[Beta-adrenergic reactivity in patients with myocardial infarct according to the antihemolytic test].
Propranolol antihemolytic test parameters calculated with the Hill mathematical model from dose-dependent curves of saturation were studied in 27 patients with myocardial infarction. Erythrocyte beta-adrenoreceptors showed higher sensitivity to propranolol in patients with myocardial infarction within 3 days of the disease. Three weeks after therapy, changes were found in the erythrocyte membranes solely in patients receiving beta-adrenoblockers. The changes are indicative of lower sensitivity of beta-adrenoreceptors to the beta-blocker. Persons with varying responses to propranolol were detected among the patients with myocardial infarction, which may be used to define indications for beta-adrenoblocker therapy.
Sominskiĭ
V N
VN
Anshelevich
Iu V
IuV
Okun'
K V
KV
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D011433:Propranolol; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol