title: Recovery from disturbed colonic transit time after alcohol withdrawal.
abstract: The effects of alcohol withdrawal on total and segmental transit time were evaluated in 20 chronic alcoholic subjects. After withdrawal, colorectal transit time significantly increased from 24.9 +/- 3.6 to 33.3 +/- 4.5 hours mean +/- SE (P less than 0.01). This was the result of an exclusive increase in rectosigmoid transit time from 2.8 +/- 0.7 to 9.8 +/- 2.1 hours (P less than 0.001). No variations were found in right or left colon transit time. Distal colonic motility is thus a crucial factor in the genesis of diarrhea in chronic alcoholic subjects.
authors.affiliation: Departement de Physiologie, Hôpital Laennec, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Bouchoucha
authors.forename: B
authors.initials: B
authors.lastname: Nalpas
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: P H
authors.initials: PH
authors.lastname: Cugnenc
authors.forename: J P
authors.initials: JP
authors.lastname: Barbier
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003106:Colon / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003967:Diarrhea / Q000209:etiology; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors