title: Prognostic significance of valvular regurgitation in patients with infective endocarditis.
abstract: OBJECTIVE
  Doppler ultrasound is a sensitive modality for detecting and quantitating valvular regurgitation in patients with infective endocarditis. Because valvular regurgitation leads to heart failure, we evaluated the prognostic significance of Doppler-detected valvular regurgitation in patients with endocarditis who had not yet developed clinical heart failure.
  
  
  METHODS
  We reviewed the medical records of 65 patients with a clinical diagnosis of infective endocarditis from May 1985 to March 1990. A total of 49 patients were included in the study: 33 patients with native valve endocarditis and 16 patients with prosthetic valve endocarditis. The initial Doppler echocardiogram was examined in these patients to determine the presence and degree of valvular regurgitation.
  
  
  RESULTS
  Significant (moderate to severe) valvular regurgitation was detected in 23 (47%) patients. The presence or absence of significant valvular regurgitation did not predict the development of congestive heart failure, the need for surgery, or death (p = NS). The development of congestive heart failure was significantly associated with the need for surgery (p less than 0.0001) and death (p less than 0.05).
  
  
  CONCLUSIONS
  We conclude that the detection of significant valvular regurgitation in patients with infective endocarditis who have not yet developed heart failure is not predictive of future complications nor does the absence of significant valvular regurgitation identify a group of patients with a more favorable prognosis. In our series, patients who developed congestive heart failure had a significantly higher incidence of surgery and death. Therefore, decisions regarding clinical management in patients with infective endocarditis should not be made solely on the presence or absence of echocardiographically detected valvular regurgitation.
authors.affiliation: Department of Medicine, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102.
authors.forename: D G
authors.initials: DG
authors.lastname: Karalis
authors.forename: E A
authors.initials: EA
authors.lastname: Blumberg
authors.forename: J F
authors.initials: JF
authors.lastname: Vilaro
authors.forename: V A
authors.initials: VA
authors.lastname: Covalesky
authors.forename: J M
authors.initials: JM
authors.lastname: Wahl
authors.forename: K
authors.initials: K
authors.lastname: Chandrasekaran
authors.forename: G S
authors.initials: GS
authors.lastname: Mintz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015150:Echocardiography, Doppler; D004697:Endocarditis, Bacterial / Q000150:complications*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis