Droperidol prevents serotonin-induced bronchospasm in the guinea pig.
The effects of droperidol on bronchoconstriction induced by serotonin (5-HT) were studied in mechanically ventilated, paralyzed guinea pigs that had been anesthetized with pentobarbital. Droperidol did not modify the resting bronchial tone but prevented the bronchoconstrictor effects of 5-HT in a dose-related manner. Pretreatment with propranolol, hexamethonium, or prazosin did not alter the protective effects of droperidol on 5-HT-induced bronchoconstriction. The bronchoconstrictor responses to histamine or acetylcholine were not affected by droperidol. These results suggest that the protective effects of droperidol on 5-HT-induced bronchoconstriction are mediated through 5-HT receptor blockade on bronchial smooth muscle.
Gentil
B
B
Département de Physiologie, Unité INSERM U 296, Hôpital Henri Mondor, Créteil, France.
Macquin-Mavier
I
I
Lienhart
A
A
Harf
A
A
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000517:prevention & control*; D016084:Bronchoconstriction / Q000187:drug effects*; D004329:Droperidol / Q000627:therapeutic use*; D006168:Guinea Pigs; D006632:Histamine / Q000633:toxicity; D006633:Histamine Antagonists / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D006633:Histamine Antagonists; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D006632:Histamine; D000109:Acetylcholine; D004329:Droperidol