title: Characteristics of 86Rb+ transport in human erythrocytes infected with Plasmodium falciparum.
abstract: Human red cells infected in vitro with Plasmodium falciparum showed a significant increase in the rate of both ouabain-sensitive and ouabain-insensitive 86Rb+ influx. The increase in ouabain-insensitive 86Rb+ influx was due, in part, to increased transport via a bumetanide-sensitive system and, in part to transport via a pathway that was absent (or at least inactive) in uninfected cells. The parasite-induced pathway was inhibited by piperine and had a dose response very similar to that of the Gardos channel of uninfected cells but was less sensitive than the Gardos channel to inhibition by quinine.
authors.affiliation: University Laboratory of Physiology, Oxford, U.K.
authors.forename: K
authors.initials: K
authors.lastname: Kirk
authors.forename: K J
authors.initials: KJ
authors.lastname: Ashworth
authors.forename: B C
authors.initials: BC
authors.lastname: Elford
authors.forename: R A
authors.initials: RA
authors.lastname: Pinches
authors.forename: J C
authors.initials: JC
authors.lastname: Ellory
mesh_terms: D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D001692:Biological Transport; D002034:Bumetanide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011188:Potassium / Q000378:metabolism; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology; D012414:Rubidium Radioisotopes
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D012414:Rubidium Radioisotopes; D002034:Bumetanide; D010042:Ouabain; D011803:Quinine; D011188:Potassium; C008922:piperine