title: Acid-base status affects gas exchange in canine oleic acid pulmonary edema.
abstract: The effects of acidosis and alkalosis on pulmonary gas exchange were studied in 32 pentobarbital sodium-anesthetized intact dogs after induction of oleic acid (0.06 ml/kg) pulmonary edema. Gas exchange was assessed at constant ventilation and constant cardiac output, by venous admixture calculations and by intrapulmonary shunt measurements using the sulfur hexafluoride (SF6) method. Metabolic acidosis (pH 7.20) and alkalosis (pH 7.60) were induced with HCl and Carbicarb (isosmolar Na2CO3 and NaHCO3), respectively. Hypercapnia was induced by adding inspiratory CO2, whereas pH was allowed to change (respiratory acidosis, pH 7.20) or maintained constant (isolated hypercapnia). Mean intrapulmonary shunt and pulmonary arterial minus wedge pressure difference, respectively, changed from 44 to 33% (P less than 0.05) and from 9 to 10 mmHg (P greater than 0.05) in metabolic acidosis, from 44 to 62% (P less than 0.001) and from 12 to 8 mmHg (P less than 0.01) in metabolic alkalosis, from 40 to 42% (P greater than 0.05) and from 13 to 16 mmHg (P less than 0.05) in respiratory acidosis, from 42 to 52% (P less than 0.05) and from 8 to 12 mmHg (P less than 0.01) in isolated hypercapnia. These results indicate that acidosis, alkalosis, and hypercapnia markedly influence pulmonary gas exchange and/or pulmonary hemodynamics in dogs with oleic acid pulmonary edema.
authors.affiliation: Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Brimioulle
authors.forename: J L
authors.initials: JL
authors.lastname: Vachiery
authors.forename: P
authors.initials: P
authors.lastname: Lejeune
authors.forename: M
authors.initials: M
authors.lastname: Leeman
authors.forename: C
authors.initials: C
authors.lastname: Melot
authors.forename: R
authors.initials: R
authors.lastname: Naeije
mesh_terms: D000138:Acidosis / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D000471:Alkalosis / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D001639:Bicarbonates; D002254:Carbonates; D002302:Cardiac Output; D004285:Dogs; D004338:Drug Combinations; D006439:Hemodynamics; D006851:Hydrochloric Acid; D006935:Hypercapnia / Q000150:complications / Q000503:physiopathology; D008168:Lung / Q000098:blood supply; D019301:Oleic Acid; D009829:Oleic Acids; D011654:Pulmonary Edema / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange; D011669:Pulmonary Wedge Pressure; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D002254:Carbonates; D004338:Drug Combinations; D009829:Oleic Acids; C046283:sodium bicarbonate, sodium carbonate drug combination; D019301:Oleic Acid; D017693:Sodium Bicarbonate; D006851:Hydrochloric Acid