[Effect of tuftsin and hydroxymethacil on tyrosine hydrolase of macrophages in chronic stress].
It has been established that rat peritoneal macrophages possess tyrosine hydroxylase activity which has been characterized by KM4, 2 microM, Vmax 30 nmole/min per mg of protein. After 15 days of electronociseptive stimulation almost all tyrosine hydroxylase activity has been established in the form which has tyrosine KM47.0 M and Vmax 18.6 nmole/min. per mg of protein. Immunostimulator hydroxymethacil++, at its intraperitoneal injections to stressed rats during 7 days induced the appearance of low-affinity form of tyrosine hydroxylase with KM270 microM and Vmax 27.8 nmole/min.per mg of protein. The same low affinity form of the enzyme has been established after injections of tuftsin which possesses immunostimulating properties.
Mineeva
M F
MF
Bulatova
N R
NR
Val'dman
A V
AV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004597:Electroshock; D066298:In Vitro Techniques; D008029:Lighting; D008264:Macrophages / Q000201:enzymology* / Q000276:immunology; D008297:Male; D051381:Rats; D013315:Stress, Psychological / Q000201:enzymology* / Q000209:etiology / Q000276:immunology; D013997:Time Factors; D014405:Tuftsin / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D014498:Uracil; C003029:oxymethacil; D014446:Tyrosine 3-Monooxygenase; D014405:Tuftsin