title: Postnatal ontogeny of gamma glutamyltranspeptidase activity of pancreas in essential fatty acid deficient rats treated with nitrosomethylurea.
abstract: The effect of essential fatty acid deficiency and nitrosomethylurea treatment on postnatal levels of pancreatic gamma-glutamyltranspeptidase was studied. A significant increase of gamma-glutamyltranspeptidase activity and changes in fatty acid composition were observed in essential fatty acid deficient rats, from the 14th day of life on. Pancreatic gamma-glutamyltranspeptidase of nitrosomethylurea injected rats in essential fatty acid deficiency and controls was significantly diminished at the 30th day, with no significant differences in both nutritional conditions. The results indicated: 1. Concomitant changes in gamma-glutamyltranspeptidase activity and fatty acid composition of rat pancreas in essential fatty acid deficiency, 2. A significant reduction of pancreatic gamma-glutamyltranspeptidase activity following a single intraperitoneal injection of nitrosomethylurea at day one of life and 3. No interacting effects of essential fatty acid deficiency and nitrosomethylurea on gamma-glutamyltranspeptidase activity of rat pancreas.
authors.affiliation: Instituto de Biología Celular, Córdoba University Medical School, Argentina.
authors.forename: M A
authors.initials: MA
authors.lastname: Valentich
authors.forename: B
authors.initials: B
authors.lastname: Monis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004032:Diet; D005227:Fatty Acids / Q000032:analysis; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology*; D010179:Pancreas / Q000737:chemistry / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008770:Methylnitrosourea; D005723:gamma-Glutamyltransferase