title: 1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
authors.affiliation: Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
authors.forename: J
authors.initials: J
authors.lastname: Weinstock
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: J
authors.initials: J
authors.lastname: Samanen
authors.forename: J
authors.initials: J
authors.lastname: Hempel
authors.forename: J A
authors.initials: JA
authors.lastname: Finkelstein
authors.forename: R G
authors.initials: RG
authors.lastname: Franz
authors.forename: D E
authors.initials: DE
authors.lastname: Gaitanopoulos
authors.forename: G R
authors.initials: GR
authors.lastname: Girard
authors.forename: J G
authors.initials: JG
authors.lastname: Gleason
authors.forename: D T
authors.initials: DT
authors.lastname: Hill
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008968:Molecular Conformation; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D000179:Acrylates; D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D007202:Indicators and Reagents; D011945:Receptors, Angiotensin; D013876:Thiophenes; D000804:Angiotensin II; C068373:eprosartan