title: Clinical studies with B72.3 in ovarian cancer and probe-guided tumor localization.
abstract: The present study reports the findings of radiolabeled monoclonal antibody (MoAb) application in the post-operative monitoring of patients with ovarian carcinoma. We studied 40 patients with histologically confirmed ovarian cancer using two radiolabeled MoAbs, 131I-B72.3 and 131I-OC125. Antibody scans showed that high uptake of radiolabeled MoAb was consistently associated with presence of disease confirmed by computed tomography, ultrasonography, clinical evolution and in a few cases by second look procedures. Computed tomography could not discriminate well between post-operative fibrosis and tumor lesion especially when localized in the peritoneum. We conclude that radiolabeled MoAbs, computed tomography and serum tumor markers are complementary in the postoperative monitoring of patients with ovarian carcinoma.
authors.affiliation: Nuclear Medicine Department, National Cancer Institute, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Del Vecchio
authors.forename: L
authors.initials: L
authors.lastname: Camera
authors.forename: A
authors.initials: A
authors.lastname: Petrillo
authors.forename: G
authors.initials: G
authors.lastname: Esposito
authors.forename: G
authors.initials: G
authors.lastname: Frasci
authors.forename: R V
authors.initials: RV
authors.lastname: Iaffaioli
authors.forename: A R
authors.initials: AR
authors.lastname: Bianco
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000097:blood / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007457:Iodine Radioisotopes; D008991:Monitoring, Physiologic / Q000379:methods; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000276:immunology; D011184:Postoperative Period; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D007457:Iodine Radioisotopes; C047052:tumor-associated antigen 72