title: Jejunal efflux in short bowel syndrome.
abstract: 24 h oral intake and intestinal output were studied in 15 patients with a short residual length of jejunum and no colon. 8 patients showed a net secretory, and 7 a net absorptive response to food. In secretors, daily intestinal output exceeded oral intake (mean 2.3 kg wet weight, and 233 mmol sodium). Long-term parenteral fluid and electrolyte replacements were needed only in those with a secretory response. Jejunal length inversely correlated with net intestinal output of fluid, sodium, potassium, and with percentage energy absorption. A secretory response was observed if jejunal length was less than 100 cm and was reduced by gastric antisecretory drugs and octreotide.
authors.affiliation: St Mark's Hospital, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Nightingale
authors.forename: J E
authors.initials: JE
authors.lastname: Lennard-Jones
authors.forename: E R
authors.initials: ER
authors.lastname: Walker
authors.forename: M J
authors.initials: MJ
authors.lastname: Farthing
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D005502:Food; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects; D007582:Jejunostomy; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008286:Malabsorption Syndromes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000494:pharmacology; D009853:Omeprazole / Q000494:pharmacology; D010288:Parenteral Nutrition; D011188:Potassium / Q000378:metabolism*; D011899:Ranitidine / Q000494:pharmacology; D012778:Short Bowel Syndrome / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012964:Sodium / Q000378:metabolism*
chemical_list: D011899:Ranitidine; D012964:Sodium; D009853:Omeprazole; D015282:Octreotide; D011188:Potassium