Examination of factors that may influence disposition of benzo[a]pyrene in vivo: vehicles and asbestos.
Effects of vehicles and of asbestos on disposition of benzo[a]pyrene (B[a]P) were examined in vivo. [3H]B[a]P dissolved in triethylene glycol, ethyl laurate, or tricaprylin was intratracheally administered to male Sprague-Dawley rats. Excretion was most rapid when triethylene glycol was the vehicle, with 70.5% of the recovered dose appearing in bile in 6 h. Lower amounts were excreted into bile when ethyl laurate (58.4%) or tricaprylin (56.2%) were the vehicles, with comparably higher amounts remaining in lungs. When chrysotile asbestos was intratracheally instilled 24 h prior to instillation of [3H]B[a]P dissolved in triethylene glycol, the rate of excretion of radioactivity was slower than without asbestos pretreatment, with only 61.8% of the dose appearing in bile in 6 h.
Bevan
D R
DR
Department of Biochemistry, Virginia Polytechnic Institute, State University, Blacksburg 24061.
Ulman
M R
MR
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D001646:Bile / Q000378:metabolism; D002210:Caprylates / Q000008:administration & dosage; D007848:Laurates / Q000008:administration & dosage; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014132:Trachea; D014280:Triglycerides / Q000008:administration & dosage
D002210:Caprylates; D007848:Laurates; D014280:Triglycerides; D001194:Asbestos; D001564:Benzo(a)pyrene; C028914:triethylene glycol; D011092:Polyethylene Glycols; C003637:tricaprylin; C007677:ethyl laurate