title: Occurrence of high-grade T-cell lymphoma in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia with breakpoint cluster region rearrangement: case report and review of the literature.
abstract: In this report, we describe a patient with Philadelphia chromosome-negative chronic myelogenous leukemia (CML) with breakpoint cluster region gene rearrangement who developed T-cell lymphoblastic lymphoma. The occurrence of T-cell lymphoblastic lymphoma coincided with the appearance in the bone marrow of the cytogenetic abnormality, trisomy 22q11.2----22qter. This is the first report of high-grade T-cell lymphoma in a patient with documented CML.
authors.affiliation: James Graham Brown Cancer Center, Department of Medicine, University of Louisville, Kentucky 40292.
authors.forename: B
authors.initials: B
authors.lastname: Djulbegović
authors.forename: T
authors.initials: T
authors.lastname: Hadley
authors.forename: F
authors.initials: F
authors.lastname: Yen
mesh_terms: D000328:Adult; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D005810:Multigene Family; D009378:Neoplasms, Multiple Primary; D010677:Philadelphia Chromosome