[A new substance with nootropic activity--N-5(hydroxynicotinoyl)-L-glutamic acid].
The psychopharmacological activity of a new compound--ONK-10--N-5(hydroxynicotinoyl)-L-glutamic acid was studied. It was shown in experiments on mice and rats that the compound possesses the pronounced antiamnestic and antihypoxic effects, does not disturb the conditioned reflex activity and the orientation behavior, has no anxiolytic activity and anticonvulsant properties, causes no disorder of movement coordination, is low toxic. ONK-10 is superior by its antiamnestic and antihypoxic effects to piracetam, meclophenoxat, demanol aceglumate and is not inferior to aniracetam.
Voronina
T A
TA
Garibova
T L
TL
Khromova
I V
IV
Kuznetsova
E A
EA
Smirnov
L D
LD
D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005971:Glutamates / Q000494:pharmacology* / Q000627:therapeutic use; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000494:pharmacology / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D014151:Anti-Anxiety Agents; D005971:Glutamates; D009125:Muscle Relaxants, Central; D009539:Nicotinic Acids; D011619:Psychotropic Drugs; C066295:nooglutil