Mass spectral characterization of urinary metabolites of D,L-kawain.
The urinary metabolism of D,L-kawain was studied in humans after an oral dose of 200 mg. Ten metabolites of kawain could be identified by gas chromatography-mass spectrometry with electron impact and chemical ionization. The main metabolic pathways were hydroxylation of the phenyl ring, reduction of the 7,8-double bond, hydroxylation of the lactone ring with subsequent dehydration and opening of the lactone ring. The metabolites were mainly excreted in the form of their conjugates.
Köppel
C
C
Reanimationszentrum, Klinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität Berlin, F.R.G.
Tenczer
J
J
D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D009125:Muscle Relaxants, Central / Q000737:chemistry / Q000652:urine*; D011753:Pyrones / Q000737:chemistry / Q000652:urine*
D007202:Indicators and Reagents; D009125:Muscle Relaxants, Central; D011753:Pyrones; C011889:kavain