Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects.
The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.
Oga
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Departamento de Farmacologia do Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Taniguchi
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SF
Najjar
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R
Souza
A R
AR
D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D004487:Edema / Q000188:drug therapy*; D005480:Flurbiprofen / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000502:physiology*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared
D000894:Anti-Inflammatory Agents, Non-Steroidal; C068597:copper flurbiprofen complex; D005480:Flurbiprofen