Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke.
Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.
Hallenbeck
J M
JM
Department of Neurology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD 20814-4799.
Dutka
A J
AJ
Vogel
S N
SN
Heldman
E
E
Doron
D A
DA
Feuerstein
G
G
D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology*; D007276:Injections, Intraventricular; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism* / Q000502:physiology; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D012016:Reference Values; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha