title: Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.
abstract: Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
authors.affiliation: Department of Pathology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: R J
authors.initials: RJ
authors.lastname: Rotello
authors.forename: R C
authors.initials: RC
authors.lastname: Lieberman
authors.forename: A F
authors.initials: AF
authors.lastname: Purchio
authors.forename: L E
authors.initials: LE
authors.lastname: Gerschenson
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects; D004847:Epithelial Cells; D005260:Female; D066298:In Vitro Techniques; D009707:Nucleosomes / Q000648:ultrastructure; D011817:Rabbits; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014599:Uterus / Q000166:cytology*
chemical_list: D009707:Nucleosomes; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta