Plasma endothelin levels during myocardial ischemia and reperfusion.
Endothelin, an endothelium-derived vasoconstrictive peptide, has a strong potency of coronary artery constriction. However, the role of endogeneous endothelin under pathophysiological conditions has not yet been known. In this study, we examined plasma endothelin concentration in dogs with myocardial ischemia and reperfusion. Anesthetized open-chest dogs underwent either 45 minutes occlusion of the left anterior descending coronary artery followed by 3 hours reperfusion, or 4-10 hours of continuous occlusion. Plasma concentration of endothelin from the central vein was measured by the highly sensitive enzyme-immunoassay. Plasma endothelin concentration increased 2.2-fold with the peak level at 60 minutes after release of the ligated artery, but occlusion per se caused no remarkable change. These data suggest that reperfusion of the occluded artery might be needed to increase the plasma concentration of endothelin in case of myocardial infarction.
Tsuji
S
S
Third Department of Internal Medicine, Osaka University Medical School, Japan.
Sawamura
A
A
Watanabe
H
H
Takihara
K
K
Park
S E
SE
Azuma
J
J
D000818:Animals; D003327:Coronary Disease / Q000097:blood*; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D016232:Endothelins / Q000097:blood*; D005260:Female; D008297:Male; D015425:Myocardial Reperfusion; D013997:Time Factors
D016232:Endothelins