title: Comparative studies of volume restoration following cold-stress induced swelling in renal tissues--I. Effects of ouabain, K+ free medium, colchicine and cytochalasin B on rat and rabbit kidney cortex slices.
abstract: 1. Cold-stress-induced swelling in rabbit and rat kidney cortex slices cannot be due to the sole inhibition of a Na+/K+ exchange system. In these tissues indeed, ouabain induces no swelling and an exchange of Na+ for K+ or a l/l basis. Inhibition of K+ extrusion at low temperature has also to be taken into consideration. 2. Volume restoration at 27 degrees C after cold-stress-induced swelling is inhibited by ouabain in rabbit slices, not in rat ones. The inhibition in rabbit slices is concomitant with an increase in Na+ at levels higher than equilibrium with the external medium. 3. Volume restoration does not seem to implicate colchicine or cytochalasin B sensitive processes.
authors.affiliation: Laboratory of animal physiology, University of Liège, Belgique.
authors.forename: A
authors.initials: A
authors.lastname: Ouahbi
authors.forename: C
authors.initials: C
authors.lastname: Duchêne
authors.forename: R
authors.initials: R
authors.lastname: Gilles
mesh_terms: D000818:Animals; D002712:Chlorides / Q000378:metabolism; D003078:Colchicine / Q000494:pharmacology*; D003080:Cold Temperature; D003571:Cytochalasin B / Q000494:pharmacology*; D003599:Cytoskeleton / Q000502:physiology; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013312:Stress, Physiological; D014867:Water / Q000378:metabolism
chemical_list: D002712:Chlorides; D014867:Water; D003571:Cytochalasin B; D010042:Ouabain; D012964:Sodium; D011188:Potassium; D003078:Colchicine