Butalactin, a new butanolide antibiotic. Taxonomy, fermentation, isolation and biological activity.
Butalactin, [2-(4',5'-epoxy-hex-2'(E)-en)oyl-2-hydroxy-3-hydroxymethyl-2, 3-(Z)-butanolide] is a new antibiotic produced by Streptomyces sp. HIL Y-86,36923. Taxonomically, the producing organism most closely resembles Streptomyces corchorusii. The strain also produces cineromycin B. Though butalactin is structurally related to 'signal molecules' such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain. Butalactin possesses a weak antibiotic activity against Gram-positive and Gram-negative bacteria.
Franco
C M
CM
Microbiology Department, Hoechst India Limited, Bombay.
Borde
U P
UP
Vijayakumar
E K
EK
Chatterjee
S
S
Blumbach
J
J
Ganguli
B N
BN
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003470:Culture Media; D005285:Fermentation; D008854:Microscopy, Electron; D012988:Soil Microbiology; D013171:Spores, Bacterial / Q000648:ultrastructure; D013302:Streptomyces / Q000145:classification / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D013307:Streptomycin / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D003470:Culture Media; C068095:butalactin; D015107:4-Butyrolactone; D013307:Streptomycin