N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery.
This study describes the effects of N omega-hydroxy-L-arginine (NOHA) on endothelium dependent and endothelium independent relaxation of bovine pulmonary artery. These results are consistent with the hypothesis that NOHA is a biosynthetic intermediate in the production of nitric oxide from arginine. N omega-Hydroxy-L-arginine causes both endothelium dependent and endothelium independent vasorelaxation, similar to that of arginine. This NOHA elicited relaxation was also inhibitable by N-methylarginine, N-nitroarginine and N-aminoarginine.
Wallace
G C
GC
Department of Pharmacology, UCLA School of Medicine 90024-1735.
Gulati
P
P
Fukuto
J M
JM
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D004730:Endothelium, Vascular / Q000502:physiology; D066298:In Vitro Techniques; D008751:Methylene Blue / Q000494:pharmacology; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D010108:Oxyhemoglobins / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D010108:Oxyhemoglobins; D014665:Vasodilator Agents; D009569:Nitric Oxide; C068309:N(omega)-hydroxyarginine; D001120:Arginine; D008751:Methylene Blue