[In vitro chemosensitivity test with several antitumor agents against eight malignant brain tumor cell-lines].
We performed an in vitro chemosensitivity test with 8 malignant brain tumor cell lines, which were established in our Department. It was shown that ACNU was moderately tumoricidal against only one cell (ONS-86) line. IFN-beta (interferon-beta) was more active against 4 cell (ONS-6, -20, -76, and -81) lines. VCR (vincristine), MTX (methotrexate), and Ara-C (cytosine arabinoside) and FK 973 were most effective against all 8 cell lines. There were some difference in the drug sensitivities among the tumors with the same pathological diagnosis. Since IFN-beta was tumoricidal against to the cells, co-culture of IFN-beta and one of other antitumor agents seemed to induce more antitumor effects. With regard to the side effects of IFN-beta, the combined therapy with IFN-beta and other drugs induced more antitumor effects against malignant brain tumor cells and seemed to reduce the side effects.
Mabuchi
E
E
Dept. of Neurosurgery, Osaka University Medical School, Japan.
Shimizu
K
K
Yamada
M
M
Moriuchi
S
S
Park
K
K
Tamura
K
K
Hayakawa
T
T
Mogami
H
H
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D015376:Nimustine / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D007370:Interferon Type I; D015376:Nimustine; D014750:Vincristine; D008727:Methotrexate