The absorption of chlortetracycline following transscrotal instillation for the treatment of primary hydrocele testis.
We describe the absorption of chlortetracycline from the emptied hydrocele sac, which was instilled to treat a primary hydrocele of the testis. The study included 7 patients and 2 control subjects who were given 500 mg. chlortetracycline. Plasma concentration was determined at 0, 1/2, 1, 2, 4, 6, 12 and 24 hours after instillation, and in 2 patients plasma levels also were determined at 48 and 72 hours. The area under the plasma concentration-time curve (AUC1) was calculated in each case by using the trapezoidal rule. In the control group the plasma level was determined at 0, 1, 2, 4 and 6 hours after instillation. The area under the plasma concentration-time curve (AUC2) was calculated by the formula AUC2 = Co/Kc. The fraction F of absorption can be expressed as F = AUC1/AUC2; median F = 0.67 (range 0.41 to 0.92). We conclude that chlortetracycline passes readily and almost completely through the tunica vaginalis lining the hydrocele sac.
Bødker
A
A
Department of Surgery, Holbaek Hospital, Copenhagen, Denmark.
Rasmussen
T B
TB
Christensen
M B
MB
D000042:Absorption; D000368:Aged; D000369:Aged, 80 and over; D002751:Chlortetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D015911:Sclerotherapy; D012611:Scrotum; D006848:Testicular Hydrocele / Q000378:metabolism / Q000628:therapy*
D002751:Chlortetracycline