title: Release of vasoactive peptides from autonomic and sensory nerves.
abstract: Release of specific vasoactive peptides occurs upon activation of perivascular parasympathetic (vasoactive intestinal polypeptide and peptide histidine isoleucine), sympathetic (neuropeptide Y) and sensory (calcitonin gene-related peptide and tachykinins) nerves. These peptides may serve as cotransmitters with acetylcholine and noradrenaline with interactions both at the pre- and postjunctional levels. Some long-lasting nonadrenergic, noncholinergic vascular effects upon nerve activation may thus be peptide-mediated. Strong activation seems to be necessary for peptidergic transmission in the parasympathetic and sympathetic system while local sensory mechanisms may occur even at single impulses.
authors.affiliation: Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: J M
authors.initials: JM
authors.lastname: Lundberg
authors.forename: A
authors.initials: A
authors.lastname: Franco-Cereceda
authors.forename: J S
authors.initials: JS
authors.lastname: Lacroix
authors.forename: J
authors.initials: J
authors.lastname: Pernow
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D006801:Humans; D009475:Neurons, Afferent / Q000502:physiology*; D009478:Neuropeptide Y / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010451:Peptide PHI / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*; D015320:Tachykinins / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D010451:Peptide PHI; D015320:Tachykinins; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide