Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse chromosome 11.
Southern blot analysis of DNAs from Chinese hamster x mouse and rat x mouse somatic cell hybrids showed that the mouse gene encoding androgen-binding protein/sex hormone-binding globulin (ABP-SHBG) is on Chromosome 11. Progeny from an intersubspecies backcross were analyzed to position this locus, termed Shbg, between Il-3 and Int-4 in the middle of this chromosome. Shbg is thus closely linked to several neurological mutations, one of which, Tr, is also associated with male sterility. The recent finding that ABP-SHBG is found throughout the rat brain raises the possibility that one of these mutations may be due to a defect in Shbg.
Joseph
D R
DR
Department of Pediatrics, University of North Carolina, Chapel Hill.
Adamson
M C
MC
Kozak
C A
CA
D000727:Androgen-Binding Protein / Q000235:genetics*; D000818:Animals; D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012738:Sex Hormone-Binding Globulin / Q000235:genetics*
D000727:Androgen-Binding Protein; D012738:Sex Hormone-Binding Globulin