title: Immunoglobulin A mediation of murine nasal anti-influenza virus immunity.
abstract: Most mice which have recovered from influenza virus infection are immune to reinfection with the same influenza virus. This immunity could be abrogated by the intranasal instillation of anti-immunoglobulin A (anti-IgA) but not of anti-IgG or anti-IgM antiserum. Thus, IgA is the major, if not the sole, mediator of nasal immunity to influenza virus in immunocompetent mice.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0266.
authors.forename: K B
authors.initials: KB
authors.lastname: Renegar
authors.forename: P A
authors.initials: PA
authors.lastname: Small
mesh_terms: D000818:Animals; D005260:Female; D007108:Immune Tolerance; D007113:Immunity, Innate; D007070:Immunoglobulin A / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009296:Nasal Cavity / Q000382:microbiology*; D009975:Orthomyxoviridae / Q000254:growth & development / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology; D014779:Virus Replication
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M