title: Correlation of isomeric fatty acids in human adipose tissue with clinical risk factors for cardiovascular disease.
abstract: The relationships between the adipose tissue concentrations of 19 geometric and positional fatty acid isomers and 10 cardiovascular disease risk factors were determined in 76 free-living adult males. The percentages for trans isomers (total mean +/- SD 4.14 +/- 0.97%) and cis isomers (total mean +/- SD 2.91 +/- 0.34%) in adipose tissue generally agreed with dietary estimates based on the consumption of hydrogenated oils. A major exception was the percentage of 11c-18:1, which was twofold higher in adipose tissue. The total level of fatty acid isomers in adipose tissue or a factor (derived by factor analysis) that was representative of isomers of dietary origin was not significantly correlated with the cardiovascular risk factors. Only three trans isomers (11t-18:1, 12t-18:1, and 5t-14:1) and three cis isomers (11c-18:1, 13c-18:1, and 7c-16:1) were weakly correlated either positively or negatively with age, body mass index, plasma and lipoprotein cholesterol, and/or blood pressure (P less than 0.05, r greater than 0.231).
authors.affiliation: Rockefeller University, New York, New York.
authors.forename: L C
authors.initials: LC
authors.lastname: Hudgins
authors.forename: J
authors.initials: J
authors.lastname: Hirsch
authors.forename: E A
authors.initials: EA
authors.lastname: Emken
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D002849:Chromatography, Gas; D005163:Factor Analysis, Statistical; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013237:Stereoisomerism
chemical_list: D005227:Fatty Acids