title: Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity.
abstract: Oct-1 and a second, previously unidentified octamer-binding protein (Oct-R) have been identified in extracts of Xenopus laevis oocytes and embryos. Oct-1 does not bind to the octamer motif associated with certain Xenopus laevis histone H2B gene promoters, whereas Oct-R binds well to this motif, but only in the sequence context of the H2B gene promoter.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry, UK.
authors.forename: D P
authors.initials: DP
authors.lastname: Smith
authors.forename: R W
authors.initials: RW
authors.lastname: Old
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001667:Binding, Competitive; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006657:Histones / Q000235:genetics*; D051863:Host Cell Factor C1; D051379:Mice; D008969:Molecular Sequence Data; D050811:Octamer Transcription Factor-1; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism*; D029867:Xenopus Proteins; D014982:Xenopus laevis
chemical_list: D004268:DNA-Binding Proteins; C497693:Hcfc1 protein, mouse; D006657:Histones; D051863:Host Cell Factor C1; C068351:Oct-R protein, Xenopus; D050811:Octamer Transcription Factor-1; C494169:POU2F1 protein, Xenopus; C494166:Pou2f1 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins