A G protein-mediated inhibition of voltage-dependent Ca2+ influx in beta cells underlies somatostatin inhibition of insulin secretion.
Rajan
A S
AS
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Xiang
H D
HD
Hsu
W H
WH
Kunze
D L
DL
Boyd
A E
AE
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D013004:Somatostatin / Q000494:pharmacology; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D015220:Calcium Channels; D007328:Insulin; D015221:Potassium Channels; D010566:Virulence Factors, Bordetella; D013004:Somatostatin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D002118:Calcium