Possible augmentation of antidepressant response by buspirone.
In open trials, seven of eight antidepressant nonresponders reported partial or full antidepressant response after the addition of buspirone 10 mg t.i.d. An additional eight of nine patients who suffered winter relapses of depression while receiving previously effective antidepressant regimens showed remission of depressive symptoms after the addition of buspirone 10 mg t.i.d. Improvement after the addition of buspirone was maintained for at least 3 months, and side effects were minimal in most patients. These results suggest that low doses of buspirone may be useful in augmenting antidepressant response.
Jacobsen
F M
FM
Transcultural Mental Health Institute, Washington, D.C. 20036-6043.
D000328:Adult; D000553:Ambulatory Care; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D000928:Antidepressive Agents; D002065:Buspirone