title: Electroencephalographic changes associated with bromethalin toxicosis in the dog.
abstract: Electroencephalogram (EEG) recordings were obtained before and during the clinical syndrome induced by a bromethalin rodenticide given to dogs. Nine dogs given 6.25 mg bromethalin/kg po developed clinical signs and EEG abnormalities 15 to 58 h postdosing. Predominant abnormal EEG changes included spike and spike-and-wave EEG patterns (66%), high voltage slow wave (HVSA, 50-150 microV, 1-6 Hz) activity (44%) photoconvulsive or photoparoxysmal irritative responses (44%), and marked voltage depression (dominant activity less than 10 microV) in all leads (33%).
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors.forename: D C
authors.initials: DC
authors.lastname: Dorman
authors.forename: A J
authors.initials: AJ
authors.lastname: Parker
authors.forename: W B
authors.initials: WB
authors.lastname: Buck
mesh_terms: D000814:Aniline Compounds / Q000009:adverse effects*; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000662:veterinary*; D001931:Brain Mapping; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004569:Electroencephalography; D012378:Rodenticides / Q000009:adverse effects*
chemical_list: D000814:Aniline Compounds; D012378:Rodenticides; C040307:bromethalin