Humoral immunity against tick-borne encephalitis virus following manifest disease and active immunization.
Humoral immunity against tick-borne encephalitis virus (TBEV) in patients with a well-documented history of naturally acquired tick-borne encephalitis (TBE) was compared with immunity resulting from vaccination in a carefully controlled immunization programme. The vaccination study was performed with a highly purified, inactivated virus particle vaccine and the immune response was followed by tracing the course of IgG antibody formation in an enzyme-linked immunosorbent assay and a neutralization assay. It was shown that this TBE vaccine induced a strong immune response. TBE IgG antibody titres measured after three vaccinations were of the same order of magnitude as those determined in patients recovered from manifest TBE.
Klockmann
U
U
Behringwerke AG, Marburg, FRG.
Bock
H L
HL
Kwasny
H
H
Praus
M
M
Cihlová
V
V
Tomková
E
E
Krivanec
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000008:administration & dosage / Q000494:pharmacology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014765:Viral Vaccines