title: New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia.
abstract: The karyotype 47,XX, + 8,t(12;22)(p13;q12) was found at diagnosis in two patients with acute nonlymphocytic leukemia (ANLL). The bone marrow morphology of both patients corresponded to the M4 subtype of the French-American-British (FAB) classification. The translocation t(12;22) has not previously been reported as the sole structural aberration in ANLL.
authors.affiliation: Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: Y J
authors.initials: YJ
authors.lastname: Hull
authors.forename: I R
authors.initials: IR
authors.lastname: Toogood
authors.forename: T
authors.initials: T
authors.lastname: Fioretos
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000328:Adult; D002648:Child; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014314:Trisomy