"Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia.
We report a case of acute monocytic leukemia (FAB-5a) with a very aggressive clinical course and multiple chromosomal abnormalities. There were several sublines, each with trisomy 8 and a translocation involving 3q13.3 as a common breakpoint region. This region is an uncommon site of chromosomal breakage in malignancies and has not hitherto been reported as a breakpoint site in "jumping" translocations.
Reis
M D
MD
Department of Laboratory Hematology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Dubé
I D
ID
Pinkerton
P H
PH
Chen-Lai
J
J
Robinson
J B
JB
Klock
R J
RJ
Senn
J S
JS
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy
D015703:Antigens, CD