Regulation of forearm lipolysis in different types of obesity. In vivo evidence for adipocyte heterogeneity.
Forearm and systemic adipose tissue free fatty acid (FFA) release was measured in eight nonobese, six lower-body obese, and eight upper-body obese women under basal, hyperinsulinemic, and hypoinsulinemic conditions to determine whether forearm fat is regulated in a similar manner as whole body fat.


RESULTS
Adipose tissue palmitate release was greater from forearm than whole body (5.97 +/- 0.75 vs. 3.84 +/- 0.34 mumol.kg fat-1.min-1, respectively, P less than 0.005, n = 22 subjects). Systemic palmitate release, relative to fat mass, was significantly (P less than 0.01) greater in nonobese than upper-body obese, and upper-body obese than lower-body obese women, and forearm adipose tissue palmitate release followed the same pattern. Hyperinsulinemia suppressed systemic and forearm lipolysis to similar degrees, however, hypoinsulinemia consistently increased systemic palmitate flux without increasing forearm palmitate release. These results confirm the heterogeneity of adipose tissue in an in vivo model and emphasize the need to consider which adipose tissue depots are responsible for the differences in systemic FFA flux in obese and nonobese humans.
Jensen
M D
MD
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005542:Forearm; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008066:Lipolysis; D009765:Obesity / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000493:pharmacokinetics
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D010169:Palmitic Acids; D019308:Palmitic Acid; D005934:Glucagon