[Protein content and activity of peptide hydrolases in subcellular fractions of the hypothalamus at various levels of feeding motivation].
After 3-days fasting the specific activity of neutral peptide-hydrolases decreased in the homogenate and nuclear fractions and increased in the mitochondrial and soluble ones. After 5-7-days fasting the above peculiarity persisted. Under the diet recovery specific enzyme activity was recovered up to the control level on the 30th day only. The obtained data prove an intensive renewal of the neutral and acid proteins in the subcellular hypothalamic structures depending on different levels of feeding motivation. This increased functional activity of proteinases is aimed at providing for informational and intracellular processes comprising energetic and structural plasticity of the neuronal organizations of the hypothalamic functional feeding system.
Askerov
F B
FB
Alekperova
S A
SA
Velikhanova
G R
GR
D000818:Animals; D005508:Food Deprivation / Q000502:physiology*; D007031:Hypothalamus / Q000737:chemistry* / Q000201:enzymology; D009042:Motivation; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009473:Neuronal Plasticity / Q000502:physiology; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000737:chemistry* / Q000201:enzymology; D013569:Synapses / Q000502:physiology
D009419:Nerve Tissue Proteins; D010447:Peptide Hydrolases