title: Significant increase of urinary mucoprotein in environmental-cadmium-exposed Japanese subjects.
abstract: Urinary mucoprotein (U-MP) was determined in 169 Japanese environmental-cadmium-exposed and 81 non-exposed subjects. Urinary total protein, albumin, beta 2-microglobulin (beta 2-MG), cadmium (Cd) and creatinine were also measured. Significant increases in U-MP and other proteins were found in the Cd-exposed subjects. Significant correlations between each protein were seen in the Cd-exposed and the total group of subjects. U-MP was highly correlated with urinary beta 2-MG and their correlation coefficient was the highest in the total group of subjects. beta 2-MG was the most sensitive indicator among them to detect Cd-induced renal dysfunction, although beta 2-MG is degraded in urine with a pH less than 5.5 U-MP is an acid-soluble protein. Therefore, U-MP is also available for studies on renal dysfunction caused by exposure to Cd, in conjunction with beta 2-MG.
authors.affiliation: Department of Hygiene and Public Health, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kido
authors.forename: R
authors.initials: R
authors.lastname: Honda
authors.forename: I
authors.initials: I
authors.lastname: Tsuritani
authors.forename: M
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Nogawa
mesh_terms: D000419:Albuminuria / Q000652:urine; D002104:Cadmium / Q000633:toxicity* / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007564:Japan; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D009088:Mucoproteins; D001613:beta 2-Microglobulin; D002104:Cadmium; D003404:Creatinine