A case of basophilic leukemia bearing simultaneous translocations t(8;21) and t(9;22).
We report a case of basophilic leukemia with simultaneous translocations of t(8;21) and t(9;22). The patient's clinical and hematologic findings were characteristic only of t(9;22) but not of t(8;21). This unusual cytogenetic phenomenon raises a challenge to the current concepts of primary chromosomal abnormalities in cancer.
Xue
Y Q
YQ
Jiangsu Institute of Hematology, Leukemia Research Unit, Suzhou Medical College, China.
Guo
Y
Y
Lu
D R
DR
Gu
J
J
Lu
D W
DW
Gong
J X
JX
Wang
M H
MH
Zhu
W Y
WY
Lin
B J
BJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002891:Chromosomes, Human, Pair 21; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D011241:Prednisone / Q000627:therapeutic use; D014178:Translocation, Genetic; D014750:Vincristine / Q000627:therapeutic use
D004338:Drug Combinations; D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone