title: Airway responsiveness in atopic dermatitis.
abstract: Twelve of 123 patients with atopic dermatitis (AD) were screened by questionnaire and spirometry for the absence of smoking, hay fever, and respiratory disorders. Seven of these 12 patients had a positive methacholine challenge test. None of eight patients with another skin disorder, psoriasis, screened in a similar fashion, had a positive methacholine challenge. We conclude that hyperresponsive airways are a frequent finding in patients with AD and that similar mechanisms may account for the cutaneous physiologic and pharmacologic abnormalities that have been observed in AD.
authors.affiliation: Department of Internal Medicine, Oregon Health Services University, Portland.
authors.forename: A F
authors.initials: AF
authors.lastname: Barker
authors.forename: C A
authors.initials: CA
authors.lastname: Hirshman
authors.forename: R
authors.initials: R
authors.lastname: D'Silva
authors.forename: J M
authors.initials: JM
authors.lastname: Hanifin
mesh_terms: D000328:Adult; D000368:Aged; D001985:Bronchial Provocation Tests; D003876:Dermatitis, Atopic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008688:Methacholine Compounds; D008875:Middle Aged; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000503:physiopathology*
chemical_list: D008688:Methacholine Compounds