Activity of urethane in rat and mouse micronucleus tests after oral administration.
Urethane is readily detectable as an in vivo clastogen in the micronucleus test after oral administration to both rats and mice. Mice appear to be the more sensitive species. Positive results were obtained irrespective of the strain (CD1, CRH) or dosing regimen (single, triple-dose) used.
Westmoreland
C
C
Genetic and Reproductive Toxicology Department, Glaxo Group Research Ltd., Ware, Hert, Great Britain.
Plumstead
M
M
Gatehouse
D
D
D000284:Administration, Oral; D000818:Animals; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012680:Sensitivity and Specificity; D014520:Urethane / Q000008:administration & dosage*
D009153:Mutagens; D014520:Urethane