The effect of diabetes on the in vivo acetylation capacity of the spontaneously diabetic, insulin-dependent BB/Edinburgh Wistar rat.
In contrast to previous studies using chemically-induced diabetic rats, the in vivo acetylation of sulphamethazine is increased in spontaneously diabetic, insulin-dependent BB/Edinburgh (BB/E) Wistar rats compared to non-diabetic control animals from the same colony. In both diabetic and non-diabetic rats, male animals had a significantly higher acetylation capacity than female animals. The percentage recovery of the administered dose was significantly higher in urine samples from female rats.
Lindsay
R M
RM
University of Edinburgh, Department of Medicine, Western General Hospital, U.K.
Baird
J D
JD
D000107:Acetylation; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria; D006863:Hydrogen-Ion Concentration; D008297:Male; D011507:Proteinuria; D051381:Rats; D011913:Rats, Inbred BB / Q000378:metabolism*; D012737:Sex Factors; D013418:Sulfamethazine / Q000652:urine; D014554:Urination
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D013418:Sulfamethazine