Perinatal hematological profile of newborn infants with candida antenatal infections.
We serially studied hematological profiles of 8 newborns with proven antenatal candida chorioamnionitis and funisitis. Candida albicans was cultured from various sources in the infants; blood and CSF cultures were all negative. Seven of the 8 were premature; 5 were sick. We statistically compared hematological data of the 'well' and 'sick' babies. The latter showed neutrophilia (mean 52,381 vs. 11,326/microliters, p less than 0.01) accompanied by significant elevation of nonsegmented granulocytes (NSG) and a NSG/neutrophil ratio greater than 0.3. Significant monocytosis (mean 7,836 vs. 2,869/microliters, p less than 0.01) and eosinophilia (mean 4,723 vs. 782/microliters, p less than 0.05) were also noted. Remarkable toxic granulations, vacuolization, and Döhle bodies were found in the neutrophils of the 'sick' newborns. Hematological profiles correlated with the infants' clinical condition.
Wolach
B
B
Department of Pediatrics, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel.
Bogger-Goren
S
S
Whyte
R
R
D001772:Blood Cell Count; D002177:Candidiasis / Q000097:blood* / Q000175:diagnosis; D002821:Chorioamnionitis / Q000097:blood / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D014470:Umbilical Cord / Q000473:pathology
D006454:Hemoglobins