In vitro activities of acridone alkaloids against Pneumocystis carinii.
Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 microM, respectively. This potency of effect is similar to that of chloroquine (3 microM) but somewhat less than that of primaquine (0.4 microM), which was previously evaluated in the same system.
Queener
S F
SF
Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis 46202-5120.
Fujioka
H
H
Nishiyama
Y
Y
Furukawa
H
H
Bartlett
M S
MS
Smith
J W
JW
D000166:Acridines / Q000494:pharmacology*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D011010:Pneumocystis / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000166:Acridines; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic