title: Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences.
abstract: Extensive chromosome size polymorphism arises in Plasmodium berghei during in vivo mitotic multiplication. Size differences between homologous chromosomes involve rearrangements occurring in the subtelomeric portions while internal chromosomal regions do not contribute significantly to chromosome size polymorphism. Differences in the copy number of a 2.3-kb subtelomeric repeated unit are shown to correlate with size variations, and in at least one case to account completely for the size difference between two variants of the same chromosome.
authors.affiliation: Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ponzi
authors.forename: C J
authors.initials: CJ
authors.lastname: Janse
authors.forename: E
authors.initials: E
authors.lastname: Dore
authors.forename: R
authors.initials: R
authors.lastname: Scotti
authors.forename: T
authors.initials: T
authors.lastname: Pace
authors.forename: T J
authors.initials: TJ
authors.lastname: Reterink
authors.forename: F M
authors.initials: FM
authors.lastname: van der Berg
authors.forename: B
authors.initials: B
authors.lastname: Mons
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002875:Chromosomes; D005434:Flow Cytometry; D007621:Karyotyping; D008938:Mitosis; D009693:Nucleic Acid Hybridization; D010962:Plasmodium berghei / Q000166:cytology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid