[New experimental rabbit model with PTFE grafts interpositioned in infrarenal abdominal aorta--influence of hyperlipidemia in prosthetic grafts].
The major obstacle to clinical application of artificial blood vessel grafts with inside diameter of less than 4 mm is neogenic intimal hypertrophy at anastomotic sites. With the aim of preventing this artificial blood vessel graft anatomotic intimal hypertrophy, attempts have been made to improve surgical techniques and develop new materials for sutures and the grafts themselves. In the assessment of the preventive effects of various measures on anastomotic intimal hypertrophy, it is desirable to minimize variation in preoperative arteriosclerotic changes and uniform hemodynamics after vessel replacement surgery among the subjects. The present authors succeeded in creating an infrarenal abdominal aorta replacement model that meets these requirements using rabbits, and conducted experiments using this model to assess the effects of hyperlipidemia on anastomotic intimal hypertrophy. The anastomotic intimal hypertrophy lesion in the present rabbit infrarenal abdominal aorta replacement model is both morphologically and histologically similar to that found in human artificial blood vessel graft anastomotic sites. In addition, this model permits the easy obtain of animals showing the same hemodynamic status after vascular surgery. For these reasons, the present model is expected to serve well as an experimental model of artificial blood vessel graft anastomotic intimal hypertrophy.
Haruta
N
N
Second Department of Surgery, Hiroshima University School of Medicine, Japan.
Fukuda
Y
Y
Dohi
K
K
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000662:veterinary; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000473:pathology; D008297:Male; D011138:Polytetrafluoroethylene; D011817:Rabbits
D011138:Polytetrafluoroethylene