title: "Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia.
abstract: We report a case of acute monocytic leukemia (FAB-5a) with a very aggressive clinical course and multiple chromosomal abnormalities. There were several sublines, each with trisomy 8 and a translocation involving 3q13.3 as a common breakpoint region. This region is an uncommon site of chromosomal breakage in malignancies and has not hitherto been reported as a breakpoint site in "jumping" translocations.
authors.affiliation: Department of Laboratory Hematology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Reis
authors.forename: I D
authors.initials: ID
authors.lastname: Dubé
authors.forename: P H
authors.initials: PH
authors.lastname: Pinkerton
authors.forename: J
authors.initials: J
authors.lastname: Chen-Lai
authors.forename: J B
authors.initials: JB
authors.lastname: Robinson
authors.forename: R J
authors.initials: RJ
authors.lastname: Klock
authors.forename: J S
authors.initials: JS
authors.lastname: Senn
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D015703:Antigens, CD