title: Highly polymorphic domains of the human serum amyloid A (SAA) gene GSAA1.
abstract: The DNA of the human serum amyloid A (SAA) gene GSAA1 contains several repetitive regions within its introns. We have studied length variations at one such region in the 2nd intron by selective amplification using the polymerase chain reaction (PCR) and defined oligonucleotide primers. The lengths of the repetitive regions frequently differ between individual chromosomes and can be transmitted as Mendelian markers, making them useful for genetic linkage analysis.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: G H
authors.initials: GH
authors.lastname: Sack
authors.forename: C C
authors.initials: CC
authors.lastname: Talbot
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D000685:Serum Amyloid A Protein / Q000235:genetics*
chemical_list: D000685:Serum Amyloid A Protein