[Preliminary study on the cellular immune abnormality in rheumatoid arthritis].
The cellular immunological abnormalities in 21 patients with rheumatoid arthritis (RA) were studied with flow cytometer. In the peripheral blood monocytes (PBM) from patients with active RA the number of HLA-DR positive cells were remarkably increased. The activity of NK cells and Leull C+ cells reduced to 1/2-1/3 of the normal limits. The AMLR and mitogen-inducing reaction decreased significantly. These data suggest that the changes of cellular immune reaction and immunoregulation may be related to the pathogensis of RA.
Xu
W D
WD
General Hospital of Chinese PLA.
Li
Y
Y
Liu
C G
CG
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens