title: Simultaneous recording of pattern electroretinogram (PERG) and visual evoked potential (VEP) in multiple sclerosis.
abstract: We studied 18 multiple sclerosis (MS) patients affected by retrobulbar neuritis (RBN). The patients were subdivided into two groups. Group 1: 14 patients with RBN. Group 2: 4 patients with optic atrophy. An ophthalmological examination (visual acuity, fundus oculi, visual field) was carried out in all the patients. A simultaneous visual evoked potential (VEP) and pattern electroretinogram (PERG) recording at two spatial frequencies (45' and 15') was performed. All the data obtained in Group 1 were compared (Student T-Test) with those of a control group of normal subjects matched for age and sex. Group 1. VEP: a comparison of the data in MS patients affected by RBN with the control group revealed a statistically significant P100 latency delay with both spatial frequencies (P less than 0.001). PERG: no "b" wave latency change at 45' and 15' spatial frequencies were seen. A "b" wave amplitude reduction was observed; this reduction reached significant values at 45' (P less than 0.001). Group 2. In optic atrophies the PERG was absent in 4 eyes at 45' and in 5 eyes at 15'.
authors.affiliation: Istituto di Clinica delle Malattie Nervose e Mentali, Università degli Studi La Sapienza, Roma.
authors.forename: E
authors.initials: E
authors.lastname: Stefano
authors.forename: L M
authors.initials: LM
authors.lastname: Cupini
authors.forename: P
authors.initials: P
authors.lastname: Rizzo
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
authors.forename: P A
authors.initials: PA
authors.lastname: Rizzo
mesh_terms: D000328:Adult; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D009896:Optic Atrophy / Q000503:physiopathology; D009902:Optic Neuritis / Q000503:physiopathology; D014792:Visual Acuity; D014794:Visual Fields