Lipopolysaccharide from Klebsiella pneumoniae inhibits Na+ absorption in canine tracheal epithelium.
The effect of lipopolysaccharide (LPS) from Klebsiella pneumoniae on the bioelectric properties of canine cultured tracheal epithelium was examined. LPS decreased short-circuit current (Isc), and its effects on Isc were reduced when Isc was inhibited by amiloride and indomethacin. We speculate that LPS may selectively inhibit Na+ absorption through the inhibition of prostaglandin synthesis by airway epithelium.
Tamaoki
J
J
First Department of Medicine, Tokyo Women's Medical College, Japan.
Sakai
N
N
Isono
K
K
Kanemura
T
T
Takeyama
K
K
Takizawa
T
T
D000042:Absorption; D000818:Animals; D002478:Cells, Cultured; D002712:Chlorides / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis; D004285:Dogs; D004848:Epithelium / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000378:metabolism* / Q000472:pathogenicity; D008070:Lipopolysaccharides / Q000633:toxicity*; D012964:Sodium / Q000378:metabolism*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism*
D002712:Chlorides; D008070:Lipopolysaccharides; D012964:Sodium; D015232:Dinoprostone