title: Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine.
abstract: Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.
authors.affiliation: Department of Medicine, University of Adelaide, Australia.
authors.forename: B D
authors.initials: BD
authors.lastname: Forrest
authors.forename: J T
authors.initials: JT
authors.lastname: LaBrooy
authors.forename: P
authors.initials: P
authors.lastname: Robinson
authors.forename: C E
authors.initials: CE
authors.lastname: Dearlove
authors.forename: D J
authors.initials: DJ
authors.lastname: Shearman
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007422:Intestines / Q000276:immunology; D008297:Male; D011897:Random Allocation; D012137:Respiratory System / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated