Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole.
Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-difluoro and 4-trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.
Weikert
R J
RJ
Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
Bingham
S
S
Emanuel
M A
MA
Fraser-Smith
E B
EB
Loughhead
D G
DG
Nelson
P H
PH
Poulton
A L
AL
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007978:Levamisole / Q000031:analogs & derivatives; D008297:Male; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy; D012756:Sheep; D013329:Structure-Activity Relationship; D013773:Tetramisole / Q000031:analogs & derivatives
D000871:Anthelmintics; D007978:Levamisole; D013773:Tetramisole