1,25-Dihydroxyvitamin D3 decreases the interferon-gamma (IFN-gamma) induced HLA-DR expression but not intercellular adhesion molecule 1 (ICAM-1) on human keratinocytes.
In human epidermal keratinocytes (HKC), it is known that interferon gamma (IFN-gamma) induces Major Histocompatibility Complex (MHC) class II antigens and intercellular adhesion molecule 1 (ICAM-1) expression. 1,25 (OH)2D3, the most active metabolite of vitamin D3, has been shown to be produced by keratinocytes (KC). KC possess receptors for 1,25 (OH)2D3 and could be a target of 1,25 (OH)2D3. Although immunological participation of 1,25 (OH)2D3 has been reported, little is known about its effect on MHC class II Ag expression or ICAM-1 expression. In this article, we investigate the effect of 1,25 (OH)2D3 on IFN-gamma induced MHC class II Ag or ICAM-1 expression of HKC and reveal that 1,25 (OH)2D3 decreases the IFN-gamma induced HLA-DR, but not ICAM-1 expression on HKC.
Tamaki
K
K
Department of Dermatology, Yamanashi Medical College, Japan.
Saitoh
A
A
Kubota
Y
Y
D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000378:metabolism; D002117:Calcitriol / Q000494:pharmacology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D006682:HLA-DP Antigens / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015603:Keratinocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D011994:Recombinant Proteins
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma; D002117:Calcitriol