title: Rectal electrogenic secretion--is it a putative indicator of intestinal secretory status induced by nutritional deprivation in the rat?
abstract: Intestinal secretion is enhanced by starvation in rats. The rectum from fed and 3-day-starved rats generates a basal electrogenic ion transfer (short-circuit current) in vitro which is mainly electrogenic Na+ absorption (amiloride-sensitive, 66-71%) with a small component of electrogenic chloride secretion (furosemide-sensitive, 14-22%). Bethanechol, a muscarinic agonist, caused an increase in the short-circuit current (mainly furosemide-sensitive chloride secretion) and potential difference in rectums from both fed and starved rats but the respective values for the starved animals were 100% and 64% greater. In starvation, the rat rectum is an indicator of intestinal secretory status. The result warrants investigation of human rectal electrogenic secretion in nutritional deprivation.
authors.affiliation: Department of Biomedical Science, University of Sheffield.
authors.forename: R J
authors.initials: RJ
authors.lastname: Levin
authors.forename: A J
authors.initials: AJ
authors.lastname: Parker
mesh_terms: D000042:Absorption; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism; D004594:Electrophysiology; D007419:Intestinal Secretions / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D012007:Rectum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013217:Starvation / Q000378:metabolism*
chemical_list: D001626:Bethanechol Compounds; D002712:Chlorides; D018723:Bethanechol; D000584:Amiloride; D012964:Sodium