title: A randomized trial of cyclophosphamide, doxorubicin, and prednisone versus cyclophosphamide, 5-fluorouracil, and prednisone in patients with metastatic breast cancer.
abstract: Ninety-four patients were entered in a clinical trial assessing the clinical activity of cyclophosphamide, doxorubicin, and prednisone (CAP) versus a combination of cyclophosphamide. 5-Fluorouracil, and prednisone (CFP) in patients with advanced breast cancer. Objective response rates were comparable, 49% for CFP and 46% for CAP. There was no statistical difference between the duration of response of the two regimens or in time to progression. Most importantly, survival differences were not apparent. Both regimens were clinically tolerable and toxicities, for the most part, were comparable. Thus, no therapeutic advantage existed for either of these polychemotherapy regimens in patients with advanced breast cancer.
authors.affiliation: Division of Medical Oncology Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: D L
authors.initials: DL
authors.lastname: Ahmann
authors.forename: D J
authors.initials: DJ
authors.lastname: Schaid
authors.forename: J N
authors.initials: JN
authors.lastname: Ingle
authors.forename: H F
authors.initials: HF
authors.lastname: Bisel
authors.forename: A J
authors.initials: AJ
authors.lastname: Schutt
authors.forename: J C
authors.initials: JC
authors.lastname: Buckner
authors.forename: H J
authors.initials: HJ
authors.lastname: Long
authors.forename: J
authors.initials: J
authors.lastname: Rubin
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D012983:Soft Tissue Neoplasms / Q000556:secondary*; D015996:Survival Rate
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D011241:Prednisone