Diffuse melanosis in metastatic malignant melanoma.
The skin of a patient with diffuse melanosis as a result of malignant melanoma was examined by light microscopy, immunohistochemistry, and electron microscopy. Our findings indicate that the slate-blue discoloration in this patient was due to pigment deposition in dermal macrophages and endothelial cells. Multiple attempts to identify disseminated metastatic melanoma cells were unsuccessful.
Steiner
A
A
Department of Dermatology I, University of Vienna Medical School, Austria.
Rappersberger
K
K
Groh
V
V
Pehamberger
H
H
D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications / Q000556:secondary* / Q000648:ultrastructure; D008548:Melanosis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000150:complications / Q000556:secondary* / Q000648:ultrastructure