The involvement of insulin in tryptamine-induced hypoglycemia in mice.
The effects of tryptamine on plasma glucose and serum insulin levels were studied in mice. Tryptamine elicited dose-dependent hypoglycemia and hyperinsulinemia in intact mice. In streptozotocin-diabetic mice, tryptamine did not change plasma glucose nor serum insulin levels. Tryptamine significantly inhibited glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. These results indicate that tryptamine-induced hypoglycemia is brought on by its releasing effects of insulin.
Sugimoto
Y
Y
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Kimura
I
I
Yamada
J
J
Watanabe
Y
Y
Takeuchi
N
N
Horisaka
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced; D006946:Hyperinsulinism / Q000097:blood / Q000139:chemically induced*; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D008297:Male; D051379:Mice; D014363:Tryptamines / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D014363:Tryptamines; C030820:tryptamine