Cell culture model systems to study HDV expression, replication and pathogenesis.
Due to the transient nature of HDV replication in natural and experimental hosts and to the inability of the virus to replicate in easily handled cell lines, studies of the replication and expression of HDV have been impeded. These difficulties have been overcome by the development of the cell lines described in this paper.
Gowans
E J
EJ
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia.
Macnaughton
T B
TB
Jilbert
A R
AR
Burrell
C J
CJ
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000502:physiology*; D015152:Blotting, Northern; D002460:Cell Line; D003001:Cloning, Molecular; D015967:Gene Expression Regulation, Viral; D003699:Hepatitis D / Q000175:diagnosis / Q000209:etiology; D003698:Hepatitis Delta Virus / Q000235:genetics / Q000502:physiology*; D035923:Hepatitis delta Antigens; D006801:Humans; D008099:Liver / Q000382:microbiology; D002679:Pan troglodytes; D012367:RNA, Viral / Q000096:biosynthesis*; D011863:Radioimmunoassay; D011994:Recombinant Proteins / Q000096:biosynthesis; D014158:Transcription, Genetic; D014779:Virus Replication
D000956:Antigens, Viral; D035923:Hepatitis delta Antigens; D012367:RNA, Viral; D011994:Recombinant Proteins; C442244:hepatitis delta virus large antigen