title: Late-onset globoid cell leukodystrophy mimicking an infiltrating glioma.
abstract: A 3 1/2 year old girl who developed a gradual left hemiparesis and hemianopia is reported. Neuroimaging studies demonstrated an infiltrating-like high density lesion which crossed the splenium of the corpus callosum, thought to represent a glioma. Subsequent brain biopsy established the correct diagnosis of globoid cell leukodystrophy (GCL), which suggests that the radiographic appearance of late-onset GCL may mimic that of an infiltrating glioma.
authors.affiliation: Department of Neurology, Children's Hospital, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: M A
authors.initials: MA
authors.lastname: Epstein
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
authors.forename: L B
authors.initials: LB
authors.lastname: Rorke
authors.forename: J T
authors.initials: JT
authors.lastname: Sladky
mesh_terms: D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D007965:Leukodystrophy, Globoid Cell / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed