The histological maturity of regenerating mucosa of healed duodenal ulcer and ulcer recurrence after treatment with H2-antagonist.
We investigated the relationship between the histological maturity of regenerating mucosa of healed duodenal ulcer and ulcer recurrence, after treatment with an H2-antagonist. Duodenal ulcer patients were given H2-antagonists (either cimetidine or famotidine) for 4 wk of therapy. Fifty-two (77.6%) of the 67 patients were healed endoscopically. The histological state of the regenerating mucosa of healed duodenal ulcer was divided into three categories: good, fair, and poor patterns. Of the 52 healed patients, 15 achieved a good histological pattern. None of these 15 patients had a recurrence 3 months later. However, nine of the 37 patients with a fair or poor pattern of regenerating mucosa had a recurrence 3 months after healing (p = 0.034). We concluded that a duodenal ulcer should be treated until the regenerating mucosa of the healed ulcer reaches a good histological pattern, so as to prevent the recurrence of the ulcer.
Pan
S
S
Department of Internal Medicine, Taipei Medical College, Taiwan, R.O.C.
Liao
C H
CH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D004384:Duodenoscopy; D015738:Famotidine / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006635:Histamine H2 Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012038:Regeneration / Q000187:drug effects*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine