1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells.
Intraluminal injection of female rats at Day 5 of pseudopregnancy with 10-500 ng 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) significantly increased the uterine weight and induced decidual reaction. This effect was observed as early as the 3rd day after 1,25-(OH)2D3 injection. It was detectable only in the injected left horn and not in the non-injected right horn. A 500 ng dose of 25-(OH)D3 had no such effect. The present in-vivo results suggest that 1,25-(OH)2D3 may play a physiological role in endometrial cell differentiation into decidual cells, a crucial step in the process of blastocyst implantation.
Halhali
A
A
CNRS URA 583-Université Paris V, Hôpital des Enfants Malades, Paris, France.
Acker
G M
GM
Garabédian
M
M
D000818:Animals; D002112:Calcifediol / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology*; D003656:Decidua / Q000254:growth & development; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D011555:Pseudopregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000033:anatomy & histology
D002117:Calcitriol; D002112:Calcifediol