title: Lack of protective effect of thromboxane synthetase inhibitor (CGS-13080) on single dose radiated canine intestine.
abstract: The effect of a thromboxane A2 synthetase inhibitor (CGS-13080) on canine intestine was studied using a single dose of radiation, and radioactive microspheres were used to determine resultant blood flow. Thromboxane A2 causes vasospasm and platelet aggregation and may play a dominant role in radiation injury. However, there was no effect on the intestinal blood flow diminution occurring after radiation in this laboratory model using this thromboxane A2 synthetase inhibitor.
authors.affiliation: Division of Gynecologic Oncology, Georgetown University Medical Center, Washington, D.C. 2007.
authors.forename: J F
authors.initials: JF
authors.lastname: Barter
authors.forename: D
authors.initials: D
authors.lastname: Marlow
authors.forename: R K
authors.initials: RK
authors.lastname: Kamath
authors.forename: J
authors.initials: J
authors.lastname: Harbert
authors.forename: J R
authors.initials: JR
authors.lastname: Torrisi
authors.forename: W A
authors.initials: WA
authors.lastname: Barnes
authors.forename: R K
authors.initials: RK
authors.lastname: Potkul
authors.forename: J T
authors.initials: JT
authors.lastname: Newsome
authors.forename: G
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000818:Animals; D002588:Cesium Radioisotopes / Q000009:adverse effects; D004285:Dogs; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D007422:Intestines / Q000098:blood supply / Q000187:drug effects / Q000528:radiation effects*; D011725:Pyridines / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D012039:Regional Blood Flow / Q000187:drug effects / Q000528:radiation effects; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
chemical_list: D002588:Cesium Radioisotopes; D007093:Imidazoles; D011725:Pyridines; D011837:Radiation-Protective Agents; C037787:pirmagrel; D013930:Thromboxane-A Synthase