[Multiple endocrine neoplasms type I].
The patient had been treated ten years previously for acromegaly. At present he was in hypercalcaemic crisis owing to multiple hyperparathyroid adenomas. He had multiple small pancreatic glucagonomas and a malignant duodenal gastrinoma which led to recurrent episodes of duodenal and gastric ulcers with perforations and hemorrhages. The hypercalcaemia increased the hypergastrinaemia significantly and probably accelerated the ulcer diathesis. This patient illustrates well how severe and complicated the clinical situation can be in patients with MEN-1 and emphasizes the importance of being aware of the syndrome.
Andersen
H O
HO
Rigshospitalet, København, kirurgisk gastroenterologisk afdeling C.
Bardram
L
L
Moesgaard
F
F
D000328:Adult; D006801:Humans; D006934:Hypercalcemia; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy