trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Holladay
M W
MW
Neuroscience Research Division, Abbott Laboratories, Abbott Park, Illinois 60064.
Lin
C W
CW
May
C S
CS
Garvey
D S
DS
Witte
D G
DG
Miller
T R
TR
Wolfram
C A
CA
Nadzan
A M
AM
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D006168:Guinea Pigs; D006909:Hydroxyproline; D007202:Indicators and Reagents; D008715:Methionine; D015394:Molecular Structure; D010179:Pancreas / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011949:Receptors, Cholecystokinin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013758:Tetragastrin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D007202:Indicators and Reagents; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C067196:3-propylproline; C067195:3-allylproline; D011392:Proline; D008715:Methionine; D006909:Hydroxyproline