Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis.
This study investigated the expression of intercellular adhesion molecule-1 (ICAM-1; CD54) by cells of the central nervous system (CNS) during acute experimental allergic encephalomyelitis (EAE) and chronic relapsing EAE (CREAE). In the CNS of normal guinea pigs, only a few endothelial cells expressed detectable levels of ICAM-1, whereas during the active phases of the disease ICAM-1 was present on cells of the perivascular infiltrate and the endothelia of both lesion- and non-lesion-associated blood vessels. In addition, cultured cerebrovascular endothelia maintained in 'standard' culture medium did not express ICAM-1, but they could be induced to express this antigen on incubation in a lymphocyte-conditioned medium. These findings suggest that the induction of ICAM-1 on CNS endothelia may be important in antigen presentation or in promoting lymphocyte extravasation across the blood-brain barrier in inflammatory disorders of the CNS.
Wilcox
C E
CE
Department of Pathology, Hunterian Institute, Royal College of Surgeons of England, London, U.K.
Ward
A M
AM
Evans
A
A
Baker
D
D
Rothlein
R
R
Turk
J L
JL
D000818:Animals; D015703:Antigens, CD / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D002478:Cells, Cultured; D002490:Central Nervous System / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006168:Guinea Pigs; D018799:Intercellular Adhesion Molecule-1; D008214:Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D005904:Glial Fibrillary Acidic Protein; D018799:Intercellular Adhesion Molecule-1