title: Low haemoglobin in haemophilia children is associated with chronic immune activation.
abstract: Anaemia is a frequent complication in patients with human immunodeficiency virus type 1 (HIV-1) infection. We tested 14 children with severe haemophilia (9 HIV-1 antibody seropositive CDC stage IIA, 5 seronegative) for haemoglobin and urinary neopterin concentrations and found a negative correlation between neopterin and haemoglobin (rs = -0.745, p = 0.007; Spearman's rank correlation). This finding suggests that chronic immune activation, possibly along with the release of specific cytokines such as interferon gamma and tumor necrosis factor alpha may be involved in the pathogenesis of anaemia.
authors.affiliation: Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: E R
authors.initials: ER
authors.lastname: Werner
authors.forename: H
authors.initials: H
authors.lastname: Vinazzer
authors.forename: H
authors.initials: H
authors.lastname: Wachter
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000652:urine; D001708:Biopterins / Q000031:analogs & derivatives / Q000652:urine; D002648:Child; D006679:HIV Seropositivity; D006454:Hemoglobins / Q000378:metabolism*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008297:Male; D019798:Neopterin
chemical_list: D006454:Hemoglobins; D001708:Biopterins; D019798:Neopterin