title: Timing of ovulation in spontaneous and induced cycles.
abstract: We studied 30 spontaneous cycles, 30 cycles induced with clomiphene citrate, and 30 cycles induced with human menopausal gonadotropin-human chorionic gonadotropin to evaluate the pattern of the following parameters and their predictive value in timing ovulation: basal body temperature; cervical mucus; mean follicular diameter; serum LH and 17-beta-estradiol; and urinary LH. Compared with the spontaneous cycles, in the cycles induced with clomiphene citrate the cervical score was significantly lower on the 4 days preceding ovulation, serum LH was higher in the early follicular phase, and serum 17-beta-estradiol was significantly higher in the pharmacologically treated cycles. The highest predictive values in all groups of cycles were obtained by considering the following combinations of parameters: serum 17-beta-estradiol and LH concentrations; mean follicular diameter as shown by ultrasonography and urinary LH as determined by a rapid method.
authors.affiliation: First Department of Obstetrics and Gynecology, University of Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Fedele
authors.forename: D
authors.initials: D
authors.lastname: Brioschi
authors.forename: M
authors.initials: M
authors.lastname: Dorta
authors.forename: F
authors.initials: F
authors.lastname: Parazzini
authors.forename: L
authors.initials: L
authors.lastname: Bocciolone
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology; D002584:Cervix Uteri / Q000502:physiology; D002996:Clomiphene / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008596:Menotropins / Q000627:therapeutic use; D010053:Ovary / Q000000981:diagnostic imaging; D010060:Ovulation / Q000502:physiology*; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone