title: Regional cerebral blood flow during spreading cortical depression in conscious rats.
abstract: Spreading cortical depression (SCD) of EEG activity was induced in one cerebral hemisphere of conscious restrained rats by direct current stimulation of the lateral frontal cortex. Regional CBF was measured using [14C]iodoantipyrine and brain dissection. An early phase of increased CBF was not measured in conscious rats, but an early relative hyperperfusion was measured if the resting CBF was first reduced by treatment with pentobarbital or indomethacin. A long-lasting reduction in CBF was measured in conscious rats following the passage of SCD. This flow reduction resolved after 3 h. In conscious rats, CBF decreased in the striatum and thalamus ipsilateral to the SCD, paralleling the CBF changes occurring in the cortex. The CBF change in these deep structures was abolished by pentobarbital. An early transient increase in regional CBF was measured in the cerebral cortex contralateral to the hemisphere involved with SCD in conscious rats. This early contralateral hyperperfusion was also abolished by pentobarbital or indomethacin but not by atropine or propranolol. The vascular response to SCD in conscious rats differs from that which occurs in anesthetized rats.
authors.affiliation: Department of Medicine (Division of Neurology), Milton S. Hershey Medical Center, State University, Hershey.
authors.forename: R B
authors.initials: RB
authors.lastname: Duckrow
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003342:Corpus Striatum / Q000098:blood supply; D013181:Cortical Spreading Depression / Q000502:physiology*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000098:blood supply
chemical_list: D010424:Pentobarbital; D007213:Indomethacin