Modification of pain on injection of propofol--a comparison between lignocaine and procaine.
Pain on injection of propofol was assessed in a controlled, randomised study of 273 patients. They received either lignocaine 10 mg, procaine 10 mg or isotonic saline 0.5 ml, 15 seconds before the injection of propofol into a vein on the back of the hand. The incidence of pain on injection in the control group (51%) was comparable with other studies. Lignocaine and procaine both significantly reduced the pain (35% and 34% respectively, p less than 0.05) but there was no statistical difference between these two groups.
Nicol
M E
ME
Royal Marsden Hospital, London.
Moriarty
J
J
Edwards
J
J
Robbie
D S
DS
A'Hern
R P
RP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000772:Anesthesia, Local; D006801:Humans; D008012:Lidocaine; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011184:Postoperative Period; D011343:Procaine; D015742:Propofol / Q000009:adverse effects*
D011343:Procaine; D008012:Lidocaine; D015742:Propofol