title: Effects of somatostatin and motilin on the motor and myoelectrical activity of the canine stomach and small intestine in vivo.
abstract: The experiments were performed on six starved dogs with chronic fistula in the stomach and small intestine and with chronically implanted electrodes on the smooth-muscle wall of these organs. Motilin (15-25 ng/kg i.v.) induced fastedtype peristaltic contractions accompanied by migrating myoelectrical spike activity in the stomach and small intestine. Somatostatin (0.5-2 micrograms/kg i.v.) inhibited the spontaneous contractile activity and the spike potentials in both organs. The antagonistic effect of somatostatin on the spontaneous and motilin-induced contractions resembled the effect of atropine and probably resulted from the decreased acetylcholine release in the cholinergic neurons.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences.
authors.forename: K
authors.initials: K
authors.lastname: Milenov
authors.forename: A
authors.initials: A
authors.lastname: Bocheva
authors.forename: M
authors.initials: M
authors.lastname: Vassileva
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004567:Electrodes, Implanted; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009037:Motilin / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
chemical_list: D013004:Somatostatin; D009037:Motilin; D001285:Atropine