title: Subcortical adaptive filtering in the auditory system: associative receptive field plasticity in the dorsal medial geniculate body.
abstract: Highly specific subcortical receptive field (RF) plasticity was found in the dorsal division of the guinea pig medial geniculate body during cardiac conditioning to a tonal frequency. There was increased response to the conditioned-stimulus (CS) frequency, and there were decreased responses to adjacent frequencies, especially at the pretraining best frequency (BF), which often resulted in a shift of tuning such that the CS became the new BF. Moreover, 1 hr later the effects were stronger, more sharply tuned, and centered on the CS frequency. A sensitization paradigm produced only broad, general increases of response across the RF. These findings reveal that the analysis of sensory RF dynamics is a valuable approach to understanding the neural mechanisms of information processing in learning and memory.
authors.affiliation: Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
authors.forename: J M
authors.initials: JM
authors.lastname: Edeline
authors.forename: N M
authors.initials: NM
authors.lastname: Weinberger
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000502:physiology*; D005829:Geniculate Bodies / Q000502:physiology*; D006168:Guinea Pigs; D008144:Loudness Perception / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010897:Pitch Discrimination / Q000502:physiology*