title: Effects of stress and hypophysectomy on distribution of [3H]leucine in the mouse adrenal medulla.
abstract: Effect of stress and hypophysectomy on the distribution of [3H]leucine in the adrenal medulla of mice was examined by autoradiography. [3H]Leucine-derived radioactivity in adrenaline-storing (A) cells of the medulla was remarkably increased by immobilization with water immersion stress. The increase was prevented by adrenal denervation. Adrenal denervation itself reduced [3H]leucine incorporation by A cells. Hypophysectomy also reduced the amount of [3H]leucine in A cells. Although changes in noradrenaline-storing (NA) cells were not statistically significant, they were in the same direction as the changes observed in A cells. Present results showed that neural activity exerts trophic influence on leucine incorporation by adrenal chromaffin cells. Basal pituitary adrenocortical activity seems to be necessary for leucine incorporation in chromaffin cells.
authors.affiliation: Department of Physiology, Niigata University, Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: T
authors.initials: T
authors.lastname: Bando
authors.forename: A
authors.initials: A
authors.lastname: Niijima
mesh_terms: D000311:Adrenal Glands / Q000294:innervation; D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002838:Chromaffin System / Q000166:cytology / Q000378:metabolism; D003714:Denervation; D007016:Hypophysectomy; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D013312:Stress, Physiological / Q000378:metabolism*; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D014316:Tritium; D007930:Leucine