title: Psychopathology in drug abusers and their families.
abstract: Demographic, clinical, and family pedigree data obtained on 350 hospitalized drug-dependent patients showed that 52% also met DSM-III criteria for alcohol abuse or dependence, while 37% met DSM-III criteria for a concurrent axis I psychiatric disorder other than substance abuse. Cyclothymic disorder was significantly more common among cocaine abusers, while generalized anxiety disorder and panic disorder were more common among sedative-hypnotic abusers. Data on 1,478 first-degree relatives revealed that the prevalence of alcoholism and affective disorder was highly correlated with the occurrence of similar psychopathology in the probands. These findings suggest a relationship between drug of choice and comorbid psychopathology, a role for familial factors in the transmission of these disorders, and the importance of diagnostic subtypes in the evaluation and treatment of substance abusers.
authors.affiliation: Department of Psychiatry, McLean Hospital, Belmont, MA 02178.
authors.forename: S M
authors.initials: SM
authors.lastname: Mirin
authors.forename: R D
authors.initials: RD
authors.lastname: Weiss
authors.forename: M L
authors.initials: ML
authors.lastname: Griffin
authors.forename: J L
authors.initials: JL
authors.lastname: Michael
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics / Q000523:psychology*; D001008:Anxiety Disorders / Q000235:genetics / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology*; D003042:Cocaine; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D019964:Mood Disorders / Q000235:genetics / Q000523:psychology; D009293:Opioid-Related Disorders / Q000235:genetics / Q000523:psychology / Q000534:rehabilitation; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000235:genetics / Q000523:psychology* / Q000534:rehabilitation
chemical_list: D006993:Hypnotics and Sedatives; D003042:Cocaine