title: Bone marrow necrosis in leukemic-phase follicular lymphoma.
abstract: Bone marrow necrosis has been regarded as a rare entity in specimens obtained from living patients and has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders, severe infections, and sickle cell anemia. We present an unusual case of a small-cleaved type follicular lymphoma associated with bone marrow necrosis and a leukemic phase occurring in a 55-year-old woman. Specimens were studied by morphologic, immunohistochemical, cytogenetic, and DNA hybridization techniques.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
authors.forename: K
authors.initials: K
authors.lastname: Mehta
authors.forename: B R
authors.initials: BR
authors.lastname: Pawel
authors.forename: C
authors.initials: C
authors.lastname: Gadol
mesh_terms: D001855:Bone Marrow Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D007938:Leukemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D009336:Necrosis; D009693:Nucleic Acid Hybridization
chemical_list: D004273:DNA, Neoplasm