[The thrombocyte link in the hemostasis of patients with hemorrhagic fever with renal syndrome].
Altogether 38 patients (33 men and 5 women) suffering from grave and moderate hemorrhagic fever with nephrotic syndrome (HFNS) were examined. The hemolysate aggregation test and ADP were employed to explore the aggregation ability of platelets in those patients. Besides, measurements were made of the activity of the 3rd platelet factor in the plasma and serotonin content in each platelet. A considerable rise of the aggregation activity of platelets was established to take place in the oligoanuric and polyuric periods of HFNS. At the same time the increase in the blood of the 3rd platelet factor and lowering of serotonin in each platelet were noted. The role of platelet hyperaggregation in the pathogenesis of HFNS is discussed. The conclusion is made that such patients were in a prethrombotic state in the oligoanuric and to a lesser degree in the polyuric periods.
Davidovich
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D000208:Acute Disease; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003289:Convalescence; D005260:Female; D006476:Orthohantavirus; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000150:complications; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000097:blood / Q000209:etiology; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D011141:Polyuria / Q000097:blood / Q000209:etiology