IgA-containing immune complexes in the circulation of patients with primary Sjögren's syndrome.
IgA-, IgM- and IgG-containing immune complexes (CIC) were detected in 48, 19 and 12% of 52 patients with primary Sjögren's syndrome (SS), in 36, 38 and 56% of 45 patients with rheumatoid arthritis, and in 8, 5 and 3% of 40 normal controls. A high proportion of primary SS patients also had considerable amounts of serum IgA and elevated levels of IgA with rheumatoid factor (RF) activity. IgA-CIC and IgA-RF were more frequent (P less than 0.03 and less than 0.001) in the 27 primary SS patients with, than in the 25 without extraglandular manifestations. IgA-CIC could play a role in mediating the tissue injury associated with primary SS.
Bendaoud
B
B
Laboratory of Immunology, Brest University Medical School Hospital, France.
Pennec
Y L
YL
Lelong
A
A
Le Noac'h
J F
JF
Magadur
G
G
Jouquan
J
J
Youinou
P
P
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood; D012859:Sjogren's Syndrome / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor