Adenyl cyclase activity in human alveolar macrophages.
The inflammatory mediators PGE2, DC-PGI2 and histamine as well as the beta-adrenergic drugs isoprenaline and salbutamol increase intracellular cyclic AMP-concentrations whereas Platelet Activating Factor does not induce any change in adenyl cyclase activity of normal human alveolar macrophages. Functional H2-histaminergic and beta 2-adrenergic receptor-subtypes are coupled to macrophage adenyl cyclase.
Beusenberg
F D
FD
Department of Pharmacology, Erasmus University Rotterdam, The Netherlands.
van Amsterdam
J G
JG
van Schaik
J M
JM
Hoogsteden
H C
HC
Bonta
I L
IL
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D011453:Prostaglandins; D006632:Histamine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases