Action of alpha-tocopherol on vanadium-stimulated lipid peroxidation in rat brain.
Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions. However, administration of alpha-tocopherol (335 or 585 mg/kg) in combination with sodium metavanadate decreased the vanadium-stimulated lipid peroxidation. Results revealed that vanadium directly triggered peroxidative reaction and alpha-tocopherol protected against vanadium-stimulated lipid peroxidation.
Haider
S S
SS
Department of Biochemistry, Al Arab Medical University, Faculty of Medicine, Benghazi, Libya.
el-Fakhri
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates / Q000008:administration & dosage / Q000633:toxicity*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D014810:Vitamin E; D014638:Vanadates