Infrared spectroscopy of heparins suggests that the region 750-950 cm-1 is sensitive to changes in iduronate residue ring conformation.
By careful definition of polymer environment, heparin i.r. spectra were examined in a region (750-950 cm-1) in which sulphate half-ester absorptions occur. Changes seen in this region when metal ion-heparin complexes are converted into heparinic acid, when heparin is carboxy-group-reduced and when various concentrations of Li(+)-heparin are examined are tentatively interpreted in terms of changes in the ring conformation of iduronate residues.
Grant
D
D
Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, Scotland, U.K.
Long
W F
WF
Moffat
C F
CF
Williamson
F B
FB
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006493:Heparin / Q000737:chemistry*; D006497:Heparan Sulfate / Q000737:chemistry; D006860:Hydrogen Bonding; D007067:Iduronic Acid / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013431:Sulfates / Q000737:chemistry
D006493:Heparin; D006497:Heparan Sulfate; D007067:Iduronic Acid; D008094:Lithium; D013431:Sulfates