Glutamine metabolism after small intestinal resection in humans.
Glutamine and leucine kinetics were measured using stable isotopes in five enterectomized patients (residual small bowel, 80 +/- 25 cm [mean +/- SE]) who were in a near normal nutritional status at distance from surgery. While parameters of leucine metabolism were normal, rates of whole body glutamine utilization were reduced by 20% in the patients. The data suggest that the small intestine plays a prominent role in glutamine utilization in vivo in humans.
Darmaun
D
D
INSERM u-290, Hôpital St. Lazare, Paris, France.
Messing
B
B
Just
B
B
Rongier
M
M
Desjeux
J F
JF
D000328:Adult; D005260:Female; D005973:Glutamine / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D007421:Intestine, Small / Q000502:physiology / Q000601:surgery*; D007700:Kinetics; D007930:Leucine / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status
D005973:Glutamine; D007930:Leucine