Interleukin-1 beta release from human peripheral blood monocytes associated with phagocytosis of carbonyl-iron or erythrocytes.
Interleukin-1 beta (IL-1 beta) release from human peripheral blood monocytes during the incubation with carbonyl-iron or sheep red blood cells was investigated. The incubation of purified monocytes with carbonyl-iron or sheep red blood cells enhanced IL-1 beta release, while their compounds, hemoglobin, globin and ferric citrate did not. The mechanisms of IL-1 beta release by carbonyl-iron or sheep red blood cells may be related to their phagocytosis, as non-phagocytic monocytes did not release IL-1 beta.
Okamoto
M
M
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Sasano
M
M
Goto
M
M
Nishioka
K
K
Aotsuka
S
S
Nakamura
K
K
Yokohari
R
R
Miyamoto
T
T
D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D054354:Iron Carbonyl Compounds; D009000:Monocytes / Q000276:immunology*; D009942:Organometallic Compounds / Q000276:immunology; D010587:Phagocytosis
D007375:Interleukin-1; D009942:Organometallic Compounds; D054354:Iron Carbonyl Compounds