Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice.
In mice, an extract of Crocus sativus stigmas partially prevented the decreases in body weight, hemoglobin levels and leucocyte counts caused by 2 mg/kg of cisplatin i.p. for 5 days. Treatment with the C. sativus extract also significantly prolonged the life span of cisplatin-treated mice almost three-fold. In contrast, an extract of Nigella sativa seed only tended to protect from cisplatin-induced falls in hemoglobin levels and leucocyte counts.
Nair
S C
SC
Amala Cancer Research Centre, Kerala, India.
Salomi
M J
MJ
Panikkar
B
B
Panikkar
K R
KR
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D006454:Hemoglobins / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*
D006454:Hemoglobins; D010936:Plant Extracts; D002945:Cisplatin