Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine.
Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.
Forrest
B D
BD
Department of Medicine, University of Adelaide, Australia.
LaBrooy
J T
JT
Robinson
P
P
Dearlove
C E
CE
Shearman
D J
DJ
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007422:Intestines / Q000276:immunology; D008297:Male; D011897:Random Allocation; D012137:Respiratory System / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated