Sympathetic neural contribution to salt-induced hypertension in Dahl rats.
The Dahl strain provides a model for examining mechanisms involved in the genetic sensitivity or resistance to salt-induced hypertension. Dahl salt-sensitive rats develop hypertension when fed a high salt diet; Dahl salt-resistant rats remain normotensive. Based on early experiments, it was thought that hypertension in Dahl salt-sensitive rats epitomized the overriding importance of renal and humoral mechanisms in salt-induced hypertension, but studies in the past 15 years have demonstrated that alterations in sympathetic neural mechanisms also participate critically in the genetic predisposition to salt-induced hypertension in Dahl salt-sensitive rats. This article briefly reviews sympathetic neural mechanisms in Dahl rats, including evidence for a role of afferent baroreceptor as well as central neural and peripheral adrenergic mechanisms in salt-induced hypertension in Dahl salt-sensitive rats.
Mark
A L
AL
Department of Internal Medicine, University of Iowa College of Medicine, Veterans Administration Medical Center, Iowa City.
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology; D011311:Pressoreceptors / Q000503:physiopathology; D051381:Rats; D011922:Rats, Mutant Strains / Q000502:physiology*; D012965:Sodium Chloride; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D012965:Sodium Chloride