[Rheologic effects of salmon calcitonin on post-menopausal osteoporosis. Results of a preliminary study].
The aim of this random blind vs placebo study was to assess the effect of salmon calcitonin (sCT) (100 UI/day intermuscular for 4 weeks) on the haemorheological pattern of 20 women, all non-smokers, aged between 50 and 65 years of age and affected by post-menopausal osteoporosis. Hematocrit, whole blood viscosity at high and low shear rates, plasma viscosity, red blood cell aggregation, dynamic deformation and viscosity were monitored. Our results show sCT ex vivo seems to act upon mechanisms regulating the plastic properties of the red blood cell membrane.
Ciuffetti
G
G
Instituto di Clinica Medica II, Università degli Studi di Perugia, Policlinico Monteluce.
Ciacca
A
A
Lombardini
R
R
Scarponi
A M
AM
Paltriccia
R
R
Orecchini
G
G
D002116:Calcitonin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D012212:Rheology
C028815:salmon calcitonin; D002116:Calcitonin