title: MetaModel: a program for modelling and control analysis of metabolic pathways on the IBM PC and compatibles.
abstract: MetaModel is a user-friendly program for calculating steady-state fluxes and metabolite concentrations of metabolic systems on the IBM PC and compatible computers. For any steady state that is obtained, one can then calculate a matrix of elasticity coefficients at that steady state, or a matrix of control and response coefficients. It thus offers a simple way to calculate the control structure of a pathway: it provides not only an educational tool that allows the student to verify empirically the classic summation relationships of metabolic control analysis but also a research tool for addressing 'what if?' questions about the behaviour of metabolic systems. Results can not only be printed or stored in a file, but can also be written to a special file that can be read by popular spreadsheet programs, thereby giving access to rapid, flexible and powerful methods for subsequent analysis and plotting of these results.
authors.affiliation: Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Cornish-Bowden
authors.forename: J H
authors.initials: JH
authors.lastname: Hofmeyr
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D008660:Metabolism / Q000502:physiology*; D008838:Microcomputers; D008954:Models, Biological; D012984:Software; D014584:User-Computer Interface