title: Thyroxine-binding prealbumin gene polymorphism: a population study.
abstract: The human thyroxine-binding prealbumin (TBPA) gene was examined for restriction fragment length polymorphism (RFLP) in normal subjects and a subject with euthyroid hyperthyroxinaemia, due to increased thyroxine binding by TBPA, using 16 restriction enzymes. Only Taq I and Msp I were shown to detect RFLPs. In a male of the normal population and one of his daughters, an additional Taq I site was found in the 3'-flanking region of the TBPA gene. The RFLP in a subject with euthyroid hyperthyroxinaemia was due to the deletion of a MspI site. All three subjects with RFLPs were heterozygous.
authors.affiliation: Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.
authors.forename: M T
authors.initials: MT
authors.lastname: Akbari
authors.forename: N J
authors.initials: NJ
authors.lastname: Fitch
authors.forename: M
authors.initials: M
authors.lastname: Farmer
authors.forename: K
authors.initials: K
authors.lastname: Docherty
authors.forename: M C
authors.initials: MC
authors.lastname: Sheppard
authors.forename: D B
authors.initials: DB
authors.lastname: Ramsden
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D003201:Computers; D004587:Electrophoresis, Agar Gel; D005091:Exons / Q000235:genetics; D005260:Female; D005796:Genes / Q000235:genetics; D006801:Humans; D006981:Hyperthyroxinemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011228:Prealbumin / Q000235:genetics*; D013975:Thyroxine-Binding Proteins / Q000235:genetics*
chemical_list: D011228:Prealbumin; D013975:Thyroxine-Binding Proteins