Plasma 11-dehydrothromboxane B2: a reliable indicator of platelet hyperfunction in patients with ischemic stroke.
The plasma level of 11-dehydrothromboxane B2 (11-dehydroTXB2) is free from artifactual increase during blood sampling, and it can be reliable indicator of TXA2 production in vivo. We have estimated plasma 11-dehydroTXB2 in patients with ischemic stroke. Subjects studied were 29 patients with cerebral thrombosis (62 +/- 9 years old) and 41 healthy controls (61 +/- 7 years old). Plasma 11-dehydroTXB2 and TXB2 were determined by radioimmunoassay. Plasma 11-dehydroTXB2 levels in patients and controls were 5.4 +/- 2.5 and 1.8 +/- 0.9 pg ml, respectively, and the difference was significant (p less than 0.001). Plasma TXB2 also was higher in patients than in controls: 401 +/- 61 vs 311 +/- 51 pg/ml (p less than 0.05). However, the 11-dehydroTXB2 was found to be a more effective parameter to distinguish between stroke patients and controls. Estimation of plasma 11-dehydroTXB2 levels is a reliable method to detect platelet hyperfunction in stroke patients.
Satoh
K
K
Department of Pathologic Physiology, Hirosaki University, Japan.
Imaizumi
T
T
Yoshida
H
H
Hiramoto
M
M
Konta
A
A
Takamatsu
S
S
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000201:enzymology*; D008875:Middle Aged; D010979:Platelet Function Tests; D013928:Thromboxane A2 / Q000097:blood; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000097:blood
D013929:Thromboxane B2; D013928:Thromboxane A2; C049235:11-dehydro-thromboxane B2