title: Early blood pressure control improves pregnancy outcome in primigravid women with mild hypertension.
abstract: OBJECTIVE
  The aim of this study was to evaluate treatment of mild to moderate hypertension (less than 170/110 mmHg) in pregnancy in a prospective, randomised, double-blind trial.
  
  
  METHODS
  Pregnancy outcome was studied for 52 primigravid women, managed in hospital from early in the third trimester.
  
  
  METHODS
  Patients were randomly allocated either to placebo or to active treatment (clonidine plus hydralazine).
  
  
  RESULTS
  Maternal deterioration dictated withdrawal from trial therapy for eight patients receiving placebo, but for only one receiving active treatment. Maternal proteinuria occurred only in the placebo group. Intention-to-treat analysis showed a significant increase in premature delivery for complications in the placebo group (P less than 0.05), despite active blood pressure treatment for those withdrawn from the group because of severe hypertension (170/110 mmHg or higher). Neonatal respiratory distress requiring intensive care occurred only in babies born to women in the placebo group. There were no perinatal deaths and no adverse effects of treatment in the neonates.
  
  
  CONCLUSIONS
  The study indicates that early control of mild hypertension in pregnancy can prevent progression to emergency premature delivery.
authors.affiliation: Department of Renal Medicine, Royal Prince Alfred Hospital, Camperdown, NSW.
authors.forename: A F
authors.initials: AF
authors.lastname: Phippard
authors.forename: W E
authors.initials: WE
authors.lastname: Fischer
authors.forename: J S
authors.initials: JS
authors.lastname: Horvath
authors.forename: A G
authors.initials: AG
authors.lastname: Child
authors.forename: A R
authors.initials: AR
authors.lastname: Korda
authors.forename: D
authors.initials: D
authors.lastname: Henderson-Smart
authors.forename: G G
authors.initials: GG
authors.lastname: Duggin
authors.forename: D J
authors.initials: DJ
authors.lastname: Tiller
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005865:Gestational Age; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000517:prevention & control*; D007231:Infant, Newborn; D008991:Monitoring, Physiologic / Q000379:methods; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third
chemical_list: D006830:Hydralazine; D003000:Clonidine