Cellular immunity in preeclampsia: alterations in T-lymphocyte subpopulations during early pregnancy.
T-lymphocyte subpopulations were evaluated longitudinally in 62 primigravidas. Beginning early in the second trimester, women who later developed preeclampsia showed a significantly lower proportion of T-helper cells compared with those who remained normotensive (27.0 +/- 7.1 versus 34.7 +/- 7.9%; P less than or equal to .001). The decrease in the T-helper cell count occurred several weeks before the development of preeclampsia and reverted to normal 6-10 weeks postpartum.
Bardeguez
A D
AD
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark.
McNerney
R
R
Frieri
M
M
Verma
U L
UL
Tejani
N
N
D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008137:Longitudinal Studies; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D016176:T-Lymphocyte Subsets