title: The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.
abstract: The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation in vitro of MH1C1 cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (approximately 50%) was observed at two separate dose ranges: one at 10(-7)-10(-10) M, and one at 10(-14)-10(-15) M.
authors.affiliation: Department of Clinical Pharmacology, Rikshospitalet, Oslo, Norway.
authors.forename: J E
authors.initials: JE
authors.lastname: Paulsen
authors.forename: K
authors.initials: K
authors.lastname: Sundby-Hall
authors.forename: L
authors.initials: L
authors.lastname: Endresen
authors.forename: H E
authors.initials: HE
authors.lastname: Rugstad
authors.forename: K L
authors.initials: KL
authors.lastname: Reichelt
authors.forename: K
authors.initials: K
authors.lastname: Elgjo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000737:chemistry / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D009842:Oligopeptides; D010455:Peptides; C067151:pyroglutamyl-glutaminyl-glycyl-seryl-asparagine; D004247:DNA; D011761:Pyrrolidonecarboxylic Acid