title: Functional structure of protein: exposed vs hidden function.
abstract: The dev analysis was used to construct the functional structure of protein (3). Based on this principle, the intramolecular interaction of dev peak was investigated. Two types of peak were observed: one is the hidden peak which interacts strongly with another region of the molecule and the other is the exposed peak whose interaction was weak. Analysis was made with trypsin and its inhibitor and on the intermolecular interaction between their exposed peaks. One interaction between their exposed peaks was found to coincide with one which had been already known to be authentic between their active sites.
authors.affiliation: Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Shiga-ken, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kiho
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Shimamoto
authors.forename: T
authors.initials: T
authors.lastname: Iwai
authors.forename: T
authors.initials: T
authors.lastname: Iwai
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D014357:Trypsin / Q000737:chemistry* / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000737:chemistry* / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D046911:Macromolecular Substances; D010446:Peptide Fragments; D014361:Trypsin Inhibitors; D014357:Trypsin