[Clinical effects of nifedipine on blood pressure and left ventricular performance in patients with isolated hypertension].
17 patients with isolated systolic hypertension (ISH) and 8 with diastolic hypertension (DH) were treated with 10 mg of nifedipine sublingually. In ISH group the blood pressure decreased on the average from 180.2/87.4 to 166.2/84.2, 161.9/82.6, 163.4/83.7 mmHg after 5.20 and 60 minutes, while in DH group the blood pressure decreased on the average from 139.2/102.0 to 138.0/100.0, 137.6/97.6, 134.4/97.2 mmHg. With pulsed Doppler echocardiography, we found that early diastolic time-velocity integral increased (P less than 0.001) and E time prolonged (P less than 0.01) after 20 and 60 minutes in ISH group; and 1/3 filling fraction increased (P less than 0.05) after 20 minutes in DH group. With M-mode echocardiography we found that cardiac index and ejection fraction were improved in both groups. No obvious side effects were noted. From above-mentioned findings we are of the opinion that sublingual nifedipine is effective in reducing blood pressure and improving left ventricular performance especially in ISH patients.
Hua
Q
Q
Xuanwu Hospital, Capital Medical College, Beijing.
Tang
Z
Z
Wang
J R
JR
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects*
D009543:Nifedipine