title: Physico-chemical properties and stability of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate.
abstract: The physico-chemical properties of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate (Org 5222), a new potential antipsychotic compound, were studied by interpretation of its spectra (UV,IR,NMR,mass), X-ray analysis, thermal properties, solubilities and partition coefficient. Analytical methods such as GLC and TLC were developed for use in stability tests. Crystalline Org 5222 was shown to be stable with respect to heat. Only excessive exposure to light was shown to induce degradation of crystalline Org 5222. In solutions of pH 1, 4 and 7 only slight degradation was observed at high temperature or after exposure to light.
authors.affiliation: Scientific Development Group, Organon International B.V., Pharma Division Akzo, Oss, The Netherlands.
authors.forename: C W
authors.initials: CW
authors.lastname: Funke
authors.forename: H
authors.initials: H
authors.lastname: Hindriks
authors.forename: A P
authors.initials: AP
authors.lastname: Sam
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis*; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D003986:Dibenzocycloheptenes; D003990:Dibenzoxepins / Q000032:analysis*; D004355:Drug Stability; D006576:Heterocyclic Compounds, 4 or More Rings; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D003990:Dibenzoxepins; D006576:Heterocyclic Compounds, 4 or More Rings; C522667:asenapine