Biological consequences of gene regulation after ionizing radiation exposure.
Ionizing radiation is a ubiquitous environmental mutagen and carcinogen widely used in cancer therapy. However, little is known about the induction of cellular signaling events and specific gene expression after radiation exposure. We review the accumulating evidence that ionizing radiation induces signal transduction pathways involving activation of protein kinase C and a program of genetic events that may contribute to the biological effects of x rays.
Weichselbaum
R R
RR
Department of Radiation and Cellular Oncology, University of Chicago Hospitals and Clinics, Ill.
Hallahan
D E
DE
Sukhatme
V
V
Dritschilo
A
A
Sherman
M L
ML
Kufe
D W
DW
D001483:Base Sequence; D005786:Gene Expression Regulation / Q000528:radiation effects*; D006801:Humans; D008969:Molecular Sequence Data