title: Nonsurgical treatment of Histoplasma endocarditis involving a bioprosthetic valve.
abstract: Endocardial involvement associated with disseminated histoplasmosis has been infrequently documented, especially among patients with prosthetic valves. The therapeutic approach to these patients is also not yet clearly defined. A 54-year-old man with prosthetic valve endocarditis due to histoplasmosis was successfully treated with amphotericin B. A review of the literature suggests that the optimal form of therapy is likely a combination of surgical replacement of the involved valve and high dose amphotericin B. Successful therapy with amphotericin B alone may, however, be achieved if surgery is not a viable option.
authors.affiliation: Department of Medicine, Queen's University, Kingston, Ontario, Canada.
authors.forename: D S
authors.initials: DS
authors.lastname: Kanawaty
authors.forename: M J
authors.initials: MJ
authors.lastname: Stalker
authors.forename: P W
authors.initials: PW
authors.lastname: Munt
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D001705:Bioprosthesis; D004696:Endocarditis / Q000188:drug therapy / Q000382:microbiology*; D006350:Heart Valve Prosthesis; D006660:Histoplasmosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve
chemical_list: D000666:Amphotericin B