CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.
Cirrhosis of the rat liver was induced by a 12 week individualized CCl4/phenobarbital treatment. After treatment, all surviving animals (81%) showed cirrhosis of the liver. The cirrhosis induced was irreversible when evaluated 24 weeks after cessation of treatment. Quantitative liver function measurements were reduced in a differentiated manner. Ranked according to the most pronounced changes they are: capacity of urea-N synthesis (CUNS), galactose elimination capacity (GEC) and antipyrine clearance (APC). Hepatic glutathione concentrations were only slightly decreased after the CCl4 treatment. It is possible to produce a high incidence of irreversible cirrhosis with differentiated functional impairment in the rat.
Fischer-Nielsen
A
A
Department of Medicine A, Rigshospitalet, Copenhagen, Denmark.
Poulsen
H E
HE
Hansen
B A
BA
Hage
E
E
Keiding
S
S
D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000009:adverse effects*; D005690:Galactose / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000378:metabolism
D014508:Urea; D002251:Carbon Tetrachloride; D000983:Antipyrine; D005690:Galactose; D010634:Phenobarbital