Otic preparations altered permeability and thickness of the round window membrane of the chinchilla.
The effects of topical otic preparations (Cortisporin, Coly-Mycin, Aristocort, and Bestron) upon the permeability of the round window membrane (RWM) in chinchillas were investigated. Using K(+)-selective microelectrodes, the concentration of tetraethylammonium (TEA) ions was measured. Changes in the thickness of the RWM were measured using light microscopy. The RWM permeability was reduced significantly in Cortisporin- and Coly-Mycin-treated ears. Moreover, these two drugs resulted in a marked thickening of the RWM. In contrast, Aristocort or Bestron resulted in no alteration of the RWM permeability.
Ikeda
K
K
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Morizono
T
T
Takasaka
T
T
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002682:Chinchilla; D003091:Colistin / Q000494:pharmacology; D004338:Drug Combinations; D006854:Hydrocortisone / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D011112:Polymyxin B / Q000494:pharmacology; D012405:Round Window, Ear / Q000187:drug effects*; D014221:Triamcinolone / Q000494:pharmacology
D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D014221:Triamcinolone; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone; D003091:Colistin