Pharmacokinetic study of cimetidine in pediatric duodenal ulcer.
The subjects were five schoolboys aged 7 to 12 years with endoscopically proved duodenal ulcers. After the oral administration of 10 mg/kg of cimetidine, the mean peak cimetidine level was 2.86 microgram/ml; the time to peak level was 1.3 hours; the area under the concentration-time curve was 9.74 microgram/ml.hr; the elimination half-life was 1.55 hours; and 56% of the drug was excreted unchanged in the urine. The plasma cimetidine level remained above 1.0 microgram/ml for 3.4 hours and above 0.5 microgram/ml for 5.8 hours. Gastric pH was increased to 5 or above for three to six hours. These results are similar to those reported previously in other pediatric patients. After eight weeks of treatment with 20 mg/kg of cimetidine daily, the duodenal ulcers were completely healed in four of five patients studied.
Kato
S
S
Department of Pediatrics, Sendai City Hospital, Japan.
Watanabe
N
N
Harada
Y
Y
D000284:Administration, Oral; D002648:Child; D002927:Cimetidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004381:Duodenal Ulcer / Q000378:metabolism*; D004384:Duodenoscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D014945:Wound Healing
D002927:Cimetidine