title: Management of congenital diaphragmatic hernia by extracorporeal membrane oxygenation (ECMO).
abstract: The purpose of this study was to evaluate the efficacy of extracorporeal membrane oxygenation (ECMO) for patients with congenital diaphragmatic hernia (CDH). Ten patients whose mortality was predicted to be more than 80% with previous therapeutics, were selected to use ECMO over the past five years. Patients were placed on ECMO by cannulating the right jugular vein and the right carotid artery. ECMO was started at 34.3 hours after birth on an average, and the average time on ECMO was 96.3 hours. Seven patients (70%) survived, and six out of them are in good health without any sequelae. In particular, all five patients whose pathological condition needing ECMO was persistent fetal circulation (PFC), survived. Therefore we believe ECMO is highly beneficial to overcome the condition of PFC. The survival rate of CDH patients under 24 hours of age in our hospital is 76.2% (16/21 cases) over the last 5 years, and it has improved compared with 57.1% (12/21 cases) before then. The fact that some of the critical patients who were lethal with conventional management, have been successfully treated by ECMO, played a great role in this improvement.
authors.affiliation: Department of Pediatric Surgery, Central Hospital, Aichi Prefectural Colony, Kasugai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagaya
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
authors.forename: O
authors.initials: O
authors.lastname: Murahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kishida
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005500:Follow-Up Studies; D006548:Hernia, Diaphragmatic / Q000150:complications* / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*