title: Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders.
abstract: A human tryptophan oxygenase clone was isolated by screening a liver cDNA library with a rat tryptophan oxygenase cDNA clone. Analysis showed extensive homology between the rat and the human DNA and protein sequences. The combined use of cell hybrids and in situ hydridization indicated that human tryptophan oxygenase was localized to chromosome band 4q31. The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism.
authors.affiliation: Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91010.
authors.forename: D E
authors.initials: DE
authors.lastname: Comings
authors.forename: D
authors.initials: D
authors.lastname: Muhleman
authors.forename: G W
authors.initials: GW
authors.lastname: Dietz
authors.forename: T
authors.initials: T
authors.lastname: Donlon
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D003001:Cloning, Molecular; D004247:DNA; D004270:DNA, Circular / Q000235:genetics; D005796:Genes; D005824:Genetics, Behavioral; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D014366:Tryptophan Oxygenase / Q000235:genetics*
chemical_list: D004270:DNA, Circular; D012333:RNA, Messenger; D004247:DNA; D014366:Tryptophan Oxygenase