title: Protection of human health from mixtures of radionuclides and chemical in drinking water.
abstract: This study was undertaken to develop a common scale for evaluating health risks from contaminated drinking water. For different agents, many unrealistic models of risk have been used. By intent, regulatory toxicology depends on "data-sparse, model-intensive" analogies from exotic animal genetics and novel exposures (NCRP 1989). The question is, does a risk evaluation so derived have any predictive validity? Absence of data prevents answer because regulatory toxicology rationalizes in step-by-step logic, which we call absolute (i.e., predicts cases of disease in a population). Absolute models ensure safety, but do so at the cost of realism. In contrast, we make relative comparisons in the manner of horsepower or RBE from radiation biology. All pollutants are assumed to contribute to toxic injury. Next, relative potencies are linked to the most credible standards. Thus, experience is transferred from well-studied chemicals to the new chemical by "data-intensive, model-sparse" methods. This logos provides much relative precision. Then, pollutants are compared with: (1) common foodstuffs, (2) ambient radiation background, or (3) utility-pure drinking water. Finally, an assessment is made for a waste disposal area.
authors.affiliation: Health and Safety Research Division, Oak Ridge National Laboratory, Tennessee 37831-6101.
authors.forename: T D
authors.initials: TD
authors.lastname: Jones
authors.forename: B A
authors.initials: BA
authors.lastname: Owen
authors.forename: J R
authors.initials: JR
authors.lastname: Trabalka
mesh_terms: D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006262:Health; D006801:Humans; D012306:Risk; D012449:Safety; D014874:Water Pollutants, Chemical / Q000506:poisoning*; D014875:Water Pollutants, Radioactive / Q000506:poisoning*; D014881:Water Supply / Q000706:statistics & numerical data*
chemical_list: D002273:Carcinogens; D014874:Water Pollutants, Chemical; D014875:Water Pollutants, Radioactive