Myocardial remodeling and pathologic hypertrophy.
The hallmark of myocardial hypertrophy associated with congestive failure is interstitial fibrosis. How does the fibrosis develop, and what can be done about it? Hormonal and hemodynamic factors are examined. Experimental studies with ACE inhibitors or aldosterone receptor antagonists suggest that the fibrosis may be prevented or reversed.
Weber
K T
KT
Department of Medicine, University of Missouri-Columbia School of Medicine.
Brilla
C G
CG
Janicki
J S
JS
D000818:Animals; D009202:Cardiomyopathies / Q000503:physiopathology*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000503:physiopathology; D004719:Endomyocardial Fibrosis / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D051381:Rats