title: A disintegration test for vaginal tablets: comparison with BP test.
abstract: To improve the disintegration test for vaginal tablets described in the British Pharmacopoeia (BP), a monitoring apparatus was added, and tested with seven effervescent and five non-effervescent tablets. A tablet was placed on the metal disc of the BP disintegration apparatus, and the guided plate was placed on the tablet. The guided plate moved downward smoothly in a cylinder as the tablet disintegrated. The movement was recorded by using a kymograph. The end-point and process of disintegration of the tablet were automatically recorded and the results obtained suggest that the modified test is a useful tool for the quality control of vaginal tablets.
authors.affiliation: Department of Pharmacy, Niigata Prefectural Muikamachi Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Tanno
authors.forename: K
authors.initials: K
authors.lastname: Sugibayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D005260:Female; D006801:Humans; D010602:Pharmacopoeias as Topic; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation*; D006113:United Kingdom; D014621:Vagina
chemical_list: D013607:Tablets