Pentobarbitone inhibits the stress response to transport in male goats.
Pentobarbitone (20 mg/kg i.v.) blocked plasma cortisol release when administered either before a 20 min journey or during a 2 h journey. This confirms that pentobarbitone can block stimulated, as well as resting, cortisol secretion. In general, blood glucose concentrations were not increased above 90 mg/100 ml until at least 30 min after the start of transport; however, this increase was also blocked by pentobarbitone administered 30 min into the 2 h journey. Significant increases in respiratory and heart rates occurred within 15 min of the start of transport; pentobarbitone caused an immediate decrease in these parameters. In conclusion, pentobarbitone was shown to reverse many metabolic changes induced by transport.
Sanhouri
A A
AA
Department of Veterinary Clinical Science, University of Liverpool, Neston, South Wirral.
Jones
R S
RS
Dobson
H
H
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010424:Pentobarbital / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000517:prevention & control / Q000662:veterinary*; D014186:Transportation
D001786:Blood Glucose; D010424:Pentobarbital; D006854:Hydrocortisone