title: Expression of intercellular adhesion molecule-1 (ICAM-1) on renal-cell cancer: possible significance in host immune responses.
abstract: In this study we examined the expression of intercellular adhesion molecule-1 (ICAM-1) in 28 cases of renal-cell cancer (RCC). We also examined ICAM-1 expression on RCC cell lines in response to cytokines. Immunohistochemistry revealed frequent expression (23 positive cases among the 28 RCCs) of ICAM-1 in RCC. The molecule was not detected on renal tubular cells as far as could be determined. Furthermore, the number of ICAM-1-positive cells in RCC was significantly correlated with the degree of mononuclear cell infiltration, involving mainly T lymphocytes and a smaller number of macrophages bearing the LFA-1 molecule. Expression of ICAM-1 on RCC cell lines was augmented by in vitro treatment with interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1)beta. These results suggest that the expression of ICAM-1 on RCC might be modified by cytokines produced by tumor-infiltrating mononuclear cells, and that ICAM-1 expression on RCC might augment the host immune reaction.
authors.affiliation: Department of Immunology, Niigata University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Fujiwara
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis*; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D002465:Cell Movement / Q000276:immunology; D016207:Cytokines / Q000494:pharmacology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1; D007680:Kidney Neoplasms / Q000276:immunology* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1