[Renal incompatibility with antibacterial drugs: diagnosis and preventive measures].
Renal intolerance as a consequence of antibacterial therapy shows up in different ways. It is important to frequently control urine, serum creatinine and urea. Pre-existing renal disease and illnesses which need intensive care treatment and therapy with potentially nephrotoxic drugs require a careful application of antibiotics with nephrotoxic properties, e.g. aminoglycosides. Therefore drug monitoring is mandatory. The administration of NSAIDS should be avoided, because they impair the glomerular filtration rate. In addition, the excessive use of diuretics should be prevented. It is recommended that modern beta-lactam antibiotics with their wide antibacterial spectrum and their good renal compatibility should be preferred for therapy of bacterial infections under the conditions mentioned above.
Andrassy
K
K
Med. Universitätsklinik, Sektion Nephrologie, Heidelberg, Germany.
D000890:Anti-Infective Agents / Q000009:adverse effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D009395:Nephritis, Interstitial / Q000139:chemically induced
D000890:Anti-Infective Agents