title: Collagen toxicity in rabbits.
abstract: Different preparations of soluble collagen, from rabbit skin, rat skin, rat tail tendon and guinea-pig skin, produced respiratory distress, agitation, convulsions and finally death when infused intravenously in lethal doses. Analysis of plasma enzyme levels indicated significant increases in total, cardiac and hepatic lactate dehydrogenase, suggesting that damage to the liver occurred as a result of collagen infusion. Histopathological examination of lungs, livers and hearts of collagen-treated rabbits confirmed that damage had occurred to the lungs and livers of these animals, while heart tissues appeared to be normal. The source of collagen did not appear to influence its toxicity at the tissue level.
authors.affiliation: Department of Biochemistry, Faculty of Science, Kuwait University, Safat.
authors.forename: S A
authors.initials: SA
authors.lastname: Gomes
authors.forename: M
authors.initials: M
authors.lastname: Thomson
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.forename: M
authors.initials: M
authors.lastname: Alnaqeeb
authors.forename: S H
authors.initials: SH
authors.lastname: Khater
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003094:Collagen / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007275:Injections, Intravenous; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D011817:Rabbits; D051381:Rats
chemical_list: D007527:Isoenzymes; D003094:Collagen; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase