Small intestinal lesion resembling graft-vs-host disease. A case report in immunodeficiency and review of the literature.
We report graft-vs-host disease-like histology in a small intestinal biopsy specimen that was obtained from a patient with common variable immunodeficiency and related T-cell defect. We include findings from immunohistochemical studies and follow-up information. Review of the literature yielded only a small number of histologically documented cases of this lesion without previous bone marrow transplantation. Awareness of this clinicopathologic entity is important in the interpretation of gastrointestinal biopsy specimens.
Lee
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Division of Surgical Pathology, Washington University School of Medicine, St Louis, Mo.
Clouse
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Aliperti
G
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DeSchryver-Kecskemeti
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K
D001706:Biopsy; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007410:Intestinal Diseases / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D007583:Jejunum / Q000473:pathology; D008875:Middle Aged