Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system.
We analyzed CSF from patients with multiple sclerosis, patients with other neurologic diseases, and healthy controls for the presence of prostaglandin (PG) E2, F2 alpha, D2, I, A, and leukotriene (LT) C4. Control CSF had little measurable PGs or LTs. CSF eicosanoids from patients with progressive MS were increased. We found PGD2 only in MS CSF. CSF monocytes from patients in active disease produced significantly increased PGD, PGE, and LTC4 than paired peripheral blood monocytes and monocytes from healthy controls. We saw no significant difference in LTC4 production between MS and control peripheral blood monocytes.
Dore-Duffy
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Wayne State University Multiple Sclerosis Clinical Research Center, Wayne State University School of Medicine, Detroit, MI 48201.
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Donovan
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D000938:Antigen-Presenting Cells / Q000378:metabolism* / Q000502:physiology; D002465:Cell Movement; D002490:Central Nervous System / Q000473:pathology*; D015777:Eicosanoids / Q000134:cerebrospinal fluid*; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D015230:Prostaglandin D2 / Q000096:biosynthesis*; D011453:Prostaglandins / Q000134:cerebrospinal fluid; D012016:Reference Values; D013189:SRS-A / Q000096:biosynthesis*
D015777:Eicosanoids; D011453:Prostaglandins; D013189:SRS-A; D015230:Prostaglandin D2