title: A pattern recognition study of acyclic ureide anticonvulsants.
abstract: A pattern recognition structure-activity study employing topological, geometric and physicochemical descriptors was performed on 27 acyclic ureide anticonvulsants. Twelve numerical descriptors were used as variables in a discriminant function analysis which categorized the ureide analogues with respect to their bioactivity. The results from the discriminant function analysis were interpreted to support a model for antiepileptic activity.
authors.affiliation: Department of Chemistry, Queen's University, Kingston, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Khalil
authors.forename: D F
authors.initials: DF
authors.lastname: Weaver
mesh_terms: D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010363:Pattern Recognition, Automated; D013329:Structure-Activity Relationship; D009626:Terminology as Topic; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D014508:Urea