[A case of recurrent medulloblastoma treated by combination therapy with cisplatinum and tetrahydropyranyladriamycin (PP therapy)].
PP therapy, combination therapy with Cis-platinum (CDDP) and tetrahydropyranyladriamycin (THP-ADR), were performed on a case of recurrent medulloblastoma. CDDP and THP-ADR involve agents difficult to pass the blood brain barrier (BBB), but can pass BBB on the metastatic lesion. PP therapy is considered to be one of the most effective agents for the treatment of recurrent malignant brain tumor.
Seike
M
M
Department of Neurosurgery, Kochi Medical School, Nankoku, Japan.
Honda
S
S
Moriki
A
A
Nakai
K
K
Sada
Y
Y
Arisawa
M
M
Kurisaka
M
M
Mori
K
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy* / Q000556:secondary / Q000628:therapy
D004317:Doxorubicin; C027260:pirarubicin; D002945:Cisplatin