An HhaI polymorphism is present in factor IX genes of Asian subjects.
Hemophilia B is caused by decreased factor IX procoagulant activity. An HhaI restriction site polymorphism near the factor IX gene has been detected by the polymerase chain reaction. Frequency and linkage data already observed in Caucasians are confirmed and the polymorphism is also prevalent in the factor IX genes of Black and Asian populations.
Reiner
A P
AP
Puget Sound Blood Center, Seattle, WA 98104.
Thompson
A R
AR
D044466:Asian People; D044383:Black People; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005164:Factor IX / Q000235:genetics*; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
D005164:Factor IX; D015252:Deoxyribonucleases, Type II Site-Specific; C037130:GCGC-specific type II deoxyribonucleases