A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.
Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).
Reddy
G R
GR
Department of Biochemistry, Tokushima University School of Medicine, Japan.
Ueda
N
N
Hada
T
T
Sackeyfio
A C
AC
Yamamoto
S
S
Hano
Y
Y
Aida
M
M
Nomura
T
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D016859:Lipoxygenase Inhibitors; D013329:Structure-Activity Relationship
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; C066727:artonin E; C057451:morusin