title: Psychological profiles of patients with upper gastrointestinal symptomatology induced by non-steroidal anti-inflammatory drugs.
abstract: Eighty three patients with classical or definite rheumatoid arthritis taking non-steroidal anti-inflammatory drugs (NSAIDs) were studied in an attempt to determine whether a patient's personality and psychological profile might contribute to the development of NSAID induced gastrointestinal symptomatology. It was found that the personality profile of the group of 45 asymptomatic patients was similar to that of a previously reported control group. In contrast, the 37 patients with gastrointestinal symptoms attributed to NSAIDs had a significantly higher mean score for free floating anxiety, depression, and somatisation than controls, suggesting that a patient's personality may influence the development of NSAID induced gastric symptoms.
authors.affiliation: Department of Rheumatology, University of Alberta, Edmonton, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Juby
authors.forename: P
authors.initials: P
authors.lastname: Davis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001007:Anxiety / Q000523:psychology; D001172:Arthritis, Rheumatoid / Q000523:psychology*; D003863:Depression / Q000150:complications; D004415:Dyspepsia / Q000139:chemically induced / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000209:etiology; D010551:Personality; D010556:Personality Tests; D012189:Retrospective Studies; D013001:Somatoform Disorders / Q000150:complications
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal