title: Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression.
abstract: Naturally processed minor histocompatibility (H) peptides corresponding to H-4b, H-Y, and an unmapped BALB.B minor H gene were quantified in a relative way in 15 different tissues of male BALB.B mice. For one of these minor H antigens, we could also determine the relative content of the respective protein. For each minor H peptide, an individual tissue distribution was found. Tissues expressing little or no MHC (major histocompatibility complex), like brain, contained only small amounts of minor H peptides or none at all, although the same tissues contained minor H protein in substantial quantities. By contrast, Kb-expressing brains from mice transgenic for Kb under control of the glial acidic protein promoter contained both minor H peptide and protein in high amounts. Thus, the expression of minor H peptides in a given tissue is dependent on coexpression of the restricting MHC class I molecules.
authors.affiliation: Max-Planck-Institut für Biologie Abteilung Immungenetik, Tübingen, Federal Republic of Germany.
authors.forename: P
authors.initials: P
authors.lastname: Griem
authors.forename: H J
authors.initials: HJ
authors.lastname: Wallny
authors.forename: K
authors.initials: K
authors.lastname: Falk
authors.forename: O
authors.initials: O
authors.lastname: Rötzschke
authors.forename: B
authors.initials: B
authors.lastname: Arnold
authors.forename: G
authors.initials: G
authors.lastname: Schönrich
authors.forename: G
authors.initials: G
authors.lastname: Hämmerling
authors.forename: H G
authors.initials: HG
authors.lastname: Rammensee
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology; D002851:Chromatography, High Pressure Liquid; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D015778:Minor Histocompatibility Antigens / Q000032:analysis / Q000235:genetics*; D009928:Organ Specificity; D012867:Skin / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D015778:Minor Histocompatibility Antigens