Moderate fish oil intake improves lipemic response to a standard fat meal. A study in 25 healthy men.
To test the hypothesis that conditioning with a practical dose of fish oil will reduce postprandial lipemia, 25 healthy men were matched according to levels of fasting plasma triacylglyceride and allocated to 6 weeks of either fish oil or olive oil supplements (5 g/day). After a 12-hour overnight fast at the termination of the study period, the subjects were given a standard test meal containing 89% of energy as fat (0.73 g fat/kg body wt, polyunsaturated to saturated fat ratio = 0.4). Vitamin A (429 retinol equivalents/kg body wt) was included to endogenously label the chylomicrons. Venous blood samples were obtained before the test meal and hourly thereafter for 8 hours. Chylomicrons were separated by ultracentrifugation, plasma triacylglyceride concentration was determined enzymatically, and retinyl ester levels were measured by liquid chromatography. Postprandially, the fish oil-fed group exhibited mean total and chylomicron triacylglyceride concentrations that were significantly (p less than 0.05) less than those of the olive oil-fed group. Both the fish oil- and olive oil-fed groups had similar rises in chylomicron retinyl esters during the first 2 hours, but after this time the postprandial response of the fish oil-fed group was consistently and significantly (p less than 0.05) less than the response of the olive oil-fed group. Our results suggest that improvement in lipemic response, whether due to enhanced chylomicron clearance or decreased chylomicron entry into the plasma pool, can be achieved at a much lower intake of fish oil than previously reported.
Brown
A J
AJ
Department of Biochemistry, University of Sydney, New South Wales, Australia.
Roberts
D C
DC
D000328:Adult; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D002149:Energy Intake; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D008297:Male; D000069463:Olive Oil; D010349:Patient Compliance; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000097:blood
D002914:Chylomicrons; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D014801:Vitamin A; D002784:Cholesterol