Genotoxicity of pyrene oxide and 1-nitropyrene oxides in hepatocyte primary culture/DNA repair test.
The genotoxicity of a pyrene oxide, 1-nitropyrene (NP) oxides and other related compounds was examined in the hepatocyte primary culture (HPC)/DNA repair test. Pyrene 4,5-oxide and both 1-NP-4,5-oxide and 1-NP-9,10-oxide elicited clearly positive responses of DNA repair. In this assay, 1-NP itself was weakly positive. However, other related chemicals such as pyrene, 1-nitro-3-hydroxypyrene, 1-nitro-6-hydroxypyrene, and 1-nitro-8-hydroxypyrene did not generate positive responses.
Mori
H
H
Department of Pathology, Gifu University School of Medicine, Japan.
Sugie
S
S
Okumura
A
A
Hara
A
A
Kinouchi
T
T
Kataoka
K
K
Ohnishi
Y
Y
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair; D004269:DNA, Bacterial / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009152:Mutagenicity Tests; D011721:Pyrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D004269:DNA, Bacterial; D011721:Pyrenes; C057067:1-nitropyrene-9,10-oxide; C049292:pyrene 4,5-oxide