title: Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole.
abstract: Reaction of 3-amino derivatives of the nematocides tetramisole and levamisole with variously substituted benzoylisocyanates gave a series of benzoylureas I which were tested for activity against helminths and ectoparasites. Compounds bearing 2,6-difluoro and 4-trifluoromethyl substituents had potent nematocidal activity in both mice and sheep. No antiectoparasitic activity was observed.
authors.affiliation: Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304.
authors.forename: R J
authors.initials: RJ
authors.lastname: Weikert
authors.forename: S
authors.initials: S
authors.lastname: Bingham
authors.forename: M A
authors.initials: MA
authors.lastname: Emanuel
authors.forename: E B
authors.initials: EB
authors.lastname: Fraser-Smith
authors.forename: D G
authors.initials: DG
authors.lastname: Loughhead
authors.forename: P H
authors.initials: PH
authors.lastname: Nelson
authors.forename: A L
authors.initials: AL
authors.lastname: Poulton
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007978:Levamisole / Q000031:analogs & derivatives; D008297:Male; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy; D012756:Sheep; D013329:Structure-Activity Relationship; D013773:Tetramisole / Q000031:analogs & derivatives
chemical_list: D000871:Anthelmintics; D007978:Levamisole; D013773:Tetramisole