The effect of chronic captopril administration on hepatic blood flow of the rat.
The effect of chronic captopril administration on indocyanine green (ICG) clearance and hepatic extraction has been studied in the rat using the intact liver for ICG clearance and the isolated perfused liver for ICG extraction. The captopril was added to the drinking water to give a calculated daily intake from 0-45 mg kg-1. Hepatic clearance of ICG was dose related from 16.5 +/- 2.4 (control) to 7.2 +/- 1.6 mL min-1 kg-1, respectively. The hepatic extraction of ICG was not significantly different (37 +/- 6%) from the control value in groups on 4 and 45 mg kg-1 daily. Since ICG clearance and extraction are dependent on hepatic blood, a change in ICG clearance without a change in the extraction reflects a similar change in the hepatic blood flow. This remained unchanged at daily captopril intakes of 1 and 4 mg kg-1 and decreased when the daily intake was 10 mg kg-1 or higher. If these results in the rat are applicable to man, the chronic administration of therapeutic doses of captopril (0.5-2 mg kg-1) will not affect the hepatic blood flow.
Bar-Meir
S
S
Department of Gastroenterology, Edith Wolfson Hospital, Holon, Israel.
Prigojin
H
H
Bruck
R
R
Krepel
Z
Z
Avni
Y
Y
D000818:Animals; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007208:Indocyanine Green; D008102:Liver Circulation / Q000187:drug effects*; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains
D002216:Captopril; D007208:Indocyanine Green