title: [The dynamic content of prostaglandins and cyclic nucleotides in the blood of irradiated dogs and monkeys].
abstract: In experiments with dogs and monkeys a study was made of the dynamics of the content of prostaglandins (PG) and cyclic nucleotides after gamma irradiation. In dogs irradiation with lethal doses (3.1 and 50 Gy) caused a short-term, evidently stress growth of cAMP, PGE and PGF2 alpha levels. At the height of radiation sickness PGF2 alpha and cGMP content decreased considerably. Irradiation of monkeys with a nonlethal dose of 3.2 Gy changed PGE and PGF2 alpha levels to a lesser extent, while concentrations of cyclic nucleotides varied but their ratio remained stable.
authors.forename: V G
authors.initials: VG
authors.lastname: Vladimirov
authors.forename: N G
authors.initials: NG
authors.lastname: Chigareva
authors.forename: L A
authors.initials: LA
authors.lastname: Sharova
mesh_terms: D000818:Animals; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D008253:Macaca mulatta; D008297:Male; D009712:Nucleotides, Cyclic / Q000097:blood / Q000528:radiation effects*; D011453:Prostaglandins / Q000097:blood / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000097:blood; D013997:Time Factors
chemical_list: D009712:Nucleotides, Cyclic; D011453:Prostaglandins