Biperiden and piroheptine do not affect the serum level of zotepine, a new antipsychotic drug.
The effects of biperiden and piroheptine on the serum level of zotepine were studied in 15 schizophrenic and 6 mentally retarded in-patients. Neither of these anticholinergic drugs affected the serum level of zotepine nor caused significant side-effects. In the schizophrenics the total scores on the BPRS did not change significantly with either combination of drugs.
Otani
K
K
Department of Neuropsychiatry, Hirosaki University Hospital, Japan.
Hirano
T
T
Kondo
T
T
Kaneko
S
S
Fukushima
Y
Y
Noda
K
K
Tashiro
Y
Y
D000328:Adult; D014150:Antipsychotic Agents; D001712:Biperiden / Q000008:administration & dosage*; D003986:Dibenzocycloheptenes / Q000008:administration & dosage*; D003988:Dibenzothiepins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D011759:Pyrrolidines / Q000008:administration & dosage*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D003988:Dibenzothiepins; D010880:Piperidines; D011759:Pyrrolidines; D001712:Biperiden; C055566:piroheptine; C022172:zotepine