Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy.
Dilated cardiomyopathy in a family of dogs was found to be associated with decreased myocardial L-carnitine concentrations, when compared with those in control dogs. In 2 affected dogs, treatment with high doses of L-carnitine was associated with increased myocardial L-carnitine concentration and greatly improved health and myocardial function. Withdrawal of L-carnitine supplementation from these dogs resulted in development of myocardial dysfunction and clinical signs of dilated cardiomyopathy.
Keene
B W
BW
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Panciera
D P
DP
Atkins
C E
CE
Regitz
V
V
Schmidt
M J
MJ
Shug
A L
AL
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D002331:Carnitine / Q000172:deficiency* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D008297:Male
D002331:Carnitine