title: Evolution of the MIP family of integral membrane transport proteins.
abstract: Six integral membrane proteins of bacterial, animal, and plant origin, which are believed to function in solute transport, share sequence identity and are grouped together as members of the MIP family. These include the Escherichia coli glycerol facilitator, the major intrinsic protein from bovine lens fibre junction membranes, a plant tonoplast membrane protein, a soybean protein from the peribacteroid membrane, and a Drosophila neurogenic protein. These proteins, each of which appears to consist of six transmembrane helical segments per subunit, apparently arose by internal duplication of a three-transmembrane segment. Phylogenetic 'trees' interrelating these proteins and segments are presented.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093-0116.
authors.forename: G M
authors.initials: GM
authors.lastname: Pao
authors.forename: L F
authors.initials: LF
authors.lastname: Wu
authors.forename: K D
authors.initials: KD
authors.lastname: Johnson
authors.forename: H
authors.initials: H
authors.lastname: Höfte
authors.forename: M J
authors.initials: MJ
authors.lastname: Chrispeels
authors.forename: G
authors.initials: G
authors.lastname: Sweet
authors.forename: N N
authors.initials: NN
authors.lastname: Sandal
authors.forename: M H
authors.initials: MH
authors.lastname: Saier
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry; D005075:Biological Evolution; D002352:Carrier Proteins / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D010940:Plant Proteins