The effects of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin E.
The effects of fish oils supplemented with 0.3 IU/g and 1.5 IU/g of vitamin E were compared in a double-blind, cross-over study. Twelve healthy volunteers were given 30 mL/day of either oil for 3 wk. Intake of the vitamin E-rich fish oil resulted in a marked decrease in serum triglycerides (48%) and in fibrinogen (11%). After administration of the low vitamin E-containing oil there was a considerably smaller reduction of serum triglycerides and no significant reduction of fibrinogen. Both oils caused an increase in high density lipoprotein cholesterol and a decrease in the atherogenic index, but neither oil altered the total cholesterol level. Serum vitamin E was decreased by 9% and plasma malondialdehyde was increased by 122% after intake of the low vitamin E-containing oil, but both remained normal after intake of the other oil. The effect of vitamin E may be due to inhibition of fatty acid peroxidation with less formation of malondialdehyde and a larger amount of active (n-3) fatty acids in their sites of action in the liver, resulting in a greater decrease in the synthesis of triglycerides and fibrinogen.
Haglund
O
O
Department of Forensic Medicine, University of Uppsala, Sweden.
Luostarinen
R
R
Wallin
R
R
Wibell
L
L
Saldeen
T
T
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005395:Fish Oils / Q000008:administration & dosage*; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010545:Peroxides / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D005395:Fish Oils; D006595:Hexosamines; D007328:Insulin; D008055:Lipids; D010545:Peroxides; D014280:Triglycerides; D014810:Vitamin E; D019270:Fructosamine; D008315:Malondialdehyde; D005340:Fibrinogen; D002784:Cholesterol