[Effects of hyperbaric oxygen therapy on ischemic brain injury in dogs].
The effects of hyperbaric oxygen therapy (OHP) on brain circulation and oxidative stress were studied in dogs following 18 min of complete cerebral ischemia. The intracranial pressure (ICP), cerebral blood flow (CBF), thiobarbituric acid reacting substances (TBARS), non-esterified fatty acids (NEFA) and EEG were measured during and after OHP of 2 atmosphere absolute (ATA) and total duration of 170 min. A significant reduction of ICP was observed 120 min after OHP. CBF showed no significant change. NEFA decreased significantly 150 min after OHP. TBARS showed significant reduction 30, 90, 150 min after OHP. On EEG no spike waves were observed and fast waves (spindle-form) of EEG and the amplitude of slow waves seemed to increase during and after OHP. These results showed that OHP after complete cerebral ischemia was effective in reducing brain damage without increasing oxidative stress.
Yatsuzuka
H
H
Department of Anesthesiology and Resuscitology, Okayama University Medical School.
D000818:Animals; D002545:Brain Ischemia / Q000628:therapy*; D004285:Dogs; D006931:Hyperbaric Oxygenation