title: Indium-111-labeled leukocyte scan in detection of synthetic vascular graft infection: the effect of antibiotic treatment.
abstract: To determine the sensitivity and specificity of the indium-111-(111In) labeled leukocyte scan for prosthetic vascular graft infection in patients treated with antibiotic therapy, a retrospective study was performed. Of 41 consecutive 111In-labeled leukocyte scans performed to evaluate possible vascular graft infection, 23 scans were performed in patients treated with antibiotics. The average duration of antibiotic therapy was 21 days. Twelve positive and 11 negative scans for graft infection were found. By surgical and autopsy correlation of all positive cases, and clinical correlation (of all negative cases), there were 10 true-positive, 11 true-negative, 2 false-positive, and no false-negative scans for graft infections, for an overall sensitivity of 100% and specificity of 85%.
authors.affiliation: Department of Radiology, Medical University of South Carolina, Charleston 29425.
authors.forename: C J
authors.initials: CJ
authors.lastname: Chung
authors.forename: O A
authors.initials: OA
authors.lastname: Hicklin
authors.forename: J M
authors.initials: JM
authors.lastname: Payan
authors.forename: L
authors.initials: L
authors.lastname: Gordon
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001807:Blood Vessel Prosthesis; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013530:Surgical Wound Infection / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D007205:Indium Radioisotopes