title: The influence of endogenous hypocorticism on the replication of influenza virus in the mouse lungs and the production of specific antibodies.
abstract: The replication of pathogenic influenza virus A/PR/8/34 in the lungs and the synthesis of virus-neutralizing (VN) and haemagglutination-inhibition (HI) antibodies has been studied in mice with endogenous hypocorticism induced by a bilateral adrenalectomy. The adrenalectomized mice appeared to be more susceptible to influenza infection as compared to the mock-operated ones. This was evident from earlier deaths and higher death rate in mice inoculated with 50 EID50, 1000 EID50, and 6000 EID50 of the virus, respectively. A tendency towards decrease of specific antibody titres and the resistance to reinfection with influenza virus A/PR/8/34 was also observed.
authors.affiliation: Moscow Research Institute of Viral Preparations, U.S.S.R. Ministry of Health.
authors.forename: V F
authors.initials: VF
authors.lastname: Semenkov
authors.forename: L V
authors.initials: LV
authors.lastname: Levina
authors.forename: V F
authors.initials: VF
authors.lastname: Lavrov
authors.forename: O N
authors.initials: ON
authors.lastname: Ageeva
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications*; D000315:Adrenalectomy; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002455:Cell Division; D002642:Chick Embryo; D004198:Disease Susceptibility; D006385:Hemagglutination Inhibition Tests; D009980:Influenza A virus / Q000276:immunology / Q000502:physiology*; D008168:Lung / Q000382:microbiology*; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D013154:Spleen / Q000166:cytology; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral