Somatostatin receptor imaging in vivo localization of tumors with a radiolabeled somatostatin analog.
This paper presents the results of the visualization of somatostatin (SS) receptor positive tumors in man after the i.v. administration of the SS analog Tyr3-octreotide coupled to 123I. It is an easy, quick and harmless procedure which allows imaging of primary and (often unexpected) secondary deposits and/or multiple localizations of the majority of endocrine pancreatic tumors, metastatic carcinoids and pituitary tumors, as well as of a multitude of tumors with neuroendocrine characteristics and well-differentiated brain tumors and meningiomas. In the case of hormone-secreting tumors a positive scan in most instances also predicts the subsequent successful therapy with octreotide.
Lamberts
S W
SW
Department of Internal and Nuclear Medicine, Erasmus University, Rotterdam, The Netherlands.
Bakker
W H
WH
Reubi
J C
JC
Krenning
E P
EP
D006801:Humans; D007457:Iodine Radioisotopes; D010190:Pancreatic Neoplasms / Q000556:secondary / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000556:secondary / Q000648:ultrastructure*; D017981:Receptors, Neurotransmitter / Q000648:ultrastructure*; D017481:Receptors, Somatostatin; D013004:Somatostatin / Q000032:analysis*
D007457:Iodine Radioisotopes; D017981:Receptors, Neurotransmitter; D017481:Receptors, Somatostatin; D013004:Somatostatin