Effect of naproxen sodium on the net synthesis of glycosaminoglycans and protein by normal canine articular cartilage in-vitro.
The effects of the non-steroidal anti-inflammatory drug, naproxen sodium, on the metabolism of normal canine articular cartilage has been examined. At a concentration approaching that achieved in synovial fluid of patients treated with the drug (i.e. 30 micrograms mL-1) naproxen sodium had no significant effect on net synthesis of either glycosaminoglycans or protein in organ cultures of femoral condylar cartilage, nor did it increase the proportion of newly synthesized glycosaminoglycans recovered from the culture medium, suggesting that it had no direct effect on the integrity of the extracellular matrix.
Brandt
K D
KD
Indiana University School of Medicine, Indianapolis 46202-5103.
Albrecht
M
M
D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D046508:Culture Techniques; D004285:Dogs; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D007930:Leucine / Q000378:metabolism; D009288:Naproxen / Q000494:pharmacology*; D014176:Protein Biosynthesis; D013462:Sulfur Radioisotopes
D006025:Glycosaminoglycans; D013462:Sulfur Radioisotopes; D009288:Naproxen; D007930:Leucine