Tumor growth fraction in cervical carcinoma.
Thirty-one cervical carcinomas have been studied immunohistochemically to determine tumor growth fraction by using the monoclonal antibody Ki-67, which reacts with a nuclear antigen expressed only by proliferating cells. The growth fraction of individual tumor is estimated as the percentage of stained nuclei in a population of 1000 tumor cells. There is a good correlation of the growth fraction measured by Ki-67 with mitotic index and high histological grade of cervical carcinoma. This study, together with that of D. C. Brown, D. Cole, K. C. Gatter, and D. Y. Mason [Brit. J. Cancer 57(2), 178-181 (1988)], shows the usefulness of Ki-67 in the evaluation of growth fraction in cervical carcinoma.
Wong
W S
WS
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Shatin, New Territories.
McGuire
L J
LJ
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008875:Middle Aged; D008940:Mitotic Index; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D019394:Ki-67 Antigen