title: Loss of heterozygosity of markers on chromosome 11 in tumors from patients with multiple endocrine neoplasia syndrome type 1.
abstract: Multiple endocrine neoplasia type 1 is an autosomal dominant condition characterized by the development of parathyroid hyperplasia, pituitary adenomas, and pancreatic islet cell tumors. Recently the gene for multiple endocrine neoplasia type 1 was mapped to the long arm of chromosome 11 between the loci PGA and INT2. We tested the hypothesis that tumor development is the result of a somatic deletion that unmasks a constitutional mutation. By investigating DNA isolated from tumors and somatic tissues in 12 patients from 4 different families with multiple endocrine neoplasia type 1, we found loss of heterozygous markers mapped to 11q13 in 9 (82%) of 11 informative tumors. In contrast, we were unable to identify allelic loss from other chromosomes using a variety of informative probes. This high incidence of chromosomal deletion of 11q13 suggests that this region is important in the oncogenesis of this disorder.
authors.affiliation: Department of Surgery, St. Louis University School of Medicine, Missouri.
authors.forename: D M
authors.initials: DM
authors.lastname: Radford
authors.forename: S W
authors.initials: SW
authors.lastname: Ashley
authors.forename: S A
authors.initials: SA
authors.lastname: Wells
authors.forename: D S
authors.initials: DS
authors.lastname: Gerhard
mesh_terms: D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D006579:Heterozygote; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*