Improvement of auditory brainstem responses after treatment with zidovudine in a child with AIDS.
A 6 1/2-month-old boy with acquired immunodeficiency syndrome was treated with zidovudine for 12 months. He experienced a marked improvement in clinical and neurologic status. Auditory brainstem responses were recorded before, at 6 months, and after 12 months of therapy; interpeak latency I-V, which was initially delayed, demonstrated progressive shortening that was greater than could be attributed to maturation alone. Auditory brainstem response improvement after zidovudine therapy has not been reported previously.
Brivio
L
L
Pediatric Department IV, University of Milan, Italy.
Tornaghi
R
R
Musetti
L
L
Marchisio
P
P
Principi
N
N
D015526:AIDS Dementia Complex / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000151:congenital / Q000188:drug therapy*; D004569:Electroencephalography / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D015215:Zidovudine / Q000627:therapeutic use*
D015215:Zidovudine