L-669,262, a potent HMG-CoA reductase inhibitor.
The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.
Joshua
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H
Merck Sharp & Dohme Research Laboratories, Inc., Rahway, NJ 07065.
Schwartz
M S
MS
Wilson
K E
KE
D000818:Animals; D005285:Fermentation; D006900:Hydroxylation; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009615:Nocardia / Q000378:metabolism*; D051381:Rats; D019821:Simvastatin; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C068819:L 669262; D008148:Lovastatin; D019821:Simvastatin