A comparative PET study using different 11C-labelled amino acids in Walker 256 carcinosarcoma-bearing rats.
In Walker 256 carcinosarcoma-bearing rats, the dynamic distribution of L-[1-11C]tyrosine, L-[methyl-11C]methionine, L-[1-11C]methionine and D-[1-11C]methionine has been measured by PET. An equivalent tumor-imaging potential was observed for each of the three L-amino acids. Thirty minutes after injection, the tumors accumulated 57% (P less than 0.01) more 11C-activity from L-[1-11C]methionine than from L-[methyl-11C]methionine. At the same point of time, the livers showed a 33% (P less than 0.001) higher 11C-uptake with L-[methyl-11C]methionine than with L-[1-11C]methionine. The dynamic tissue data are in agreement with the findings in experiments with 14C-analogs.
Daemen
B J
BJ
Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands.
Elsinga
P H
PH
Ishiwata
K
K
Paans
A M
AM
Vaalburg
W
W
D000596:Amino Acids / Q000493:pharmacokinetics; D000818:Animals; D002250:Carbon Radioisotopes; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging* / Q000378:metabolism; D008715:Methionine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014443:Tyrosine / Q000493:pharmacokinetics
D000596:Amino Acids; D002250:Carbon Radioisotopes; D014443:Tyrosine; D008715:Methionine; C038344:methionine methyl ester