[Amphotericin B resistant severe hepato-splenic candidiasis, responding to fluconazole, in a patient following bone marrow transplantation].
A 23 year old woman with Philadelphia-positive chronic granulocytic leukaemia underwent a 3/4 HLA identical bone marrow transplantation. During the neutropenic period, a septic condition developed which was caused by Candida albicans. Administration of Amphotericin B for 63 day was ineffective including an attempt to give the drug through the truncus coeliacus. Finally the sepsis disappeared during fluconazole treatment.
Jakab
K
K
Semmelweis orvostudományi Egyetem, Budapest.
Kelemen
E
E
Váradi
G
G
Török
I
I
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D013158:Splenic Diseases / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology
D000666:Amphotericin B; D015725:Fluconazole