Effects on renal excretion in rats after injection of bile extracts from some fresh-water fish.
Bile acid extracts were prepared from grass carp, bighead, common carp, milk fish and tilapia. Injection of the fish bile extracts (3.6 mg/kg, i.v.) into rats increased renal excretion of water, sodium and potassium; decreased blood pressure; and hemolyzed RBCs. The diuretic, natriuretic, hypotensive and hemolytic actions of the bile extracts were stronger in grass carp, bighead and common carp, moderate in milk fish, and weakest in tilapia.
Chen
C F
CF
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Lin
M C
MC
Liu
F M
FM
Fang
H S
HS
D000818:Animals; D001647:Bile Acids and Salts / Q000008:administration & dosage / Q000633:toxicity*; D001794:Blood Pressure / Q000187:drug effects; D002347:Carps / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D005399:Fishes / Q000378:metabolism*; D006461:Hemolysis / Q000187:drug effects; D006586:Hexanes; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D012995:Solubility; D014020:Tissue Extracts / Q000008:administration & dosage / Q000633:toxicity
D001647:Bile Acids and Salts; D006586:Hexanes; D014020:Tissue Extracts; C026385:n-hexane; D000431:Ethanol; D012964:Sodium; D011188:Potassium