title: Zinc acexamate inhibits gastric acid and pepsinogen secretion in the rat.
abstract: Pretreatment with zinc acexamate (25-100 mg kg-1 i.p.) inhibited acid and pepsinogen secretion in the pylorus-ligated rat. Zinc acexamate (5-50 mg kg-1 p.o.) also inhibited the increases in acid secretion induced by carbachol (10 micrograms kg-1) and 2-deoxy-D-glucose (200 mg kg-1) in the perfused stomach of the anaesthetized rat. A delayed antisecretory effect was observed with this drug on histamine induced responses. High concentrations of zinc acexamate (10(-5) - 10(-2) M) did not modify the in-vitro activity of pepsin. Administration of zinc acexamate resulted in an increase in the presence of pepsinogen at the mucosal level. A morphological examination of the gastric mucosa confirmed an accumulation of zymogen-containing granules in the gastric chief cells of zinc acexamate-treated rats (50 mg kg-1 p.o.). These results indicate that zinc acexamate decreases acid and pepsinogen secretion in-vivo, and this may explain its antiulcer activity.
authors.affiliation: Departamento de Farmacología, Laboratorios Viñas S.A., Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Bulbena
authors.forename: J V
authors.initials: JV
authors.lastname: Esplugues
authors.forename: G
authors.initials: G
authors.lastname: Escolar
authors.forename: L
authors.initials: L
authors.lastname: Gil
authors.forename: C
authors.initials: C
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Esplugues
mesh_terms: D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D010435:Pepsinogens / Q000378:metabolism*; D010477:Perfusion; D011708:Pylorus / Q000502:physiology; D051381:Rats
chemical_list: D000614:Aminocaproates; D010435:Pepsinogens; C018802:6-acetylaminocaproic acid; D015119:Aminocaproic Acid