The effect of an antacid and food on the absorption of cimetidine and ranitidine.
The effect of varying doses of a liquid antacid preparation containing magnesium hydroxide, aluminum hydroxide and simethicone on the absorption of the H2-receptor antagonists, cimetidine and ranitidine, was determined in 2 groups of 11 volunteers; one group fasted and one group fed a standardized breakfast. The antacid alone caused a significant decrease in the AUC of cimetidine (24%). Similarly, concomitant antacid caused a 59% decrease in the AUC of ranitidine. There were no effects on any of the other pharmacokinetic parameters examined. The absorption of both drugs was similar in fasted and fed volunteers, but in the fed volunteers the antacid did not produce the decrease in AUC seen in the fasted volunteers. These data suggest that H2-receptor antagonists should not be taken at the same time as antacids.
Desmond
P V
PV
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia.
Harman
P J
PJ
Gannoulis
N
N
Kamm
M
M
Mashford
M L
ML
D000293:Adolescent; D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000863:Antacids / Q000494:pharmacology*; D002927:Cimetidine / Q000493:pharmacokinetics*; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008276:Magnesium Hydroxide / Q000494:pharmacology; D008297:Male; D011899:Ranitidine / Q000493:pharmacokinetics*; D012841:Simethicone / Q000494:pharmacology
D000863:Antacids; D000536:Aluminum Hydroxide; D002927:Cimetidine; D012841:Simethicone; D011899:Ranitidine; D008276:Magnesium Hydroxide