title: Neurological complications following the use of continuous extradural analgesia with bupivacaine.
abstract: We describe a patient in whom continuous extradural analgesia with bupivacaine resulted in toxic plasma concentrations causing severe cerebral irritation. We discuss recent studies using continuous extradural bupivacaine, reports of toxicity and comment on the importance of monitoring drug concentrations.
authors.affiliation: Department of Anaesthesia, Charing Cross and Westminster Medical School, London.
authors.forename: N M
authors.initials: NM
authors.lastname: Dunne
authors.forename: W J
authors.initials: WJ
authors.lastname: Kox
mesh_terms: D000767:Anesthesia, Epidural / Q000009:adverse effects* / Q000379:methods; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D004660:Encephalitis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002045:Bupivacaine