title: Phase II study of 4'-deoxydoxorubicin (esorubicin) in advanced or metastatic adenocarcinoma of the stomach.
abstract: 4'-deoxydoxorubicin (DxDx) was administered to 17 patients with locally advanced or metastatic gastric adenocarcinoma. Treatment cycles were repeated every 21 days. 15 eligible patients with a Karnofsky performance status of 50% or better (median: 70%) received at least one course of treatment; a median of 2 courses of DxDx was delivered (range 1 to 13). The median dose per treatment course was 26 mg/m2 (range 8.5 mg/m2 to 53 mg/m2). 69% of patients required dose reduction following the first course of therapy due to grade 3 or 4 myelosuppression, primarily neutropenia. The principal side effects included anemia, mild gastrointestinal toxicities, and alopecia; one patient experienced a 10% decrease in cardiac ejection fraction without clinical cardiac toxicity. Of the 15 patients assessable for response and toxicities, 1 patient had a partial response lasting 2.5 months. The median survival from the time of the first treatment was 3.3 months. We conclude that DxDx has only limited activity in the treatment of advanced gastric adenocarcinoma.
authors.affiliation: Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, CA.
authors.forename: G
authors.initials: G
authors.lastname: Somlo
authors.forename: J
authors.initials: J
authors.lastname: Doroshow
authors.forename: S
authors.initials: S
authors.lastname: Akman
authors.forename: L
authors.initials: L
authors.lastname: Leong
authors.forename: K
authors.initials: K
authors.lastname: Margolin
authors.forename: M
authors.initials: M
authors.lastname: McNamara
authors.forename: P
authors.initials: P
authors.lastname: Multhauf
authors.forename: D
authors.initials: D
authors.lastname: Blayney
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Raschko
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000328:Adult; D000368:Aged; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D004317:Doxorubicin; C030851:esorubicin