title: [Osteomalacia and renal tubular acidosis associated with analgesic abuse. A clinical case].
abstract: Osteomalacia is a multifactorial bone disorder. Main causes are vitamin D deficiency and phosphorus depletion. Among patients with renal insufficiency the incidence of osteomalacia is variable and probable related to impairment of the synthesis of 1,25 dihydroxy-vitamin D3 (calcitriol). We report a patients with severe osteomalacia, hyperkalemic tubular acidosis, low serum calcitriol levels and insufficiency associated to a prolonged overuse of analgesic drugs. Differential diagnosis and pathophysiology are discussed.
authors.affiliation: Departamentos de Nefrourología, Universidad Católica de Chile, Santiago.
authors.forename: A
authors.initials: A
authors.lastname: Valdivieso
authors.forename: F
authors.initials: F
authors.lastname: Flores
authors.forename: F
authors.initials: F
authors.lastname: Llach
authors.forename: A J
authors.initials: AJ
authors.lastname: Felsenfeld
authors.forename: L
authors.initials: L
authors.lastname: Massardo
authors.forename: S
authors.initials: S
authors.lastname: Jacobelli
mesh_terms: D000141:Acidosis, Renal Tubular / Q000175:diagnosis / Q000209:etiology*; D000701:Analgesics, Opioid; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007085:Ilium / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000175:diagnosis / Q000209:etiology*; D012651:Self Medication / Q000009:adverse effects; D019966:Substance-Related Disorders / Q000150:complications* / Q000175:diagnosis
chemical_list: D000701:Analgesics, Opioid