title: Primary structure of a human protein kinase regulator protein.
abstract: A human T-cell cDNA is characterized which codes for a protein closely related to a family of proteins alternatively described as co-regulators, of monoamine biosynthesis in neurons and as inhibitors of protein kinase C. The predicted human protein is 28 kDa and has a pI of 4.5. Alignment of putative protein sequences shows strong conservation from Drosophila to man. Several mRNA transcripts hybridizing to the cDNA are seen in human epithelial and T-cell lines and in various mouse tissues.
authors.affiliation: Max Planck Institut für Immunbiologie, Freiburg, F.R.G.
authors.forename: P J
authors.initials: PJ
authors.lastname: Nielsen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D002352:Carrier Proteins / Q000235:genetics*; D002417:Cattle; D002460:Cell Line; D004247:DNA / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D014158:Transcription, Genetic
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C015482:protein kinase modulator; D004247:DNA; D011494:Protein Kinases