title: Pathophysiology of renovascular hypertension.
abstract: Renovascular hypertension has its experimental counterpart in the two-kidney, one clip model (Goldblatt hypertension). From the study of this model, a general pathophysiological scheme has evolved suggesting that temporal stages in the development and maintenance of hypertension are regulated by complicated hormonal and neural interrelations. The central roles played by the renin-angiotensin system and the renal nerves is discussed as they relate to other hormones. In addition, the possible contribution of converting enzyme inhibitors to understanding the pathophysiology of this condition is discussed.
authors.affiliation: Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033.
authors.forename: M
authors.initials: M
authors.lastname: Martinez-Maldonado
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D012084:Renin-Angiotensin System; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D012965:Sodium Chloride