title: Efficacy of clorsulon for the treatment of experimentally induced infections of Fasciola hepatica in goats.
abstract: A dose titration study was undertaken to determine the efficacy of clorsulon against the adult stage of Fasciola hepatica in goats. Thirty-nine goats were experimentally infected with metacercariae of F hepatica. At 14 weeks after infection, each goat was assigned randomly to 1 of 5 groups. Goats in groups 1 to 4 received a single oral administration of clorsulon at dosages of 3.5, 7, 11, and 15 mg/kg of body weight, respectively. The fifth group of goats (control group) was infected with F hepatica, but were not treated with clorsulon. Postmortem examination of goats at 3 weeks after treatment revealed mean reductions in numbers of flukes of 83, 98, 99, and 100% for groups 1 to 4, respectively. Mean percentage of reduction in eggs following treatment of groups was 82, 98, 100, and 100%, respectively. The clinical effects of clorsulon in 24 goats that were not infected with F hepatica were studied. Goats in groups 1 to 3 received a single oral administration of clorsulon at dosages of 7, 21, and 35 mg/kg, respectively, every other day for a total of 3 doses/goat. Group-4 goats (control group) received a vehicle placebo. Goats in group 3 were subject to postmortem examination at 14 days after dosing. Abnormal signs or lesions that could be attributed to clorsulon were not found in any goat.
authors.affiliation: Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
authors.forename: S F
authors.initials: SF
authors.lastname: Sundlof
authors.forename: E L
authors.initials: EL
authors.lastname: Bliss
authors.forename: E C
authors.initials: EC
authors.lastname: Greiner
authors.forename: T Q
authors.initials: TQ
authors.lastname: Tran
authors.forename: M A
authors.initials: MA
authors.lastname: Wertenberger
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000209:etiology / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy* / Q000209:etiology / Q000469:parasitology; D006041:Goats; D008297:Male; D013424:Sulfanilamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000980:Antiplatyhelmintic Agents; D013424:Sulfanilamides; C015675:clorsulon