title: [Role of surgery in the therapy of peptic ulcer after arrival of H2-blocking drugs].
abstract: This retrospective study was undertaken to determine if the advent of H2-blockers has altered the surgical treatment and the outcome of patients with peptic ulcer disease. The records of patients undergoing surgery for peptic ulcer disease at Montecchio Maggiore Hospital, Vicenza (Italy), from 1968 to 1977 (group A) and from 1979 to 1989 (group B) were reviewed. Data recorded included, ulcer location, surgical procedures (emergency or elective), indications for emergency surgery (perforation, bleeding). Statistical analysis was performed by means of the chi-square test. From 1968 to 1989, 15.810 surgical operations were performed: the indication was peptic ulcer disease in 398 cases (2.51%). The percentage of surgical operations performed for peptic ulcer was 3.54% in group A and 1.55% in group B. A marked decline in surgery for peptic ulcer was noted in group B, concerning both elective and emergency surgery; surgical interventions strongly decreased for both duodenal and gastric ulcer. This study demonstrates that H2-blockers have definitely altered the surgical treatment for peptic ulcer disease.
authors.affiliation: Divisione di Chirurgia Generale, Ospedale Civile di Montecchio Maggiore (VI).
authors.forename: S
authors.initials: S
authors.lastname: Perri
authors.forename: M
authors.initials: M
authors.lastname: Amendolara
authors.forename: E
authors.initials: E
authors.lastname: Breda
authors.forename: V
authors.initials: V
authors.lastname: Todarello
authors.forename: G
authors.initials: G
authors.lastname: Gallo
authors.forename: F
authors.initials: F
authors.lastname: Pietrangeli
authors.forename: G
authors.initials: G
authors.lastname: Meneghini
authors.forename: G F
authors.initials: GF
authors.lastname: Gelmi
mesh_terms: D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D004630:Emergencies; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy / Q000601:surgery*; D010438:Peptic Ulcer Hemorrhage / Q000601:surgery; D010439:Peptic Ulcer Perforation / Q000601:surgery; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications / Q000188:drug therapy / Q000601:surgery
chemical_list: D006635:Histamine H2 Antagonists