title: Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.
abstract: The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.
authors.affiliation: Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: F
authors.initials: F
authors.lastname: Serour
authors.forename: M
authors.initials: M
authors.lastname: Dan
authors.forename: A
authors.initials: A
authors.lastname: Gorea
authors.forename: A
authors.initials: A
authors.lastname: Yellin
authors.forename: Y
authors.initials: Y
authors.lastname: Lieberman
authors.forename: S A
authors.initials: SA
authors.lastname: Berger
mesh_terms: D000284:Administration, Oral; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D015242:Ofloxacin