title: Dietary taurine deficiency and dilated cardiomyopathy in the fox.
abstract: Taurine deficiency has been implicated as a potential cause of dilated cardiomyopathy. However, the relationship between taurine and myocardial function is presently unclear. The purpose of this study was to determine whether dilated cardiomyopathy in the fox is associated with dietary taurine deficiency. A total of 68 foxes from farms with a history of death caused by dilated cardiomyopathy and 14 foxes from a farm with no history of dilated cardiomyopathy were studied. Dilated cardiomyopathy was diagnosed by echocardiography in 48% of the foxes from one farm with a positive history and in none of the foxes from the control farm. Foxes less than 9 months of age were more commonly affected than older foxes (p = 0.03). Plasma taurine concentrations were significantly less (p less than 0.01) in foxes that had dilated cardiomyopathy (26.8 +/- 16.4 nmol/ml) than in the control foxes (99.3 +/- 60.2 nmol/ml). A significantly higher (p less than 0.01) incidence of dilated cardiomyopathy was present in foxes with a history of a sibling or offspring that died of dilated cardiomyopathy than in foxes without a family history of cardiac death. In one fox with dilated cardiomyopathy that was tested, the myocardial taurine concentration was lower (1.7 mumol/gm wet weight) than that of control foxes (7.3 +/- 1.6 mumol/gm wet weight). Hepatic cysteinesulfinic acid decarboxylase activity was significantly less (p less than 0.001) in foxes with dilated cardiomyopathy (0.97 +/- 0.2 nmol/mm.mg protein) than in control foxes (2.11 +/- 0.07 nmol CO2/mm.mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca.
authors.forename: N S
authors.initials: NS
authors.lastname: Moise
authors.forename: L M
authors.initials: LM
authors.lastname: Pacioretty
authors.forename: F A
authors.initials: FA
authors.lastname: Kallfelz
authors.forename: M H
authors.initials: MH
authors.lastname: Stipanuk
authors.forename: J M
authors.initials: JM
authors.lastname: King
authors.forename: R F
authors.initials: RF
authors.lastname: Gilmour
mesh_terms: D000818:Animals; D002262:Carboxy-Lyases / Q000032:analysis; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D004452:Echocardiography; D005260:Female; D005589:Foxes / Q000502:physiology*; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000473:pathology; D013654:Taurine / Q000097:blood / Q000172:deficiency*
chemical_list: D013654:Taurine; D002262:Carboxy-Lyases; C019972:sulfoalanine decarboxylase