Beneficial effect of upper thoracic epidural anesthesia in experimental hemorrhagic shock in dogs: influence of circulating catecholamines.
The question as to whether reduction of plasma catecholamine concentration contributes to the beneficial effects of upper thoracic epidural anesthesia on survival during hemorrhagic shock was examined. Twenty-six dogs were anesthetized with halothane and nitrous oxide, and blood was withdrawn to reduce the mean arterial blood pressure (MAP) to 40 mmHg. The 12 dogs in group A received both upper thoracic epidural anesthesia before the hemorrhage and intravenous infusion of epinephrine (450 ng.kg-1.min-1) and norepinephrine (150 ng.kg-1.min-1) during hemorrhage. The 14 dogs in group B received none of these. At 20 min after the start of the bleeding, plasma catecholamine concentrations were increased in both groups more than ten-fold. There were no significant intergroup differences with respect to these concentrations at any point during the experimental period. During the 100-min period of hemorrhage, 1 of the 12 animals in group A and 10 of the 14 in group B died. A significant difference in survival was seen between the two groups over the 100-min hypotensive period (P less than 0.01 by the generalized Wilcoxon test). These results suggest that the survival benefit of upper thoracic epidural anesthesia cannot be explained simply by differences in the level of catecholamines in the plasma, and that perhaps differences in the level of catecholamines at the nerve endings or other factors may be more important.
Shibata
K
K
Department of Anesthesiology, School of Medicine, Kanazawa University, Japan.
Yamamoto
Y
Y
Kobayashi
T
T
Murakami
S
S
D000767:Anesthesia, Epidural; D000818:Animals; D004285:Dogs; D004837:Epinephrine / Q000097:blood / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000097:blood / Q000502:physiology*; D012771:Shock, Hemorrhagic / Q000401:mortality / Q000503:physiopathology*; D015996:Survival Rate
D009638:Norepinephrine; D004837:Epinephrine