title: [No increase in the incidence of breast carcinoma with subcutaneous administration of estradiol].
abstract: Between 1972 and mid-1990 the frequency of breast cancer was studied in a group of 261 mostly premenopausal women of the gynaecological department of the Municipal Hospital in The Hague, the Netherlands. All the patients had had a total hystero-adnexectomy after which they were substituted with estradiol implants. On the basis of a stratified lifetable giving the cumulative incidence of breast cancer in the Netherlands, an expected incidence of 2 per 1000 person-years was estimated for the observed group (mean observation period: 8.25 years). There were three cases of breast cancer in the observed group. This means an incidence density of 1.4 per 1000 person-years. It is concluded that this form of oestrogen substitution does not increase the risk of breast cancer.
authors.affiliation: Ziekenhuis Levenburg, afd. Gynaecologie, 's-Gravenhage.
authors.forename: E M
authors.initials: EM
authors.lastname: Davelaar
authors.forename: G
authors.initials: G
authors.lastname: Gerretsen
authors.forename: J
authors.initials: J
authors.lastname: Relyveld
mesh_terms: D001943:Breast Neoplasms / Q000139:chemically induced*; D004343:Drug Implants / Q000009:adverse effects; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010052:Ovariectomy
chemical_list: D004343:Drug Implants; D004958:Estradiol