title: A preliminary study on the effects of atropine sulphate on bradycardia and heart blocks during romifidine sedation in the horse.
abstract: Romifidine (STH 2130-Cl or Sedivet) is an alpha 2-agonistic imino-imidazol sedative for intravenous use in horses recently developed by Boehringer Ingelheim, Vetmedica GmbH. An exploratory study was done in nine warm-blood horses, randomly divided into three groups, which received different dosages of romifidine (0.04, 0.08 and 0.12 mg/kg of body weight (BWT) intravenously (i.v.)) with at least one week's interval between tests. Romifidine induced a marked bradycardia accompanied by second degree atrioventricular (AV) block and some sinus blocks at all tested dosages. A placebo (NaCl 0.9% i.v.) given 5 min before and after romifidine did not affect the cardiac disturbances induced by romifidine. A low dose of atropine sulphate (0.005 mg/kg of BWT i.v.) given 5 min before romifidine counteracted the bradycardia and caused a normal to increased heart rhythm at all romifidine dosages. A higher dose of atropine sulphate (0.01 mg/kg of BWT i.v.) administered 5 min before sedation induced a tachycardia (average 70 beats/min) at all romifidine dosages and completely prevented the bradycardia and the heart blocks. The positive chronotrope effects of atropine sulphate were attenuated by increasing doses of romifidine. The effects of atropine sulphate (low or high doses) given 5 min after romifidine only appeared after 5 min. Both dosages counteracted the bradycardia and suppressed the heart blocks. No atropine-dependent side effects were observed in non-fasted horses. The degree of the romifidine induced sedation was not affected by the use of atropine sulphate given before or after romifidine.
authors.affiliation: Large Animal Surgical Clinic, Faculty of Veterinary Medicine, State University of Gent, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Gasthuys
authors.forename: D
authors.initials: D
authors.lastname: Parmentier
authors.forename: L
authors.initials: L
authors.lastname: Goossens
authors.forename: A
authors.initials: A
authors.lastname: De Moor
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000009:adverse effects*; D000818:Animals; D001285:Atropine / Q000627:therapeutic use*; D001919:Bradycardia / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006327:Heart Block / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D006339:Heart Rate / Q000187:drug effects; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007093:Imidazoles / Q000009:adverse effects*; D011897:Random Allocation
chemical_list: D000316:Adrenergic alpha-Agonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; D001285:Atropine; C076257:romifidine