title: Percutaneous absorption of nicotinic acid derivatives in vitro.
abstract: The permeation rates through isolated epidermis of a homologous series of glycol, polyglycol, and alkyl esters of nicotinic acid were measured in vitro in a two-compartment diffusion cell assembly, using an isotonic buffered solution as the receiving phase. The esters were applied from aqueous solutions and also as the pure liquids. The results were consistent with those reported by other using compounds of equal or different structures either in vitro or in vivo. The experiments are compared in terms of partition equilibrium between vehicle and tissue and distribution from tissue to the receiving phase. It was demonstrated that the plateau observed in skin permeabilities of the compounds beyond a certain degree of lipophilicity is the result of the effect of water when used as the vehicle in the laboratory models.
authors.affiliation: Istituto di Chimica e Biochimica G. Ronzoni, Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Dal Pozzo
authors.forename: G
authors.initials: G
authors.lastname: Donzelli
authors.forename: E
authors.initials: E
authors.lastname: Liggeri
authors.forename: L
authors.initials: L
authors.lastname: Rodriguez
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D008433:Mathematics; D008954:Models, Biological; D009226:Myristates; D009539:Nicotinic Acids / Q000493:pharmacokinetics*; D010539:Permeability; D012869:Skin Absorption / Q000502:physiology*; D014867:Water
chemical_list: D009226:Myristates; D009539:Nicotinic Acids; D014867:Water; C008205:isopropyl myristate