[Flumazenil (Anexate): an antagonist of benzodiazepines. Its pharmacopsychologic significance and role in traffic medicine].
Flumazenil (Anexate) reverses promptly the hypnotic effects of all known benzodiazepines. From the point of view of traffic medicine the question is of interest whether side effects after application of flumazenil can be seen and must be taken in account. Our investigations were concerned in answering this question. 20 mg flumazenil or placebo was administered in a randomized doubleblind crossover fashion. The following psychometric tests were employed: Befindlichkeitsskalen von Zersen (Bf-S), State-Trait-Inventory (STAI), Hamilton Anxiety Scale (HAMA) und visual analogue scales (VAS). In addition, subjective condition was inquired. Pharmacokinetics were investigated by a radio-receptor-assay. Flumazenil leads to an increase of negative sensations in respect to an invers agonizing effect. Lack of concentration and dizziness were reported by the probationer.
Zimmer
G
G
Institut für Rechtsmedizin, Universität Heidelberg.
Joachim
H
H
D000328:Adult; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors*; D001143:Arousal / Q000187:drug effects*; D001334:Automobile Driving / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010555:Personality Inventory; D011963:Receptors, GABA-A / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D005442:Flumazenil