Non-mutagenicity of 4 metabolites of di(2-ethylhexyl)phthalate (DEHP) and 3 structurally related derivatives of di(2-ethylhexyl)adipate (DEHA) in the Salmonella mutagenicity assay.
Four metabolites of the rat liver carcinogen di(2-ethylhexyl)phthalate (DEHP) (mono-(2-ethylhexyl)phthalate, mono-(2-ethyl-5-hydroxyhexyl)phthalate, mono-(2-ethyl-5-oxohexyl)phthalate, and mono-(5-carboxy-2-ethylpentyl)phthalate) and 3 structurally related derivatives of di(2-ethylhexyl)adipate (DEHA) (mono-(2-ethylhexyl)adipate, mono-(2-ethyl-5-hydroxyhexyl)adipate, and mono-(2-ethyl-5-oxohexyl)adipate) were tested for mutagenicity in the Ames assay using Salmonella typhimurium strains TA97, TA98, TA100, and TA102, with and without a metabolic activation preparation. Aroclor 1254-induced rat liver S9 and DEHP-induced rat liver S9 were used. Concentrations of these compounds up to 1000 micrograms/plate were negative with all tester strains in the presence or absence of metabolic activation.
Dirven
H A
HA
Department of Toxicology, University of Nijmegen, The Netherlands.
Theuws
J L
JL
Jongeneelen
F J
FJ
Bos
R P
RP
D000272:Adipates / Q000633:toxicity*; D000818:Animals; D004247:DNA / Q000187:drug effects*; D004051:Diethylhexyl Phthalate / Q000633:toxicity* / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains
D000272:Adipates; C013966:dioctyl adipate; D004247:DNA; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate