title: 8;21 translocation with duplication of the der(21) in a patient with myelomonocytic leukemia.
abstract: An 8;21 translocation with duplication of the der(21) is described in a 72-year-old man who presented with features of chronic myelomonocytic leukemia. Progression to acute myelomonocytic leukemia occurred within one month of diagnosis. The possible prognostic significance of the t(8;21) with duplicated der(21) in myelodysplasia is discussed.
authors.affiliation: Department of Haematology, Western General Hospital, Edinburgh.
authors.forename: M J
authors.initials: MJ
authors.lastname: Auger
authors.forename: F M
authors.initials: FM
authors.lastname: Ross
authors.forename: M J
authors.initials: MJ
authors.lastname: Mackie
mesh_terms: D000368:Aged; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D005810:Multigene Family; D014178:Translocation, Genetic