Free fatty acids do not influence the concentrations of free steroid hormones in serum under physiological conditions.
In several recent studies it has been suggested that FFA may influence the concentrations of unbound steroid hormones in serum, but the experimental design of these studies has been questioned. We have reexamined the effects of oleic acid on the unbound concentrations of several steroid hormones in serum, including cortisol, testosterone, and estradiol. The results demonstrate that under physiological conditions, oleic acid does not affect the unbound concentrations of these hormones when assays are carried out with whole serum.
Murai
J T
JT
Reproductive Endocrinology Center, University of California, San Francisco 94143.
Mendel
C M
CM
Siiteri
P K
PK
D004958:Estradiol / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*
D009829:Oleic Acids; D012709:Serum Albumin; D019301:Oleic Acid; D013739:Testosterone; D004958:Estradiol; D006854:Hydrocortisone