Localization of the gene for the trans-acting transcription factor Sp1 to the distal end of mouse chromosome 15.
The mouse chromosomal location for the gene (Sp1-1) encoding the trans-acting transcription factor Sp1 has been determined. Analysis of restriction fragment length polymorphisms in recombinant inbred, congenic, and interspecific backcross mice using human and mouse cDNA probes demonstrated that Sp1-1 is a single gene closely linked to the mammary tumor virus integration site-1 (Int-1) on the distal end of chromosome 15. Sp1 is a zinc finger protein, but Sp1-1 is not closely linked to any of the other zinc finger protein genes that have been mapped in mouse. Int-1 and other markers flanking the Sp1-1 locus are part of a conserved linkage group represented on human chromosome 12q.
Saffer
J D
JD
Jackson Laboratory, Bar Harbor, Maine 04609.
Thurston
S J
SJ
Annarella
M B
MB
Compton
J G
JG
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D009115:Muridae / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D016329:Sp1 Transcription Factor / Q000235:genetics*; D013045:Species Specificity; D016335:Zinc Fingers
D005819:Genetic Markers; D016329:Sp1 Transcription Factor; D004247:DNA