title: Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
abstract: Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized with use of novel chemistries developed by us recently. Some of these derivatives show anti-HIV-1 activity at a concentration level of 1 microM and low cell toxicity in vitro. The most active and least toxic compounds are derivatives of 2-(3-pyridyl)quinoline. The results of the quantitative structure-activity relationship analyses, including several classical, linear regression correlations and a Free-Wilson approach of de novo model, provide guidelines for the design of new active compounds of this class.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta 30303.
authors.forename: L
authors.initials: L
authors.lastname: Strekowski
authors.forename: J L
authors.initials: JL
authors.lastname: Mokrosz
authors.forename: V A
authors.initials: VA
authors.lastname: Honkan
authors.forename: A
authors.initials: A
authors.lastname: Czarny
authors.forename: M T
authors.initials: MT
authors.lastname: Cegla
authors.forename: R L
authors.initials: RL
authors.lastname: Wydra
authors.forename: S E
authors.initials: SE
authors.lastname: Patterson
authors.forename: R F
authors.initials: RF
authors.lastname: Schinazi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D015497:HIV-1 / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D011804:Quinolines