[Vasculotropin: a new angiogenic growth factor].
A new growth factor, provisionally named vasculotropin (VAS), with a unique specificity for vascular endothelial cells has been purified to homogeneity. VAS is a 45 kDa glycosylated homodimeric protein. Cloning of the VAS gene has evidenced a sequence homology with A and B chains of Platelet-Derived Growth Factor. The receptor on vascular endothelial cells has been shown to be a 180 kDa protein. A 110 kDa receptor has been found on cells that do not respond to the mitogenic effect of vasculotropin, such as lens epithelial cells or corneal endothelial cells.
Moukadiri
H
H
INSERM U.86, Centre des Cordeliers, Paris, France.
Favard
C
C
Praloran
V
V
Plouet
J
J
D006131:Growth Inhibitors / Q000502:physiology; D006133:Growth Substances / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D006131:Growth Inhibitors; D006133:Growth Substances; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors