Cardiac sympathetic tone in anaesthetized diabetics.
To assess cardiac sympathetic nervous function in diabetics, the heart rates attained following a pharmacological dose of intravenous atropine, 23 micrograms.kg-1, were studied under N2O, isoflurane anaesthesia in diabetics (n = 21) and nondiabetics (n = 30). Atropine-induced heart rate in diabetics was significantly lower than that in nondiabetics (95 +/- 14 (SD) bpm vs 109 +/- 12 bpm, P less than 0.001) and were closely related to preoperative orthostatic diastolic blood pressure change (r = 0.60, P less than 0.01). There was some correlation between the atropine-induced heart rate and preoperative RR-variation in diabetics (r = 0.50, P less than 0.05). The findings suggest that cardiac sympathetic function may also be impaired in diabetics with orthostatic hypotension.
Tsueda
K
K
Department of Anesthesiology, University of Louisville, Kentucky 40292.
Huang
K C
KC
Dumont
S W
SW
Wieman
T J
TJ
Thomas
M H
MH
Heine
M F
MF
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001285:Atropine / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011187:Posture; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology
D001285:Atropine