Evaluation of the anticancer activities of Tweens 20, 40 and 60 in SJL/J mice.
Tween 20 (polyoxyethylenesorbitan monolaurate), Tween 40 (polyoxyethylenesorbitan monopalmitate), and Tween 60 (polyoxyethylenesorbitan monostearate) were found to have little activity against development of reticulum cell sarcoma in SJL/J mice. These findings resulted in studies to explain the previous observation that Tween 80 (polyoxyethylenesorbitan monooleate) has anticancer activity in the SJL/J tumor system. Evidence is presented to suggest that the apparent difference may be related to the fatty acid component (saturated or unsaturated) of the Tween.
Crispens
C G
CG
Department of Biology, University of Alabama, Birmingham 35294.
Sorenson
J R
JR
D000818:Animals; D000970:Antineoplastic Agents; D005260:Female; D016403:Lymphoma, Large B-Cell, Diffuse / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D011136:Polysorbates / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D011136:Polysorbates; C068430:polysorbate 40