Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity.
The data reported suggest that--following initiation of lipid peroxidation--membrane protein thiols can be attacked by lipid-derived radicals and/or reactive, lipid-soluble aldehydes like 4-hydroxynonenal and other hydroxyalkenals originated within the lipid core of cell membranes, resulting in a membrane protein thiol loss which is in turn associated with the development of hepatocellular injury.
Pompella
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Istituto di Patologia Generale dell'Università di Siena, Italy.
Romani
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Benedetti
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Comporti
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D000433:1-Propanol / Q000633:toxicity; D000171:Acrolein / Q000633:toxicity; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D020005:Propanols; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D008054:Lipid Peroxides; D008565:Membrane Proteins; D020005:Propanols; D013438:Sulfhydryl Compounds; C006463:allyl alcohol; D000171:Acrolein; D000433:1-Propanol; D005978:Glutathione