Gastrin- and somatostatin-immunoreactive cells of the antral mucosa in patients with duodenal or gastric ulcers. An immunocytochemical study.
Gastrin- and somatostatin-immunoreactive cells in biopsies taken from the prepyloric portion of the antrum from 15 patients with duodenal ulcer, 16 patients with gastric ulcer, and a control group of 19 patients without histopathological alterations of the antral mucosa were studied using peroxidase anti-peroxidase and immunogold-silver staining methods in combination with morphometry. Numerical densities and sizes (immunoreactive areas) of the cells demonstrated were measured and compared between all three groups. Gastrin- and somatostatin-immunoreactive cells were located most frequently in the lower midzone of the gastric crypts. None of the parameters measured showed a correlation with age or sex. The group with duodenal ulcer tended to exhibit gastrin- and somatostatin-cell-hyperplasia whereas the size of both cell types remained unchanged. In comparison with the control group, the numerical density of gastrin-immunoreactive cells was significantly increased in gastric ulcer patients, whereas the numerical density of somatostatin-immunoreactive cells was decreased in this group. Immunoreactive areas of both cell types were significantly increased in patients with gastric ulcer.
Hacker
G W
GW
Institute of Pathological Anatomy, Landeskrankenanstalten Salzburg, Austria.
Bernatzky
G
G
Graf
A H
AH
Hölbling
N
N
Stilianu
L
L
Payreder
M H
MH
Miller
K
K
Thurner
J
J
Adam
H
H
D000328:Adult; D000368:Aged; D002452:Cell Count; D004381:Duodenal Ulcer / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005755:Gastrins / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011706:Pyloric Antrum / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D013004:Somatostatin / Q000276:immunology*; D013276:Stomach Ulcer / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D005755:Gastrins; D013004:Somatostatin