title: Nature of the endogenous pyrogen (EP) induced by influenza viruses: lack of correlation between EP levels and content of the known pyrogenic cytokines, interleukin 1, interleukin 6 and tumour necrosis factor.
abstract: Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret of human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines.
authors.affiliation: Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences, University of Birmingham, U.K.
authors.forename: K J
authors.initials: KJ
authors.lastname: Jakeman
authors.forename: C R
authors.initials: CR
authors.lastname: Bird
authors.forename: R
authors.initials: R
authors.lastname: Thorpe
authors.forename: H
authors.initials: H
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Sweet
mesh_terms: D000818:Animals; D001681:Biological Assay; D005289:Ferrets; D005334:Fever / Q000209:etiology; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000502:physiology; D015850:Interleukin-6 / Q000096:biosynthesis / Q000502:physiology; D007962:Leukocytes / Q000276:immunology*; D009975:Orthomyxoviridae / Q000502:physiology*; D009976:Orthomyxoviridae Infections / Q000378:metabolism; D011749:Pyrogens / Q000096:biosynthesis* / Q000502:physiology; D013010:Sonication; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000502:physiology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D011749:Pyrogens; D014409:Tumor Necrosis Factor-alpha; C008270:leukocyte endogenous mediator