Mutagenicity in Salmonella and sister chromatid exchange in mice for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrenes.
The mutagenicity in Salmonella and in vivo sister chromatid exchange in the bone-marrow cells of mice was determined for 1,4-, 1,3-, 2,4-, and 3,4-dimethylphenanthrene (DMPh) with the objective to study the relative importance of substitution at the 1 and 4 positions of this series of methylated phenanthrenes. For both tests, 1,4- DMPh was decidedly more genotoxic than the remaining regioisomers. While the well recognized role of steric crowding in the bay region is a factor in this enhanced genotoxicity, equally important is substitution at the 1 position with its potential to inhibit detoxication through 9,10-diol formation.
Sinsheimer
J E
JE
College of Pharmacy, University of Michigan, Ann Arbor 48109.
Giri
A K
AK
Hooberman
B H
BH
Jung
K Y
KY
Gopalaswamy
R
R
Koreeda
M
M
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D010616:Phenanthrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D009153:Mutagens; D010616:Phenanthrenes