title: Successful use of gamete intrafallopian transfer does not reverse the decline in fertility in women over 40 years of age.
abstract: To assess the impact of assisted reproductive technologies on the potential fertility of older women, we report our experience with gamete intrafallopian transfer (GIFT) in a large number of women 40 years of age and older. One hundred twenty-two GIFT cycles were initiated in 59 women over 18 months. Seventy-three tubal transfers were performed, resulting in seven clinical pregnancies, a rate of 9.6% per transfer. This contrasts with a 27.3% clinical pregnancy rate per transfer in women under 40. Thus, older patients require thorough counseling regarding the decreased likelihood of success despite the use of assisted reproductive technologies.
authors.affiliation: Boston IVF, Brookline, Massachusetts.
authors.forename: A S
authors.initials: AS
authors.lastname: Penzias
authors.forename: I E
authors.initials: IE
authors.lastname: Thompson
authors.forename: M M
authors.initials: MM
authors.lastname: Alper
authors.forename: S P
authors.initials: SP
authors.lastname: Oskowitz
authors.forename: M J
authors.initials: MJ
authors.lastname: Berger
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008875:Middle Aged; D011247:Pregnancy