Effect of acidosis on lipid peroxidation in brain slices.
Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes. These results support the hypothesis that free radical mechanisms may be involved in the cytotoxicity of acidosis.
Bralet
J
J
Laboratoire de Pharmacodynamie et Physiologie pharmaceutique, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
Bouvier
C
C
Schreiber
L
L
Boquillon
M
M
D000138:Acidosis / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D007773:Lactates / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D010710:Phosphates