Early bone changes in experimental osteoarthritis using microscopic computed tomography.
Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in cartilage. To evaluate the influence of the myectomy on the animals, a gait study was performed. This data reveals an alteration in acceleration at the foot-flat phase of gait in the operated limb only, providing early quantification of the interaction between mechanics and biology.
Dedrick
D K
DK
Department of Surgery, University of Michigan, Ann Arbor.
Goulet
R
R
Huston
L
L
Goldstein
S A
SA
Bole
G G
GG
D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology; D002356:Cartilage / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D005684:Gait / Q000502:physiology; D006168:Guinea Pigs; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed