Effects of cysteamine administration on plasma concentration of metabolites, pancreatic glucagon and insulin in the chicken.
1. The effects of subcutaneous injection of cysteamine (2-mercaptoethylamine, 300 mg/kg) were investigated in 5-6 week-old chickens. 2. In the short term (1 hr), cysteamine increased plasma levels of glucose, free fatty acids and insulin, and decreased that of alpha-amino non protein nitrogen. 3. In a longer term (17-24 hr), cysteamine increased the plasma level of glucose, did not modify those of alpha-amino non protein nitrogen, insulin and glucagon and decreased that of free fatty acids. 4. The disposal of an oral glucose load was impaired and the glucose-induced inhibition of pancreatic glucagon and stimulation of insulin release were blunted 17 hr after cysteamine administration. 5. Therefore, cysteamine exerts multiple effects on chicken pancreatic islet cells.
Rideau
N
N
Station de Recherches Avicoles, INRA, Nouzilly, France.
Karmann
H
H
Simon
J
J
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D002645:Chickens / Q000378:metabolism*; D003543:Cysteamine / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood*; D005951:Glucose Tolerance Test; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D003543:Cysteamine; D005934:Glucagon