title: Vitamin D analogs inhibit erythroid differentiation and induce monocytic differentiation of leukemic cells with the same relative potency.
abstract: Myeloid leukemia cells of human and murine origin can be induced to differentiate into more mature forms which lose their neoplastic properties. The hormonal form of vitamin D is a powerful inducer of monocytic differentiation, but its therapeutic use is limited by hypercalcemia. It was recently reported that a novel derivative of vitamin D, 1,25-dihydroxy-16-ene-23-yne-vitamin D3, is an exceptionally potent inducer of monocytic differentiation, and prolongs survival of mice bearing leukemia cells. We now show that this compound is also a most potent inhibitor of erythrodifferentiation. This finding has important implications for the control of hematopoiesis.
authors.affiliation: Department of Laboratory Medicine & Pathology, UMD-New Jersey Medical School, Newark 07103.
authors.forename: S S
authors.initials: SS
authors.lastname: Kolla
authors.forename: D C
authors.initials: DC
authors.lastname: Moore
authors.forename: G P
authors.initials: GP
authors.lastname: Studzinski
mesh_terms: D002117:Calcitriol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014807:Vitamin D / Q000031:analogs & derivatives*
chemical_list: D014807:Vitamin D; D002117:Calcitriol; C064183:Ro 23-7553