Effect of the antiandrogen, WIN 49,596, on the descent of the testis in the male rat.
Testicular descent in the male rat is believed to be an androgen dependent event with dihydrotestosterone the most likely active androgen. To provide further insight into the endocrinology of this important physiological event, we treated male rats with the antiandrogen, WIN 49596 (50 mg./kg./day), from day 1 to day 27 of age and evaluated its effect on the post-natal androgen-dependent events in this animal model. It was determined that while treatment with WIN inhibited the weights of the ventral prostate, seminal vesicles and penis when compared to those seen in castrate animals, the drug only caused a 19% (3/16) inhibition in the descent of the testes when compared to the control group (0/16; p = 0.112). These data together with those previously obtained in animals exposed to selective inhibitors of the 5-alpha reductase enzyme suggest that other factors possibly working in tandem with androgens play a predominant role in testicular descent in the rat.
Bluestein
D
D
Department of Surgery, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Lemmi
C A
CA
Miller
L
L
Geesaman
B
B
Rajfer
J
J
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D013196:Dihydrotestosterone / Q000494:pharmacology; D008297:Male; D009919:Orchiectomy; D011278:Pregnanes / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects / Q000254:growth & development*
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D011278:Pregnanes; D011720:Pyrazoles; D013196:Dihydrotestosterone; C060492:zanoterone