Modulation of antitumour drug resistance: experimental laboratory data and results of clinical evaluation.
Laboratory studies have provided a number of interesting leads relating to modulation of antitumour drug resistance. Several ideas have been evaluated clinically and phase I studies with certain newer agents are planned.
Hill
B T
BT
Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund Laboratories, London, UK.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D019328:Buthionine Sulfoximine; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D002955:Leucovorin / Q000494:pharmacology / Q000627:therapeutic use; D008562:Membrane Glycoproteins / Q000378:metabolism; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D004176:Dipyridamole; D014700:Verapamil; D005978:Glutathione; D002955:Leucovorin