title: Peripheral T-cell lymphomas: an evaluation of reproducibility of the updated Kiel classification.
abstract: Haematoxylin and eosin, and Giemsa stained sections from 100 peripheral T-cell lymphomas were examined blind on two occasions by four experienced haematopathologists in order to evaluate the inter- and intra-observer reproducibility of the updated Kiel classification for these malignancies. In all cases, the T-cell phenotype had been established previously in frozen section using a panel of monoclonal antibodies. Analysis by kappa statistics showed poor reproducibility, both overall and for most subtypes, with the exception of large cell anaplastic lymphoma. The distinction between low- and high-grade lymphomas was also unsatisfactory. These results indicate the need for improved precision in the definition of histological categories of peripheral T-cell lymphoma. The reproducibility of the update Kiel classification for peripheral T-cell lymphomas in its present form is inadequate.
authors.affiliation: Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Hastrup
authors.forename: S
authors.initials: S
authors.lastname: Hamilton-Dutoit
authors.forename: E
authors.initials: E
authors.lastname: Ralfkiaer
authors.forename: G
authors.initials: G
authors.lastname: Pallesen
mesh_terms: D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000145:classification; D016411:Lymphoma, T-Cell, Peripheral / Q000145:classification* / Q000473:pathology*; D015588:Observer Variation; D015203:Reproducibility of Results; D013223:Statistics as Topic