Hepatocyte transplantation into the lung for treatment of acute hepatic failure in the rat.
The lung was investigated as a matrix for transplanted hepatocytes in the rat model. Surgically induced fulminant hepatic failure was successfully treated by injection of 5 to 7 x 10(7) isolated hepatocytes into the pulmonary parenchyma in 86% of the animals. No animal, however, survived injection of hepatocytes into the jugular vein. It was found that liver failure is a prerequisite for the intrapulmonary survival of hepatocytes. After regeneration of the native liver, the majority of hepatocytes are cleared away within 6 months.
Then
P
P
Department of Transplant Surgery, University Hospital, Innsbruck, Austria.
Sandbichler
P
P
Erhart
R
R
Dietze
O
O
Klima
G
G
Vogel
W
W
Margreiter
R
R
D000208:Acute Disease; D000818:Animals; D002469:Cell Separation / Q000379:methods; D006498:Hepatectomy; D008099:Liver / Q000166:cytology; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000502:physiology*; D008168:Lung; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic