Evaluation of acute renal failure with magnetic resonance imaging using gradient-echo and Gd-DTPA.
Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 micrograms/kg/min) into the renal arteries for 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.
Munechika
H
H
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
Sullivan
D C
DC
Hedlund
L W
LW
Beam
C A
CA
Sostman
H D
HD
Herfkens
R J
RJ
Pelc
N J
NJ
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000473:pathology; D000818:Animals; D003287:Contrast Media; D004285:Dogs; D019786:Gadolinium DTPA; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D009942:Organometallic Compounds; D004369:Pentetic Acid; D012079:Renal Circulation
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA