title: [The effectiveness of CDDP in metastatic adenocarcinoma with unknown origin].
abstract: A 28-year-old man with inoperable metastatic adenocarcinoma in the retroperitoneum was referred to our hospital for a further evaluation for its origin. The tumor was measured 80 x 107 mm by abd. U.S. and showed papillary adenocarcinoma, histologically. Chemotherapy with intravenous administration of CDDP at the dose of 80 mg/m2 for 6 times at 2-3 week intervals was started, and CDDP concentration of binding-form and free-form in serum and urine were measured in time course. The tumor has reduced for 29 weeks after the discontinuance of CDDP. Free-CDDP, which was thought to have an anticancerous effect, immediately went up high levels in serum and rapidly excreted to urine, while total-CDDP in serum remained in high concentration for more than 10 weeks. Thus it was suggested that anticancerous effect of CDDP could not be contributed only to free-CDDP and the mechanism of CDDP will be clarified by the elucidation of metabolism of both free and total CDDP, especially in the tumor tissue.
authors.affiliation: Showa University 2nd. Internal Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Mukai
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: A
authors.initials: A
authors.lastname: Nagumo
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Hatta
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D000328:Adult; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009382:Neoplasms, Unknown Primary; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*
chemical_list: D002945:Cisplatin