title: The importance of multiple endocrine neoplasia syndromes in differential diagnosis.
abstract: In the differential diagnosis of endocrine symptoms, the autosomal dominant multiple endocrine neoplasia (MEN) syndromes are rare but important. We found seven index cases of MEN-I in 176 patients with adenomas of the anterior pituitary and 26 patients with primary hyperparathyroidism. Of 23 cases of medullary thyroid carcinoma and eight cases of pheochromocytoma, 14 patients are classified as MEN-IIa and one as MEN-IIb. Family screening identified six MEN-I and seven MEN-II cases among 32 individuals examined. Because of autosomal dominant inheritance and sometimes-delayed manifestation of the complete syndrome, screening of healthy and affected family members should be repeated at least every other year.
authors.affiliation: II. Medizinische Klinik, Klinikum Mannheim, Universität Heidelberg.
authors.forename: L
authors.initials: L
authors.lastname: Schaaf
authors.forename: M
authors.initials: M
authors.lastname: Greschner
authors.forename: W
authors.initials: W
authors.lastname: Geissler
authors.forename: B
authors.initials: B
authors.lastname: Eckert
authors.forename: F J
authors.initials: FJ
authors.lastname: Seif
authors.forename: K H
authors.initials: KH
authors.lastname: Usadel
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D010282:Parathyroid Neoplasms / Q000175:diagnosis; D010375:Pedigree; D010673:Pheochromocytoma / Q000175:diagnosis; D013964:Thyroid Neoplasms / Q000175:diagnosis