title: Mutagenicity of 3-nitrodibenzofuran and 3-aminodibenzofuran.
abstract: Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzo[a]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and was 10 times stronger in TA98 and about 5 times stronger in TA100 than that of benzo[a]pyrene.
authors.affiliation: Chemistry and Physics Division, National Institute for Environmental Studies, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Uno
authors.forename: H
authors.initials: H
authors.lastname: Matsushita
authors.forename: T
authors.initials: T
authors.lastname: Uehiro
authors.forename: A
authors.initials: A
authors.lastname: Yasuhara
authors.forename: M
authors.initials: M
authors.lastname: Morita
mesh_terms: D001572:Benzofurans / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D001572:Benzofurans; D009153:Mutagens; C067510:3-aminodibenzofuran; C067509:3-nitrodibenzofuran; C023614:dibenzofuran