Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs.
Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg, d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls.
Allard
P
P
Department of Psychiatry, University of Umeå, Sweden.
Eriksson
K
K
Ross
S B
SB
Marcusson
J O
JO
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010879:Piperazines / Q000378:metabolism*; D020891:Raclopride; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D012457:Salicylamides / Q000494:pharmacology
D015259:Dopamine Agents; D010879:Piperazines; D011954:Receptors, Dopamine; D012457:Salicylamides; D001971:Bromocriptine; D020891:Raclopride; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D003042:Cocaine; D006220:Haloperidol; D003913:Dextroamphetamine