Cytogenetic analysis of a congenital fibrosarcoma.
Congenital (infantile) fibrosarcoma is a rare soft tissue sarcoma occurring in children aged less than 5 years. We performed cytogenetic analysis on such a tumor, which had an abnormal karyotype: 48,XY, +11, +20. Three other reports of karyotypes in congenital fibrosarcoma describe similar cytogenetic changes, and a specific pattern of trisomies that may prove diagnostic for this tumor is beginning to emerge.
Adam
L R
LR
Division of Human Genetics, University of Newcastle upon Tyne, England.
Davison
E V
EV
Malcolm
A J
AJ
Pearson
A D
AD
Craft
A W
AW
D005354:Fibrosarcoma / Q000151:congenital* / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007866:Leg; D008297:Male; D012983:Soft Tissue Neoplasms / Q000151:congenital* / Q000235:genetics*