Pregnancy outcome in renal allograft recipients: influence of ciclosporin A.
The outcome of 35 pregnancies in 26 renal allograft recipients is reported. Twenty-four pregnancies in patients treated with prednisolone and azathioprine resulted in 22 live-born infants (one twin pregnancy) and 3 induced abortions on medical indications. Three of the deliveries were preterm, and one of the infants had a birth weight below the 2.5th percentile. Ten patients (11 pregnancies) were treated with ciclosporin A (CsA). These women delivered 5 infants (3 preterm deliveries of whom the birth weight of one infant was below the 5th percentile) and underwent 3 induced (medical indications) and 3 spontaneous abortions. Mean birth weight in the CsA treated group was 2464 g (range 1790-2930 g), and their gestational age varied from 232 to 271 days. No foetal malformations were observed in the two groups. The results may indicate a harmful effect of CsA on pregnancy outcome.
Haugen
G
G
Department of Obstetrics and Gynecology, National Hospital, Oslo, Norway.
Fauchald
P
P
Sødal
G
G
Halvorsen
S
S
Oldereid
N
N
Moe
N
N
D000293:Adolescent; D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood / Q000493:pharmacokinetics; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D016030:Kidney Transplantation; D008657:Metabolic Clearance Rate; D011247:Pregnancy / Q000187:drug effects*; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D003524:Cyclosporins; D003404:Creatinine