The antigen processing pathway in B lymphocytes.
Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.
Watts
C
C
Department of Biochemistry, University of Dundee, UK.
Reid
P A
PA
West
M A
MA
Davidson
H W
HW
D000941:Antigens / Q000378:metabolism*; D000943:Antigens, Differentiation / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D002451:Cell Compartmentation / Q000276:immunology; D002460:Cell Line; D004705:Endocytosis / Q000276:immunology; D011992:Endosomes / Q000276:immunology; D006681:HLA-D Antigens / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism; D017452:Receptors, IgG
D000941:Antigens; D000943:Antigens, Differentiation; D006681:HLA-D Antigens; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG