title: Recovery of circadian rhythm of plasma cortisol levels after a 3-day trip between Tokyo and San Francisco.
abstract: The objective of the present study is to investigate the change in the circadian rhythm of plasma cortisol levels following a 3-d trip and a westbound return flight from San Francisco (SFO) to Tokyo. Six healthy male students volunteered for the project. Plasma cortisol levels were monitored 4 times daily for 13 d during the experimental period. In Tokyo, the baseline pattern of cortisol concentrations showed the classical diurnal profile. During the 50-h stay in SFO, phase advancement of 8 h was observed for the initial 32 h. This was followed by a disturbance in the profile for the remaining 18-h period. After returning to Tokyo, the subjects exhibited the original diurnal pattern beginning Day 1. However, complete resynchronization was not apparent until Day 4 after the return.
authors.affiliation: Flight Crew Medical Service Department, Japan Airlines, Tokyo.
authors.forename: N
authors.initials: N
authors.lastname: Tajima
authors.forename: M
authors.initials: M
authors.lastname: Uematsu
authors.forename: I
authors.initials: I
authors.lastname: Asukata
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Hokari
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000337:Aerospace Medicine; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D012495:San Francisco; D012890:Sleep / Q000502:physiology; D013997:Time Factors; D014041:Tokyo; D014195:Travel; D014851:Wakefulness / Q000502:physiology
chemical_list: D006854:Hydrocortisone