[Anti-somatostatin autoantibodies in the blood serum of patients with schizophrenia].
Solid-phase IEA was used to measure the level of autoantibodies to somatostatin in the blood serum of 44 schizophrenics and 24 healthy donors. The patients suffering from schizophrenia manifested a higher (p less than 0.01) level of immune responsiveness of the blood serum to somatostatin (0.665 +/- 0.03) as compared to the control group (0.509 +/- 0.05). The main contribution to the differences between the groups as regards the parameter measured is made by patients with malignant (0.810 +/- 0.10) and paranoid (0.773 +/- 0.08) schizophrenia whereas the patients' subgroup with slow-progressive schizophrenia did not differ from normal regarding the level of autoantibodies to somatostatin in the serum (0.504 +/- 0.03). These tentative data agree with a hypothesis of the involvement of autoimmune processes into the development of schizophrenia.
Rogaeva
E A
EA
Chumakova
M M
MM
Dergunova
N N
NN
Pozharitskaia
D A
DA
Kopeĭko
G I
GI
Tsutsul'kovskaia
M Ia
MIa
Tsibezov
V V
VV
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D012559:Schizophrenia / Q000209:etiology / Q000276:immunology*; D012563:Schizophrenia, Paranoid / Q000209:etiology / Q000276:immunology; D013004:Somatostatin / Q000276:immunology*
D001323:Autoantibodies; D013004:Somatostatin