title: MK-507 versus sezolamide. Comparative efficacy of two topically active carbonic anhydrase inhibitors.
abstract: Topical carbonic anhydrase inhibitors MK-507 and sezolamide hydrochloride (previously known as MK-417) were compared in a double-masked, randomized, placebo-controlled study in 82 patients with bilateral primary open-angle glaucoma or ocular hypertension. MK-507 was given every 8 or 12 hours, sezolamide every 8 hours, or placebo every 8 or 12 hours for 4 days. Both drugs lowered intraocular pressure (IOP) substantially. MK-507 was somewhat more active than sezolamide, with a peak mean IOP reduction of 26.2% for MK-507 versus 22.5% for sezolamide, although the difference between the treatments was not statistically significant. These drugs may have potential in the treatment of glaucoma.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Clinical Research and Biostatistics, West Point, PA 19486.
authors.forename: E A
authors.initials: EA
authors.lastname: Lippa
authors.forename: J S
authors.initials: JS
authors.lastname: Schuman
authors.forename: E J
authors.initials: EJ
authors.lastname: Higginbotham
authors.forename: M A
authors.initials: MA
authors.lastname: Kass
authors.forename: R N
authors.initials: RN
authors.lastname: Weinreb
authors.forename: G L
authors.initials: GL
authors.lastname: Skuta
authors.forename: D L
authors.initials: DL
authors.lastname: Epstein
authors.forename: B
authors.initials: B
authors.lastname: Shaw
authors.forename: D J
authors.initials: DJ
authors.lastname: Holder
authors.forename: D A
authors.initials: DA
authors.lastname: Deasy
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide; C057921:sezolamide