title: Early-onset Alzheimer's disease in 2 large Belgian families.
abstract: Familial Alzheimer's disease (FAD) is a dominantly inherited condition that may present with an early onset, and myoclonus occurs frequently in the course of the disease. We report clinical and neuropathologic data on 2 large Belgian families with FAD in which we obtained 17 autopsies of the CNS. In family A, each of 11 autopsies had the typical neuropathologic features of Alzheimer's disease (AD), and there were a few cerebellar plaques in the molecular layer. In family B, in addition to the typical characteristics of AD in 6 autopsies, there were numerous amyloid plaques in the cortical cerebellar layers. In both families, we immunostained the amyloid deposits for the A4 protein, and they were negative for prion-associated protein immunoreactivity.
authors.affiliation: Department of Neurology, University Hospital, Wilrijk, Belgium.
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Gheuens
authors.forename: M
authors.initials: M
authors.lastname: Bruyland
authors.forename: P
authors.initials: P
authors.lastname: Cras
authors.forename: A
authors.initials: A
authors.lastname: Vandenberghe
authors.forename: C L
authors.initials: CL
authors.lastname: Masters
authors.forename: K
authors.initials: K
authors.lastname: Beyreuther
authors.forename: R
authors.initials: R
authors.lastname: Dom
authors.forename: C
authors.initials: C
authors.lastname: Ceuterick
authors.forename: U
authors.initials: U
authors.lastname: Lübke
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D001530:Belgium; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009454:Neurofibrils / Q000473:pathology; D010375:Pedigree