title: Improved method for in vivo magnetic resonance contrast media research.
abstract: This paper describes an approach for contrast media research with which high resolution MR images of rats can be studied before, during, and after intravenous contrast media administration. Using a probe designed to hold up to eight rats, the contrast-enhancing properties in normal rat brains of Gd-DTPA, a low molecular weight compound, and polylysine-(Gd-DTPA), a high molecular weight compound, were compared simultaneously in two groups of four rats each. Signal intensity-time graphs, as measured over various anatomical structures of the normal rat head, demonstrated the feasibility of directly comparing enhancement patterns of two pharmacologically different contrast agents and obtaining relevant data in a single experiment.
authors.affiliation: Department of Radiology, University of Washington School of Medicine, Seattle 98195.
authors.forename: U P
authors.initials: UP
authors.lastname: Schmiedl
authors.forename: K R
authors.initials: KR
authors.lastname: Maravilla
authors.forename: J A
authors.initials: JA
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003287:Contrast Media; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011107:Polylysine / Q000031:analogs & derivatives; D051381:Rats
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004369:Pentetic Acid; D019786:Gadolinium DTPA