title: Heparin-induced thrombocytopenia and thrombosis: reversal with streptokinase. A case report and review of literature.
abstract: Heparin-induced thrombocytopenia and thrombosis is associated with a significant incidence of morbidity and mortality. Prompt recognition of this complication and immediate withdrawal of heparin therapy are imperative. This report describes a case of heparin-induced thrombosis and thrombocytopenia with major vascular insufficiency of the extremities. This is the first reported instance of the use of intravenous streptokinase for the treatment of heparin-induced venous thrombosis.
authors.affiliation: Department of Internal Medicine, Grace Hospital, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: D P
authors.initials: DP
authors.lastname: Mehta
authors.forename: E L
authors.initials: EL
authors.lastname: Yoder
authors.forename: J
authors.initials: J
authors.lastname: Appel
authors.forename: K L
authors.initials: KL
authors.lastname: Bergsman
mesh_terms: D000368:Aged; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy / Q000401:mortality; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000188:drug therapy / Q000401:mortality
chemical_list: D006493:Heparin; D013300:Streptokinase