title: Exudative retinal detachment after photodynamic injury.
abstract: Exudative retinal detachments occur in a variety of retinal and choroidal diseases. We created serous retinal detachment in the cat eye by means of photodynamic injury produced by activation of intravascular rose bengal using filtered, focused light (550 nm). Fluorescein angiography later revealed focal retinal and choroidal vascular occlusion surrounded by a larger area of leakage through the pigment epithelium. Serous retinal detachments occurred rapidly, gradually enlarged over the next 3 days, and resolved in all eyes after 14 to 21 days. Histopathologic and ultrastructural features of early lesions included the accumulation of proteinaceous fluid in the subretinal space, pigment epithelial cell damage, and localized occlusion of retinal vessels and the choriocapillaris. Later changes consisted of limited regeneration of the retina and portions of the tapetum. In several respects, these experimental detachments resemble the serous retinal detachments associated with choroidal ischemia in humans, and may serve as a useful model in the study of choroidal microvascular hypoperfusion.
authors.affiliation: Veterans Administration Medical Center, Durham, NC.
authors.forename: C A
authors.initials: CA
authors.lastname: Wilson
authors.forename: A J
authors.initials: AJ
authors.lastname: Royster
authors.forename: J S
authors.initials: JS
authors.lastname: Tiedeman
authors.forename: D L
authors.initials: DL
authors.lastname: Hatchell
mesh_terms: D000818:Animals; D002415:Cats; D002829:Choroid / Q000098:blood supply / Q000648:ultrastructure; D004195:Disease Models, Animal; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D008297:Male; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D012163:Retinal Detachment / Q000139:chemically induced / Q000473:pathology*; D012171:Retinal Vessels / Q000648:ultrastructure; D012395:Rose Bengal
chemical_list: D012395:Rose Bengal