title: Responses to cimaterol in genetically obese and lean pigs.
abstract: Twenty-four genetically obese and 24 lean barrows were allotted within genotype to either a 16% CP corn-soybean meal basal diet, the basal + .69 ppm cimaterol or the basal + 1.38 ppm cimaterol. Pigs had ad libitum access to their diets from 59.3 kg to 104.5 kg body weight. No genotype x cimaterol interactions were detected (P greater than .05). Neither genotype nor cimaterol supplementation had any effect (P greater than .05) on average daily weight gain or gain-to-feed ratio. Compared with lean pigs, obese pigs had higher fasting plasma urea nitrogen (BUN), a smaller gastrointestinal tract and a greater dressing percentage with a shorter and fatter carcass (P less than .05). Cimaterol produced a higher fasting plasma BUN, a greater dressing percentage with a leaner carcass and a higher shear force value for loin chops (P less than .05). Cimaterol also tended (P less than .10) to increase heart weight. However, no difference was observed in these measurements between pigs fed .69 or 1.38 ppm cimaterol. In lean pigs fed the basal or .69 ppm cimaterol diet, there was no difference (P greater than .05) in the 8 to 24 h postprandial whole-animal heat production. Cimaterol effectively decreased fat deposition and increased lean accretion both in genetically obese and in lean pigs; there were no differential responses to cimaterol in pigs with different propensities to deposit body fat.
authors.affiliation: ARS, Roman L. Hruska U.S. Meat Anim. Res. Center, U.S. Department of Agriculture, Clay Center, NE 68933.
authors.forename: J T
authors.initials: JT
authors.lastname: Yen
authors.forename: H J
authors.initials: HJ
authors.lastname: Mersmann
authors.forename: J A
authors.initials: JA
authors.lastname: Nienaber
authors.forename: D A
authors.initials: DA
authors.lastname: Hill
authors.forename: W G
authors.initials: WG
authors.lastname: Pond
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000254:growth & development; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001806:Blood Urea Nitrogen; D004435:Eating / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D005838:Genotype; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000187:drug effects*; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000235:genetics* / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; C047411:cimaterol