Prolonged neuromuscular blockade with vecuronium in a neonate with renal failure.
An 11-day-old neonate with renal failure caused by dysplastic kidneys was anaesthetised with thiopentone, vecuronium, nitrous oxide and oxygen, for insertion of a long-term peritoneal dialysis catheter. Complete neuromuscular block of 210 minutes' duration ensued after the initial dose of vecuronium (97 micrograms/kg). Partial block persisted for a further 30 minutes. The prolonged neuromuscular block in this case may have been because of proportionately greater dependence on renal clearance of vecuronium in neonates.
Haynes
S R
SR
Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.
Morton
N S
NS
D000768:Anesthesia, General; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D007676:Kidney Failure, Chronic / Q000601:surgery*; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D010530:Peritoneal Dialysis; D013997:Time Factors; D014673:Vecuronium Bromide / Q000009:adverse effects*
D014673:Vecuronium Bromide