Inflammatory status and preerythrocytic stages of malaria: role of the C-reactive protein.
In the acquisition of protection against malaria, the role played by nonspecific factors, some being part of the cascade effect of cytokines, has to be considered. The C-reactive protein, a major acute phase reactant secreted by interleukin-1 stimulated hepatocytes, has an effect on the hepatic development of Plasmodia, both by preventing penetration of the sporozoite into the hepatocyte and by blocking parasite division through an antibody-like effect. This latter effect confirms the potential interest of targeting the uninuclear form of the parasite. Nevertheless, C-reactive Protein alone does not account for all the effects of the inflammatory response, other reactants from both serum and hepatocytes are also involved.
Nussler
A
A
Institut National de la Santé et de la Recherche Médicale U 313, Groupe, Hospitalier Pitié Salpétrière, Paris, France.
Pied
S
S
Pontet
M
M
Miltgen
F
F
Renia
L
L
Gentilini
M
M
Mazier
D
D
D000818:Animals; D002097:C-Reactive Protein / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007249:Inflammation; D008099:Liver / Q000276:immunology / Q000469:parasitology*; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D010967:Plasmodium yoelii / Q000254:growth & development / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D002097:C-Reactive Protein