The influence of various drugs on the binding of tianeptine to human plasma proteins.
The plasma binding of the atypical tricyclic antidepressant tianeptine was studied in combination with six drugs, at therapeutic concentrations: cyamemazine, levomepromazine, flunitrazepam, oxazepam, diclofenac and salicylic acid. Of these drugs, only salicylic acid at high plasma concentrations impaired tianeptine binding and thus may potentiate its effects.
Zini
R
R
Département Hospitalo-Universitaire de Pharmacologie, Créteil, France.
Morin
D
D
Salvadori
C
C
Tillement
J P
JP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology; D013841:Thiazepines / Q000097:blood*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D001798:Blood Proteins; D011619:Psychotropic Drugs; D013841:Thiazepines; C050504:tianeptine