[Acute hemorrhagic cystitis following chlordimeform poisoning ].
A 19-year-old and a 50-year-old man who together had cleaned a water-tank as part of their duties in a tank protection and cleaning firm developed that same evening lower abdominal pain, dysuria and haematuria. Cystoscopy revealed haemorrhagic cystitis in both patients, a finding confirmed by bladder mucosa biopsy. 4-chlor-2 methylaniline (concentration less than 1 mg/l) was found in hydrolysed serum of both. This metabolite of the pesticide chlordimeform was also found in the urine of the 51-year-old patient (16 mg/l). The haematuria regressed within two days of the patients having increased their fluid intake. Dysuria improved within a week. It is likely that chlordimeform had previously been transported in the water-tank. In case of haemorrhagic cystitis possibly caused by occupational or other poisoning, serum and urine should always be obtained for toxicological tests.
Jurincic
C
C
Urologische Klinik, Allgemeines Krankenhaus, Celle.
Horlbeck
R
R
Metz
K
K
Klippel
K F
KF
D000208:Acute Disease; D000328:Adult; D000814:Aniline Compounds / Q000032:analysis; D001706:Biopsy; D002742:Chlorphenamidine / Q000493:pharmacokinetics / Q000506:poisoning*; D003556:Cystitis / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D001743:Urinary Bladder / Q000473:pathology
D000814:Aniline Compounds; C011716:4-chloro-N-methylaniline; D002742:Chlorphenamidine