[Concentration of non-steroidal, anti-inflammatory topical agents in the aqueous humor].
In a prospective randomised study we tested two non-steroidal anti-inflammatory medications clinically in a group of 40 eyes. 20 eyes received topically administered indomethacin and another 20 flurbiprofen eyedrops. Before we started the planned extracapsular cataract extraction we performed a puncture of the anterior chamber and aspirated a small volume of anterior chamber fluid. We examined the concentrations of the applied drugs in the aspirated volume. The concentration of indomethacin is 7-9 times higher than that of flurbiprofen.
Strobel
J
J
Universitäts-Augenklinik Giessen.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D003315:Cornea / Q000187:drug effects; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D005480:Flurbiprofen; D007213:Indomethacin