Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells.
We have previously reported that inhibition of protein kinase C induces differentiation of neuroblastoma cells in culture. It is shown now that actinomycin D, a well known inhibitor of DNA synthesis, reduces selectively the content of protein kinase C and induces neuritogenesis in Neuro 2a cells in culture.
Miñana
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Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Valencia, Spain.
Felipo
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Grisolía
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D000818:Animals; D002454:Cell Differentiation; D004247:DNA / Q000096:biosynthesis; D003609:Dactinomycin / Q000494:pharmacology*; D051379:Mice; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011493:Protein Kinase C / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D003609:Dactinomycin; D004247:DNA; D011493:Protein Kinase C