title: The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24.
abstract: An EagI-EcoRI clone of human genomic DNA, p2-7, mapped to Xq24 has been sequenced. This analysis has confirmed the presence of a CpG island and has identified the first exon of the human LAMP2 gene, encoding a glycoprotein of the lysosomal membrane. Since the p2-7 clone corresponds to single-copy DNA, we can assign the human LAMP2 gene to Xq24.
authors.affiliation: Istituto di Tecnologie Biomediche Avanzate, CNR, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Manoni
authors.forename: C
authors.initials: C
authors.lastname: Tribioli
authors.forename: B
authors.initials: B
authors.lastname: Lazzari
authors.forename: G
authors.initials: G
authors.lastname: DeBellis
authors.forename: C
authors.initials: C
authors.lastname: Patrosso
authors.forename: R
authors.initials: R
authors.lastname: Pergolizzi
authors.forename: M
authors.initials: M
authors.lastname: Pellegrini
authors.forename: E
authors.initials: E
authors.lastname: Maestrini
authors.forename: S
authors.initials: S
authors.lastname: Rivella
authors.forename: P
authors.initials: P
authors.lastname: Vezzoni
mesh_terms: D000595:Amino Acid Sequence; D015703:Antigens, CD; D001483:Base Sequence; D003001:Cloning, Molecular; D015342:DNA Probes; D015226:Dinucleoside Phosphates / Q000235:genetics*; D005091:Exons; D006801:Humans; D052119:Lysosomal-Associated Membrane Protein 2; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins / Q000235:genetics*; D008745:Methylation; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D014960:X Chromosome
chemical_list: D015703:Antigens, CD; D015342:DNA Probes; D015226:Dinucleoside Phosphates; D052119:Lysosomal-Associated Membrane Protein 2; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins; C497811:LAMP2 protein, human; C015772:CpG dinucleotide