Effect of challenge with Candida albicans strains with different levels of virulence on plasma proteins in burned mice.
Immunoglobulin G, immunoglobulin A, transferrin, and fibrinogen were measured by radial immunodiffusion in plasma samples from burned versus unburned mice challenged with high-virulence Candida albicans MY 1044 or its low-virulence mutant, MY 1049. Early decreases in these proteins were found after burn and/or MY 1044 but not MY 1049 challenge. These decreases may contribute to increased susceptibility of mice that were burned and challenged by MY 1044 to lethal candidiasis.
Neely
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Shriners Burns Institute, Cincinnati, Ohio.
Childress
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Holder
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D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D002056:Burns / Q000097:blood*; D002176:Candida albicans / Q000472:pathogenicity*; D005340:Fibrinogen / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D051379:Mice; D014168:Transferrin / Q000032:analysis; D014774:Virulence
D001798:Blood Proteins; D007136:Immunoglobulins; D014168:Transferrin; D005340:Fibrinogen