title: A cortical lectin from the oocytes of Rutilus rutilus stimulates mitogenic activity and release of soluble factors from human lymphocyte cultures and inhibits protein synthesis in a cell-free system.
abstract: 1. A cortical granule lectin was isolated from vitellogenic oocytes of a bony fish, the roach Rutilus rutilus. 2. The lectin agglutinates human erythrocytes, is specific for L-rhamnose and is composed of different polypeptide subunits. 3. The lectin is the first lectin of animal origin that inhibits protein-synthesis by a rabbit reticulocyte lysate, and is also mitogenic for human lymphocytes.
authors.affiliation: Department of Experimental Pathology, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Licastro
authors.forename: L
authors.initials: L
authors.lastname: Barbieri
authors.forename: A
authors.initials: A
authors.lastname: Krajhanzi
authors.forename: J
authors.initials: J
authors.lastname: Kocourek
authors.forename: F
authors.initials: F
authors.lastname: Stripe
mesh_terms: D000328:Adult; D000818:Animals; D002474:Cell-Free System; D002478:Cells, Cultured; D002850:Chromatography, Gel; D003530:Cyprinidae / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D006384:Hemagglutination; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D037102:Lectins / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D009865:Oocytes / Q000737:chemistry*; D014176:Protein Biosynthesis; D012210:Rhamnose / Q000378:metabolism; D012995:Solubility; D013929:Thromboxane B2 / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D037102:Lectins; D013929:Thromboxane B2; D015232:Dinoprostone; D012210:Rhamnose