title: Malignant transformation of condyloma acuminatum: report of a case.
abstract: Condyloma acuminatum is a benign warty lesion, whose malignant change is rarely seen. A 69-year-old woman with a large vulvar condyloma acuminatum, which she had had for about 14 years, underwent a vulvectomy, and a malignant component to the lesion was found unexpectedly. The continuity from a benign to a malignant lesion was evident in the histopathologic examination. Infection with human papillomavirus type 6 was documented by DNA hybridization. The use of a one-step reverse dot blot hybridization with nonisotope DNA probe in this case was convenient and is recommended.
authors.affiliation: Department of Obstetrics and Gynecology, Pathology, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: D Y
authors.initials: DY
authors.lastname: Chang
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsieh
authors.forename: H C
authors.initials: HC
authors.lastname: Hsieh
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic; D003218:Condylomata Acuminata / Q000473:pathology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D014846:Vulvar Neoplasms / Q000473:pathology*
chemical_list: D004279:DNA, Viral