Diversity of staphylococci exhibiting high-level resistance to mupirocin.
Plasmids mediating high-level resistance to mupirocin (MIC greater than 1000 mg/L) in staphylococci from various sources were studied by restriction endonuclease cleavage. Several patterns were obtained but six plasmids isolated from various Staphylococcus aureus and S. epidermidis strains were indistinguishable. The diversity and spread of these plasmids is illustrated.
Rahman
M
M
Institute of Dermatology, United Medical School, St. Thomas Hospital, London.
Connolly
S
S
Noble
W C
WC
Cookson
B
B
Phillips
I
I
D003030:Coagulase / Q000032:analysis; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004352:Drug Resistance, Microbial; D005227:Fatty Acids / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D016712:Mupirocin; D010957:Plasmids; D012150:Polymorphism, Restriction Fragment Length; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D003030:Coagulase; D004269:DNA, Bacterial; D005227:Fatty Acids; D016712:Mupirocin