Suppressive effect of anti-rheumatic drugs on interleukin-1 beta release from human peripheral blood monocytes.
We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen). Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not. These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release.
Okamoto
M
M
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Sasano
M
M
Goto
M
M
Nishioka
K
K
Aotsuka
S
S
Nakamura
K
K
Yokohari
R
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001310:Auranofin / Q000494:pharmacology; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D007375:Interleukin-1; D001310:Auranofin; D003545:Cysteine; C026535:bucillamine; D007052:Ibuprofen