title: Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene.
abstract: The presence of a previously unidentified exon upstream of the originally described human oestrogen receptor (hOR) gene is demonstrated. This is shown to be spliced to the 5' untranslated region of the previously designated exon I. The resulting genomic structure of the human gene is thus in agreement with the structure of the mouse OR gene and highlights the conservation of an 18 amino acid upstream open-reading frame formed from the above splicing event. Taken in conjunction with previous publications this would suggest that the hOR gene is a complex transcriptional unit that contains two promoters.
authors.affiliation: Department of Microbiology, University College Galway, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Keaveney
authors.forename: J
authors.initials: J
authors.lastname: Klug
authors.forename: M T
authors.initials: MT
authors.lastname: Dawson
authors.forename: P V
authors.initials: PV
authors.lastname: Nestor
authors.forename: J G
authors.initials: JG
authors.lastname: Neilan
authors.forename: R C
authors.initials: RC
authors.lastname: Forde
authors.forename: F
authors.initials: F
authors.lastname: Gannon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D005091:Exons; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D011960:Receptors, Estrogen / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004274:DNA, Recombinant; D011960:Receptors, Estrogen; D004247:DNA