title: Prolonged venous infusion of cisplatin and concurrent radiation therapy for lung carcinoma. A feasibility study.
abstract: Fifty patients with non resectable and/or inoperable bronchogenic carcinoma were entered into a feasibility study of cisplatin (CDDP) given in continuous infusion with concurrent radiation therapy. The radiation therapy regimen consisted of 2 Gy given 5 days a week in the first 3 and last 2 weeks of a 7-week split course (50 Gy of total dose). The CDDP (daily dose of 4 to 6 mg/m2) was administered to cover the days of radiation treatment by means of a central venous catheter and a portable pump. Less than 1% of predicted duration of infusion was lost due to complications related to venous access and pump. Toxicity was moderate. The overall probability of a locoregional major response (complete + partial) within 1 month after treatment completion was 86%. Twenty-three patients underwent resection. The 1-year actuarial probability of survival was 64%. The high response and survival rates warrant further studies on concurrent CDDP continuous infusion and radiation therapy in inoperable lung carcinoma.
authors.affiliation: Department of Thoracic Surgical Oncology, National Cancer Institute, Milan, Italy.
authors.forename: A V
authors.initials: AV
authors.lastname: Bedini
authors.forename: L
authors.initials: L
authors.lastname: Tavecchio
authors.forename: F
authors.initials: F
authors.lastname: Milani
authors.forename: A
authors.initials: A
authors.lastname: Gramaglia
authors.forename: C
authors.initials: C
authors.lastname: Spreafico
authors.forename: A
authors.initials: A
authors.lastname: Marchianò
authors.forename: G
authors.initials: G
authors.lastname: Ravasi
mesh_terms: D000328:Adult; D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D015996:Survival Rate
chemical_list: D002945:Cisplatin