title: Fluoxetine treatment of cocaine abuse in heroin addicts.
abstract: The authors administered fluoxetine to 11 cocaine-abusing heroin addicts entered in a methadone maintenance program to determine whether it would decrease cocaine craving and use. Three patients discontinued treatment within a few days of initiation because of lack of any acute therapeutic effect. The remaining 8 received fluoxetine for at least 1 week and were followed up over 1 to 6 months. Of these 8, 5 (63%) were successfully treated for cocaine abuse. Three case examples are presented. Fluoxetine may prove a useful addition to the therapeutic armamentarium in the treatment of cocaine abuse.
authors.affiliation: Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
authors.forename: M H
authors.initials: MH
authors.lastname: Pollack
authors.forename: J F
authors.initials: JF
authors.lastname: Rosenbaum
mesh_terms: D000328:Adult; D003042:Cocaine; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006556:Heroin Dependence / Q000150:complications* / Q000523:psychology / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000523:psychology / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000523:psychology
chemical_list: D005473:Fluoxetine; D003042:Cocaine; D008691:Methadone