title: Benzyloxazolidine-2,4-diones as potent hypoglycemic agents.
abstract: A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.
authors.affiliation: Central Research Division, Pfizer Incorporated, Groton, Connecticut 06340.
authors.forename: R L
authors.initials: RL
authors.lastname: Dow
authors.forename: B M
authors.initials: BM
authors.lastname: Bechle
authors.forename: T T
authors.initials: TT
authors.lastname: Chou
authors.forename: D A
authors.initials: DA
authors.lastname: Clark
authors.forename: B
authors.initials: B
authors.lastname: Hulin
authors.forename: R W
authors.initials: RW
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D008820:Mice, Obese; D010080:Oxazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010080:Oxazoles