title: Body composition by bioelectrical-impedance analysis compared with deuterium dilution and skinfold anthropometry in patients with chronic obstructive pulmonary disease.
abstract: Body composition is an important measure of nutritional status in patients with chronic obstructive pulmonary disease (COPD). We generated a regression model for bioelectrical impedance (BI) by using deuterium dilution (2H2O) as a reference method in 32 COPD patients, aged 63 +/- 9 y (mean +/- SD), in stable pulmonary and cardiac condition. Height squared divided by resistance (Ht2/Res) correlated well with total body water (TBW) as measured by 2H2O (r = 0.93, P less than 0.001, SEE = 1.9 L). The best-fitting regression equation to predict TBW comprised Ht2/Res and body weight (r2 = 0.89, SEE = 1.8 L, P less than 0.001). BI-predicted TBW was used to estimate BI-fat-free mass (FFM) that was compared with skinfold-thickness-based FFM predictions (Anthr-FFM). Relative to BI-FFM a significant overestimation of 4.4 +/- 0.8 kg was found by Anthr-FFM. Our results suggest that BI is a useful measure of body composition in patients with severe COPD.
authors.affiliation: Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Schols
authors.forename: E F
authors.initials: EF
authors.lastname: Wouters
authors.forename: P B
authors.initials: PB
authors.lastname: Soeters
authors.forename: K R
authors.initials: KR
authors.lastname: Westerterp
mesh_terms: D000368:Aged; D000886:Anthropometry; D001823:Body Composition; D015992:Body Mass Index; D001834:Body Water / Q000378:metabolism; D003903:Deuterium; D004553:Electric Conductivity; D004594:Electrophysiology / Q000379:methods; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D011865:Radioisotope Dilution Technique; D012044:Regression Analysis; D012885:Skinfold Thickness
chemical_list: D003903:Deuterium