title: Doppler ultrasonography of malignant melanomas of the uvea.
abstract: Doppler shifts were detected using duplex and color Doppler scanning in 41 of 42 patients with malignant melanomas of the uvea. Mean maximum tumor systolic velocity was 18.8 +/- 7.6 cm/s. Time-averaged maximum velocity in the tumor vessels was 12.3 +/- 5.3 cm/s. Maximum tumor velocity increased in four of eight tumors and was unchanged or had diminished in the other four 2 to 3 days after ruthenium plaque irradiation. Doppler shifts were undetectable in three tumors, markedly reduced in three tumors, and unchanged in one tumor 1 to 4 months after treatment. We detected minimal non-pulse-synchronized Doppler shifts in one of three tumors, and no shifts in the remaining two tumors 1 1/2 to 4 years after therapy. Color duplex scanning allowed a rapid overview of tumor vasculature and facilitated study of individual vessels.
authors.affiliation: Department of Ophthalmology, Hamburg University Hospital-Eppendorf, Federal Republic of Germany.
authors.forename: R F
authors.initials: RF
authors.lastname: Guthoff
authors.forename: R W
authors.initials: RW
authors.lastname: Berger
authors.forename: P
authors.initials: P
authors.lastname: Winkler
authors.forename: K
authors.initials: K
authors.lastname: Helmke
authors.forename: L C
authors.initials: LC
authors.lastname: Chumbley
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D001918:Brachytherapy; D006801:Humans; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000532:radiotherapy; D015203:Reproducibility of Results; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000532:radiotherapy