Treatment of alopecia areata with diphenylcyclopropenone.
One hundred thirty-nine patients with severe alopecia areata (the majority with the subtotal, total, or universalis type) were treated with topical immunotherapy (diphenylcyclopropenone). Patients were initially treated unilaterally; the other side of the scalp served as a control. In 50.4% of the patients the response was either excellent (total regrowth) or satisfactory (subtotal regrowth with only a few remaining bald patches). The most frequent side effects were eczematous reactions with blistering, spreading of the induced contact eczema, and sleep disturbances.
van der Steen
P H
PH
Department of Dermatology, University of Nijmegen, The Netherlands.
van Baar
H M
HM
Perret
C M
CM
Happle
R
R
D000287:Administration, Topical; D000506:Alopecia Areata / Q000628:therapy*; D003521:Cyclopropanes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000209:etiology; D004485:Eczema / Q000139:chemically induced; D006801:Humans; D007167:Immunotherapy; D012008:Recurrence
D003521:Cyclopropanes; C029402:diphenylcyclopropenone