Behavioral effects of chronic, orally administered diuretic and verapamil in baboons.
Behavioral performances of six baboons were tested during chronic oral dosing with diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Reaction times and color matching-to-sample performances as well as physiological measures were obtained in deoxycorticosterone acetate (DOCA)-salt baboons and in renovascular hypertensive baboons. Combined diuretic and verapamil impaired color matching to a small degree in comparison to baseline performance, while drug administered alone had no effect. Weekly systolic and diastolic blood pressures decreased maximally from baseline during the drug combination period, and were accompanied by maximal increases in serum sodium. The largest behavioral impairments during combination dosing were observed for colors that were most difficult to discriminate during baseline. Significant positive correlations were found between systolic blood pressure and color matching accuracy. No differences between the animal hypertension groups were found as a function of drug condition either in physiological or behavioral responses. Only the combination of diuretic and verapamil produced a deleterious effect on color discrimination, which suggests further study of commonly administered drug combination therapies in hypertension.
Turkkan
J S
JS
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Hienz
R D
RD
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D003118:Color Perception / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D004573:Electrolytes / Q000097:blood; D006852:Hydrochlorothiazide / Q000494:pharmacology; D008297:Male; D010215:Papio; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014223:Triamterene / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology*
D004232:Diuretics; D004573:Electrolytes; D006852:Hydrochlorothiazide; D003900:Desoxycorticosterone; D014700:Verapamil; D014223:Triamterene