A muscarine-activated voltage-independent K+ channel in cultured bullfrog sympathetic neurones.
In cultured bullfrog sympathetic neurones, cell-attached patch clamp revealed a voltage-independent K+ channel having a conductance of 46-113 pS at an external K+ of 2-120 mM. Muscarine (10-20 microM), applied to the cell membrane outside a recording pipette, increased its open probability and mean open time in an atropine-sensitive manner. This muscarine-activated K+ channel could underlie some of the muscarinic inhibitory postsynaptic potentials in both central and peripheral nervous systems.
Tanaka
K
K
Department of Physiology, Saga Medical School, Japan.
Koyano
K
K
Kuba
K
K
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects*; D011892:Rana catesbeiana; D011894:Rana pipiens
D015221:Potassium Channels; D001285:Atropine; D009116:Muscarine