title: [A case of aortoduodenal fistula following radiotherapy of retroperitoneal metastatic disease].
abstract: A new case of aortoduodenal fistula was added to the five cases previously reported in the literature, in which malignancy and/or its treatments could be implicated. This 67 year-old woman, six years previously had been placed on a therapy including irradiation on the pelvis for cancer of uterine cervix. For this time she underwent a radiotherapy completed in a total dose of 55.6 Gy combined with hyperthermia and chemotherapy for retroperitoneal metastatic disease with excellent response. Three months later she had hematemesis followed by melena and deteriorated to hemorrhagic shock. Emergent aortography detected contrast extravasation from the aorta with subsequent opacification of the duodenum, and immediate intraaortic balloon occlusion was done, but she died soon thereafter. Postmortem examination revealed the fistula from the aorta just above the bifurcation to a 2 by 1.5 cm. area of the posterior wall of the third portion of the duodenum. Accentuated arteriosclerosis in locally irradiated portion of the aorta, obstruction of small arteries from organized thrombus and hyaline necrosis in the wall of the fistulous tract were defined without evidence of tumor invasion. Based upon the findings of the patient reported herein, radiation might be another possible etiologic factor in aortoduodenal fistula, as well as tumor invasion per se.
authors.affiliation: Department of Obstetrics and Gynecology, Shizuoka Saiseikai General Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fukasawa
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Narushima
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Udagawa
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000209:etiology*; D003131:Combined Modality Therapy; D004378:Duodenal Diseases / Q000209:etiology*; D005260:Female; D005402:Fistula / Q000209:etiology*; D006801:Humans; D006979:Hyperthermia, Induced; D007412:Intestinal Fistula / Q000209:etiology*; D009361:Neoplasm Invasiveness; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology