[Possibilities for optimizing radiotherapy of cancers of the ENT area by measuring oncoradiogenic enzyme peaks of glucose-6-phosphate isomerase].
Blood samples were taken from 39 patients with head and neck carcinomas after the initial irradiation, and the activity of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) was measured. All patients showed GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5-19.5 h after irradiation, was significantly correlated with tumour size and histological tumour differentiation. A late enzyme peak was associated with regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view, and the value of such enzyme peaks for the optimization of radiation therapy is pointed out.
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Klinik und Poliklinik für Onkologie, Bereich Medizin Charité, Humboldt-Universität zu Berlin.
Tunak
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Dallüge
K H
KH
Henkel
P
P
Nicolai
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T
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000201:enzymology / Q000532:radiotherapy* / Q000601:surgery; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D014062:Tongue Neoplasms / Q000201:enzymology / Q000532:radiotherapy* / Q000601:surgery
D014408:Biomarkers, Tumor; D003037:Cobalt Radioisotopes; D005956:Glucose-6-Phosphate Isomerase