[Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis].
From January 1978 to August 1990, Staphylococcus aureus bacteremia (SAB) were identified in 31 patients with hematological malignancies at Jichi Medical School hospital. Mortality due to SAB was 48.4% (15/31). Of the variables analyzed, four factors were significantly associated with a poor prognosis; elderly age (p = 0.015), high granulocyte count (more than 500/microliters) (p = 0.015), presence of DIC (p = 0.011) and presence of pneumonia (p = 0.023). The incidence of methicillin-resistant SAB was 32.3% (10/31) and the first patient developed in 1985. Although not statistically significant, there was a trend of higher mortality for methicillin-resistant SAB (70%) than for methicillin-sensitive SAB (38.1%). Most strains of methicillin-resistant Staphylococcus aureus were sensitive to minocycline, chloramphenicol and vancomycin.
Itoh
M
M
Department of Medicine, Jichi Medical School.
Yoshida
M
M
Kurata
H
H
Imagawa
S
S
Hoshino
M
M
Tsunoda
J
J
Ema
H
H
Tsunoda
S
S
Suzuki
T
T
Komatsu
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002701:Chloramphenicol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D008911:Minocycline / Q000494:pharmacology; D011379:Prognosis; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000209:etiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology
D002701:Chloramphenicol; D014640:Vancomycin; D008911:Minocycline