title: Hemodynamic and catecholamine response to isoflurane versus droperidol in complement to fentanyl anaesthesia.
abstract: Droperidol (0.03 mg.kg-1 to 0.25 mg.kg-1) with fentanyl has been reported to be less efficient than volatile agents in the prevention of haemodynamic responses to surgery. The aim of this study was to investigate the use of high-dose droperidol in complement to fentanyl in comparison with isoflurane and fentanyl anaesthesia. Thirty patients undergoing laryngectomy were studied. Systolic blood pressure (SBP), heart rate (HR) and plasma catecholamines were analysed both during anaesthesia and during recovery. During surgery, SBP epinephrine (E) levels did not change in either group. HR was slightly lower during droperidol fentanyl anaesthesia. Norepinephrine (NE) levels were significantly higher in the droperidol group than in the isoflurane group (P less than 0.05). During recovery, in both groups, SBP increased by 20% whereas E levels increased by 65%. NE levels increased post-operatively in both groups, but this rise was significantly higher in the droperidol group (P less than 0.01). It is concluded that the two techniques contribute to the haemodynamic stability during surgery, but do not prevent haemodynamic instability during recovery.
authors.affiliation: Department of Anaesthesiology, Institut Gustave-Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Tandonnet
authors.forename: J L
authors.initials: JL
authors.lastname: Bourgain
authors.forename: K
authors.initials: K
authors.lastname: McGee
authors.forename: E
authors.initials: E
authors.lastname: Comoy
authors.forename: J
authors.initials: J
authors.lastname: Truffa-Bachi
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D002395:Catecholamines / Q000097:blood*; D004329:Droperidol / Q000494:pharmacology*; D005283:Fentanyl / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D007825:Laryngectomy; D011184:Postoperative Period; D011897:Random Allocation
chemical_list: D002395:Catecholamines; D007530:Isoflurane; D004329:Droperidol; D005283:Fentanyl