title: Studies on 67Ga uptake by mouse granuloma tissues.
abstract: In connection with the uptake of 67Ga into the inflammatory tissues, such as granuloma tissues produced with turpentine oil, the influence of Fe3+ on the uptake of 67Ga into mouse granuloma and normal tissues and on the uptake of 125I-labeled transferrin and 59Fe were investigated. Fe3+ decreased the uptake of 67Ga into the liver and spleen, but had no influence on the uptake of 67Ga into the granuloma tissues. The uptake patterns of 125I-labeled transferrin and 59Fe in the granuloma tissues were not consistent with that of 67Ga at all. These results show that the uptake of 67Ga into the granuloma tissues occurs in a free, transferrin-unbound form, but into the liver and spleen in a transferrin-bound form.
authors.affiliation: Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohkubo
authors.forename: H
authors.initials: H
authors.lastname: Sawamura
authors.forename: S
authors.initials: S
authors.lastname: Katoh
authors.forename: A
authors.initials: A
authors.lastname: Sasayama
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: A
authors.initials: A
authors.lastname: Kubodera
mesh_terms: D000818:Animals; D005710:Gallium Radioisotopes / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006099:Granuloma / Q000139:chemically induced / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007501:Iron / Q000494:pharmacology; D007504:Iron Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D014168:Transferrin / Q000493:pharmacokinetics; D014425:Turpentine
chemical_list: D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D007504:Iron Radioisotopes; D014168:Transferrin; D007501:Iron; D014425:Turpentine