title: Somatic allelic deletion of nm23 in human cancer.
abstract: Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared to DNA from matched normal tissues. A homozygous deletion of nm23-H1 was observed in a lymph node metastasis of a colorectal carcinoma, indicating that nm23-H1 can be recessively inactivated. The data identify nm23-H1 as a novel, independent locus for allelic deletion in human cancer, a characteristic shared with previously described suppressor genes.
authors.affiliation: Laboratories of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892.
authors.forename: A
authors.initials: A
authors.lastname: Leone
authors.forename: O W
authors.initials: OW
authors.lastname: McBride
authors.forename: A
authors.initials: A
authors.lastname: Weston
authors.forename: M G
authors.initials: MG
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Anglard
authors.forename: C S
authors.initials: CS
authors.lastname: Cropp
authors.forename: J R
authors.initials: JR
authors.lastname: Goepel
authors.forename: R
authors.initials: R
authors.lastname: Lidereau
authors.forename: R
authors.initials: R
authors.lastname: Callahan
authors.forename: W M
authors.initials: WM
authors.lastname: Linehan
mesh_terms: D000483:Alleles; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D008297:Male; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009701:Nucleoside-Diphosphate Kinase; D011506:Proteins / Q000235:genetics*; D014157:Transcription Factors
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins; D011506:Proteins; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins