Macromolecular creatine kinase type 1: a serum marker associated with disease.
The prevalence of circulating macromolecular creatine kinase type 1 (macro CK type 1 or CK-immunoglobulin complexes) is significantly higher in a patient population selected for CK isoenzyme assay than in age- and sex-matched blood donors (n = 1304). In greater than 8000 patients studied, 49 individuals with macro CK type 1 were identified, yielding an overall prevalence of 0.61%. Macro CK type 1 complexes occurred more frequently in women and in patients older than 70 years, and were often associated with complications of cardiovascular disease, life-threatening conditions, and poor outcome. These latter clinical associations could arise, at least partly, from the selection of patients for whom CK isoenzyme analysis was ordered.
Laureys
M
M
Department of Clinical Chemistry, Akademisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
Sion
J P
JP
Slabbynck
H
H
Steenssens
L
L
Cobbaert
C
C
Derde
M P
MP
Gorus
F K
FK
D000328:Adult; D000367:Age Factors; D000368:Aged; D001782:Blood Donors; D002318:Cardiovascular Diseases / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D007527:Isoenzymes; D003402:Creatine Kinase