title: Modification of pain on injection of propofol--a comparison between lignocaine and procaine.
abstract: Pain on injection of propofol was assessed in a controlled, randomised study of 273 patients. They received either lignocaine 10 mg, procaine 10 mg or isotonic saline 0.5 ml, 15 seconds before the injection of propofol into a vein on the back of the hand. The incidence of pain on injection in the control group (51%) was comparable with other studies. Lignocaine and procaine both significantly reduced the pain (35% and 34% respectively, p less than 0.05) but there was no statistical difference between these two groups.
authors.affiliation: Royal Marsden Hospital, London.
authors.forename: M E
authors.initials: ME
authors.lastname: Nicol
authors.forename: J
authors.initials: J
authors.lastname: Moriarty
authors.forename: J
authors.initials: J
authors.lastname: Edwards
authors.forename: D S
authors.initials: DS
authors.lastname: Robbie
authors.forename: R P
authors.initials: RP
authors.lastname: A'Hern
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000772:Anesthesia, Local; D006801:Humans; D008012:Lidocaine; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011184:Postoperative Period; D011343:Procaine; D015742:Propofol / Q000009:adverse effects*
chemical_list: D011343:Procaine; D008012:Lidocaine; D015742:Propofol