Methsuximide for intractable childhood seizures.
Methsuximide was added to the therapeutic regimens of 25 children with intractable epilepsy. In 15 patients the drug was well tolerated and resulted in a 50% or greater reduction in seizure frequency. No serious or irreversible adverse effects were seen. Methsuximide is frequently overlooked and may be an effective adjunctive antiepileptic for children with intractable seizures.
Tennison
M B
MB
Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill 27599-7025.
Greenwood
R S
RS
Miles
M V
MV
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010672:Phenytoin / Q000097:blood / Q000627:therapeutic use; D013388:Succinimides / Q000097:blood / Q000627:therapeutic use*
D000927:Anticonvulsants; D013388:Succinimides; C100286:methsuximide; C018504:N-desmethylmethsuximide; D002220:Carbamazepine; D010672:Phenytoin