Retinoblastoma. The long-term appearance of radiated intraocular tumors.
A retrospective analysis of 50 patients with retinoblastoma was undertaken to determine the appearance of intraocular retinoblastoma that had received external beam radiation a minimum of 10 years previously. Of the 91 tumors found in 59 eyes, 76 (84%) continued to be ophthalmoscopically visible after 10 years. The most common ophthalmoscopic appearance was a Type III regression pattern. The type of radiation regression pattern correlated with the pretreatment volume of the tumor. The largest tumors (mean, 10.0 disc diameter [dd]) became Type I regression patterns, whereas the smallest tumors (mean, 1.0 dd) completely disappeared. This represents the first long-term follow-up of the intraocular status of radiated retinoblastoma.
Abramson
D H
DH
Ophthalmic Oncology Center, New York Hospital Cornell Medical Center, New York.
McCormick
B
B
Fass
D
D
Ellsworth
R M
RM
Gerardi
C
C
Servodidio
C A
CA
Romanella
A
A
D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012074:Remission Induction; D012175:Retinoblastoma / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies