title: Truncal vagotomy and pyloroplasty combined with valvular replacement in patients with ulcer disease.
abstract: In 1988, 5 patients (3 men and 2 women) with ulcer disease (mean age 56 +/- 8 years) underwent valvular replacement for aortic (No. = 4) or mitral disease (No. = 1). All patients had had gastroduodenal ulcers. Preoperative gastroscopy demonstrated active ulcers (No. = 4) and a healed pyloric ulcer with pyloric stenosis (No. = 1). Despite the presence of ulcers, a non-biologic prosthesis was preferred in each patient because of their young age (No. = 3), chronic atrial fibrillation requiring anticoagulant therapy (No. = 1), and refusal of the eventuality of subsequent reoperation (No. = 1). In each patient, a truncal vagotomy with pyloroplasty was performed simultaneously with the valvular procedures by the same incision. The postoperative courses were uneventful. With a mean follow-up of 15 +/- 3 months, no gastrointestinal bleeding was observed during anticoagulant therapy. With anticoagulant drugs, bleeding may occur with a frequency of 4% per patient treatment-year, half of which are gastrointestinal in origin. Nevertheless, in selected patients with gastroduodenal ulcers, performing a vagotomy-pyloroplasty simultaneously with valvular replacement allows implantation of a non-biologic prosthesis, with greater durability than bioprosthesis.
authors.affiliation: Department of Cardiovascular Surgery, University of Liege, Belgium.
authors.forename: J O
authors.initials: JO
authors.lastname: Defraigne
authors.forename: C
authors.initials: C
authors.lastname: Innocenti
authors.forename: G
authors.initials: G
authors.lastname: Dekoster
authors.forename: R
authors.initials: R
authors.lastname: Limet
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D010437:Peptic Ulcer / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D011708:Pylorus / Q000601:surgery*; D013997:Time Factors; D015167:Vagotomy, Truncal
chemical_list: D000925:Anticoagulants