Effect of procaterol on arterial blood gas in asthmatic children.
We determined changes in arterial blood gas after the inhalation of procaterol, a highly beta 2-selective and long-acting adrenergic agonist, in 11 asthmatic children. Seven of the patients, with a maximum fall of 14 mmHg (63.6%), showed a decrease in PaO2 (mean +/- SD = -7.1 +/- 4.0 mmHg) and had poorer pulmonary function with a lower initial PaO2 than four subjects who had an increase in PaO2 after inhalation. There was a statistically significant correlation between values of the PaO2 before and after inhalation (P less than .05).
Obata
T
T
Tokyo Jikei University School of Medicine, Japan.
Masaki
T
T
Ilkura
Y
Y
D000280:Administration, Inhalation; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D010100:Oxygen / Q000097:blood*; D017265:Procaterol
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D010100:Oxygen; D017265:Procaterol