Alloimmune neonatal neutropenia in monozygous twins. High-dose intravenous gammaglobulin therapy.
An indirect immunofluorescence test using a flow cytometer (FACS420) was useful for detection of antineutrophil antibodies (anti-NA2 antibodies) in a case of monozygous twins with alloimmune neonatal neutropenia. When high-dose intravenous gammaglobulin (300 mg/kg for five consecutive days) was given to one twin, the increase in neutrophils was not obvious. Although neutropenia persisted for about three months, no infections were observed in either of the twins.
Yoshida
N
N
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Shikata
T
T
Sudo
S
S
Matsumura
A
A
Tsujii
H
H
Doi
Y
Y
Kinugasa
A
A
Sawada
T
T
Saito
K
K
Miyamoto
M
M
D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D004200:Diseases in Twins / Q000175:diagnosis / Q000628:therapy*; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis; D007958:Leukocyte Count; D007970:Leukopenia / Q000175:diagnosis; D008297:Male; D009503:Neutropenia / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D009504:Neutrophils / Q000276:immunology; D014430:Twins, Monozygotic
D007136:Immunoglobulins; D007518:Isoantibodies; C035483:venilon