Antimicrobial interference with bacterial mechanisms of pathogenicity: effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells.
The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.
Gorby
G L
GL
Section of Infectious Diseases, Omaha VA Medical Center, Nebraska.
McGee
Z A
ZA
D017963:Azithromycin; D015153:Blotting, Western; D002478:Cells, Cultured; D004847:Epithelial Cells; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D010861:Fimbriae, Bacterial / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009061:Mouth Mucosa / Q000166:cytology; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000472:pathogenicity* / Q000648:ultrastructure
D004917:Erythromycin; D017963:Azithromycin