Dopaminergic drugs influence the intensity of catalepsy induced by microinjections of carbachol into the reticular formation.
Carbachol microinjections into the mesencephalic and pontine reticular formation in rats induced intense and long-lasting catalepsy. Systemically administered haloperidol potentiated, while apomorphine and L-DOPA reduced the cataleptogenic effect of carbachol. These results indicate the existence of functional relations between the cholinergic cataleptogenic mechanism in the reticular formation and the dopaminergic system. They are interpreted in the light of known anatomical ascending and descending interconnections between the reticular formation and basal ganglia.
Elazar
Z
Z
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.
Ganchrow
D
D
Paz
M
M
Rabinowitz
R
R
Paz
Z
Z
Korczyn
A D
AD
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001933:Brain Stem / Q000502:physiology; D002217:Carbachol; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D015259:Dopamine Agents / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007267:Injections; D007279:Injections, Subcutaneous; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects
D015259:Dopamine Agents; D007980:Levodopa; D002217:Carbachol; D006220:Haloperidol; D001058:Apomorphine