Synerazol, a new antifungal antibiotic.
Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.
Ando
O
O
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Satake
H
H
Nakajima
M
M
Sato
A
A
Nakamura
T
T
Kinoshita
T
T
Furuya
K
K
Haneishi
T
T
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003022:Clotrimazole / Q000494:pharmacology; D004357:Drug Synergism; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D011760:Pyrrolidinones; C068886:synerazol; D003022:Clotrimazole