title: Ontogenesis of the depressant activity of carbachol on synaptic activity in rat visual cortex.
abstract: We studied the ontogeny of muscarinic depression in the developing rat visual cortex using carbachol (a nonhydrolyzable cholinergic agonist) application to neocortical slices obtained from four postnatal age groups: 9-10 days, 15 days, 30-40 days and 18 months. Carbachol suppressed the evoked synaptic response of layers II-III to stimulation of layer II-III afferents. Atropine eliminated the carbachol effect, suggesting that it is mediated by muscarinic receptors. The results indicate a significant increase in muscarinic efficacy in the developing rat visual cortex.
authors.affiliation: Northeastern Ohio College of Medicine, Neurobiology Department, Rootstown 44272.
authors.forename: G
authors.initials: G
authors.lastname: Vaknin
authors.forename: T J
authors.initials: TJ
authors.lastname: Teyler
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
chemical_list: D011976:Receptors, Muscarinic; D002217:Carbachol