[THe selective effect of neuroleptics on a dopamine-dependent behavioral disorder in rats in the extrapolation escape test].
The low doses of neuroleptics restored the ability of 1-DOPA treated rats to escape behaviour from acute stress situation (in the extrapolation escape test). Non-antipsychotic benzamides and phenothiazine, antidepressants and benzodiazepine tranquilizers were inactive. On the whole, the effectiveness of neuroleptics was in accordance with clinical data. The loss of ability to escape in 1-DOPA treated rats was accompanied by stereotypes hyperlocomotion in the water. Various psychotropic drugs decreased only hyperactivity without the influence on escape behaviour. Both forms of behavioral pathology were prevented by central aromatic acid decarboxylase inhibitor. However, the loss of ability to escape behavior only is selective and sensitive to neuroleptics action.
Bondarenko
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D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004924:Escape Reaction / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D007980:Levodopa; D004298:Dopamine