title: Immunogenetics of human American cutaneous leishmaniasis. Study of HLA haplotypes in 24 families from Venezuela.
abstract: Twenty-four families with one or multiple cases of localized cutaneous leishmaniasis (LCL) from an endemic region with the highest incidence of LCL in Venezuela were typed from HLA-ABC, DR, DQ antigens and complement factors. The parental HLA haplotypes segregated at random among healthy and affected siblings but in backcross families significantly higher frequencies of HLA-A28 (p = 0.0018), -Bw22 (p = 0.0122), or -DQw8 (p = 0.0364) were present in affected compared to healthy siblings. HLA-B15 showed a higher frequency (p = 0.0062) among the latter group. Haplotypes Bw22CF31 (p = 0.0076) and Bw22DRw11DQw7 (p = 0.0163) were also significantly more frequent in affected compared to healthy siblings and A2Cw- (p = 0.0445) among the latter. No HLA genetic linkage with a putative LCL susceptibility gene(s) could be demonstrated in this study. A case/control comparison of 26 unrelated LCL patients (one proband from each family) and healthy individuals of the same ethnic origin confirmed the association of HLA-Bw22 (pc = 0.048) and -DQw3 (pc = 0.036) with LCL. The relative risk reached 12.5 for Bw22 and 4.25 for DQw3 with ethiologic factors of 0.17 and 0.64, respectively. HLA-DQw3 apparently makes the major contribution as a genetic risk factor for LCL at the population level.
authors.affiliation: Centro de Medicina Experimental, Instituto Venezolano de Investigaciones, Caracas.
authors.forename: M L
authors.initials: ML
authors.lastname: Lara
authors.forename: Z
authors.initials: Z
authors.lastname: Layrisse
authors.forename: J V
authors.initials: JV
authors.lastname: Scorza
authors.forename: E
authors.initials: E
authors.lastname: Garcia
authors.forename: Z
authors.initials: Z
authors.lastname: Stoikow
authors.forename: J
authors.initials: J
authors.lastname: Granados
authors.forename: W
authors.initials: W
authors.lastname: Bias
mesh_terms: D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007896:Leishmaniasis / Q000235:genetics / Q000276:immunology*; D008297:Male; D014687:Venezuela
chemical_list: D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens