title: Correction of vesicoureteral reflux by intravesical injection of collagen in a canine model.
abstract: A reflux model was created in 12 dogs to test the application of subureteric injection of collagen as a biodegradable substitute for ureteroneocytostomy. The injection technique was initially successful in 64% of dogs. Failure was related to deficiency in intramural tunnel and was unrelated to bladder function. Cystograms in 4 successfully corrected survivors showed resumption of reflux, although postmortem histology showed persistence of the collagen implant at the injection sites.
authors.affiliation: Department of Surgery, University of Michigan School of Medicine, Ann Arbor.
authors.forename: D E
authors.initials: DE
authors.lastname: Suatengco
authors.forename: D A
authors.initials: DA
authors.lastname: Bloom
authors.forename: K
authors.initials: K
authors.lastname: Oshima
authors.forename: E J
authors.initials: EJ
authors.lastname: McGuire
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D012008:Recurrence; D014563:Urodynamics; D014718:Vesico-Ureteral Reflux / Q000188:drug therapy*
chemical_list: D003094:Collagen