title: Human T-lymphotropic virus type 1-associated myelopathy and primary sclerosing cholangitis.
abstract: We report the first case of human T-lymphotropic type 1-associated myelopathy (HAM) linked with primary sclerosing cholangitis (PSC). The patient, a 44-year-old woman, also suffered from ulcerative colitis and polyarthritis. Two years and nine months after the clinical onset of PSC, the coexistence of HAM was shown by neurological manifestations characterized by slowly progressive symmetrical myelopathy, predominantly involving pyramidal tracts, and positive antibodies to human T-lymphotropic virus type 1 in serum as well as in cerebrospinal fluid.
authors.affiliation: Department of Internal Medicine, Takaoka City Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takegoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: K
authors.initials: K
authors.lastname: Tsukada
authors.forename: K
authors.initials: K
authors.lastname: Okuda
mesh_terms: D000328:Adult; D001168:Arthritis / Q000150:complications; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications; D005260:Female; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000150:complications*