title: Monensin controlled-release intraruminal capsule for control of bloat in pastured dairy cows.
abstract: Monensin, a polyether ionophore antibiotic, is potentially an important agent for bloat relief in dairy cows grazing temperate legume-based pasture. A series of studies was undertaken to determine the effect of monensin, when delivered continuously in the rumen of lactating dairy cows by means of controlled-release capsules (monensin CRC). Such devices release approximately 300 mg/head/day for 100 d. A short-term pilot study made at Ruakura, New Zealand, tested monensin CRC in cows selected for high susceptibility to bloat and grazing lucerne (Medicago sativa) or red clover (Trifolium pratense). Treatment significantly reduced the incidence of bloat, while milk yield and protein yield were increased. There was no effect on fat yield. Following the pilot study, 6 large-scale field experiments involving a total of 368 lactating dairy cows, were made in Australia and New Zealand to confirm the effectiveness of monensin CRC for bloat control and to measure the effect of such treatment on milk production and composition. A severe bloat problem occurred in 2 experiments, mild bloat occurred in 2 others, while no visual signs of bloat were observed in the remaining 2 experiments. Bloat was significantly (P less than 0.05) reduced by monensin CRC treatment when data was pooled over the 4 experiments in which bloat occurred. Daily milk yield was increased in all experiments from a mean of 17.7 in untreated groups to 18.8 kg/head/day (P less than 0.05) in monensin CRC-treated cows. Protein percentage was not affected by treatment, while there was a decrease from 4.29 to 4.10% fat, although total fat yield was not affected.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Elanco Products Company, West Ryde, New South Wales.
authors.forename: L B
authors.initials: LB
authors.lastname: Lowe
authors.forename: G J
authors.initials: GJ
authors.lastname: Ball
authors.forename: V R
authors.initials: VR
authors.lastname: Carruthers
authors.forename: R C
authors.initials: RC
authors.lastname: Dobos
authors.forename: G A
authors.initials: GA
authors.lastname: Lynch
authors.forename: P J
authors.initials: PJ
authors.lastname: Moate
authors.forename: P R
authors.initials: PR
authors.lastname: Poole
authors.forename: S C
authors.initials: SC
authors.lastname: Valentine
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004350:Drug Residues / Q000032:analysis; D005260:Female; D007774:Lactation / Q000187:drug effects; D008055:Lipids / Q000032:analysis; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000032:analysis; D008985:Monensin / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D012417:Rumen; D013272:Stomach Diseases / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D003692:Delayed-Action Preparations; D008055:Lipids; D008894:Milk Proteins; D008985:Monensin