title: Treatment of alopecia areata with diphenylcyclopropenone.
abstract: One hundred thirty-nine patients with severe alopecia areata (the majority with the subtotal, total, or universalis type) were treated with topical immunotherapy (diphenylcyclopropenone). Patients were initially treated unilaterally; the other side of the scalp served as a control. In 50.4% of the patients the response was either excellent (total regrowth) or satisfactory (subtotal regrowth with only a few remaining bald patches). The most frequent side effects were eczematous reactions with blistering, spreading of the induced contact eczema, and sleep disturbances.
authors.affiliation: Department of Dermatology, University of Nijmegen, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: van der Steen
authors.forename: H M
authors.initials: HM
authors.lastname: van Baar
authors.forename: C M
authors.initials: CM
authors.lastname: Perret
authors.forename: R
authors.initials: R
authors.lastname: Happle
mesh_terms: D000287:Administration, Topical; D000506:Alopecia Areata / Q000628:therapy*; D003521:Cyclopropanes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000209:etiology; D004485:Eczema / Q000139:chemically induced; D006801:Humans; D007167:Immunotherapy; D012008:Recurrence
chemical_list: D003521:Cyclopropanes; C029402:diphenylcyclopropenone