title: Isolation and sequence of partial cDNA clones of human L1: homology of human and rodent L1 in the cytoplasmic region.
abstract: We have isolated cDNA clones coding for the human homologue of the neuronal cell adhesion molecule L1. The nucleotide sequence of the cDNA clones and the deduced primary amino acid sequence of the carboxy terminal portion of the human L1 are homologous to the corresponding sequences of mouse L1 and rat NILE glycoprotein, with an especially high sequences identity in the cytoplasmic regions of the proteins. There is also protein sequence homology with the cytoplasmic region of the Drosophila cell adhesion molecule, neuroglian. The conservation of the cytoplasmic domain argues for an important functional role for this portion of the molecule.
authors.affiliation: La Jolla Cancer Research Foundation, California.
authors.forename: J R
authors.initials: JR
authors.lastname: Harper
authors.forename: J T
authors.initials: JT
authors.lastname: Prince
authors.forename: P A
authors.initials: PA
authors.lastname: Healy
authors.forename: J K
authors.initials: JK
authors.lastname: Stuart
authors.forename: S J
authors.initials: SJ
authors.lastname: Nauman
authors.forename: W B
authors.initials: WB
authors.lastname: Stallcup
mesh_terms: D000818:Animals; D001483:Base Sequence; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D003001:Cloning, Molecular; D003593:Cytoplasm / Q000502:physiology*; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D029721:Drosophila Proteins; D015723:Gene Library; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D039842:Neural Cell Adhesion Molecule L1; D051381:Rats; D012377:Rodentia / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D039842:Neural Cell Adhesion Molecule L1; C061745:Nrg protein, Drosophila; D004247:DNA