Gastrin pathophysiology: antisecretory drugs.
The management of maintenance therapy in peptic disease (oesophagus, stomach, duodenum) with antisecretory drugs should keep in consideration the aspect of developing hypergastrinemia: gastrin exerts a throphic effect on gastric ECL and parietal cells. After a long term maintenance therapy (3-5) years) with ranitidine 150mg/die in a group of 55 patients affected by duodenal ulcer, 20% of them developed hypergastrinemia and gastric hypersecretion (evaluated after one week of drug withdrawal). The same 20% of the subjects showed increased relapse rates with respect to those who did develop the same gastrin/gastric acid increase.
Delle Fave
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Cattedra di Gastroenterologia 1, Università La Sapienza, Roma, Italy.
Annibale
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B
De Magistris
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L
D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans
D005755:Gastrins; D006635:Histamine H2 Antagonists