title: [Acute adult respiratory distress syndrome (ARDS) in a patient with amitriptyline poisoning].
abstract: A case of "adult respiratory distress syndrome" after amitriptyline overdosage is reported. Amitriptyline is rapidly absorbed from the intestinal tract and the drug is concentrated in the tissues, particularly the brain, heart and lungs. It is suggested that in large quantities it may inhibit surfactant production and thus cause the clinical picture described. The ventilatory treatments are discussed. It seems that inversed ratio ventilation (IRV) has something to offer, avoiding the use of high oxygen fractions in inspired air and high peak airway pressures. Our patient improved with IRV.
authors.affiliation: Rigshospitalet, Anaestesiafdelingen, København.
authors.forename: I L
authors.initials: IL
authors.lastname: Jarnvig
authors.forename: H O
authors.initials: HO
authors.lastname: Eriksen
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D005260:Female; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D013406:Suicide, Attempted; D014229:Triazolam / Q000506:poisoning*
chemical_list: D000639:Amitriptyline; D014229:Triazolam