title: Pre-morbid adjustment and personality in psychosis. Effects of sex and diagnosis.
abstract: Pre-morbid schizoid and schizotypal traits and social adjustment were assessed blind to diagnosis by interviewing the mothers of 73 consecutively admitted patients with DSM-III schizophrenia or affective psychosis. Analysis of factors associated with pre-morbid deficits showed a highly significant interaction of diagnosis with sex, such that schizophrenic men showed much greater pre-morbid impairment than either schizophrenic women or men with affective disorder. Poor pre-morbid adjustment predicted an early age at first admission. The results can be explained by a neurodevelopmental disorder in some schizophrenic males.
authors.affiliation: National Institutes of Mental Health, Bethesda, Maryland.
authors.forename: A
authors.initials: A
authors.lastname: Foerster
authors.forename: S
authors.initials: S
authors.lastname: Lewis
authors.forename: M
authors.initials: M
authors.lastname: Owen
authors.forename: R
authors.initials: R
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000175:diagnosis* / Q000209:etiology; D000367:Age Factors; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009034:Mother-Child Relations; D009422:Nervous System Diseases / Q000150:complications / Q000453:epidemiology; D012189:Retrospective Studies; D012557:Schizoid Personality Disorder / Q000175:diagnosis / Q000453:epidemiology*; D012559:Schizophrenia / Q000175:diagnosis* / Q000209:etiology; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000453:epidemiology*; D012737:Sex Factors; D012917:Social Adjustment