Linkage analysis of the murine Hyal-1 locus on chromosome 9.
We have recently described a new locus, Hyal-1, which determines hyaluronidase variants in mouse serum. On the basis of segregation in recombinant inbred and congenic strains, Hyal-1 was tentatively assigned to chromosome 9 (Fiszer-Szafarz and De Maeyer, '89). In the present study we have performed a linkage analysis of Hyal-1 using 156 backcross progeny of an interspecies cross of laboratory mice and Mus Spretus. Linkage was tested to two anchor loci on chromosome 9: d (dilute, a coat color locus) and Bgl-s (a locus controlling beta-galactosidase activity). The gene order (from centromere) with intervening percentage recombination is d-16.6 (+/- 2.9)-Hyal-1-10.9 (+/- 2.4)-Bgl-s, indicating close linkage to H-7 and Fv-2.
De Maeyer-Guignard
J
J
CNRS URA 1343, Institut Curie-Biologie, Centre Universitaire, Orsay, France.
Cachard-Thomas
A
A
De Maeyer
E
E
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006821:Hyaluronoglucosaminidase / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA
D006821:Hyaluronoglucosaminidase