Manic depressive illness not linked to factor IX region in an independent series of pedigrees.
We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.
Gejman
P V
PV
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
Detera-Wadleigh
S
S
Martinez
M M
MM
Berrettini
W H
WH
Goldin
L R
LR
Gelernter
J
J
Hsieh
W T
WT
Gershon
E S
ES
D001714:Bipolar Disorder / Q000235:genetics*; D005164:Factor IX / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D005164:Factor IX