Organizing multicenter trials: lessons from cardiovascular prevention trials.
Careful and thorough planning are essential aspects of a clinical trial that can make the difference and lead to a more successful trial. The value of feasibility studies should be recognized. The use of surrogate endpoints has justifiably come under increased scrutiny. The many complex issues of implementation demand experienced trial investigators. An openness to learn from lessons in previous trials is essential.
Furberg
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CD
Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005240:Feasibility Studies; D006801:Humans; D015337:Multicenter Studies as Topic / Q000191:economics / Q000379:methods*; D010934:Planning Techniques; D011322:Primary Prevention; D012107:Research Design / Q000592:standards*; D012109:Research Support as Topic / Q000191:economics; D013997:Time Factors