The relative dependence of calcium antagonists and neuroleptics binding to brain and heart receptors on drug lipophilicity.
QSAR analysis of the binding of calcium antagonists to brain and heart tissue shows that relative binding to brain tissue increases with increasing octanol/water partition coefficients. A number of antischizophrenic drugs follow the same pattern.
Rojratanakiat
W
W
Department of Chemistry, Pomona College, Claremont, CA 91711.
Hansch
C
C
D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D014150:Antipsychotic Agents; D002121:Calcium Channel Blockers