Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.
Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.
Nerenberg
M I
MI
Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Minor
T
T
Price
J
J
Ernst
D N
DN
Shinohara
T
T
Schwarz
H
H
D000818:Animals; D001483:Base Sequence; D015870:Gene Expression; D016355:Genes, pX; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013601:T-Lymphocytes / Q000382:microbiology*; D014170:Transformation, Genetic; D014407:Tumor Cells, Cultured