title: T lymphocytes degrade fibronectin.
abstract: Mononuclear cells cause disappearance of fibronectin synthesized and released by fibroblasts. This disappearance of extracellular fibroblast fibronectin is accompanied by the appearance of components of 'lower' molecular weight indicating that a fibronectin-degrading enzymatic activity is responsible for the effect. Additional support for the existence of a fibronectin-degrading enzyme is that mononuclear cells degrade iodinated fibronectin attached to a collagen matrix. Furthermore, lymphocytes seem to mediate the degradation of fibronectin whereas monocytes rather act inhibitory.
authors.affiliation: Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
authors.forename: S E
authors.initials: SE
authors.lastname: Bergström
authors.forename: D
authors.initials: D
authors.lastname: Hauzenberger
authors.forename: K G
authors.initials: KG
authors.lastname: Sundqvist
mesh_terms: D015153:Blotting, Western; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D005353:Fibronectins