Antihypertensive action of a procyanidin glycoside from Rhamnus lycioides.
The antihypertensive action of a procyanidin glycoside isolated from Rhamnus lycioides aerial parts was studied in spontaneously and renal hypertensive rats. This compound, like 20 micrograms/kg i.v. of captopril, produced a very clear in vivo inhibition of angiotensin I converting enzyme when given at a dose of 3 mg/kg i.v.
Terencio
M C
MC
Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Universitat de València, Spain.
Sanz
M J
MJ
Paya
M
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D044946:Biflavonoids; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D002392:Catechin / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D044945:Proanthocyanidins; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D044946:Biflavonoids; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin; D002216:Captopril