First analysis of the F508 deletion in cystic fibrosis patients from the GDR.
Cystic fibrosis (CF) patients (n = 157) from the GDR were analysed for the occurrence of the recently discovered 3bp deletion causing CF. About 50% of all investigated patients were homozygotes and about 30% heterozygotes for this deletion. Of the analysed CF chromosomes from these patients, 62% carry the deletion, which is in strong linkage disequilibrium with the KM19 restriction fragment length polymorphism allele 2 and the 1/2 XV2c/KM19 haplotype.
Grade
K
K
Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der DDR, Berlin.
Will
K
K
Szibor
R
R
Gedschold
J
J
Brückner
R
R
Bauer
I
I
Giermann
K
K
Gorki
H
H
Hein
J
J
Brell
U
U
D002872:Chromosome Deletion; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D005860:Germany, West; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length