Experimental treatment of L-801 myeloid leukemia mice with low molecular weight natural tumor suppressor of human fetal brain origin.
In human fetal brain tissue there is a low molecular weight suppressor substance which can preferentially suppress murine myeloid leukemic cell (L-801) growth, but with less harmful effects on the growth of normal bone marrow hemopoietic stem cells (CFU-S) and granuloid/macrophage progenitors (CFU-GM) in vitro liquid or agar culture. Mice after inoculation of L-801 cells died within 10-17 days due to development of leukemia. After consecutive injections of the low molecular weight suppressor substance isolated from human fetal brain tissue some of the leukemic mice survived. No pathological changes were observed in the mice which survived longer than 100 days after inoculation of L-801 cells.
Wei
Q S
QS
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
Wu
C T
CT
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001923:Brain Chemistry; D002478:Cells, Cultured; D005333:Fetus; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D051379:Mice; D008970:Molecular Weight; D014020:Tissue Extracts / Q000494:pharmacology
D000970:Antineoplastic Agents; D014020:Tissue Extracts