Nucleolysis of the rabbit intervertebral disc using chondroitinase ABC.
The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.
Henderson
N
N
Institut de Recherche sur les Maladies du Squelette, Berke-sur-Mer, France.
Stanescu
V
V
Cauchoix
J
J
D000818:Animals; D002808:Chondroitin Lyases / Q000627:therapeutic use*; D007403:Intervertebral Disc / Q000473:pathology; D007404:Intervertebral Disc Chemolysis; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D011817:Rabbits; D011859:Radiography; D013997:Time Factors
D002808:Chondroitin Lyases