title: Transport of organochlorine residues in the rat and human blood.
abstract: Organochlorine residues (OCR)2 are poorly soluble in water and are transported in the organism bound by the blood components. The distribution among blood fractions (cells/plasma, lipoproteins/rest of plasma proteins) were variable depending on the residue (HCB, p p'-DDE, HCH, Aroclor 1260, PCP) and on the species (rat, man). Differences were not found between in vivo (after oral single dosing) and in vitro (blood incubation) experiments. Results indicated a high affinity of organochlorine residues for lipoproteins; however, binding to blood carriers was very weak as demonstrated by the rapid release of residues by elution through a reverse phase column. The effects of residue binding to blood components on the distribution kinetics to tissues are discussed.
authors.affiliation: Unitat de Medicina Legal, Facultat de Medicina, Hospital Clinic i Provincial, Universitat de Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Catalán
authors.forename: J
authors.initials: J
authors.lastname: To-Figueras
authors.forename: M
authors.initials: M
authors.lastname: Rodamilans
authors.forename: J
authors.initials: J
authors.lastname: Corbella
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics*; D008074:Lipoproteins / Q000378:metabolism; D010573:Pesticide Residues / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D008074:Lipoproteins; D010573:Pesticide Residues