title: Effects of vasodilators on venous tone in vivo in dogs.
abstract: The authors investigated, in vivo, the effects of four vasodilators on venous tone in dogs. Baseline venous tone was determined from the pressure: diameter relationships in the inferior vena cava (VSIVC) and femoral vein (VSFV) as measured during several seconds of occlusion of the proximal inferior vena cava. All of the slopes were nearly linear. All vasodilators were administered in dosages sufficient to lower blood pressure by approximately 20%; these dosages also decreased systemic vascular resistance by 15% to 30%. Isosorbide dinitrate reduced VSIVC from 7.17 +/- 0.81 to 5.81 +/- 0.73 mmHg/mm and VSIVC from 59.4 +/- 13.5 to 37.2 +/- 6.6 mmHg/mm. Neither nifedipine nor nisoldipine altered VSIVC or VSFV. However, prazosin decreased VSIVC from 13.2 +/- 3.3 to 10.7 +/- 2.7 mmHg/mm and VSFV from 43.5 +/- 11.3 to 29.9 +/- 8.8 mmHg/mm. These results suggest that isosorbide dinitrate and prazosin decrease venous tone in vivo, whereas nifedipine and nisoldipine do not.
authors.affiliation: First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: G
authors.initials: G
authors.lastname: Narita
authors.forename: H
authors.initials: H
authors.lastname: Nomura
authors.forename: F
authors.initials: F
authors.lastname: Yasuma
authors.forename: K
authors.initials: K
authors.lastname: Miyaguchi
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: I
authors.initials: I
authors.lastname: Sotobata
mesh_terms: D000818:Animals; D001160:Arterioles / Q000187:drug effects; D004285:Dogs; D005268:Femoral Vein / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D015737:Nisoldipine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D012044:Regression Analysis; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014680:Veins / Q000187:drug effects* / Q000502:physiology; D014682:Vena Cava, Inferior / Q000187:drug effects
chemical_list: D014665:Vasodilator Agents; D015737:Nisoldipine; D009543:Nifedipine; D007548:Isosorbide Dinitrate; D011224:Prazosin