Is there a link between fluoridated water and osteosarcoma?
To test the hypothesis that fluoride is a risk factor for osteosarcoma, a case control study compared the complete residential fluoride histories of osteosarcoma patients with matched hospital-based controls. Fluoridation was not found to be a risk factor for osteosarcoma in the study population. The trend in the data from this small sample study suggests the hypothesis that a protective effect may exist against the formation of osteosarcoma for individuals consuming fluoridated water.
McGuire
S M
SM
Harvard School of Dental Medicine, Boston.
Vanable
E D
ED
McGuire
M H
MH
Buckwalter
J A
JA
Douglass
C W
CW
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D005457:Fluoridation / Q000009:adverse effects*; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008297:Male; D009329:Nebraska / Q000453:epidemiology; D016017:Odds Ratio; D012516:Osteosarcoma / Q000139:chemically induced* / Q000453:epidemiology