title: Transcriptional suppression of cellular gene expression by c-Myc.
abstract: High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.
authors.affiliation: Molecular Biology Research Program, Henry Ford Hospital, Detroit, Michigan 48202.
authors.forename: B S
authors.initials: BS
authors.lastname: Yang
authors.forename: T J
authors.initials: TJ
authors.lastname: Geddes
authors.forename: R J
authors.initials: RJ
authors.lastname: Pogulis
authors.forename: B
authors.initials: B
authors.lastname: de Crombrugghe
authors.forename: S O
authors.initials: SO
authors.lastname: Freytag
mesh_terms: D000818:Animals; D002460:Cell Line; D003094:Collagen / Q000235:genetics*; D015870:Gene Expression; D016259:Genes, myc; D016350:Leucine Zippers; D051379:Mice; D011401:Promoter Regions, Genetic; D013489:Suppression, Genetic; D014158:Transcription, Genetic
chemical_list: D003094:Collagen