Isolation of a growth and mitosis inhibitory peptide from mouse liver.
The isolation of a liver peptide that inhibits the growth, mitosis rate and thymidine incorporation in regenerating liver is described. The peptide has the structure Pyroglu-gln-gly-ser-asn, and the deamidated forms are also active. The peptide probably belongs to a class of growth inhibitors with a high degree of tissue specificity. Two such peptides have previously been isolated from the epidermis (Reichelt et al. 1987) and from colonic tissue (Skraastad et al. 1987).
Reichelt
K L
KL
Department of Pediatric Research, University of Oslo, Norway.
Paulsen
J E
JE
Elgjo
K
K
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000302:isolation & purification; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001681:Biological Assay; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D006131:Growth Inhibitors / Q000302:isolation & purification*; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000302:isolation & purification*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives
D000596:Amino Acids; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D009842:Oligopeptides; C067151:pyroglutamyl-glutaminyl-glycyl-seryl-asparagine; D011761:Pyrrolidonecarboxylic Acid