title: Multicenter study of a single 500-mg dose of cefotaxime for treatment of uncomplicated gonorrhea.
abstract: One hundred thirty-seven evaluable patients with uncomplicated gonorrhea were treated with a single 500-mg intramuscular dose of cefotaxime. All isolates were susceptible to concentrations of cefotaxime less than or equal to 0.1 microgram/ml. The minimum concentration of cefotaxime needed to inhibit 90% of isolates was less than 0.04 microgram/ml. At follow-up, infection was eradicated in 181 of 187 (97%) infection sites. Bacteriologic cures of 100 of 101 (99%), 55 of 56 (98%), 23 of 25 (92%), and 3 of 5 (60%) were attained at the urethral, endocervical, rectal, and oropharyngeal sites, respectively. Side effects were minor, and 90% of patients rated the injection-site pain as absent or mild. A single 500-mg dose of cefotaxime is an effective, economic treatment for uncomplicated gonorrhea.
authors.affiliation: Division of Infectious Diseases, University of Colorado Health Science Center, Denver.
authors.forename: F N
authors.initials: FN
authors.lastname: Judson
authors.forename: L J
authors.initials: LJ
authors.lastname: Eron
authors.forename: F B
authors.initials: FB
authors.lastname: Lutz
authors.forename: K H
authors.initials: KH
authors.lastname: Rand
authors.forename: P O
authors.initials: PO
authors.lastname: Tennican
authors.forename: W J
authors.initials: WJ
authors.lastname: Mogabgab
mesh_terms: D000328:Adult; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use*; D003365:Costs and Cost Analysis; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male
chemical_list: D002439:Cefotaxime