title: Quantitative changes in T helper inducer (CD4+ CD45RA-), T suppressor inducer (CD4+ CD45RA+), T suppressor (CD8+ CD11b+), and T cytotoxic (CD8+ CD11b-) subsets in human immunodeficiency virus infection.
abstract: To determine changes in subsets of CD4 and CD8 in relation to HIV infection and progression to AIDS, we quantitated peripheral blood lymphocytes obtained from 17 heterosexual controls, 22 asymptomatic HIV-seronegative and 18 HIV-seropositive intravenous drug users. 50 patients with AIDS-related complex (ARC), and 9 patients with AIDS using an EPICS "C" flow cytometer by two-color analysis. Both T helper inducer (CD4+ CD45RA-) and suppressor inducer (CD4+ CD45RA+) lymphocytes were decreased significantly in patients with ARC or AIDS. In contrast, T cytotoxic (CD8+ CD11b-) cells were significantly increased and accompanied by a significant decrease in the T suppressor (CD8+ CD11b+) subset in patients with ARC or AIDS. These results suggest that both T helper inducer and T suppressor inducer subsets of the CD4+ population and the T suppressor subset of CD8+ are depleted after HIV infection, while the T cytotoxic subset of CD8+ was increased after HIV infection.
authors.affiliation: R.A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital Center, New York, New York 10019.
authors.forename: M M
authors.initials: MM
authors.lastname: Reddy
authors.forename: M H
authors.initials: MH
authors.lastname: Grieco
mesh_terms: D000386:AIDS-Related Complex / Q000097:blood / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology; D015703:Antigens, CD; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D015703:Antigens, CD