Peritonitis complicating continuous ambulatory peritoneal dialysis in Nottingham 1983-1988.
During the period 1983-1988 the incidence of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) in Nottingham fell from 2.0 to 1.2 episodes/patient/year. Cefuroxime, given intraperitoneally for 10 days, as recommended in published guidelines, failed to cure 35% of episodes of peritonitis, although only 7% of the pathogens responsible for these episodes were resistant in vitro. Cefuroxime is probably no longer appropriate as first line treatment of CAPD peritonitis.
Wilcox
M H
MH
Department of Microbial Diseases, City Hospital, Nottingham.
Finch
R G
RG
Burden
R P
RP
Morgan
A G
AG
D001419:Bacteria / Q000187:drug effects; D002444:Cefuroxime / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006801:Humans; D015994:Incidence; D008826:Microbial Sensitivity Tests; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology
D002444:Cefuroxime