Two distinct loci on the short arm of chromosome 16 are involved in myeloid leukemia.
We report a case of acute nonlymphocytic leukemia (ANLL) M5 with the characteristic t(8;16)(p11;p13). The breakpoint in the short arm was regionally localized using nonradioactive in situ hybridization with a series of cosmids of chromosome 16. The results show that a difference exists between the breakpoint in chromosome 16(p13) in this t(8;16) and the breakpoint involved in the short arm in the characteristic inversion 16 (p13;q22)) that occurs in ANLL M4eo. Two different loci appear to be involved in these chromosomal rearrangements.
Wessels
J W
JW
Department of Human Genetics, State University Hospital, Leiden, The Netherlands.
Mollevanger
P
P
Dauwerse
J G
JG
Cluitmans
F H
FH
Breuning
M H
MH
Beverstock
G C
GC
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008677:Metaphase; D010957:Plasmids; D014178:Translocation, Genetic