title: 8;20 chromosomal translocation in a case of acute leukemia. Cytogenetic, immunophenotypic, ultrastructural, and molecular characteristics.
abstract: An 8;20 chromosomal translocation was observed in the leukemia cells of a 3-year-old girl. To our knowledge, this is the first report of this translocation in de novo acute leukemia. This chromosomal defect was present in the leukemia cells at diagnosis and also at relapse, but remission bone marrow cells had the 46,XX karyotype. By morphologic and cytochemical criteria the leukemia was myeloid but these features were more lymphoid when the leukemia recurred. However, the immunophenotype was consistent with myeloid leukemia and did not change at relapse. No evidence for either immunoglobulin or TCR gene rearrangement was observed.
authors.affiliation: Pediatric Leukemia Program, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: K F
authors.initials: KF
authors.lastname: Jorgenson
authors.forename: G R
authors.initials: GR
authors.lastname: Antoun
authors.forename: C C
authors.initials: CC
authors.lastname: Childs
authors.forename: E A
authors.initials: EA
authors.lastname: Felix
authors.forename: A
authors.initials: A
authors.lastname: Cork
authors.forename: G
authors.initials: G
authors.lastname: Yee
authors.forename: J M
authors.initials: JM
authors.lastname: Trujillo
authors.forename: D P
authors.initials: DP
authors.lastname: Pinkel
authors.forename: T F
authors.initials: TF
authors.lastname: Zipf
mesh_terms: D014408:Biomarkers, Tumor; D002675:Child, Preschool; D002890:Chromosomes, Human, Pair 20; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005819:Genetic Markers; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers