Genetic activity profiles in the testing and evaluation of chemical mixtures.
Some knowledge of the potential genetic activity of a complex environmental mixture may be gained from an assessment of the genetic activity of its component chemicals. The expanded Genetic Activity Profile (GAP) data base provides a computer-generated graphic representation of genetic bioassay data as a function of dose of the substance tested. In addition, the Atmospheric Chemical Compound (ACC) data-base contains information on chemical structures, properties, detection methods, and sources of chemicals found in ambient air. Using the combined data bases, the quantity of an individual chemical present within a mixture or fraction of a mixture may be related to the quantity (lowest effective dose, LED) of the chemical, by itself, required to demonstrate a positive response in one or more genetic bioassays.
Waters
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Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Claxton
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Stack
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Brady
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Graedel
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D000818:Animals; D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental; D004247:DNA / Q000187:drug effects*; D006801:Humans; D007256:Information Systems; D009152:Mutagenicity Tests; D009153:Mutagens; D012907:Smoking / Q000009:adverse effects
D002274:Carcinogens, Environmental; D009153:Mutagens; D004247:DNA