[Results of the toxicokinetics of bromoxynil in rats].
The present paper reports on toxicokinetics of bromoxynil after oral administration of two different dosages in male and female rats. The concentrations measured in serum proceed with a terminal half life of 20 h. Differences in sex are expressed in MRT- and AUC-values. The simulated concentration course after multiple dosing corresponds essentially to experimental course (male rats). Toxicokinetics studies of liver and kidney show a saturation kinetics in kidney after oral administration of a high dose (100 mg/kg KM) in case female rats.
Stähler
M
M
Institut für Toxikologie und Okotoxikologie, Biologische Zentralanstalt Berlin.
Gericke
S
S
Beitz
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006540:Herbicides; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D009570:Nitriles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D006540:Herbicides; D009570:Nitriles; C006826:bromoxynil