title: Rifampin and ansamycin interactions with cyclosporine after renal transplantation.
abstract: Cyclosporine whole blood concentrations are routinely monitored to help ensure optimal therapy. Several drugs have been shown to alter cyclosporine disposition by altering hepatic metabolism. Rifampin, a potent enzyme inducer, has been demonstrated to increase cyclosporine clearance. The effects of ansamycin, a chemically related investigational antibiotic, on cyclosporine disposition, have not been previously published. We report a renal transplant patient receiving cyclosporine and consecutive therapy with rifampin and ansamycin. When compared to rifampin, ansamycin's effect on cyclosporine disposition appeared to be delayed and of less magnitude. Further characterization of this interaction is required. Until this issue is resolved, we would advise careful monitoring of cyclosporine blood levels in patients receiving either rifampin or ansamycin in concert with cyclosporine.
authors.affiliation: Department of Pharmacy, Vancouver General Hospital, British Columbia, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Vandevelde
authors.forename: A
authors.initials: A
authors.lastname: Chang
authors.forename: D
authors.initials: D
authors.lastname: Andrews
authors.forename: W
authors.initials: W
authors.lastname: Riggs
authors.forename: P
authors.initials: P
authors.lastname: Jewesson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003524:Cyclosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D016030:Kidney Transplantation; D047029:Lactams, Macrocyclic; D008099:Liver / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D047029:Lactams, Macrocyclic; D012293:Rifampin