title: Role of neurotensin in radiation-induced hypothermia in rats.
abstract: The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.
authors.affiliation: Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
authors.forename: S B
authors.initials: SB
authors.lastname: Kandasamy
authors.forename: W A
authors.initials: WA
authors.lastname: Hunt
authors.forename: A H
authors.initials: AH
authors.lastname: Harris
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000528:radiation effects*; D007036:Hypothermia, Induced; D007276:Injections, Intraventricular; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009496:Neurotensin