Mutational analysis of the carboxyl terminus of the Moloney murine leukemia virus integration protein.
The integration protein (IN) is required for retrovirus DNA integration into the host DNA. The function of the C terminus of the Moloney murine leukemia virus IN protein was examined. The terminal 28 amino acids were found to be nonessential. A linker insertion at position 6025, within a 36-amino-acid insertion not found in any other retrovirus, also produced viable virus.
Roth
M J
MJ
Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.
D000818:Animals; D001287:Attachment Sites, Microbiological; D002478:Cells, Cultured; D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000235:genetics*; D004279:DNA, Viral / Q000378:metabolism*; D019426:Integrases; D008979:Moloney murine leukemia virus / Q000235:genetics* / Q000254:growth & development; D009154:Mutation; D051381:Rats; D014779:Virus Replication
D004279:DNA, Viral; D004254:DNA Nucleotidyltransferases; D019426:Integrases