[IgG subclass antibodies in children of Vallidolid. Low materno-fetal protection].
The anti-tetanus serology was studied in Valladolid during 1988. IgG-antibodies and every one of four IgG-subclasses were determined by ELISA in 144 sera. In this study were included 31 parturient women, 20 newborn, 68 children 1.5-14 years old and 25 younger than 18 months. A 0.01 UI/ml sensibiling and a 8.5% interassay variability coefficient were achieved. The highest mean antibodies level (70.9-39.6 Ua/ml) was presented by children 1.5-3 years old and the lowest (31.1 +/- 15.9 Ua/ml) by 3-5 years old; nevertheless in mothers it was only 1.0 +/- 1.6 Ua/ml. Among children 1.5-14 years old we found only 5/63 (7.9%) cases with non-protective antibodies level. On the contrary, in mothers it increased until 23/31 (74%) and until 16/20 (80%) in cord blood. Antibodies of four IgG subclasses has each other a good correlation, especially IgG1/G2/G4 (p less than 0.001). The IgG2 and IgG3 subclasses were the antibodies which lesser decreased after vaccination. We emphasize the poor anti-tetanus protection of mothers and newborns, lower than levels reported in other countries.
Gutiérrez Diéz
F J
FJ
Cátedra de Pediatría, Facultad de Medicina, Valladolid.
Blanco Quirós
A
A
Ponce Ortega
A
A
Garrote Adrados
J A
JA
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000145:classification / Q000172:deficiency / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D013030:Spain / Q000453:epidemiology; D013742:Tetanus / Q000453:epidemiology / Q000276:immunology*; D013745:Tetanus Toxoid / Q000145:classification / Q000172:deficiency / Q000276:immunology*
D000907:Antibodies, Bacterial; D013745:Tetanus Toxoid