[The effect of a peptide-containing extract of the right hemispheric cortex on the recovery of conditioned reflex activity and on the level of neuromediators in the brain structures of rats after a unilateral frontal lobectomy].
Experiments were conducted on 97 non-inbred [correction of unbred] male rats to study the effect of a peptide-containing extract of the cortex of the right hemisphere of donor rats, who underwent left lobectomy 9 days before the experiment, on restoration of conditioned reflexes of bilateral avoidance and level of neuromediators in the brain structures of recipient rats with a similar damage to the cerebral cortex. It is shown that the brain extract from the right hemisphere of operated on donors has a much higher effect on the restoration of reflexes. At the same time it was found that in left frontal lobectomy this extract produces a most manifest effect on monoamine metabolism in the structures of the right intact hemisphere. It is suggested that a directed effect may possibly be produced on the development of compensatory-restorative process in the central nervous system by endogenous substances of peptide origin which are isolated from brain structures actively contributing to the restoration of disturbed functions.
Romanova
G A
GA
Sovetov
A N
AN
Lutsenko
V K
VK
Ter-Minasian
M K
MK
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology* / Q000601:surgery; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism*; D011612:Psychosurgery; D051381:Rats
D009479:Neuropeptides; D018377:Neurotransmitter Agents