Studies in phlebitis: detection and quantitation using a thermographic camera.
A new method for the detection of acute phlebitis in superficial veins is investigated. A thermographic camera is utilized for the quantitation of temperature changes in a rabbit ear model. A control group receiving no injection is compared against each of five treatment groups receiving these commercially available parenterals: amiodarone hydrochloride, phenytoin sodium, mechlorethamine hydrochloride, cephalothin sodium, and diazepam. The vehicles of the above-mentioned drugs as well as several commonly used organic cosolvents are also investigated. Local tissue responses to the parenteral challenges are measured and a good correlation between the visual and the thermographic data was seen.
Ward
G H
GH
Department of Pharmaceutical Science, College of Pharmacy, University of Arizona, Tucson 85715.
Nolan
P E
PE
Chawla
M
M
Yalkowsky
S H
SH
D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D004431:Ear, External / Q000473:pathology; D007267:Injections; D014677:Pharmaceutical Vehicles / Q000009:adverse effects; D010689:Phlebitis / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D010781:Photography; D011817:Rabbits; D013817:Thermography
D014677:Pharmaceutical Vehicles