title: Lack of acute effects of 20 mT, 50 Hz magnetic fields on murine haemopoiesis.
abstract: Some epidemiological studies have drawn attention to a possible association between exposure to extremely low-frequency (ELF) electromagnetic fields and the development of acute myeloid leukaemia (AML) in adults. At present there is no experimental evidence for such an association. We have investigated the acute effects of power frequency magnetic fields on haemopoiesis in CBA/H mice known to be susceptible to the induction of AML after exposure to ionizing radiation. Up to 19 days after exposure to 50 Hz fields at 20 mT for 7 days no significant effects on peripheral blood characteristics were observed. Assays of the bone marrow stem cells and myelomonocytic progenitor cells also failed to reveal significant effects. Our experiments cannot, however, rule out subtle effects on cell population dynamics, and further investigations, including long-term studies, are required to establish the extent to which ELF magnetic fields might affect the haemopoietic system.
authors.affiliation: MRC Radiobiology Unit, Chilton, Oxon, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Lorimore
authors.forename: C I
authors.initials: CI
authors.lastname: Kowalczuk
authors.forename: R D
authors.initials: RD
authors.lastname: Saunders
authors.forename: E G
authors.initials: EG
authors.lastname: Wright
mesh_terms: D000818:Animals; D004574:Electromagnetic Fields; D006400:Hematocrit; D006410:Hematopoiesis; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA