Hypovolemic shock in acute lethal T-2 mycotoxicosis.
Experiments were performed on pentobarbital-anesthetized cats to test the hypothesis that hypovolemia rather than cardiac failure is responsible for the acute lethal toxicity of the trichothecene mycotoxin, T-2 toxin (T2T). Measurements were made on mean arterial blood pressure (MAP), arterial pulse pressure (PP), and heart rate (HR) in eight otherwise untreated cats given T2T (2 mg/kg iv) and in three cats similarly injected with T2T but then transfused with plasma and blood. The transfusions to their available extent significantly delayed or counteracted the development of mycotoxic shock (i.e., depressed MAP and PP) and prevented or reversed a rise in the hematocrit. HR remained stable under all conditions. Plasmapheresis followed by whole-blood removal was found best to simulate mechanistically the mycotoxic shock syndrome in six blood donor cats free of T2T. It is concluded that hypovolemia with polycythemia resulting from plasma leakage and internal bleeding accounts for acute lethal T-2 mycotoxicosis.
Borison
H L
HL
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03756.
Goodheart
M L
ML
Thut
D C
DC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001803:Blood Transfusion; D001809:Blood Viscosity; D001810:Blood Volume; D002415:Cats; D006400:Hematocrit; D006470:Hemorrhage / Q000139:chemically induced; D010956:Plasmapheresis; D012769:Shock / Q000139:chemically induced* / Q000628:therapy; D013605:T-2 Toxin / Q000633:toxicity*
D013605:T-2 Toxin