Pharmacological properties of the NMDA receptor involved in somatostatin release from cortical neurons.
Glutamate increases somatostatin release from cultured cerebral cortical neurons, presumably through a N-methyl-D-aspartate (NMDA) receptor type. We report here that the NMDA response was potentiated by D-serine (10 microM) and that this potentiation was blocked by kynurenic acid (4-hydroxyquinoline-2-carboxylic acid; KYN). A higher concentration of D-serine (100 microM) reduced the antagonistic effect of KYN. Furthermore, the NMDA response exhibited another characteristic property of the NMDA receptor: it was decreased by low concentrations of Zn2+ (50 microM). In contrast, Zn2+ slightly but significantly potentiated the quisqualate (QA)- and kainate (KA)-induced responses.
Tapia-Arancibia
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L
UA 1197 CNRS, Université de Montpellier, France.
Astier
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H
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D007736:Kynurenic Acid / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D016318:Quisqualic Acid / Q000494:pharmacology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012694:Serine / Q000494:pharmacology; D013004:Somatostatin / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology
D005971:Glutamates; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; D013004:Somatostatin; D016318:Quisqualic Acid; D007736:Kynurenic Acid; D015032:Zinc; D007608:Kainic Acid