title: Follicular dendritic cells in Hodgkin's disease.
abstract: The distribution of follicular dendritic cells (FDCs) was studied in 66 lymph nodes affected by Hodgkin's disease (HD) from as many patients with the use of the monoclonal antibody Ki-FDC1P, which stains FDCs in paraffin sections. Two distinct FDC patterns were distinguishable in the neoplastic areas: pattern A, showing FDC networks occupied by nongerminal center cells, often expanded and disrupted; and pattern B, with FDCs rare or lacking. Pattern A, with follicle-occupying cells represented by epithelioid and lymphocytic and histiocytic (L and H) cells, was found in about 90% of the cases of nodular lymphocyte predominance type and in about half of the cases of nodular sclerosis type, with the follicle-occupying cells being lacunar cells. In the group of mixed cellularity type, approximately one-fifth of the cases exhibited pattern A and in these cases the follicle-occupying cells were Sternberg-Reed, Hodgkin's, and epithelioid cells. The presence of follicular structures, although abnormal, is a more common occurrence in HD than is appreciable with the use of conventional histologic methods.
authors.affiliation: Department of Pathology, University of Kiel, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alavaikko
authors.forename: M L
authors.initials: ML
authors.lastname: Hansmann
authors.forename: C
authors.initials: C
authors.lastname: Nebendahl
authors.forename: M R
authors.initials: MR
authors.lastname: Parwaresch
authors.forename: K
authors.initials: K
authors.lastname: Lennert
mesh_terms: D000911:Antibodies, Monoclonal; D003713:Dendritic Cells / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006689:Hodgkin Disease / Q000145:classification / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal