Synergistic effects of INTERCEED(TC7) and heparin in reducing adhesion formation in the rabbit uterine horn model.
Surgical adjuvants are commonly employed to reduce the frequency of postoperative adhesion development after reproductive pelvic surgery. The ability of indomethacin, promethazine dexamethasone, Intralipid, progesterone, and heparin to reduce adhesion formation in combination with INTERCEED(TC7) (Johnson and Johnson Medical, Inc., New Brunswick, NJ), an absorbable barrier that alone reduces adhesion formation, was examined in a rabbit uterine horn model. A significant reduction in adhesion formation was only observed with the combination of INTERCEED(TC7) plus heparin. In addition studies, heparin delivery by intraperitoneal (IP) lavage, intravenous injection, or intra-abdominal instillation failed to demonstrate efficacy. Similarly, heparin delivery with other barriers or IP instillates (carboxymethylcellulose or 32% Dextran 70) failed to reduce adhesion formation. We conclude that INTERCEED(TC7) can be efficaciously utilized as a carrier to deliver heparin to traumatized surfaces, thereby reducing adhesion formation.
Diamond
M P
MP
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
Linsky
C B
CB
Cunningham
T
T
Kamp
L
L
Pines
E
E
DeCherney
A H
AH
diZerega
G S
GS
D000818:Animals; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D007213:Indomethacin / Q000494:pharmacology; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000473:pathology / Q000517:prevention & control; D014599:Uterus / Q000187:drug effects / Q000473:pathology / Q000601:surgery*
D002483:Cellulose, Oxidized; C060002:INTERCEED; D006493:Heparin; D007213:Indomethacin