title: [Paralytic ileus as an initial manifestation of malignant VIPoma of the pancreas--case report with review of the literature].
abstract: A 57-year old patient with a paralytic ileus of unknown origin was admitted to the intensive care unit. Because of the laboratory findings with therapy resistant hypokalemia, hypercalcemia and metabolic acidosis a VIPoma was suspected. Therapy with somatostatin resulted in correction of laboratory abnormalities and in normalization of gastrointestinal motility. Plasma concentrations of VIP and PP were elevated, ultrasonography revealed a pancreatic tumor. Postsurgical examination of the removal tumor tissue confirmed the diagnosis of a malignant VIPoma. Clinical symptoms, laboratory findings with and without somatostatin-therapy and immunhistochemical properties are described.
authors.affiliation: Medizinische Universitätsklinik Essen.
authors.forename: B
authors.initials: B
authors.lastname: Koberstein
authors.forename: V E
authors.initials: VE
authors.lastname: Eysselein
authors.forename: K
authors.initials: K
authors.lastname: Balzer
authors.forename: M K
authors.initials: MK
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Eberlein
authors.forename: M V
authors.initials: MV
authors.lastname: Singer
authors.forename: S
authors.initials: S
authors.lastname: Willemer
authors.forename: G
authors.initials: G
authors.lastname: Adler
authors.forename: H
authors.initials: H
authors.lastname: Goebell
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis; D007262:Infusions, Intravenous; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010186:Pancreatic Function Tests; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013004:Somatostatin / Q000008:administration & dosage; D003969:Vipoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D013004:Somatostatin