Calpastatin level in spontaneously hypertensive rats.
We studied calpastatin activity in erythrocytes of Milan hypertensive and prehypertensive rats, in their normotensive controls, in F1 and F2 hybrids, and in two inbred strains derived from F2, one hypertensive and the other normotensive. Our results show that the decrease in calpastatin activity observed in Milan hypertensive rats was not caused by hypertension, it was transmitted in a recessive way in heterozygous, and it was not correlated to hypertension.
Soldati
L
L
Dipartimento di Scienze e Tecnologie Biomediche, University of Milano, Italy.
Molinari
I
I
Salardi
S
S
Barber
B R
BR
Ruggiero
M
M
Serra
F
F
Bianchi
G
G
D000818:Animals; D001794:Blood Pressure; D002135:Calcium-Binding Proteins / Q000097:blood*; D002154:Calpain / Q000037:antagonists & inhibitors; D004912:Erythrocytes / Q000201:enzymology; D006579:Heterozygote; D006720:Homozygote; D006973:Hypertension / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; C033668:calpastatin; D002154:Calpain