Adriamycin-induced neoplastic lesions in the Egyptian toad Bufo regularis.
Injecting adult toads (Bufo regularis) subcutaneously in the dorsal lymph sac with adriamycin at a dose of 2 mg/kg body weight, once every 3 weeks for 20 weeks, induced hepatocellular carcinomas in 20 out of 100 animals. Metastases of the primary liver tumors appeared in the kidneys of 7 toads.
el-Mofty
M M
MM
Department of Zoology, Faculty of Science, University of Alexandria, Egypt.
Khudoley
V V
VV
Sakr
S A
SA
Osman
S I
SI
Toulan
B A
BA
D000818:Animals; D002025:Bufonidae; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000556:secondary; D008297:Male
D004317:Doxorubicin