Homozygous condition for a BrdU-requiring fragile site on chromosome 12.
A rare BrdU-sensitive fragile site, designated FRA12C*RQ24.2 has a relatively high frequency in the normal population. It can be demonstrated in a heterozygous and homozygous condition. There is no evidence that a phenotypic abnormality is associated with the expression of this site. A comparison with the fragile site FRA10B*RQ25.2 has revealed common features with FRA12C*RQ24.2.
Voiculescu
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Institut für Humangenetik und Anthropologie der Universität, Freiburg, Federal Republic of Germany.
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Schempp
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D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002881:Chromosomes, Human, Pair 12; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008677:Metaphase
D001973:Bromodeoxyuridine