Cell-cell interactions and erythropoiesis.
The erythroblastic island, a distinct anatomical unit consisting of a central macrophage surrounded by a ring of erythroblasts, is a key feature of erythropoiesis in the bone marrow. While a number of functional sequelae for the interaction between the erythroblasts and macrophage have been suggested, much remains to be learned. We suggest that this interaction may play a role in regulated assembly of membrane proteins during erythroid differentiation.
Mohandas
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Division of Cell and Molecular Biology, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
D002450:Cell Communication / Q000502:physiology*; D004900:Erythroblasts / Q000166:cytology; D004920:Erythropoiesis / Q000502:physiology*; D006801:Humans