Spinal myoclonus: successful treatment with the combination of sodium valproate and L-5-hydroxytryptophan.
We describe a 37-year-old man with spinal segmental myoclonus characterized by symmetric, rhythmic contractions of the abdomen with a frequency ranging between 100 and 150/min. The combination of sodium valproate and L-5-hydroxytryptophan was useful to control the myoclonus. We comment on the possible role of the serotonergic system in this syndrome.
Jiménez-Jiménez
F J
FJ
Unidad de Neurología, Hospital Na Sra, Virgen del Puerto, Plasencia, Cáceres, Spain.
Roldan
A
A
Zancada
F
F
Molina-Arjona
J A
JA
Fernandez-Ballesteros
A
A
Santos
J
J
D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D000328:Adult; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009207:Myoclonus / Q000188:drug therapy*; D013118:Spinal Cord Diseases / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid; D006916:5-Hydroxytryptophan