title: Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
abstract: Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study. Both drugs led to statistically significant and similar improvements in scores on the Yale-Brown Obsessive-Compulsive Rating Scale and other obsessive-compulsive and depression scales. This preliminary result warrants further exploration with a larger sample and other serotonergic agents.
authors.affiliation: Laboratory of Clinical Science, NIMH, NIH, Bethesda, Md.
authors.forename: M T
authors.initials: MT
authors.lastname: Pato
authors.forename: T A
authors.initials: TA
authors.lastname: Pigott
authors.forename: J L
authors.initials: JL
authors.lastname: Hill
authors.forename: G N
authors.initials: GN
authors.lastname: Grover
authors.forename: S
authors.initials: S
authors.lastname: Bernstein
authors.forename: D L
authors.initials: DL
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D002065:Buspirone / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D002997:Clomipramine; D002065:Buspirone