The low-incidence red cell antigen Wra: genetic studies.
Studies of 91 individuals in three families allowed a genetic-linkage analysis of the gene governing the production of the low-incidence red cell antigen Wra and provided evidence that Wra is not a member of the Scianna, Landsteiner-Wiener, Chido/Rodgers, or XK blood group systems, and that the "WR" locus is excluded from autosomal sites or regions 1p34-p22.1, 1p21-q23, 1q32, 2p25, 3q21, 4q28-q32, 6p24-q12, 9q34.1-q34.2, 13q14.1-q14.2, 14q24.3-q32.1, 14q32.33, 16p13, 16q22.1, and 21q21-q22.1. "WR" is also excluded from within specified genetic distances of chromosomes 8 (GPT), 18 (JK), 19 (C3), 20 (ADA), and 22 (P1) loci, which brings its exclusion to approximately 10 percent (320cM) of the total genetic map of the genome. The possibility that "WR" is pseudoautosomal is deemed to be highly unlikely.
Lewis
M
M
Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
Kaita
H
H
Philipps
S
S
McAlpine
P J
PJ
D001789:Blood Group Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D008126:Lod Score; D008297:Male; D011995:Recombination, Genetic
D001789:Blood Group Antigens; D007519:Isoantigens