title: Analysis of iodine-125 interstitial therapy in the treatment of localized carcinoma of the prostate.
abstract: Definitive treatment of localized carcinoma of the prostate has included radical surgery, external beam radiation therapy, and interstitial radiation therapy. The interstitial agent most commonly used is Iodine-125. Forty-eight patients were treated with interstitial radiation therapy using Iodine-125 implants with a median follow-up of 55 months. Forty-three percent of the evaluable patients had progressive disease with approximately 50% progressing at 5 years by Kaplan-Meier analysis. Overall actuarial survival in the group was 80% at 5 years. This and several other studies suggest that control of prostate cancer with Iodine-125 seeds may be suboptimal as compared with other treatment modalities, especially the radical retropubic prostatectomy. Analysis of treatment parameters is presented along with a discussion of the current status and future prospects for treatment of localized carcinoma of the prostate with interstitial radiation therapy.
authors.affiliation: Department of Surgery, University of Kentucky Medical Center, Lexington.
authors.forename: L G
authors.initials: LG
authors.lastname: Gomella
authors.forename: S M
authors.initials: SM
authors.lastname: Steinberg
authors.forename: M F
authors.initials: MF
authors.lastname: Ellison
authors.forename: W W
authors.initials: WW
authors.lastname: Reeves
authors.forename: R C
authors.initials: RC
authors.lastname: Flanigan
authors.forename: J W
authors.initials: JW
authors.lastname: McRoberts
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001706:Biopsy; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes