title: A French controlled multicenter study of intraarticular orgotein versus intraarticular corticosteroids in the treatment of knee osteoarthritis: a one-year followup.
abstract: The efficacy of injection of orgotein was compared with that of betamethasone over a one-year period in 419 patients with osteoarthritis of the knee. The criteria for efficacy were the number of recurrences, the rate of persistence in the trial and, secondarily, Lequesne index and the visual analogue scale. Though betamethasone was quicker-acting, the efficacy of orgotein at low doses (4 or 8 mg) was comparable with that of the corticosteroid from Week 4 and up to a year after the beginning of the study, at the cost of a greater number of injections and more numerous local side effects.
authors.affiliation: Department of Rheumatology, Rangueil University Hospital, University Paul Sabatier, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Mazières
authors.forename: A M
authors.initials: AM
authors.lastname: Masquelier
authors.forename: M H
authors.initials: MH
authors.lastname: Capron
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008667:Metalloproteins / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008667:Metalloproteins; C005180:orgotein