HLA antigen-sharing in couples with repeated spontaneous abortions and the birthweight of babies in successful pregnancies.
Previously, several groups reported an increase in HLA antigen-sharing in couples suffering from unexplained repeated spontaneous abortions. It was felt necessary to find out if HLA sharing could have any effect on children born after a successful pregnancy. The birthweight figures of children of 76 couples with repeated spontaneous abortions were analyzed. The results show a significantly lower birthweight in babies born from those couples, presenting a high incidence of HLA antigen-sharing, particularly concerning class II antigens.
Reznikoff-Etievant
M F
MF
Unité d'Immunologie de la Reproducion, Humaine CHP/CNTS, Paris, France.
Bonneau
J C
JC
Alcalay
D
D
Cavelier
B
B
Touré
C
C
Lobet
R
R
Netter
A
A
D000026:Abortion, Habitual / Q000276:immunology*; D001724:Birth Weight; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens