title: Persistence of supply dependency of oxygen uptake at high levels of delivery in adult respiratory distress syndrome.
abstract: OBJECTIVE
  To identify any plateau in oxygen consumption (VO2) when oxygen delivery (DO2) is increased in patients with the adult respiratory distress syndrome (ARDS).
  
  
  METHODS
  Clinical prospective study; multiple regression analysis was done to assess the relationship between VO2 and DO2 for pooled data and for each individual patient.
  
  
  METHODS
  University hospital ICU.
  
  
  METHODS
  Twenty consecutive patients aged 18 to 78 yrs (mean 43.5) in whom ARDS was present during their ICU stay.
  
  
  METHODS
  Multiple measurements were obtained in individual patients (mean number of measurements 40, range 20 to 83) and mathematical models were fitted to both pooled and individual patient data. DO2 ranged from 212 to 1550 mL/min.m2 with a maximum of 758 to 1550 mL/min.m2 (mean 1136). Because of the large variations between patients, it was not justifiable to describe a relationship for the pooled data and each case was analyzed individually.
  
  
  RESULTS
  We found the optimal regression model to be linear in 13 patients, cubic in four, and either cubic or linear in one. Two patients demonstrated no significant relationship. The relationship for the group was determined from each patient's data and was best described by linear regression.
  
  
  CONCLUSIONS
  In no patient was there evidence of a plateau, despite high levels of DO2 being achieved in all patients.
authors.affiliation: Intensive Care Unit, University Hospital of South Manchester, UK.
authors.forename: C
authors.initials: C
authors.lastname: Clarke
authors.forename: J D
authors.initials: JD
authors.lastname: Edwards
authors.forename: P
authors.initials: P
authors.lastname: Nightingale
authors.forename: A J
authors.initials: AJ
authors.lastname: Mortimer
authors.forename: J
authors.initials: J
authors.lastname: Morris
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D011175:Positive-Pressure Respiration / Q000379:methods; D011446:Prospective Studies; D012044:Regression Analysis; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000378:metabolism* / Q000628:therapy
chemical_list: D010100:Oxygen