Inhibition of cell proliferation by the cholecystokinin antagonist L-364,718.
Specific cholecystokinin (CCK) receptor and gastrin receptor antagonists were used to assess what role, if any, these receptors have in autocrine cell growth. Although the cholecystokinin receptor antagonist, L-364,718, inhibited cell proliferation in a broad spectrum of cell lines, the gastrin antagonist, L-365,260, had no effect on cell proliferation. In addition neither added gastrin17, nor sulfated cholecystokinin8, could reverse the inhibitory action of L-364,718. It is proposed that L-364,718 inhibits cell proliferation independently of classical gastrin/CCK receptors.
Thumwood
C M
CM
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Australia.
Hong
J
J
Baldwin
G S
GS
D001570:Benzodiazepinones / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D003106:Colon / Q000166:cytology / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D020109:Devazepide; D006801:Humans; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; D002766:Cholecystokinin; D020109:Devazepide