Region-specific noradrenaline depletion by neonatal DSP-4: functional consequences and effect on a coexisting neurotransmitter.
Noradrenaline (NA) depletion following neonatal treatment of rats with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzyl-amine) was not accompanied by any changes in neuropeptide tyrosine (NPY) levels. After 85-95% NA depletion in the spinal cord of DSP-4-treated rats, the reaction time in the tail withdrawal test was shorter than in the controls but the endogenous activation of the sympathetic nervous system in the baroreceptor reflex remained unchanged. These results suggest that the NA neurons in the spinal cord have an inhibitory function the processing of incoming sensory information.
Donnerer
J
J
Department of Experimental and Clinical Pharmacology, University of Graz, Austria.
Amann
R
R
Skofitsch
G
G
Lembeck
F
F
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001596:Benzylamines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006339:Heart Rate / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011311:Pressoreceptors / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D001596:Benzylamines; D018377:Neurotransmitter Agents; D014443:Tyrosine; C012102:DSP 4; D009638:Norepinephrine