Synthesis and cytotoxic activity of a new alkylating derivative of dipyridamole.
Synthesis of 2,6-Bis[bis(2-chloroethyl) amino]-4,8-dipiperidinopyrimido[5,4-d] pyrimidine, a derivative of dipyridamole, was carried out by treating dipyridamole with thionyl chloride. Cytotoxic activity of this compound was assessed using cultured P388 leukaemia cells and HeLa cells. The compound inhibited the colony-forming ability of HeLa cells and showed a cytotoxicity on P388 cells comparable to that of other alkylating drugs (chlorambucil and CCNU).
Andreani
A
A
Dipartimento di Scienze Farmaceutiche dell' Università, Bologna, Italy.
Bossa
R
R
Galatulas
I
I
Ninci
M A
MA
Rambaldi
M
M
D000477:Alkylating Agents / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002699:Chlorambucil / Q000494:pharmacology; D004176:Dipyridamole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007941:Leukemia P388; D008130:Lomustine / Q000494:pharmacology; D051379:Mice; D014410:Tumor Stem Cell Assay
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; C068429:2,6-bis(bis-(2-chloroethyl)amino)-4,8-dipiperidino-pyrimido(5,4-d)pyrimidine; D002699:Chlorambucil; D004176:Dipyridamole; D008130:Lomustine