[A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever].
Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction.
Wang
G Q
GQ
Department of Infectious Diseases, First Affiliated Hospital, Harbin Medical University.
Zou
Z Z
ZZ
Yu
D P
DP
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D000368:Aged; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha