Indium-111-chloride and three-phase bone scintigraphy: a comparison for imaging experimental osteomyelitis.
To investigate the utility of indium-111-chloride (111In-Cl) imaging in detecting osteomyelitis complicating surgical or fracture sites, the proximal tibia of 11 dogs were experimentally infected with Staphylococcus aureus after creation of a cortical defect. The contralateral limb served as a sham-operated control. Animals were serially imaged by radiography, three-phase technetium-99m-methylene diphosphonate (99mTc-MDP) scintigraphy, and 111In-Cl scintigraphy. There was a significant difference between infected (1.93) and noninfected (1.32) limb's tibia/femur count density ratios on 24-hr (p = 0.0001) and 72-hr (p = 0.0001) 111In-Cl images. A smaller difference was found for 99mTc-MDP bone-phase tibia/femur ratios (p = 0.0199). Using receiver operator characteristic analysis of tibia/femur ratios, a sensitivity of 61%, specificity of 88%, and positive (75%) and negative (79%) predictive values were determined for the 24-hr 111In-Cl images. Indium-111-chloride was superior to 99mTc-MDP in differentiating infected and noninfected operative sites.
Hoskinson
J J
JJ
Department of Urban Practice, University of Tennessee College of Veterinary Medicine, Knoxville.
Daniel
G B
GB
Patton
C S
CS
D000818:Animals; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging; D007204:Indium; D007205:Indium Radioisotopes; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate; D013977:Tibia / Q000000981:diagnostic imaging; D014946:Wound Infection / Q000000981:diagnostic imaging*
D007205:Indium Radioisotopes; D007204:Indium; C020758:indium trichloride; D013669:Technetium Tc 99m Medronate