Behavioral genetic analysis of regional mouse brain biogenic amines, acidic metabolites and motor activity.
1. Comparative analyses of regional brain biogenic amines and spontaneous locomotor activity of three mouse strains suggest a genotype dependent relationship. 2. A positive correlation between striatal dopamine and locomotor activity was determined in the inbred albino BALB/c mouse strain. 3. An inverse relationship between some brain regions serotonin and motility was found in the inbred black C57BL/6 mouse strain. 4. No correlation could be established between brain monoamines and motor activity in the hybrid CDF-1 mouse strain. 5. The results suggest that inbred BALB/c and C57BL/6 mouse strains may be useful animal models for studying dopaminergic and serotonergic acting agents, respectively.
Messiha
F S
FS
Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000235:genetics*; D013045:Species Specificity
D001679:Biogenic Amines