Suppression of ras-transformants (review).
Transforming ras genes are the oncogenes most frequently identified in human cancers. This justifies the intense interest in finding ways to suppress oncogenicity in these gene family-mediated transformants. The methods of suppression can be classified as 1) genetical, 2) biological and 3) pharmacological. Most of the reagents used for the suppression inhibit rodent transformants induced by transfected viral or activated cellular ras oncogenes, but some of the reagents are also effective when applied to natural human transformants that contain activated ras oncogenes. The growth and tumorigenicity of the ras-transformants are suppressed by the inhibition of the integration, transcription, translation or post-translational modification of the ras genes and p21 ras proteins, as well as the inhibition of the expression of genes which collaborate in the ras-transformation or the enhancement of some tumor suppressor genes. These observations offer novel approaches to the investigation of malignant transformation by ras-oncogenes, and have potential application in treatment of ras-oncogene-induced tumors.
Kuzumaki
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Laboratory of Molecular Genetics, Hokkaido University School of Medicine, Sapporo, Japan.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D011905:Genes, ras / Q000187:drug effects; D006801:Humans; D005810:Multigene Family; D013489:Suppression, Genetic; D014162:Transfection
D000970:Antineoplastic Agents