title: Pneumothorax in a patient with Wegener's granulomatosis during treatment with immunosuppressive agents.
abstract: We present the case of a 16-year-old woman with Wegener's granulomatosis, who developed a pneumothorax while receiving treatment with cyclophosphamide and glucocorticoids. The lung was re-expanded by tube drainage, and the patient recovered completely while the immunosuppressive treatment was continued in combination with sulphamethoxazole-trimethoprim. A possible role for this antimicrobial drug in the treatment of Wegener's granulomatosis is briefly discussed.
authors.affiliation: First Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: R
authors.initials: R
authors.lastname: Azemoto
authors.forename: Y
authors.initials: Y
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Ueda
authors.forename: M
authors.initials: M
authors.lastname: Wakashin
authors.forename: M
authors.initials: M
authors.lastname: Ohto
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D011030:Pneumothorax / Q000188:drug therapy / Q000209:etiology*; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D003520:Cyclophosphamide; D014295:Trimethoprim; D013420:Sulfamethoxazole