[The characteristics of the action of ethacizine and its combination with digoxin and glutamic acid on the hemodynamic indices and myocardial contractile capacity in patients with a heart rhythm disorder].
A study was made of the effect of ethacizine administered in a single dose and continuously on myocardial contractility and hemodynamics in 78 patients with coronary heart disease, neurocirculatory dystonia and myocardiodystrophy suffering from impaired cardiac rhythm. In 28 patients, ethacizine was administered in combination with glutamic acid and in 23 with digoxin. In patients with coronary heart disease, particularly in those with heart failure, ethacizine produced a negative inotropic effect. Introduction into the treatment of digoxin or glutamic acid smoothed over the cardiodepressive action of the drug. When administered continuously in a dose of 150-300 mg/day, ethacizine is an effective antiarrhythmic drug.
Zapevina
V V
VV
Poliakova
L A
LA
Nikolaeva
S A
SA
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D004077:Digoxin / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005971:Glutamates / Q000627:therapeutic use*; D018698:Glutamic Acid; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010640:Phenothiazines / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D005971:Glutamates; D010640:Phenothiazines; D018698:Glutamic Acid; D004077:Digoxin; C046818:ethacizine