title: Absorption studies after ileal J-pouch anastomosis for ulcerative colitis. A prospective study.
abstract: Absorption studies were performed in 17 patients with ulcerative colitis operated on with colectomy and an ileal two-limbed J-pouch anastomosis. The patients were studied 3 and greater than or equal to 18 months after closure of the temporary ileostomy. Increased stool mass (median, 609 g/24 h) was found in all patients and was unchanged with time. Moderate steatorrhoea was present in 29% of the patients 3 months postoperatively, but faecal fat excretion normalized with time. Calcium absorption was normal in all but one patient regardless of time after operation. An abnormal bacterial deconjugation, evaluated by a 14C-glycocholic acid breath test was present in 27% of the patients and increased significantly with time. Forty per cent of the patients had increased faecal bile acid excretion. B12 malabsorption was present in 29-35% of the patients. In conclusion, ileal J-pouch anastomosis for ulcerative colitis causes increased stool mass in all patients and produces moderate bile acid deconjugation and malabsorption in about one-third to half. Substitution therapy with vitamin B12 is necessary in about one-third of the patients. Intestinal adaptation as far as absorption is concerned is minimal after the first 3 postoperative months.
authors.affiliation: Dept. of Medicine A, Rigshospitalet, Copenhagen, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Hylander
authors.forename: T
authors.initials: T
authors.lastname: Rannem
authors.forename: J
authors.initials: J
authors.lastname: Hegnhøj
authors.forename: P
authors.initials: P
authors.lastname: Kirkegaard
authors.forename: M
authors.initials: M
authors.lastname: Thale
authors.forename: S
authors.initials: S
authors.lastname: Jarnum
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000601:surgery; D000714:Anastomosis, Surgical / Q000379:methods; D001647:Bile Acids and Salts / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D001647:Bile Acids and Salts; D002118:Calcium