Immunohistochemical approach to the study of the cat carotid body.
The mammalian carotid body contains a number of different cell types which are not always easy to identify in routine histological sections. We have devised a battery of immunohistochemical tests which overcome this difficulty and offer the possibility of performing routine morphometric analyses of the response of the organ to various pathological processes in paraffin-embedded sections. The type 1 cells can be identified on the basis of their reaction with neuronal specific enolase, whilst type II cells react with antibodies to S-100 protein. Schwann cells do not react with S-100 antibodies but do so with antibodies to glial fibrillary acidic protein; nerve fibres can be identified by their reaction to neurofibrillary protein.
Abramovici
A
A
Laboratory of Developmental Pathology, Sackler School of Medicine, University of Tel Aviv, Israel.
Pallot
D J
DJ
Polak
J M
JM
D000818:Animals; D001369:Axons / Q000737:chemistry; D002344:Carotid Body / Q000737:chemistry* / Q000166:cytology*; D002415:Cats; D005347:Fibroblasts / Q000737:chemistry; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D012583:Schwann Cells / Q000737:chemistry
D007106:Immune Sera