title: Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia.
abstract: Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1.
authors.affiliation: Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
authors.forename: T F
authors.initials: TF
authors.lastname: Schulz
authors.forename: D
authors.initials: D
authors.lastname: Whitby
authors.forename: J G
authors.initials: JG
authors.lastname: Hoad
authors.forename: T
authors.initials: T
authors.lastname: Corrah
authors.forename: H
authors.initials: H
authors.lastname: Whittle
authors.forename: R A
authors.initials: RA
authors.lastname: Weiss
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D006800:Deltaretrovirus Infections / Q000382:microbiology; D005260:Female; D005714:Gambia; D005814:Genes, Viral; D014644:Genetic Variation; D015498:HIV-2 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D012689:Sequence Homology, Nucleic Acid; D014779:Virus Replication