A genetic study of human interferon-alpha-induced repair of DNA damage in hepatitis B patients.
In vitro treatment with human interferon-alpha (HuIFN-alpha) of hepatitis B virus-infected peripheral lymphocytes from 17 hepatitis B patients induced a decrease in the frequency of sister-chromatid exchanges (SCE). There was a significant difference in mean SCE frequencies between the HuIFN-alpha-treated patients and the control group, but not between acute and chronic hepatitis B patients treated with HuIFN-alpha.
Wang
P L
PL
Department of Biology, Tsingtao Medical College, People's Republic of China.
Cong
S Y
SY
Dong
X Y
XY
Chen
Z C
ZC
Ma
C P
CP
D000328:Adult; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D005260:Female; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D008297:Male; D012854:Sister Chromatid Exchange / Q000187:drug effects
D007370:Interferon Type I