Effect of cefatrizine and cephaloglycine on L-leucine absorption in rat jejunum.
1. The oral cephalosporins: cefatrizine and cephaloglycine inhibit the L-leucine absorption in vivo on rat jejunum. 2. This inhibition is dose and time dependent and the effect is irreversible. 3. These antibiotics have a systemic effect on L-leucine absorption. 4. The inhibition of these antibiotics affect only leucine transport, without affecting the diffusion. 5. Cefatrizine and cephaloglycine inhibit the basolateral (Na(+)-K+) ATPase activity in rat jejunum.
Mendizabal
M V
MV
Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, España.
Idoate
I
I
Larralde
J
J
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002436:Cefatrizine / Q000494:pharmacology*; D002507:Cephaloglycin / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects
D002436:Cefatrizine; D000254:Sodium-Potassium-Exchanging ATPase; D007930:Leucine; D002507:Cephaloglycin