Expression of c-myc gene product in gastric carcinoma.
The expression of c-myc oncogene product was studied in 213 cases with gastric carcinoma by an immunoperoxidase method using a monoclonal antibody (MYC-1). Fifty (23.5%) of 213 tumors showed immunoreactivity to MYC-1. The distribution of c-myc-product-positive cells was observed mainly at the marginal area of the tumor. Excess reactivity to c-myc product occurred more frequently in invasive cancers than in localized cancers, and c-myc production expression in cancer tissue correlated well with peritoneal dissemination. Patients with c-myc-protein-positive tumor had significantly poorer prognosis than those with c-myc-protein-negative tumor in invasive gastric carcinomas, and the c-myc product status correlated well with the recurrence of cancer by peritoneal dissemination. These results suggest that the expression of c-myc gene product might be related to the proliferative activity of gastric carcinoma and serve as a new biologically relevant tumor marker for determining the prognosis.
Ninomiya
I
I
2nd Department of Surgery, School of Medicine, Kanazawa University, Japan.
Yonemura
Y
Y
Matsumoto
H
H
Sugiyama
K
K
Kamata
T
T
Miwa
K
K
Miyazaki
I
I
Shiku
H
H
D000818:Animals; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality; D005753:Gastric Mucosa / Q000737:chemistry; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis* / Q000276:immunology; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality; D015996:Survival Rate
D016271:Proto-Oncogene Proteins c-myc