title: Endophthalmitis from contaminated donor corneas following penetrating keratoplasty.
abstract: We encountered six (0.2%) cases of endophthalmitis resulting from contaminated donor corneas between January 1983 and July 1990 following a total of 3000 consecutive penetrating keratoplasties. Causative organisms in the three cases of fungal endophthalmitis were Torulopsis glabrata, Candida albicans, and Aspergillus flavus; the three cases of bacterial endophthalmitis were due to Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis. All organisms were resistant to gentamicin in the preservation media. A significantly higher incidence of endophthalmitis was noted in patients receiving corneas from a Sri Lankan eye bank (1.25%) than in those receiving US eye bank tissue (0.14%). Donor rim cultures are important to identify those patients at increased risk of developing endophthalmitis, enabling earlier diagnosis and more specific treatment should endophthalmitis occur.
authors.affiliation: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: J A
authors.initials: JA
authors.lastname: Cameron
authors.forename: S R
authors.initials: SR
authors.lastname: Antonios
authors.forename: J B
authors.initials: JB
authors.lastname: Cotter
authors.forename: N R
authors.initials: NR
authors.lastname: Habash
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000187:drug effects; D003315:Cornea / Q000382:microbiology; D004352:Drug Resistance, Microbial; D009877:Endophthalmitis / Q000209:etiology* / Q000473:pathology; D005125:Eye Banks; D015818:Eye Infections, Bacterial / Q000209:etiology* / Q000473:pathology; D015821:Eye Infections, Fungal / Q000209:etiology* / Q000473:pathology; D005260:Female; D005658:Fungi / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D005839:Gentamicins