Hypersensitivity pneumonitis versus invasive pulmonary aspergillosis: two cases with unusual pathologic findings and review of the literature.
Two brothers simultaneously exposed to moldy hay, who developed differing forms of Aspergillus-related lung disease, are presented. Patient 1 developed a true case of hypersensitivity lung disease, whereas his brother developed invasive aspergillosis with bronchoalveolar lavage eosinophilia and unusual pathologic features including tissue eosinophilia. The possible overlap between hypersensitivity pneumonitis and invasive aspergillosis in the immunocompetent host is discussed.
Meeker
D P
DP
Department of Pulmonary Disease, Cleveland Clinic Foundation, OH 44195-5038.
Gephardt
G N
GN
Cordasco
E M
EM
Wiedemann
H P
HP
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000000981:diagnostic imaging / Q000209:etiology*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology / Q000473:pathology; D004802:Eosinophilia / Q000150:complications; D006099:Granuloma / Q000150:complications / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D013902:Radiography, Thoracic
D000935:Antifungal Agents