Male development of chromosomally female mice transgenic for Sry.
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Koopman
P
P
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
Gubbay
J
J
Vivian
N
N
Goodfellow
P
P
Lovell-Badge
R
R
D000818:Animals; D004247:DNA; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D009024:Morphogenesis / Q000235:genetics; D010641:Phenotype; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping; D012732:Sex Determination Analysis; D013045:Species Specificity; D013737:Testis / Q000196:embryology; D014960:X Chromosome; D014998:Y Chromosome
D004247:DNA