Neural transplantation in mouse Parkinson's disease.
A complete recovery from the methamphetamine-induced rotational response was shown in C57BL/6 (H-2b) mice which had had unilateral 6-OHDA lesions in the nigrostriatal pathway about 60 days after transplantation of approximately 1 x 10(6) dopamine-rich cells from syngeneic or allogeneic (C3H/HeN, H-2k) mouse embryos (ED 15), without immunosuppressive agents. Morphological examination showed tyrosine-hydroxylase-immunoreactive cell clusters around the needle tract in the mice which were transplanted not only with syngeneic cells but also with allogeneic cells. This might indicate that so-called immunosuppressive agents are not necessary for grafted embryonic cells to survive in an allogeneic mouse brain.
Shimizu
K
K
Department of Neurosurgery, Osaka University Medical School, Japan.
Yamada
M
M
Matsui
Y
Y
Tamura
K
K
Moriuchi
S
S
Mogami
H
H
D000818:Animals; D016380:Brain Tissue Transplantation / Q000276:immunology / Q000379:methods*; D003342:Corpus Striatum / Q000187:drug effects / Q000276:immunology / Q000601:surgery; D004298:Dopamine / Q000502:physiology*; D016332:Fetal Tissue Transplantation / Q000276:immunology / Q000379:methods*; D006085:Graft Survival / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D008636:Mesencephalon / Q000276:immunology / Q000637:transplantation*; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000276:immunology / Q000601:surgery*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013238:Stereotaxic Techniques; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000276:immunology / Q000601:surgery; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011954:Receptors, Dopamine; D008694:Methamphetamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine