title: Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces.
abstract: Addition of an aqueous extract of Hibiscus sabdariffa calyces (2.5 ml/bath approximately 125 mg of starting crude material) inhibited the tone of various isolated muscle preparations (rabbit aortic strip, rhythmically contracting rat uterus, guinea-pig tracheal chain and rat diaphragm). Other muscles were stimulated (quiescent rat uterus and frog rectus abdominis). Intravenous injection of the extract to anaesthetized cats lowered the blood pressure in a dose-response manner. The inhibitory effects were resistant to a number of standard receptor blockers but the hypotensive influence was partially blocked by atropine and the tonic effects on rat uterus were partially reduced by hydrocortisone and indomethacin.
authors.affiliation: Medicinal and Aromatic Herbs Research Institute, National Council for Research, Khartoum, Sudan.
authors.forename: M B
authors.initials: MB
authors.lastname: Ali
authors.forename: W M
authors.initials: WM
authors.lastname: Salih
authors.forename: A H
authors.initials: AH
authors.lastname: Mohamed
authors.forename: A M
authors.initials: AM
authors.lastname: Homeida
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010276:Parasympatholytics; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats
chemical_list: D010276:Parasympatholytics; D010936:Plant Extracts