[A case of second-degree atrioventricular block caused by high dose cisplatin treatment].
A 56-year-old man was admitted to our hospital because of stage IV squamous cell carcinoma of the lung. He was treated with two courses of high dose cisplatin (40 mg/m2/day, day 1-5). On day 4 of each course, a second-degree atrioventricular block was observed, which disappeared after cisplatin treatment. This case suggests that, although the cardiotoxicity caused by cisplatin is believed to be rare, one should take special care in high dose usage.
Tasaka
T
T
First Department of Internal Medicine, Kagawa Medical School, Japan.
Fujita
J
J
Futami
H
H
Yamaji
Y
Y
Hata
Y
Y
Bungo
M
M
Nakamura
H
H
Shiotani
T
T
Irino
S
S
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D002945:Cisplatin