Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.
We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.
Olschwang
S
S
Laboratoire de Génétique Moléculaire des Tumeurs, Institut Curie, Paris, France.
Laurent-Puig
P
P
Vassal
A
A
Salmon
R J
RJ
Thomas
G
G
D001483:Base Sequence; D003110:Colonic Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012004:Rectal Neoplasms / Q000235:genetics*; D012016:Reference Values; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D015345:Oligonucleotide Probes; D016159:Tumor Suppressor Protein p53