title: Is there a link between fluoridated water and osteosarcoma?
abstract: To test the hypothesis that fluoride is a risk factor for osteosarcoma, a case control study compared the complete residential fluoride histories of osteosarcoma patients with matched hospital-based controls. Fluoridation was not found to be a risk factor for osteosarcoma in the study population. The trend in the data from this small sample study suggests the hypothesis that a protective effect may exist against the formation of osteosarcoma for individuals consuming fluoridated water.
authors.affiliation: Harvard School of Dental Medicine, Boston.
authors.forename: S M
authors.initials: SM
authors.lastname: McGuire
authors.forename: E D
authors.initials: ED
authors.lastname: Vanable
authors.forename: M H
authors.initials: MH
authors.lastname: McGuire
authors.forename: J A
authors.initials: JA
authors.lastname: Buckwalter
authors.forename: C W
authors.initials: CW
authors.lastname: Douglass
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D005457:Fluoridation / Q000009:adverse effects*; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008297:Male; D009329:Nebraska / Q000453:epidemiology; D016017:Odds Ratio; D012516:Osteosarcoma / Q000139:chemically induced* / Q000453:epidemiology