Cyclosporine for the treatment of granulocytopenia in Felty's syndrome.
A patient with Felty's syndrome was treated with cyclosporine, initially 10 mg/kg/day and then 4 mg/kg/day. The neutrophil count increased by 6 weeks and was normal at 3 months. Over the subsequent 27 months the neutrophil count was closely related to the cyclosporine dosage and there was no evidence of cyclosporine toxicity. This case indicates that cyclosporine may have a role in the treatment of Felty's syndrome.
Canvin
J M
JM
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Dalal
B I
BI
Baragar
F
F
Johnston
J B
JB
D000380:Agranulocytosis / Q000188:drug therapy* / Q000209:etiology; D002452:Cell Count / Q000187:drug effects; D003524:Cyclosporins / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005258:Felty Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects
D003524:Cyclosporins