[Quantification of T-lymphocyte subpopulations. Immunological marker in human immunodeficiency virus infections].
The absolute number of CD4+ and CD8+ T cells was counted directly in the blood of 75 healthy controls and 223 individuals infected with human immunodeficiency virus (HIV). The HIV-seropositive individuals were also classified clinically according to the system recommended by the Centers for Disease Control. We observed a pattern of changes in the T cell subset counts of the patient group. This pattern could be defined by five T cell stages ranging from normal T cell subset values to values representing severe T cell immunodeficiency. A close correlation was observed between the immunological and clinical classification of the patients. Quantification of T cell subsets may provide useful information in the follow-up of individuals infected with HIV, particularly in assessing the indications for antiviral therapy, and its effects.
Brinchmann
J E
JE
Institutt for transplantasjonsimmunologi, Rikshospitalet, Oslo.
Vartdal
F
F
Thorsby
E
E
Bucher
A
A
Frøland
S S
SS
Kittelsen
P
P
Kristoffersen
J
J
Baklien
K
K
D015658:HIV Infections / Q000145:classification / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology*