[Anti-A/B-IgM/G immune response to accidental A-O transfusion and to Toxocara canis infestation].
We have applied a sensitive and reproducible AB0-ELISA, in combination with a hemagglutination test, for the study of class- and subclass specific humoral immune response in the AB0 system upon challenge by the intravenous route (A-type blood in a 0-recipient) and by helminthic A and B blood group antigen (Toxocara canis). After accidental transfusion, peak booster concentrations of anti-A-IgG reached 411 micrograms per g total IgG, with IgG1 and IgG2 subclasses evenly distributed. With Toxocara canis immunity, anti-A/B-IgG rose to 244 and 382 micrograms/g IgG, nearly 100% over the mean value of 15 healthy blood donors; it is noteworthy that these IgG levels almost exclusively consisted of IgG1. Both observations suggest that unusual presentation of A antigen to host leads to a predominant if not exclusive IgG booster reaction.
Buchs
J P
JP
Hämatologisches Zentrallabor, Universität, Inselspital Bern.
Maillard
H
H
Nydegger
U
U
D000017:ABO Blood-Group System / Q000276:immunology*; D000909:Antibodies, Helminth / Q000302:isolation & purification; D001787:Blood Group Incompatibility / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D017707:Erythrocyte Transfusion; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007518:Isoantibodies / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D014120:Toxocariasis / Q000276:immunology*; D065227:Transfusion Reaction
D000017:ABO Blood-Group System; D000909:Antibodies, Helminth; D007075:Immunoglobulin M; D007518:Isoantibodies