title: Time-varying pulmonary arterial compliance.
abstract: We tested the hypothesis that pulmonary arterial compliance (Ca) varies during the ventilatory cycle. Pressure and flow in the main pulmonary artery were measured in open-chest dogs under chloralose anesthesia (n = 12) with a positive-pressure volume-cycled ventilator. Input impedance was calculated from the pressure and flow waves of heart cycles obtained immediately after the start of inspiration (SI) and immediately after the start of expiration (SE). A lumped parameter model was used to calculate Ca from the input impedance spectrum of the main pulmonary artery. Three levels of positive end-expiratory pressure (PEEP) were used before and after meclofenamate (n = 6) or vagotomy (n = 6). Ca was significantly greater at SE than at SI at each level of PEEP. PEEP increased Ca at SE but not at SI. None of these changes was altered by meclofenamate or vagotomy, suggesting that these differences of Ca were due to passive mechanical effects rather than an active neurohumoral mechanisms. We conclude that Ca is time varying during the ventilatory cycle because it is altered by the dynamic increase of lung volume between SI and SE, but not with the quasi-static increase of lung volume induced by raising the level of PEEP. These changes of Ca were unaffected by vagal feedback or inhibition of cyclooxygenase. We suggest that the increased Ca just after the start of expiration may result from dynamic shifts of blood volume from the extra-alveolar to the alveolar vessels.
authors.affiliation: Department of Medicine, State University of New York, Buffalo 14215.
authors.forename: B J
authors.initials: BJ
authors.lastname: Grant
authors.forename: J M
authors.initials: JM
authors.lastname: Fitzpatrick
authors.forename: B B
authors.initials: BB
authors.lastname: Lieber
mesh_terms: D000818:Animals; D004285:Dogs; D006439:Hemodynamics; D008176:Lung Volume Measurements; D008469:Meclofenamic Acid / Q000494:pharmacology; D011175:Positive-Pressure Respiration; D011651:Pulmonary Artery / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D008469:Meclofenamic Acid