The genetic basis of negative selection of Tcrb-V11+ T cells.
Non-H-2 genes responsible for negative selection of Tcrb-V11+ T cells were examined using backcross mice of various strains with C58, which does not delete Tcrb-V11+ T cells. Two independently segregating genes were found: one leading to partial deletion was closely linked to Ly-2/Ly-3 on chromosome 6, and the second giving virtually complete deletion has not yet been mapped. The A strain had only the former, whereas BALB/c, BALB.K, B10.BR, CBA-T6, C3H/He, and DBA/2 expressed both of these genes. Although a gene(s) of the NIH strain led only to partial deletion, the chromosomal localization of the gene(s) has not yet been determined: no informative polymorphic molecules are expressed from genes on chromosome 6 of this strain.
Tomonari
K
K
Transplantation Biology Section, MRC Clinical Research Centre, Middlesex, England.
Fairchild
S
S
D000818:Animals; D002872:Chromosome Deletion; D006183:H-2 Antigens / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell