[Physiological model of sulbactam pharmacokinetics in rats and humans. Distribution of sulbactam in the tissues after intravenous and intramuscular administration].
A 10-compartment physiological model of sulbactam pharmacokinetics is described. The model provides simulation of the pharmacokinetic profiles of the drug observed after its intra-muscular and intravenous administration in rats and humans. The adequate description of the drug distribution in human blood suggested that the model was applicable in designing rational schemes of sulbactam use.
Manuĭlov
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D000818:Animals; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D013407:Sulbactam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014781:Viscera / Q000378:metabolism*
D013407:Sulbactam