title: Precooling prevents overheating of subcutaneous fat in the use of RF capacitive heating.
abstract: The usefulness of precooling subcutaneous tissue in the hyperthermic treatment of deep-seated human tumors with capacitive application of radio-frequency (RF) was investigated. A capacitive hyperthermia unit operated at 8 MHz of radiofrequency was used to heat deep-seated human tumors. The electrode surfaces were covered with flexible vinyl sheets and the space between the electrode and the vinyl sheets perfused with 0.4% saline. The temperature of the saline was controlled by circulating the saline through built-in heat exchangers. The depth of heating was controlled by pairing electrodes of different diameters. When subcutaneous fat was less than 1 cm thick, various deep-seated tumors could be heated to a therapeutic temperature without significant discomfort in the subcutaneous tissue as long as the skin was properly cooled with the cold saline bolus. However, the same cooling method could not prevent the occurrence of pain in subcutaneous tissue in obese patients. The pain usually developed when the temperature of subcutaneous fat 1-2 cm below the skin surface exceeded 42 degrees C. We observed that cooling the human skin surface with 10 degrees C bolus for 20 min could substantially lower the temperature of fat as deep as 2.0-2.5 cm. Therefore, when the subcutaneous tissue was precooled with 10 degrees C saline for 20 min or longer before heating, it was possible to prevent successfully the overheating of subcutaneous fat as thick as 2.0-2.5 cm and to raise the temperature of deep-seated tumors to therapeutic levels.
authors.affiliation: Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: J G
authors.initials: JG
authors.lastname: Rhee
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Osborn
authors.forename: S H
authors.initials: SH
authors.lastname: Levitt
authors.forename: C W
authors.initials: CW
authors.lastname: Song
mesh_terms: D000273:Adipose Tissue; D001831:Body Temperature; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D007036:Hypothermia, Induced; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D013997:Time Factors