Acute psychoses associated with the use of ciprofloxacin and trimethoprim-sulfamethoxazole.
Although adverse drug reactions are a well-recognized cause of mental status changes in the elderly, antimicrobials are rarely implicated. Three patients with serious organic brain disease developed paranoid psychosis after therapy with trimethoprim-sulfamethoxazole or ciprofloxacin was begun. One of the patients was accidently rechallenged and again developed a psychotic reaction. The acute psychoses did not improve with moderate doses of major tranquilizers but resolved completely with drug discontinuation.
McCue
J D
JD
Tufts University School of Medicine, Boston, Massachusetts.
Zandt
J R
JR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D002939:Ciprofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination