Beta-globin gene haplotypes in Polynesians are predominantly southern Chinese in type.
beta-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical HindIII restriction fragment length polymorphism detected with pRK29, a 3' beta-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the beta-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in origin.
Trent
R J
RJ
Molecular Biology Laboratory, University of Sydney, NSW, Australia.
Ferguson
V
V
Hertzberg
M S
MS
Rutherford
J
J
Mickleson
K N
KN
D002880:Chromosomes, Human, Pair 11; D003241:Consanguinity; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D014905:Independent State of Samoa; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D005914:Globins