The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals.
Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoate, 120 to 160 mg/d orally, on the parameters of the pulsatile secretion of LH in a group of six eugonadal female-to-male transsexuals with normal menstrual cycles. The treatment suppressed menstrual activity in all patients. Serum T and estrone were significantly elevated after treatment with oral T undecanoate. The parameters of the pulsatile secretion of LH were not affected by androgen administration. Levels of FSH, estradiol, and progesterone also did not change significantly.
Scheele
F
F
Department of Gynecology and Obstetrics, Academic Hospital of the Free University, Amsterdam, The Netherlands.
Hompes
P G
PG
Gooren
L J
LJ
Spijkstra
J J
JJ
Spinder
T
T
D004970:Estrone / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D011673:Pulsatile Flow; D011863:Radioimmunoassay; D013739:Testosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D014189:Transsexualism / Q000378:metabolism*
D004970:Estrone; D013739:Testosterone; D007986:Luteinizing Hormone; C010792:testosterone undecanoate