Accumulation and metabolism of 2,4,6-trichlorophenyl-4'-aminophenyl ether by carp.
1. Accumulation of 2,4,6-trichlorophenyl-4'-aminophenyl ether (CNP-amino) in carp was investigated for 14 days. CNP-amino in carp could be divided into free CNP-amino [CNP-amino(I)] and bound CNP-amino [CNP-amino(II)]. 2. The bioconcentration factors (BCF) of CNP-amino(I + II) in carp were 90 +/- 38 (mean +/- SD, n = 3) for muscle, 402 for liver, 501 for kidney and 5368 for gallbladder after 14 days exposure. 3. 2,4,6-Trichlorophenyl-4'-acetamide phenyl ether (CNP-acetamide) was detected as metabolites of CNP-amino in muscle and viscera of carp.
Tsuda
T
T
Shiga Prefectural Institute of Public Health and Environmental Science, Japan.
Aoki
S
S
Kojima
M
M
Harada
H
H
D000818:Animals; D002347:Carps / Q000378:metabolism*; D005704:Gallbladder / Q000378:metabolism; D006540:Herbicides / Q000378:metabolism / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D013058:Mass Spectrometry; D009132:Muscles / Q000378:metabolism; D010647:Phenyl Ethers / Q000378:metabolism / Q000493:pharmacokinetics*
D006540:Herbicides; D010647:Phenyl Ethers; C067259:2,4,6-trichlorophenyl-4'-aminophenyl ether