title: Intraosseous infusion of fluids in the initial management of hypovolemic shock in young subjects.
abstract: Immediate aggressive fluid resuscitation of a child with life-threatening hemorrhagic shock provides the difference between life and death. Obtaining venous access in the hypovolemic child sometimes is difficult and time consuming. In order to evaluate the benefit of prehospital administration of intraosseous fluids into the tibial bone marrow as a method of gaining quick access to the systemic circulation and in resuscitating victims from severe hypovolemic shock, 13 puppies weighing 4.6 to 10 kg were subjected to progressive, controlled exsanguination until their mean arterial pressure (MAP) was 20% or less of their baseline MAP for 5 minutes (maxishock). Then an 18-gauge intraosseous needle was inserted into the tibial bone marrow and lactated Ringer's solution was infused at 300 mm Hg of pressure until a volume three times the blood loss had been administered. The MAP, central venous pressure, arterial blood gases, hematocrit, serum lactate, and urine output were recorded at 10, 20, 30, 45, 60, 90, and 120 minutes after the onset of maxishock. At the end of the experiment the left lung of each animal was sent to the pathology department to investigate the possibility of bone marrow emboli. The results were compared with a group of control dogs with maxishock and no treatment, and a group of dogs with maxishock treated with a canine military antishock trousers inflated to 50 to 55 mm Hg and no fluids. The average needle insertion time was 16 seconds; the rate of infusion of fluids varied from a maximum of 25.7 mL/min to a minimum of 4.5 mL/min, with a mean of 10.6 mL/min.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatric Surgery, Children's Hospital of Philadelphia, PA 19104.
authors.forename: A L
authors.initials: AL
authors.lastname: Velasco
authors.forename: C
authors.initials: C
authors.lastname: Delgado-Paredes
authors.forename: J
authors.initials: J
authors.lastname: Templeton
authors.forename: C K
authors.initials: CK
authors.lastname: Steigman
authors.forename: J M
authors.initials: JM
authors.lastname: Templeton
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001853:Bone Marrow; D004285:Dogs; D005440:Fluid Therapy; D005676:Gravity Suits; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D000077331:Ringer's Solution; D012771:Shock, Hemorrhagic / Q000628:therapy*
chemical_list: D007552:Isotonic Solutions; D000077331:Ringer's Solution