Spontaneous pneumothorax in cystic adenomatoid malformation. Unusual clinical and histologic features.
Pneumothorax is a rare presentation of congenital cystic adenomatoid malformation (CCAM) in the newborn period and is presumed to be due to resuscitative measures. A previously well three-week-old baby presented with spontaneous tension pneumothorax due to CCAM. In the lung resection specimen, a malformation was seen, which in addition to the histologic changes of CCAM, showed diffuse vascular proliferation in the interstitium and lining of air space by type 2 pneumocytes. We propose that this is a new variant of CCAM rather than one of the classic three types. The unusual clinical manifestation may be related to the unusual histologic features.
Bentur
L
L
Division of Chest Medicine, Hospital for Sick Children, Toronto, Canada.
Canny
G
G
Thorner
P
P
Superina
R
R
Babyn
P
P
Levison
H
H
D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008854:Microscopy, Electron; D011030:Pneumothorax / Q000209:etiology*