Stimulants of ileal salt transport in neuroendocrine system of the desert locust.
Proteinaceous factors from the corpora cardiaca (CC) and ventral ganglia (VG) stimulate KCl transport across voltage-clamped preparations of locust ilea in a dose-dependent manner. These factors may act via cAMP as the second messenger because this cyclic nucleotide and agents which increase its cellular level all mimic the stimulatory effects of CC and VG extracts. The CC and VG factors are apparently different compounds because they differ in the time course of ileal short-circuit current (Isc) initiated, in heat stability, and in extraction properties. Because saline extracts of the CC have similar effects on both ileal and rectal segments of locust hindgut, the ileal stimulant from the CC may be the chloride transport-stimulating hormone, described by Phillips et al. (Canad. J. Zool. 58, 1851-1860, 1980) which acts to stimulate rectal Isc.
Audsley
N
N
Department of Zoology, University of British Columbia, Vancouver, Canada.
Phillips
J E
JE
D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000737:chemistry / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology; D006152:Cyclic GMP / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005724:Ganglia / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D006110:Grasshoppers / Q000502:physiology*; D007082:Ileum / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D007301:Insect Hormones / Q000502:physiology; D009490:Neurosecretory Systems / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000494:pharmacology; D011189:Potassium Chloride / Q000493:pharmacokinetics*; D011506:Proteins / Q000032:analysis / Q000494:pharmacology*; D012007:Rectum / Q000187:drug effects / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D013696:Temperature; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors; D014020:Tissue Extracts / Q000502:physiology
D007301:Insect Hormones; D018377:Neurotransmitter Agents; D011506:Proteins; D014020:Tissue Extracts; D005576:Colforsin; D011189:Potassium Chloride; D013806:Theophylline; D000242:Cyclic AMP; D010447:Peptide Hydrolases; D006152:Cyclic GMP