title: Cerebral blood flow patterns at major vessel bifurcations and aneurysms in rats.
abstract: Cerebral arterial bifurcations in rats were treated to induce cerebral aneurysms experimentally, and flow patterns of latex particles introduced under a constant flow rate were analyzed with a 16-mm cine-camera and videocassette recorder. Cerebral aneurysms were produced by ligating one common carotid artery, inducing experimental hypertension, and feeding the animals beta-aminopropionitrile. After perfusion and fixation, samples of cerebral arterial bifurcations with shallow invaginations and with small aneurysms were obtained and used for analysis. Bifurcations in rats without experimental treatment were used as control specimens. Flow studies in the control bifurcations showed that the apical intimal pad, not the apex itself, acted as the flow divider. Small particles tended to accumulate at the region just distal to the apical intimal pad, where the initial aneurysmal changes are known to occur. This indicates stagnation of flow at that site. In the bifurcations with shallow invaginations and small aneurysms, a marked pressure gradient was present at the proximal end of the aneurysm orifice. A tendency for stagnation of small particles near the aneurysm wall was also observed. The wall shear stress was highest at the distal end of the aneurysmal orifice, which may be responsible for the development of these lesions.
authors.affiliation: Department of Neurosurgery, Kyoto University Medical School and Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakatani
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kang
authors.forename: N
authors.initials: N
authors.lastname: Yamazoe
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Niimi
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008297:Male; D008863:Microspheres; D009040:Motion Pictures; D051381:Rats; D011919:Rats, Inbred Strains; D012212:Rheology / Q000295:instrumentation; D014743:Videotape Recording