Digital vascular reactivity in patients on haemodialysis treated with human recombinant erythropoietin.
Digital vascular reactivity was determined in 12 normotensive patients on chronic hemodialysis without a history of Raynaud's phenomenon before and after partial correction of anaemia with human recombinant erythropoietin (rHuEPO): apparent finger systolic pressures and finger skin temperatures were recorded at rest, after local cooling, and following 5 minutes rewarming time. Finger systolic pressures remained constant during the whole test, pre and post rHuEPO therapy. The decrease in finger skin temperatures after cold provocation as well as the rewarming behaviour after cooling were normal in both examinations. The present data indicate that treatment with EPO does not interfere with digital arterial reactivity in normotensive patients on haemodialysis.
Stefenelli
T
T
Department of Cardiology, University of Vienna Medical School, Austria.
Boszotta
A
A
Kaliman
J F
JF
Mayer
G
G
Graf
H
H
D000328:Adult; D000368:Aged; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D006435:Renal Dialysis; D012881:Skin Temperature / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*
D011994:Recombinant Proteins; D004921:Erythropoietin