Aloe vera as a biologically active vehicle for hydrocortisone acetate.
Aloe vera, as a biological vehicle for hydrocortisone 21-acetate, was tested topically and systemically against acute inflammation. Systemically, the combination of A. vera and hydrocortisone produced a maximum 88.1% inhibition of edema. Polymorphonuclear leukocyte infiltration was reduced 91.1%. The topical inhibition of edema peaked at 97%. The possibility that A. vera has significant potential as a biologically active vehicle for steroids is discussed.
Davis
R H
RH
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Parker
W L
WL
Murdoch
D P
DP
D000208:Acute Disease; D000287:Administration, Topical; D000504:Aloe; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D014677:Pharmaceutical Vehicles; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D014677:Pharmaceutical Vehicles; C021650:hydrocortisone acetate; D006854:Hydrocortisone