Liver-metastatic human colon carcinoma in immunosuppressed mice.
An experimental liver metastasis model using the HT-29 human colon carcinoma cell line is described. The tumor xenograft in immunosuppressed mice preserved the histological type as well as the human and gastrointestinal markers (HLA-I, CEA). This model seems to be suitable for the development of new therapeutic protocols as well as for the study of metastasizing of a frequent human tumor type.
Györfi
T
T
1st Institute of Pathology, Semmelweis Medical University, Budapest, Hungary.
Timár
J
J
Lapis
K
K
D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002460:Cell Line; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary*; D051379:Mice; D009368:Neoplasm Transplantation; D013154:Spleen / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000276:immunology
D002272:Carcinoembryonic Antigen