title: Lower leg subcutaneous blood flow during walking and passive dependency in chronic venous insufficiency.
abstract: The blood flow in the subcutaneous adipose tissue of the lower leg of eight normal subjects and 19 patients with chronic venous insufficiency was measured. The 133Xe-washout technique was used with portable CdT1(C1) detectors and a data storage unit. Only those patients with ulcers and a systolic blood pressure at the toe of greater than or equal to 60 mm were investigated. In the controls the relative blood flow during sitting was 0.61 (range 0.35-0.80). In the patients it was 0.46 (range 0.22-0.87). This difference was not significant. During walking the blood flow increased in controls as well as in the patients compared to the value determined in the sitting position (P = 0.0078 and P = 0.0028, respectively, Wilcoxon matched-pairs test). The relative blood-flow rate during walking was 0.96 (range 0.60-1.58) in the controls, and 1.04 (range 0.49-1.46) in the patients. The difference between the normal subjects and the patients was not significant (P = 0.79). We conclude from our studies that patients with venous insufficiency are able to increase their blood flow during walking to the same extent as normal controls.
authors.affiliation: Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Peters
authors.forename: J H
authors.initials: JH
authors.lastname: Sindrup
authors.forename: L J
authors.initials: LJ
authors.lastname: Petersen
authors.forename: F
authors.initials: F
authors.lastname: Olivarius
authors.forename: L
authors.initials: L
authors.lastname: Danielsen
authors.forename: J K
authors.initials: JK
authors.lastname: Kristensen
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D014689:Venous Insufficiency / Q000503:physiopathology*; D016138:Walking; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes