[Expression of gamma-glutamyl transpeptidase related to the tumor differentiation on squamous cell carcinoma of human skin].
gamma-Glutamyl transpeptidase (gamma-GTP) has been noticed as one of the useful markers for malignant transformation of the skin. But the role and mechanism of the induction of gamma-GTP in skin carcinogenesis had not yet been studied. In this report, the authors studied the relationship between gamma-GTP activity and tumor differentiation in squamous cell carcinoma of human skin (SCC). Ten cases of SCC were examined on intensity and localization of the activity of gamma-GTP histochemically by the method of Rutenberg. gamma-GTP activity was found to be more intense in well differentiated SCC than in poorly differentiated SCC. On the other hand, localization pattern of gamma-GTP activity in SCC was not always related to the tumor grade. We concluded that expression of gamma-GTP activity in SCC may reflects the modulating cell differentiation rather than cell proliferation in malignant transformation of the skin. And some of the typical cases were presented.
Takami
Y
Y
Dermatological Department, Sapporo Medical College.
Chiba
M
M
Takahashi
M
M
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D005723:gamma-Glutamyltransferase