[Increase of the number of bone marrow T-suppressor cells under inhibition of immunogenesis during changes of the activity of the neuromediator system].
Increase of serotoninergic system activity and blockade of dopaminergic system activity led to the change of T- and B-lymphocyte distribution in immunocompetent organs of non-immunized animals. Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP. Role of bone marrow in neuro-immunomodulation is discussed.
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D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology*; D001854:Bone Marrow Cells; D015259:Dopamine Agents / Q000494:pharmacology; D007958:Leukocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D020280:Sertraline; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D015259:Dopamine Agents; D018377:Neurotransmitter Agents; D010880:Piperidines; D012702:Serotonin Antagonists; D015057:1-Naphthylamine; C026539:preclamol; D020280:Sertraline