title: Use of recombinant human erythropoietin to enhance autologous blood donation in a patient with multiple red cell allo-antibodies and the anemia of chronic disease.
abstract: We treated a patient with alcohol-induced cirrhosis, intractable pain from a defective hip prosthesis, and multiple red cell allo-antibodies with recombinant human erythropoietin (EPO) in order to facilitate collection of blood for autologous transfusion during an elective total hip revision. This patient had experienced a delayed transfusion reaction 4 months earlier after receiving least incompatible packed red cells for gastrointestinal bleeding. His blood could not be crossmatched because of the development of multiple antibodies to homologous blood given during previous surgery and several episodes of gastrointestinal hemorrhage. Following initiation of EPO therapy, there was a prompt and persistent increase in the reticulocyte count from a baseline of 1.6% to a maximum of 8.6%. This was accompanied by maintenance of the hematocrit between 32% and 38.5% despite withdrawal of seven units of autologous blood over the 45-day treatment period. Poor venous access and availability of blood bank personnel, not hematocrit level, were the limiting factors that determined how frequently blood could be collected. We conclude that EPO stimulated erythropoiesis in this patient with underlying anemia of chronic disease and facilitated harvest of autologous blood for elective surgery.
authors.affiliation: Department of Medicine, Veterans Administration Medical Center, Nashville, Tennessee 37212.
authors.forename: F L
authors.initials: FL
authors.lastname: Thompson
authors.forename: J S
authors.initials: JS
authors.lastname: Powers
authors.forename: S E
authors.initials: SE
authors.lastname: Graber
authors.forename: S B
authors.initials: SB
authors.lastname: Krantz
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D002908:Chronic Disease; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology*; D004921:Erythropoietin / Q000627:therapeutic use*; D006622:Hip Prosthesis; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D011475:Prosthesis Failure; D011994:Recombinant Proteins; D012086:Reoperation
chemical_list: D007518:Isoantibodies; D011994:Recombinant Proteins; D004921:Erythropoietin