title: Use of prophylactic otic drops after tympanostomy tube insertion.
abstract: In a 1-year prospective study, 60 patients with chronic serous otitis media underwent bilateral tympanocentesis with tube insertion. The right ear was treated with dexapolyspectran (a solution consisting of polymyxin B sulfate, neomycin sulfate, sulfonamide, and hydrocortisone) intraoperatively and for 72 hours afterward, and the left ear served as the control. All patients were followed up at weekly intervals for the first month. Five (8.3%) out of 60 experimental ears had purulent otorrhea within the first 14 days after surgery, compared with eight (13.3%) out of 60 control ears. Statistical analysis showed no difference between the two groups.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, American University of Beirut, Lebanon.
authors.forename: H H
authors.initials: HH
authors.lastname: Ramadan
authors.forename: T
authors.initials: T
authors.lastname: Tarazi
authors.forename: G M
authors.initials: GM
authors.lastname: Zaytoun
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008876:Middle Ear Ventilation; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D010034:Otitis Media with Effusion / Q000601:surgery*; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D013449:Sulfonamides / Q000008:administration & dosage / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D004338:Drug Combinations; D013449:Sulfonamides; C068732:polymyxin B sulfate, neomycin sulfate, sulfonamide, and hydrocortisone drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone