Inhibition of growth and pulmonary metastasis of B16-F10 murine melanoma by N-1554, a polyprenyl phosphate.
Antitumor effect of N-1554 (alpha-dihydrodecaprenyl phosphate containing eight trans internal isoprene residues) against B16-F10 melanoma in syngeneic C57BL/6 mice was examined. B16-F10 cells were inoculated into the footpad of mice and N-1554 was intraperitoneally administered after the inoculation. The drug significantly inhibited the tumor growth in the footpad and dramatically reduced the pulmonary metastasis from the tumor. The antitumor effect of N-1554 was almost abolished when the immunosuppressant carrageenan or anti-asialo GM1 antibody was administered to mice. In addition, pretreatment of host mice with N-1554 reduced the growth of subcutaneously inoculated B16-F10 melanoma. These results suggest that enhancement of host immune system may be involved in the antitumor effect of N-1554.
Okamoto
Y
Y
Research Center, Nisshin Flour Milling Co. Ltd., Saitama, Japan.
Ohwaki
T
T
Kawase
S
S
Ishii
Y
Y
Hongyo
T
T
Tahara
Y
Y
Mishima
Y
Y
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D000970:Antineoplastic Agents; D002351:Carrageenan / Q000494:pharmacology; D002460:Cell Line; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000276:immunology; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011106:Polyisoprenyl Phosphates / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000627:therapeutic use*
D000906:Antibodies; D000970:Antineoplastic Agents; D006028:Glycosphingolipids; D011106:Polyisoprenyl Phosphates; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D002351:Carrageenan; C048155:dihydrodecaprenyl phosphate