Bronchopulmonary dysplasia: improvement in lung function between 7 and 10 years of age.
To evaluate the natural history of bronchopulmonary dysplasia, we studied the same 32 patients at a mean age of 7 and 10 years. The group as a whole had normal height and weight percentiles, and each child grew along his or her established somatic growth curve. Although some children had abnormal values, the group maintained a normal mean total lung capacity and functional residual capacity. The mean residual volume and the residual volume/total lung capacity ratios were elevated at both ages. At age 7 years the 19 patients (59%) who had a forced expiratory volume in 1 second (FEV1) of less than 80% had "catch up" improvement by 10 years of age (65 +/- 11% to 72 +/- 16% of predicted value; p less than 0.05). All the children who had a normal FEV1 at 7 years of age continued to have a normal FEV1 at age 10 years. Resting single-breath carbon monoxide uptake by the lung was normal when measured at age 10 years. The majority of patients had a positive methacholine challenge test result at both ages, although there was a low incidence of clinically diagnosed asthma. This study demonstrates that patients with bronchopulmonary dysplasia who have normal lung function at age 7 have had normal lung growth and that those with evidence of mild to moderate lung disease have continued lung growth or repair, or both, during their school years.
Blayney
M
M
Neonatology, Division, Hospital for Sick Children, Toronto, Ontario, Canada.
Kerem
E
E
Whyte
H
H
O'Brodovich
H
H
D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002248:Carbon Monoxide / Q000378:metabolism*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005540:Forced Expiratory Flow Rates / Q000502:physiology; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000254:growth & development / Q000503:physiopathology; D008297:Male; D011379:Prognosis; D015656:Respiratory Mechanics; D014109:Total Lung Capacity / Q000502:physiology
D002248:Carbon Monoxide