title: Two indices of functional damage of the artery wall parallel the time course of irreversible narrowing in experimental vasospasm in the rabbit.
abstract: Autologous blood placed around the basilar artery caused angiographic narrowing with a biphasic time course. The first immediate phase was reversed by intraarterial papaverine; the second exhibited an increasing component of narrowing which was papaverine-resistant. In vitro studies showed that vessels became increasingly stiffer, less capable to develop active tone, and less responsive to vasoconstrictors and vasodilators. The papaverine-resistant component of angiographic narrowing (in vivo) could be directly correlated with loss of contractility and increased artery wall stiffness (in vitro).
authors.affiliation: Vermont Center for Vascular Research, University of Vermont, Burlington.
authors.forename: P
authors.initials: P
authors.lastname: Vorkapic
authors.forename: J A
authors.initials: JA
authors.lastname: Bevan
authors.forename: R D
authors.initials: RD
authors.lastname: Bevan
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D011859:Radiography; D012701:Serotonin / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014661:Vasoconstriction
chemical_list: D012701:Serotonin; D010208:Papaverine; D011188:Potassium; D009638:Norepinephrine