Effects of pancreastatin on pancreatic hormone secretion in the dog.
In the anaesthetized dog, porcine pancreastatin (98 pmol/min) was infused for 10 min into the pancreaticoduodenal artery either alone or during infusion of glucose. Blood was sampled from the pancreaticoduodenal vein. We found that pancreastatin inhibited pancreatic insulin output only under normoglycaemic conditions. Furthermore, pancreastatin significantly stimulated pancreatic glucagon and somatostatin outputs both during normo- and hyperglycaemic conditions. Our results show that pancreastatin has the capability to affect directly the three pancreatic hormone secretions in dogs.
Ribes
G
G
Faculté de Médecine, Laboratoire de Pharmacologie, URA 599 du CNRS, Institut de Biologie, Montpellier, France.
Vecina
F
F
Hillaire-Buys
D
D
Ahren
B
B
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D053379:Chromogranin A; D004285:Dogs; D004386:Duodenum / Q000098:blood supply; D005934:Glucagon / Q000097:blood; D007003:Hypoglycemia / Q000188:drug therapy / Q000378:metabolism; D007328:Insulin / Q000097:blood; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects*; D010187:Pancreatic Hormones / Q000378:metabolism* / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013004:Somatostatin / Q000097:blood
D001786:Blood Glucose; D053379:Chromogranin A; D007328:Insulin; D010187:Pancreatic Hormones; C050836:pancreastatin; D013004:Somatostatin; D005934:Glucagon