title: Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
abstract: The modifying effect of the experimentally induced liver cirrhosis on the diethylnitrosamine (DENA)-hepatocarcino-genesis was investigated in male Fischer 344 rats. Cirrhosis was produced by either repeated intragastric doses of CCl4 for 3 months or by simultaneous administration of CCl4 and phenobarbital (PB) in drinking water for 6 weeks. The hepatocarcinogenic regimen consisted of multiple ip. administrations of DENA (10 mg/kg b.w. per dose, up to a total dose of 200 mg/kg b.w.). All the animals were killed 8 months after starting the experiment. The chronic CCl4-post-treatment exerted a strong promoting effect, while the established cirrhosis completely prevented the formation of hepatocellular carcinomas.
authors.affiliation: 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Zalatnai
authors.forename: I
authors.initials: I
authors.lastname: Sárosi
authors.forename: A
authors.initials: A
authors.lastname: Rot
authors.forename: K
authors.initials: K
authors.lastname: Lapis
authors.forename: K
authors.initials: K
authors.lastname: Lapsis
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D004052:Diethylnitrosamine; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000150:complications / Q000503:physiopathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010634:Phenobarbital / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D004052:Diethylnitrosamine; D002251:Carbon Tetrachloride; D010634:Phenobarbital