Reversible brain death. A manifestation of amitriptyline overdose.
Tricyclic antidepressants are known to cause central nervous system depression. However, a generalized depression of brainstem functions is rarely reported. We report a patient in deep coma with complete absence of brain-stem reflexes after she had taken a large quantity of amitriptyline. With continuous supportive treatment, she eventually regained all neurologic function and made a full recovery.
Yang
K L
KL
Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, Houston.
Dantzker
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DR
D000639:Amitriptyline / Q000009:adverse effects*; D001926:Brain Death; D003128:Coma / Q000139:chemically induced* / Q000628:therapy; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009460:Neurologic Examination; D013997:Time Factors
D000639:Amitriptyline