The in-situ absorption of antipyrine as a measure of intestinal blood flow in Fluosol-DA haemodiluted rats.
The effect of moderate Fluosol-DA haemodilution on intestinal blood flow has been investigated in the rat. Antipyrine in-situ intestinal absorption is blood flow limited, and did not alter 0.5, 24, 48, or 72 h after haemodilution with 40 mL kg-1 Fluosol. Thus the intestinal blood flow rate is maintained as part of the physiological response to ensure adequate perfusion of the vital organ.
Shrewsbury
R P
RP
School of Pharmacy, University of North Carolina, Chapel Hill 27599.
White
L G
LG
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D004338:Drug Combinations; D005466:Fluorocarbons / Q000494:pharmacology*; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives; D007408:Intestinal Absorption / Q000187:drug effects*; D007422:Intestines / Q000098:blood supply*; D008297:Male; D010952:Plasma Substitutes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D000983:Antipyrine