The prevalence of beta-lactamase producing bacteria in subgingival plaque and their sensitivity to Augmentin.
Subgingival plaque samples from 20 patients with chronic periodontitis who had received no antibiotics for at least 3 months were screened for the presence of beta-lactamase-producing bacteria. Thirteen of the patients harboured beta-lactamase producing bacteria, most of which were members of the genus Bacteroides. The most frequently isolated species were Bacteroides melaninogenicus and Bacteroides capillosus which are often implicated in acute oral infections. All of the beta-lactamase-producing bacteroides strains were sensitive to a combination of amoxycillin with clavulanic acid (Augmentin).
Legg
J A
JA
Institute of Dental Surgery, London.
Wilson
M
M
D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology*; D019980:Amoxicillin-Potassium Clavulanate Combination; D001407:Bacillus / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D001439:Bacteroides / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D002908:Chronic Disease; D002969:Clavulanic Acids / Q000494:pharmacology*; D003773:Dental Plaque / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010403:Penicillin Resistance; D010518:Periodontitis / Q000382:microbiology*; D001443:Prevotella melaninogenica / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D001618:beta-Lactamases / Q000096:biosynthesis*
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D001618:beta-Lactamases