Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
Rotello
R J
RJ
Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Lieberman
R C
RC
Purchio
A F
AF
Gerschenson
L E
LE
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects; D004847:Epithelial Cells; D005260:Female; D066298:In Vitro Techniques; D009707:Nucleosomes / Q000648:ultrastructure; D011817:Rabbits; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014599:Uterus / Q000166:cytology*
D009707:Nucleosomes; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta