Transcription of N-myc and proliferation-related genes is linked in human neuroblastoma.
A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.
Raschellà
G
G
Division of Physics and Biomedical Sciences, CRE ENEA Casaccia, Rome, Italy.
Negroni
A
A
Giubilei
C
C
Romeo
A
A
Ferrari
S
S
Castello
M A
MA
Dominici
C
C
D015152:Blotting, Northern; D015139:Blotting, Southern; D002455:Cell Division / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis; D015536:Down-Regulation; D005434:Flow Cytometry; D016259:Genes, myc; D016158:Genes, p53; D006657:Histones / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D006657:Histones; D012333:RNA, Messenger; D004247:DNA