title: Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease.
abstract: A female patient suffering from a bronchial neuroendocrine tumor with unilateral left-sided carcinoid heart disease is reported. Repeated x-ray films of the chest showed a slowly growing lung tumor in the left lower lobe. The patient refused any diagnostic or therapeutic procedure to define the type of the tumor. During the follow-up of 24 years she developed severe mitral and moderate to severe aortic insufficiency, both invasively quantified by thermodilution techniques. During surgery for double valve replacement the patient died from left ventricular heart failure. Necropsy revealed the typical pattern of a bronchial neuroendocrine tumor without metastases. Examination of the heart disclosed the characteristic deposits of fibrous tissue on the cusps of both the mitral and the aortic valves whereas the right heart showed no abnormalities. Review of the literature suggests the unilateral left-sided carcinoid heart disease to be a very rare finding, its pathogenesis remains to be elucidated.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich, Schweiz.
authors.forename: P
authors.initials: P
authors.lastname: Greminger
authors.forename: O M
authors.initials: OM
authors.lastname: Hess
authors.forename: A E
authors.initials: AE
authors.lastname: Müller
authors.forename: L
authors.initials: L
authors.lastname: von Segesser
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Sütsch
authors.forename: W
authors.initials: W
authors.lastname: Siegenthaler
authors.forename: P U
authors.initials: PU
authors.lastname: Heitz
mesh_terms: D000368:Aged; D001984:Bronchial Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002275:Carcinoid Heart Disease / Q000209:etiology* / Q000473:pathology; D002276:Carcinoid Tumor / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed