title: c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13).
abstract: Molecular and cytogenetic analyses were performed on chronic B-lymphocytic cell leukemia (CLL) from a 57-year-old male patient with del(12)(p13) anomaly. The deletion did not remove the K-ras-2 gene. However, c-myc gene amplification correlated with high-level expression, suggesting the involvement of this gene in the induction of neoplasia in this patient.
authors.affiliation: Department of Molecular Oncology, Alton Ochsner Medical Foundation, New Orleans, LA 70121.
authors.forename: T Y
authors.initials: TY
authors.lastname: Wang
authors.forename: D M
authors.initials: DM
authors.lastname: Samples
authors.forename: R
authors.initials: R
authors.lastname: Dabdoub
authors.forename: O
authors.initials: O
authors.lastname: Prakash
mesh_terms: D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged