Percutaneous uptake and kinetics of methyl isobutyl ketone (MIBK) in the guinea-pig.
Continuous intravenous infusion of 0.478 mumol/min methyl isobutyl ketone (MIBK) was performed for 30 min in pentobarbital-anesthetized guinea-pigs. Epicutaneous exposure for 150 min was carried out 2.5 h later after administration of MIBK to a sealed glass ring on the clipped back of the animals. Arterial blood was analyzed for MIBK by gas chromatography. Blood clearance averaged 201 ml.min-1.kg-1 body wt. A maximum percutaneous uptake of 1.1 mumol.min-1.cm-2 was reached 10-45 min after the onset of exposure and decreased to 0.56 mumol.min-1.cm-2 during the latter part of exposure.
Hjelm
E W
EW
Division of Work and Environmental Physiology, National Institute of Occupational Health, Solna, Sweden.
Boman
A
A
Fernström
P
P
Hagberg
M
M
Johanson
G
G
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D008742:Methyl n-Butyl Ketone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012867:Skin / Q000378:metabolism*; D013997:Time Factors
D008742:Methyl n-Butyl Ketone; C005458:methyl isobutyl ketone