title: Transplantation of vascularized composite mandibular allografts in young cynomolgus monkeys.
abstract: In the search for donor tissue for massive craniofacial defects, the transplantation of somatic tissue allografts was explored. Four young, out-bred cynomolgus monkeys were the recipients of orthotopic hemimandibular allotransplants from nonrelated cynomolgus monkeys. The transplant consisted of one-half of the mandible with attached muscle, skin, and mucosa. Cyclosporine 15 mg/kg/day was given subcutaneously each day. The 4 monkeys were observed for 13, 27, 63, and 65 days, respectively. All transplants showed primary wound healing and hair growth. The 2 longest survivors chewed, ate a normal diet, and gained weight. Two allografts showed severe rejection signs at 2 to 3 weeks, and the monkeys were euthanized. One monkey had a second episode of rejection that could not be reversed, and it was killed. The fourth monkey died of undetermined causes.
authors.affiliation: Division of Plastic Surgery, University of California, Irvine.
authors.forename: M E
authors.initials: ME
authors.lastname: Gold
authors.forename: J
authors.initials: J
authors.lastname: Randzio
authors.forename: H
authors.initials: H
authors.lastname: Kniha
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: H H
authors.initials: HH
authors.lastname: Park
authors.forename: J P
authors.initials: JP
authors.lastname: Stein
authors.forename: K
authors.initials: K
authors.lastname: Booth
authors.forename: H E
authors.initials: HE
authors.lastname: Gruber
authors.forename: D W
authors.initials: DW
authors.lastname: Furnas
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use; D006084:Graft Rejection; D008252:Macaca fascicularis; D008334:Mandible / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation*; D009132:Muscles / Q000637:transplantation; D011859:Radiography; D016038:Skin Transplantation; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins