Chlorpromazine and clothiapine actions at the level of the CNS and vas deferens.
CNS-level changes caused by chlorpromazine and clothiapine, a structural analogue, were studied with a battery of behavioral tests in rats, along with the ability of these two drugs to antagonize electrically and alpha-stimulator (phenylephrine-)induced contractions in the rat vas deferens. The findings indicated that clothiapine, while less effective as an alpha-receptor antagonist, was a much more active CNS-depressant than chlorpromazine.
Pérez Raya
M D
MD
Department of Pharmacology, Faculty of Pharmacy, University of Granada, Spain.
Zarzuelo
A
A
Duarte
J M
JM
Jiménez
J
J
Navarro
C
C
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003987:Dibenzothiazepines / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects*
D003987:Dibenzothiazepines; D002746:Chlorpromazine