title: Combination chemotherapy in advanced adenocarcinoma of the fallopian tube.
abstract: Advanced adenocarcinoma of the fallopian tube has a poor prognosis, with 5-year survival rates commonly less than 20%. Since 1980, we have managed 12 patients with disseminated tumor with combination chemotherapy following surgical cytoreduction. Analogous to the International Federation of Gynecology and Obstetrics staging of ovarian carcinoma, 3 patients were classified in Stage II, 8 in Stage III, and 1 in Stage IV. Ten patients received cisplatin-containing regimens. The 3 Stage II patients, without measurable disease after primary surgery, had an indeterminate response to chemotherapy. In Stages III-IV there were 4 complete responses (3 confirmed by second-look laparotomy) and 2 partial responses, for an overall response rate of 67%. Disease progressed in 2 patients and was stable in 1 patient. After median follow-up of 3.5 years, 4 of the Stage III-IV patients have no evidence of disease, 1 is alive with disease, and 4 are dead.
authors.affiliation: Department of Gynecology, Massachusetts General Hospital, Boston 02114.
authors.forename: H G
authors.initials: HG
authors.lastname: Muntz
authors.forename: H M
authors.initials: HM
authors.lastname: Tarraza
authors.forename: B A
authors.initials: BA
authors.lastname: Goff
authors.forename: G O
authors.initials: GO
authors.lastname: Granai
authors.forename: L W
authors.initials: LW
authors.lastname: Rice
authors.forename: N
authors.initials: N
authors.lastname: Nikrui
authors.forename: A F
authors.initials: AF
authors.lastname: Fuller
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D005185:Fallopian Tube Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D002945:Cisplatin