PAF-acether in AK-5 tumour cells.
PAF-Acether fraction derived from stimulated AK-5 tumour cells, aggregated human platelets. The platelet aggregating ability increased linearly with increasing concentration of the stimulant, calcium ionophore A23187, and reached a maximum at 6 microM in 25 minutes. This factor had biological and chemical properties identical to authentic PAF-acether. Our results demonstrate that, although PAF-acether is produced mainly from pro-inflammatory cells, it appears to be produced even in tumour cells.
Marathe
G K
GK
Department of Studies in Biochemistry, University of Mysore, India.
Krishnakantha
T P
TP
D'Souza
C J
CJ
D000818:Animals; D004224:Diterpenes; D005350:Fibroma / Q000378:metabolism*; D046934:Ginkgolides; D006801:Humans; D007783:Lactones / Q000494:pharmacology; D010740:Phospholipases / Q000378:metabolism; D010972:Platelet Activating Factor / Q000032:analysis / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000494:pharmacology; D010974:Platelet Aggregation; D014407:Tumor Cells, Cultured
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B; D010740:Phospholipases