Regeneration of autologous and allogenic nerve grafts in a rat genetic model: preliminary report.
The authors report observations concerning rejection and regeneration processes of allogenic peripheral neural tissue, depending on different genetic mismatches in a rat model. Five groups representing different rat strains (n = 100) were subjected to orthotopic grafting of 2.5-cm segments of sciatic nerve. Combinations represented different genetic barriers, including the Major Histocompatibility Complex (MHC), a non-MHC, a subgroup (A) of the MHC, a group representing MHC plus non-MHC, and an autologous control group. Animals were examined after one, two, and 12 weeks; additional evaluations in some of the experimental groups were done at six and eight weeks. Regeneration in varying degrees was evident in all groups at 12 weeks.
Schaller
E
E
Clinic of Plastic and Reconstructive Surgery Medical School of Hannover, Germany.
Lassner
F
F
Becker
M
M
Walter
G F
GF
Berger
A
A
D000818:Animals; D006084:Graft Rejection / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics; D009416:Nerve Regeneration / Q000235:genetics*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000502:physiology / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous / Q000502:physiology; D014184:Transplantation, Homologous / Q000502:physiology