Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney.
Infiltrating cells were analysed in renal biopsy tissue obtained from a 15-year-old girl with acute interstitial nephritis and uveitis using monoclonal antibodies specific for mononuclear cell surface markers. The interstitial infiltrates consisted mainly of T cells and monocytes/macrophages. A considerable proportion of the infiltrating cells were identified by a monoclonal antibody against the interleukin-2 receptor, indicating that a majority of those immune cells are activated. This observation documents the participation of cell-mediated immune injury in interstitial nephritis associated with uveitis.
Yoshioka
K
K
Department of Paediatrics, Kinki University School of Medicine, Osaka-sayama, Japan.
Takemura
T
T
Kanasaki
M
M
Akano
N
N
Maki
S
S
D000208:Acute Disease; D000293:Adolescent; D001706:Biopsy; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000276:immunology; D013577:Syndrome; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014605:Uveitis / Q000473:pathology*
D015375:Receptors, Interleukin-2