Immunogenetics of HLA.
The enormous contributions of Professor Karl Landsteiner are summarized focusing on his discovery of the ABO, MN, and P blood group systems as well as his conceptualization of the hapten concept. The HLA system, the major histocompatibility complex in humans, is discussed from the point of view of its genetic organization, the polymorphism that is recognized by T lymphocytes and the presently defined molecular polymorphism. The structure-function relationship of T cell recognition of class II molecules, based on the known crystallographic structure of an HLA class I molecule, is presented.
Bach
F H
FH
Department of Laboratory Medicine and Pathology, Medical School, Minneapolis, Minnesota.
D001483:Base Sequence; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013329:Structure-Activity Relationship
D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II