Actions of carbaryl on the ionic transport across the isolated skin of Rana esculenta.
1. Carbaryl, a carbamate used as a pesticide, increases the short-circuit current (SCC) across the isolated frog skin in a dose-dependent manner. 2. This effect is due to the stimulation of sodium absorption and chloride secretion. 3. Carbaryl action on short-circuit current is unrelated to its inhibitory power on cholinesterase; this statement is supported by two experimental results: (a) carbaryl is equally active on both sides of the skin, (b) atropine pretreatment does not inhibit the carbaryl action on SCC.
Ardizzone
C
C
Pharmaco-Biological Department, University of Bari, Italy.
Krokos
H
H
Lippe
C
C
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D012721:Carbaryl / Q000494:pharmacology*; D002712:Chlorides / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D011893:Rana esculenta; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000378:metabolism*
D002712:Chlorides; D001285:Atropine; D012964:Sodium; D012721:Carbaryl