[Calculation of the radiation-induced delay in cell division during a study of the induction of chromosome aberrations (the theoretical and experimental bases of the approach)].
The possible influence of a radiation-induced delay of cell division on the yield of chromosome aberrations has been analyzed theoretically. The analysis is based on the assumption that the delay is caused by the damages that are realized in the mitosis as chromosome aberrations. It has been shown that the distributions of cells, that are registered by the number of chromosome aberrations, are a function of time of cell fixation and may substantially differ from actual disturbance. There is a correlation between the registered and actual disturbances which is determined by the kinetics of the first mitosis of nonirradiated cells and the degree of the radiation-induced division delay. Some qualitative sequels of the proposed model are in agreement with the experimental data.
Lobachevskiĭ
P N
PN
Fominykh
E V
EV
D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002869:Chromosome Aberrations; D008433:Mathematics; D008722:Methods; D008954:Models, Biological; D011830:Radiation Effects; D012062:Relative Biological Effectiveness; D013997:Time Factors