title: Spatial control of gut-specific gene expression during Caenorhabditis elegans development.
abstract: The nematode Caenorhabditis elegans was transformed with constructs containing upstream deletions of the gut-specific ges-1 carboxylesterase gene. With particular deletions, ges-1 was expressed, not as normally in the gut, but rather in muscle cells of the pharynx (which belong to a sister lineage of the gut) or in body wall muscle and hypodermal cells (which belong to a cousin lineage of the gut). These observations suggest that gut-specific gene expression in C. elegans involves not only gut-specific activators but also multiple repressors that are present in particular nongut lineages.
authors.affiliation: Department of Medical Biochemistry, University of Calgary, Alberta, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Aamodt
authors.forename: M A
authors.initials: MA
authors.lastname: Chung
authors.forename: J D
authors.initials: JD
authors.lastname: McGhee
mesh_terms: D000818:Animals; D002107:Caenorhabditis / Q000196:embryology / Q000201:enzymology / Q000235:genetics*; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics; D004064:Digestive System / Q000196:embryology / Q000201:enzymology; D004625:Embryo, Nonmammalian / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic; D008954:Models, Biological; D009928:Organ Specificity
chemical_list: D004247:DNA; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase