[The psychotropic properties of bonnecor and ethacizine].
The comparative study of the psychotropic activity of new acyl derivatives of dibenzazepine and phenothiazine--bonnecor (chlorhydrate 3-carbethoxyamino-5(dimethylaminoacetyl) dibenzazepine and ethacizine (chlorhydrate 2-carbethoxyamino-10-(beta-diethyl-aminopropionyl)phenothiazine)--in the experiments on small laboratory animals showed the presence of the antidepressive, anxiolytic, antiamnesic and antihypoxic effects. The drugs exerted the psychotropic effects at administration in the doses exceeding those which influence the cardiovascular system. By the degree of the anxiolytic action bonnecor and ethacizine are inferior to diazepam, are as potent as trioxasine and are superior to meprobamat. The noted psychotropic action by its character and degree can serve as a beneficial supplement to the spectrum of the pharmacological activity of the studied compounds.
Voronina
T A
TA
Garibova
T L
TL
Barch
R
R
Rostock
A
A
Khromova
I V
IV
Artemenko
G N
GN
Zigemund
K
K
Hoffmann
V
V
D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000928:Antidepressive Agents; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D051379:Mice; D010640:Phenothiazines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents; D000928:Antidepressive Agents; D003984:Dibenzazepines; D010640:Phenothiazines; D011619:Psychotropic Drugs; C048166:tiracizine; C046818:ethacizine