[A structural-functional assessment of serum albumin in cancerous diseases].
HSA structure was studied in healthy subjects and cancer patients using infrared spectroscopy. No significant differences were observed although the intensity of valent C-H fluctuation lines in alkyl groups of HSA was slightly increased in cancer patients. Gas-liquid chromatography established changes in the profile of polyunsaturated fatty acids binding to HSA in cancer patients. The data obtained suggest inhibition of omega-6 pathway of fatty acid metabolism and activation of omega-3 pathway. Marked binding of POL products to serum albumin was found nonspecific and was considered evidence of protective function of that protein.
Tolkacheva
N V
NV
Levachev
M M
MM
Kulakova
S N
SN
Grishkovets
V I
VI
Klishevich
I B
IB
D001650:Bile Duct Neoplasms / Q000097:blood*; D001782:Blood Donors; D002849:Chromatography, Gas; D004591:Electrophoresis, Polyacrylamide Gel; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood*; D010190:Pancreatic Neoplasms / Q000097:blood*; D011487:Protein Conformation; D012709:Serum Albumin / Q000032:analysis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared
D005227:Fatty Acids; D012709:Serum Albumin