Meningeal involvement in Bence Jones multiple myeloma.
A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64-year-old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.
Oda
K
K
Department of Internal Medicine, Hiroshima City Asa Hospital, Japan.
Egawa
H
H
Okuhara
T
T
Sakai
A
A
Hyohdou
H
H
Tanaka
H
H
Kuramoto
A
A
D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000134:cerebrospinal fluid / Q000150:complications* / Q000473:pathology