[An analysis of the distribution by molecular weight of an aggregate of biologically active compounds taking into account their possible penetration through gap-junction channels].
Analysis of molecular weight distribution of most well-known biologically active compounds demonstrates that all known types of bioregulatory compounds, excluding most peptides, have molecular mass less than 800 Da, i.e. they may penetrate the gap junction channels and, hence, play a part of intratissue regulators. Possible consequences of the analysis performed for understanding the role of neurohumoral regulation in phylogenesis and ontogenesis of multicellular eukaryotes have been discussed.
Gudoshnikov
V I
VI
Fedotov
V P
VP
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D007365:Intercellular Junctions / Q000378:metabolism*; D008970:Molecular Weight; D018377:Neurotransmitter Agents / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D010539:Permeability
D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D010455:Peptides