Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.
Parathyroid hormone-related protein (PTHrP) has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-resorbing factor in tumors with a propensity to metastasize to bone prompted study of PTHrP in breast cancer metastasis. PTHrP was localized by immunohistology in 12 of 13 (92%) breast cancer metastases in bone and in 3 of 18 (17%) metastases in non-bone sites. The statistical difference was highly significant (P less than 0.0001). Production of PTHrP as a bone-resorbing agent may contribute to the ability of breast cancers to grow as bone metastases.
Powell
G J
GJ
University of Melbourne, Department of Surgery, Victoria, Australia.
Southby
J
J
Danks
J A
JA
Stillwell
R G
RG
Hayman
J A
JA
Henderson
M A
MA
Bennett
R C
RC
Martin
T J
TJ
D001859:Bone Neoplasms / Q000737:chemistry* / Q000556:secondary*; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D010281:Parathyroid Hormone / Q000032:analysis*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*; D012189:Retrospective Studies
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins