title: 99mTc-d,l-HMPAO and SPECT of the brain in normal aging.
abstract: Single photon emission computed tomography (SPECT) with 99mTc-d,l-hexamethylpropyleneamine oxime (99mTc-d,l-HMPAO) was used to determine global and regional CBF in 53 healthy subjects aged 21-83 years. For the whole group, global CBF normalized to the cerebellum was 86.4% +/- 8.4 (SD). The contribution of age, sex, and atrophy to variations in global CBF was studied using stepwise multiple regression analysis. There was a significant negative correlation of global CBF with subjective ratings of cortical atrophy, but not with ratings of ventricular size, Evans ratio, sex, or age. In a subgroup of 33 subjects, in whom volumetric measurements of atrophy were performed, cortical atrophy was the only significant determinant for global CBF, accounting for 27% of its variance. Mean global CBF as measured with the 133Xe inhalation technique and SPECT was 54 +/- 9 ml/100 g/min and did not correlate significantly with age. There was a preferential decline of CBF in the frontal cortex with advancing age. The side-to-side asymmetry of several regions of interest increased with age. A method was described for estimation of subcortical CBF, which decreased with advancing cortical atrophy. The relative area of the subcortical low-flow region increased with age. These results are useful in distinguishing the effects of age and simple atrophy from disease effects, when the 99mTc-d,l-HMPAO method is used.
authors.affiliation: Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Waldemar
authors.forename: S G
authors.initials: SG
authors.lastname: Hasselbalch
authors.forename: A R
authors.initials: AR
authors.lastname: Andersen
authors.forename: F
authors.initials: F
authors.lastname: Delecluse
authors.forename: P
authors.initials: P
authors.lastname: Petersen
authors.forename: A
authors.initials: A
authors.lastname: Johnsen
authors.forename: O B
authors.initials: OB
authors.lastname: Paulson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001284:Atrophy; D001921:Brain / Q000098:blood supply / Q000254:growth & development*; D002531:Cerebellum / Q000098:blood supply; D002540:Cerebral Cortex / Q000473:pathology; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D014980:Xenon Radioisotopes; D019690:Technetium Tc 99m Exametazime