title: Gastric lymphoma causing granulocytopenia and cold intolerance, with recovery after treatment.
abstract: A 34-year-old man was found to have granulocytopenia with a white blood count of 2.3 x 10(9) l-1, consisting of 10% segmented neutrophils, 50% monocytes and 40% lymphocytes. A bone marrow aspirate showed 20% promyelocytes and 10% blasts with monoblastic features, and a smouldering myelomonocytic leukaemia was considered to be a possible diagnosis. In cold weather the patient experienced cold intolerance with acrocyanosis and small ulcerations on the ears. The test for heparin-precipitable protein ('cryofibrinogen') was strongly positive. During the following year, these signs and symptoms persisted, and the patient also developed constant moderate pain in the epigastric region. Gastroscopy revealed a large lymphoma of the stomach, which was a high-grade malignant centroblastic type of non-Hodgkin's lymphoma. After successful removal of the tumour, and six courses of potent cytostatic combinations, the patient recovered completely, and the granulocytopenia and cold intolerance disappeared.
authors.affiliation: Medical Department A, Rikshospitalet, Oslo, Norway.
authors.forename: P
authors.initials: P
authors.lastname: Stavem
authors.forename: T
authors.initials: T
authors.lastname: Rørvik
authors.forename: P
authors.initials: P
authors.lastname: Brandtzaeg
authors.forename: F
authors.initials: F
authors.lastname: Brosstad
authors.forename: R
authors.initials: R
authors.lastname: Nordhagen
authors.forename: P
authors.initials: P
authors.lastname: Grabner
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000209:etiology*; D003131:Combined Modality Therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000628:therapy; D008297:Male; D011928:Raynaud Disease / Q000209:etiology*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000150:complications* / Q000628:therapy