Degenerate Hopf bifurcation and isolated periodic solutions of the Hodgkin-Huxley model with varying sodium ion concentration.
Points of degenerate Hopf bifurcation in the Hodgkin-Huxley model are found as parameters temperature T and voltage level of sodium VNa are varied. Local techniques of degenerate Hopf bifurcation analysis are used to show the existence of families of periodic solutions of the model: isolated branches of periodic solutions (i.e. branches not connected to the stationary branch) are found in addition to Hopf branches. Purely numerical techniques are used to show that the isolas persist for VNa up to a value slightly greater than 114 mV. Under some conditions there are multiple stable periodic solutions, so "jumping" between action potentials of different amplitudes might be observed.
Shiau
L J
LJ
Department of Mathematics, State University of New York, Buffalo 14214.
Hassard
B
B
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D008432:Mathematical Computing; D008954:Models, Biological; D012964:Sodium / Q000378:metabolism*; D013696:Temperature
D012964:Sodium