title: L-669,262, a potent HMG-CoA reductase inhibitor.
abstract: The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Inc., Rahway, NJ 07065.
authors.forename: H
authors.initials: H
authors.lastname: Joshua
authors.forename: M S
authors.initials: MS
authors.lastname: Schwartz
authors.forename: K E
authors.initials: KE
authors.lastname: Wilson
mesh_terms: D000818:Animals; D005285:Fermentation; D006900:Hydroxylation; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009615:Nocardia / Q000378:metabolism*; D051381:Rats; D019821:Simvastatin; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C068819:L 669262; D008148:Lovastatin; D019821:Simvastatin