title: Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in the chronically instrumented dog.
abstract: Seven mongrel dogs were chronically instrumented for the measurement of aortic and left ventricular blood pressures, cardiac output, left ventricular wall thickening, left ventricular dP/dt, and circumflex coronary, renal, hepatic and portal blood flows under the influence of desflurane (D) and isoflurane (I). Administration of the two anesthetics, was randomized, as was the order of the concentrations administered. Each dog was studied awake and at 1.2, 1.4, 1.75, and 2.0 MAC of each anesthetic on different days. Both anesthetics decreased mean arterial pressure, stroke volume, systemic vascular resistance, left ventricular dP/dt, and wall thickness. The decreases were dose-dependent for mean arterial pressure (percent of awake values: D 78, I 85 at 1.2 MAC, and D 67, I 69 at 2.0 MAC); stroke volume (D 66, I 72 at 1.2 MAC, and D 52, I 57 at 2.0 MAC); dP/dt (D 61, I 64 at 1.2 MAC, and D 46, I 49 at 2.0 MAC); and WT (D 68, I 70 at 1.2 MAC, and D 47, I 60 at 2.0 MAC). Systemic vascular resistance decreased approximately the same at 1.2 MAC (D 71, I 87%) as at 2.0 MAC (D 71, I 79%). Heart rate increased but also not in a dose-dependent fashion (percent of awake values: D 177, I 145 at 1.2 MAC, and D 176, I 155 at 2.0 MAC). Coronary blood flow was increased by both anesthetics at all concentrations (percent of awake values: I 136 at 1.2 MAC and 161 at 2.0 MAC of awake, and D 131 at 1.2 MAC and 138 at 2.0 MAC.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, University of Texas Health Science Center, Houston 77030.
authors.forename: R G
authors.initials: RG
authors.lastname: Merin
authors.forename: J M
authors.initials: JM
authors.lastname: Bernard
authors.forename: M F
authors.initials: MF
authors.lastname: Doursout
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: J E
authors.initials: JE
authors.lastname: Chelly
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D000077335:Desflurane; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008102:Liver Circulation / Q000187:drug effects*; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D000077335:Desflurane; D007530:Isoflurane