[Additive effects of carboplatin (CBDCA) and Co-60 gamma rays in human tumor cells in vitro].
In vitro investigations on the combination effect of radiation and carboplatin (CBDCA) in three human cell lines (HeLa, MRI-186 Caski) show purely additive effects. Study of the molecular lesions gave considerable differences in the time course of repair of radiation induced DNA-double strand-breaks and of formation of DNA-crosslinks by carboplatin. However, sequential treatment with intervals of up to +/- 24 hours resulted also in an additive effect. In the experimental systems studied, a true radiosensitization was not demonstrated.
Flentje
M
M
Radiologische Klinik, Universität Heidelberg.
Latz
D
D
Haner
U
U
Hör
A
A
Trinh
S
S
Wannenmacher
M
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy; D016190:Carboplatin / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D002460:Cell Line; D003037:Cobalt Radioisotopes / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004260:DNA Repair / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006367:HeLa Cells; D006801:Humans; D011838:Radiation-Sensitizing Agents; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy
D003037:Cobalt Radioisotopes; D004273:DNA, Neoplasm; D011838:Radiation-Sensitizing Agents; D016190:Carboplatin