[Comparative studies on cytokinesis-block and conventional micronucleus test in human lymphocyte cultured in vitro. I. Effects of medium and low doses of gamma-rays].
In this paper the authors have studied relationship between gamma-ray dose and mean MNCF measured separately by Cytokinesis-block and conventional micronucleus test (BC- and C-MNT) to increase the sensitivity of MNT in human lymphocyte and to explore the possibility of using MNT in human lymphocyte as biodosimetry. The main results show that using C-MNT low dose of gamma-rays (0.1, 0.3 GYs) could increase mean MNCF as compared with control; but using BC-MNT mean MNCF could not be increased. With medium dose of gamma-rays (0.7-3.1 GYs) mean MNCF measured by BC-MNT is more significant than that measured by C-MNCT.
Xue
K X
KX
Cancer Institute of Jiangsu Province, Nanjing.
Shen
Z L
ZL
D000328:Adult; D002455:Cell Division; D003470:Culture Media; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D015162:Micronucleus Tests; D011829:Radiation Dosage
D003470:Culture Media