[Cyclosporin (CyA) and H2 antagonists].
An experimental study on rats in order to discovery any possible interaction between Ciclosporin (CyA) and H2-receptor antagonists has been carried out. The results obtained demonstrated that the serum levels of CyA were higher in rats treated with CyA and Cimetidine or Ranitidine, but not Famotidine. It is probable that the increase of ciclosporinaemia is the consequence of an increased hepatotoxicity due to administration of Cya in association with Cimetidine or Ranitidine.
Filingeri
V
V
Clinica Chirurgica, II Università degli Studi di Roma.
Rosati
R
R
Iacona
A
A
Giacomelli
R
R
Famularo
G
G
Calogero
A
A
Cervelli
V
V
Tonietti
G
G
Casciani
C U
CU
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003524:Cyclosporins / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D015738:Famotidine / Q000494:pharmacology; D005234:Fatty Liver / Q000139:chemically induced / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003524:Cyclosporins; D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine