Evaluation of the ability of a new long-acting androgen ester to maintain accessory gland function in castrated rhesus monkey.
The ability of 40 mg of milled suspension of a new long-acting androgen ester (20 Aet-1) to restore and maintain accessory gland function was compared with that of testosterone enanthate (TE) in castrated adult rhesus monkeys. Castration did not abolish the ejaculatory response since only two animals did not void semen in the postcastration period. A single intramuscular injection of 40 mg of these compounds stimulated accessory gland function at levels lower than in the pretreatment period. 20 Aet-1-induced stimulation of prostatic acid phosphatase activity never exceeded control levels unlike that induced by testosterone enanthate which caused hyperstimulation on day 21 of drug treatment. In terms of support of accessory gland function, 20 Aet-1 would appear to offer hope of being a successful androgen for supplementation therapy in male animals.
Rajalakshmi
M
M
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
Ramakrishnan
P R
PR
Kaur
J
J
Sharma
D N
DN
Pruthi
J S
JS
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004542:Ejaculation / Q000187:drug effects; D005632:Fructose / Q000032:analysis; D005837:Genitalia, Male / Q000187:drug effects / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009919:Orchiectomy; D012661:Semen / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
C050320:testosterone 4-n-butylcyclohexylcarboxylic acid; D005632:Fructose; D013739:Testosterone; C004648:testosterone enanthate; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase