Incidence of hairy cell leukemia, mycosis fungoides, and chronic lymphocytic leukemia in first known HTLV-II-endemic population.
Unlike human T cell leukemia-lymphoma virus type I (HTLV-I), HTLV-II has not been convincingly linked to a malignancy. In the first 10 months of serologic screening for HTLV-I/II among blood donors in New Mexico in 1988-1989, HTLV-I/II infection was found in 27 donors. HTLV-I/II infection was present in 1.0%-1.6% of American Indian and 0.16%-0.27% of Hispanic donors compared with 0.009%-0.06% of non-Hispanic white donors. HTLV-II was identified by DNA amplification in 12 of 13 samples from Indian and Hispanic seropositive donors. Despite apparent endemic HTLV-II infection in these populations, New Mexico Tumor Registry data showed that the incidences of hairy cell leukemia, mycosis fungoides, and chronic lymphocytic leukemia were comparable among the three ethnic groups. A population with endemic HTLV-II infection has been identified, and there is no evidence of increased risk for these three malignancies in the endemic groups.
Hjelle
B
B
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.
Mills
R
R
Swenson
S
S
Mertz
G
G
Key
C
C
Allen
S
S
D001782:Blood Donors; D015491:HTLV-II Infections / Q000150:complications / Q000453:epidemiology*; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D007198:Indians, North American; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000453:epidemiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000453:epidemiology*; D008403:Mass Screening; D009182:Mycosis Fungoides / Q000150:complications / Q000453:epidemiology*; D009516:New Mexico / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D016036:Seroepidemiologic Studies; D012878:Skin Neoplasms / Q000150:complications / Q000453:epidemiology*; D044465:White People