HLA-D antigens and Paget's disease of bone.
HLA-A, -B, -C, -DR, and -DQ antigens were determined in 25 Ashkenazi Jews with Paget's disease of bone. HLA-DR2 was more frequent in the Pagetic patients compared with 57 healthy controls of the same ethnic origin. This finding concurs with a previous report and raises the possibility that HLA-DR2 may be associated with Paget's disease of bone, probably by predisposing the bone cells to viral infection.
Foldes
J
J
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Shamir
S
S
Brautbar
C
C
Schermann
L
L
Menczel
J
J
D005260:Female; D006681:HLA-D Antigens / Q000302:isolation & purification*; D015802:HLA-DR2 Antigen / Q000302:isolation & purification; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000208:ethnology / Q000276:immunology*
D006681:HLA-D Antigens; D015802:HLA-DR2 Antigen