Endocytosis and antigen processing.
It has become increasingly clear that endocytosis plays a critical role in the processing of exogenous antigens for presentation to T lymphocytes. However, many critical questions remain concerning the pathways taken by antigens and MHC molecules following internalization by antigen presenting cells. This review summarizes current information concerning the general features and functions of the endocytic pathway in mammalian cells. We also identify the likely roles of the various endocytic organelles in each of the events associated with antigen processing.
Mellman
I
I
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
D000818:Animals; D000941:Antigens / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000276:immunology; D004705:Endocytosis / Q000276:immunology*; D011992:Endosomes / Q000276:immunology; D006801:Humans; D008247:Lysosomes / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D010873:Pinocytosis / Q000276:immunology
D000941:Antigens