title: Topical metronidazole in the treatment of perioral dermatitis.
abstract: The twice-daily topical application of 1% metroindazole cream was compared with 250 mg oral tetracycline, taken twice daily, in the treatment of perioral dermatitis in a prospective, double-blind, double-dummy, randomized, multicenter trial. One hundred eight patients were treated for 8 weeks. At the end of this time the median number of papules in the metronidazole-treated group was reduced to 8% of the initial number, and the median number in the group treated with tetracycline was reduced to 0% of the initial number. Although both treatments were effective, oral tetracycline was significantly more effective than topical metronidazole.
authors.affiliation: Dermatology Clinic, Aalborg, Denmark.
authors.forename: N K
authors.initials: NK
authors.lastname: Veien
authors.forename: J M
authors.initials: JM
authors.lastname: Munkvad
authors.forename: A O
authors.initials: AO
authors.lastname: Nielsen
authors.forename: A M
authors.initials: AM
authors.lastname: Niordson
authors.forename: D
authors.initials: D
authors.lastname: Stahl
authors.forename: J
authors.initials: J
authors.lastname: Thormann
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003872:Dermatitis / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004890:Erythema / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*; D011446:Prospective Studies; D013754:Tetracyclines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D013754:Tetracyclines; D008795:Metronidazole