title: Muscle damage and recovery in the rabbit tongue following photodynamic therapy with haematoporphyrin derivative.
abstract: To study the effects of photodynamic therapy on the tissues of the tongue, 20 New Zealand White rabbits were injected intravenously with haematoporphyrin derivative. Their tongues and those of 2 controls were illuminated with 100 J/cm2 of red light from a copper vapour-pumped dye laser emitting light at 625 nm. The rabbits were sacrificed at intervals between 2 days and 12 weeks following treatment. Their tongues were examined histologically. Initially there was marked damage to mucosa, muscle and blood vessels. However, this healed by a mixture of regeneration and scarring.
authors.affiliation: Ear, Nose and Throat Department, St Mary's Hospital, London, England.
authors.forename: A F
authors.initials: AF
authors.lastname: Jefferis
authors.forename: E B
authors.initials: EB
authors.lastname: Chevretton
authors.forename: M C
authors.initials: MC
authors.lastname: Berenbaum
mesh_terms: D000818:Animals; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects*; D011817:Rabbits; D014059:Tongue / Q000473:pathology* / Q000503:physiopathology; D014060:Tongue Diseases / Q000139:chemically induced* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology