title: ECMO without heparin: laboratory and clinical experience.
abstract: To evaluate the feasibility of long-term extracorporeal membrane oxygenation (ECMO) without heparin, we placed six lambs on standard venoarterial ECMO for 71 to 96 hours. Group 1 (3 animals) was given doses of heparin to maintain activated clotting times (ACT) greater than 400 seconds. No form of anticoagulant was used for the three animals in group 2. Blood flow was maintained at 60 mL/kg/min. No histological evidence of thrombosis was noted at necropsy. ACT, prothrombin time, and partial thromboplastin time were higher in group 1, and much lower, although still above normal in group 2. Fibrinogen was significantly lower in group 2 (75 +/- 35 v 219 +/- 64 mg/dL group 1), and, although the platelet count was lower in group 2 (142 +/- 76 x 10(3)/mm3 v 225 +/- 167 x 10(3)/mm3), it was clinically acceptable. These results encouraged us to discontinue heparin when faced with severe hemorrhage in four patients on ECMO, rather than withdraw support at a time when there was little chance of survival. Heparin was discontinued for 10.5 +/- 6 hours. The mean ACT was reduced from 220 +/- 23 seconds to 144 +/- 22 seconds. One patient, who required repair of gastric necrosis while on ECMO following repair of a congenital diaphragmatic hernia, survived and had a decrease in blood loss from 2 to 0 mL/kg/h after the heparin was discontinued. One of the three patients who died had an autopsy with no evidence of thrombosis. We conclude that it may be reasonable to discontinue heparin in the face of life-threatening hemorrhage while on ECMO.
authors.affiliation: Department of Surgery, Wayne State University, Detroit, MI.
authors.forename: G C
authors.initials: GC
authors.lastname: Whittlesey
authors.forename: D E
authors.initials: DE
authors.lastname: Drucker
authors.forename: S O
authors.initials: SO
authors.lastname: Salley
authors.forename: H G
authors.initials: HG
authors.lastname: Smith
authors.forename: S K
authors.initials: SK
authors.lastname: Kundu
authors.forename: S B
authors.initials: SB
authors.lastname: Palder
authors.forename: M D
authors.initials: MD
authors.lastname: Klein
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012756:Sheep
chemical_list: D006493:Heparin