Altered glucose 1,6-bisphosphate and fructose 2,6-biphosphate levels in low-frequency stimulated rabbit fast-twitch muscle.
Glucose 1,6-bisphosphate (Glc-1,6-P2) and fructose 2,6-bisphosphate (Fru-2,6-P2) concentrations display pronounced increases in rabbit fast-twitch muscle during chronic low-frequency stimulation. These increases are first seen after stimulation periods exceeding 3 h and reach maxima after 12-24 h of stimulation (approximately 3-fold for Glc-1,6-P2 and 5-fold for Fru-2,6-P2). Both metabolites regress to normal values after stimulation periods longer than 4 days. The fact that their increases coincide with the replenishment of glycogen after its initial depletion, could point to a role of Glc-1,6-P2 and Fru-2,6-P2 in glycogen metabolism.
Green
H J
HJ
Fakultät für Biologie, Universität Konstanz, Germany.
Cadefau
J
J
Pette
D
D
D000818:Animals; D004558:Electric Stimulation; D005260:Female; D005635:Fructosediphosphates / Q000378:metabolism*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000378:metabolism*; D011817:Rabbits
D005635:Fructosediphosphates; D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; C027652:fructose 2,6-diphosphate; D006003:Glycogen; C016473:glucose-1,6-bisphosphate