Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia.
We examined the ultrastructure of subpial beta/A4 amyloid deposits in the brains of patients with Alzheimer-type dementia. A few amyloid fibrils were found between thick astroglial processes (glia limitans). We also examined the ultrastructural localization of beta/A4 protein by the indirect immunoperoxidase technique. Electron-dense immunoreactive products scattered sporadically in the subpial areas were observed between astroglial processes. The labeling was fibrillar and/or amorphous. Subpial beta/A4 deposition may occur between astroglial processes as amorphous pre-amyloid and amyloid fibrils.
Yamaguchi
H
H
College of Medical Care and Technology, Gunma University, Japan.
Nakazato
Y
Y
Yamazaki
T
T
Shoji
M
M
Kawarabayashi
T
T
Hirai
S
S
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism* / Q000648:ultrastructure; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D016253:Microscopy, Immunoelectron
D016229:Amyloid beta-Peptides