Lung lesions after combined inhalation of cobalt and nickel.
Rabbits inhaled 0.5 mg/m3 Co2+ as CoCl2, a combination of 0.5 mg/m3 Co2+ as CoCl2 and 0.5 mg/m3 of Ni2+ as NiCl2, or filtered air (controls) for 4 months, 5 days/week, 6 hr/day. The pattern of morphological effects on lung tissue and alveolar macrophages after the simultaneous exposure to Co2+ and Ni2+ was a combination of the patterns seen after exposure to Co2+ and Ni2+ alone. However, nickel seemed to potentiate the specific effect of cobalt, i.e., the formation of noduli of type II cells. Further, the increase in phospholipids, especially in 1,2-dipalmitoylphosphatidylcholine, appeared more pronounced after the combined exposure than after the additive combination.
Johansson
A
A
Section of Lung Medicine, Karolinska Institute, Stockholm, Sweden.
Curstedt
T
T
Camner
P
P
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003035:Cobalt / Q000008:administration & dosage / Q000633:toxicity*; D004357:Drug Synergism; D008168:Lung / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000008:administration & dosage / Q000633:toxicity*; D010743:Phospholipids / Q000032:analysis; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D011817:Rabbits
D000336:Aerosols; D010743:Phospholipids; D003035:Cobalt; D009532:Nickel