Common intragenic and extragenic polymorphisms of blood coagulation factors VIII and IX are different in Chinese and Caucasian populations.
In order to examine the possibilities of carrier detection and prenatal diagnosis in hemophilia A and B in the Chinese region of Suzhou, we analyzed four different RFLPs within the factor IX gene and two intragenic RFLPs and one extragenic RFLP for the factor VIII gene. The results obtained show important differences between the Chinese and Caucasian populations. No polymorphism was found within the factor IX gene in the Chinese population and the informativity obtained for the factor VIII gene was quite different between the two populations for each RFLP studied.
de la Salle
C
C
INSERM U.311, Centre Régional de Transfusion Sanguine, Strasbourg, France.
Wu
Q
Q
Baas
M J
MJ
Hanauer
A
A
Ruan
C
C
Cazenave
J P
JP
D000328:Adult; D000483:Alleles; D002681:China; D015342:DNA Probes; D005164:Factor IX / Q000235:genetics*; D005169:Factor VIII / Q000235:genetics*; D005260:Female; D005602:France; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D005828:Genetics, Population; D006467:Hemophilia A / Q000175:diagnosis / Q000235:genetics*; D002836:Hemophilia B / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011296:Prenatal Diagnosis
D015342:DNA Probes; D005169:Factor VIII; D005164:Factor IX