title: Distribution of endotracheally instilled surfactant protein SP-C in lung-lavaged rabbits.
abstract: In lung-lavaged surfactant-deficient rabbits (n = 6) requiring artificial ventilation, porcine surfactant was instilled endotracheally. This resulted in improvement of lung function so that the animals could be weaned off artificial ventilation. The animals were killed 4 1/2 h after surfactant administration and the porcine surfactant protein was localized in the lung with a MAb. We found surfactant protein in all lobes of the lung but the distribution was not homogeneous. Surfactant protein C was found in less than 15% of the alveolar spaces and in less than 1% of the bronchi.
authors.affiliation: Department of Pediatrics, State University Groningen, The Netherlands.
authors.forename: S B
authors.initials: SB
authors.lastname: Oetomo
authors.forename: L
authors.initials: L
authors.lastname: de Ley
authors.forename: T
authors.initials: T
authors.lastname: Curstedt
authors.forename: J G
authors.initials: JG
authors.lastname: ter Haar
authors.forename: C
authors.initials: C
authors.lastname: Schoots
authors.forename: C R
authors.initials: CR
authors.lastname: Wildevuur
authors.forename: A
authors.initials: A
authors.lastname: Okken
mesh_terms: D000818:Animals; D008168:Lung / Q000378:metabolism*; D011510:Proteolipids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D012121:Respiration, Artificial; D007507:Therapeutic Irrigation; D014018:Tissue Distribution
chemical_list: D011510:Proteolipids; D011663:Pulmonary Surfactants