title: Noradrenaline release from the rat heart during anoxia: effects of changes in extracellular sodium concentration and inhibition of sodium uptake mechanisms.
abstract: 1. Anoxic perfusion of the isolated rat heart releases noradrenaline in the absence of sympathetic nerve fibre stimulation. 2. Anoxic noradrenaline release is enhanced by reducing the extracellular Na+ concentration, consistent with the proposal that such release occurs by carrier-mediated efflux. 3. Release is also enhanced by lignocaine but inhibited by amiloride and ethylisopropylamiloride, suggesting that sodium entry into adrenergic nerve terminals during anoxia occurs by Na+/H+ (and possibly Na+/Ca2+) exchange.
authors.affiliation: Department of Medicine, University of Edinburgh, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Dart
authors.forename: R A
authors.initials: RA
authors.lastname: Riemersma
mesh_terms: D000584:Amiloride / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D005110:Extracellular Space / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
chemical_list: D000584:Amiloride; D008012:Lidocaine; D012964:Sodium; C039614:ethylisopropylamiloride; D009638:Norepinephrine