A case of classical mycosis fungoides associated with human T-cell lymphotropic virus type I.
A 72-year-old male patient from north-eastern Iran developed the typical clinical and histopathological features of mycosis fungoides with lymphadenopathy, but without any other systemic involvement. Human T-cell lymphotropic virus (HTLV-I) antibodies were detected in the patient's serum by two different ELISAs and by Western blot using purified viral particles from MT-2 culture supernatants. Cultured peripheral blood lymphocytes were positive for labelling with anti-HTLV-I serum. Southern blot hybridization of DNA extracted from a skin tumour and from an involved lymph node revealed integrated proviral DNA with identical restriction patterns. This case supports a relationship between mycosis fungoides and HTLV-I and may indicate a new region of endemic HTLV-I infection.
Detmar
M
M
Department of Dermatology, University Medical Center Steglitz, Free University of Berlin, Germany.
Pauli
G
G
Anagnostopoulos
I
I
Wunderlich
U
U
Herbst
H
H
Garbe
C
C
Stein
H
H
Orfanos
C E
CE
D000368:Aged; D015139:Blotting, Southern; D015153:Blotting, Western; D004279:DNA, Viral / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications*; D015368:Human T-lymphotropic virus 1 / Q000032:analysis; D006801:Humans; D007492:Iran; D008198:Lymph Nodes / Q000737:chemistry; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications* / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics; D014764:Viral Proteins / Q000032:analysis
D004279:DNA, Viral; D014764:Viral Proteins