Effects of remoxipride on psychomotor performance, alone and in combination with ethanol and diazepam.
The effects of remoxipride, alone and in combination with ethanol and diazepam, on sensory, cognitive, and neuromotor performance were studied in 12 healthy volunteers (7 men, 5 women). The study was of double-blind randomized, crossover design with each subject receiving six different single-dose experimental treatments at six sessions. Tests of sensory, cognitive, and neuromotor functions were carried out, together with subjective assessments. Remoxipride alone seemed to have no effect on the sensory functions measured, but it affected cognitive and neuromotor functions to a limited extent. In general the effects of ethanol and diazepam alone were more pronounced than those of remoxipride. When remoxipride was combined with either ethanol or diazepam, there was a tendency for the effect to be additive.
Mattila
M J
MJ
Department of Clinical Pharmacology, University of Helsinki, Finland.
Mattila
M E
ME
D000284:Administration, Oral; D000328:Adult; D000428:Alcohol Drinking / Q000097:blood; D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001549:Benzamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D003975:Diazepam / Q000493:pharmacokinetics / Q000494:pharmacology*; D004311:Double-Blind Method; D004357:Drug Synergism; D000431:Ethanol / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D017330:Remoxipride
D014150:Antipsychotic Agents; D001549:Benzamides; D017330:Remoxipride; D000431:Ethanol; D003975:Diazepam