Toward an understanding of the schistosomicidal effect of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz).
In order to gain an interpretation of the schistosomicidal effect of 4-methyl 5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz), chemical, electrochemical and enzymatic hypotheses are discussed from a pharmacological standpoint. The enzymatic hypothesis is in good agreement with experimental results which ascertain that oltipraz behaves as a prodrug.
Fleury
M B
MB
Laboratoire de Chimie Analytique et Electrochimie, URA CNRS 1310, Faculté de Pharmacie, Paris, France.
Largeron
M
M
Martens
T
T
D000818:Animals; D004220:Disulfides / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors*; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D011355:Prodrugs / Q000494:pharmacology*; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012547:Schistosoma / Q000187:drug effects* / Q000201:enzymology; D012552:Schistosomiasis / Q000188:drug therapy; D013454:Sulfoxides / Q000097:blood / Q000378:metabolism; D013871:Thiones; D013876:Thiophenes
D004220:Disulfides; D011355:Prodrugs; D011719:Pyrazines; D013454:Sulfoxides; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz; D005980:Glutathione Reductase