title: The use of fluorocarbon emulsions in cancer radiotherapy.
abstract: The chemical and physical properties of perfluorochemical emulsions which highlight their advantages and disadvantages for use in cancer radiotherapy are summarized. The radiobiological properties of two emulsions are reviewed: we have chosen the Fluosol-DA 20% and the PFOB emulsion 100 v/w% which is one of the most promising second generation fluorocarbon emulsions. The radiosensitization obtained in a human tumor xenograft with PFOB emulsion is compared to that obtained with other modalities used to overcome the radioresistance of tumour cells linked to hypoxia.
authors.affiliation: Laboratoire de Radiobiologie, Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
authors.forename: M
authors.initials: M
authors.lastname: Guichard
mesh_terms: D001802:Blood Substitutes; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004655:Emulsions; D005466:Fluorocarbons / Q000627:therapeutic use*; D006801:Humans; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; D009369:Neoplasms / Q000098:blood supply / Q000532:radiotherapy* / Q000628:therapy; D010952:Plasma Substitutes; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D001802:Blood Substitutes; D004338:Drug Combinations; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D011838:Radiation-Sensitizing Agents; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; C003072:perflubron