title: Correlation between histochemically assessed hormonal receptor content and clinical course in breast cancer. Presentation of 1,005 cases.
abstract: Lee's histochemical method was used to assess hormonal receptors in 1,005 patients with breast cancer. Patients were from 8 oncological departments in northern Italy. The group was subdivided into four subgroups in relation to menopausal status and presence or absence of axillary node metastasis. Overall survival (OS) and disease-free survival (DFS) were analysed in all subgroups in relation to receptorial status. We observed: (1) when hormonal receptors are present, OS and DFS are longer in all subgroups; (2) the presence of hormonal receptors influences favourably both DFS and OS, but it seems to play a more important role for DFS; (3) the positive receptorial status is a better prognostic factor in groups without axillary node metastasis, especially in premenopausal patients. We conclude that the histochemical assessment of hormonal receptors is a valid method for the prognostic evaluation of patients with breast cancer.
authors.affiliation: Divisione di Oncologia Medica Falck, Ospedale Cà Granda-Niguarda, Milano, Italia.
authors.forename: O
authors.initials: O
authors.lastname: Gottardi
authors.forename: C
authors.initials: C
authors.lastname: Baiocchi
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
authors.forename: L
authors.initials: L
authors.lastname: Franchi
authors.forename: M
authors.initials: M
authors.lastname: Gambacorta
authors.forename: G
authors.initials: G
authors.lastname: Landonio
authors.forename: N
authors.initials: N
authors.lastname: Pinna
authors.forename: E
authors.initials: E
authors.lastname: Ghislandi
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality; D006651:Histocytochemistry; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012189:Retrospective Studies
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone