5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome.
Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53.8 mg). Eight eyes had undergone prior unsuccessful trabeculectomy. Four eyes had intraocular pressure (IOP) less than or equal to 21 mmHg on zero to two glaucoma medications after 6 to 54 months of follow-up (mean, 25.3 months). Five eyes required repeat surgery within 2 to 13 months and were considered failures. All five eyes that failed received a Molteno drainage implant. Progressive endothelial proliferation may explain late onset bleb failure and the relative ineffectiveness of 5-FU in this condition.
Wright
M M
MM
Bascom Palmer Eye Institute, University of Miami, FL 33101.
Grajewski
A L
AL
Cristol
S M
SM
Parrish
R K
RK
D000328:Adult; D002387:Cataract Extraction; D003228:Conjunctiva / Q000187:drug effects; D003316:Corneal Diseases / Q000188:drug therapy* / Q000601:surgery; D004728:Endothelium, Corneal; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D015948:Keratoplasty, Penetrating; D007910:Lenses, Intraocular; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy* / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D013577:Syndrome; D014130:Trabeculectomy
D005472:Fluorouracil