title: Wound healing and infection in pretibial lacerations.
abstract: Eighty-eight patients with pretibial lacerations were entered into a study to analyze bacteriological and wound-healing profiles. Fifty-four patients were followed to complete wound healing. A complete photographic record of wounds from time of presentation to healing was available for analysis in 49 of these patients. Staphylococcus aureus was the most common pathogen, but the correlation between clinical wound infection and growth of pathogenic bacteria was poor. Flucloxacillin alone was found to be significantly more effective in controlling wound infection than in combination with metronidazole. Computerized image analysis of the photographic records was performed. There was no significant difference in the healing times of the various classic surgical wound types, and image analysis confirmed that the rates of wound healing were generally similar in all the types of pretibial wounds.
authors.affiliation: St Stephen's Hospital, London, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Warren
authors.forename: M A
authors.initials: MA
authors.lastname: Warren
authors.forename: W A
authors.initials: WA
authors.lastname: Buswell
authors.forename: D C
authors.initials: DC
authors.lastname: Shanson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D007869:Leg Injuries / Q000382:microbiology* / Q000503:physiopathology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D010781:Photography; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013977:Tibia; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D008795:Metronidazole; D005436:Floxacillin