Symptoms of major depression: acute effect of withdrawing antidepressants.
The literature is devoid of reports indicating that a reduction in the dosage or discontinuation of antidepressants of any chemical class produces symptoms of major depression within 2-4 d. Four cases suggesting that a reduction in the daily dose or withdrawal of an antidepressant may produce symptoms of major depression within hours to days are presented.
Halle
M H
MH
Department of Psychiatry, Ohio State University, Columbus.
Del Medico
V J
VJ
Dilsaver
S C
SC
D000328:Adult; D001143:Arousal / Q000187:drug effects; D002908:Chronic Disease; D003866:Depressive Disorder / Q000139:chemically induced* / Q000188:drug therapy / Q000523:psychology; D003891:Desipramine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000523:psychology*; D014191:Tranylcypromine / Q000008:administration & dosage / Q000009:adverse effects*
D014191:Tranylcypromine; D003891:Desipramine