title: Does calcium antagonist improve established early ciclosporin nephrotoxicity after renal transplantation?
abstract: We report a case of prolonged oliguric acute renal failure after renal transplantation under steroids and ciclosporin (Cs) immunosuppression. In the 2nd week when low fractional excretion of sodium values in the presence of oliguria (as expression of Cs nephrotoxicity) and high Cs blood levels were seen, a calcium antagonist drug was administered. Also, a Cs dose adjustment was made. Then, the diuresis and fractional excretion of sodium increased together with a progressive renal function. Although this evolution could be explained as a spontaneous resolution of postischemic renal failure, we speculated that in this case of established early Cs nephrotoxicity the effect of a calcium antagonist drug, such as nifedipine, could be beneficial.
authors.affiliation: Department of Nephrology, Hospital 12 de Octubre, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Morales
authors.forename: A
authors.initials: A
authors.lastname: Andres
authors.forename: C
authors.initials: C
authors.lastname: Montoyo
authors.forename: B
authors.initials: B
authors.lastname: Ortuño
authors.forename: J L
authors.initials: JL
authors.lastname: Rodicio
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy*; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
chemical_list: D003524:Cyclosporins; D009543:Nifedipine