title: Evaluation of acute renal failure with magnetic resonance imaging using gradient-echo and Gd-DTPA.
abstract: Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 micrograms/kg/min) into the renal arteries for 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: H
authors.initials: H
authors.lastname: Munechika
authors.forename: D C
authors.initials: DC
authors.lastname: Sullivan
authors.forename: L W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: C A
authors.initials: CA
authors.lastname: Beam
authors.forename: H D
authors.initials: HD
authors.lastname: Sostman
authors.forename: R J
authors.initials: RJ
authors.lastname: Herfkens
authors.forename: N J
authors.initials: NJ
authors.lastname: Pelc
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000473:pathology; D000818:Animals; D003287:Contrast Media; D004285:Dogs; D019786:Gadolinium DTPA; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D009942:Organometallic Compounds; D004369:Pentetic Acid; D012079:Renal Circulation
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA