title: Familial stomatocytosis--hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond).
abstract: A newly recognised disease, which we have given the provisional name of familial stomatocytosis-hypertrophic gastritis (FSHG), is described in two families of dogs of the Drentse partrijshond breed. The affected dogs consisted of 3 females and 5 males, 3 to 19 (mean 9.5) months of age at admission. The main clinical problems were diarrhoea, icterus, and ataxia and paresis of the pelvic limbs. Laboratory evaluation revealed abnormal red cell shape (stomatocytosis), increased osmotic fragility, haemolytic anaemia, and increased liver enzymes and serum bilirubin. Gastroscopic and histopathologic examination of the gastric mucosa revealed hypertrophic gastritis resembling Ménétrier's disease in man. Histologic findings in the liver were suggestive of progressive liver disease. Cysts were found in the kidneys of the five oldest patients. Electroneurography in 2 dogs revealed polyneuropathy. In the parents of 2 patients (sister and brother), there were no clinical or laboratory abnormalities. An autosomal recessive hereditary defect of lipid metabolism is suspected.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Slappendel
authors.forename: I
authors.initials: I
authors.lastname: van der Gaag
authors.forename: J J
authors.initials: JJ
authors.lastname: van Nes
authors.forename: T S
authors.initials: TS
authors.lastname: van den Ingh
authors.forename: R P
authors.initials: RP
authors.lastname: Happé
mesh_terms: D000818:Animals; D001259:Ataxia / Q000662:veterinary; D001921:Brain / Q000473:pathology; D001947:Breeding; D004283:Dog Diseases / Q000097:blood / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D004576:Electromyography / Q000662:veterinary; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D005758:Gastritis, Hypertrophic / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005773:Gastroscopy / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009426:Netherlands; D010375:Pedigree; D013270:Stomach / Q000473:pathology; D013577:Syndrome