title: [The absorption of colostral immunoglobulins in newborn piglets. II. Effect of water or glucose solutions on the permeability of the newborn intestine].
abstract: The extent and the duration of the passage of intact proteins from the intestinal lumen into the bloodstream of newborn piglets was investigated. A total of 48 piglets from 4 litters were used in groups of 6 animals per experiment. The piglets were removed from the sow immediately after birth and placed in individual boxes of an automatic feeding device. Liquids were offered in trays, access to which was controlled by electronically operated gates. Volumes of 25 ml were allotted in hourly intervals. Porcine colostrum (6 x 25 ml) or bovine colostrum (24 x 25 ml) were either offered immediately, or after a 24 h fasting period without or with access to tap water. Two groups received 24 hourly rations of a 13 % glucose solution prior to the onset of feeding with porcine and bovine colostrum, respectively. The plasma levels of immunoglobulins were assessed by radial diffusion in blood samples drawn from a subcutaneous abdominal vein. The passage of intact proteins ceases between 12-18 hrs after the onset of feeding. Both the time course of the passage and the maximal levels achieved are unaffected after previous fasting or after tap water allowances only for 24 hrs. Previously fed glucose solution--in contrast--closes the gut barrier to subsequently ingested proteins. There was no difference in the postexperimental weight developments between groups.
authors.affiliation: Institut für Tierzucht und Tierverhalten (FAL) Mariensee.
authors.forename: F
authors.initials: F
authors.lastname: Klobasa
authors.forename: F
authors.initials: F
authors.lastname: Habe
authors.forename: E
authors.initials: E
authors.lastname: Werhahn
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003126:Colostrum / Q000276:immunology; D005947:Glucose / Q000378:metabolism; D007136:Immunoglobulins / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D010539:Permeability; D012996:Solutions; D013552:Swine / Q000378:metabolism*; D014867:Water / Q000378:metabolism
chemical_list: D007136:Immunoglobulins; D012996:Solutions; D014867:Water; D005947:Glucose