Activation of glucose transport by activatory receptor agonists of adenylate cyclase in rat adipocytes.
1. Catecholamine, glucagon, and adrenocorticotropic hormone stimulated 2-deoxyglucose (2-DG) uptake via an increase in glucose transporters in plasma membranes, similarly to insulin. 2. In contrast to the action of insulin, the stimulating effects of these agonists on 2-DG uptake were abolished when Gi was not activated. 3. The mode of the 2-DG uptake stimulation was partially different among these agonists.
Shirakura
S
S
Department of Physioligical Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Furugohri
T
T
Tokumitsu
Y
Y
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active; D002772:Cholera Toxin / Q000494:pharmacology; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D004837:Epinephrine / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*
D007328:Insulin; D009004:Monosaccharide Transport Proteins; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D002772:Cholera Toxin; D003847:Deoxyglucose; D000262:Adenylyl Cyclases; D004837:Epinephrine