title: The effect of triclofos sodium sedation on respiratory rate, oxygen saturation, and heart rate in infants and young children.
abstract: Chloral hydrate is frequently used to sedate infants for lung function testing. While no effect on respiratory function has been demonstrated, a recent study has reported a fall in oxygen saturation (SaO2) following sedation in wheezy infants. This study was designed to assess the effects of the closely related but less gastrically irritant drug triclofos sodium on respiratory rate (RR), heart rate (HR), and SaO2 in infants without cardiopulmonary disease. Paired measurements using respiratory inductance plethysmography and pulse oximetry were obtained in 10 infants (4-19 months of age) during natural and sedated sleep. Following sedation with triclofos, mean RR rose by 1.9 breaths min-1 (95% confidence intervals [Cl] of the mean difference: 0.13-3.7 min-1). Mean heart rate rose by 5.5 beats min-1 (95% Cl: -0.9-11.9 min-1). Mean SaO2 fell by 0.68% (95% Cl -1.8-0.45%). None of these changes are considered to be of clinical importance, and only the change in RR reached statistical significance at the 5% level.
authors.affiliation: Respiratory and Anaesthetic Unit, Hospital for Sick Children, London, England.
authors.forename: E A
authors.initials: EA
authors.lastname: Jackson
authors.forename: P S
authors.initials: PS
authors.lastname: Rabbette
authors.forename: C
authors.initials: C
authors.lastname: Dezateux
authors.forename: D J
authors.initials: DJ
authors.lastname: Hatch
authors.forename: J
authors.initials: J
authors.lastname: Stocks
mesh_terms: D016292:Procedural Sedation; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007223:Infant; D010755:Organophosphates / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood*; D010991:Plethysmography; D012119:Respiration / Q000187:drug effects*
chemical_list: D006993:Hypnotics and Sedatives; D010755:Organophosphates; C004345:triclofos; D010100:Oxygen