A molecular genetic linkage map of mouse chromosome 7.
The homology between mouse chromosome 7 and human chromosomes 11, 15, and 19 was examined using interspecific backcross animals derived from mating C3H/HeJ-gld/gld and Mus spretus mice. In an earlier study, we reported on the linkage relationships of 16 loci on mouse chromosome 7 and the homologous relationship between this chromosome and the myotonic dystrophy gene region on human chromosome 19. Segregation analyses were used to extend the gene linkage relationships on mouse chromosome 7 by an additional 21 loci. Seven of these genes (Cyp2a, D19F11S1h, Myod-1, Otf-2, Rnu1p70, Rnu2pa, and Xrcc-1) were previously unmapped in the mouse. Several potential mouse chromosome 7 genes (Mel, Hkr-1, Icam-1, Pvs) did not segregate with chromosome 7 markers, and provisional chromosomal assignments were made. This study establishes a detailed molecular genetic linkage map of mouse chromosome 7 that will be useful as a framework for determining linkage relationships of additional molecular markers and for identifying homologous disease genes in mice and humans.
Saunders
A M
AM
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Seldin
M F
MF
D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002888:Chromosomes, Human, Pair 19; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics; D009136:Muscular Dystrophies / Q000235:genetics; D009137:Muscular Dystrophy, Animal / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D005819:Genetic Markers