Carcinogenic potency correlations: real or artifactual?
It has been suggested by various investigators that observed interspecies correlations of carcinogenic potency estimates based on bioassays are to a degree due to tautologous aspects of experimental designs. Some authors have even suggested that carcinogenic potency estimates derived from chronic bioassays are little more than experimental design artifacts. In this paper it is argued that constraints imposed by the use of the one-hit model to estimate carcinogenic potency are more restrictive than potential experimental design constraints.
Kodell
R L
RL
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Gaylor
D W
DW
Chen
J J
JJ
D000818:Animals; D015197:Carcinogenicity Tests / Q000706:statistics & numerical data*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats