
Van Roy
B
B
Van Camp
G
G
Backhovens
H
H
Partoens
P
P
Wehnert
A
A
Verniers
H
H
Dumon
J
J
Vandenberghe
A
A
Van Broeckhoven
C
C
D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008126:Lod Score; D008297:Male; D008540:Meiosis; D009630:Nondisjunction, Genetic; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D004247:DNA