title: Relationship of oscillatory potential amplitude to A-wave slope over a range of flash luminances in normal subjects.
abstract: The effect of flash luminance on the relationship of oscillatory potential (OP) amplitude, as a measurement of inner retinal function, to a-wave slope, as a measurement of photoreceptor function, was evaluated in full-field electroretinograms recorded from normal subjects. The ratio of OP amplitude to a-wave slope was found to be independent of flash luminance over a 3000-fold luminance range. This finding raises the possibility that a reduction in the ratio of OP amplitude to a-wave slope in eyes with media opacities may be used as a sign of inner retinal malfunction. Selected cases are presented to illustrate application of this approach.
authors.affiliation: Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston.
authors.forename: M A
authors.initials: MA
authors.lastname: Sandberg
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: G P
authors.initials: GP
authors.lastname: Matthews
authors.forename: A R
authors.initials: AR
authors.lastname: Gaudio
mesh_terms: D000328:Adult; D000368:Aged; D004596:Electroretinography; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000503:physiopathology*; D012044:Regression Analysis; D012160:Retina / Q000503:physiopathology*; D012170:Retinal Vein Occlusion / Q000503:physiopathology*; D014823:Vitreous Hemorrhage / Q000503:physiopathology*