title: Liver transplantation in Langerhans' cell histiocytosis (histiocytosis X).
abstract: Two children with biopsy-proven LCH underwent successful hepatic transplantation for end-stage liver disease. These patients were thought not to have active LCH disease at the time of transplantation, although one had developed a new osteolytic lesion a few months before the operation and the other had suspicious osteolytic lesions at the time of transplantation. The histologic examination of the excised liver showed features consistent with primary sclerosing cholangitis. The two patients had an excellent recovery with no evidence of progression of LCH or recurrence of the underlying disease in the hepatic allograft at 1 and 3 years after organ transplantation.
authors.affiliation: Division of Transplantation, Pacific Presbyterian Medical Center, San Francisco, CA 94115.
authors.forename: W
authors.initials: W
authors.lastname: Concepcion
authors.forename: C O
authors.initials: CO
authors.lastname: Esquivel
authors.forename: A
authors.initials: A
authors.lastname: Terry
authors.forename: P
authors.initials: P
authors.lastname: Nakazato
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Kennedy
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: K L
authors.initials: KL
authors.lastname: Cox
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation