Karyotype and placental structure of first-trimester spontaneous abortions: a morphometrical study.
Size of placental villi, thickness and condition of trophoblast, stromal density of villi as well as perivillous fibrinoid deposits were used as criteria for patho-morphological classification of karyotyped first-trimester spontaneous abortions. Significant differences in all the criteria were noted. Diagnostic values were verified using discriminant analysis. Using morphological values, 67% of the cases could be grouped correctly. Including further criteria (week of gestation, age of mother) it was possible to improve this to 72%. Normal karotype and trisomy could be accurately diagnosed using morphology; however, it is not suitable for finding monosomy X and tetraploidy.
Röckelein
G
G
Pathological-Anatomical Institute, University of Erlangen-Nürnberg, F.R.G.
Ulmer
R
R
Schröder
J
J
D000022:Abortion, Spontaneous / Q000235:genetics*; D000704:Analysis of Variance; D002824:Chorionic Villi / Q000473:pathology*; D002869:Chromosome Aberrations / Q000235:genetics; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000473:pathology