5-Methoxytryptamine is metabolized by monoamine oxidase A in the pineal gland and plasma of golden hamsters.
Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin were also measured following 5-methoxytryptamine administration to hamsters pretreated with MAO inhibitors. A significant increase in pineal and plasma 5-methoxytryptamine together with a decrease in 5-methoxytryptophol concentrations was observed after clorgyline or pargyline. In contrast, following deprenyl administration, no change in pineal and plasma 5-methoxyindoles was observed. These results indicate that monoamine oxidase A is responsible for oxidative deamination of 5-methoxytryptamine.
Raynaud
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F
CNRS URA 1332, Neurobiologie des fonctions rythmiques et saisonnières, Université Louis Pasteur, Strasbourg, France.
Pévet
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P
D008735:5-Methoxytryptamine / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D008647:Mesocricetus / Q000097:blood / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010870:Pineal Gland / Q000378:metabolism*
D008996:Monoamine Oxidase Inhibitors; D008735:5-Methoxytryptamine; D008995:Monoamine Oxidase