title: [The effect of the new Soviet antihistamine and antiserotonin preparation bikarfen on the central nervous system].
abstract: The effect of an antiallergic (antihistaminic and antiserotonin) drug bicarphen on the functional state of the central nervous system (CNS) was studied. In experiments on animals bicarphen in contrast to dimedrol (diphenhydramine) exerted predominantly the activating effect on CNS (decreased the hypnotic action of barbamyl, enhanced the summation capacity of CNS and the activity of mice in the escape behavioral test, increased the bioelectrical activity of the brain and the activating effect of antidepressants on the EEG).
authors.forename: M E
authors.initials: ME
authors.lastname: Kaminka
authors.forename: N E
authors.initials: NE
authors.lastname: Kuksgauz
authors.forename: N I
authors.initials: NI
authors.lastname: Andreeva
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002227:Carbazoles / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D004155:Diphenhydramine / Q000494:pharmacology; D004347:Drug Interactions; D004594:Electrophysiology; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects; D011812:Quinuclidines / Q000494:pharmacology*; D011817:Rabbits; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D002227:Carbazoles; D002243:Carbolines; D006634:Histamine H1 Antagonists; D011812:Quinuclidines; D012702:Serotonin Antagonists; C027473:metralindole; C018139:bicarphene; D004155:Diphenhydramine; C009830:pirlindole