title: Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients.
abstract: Three male patients are described in whom anorgasmia developed during treatment with fluoxetine for depression. During attempts to treat the anorgasmia with cyproheptadine, all three patients suffered a relapse of depressive symptoms. The possible mechanism of this effect is discussed in relation to serotonergic systems.
authors.affiliation: Nashua Brookside Hospital, N.H.
authors.forename: R
authors.initials: R
authors.lastname: Feder
mesh_terms: D000328:Adult; D003533:Cyproheptadine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004347:Drug Interactions; D005473:Fluoxetine / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009948:Orgasm / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012008:Recurrence; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D011985:Receptors, Serotonin; D005473:Fluoxetine; D003533:Cyproheptadine