Temporal sequence of neuroendocrine events associated with the transfer of male golden hamsters from a stimulatory to a nonstimulatory photoperiod.
The transfer of male golden hamsters from long day (LD) to short day (SD) conditions results in gonadal atrophy within 8 weeks and significant reductions in LH, FSH, and prolactin (Prl) secretion as early as 4 weeks. Changes in hypothalamic neurotransmitter metabolism precede these changes in pituitary hormone secretion. Thus median eminence norepinephrine (NE) turnover declines steadily after SD exposure, although the differences as compared to turnover in LD hamsters are not significant until Week 4. Median eminence dopamine (DA) turnover is reduced significantly within 1 week. Turnover of NE and DA in the medial basal hypothalamus also changes significantly within 1 or 2 weeks of SD exposure, but the changes are not maintained through Week 8, despite continued reductions in levels of circulating LH, FSH, and Prl. Reductions in median eminence NE metabolism appear to be responsible for the decrease in LH and FSH release. Initial decreases in Prl release appear to be hypothalamic in origin, but the hypothalamic factor(s) responsible for this change is not evident. An increase in inhibitory input from tuberoinfundibular dopaminergic neurons is clearly not involved.
Steger
R W
RW
Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901-6512.
Bartke
A
A
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D006224:Cricetinae; D005837:Genitalia, Male / Q000033:anatomy & histology; D006728:Hormones / Q000097:blood; D066298:In Vitro Techniques; D008027:Light; D008297:Male; D008647:Mesocricetus; D009490:Neurosecretory Systems / Q000502:physiology*; D010507:Periodicity; D011388:Prolactin / Q000378:metabolism; D012098:Reproduction / Q000502:physiology; D012621:Seasons
D002395:Catecholamines; D006728:Hormones; D011388:Prolactin