Oxidative damage to lipids within the inflamed human joint provides evidence of radical-mediated hypoxic-reperfusion injury.
Previous work has established the existence of a pathophysiological environment within the inflamed human joint, capable of sustaining a hypoxic-reperfusion event. Using four different assay systems (two standard and two novel) applied to synovial fluid for the assessment of lipid peroxidation, a series of studies demonstrate that exercise of the inflamed human knee promotes radical-mediated lipid peroxidation within the joint. The implication for novel antioxidant therapeutic approaches to inflammatory joint disease is discussed.
Merry
P
P
London Inflammation Group, London Hospital Medical College, UK.
Grootveld
M
M
Lunec
J
J
Blake
D R
DR
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D015427:Reperfusion Injury / Q000378:metabolism*; D013053:Spectrophotometry; D013582:Synovial Fluid / Q000737:chemistry