title: Second-line chemotherapy of advanced colorectal cancer with sequential high-dose methotrexate and 5-fluorouracil.
abstract: Twenty-five patients with pretreated advanced colorectal carcinoma were subjected to second-line chemotherapy with sequential high-dose methotrexate and 5-fluorouracil. In 20 evaluable patients 2 (10%) partial responses, 12 (60%) stable disease and 6 (30%) progressions were observed. Partial responses were maintained for 3 and 4 months respectively; stable disease had a median duration of 4 months. The overall median survival after progression was 7 months. From our results sequential high-dose methotrexate and 5-fluorouracil cannot be recommended as second-line chemotherapy in advanced colorectal cancer.
authors.affiliation: Cattedra di Oncologia Medica, II Facoltà di Medicina, Università di Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Palmieri
authors.forename: C
authors.initials: C
authors.lastname: Gridelli
authors.forename: G
authors.initials: G
authors.lastname: Airoma
authors.forename: R
authors.initials: R
authors.lastname: Pepe
authors.forename: P
authors.initials: P
authors.lastname: Incoronato
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: A R
authors.initials: AR
authors.lastname: Bianco
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy
chemical_list: D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate