Exercise endurance and fuel utilization: a reevaluation of the effects of fasting.
The effect of fasting on energy utilization during running or swimming was studied in adult male Wistar rats. Compared with fed rats, fasted animals displayed a decreased contribution of carbohydrates in energy supply, with decreased liver and muscle glycogen contents and decreased rate of glycogen breakdown. This was compensated by an enhanced rate of beta-oxidation. In addition, fasting induced an exaggerated sympathoadrenal response during exercise, reflected by a greater epinephrine plasma level and a higher norepinephrine turnover rate in both liver and soleus. Nevertheless, endurance capacity was similar in fasted and fed animals. These results contrast with the impairment of endurance observed in fasting humans but also with the improvement of endurance in rats previously reported by Dohm et al. (J. Appl. Physiol. 55: 830-833, 1983). These data suggest that the metabolic responses to exercise subsequent to food deprivation depend not only on the considered species but also, in the same species (rat), on the age of the animals and the duration of the fast. These factors probably determine the hormonal secretion and substrate utilization during prolonged exercise in fasting conditions.
Koubi
H E
HE
Unite de Recherche Associee, Centre National de la Recherche Scientifique, Faculté de Médecine, Lyon, France.
Desplanches
D
D
Gabrielle
C
C
Cottet-Emard
J M
JM
Sempore
B
B
Favier
R J
RJ
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism; D005215:Fasting / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012420:Running; D013550:Swimming
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D008112:Liver Glycogen; D006003:Glycogen; D009638:Norepinephrine