Homeostatic regulation of zinc absorption and endogenous losses in zinc-deprived men.
The mechanisms involved in the homeostatic regulation of zinc were studied in five male subjects by using stable 70Zn as a marker. When dietary zinc was reduced from 85 to 12 mumol/d, adaptation was achieved by a mean (+/- SEM) reduction in urine zinc of 48 +/- 7% and in fecal zinc of 46 +/- 12% over 25 d in four subjects. The latter was caused by an increase in the efficiency of zinc absorption from 38 +/- 3% to 93 +/- 1% after 15 d of zinic deprivation and by a reduction in intestinal endogenous losses of zinc. In a fifth subject, who had some evidence of a resolving alcohol-induced hepatitis, urine and fecal zinc were reduced by 64% and 41%, respectively, in 15 d and zinc absorption increased from 46% to 93%. More information on adaptive responses is needed to enable current dietary recommendations to be reconsidered.
Taylor
C M
CM
Rowett Research Institute, Bucksburn, Scotland, UK.
Bacon
J R
JR
Aggett
P J
PJ
Bremner
I
I
D000042:Absorption; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001835:Body Weight; D004032:Diet; D002149:Energy Intake; D006706:Homeostasis; D006801:Humans; D008297:Male; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000469:Alkaline Phosphatase; D015032:Zinc