The effects of somatostatin and somatostatin antiserum on the retention of passive avoidance behavior after neofrontal decortication in rats.
Rats were tested for passive avoidance behavior in a one-trial step-through learning paradigm. After the learning trial, the animals underwent neofrontal decortication or sham operation. On the 8th day after operation, the lesioned or sham-operated rats received intracerebroventricular (ICV) injections of somatostatin (SST; 4 micrograms/2 microliters) or somatostatin antiserum (SST-AB; 2 microliters) 1 hr before the retention test. Decortication alone decreased the latency in comparison to that in the sham-operated group, and ICV treatment did not influence this impairment. After treatment with SST-AB the latency decreased, indicating that endogenous SST may play a role in the maintenance of normal memory processes.
Romanova
G A
GA
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Karganov
M Y
MY
Kadar
T
T
Telegdy
G
G
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology*
D013004:Somatostatin