Establishment of a reference interval for beta 2-microglobulin in cerebrospinal fluid with use of two commercial assays.
Increased concentrations of beta 2-microglobulin in cerebrospinal fluid have been used to detect central nervous system involvement with metastatic cancer and with neurological complications of AIDS. However, no adequate reference interval study has been reported for beta 2-microglobulin in cerebrospinal fluid. We established a reference interval with both the Abbott IMx microparticle enzyme-linked immunoassay (EIA) (0.6-2.0 mg/L) and the Pharmacia beta 2-micro EIA 96 method (0.8-2.2 mg/L) for beta 2-microglobulin in cerebrospinal fluid. The two methods correlate well, with the latter method giving slightly higher values. beta 2-Microglobulin increases with age in adults by about 0.1 mg/L every 7.5 years, with no significant difference between genders.
Lutz
C T
CT
Department of Pathology, University of Iowa, Iowa City 52242.
Cornell
S H
SH
Goeken
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D012016:Reference Values; D012727:Sex Characteristics; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D011933:Reagent Kits, Diagnostic; D001613:beta 2-Microglobulin