Cerebrospinal fluid anti-cardiolipin antibodies in neurological diseases.
We studied, with sensitive ELISAs, the anti-cardiolipin antibodies of the G, A, and M classes in the cerebrospinal fluid (CSF) and serum of 179 neurological patients. The CSF and serum of 2 systemic lupus erythematosus (SLE) patients presented IgG anti-cardiolipin antibodies in corresponding levels. Anti-cardiolipin antibodies were produced within the central nervous system in neurosyphilis (A and M classes), in some patients affected by multiple sclerosis (G or M class), in two cases of Guillain-Barré syndrome (G and A classes), and in one AIDS patient (G class). The CSF anti-cardiolipin antibodies detected in our study suggest a local immune reaction against brain phospholipids in SLE and in human demyelinating disorders.
Lolli
F
F
Dipartimento di Scienze Neurologiche e Psichiatriche, Università degli Studi, Firenze, Italy.
Matá
S
S
Baruffi
M C
MC
Amaducci
L
L
D000906:Antibodies / Q000134:cerebrospinal fluid*; D002308:Cardiolipins / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology
D000906:Antibodies; D002308:Cardiolipins; D007136:Immunoglobulins