Von Hippel-Lindau disease and erythrocytosis: radioimmunoassay of erythropoietin in cyst fluid from a brainstem hemangioblastoma.
A 59-year-old woman with von Hippel-Lindau disease developed erythrocytosis and a recurrent intracranial hemangioblastoma. Radioimmunoassay showed an elevated level of erythropoietin in her serum. Cyst fluid from the tumor also contained erythropoietin, concentrated a thousandfold relative to the serum level. Production of erythropoietin by hemangioblastomas may explain the erythrocytosis present in some patients with von Hippel-Lindau disease.
Horton
J C
JC
Department of Neurological Surgery, University of California, San Francisco 94143-0350.
Harsh
G R
GR
Fisher
J W
JW
Hoyt
W F
WF
D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D001933:Brain Stem / Q000473:pathology*; D004921:Erythropoietin / Q000032:analysis*; D005260:Female; D006394:Hemangiosarcoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011086:Polycythemia / Q000150:complications* / Q000503:physiopathology; D011863:Radioimmunoassay; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
D004921:Erythropoietin