[A dose-effect relationship study for the frequency of binuclear cells with micronuclei in a human lymphocyte culture after gamma irradiation].
The method of the cytokinetic blocking was used to determine, in 18 healthy male donors aged 21-35 years, the frequency of binuclear cells with micronuclei that amounted to 1.1 +/- 0.2% (0.3-2.4%) on the average. The dependence of this parameter upon radiation dose (60Co-gamma radiation, 0.05 to 2 Gy) was a linear quadratic function and was described by the following regression equation: Yx = 0.76 + 5.76 D +/- 2.61 D2. With a dose of 0.05 Gy the frequency of binuclear cells with micronuclei exceeded significantly the control level.
Ankina
M A
MA
Mikhaĭlova
G F
GF
D000328:Adult; D002467:Cell Nucleus / Q000528:radiation effects* / Q000648:ultrastructure; D002478:Cells, Cultured / Q000528:radiation effects / Q000648:ultrastructure; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects* / Q000648:ultrastructure; D015162:Micronucleus Tests; D012044:Regression Analysis