title: Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.
abstract: Parathyroid hormone-related protein (PTHrP) has recently been identified in 60% of a series of primary breast cancers. The detection of a bone-resorbing factor in tumors with a propensity to metastasize to bone prompted study of PTHrP in breast cancer metastasis. PTHrP was localized by immunohistology in 12 of 13 (92%) breast cancer metastases in bone and in 3 of 18 (17%) metastases in non-bone sites. The statistical difference was highly significant (P less than 0.0001). Production of PTHrP as a bone-resorbing agent may contribute to the ability of breast cancers to grow as bone metastases.
authors.affiliation: University of Melbourne, Department of Surgery, Victoria, Australia.
authors.forename: G J
authors.initials: GJ
authors.lastname: Powell
authors.forename: J
authors.initials: J
authors.lastname: Southby
authors.forename: J A
authors.initials: JA
authors.lastname: Danks
authors.forename: R G
authors.initials: RG
authors.lastname: Stillwell
authors.forename: J A
authors.initials: JA
authors.lastname: Hayman
authors.forename: M A
authors.initials: MA
authors.lastname: Henderson
authors.forename: R C
authors.initials: RC
authors.lastname: Bennett
authors.forename: T J
authors.initials: TJ
authors.lastname: Martin
mesh_terms: D001859:Bone Neoplasms / Q000737:chemistry* / Q000556:secondary*; D001943:Breast Neoplasms; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D010281:Parathyroid Hormone / Q000032:analysis*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*; D012189:Retrospective Studies
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins