Endometrial antibodies versus CA-125 for the detection of endometriosis.
Detection of endometrial antibodies using an indirect immunofluorescence method along with a well-established human endometrial carcinoma cell line was evaluated and compared with CA-125 for detecting endometriosis. Two hundred two patient sera from the infertility, gynecological, and gynecological oncology services were evaluated. The sensitivity for antibody testing was 83.1% with a specificity of 78.8%, in contrast to a sensitivity of 27.3% and a specificity of 82.6% for CA-125. These preliminary findings offer promise that antibody detection methods may be a useful adjunct in the diagnosis of endometriosis.
Wild
R A
RA
University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Hirisave
V
V
Bianco
A
A
Podczaski
E S
ES
Demers
L M
LM
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D004717:Endometrium / Q000276:immunology*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D009367:Neoplasm Staging; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate; D001323:Autoantibodies; D014408:Biomarkers, Tumor