title: Lymphomatoid granulomatosis. A report of 4 cases.
abstract: Only 1 case of lymphomatoid granulomatosis has previously been reported from South Africa. Experience with 4 such adult patients (2 blacks and 2 whites) is described. These patients were followed up for 15-48 months and none developed evidence of a lymphoma during this period. Fever, weight loss, cough and breathlessness were prominent symptoms in all patients. One patient, a black woman, with a diffuse interstitial pattern of lung involvement, had digital clubbing--a rare accompaniment that resolved after therapy. Dilated congestive cardiomyopathy was found in association with pulmonary nodules in a black male patient. All 4 patients were treated with cytotoxic regimens. The 2 patients treated with oral cyclophosphamide and prednisolone responded favourably. The possible explanation for paucity of reports of lymphomatoid granulomatosis from South Africa could be under-reporting, underdiagnosis or a true geographic/ethnic variation in the incidence of this condition.
authors.affiliation: Department of Medicine, University of Natal, Durban.
authors.forename: U G
authors.initials: UG
authors.lastname: Lalloo
authors.forename: K
authors.initials: K
authors.lastname: Cooper
authors.forename: E M
authors.initials: EM
authors.lastname: Irusen
authors.forename: B T
authors.initials: BT
authors.lastname: le Roux
authors.forename: V B
authors.initials: VB
authors.lastname: Jogessar
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008230:Lymphomatoid Granulomatosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications; D011859:Radiography; D013019:South Africa / Q000453:epidemiology