title: Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants.
abstract: The effects of a vegetable-oil-based formula containing 30% 18:2n-6 (18:2 omega-6), 0.8% 18:3n-3, and no n-6 or n-3 long-chain polyunsaturated fatty acids (LCPs) on retina total lipid, ethanolamine phosphoglyceride (EPG), and phosphatidylcholine (PC) fatty acid composition were studied in neonatal piglets. Term-gestation piglets were fed sow milk (SMF) or the formula (FF) from birth for 5, 10, 15, or 25 d. After 25 d feeding, the 22:6n-3 was reduced by 24% in total lipid, 20% in EPG, and 28% in PC of retinas of FF relative to SMF piglets. A compensatory increase in 22:4n-6 and 22:5n-6 concentrations occurred in retina total lipid, EPG, and PC of FF animals. The data suggest that the exclusive feeding of formulas devoid of LCPs and high in 18:2n-6 and/or 18:2n-6 and 18:3n-3 compromises normal accretion of 22:6n-3 in neonatal piglet retina. The potential reversibility of these changes or their effects on vision are not known.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Hrboticky
authors.forename: M J
authors.initials: MJ
authors.lastname: MacKinnon
authors.forename: S M
authors.initials: SM
authors.lastname: Innis
mesh_terms: D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D005227:Fatty Acids / Q000378:metabolism*; D005526:Food, Formulated; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D012160:Retina / Q000378:metabolism*; D013552:Swine
chemical_list: D005227:Fatty Acids; D008041:Linoleic Acids; D010713:Phosphatidylcholines; D010938:Plant Oils; D019787:Linoleic Acid