title: Otic preparations altered permeability and thickness of the round window membrane of the chinchilla.
abstract: The effects of topical otic preparations (Cortisporin, Coly-Mycin, Aristocort, and Bestron) upon the permeability of the round window membrane (RWM) in chinchillas were investigated. Using K(+)-selective microelectrodes, the concentration of tetraethylammonium (TEA) ions was measured. Changes in the thickness of the RWM were measured using light microscopy. The RWM permeability was reduced significantly in Cortisporin- and Coly-Mycin-treated ears. Moreover, these two drugs resulted in a marked thickening of the RWM. In contrast, Aristocort or Bestron resulted in no alteration of the RWM permeability.
authors.affiliation: Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Morizono
authors.forename: T
authors.initials: T
authors.lastname: Takasaka
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002682:Chinchilla; D003091:Colistin / Q000494:pharmacology; D004338:Drug Combinations; D006854:Hydrocortisone / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D011112:Polymyxin B / Q000494:pharmacology; D012405:Round Window, Ear / Q000187:drug effects*; D014221:Triamcinolone / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D014221:Triamcinolone; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone; D003091:Colistin