Elevation of serum progesterone with oral micronized progesterone after in vitro fertilization. A randomized, controlled trial.
In a randomized, controlled trial, oral micronized progesterone (P4) supplementation effectively elevated luteal phase serum P4 levels after in vitro fertilization (IVF). Of 34 nonconception IVF cycles, 12 were supplemented with oral micronized P4, 200 mg four times daily, beginning the day of oocyte retrieval, while 22 control cycles did not receive supplementation. With oral micronized P4 supplementation the P4 levels were higher (P less than .001) and the luteal phase longer (P less than .05). Oral micronized P4 supplementation appears to be a convenient method of supporting serum P4 levels during the luteal phase after IVF.
Colwell
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Department of Gynaecology and Reproductive Medicine, University Hospital, London, Ontario, Canada.
Tummon
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D000284:Administration, Oral; D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008183:Luteal Phase; D011247:Pregnancy; D011374:Progesterone / Q000097:blood* / Q000627:therapeutic use*
D011374:Progesterone