title: The pivotal role of the Leu-CAM and ICAM molecules in human leukocyte adhesion.
abstract: Cellular adhesion is of fundamental importance in leukocyte physiology. It is a complex, strictly regulated process, which involves the participation of several cell surface glycoproteins. Among the most important are the Leu-CAMs or the CD11/CD18 integrin receptors, and their adhesion ligands ICAM-1 (CD54) and ICAM-2. In this review we summarize some recent work on various aspects of these molecules.
authors.affiliation: Department of Biochemistry, University of Helsinki, Finland.
authors.forename: C G
authors.initials: CG
authors.lastname: Gahmberg
authors.forename: P
authors.initials: P
authors.lastname: Nortamo
authors.forename: C
authors.initials: C
authors.lastname: Kantor
authors.forename: M
authors.initials: M
authors.lastname: Autero
authors.forename: P
authors.initials: P
authors.lastname: Kotovuori
authors.forename: L
authors.initials: L
authors.lastname: Hemiö
authors.forename: R
authors.initials: R
authors.lastname: Salcedo
authors.forename: M
authors.initials: M
authors.lastname: Patarroyo
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D018845:CD11 Antigens; D018821:CD18 Antigens; D002413:Cations, Divalent / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism; D007239:Infections / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1; D007962:Leukocytes / Q000502:physiology*; D010703:Phorbol Esters / Q000494:pharmacology; D016028:Receptors, Leukocyte-Adhesion / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D018845:CD11 Antigens; D018821:CD18 Antigens; D002413:Cations, Divalent; D015815:Cell Adhesion Molecules; C065289:ICAM2 protein, human; D010703:Phorbol Esters; D016028:Receptors, Leukocyte-Adhesion; D011993:Recombinant Fusion Proteins; D018799:Intercellular Adhesion Molecule-1