[Occupational exposure to hazardous substances and risk of cancer in the area of the mouth cavity, oropharynx, hypopharynx and larynx. A case-control study].
A case-control study of squamous cell carcinoma of the upper aerodigestive tract conducted in Heidelberg and Giessen (FRG) provided information on occupational factors in 200 patients and 800 controls (adjusted to sex, age and area of living; 4:1 matched design). The number of subjects exposed to wood dusts, organic chemicals, coal products or to cement was significantly elevated in the tumour group. An increased risk for head and neck cancer was observed after exposition to wood dust (RR = 2,2), organic compounds (RR = 2,4), coal products (RR = 2,7) and especially to cement (RR = 4,4). The cancer risk due to cement exposition showed a positive correlation to the duration of exposition and remained significantly elevated after adjustment for alcohol and tobacco consumption.
Maier
H
H
Univ. HNO-Klinik Heidelberg.
Dietz
A
A
Gewelke
U
U
Heller
W D
WD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D009959:Oropharyngeal Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors
D000395:Air Pollutants, Occupational; D002273:Carcinogens