title: [Beta-blockers in collyria and their secondary effects].
abstract: Beta-blockings in collyrium are much used in ophthalmology, in the treatment of chronic glaucoma with open angle, because they decrease the OT with 25-30%. They are well accepted, but have systemic effects. The collyria are drained by the lacrimal system and 80% of the product is absorbed by the nasal mucosa. If the active substance penetrates into the circulatory system, avoiding hepatic metabolization, it reaches the target organs in a rather considerable amount and leads sometimes to adverse effects, as a consequence of blockage of the specific receptors. Although these effects are not frequent in the usual practice, they might decompensate a poor cardiac or respiratory function. The physician has to take into account the cardio-respiratory state of the patients and to recommend concomitantly drugs that lower the myocardial conduction or contractibility.
authors.affiliation: Policlinica Specială nr. 2, Bucureşti.
authors.forename: S
authors.initials: S
authors.lastname: Mihail
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D002908:Chronic Disease; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D009883:Ophthalmic Solutions
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions