Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays.
Human lymphocytes exposed to 0.02 Gy of X-rays in the G1 but not the G0 phase became less susceptible to the induction of chromosome aberrations of the chromosome type by subsequent exposure to 3 Gy of X-rays. The induction of chromatid-type aberrations was not affected by the pretreatment with the priming dose. The expression of this adaptive-type response was transitory, being maximum at 5 h, and disappeared at 9 h after the initial low-dose exposure. Cell-cycle analysis excluded the possibility of a spurious consequence of differential cell-cycle progression.
Wang
Z Q
ZQ
Radiation Biology Center, Kyoto University, Japan.
Saigusa
S
S
Sasaki
M S
MS
D000222:Adaptation, Physiological / Q000528:radiation effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004260:DNA Repair; D016193:G1 Phase / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D016192:Resting Phase, Cell Cycle / Q000528:radiation effects; D012854:Sister Chromatid Exchange / Q000528:radiation effects; D013997:Time Factors; D014965:X-Rays