Stability of somatostatin in total parenteral nutrition.
The stability of somatostatin, added to a total parenteral nutrition formula, in glass containers and in plastic ethylene vinyl acetate containers was investigated. The somatostatin concentration decreased immediately from 3 micrograms/ml to 0.3-0.6 micrograms/ml after addition to the emulsion. In spite of this rapid decrease, somatostatin concentrations remained stable with values of 0.4-0.7 micrograms/ml during the follow-up period (24 h). These findings could be explained assuming adsorption to the surface of the container.
Montoro
J B
JB
Hospital Pharmacy Service, Hospital General Vall d'Hebron, Barcelona, Spain.
Galard
R
R
Catalan
R
R
Martinez
J
J
Salvador
P
P
Sabin
P
P
D004349:Drug Packaging; D004355:Drug Stability; D004655:Emulsions; D005898:Glass; D007457:Iodine Radioisotopes; D010289:Parenteral Nutrition, Total; D011863:Radioimmunoassay; D013004:Somatostatin / Q000008:administration & dosage / Q000737:chemistry*; D014753:Vinyl Compounds
D004655:Emulsions; D007457:Iodine Radioisotopes; D014753:Vinyl Compounds; D013004:Somatostatin; C011566:vinyl acetate