title: CSF neuropeptide Y in alcoholics and normal controls.
abstract: Neuropeptide Y is found in brain tissue. In dogs it has been shown to enhance activation of the hypothalamic-pituitary-adrenal axis by corticotropin-releasing hormone. It is localized in certain catecholamine neurons and to some extent colocalized with somatostatin. Disturbances of the central noradrenergic system may underlie some forms of alcoholism. Therefore, we compared male alcoholics and normal controls on cerebrospinal fluid (CSF) levels of neuropeptide Y. There was no significant difference between the two groups for neuropeptide Y. There was also no significant difference for CSF levels of growth hormone releasing hormone. However, there were significant positive correlations between CSF levels of neuropeptide Y and CSF levels of corticotropin-releasing hormone, somatostatin, and growth hormone releasing hormone.
authors.affiliation: Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: W
authors.initials: W
authors.lastname: Berrettini
authors.forename: J
authors.initials: J
authors.lastname: DeJong
authors.forename: B
authors.initials: B
authors.lastname: Adinoff
authors.forename: B
authors.initials: B
authors.lastname: Ravitz
authors.forename: M
authors.initials: M
authors.lastname: Linnoila
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000134:cerebrospinal fluid*; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D005715:Gambling / Q000523:psychology; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid*; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D011863:Radioimmunoassay; D013004:Somatostatin / Q000134:cerebrospinal fluid
chemical_list: D009478:Neuropeptide Y; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine