title: Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.
abstract: The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (Cl-8:1 delta 11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 micrograms/ml, respectively.
authors.affiliation: Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hirotani
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Koshimizu
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
mesh_terms: D000438:Alcohols / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D009829:Oleic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D016354:Rhodobacter capsulatus / Q000032:analysis*; D013604:T-Phages / Q000187:drug effects* / Q000254:growth & development; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000438:Alcohols; D000998:Antiviral Agents; D005227:Fatty Acids; D009829:Oleic Acids; C065593:cis-vaccenic acid