[Activation of N-myc oncogene and associated genes to chemoresistance, prognostic value for neuroblastoma].
N-myc amplification and ploïdic index are important prognosis factors in neuroblastoma. Combined overexpression of the multidrug resistance gene, MDR1 and of Glutathion-S-Transferase, GST-pi may be related to the response of tumors to chemotherapy. Measurements of these parameters may contribute to define responders and non-responders to chemotherapy and provide the clinician with additional criteria to manage treatment.
Bénard
J
J
Laboratoire de pharmacologie clinique et moléculaire, institut Gustave-Roussy, Villejuif, France.
Bourhis
J
J
Riou
G
G
D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D006801:Humans; D009447:Neuroblastoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D011003:Ploidies; D011379:Prognosis