Human thymosin-beta 4/6-26 gene is part of a multigene family composed of seven members located on seven different chromosomes.
We have isolated a cDNA encoding the human interferon-inducible gene 6-26, by screening a cDNA library with an oligodeoxynucleotide probe. Its sequence was found to be identical to that of the human thymosin-beta 4 cDNA, which encodes a protein present in most cell types, but whose function is not clear at present. By hybridization of the thymosin-beta 4/6-26 cDNA to the DNA of a panel of human-rodent somatic cell hybrids, we found that at least seven genes homologous to this cDNA are present in the human genome. We localized these genes, some of which might be pseudogenes, to seven distinct chromosomes, namely, chromosomes 1, 2, 4, 9, 11, 20, and X.
Clauss
I M
IM
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.
Wathelet
M G
MG
Szpirer
J
J
Islam
M Q
MQ
Levan
G
G
Szpirer
C
C
Huez
G A
GA
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid; D013947:Thymosin / Q000031:analogs & derivatives* / Q000235:genetics; D014960:X Chromosome; D000099201:Thymosin beta(4)
D013947:Thymosin; D000099201:Thymosin beta(4)