title: Bone mass in totally thyroidectomized patients. Role of calcitonin deficiency and exogenous thyroid treatment.
abstract: Calcitonin has an uncertain role in the preservation of bone mass. Since surgical thyroidectomy abolishes the calcitonin secretion in response to calcium, the bone mineral density at the radius shaft and lumbar spine was measured in 60 patients (5 men, 16 premenopausal, 34 postmenopausal euparathyroid and 5 postmenopausal hypoparathyroid women) who had undergone near total thyroidectomy for thyroid cancer 8.4 +/- 0.7 years before the study. All patients were maintained on suppressive doses of thyroid hormones. Bone mineral density values of the radius shaft (expressed as Z-score) of 34 postmenopausal euparathyroid women was significantly below the normal average (mean +/- SEM = -0.59 +/- 0.2; p = 0.01). Bone mineral density of the lumbar spine was also below the normal average although the difference only approached statistical significance (-0.36 +/- 0.2; 0.05 less than p less than 0.1). The bone mineral density of neither the radius nor the spine differed from normal levels in the premenopausal women and the postmenopausal hypoparathyroid women. Unexpectedly, the bone mineral density of the spine was significantly increased in the 5 thyroidectomized men. The results indicate that thyroidectomized women have a diminished bone mass after the menopause only if parathyroid function is normal. Since the patients were receiving thyroid hormone at suppressive doses, the present study is not able to separate the relative contributions of calcitonin deficit and exogenous thyroid on bone mass loss.
authors.affiliation: Laboratorio de Osteopatias Médicas, Buenos Aires.
authors.forename: D C
authors.initials: DC
authors.lastname: Gonzalez
authors.forename: C A
authors.initials: CA
authors.lastname: Mautalen
authors.forename: P H
authors.initials: PH
authors.lastname: Correa
authors.forename: E
authors.initials: E
authors.lastname: el Tamer
authors.forename: S
authors.initials: S
authors.lastname: el Tamer
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000378:metabolism / Q000502:physiology; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood / Q000627:therapeutic use*; D013965:Thyroidectomy
chemical_list: D010710:Phosphates; D013963:Thyroid Hormones; D002116:Calcitonin; D002118:Calcium