Role of molecular genetics in the understanding of the pathogenesis of hypertension.
Possible roles for molecular genetical approaches to understand the pathogenesis of hypertension are briefly reviewed. To elucidate observed alterations in hypertensive subjects at both molecular and systemic levels in a comprehensive way, a model (a working hypothesis) for the molecular pathogenesis of hypertension is proposed. Prospects for identifying restriction fragment length polymorphisms observed in hypertensive rats but not in normotensive rats are also discussed.
Nojima
H
H
Department of Pharmacology, Jichi Medical School, Tochigi-ken, Japan.
D000818:Animals; D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D015870:Gene Expression; D008040:Genetic Linkage; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic; D012150:Polymorphism, Restriction Fragment Length; D051381:Rats; D011918:Rats, Inbred SHR
D004247:DNA