Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. Could oxidative stress be involved in the brain?
Adams
J D
JD
School of Pharmacy, University of Southern California, Los Angeles 90033.
Odunze
I N
IN
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D020267:MPTP Poisoning; D008636:Mesencephalon / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000503:physiopathology; D014810:Vitamin E / Q000502:physiology
D005609:Free Radicals; D008054:Lipid Peroxides; D014810:Vitamin E; D006861:Hydrogen Peroxide; D005978:Glutathione; D004298:Dopamine