title: Continuous venous infusion of vinblastine in metastatic breast cancer.
abstract: In 19 patients with advanced pretreated breast cancer, vinblastine was administered by continuous venous infusion (2 mg/m2/24 h for 120 h every 3 weeks), using a totally implanted venous access and a portable pump. A total of 55 courses were given. Five objective responses were observed. Drug-related toxicity consisted mainly of leukopenia (4 patients), fever (4 patients) and nausea and vomiting (3 patients). Catheter-related toxicity was observed in 4 patients (21%) and consisted of infection of the skin pocket in 1 patient and dislodging of the needle with drug extravasation in 3 patients.
authors.affiliation: Istituo Nazionale per la Ricerca sul Cancro, Genova, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Pronzato
authors.forename: P
authors.initials: P
authors.lastname: Queirolo
authors.forename: M G
authors.initials: MG
authors.lastname: Vidili
authors.forename: D
authors.initials: D
authors.lastname: Amoroso
authors.forename: G
authors.initials: G
authors.lastname: Bertelli
authors.forename: M R
authors.initials: MR
authors.lastname: Sertoli
authors.forename: R
authors.initials: R
authors.lastname: Rosso
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014747:Vinblastine