title: [An electron microscopic study of migrating cells in the nasal epithelial compartment of human allergic rhinitis].
abstract: Since intraepithelial migrating cells are the first to come into contact with various foreign particles inhaled and deposited on the nasal surface, it is important to study the distribution and function of these cells in the epithelial layer of nasal mucosa. We examined nasal scrapings by means of electron microscopy and electron microscope immunocytochemistry and found that lymphocytes were the major population in the epithelial layer, followed by eosinophils, basophilic cells, globule leukocytes and neutrophils in the order of predominance in patients with allergic rhinitis. However, no significant difference was noted in lymphocyte population between the allergy group and the chronic infectious rhinitis group, while significant increase was found in the normal group than in other two groups. Meanwhile, significant difference of eosinophils and basophilic cells were found between allergic group and non-allergic group. Globule leucocytes, characterized by their huge and irregular size and granules, were observed in the allergy group and the implication of their existence was discussed. In immunoelectron microscopic study, CD8 positive cells were more numerous than CD4 positive cells. However there was no relation between the surface marker and ultrafine structure.
authors.affiliation: Department of Otolaryngorhinology, Nippon Medical School.
authors.forename: C H
authors.initials: CH
authors.lastname: Yen
mesh_terms: D002451:Cell Compartmentation; D002465:Cell Movement / Q000502:physiology; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D016131:Lymphocyte Subsets / Q000648:ultrastructure; D009297:Nasal Mucosa / Q000648:ultrastructure*; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology*