Anti-inflammatory properties of a preparation containing low doses of copper, gold and silver.
The efficacy of a drug containing three heavy metals together has been tested in adjuvant-induced arthritic rats. Treated rats were injected with 22.8 micrograms copper gluconate, 0.2 microgram gold thioglucose and 6.8 micrograms silver proteinate each day during a period of 29 days. The drug treatment was found to diminish the increases in plasma levels of haptoglobin, ceruloplasmin, PGE2, 6-keto-PGF1 alpha and copper, the decrease in the iron plasma level induced by Freund's adjuvant and the paw swelling. No effect was seen on the plasma levels of TXB2, Zn, Se, Mn and Ni. Therefore the simultaneous administration of low doses of gold, copper and silver had a real anti-rheumatic property in this model. These results should be of interest for the long-term treatment of arthritis.
Moiny
G
G
Laboratoire de Radiobiologie et de Biochimie, Université de Liège, Belgium.
Thunus
L
L
Dauphin
J F
JF
Deby-Dupont
G
G
Deby
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018501:Antirheumatic Agents / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001798:Blood Proteins / Q000032:analysis; D003300:Copper / Q000494:pharmacology*; D004338:Drug Combinations; D004487:Edema / Q000473:pathology; D005528:Foot / Q000473:pathology; D006046:Gold / Q000494:pharmacology*; D008297:Male; D008670:Metals / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D011453:Prostaglandins / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D001798:Blood Proteins; D004338:Drug Combinations; D008670:Metals; D011453:Prostaglandins; D012834:Silver; D006046:Gold; D003300:Copper