8;21 translocation with duplication of the der(21) in a patient with myelomonocytic leukemia.
An 8;21 translocation with duplication of the der(21) is described in a 72-year-old man who presented with features of chronic myelomonocytic leukemia. Progression to acute myelomonocytic leukemia occurred within one month of diagnosis. The possible prognostic significance of the t(8;21) with duplicated der(21) in myelodysplasia is discussed.
Auger
M J
MJ
Department of Haematology, Western General Hospital, Edinburgh.
Ross
F M
FM
Mackie
M J
MJ
D000368:Aged; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D005810:Multigene Family; D014178:Translocation, Genetic