title: Plasma somatostatin-like immunoreactivity during growth-hormone-releasing hormone therapy in non-growth-hormone-deficient children.
abstract: To date, the effects of long-term growth hormone (GH)-releasing hormone [GHRH(1-29)-NH2] treatment on the plasma concentrations of somatostatin-like immunoreactivity (SLI) remain undefined. In the present study, the effect of GHRH(1-29)-NH2 therapy on plasma SLI levels has been studied in 11 non-GH-deficient children. The pattern of administration was 5 micrograms/kg body weight, given subcutaneously once every day. There was no significant change in plasma SLI levels after bolus injection of GHRH(1-29)-NH2 before and during GHRH(1-29)-NH2 therapy. However, plasma SLI rose in basal plasma and nocturnal sleep after 3 months of GHRH(1-29)-NH2 therapy and remained the same during 6 months of treatment with GHRH(1-29)-NH2. The reason for this finding is uncertain, but an increase in SLI release from the enteroinsular axis is a possible explanation. The association of our findings with the role of the circulating SLI on nutrient homeostasis and the effects of GNRH on growth velocity is discussed.
authors.affiliation: Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Universidad de Alcalá de Henares, España.
authors.forename: E
authors.initials: E
authors.lastname: Arilla
authors.forename: J
authors.initials: J
authors.lastname: Fragoso
authors.forename: R
authors.initials: R
authors.lastname: Barrio
authors.forename: B
authors.initials: B
authors.lastname: Colás
authors.forename: S
authors.initials: S
authors.lastname: Donnay
authors.forename: B
authors.initials: B
authors.lastname: Roca
authors.forename: M
authors.initials: M
authors.lastname: Hernández
mesh_terms: D001827:Body Height / Q000187:drug effects; D002648:Child; D006130:Growth Disorders / Q000188:drug therapy*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood* / Q000276:immunology; D013997:Time Factors
chemical_list: D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone