Antimetastatic effects of liposome entrapped indomethacin.
The "in vivo"administration of sized liposomes encapsulating indomethacin to mice bearing 3LL tumor, significantly reduced the incidence and/or number of superficial lung metastases. Also liposomes encapsulating indomethacin had significant inhibitory effects on the experimentally induced lung metastases. We conclude: i) indomethacin encapsulated in liposomes is more efficient than the free drug in mediating the antimetastatic effects and ii) liposomes are an valuable vehicle in evading the side metastatic effects of this drug during indomethacin treatment of tumor bearing mice.
Aliño
S F
SF
Departamento de Biología Celular y Ciencias Mofrológicas, Facultad de Medicina y Odontología, Universidad del País Vasco/Euskal Herriko Univertsitatea (UPV/EHU), Vizcaya, Spain.
Iruarrizaga
A
A
Alfaro
J
J
Almena
A
A
Lejarreta
M
M
Unda
F J
FJ
D000818:Animals; D004337:Drug Carriers; D004355:Drug Stability; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D008081:Liposomes; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D004337:Drug Carriers; D008081:Liposomes; D007213:Indomethacin