Reciprocal translocation involving 3q21 in an unusual myeloproliferative disorder with myelodysplastic features and prominent dysmegakaryopoiesis.
A case with an atypical myeloproliferative disorder (MPD) characterized by overt dysmyelopoiesis, mostly represented by abnormal thrombopoiesis and showing a t(3;18)(q21;q21), is described. The unusual hematological findings, which characterized a disease borderline between two distinct entities, namely MPD and myelodysplastic syndromes, are also discussed in relation to the cytogenetic abnormality affecting region 3q21 and possibly dictating the abnormal thrombopoiesis.
Cedrone
M
M
Department of Human Biopathology, University of Rome La Sapienza, Italy.
Mecucci
C
C
Burgio
V L
VL
Diverio
D
D
Petti
M C
MC
Alimena
G
G
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007621:Karyotyping; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic