Effect of dibutyltin dilaurate on regional brain polyamines in rats.
Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.
Khaliq
M A
MA
Industrial Toxicology Research Center, Lucknow, India.
Husain
R
R
Seth
P K
PK
Srivastava
S P
SP
D000818:Animals; D000871:Anthelmintics / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism*
D000871:Anthelmintics; D009947:Organotin Compounds; D013096:Spermine; C010409:dibutyltin dilaurate; D013095:Spermidine