Interleukin-6 positive follicular hyperplasia in the lymph node of a patient with rheumatoid arthritis.
We examined interleukin-6 production in the hyperplastic lymph node of a 77-year-old male rheumatoid arthritis patient with lymphadenopathy. The interleukin-6 production of the lymph node was observed by both immunohistological staining and in vitro culture. The results suggest that interleukin-6 plays a significant pathogenic role in the etiology of the lymphadenopathy seen in many rheumatoid arthritis patients.
Numata
Y
Y
1st Department of Internal Medicine, Kochi Medical School, Japan.
Matsuura
Y
Y
Onishi
S
S
Yamamoto
Y
Y
Ohno
F
F
Tagoh
H
H
Yoshizaki
K
K
Fujimoto
S
S
Yamamoto
H
H
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism* / Q000502:physiology; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008206:Lymphatic Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008297:Male
D015850:Interleukin-6