title: Limited resection for Stage I lung cancer.
abstract: We have reviewed our experience of limited resections for Stage I lung cancer for the years 1971-88. Sixty-one cases of sublobar resection (wedge or segmental) were compared with 411 lobar resections (lobectomies or bilobectomies), performed over the same period. Operative mortality was 0% in the limited resection group and 3% (12/411) in the control group. Cancer recurrence was detected respectively in 36% and 38% of patients, and actuarial survival at 5 years was 55% versus 49% overall. Sublobar resection had a slightly better outcome than lobar resection in pathological T1 (5-year survival of 73% vs 55%) but a worse outcome in pT2 (35% vs 46%); however, none of the differences was statistically significant. In 28 patients with pre-existing cardiac or pulmonary co-morbidity, limited resection yielded the same 5-year survival as lobectomy (53% vs 51%) with no peri-operative deaths (0 vs 5%). Although derived from a retrospective analysis, these data offer a further confirmation that limited resection combined with adequate nodal staging is a reliable and effective technique for early stage lung cancer management.
authors.affiliation: Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Pastorino
authors.forename: M
authors.initials: M
authors.lastname: Valente
authors.forename: V
authors.initials: V
authors.lastname: Bedini
authors.forename: M
authors.initials: M
authors.lastname: Infante
authors.forename: L
authors.initials: L
authors.lastname: Tavecchio
authors.forename: G
authors.initials: G
authors.lastname: Ravasi
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate