title: CSF interocular interactions in childhood ambylopia.
abstract: Contrast sensitivity functions (CSF's) were measured in the amblyopic and dominant eyes of 17 strabismic and 28 anisometropic children and in 19 similar age normal controls. A three-alternative forced-choice procedure was used to measure CSF's with the VCTS 6500. The results revealed reduced contrast sensitivity (CS) in both the amblyopic and dominant eyes of strabismic and anisometropic amblyopes compared to normal controls. Statistically significant intereye correlations of CS at each spatial frequency were found in all groups and in the presence of deep amblyopia, suggesting continued interocular interactions and binocularity. A separate longitudinal study of 7 of the amblyopes showed that, during the course of occlusion therapy, both the amblyopic and the dominant eyes improved in CSF. The results suggest that the amblyopic eye may influence CS in the dominant eye through interocular interactions. This process may serve to minimize CSF differences between the eyes and maximize binocular vision.
authors.affiliation: Ophthalmology Department, Children's Hospital, Columbus, Ohio.
authors.forename: N
authors.initials: N
authors.lastname: Wali
authors.forename: L E
authors.initials: LE
authors.lastname: Leguire
authors.forename: G L
authors.initials: GL
authors.lastname: Rogers
authors.forename: D L
authors.initials: DL
authors.lastname: Bremer
mesh_terms: D000550:Amblyopia / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D015350:Contrast Sensitivity; D003430:Cross-Sectional Studies; D006801:Humans; D008137:Longitudinal Studies; D014792:Visual Acuity