[Changes in hormone and neurotransmitter action with aging].
The paper is concerned with the mechanisms underlying an interaction between hormones and neurotransmitters and the specific receptors of glandular and nervous tissues during aging. The heterogeneous++ pattern of age changes in different receptors and in different tissues in described. Most prevalent are the phenomena of the reduced number of receptors but not their affinity, and at the postreceptor level--the deranged capacity of calcium mobilization. The possibility of correction of age changes in hormonal and neurotransmitter actions, both at the receptor and postreceptor level, is stressed.
Rot Dzh
Gerontological Research Center, National Institute on Aging, Baltimore.
D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D010306:Parotid Gland / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology
D006728:Hormones; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D002118:Calcium; D004298:Dopamine