Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization.
Whole-arm translocations in five leukemic patients were studied using nonisotopic in situ hybridization with alpha satellite DNA and simple satellite chromosome-specific DNA probes to detect the target sequences. The results show that this technique provides additional information on the involvement of these DNA sequences in whole-arm translocations.
Speleman
F
F
Department of Medical Genetics, University Hospital, Ghent, Belgium.
Mangelschots
K
K
Vercruyssen
M
M
Dal Cin
P
P
Aventin
A
A
Offner
F
F
Laureys
G
G
Van den Berghe
H
H
Leroy
J
J
D000328:Adult; D000368:Aged; D002503:Centromere; D002648:Child; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004276:DNA, Satellite; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
D015342:DNA Probes; D004273:DNA, Neoplasm; D004276:DNA, Satellite