[Procoagulant and proteolytic activities of leukocytes in the foci of acute abscesses and gangrene of the lungs].
Essential role in development of acute purulent destruction of the lungs in attributed to proteinases of polimorphonuclear leukocytes. Poor localization of the destruction focus seems to result from low procoagulant activity of pulmonary macrophages. If the activity of purulent and destructive process stands high the ability of phagocytes to synthesize and release proteinases is realized fully. epsilon-Aminocaproic acid prohibits phagocytic proteolytic activity from growing under the influence of stimulators. Correction of defective leukocytic proteolysis and mononuclear activity can be done with prodigiozan, streptokinase and epsilon-aminocaproic acid.
Shoĭkhet
Ia N
IaN
Zaremba
S V
SV
Dukov
L G
LG
Roshchev
I P
IP
Shuster
L V
LV
D000208:Acute Disease; D001777:Blood Coagulation / Q000502:physiology*; D010450:Endopeptidases / Q000097:blood*; D005734:Gangrene; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology*; D008169:Lung Abscess / Q000097:blood* / Q000201:enzymology; D009000:Monocytes / Q000201:enzymology / Q000502:physiology*; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*
D010450:Endopeptidases