title: Bone marrow perfusion evaluated with gadolinium-enhanced dynamic fast MR imaging in a dog model.
abstract: The authors studied, in a dog model, the feasibility of using gadolinium-enhanced dynamic magnetic resonance (MR) imaging to noninvasively monitor bone marrow perfusion of the proximal femur. With a gradient-recalled acquisition, sequential images of 10 hips in five healthy dogs were obtained for 14 minutes after an intravenous bolus injection of 0.2 mmol of gadopentetate dimeglumine per kilogram. The study was repeated after unilateral arterial embolization of major femoral vessels. Radiolabeled microspheres were injected before and after vessel occlusion. After unilateral embolization, statistically significant differences in enhancement were observed between embolized and control sides (eg, 31% vs 83% average peak enhancement in the femoral neck). There was a high correlation (r = .81 [average]) between the MR data and the microsphere blood flow measurements. The postembolization data indicate that contrast-enhanced fast MR imaging may allow early detection of abnormal bone marrow flow. This technique may be valuable in evaluating patients at risk for avascular necrosis of the femoral head, especially in posttraumatic cases.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: M
authors.initials: M
authors.lastname: Cova
authors.forename: Y S
authors.initials: YS
authors.lastname: Kang
authors.forename: H
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: L C
authors.initials: LC
authors.lastname: Jones
authors.forename: E
authors.initials: E
authors.lastname: McVeigh
authors.forename: B L
authors.initials: BL
authors.lastname: Neff
authors.forename: C J
authors.initials: CJ
authors.lastname: Herold
authors.forename: W W
authors.initials: WW
authors.lastname: Scott
authors.forename: D S
authors.initials: DS
authors.lastname: Hungerford
authors.forename: E A
authors.initials: EA
authors.lastname: Zerhouni
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000098:blood supply; D003287:Contrast Media; D004285:Dogs; D005269:Femur; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods; D008863:Microspheres; D009942:Organometallic Compounds; D004369:Pentetic Acid; D012039:Regional Blood Flow
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA