title: Effects of R51163 on intake and metabolism in moose.
abstract: R51163, a newly synthesized purine alkyl piperidine that produces reliable sedation in cattle, was tested in five adult bull moose (Alces alces). Compared with controls, all animals dosed with 0.4 mg/kg BW ate significantly (P less than 0.05) less dry matter for at least 1 wk after treatment. Median estimates of resting metabolism, measured the day of injection, did not differ between treatment and control groups, although the coefficient of variation was almost two times larger for drugged (15%) versus control (8%) individuals. Dose response was allometric, with larger animals exhibiting longer effects.
authors.affiliation: Alaska Department of Fish and Game, Moose Research Center, Soldotna 99669.
authors.forename: C C
authors.initials: CC
authors.lastname: Schwartz
authors.forename: K J
authors.initials: KJ
authors.lastname: Hundertmark
authors.forename: W R
authors.initials: WR
authors.lastname: Lance
mesh_terms: D000818:Animals; D003670:Deer; D004435:Eating / Q000187:drug effects*; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D012044:Regression Analysis; D014149:Tranquilizing Agents
chemical_list: D010880:Piperidines; D014149:Tranquilizing Agents; C050489:R 51163