[The role of "valine substitution" in oncogene functioning (a hypothesis)].
A hypothesis presented in the paper discusses the role of valine substitution in p21 protein of H-ras, a product of ras family oncogene. The event was followed by a marked decrease in GTPase activity of the protein and alteration of its function in the cell. Recent results of X-ray structural analysis were compared with the model suggested by the authors earlier. The role of valine substitution in sickle-cell anemia held to be a genetic mechanism of protection against malaria is discussed. Based on similarity of valine substitution in p21 protein and hemoglobin, a relationship between certain forms of malignant transformation and malaria at molecular level is suggested.
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D000755:Anemia, Sickle Cell / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000378:metabolism; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism; D015689:Oncogene Protein p21(ras) / Q000378:metabolism; D009857:Oncogenes / Q000502:physiology*; D010442:Peptide Chain Initiation, Translational / Q000502:physiology; D010443:Peptide Chain Termination, Translational / Q000502:physiology; D014633:Valine / Q000378:metabolism*; D014961:X-Ray Diffraction
D020558:GTP Phosphohydrolases; D015689:Oncogene Protein p21(ras); D014633:Valine