[Erythromycin pharmacokinetics in children after rectal and oral administration].
Pharmacokinetics of erythromycin base was studied clinically in children not older than 14 years treated with new children dosage forms of the antibiotic i. e. 0.1 and 0.25 g enteric coated tablets and 0.06 and 0.125 g suppositories. It was noted that the new dosage forms were characterized by higher availability which was 2.5-3 times higher than that after using the erythromycin base tablets without the coating. Systematic increasing of erythromycin availability after the use of the rectal suppositories was observed with increasing of the children age. Absolute absorption in newborns, sucklings and children over 1 year amounted to 28, 36 and 54 per cent respectively.
Nazarov
A D
AD
Strachunskiĭ
L S
LS
Firsov
A A
AA
Petrachenkova
N A
NA
Sushkova
V I
VI
Sheliakina
R D
RD
Kagan
E Z
EZ
Nesterova
L Ia
LIa
Sinitsyna
N I
NI
D000284:Administration, Oral; D000285:Administration, Rectal; D000293:Adolescent; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D013488:Suppositories; D013608:Tablets, Enteric-Coated
D013488:Suppositories; D013608:Tablets, Enteric-Coated; D004917:Erythromycin