Studies of Cs retention in the human body related to body parameters and Prussian blue administration.
Using the in-vivo monitoring data from the individuals that suffered internal contamination in the Goiânia accident, a preliminary study on the elimination of Cs from their body was conducted. It was concluded that elimination follows a first-order linear kinetic pattern, both with and without Prussian Blue treatment. Cesium half-lives for both sexes were shown to be influenced mainly by the weight of each individual. In general, Prussian Blue seems to reduce the half-life by 32%. At the time our study was conducted, patients who were under treatment with the drug were receiving 3 g d-1, 6 g d-1, or 10 g d-1 of the medication. Our results suggest that there is an optimum dosage for a certain weight range to achieve this reduction in half-life, but one would need more data to statistically prove this assumption.
Lipsztein
J L
JL
Instituto de Radioproteção e Dosimetria/CNEN, Rio de Janeiro, Brazil.
Bertelli
L
L
Oliveira
C A
CA
Dantas
B M
BM
D000059:Accidents; D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D001822:Body Burden; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001938:Brazil; D002588:Cesium Radioisotopes / Q000493:pharmacokinetics*; D002648:Child; D003666:Decontamination / Q000379:methods*; D004781:Environmental Exposure; D005260:Female; D005295:Ferrocyanides / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D011867:Radioisotope Teletherapy / Q000295:instrumentation
D002588:Cesium Radioisotopes; D005295:Ferrocyanides; C000170:ferric ferrocyanide