Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron emitting radionuclides.
Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.
Finn
R
R
Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Cheung
N K
NK
Divgi
C
C
St Germain
J
J
Graham
M
M
Pentlow
K
K
Larson
S M
SM
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes