On the paradox of insulin-induced hyperandrogenism in insulin-resistant states.
I have reviewed recent studies that shed light on the paradox of insulin-induced ovarian hyperandrogenism in insulin-resistant states. Depending on the circumstances of the particular syndrome, insulin could act on the ovaries of insulin-resistant patients by activating IGF-I receptors, insulin receptors, hybrid insulin/IGF-I receptors, or any combination of these receptors. Further studies will uncover precise mechanisms of insulin-induced ovarian hyperstimulation in specific syndromes of insulin resistance.
Poretsky
L
L
Department of Medicine, Cabrini Medical Center, New York, New York 10003.
D000728:Androgens / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism / Q000502:physiology
D000728:Androgens; D007328:Insulin