Changes in extracellular glutamate concentration after acute subdural haematoma in the rat--evidence for an "excitotoxic" mechanism?
Using a rat model of subdural haematoma which is associated with ischaemic damage in the ipsilateral hemisphere, we have measured cerebral blood flow and release of excitatory amino acids after the haematoma. A more than sevenfold rise in glutamate and aspartate, persisting for forty minutes occurred in the severely ischaemic cortex (CBF less than 5 ml 100 gm-1 min-1) and a threefold, sustained rise was seen in hippocampus, although CBF was preserved (85 ml/100 g/-1 min-1). Excitotoxic mechanisms may, therefore, be involved in the ischaemic damage associated with subdural haematoma.
Bullock
R
R
University Department of Neurosurgery, Southern General Hospital, Glasgow, Scotland.
Butcher
S
S
McCulloch
J
J
D000208:Acute Disease; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002560:Cerebrovascular Circulation; D003956:Dialysis / Q000379:methods; D005110:Extracellular Space / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006408:Hematoma, Subdural / Q000378:metabolism*; D009498:Neurotoxins / Q000502:physiology; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D005971:Glutamates; D009498:Neurotoxins; D018698:Glutamic Acid