[Local anesthetic effect and subjective tolerance of a single dose of 0.25% bupranolol in probands with healthy eyes. Randomized parallel double-blind study].
.25% Bupranolol in an oily solution decreases corneal sensitivity statistically significant from the 3. to the 15. minute after the application. The maximum of decrease is found between the 6. and the 15. minute in contrast to beta-blockers in aqueous solution (1.-3. minute). The topical subjective compatibility of 0.25% Bupranolol equals that of preserved 0.5% Timolol.
Bastian
B
B
Augenklinik mit Poliklinik, Universität des Saarlandes, Homburg/Saar.
Höh
H
H
D000328:Adult; D000772:Anesthesia, Local; D002046:Bupranolol / Q000009:adverse effects; D003315:Cornea / Q000294:innervation*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009619:Nociceptors / Q000187:drug effects*; D009883:Ophthalmic Solutions; D010147:Pain Measurement
D009883:Ophthalmic Solutions; D002046:Bupranolol