Twenty-four-hour canine lung preservation using UW solution.
The left lungs of 14 mongrel dogs were isolated, preserved, and then reperfused for 120 min. Three groups of lungs were investigated: group 1, nonpreserved lungs (control n = 5); group 2, lungs were flushed with UW solution and cold-stored (4-6 degrees C) in the same flush solution for 24 hr (n = 4); and group 3, lungs flushed and cold-stored with modified Euro-Collins' solution for 24 hr (n = 5). Airway pressure (AWP), static lung compliance (Cst), and pulmonary vascular resistance (PVR) 120 min after reperfusion were significantly higher in group 3 compared with the lungs in group 1 and group 2. AWP was 18.7 +/- 3.9 in group 1, 21.1 +/- 3.8 in group 2, and 33.8 +/- 9.2 ml/cmH2O (mean +/- SD) in group 3 (P less than 0.05). Cst was 14.0 +/- 3.5, 10.8 +/- 1.5, and 6.2 +/- 1.2 ml/cmH2O, respectively (P less than 0.01). Pulmonary vascular resistance was 125 +/- 16, 120 +/- 42, and 410 +/- 108 mmHg/L/min (P less than 0.05). We conclude that UW solution is useful for hypothermic canine lung preservation.
Kawahara
K
K
First Department of Surgery, Nagasaki University School of Medicine, Japan.
Ikari
H
H
Hisano
H
H
Takahashi
T
T
Honshou
S
S
Ayabe
H
H
Tomita
M
M
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D004285:Dogs; D005978:Glutathione; D006982:Hypertonic Solutions; D007328:Insulin; D008168:Lung / Q000473:pathology / Q000502:physiology*; D008170:Lung Compliance; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D019188:Organ Preservation Solutions; D010477:Perfusion; D011652:Pulmonary Circulation; D011887:Raffinose; D015424:Reperfusion; D012996:Solutions; D014655:Vascular Resistance
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose