Reduced levels of calcitonin gene-related peptide-like immunoreactivity in human brain vessels after subarachnoid haemorrhage.
Human cerebral vessels were found to contain calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI) which in the reversed phase HPLC co-eluted with authentic human alpha-CGRP. The level was significantly lower in arteries removed from patients who had died from a subarachnoid haemorrhage (SAH) as compared to patients who died of a coronary infarction. On a molar basis human alpha-CGRP was more potent than human beta-CGRP to dilate human brain vessels and to dilate vasoconstriction elicited by whole blood. It is suggested that the trigemino-cerebrovascular system storing CGRP-LI may be involved in the pathophysiology of SAH in man.
Edvinsson
L
L
Department of Internal Medicine, University of Lund, Sweden.
Ekman
R
R
Jansen
I
I
McCulloch
J
J
Mortensen
A
A
Uddman
R
R
D000328:Adult; D001808:Blood Vessels / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000378:metabolism*; D002536:Cerebral Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011863:Radioimmunoassay; D013345:Subarachnoid Hemorrhage / Q000378:metabolism*
D015237:Dinoprost; D015740:Calcitonin Gene-Related Peptide