title: Indium-111-leukocyte imaging in acute cholecystitis.
abstract: Eleven patients with suspected acute cholecystitis underwent sequential 99mTc-iminodiacetic derivative (IDA) and 111In-white blood cell (WBC) imaging to determine if 111In-WBCs accumulate within an acutely inflamed hemorrhagic gallbladder wall and, thus, could be employed as a reasonable alternative to 99mTc-IDA scintigraphy in detecting acute cholecystitis. Seven patients had surgically confirmed acute cholecystitis. Of these cases, five had a true-positive 99mTc-IDA and 111In-WBC, one an indeterminate 111In-WBC and true-positive 99mTc-IDA, and one a true-positive 111In-WBC and false-negative 99mTc-IDA scan. The remaining four patients did not have acute cholecystitis. All visualized their gallbladder within 1 hr after 99mTc-IDA administration and none had 111In-WBC gallbladder wall uptake. Both 111In-WBC and 99mTc-IDA scintigraphy accurately detected acute cholecystitis: hepatobiliary scintigraphy demonstrated a cystic duct obstruction and 111In-WBC imaging detected the inflammatory infiltrate within the gallbladder wall. The sensitivity and specificity of each was 86% and 100%, respectively.
authors.affiliation: Nuclear Medicine Department, William Beaumont Hospital, Royal Oak, Michigan 48073-6769.
authors.forename: D
authors.initials: D
authors.lastname: Fink-Bennett
authors.forename: K
authors.initials: K
authors.lastname: Clarke
authors.forename: D
authors.initials: D
authors.lastname: Tsai
authors.forename: P
authors.initials: P
authors.lastname: Nuechterlein
authors.forename: G
authors.initials: G
authors.lastname: Gora
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002764:Cholecystitis / Q000000981:diagnostic imaging*; D006801:Humans; D007098:Imino Acids; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: D007098:Imino Acids; D007205:Indium Radioisotopes; D015609:Organotechnetium Compounds; C046767:technetium Tc 99m iminodiacetic acid