title: Cimetidine and coumarin therapy of renal cell carcinoma. A pilot study.
abstract: Thirty-eight patients with metastatic renal-cell carcinoma (RCC) and 1 patient with a second primary RCC were treated with coumarin and cimetidine. Patients received 400 mg cimetidine p.o. daily and after 1 week 100 mg coumarin p.o. daily in addition until tumour progression. Two complete remission (30 and 50+ months) and 3 partial remissions (14, 13.8 months) could be achieved. Problems regarding possibly spontaneous regressions and comparable results of other treatment in RCC are discussed.
authors.affiliation: 5th Medical Department, Krankenhaus Lainz, Austria.
authors.forename: O
authors.initials: O
authors.lastname: Kokron
authors.forename: S
authors.initials: S
authors.lastname: Maca
authors.forename: G
authors.initials: G
authors.lastname: Gasser
authors.forename: P R
authors.initials: PR
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D002927:Cimetidine / Q000008:administration & dosage*; D003374:Coumarins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D003374:Coumarins; D002927:Cimetidine