Radioactive uptake of [14C]histamine by certain tissues in guinea-pigs treated and untreated with chlorpromazine.
1. Oral administration of [14C]histamine induced the presence of small amounts of [14C]histamine in stomach and ileal tissues of control guinea-pigs. In contrast, much larger amounts were found after 8 h infusion. 2. Similar amounts of [14C]histamine were found in the tissues when [14C]histamine was given by intravenous infusion from 24-30 h after chlorpromazine injection.
Ridzwan
B H
BH
Department of Biology, Faculty of Science and Natural Resources, Universiti Kebangsaan Malaysia, Sabah.
Waton
N G
NG
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D002746:Chlorpromazine / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D013270:Stomach / Q000187:drug effects
D002250:Carbon Radioisotopes; D006632:Histamine; D002746:Chlorpromazine