The protective activity of tea against infection by Vibrio cholerae O1.
Extracts of black tea exhibited bactericidal activity against Vibrio cholerae O1. The tea extract inhibited the haemolysin activity of V. cholerae O1, El Tor and the morphological changes of Chinese hamster ovary cells induced by cholera toxin. Tea extract also reduced fluid accumulation induced by cholera toxin in sealed adult mice and by V. cholerae O1 in ligated intestinal loops of rabbits. These findings suggest that tea has protective activity against V. cholerae O1.
Toda
M
M
Department of Bacteriology and Immunology, Showa University School of Medicine, Tokyo, Japan.
Okubo
S
S
Ikigai
H
H
Suzuki
T
T
Suzuki
Y
Y
Shimamura
T
T
D000818:Animals; D002460:Cell Line; D002771:Cholera / Q000517:prevention & control*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D006460:Hemolysin Proteins / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D013662:Tea; D014734:Vibrio cholerae / Q000187:drug effects*
D006460:Hemolysin Proteins; D010936:Plant Extracts; D013662:Tea; D002772:Cholera Toxin