[Effects of oxygen radical scavengers on the output of 3-methylhistidine in urine after severe burns].
Burned rats (30% TBSA III) were divided into two groups at random: animals of group A receiving I. M. injection of bovine serum albumin served as control; group B, the treated group, received I.M. injection of superoxide dismutase (SOD) and catalase (CAT). The urine of these animals collected respectively on PBD 5,7,9,11, was analysed according to the improved program on the 121-MB Amino Acid Analyzer (Beckman) after acidolysis. It was found that on PBD 5,7,9,11 urinary 3-Mehis excretion was significantly lower in group B than that in group A (P less than 0.01). It suggested that probably a certain relationship existed between lipoperoxide and increased protein catabolism after severe burns. SOD and CAT, the oxygen radical scavengers could reduce protein catabolism to a certain extent.
Zhou
C G
CG
Central Lab, Third Military Medical College.
D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000652:urine*; D002374:Catalase / Q000627:therapeutic use; D016166:Free Radical Scavengers; D008297:Male; D008762:Methylhistidines / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D008762:Methylhistidines; D002374:Catalase; D013482:Superoxide Dismutase; C028118:3-methylhistidine