Elevated levels of CD4 antigen in sera of human immunodeficiency virus-infected populations.
CD4 antigen levels in sera from asymptomatic intravenous drug users and homosexuals and patients with lymphadenopathy, acquired immunodeficiency syndrome-related complex, or acquired immunodeficiency syndrome were quantitated. Like soluble CD8, CD4 antigen levels were elevated in human immunodeficiency virus-seronegative asymptomatic intravenous drug users and homosexuals, probably reflecting infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis B virus infections. The sera from human immunodeficiency virus-seropositive groups of patients with human immunodeficiency virus infection also had elevated levels of CD4 antigen, presumably reflecting infections like cytomegalovirus and human immunodeficiency virus infections.
Reddy
M M
MM
R. A. Cooke Institute of Allergy, St. Luke's Roosevelt Hospital Center, New York, New York 10019.
Vodian
M
M
Grieco
M H
MH
D000386:AIDS-Related Complex / Q000150:complications / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology; D006716:Homosexuality; D006801:Humans; D012995:Solubility; D015819:Substance Abuse, Intravenous; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens