Induction of sister chromatid exchanges with hypotonic treatment.
Hypotonic NaCl solutions and diluted culture medium were tested for induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CA). Hypotonic treatment conditions were found to induce high frequencies of CA and SCEs. However, an increase in SCEs was observed only in cells that also had CA. Possible lesions and mechanisms leading to SCEs and CA are discussed.
Kröger
I
I
Freie Universität Berlin, Institut für Genetik, Federal Republic of Germany.
Nowak
C
C
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D007038:Hypotonic Solutions / Q000494:pharmacology*; D008677:Metaphase; D009994:Osmolar Concentration; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology
D007038:Hypotonic Solutions; D012965:Sodium Chloride