Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.
The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (Cl-8:1 delta 11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 micrograms/ml, respectively.
Hirotani
H
H
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan.
Ohigashi
H
H
Kobayashi
M
M
Koshimizu
K
K
Takahashi
E
E
D000438:Alcohols / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D009829:Oleic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D016354:Rhodobacter capsulatus / Q000032:analysis*; D013604:T-Phages / Q000187:drug effects* / Q000254:growth & development; D014775:Virus Activation / Q000187:drug effects*
D000438:Alcohols; D000998:Antiviral Agents; D005227:Fatty Acids; D009829:Oleic Acids; C065593:cis-vaccenic acid