Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics.
Long-term glycaemic control measured by glycosylated haemoglobin concentration was compared in hypertensive NIDD's taking placebo, alpha-blockers, beta-blockers (alone and in combination) and an ACE inhibitor (enalapril) each for 4 months. Alpha-blockade caused no deterioration in long-term glycaemic control in NIDD's. Beta-blockers caused a deterioration in glycaemic control in NIDD's (with some adverse effects on lipid profile). This was especially apparent with the lipophilic beta-blocker P. Concurrent use of an alpha-blocker with a beta-blocker prevents the deterioration due to beta-blockade. The ACE inhibitor, enalapril caused an improvement in long-term glycaemic control without alteration of lipid control in NIDD's.
Whitcroft
I A
IA
St. Bartholomew's Hospital Medical Colle, London, United Kingdom.
Thomas
J M
JM
Rawsthorne
A
A
Wilkinson
N
N
Thompson
H
H
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001786:Blood Glucose; D004656:Enalapril; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids