title: t(11;14) (q13;q32) in B-cell lymphomas (intermediately differentiated lymphocytic and follicular). A report of four cases.
abstract: The association of recurrent chromosomal abnormalities with certain types of non-Hodgkin's lymphomas (NHLs) provides important clues to their classification and pathogenesis. The t(11;14), an uncommon abnormality, has been reported in a variety of B-cell lymphomas, including the intermediately differentiated lymphocytic lymphoma (IDLL). The authors report here the histologic, immunophenotypic, and cytogenetic findings in four additional patients with such translocation. They represent 8% of 51 patients with NHL studied by cytogenetics in a provincial hospital of Western mainland Japan. Three of the patients had IDLL and one a follicular lymphoma of large cell type. These findings strengthen the association between t(11;14) and IDLL. Furthermore, the occurrence of t(11;14) in a follicular lymphoma, as the sole abnormality, along with histogenetic considerations, suggests the possible existence of a rarer subset of follicular lymphoma, not associated with the t(14;18) and histogenetically related to IDLL.
authors.affiliation: Department of Hematopathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
authors.forename: G
authors.initials: G
authors.lastname: Frizzera
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Notohara
authors.forename: H
authors.initials: H
authors.lastname: Konishi
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics*