title: Cerebrospinal fluid tumour markers in patients treated for meningeal malignancy.
abstract: The results of cerebrospinal fluid (CSF) biochemical markers were compared with conventional CSF cytology in patients treated for leptomeningeal metastases from extra cranial malignancies. For lumbar CSF, before treatment, no statistically significant difference of the probabilities of being positive was found between CSF cytology and a classification by linear discriminant analysis, based on patient's age, of beta-glucuronidase and beta 2-microglobulin. During treatment, classification by linear discriminant analysis was found more often positive than cytology. Possible mechanisms for this difference are discussed. For ventricular CSF a correlation was found between CSF cytology and beta-glucuronidase for solid tumours, and between CSF cytology and beta 2-microglobulin for haematological malignancies. Reference values for ventricular protein, CEA beta-glucuronidase and beta 2-microglobulin were obtained for cytological negative samples.
authors.affiliation: Municipal Hospital, Department of Clinical Chemistry, Amsterdam, The Netherlands.
authors.forename: A P
authors.initials: AP
authors.lastname: van Zanten
authors.forename: A
authors.initials: A
authors.lastname: Twijnstra
authors.forename: B W
authors.initials: BW
authors.lastname: Ongerboer de Visser
authors.forename: P
authors.initials: P
authors.lastname: van Heerde
authors.forename: A A
authors.initials: AA
authors.lastname: Hart
authors.forename: W J
authors.initials: WJ
authors.lastname: Nooyen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D001786:Blood Glucose / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D005966:Glucuronidase / Q000134:cerebrospinal fluid; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D012016:Reference Values; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid
chemical_list: D014408:Biomarkers, Tumor; D001786:Blood Glucose; D002272:Carcinoembryonic Antigen; D002556:Cerebrospinal Fluid Proteins; D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase; D008727:Methotrexate