[The carcinogenic and anticarcinogenic properties of neozon D].
Continuous administration of neozone D to dogs and rats failed to reveal its carcinogenicity. Nor did the agent potentiate the carcinogenic effect of 2-naphthylamine and benzidine in rats. Conversely, neozone D was found to inhibit benzidine-induced carcinogenesis in female rats.
Pliss
G B
GB
Vlasov
N N
NN
Zabezhinskiĭ
M A
MA
D015081:2-Naphthylamine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001560:Benzidines; D002273:Carcinogens / Q000633:toxicity*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D013997:Time Factors
D000970:Antineoplastic Agents; D001560:Benzidines; D002273:Carcinogens; C029876:benzidine; C011948:neozone; D015081:2-Naphthylamine