A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient.
The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.
Hoehn-Saric
R
R
Johns Hopkins Medical Institutions Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.
Harris
G J
GJ
Pearlson
G D
GD
Cox
C S
CS
Machlin
S R
SR
Camargo
E E
EE
D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects*; D005625:Frontal Lobe / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
D005473:Fluoxetine