[The effect of x-ray radiation and hypoxia on the proteolytic activity of the normal rat spleen and during tumor growth].
The influence of X-radiation on activity of lysosomal enzymes (D, L, H cathepsins) in rat spleen tissue and in inoculated rat sarcoma 45 has been investigated. Intact rats and rats with tumors were subjected to whole-body and sarcoma 45 to local irradiation with doses of 0.155 C/kg and 0.31 C/kg in conditions of breathing gas hypoxic mixture containing 90% of nitrogen and 10% of oxygen (GHM-10). The combined exposure to radiation and GHM-10 was shown to produce a certain protective action (e.g. normalized cathepsin activity) in the spleen. In the tumor tissue the protective effect of GHM-10 was absent.
Likholat
E A
EA
Reva
A D
AD
Sokolov
I I
II
Chernaia
V I
VI
D000818:Animals; D000860:Hypoxia / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D009368:Neoplasm Transplantation; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism / Q000528:radiation effects*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000201:enzymology*; D013154:Spleen / Q000201:enzymology / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; C041364:nitrox; D010447:Peptide Hydrolases; D009584:Nitrogen; D010100:Oxygen