Biotransformation of 4-androstene-3,17-dione by green cell suspension of Marchantia polymorpha: stereoselective reduction at carbon 17.
The biotransformation of 4-androstene-3,17-dione by a green cell suspension of Marchantia polymorpha was studied. It was found that the cultured cells stereoselectively reduce the carbonyl group of 4-androstene-3,17-dione from the re-face at C-17 to form testosterone as the primary metabolite.
Hamada
H
H
Department of Applied Science, Okayama University of Science, Japan.
Kawabe
S
S
D000735:Androstenedione / Q000378:metabolism*; D001711:Biotransformation; D002478:Cells, Cultured; D007700:Kinetics; D015394:Molecular Structure; D010944:Plants / Q000378:metabolism*; D013739:Testosterone / Q000302:isolation & purification
D013739:Testosterone; D000735:Androstenedione