[Acute nephrotoxicity by CDDP (on tubular damage)].
Cisplatin (CDDP) is known to cause a nephrotoxic side effect. By using urinary trehalase which is localized renal tubular brush border, we examined an acute cisplatin nephrotoxicity. 1) With less than 300 mg of CDDP, urinary trehalase activity in the 1st day was significantly increased than preadministration. And urinary beta 2-MG was significantly increased in the 2nd day. But urinary NAG was not significantly increased. 2) With 300 mg or more of CDDP, urinary trehalase, beta 2-MG and NAG were more increased than preadministration. Urinary trehalase and beta 2-MG were inclined to increment. But urinary NAG was not inclined to decrement. Above all, renal tubular damage is reversible with less than 300 mg of CDDP, but is irreversible with 300 mg or more of CDDP.
Higuchi
K
K
Department of Obstetrics and Gynecology, Aichi Medical University, Japan.
Negoro
Y
Y
Suzuki
M
M
Noguchi
M
M
Nakanishi
M
M
Ishihara
M
M
Nakano
M
M
D000118:Acetylglucosaminidase / Q000652:urine; D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004796:Clinical Enzyme Tests / Q000379:methods; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects* / Q000201:enzymology; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D014198:Trehalase / Q000652:urine; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D014198:Trehalase; D000118:Acetylglucosaminidase; D002945:Cisplatin