Tetrahydroaminoacridine inhibits high voltage spindle activity in aged rats after acute and chronic treatment.
The present study evaluated the ability of tetrahydroaminoacridine (THA) to reverse the age-related increase in high voltage spindles (HVS). THA was injected either 15 or 90 min before EEG recordings were made. A THA dose of 3 mg/kg IP decreased the incidence of HVS, but was ineffective at doses of 0.03 and 1 mg/kg. The HVS suppressing effect of THA (3 mg/kg) declined during a 10-day treatment period. After 10 days chronic THA treatment, a challenge dose of 6 mg/kg of THA reinstated HVS suppressing effect of THA. Our results suggests that (1) THA reverses the age-related deficit of thalamo-cortical activation (2) tolerance develops to THA-induced HVS suppression (3) anti-cholinesterase activity may be important for the efficacy of THA in decreasing HVS because pilocarpine, a muscarinic agonist, also decreased HVS.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Aaltonen
M
M
Riekkinen
P
P
D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D002802:Cholinesterases / Q000378:metabolism; D004569:Electroencephalography; D004594:Electrophysiology; D005260:Female; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D013619:Tacrine / Q000494:pharmacology*
D010862:Pilocarpine; D013619:Tacrine; D002802:Cholinesterases