title: Value of technetium Mibi to detect short lasting episodes of severe myocardial ischaemia and to estimate the area at risk during coronary angioplasty.
abstract: 201Tl has been used for more than a decade in cardiology in spite of its physical properties, which are far from ideal. Other agents, with better physical characteristics, are desirable. Tc99m Mibi has become available. It is different from 201Tl not only because of a better energy, 140 (keV), shorter half-life (6 h), but also because it shows minimal redistribution; it can therefore be administered in a different location from where the nuclear investigation can be performed. In this study, we investigated the value of Tc99m Mibi to detect short-lasting episodes of ischaemia and to determine the area at risk during PTCA, by injecting the substrate in the catheterization laboratory during the first balloon inflation. The 13 patients studied, had single vessel disease, a normal resting ECG and a normal left ventricular contraction pattern. In eight, a PTCA was performed in the LAD, in three, in the circumflex, and in two, in the RCA. In 11 patients, a defect was seen in the single photon emission computer tomography images, which corresponds to the area supplied by the coronary artery, where flow was obstructed during PTCA. Tc99m Mibi is able to detect short-lasting episodes of ischaemia caused by a complete occlusion of the coronary artery. It is also of help to estimate the area at risk during PTCA.
authors.affiliation: Department of Cardiology, Academic Hospital Maastricht, State University of Limburg, The Netherlands.
authors.forename: S H
authors.initials: SH
authors.lastname: Braat
authors.forename: H
authors.initials: H
authors.lastname: de Swart
authors.forename: P
authors.initials: P
authors.lastname: Rigo
authors.forename: L
authors.initials: L
authors.lastname: Koppejan
authors.forename: G A
authors.initials: GA
authors.lastname: Heidendal
authors.forename: H J
authors.initials: HJ
authors.lastname: Wellens
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D006328:Cardiac Catheterization; D003287:Contrast Media; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi