Linear gastric emptying of hyperosmolar glucose solutions.
We performed a total of 12 gastric emptying studies on 6 normal subjects with a hyperosmolar (1.85 mol/l) 400-kcal glucose solution commonly used for diagnosing diabetes and a more dilute (0.62 mol/l) 200-kcal glucose solution. The gastric half-emptying time was greatly prolonged with both glucose solutions; 107 min for the (1.85 mol/l) 400-kcal glucose solution compared to 66 min for the more dilute (0.62 mol/l) 200-kcal glucose solution. Although the 200-kcal glucose solution contained one-half the amount of glucose (50 g) compared to the 400-kcal solution (100 g), the blood glucose values obtained during a 2-hr period were only slightly lower with the former solution. This study demonstrates significantly delayed gastric emptying of glucose solutions in normal subjects and a linear pattern of gastric emptying formerly associated only with solid meals.
Phillips
W T
WT
Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800.
Schwartz
J G
JG
Blumhardt
R
R
McMahan
C A
CA
D000284:Administration, Oral; D000328:Adult; D005746:Gastric Emptying / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D009994:Osmolar Concentration; D012016:Reference Values; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D005947:Glucose