title: Effects of dietary selenium and fish oil (MaxEPA) on arachidonic acid metabolism and hemostatic function in rats.
abstract: This study investigated whether hemostatic function can be modified by both the consumption of fish oil and the level of dietary selenium. Male Sprague-Dawley rats were fed for 8 wk semipurified diets containing 7% corn oil (by wt) or 5.5% fish oil (MaxEPA) plus 1.5% corn oil with or without selenium supplementation. Consumption of the four diets caused no difference in weight gain, food intake or plasma malondialdehyde content. The selenium-supplemented rats had significantly higher levels of selenium and glutathione peroxidase activity in plasma. Fish oil feeding decreased ADP-induced platelet aggregation and increased bleeding time. The level of dietary selenium and type of oil interacted to influence the production of 6-keto-prostaglandin F1 alpha: more was produced when corn oil was fed in the selenium-deficient diets. These data suggest that the effect of dietary selenium on hemostatic function and the production of eicosanoids is minor.
authors.affiliation: Department of Nutrition and Food Management, Oregon State University, Corvallis 97331.
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.forename: R C
authors.initials: RC
authors.lastname: Wander
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage*; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000008:administration & dosage* / Q000494:pharmacology; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D001095:Arachidonic Acids; D004041:Dietary Fats; D005395:Fish Oils; D008055:Lipids; D008315:Malondialdehyde; D013929:Thromboxane B2; D012643:Selenium