title: Vitamin B-6 deficiency and renal function and structure in chronically uremic rats.
abstract: In preliminary studies, rats with chronic renal failure (CRF) demonstrated worsening renal function, as measured by urea clearance, when fed vitamin B-6-deficient diets. However, urea clearance is not a precise measure of glomerular filtration rate (GFR) and these studies did not indicate the mechanism for the reduced GFR. To measure renal function more precisely and to assess whether B-6 deficiency augments renal injury, we examined [14C]inulin clearance, urine oxalate excretion, and renal histopathology in rats with CRF pair fed to receive a pyridoxine-replete or -deficient diet for 3 or 6 wk. After 3 or 6 wk, pyridoxine-deficient rats had significantly lower [14C]inulin clearances and increased urine oxalate excretion. Histological evaluation indicated increased renal damage in kidneys from pyridoxine-deficient rats as compared with tissue from pyridoxine-replete rats. These findings suggest that in rats with CRF, vitamin B-6 deficiency reduces the GFR and increases renal scarring.
authors.affiliation: Nephrology Section, Portland VA Medical Center, OR 97207.
authors.forename: M
authors.initials: M
authors.lastname: Wolfson
authors.forename: A H
authors.initials: AH
authors.lastname: Cohen
authors.forename: J D
authors.initials: JD
authors.lastname: Kopple
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005919:Glomerular Filtration Rate; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000473:pathology / Q000503:physiopathology*
chemical_list: D010070:Oxalates; D007444:Inulin; D019815:Oxalic Acid; D001219:Aspartate Aminotransferases