[Hypoxic-ischemic brain damage: detection of early stage].
The type of hypoxic-ischemic brain damage is determined by the distribution of lesions, which has different mechanism in each. Neuroimaging is important for detection of the lesions, but morphological changes appear 12 hours after hypoxic episodes even in neuropathology. Hemodynamic, biochemical and neurophysiological changes during the acute stage are also valuable for earlier diagnosis of the lesions. Doppler sonography and near-infrared spectroscopy, reflected intracranial hemodynamics and metabolism. In our clinicopathological studies, the infants with pontosubicular necrosis showed significantly high incidence in severe hypocarbia, which may be associated with hypoperfusion. Thus, the monitoring of brain hemodynamics and metabolism may be important for early treatment as well as prevention of the brain damage.
Takashima
S
S
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo.
Houdou
S
S
Hasegawa
M
M
Hashimoto
K
K
Takeuchi
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood; D011817:Rabbits
D010100:Oxygen