Significant increase of urinary mucoprotein in environmental-cadmium-exposed Japanese subjects.
Urinary mucoprotein (U-MP) was determined in 169 Japanese environmental-cadmium-exposed and 81 non-exposed subjects. Urinary total protein, albumin, beta 2-microglobulin (beta 2-MG), cadmium (Cd) and creatinine were also measured. Significant increases in U-MP and other proteins were found in the Cd-exposed subjects. Significant correlations between each protein were seen in the Cd-exposed and the total group of subjects. U-MP was highly correlated with urinary beta 2-MG and their correlation coefficient was the highest in the total group of subjects. beta 2-MG was the most sensitive indicator among them to detect Cd-induced renal dysfunction, although beta 2-MG is degraded in urine with a pH less than 5.5 U-MP is an acid-soluble protein. Therefore, U-MP is also available for studies on renal dysfunction caused by exposure to Cd, in conjunction with beta 2-MG.
Kido
T
T
Department of Hygiene and Public Health, Kanazawa Medical University, Ishikawa, Japan.
Honda
R
R
Tsuritani
I
I
Ishizaki
M
M
Yamada
Y
Y
Nakagawa
H
H
Nogawa
K
K
D000419:Albuminuria / Q000652:urine; D002104:Cadmium / Q000633:toxicity* / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007564:Japan; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D009088:Mucoproteins; D001613:beta 2-Microglobulin; D002104:Cadmium; D003404:Creatinine