Dietary influences on the acute effects of anorectic drugs.
The effects of acute administration of d-amphetamine sulfate (0.0, 0.5, 1.0 and 2.0 mg/kg) and dl-fenfluramine hydrochloride (0.0, 1.5, 3.0 and 6.0 mg/kg) on food intake were examined in male Sprague-Dawley rats fed either a high-carbohydrate diet (carbohydrate equaled 65% of total calories) or a high-fat diet (fat equaled 65% of total calories). Animals were given ad lib access to the diets throughout the experiment. Drug injections were given at 0900 on experimental days and food intakes were measured at 1, 3 and 6 h postinjection. Amphetamine led to dose-related decreases in food intake for animals on both diets. The effects of amphetamine were most noticeable at 1 and 3 h postinjection. No differences in amphetamine's effects on food intake were found as a function of diet. Fenfluramine injections also led to dose-related reductions in food intake for animals in both dietary conditions. In contrast to amphetamine, however, fenfluramine led to greater reductions in food intake for rats fed the high-fat diet than for rats fed the high-carbohydrate diet. These data demonstrate that dietary variables must be considered when evaluating the anorectic actions of psychopharmacological agents.
Kanarek
R B
RB
Department of Psychology, Tufts University, Medford, MA 02155.
Glick
A L
AL
Marks-Kaufman
R
R
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology; D005518:Food Preferences / Q000187:drug effects*; D006815:Hunger / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001067:Appetite Depressants; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005277:Fenfluramine; D003913:Dextroamphetamine