title: Acute changes in kidney function following extracorporeal shock wave lithotripsy for renal stones.
abstract: Seventeen patients were subjected to analysis of various renal functional parameters before and after extracorporeal shock wave lithotripsy (ESWL) for renal stones. Thirteen patients were observed at 2 weeks and 3 months. Glomerular filtration rate (GFR) was not influenced by ESWL as based on unchanged serum levels of creatinine, beta 2-microglobulin and creatinine clearance. A significant increase in urinary excretion of beta 2-microglobulin, N-acetyl-beta-glucosaminidase and alkaline phosphatase, with return to pre-treatment values within 4 to 5 days, reflected transient disturbances in proximal tubular function. Urinary albumin excretion was increased 0-24 h after ESWL. No significant alterations were observed in plasma renin activity or serum aldosterone due to ESWL. Serum lactic dehydrogenase remained significantly increased for 2 weeks. In addition, significant changes in several blood and urine parameters were caused by immersion in water and intravenous infusions during treatment and were not specifically due to ESWL.
authors.affiliation: Department of Surgery, Aker Hospital, Oslo, Norway.
authors.forename: S J
authors.initials: SJ
authors.lastname: Karlsen
authors.forename: K J
authors.initials: KJ
authors.lastname: Berg
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000209:etiology; D000469:Alkaline Phosphatase / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007669:Kidney Calculi / Q000503:physiopathology / Q000628:therapy* / Q000652:urine; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase