title: Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.
abstract: Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD). This response was reversible after the anesthetic gas was discontinued. Pretreatment with either alpha-adrenergic or beta-adrenergic antagonists (phentolamine or timolol) had no effect on the halothane-induced decrease in SCC. Delivery of the analgestic gas N2O did not alter baseline electrical measurements across the isolated I-CB.
authors.affiliation: Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Tang
authors.forename: T
authors.initials: T
authors.lastname: Krupin
authors.forename: M
authors.initials: M
authors.lastname: Milner
authors.forename: D
authors.initials: D
authors.lastname: Woods
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: D A
authors.initials: DA
authors.lastname: Carré
authors.forename: M M
authors.initials: MM
authors.lastname: Civan
mesh_terms: D000704:Analysis of Variance; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002924:Ciliary Body / Q000502:physiology*; D004737:Enflurane / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D007498:Iris / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D011817:Rabbits
chemical_list: D000777:Anesthetics; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane