Hemangiopericytoma in a male breast. Report of a case with cytologic, histologic and immunochemical studies.
A hemangiopericytoma in a male breast was studied by fine needle aspiration (FNA) biopsy. The FNA smears contained tissue clumps showing knob-like formations of atypical cells, spindle-shaped cells and fragments of capillaries lined by normal endothelial cells. Immunocytochemical study showed a positive reaction for vimentin, but a negative reaction for desmin and keratin. Staining for Factor VIII was positive only in the capillaries and endothelial cells. The cytodiagnosis was "mesenchymal tumor." Histopathologic study of the mastectomy specimen made the final diagnosis of hemangiopericytoma. While FNA cytology and immunocytochemistry cannot make a definitive diagnosis of this rare vascular tumor, they can be decisive in planning the surgical treatment, as in the present case.
Jiménez-Ayala
M
M
Department of Pathology, Gregorio Maranon General Hospital, Madrid, Spain.
Díez-Nau
M D
MD
Larrad
A
A
Ferrer-Vergara
L
L
Rodriguez-Costa
J
J
Lacruz
C
C
Escalona-Zapata
J
J
D000328:Adult; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002843:Chromatin / Q000648:ultrastructure; D003581:Cytodiagnosis; D005167:Factor VII / Q000032:analysis; D006393:Hemangiopericytoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D008408:Mastectomy; D014746:Vimentin / Q000032:analysis
D002843:Chromatin; D014746:Vimentin; D005167:Factor VII