Monoclonal antibody immunotherapy in nude mice persistently infected with Cryptosporidium parvum.
Three groups of congenitally athymic nude mice were persistently infected following oral administration of 2 x 10(7) Cryptosporidium parvum oocysts. Two groups were treated once daily for 10 days with either neutralizing monoclonal antibody (MAb) 17.41 or an isotype control MAb. The third group received no treatment. Intestinal-infection scores were significantly decreased in nude mice treated with MAb 17.41 compared with isotype control MAb-treated and nontreated control groups (P less than 0.005). Biliary and pancreatic cryptosporidial-infection scores were similar for the MAb 17.41-treated and isotype control MAb-treated groups (P greater than 0.05).
Bjorneby
J M
JM
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Hunsaker
B D
BD
Riggs
M W
MW
Perryman
L E
LE
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000913:Antibodies, Protozoan / Q000627:therapeutic use*; D000953:Antigens, Protozoan / Q000276:immunology; D015153:Blotting, Western; D003135:Common Bile Duct / Q000469:parasitology; D003457:Cryptosporidiosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D007167:Immunotherapy; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology / Q000628:therapy*; D007422:Intestines / Q000469:parasitology; D051379:Mice; D008819:Mice, Nude
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan