title: K+ channel properties in cultured mouse Schwann cells: dependence on extracellular K+.
abstract: In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the threshold of current activation was shifted to more negative potentials. This shift in the activation threshold was only observed with normal (50-60 mM) intracellular [K+] levels; it was not apparent when [K+]i was elevated to 145 mM. The control of [K+]o on the gating properties of K+ channels may serve to enhance the capability of the Schwann cell to take up [K+]o and thus may serve for [K+] homeostasis in the peripheral nerve.
authors.affiliation: Department of Neurobiology, University of Heidelberg, West Germany.
authors.forename: A
authors.initials: A
authors.lastname: Verkhratsky
authors.forename: D
authors.initials: D
authors.lastname: Hoppe
authors.forename: H
authors.initials: H
authors.lastname: Kettenmann
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004553:Electric Conductivity; D004594:Electrophysiology; D005110:Extracellular Space / Q000378:metabolism*; D006706:Homeostasis; D051379:Mice; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000502:physiology*; D012583:Schwann Cells / Q000378:metabolism*
chemical_list: D015221:Potassium Channels; D011188:Potassium