title: Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats.
abstract: Old F-344 rats were given endurance training over a 10-week period on a motorized treadmill. This treatment resulted in substantial heart-to-body weight ratio increases, indicative of effective training. To determine whether endurance training might alter some of the known immune system and cognitive changes observed during aging, exercised old rats were compared to nonexercised old and young controls on three variables: in vivo antigen-specific immune activity, brain-reactive antibody formation, and spatial memory. The exercise training did not influence any of these measures in the old rats. Both groups of old rats showed poorer antibody response to a specific antigen, more brain-reactive antibody formation, and poorer spatial memory than the young controls. There was, however, a significant relationship between brain-reactive antibody formation and spatial memory performance, regardless of training condition.
authors.affiliation: Department of Psychology, University of Colorado, Boulder 80309.
authors.forename: C A
authors.initials: CA
authors.lastname: Barnes
authors.forename: M J
authors.initials: MJ
authors.lastname: Forster
authors.forename: M
authors.initials: M
authors.lastname: Fleshner
authors.forename: E N
authors.initials: EN
authors.lastname: Ahanotu
authors.forename: M L
authors.initials: ML
authors.lastname: Laudenslager
authors.forename: R S
authors.initials: RS
authors.lastname: Mazzeo
authors.forename: S F
authors.initials: SF
authors.lastname: Maier
authors.forename: H
authors.initials: H
authors.lastname: Lal
mesh_terms: D000375:Aging / Q000276:immunology / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology*; D001921:Brain / Q000276:immunology*; D006433:Hemocyanins / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008568:Memory / Q000502:physiology*; D010805:Physical Conditioning, Animal; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin