title: Subpial beta/A4 amyloid deposition occurs between astroglial processes in Alzheimer-type dementia.
abstract: We examined the ultrastructure of subpial beta/A4 amyloid deposits in the brains of patients with Alzheimer-type dementia. A few amyloid fibrils were found between thick astroglial processes (glia limitans). We also examined the ultrastructural localization of beta/A4 protein by the indirect immunoperoxidase technique. Electron-dense immunoreactive products scattered sporadically in the subpial areas were observed between astroglial processes. The labeling was fibrillar and/or amorphous. Subpial beta/A4 deposition may occur between astroglial processes as amorphous pre-amyloid and amyloid fibrils.
authors.affiliation: College of Medical Care and Technology, Gunma University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazato
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: S
authors.initials: S
authors.lastname: Hirai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism* / Q000648:ultrastructure; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D016253:Microscopy, Immunoelectron
chemical_list: D016229:Amyloid beta-Peptides