Multiple comparisons in over-the-counter drug clinical trials with both positive and placebo controls.
Evaluations of the efficacy of over-the-counter drugs using ANOVA techniques often misuse multiple comparison procedures. Studies that involve both a placebo control and established drugs as positive controls are especially prone to these problems. The most common mistake involves using a procedure which does not control the experimentwise type I error rate, usually the Duncan procedure or some version of multiple t tests. These procedures control comparisonwise type I error rate, but lack the important experimentwise error control. The purpose of this paper is to clarify the issues involved in performing ANOVA followed by a multiple comparison procedure for over-the-counter drug studies involving both placebo and positive controls.
D'Agostino
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Department of Mathematics, Boston University, MA 02215.
Heeren
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TC
D000704:Analysis of Variance; D015982:Bias; D002986:Clinical Trials as Topic / Q000379:methods*; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods; D004366:Nonprescription Drugs / Q000627:therapeutic use*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012107:Research Design; D012680:Sensitivity and Specificity
D004366:Nonprescription Drugs; D010919:Placebos