title: Case report: oxypertin-induced keratopathy?
abstract: A 45 year old caucasian female underwent longterm psychiatric treatment including Oxypertin. Ocular changes occurred in close time relation with the treatment of oxypertin: Corneal sicca-syndrome was found at first in both eyes, later on severe corneal scaring, vascularisation, and thinning indicated the need of further ophthalmologic treatment. Although the psychiatric treatment was stopped the ocular effects remained and keratoplasty had to be performed in the right eye. A case report is given to show the clinical and histopathologic aspect of the cornea in a patient undergoing treatment with a new designed and widely used neuroleptic drug.
authors.affiliation: Department of Ophthalmology, University Erlangen-Nürnberg, Federal Republic of Germany.
authors.forename: R G
authors.initials: RG
authors.lastname: Burk
authors.forename: K W
authors.initials: KW
authors.lastname: Ruprecht
mesh_terms: D003316:Corneal Diseases / Q000139:chemically induced* / Q000601:surgery; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D010879:Piperazines