Adamantane as a brain-directed drug carrier for poorly absorbed drug: antinociceptive effects of [D-Ala2]Leu-enkephalin derivatives conjugated with the 1-adamantane moiety.
Tsuzuki
N
N
Teikoku Seiyaku Co., Ltd., Kagawa, Japan.
Hama
T
T
Hibi
T
T
Konishi
R
R
Futaki
S
S
Kitagawa
K
K
D000218:Adamantane / Q000008:administration & dosage*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D004337:Drug Carriers; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D012995:Solubility
D000700:Analgesics; D004337:Drug Carriers; D004743:Enkephalin, Leucine; D000218:Adamantane