title: [Distribution of inhaled aerosol using nasal nebulizer].
abstract: In this paper, we examined distribution and deposition of inhaled 99mTc aerosols in human respiratory tract, nebulization equipment and expired aerosols. Jet nebulizers were used and aerosols were inhaled through the nose. Results were as follows: 1. On normal breathing, deposition rate of human respiratory tracts in normal subjects were 22% of total dosage and there was no difference from sinusitis group. But, deposition rate of nasal cavity was higher than in sinusitis group normal in group. 2. In normal subjects, there was no influence of breathing pattern to deposition rate of nasal cavity. 3. Distribution of the lung was significantly increased on deep breathing in both groups. 4. Residual volume of nebulizer bottle were about 50% of total dosage.
authors.affiliation: Department of Otolaryngology, Ohashi Hospital, Toho University School of Medicine, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Ogoshi
authors.forename: N
authors.initials: N
authors.lastname: Usui
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols; D006801:Humans; D009330:Nebulizers and Vaporizers; D012137:Respiratory System / Q000378:metabolism*; D013667:Technetium / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D000336:Aerosols; D013667:Technetium