Protein folding: construction of functional structure.
The problem of protein folding was studied with trypsin inhibitor by deviation analysis (1). The results showed that: i) Qualitatively, the main features of the structure, determined by this method, coincided with the structure determined by X-ray crystallography (3). This structure is, however, not topological but functional, and may elucidate the functional relations between various parts of the protein.
Kiho
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Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Shiga-ken, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D014644:Genetic Variation; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010179:Pancreas / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D014361:Trypsin Inhibitors / Q000737:chemistry* / Q000378:metabolism
D010446:Peptide Fragments; D014361:Trypsin Inhibitors