title: Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts.
abstract: Feed additive anticoccidials currently used in Japan were examined for possible effects on oocyst sporulation of Eimeria tenella. Monensin, salinomycin, lasalocid, amprolium plus ethpabate, amporolium plus ethopabate plus sulfaquinoxaline, clopidol, or nicarbazin were given to chickens continuously via the feed at the recommended use level or one-half of that level. Oocysts discharged in feces 7-8 days post inoculation (PI) were collected and aerated for sporulation. Low sporulation rate was noted, when clopidol at 62.5 mg kg-1 was given from 4 to 7 days PI. These oocysts were as infective as oocysts from controls, based on weight gain, feed efficiency, gross lesion score of cecae, and oocyst count 7 days PI. The results of the study indicated that the second schizogony and gametogony are vulnerable to clopidol, as evidenced by oocyst sporulation, but infectivity of these sporulated oocysts was not affected.
authors.affiliation: Department of Veterinary Science, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Arakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: E
authors.initials: E
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Fukata
mesh_terms: D000818:Animals; D002645:Chickens / Q000469:parasitology*; D003007:Clopidol / Q000494:pharmacology / Q000627:therapeutic use*; D003048:Coccidiosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use; D004539:Eimeria / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009528:Nicarbazin / Q000494:pharmacology / Q000627:therapeutic use; D011201:Poultry Diseases / Q000469:parasitology / Q000517:prevention & control*; D013170:Spores / Q000187:drug effects
chemical_list: D003049:Coccidiostats; D009528:Nicarbazin; D003007:Clopidol