GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland.
Chromaffin cell gamma-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.
Strong
R
R
Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, MO 63125.
Hale
C
C
Moore
M A
MA
Wessels-Reiker
M
M
Armbrecht
H J
HJ
Richardson
A
A
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011916:Rats, Inbred F344; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012110:Reserpine / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D012333:RNA, Messenger; D011963:Receptors, GABA-A; D012110:Reserpine; D014446:Tyrosine 3-Monooxygenase; D001640:Bicuculline