Neuronal uptake of noradrenaline in the rat isolated trachea: effect of ageing.
1. The neuronal uptake of 3H-noradrenaline in isolated trachea strips of the rat was analysed from cocaine-resistant 2 min accumulation of 3H-noradrenaline from reserpine pre-treated animals. 2. Neuronal uptake of 3H-noradrenaline was demonstrated to exist in isolated trachea of rats at different ages (4, 12 and 20 months old). 3. The determination of kinetic parameter values (Vmax and apparent Km) of neuronal 3H-noradrenaline uptake indicated that this transport process was not modified by ageing.
de Avellar
M C
MC
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Markus
R P
RP
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D004351:Drug Resistance / Q000502:physiology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014132:Trachea / Q000294:innervation*; D014316:Tritium
D014316:Tritium; D012110:Reserpine; D003042:Cocaine; D009638:Norepinephrine