Cardiac output and the blood pressure increase in deoxycorticosterone acetate-salt hypertension after nicotine infusion.
We wished to determine if nicotine exaggerates the blood pressure increase in deoxycorticosterone (DOCA)-salt hypertension. Uninephrectomized, male Sprague-Dawley rats were implanted with DOCA pellets (75 mg) and placed on a 5.2% salt diet for sixteen days and then infused with nicotine (DOCA-Nicotine; 2.4 mg/kg/day) or vehicle (DOCA-Sham). Control animals were treated with vehicle (Control) or nicotine (Control-Nicotine). The DOCA-Nicotine group had significantly greater tail-cuff blood pressures than the DOCA-Sham group by one week of nicotine infusion. At 2.5 weeks of nicotine infusion the DOCA-Nicotine rats had significantly greater tail-cuff blood pressures, direct arterial blood pressures, and cardiac outputs compared to the DOCA-Sham animals. Renal blood flows were similar in the two groups. Control-Nicotine animals demonstrated no response to nicotine during 2.5 weeks of infusion. We conclude that in the DOCA-salt rat nicotine induces an exaggerated rise in blood pressure and that the mechanism involves an increase in cardiac output.
Passmore
J C
JC
Department of Physiology and Biophysics, School of Medicine, University of Louisville, Kentucky 40292.
Jimenez
A E
AE
Pierce
W M
WM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D009538:Nicotine / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D012965:Sodium Chloride; D014655:Vascular Resistance / Q000187:drug effects
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009538:Nicotine