Production of basic fibroblast growth factor in cultured rat brain microglia.
The production of basic fibroblast growth factor (bFGF) in cultured rat brain microglia was investigated. Rat brain microglia were found to express mRNA of bFGF in analysis by polymerase chain reaction (PCR) technique. Basic FGF was also detected in microglial cell lysate by Western blot analysis. These results indicate that microglia produce bFGF and possibly contribute to the regulation of neuronal development and regeneration.
Shimojo
M
M
Department of Neurochemistry, National Institute of Neuroscience, Tokyo, Japan.
Nakajima
K
K
Takei
N
N
Hamanoue
M
M
Kohsaka
S
S
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D002469:Cell Separation; D002478:Cells, Cultured; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis*; D015151:Immunoblotting; D051381:Rats
D016222:Fibroblast Growth Factor 2