[Antithrombin III and liver cirrhosis].
Antithrombin III (AT III) levels in 37 healthy people and in 103 patients diagnosed of hepatic cirrhosis (75 due to ethylism, 26 cryptogenic and 7 post-hepatitis) have been studied. Forty seven patients presented a compensation in their cirrhosis and 56 an unbalance. AT III concentration was decreased in cirrhotic patients (14.9 + 1.09 mg/dl), being p less than 0.0005 in relation to healthy patients (24.3 + 0.87 mg/dl). Concentration resulted lesser in patients with unbalance (13.9 + 1.8 mg/dl) than in patients with compensation (18.1 + 1.6 mg/dl). Moreover, statistical study between them showed significant results. AT III, though is a protein whose hepatic synthesis is not clear, decreases in diffuse hepatic disease and so much as more severe is the hepatic damage. Cirrhotic patients did not present thromboembolic phenomena, perhaps because of depression of coagulation factors.
Rodríguez Cuartero
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A
Centro de Investigaciones Médicas Mora Lara, Facultad de Medicina, Universidad de Granada.
Mora Guijosa
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Núñez Carril
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J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis*; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012727:Sex Characteristics
D000990:Antithrombin III