title: Follow-up of spina bifida children with and without upper renal tract changes at birth.
abstract: The aim of this study was to assess 2 groups of children with spina bifida; one with and the other without upper renal tract (URT) changes at birth and to evaluate the outcome of their management. In Group 1, there were 148 patients who had normal URT at birth. They were studied for a mean follow-up of 131 months. Twenty-eight per cent developed URT changes in later life. The median time interval for URT changes to develop between birth and the first assessment which showed abnormal finding, was 33 months and between the last normal URT assessment and the development of URT changes, was 16 months. Six patients with URT changes were treated conservatively and 36 required intervention. Twenty-eight of 42 patients showed initial improvement of URT changes but 25 subsequently deteriorated. In 3 patients renal function deteriorated with renal failure in one and renal impairment in 2. In Group 2, 24 patients who had URT changes present at birth were also studied for a mean follow-up of 115 months. The URT changes in 8 patients deteriorated after the initial assessment over a median time of 15 months. Twelve patients' URT changes improved spontaneously without active intervention over a median time interval of 16 months but 5 subsequently deteriorated. Overall, the prognosis of children with URT changes at birth did not seem to be any worse than children developing changes later in life. Lesions of sacral and thoraco-lumbar regions of the spine were most commonly associated with URT changes.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow, Scotland.
authors.forename: J D
authors.initials: JD
authors.lastname: Greig
authors.forename: D G
authors.initials: DG
authors.lastname: Young
authors.forename: A F
authors.initials: AF
authors.lastname: Azmy
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D016135:Spinal Dysraphism / Q000145:classification / Q000503:physiopathology*; D014570:Urologic Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy