Homologues of insulinase, a new superfamily of metalloendopeptidases.
On the basis of a statistical analysis of an alignment of the amino acid sequences, a new superfamily of metalloendopeptidases is proposed, consisting of human insulinase, Escherichia coli protease III and mitochondrial processing endopeptidases from Saccharomyces and Neurospora. These enzymes do not contain the 'HEXXH' consensus sequence found in all previously recognized zinc metalloendopeptidases.
Rawlings
N D
ND
Department of Biochemistry, Strangeways Research Laboratory, Cambridge, U.K.
Barrett
A J
AJ
D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007339:Insulysin / Q000235:genetics*; D008666:Metalloendopeptidases / Q000235:genetics*; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D009491:Neurospora / Q000201:enzymology / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012984:Software
D008666:Metalloendopeptidases; D007339:Insulysin