title: Marked plasmacytosis and immunoglobulin abnormalities following infusion of streptokinase.
abstract: Marked plasmacytosis is an uncommon clinical finding associated with plasma cell dyscrasias and certain reactive states, particularly serum sickness. Moreover, serum sickness-like reactions are a well-recognized complication of therapy with streptokinase. In this report, the authors describe a patient who developed a transient, but striking, plasmacytosis and an unexplained fever following streptokinase treatment for a pulmonary embolus. An evaluation for multiple myeloma was completely negative except for the occurrence of serum monoclonal-like proteins which largely disappeared over an eight month period.
authors.affiliation: Department of Medicine, VA Medical Center, Nashville, Tennessee 37213.
authors.forename: L
authors.initials: L
authors.lastname: Gorden
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: S E
authors.initials: SE
authors.lastname: Graber
mesh_terms: D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000139:chemically induced*; D012713:Serum Sickness / Q000139:chemically induced; D013300:Streptokinase / Q000009:adverse effects*
chemical_list: D007136:Immunoglobulins; D013300:Streptokinase