Biochemical modifications induced by Timorom in the liver carbohydrate metabolism of male and female rats.
A 90-day Timorom treatment of rats of both sexes modified some of the carbohydrate metabolism parameters. Some of the modifications were different in male and female rats. Glycogen storage was increased, while liver GPa activity was decreased in the male rats, but those modifications ran in the opposite direction in the female rats. In our opinion, these different reactions of male and female rats to Timorom (containing a nonselective beta-adrenergic blocking agent--timolol) depended on the different ways by which the glycogen phosphorylase system is activated. Many of the biochemical modifications, obtained after the Timorom treatment, disappeared at the end of the first post-treatment month.
Coprean
D
D
Biological Research Institute, Cluj-Napoca, Romania.
Giurgea
R
R
Puica
C
C
Coprean
D
D
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010762:Phosphorylase a / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D013999:Timolol / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D008112:Liver Glycogen; C074966:Timorom; D013999:Timolol; D010762:Phosphorylase a; D005952:Glucose-6-Phosphatase