The pivotal role of the Leu-CAM and ICAM molecules in human leukocyte adhesion.
Cellular adhesion is of fundamental importance in leukocyte physiology. It is a complex, strictly regulated process, which involves the participation of several cell surface glycoproteins. Among the most important are the Leu-CAMs or the CD11/CD18 integrin receptors, and their adhesion ligands ICAM-1 (CD54) and ICAM-2. In this review we summarize some recent work on various aspects of these molecules.
Gahmberg
C G
CG
Department of Biochemistry, University of Helsinki, Finland.
Nortamo
P
P
Kantor
C
C
Autero
M
M
Kotovuori
P
P
Hemiö
L
L
Salcedo
R
R
Patarroyo
M
M
D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D018845:CD11 Antigens; D018821:CD18 Antigens; D002413:Cations, Divalent / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism; D007239:Infections / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1; D007962:Leukocytes / Q000502:physiology*; D010703:Phorbol Esters / Q000494:pharmacology; D016028:Receptors, Leukocyte-Adhesion / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000378:metabolism
D015703:Antigens, CD; D018845:CD11 Antigens; D018821:CD18 Antigens; D002413:Cations, Divalent; D015815:Cell Adhesion Molecules; C065289:ICAM2 protein, human; D010703:Phorbol Esters; D016028:Receptors, Leukocyte-Adhesion; D011993:Recombinant Fusion Proteins; D018799:Intercellular Adhesion Molecule-1