The role of transforming growth factor-beta in hematopoiesis. A review.
The role of TGF beta hematopoiesis is currently being defined. It does appear that TGF beta and related polypeptides can modulate and regulate bone marrow and thymic-derived cells throughout their functional life span. The effects of TGF beta are pleiotropic and may depend on (a) cell lineage, (b) specific cellular phenotype, (c) stage of differentiation, (d) immediate microenvironment, (e) other cytokines and (f) cellular function. The understanding of TGF beta and its relationship to other cytokines should not only increase our understanding of hematopoiesis but may also have therapeutic implications.
Hooper
W C
WC
Division of Immunologic, Oncologic, and Hematologic Diseases, Centers for Disease Control, Atlanta, GA 30333.
D002454:Cell Differentiation; D002455:Cell Division; D016207:Cytokines / Q000502:physiology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016207:Cytokines; D006454:Hemoglobins; D016212:Transforming Growth Factor beta