title: Antidepressant for substance-abusing schizophrenic patients: a minireview.
abstract: 1. Substance abuse and post-psychotic depression are both frequently encountered concomitants of schizophrenia. 2. Substance abuse may be associated with depression-like symptomatology in the course of schizophrenia, and patients may attempt to self-medicate these symptoms with substances of abuse. 3. Antidepressant medication has been found to be a useful adjunct to treatment in at least some cases of substance abuse and some cases of post-psychotic depression. 4. Preliminary evidence exists suggesting that adjunctive antidepressant medication, added to a neuroleptic, may be useful for at least some stable dysphoric substance-abusing schizophrenic patients. 5. It is important to attempt to rule out even subtle neuroleptic-induced akinesia in such patients with a vigorous trial of antiparkinsonian medication.
authors.affiliation: Hillside Hospital Division of the Long Island Jewish Medical Center, N.Y.
authors.forename: S G
authors.initials: SG
authors.lastname: Siris
authors.forename: P C
authors.initials: PC
authors.lastname: Bermanzohn
authors.forename: S E
authors.initials: SE
authors.lastname: Mason
authors.forename: M A
authors.initials: MA
authors.lastname: Shuwall
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D006801:Humans; D012559:Schizophrenia / Q000150:complications*; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy*
chemical_list: D000928:Antidepressive Agents