Pleomorphic (anaplastic) neuroblastoma in nude mice.
Two pleomorphic (anaplastic) neuroblastomas, from two children aged 1 and 6 years, were transplanted into nude mice. Two noteworthy observations were made. In one case, the transplanted tumor gave rise to a soft-tissue sarcoma. Moreover, in both cases hepatic metastases were associated with a striking modification of murine hepatocytes, resulting in hyperchromatic and dysplastic nuclei. The latter finding was particularly evident in the hepatic areas surrounding all metastases of pleomorphic (anaplastic) neuroblastoma cells.
Cozzutto
C
C
Department of Pathology, G. Gaslini Research Hospital, Genoa, Italy.
Cornaglia-Ferraris
P
P
D000818:Animals; D015139:Blotting, Southern; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008114:Liver Neoplasms, Experimental / Q000556:secondary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000473:pathology; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm