title: Porcine pancreastatin has no effect on endocrine secretion from the pig pancreas.
abstract: We investigated the effects of porcine pancreastatin on the endocrine and unstimulated exocrine secretion of isolated, perfused porcine pancreas. Pancreastatin in a concentration of 10(-8) mol/l had no effect on basal secretion of insulin, glucagon and somatostatin at a perfusate glucose concentration of 5 mmol/l (n = 4) and neither at 10(-8) nor 10(-7) mol/l influenced the hormone responses to acute elevations of perfusate glucose concentration from 3.5 to 11 mmol/l (n = 7). This elevation strongly stimulated insulin secretion and inhibited glucagon secretion. Exocrine secretion was not affected by pancreastatin. The results suggest that pancreastatin does not directly influence pancreatic secretion.
authors.affiliation: Institute of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark.
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: C G
authors.initials: CG
authors.lastname: Ostenson
authors.forename: H
authors.initials: H
authors.lastname: Harling
authors.forename: T
authors.initials: T
authors.lastname: Messell
mesh_terms: D000818:Animals; D053379:Chromogranin A; D005934:Glucagon / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010477:Perfusion; D013004:Somatostatin / Q000378:metabolism*; D013552:Swine
chemical_list: D053379:Chromogranin A; D007328:Insulin; D010187:Pancreatic Hormones; C050836:pancreastatin; D013004:Somatostatin; D005934:Glucagon