Differential regulation of estrogen-dependent sexual development of rat brain by growth factors.
Intraventricular infusion of antiserum to nerve growth factor (ANGF), but not that to insulin, epidermal growth factor nor normal rabbit serum, resisted estrogen-induced behavioral defeminization in the female rat neonates. A significant number of the ANGF-treated rats showed lordosis as adults despite neonatal estrogen, but positive feedback of estrogen on serum luteinizing hormone was absent. Sexual phenotype in behavioral and gonadotropic functions may be under differential development regulation.
Hasegawa
N
N
Department of Physiology I, Hirosaki University School of Medicine, Japan.
Takeo
T
T
Sakuma
Y
Y
D000818:Animals; D001921:Brain / Q000254:growth & development*; D004815:Epidermal Growth Factor / Q000276:immunology; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006133:Growth Substances / Q000502:physiology*; D007106:Immune Sera / Q000502:physiology; D007328:Insulin / Q000276:immunology; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors; D011817:Rabbits / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology; D012741:Sexual Maturation
D004967:Estrogens; D006133:Growth Substances; D007106:Immune Sera; D007328:Insulin; D009414:Nerve Growth Factors; D004958:Estradiol; D004815:Epidermal Growth Factor