Vestibular-oculomotor, opto-oculomotor and visual function in the rat after long-term inhalation exposure to toluene.
Pigmented rats were exposed to toluene (1000 ppm, 21 h/day) for 6 or 11 weeks. The function of the vestibulo- and opto-oculomotor systems was tested one month after the end of the exposure by recording of nystagmus, induced by vestibular or optokinetic stimuli. The eye movements were recorded by a magnetic search coil technique. The optokinetic gain in the exposed animals was reduced compared to a control group. There was also a slight reduction in gain during sinusoidal oscillatory vestibular stimulation. No effect of the toluene exposure on the gain or duration of nystagmus during acceleratory or deceleratory rotatory stimulation was demonstrated, nor was there any change in the duration of the optokinetic after-nystagmus. The function of the visual system was tested 2 to 5 days after exposure by recording the electroretinogram and the visual evoked response. The conduction velocity in peripheral nerve was also measured. No effect of the toluene exposure on these variables was seen. The results indicate that long-term inhalation of toluene causes a long-lasting, possibly permanent, lesion within the vestibulo-cerebellum. They gave no evidence that such exposure affects peripheral vestibular or visual function.
Nylén
P
P
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
Larsby
B
B
Johnson
A C
AC
Eriksson
B
B
Höglund
G
G
Tham
R
R
D000280:Administration, Inhalation; D000818:Animals; D004596:Electroretinography / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005133:Eye Movements / Q000187:drug effects; D008297:Male; D009760:Nystagmus, Physiologic / Q000187:drug effects; D009801:Oculomotor Muscles / Q000187:drug effects*; D009802:Oculomotor Nerve / Q000187:drug effects*; D051381:Rats; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects*; D013997:Time Factors; D014050:Toluene / Q000009:adverse effects*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000503:physiopathology
D014050:Toluene