Differential recovery of dopamine synthetic enzymes following MPTP and the consequences of GM1 ganglioside treatment.
After 7 days of treatment with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), 30 mg/kg i.p., tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) activities are decreased by more than 50% in the mouse striatum. Within 30 days, AAAD activity returns while TH activity remains depressed. TH activity can be restored to near normal by chronic treatment with GM1 ganglioside, 30 mg/kg i.p.
Hadjiconstantinou
M
M
Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210.
Neff
N H
NH
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives*; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001522:Behavior, Animal / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D004298:Dopamine / Q000096:biosynthesis*; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D005677:G(M1) Ganglioside; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine