[Use of tryptophan and thyroidin for complex correction of hormonal disorders in experimental hypogalactia in rats].
The interlinked functioning of the hypothalamo-hypophyseo-breast and hypothalamo-hypophyseo-thyroid systems in experimental hypogalactia (electric stimulation) as well as a possibility of effective correction of neuroendocrine disorders of lactation were studied using tryptophan in combination with microdoses of thyroidin. The hypothalamic and blood concentrations of monoamines (MA) were determined by fluorometry (spectrofluorometers SFM-22, Contron, Switzerland), the blood levels of hormones were determined by a radioimmunoassay. The effect of chronic stress on the monoaminergic hypothalamic system was shown to be based on an increase in the catecholaminergic tone and suppression of serotoninergic tone. It resulted in the suppression of the synthesis and secretion of prolactin, STH, in an elevated blood level of TSH and a considerable reduction of the level of thyroid hormones. The result was weakened secretory function of the breast. Tryptophan and thyroidin administration to rats, subjected to stress, returned to normal function. The investigation brought to light the idea of pathogenesis of hypogalactia, resulting in a new approach to therapy of this pathological condition.
Aliev
M G
MG
Ismaĭlov
Iu B
IuB
Sadykh-zade
R A
RA
D000818:Animals; D015306:Biogenic Monoamines / Q000097:blood; D004359:Drug Therapy, Combination; D004558:Electric Stimulation; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D007775:Lactation Disorders / Q000188:drug therapy* / Q000378:metabolism; D011388:Prolactin / Q000096:biosynthesis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood; D014364:Tryptophan / Q000627:therapeutic use*
D015306:Biogenic Monoamines; D013963:Thyroid Hormones; C004227:thyroidin; D014364:Tryptophan; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone