The influence of ibuprofen on fracture repair: biomechanical, biochemical, histologic, and histomorphometric parameters in rats.
Ibuprofen is a widely used cyclo-oxygenase inhibitor in clinical practice. It has been demonstrated by others to have an inhibitory effect on fracture repair in animals. In the present study, we were unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague-Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12-week time interval. Fracture histology and serum osteocalcin levels were no different in treated animals than control animals. Furthermore, histomorphometric parameters of bone remodeling, including bone volume and bone formation rate in the intact tail vertebrae of these animals with unilateral femur fractures, were no different between treated and control animals.
Huo
M H
MH
Department of Orthopaedics & Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06510.
Troiano
N W
NW
Pelker
R R
RR
Gundberg
C M
CM
Friedlaender
G E
GE
D000818:Animals; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects; D002146:Bony Callus / Q000737:chemistry / Q000187:drug effects; D005260:Female; D005264:Femoral Fractures / Q000473:pathology / Q000503:physiopathology*; D007052:Ibuprofen / Q000494:pharmacology*; D015675:Osteocalcin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D013623:Tail; D014945:Wound Healing / Q000187:drug effects
D015675:Osteocalcin; D007052:Ibuprofen