Compatibility of cefoperazone sodium and cimetidine hydrochloride in 5% dextrose injection.
The compatibility of cimetidine hydrochloride and cefoperazone sodium in 5% dextrose injection stored at two temperatures was studied. Cimetidine hydrochloride and cefoperazone sodium were reconstituted or diluted with 5% dextrose injection to form an admixture with a cimetidine concentration of 2 mg/mL and a cefoperazone concentration of 5 mg/mL. The admixture was stored in 100-mL vented i.v. containers in the dark at 4 and 25 degrees C; three containers were stored at each temperature. A 2-mL sample was taken from each container after 0.5, 0.75, 1, 6, 12, 24, and 48 hours of storage and visually inspected, tested for pH, and assayed by a stability-indicating high-performance liquid chromatographic method. Triplicate studies were done for each storage condition. At both temperatures, drug concentrations varied by less than 5% during the study period. No color change, precipitation, or cloudiness was observed for any of the solutions under any of the storage conditions. Cefoperazone sodium 5.0 mg/mL and cimetidine hydrochloride 2.0 mg/mL in admixtures in 5% dextrose injection are stable for 48 hours at 4 and 25 degrees C.
Lee
D K
DK
Department of Pharmacy, Kaoshung Veterans General Hospital, Taipei, Taiwan, Republic of China.
Wang
D P
DP
Lee
A
A
D002438:Cefoperazone / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D005947:Glucose / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D013696:Temperature; D013997:Time Factors
D004338:Drug Combinations; D002438:Cefoperazone; D002927:Cimetidine; D005947:Glucose