Human immunodeficiency virus associated with thrombotic thrombocytopenic purpura: successful treatment with zidovudine.
Thrombocytopenia associated with human immunodeficiency virus (HIV) is well described, and two recent reports show a beneficial effect with the antiretroviral agent zidovudine (ZDV). HIV-associated thrombotic thrombocytopenic purpura (TTP) has recently been observed, but the use of ZDV for it has not been previously described. We have reported a case of relapsing TTP in an HIV-positive man who achieved remission with plasmapheresis and antiplatelet therapy initially, but multiple relapses necessitated the addition of vincristine and ZDV to induce a sustained remission.
Salem
G
G
Department of Medicine, Henry Ford Hospital, Detroit, Mich.
Terebelo
H
H
Raman
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000188:drug therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use*
D015215:Zidovudine