Decreased vasoactive intestinal polypeptide (VIP) level in cerebrospinal fluid from diabetic patients with neuropathy.
The concentration of vasoactive intestinal polypeptide (VIP) was measured in cerebrospinal fluid (CSF) obtained from diabetic patients with neuropathy and their age-matched control subjects. VIP level in CSF from diabetic patients was significantly decreased as compared with that from the controls (12.9 +/- 3.1 pg/ml vs. 35.4 +/- 3.3 pg/ml, p less than 0.01). Decreased VIP level in CSF may relate with diabetic neuropathy in particular sexual dysfunction.
Umeda
F
F
Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Noda
K
K
Ono
H
H
Chijiiwa
Y
Y
Nawata
H
H
D000328:Adult; D003929:Diabetic Neuropathies / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid*
D014660:Vasoactive Intestinal Peptide