Rhabdomyolysis after intramuscular iron-dextran in malabsorption.
The case of a 59 year old white man who had chronic malabsorption and selective IgA deficiency with severe iron deficiency is reported. In addition, he was deficient in vitamin E and selenium, important antioxidants which protect against lipid peroxidation. He was intolerant of oral iron and when treated with iron-dextran developed symptoms suggestive of polymyositis with evidence of rhabdomyolysis. It is suggested that free iron within iron-dextran activated free radicals, initiating lipid peroxidation and leading to polymyositis, rhabdomyolysis, and myoglobulinuria.
Foulkes
W D
WD
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Sewry
C
C
Calam
J
J
Hodgson
H J
HJ
D000747:Anemia, Hypochromic / Q000150:complications; D004406:Dysgammaglobulinemia / Q000150:complications; D006801:Humans; D017098:IgA Deficiency; D007505:Iron-Dextran Complex / Q000009:adverse effects*; D008286:Malabsorption Syndromes / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D012206:Rhabdomyolysis / Q000209:etiology* / Q000473:pathology; D012643:Selenium / Q000172:deficiency; D014811:Vitamin E Deficiency / Q000150:complications
D007505:Iron-Dextran Complex; D012643:Selenium