Lack of a relationship between colony-forming efficiency and surviving fraction at 2 Gy.
The relationship between in vitro radiation sensitivity and colony-forming efficiency has been examined for primary human tumors of the cervix, colorectum, and lymph gland. Tumors were cultured using the Courtenay-Mills soft agar clonogenic assay and radiosensitivity was assessed as surviving fraction at 2 Gy. There was no correlation between colony-forming efficiency and surviving fraction at 2 Gy, giving confidence to the use of surviving fraction at 2 Gy as a predictor of clinical outcome.
West
C M
CM
Cancer Research Campaign Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, United Kingdom.
Davidson
S E
SE
Pool
C
C
James
R D
RD
Schofield
P F
PF
D002470:Cell Survival / Q000528:radiation effects*; D002588:Cesium Radioisotopes; D003110:Colonic Neoplasms / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D014410:Tumor Stem Cell Assay; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy
D002588:Cesium Radioisotopes