title: Interleukin-6 response to deliberate colonization of the human urinary tract with gram-negative bacteria.
abstract: Intravesical inoculation of patients with Escherichia coli provided an opportunity to examine the interleukin-6 (IL-6) response to a gram-negative bacterial urinary tract infection in humans. All patients secreted IL-6 as a result of infection. Urinary IL-6 was not continuously secreted but appeared as a series of similar peaks during the first 48 h after infection. There was no significant difference in the ability to trigger IL-6 secretion between isogenic adhering or nonadhering strains, but a threshold concentration of 10(5) bacteria per ml of urine was necessary to fully stimulate IL-6 secretion. There was no detectable increase in IL-6 levels in the serum of the colonized individuals, suggesting mainly local IL-6 production. These results demonstrate that IL-6 is a part of the human mucosal response to gram-negative urinary tract infections.
authors.affiliation: Department of Clinical Immunology, University of Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Hedges
authors.forename: P
authors.initials: P
authors.lastname: Anderson
authors.forename: G
authors.initials: G
authors.lastname: Lidin-Janson
authors.forename: P
authors.initials: P
authors.lastname: de Man
authors.forename: C
authors.initials: C
authors.lastname: Svanborg
mesh_terms: D000328:Adult; D000368:Aged; D001422:Bacterial Adhesion; D004927:Escherichia coli Infections / Q000276:immunology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D015850:Interleukin-6 / Q000097:blood / Q000652:urine*; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D011971:Receptors, Immunologic / Q000032:analysis; D019947:Receptors, Interleukin-6; D014552:Urinary Tract Infections / Q000276:immunology* / Q000652:urine
chemical_list: D007071:Immunoglobulin A, Secretory; D015850:Interleukin-6; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6