Effects of 7 successive days of unaccustomed prolonged exercise on aerobic performance and tissue damage in fitness joggers.
The effects of 7 successive days of prolonged jogging on aerobic performance and biochemical markers of muscle and red blood cell damage were examined in 10 moderately fit men, ages 27 +/- 2 yr (mean +/- SE). The subjects jogged for 2 h per day at 78 +/- 4% of maximal heart rates and covered a total of 129 +/- 2 km, nearly eight times their regular weekly training distance. At baseline, maximal oxygen uptake (VO2max) during treadmill tests averaged 3.45 +/- 0.24 L/min, or 44.7 +/- 1.4 ml/kg/min. On follow-up tests 2d after the week of increased training, VO2max (3.56 +/- 0.17 L/min) and treadmill performance were not significantly improved. Body weight declined from 79.5 +/- 4.6 kg to 77.8 +/- 4.4 kg (p less than 0.05) because of reduced body fatness (16.8 +/- 2.3% to 13.6 +/- 1.7%, p less than 0.05). Weight-adjusted VO2max increased to 46.4 +/- 2.0 ml/kg/min (p less than 0.05). However, heart rate and systolic blood pressure were not significantly changed at rest, or during submaximal and maximal treadmill exercise. Mean hemoglobin concentration at treadmill testing declined from 14.9 +/- 0.3 g/dl to 13.3 +/- 0.3 g/dl (p less than 0.05). Leg muscle soreness, especially in the thigh region, persisted in all subjects after 3 d. Soreness was accompanied by chronic elevations (p less than 0.05) in serum levels of myoglobin, creatine kinase (CK), lactic dehydrogenase (LD), aminoaspartate, and the isoenzymes CK-MB and LD1,2. Serum haptoglobin levels after jogging fell from 86 +/- 9 mg/dl to 60 +/- 8 mg/dl (p less than 0.05), suggestive of footstrike hemolysis.(ABSTRACT TRUNCATED AT 250 WORDS)
Dressendorfer
R H
RH
Department of Clinical Investigation, Tripler Army Medical Center, Honolulu, Hawaii.
Wade
C E
CE
Claybaugh
J
J
Cucinell
S A
SA
Timmis
G C
GC
D000328:Adult; D000704:Analysis of Variance; D003402:Creatine Kinase / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007590:Jogging; D008297:Male; D009132:Muscles / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D009211:Myoglobin / Q000378:metabolism; D010101:Oxygen Consumption; D010146:Pain / Q000209:etiology; D005082:Physical Exertion / Q000502:physiology*; D013647:Task Performance and Analysis
D006454:Hemoglobins; D009211:Myoglobin; D003402:Creatine Kinase