[Oncogenes as molecular basis of carcinogenesis].
Oncogenes are cellular genes altered by different mechanisms in numerous human tumors. Under this modified form, because of their intervention in the cellular division and differentiation phenomenons, they can play a role in the malignant process. Nevertheless, there is no univocal link between an oncogene alteration and one special type of tumour. Moreover, the role of other biological parameters, which can influence the oncogenes action, must be considered to explain the generation of a cancer.
de La Roche Saint André
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Laboratoire d'oncologie moléculaire, UA 1158 du CNRS, Villejuif, France.
D002455:Cell Division / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003043:Cocarcinogenesis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009857:Oncogenes / Q000235:genetics* / Q000502:physiology