[Cytoplasmic immunoglobulins in chronic B-lymphoid leukemia].
Chronic lymphocytic leukemia B-cells (B-CLL cells) have surface immunoglobulin (Smlg). In addition, cytoplasmic immunoglobulins (Clg) have been reported in chronic lymphocytic leukemia B-cells and are useful for ascertaining monoclonality of the disease. In a study of 60 cases of chronic lymphocytic leukemia B-cells, surface immunoglobulin determinations alone demonstrated monoclonality in 38% of cases, versus 65% of cases with combined surface immunoglobulin and cytoplasmic immunoglobulins determinations. Membrane markers were studied using a panel of monoclonal antibodies. Thirty-six per cent of patients were positive for CD 10. No correlations were seen between immunologic markers and clinical stage.
Filippi
J F
JF
Laboratoire d'Hématologie Biologique, Faculté de Médecine et de Pharmacie, Marseille, France.
Nicolino-Brunet
C
C
Tubiana
N
N
Carcassonne
Y
Y
Sampol
J
J
D001402:B-Lymphocytes / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell