Repeated stressful experiences differently affect brain dopamine receptor subtypes.
The binding of tritiated spiperone (D2 antagonist) and tritiated SCH 23390 (D1 antagonist), in vivo, was investigated in the caudatus putamen (CP) and nucleus accumbens septi (NAS) of mice submitted to ten daily restraint stress sessions. Mice sacrificed 24 hr after the last stressful experience presented a 64% decrease of D2 receptor density (Bmax) but no changes in D1 receptor density in the NAS. In the CP a much smaller (11%) reduction of D2 receptor density was accompanied by a 10% increase of D1 receptors. These results show that the two types of dopamine (DA) receptors adapt in different or even opposite ways to environmental pressure, leading to imbalance between them.
Puglisi-Allegra
S
S
Istituto di Psicobiologia e Psicofarmacologia (CNR), Roma, Italy.
Kempf
E
E
Schleef
C
C
Cabib
S
S
D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D018492:Dopamine Antagonists; D007650:Ketanserin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009714:Nucleus Accumbens / Q000378:metabolism / Q000648:ultrastructure; D011954:Receptors, Dopamine / Q000145:classification / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D014316:Tritium
D001552:Benzazepines; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D014316:Tritium; D013134:Spiperone; D007650:Ketanserin