title: The maternal-effect gene fsh is essential for the specification of the central region of the Drosophila embryo.
abstract: The maternal-effect gene, female sterile (1) homeotic (fsh), has been implicated in the determination of segmental organization and identity. We have analyzed the spatial patterns of expression of several segmentation and homeotic genes in fsh-deficient embryos. We observed perturbations in the expression of the Ultrabithorax gene in parasegments 6, 7, and 8, consistent with the domain in which homeotic transformations occur in adults derived from such embryos. Further, the expression of the gap gene Krüppel and the pair-rule gene even-skipped is altered, especially in the central region of the embryo. Our results suggest that the defects in segmental organization in fsh-deficient progeny are mediated primarily but not exclusively through a restriction of the domain of Krüppel expression.
authors.affiliation: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
authors.forename: D H
authors.initials: DH
authors.lastname: Huang
authors.forename: I B
authors.initials: IB
authors.lastname: Dawid
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005801:Genes, Homeobox; D005804:Genes, Lethal; D009154:Mutation