title: Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization.
abstract: Whole-arm translocations in five leukemic patients were studied using nonisotopic in situ hybridization with alpha satellite DNA and simple satellite chromosome-specific DNA probes to detect the target sequences. The results show that this technique provides additional information on the involvement of these DNA sequences in whole-arm translocations.
authors.affiliation: Department of Medical Genetics, University Hospital, Ghent, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Speleman
authors.forename: K
authors.initials: K
authors.lastname: Mangelschots
authors.forename: M
authors.initials: M
authors.lastname: Vercruyssen
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: A
authors.initials: A
authors.lastname: Aventin
authors.forename: F
authors.initials: F
authors.lastname: Offner
authors.forename: G
authors.initials: G
authors.lastname: Laureys
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: J
authors.initials: J
authors.lastname: Leroy
mesh_terms: D000328:Adult; D000368:Aged; D002503:Centromere; D002648:Child; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004276:DNA, Satellite; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
chemical_list: D015342:DNA Probes; D004273:DNA, Neoplasm; D004276:DNA, Satellite