Control of erythropoietin production.
The cloning and expression of the human erythropoietin gene has not only resulted in an important therapeutic advance but has led to the dissemination of reliable immunoassays and molecular probes for the study of normal and disordered erythropoietin physiology. We are now beginning to understand the cellular and molecular basis for the control of erythropoietin secretion, and have begun to identify abnormal erythropoietin physiology in a wide variety of disease states. This avenue of investigation will continue to expand and should lead to important new therapies for disorders of red blood cell production.
Sytkowski
A J
AJ
Laboratory for Cell and Molecular Biology, New England Deaconess Hospital, Boston, MA 02215.
D000818:Animals; D004921:Erythropoietin / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans
D004921:Erythropoietin