title: Warning: fatal reaction to the use of fibrin glue in deep hepatic wounds. Case reports.
abstract: Two cases of severe hypotension following the use of fibrin glue for hemostasis in hepatic injuries are reported. A systemic reaction to bovine thrombin via large venous lacerations is suspected. A preliminary animal study supports this hypothesis. Caution is advised in the use of fibrin glue for hemostasis in deep hepatic wounds.
authors.affiliation: Department of Surgery, Denver General Hospital, CO 80204.
authors.forename: R
authors.initials: R
authors.lastname: Berguer
authors.forename: R L
authors.initials: RL
authors.lastname: Staerkel
authors.forename: E E
authors.initials: EE
authors.lastname: Moore
authors.forename: F A
authors.initials: FA
authors.lastname: Moore
authors.forename: W B
authors.initials: WB
authors.lastname: Galloway
authors.forename: M B
authors.initials: MB
authors.lastname: Mockus
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006489:Hemostatic Techniques; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007267:Injections; D008099:Liver / Q000293:injuries*; D008297:Male
chemical_list: D015718:Fibrin Tissue Adhesive