Influence of nocloprost on the vascular responses to various stimuli in the isolated perfused rabbit kidney.
Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism.
Ercan
Z S
ZS
Department of Pharmacology, Faculty of Medicine, Gazi University, Turkey.
Türker
R
R
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D014665:Vasodilator Agents; D000804:Angiotensin II; D010656:Phenylephrine; C048895:nocloprost; D009638:Norepinephrine