title: [A case of beriberi heart--with special reference to the rapid effect of fursultiamine on hemodynamics].
abstract: A 33-year-old man was admitted to Kushiro City General Hospital on February 27, 1989, because of palpitation, shortness of breath and anasarca. Eight months previously he had noted the onset of pretibial edema, which had progressed to anasarca. He had had a meal only once a day for nine months. Physical examination revealed a blood pressure of 114/46 mmHg and pulse rate of 80/min. The 3rd sound was audible. No rales in the chest and no hepatosplenomegaly were noted. Ascites, pretibial edema and anasarca were present. Vibration sensation was diminished, and the deep tendon reflexes were absent in the legs. The blood thiamine level on the 4th day of hospitalization decreased to 2.9 micrograms/dl. The red cell transketolase activity and TPP effect on the 10th hospital day were 0.76 IU/gHb and 11%, respectively. A chest roentogenogram showed pulmonary congestion and cardiomegaly (CTR 61.3%). The electrocardiogram showed non-specific T wave changes. On the echocardiogram, remarkable pericardial effusion and diffuse hypertrophy of the left ventricular wall were observed. In addition, the left ventricular wall motion showed a hyperkinetic state. On the basis of these findings, the diagnosis of beriberi heart was made. The hemodynamic study performed on the 10th hospital day showed a remarkable high cardiac output (CO) of 10.7 l/min and an extremely reduced total peripheral resistance (TPR) of 352 dynes.sec.cm-5. 15 min after intravenous administration of Fursultiamine 100 mg, CO decreased to 7.24 l/min and TPR increased to 848 dynes.sec.cm-5. Following the administration of Fursultiamine 75 mg, po/day, his symptoms and abnormal findings of clinical examination data rapidly improved.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, Kushiro City General Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Oimatsu
authors.forename: T
authors.initials: T
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Sawai
authors.forename: R
authors.initials: R
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Mukai
authors.forename: C
authors.initials: C
authors.lastname: Kudoh
mesh_terms: D000328:Adult; D001602:Beriberi / Q000188:drug therapy* / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D005666:Fursultiamin / Q000008:administration & dosage / Q000627:therapeutic use*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D013831:Thiamine / Q000097:blood
chemical_list: D005666:Fursultiamin; D013831:Thiamine