title: Magnetic resonance imaging reflects the chemical changes of aging degeneration in the human intervertebral disk.
abstract: T2 weighed spin echo magnetic resonance images (MRI) of the intervertebral disks of 4 lumbar spines were graded and the nuclei pulposi were analyzed for water, collagen and proteoglycan. The brightness of the nuclear image correlated directly with the proteoglycan concentration, but not with the water or collagen. The dark midnuclear cleft had a collagen concentration slightly higher and a water concentration slightly lower than the adjacent zones; no corresponding differences in proteoglycan were seen, although the relationship with MRI grade was confirmed.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: R H
authors.initials: RH
authors.lastname: Pearce
authors.forename: J P
authors.initials: JP
authors.lastname: Thompson
authors.forename: G M
authors.initials: GM
authors.lastname: Bebault
authors.forename: B
authors.initials: B
authors.lastname: Flak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D001834:Body Water / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D011509:Proteoglycans; D003094:Collagen