title: [Vasculotropin: a new angiogenic growth factor].
abstract: A new growth factor, provisionally named vasculotropin (VAS), with a unique specificity for vascular endothelial cells has been purified to homogeneity. VAS is a 45 kDa glycosylated homodimeric protein. Cloning of the VAS gene has evidenced a sequence homology with A and B chains of Platelet-Derived Growth Factor. The receptor on vascular endothelial cells has been shown to be a 180 kDa protein. A 110 kDa receptor has been found on cells that do not respond to the mitogenic effect of vasculotropin, such as lens epithelial cells or corneal endothelial cells.
authors.affiliation: INSERM U.86, Centre des Cordeliers, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Moukadiri
authors.forename: C
authors.initials: C
authors.lastname: Favard
authors.forename: V
authors.initials: V
authors.lastname: Praloran
authors.forename: J
authors.initials: J
authors.lastname: Plouet
mesh_terms: D006131:Growth Inhibitors / Q000502:physiology; D006133:Growth Substances / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D006131:Growth Inhibitors; D006133:Growth Substances; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors