Plasmapheresis in Raynaud's phenomenon in systemic sclerosis: a microcirculatory study.
Microcirculatory and haemorheological parameters were investigated before and after plasmapheresis in eighteen patients with secondary Raynaud's phenomenon based on progressive systemic sclerosis. After 4 plasmaphereses, once a week, all patients claimed explicit improvement of their complaints. Raynaud's phenomenon and especially the reaction upon cold provocation had disappeared and skin ulcers healed. Red blood cell (RBC) velocity increased significantly (p less than 0.001) after 4 weeks plasmapheresis. RBC aggregation and plasma viscosity were significantly lower (p less than 0.001) after the last plasmapheresis than before treatment. After 3 years four patients were still free of complaints, but in 14 patients the symptoms of Raynaud's phenomenon had reappeared after 6 to 9 months. The skin ulcers, however, did not return in these patients. RBC aggregation and plasma viscosity returned to the initial values after 9 months, while skin capillary blood flow remained significantly enhanced for 24 months. The finding that restoration of RBC aggregation and plasma viscosity to normal level is associated with enhanced skin capillary blood flow, indicates that disturbed haemorheology plays a role in the diminished skin blood flow, as observed in patients with secondary Raynaud's phenomenon. In these patients, plasmapheresis can be considered to treat severe ischemia of the digits.
Jacobs
M J
MJ
Department of Surgery, University Hospital Maastricht, The Netherlands.
Jörning
P J
PJ
Van Rhede van der Kloot
E J
EJ
Kitslaar
P J
PJ
Lemmens
H A
HA
Slaaf
D W
DW
Reneman
R S
RS
D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000502:physiology; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011928:Raynaud Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012595:Scleroderma, Systemic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012867:Skin / Q000098:blood supply*