title: Sneddon syndrome: cerebral perfusion studies by Tc99m HM-PAO and SPECT.
abstract: Sneddon syndrome is a non-inflammatory, non-atherosclerotic disease involving small and medium-sized arteries of the brain and of the skin. The arteriographic examination is often negative despite progressive impairment of the neurological status. In 3 patients with Sneddon syndrome cerebral perfusion was assessed with single photon emission computerized tomography (SPECT) and technetium99 m-hexamethylpropylenamineoxime (Tc99 HM PAO). A correlation between clinical and SPECT finding was found, with significant focal reduction of regional cerebral blood flow (rCBF) in the two more severely affected patients.
authors.affiliation: Divisione Neurologica, Ospedale Niguarda-Ca Granda, Milano.
authors.forename: C
authors.initials: C
authors.lastname: Canepari
authors.forename: S
authors.initials: S
authors.lastname: Cappa
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: M
authors.initials: M
authors.lastname: Riva
authors.forename: R
authors.initials: R
authors.lastname: Sterzi
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D010477:Perfusion; D012871:Skin Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D013577:Syndrome; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime