title: The effect of triorthocresyl phosphate, a delayed neurotoxin, on the testes of young broilers.
abstract: Broiler chickens were raised in brooder batteries. At 6 weeks of age 10 chickens were given either a single oral dose of triorthocresyl phosphate (TOCP) at 500 mg/kg body wt. or corn oil as a vehicle. The testes of both groups were examined morphologically and histologically. Changes in characteristics of testicular atrophy in the TOCP-treated group were clearly evident. The results also suggest that TOCP, a delayed neurotoxin, may induce sterility in young male chickens by an unknown mechanism.
authors.affiliation: Department of Animal Science, Michigan State University, East Lansing.
authors.forename: F A
authors.initials: FA
authors.lastname: Fathy
authors.forename: S J
authors.initials: SJ
authors.lastname: Bursian
mesh_terms: D000818:Animals; D001284:Atrophy; D002645:Chickens; D004702:Endocrine Glands / Q000187:drug effects; D008297:Male; D009498:Neurotoxins / Q000633:toxicity*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology; D014317:Tritolyl Phosphates / Q000633:toxicity*
chemical_list: D009498:Neurotoxins; D014317:Tritolyl Phosphates; C025541:tri-o-cresyl phosphate