title: Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma.
abstract: A tumor with the light microscopic and immunohistologic characteristics of chordoma in the sacrococcygeal region in a 48-year-old man was examined by electron microscopy and immunohistochemistry for tubulin. A large population of cells exhibited prominent parallel arrays of long, straight microtubules in the rough endoplasmic reticulum in addition to the well-described ultrastructural features of chordoma. Immunoreaction to tubulin recognized in the juxtanuclear regions of the large number of tumor cells was in accordance with the ultrastructural localization of the microtubular aggregates. This seems to be the first report of microtubular aggregations in rough endoplasmic reticulum in classic chordoma. Furthermore, the present electron microscopic and immunohistochemical findings suggest that tubulin is a constituent of the unusual structures.
authors.affiliation: Department of Pathology, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: I
authors.initials: I
authors.lastname: Nakanishi
authors.forename: H
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Tomita
mesh_terms: D000368:Aged; D002817:Chordoma / Q000648:ultrastructure*; D003050:Coccyx; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure*; D008871:Microvilli / Q000648:ultrastructure; D008928:Mitochondria / Q000648:ultrastructure; D012447:Sacrum; D013125:Spinal Neoplasms / Q000648:ultrastructure*; D014404:Tubulin / Q000032:analysis
chemical_list: D014404:Tubulin