title: Twin pregnancy after orthotopic liver transplantation, with exacerbation of chronic graft rejection.
abstract: We report the sixth pregnancy and the first occurrence of twins after liver transplantation, and the second time cyclosporine was used in pregnancy for that indication. The pregnancy was interrupted at 33 weeks, menstrual age, for exacerbation of chronic graft rejection and intrauterine growth retardation of both twins with possible fetal compromise. The neonatal outcomes were good without any detected anomalies except for some neurodevelopmental problems in one twin at the long-term follow-up. The mother underwent a second liver transplant shortly after delivery.
authors.affiliation: Department of Obstetrics and Gynecology, York Hospital, Pennsylvania 17405.
authors.forename: D R
authors.initials: DR
authors.lastname: Grow
authors.forename: N V
authors.initials: NV
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Liss
authors.forename: W T
authors.initials: WT
authors.lastname: Delp
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000209:etiology; D006084:Graft Rejection; D006801:Humans; D016031:Liver Transplantation; D011247:Pregnancy; D011248:Pregnancy Complications; D011272:Pregnancy, Multiple; D014427:Twins
chemical_list: D003524:Cyclosporins