title: Chronic administration of H2-antagonists does not alter gastric secretory responses to histamine, or the antisecretory activity of sufotidine.
abstract: Gastric secretory responses to histamine were investigated in anaesthetized dogs following treatment with oral ranitidine at 5 mg/kg twice daily for 358 weeks, and in isolated gastric mucosae from mice receiving sufotidine 240-280 mg.kg/day for 15 months. In neither study were there any significant differences between the acid secretory dose-response curves to histamine in control and test animals. The antisecretory activity of oral sufotidine (1 mg/kg) against histamine-induced acid secretion in the Heidenhain pouch dog was unaltered by twice daily dosing with sufotidine for 14 days. These studies on the effects of H2-antagonists on histamine-stimulated acid secretion found no evidence for development of direct tolerance at the parietal H2-receptor level.
authors.affiliation: Gastrointestinal Pharmacology Department, Glaxo Group Research Ltd., Ware, Hertfordshire, UK.
authors.forename: R
authors.initials: R
authors.lastname: Stables
authors.forename: J M
authors.initials: JM
authors.lastname: Humphray
authors.forename: J J
authors.initials: JJ
authors.lastname: Reeves
mesh_terms: D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010880:Piperidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D006635:Histamine H2 Antagonists; D010880:Piperidines; D014230:Triazoles; C062101:sufotidine; D006632:Histamine