In vivo effects of di-n-butyltin dichloride on some enzymes and lipids of rat liver plasma membrane.
The in vivo effects of di-n-butyltin dichloride (DBT) on the enzyme activity and lipid constituents of liver plasma membrane were studied in male Albino rats. The rats were intraperitoneally administered with 0.1 ml (10% v/v) ethanol either alone or containing DBT (10 or 30 mg/kg/d) for 7 consecutive days. A significant inhibition of plasma membrane marker enzymes such as 5'-nucleotidase, gamma-glutamyltranspeptidase, alkaline phosphatase, Mg2(+)-ATPase, Na+/K(+)-ATPase and Ca2(+)-ATPase occurred in DBT-treated rats when compared with respective controls. Other important bioconstituents such as sialic acid and total phospholipid/cholesterol ratio were also significantly decreased in DBT-treated rats when compared with corresponding controls. These results suggest that interaction of DBT with liver plasma membrane constituents might cause derangement of its structural and functional organization, thus leading to hepatotoxicity.
Srivastava
S C
SC
Industrial Toxicology Research Centre, Lucknow, India.
D015720:5'-Nucleotidase / Q000037:antagonists & inhibitors; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors
D009947:Organotin Compounds; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase; D000251:Adenosine Triphosphatases; C020735:dibutyldichlorotin