Peutz-Jeghers-like melanotic macules associated with esophageal adenocarcinoma.
A 67-year-old white man with esophageal adenocarcinoma presented with Peutz-Jeghers-like macules on the lips, face, nipples, and rectal mucosa. Pathological examination of the macules showed atypical melanocytes in the epidermis. The pleomorphic large melanocytes resembled the neoplastic cells seen in melanoma in situ. This is the first report of proliferation of atypical melanocytes in Peutz-Jeghers-like melanosis associated with a primary esophageal adenocarcinoma.
Eng
A
A
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153.
Armin
A
A
Massa
M
M
Gradini
R
R
D000230:Adenocarcinoma; D001004:Anus Diseases / Q000473:pathology; D004938:Esophageal Neoplasms; D005148:Facial Dermatoses / Q000473:pathology; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008548:Melanosis / Q000473:pathology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology; D009558:Nipples / Q000473:pathology; D010580:Peutz-Jeghers Syndrome / Q000473:pathology*