Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells.
The effects of flavonoids on L-[14C]tyrosine uptake into cultured adrenal chromaffin cells were examined. Flavone markedly stimulated tyrosine uptake into these cells in a manner dependent on its concentration. Apigenin also caused a moderate stimulatory action, but quercetin had no significant effect on the uptake. Flavone also stimulated the uptake of histidine, but did not affect the uptake of serine, lysine, or glutamic acid. These results are considered to propose the possibility that flavonoids may be able to stimulate the precursor uptake into the cells, resulting in an enhancement of the biogenic amine production.
Morita
K
K
Department of Pharmacology, Tokushima University School of Medicine, Japan.
Hamano
S
S
Oka
M
M
Teraoka
K
K
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002250:Carbon Radioisotopes; D002395:Catecholamines / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D020843:Chamomile; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006639:Histidine / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D009822:Oils, Volatile / Q000494:pharmacology; D010946:Plants, Medicinal; D011794:Quercetin / Q000494:pharmacology; D012694:Serine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D002250:Carbon Radioisotopes; D002395:Catecholamines; D047309:Flavones; D005419:Flavonoids; D005971:Glutamates; D009822:Oils, Volatile; D018698:Glutamic Acid; D014443:Tyrosine; D012694:Serine; D006639:Histidine; D011794:Quercetin; D008239:Lysine; C043562:flavone