Suppressive effect of sulfate on the development of hypertension in DOCA-salt hypertensive rats.
The purpose of this study was to examine the effect of the sulfate ion on blood pressure in DOCA-salt hypertension, which involves increased sympathetic nervous activity. Male Wistar rats were divided into four groups, and received one of the following drinking solutions: distilled water [control], 171 mmol/L sodium chloride [NaCl group], 171 mmol/L sodium chloride plus 12 mmol/L magnesium sulfate [S(+) group], or 171 mmol/L sodium chloride plus 12 mmol/L magnesium chloride [S(-) group]. In the S(+) group, the elevation of systolic blood pressure (SBP; mm Hg) was significantly attenuated (168 +/- 17 v 213 +/- 26, P less than .005) and intraerythrocyte calcium concentration (R-Ca; mumol/L cells) was significantly lower (11.5 +/- 3.0 v 17.4 +/- 6.5, P less than .05) than in the S(-) group. The cardiac norepinephrine content (H-NE; ng/100 g tissue) of the S(+) group was significantly lower than that of the S(-) group. SBP was correlated negatively with H-NE (r = -0.70, P less than .001) and positively with R-Ca (r = 0.45, P less than .005). R-Ca was negatively correlated with H-NE (r = -0.36, P less than .05). These results suggest that the replacement of chloride with sulfate ion suppresses the development of hypertension in DOCA-salt rats at least in part by its inhibitory effect on sympathetic nervous activity through the decreased intracellular calcium concentration.
Kubota
Y
Y
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
Sano
H
H
Kawahara
J
J
Hattori
K
K
Miki
T
T
Suzuki
H
H
Fukuzaki
H
H
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D003900:Desoxycorticosterone; D004912:Erythrocytes / Q000378:metabolism; D006973:Hypertension / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D015636:Magnesium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013431:Sulfates / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects
D013431:Sulfates; D015636:Magnesium Chloride; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D008278:Magnesium Sulfate; D002118:Calcium; D009638:Norepinephrine