Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation.
The antiperoxidative effects of 35 phenolic compounds, most of them belonging to the flavonoid class, were investigated using CCl4-induced peroxidation of rat liver microsomes. This system was rather insensitive to gallic acid, methyl gallate and ellagic acid. Nevertheless it was inhibited by flavonoids and structure/activity relationships were established. The most potent compounds were gardenin D, luteolin, apigenin (flavones), datiscetin, morin, galangin (flavonols), eriodictyol (flavanone), amentoflavone (biflavone) and the reference compound, (+)-catechin. The natural polymethoxyflavone gardenin D has shown a potency comparable to that of (+)-catechin and higher than that of silybin. Thus, it may be considered as a new type of natural antioxidant with potential therapeutical applications.
Cholbi
M R
MR
Departamento de Farmacologia y Farmacotecnia, Facultad de Farmacia, Valencia, Spain.
Paya
M
M
Alcaraz
M J
MJ
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D004610:Ellagic Acid / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D005707:Gallic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005419:Flavonoids; D044948:Flavonols; D008054:Lipid Peroxides; D010636:Phenols; D004610:Ellagic Acid; D005707:Gallic Acid