Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin.
20-(S)-Camptothecin (CAM), a plant alkaloid, was tested against 13 human cancer xenograft lines carried by immunodeficient (nude) mice. The drug, formulated in 20% intralipid and given i.m., was more effective than any other clinically available drug tested. It was found that: (a) CAM, at nontoxic doses, suppressed growth and induced regression of cancer of the colon (3 lines), lung (4 lines), breast (2 lines), stomach (1 line), ovary (1 line), and malignant melanoma (2 lines); (b) the drug was equally effective administered i.m. or p.o. Both routes are significantly better than i.v. administration; (c) CAM is substantially more effective and less toxic than its sodium salt, which was unsuccessfully tested in cancer patients. CAM should be further tested against responsive cancers as a drug which is easy to isolate and formulate for large-scale studies.
Giovanella
B C
BC
St. Joseph Hospital Cancer Research Laboratory, Houston, Texas 77003.
Hinz
H R
HR
Kozielski
A J
AJ
Stehlin
J S
JS
Silber
R
R
Potmesil
M
M
D000818:Animals; D002166:Camptothecin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D002166:Camptothecin