N-methyl-D-aspartate stimulates the release of dopamine from rat hippocampal slices.
Rat hippocampal slices were loaded with [14C]dopamine (DA) and superfused continuously with oxygenated Mg2(+)-free Krebs-Henseleit solution. A 5-min pulse of 1 mM N-methyl-D-aspartate (NMDA) temporarily enhanced the basal release of DA by 30%. This effect was blocked by 50 microM D,L-2-amino-5-phosphonovalerate, a selective NMDA receptor antagonist, as well as by 0.5 microM tetrodotoxin. These results suggest that NMDA receptors on hippocampal interneurons may modulate the DA release. A possible link between the NMDA-induced release of DA and mechanisms enabling the maintenance of synaptic long-term potentiation in the hippocampus is discussed.
Schröder
H
H
Institute of Pharmacology and Toxicology, Medical Academy Magdeburg, GDR.
Reymann
K G
KG
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D016202:N-Methylaspartate; D009473:Neuronal Plasticity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D013779:Tetrodotoxin; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D004298:Dopamine