Bioavailability and pharmacokinetics of ofloxacin in healthy volunteers.
The pharmacokinetics and bioavailability of ofloxacin in 20 healthy male volunteers were studied in an open-label, randomized, two-way crossover study. Ofloxacin (400 mg) was administered either as a 1-h infusion or as an oral tablet. The mean peak concentration after intravenous infusion was 4.30 +/- 0.69 microgram/ml, and that after oral administration was 3.14 +/- 0.53 microgram/ml, occurring 1.74 +/- 0.57 h after dosing. The bioavailability (F) of the oral dosage form of ofloxacin was virtually identical to that of the intravenous form (F = 105% +/- 7%). This complete bioavailability of ofloxacin is supportive of the use of the oral dosage form for the treatment of infections in hospitalized patients either as a replacement for intravenous ofloxacin therapy or in streamlining therapy from the intravenous to the oral route.
Yuk
J H
JH
Pharmacy Services, Methodist Hospital, Houston, Texas 77030.
Nightingale
C H
CH
Quintiliani
R
R
Sweeney
K R
KR
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation
D015242:Ofloxacin