Long-term antimicrobial therapy in the prevention of recurrent soft-tissue infections.
Thirty-six patients who had suffered two or more episodes of erysipelas or cellulitis during the previous year were randomly divided into two equal groups; one group received erythromycin base 250 mg b.i.d. for 18 months, while the other group received no prophylaxis for a similar period. No patients in the treated group developed infection during the 18 months' follow-up but eight of the control group (50%) relapsed and required antibiotic treatment. Prolonged antimicrobial prophylaxis is effective and safe in preventing recurrent episodes of soft-tissue infections.
Kremer
M
M
Department of Dermatology, Zvulum Outpatient Clinic, Kyriat Motzkin, Israel.
Zuckerman
R
R
Avraham
Z
Z
Raz
R
R
D002481:Cellulitis / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004886:Erysipelas / Q000517:prevention & control*; D004917:Erythromycin / Q000627:therapeutic use*; D006801:Humans; D012008:Recurrence
D004917:Erythromycin