title: Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
abstract: Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.
authors.affiliation: Neurobiology Department, N.E. Ohio Universities College of Medicine, Rootstown 44272.
authors.forename: L M
authors.initials: LM
authors.lastname: Grover
authors.forename: T J
authors.initials: TJ
authors.lastname: Teyler
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009473:Neuronal Plasticity / Q000187:drug effects*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D015763:2-Amino-5-phosphonovalerate; D002118:Calcium