Report of a primary lymphoma of the conjunctiva. A lymphoma of MALT origin?
A case of primary conjunctival lymphoma is reported herein. A 47-year-old woman presented with an indolent salmon-coloured tumour of the lower epibulbar conjunctiva. Histologically, we found a lymphoid infiltrate in the epithelium and subepithelium consisting of two components. One component was characterized by centrocytic-like cells and the other by lymphocytic, plasmacytoid and plasma cells. An immunohistological study demonstrated a light chain restricted immunoglobulin expression of the tumour cells as well as some residual polytypic follicles exhibiting reticular dendritic cells. Tumour cell proliferation was associated with a T cell reactive population. A comprehensive investigation (in particular an orbital scan) did not demonstrate any other localization of this lymphoma. Such a lesion raised the question of a possible MALT origin, by analog with MALT-lymphomas of the gastrointestinal tract described by Isaacson and colleagues.
Petrella
T
T
Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Dijon, France.
Bron
A
A
Foulet
A
A
Arnould
L
L
Chirpaz
L
L
Michiels
R
R
D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007128:Immunoglobulin Fragments / Q000032:analysis; D008221:Lymphoid Tissue; D008223:Lymphoma / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009092:Mucous Membrane
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D007128:Immunoglobulin Fragments