title: Respiratory patterns during sleep in mitochondrial myopathies with ophthalmoplegia.
abstract: Nocturnal polygraphic recordings (electroencephalography, electro-oculography, submental and intercostal muscle electromyography, electrocardiography, respiration by thoracic strain gauges and oronasal thermistors) with continuous monitoring of arterial oxyhemoglobin saturation by pulse oximeter were performed in 8 patients with ophthalmoplegia plus. All patients except 1 had normal blood gas values and normal lung volumes associated with a diminished ventilatory response to inhaled CO2 during wakefulness. Four patients showed pathological sleep-related breathing patterns consisting of sleep apneic polygraphic tracings mainly of the central type or of REM-related hypoventilation episodes. It is suggested that these disorders in patients with ophthalmoplegia plus may have a central origin and be related to the underlying metabolic disturbance.
authors.affiliation: Institute of Neurology, C. Mondino, University of Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Manni
authors.forename: G
authors.initials: G
authors.lastname: Piccolo
authors.forename: P
authors.initials: P
authors.lastname: Banfi
authors.forename: I
authors.initials: I
authors.lastname: Cerveri
authors.forename: C
authors.initials: C
authors.lastname: Bruschi
authors.forename: C
authors.initials: C
authors.lastname: Zoia
authors.forename: A
authors.initials: A
authors.lastname: Tartara
mesh_terms: D000328:Adult; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology*; D009886:Ophthalmoplegia / Q000503:physiopathology*; D015656:Respiratory Mechanics; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*