title: The peripherin gene maps to mouse chromosome 15.
abstract: We have mapped the mouse peripherin gene, Prph, to chromosome 15 by means of Southern analysis of a panel of Chinese hamster/mouse somatic cell hybrids using a rat peripherin cDNA probe. Peripherin is a recently characterized type III intermediate filament expressed in the peripheral and the central nervous system. Although its exact function is not known, peripherin is likely to be involved in the neuronal cytoskeleton, a role it shares with other intermediate filaments, such as the neurofilament proteins. The intermediate filament gene family is believed to have evolved via gene duplication and dispersal throughout the genome; these processes have resulted in clusters of intermediate filament genes on specific chromosomes and conservation of these chromosomal locations among mammalian species.
authors.affiliation: Department of Biology, Yale University, New Haven, Connecticut 06511.
authors.forename: J W
authors.initials: JW
authors.lastname: Pendleton
authors.forename: S M
authors.initials: SM
authors.lastname: Violette
authors.forename: L W
authors.initials: LW
authors.lastname: Hunihan
authors.forename: L A
authors.initials: LA
authors.lastname: Greene
authors.forename: F H
authors.initials: FH
authors.lastname: Ruddle
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D015342:DNA Probes; D006822:Hybrid Cells; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008562:Membrane Glycoproteins; D051379:Mice; D005810:Multigene Family; D009419:Nerve Tissue Proteins; D064531:Peripherins
chemical_list: D015342:DNA Probes; D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D064531:Peripherins; C579005:Prph protein, mouse; C579004:Prph protein, rat