title: [Developmental changes in normal images of 123I-IMP brain SPECT in young children].
abstract: In an attempt to determine the normal evolution of N-isopropyl p-I-123-iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT), we selected 12 children (an age range of 1 month-3 year) who were diagnosed as normal in follow-up between 6 month-3 year by neurological examination, X-ray computed tomography, electroencephalography and 123I-IMP SPECT in our 78 cases. SPECT of the brain was performed 30 minutes after intravenous administration of 74 MBq (2 mCi) 123I-IMP using a rotating gamma camera equipped with a 30-degree slant-hole collimator. In neonates, a predominant activity was observed in the basal ganglia and thalamus, with only slight parietal and occipital activity. Frontal cortex was barely recognizable. Under 1 year, cortical activity was gradually increased and clearly visible. After 1 year, SPECT images were similar to those of adult. In conclusion there was an important modification of the regional perfusion pattern in relation to brain maturation.
authors.affiliation: Department of Radiology, Saitama Medical Center, Saitama Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Takishima
authors.forename: K
authors.initials: K
authors.lastname: Machida
authors.forename: N
authors.initials: N
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Mamiya
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Kamano
authors.forename: S
authors.initials: S
authors.lastname: Tamaki
mesh_terms: D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine