Isolation and characterization of phosmidosine. A new antifungal nucleotide antibiotic.
A new nucleotide antibiotic, phosmidosine was isolated from a culture filtrate of a newly isolated streptomycete identified as Streptomyces sp. RK-16. HRFAB-MS and elemental analysis established the molecular formula of C16H24N7O8P. 1H, 13C and 31P NMR indicated the presence of a methyl phosphate group and UV spectra were similar to those of 8-hydroxyadenosine. The antibiotic inhibited spore formation of Botrytis cinerea at the concentration of 0.25 micrograms/ml.
Uramoto
M
M
Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
Kim
C J
CJ
Shin-Ya
K
K
Kusakabe
H
H
Isono
K
K
Phillips
D R
DR
McCloskey
J A
JA
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D011685:Purine Nucleotides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013172:Spores, Fungal / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D011685:Purine Nucleotides; C068885:phosmidosine