title: Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.
abstract: We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.
authors.affiliation: Laboratoire de Génétique Moléculaire des Tumeurs, Institut Curie, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Olschwang
authors.forename: P
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: A
authors.initials: A
authors.lastname: Vassal
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: G
authors.initials: G
authors.lastname: Thomas
mesh_terms: D001483:Base Sequence; D003110:Colonic Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012004:Rectal Neoplasms / Q000235:genetics*; D012016:Reference Values; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D015345:Oligonucleotide Probes; D016159:Tumor Suppressor Protein p53