Hyperfunctioning metastatic follicular thyroid carcinoma in Pendred's syndrome.
A 66-year-old woman with Pendred's syndrome underwent a partial thyroidectomy when she was 17 years old. At the age of 52 years, she had a second thyroid operation because of hyperthyroidism due to a toxic multinodular goiter with a mediastinal extension consisting of several separate nodules. Five years later a hyperfunctioning metastatic follicular carcinoma was diagnosed histologically. After treatment with radioactive iodine, the patient was well. To the authors' knowledge, this is the first description of a metastatic follicular thyroid carcinoma in Pendred's syndrome and the first report of hyperthyroidism occurring after malignant degeneration of a dyshormonogenetic goiter.
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R
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Department of Endocrinology, University Hospital, Antwerp, Belgium.
Verhelst
J
J
Schoofs
E
E
De Somer
E
E
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000556:secondary; D000368:Aged; D005260:Female; D006042:Goiter / Q000150:complications* / Q000151:congenital; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000097:blood / Q000150:complications* / Q000532:radiotherapy
D007457:Iodine Radioisotopes