Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
8-OH-DPAT (2.5-10 mg/kg) and buspirone (10 mg/kg) but not 5,7-DHT (200 micrograms/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1-100 micrograms/kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.
Lecci
A
A
A Menarini Pharmaceuticals, Pharmacological Research Department, Firenze, Italy.
Borsini
F
F
Mancinelli
A
A
D'Aranno
V
V
Stasi
M A
MA
Volterra
G
G
Meli
A
A
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002065:Buspirone / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005334:Fever / Q000209:etiology* / Q000517:prevention & control; D005442:Flumazenil / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D017294:Ondansetron; D010879:Piperazines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D016713:Ritanserin; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D004873:Ergolines; D007093:Imidazoles; D010879:Piperazines; D010880:Piperidines; D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D016713:Ritanserin; C018406:1-(3-trifluoromethylphenyl)piperazine; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D005442:Flumazenil; D017294:Ondansetron; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C032663:LY 53857; D003975:Diazepam; D010134:Fenclonine; C015068:1-(3-chlorophenyl)piperazine; D002065:Buspirone