Posterior cricoarytenoid activity in normal adults during involuntary and voluntary hyperventilation.
The effect of isocapnic hypoxia and hyperoxic hypercapnia on the electrical activity of the posterior cricoarytenoid (PCA) muscle was determined in eight normal adult humans by use of standard rebreathing techniques and was compared with PCA activity during voluntary hyperventilation performed under isocapnic and hypocapnic conditions. PCA activity was recorded with intramuscular hooked-wire electrodes implanted through a fiberoptic nasopharyngoscope. During quiet breathing in all subjects, the PCA was phasically active on inspiration and tonically active throughout the respiratory cycle. At comparable increments in respiratory output, hypercapnia, hypoxia, and voluntary hyperventilation appeared to be associated with similar increases in phasic or tonic PCA activity. During quiet breathing, the onset of phasic PCA activity usually occurred before inspiratory airflow and extended beyond the start of expiratory airflow. The duration of phasic PCA preactivation and postinspiratory phasic PCA activity remained unchanged during progressive hypercapnia and progressive hypoxia. The results, in combination with recent findings for vocal cord adductors, suggest that vocal cord position throughout the respiratory cycle during hyperpnea is actively controlled by simultaneously acting and antagonistic intrinsic laryngeal muscles.
Kuna
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Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
Day
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Insalaco
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Villeponteaux
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D000328:Adult; D004576:Electromyography; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D006985:Hyperventilation / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology; D007821:Laryngeal Muscles / Q000503:physiopathology*; D008297:Male; D014827:Vocal Cords / Q000502:physiology