title: Three-dimensional photon treatment planning of the intact breast.
abstract: Three-dimensional treatment planning for the intact breast was performed on two patients who had undergone CT scanning. A total of 38 treatment plans were evaluated. Multiple plans were evaluated for each patient including plans with and without inhomogeneity corrections, plans using varying photon energies of 60Co, 4 MV, 6 MV, 10 MV, and 15 MV, and three-dimensionally unconstrained plans. Increased hot spots were appreciated in the central axis plane when lung inhomogeneity corrections were used. Additional hot spots were appreciated in off-axis planes towards the cephalad and caudad aspects of the target volume because of lung inhomogeneity corrections and changes in the breast contour. The use of 60Co was associated with an increase in the magnitude and volume of hot spots, whereas the use of higher energy photons such as 10 MV and 15 MV was associated with an unacceptable target coverage at shallow depths. Therefore, for the two patients studied, the use of a medium energy photon beam (such as from a 6 MV linear accelerator) appeared to be the energy of choice for treatment of the intact breast. The three-dimensionally unconstrained plans were able to improve slightly upon the standard plans, particularly with relationship of dose to normal tissue structures. Areas for future research were identified, including the use of tissue compensators.
authors.affiliation: University of Pennsylvania School of Medicine, Philadelphia, PA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Solin
authors.forename: J C
authors.initials: JC
authors.lastname: Chu
authors.forename: M R
authors.initials: MR
authors.lastname: Sontag
authors.forename: L
authors.initials: L
authors.lastname: Brewster
authors.forename: E
authors.initials: E
authors.lastname: Cheng
authors.forename: K
authors.initials: K
authors.lastname: Doppke
authors.forename: R E
authors.initials: RE
authors.lastname: Drzymala
authors.forename: M
authors.initials: M
authors.lastname: Hunt
authors.forename: R
authors.initials: R
authors.lastname: Kuske
authors.forename: J M
authors.initials: JM
authors.lastname: Manolis
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted