[Nonoliguric acute renal failure complicated with tumor lysis syndrome in chronic myelocytic leukemia in lymphoid crisis].
A case of nonoliguric acute renal failure complicated with tumor lysis syndrome is described. The patient is a 14-year-old boy who was diagnosed chronic myelocytic leukemia 17 months ago. On lymphoid crisis, he received vindesine-prednisolone therapy and acute renal failure occurred. Urine output was kept enough volume (2,500-4,000 ml/day), but blood urea nitrogen and serum creatinine levels rose and hyperkalemia, hyperphosphatemia and hypocalcemia were observed. Tumor lysis syndrome in patients with chronic myelocytic leukemia is rare, and acute renal failure with tumor lysis syndrome is oliguric or anuric in most patients. At therapy of lymphoproliferative disease, nonoliguric acute renal failure may occur. Physicians who treat patients with lymphoproliferative disease should pay attention to blood urea nitrogen and serum creatinine levels even if urine output is satisfactory.
Kobayashi
R
R
Department of Pediatrics, Hokkaido University, School of Medicine.
Naito
H
H
Shikano
T
T
Ishikawa
Y
Y
Matsumoto
T
T
Tonooka
T
T
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000652:urine; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001752:Blast Crisis / Q000473:pathology*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D015275:Tumor Lysis Syndrome / Q000209:etiology*; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects
D011239:Prednisolone; D003404:Creatinine; D014751:Vindesine