[Immunostimulating effect of D2 dopamine receptor agonist quinpirole].
Immunostimulating activity of specific postsynaptic D2 receptor agonist quinpirole (Ly 171555) was studied in CBA mice. The drug was administered intraperitoneally in a dose of 1 mg/kg 30 min before the immunization with SRBC (5 x 10(8)). Considerable stimulation of rosette- and plaque-forming cell number was observed at the early stage (3-d day) and at more late stage of the immune response (5-th day). The increase of rosette- and plaque-forming cell number was provided by IgM-reaction enhancement.
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D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects* / Q000276:immunology; D002452:Cell Count / Q000187:drug effects; D015259:Dopamine Agents; D004873:Ergolines / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D015259:Dopamine Agents; D004873:Ergolines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D019257:Quinpirole