title: Lactic acidosis associated with high-dose niacin therapy.
abstract: We have reported a case of lactic acidosis induced by ingestion of sustained-release nicotinic acid. Prompt recovery followed treatment with glucose-containing fluids and discontinuation of nicotinic acid therapy.
authors.affiliation: Department of Internal Medicine, St. Joseph Hospital, Houston, Tex.
authors.forename: T P
authors.initials: TP
authors.lastname: Earthman
authors.forename: L
authors.initials: L
authors.lastname: Odom
authors.forename: C A
authors.initials: CA
authors.lastname: Mullins
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D007773:Lactates / Q000097:blood / Q000378:metabolism; D008297:Male; D009525:Niacin / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence
chemical_list: D003692:Delayed-Action Preparations; D007773:Lactates; D009525:Niacin