title: Risk factors and early extracoronary atherosclerotic plaques detected by three-site ultrasound imaging in hypercholesterolemic men. Prévention Cardio-vasculaire en Médecine du Travail METRA Group.
abstract: Ultrasonic detection of atherosclerotic plaque of carotid abdominal aortic and femoral arteries and evaluation of risk factors were performed in 208 hypercholesterolemic men without cardiovascular disease. Twenty-six percent of them had no plaque. Plaque at the carotid, aortic, and femoral sites was found in 37%, 48%, and 53% of subjects, respectively. Plaque was associated (1) in carotid arteries with increased total and low-density lipoprotein cholesterol; (2) in the aorta with increased age, pressure, glycemia, and smoking; and (3) in femoral arteries with increased age, systolic pressure, low-density lipoprotein cholesterol, and smoking. Multiple regression analysis showed correlations between carotid plaque and low-density lipoprotein cholesterol; aortic plaque and age, smoking, glycemia, and pressure; femoral plaque and age, smoking, and pressure. This suggests that multiple risk factors influence lesions, and risk profile differs according to atherosis site.
authors.affiliation: Cardiovascular Preventive Medicine Center, Broussais Hospital, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Giral
authors.forename: I
authors.initials: I
authors.lastname: Pithois-Merli
authors.forename: V
authors.initials: V
authors.lastname: Filitti
authors.forename: J
authors.initials: J
authors.lastname: Levenson
authors.forename: M C
authors.initials: MC
authors.lastname: Plainfosse
authors.forename: C
authors.initials: C
authors.lastname: Mainardi
authors.forename: A C
authors.initials: AC
authors.lastname: Simon
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology / Q000517:prevention & control; D002339:Carotid Arteries; D008078:Cholesterol, LDL / Q000097:blood; D005263:Femoral Artery; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D008078:Cholesterol, LDL