title: Short nystagmus duration of velocity step response as an indicator of labyrinthine defects.
abstract: The nystagmus response elicited by a velocity step of 90 degrees/s was evaluated in a group of 500 consecutive patients by computer analysis and by measuring the duration (t, in s) of the first phase of the response. A 90% log normal range of 37-55 s (mean 45 s) was established for t directly from the electronystagmogram (ENG) in a group of 12 normal subjects. The computer-based response type 'G-', i.e. 'Gesamtamplitude' (cumulative eye displacement), G less than 480 degrees, yielded a detection rate of labyrinthine defects (LDs) of about 65% with 35% false positives and 15% false negatives. A percentage of only about 25 of LDs was detected, with similar percentages of false detections, when using a criterion based on short t values. The lower yield was partly due to the fact that in some 35% of the cases t could not be measured; in the evaluable cases alone, the detection rate was 60% when using the G criterion and 50% when using the t criterion. It is recommended to measure G directly from the ENG, if t is too short or not available, whenever diminished vestibular responses are suspected.
authors.affiliation: Department of Otolaryngology, Academic Hospital Nijmegen, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Huygen
authors.forename: M G
authors.initials: MG
authors.lastname: Nicolasen
mesh_terms: D000328:Adult; D004584:Electronystagmography / Q000379:methods*; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012027:Reflex, Vestibulo-Ocular