Severe cyanide poisoning from the ingestion of an acetonitrile-containing cosmetic.
A 39-year-old woman ingested 59 mL of Super Nail Nail Off (American International Industries, Hollywood, CA) (containing 99% acetonitrile) in a suicide attempt. Following a latent period of approximately 12 hours, the patient developed cyanide poisoning with severe metabolic acidosis, seizures, and shallow respirations. She responded to the administration of sodium nitrite and sodium thiosulfate, although the administration of nitrite produced bradycardia and hypotension. She developed several relapses over the course of her hospitalization and each time responded to sodium thiosulfate administration. The patient developed hypernatremia from the sodium load given to her; hemodialysis and charcoal hemoperfusion were initiated to correct the hypernatremia and to attempt to remove cyanide, thiocyanate, and acetonitrile. On the fifth hospital day, the patient was fully recovered and was discharged.
Turchen
S G
SG
San Diego Regional Poison Center, University of California San Diego Medical Center 92103.
Manoguerra
A S
AS
Whitney
C
C
D000097:Acetonitriles / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D000328:Adult; D000931:Antidotes / Q000627:therapeutic use; D003358:Cosmetics / Q000032:analysis / Q000506:poisoning*; D003486:Cyanides / Q000097:blood / Q000506:poisoning*; D005260:Female; D006801:Humans; D009262:Nails; D011041:Poisoning / Q000097:blood / Q000628:therapy; D006435:Renal Dialysis; D013406:Suicide, Attempted; D013885:Thiosulfates / Q000627:therapeutic use; D013997:Time Factors
D000097:Acetonitriles; D000931:Antidotes; D003358:Cosmetics; D003486:Cyanides; D013885:Thiosulfates; C017717:sodium thiosulfate; C032159:acetonitrile