title: Determination of the anatomical size of ventricular septal defects on the basis of hemodynamic data and noninvasive assessment of pulmonary to systemic vascular resistance ratio Rp/Rs by Doppler-echocardiography.
abstract: The pulmonary and systemic flow (Qp/Qs) and resistance ratios (RP/Rs) were determined in children with isolated ventricular septal defects (VSD) to derive an "effective defect resistance" (Rd/Rs) representing the ratios of the resistance of the defect to the systemic vascular resistance. The defect size (expressed as the ratio of the area of the defect to the cross-sectional area of the ascending aorta) was related to the calculated "effective defect resistance," where a significant (non-linear) correlation was found. The effective resistance of the defect is a useful aid for estimation of the anatomical size of a ventricular septal defect. The close correlation between anatomical size and the hemodynamic parameter Rd/Rs allows one to calculate the ratio Rp/Rs with this concept using noninvasive Doppler-ultrasound and echocardiography. This was performed in 21 children with VSD who underwent cardiac catheterisation. The noninvasive calculated flow ratio Qp/Qs and the resistance ratio Rp/Rs showed a close correlation to the values measured at cardiac catheterisation.
authors.affiliation: Department of Paediatric Cardiology, Children's Hospital, University Erlangen-Nuernberg, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Rupprecht
authors.forename: M
authors.initials: M
authors.lastname: Hofbeck
authors.forename: H
authors.initials: H
authors.lastname: Singer
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: K H
authors.initials: KH
authors.lastname: Deeg
authors.forename: L
authors.initials: L
authors.lastname: Benson
mesh_terms: D006328:Cardiac Catheterization; D015150:Echocardiography, Doppler; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging* / Q000473:pathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D008955:Models, Cardiovascular; D011652:Pulmonary Circulation / Q000502:physiology; D012044:Regression Analysis; D014655:Vascular Resistance / Q000502:physiology