title: A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.
abstract: Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM). Arachidonate 12-lipoxygenase purified from porcine leukocytes and human platelets, 15-lipoxygenase from rabbit reticulocytes and fatty acid cyclooxygenase from bovine vesicular glands were inhibited by the compound only at higher concentrations (IC50 = 2.3, 11, 5.2 and 2.5 microM, respectively).
authors.affiliation: Department of Biochemistry, Tokushima University School of Medicine, Japan.
authors.forename: G R
authors.initials: GR
authors.lastname: Reddy
authors.forename: N
authors.initials: N
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Hada
authors.forename: A C
authors.initials: AC
authors.lastname: Sackeyfio
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Hano
authors.forename: M
authors.initials: M
authors.lastname: Aida
authors.forename: T
authors.initials: T
authors.lastname: Nomura
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D016859:Lipoxygenase Inhibitors; D013329:Structure-Activity Relationship
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; C066727:artonin E; C057451:morusin