Genomic changes on the short arm of human chromosome 1 in breast cancer.
A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.
Mars
W M
WM
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston.
Genuardi
M
M
Tsihira
H
H
Anderson
D E
DE
Saunders
G F
GF
D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm