title: Cocaine use during pregnancy: perinatal outcomes.
abstract: The relation between maternal cocaine use and perinatal outcomes was investigated among 17,466 non-Asian singleton deliveries in 1988 from the University of Illinois Perinatal Network data base in the metropolitan Chicago area. Elevated adjusted relative risks (RR) of low birth weight (RR = 2.8, 95% confidence interval (CI) 2.2-3.7), prematurity (RR = 2.4, 95% CI 1.9-3.1), abruptio placentae (RR = 4.5, 95% CI 2.4-8.5), and perinatal death (RR = 2.1, 95% CI 1.1-4.0) were observed for "any" cocaine users (n = 408) compared with women who did not use cocaine or any other drugs or alcohol (n = 17,058). There was an increased (although unstable) risk of intrapartum placenta previa not previously reported (RR = 2.3, 95% CI 1.0-5.1). The relative risk of small-for-gestational-age births for cocaine users who did not smoke (RR = 3.4, 95% CI 1.8-6.5) was greater than that for cocaine users who did (RR = 2.1, 95% CI 1.1-4.1). Irrespective of smoking status, cocaine use during pregnancy increased the risk of small-for-gestational-age births.
authors.affiliation: School of Public Health, University of Illinois, Chicago 60680.
authors.forename: A
authors.initials: A
authors.lastname: Handler
authors.forename: N
authors.initials: N
authors.lastname: Kistin
authors.forename: F
authors.initials: F
authors.lastname: Davis
authors.forename: C
authors.initials: C
authors.lastname: Ferré
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology; D000328:Adult; D001724:Birth Weight; D002641:Chicago / Q000453:epidemiology; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008423:Maternal Age; D010923:Placenta Previa / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000453:epidemiology; D014029:Tobacco Use Disorder / Q000150:complications
chemical_list: D003042:Cocaine