title: [Regional deep hyperthermia of sarcoma for improving local tumor control].
abstract: 48 patients with advanced sarcomas were treated with regional hyperthermia (RHT) and systemic chemotherapy (ifosfamide/VP-16). 92% of the patients had been pretreated before entering the study. Pretreatment consisted of chemotherapy (33/48), surgery (9/48) or surgery plus irradiation (2/48). Following the conventional treatment, the patients had either relapsed (30/48) or had shown progressive disease (14/48) at the primary site with or without metastases. In 43 patients the overall response rate [5 complete responders (CR) and 6 partial responders (PR)] was 26%, 17 patients revealed no change (NC) and 15 patients showed local tumor progression (PD). A significant correlation of tumor response (responders [CR + PR] versus non-responders [PD]) with intratumoral averaged temperatures could be observed.
authors.affiliation: Klinikum Grosshadern, Medizinische Klinik III, München.
authors.forename: R
authors.initials: R
authors.lastname: Issels
mesh_terms: D000008:Abdominal Neoplasms / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation; D003131:Combined Modality Therapy; D004867:Equipment Design; D005121:Extremities; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D010386:Pelvic Neoplasms / Q000628:therapy; D010865:Pilot Projects; D012509:Sarcoma / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000628:therapy*; D013899:Thoracic Neoplasms / Q000628:therapy