Potassium channel blockers: could they work in Alzheimer disease?
Many of the actions of potassium channel blockers, such as 4-aminopyridine, appear to complement the deficits in Alzheimer disease. The two clinical studies in the literature are contradictory, so potassium channel blockers may still merit trial in Alzheimer disease.
Wiseman
E J
EJ
Department of Psychiatry, University of California, Los Angeles 90024.
Jarvik
L F
LF
D015761:4-Aminopyridine / Q000627:therapeutic use; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D001921:Brain / Q000187:drug effects*; D006801:Humans; D015221:Potassium Channels / Q000187:drug effects*
D015221:Potassium Channels; D015761:4-Aminopyridine