title: [Changes in intraocular pressure and aqueous humor dynamics of normal human eyes after topical application of bunazosin hydrochloride].
abstract: The effects of topically applied bunazosin hydrochloride, a recently developed highly selective alpha 1-adrenergic antagonist, on intraocular pressure, pupillary diameter, aqueous protein concentration, anterior chamber volume, aqueous flow rate and tonographic outflow facility were investigated in eight normal human volunteers. A single application of 0.1% bunazosin hydrochloride caused a significant unilateral reduction in the intraocular pressure from 30 minutes through 4 hours after the application, with a maximum decrease of 2.0 +/- 0.5mmHg (mean +/- SEM) below the contralateral control eyes at 2 hours post-application. Neither pupillary diameter, anterior chamber volume nor outflow facility was affected by the drug application. Both aqueous protein concentration measured with a flare-cell meter and aqueous flow rate determined by fluorophotometry were unaltered. The mechanism of intraocular pressure reduction appears to be an increase in uveoscleral outflow and/or a decrease in episcleral venous pressure.
authors.affiliation: Eye Clinic, Tokyo Kosei Nenkin Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oshika
authors.forename: M
authors.initials: M
authors.lastname: Araie
mesh_terms: D000317:Adrenergic alpha-Antagonists; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D005136:Eye Proteins / Q000378:metabolism; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011799:Quinazolines / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D005136:Eye Proteins; D009883:Ophthalmic Solutions; D011799:Quinazolines; C018176:bunazosin