title: Elimination of transient dendritic spines in ipsilaterally projecting retinal ganglion cells in rats with neonatal unilateral thalamotomy.
abstract: Using the DiI and intracellular Lucifer Yellow labeling techniques in the rat, we have demonstrated that the unilateral neonatal thalamotomy does not result in retention of transient dendritic spines of ipsilaterally projecting retinal ganglion cells (IPRGCs), although the thalamotomy is known to retain the normally transient IPRGCs (Chan et al., Dev. Brain Res., 49 (1989) 265-274). These results suggest that the process of elimination or retraction of transient dendritic spines occurs in retinal ganglion cells during development regardless of whether they make connections with appropriate or inappropriate loci in the visual targets, and/or a decrease in interactions with neighboring retinal ganglion cells.
authors.affiliation: Department of Anatomy, University of Hong Kong.
authors.forename: K C
authors.initials: KC
authors.lastname: Lau
authors.forename: K F
authors.initials: KF
authors.lastname: So
authors.forename: D
authors.initials: D
authors.lastname: Tay
authors.forename: L S
authors.initials: LS
authors.lastname: Jen
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002232:Carbocyanines; D003712:Dendrites / Q000648:ultrastructure*; D007546:Isoquinolines; D051381:Rats; D011919:Rats, Inbred Strains; D012165:Retinal Ganglion Cells / Q000648:ultrastructure*; D013788:Thalamus / Q000502:physiology*
chemical_list: D002232:Carbocyanines; D007546:Isoquinolines; C024286:3,3'-dioctadecylindocarbocyanine; C017475:lucifer yellow