Vascularized bone marrow transplantation (VBMT): induction of stable mixed T-cell chimerism and transplantation tolerance in unmodified recipients.
In this preliminary report, our model of VBMT across a semiallogeneic barrier consistently brings about antigen-specific host tolerance with absence of GVHD in the majority of recipients. No immunologic or radiologic intervention was utilized. These results emphasized a potentially important mechanism for low-level stable mixed lymphoid chimerism (SMLC) in tolerance induction, independent of immune suppressive effects due to irradiation or immunopharmacologic intervention.
Yazdi
B
B
Department of Surgery, University of California, Irvine 92717.
Patel
M P
MP
Ramsamooj
R
R
Llull
R
R
Achauer
B M
BM
Black
K S
KS
Hewitt
C W
CW
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002678:Chimera; D006086:Graft vs Host Disease / Q000517:prevention & control; D006614:Hindlimb / Q000637:transplantation*; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous