title: The association of age with aspirin esterase activity in human liver.
abstract: The activity of the phase 1 enzyme aspirin esterase was studied in liver tissue from 16 patients, aged 45-88 years. No correlation between age and enzyme activity was found in post-mitochondrial, cytosolic and microsomal fractions. These results provide further evidence that age is not a major determinant of the activity of hepatic drug-metabolizing enzymes in man.
authors.affiliation: Department of Medicine (Geriatrics), The University, Newcastle upon Tyne.
authors.forename: C
authors.initials: C
authors.lastname: Yelland
authors.forename: J
authors.initials: J
authors.lastname: Summerbell
authors.forename: E
authors.initials: E
authors.lastname: Nicholson
authors.forename: B
authors.initials: B
authors.lastname: Herd
authors.forename: H
authors.initials: H
authors.lastname: Wynne
authors.forename: K W
authors.initials: KW
authors.lastname: Woodhouse
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003600:Cytosol / Q000201:enzymology; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic / Q000502:physiology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D012016:Reference Values
chemical_list: D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase