Apomorphine is a potent inhibitor of type 2A protein phosphatase in rat brain.
Effects of five kinds of dopamine agonists on the activity of type 2A protein phosphatase in rat brain were studied. Apomorphine and SKF-38393 reduced the enzyme activity considerably and their effects were further enhanced in the presence of 10 microM Mn2+. Also, 6,7-ADTN slightly inhibited the activity. The present results suggest that type 2A protein phosphatase in the brain is possibly involved in dopamine mediated protein phosphorylation functions.
Kawai
S
S
Laboratory of Biology, Osaka Dental University, Japan.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors*; D010766:Phosphorylation; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000097847:Protein Phosphatase Inhibitory Proteins
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001058:Apomorphine; D010750:Phosphoproteins; D011506:Proteins; C024833:protein phosphatase inhibitor-2; D000097847:Protein Phosphatase Inhibitory Proteins