Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging.
A series of 99mTc-bis(aminoethanethiol)-fatty acid (99mTc-BAT-fatty acid) analogs were synthesized and evaluated as potential tracers of myocardial metabolism. The BAT-fatty acid precursors were prepared using a new synthetic route that avoids the use of strong reducing agents such as lithium aluminum hydride. Biodistribution studies of the no-carrier-added 99mTc-complexes were conducted in rats using [125I]IPPA as an internal standard. The myocardial uptake of the 99mTc-BAT-fatty acid analogs was significantly less than that of [125I]IPPA and indicates the 99mTc analogs are not suitable candidates for SPECT-based myocardial imaging studies.
Mach
R H
RH
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Kung
H F
HF
Jungwiwattanaporn
P
P
Guo
Y Z
YZ
D000818:Animals; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D006321:Heart / Q000000981:diagnostic imaging*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D005227:Fatty Acids; D015609:Organotechnetium Compounds