[The analgesic action of narcotic analgesics and clopheline after the ionizing irradiation of rats].
The ionizing radiation (150 Gy) extended the rat tail flick latency, decreased the pain-relief effects of morphine and opioids and enhanced the analgesic effect of clopheline. The radiation was followed by a decrease of vocalization threshold with a reduction of morphine- and clopheline-induced analgesia. Naloxone (0.1 mg/kg) eliminated the postradiation analgesia and did not change the hyperalgesic effect of the radiation.
Ignatov
Iu D
IuD
Zaĭtsev
A A
AA
Abdrakhmanov
A A
AA
D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D003000:Clonidine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D005720:Gamma Rays; D006358:Hot Temperature; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013997:Time Factors
D000701:Analgesics, Opioid; D003000:Clonidine