Role of non-esterified fatty acids in regulating plasma cholesterol transport.
1. The cholesteryl ester transfer protein (CETP) promotes an equimolar exchange of cholesteryl esters between the high density lipoproteins (HDL) and low density lipoproteins (LDL) in human plasma. 2. Sodium oleate converts this CETP-mediated process of exchange into one of net mass transfer of cholesteryl esters from HDL to LDL. 3. Thus, conditions which increase the concentration of non-esterified fatty acids in plasma may favour the redistribution of cholesterol from the non-atherogenic HDL to the atherogenic LDL fraction.
Barter
P J
PJ
Baker Medical Research Institute, Prahran, Victoria, Australia.
D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006023:Glycoproteins; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D006023:Glycoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL