title: The influence of various drugs on the binding of tianeptine to human plasma proteins.
abstract: The plasma binding of the atypical tricyclic antidepressant tianeptine was studied in combination with six drugs, at therapeutic concentrations: cyamemazine, levomepromazine, flunitrazepam, oxazepam, diclofenac and salicylic acid. Of these drugs, only salicylic acid at high plasma concentrations impaired tianeptine binding and thus may potentiate its effects.
authors.affiliation: Département Hospitalo-Universitaire de Pharmacologie, Créteil, France.
authors.forename: R
authors.initials: R
authors.lastname: Zini
authors.forename: D
authors.initials: D
authors.lastname: Morin
authors.forename: C
authors.initials: C
authors.lastname: Salvadori
authors.forename: J P
authors.initials: JP
authors.lastname: Tillement
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology; D013841:Thiazepines / Q000097:blood*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D001798:Blood Proteins; D011619:Psychotropic Drugs; D013841:Thiazepines; C050504:tianeptine