A model for the identification of hormone pulses.
Several hormones are released into the blood in a pulsating manner, that is, in short bursts which cause a rapid increase in the circulating concentration. The concentration then declines due to excretion, chemical breakdown, and redistribution into other compartments. Based on a series of observations of the level of hormone in the blood, investigators desire to quantify characteristics of these pulses, that is, timing, amplitude and rate of decay. We describe a statistical model for hormone pulse data and introduce a new method for estimating the characteristics of the pulses.
Kushler
R H
RH
Department of Mathematical Sciences, Oakland University, Rochester, MI 48309.
Brown
M B
MB
D000465:Algorithms; D000818:Animals; D003627:Data Interpretation, Statistical; D005260:Female; D006728:Hormones / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008838:Microcomputers; D008954:Models, Biological; D015233:Models, Statistical; D012756:Sheep; D012984:Software
D006728:Hormones; D007986:Luteinizing Hormone