Glomus tumours of the skin: an immunohistochemical investigation of the expression of marker proteins.
Immunohistochemical studies were carried out on cutaneous glomus tumours from 10 patients. The glomus areas in these tumours reacted strongly with anti-smooth muscle (CGA-7), anti-muscle (HHF-35) and anti-vimentin antibodies. Their neural supply was analysed using several nervous tissue markers (anti-neurone specific enolase, anti-S 100, anti-Leu 7, anti-neurofilaments). The results indicate a sprouting and proliferation rather than entrapment of pre-existing nerve fibres.
Herbst
W M
WM
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Nakayama
K
K
Hornstein
O P
OP
D000199:Actins / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D005925:Glomus Jugulare Tumor / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D009130:Muscle, Smooth / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis*; D009417:Nerve Tissue / Q000378:metabolism; D012878:Skin Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D000199:Actins; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D014746:Vimentin