title: Choice of anesthetic agents for peribulbar anesthesia.
abstract: To determine the effectiveness of various combinations of lidocaine, epinephrine, and hyaluronidase with bupivacaine, a prospective, randomized, masked study on 117 patients having cataract extraction under local anesthesia was undertaken. All patients were given a 9 ml peribulbar block by one surgeon, and a graded assessment of analgesia and akinesia was made in a masked fashion one hour later. A mixture using all these agents gave significantly better results than any of the combinations (P = .001). No single agent was shown to be the major determinant of effectiveness. The result suggests a synergistic effect found only when all the agents are combined.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
authors.forename: P H
authors.initials: PH
authors.lastname: House
authors.forename: R H
authors.initials: RH
authors.lastname: Hollands
authors.forename: M
authors.initials: M
authors.lastname: Schulzer
mesh_terms: D000772:Anesthesia, Local; D000779:Anesthetics, Local; D002387:Cataract Extraction; D003228:Conjunctiva / Q000187:drug effects; D004311:Double-Blind Method; D004357:Drug Synergism; D006801:Humans; D010147:Pain Measurement; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local