title: Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra.
abstract: The effect of olestra on vitamin D status was assessed in a 6-wk, double-blind, placebo-controlled study involving 202 free-living adults. Subjects consumed a total of 20 g/d of olestra or triglycerides in cookies eaten at each meal. A 20-micrograms ergocalciferol capsule was taken with each morning meal. Serum 25-hydroxyergocalciferol (25-OHD2) concentrations rose from approximately 5.7 to 39.0 and 31.7 nmol/L in the placebo and olestra groups, respectively, at week 6. At week 6, 25-OHD2 contributed 46-54% to total serum 25-OHD concentration compared with 11% at baseline. The 19% decrease in serum 25-OHD2 concentrations produced by olestra in this study is equivalent to a decrease of approximately 1.2 nmol/L under nonsupplemented dietary conditions. Ingesting 20 g olestra/d in the diet is thus not expected to affect vitamin D nutritional status.
authors.affiliation: Procter & Gamble Company, Cincinnati, OH 45224.
authors.forename: D Y
authors.initials: DY
authors.lastname: Jones
authors.forename: K W
authors.initials: KW
authors.lastname: Miller
authors.forename: B P
authors.initials: BP
authors.lastname: Koonsvitsky
authors.forename: M L
authors.initials: ML
authors.lastname: Ebert
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
authors.forename: M B
authors.initials: MB
authors.lastname: Jones
authors.forename: H F
authors.initials: HF
authors.lastname: DeLuca
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000042:Absorption; D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004311:Double-Blind Method; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014807:Vitamin D / Q000493:pharmacokinetics
chemical_list: D000924:Anticholesteremic Agents; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2; D013395:Sucrose; C013692:sucrose polyester