Involvement of the short arm of the derivative chromosome 9 in Philadelphia-positive acute lymphoblastic leukemia.
Three Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) patients showed rearrangement of the short arm of the chromosome 9 involved in Ph formation. At diagnosis, blast cells were morphologically L2 and phenotypically B-cell precursors, as shown by common ALL antigen (CALLA), B1, B4 and HLA-DR positivity. Cytogenetically, they had in common the presence of cells with normal karyotypes, the Ph, involvement of band 9p13----p21, and loss of region 9p13----9pter. In our experience, involvement of the p arm of the derivative chromosome 9 in Ph+ leukemias is a very rare event found in ALLs only.
Sessarego
M
M
Cattedrà di Clinica Medica II, Università di Genova, Italy.
Defferrari
R
R
Fugazza
G
G
Comelli
A
A
Salvidio
E
E
Ajmar
F
F
D000328:Adult; D002648:Child; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*