title: [Reproducible determination of the glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) in conscious rats using inulin and p-aminohippuric acid].
abstract: Estimation of the glomerular filtration rate (GFR) and of the effective renal plasma flow (ERPF) by means of the test substances inulin and p-aminohippuric acid according to the steady state clearance measurement during the drop of the plasma level after the initially injection of an depot of the indicators was examined methodologically. The procedure should be repeatable in the same animal under conscious conditions. The results demonstrate that the described method is adequate with regard to accuracy, reproducibility and sensitivity for the estimation of the GFR, whereas limitations apply to calculation of the ERPF.
authors.affiliation: Abteilung Pathophysiologie, Universität Rostock, BRD.
authors.forename: P W
authors.initials: PW
authors.lastname: Wüstenberg
authors.forename: B
authors.initials: B
authors.lastname: Hortian
authors.forename: S
authors.initials: S
authors.lastname: Weirich
authors.forename: A
authors.initials: A
authors.lastname: Kerber
authors.forename: H F
authors.initials: HF
authors.lastname: Kühnle
mesh_terms: D000818:Animals; D005919:Glomerular Filtration Rate; D007444:Inulin; D007668:Kidney / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D012079:Renal Circulation / Q000502:physiology*; D015203:Reproducibility of Results; D010130:p-Aminohippuric Acid
chemical_list: D007444:Inulin; D010130:p-Aminohippuric Acid