title: N2-glucuronidation and N4-acetylation of sulphaphenazole by the turtle Pseudemys scripta elegans.
abstract: After an oral dose of 100 mg of sulphaphenazole, the turtle Pseudemys scripta elegans excretes 27% of the compound unchanged and 3.8% as N4-acetylsulphaphenazole. The expected glucuronide conjugate, sulphaphenazole-N2-glucuronide, is not formed and excreted.
authors.affiliation: Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
authors.forename: M L
authors.initials: ML
authors.lastname: Vree
authors.forename: N
authors.initials: N
authors.lastname: Benneken Kolmer
authors.forename: Y A
authors.initials: YA
authors.lastname: Hekster
authors.forename: M
authors.initials: M
authors.lastname: Shimoda
mesh_terms: D000107:Acetylation; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005965:Glucuronates / Q000378:metabolism*; D013426:Sulfaphenazole / Q000378:metabolism / Q000493:pharmacokinetics*; D014426:Turtles / Q000378:metabolism*
chemical_list: D005965:Glucuronates; D013426:Sulfaphenazole