Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy.
Verapamil was shown to be capable of increasing intracellular daunorubicin levels in normal lymphocytes isolated from patients undergoing chemotherapy for epithelial ovarian cancer. The extent of the increase in daunorubicin accumulation was variable, occurring in the range of 0-123% as compared with intracellular daunorubicin levels attained in the absence of verapamil. No similar effect was seen in lymphocytes isolated from healthy volunteers. A tentative explanation of these data may be the induction of multidrug resistance (mdr)-like characteristics in normal lymphocytes following cytotoxic chemotherapy.
McGown
A T
AT
CRC Department of Experimental Chemotherapy, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Murphy
D
D
Crowther
D
D
Fox
B W
BW
D003630:Daunorubicin / Q000378:metabolism* / Q000627:therapeutic use; D004848:Epithelium; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D003630:Daunorubicin