title: Systemic sclerosis associated with cutaneous exposure to solvent: case report and review of the literature.
abstract: Sclerodermatous skin changes and systemic sclerosis have been reported to occur as a result of contact with several different organic solvents. We describe a 41-year-old man who developed systemic sclerosis after working for 15 years in a foundry, where he had extensive cutaneous contact with multiple organic solvents (trichloroethane, xylene, trimethylbenzene, and naphthalene). Cutaneous exposure to organic solvents may be a factor in the etiology of some cases of systemic sclerosis.
authors.affiliation: Rheumatology Section, Marshfield Clinic, Wisconsin 54449.
authors.forename: R D
authors.initials: RD
authors.lastname: Brasington
authors.forename: A J
authors.initials: AJ
authors.lastname: Thorpe-Swenson
mesh_terms: D000328:Adult; D002196:Capillaries / Q000473:pathology; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D009262:Nails / Q000098:blood supply; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents