Intrathecal somatostatin produces effects dependent on the interval between catheter implantation and drug injection.
Intrathecal (i.t.) injection of somatostatin has been reported to depress nociceptive reflexes as well as to cause severe disturbance of somatomotor performance. The present study was designed to assess the dependence of these effects on the dose and the interval between implantation of the catheter and i.t. injection of somatostatin in rats. The effects produced by i.t. injection of somatostatin consisted of an increase in the response latencies of nociceptive responses to noxious heat, impairment of motor performance and grooming behavior, convulsions, and death. Except for grooming behavior, these were related in incidence and degree to the dose and the interval, the potency of somatostatin being highest at short intervals. Sham operations also affected the effectiveness of somatostatin.
Dirksen
R
R
University of Nijmegen, Institute for Anesthesiology, The Netherlands.
Lerou
J
J
Nijhuis
G M
GM
Booij
L H
LH
Jurna
I
I
D000818:Animals; D002404:Catheterization; D004305:Dose-Response Relationship, Drug; D006120:Grooming / Q000187:drug effects; D007278:Injections, Spinal; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010146:Pain; D010147:Pain Measurement; D051381:Rats; D011919:Rats, Inbred Strains; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012640:Seizures / Q000139:chemically induced; D012890:Sleep / Q000187:drug effects; D013004:Somatostatin / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D013004:Somatostatin