title: Complications after intravesical instillation of bacillus Calmette-Guerin: rhabdomyolysis and metastatic infection.
abstract: Two cases of adverse reaction to bacillus Calmette-Guerin (BCG) bladder instillations are reported. In both cases transient fevers and systemic symptoms developed following the instillations. After an additional instillation 1 patient had high fevers, severe myalgias and profound weakness followed by rhabdomyolysis and anuric renal failure, which required 3 weeks of hemodialysis before recovery. Extensive evaluation revealed no cause other than the BCG instillations. In the other patient a firm subcutaneous nodule gradually developed on the chest wall, which contained nonviable acid fast bacilli.
authors.affiliation: Community Hospital of Los Gatos-Saratoga, California.
authors.forename: R W
authors.initials: RW
authors.lastname: Armstrong
mesh_terms: D000038:Abscess / Q000209:etiology*; D058186:Acute Kidney Injury / Q000209:etiology; D000283:Administration, Intravesical; D001002:Anuria / Q000209:etiology; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D002277:Carcinoma / Q000556:secondary / Q000628:therapy; D002278:Carcinoma in Situ / Q000628:therapy; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000628:therapy
chemical_list: D001500:BCG Vaccine