title: Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats.
abstract: Ornithine decarboxylase (ODC) and thymidine kinase (TK) are enzymes important for DNA synthesis, a process that is critical for cell renewal and regeneration. As such, they already have been used as surrogate markers of regeneration in tissue. In the present study, the activity of these two enzymes in plasma of rats and regenerating hepatic tissue following a 70% hepatectomy were determined. The results demonstrate that the changes in these enzyme activities in plasma reflect the changes obtained in the liver tissue. Thus, blood levels of ODC and TK can be used as a less invasive and nondestructive means of monitoring the regenerative response of the liver and possibly other tissues.
authors.affiliation: Department of Gastroenterology, University of Bari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Polimeno
authors.forename: A
authors.initials: A
authors.lastname: Azzarone
authors.forename: P
authors.initials: P
authors.lastname: Dell'Aquila
authors.forename: C
authors.initials: C
authors.lastname: Amoruso
authors.forename: M
authors.initials: M
authors.lastname: Barone
authors.forename: A
authors.initials: A
authors.lastname: Angelini
authors.forename: D H
authors.initials: DH
authors.lastname: Van Thiel
authors.forename: A
authors.initials: A
authors.lastname: Francavilla
mesh_terms: D000818:Animals; D003600:Cytosol / Q000201:enzymology; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology; D008115:Liver Regeneration / Q000502:physiology*; D009955:Ornithine Decarboxylase / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000097:blood / Q000378:metabolism*
chemical_list: D013937:Thymidine Kinase; D009955:Ornithine Decarboxylase