Patterns of epithelial migration in the unaffected ear in patients with a history of unilateral cholesteatoma.
Epithelial migration in a centrifugal manner is an established phenomenon in the normal human tympanic membrane. This pattern of migration is symmetrical in both ears of any one individual. We present a prospective study on the pattern of tympanic ink dot migration on the normal drum, in patients with a history of cholesteatoma in one ear. It was demonstrated that patients who develop cholesteatoma have a normal migratory pattern and rate in the unaffected ear. The conclusion from this study is that defective migration is not the initiating factor in the development of acquired cholesteatoma.
Moriarty
B G
BG
Department of Otolaryngology, Queen Elizabeth Hospital, Birmingham, UK.
Johnson
A P
AP
Patel
P
P
D002465:Cell Movement; D002781:Cholesteatoma / Q000473:pathology*; D004427:Ear Diseases / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D006801:Humans; D011446:Prospective Studies; D014432:Tympanic Membrane / Q000473:pathology*