The role of neurotransmitters in bronchial asthma.
Neural control of airway caliber is far from simple and it is likely to contribute to the airway narrowing in asthma and chronic obstructive airway disease (COAD). Complex interactions may occur between the different components of autonomic control and inflammatory mediators released from cells in the inflamed airway may profoundly alter the balance of neural control. Further elucidation of these interactions should shed light on the mechanisms of airway disease and may lead to therapeutic advances.
Barnes
P J
PJ
Department of Thoracic Medicine, National Heart and Lung Institute, Bromptom Hospital, London, United Kingdom.
D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D009130:Muscle, Smooth / Q000294:innervation; D009479:Neuropeptides / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology
D009479:Neuropeptides; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic