Role of monoamine oxidase in aminopropionitrile-induced neurotoxicity.
Oxidation of aminopropionitriles was measured in vitro with both rat liver mitochondria and bovine plasma monoamine oxidase (MAO). The nonneurotoxic aminonitrile beta-aminopropionitrile (BAPN) was oxidized at a significantly higher rate (p less than .05) than either of the neurotoxic aminonitriles tested; 3,3'-iminodipropionitrile (IDPN) and 3,3'-dimethylaminopropionitrile (DMAPN). DMAPN was a poor substrate for both mitochondrial and plasma MAO. None of the aminonitriles tested were found to inhibit MAO activity in rat brain or liver in vivo. Inhibition of MAO activity with pargyline in vivo did not affect the pattern of IDPN- or DMAPN-induced toxicity. These results suggest that monoamine oxidase is not involved in aminonitrile-induced neurotoxicity.
Wilmarth
K R
KR
Department of Environmental Health Sciences, School of Public Health, University of California, Los Angeles 90024.
Froines
J R
JR
D000629:Aminopropionitrile / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000201:enzymology; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000097:blood / Q000378:metabolism*; D009420:Nervous System / Q000187:drug effects*; D009570:Nitriles / Q000378:metabolism / Q000633:toxicity; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects
D009570:Nitriles; D000629:Aminopropionitrile; C019348:dimethylaminopropionitrile; D006861:Hydrogen Peroxide; D008995:Monoamine Oxidase