Imaging of a parapharyngeal hemangiopericytoma. Radioimmunoscintigraphy (SPECT) with indium-111-labeled anti-CEA antibody, and comparison to digital subtraction angiography, computed tomography, and immunohistochemistry.
A 27-year-old male patient with a parapharyngeal hemangiopericytoma was investigated radiologically with orthopantomography, computed tomography, and digital subtraction angiography before the operation. Because a malignancy was suspected, the patient was imaged with gamma camera using radiolabeled monoclonal anticarcinoembryonal antigen antibody including single photon emission computed tomography. The radioantibody accumulated strongly into the neoplasm. Tumor to background ratio was 2.2. Samples of the excised tumor were stained immunohistochemically for desmin, vimentin, muscle actin, cytokeratin, CEA (carcinoembryonic antigen), and factor VIII. They showed that the antibody uptake was of unspecific nature and not due to CEA expression in the tumor.
Kairemo
K J
KJ
Division of Nuclear Medicine, Central Laboratory, Helsinki University Central Hospital, Finland.
Hopsu
E V
EV
Melartin
E J
EJ
Heikkilä
P S
PS
D000328:Adult; D015901:Angiography, Digital Subtraction; D000906:Antibodies; D002272:Carcinoembryonic Antigen / Q000276:immunology; D006393:Hemangiopericytoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007205:Indium Radioisotopes; D008297:Male; D010610:Pharyngeal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods
D000906:Antibodies; D002272:Carcinoembryonic Antigen; D007205:Indium Radioisotopes