Helvecardins A and B, novel glycopeptide antibiotics. II. Structural elucidation.
Helvecardins A and B, which are produced by Pseudonocardia compacta subsp. helvetica, are new members of glycopeptide antibiotics. They contain the same pseudoaglycone as beta-avoparcin and the same compositions of neutral sugar, amino sugar, and amino acid except that 2'-O-methylrhamnose was detected in helvecardins instead of rhamnose in beta-avoparcin, and mannose was not detected in helvecardin B. From these results and 1H NMR and mass spectral analyses, helvecardins A and B were determined beta-avoparcin 2'-O-methylated on rhamnose and demanosylhelvecardin A, respectively.
Takeuchi
M
M
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Takahashi
S
S
Inukai
M
M
Nakamura
T
T
Kinoshita
T
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C068812:helvecardin A; C068813:helvecardin B