Bupivacaine kinetics in serum, cardiac and brain tissues: effect of diazepam pretreatment in mice.
This study was designed to document possible changes in bupivacaine kinetics in serum and in heart and brain tissues induced by a pretreatment with diazepam in mice. When diazepam is associated with bupivacaine, elimination of bupivacaine from serum and cardiac tissues is decreased; statistical differences were not found in brain tissues.
Bruguerolle
B
B
Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille.
Merland
V
V
Prat
M
M
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002045:Bupivacaine / Q000097:blood / Q000493:pharmacokinetics*; D003975:Diazepam / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism*
D003975:Diazepam; D002045:Bupivacaine