Respiratory patterns during sleep in mitochondrial myopathies with ophthalmoplegia.
Nocturnal polygraphic recordings (electroencephalography, electro-oculography, submental and intercostal muscle electromyography, electrocardiography, respiration by thoracic strain gauges and oronasal thermistors) with continuous monitoring of arterial oxyhemoglobin saturation by pulse oximeter were performed in 8 patients with ophthalmoplegia plus. All patients except 1 had normal blood gas values and normal lung volumes associated with a diminished ventilatory response to inhaled CO2 during wakefulness. Four patients showed pathological sleep-related breathing patterns consisting of sleep apneic polygraphic tracings mainly of the central type or of REM-related hypoventilation episodes. It is suggested that these disorders in patients with ophthalmoplegia plus may have a central origin and be related to the underlying metabolic disturbance.
Manni
R
R
Institute of Neurology, C. Mondino, University of Pavia, Italy.
Piccolo
G
G
Banfi
P
P
Cerveri
I
I
Bruschi
C
C
Zoia
C
C
Tartara
A
A
D000328:Adult; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology*; D009886:Ophthalmoplegia / Q000503:physiopathology*; D015656:Respiratory Mechanics; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*