title: Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments.
abstract: Acute hepatitis is a potential, although rare, complication following administration of high doses of Etoposide (VP 16-213). We report three cases of severe hepatocellular necrosis following administration of standard doses of this antineoplastic agent.
authors.affiliation: Unité d'Hépatologie, Hôpital Laënnec, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Tran
authors.forename: C
authors.initials: C
authors.lastname: Housset
authors.forename: B
authors.initials: B
authors.lastname: Boboc
authors.forename: J M
authors.initials: JM
authors.lastname: Tourani
authors.forename: F
authors.initials: F
authors.lastname: Carnot
authors.forename: P
authors.initials: P
authors.lastname: Berthelot
mesh_terms: D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D005047:Etoposide