title: Clinical application of PET for the evaluation of brain tumors.
abstract: The combination of FDG and PET has demonstrated clinical utility in the evaluation of patients with brain tumors. At the time of diagnosis, FDG PET provides information concerning the degree of malignancy and patient prognosis. After therapy, FDG PET is able to assess persistence of tumor, determine degree of malignancy, monitor progression, differentiate recurrence from necrosis, and assess prognosis. Other studies using PET provide information that may be clinically useful. Determination of tumor blood flow and permeability of the blood-brain barrier may help in the selection of appropriate therapy. Amino acid imaging using 11C-methionine is being evaluated in patients with brain tumors and provides different information than FDG imaging.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: R E
authors.initials: RE
authors.lastname: Coleman
authors.forename: J M
authors.initials: JM
authors.lastname: Hoffman
authors.forename: M W
authors.initials: MW
authors.lastname: Hanson
authors.forename: H D
authors.initials: HD
authors.lastname: Sostman
authors.forename: S C
authors.initials: SC
authors.lastname: Schold
mesh_terms: D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose