Pharmacokinetics of antipsychotic drugs in man.
Variability in the outcome of treatment with antipsychotic drugs may be due to differences in compliance and to variations in pharmacokinetics and concentration-response relationships at the receptor level. Among the various chemical classes of neuroleptics, the butyrophenones, the phenothiazines, and the thioxanthenes have similar pharmacokinetics, and show larger inter-individual variations in plasma drug levels after oral than after intramuscular doses. Compared to the "classical" neuroleptics, the more water-soluble benzamide derivatives have significantly shorter elimination half-lives, and show smaller inter-patient variations in plasma level: dose ratios at steady state.
Dahl
S G
SG
Institute of Medical Biology, University of Tromsø School of Medicine, Norway.
D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D011618:Psychotic Disorders / Q000097:blood*; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2