[Individual human personality characteristics as a factor in the etiology of postvaccinal reactions].
Healthy volunteers with quite opposite emotional properties defined by means of Cattell Personality Questionnaires were shown to have essential differences in their postvaccinal reactions. These differences were seemingly caused by psychoemotional tension developing in unstable persons as a result of their perception of vaccination as a threatening factor. The administration of Phenasepam (3 mg) decreased such emotional tension and thus removed negative reactions at the postvaccinal period. The preparation had no influence on the production of protective antibodies to all types of antigens used for immunization.
Gapochko
K G
KG
Kudrin
I D
ID
Sambukova
T V
TV
Savel'ev
A P
AP
D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D004644:Emotions / Q000187:drug effects; D006801:Humans; D007114:Immunization / Q000009:adverse effects / Q000379:methods / Q000523:psychology; D007206:Individuality; D007277:Injections, Jet; D008297:Male; D010551:Personality / Q000187:drug effects; D010931:Plague Vaccine / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D014611:Vaccination / Q000009:adverse effects / Q000523:psychology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D022121:Cholera Vaccines; D010931:Plague Vaccine; D014436:Typhoid-Paratyphoid Vaccines; D001569:Benzodiazepines; C017928:phenazepam