[The reactivity of postsynaptic alpha 1- and alpha 2-adrenoreceptors and arterial pressure in acute pancreatitis].
Experiments were conducted on pithed rats with acute pancreatitis and on falsely operated on animals (ether-laparotomy stress) to study the reactivity of vascular alpha 1- and alpha 2-adrenoreceptors and its role in changes in arterial pressure. Selective change in the reactivity of alpha 2-adrenoceptors alone was revealed in both groups. Stable reduction of vascular alpha 2-adrenergic reactivity (by 57-58%) and arterial pressure was recorded in animals with acute pancreatitis. In falsely operated on animals, in contrast, the values of these indices exceeded the control level. In animals with a functioning central nervous system inhibition of alpha 2-adrenergic reactivity correlated with change in arterial pressure only in the initial (3-4 hours) hemorrhagic phase of acute pancreatitis.
Simavorian
P S
PS
Martirosian
O M
OM
Shirinian
E A
EA
D000208:Acute Disease; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology; D003655:Decerebrate State / Q000503:physiopathology; D007813:Laparotomy; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D010195:Pancreatitis / Q000503:physiopathology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; C015603:azepexole; D003000:Clonidine