[Prevention of septicemia caused by gastrointestinal tract organisms in patients with granulopenia. Comparison of three gastrointestinal tract decontamination treatments].
Three gastrointestinal tract decontamination regimens were tested in patients with granulopenia: vancomycin 250 mg, tobramycin 75 mg, and colistin 1 million international units (regimen A); vancomycin 125 mg, tobramycin 75 mg, and colistin 1 million IU (regimen B); and colistin 1 million IU (regimen C); nystatin was added to all three regimens. Effectiveness was evaluated by stool organism counts and blood cultures to detect bacterial translocation (passage of bacteria from the intestinal tract to the bloodstream). Regimen C proved insufficiently effective. Regimen A was found to be poorly tolerated by the digestive mucosa. Regimen B was the best treatment since the low dosage of vancomycin proved effective. Nystatin satisfactorily eliminated yeasts.
Ramounau-Pigot
A
A
Service des Maladies du Sang, Hôpital Lapeyronie, Montpellier, France.
Monnet
P
P
Boyer
G
G
Darbas
H
H
Donadio
D
D
D000380:Agranulocytosis / Q000150:complications*; D003091:Colistin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D009761:Nystatin / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D014031:Tobramycin / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use*
D009761:Nystatin; D014640:Vancomycin; D014031:Tobramycin; D003091:Colistin