Exogenous progesterone or indomethacin delays parturition in the viviparous lizard Sceloporus jarrovi.
Female Sceloporous jarrovi in late pregnancy given an ip injection of progesterone (50 ng/g body wt) or indomethacin (4 micrograms/g body wt) exhibited no change in the length of pregnancy when compared to saline-treated controls. In contrast, pregnant females given subcutaneous implants (constant release pellets) containing progesterone or indomethacin exhibited significantly delayed parturition when compared with females given control implants. Indomethacin treatment also disrupted the normal birth process when it occurred, as all females receiving this compound exhibited parturition of only a portion (24-32%) of the total clutch. A similar phenomenon occurred in one experiment following implantation of progesterone pellets. Histological examination of the corpora lutea and oviduct indicated no obvious difference in structure among any of the treatment groups.
Guillette
L J
LJ
Department of Zoology, University of Florida, Gainesville 32611.
DeMarco
V
V
Palmer
B D
BD
D000818:Animals; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007743:Labor, Obstetric / Q000187:drug effects / Q000502:physiology*; D008116:Lizards / Q000502:physiology*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*
D011374:Progesterone; D007213:Indomethacin