Cloning of the inhibin/activin beta B subunit gene from the Booroola merino sheep.
The gene encoding the inhibin/activin beta B subunit was isolated from a Booroola Merino ewe which had two copies of the unidentified fertility gene. Both the DNA sequence (greater than 87%) and amino acid sequence (greater than 93%) were highly homologous to those of the human and rat genes. The upstream region of the gene was similar to that of the human and rat genes, having SP1 binding sites and no TATA or CAAT boxes and, like that of the rat, but unlike that of the human gene, no cyclic AMP response elements, suggesting that the beta B gene of sheep and rats is regulated differently from that of man.
Rodgers
R J
RJ
Prince Henry's Institute of Medical Research, South Melbourne, Victoria, Australia.
D028341:Activins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005260:Female; D005298:Fertility / Q000235:genetics; D006801:Humans; D007265:Inhibins / Q000235:genetics*; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D012756:Sheep; D013045:Species Specificity
D028341:Activins; D007265:Inhibins; D004247:DNA