Induction of tolerance to syngeneic IgE in neonatal mice.
We have previously shown that adult A/J mice are tolerant to syngeneic IgE at the level of T cells, but not B cells. T cells of mice are responsive until the age of 2 to 3 wk, which correlates with the time of appearance of serum IgE. Tolerance can be induced earlier by neonatal administration of IgE in saline. We report here that purified nonimmune adult B cells, but not T cells, can transfer the state of tolerance to neonatal mice. As few as 2 x 10(6) B cells are effective. If IgE-bearing or IgE-secreting cells prove to be responsible, the amount of cell-bound IgE that can induce tolerance must be very small. The results also indicate that suppressor T cells do not have a major role in maintenance of self-tolerance to IgE.
Haba
S
S
Department of Biology, Brandeis University, Waltham, MA 02254.
Nisonoff
A
A
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000502:physiology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000276:immunology*; D016219:Immunotherapy, Adoptive; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D007073:Immunoglobulin E