Domperidone-induced acute dystonia and polycystic ovary syndrome.
The occurrence of acute dystonic reactions (ADRs) due to domperidone administration in two young women is reported. In both patients, a typical polycystic ovary (PCO) syndrome was found. The possibility that the relative hyperestrogenism typical of PCO syndrome acted as a facilitating factor for ADR is discussed.
Bonuccelli
U
U
Institute of Clinical Neurology, University of Pisa, Italy.
Nocchiero
A
A
Napolitano
A
A
Paoletti
A M
AM
Melis
G B
GB
Corsini
G U
GU
Muratorio
A
A
D000293:Adolescent; D000328:Adult; D004294:Domperidone / Q000008:administration & dosage / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000097:blood / Q000209:etiology*; D004421:Dystonia / Q000097:blood / Q000139:chemically induced*; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D009325:Nausea / Q000097:blood / Q000188:drug therapy*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D014839:Vomiting / Q000097:blood / Q000188:drug therapy*
D004967:Estrogens; D004294:Domperidone