title: Initial process of diffusion of small molecules from blood vessels to the meninges in the young rat.
abstract: Pathways taken by peripherally administered small molecules when entering the brain were investigated in 6-day-old rats by radioautography and fluorescence microscopy after intravenous administration and rapid freezing. L-[U-14C]Phenylalanine, [U-14C]sucrose and sodium fluorescein reached the brain within less than 5 seconds. These blood-borne molecules were found in the subarachnoid cisterns and the superficial parenchyma. These results suggest a special permeability of the arachnoid layer and/or the pial vessels. Phenylalanine alone reached the deep parenchyma because of the existence of a specific endothelial carrier.
authors.affiliation: INSERM U 26, Hôpital Fernand Widal, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Lefauconnier
authors.forename: C
authors.initials: C
authors.lastname: Bouchaud
authors.forename: G
authors.initials: G
authors.lastname: Bernard
mesh_terms: D000818:Animals; D001345:Autoradiography; D001808:Blood Vessels / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D004058:Diffusion; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D008578:Meninges / Q000033:anatomy & histology / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000378:metabolism
chemical_list: D005452:Fluoresceins; D010649:Phenylalanine; D013395:Sucrose; D019793:Fluorescein