title: Transcriptional enhancer in the vicinity of a replication origin within the 5' region of the chicken alpha-globin gene domain.
abstract: A transcriptional enhancer is located near a replication origin within an upstream area of chicken domain of alpha-globin genes. Minimal region possessing enhancer properties is located about 4 kb upstream from the alpha-pi gene. Addition of the neighbouring 500 base-pair DNA fragment, including the constitutive DNase I hypersensitive site, increases the enhancer activity approximately twofold.
authors.affiliation: Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow.
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
authors.forename: Y S
authors.initials: YS
authors.lastname: Vassetzky
authors.forename: A I
authors.initials: AI
authors.lastname: Kvartskhava
authors.forename: N F
authors.initials: NF
authors.lastname: Grinenko
authors.forename: G P
authors.initials: GP
authors.lastname: Georgiev
mesh_terms: D000818:Animals; D001483:Base Sequence; D002645:Chickens; D004261:DNA Replication; D004742:Enhancer Elements, Genetic; D005796:Genes; D005914:Globins / Q000235:genetics*; D008969:Molecular Sequence Data; D014158:Transcription, Genetic
chemical_list: D005914:Globins