N-[1-(2-thienyl)cyclohexyl]-piperidine (TCP) does not block kainic acid-induced status epilepticus but reduces secondary hippocampal damage.
Distant damage, localized in the CA3 and CA1 areas, was observed in the hippocampus of rats as a consequence of status epilepticus (SE) induced by the injection of 2.5 nmol of kainic acid (KA) into the amygdala. In animals pretreated with an intraperitoneal injection of the non-competitive antagonist of the N-methyl-D-aspartate receptor, N-[1-(2-thienyl)cyclohexyl]-piperidine (TCP) (20 mg/kg), distant neuronal damage was reduced (CA1 neurons were always spared) whereas the rats still developed SE with an earlier onset. These results demonstrate the protective effect of TCP and confirm that epileptic activity and brain damage may be dissociated by NMDA receptor antagonists.
Lerner-Natoli
M
M
CNRS UPR41, INSERM U249, Laboratoire de Médecine Expérimentale, Institut de Biologie, Montpellier, France.
Rondouin
G
G
Belaidi
M
M
Baldy-Moulinier
M
M
Kamenka
J M
JM
D000818:Animals; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011712:Pyramidal Tracts / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
C012058:tenocyclidine; D010622:Phencyclidine; D007608:Kainic Acid