title: Isotretinoin and lung function in systemic sclerosis.
abstract: During an open prospective study of the synthetic retinoid isotretinoin in ten patients with systemic sclerosis, one patient developed an eosinophilic pleural effusion and two patients were noticed to have asymptomatic deterioration in pulmonary function tests. The pulmonary function of all treated patients was then compared retrospectively with a similar control group of patients not treated with isotretinoin. There was a significantly greater decrease in the 1-s forced expiratory volume and transfer coefficient in the patients with systemic sclerosis being treated with isotretinoin in comparison to the untreated control patients. Studies of lung function in patients treated with isotretinoin for other indications are required.
authors.affiliation: Department of Dermatology, University College and Middlesex School of Medicine, Middlesex Hospital, London, UK.
authors.forename: C B
authors.initials: CB
authors.lastname: Bunker
authors.forename: P D
authors.initials: PD
authors.lastname: Maurice
authors.forename: S
authors.initials: S
authors.lastname: Little
authors.forename: N M
authors.initials: NM
authors.lastname: Johnson
authors.forename: P M
authors.initials: PM
authors.lastname: Dowd
mesh_terms: D000328:Adult; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D015474:Isotretinoin