Vancomycin-resistant Corynebacterium species causing prosthetic valve endocarditis successfully treated with imipenem and ciprofloxacin.
Endocarditis caused by a Corynebacterium sp. resistant to vancomycin, penicillin G, erythromycin, gentamicin and rifampicin arose in a 44-year-old woman 4 months after replacement of the mitral valve with a prosthesis. She was successfully treated with a 79-day course of intravenous imipenem and ciprofloxacin and replacement of the prosthesis 48 days after treatment began.
Barnass
S
S
Department of Medical Microbiology, St Bartholomew's Hospital, West Smithfield, London, U.K.
Holland
K
K
Tabaqchali
S
S
D000328:Adult; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003352:Corynebacterium / Q000187:drug effects; D003354:Corynebacterium Infections / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D008943:Mitral Valve; D013045:Species Specificity; D014640:Vancomycin / Q000494:pharmacology
D002939:Ciprofloxacin; D014640:Vancomycin; D015378:Imipenem