[Clinico-bacteriological studies on the etiology of bacterial prostatitis. II. Virulence factors of E. coli in bacterial prostatitis].
The virulence factors of E. coli in bacterial prostatitis were studied using 59 E. coli isolated from uncomplicated prostatitis. O-antigens of prostatitis-derived E. coli belonged to some specific serotypes such as 0-4, 6, 18, 22 and the haemolysin production was positive in 64.4%. With regard to the fimbriae, the majority of the strains had type 1 fimbriae (81.4%). Mannose resistant (MR) fimbriae were also positive in 59.3% and both type 1 and MR fimbriae were positive in 55.9%. Among MR strains, P-fimbriated and S-fimbriated strains were present in 25.7% and 28.6%, respectively, indicating that these two MR fimbriae were not always specific for the prostatitis-derived E. coli. Although the specific adhesion of E. coli onto the human prostatic epithelium mediated by MR-fimbriae was equivocal, that mediated by type 1 fimbriae was observed clearly. Therefore, type 1 fimbriae was thought to be one of the most significant virulence factors in the pathogenesis of prostatitis caused by E. coli.
Yamada
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Department of Urology, Okayama University Medical School.
D001422:Bacterial Adhesion; D004926:Escherichia coli / Q000145:classification / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections; D010861:Fimbriae, Bacterial; D006460:Hemolysin Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000382:microbiology*; D012703:Serotyping; D014774:Virulence
D006460:Hemolysin Proteins