title: Adriamycin-induced neoplastic lesions in the Egyptian toad Bufo regularis.
abstract: Injecting adult toads (Bufo regularis) subcutaneously in the dorsal lymph sac with adriamycin at a dose of 2 mg/kg body weight, once every 3 weeks for 20 weeks, induced hepatocellular carcinomas in 20 out of 100 animals. Metastases of the primary liver tumors appeared in the kidneys of 7 toads.
authors.affiliation: Department of Zoology, Faculty of Science, University of Alexandria, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: el-Mofty
authors.forename: V V
authors.initials: VV
authors.lastname: Khudoley
authors.forename: S A
authors.initials: SA
authors.lastname: Sakr
authors.forename: S I
authors.initials: SI
authors.lastname: Osman
authors.forename: B A
authors.initials: BA
authors.lastname: Toulan
mesh_terms: D000818:Animals; D002025:Bufonidae; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D008297:Male
chemical_list: D004317:Doxorubicin