Central nervous system action of basic fibroblast growth factor: inhibition of gastric acid and pepsin secretion.
To examine the effects of basic fibroblast growth factor (bFGF) on gastric secretion, the present study was carried out using pylorus-ligated rats. Intracisternally injected bFGF inhibited the secretion of both gastric acid and pepsin, and this gastric antisecretory action of bFGF was a dose-related response. On the other hand, the intraperitoneal injection of bFGF did not change gastric secretion. These results strongly suggested for the first time that bFGF, a growth factor that promotes the proliferation of various cell types, might also be a chemical messenger that is involved in the central regulation of gastric secretion. This biological action of bFGF may be considered as a novel nonmitogenic activity of this growth factor.
Okumura
T
T
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Uehara
A
A
Tsuji
K
K
Taniguchi
Y
Y
Kitamori
S
S
Shibata
Y
Y
Okamura
K
K
Takasugi
Y
Y
Namiki
M
M
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects
D016222:Fibroblast Growth Factor 2; D010434:Pepsin A