Some pharmacological properties of perhydro-1,4-thiazepine and perhydro-1,2,5-dithiazepine derivatives.
Some newly synthesized perhydro-1,2,5-dithiazepine derivatives have antihistaminic, anticholinergic and spasmolytic properties. One perhydro-1,4-thiazepine derivative, compound 3, produces also a weak local anesthetic effect. The activity of the investigated compounds is lower than that of reference compounds; diphenhydramine, antazoline and papaverine.
Strzelczyk
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Department of Biochemistry, Pharmacology and Biology, Military Medical Academy, Lódź, Poland.
Matyjewska
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Strózyński
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D000779:Anesthetics, Local / Q000633:toxicity; D000818:Animals; D003315:Cornea / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000633:toxicity*; D011817:Rabbits; D013841:Thiazepines / Q000633:toxicity*
D000779:Anesthetics, Local; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D013841:Thiazepines