title: Early bone changes in experimental osteoarthritis using microscopic computed tomography.
abstract: Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in cartilage. To evaluate the influence of the myectomy on the animals, a gait study was performed. This data reveals an alteration in acceleration at the foot-flat phase of gait in the operated limb only, providing early quantification of the interaction between mechanics and biology.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor.
authors.forename: D K
authors.initials: DK
authors.lastname: Dedrick
authors.forename: R
authors.initials: R
authors.lastname: Goulet
authors.forename: L
authors.initials: L
authors.lastname: Huston
authors.forename: S A
authors.initials: SA
authors.lastname: Goldstein
authors.forename: G G
authors.initials: GG
authors.lastname: Bole
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology; D002356:Cartilage / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D004195:Disease Models, Animal; D005684:Gait / Q000502:physiology; D006168:Guinea Pigs; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed