Helvecardins A and B, novel glycopeptide antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical properties.
A strain of actinomycetes identified as Pseudonocardia compacta subsp. helvetica produced new glycopeptide antibiotics, helvecardins A and B. They were isolated from culture broth mainly by affinity chromatography of D-alanyl-D-alanine and preparative HPLC. The physico-chemical properties of helvecardins A and B showed that they resemble each other. Though helvecardin A was structurally related to beta-avoparcin, it clearly differed in the presence of an O-methyl moiety in its NMR spectrum.
Takeuchi
M
M
Fermentation Research Laboratories, Sankyo Co, Ltd., Tokyo, Japan.
Enokita
R
R
Okazaki
T
T
Kagasaki
T
T
Inukai
M
M
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D009618:Nocardiaceae / Q000145:classification* / Q000378:metabolism / Q000648:ultrastructure; D013055:Spectrophotometry, Infrared
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C068812:helvecardin A; C068813:helvecardin B