title: Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients.
abstract: Nucleotide sequences were determined from the env genes of three HTLV-I clones derived from two North American patients and one African patient with adult T-cell leukemia/lymphoma (ATLL). In addition, sequences from the pX region, between env and the 3'LTR, were determined from one of these isolates. These data were compared to sequences derived from HTLV-I isolates of two Japanese ATLL patients, a Japanese patient with HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP) and a Caribbean ATLL patient. Nucleotide sequence variation was found to be less than 6% in coding and noncoding regions. Predicted amino acid sequences varied between 0.6 and 1.8% in the envelope, 0-3.7% in rex, 0.8-2.5% in the tax gene product, and 3-14.0% in the pX-I open reading frame. Comparisons of the predicted amino acid sequences of the surface envelope protein (SU-gp46) suggest that the variation between isolates of different geographical origins is greater than that between isolates obtained from the same region of the world.
authors.affiliation: Department of Medicine, Washington University, St. Louis, Missouri 63110.
authors.forename: E
authors.initials: E
authors.lastname: Paine
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: T C
authors.initials: TC
authors.lastname: Philpott
authors.forename: G
authors.initials: G
authors.lastname: Shaw
authors.forename: L
authors.initials: L
authors.lastname: Ratner
mesh_terms: D000349:Africa / Q000208:ethnology; D000595:Amino Acid Sequence; D001483:Base Sequence; D015686:Gene Products, env / Q000235:genetics*; D016356:Gene Products, tax / Q000235:genetics; D005814:Genes, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000382:microbiology*; D008969:Molecular Sequence Data; D009656:North America / Q000208:ethnology; D011110:Polymorphism, Genetic; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D015686:Gene Products, env; D016356:Gene Products, tax; D015678:Viral Structural Proteins