[The changes in the enzymatic activity of glutathione metabolism in immobilization stress and their possible significance].
Immobilization of rats for 20 minutes and for 4 hours activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, but inhibits gamma-glutamyl transferase in the liver and kidneys. Most of these changed values become normalized one hour after cessation of 4-hour stress. Propranolol completely prevents activation of glutathione peroxidase and glutathione transferase by stress. The changes in the activity of the glutathione metabolism enzymes are evidently of a protective character in relation to lipid peroxidation.
Kolesnikov
L S
LS
Mantorova
N S
NS
Shapiro
L A
LA
Kulinskiĭ
V I
VI
D000818:Animals; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000201:enzymology*; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005979:Glutathione Peroxidase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione