[The effect of irradiation and alkylating agents on chromatin breakdown in normal and malignant lymphoid cells].
Regularities of chromatin degradation in thymocytes and LS/BL tumor cells have been investigated. It has been shown that the rate of DNA degradation by Ca/Mg-dependent endonuclease in LS/BL tumor cells is 25 times lower than that in thymocytes, and radiation does not induce chromatin degradation. The alkylating agent TS 160 causes chromatin degradation in both LS/BL cells and thymocytes. In contrast to radiation TS 160 inhibits the endogenous chromatin degradation by Ca/Mg-dependent endonuclease in thymocytes.
Riabchenko
N I
NI
Jurasková
V
V
Ivannik
B P
BP
Konov
A V
AV
Drasil
V
V
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002843:Chromatin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005720:Gamma Rays; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects*; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
D000477:Alkylating Agents; D002843:Chromatin; D004273:DNA, Neoplasm; D009588:Nitrogen Mustard Compounds; C009802:2,2',2''-trichlorotriethylamine; D004247:DNA