[Lymphoma of the splenic mantle. Morphologic, immunologic and ultrastructural characterization of a case].
We present a splenic primary mantle lymphoma in a 64 year old woman, without peripheral lymphoadenopathy and stage IV at the moment of the diagnosis. Grossly a splenic infiltration was observed. Microscopically, a nodular lymphoma of small lymphocytes proliferating around benign germinal centers makes the diagnosis. Immunohistochemically, tumoral lymphocytes expressed SIgG/kappa and CD5 (Leu-1). Markers of follicular center origin CD10 (CALLA) were negative. According to working formulation mantle-cell lymphoma is considered a lymphoma of intermediate grade of malignancy. In our case, the morphologic, immunologic, ultrastructural findings and clinical evolution were more characteristics of a low grade lymphoma that a intermediate grade of malignancy.
Sabater Marco
V
V
Servicio de Anatomía Patológica, Hospital General Universitario, Valencia.
Alemany Monraval
P
P
Ferrando Marco
J
J
Salvador Villalba
I
I
Martorell Cebollada
M
M
D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000473:pathology* / Q000648:ultrastructure