title: Baseline sero-epidemiology of hepatitis B virus infection in children and teenagers in Italy. A survey before mass hepatitis B vaccination.
abstract: During the period May 1987 to November 1989, the prevalence of hepatitis B virus (HBV) markers was determined by ELISA in serum samples of 7405 (55% male, 45% female) apparently healthy persons 3-19 years of age in Italy. Earlier studies of adults there had shown an intermediate degree of HBV endemicity (hepatitis B surface antigen carrier rate greater than 2%). Persons were selected by systematic cluster sampling in five different geographical areas of Italy. The overall prevalence of hepatitis B surface antigen (HBsAg) was 0.6%. The overall prevalence of at least one marker of HBV was 2.8%; it increased from 1.7% among children 3-5 years of age to 4.5% in teenagers 17-19 years of age (P less than 0.001). The prevalence of any HBV marker was higher in southern then in northern areas (3.5% vs. 1.8%, P less than 0.001). A significant association was found with sociodemographic features. Persons whose fathers had less than 6 years of schooling had a 2.3-fold risk (C.I. 95% = 1.5-3.4) while those belonging to a household of six or more under one roof had a 1.7-fold risk (C.I. 95% = 1.2-2.4) of previous exposure to HBV infection. These findings indicate that, today in Italy, exposure to HBV infection at a young age is very low and suggest a shift towards a low degree of endemicity following improvements in socio-economic conditions, decreased family size and increasing use of disposable syringes during recent years.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratory of Epidemiology, I.S.S., Roma, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Stroffolini
authors.forename: M
authors.initials: M
authors.lastname: Chiaramonte
authors.forename: A
authors.initials: A
authors.lastname: Craxì
authors.forename: E
authors.initials: E
authors.lastname: Franco
authors.forename: M
authors.initials: M
authors.lastname: Rapicetta
authors.forename: R
authors.initials: R
authors.lastname: Trivello
authors.forename: D
authors.initials: D
authors.lastname: De Mattia
authors.forename: I
authors.initials: I
authors.lastname: Mura
authors.forename: A
authors.initials: A
authors.lastname: Giammanco
authors.forename: G
authors.initials: G
authors.lastname: Rigo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D015995:Prevalence; D012959:Socioeconomic Factors
chemical_list: D006514:Hepatitis B Surface Antigens