title: Helicobacter pylori infection in healthy people: a dynamic process?
abstract: Epidemiological studies using serological tests have shown that a large proportion of healthy people have antibodies against Helicobacter pylori (anti-Hp). It is uncertain whether the presence of anti-Hp indicates active infection or only past exposure to the micro-organism. In this study we determined anti-Hp with a specific enzyme linked immunosorbent assay in 100 healthy volunteers who were at the same time investigated for active H pylori infection by means of the 13C-urea breath test. Forty nine per cent had a high anti-Hp titre, but only 24% had active H pylori infection. Our study suggests that a considerable number of healthy people previously infected with H pylori have spontaneously eliminated this microorganism. We suggest that the inability of ulcer patients to eliminate H pylori may be important in the pathogenesis of peptic ulcer disease.
authors.affiliation: Division of Gastroenterology, University Hospital, Basel, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Meyer
authors.forename: B
authors.initials: B
authors.lastname: Werth
authors.forename: C
authors.initials: C
authors.lastname: Beglinger
authors.forename: S
authors.initials: S
authors.lastname: Dill
authors.forename: J
authors.initials: J
authors.lastname: Drewe
authors.forename: W A
authors.initials: WA
authors.lastname: Vischer
authors.forename: R H
authors.initials: RH
authors.lastname: Eggers
authors.forename: F E
authors.initials: FE
authors.lastname: Bauer
authors.forename: G A
authors.initials: GA
authors.lastname: Stalder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis*; D001944:Breath Tests / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology; D015995:Prevalence
chemical_list: D000907:Antibodies, Bacterial