title: Effects of halothane on hypoxic pulmonary vasoconstriction in canine atelectasis.
abstract: We studied the interactions of atelectasis and halothane on hypoxic pulmonary vasoconstriction using an isolated canine lobe. We divided pulmonary vascular resistance into arterial, venous, and middle segmental resistances by a vascular occlusion technique. We found that middle segmental resistance significantly increased (P less than 0.05) from 0.016 +/- 0.007 cm H2O.mL-1.min-1 during normoxic ventilation to 0.06 +/- 0.007 cm H2O.mL-1.min-1 during hypoxic ventilation. We then produced sublobar atelectasis by introducing 4.5-mm steel ball bearings into the lobar bronchus, which resulted in a significant increase (P less than 0.05) of middle segmental resistance to 0.046 +/- 0.014 cm H2O.mL-1.min-1 during normoxic ventilation and a further significant increase (P less than 0.05) to 0.084 +/- 0.02 cm H2O.mL-1.min-1 during hypoxic ventilation. Ventilation with 2.0% halothane but not 0.5% halothane prevented the increases in middle segmental resistance observed with either atelectasis or hypoxic ventilation. Values of arterial and venous segmental resistances were not similarly affected. We conclude that sublobar atelectasis increases pulmonary vascular resistance by stimulating hypoxic pulmonary vasoconstriction. Both halothane and hypoxia primarily act upon the middle vascular segment, but their effects are in opposite directions and, in the former instance, are concentration-dependent.
authors.affiliation: Department of Anaesthesia, University of Saskatchewan, Saskatoon, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Johnson
authors.forename: T S
authors.initials: TS
authors.lastname: Hurst
authors.forename: I
authors.initials: I
authors.lastname: Mayers
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004285:Dogs; D006221:Halothane / Q000633:toxicity*; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism*; D008168:Lung / Q000098:blood supply* / Q000187:drug effects; D001261:Pulmonary Atelectasis / Q000378:metabolism*; D011659:Pulmonary Gas Exchange; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction
chemical_list: D006221:Halothane