Behavioural effects of peripherally injected interleukin-1: role of prostaglandins.
To investigate the possible mediation by prostaglandins of changes in behaviour induced by peripheral injection of interleukin-1 (IL-1), two types of behavioural tests were chosen, social exploration in mice and schedule-controlled behaviour in rats. Mice treated with 1 and 2.5 micrograms recombinant human IL-1 beta showed a time- and dose-dependent decrease in exploration of a juvenile conspecific. This effect was completely blocked by pretreatment with 10 mg/kg indomethacin or 10 mg/kg piroxicam, but not with 50 mg/kg aspirin. The disruption of operant responding induced by 5 micrograms IL-1 in rats was also suppressed by pretreatment with 5 mg/kg indomethacin or 10 mg/kg piroxicam. These results indicate that prostaglandins mediate the behavioural effects of peripherally injected IL-1.
Crestani
F
F
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U. 259, Université de Bordeaux II, France.
Seguy
F
F
Dantzer
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007267:Injections; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009043:Motor Activity / Q000187:drug effects; D010894:Piroxicam / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D012919:Social Behavior
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D011453:Prostaglandins; D010894:Piroxicam; D007213:Indomethacin