Pharmacological treatment dose-relatedly improves learning and hippocampal long-term potentiation.
In the CA1 region of hippocampal slices prepared from guinea-pigs, which had been orally treated with sabeluzole, long-term potentiation was significantly enhanced in those slices obtained from animals given 2.5 or 10.0 mg/kg. In an active avoidance task oral treatment of guinea-pigs with 2.5 or 10.0 mg/kg of sabeluzole significantly increased learning. The dose of 0.63 mg/kg was inactive in both paradigms. These results provide new evidence supporting the involvement of LTP in learning.
Ashton
D
D
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Werbrouck
L
L
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004594:Electrophysiology; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007858:Learning / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D010880:Piperidines; D013844:Thiazoles; C055163:sabeluzole