Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats.
K(+)-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 microM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 microM) or the beta-adrenoceptor antagonist propranolol (1 microM). The mechanism underlying the relaxant effects of benzodiazepines on K(+)-contracted uterine rings is still under study.
Kazanietz
M G
MG
Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, UBA, Buenos Aires, Argentina.
Elgoyhen
A B
AB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D003292:Convulsants; D004967:Estrogens; D007546:Isoquinolines; C028513:4'-chlorodiazepam; D005442:Flumazenil; D004958:Estradiol; D002998:Clonazepam; D011189:Potassium Chloride; C010452:estradiol-17 beta-benzoate; D011433:Propranolol; D003975:Diazepam; D001640:Bicuculline; C037850:PK 11195