The degree of genetic disparity between donor and host correlates with survival of intraventricular substantia nigra grafts.
We have evaluated the degree of genetic disparity that permits survival of intraventricular brain tissue grafts without additional immunosuppression. Fisher 344 rats (n = 100) with unilateral substantia nigra lesions were used as hosts. Donors consisted of Fischer 344 rats (isografts), Sprague-Dawley rats (allografts), mice, hamsters, and rabbits (xenografts). Grafts were obtained from the ventral mesencephalon of embryonic animals. The functional properties of the grafts were measured by behavioral rotation tests. Frequency of graft survival determined histologically was related to the degree of genetic disparity between donor and host. In comparing rabbit and hamster xenografts, the greater degree of disparity for the rabbit-to-rat grafts was associated with a shorter period of behavioral recovery (3 weeks vs. 5 to 6 weeks) after transplantation. It is concluded that rejection of intracerebral brain tissue grafts does not occur as an all-or-none process, but instead varies as a function of the degree of genetic disparity between donor and host.
Dymecki
J
J
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland.
Poltorak
M
M
Freed
W J
WJ
D000818:Animals; D006224:Cricetinae; D006084:Graft Rejection; D006085:Graft Survival; D051379:Mice; D009043:Motor Activity; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D012399:Rotation; D013378:Substantia Nigra / Q000637:transplantation*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D014446:Tyrosine 3-Monooxygenase