Adrenergic and adrenolytic effects on intraocular pressure.
We compared the pressure-lowering effects of timolol, pindolol, epinephrine and the mixture of timolol and epinephrine with that of placebo over a 12-h period. All agents reduced the pressure significantly but with varying time courses. The mixture of timolol and epinephrine reduced the pressure significantly more than did timolol or epinephrine alone, especially at 12 h after the last administration of the drops.
Drance
S M
SM
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Douglas
G R
GR
Wijsman
K J
KJ
Schulzer
M
M
D000287:Administration, Topical; D000704:Analysis of Variance; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D010869:Pindolol / Q000008:administration & dosage* / Q000494:pharmacology; D010919:Placebos; D013999:Timolol / Q000008:administration & dosage* / Q000494:pharmacology
D010919:Placebos; D013999:Timolol; D010869:Pindolol; D004837:Epinephrine