[Hepatitis B and D recurrence after liver transplantation].
In Italy, many patients with B-virus (HBV) and Delta-virus (HDV) end-stage liver disease, are potential candidates to liver transplantation. Several authors have reported 70 to 100% hepatitis recurrence rates. From june 1983 to may 1989, 72 transplants on 60 patients were performed at Liver Transplantation Department of the Maggiore-Policlinico Hospital of Milan. The results in 26 HBsAg positive patients (19 with HDV infection), that underwent liver transplantation, are reported. A detailed report of 17 of these patients with a follow-up longer 7 months, and the clinical course of 4 patients with HBV reinfection, 3 of which had hepatitis recurrence, is also presented. The occurrence of HDV-RNA in the serum of 5 patients, that were negative for HBsAg and also other HBV-HDV replication markers after transplantation is discussed, together with the observation that in these patients no hepatitis recurrences or alteration of the clinical course were evident.
Grendele
M
M
Ospedale Maggiore Policlinico, Milano.
Colledan
M
M
Doglia
M
M
Fassati
L R
LR
Ferla
G
G
Gridelli
B
B
Maggi
U
U
Reggiani
P
P
Rossi
G
G
Caccamo
L
L
D015415:Biomarkers / Q000097:blood; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000453:epidemiology* / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D003699:Hepatitis D / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D007558:Italy / Q000453:epidemiology; D016031:Liver Transplantation; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D012008:Recurrence; D012086:Reoperation; D014761:Viral Hepatitis Vaccines / Q000276:immunology
D015415:Biomarkers; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D014761:Viral Hepatitis Vaccines