title: Effect of cardiac denervation on cardiorespiratory responses to exercise in goats.
abstract: The purpose of this study was to determine whether intact cardiac innervation and a normal cardiovascular (CV) response are required for a normal ventilatory (VE) response to mild and moderate treadmill exercise in awake goats. Accordingly, we measured CV and respiratory responses to two levels of exercise in seven normal (N) and six cardiac-denervated (CD) goats. Evidence of surgical CD included 1) absence of a cardiac response during surgery when the left thoracic cardiac nerves, thoracic vagi, and right and left stellate ganglia were electrically stimulated, 2) total and 80% attenuation of baroreflex changes in heart rate (HR) when arterial blood pressure was raised or lowered, respectively, by infusion of vasoactive agents in awake goats, and 3) attenuation of the CV responses to exercise. At each level of exercise in the CD goats, the HR response was significantly reduced relative to the response observed before CD (P less than 0.05) and the recovery HR response was delayed. Cardiac index increased in a work rate-dependent manner in N and CD goats but was significantly lower in the CD animals (P less than 0.05). Hypotension was consistently observed during exercise following CD. There was no effect of CD on steady-state VE at any metabolic rate or on the VE-O2 uptake relationship (P greater than 0.05). The rest-to-work and work-to-work transition responses of arterial PCO2 were similar between N and CD goats, but there was a tendency toward greater hypocapnia at the exercise onset in CD goats at the highest work rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: A G
authors.initials: AG
authors.lastname: Brice
authors.forename: H V
authors.initials: HV
authors.lastname: Forster
authors.forename: L G
authors.initials: LG
authors.lastname: Pan
authors.forename: D R
authors.initials: DR
authors.lastname: Brown
authors.forename: A L
authors.initials: AL
authors.lastname: Forster
authors.forename: T F
authors.initials: TF
authors.lastname: Lowry
mesh_terms: D000818:Animals; D003714:Denervation; D005260:Female; D006041:Goats; D006321:Heart / Q000294:innervation* / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*