Molecular genetic aspects of glial tumour evolution.
Cancer can be viewed as a dynamic process driven by the cellular accumulation of genetic alterations that provide selective growth advantage. Such alterations can be classified as one of two fundamental types: acquired (cancer-affective, dominant) or eliminated (cancer suppressive, recessive). This review considers genetic alterations that occur during the development of the most common type of central nervous system tumour, glioma.
James
C D
CD
Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202.
Mikkelsen
T
T
Cavenee
W K
WK
Collins
V P
VP
D001932:Brain Neoplasms / Q000235:genetics*; D005784:Gene Amplification / Q000235:genetics; D005910:Glioma / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008967:Molecular Biology; D012150:Polymorphism, Restriction Fragment Length