title: Cytogenetic evidence of involvement of an early progenitor myeloid cell in 4;11 translocation-associated acute leukemia.
abstract: The t(4;11)(q21;q23)-associated acute leukemia may show both lymphoid and myelomonocytic features, which suggests a pluripotent progenitor stem cell as the hematopoietic cell involved in this neoplastic process. However, there is no cytogenetic evidence to support this contention. We present a case of acute myelomonocytic leukemia (M4, FAB subtype) with t(4;11)(q21;q23), which was also found in several hypertetraploid metaphases probably corresponding to megakaryocytes. This confirms the cellular origin in an early progenitor myeloid cell of this type of acute leukemia.
authors.affiliation: Unidad de Genética, Hospital La Fe, Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Palau
authors.forename: F
authors.initials: F
authors.lastname: Prieto
authors.forename: L
authors.initials: L
authors.lastname: Badia
authors.forename: M
authors.initials: M
authors.lastname: Beneyto
authors.forename: A
authors.initials: A
authors.lastname: Sempere
authors.forename: D
authors.initials: D
authors.lastname: Borrego
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D014178:Translocation, Genetic