Low concentrations of sodium and magnesium in erythrocytes from cystic fibrosis heterozygotes.
The concentrations of electrolytes and trace elements in erythrocytes were determined in eight children with cystic fibrosis (CF) and the parents of four of the children and compared with age- and sex-matched healthy controls. The children with CF had significantly lower median erythrocyte concentrations of sodium, magnesium and zinc and a higher median concentration of calcium than both the healthy control children and the parents of the CF children. Although the sodium and magnesium median values were higher in CF parents than in CF children they were nevertheless significantly lower than in adult controls. These data indicate a system for heterozygote detection.
Foucard
T
T
Department of Paediatrics, University Hospital, Uppsala, Sweden.
Gebre-Medhin
M
M
Gustavson
K H
KH
Lindh
U
U
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood* / Q000175:diagnosis; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D008297:Male; D012964:Sodium / Q000097:blood*; D015032:Zinc / Q000097:blood
D002712:Chlorides; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D002118:Calcium