title: The significance of the assays of urinary enzymes activity in patients with systemic lupus erythematosus.
abstract: The hyperexcretion of urinary enzymes with systemic Lupus Erythematosus (SLE) was assayed. 31 patients with confirmed SLE (30 women, and 1 man, age 16-33 years) were studied. Patients were divided into two groups according to the degree of kidney damage: 21 patients with proteinuria, and 10 patients without proteinuria. 12 patients of the first group had nephrotic syndrome (NS). 30 practically healthy subjects served as a control group. In patients with Lupus-nephritis (LN) the increase of activities of urinary GGT, AP, BGRS, NAG, and CHE was observed, the increase was especially clearly shown in LN-patients with NS. The increase of activity of urinary GGT and NAG was shown in the group of SLE patients who did not have clinical and laboratory signs of LN, which can be used as early index for the damage of tubular epithelium.
authors.affiliation: First Moscow Medical Institute I.M. Sechenov, USSR.
authors.forename: L
authors.initials: L
authors.lastname: Delektorskaya
authors.forename: T
authors.initials: T
authors.lastname: Janushkevich
authors.forename: D
authors.initials: D
authors.lastname: Okunev
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000652:urine; D002802:Cholinesterases / Q000652:urine; D005260:Female; D005966:Glucuronidase / Q000652:urine; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008180:Lupus Erythematosus, Systemic / Q000652:urine*; D008181:Lupus Nephritis / Q000652:urine*; D008297:Male; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D005966:Glucuronidase; D000118:Acetylglucosaminidase