Non-secretory adenomas of the pituitary treated by trans-ethmoidal sellotomy.
A consecutive series of 35 clinically non-secretory pituitary adenomas treated surgically by the transethmodial approach is presented. Mean age at presentation was 60 years, with a male-to-female ratio of 2:1. These tumours present later than hormone secreting tumours: 90% were over 2 cm in diameter at operation. Seventy-one per cent of patients had impaired vision and 89% had hypopituitarism. Surgical treatment relieved or significantly improved visual fields in 79% of patients with impaired vision. Ninety-one per cent required permanent hormone replacement. Mean follow-up was for 4.4 years. Five tumours recurred, causing recurrent visual symptoms. No tumours recurred in those patients treated with postoperative radiotherapy, but follow-up in this group was only for a mean of 2.7 years.
Shone
G R
GR
Department of Otolaryngology, University Hospital of Wales, Heath Park, Cardiff.
Richards
S H
SH
Hourihan
M D
MD
Hall
R
R
Thomas
J P
JP
Scanlon
M F
MF
D000236:Adenoma / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D007018:Hypopituitarism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D014786:Vision Disorders / Q000209:etiology