L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination.
Hensens
O D
OD
Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.
Borris
R P
RP
Koupal
L R
LR
Caldwell
C G
CG
Currie
S A
SA
Haidri
A A
AA
Homnick
C F
CF
Honeycutt
S S
SS
Lindenmayer
S M
SM
Schwartz
C D
CD
D002850:Chromatography, Gel; D015936:Complement C5a / Q000037:antagonists & inhibitors*; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism*; D014961:X-Ray Diffraction
D010456:Peptides, Cyclic; C051485:PD 124966; D015936:Complement C5a