Genetic mapping of the gene for Ca2+/calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18.
Southern blot analysis of Chinese hamster x mouse somatic cell hybrids was used to map the gene for a serine/threonine protein kinase expressed in brain and testis. This locus, termed Camk-4, encodes Ca2+/calmodulin-dependent protein kinase IV. Progeny of an interspecific backcross were analyzed to position Camk-4 in the centromeric region of chromosome 18 near two mutations known to affect neurological function and fertility. This raises the possibility that a defect in Camk-4 may be responsible for one of these mutant phenotypes.
Sikela
J M
JM
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
Adamson
M C
MC
Wilson-Shaw
D
D
Kozak
C A
CA
D000818:Animals; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D005796:Genes; D005819:Genetic Markers; D006822:Hybrid Cells; D007246:Infertility / Q000235:genetics; D008297:Male; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics; D008818:Mice, Neurologic Mutants / Q000235:genetics; D005810:Multigene Family; D009115:Muridae / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011493:Protein Kinase C / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics* / Q000502:physiology; D011995:Recombination, Genetic; D013045:Species Specificity
D005819:Genetic Markers; D011494:Protein Kinases; D011493:Protein Kinase C; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C517685:Camk4 protein, mouse