The importance of nucleus accumbens in nicotine-induced locomotor activity.
Bilateral injections of either nicotine (200 micrograms) or cytisine (30 or 60 micrograms) into the nucleus accumbens elicited locomotor hyperactivity in rats. Pretreatment with mecamylamine (2 mg kg-1, s.c.) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that nicotinic agonists such as nicotine and cytisine produce their locomotor excitatory effects through stimulation of the mesolimbic dopaminergic pathway.
Fung
Y K
YK
University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln 68583-0740.
D000470:Alkaloids / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001392:Azocines; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects*; D011292:Premedication; D011807:Quinolizines; D051381:Rats; D011919:Rats, Inbred Strains; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001392:Azocines; D008464:Mecamylamine; D009538:Nicotine; D011807:Quinolizines; C004712:cytisine; D000093843:Quinolizidine Alkaloids