title: Atypical differentiation of bronchiolar epithelial cells following experimental pneumonia.
abstract: In the bronchiolar and alveolar epithelial responses to experimentally induced organizing pneumonia in the rat evoked by Streptococcus pneumoniae type 25, the appearance of lamellar body-containing bronchiolar cells is reported. Such cells, which are interspersed among proliferating type 2 pneumocytes in the form of intraalveolar and bronchiolar buds, also stain immunohistochemically with antisera to alveolyn, a surfactant-associated protein. We believe this phenomenon supports an hypothesis that in response to specific stimuli, proliferation of a common precursor cell of both the bronchiolar Clara cell and the type 2 pneumocyte occurs, with varying expression of a latent or precursor capacity for surfactant secretion.
authors.affiliation: School of Pathology, University of New South Wales, Kensington, Australia.
authors.forename: G C
authors.initials: GC
authors.lastname: Rhodes
authors.forename: R K
authors.initials: RK
authors.lastname: Kumar
authors.forename: A W
authors.initials: AW
authors.lastname: Lykke
authors.forename: J W
authors.initials: JW
authors.lastname: Tapsall
mesh_terms: D000818:Animals; D001980:Bronchi / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D004848:Epithelium / Q000473:pathology; D005260:Female; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D011008:Pneumococcal Infections; D011014:Pneumonia / Q000382:microbiology / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains