title: Loss of contrast sensitivity in cystic fibrosis.
abstract: We measured the contrast sensitivity function in a 16-year-old boy with cystic fibrosis, before and during vitamin A supplementation. Before vitamin A supplementation, serum levels of vitamin A were abnormally low, the electroretinogram was reduced, and contrast sensitivity was abnormally low at all spatial frequencies. During vitamin A supplementation (25,000 IU/day), serum levels of vitamin A became low normal, the electroretinogram returned to normal, and the overall contrast sensitivity function improved by 94%. We propose that the contrast sensitivity function may be abnormal in patients with cystic fibrosis who have reduced retinal function secondary to vitamin A deficiency.
authors.affiliation: Department of Ophthalmology, Columbus Children's Hospital, Ohio 43205.
authors.forename: L E
authors.initials: LE
authors.lastname: Leguire
authors.forename: K S
authors.initials: KS
authors.lastname: Pappa
authors.forename: M L
authors.initials: ML
authors.lastname: Kachmer
authors.forename: G L
authors.initials: GL
authors.lastname: Rogers
authors.forename: D L
authors.initials: DL
authors.lastname: Bremer
mesh_terms: D000293:Adolescent; D015350:Contrast Sensitivity / Q000502:physiology*; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D008297:Male; D012164:Retinal Diseases / Q000209:etiology / Q000503:physiopathology*; D014801:Vitamin A / Q000097:blood / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000150:complications
chemical_list: D014801:Vitamin A