title: Application of the murine anti-Gd-2 antibody 14.Gd-2a for diagnosis and therapy of neuroblastoma.
abstract: We have tested the sialoganglioside monoclonal antibody Gd-2a for scintigraphic diagnostic and for immunotherapy in children with neuroblastoma stage IV. We could confirm tumor sites with Gd-2a scans in 1/2 children. Doses of 20-60 mg/m2 were administered daily for 5-10 days. 2/2 children with multiple tumor sites showed significant tumor regression. Four children, treated preventively, are still in clinical remission. One child showed tumor progression despite Gd-2a treatment. Adverse effects included itching, rashes, and pain.
authors.affiliation: Department of Nuclear Medicine, University of Tübingen, F.R.G.
authors.forename: P
authors.initials: P
authors.lastname: Reuland
authors.forename: R
authors.initials: R
authors.lastname: Handgretinger
authors.forename: H
authors.initials: H
authors.lastname: Smykowsky
authors.forename: R
authors.initials: R
authors.lastname: Dopfer
authors.forename: T
authors.initials: T
authors.lastname: Klingebiel
authors.forename: B M
authors.initials: BM
authors.lastname: Miller
authors.forename: R A
authors.initials: RA
authors.lastname: Reisfeld
authors.forename: S
authors.initials: S
authors.lastname: Gallagher
authors.forename: E
authors.initials: E
authors.lastname: Koscelniak
authors.forename: J
authors.initials: J
authors.lastname: Treuner
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging* / Q000276:immunology*; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal; D005732:Gangliosides; D007457:Iodine Radioisotopes