[Objective cytological criteria in assessing the degree of the differentiation of breast cancer cells].
Quantitative assessment of basic cytological and some morphometric parameters in punctates obtained from 98 cases of breast cancer showed well-differentiated tumors to have fairly small (126.7 microns 2) nuclei (63.1% of cells), a relatively small number of hyperchromatic and "bare" nuclei (29.6% each) and large nucleoli in the nucleus (9.6%); cell clusters prevailed (coefficient--2.56). Moderately differentiated tumor revealed a wider range of nucleus size, less clustering (coefficient--3.59) and more hyperchromatic (70.1%) and "bare" (49.4%) nuclei and large nucleoli (22.2%). Poorly differentiated carcinomas appeared even more pleomorphic due to increased number of cells (46.5%) containing large (140-260 microns 2) nuclei. The coefficient of clustering was 3.99 whereas the percentage of hyperchromatic and "bare" nuclei and large nucleoli-69.7, 52.1 and 17.4. The above figures may be used to evaluate the degree of tumor cell differentiation in individual patient.
Sil'chenko
S A
SA
Loboda
V I
VI
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003581:Cytodiagnosis; D006801:Humans; D008875:Middle Aged