Solitary fibrous tumor of the pleura. An immunohistochemical, electron microscopic and tissue culture study of a tumor producing insulin-like growth factor I in a patient with hypoglycemia.
We report a patient with recurrent hypoglycemia most likely caused by a solitary fibrous tumor of the pleura. After removal of the tumor, hypoglycemia resolved. The bland histologic picture of this tumor is emphasized. Electron microscopic and immunohistochemical observations support its non-mesothelial derivation. In vitro studies demonstrated that the tumor tissue produced insulin-like growth factor I (IGF-I), and its role as the cause of hypoglycemia is discussed.
Strøm
E H
EH
Department of Pathology, Ullevål Hospital, Oslo, Norway.
Skjørten
F
F
Aarseth
L B
LB
Haug
E
E
D000368:Aged; D005260:Female; D005350:Fibroma; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008654:Mesothelioma; D008854:Microscopy, Electron; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology*; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D007334:Insulin-Like Growth Factor I