Adrenergic dependence of the platelet aggregation in rats.
The paper examines the effect of different adrenergic agents influencing both the neuronal unit of the adrenergic transmitter system and its alpha- and beta-receptor components on the ADP-induced platelet aggregation. A considerable inhibition of the platelet aggregation is found under conditions of post-reserpine adrenergic block (16.06%, p less than 0.001) and blocking of the beta 1-adrenergic receptors with practolol, applied independently (45.06%, p less than 0.001) and prior to the treatment of the rats with dobutamine--beta 1-adrenoreceptor agonist (52.20%, p less than 0.001). The stimulation of these receptors with dobutamine accelerates the platelet aggregation by 41.04% (p less than 0.001). No changes in the platelet aggregation are found after treatment with phenoxybenzamine (nonselective alpha adrenergic blocker) and salbutamol (beta 2-adrenergic agonist). It may be concluded that the ADP-induced platelet aggregation depends to a certain extent on the functional state of the neuronal and beta-adrenoreceptor unit of the adrenergic transmitter system and possibly also on the metabolic processes connected with them.
Ganchev
T
T
Physiology Department, Higher Medical Institute, Varna.
Negrev
N
N
Ilkova
R
R
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D004280:Dobutamine / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation; D011217:Practolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D004280:Dobutamine; D000244:Adenosine Diphosphate; D012110:Reserpine; D000420:Albuterol; D011217:Practolol