A T-cell neoplasia showing clinicopathologic features of malignant histiocytosis with novel chromosomal abnormalities and N-ras mutation.
Malignant histiocytosis (MH) is a distinct disease entity defined clinically and morphologically. However, the neoplastic origin of MH is not well established. The authors report a 26-year-old woman who showed the typical clinicopathologic features of so-called MH. Cytogenetic and molecular genetic examinations were performed in addition to the morphologic and immunologic approach. The expression of CD2 and T-cell receptor gene rearrangements indicated the T-cell origin of this case. CD30, which is positive for anaplastic large cell lymphoma (Ki-1 lymphoma), was not expressed. The cytogenetic study revealed a clonal chromosome abnormality involving 3q25, 6p21, 11p15, and 11q21. An N-ras point mutation within codon 12 (GGT----GCT) was also detected. These finding indicate that MH defined clinically and morphologically is not a tumor of true histiocytic origin and that it should be reclassified on the basis of immunologic, cytogenetic, and molecular genetic data.
Itoyama
T
T
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
Sadamori
N
N
Sasagawa
I
I
Nakamura
H
H
Tokunaga
S
S
Yamada
Y
Y
Ichimaru
M
M
Yoshida
T
T
Kikuchi
M
M
Takeshima
F
F
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005784:Gene Amplification; D011905:Genes, ras / Q000235:genetics; D054747:Histiocytic Sarcoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008099:Liver / Q000473:pathology; D009154:Mutation / Q000235:genetics; D014170:Transformation, Genetic
D004273:DNA, Neoplasm