Monocyte chemotactic proteins from human tumor cells.
The production of the monocyte chemoattractant MCP-1 suggests a common mechanism for the recruitment of monocytes/macrophages and provides an explanation for monocyte/macrophage infiltration frequently observed in solid tumors. The regulated production of MCP-1 by non-transformed cells further substantiates the suggestion that MCP-1 is an important inflammatory mediator and is involved in the recruitment of monocytes in a number of pathologic or physiologic conditions.
Graves
D T
DT
Department of Oral Biology, Boston University Medical Center, MA 02118.
Valente
A J
AJ
D000818:Animals; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology*; D014407:Tumor Cells, Cultured
D018932:Chemokine CCL2; D002630:Chemotactic Factors