title: Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron emitting radionuclides.
abstract: Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.
authors.affiliation: Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: R
authors.initials: R
authors.lastname: Finn
authors.forename: N K
authors.initials: NK
authors.lastname: Cheung
authors.forename: C
authors.initials: C
authors.lastname: Divgi
authors.forename: J
authors.initials: J
authors.lastname: St Germain
authors.forename: M
authors.initials: M
authors.lastname: Graham
authors.forename: K
authors.initials: K
authors.lastname: Pentlow
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
mesh_terms: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes