Vasoactive intestinal polypeptide loses its ability to increase vaginal blood flow after menopause.
The effect of vasoactive intestinal polypeptide on vaginal blood flow was investigated in postmenopausal women. In women who were receiving hormonal replacement therapy the vasodilatory response induced by vasoactive intestinal polypeptide was identical to that of young women, whereas in postmenopausal women who were receiving no replacement therapy, the response induced by vasoactive intestinal polypeptide was absent. Plasma levels of vasoactive intestinal polypeptide and systemic cardiovascular effects were identical in the two groups.
Palle
C
C
Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark.
Bredkjaer
H E
HE
Fahrenkrug
J
J
Ottesen
B
B
D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D045166:Estradiol Congeners / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D011372:Progestins / Q000627:therapeutic use; D011674:Pulse / Q000187:drug effects / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014621:Vagina / Q000098:blood supply* / Q000187:drug effects; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D045166:Estradiol Congeners; D011372:Progestins; D014660:Vasoactive Intestinal Peptide