title: Genomic changes on the short arm of human chromosome 1 in breast cancer.
abstract: A total of 38 DNA sample pairs from normal and cancerous breasts were specifically examined for alterations on the short arm of chromosome 1 using probe pYNZ2. Of the pairs, 24 (63%) displayed changes at this locus including amplifications, deletions, gene rearrangements, and altered band intensities between heterozygous alleles. Due to technical considerations, this number is likely to be a conservative estimate of the frequency of alterations in this region. When data using a different probe from the short arm of chromosome 1 was added, the overall involvement of this region increased to 73%. The combined data indicate we have localized a region, likely to be less than 85 cm in size, that is involved in the development of breast cancer.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: W M
authors.initials: WM
authors.lastname: Mars
authors.forename: M
authors.initials: M
authors.lastname: Genuardi
authors.forename: H
authors.initials: H
authors.lastname: Tsihira
authors.forename: D E
authors.initials: DE
authors.lastname: Anderson
authors.forename: G F
authors.initials: GF
authors.lastname: Saunders
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization
chemical_list: D004273:DNA, Neoplasm