Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes.
Rich
D H
DH
School of Pharmacy, University of Wisconsin-Madison 53706.
Sun
C Q
CQ
Vara Prasad
J V
JV
Pathiasseril
A
A
Toth
M V
MV
Marshall
G R
GR
Clare
M
M
Mueller
R A
RA
Houseman
K
K
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism; D004983:Ethanolamines / Q000737:chemistry* / Q000378:metabolism; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004151:Dipeptides; D004983:Ethanolamines; D017320:HIV Protease Inhibitors; D016333:HIV Protease