Linkage studies and deletion screening in choroideremia.
Fourteen families with choroideremia (TCD) have been examined for linkage to nine genetic markers located on the proximal long arm of the X chromosome. Linkage to three markers (DXYS1, DXS72, DXS3) located in Xq21 was found with a four point lod score of 8.25. No evidence of submicroscopic deletions was observed using DXS233 and DXS232, both thought to lie within about 1 Mb of the TCD gene.
Wright
A F
AF
MRC Human Genetics Unit, Western General Hospital, Edinburgh.
Nussbaum
R L
RL
Bhattacharya
S S
SS
Jay
M
M
Lesko
J G
JG
Evans
H J
HJ
Jay
B
B
D015794:Choroideremia / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D015342:DNA Probes; D005260:Female; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D015342:DNA Probes