The effect of carbohydrates in milk on the absorption of calcium by postmenopausal women.
The purpose of this investigation was to determine if the presence of carbohydrate in milk, either lactose or its hydrolysis products, enhance the bioavailability of calcium (Ca) in milk. Two studies were performed. In study A, fractional Ca absorption was measured in 11 lactose-tolerant postmenopausal women after an oral dose of 47Ca-equilibrated milk formula containing no carbohydrate (NOCHO), lactose (LACTOSE), or an equivalent amount of glucose plus galactose (SUGAR); all participated in three absorption studies in random order. The NOCHO formula contained 10.0 g protein and 217 mg Ca from a combination of milk mineral and protein isolates; the LACTOSE and SUGAR formulae contained in addition 12 g lactose or 6 g glucose plus 6 g galactose, respectively. In study B, fractional Ca absorption was measured in five postmenopausal women after an oral dose of 47Ca-equilibrated skim milk (217 mg Ca) and lactase-treated milk, each with sufficient carbohydrate added to equal 12 g. For both studies, the increase in forearm radioactivity 4 and 8 hours after oral 47Ca administration relative to the increase observed after IV administration was used to estimate fractional Ca absorption. The addition of lactose but not glucose plus galactose to the NOCHO formula enhanced Ca absorption (p less than 0.05). Fractional absorption at 4 hours was 0.386 from the LACTOSE formula compared with 0.310 for both the NOCHO and SUGAR formulae. Those individuals with the lowest absorption in the absence of carbohydrate had the greatest increase with lactose. In contrast, Ca absorption was the same from skim milk as from lactase-treated skim milk (study B).(ABSTRACT TRUNCATED AT 250 WORDS)
Schuette
S A
SA
Department of Radiology, University of Chicago, Illinois 60637.
Yasillo
N J
NJ
Thompson
C M
CM
D000328:Adult; D000368:Aged; D000818:Animals; D002132:Calcium Radioisotopes; D002136:Calcium, Dietary / Q000493:pharmacokinetics*; D004040:Dietary Carbohydrates / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007785:Lactose / Q000494:pharmacology; D007789:Lactose Tolerance Test; D008593:Menopause / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D008892:Milk / Q000737:chemistry*; D009753:Nutritive Value; D011897:Random Allocation; D013054:Spectrophotometry, Atomic
D002132:Calcium Radioisotopes; D002136:Calcium, Dietary; D004040:Dietary Carbohydrates; D007785:Lactose