Potential value of serology for diagnosis of extrapulmonary tuberculosis.
The possible benefits for improved diagnosis of extrapulmonary tuberculosis were evaluated by means of a modified serological competition assay. Antibodies to the 38 kD Mycobacterium tuberculosis antigen were detected in 73% of cases of extrapulmonary tuberculosis and 70% of smear-negative cases of pulmonary tuberculosis at a chosen specificity of 98%. Of 55 patients (45%) whose diagnosis of tuberculosis was not made until 7 days or longer after admission, 76% were positive for the antibody. In this group the serological test would have allowed chemotherapy to be started on average 12.5 days earlier and would have obviated the need for 80% of diagnostic biopsies.
Wilkins
E G
EG
Department of Infectious Diseases, Lister Unit, Northwick Park Hospital, Harrow, Middlesex, UK.
Ivanyi
J
J
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000995:Antitubercular Agents / Q000627:therapeutic use; D003951:Diagnostic Errors; D005069:Evaluation Studies as Topic; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011237:Predictive Value of Tests; D012698:Serologic Tests / Q000379:methods; D013997:Time Factors; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000995:Antitubercular Agents