[Bone metabolic disorders due to antiepileptic drugs and the therapeutic effect of vitamin D2].
Bone mineral content(BMC), serum calcium, phosphorus and AKP were measured in 64 epileptic patients on long-term treatment with antiepileptics and in 14 epileptic patients not taking antiepileptics. All these indices were also measured in a group of healthy controls. In the epileptic patients taking antiepileptics BMC was significantly lower than that in the control group. Serum calcium and phosphorus were also lower than normal, while AKP was elevated. In the epileptic patients not taking antiepileptics BMC was not significantly different from that in the control group. Serum calcium, phosphorus and AKP were all normal. After 3 months of treatment with vitamin D2, BMC and serum calcium level returned to normal, but AKP was still significantly lowered.
Song
F S
FS
Department of Neurology, First Affiliated Hospital, West China University of Medical Sciences, Chengdu.
Zhou
S S
SS
Yang
D Z
DZ
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000139:chemically induced* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D004872:Ergocalciferols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000927:Anticonvulsants; D004872:Ergocalciferols