title: Effect of platelet derived growth factor on heterotopic bone formation in rats.
abstract: Platelet derived growth factor (PDGF) and induction of newly woven bone growth were studied in rats. PDGF (20 ng/mL) was administered continuously for 2 weeks via micro-osmotic pumps to 6-mm-long pieces of demineralized rat femur inserted into muscle pouches. Each rat had a control piece of demineralized bone inserted into the contralateral gluteal muscle. The samples were collected after 4 weeks, and wet and ash weight were recorded. Fourteen rats were evaluated. There were no differences as regards wet weights. PDGF increased the ash weights.
authors.affiliation: Department of Orthopedics, University Hospital, Linköping, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Risto
authors.forename: O
authors.initials: O
authors.lastname: Wahlström
authors.forename: A
authors.initials: A
authors.lastname: Abdiu
authors.forename: T
authors.initials: T
authors.lastname: Walz
mesh_terms: D000818:Animals; D001842:Bone and Bones; D002828:Choristoma / Q000503:physiopathology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D051381:Rats; D012983:Soft Tissue Neoplasms / Q000503:physiopathology*
chemical_list: D010982:Platelet-Derived Growth Factor