[Effect of H1- and H2-histamine receptor blockaders on lesions of the gastric mucosa evoked by exogenous histamine in guinea pigs].
It was demonstrated in experiments on guinea pigs with the use of a histamine model of ulcerogenesis that blocking agents of H1-histamine receptors produced a more marked gastro-protective effect than H2-antagonists. The results of the study confirm the hypothesis that histamine-induced ulceration of the gastric mucosa occurs through the mediation of H1-receptors. H2-histamine receptors play a secondary role in this process.
Karevina
T G
TG
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects*; D006168:Guinea Pigs; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006632:Histamine