Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats.
The effects of lappaconitine (LA) and N-deacetyllappaconitine (DLA) on footshock-induced analgesia (FSIA) were studied by the rat tail flick test. Rats subjected to 90 s nonescaping footshock had a significant increase in tail flick latency. Naloxone (4 micrograms, i.c.v.) partially antagonized the FSIA. After 5 consecutive exposures to footshock, rats developed a complete tolerance to the FSIA. The rats tolerant to FSIA showed a cross-tolerance to morphine- but not LA- and DLA-induced analgesia. Administrations of subanalgesic doses of LA and DLA potentiated the FSIA in both intact and adrenalectomized rats.
Guo
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X
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai.
Tang
X C
XC
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000315:Adrenalectomy; D000700:Analgesics; D000818:Animals; D004357:Drug Synergism; D004361:Drug Tolerance; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; C055260:N-deacetyllappaconitine; D009270:Naloxone; D000157:Aconitine; C022150:lappaconitine