Multiple clonal chromosome abnormalities in Peyronie's disease.
Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.
Guerneri
S
S
Laboratorio di Citogenetica, Istituti Clinici di Perfezionamento, Milano, Italia.
Stioui
S
S
Mantovani
F
F
Austoni
E
E
Simoni
G
G
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000235:genetics*; D014998:Y Chromosome