Aqueous humor pilocarpine and timolol levels after instillation of the single drug or in combination.
Aqueous humor levels of pilocarpine and timolol in rabbits after administration of either 2% pilocarpine or 0.5% timolol in single-drug solutions were compared with the concentrations found after instillation of a fixed combination of 0.5% timolol and 2% pilocarpine drops. Time intervals considered were 15 min, 30 min, 1 hr, 4 hr, and 8 hr after application. Drug concentrations were analyzed in individual aqueous samples by high-performance liquid chromatography. No statistically significant differences in either pilocarpine or timolol concentrations in aqueous humor were found at any time tested between the single-drug preparations and the combination.
Ellis
P P
PP
Department of Ophthalmology, University of Colorado Health Sciences Center, Denver 80262.
Wu
P Y
PY
Riegel
M
M
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D010862:Pilocarpine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D013999:Timolol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004338:Drug Combinations; D010862:Pilocarpine; D013999:Timolol