title: The pathogenesis of the ovarian hyperstimulation syndrome (OHS): a possible role for ovarian renin.
abstract: Two patients with severe ovarian hyperstimulation syndrome are described. Increased plasma concentrations of immunoradiometrically determined total renin are shown, together with greatly increased plasma levels of active renin and aldosterone. These very high values for total renin, renin activity and aldosterone were not suppressed when extracellular compartments were greatly expanded; the values subsequently declined to normal levels, despite the use of diuretics. This suggested that the renin was of non-renal origin since its production was apparently unaffected by influences which control juxtaglomerular secretion. The high concentrations of the renin-angiotensin-aldosterone system suggest that it contributes to the genesis of the ovarian hyperstimulation syndrome.
authors.affiliation: Cobbold Laboratories, Middlesex Hospital, London, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Ong
authors.forename: V
authors.initials: V
authors.lastname: Eisen
authors.forename: D P
authors.initials: DP
authors.lastname: Rennie
authors.forename: R
authors.initials: R
authors.lastname: Homburg
authors.forename: G C
authors.initials: GC
authors.lastname: Lachelin
authors.forename: H S
authors.initials: HS
authors.lastname: Jacobs
authors.forename: J D
authors.initials: JD
authors.lastname: Slater
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D010049:Ovarian Diseases / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D012083:Renin / Q000097:blood / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013268:Stimulation, Chemical; D013577:Syndrome
chemical_list: D006063:Chorionic Gonadotropin; D000450:Aldosterone; D012083:Renin