title: A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient.
abstract: The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.
authors.affiliation: Johns Hopkins Medical Institutions Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.
authors.forename: R
authors.initials: R
authors.lastname: Hoehn-Saric
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: G D
authors.initials: GD
authors.lastname: Pearlson
authors.forename: C S
authors.initials: CS
authors.lastname: Cox
authors.forename: S R
authors.initials: SR
authors.lastname: Machlin
authors.forename: E E
authors.initials: EE
authors.lastname: Camargo
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects*; D005625:Frontal Lobe / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005473:Fluoxetine