title: Clinical implications of food contaminated by aflatoxins.
abstract: Aflatoxins have been incriminated, mainly on circumstantial evidence, in hepatocellular carcinoma, acute hepatic failure and Reye's syndrome, but other possible effects of continuous or intermittent dietary exposure to aflatoxins, which occurs widely in the tropics, have received little study. Over the past 10 years evidence has steadily accumulated that incriminates aflatoxins in the aetiology of kwashiorkor, a widespread and serious disorder of children in the tropics, previously believed to be caused by protein deficiency. Investigation of human breast milk, undertaken initially to elucidate the pathogenesis of kwashiorkor in breastfed infants, has revealed widespread and serious exposure to aflatoxins from this source. Extension of these studies to pregnant women, in turn, revealed widespread and serious prenatal aflatoxin exposure. In laboratory and farm animals, such exposure has serious implications for immune and hepatic functions, and is detrimental to growth and development. Recent analysis of heroin samples show that heroin addicts may also be exposed to these toxins. These findings show that human exposure to aflatoxins may begin prenatally, persist during breastfeeding, and continue into adult life. It is postulated that aflatoxins (i) play a role in the aetiology of kwashiorkor, (ii) increase neonatal susceptibility to infection and jaundice, (iii) increase childhood susceptibility to infections and malignant disease, (iv) compromise immune responses to prophylactic immunisations and (v) may play a role in the pathogenesis of diseases in heroin addicts. There are indications also that acute, fatal aflatoxin poisoning which masquerades as 'hepatitis' may occur more frequently than is currently appreciated.
authors.affiliation: Department of Tropical Paediatrics & International Child Health, School of Tropical Medicine, Liverpool, U.K.
authors.forename: R G
authors.initials: RG
authors.lastname: Hendrickse
mesh_terms: D000208:Acute Disease; D000818:Animals; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000150:complications; D006556:Heroin Dependence; D006801:Humans; D007732:Kwashiorkor / Q000209:etiology; D008895:Milk, Human; D012202:Reye Syndrome / Q000209:etiology; D000096702:Aflatoxin Poisoning