[Ovulation inhibition with RU 486].
Starting from the theory, that progesterone (P) may be one of the triggers of physiologic ovulation, P receptor blocking agent Mifepristone was administered to 7 regularly menstruating women, 2 days before the expected time of ovulation. Ovulation was monitored by ultrasound folliculometry and determination of serum estradiol (E2), P and luteinizing hormone (LH) levels. The luteal phase was checked by measuring urinary pregnandiol glucuronide excretion. Administration of the drug was properly timed in 5 cases, none of the existing follicles ruptured, one got luteinized and 4 had undergone atresia. According to these findings P seems to be a trigger of ovulatory events.
Zalányi
S
S
Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Németh
G
G
D003276:Contraceptives, Oral / Q000494:pharmacology*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors
D003276:Contraceptives, Oral; D011980:Receptors, Progesterone; D015735:Mifepristone