Cytoprotective activity of pectic polysaccharides from the root of panax ginseng.
An acidic polysaccharide fraction, GRA-4, of the root extract of Panax ginseng, when administered from 50 to 200 mg/kg orally, inhibited gastric lesions induced by HCl-ethanol or absolute ethanol, in a dose-dependent manner. The cytoprotective activity of GRA-4 decreased after its treatment with periodate but not after protein digestion, indicating that the carbohydrate moiety of this acidic polysaccharide contributes to this activity.
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Oriental Medicine Research Center, Kitasato Institute, Tokyo, Japan.
Matsumoto
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Kiyohara
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Hirano
M
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Yamada
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H
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D005894:Panax; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D011134:Polysaccharides; D000431:Ethanol