Arachidonic acid metabolites in pregnant rat uterus.
Production of prostaglandin E2 (PGE2), F2 alpha (PGF2 alpha) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) by pregnant rat uterus were measured in vitro. At mid-pregnancy, myometrium incubated with decidua attached released more prostanoids into the culture medium than when incubated without. As pregnancy progressed to 21 days more prostanoids were detected in the culture medium. However, no significantly increased conversion of exogenous arachidonic acid (AA) by myometrium was found.
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Monash University Department of Obstetrics and Gynecology, Monash Medical Centre, Clayton, Vic., Australia.
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D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis*; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000378:metabolism*
D001095:Arachidonic Acids; D015237:Dinoprost; D011464:Epoprostenol; D015232:Dinoprostone