title: Interleukin-1 beta release from human peripheral blood monocytes associated with phagocytosis of carbonyl-iron or erythrocytes.
abstract: Interleukin-1 beta (IL-1 beta) release from human peripheral blood monocytes during the incubation with carbonyl-iron or sheep red blood cells was investigated. The incubation of purified monocytes with carbonyl-iron or sheep red blood cells enhanced IL-1 beta release, while their compounds, hemoglobin, globin and ferric citrate did not. The mechanisms of IL-1 beta release by carbonyl-iron or sheep red blood cells may be related to their phagocytosis, as non-phagocytic monocytes did not release IL-1 beta.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Sasano
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: S
authors.initials: S
authors.lastname: Aotsuka
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Yokohari
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D054354:Iron Carbonyl Compounds; D009000:Monocytes / Q000276:immunology*; D009942:Organometallic Compounds / Q000276:immunology; D010587:Phagocytosis
chemical_list: D007375:Interleukin-1; D009942:Organometallic Compounds; D054354:Iron Carbonyl Compounds