Serum activities of AP, gamma-GT, G1DH and GPT in the first four days after bile duct obstruction and ethionine in the rat.
Following sham operation and bile duct obstruction (BDO), Wistar rats received ethionine, which inhibits protein synthesis in the liver. Earlier studies revealed, that the increase of activity of AP after BDO is the result of a de novo-synthesis of enzyme protein in the liver. With regard to serum activities of the enzymes G1DH, GPT and gamma-GT, no influence of de novo-synthesis after BDO has so far been certified, but these enzymes have only been investigated in the early phase after BDO, for up to 24 h under protein synthesis inhibition. In the present study, the protein synthesis inhibition was extended up to the fourth day after BDO. Signs of de novo-synthesis after BDO could also be detected in G1DH, GPT and gamma-GT.
Putzki
H
H
Department of General Surgery, Medical School, Hannover, F.R.G.
D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002779:Cholestasis / Q000201:enzymology*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase