N2-glucuronidation and N4-acetylation of sulphaphenazole by the turtle Pseudemys scripta elegans.
After an oral dose of 100 mg of sulphaphenazole, the turtle Pseudemys scripta elegans excretes 27% of the compound unchanged and 3.8% as N4-acetylsulphaphenazole. The expected glucuronide conjugate, sulphaphenazole-N2-glucuronide, is not formed and excreted.
Vree
T B
TB
Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.
Vree
M L
ML
Benneken Kolmer
N
N
Hekster
Y A
YA
Shimoda
M
M
D000107:Acetylation; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005965:Glucuronates / Q000378:metabolism*; D013426:Sulfaphenazole / Q000378:metabolism / Q000493:pharmacokinetics*; D014426:Turtles / Q000378:metabolism*
D005965:Glucuronates; D013426:Sulfaphenazole