Actiketal, a new member of the glutarimide antibiotics.
A new glutarimide antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 microM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-[1H] NOE's techniques.
Sonoda
T
T
RIKEN Institute of Physical and Chemical Research, Saitama, Japan.
Osada
H
H
Uzawa
J
J
Isono
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010881:Piperidones; C068089:actiketal; D013936:Thymidine