[Problems of lung transplantation. The state of the mucous membrane of the bronchial tree in acute ischemia of the lung].
The results of the work showed the importance of developing methods for the prevention of ischemic damage to the bronchi and optimal methods for reinforcement of the bronchial suture in lung transplantation. Ischemia may be an important pathogenetic factor of incompetence of the bronchial suture in lung transplantation and may also facilitate disturbance of the transplant's mucociliary clearance with the development of postoperative atelectases, dystelectases, and bronchopneumonia. These data are based on the results of experiments obtained in mongrel dogs by electron microscopy. Prolonged ischemia of the lung (120-180 min) led to mass death of cells of the bronchial endothelium, their rejection from the basement membrane, and desquamation into the bronchial lumen.
Kudriashov
G M
GM
Cherniakova
D N
DN
Kuznetsov
I M
IM
D000208:Acute Disease; D000818:Animals; D001980:Bronchi / Q000473:pathology* / Q000648:ultrastructure; D004285:Dogs; D007511:Ischemia / Q000473:pathology*; D008168:Lung / Q000098:blood supply*; D016040:Lung Transplantation; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000648:ultrastructure