Isolation of geodiatoxins 2-4 from the marine sponge Geodia mesotriaena.
1. In a previous study of the marine sponge Geodia mesotriaena von Lendenfeld for antineoplastic constituents, evidence was obtained for the presence of several toxins and geodiatoxin 1 was isolated. 2. Further separations guided by bioassay using CDF1 mice have led to the isolation of three additional chromoprotein toxins lethal at 8 mg/kg.
Pettit
G R
GR
Department of Chemistry, Arizona State University, Tempe 85287-1604.
Rideout
J A
JA
Hasler
J A
JA
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy; D008387:Marine Toxins / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D011161:Porifera / Q000032:analysis*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008387:Marine Toxins