title: A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.
abstract: We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.
authors.affiliation: MRC Human Movement and Balance Unit, Institute of Neurology, London, England.
authors.forename: P
authors.initials: P
authors.lastname: Brown
authors.forename: P D
authors.initials: PD
authors.lastname: Thompson
authors.forename: J C
authors.initials: JC
authors.lastname: Rothwell
authors.forename: B L
authors.initials: BL
authors.lastname: Day
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000927:Anticonvulsants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors; D009127:Muscle Rigidity / Q000188:drug therapy*; D009207:Myoclonus / Q000188:drug therapy*; D009460:Neurologic Examination; D013035:Spasm / Q000188:drug therapy; D013577:Syndrome
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; C039332:milacemide