title: Bone scans in the diagnosis of bone crisis in patients who have Gaucher disease.
abstract: Of thirty-four occurrences of bone pain in seventeen children and young adults who had type-I Gaucher disease, twenty-five were finally diagnosed as bone crises. On the basis of a bone scan with technetium-99m methylene diphosphonate, a correct diagnosis of bone crisis was made for twenty-three occurrences, with a sensitivity of 0.92. At the onset of a crisis, the bone scan typically showed decreased uptake of radionuclide at the involved site. After six weeks, a repeat bone scan of the long bones showed a ring of increased uptake surrounding an area of decreased uptake. At six months, the appearance of the bones on the radionuclide scan was normal.
authors.affiliation: Department of Orthopedic Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: K
authors.initials: K
authors.lastname: Katz
authors.forename: S
authors.initials: S
authors.lastname: Mechlis-Frish
authors.forename: I J
authors.initials: IJ
authors.lastname: Cohen
authors.forename: G
authors.initials: G
authors.lastname: Horev
authors.forename: R
authors.initials: R
authors.lastname: Zaizov
authors.forename: E
authors.initials: E
authors.lastname: Lubin
mesh_terms: D000293:Adolescent; D000328:Adult; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002648:Child; D005260:Female; D005269:Femur; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D006811:Humerus; D008297:Male; D010146:Pain / Q000209:etiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011859:Radiography; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D013904:Thoracic Vertebrae; D013977:Tibia
chemical_list: D013669:Technetium Tc 99m Medronate