title: A comparison of teicoplanin vs. cephradine and metronidazole in surgical prophylaxis: an interim analysis.
abstract: The preliminary results of a trial to examine and compare the safety, tolerability and efficacy of a single dose of teicoplanin with three doses of cephradine combined with metronidazole are presented in a series of 113 patients undergoing elective vascular surgery. There were no obvious differences in the infection rates and sepsis indicators in either group. Neither drug regimen produced any evidence of renal or hepatic damage, though the levels of three hepatocellular enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl-transferase (GGT), were seen to be transiently elevated, peaking 7 days post-operatively. The trial continues.
authors.affiliation: Department of Vascular Surgery, St. James's University Hospital, Leeds, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Antrum
authors.forename: K
authors.initials: K
authors.lastname: Gorst
authors.forename: K
authors.initials: K
authors.lastname: Galvin
authors.forename: C
authors.initials: C
authors.lastname: Thornton
authors.forename: K
authors.initials: K
authors.lastname: Wynne
authors.forename: C
authors.initials: C
authors.lastname: Malata
authors.forename: C
authors.initials: C
authors.lastname: Ramsden
authors.forename: R
authors.initials: R
authors.lastname: Kester
authors.forename: I
authors.initials: I
authors.lastname: Harding
mesh_terms: D000285:Administration, Rectal; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001424:Bacterial Infections / Q000517:prevention & control*; D002515:Cephradine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004361:Drug Tolerance; D006020:Glycopeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011292:Premedication; D016037:Single-Blind Method; D013530:Surgical Wound Infection / Q000517:prevention & control; D017334:Teicoplanin; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D006020:Glycopeptides; D008795:Metronidazole; D017334:Teicoplanin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002515:Cephradine