Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder.
Eighteen outpatients with obsessive-compulsive disorder were treated with either buspirone, a partial serotonin agonist, or clomipramine, a serotonin uptake inhibitor, in a double-blind, random-assignment study. Both drugs led to statistically significant and similar improvements in scores on the Yale-Brown Obsessive-Compulsive Rating Scale and other obsessive-compulsive and depression scales. This preliminary result warrants further exploration with a larger sample and other serotonergic agents.
Pato
M T
MT
Laboratory of Clinical Science, NIMH, NIH, Bethesda, Md.
Pigott
T A
TA
Hill
J L
JL
Grover
G N
GN
Bernstein
S
S
Murphy
D L
DL
D000328:Adult; D000553:Ambulatory Care; D002065:Buspirone / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
D002997:Clomipramine; D002065:Buspirone