title: Stability of cefazolin sodium in peritoneal dialysis solutions.
abstract: The stability of cefazolin sodium was studied in two commonly used peritoneal dialysis solutions. Cefazolin (as the sodium salt) 250 mg was added to 500-mL bags of dialysis solution containing 1.5% or 4.25% dextrose injection to yield a target concentration of 0.5 mg/mL. Of 18 bags containing 1.5% dextrose injection, six were stored at 4 degrees C, six at 25 degrees C, and six at 37 degrees C. Similarly, of 18 bags containing 4.25% dextrose injection, groups of six were stored at each temperature. Samples were measured for cefazolin concentration by high-performance liquid chromatography at 0, 3, 7, 10, and 14 days for solutions stored at 4 degrees C; 0, 1, 2, 3, 8, and 11 days for solutions stored at 25 degrees C; and 0, 6, 12, and 24 hours for solutions stored at 37 degrees C. The cefazolin concentration in both solutions was greater than or equal to 90% of the initial concentration for 14 days at 4 degrees C, 8 days at 25 degrees C, and 1 day at 37 degrees C. On day 11 at 25 degrees C, however, the loss of cefazolin was 11% for the solution containing 1.5% dextrose injection and 15% for the 4.25% dextrose injection. The sterility of the solutions was not determined. Cefazolin sodium was stable in peritoneal dialysis solutions containing 1.5% and 4.24% dextrose injection for 14 days at 4 degrees C, 8 days at 25 degrees C, and 24 hours at 37 degrees C.
authors.affiliation: College of Pharmacy, Ohio State University, Columbus 43210.
authors.forename: M C
authors.initials: MC
authors.lastname: Nahata
authors.forename: P A
authors.initials: PA
authors.lastname: Ahalt
mesh_terms: D002437:Cefazolin / Q000737:chemistry*; D015314:Dialysis Solutions / Q000737:chemistry*; D004355:Drug Stability; D005947:Glucose / Q000737:chemistry; D013696:Temperature
chemical_list: D015314:Dialysis Solutions; D002437:Cefazolin; D005947:Glucose