[Arthritis from a biochemical aspect].
The dynamic processes of remodeling and cartilage destruction occurring in osteoarthritis are associated with an altered metabolism of the chondrocytes. Two mechanisms can be made responsible for chondrocyte activation: Stimulation by cytokines (mainly interleukin-1) and phenotypic modulation. Remodeling of osteoarthritic joint structures is associated with cell proliferation and neovascularization, while erosion of the articular cartilage is promoted by a variety of endopeptidases of chondrocytic origin. These aspects are briefly reviewed in the light of recent findings.
Baici
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Rheumaklinik und Institut für Physikalische Therapie, Universitätsspital Zürich.
D002358:Cartilage, Articular / Q000201:enzymology / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D010003:Osteoarthritis / Q000378:metabolism*; D010641:Phenotype
D007375:Interleukin-1; D010450:Endopeptidases