title: Comparative efficacy of short-term versus long-term cefoxitin prophylaxis against postoperative infection after radical hysterectomy: a prospective study.
abstract: We report the results of a randomized, double-blind comparison of short-term versus long-term cefoxitin prophylaxis against infections after radical abdominal hysterectomy with pelvic and para-aortic lymphadenectomy. Of 113 evaluable patients, 54 (47.8%) received short-term (three doses) and 59 (52.2%) long-term (12 doses) prophylaxis with intravenous cefoxitin (2 g per dose). No significant differences in demographics, preoperative risk factors, or clinical course were detected between the two groups; nor did we detect significant differences in the incidence of surgical-site-related infections (7.4 versus 5.1%, respectively, P = .61), postoperative urinary tract infection, or other febrile morbidity. We conclude that short-term and long-term cefoxitin prophylaxis are equally effective for the prevention of post-operative surgical-site-related infections after radical hysterectomy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida.
authors.forename: B U
authors.initials: BU
authors.lastname: Sevin
authors.forename: R
authors.initials: R
authors.lastname: Ramos
authors.forename: R T
authors.initials: RT
authors.lastname: Gerhardt
authors.forename: L
authors.initials: L
authors.lastname: Guerra
authors.forename: S
authors.initials: S
authors.lastname: Hilsenbeck
authors.forename: H E
authors.initials: HE
authors.lastname: Averette
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002440:Cefoxitin / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000601:surgery*
chemical_list: D002440:Cefoxitin