T-cell development in the fetus and the invariant series hypothesis.
Comparison of the timing of appearance of certain T-cell markers in the intrathymic development of T cells during gestation reveals a common sequence of expression in several species. Here Richard Aspinall and colleagues put forward a hypothesis concerning this 'invariant series' of markers that shares the same timing of expression across species barriers. It is proposed that T-cell markers that are members of the invariant series are very important in deciding the fate of a developing thymocyte.
Aspinall
R
R
Quadrant Research Foundation, Cambridge, UK.
Kampinga
J
J
van den Bogaerde
J
J
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D005314:Embryonic and Fetal Development / Q000276:immunology; D005333:Fetus / Q000276:immunology*; D005803:Genes, Immunoglobulin / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology* / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface