Increased proliferation of phytohaemagglutinin (PHA)-stimulated human leucocytes after 8-methoxypsoralen treatment.
The effect of 8-methoxypsoralen on human blood mononuclear cells cultured in darkness has been examined. 8-Methoxypsoralen (1 microgram mL-1, 4.6 microM) added to (phytohaemagglutinin-stimulated cells induced a two-fold increase in the number of mitoses. The number of blastic cells also increased. There was no effect on the formation of micronuclei and there was no chromosomal breakage.
Gawron
A
A
Department of Cell Biology, M. Curie-Skłodowska University, Lublin, Poland.
Górski
G
G
Głowniak
K
K
D002455:Cell Division / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects*; D008730:Methoxsalen / Q000494:pharmacology*; D015162:Micronucleus Tests; D008938:Mitosis / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology*
D010835:Phytohemagglutinins; D008730:Methoxsalen