Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients.
Three male patients are described in whom anorgasmia developed during treatment with fluoxetine for depression. During attempts to treat the anorgasmia with cyproheptadine, all three patients suffered a relapse of depressive symptoms. The possible mechanism of this effect is discussed in relation to serotonergic systems.
Feder
R
R
Nashua Brookside Hospital, N.H.
D000328:Adult; D003533:Cyproheptadine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004347:Drug Interactions; D005473:Fluoxetine / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009948:Orgasm / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012008:Recurrence; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000188:drug therapy
D011985:Receptors, Serotonin; D005473:Fluoxetine; D003533:Cyproheptadine