Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type beta 1, beta 2, and beta 1.2.
The transforming growth factors type beta 1, beta 2, and beta 1.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly over-express mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport.
Schluesener
H J
HJ
Department of Neurology, University of Wuerzburg, Federal Republic of Germany.
D001692:Biological Transport / Q000187:drug effects; D004336:Drug Antagonism; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020112:Rhodamine 123; D012235:Rhodamines; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D005456:Fluorescent Dyes; D012235:Rhodamines; D016212:Transforming Growth Factor beta; D020112:Rhodamine 123