Hypersensitivity of delayed type in hypertensive patients.
The agarose migration technique was used for demonstration of delayed-type hypersensitivity to arterial vessel wall antigens in patients suffering from chronic essential hypertension. By means of this technique, it was demonstrated that the migration indices from the hypertensive patients differed significantly from the normotensive control persons, P less than 0.005. The significant difference was abolished when anti-LIF was added to the migration tests. This means that a hypersensitivity of the delayed type had developed in the hypertensive patients and the results indicated that the hypersensitivity was an autoimmunity to arterial vessel wall antigens.
Olsen
F
F
Institute of Hygiene, University of Copenhagen, Denmark.
D000328:Adult; D000818:Animals; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D006973:Hypertension / Q000276:immunology*; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D007961:Leukocyte Migration-Inhibitory Factors