title: P-31 spectroscopy study of response of superficial human tumors to therapy.
abstract: Studies were performed to characterize phosphorus-31 magnetic resonance (MR) spectra obtained from 10 superficial human tumors outside the brain and to determine whether P-31 MR spectroscopy could allow detection of a response to therapy before a change in tumor size was measured. The ratio of phosphomonoester to adenosine triphosphate peak intensities (PME/ATP) was unusually large in all tumors studied. The average PME/ATP in lymphomas (1.8 +/- 0.5) was greater than in nonlymphoma cancers (1.1 +/- 0.15). The average PME/ATP for all tumors studied (1.4 +/- 0.5) was much greater than that of underlying skeletal muscle (0.23 +/- .09). Eight of the tumors were studied before and after therapy. Responders were distinguished from nonresponders on the basis of changes in tumor size. PME/ATP decreased during therapy in three lymphomas that responded to therapy. In an adenocarcinoma and Ewing sarcoma that did not respond to therapy, PME/ATP increased. PME/ATP remained constant in two squamous cell carcinomas that responded to therapy and decreased in one squamous cell carcinoma that decreased in size by 40% but was classified as a nonresponder. Changes in PME/ATP did not always parallel changes in tumor size during therapy. In two patients, a decrease in PME/ATP preceded a decrease in tumor size. In four patients, PME/ATP increased transiently during periods when tumor size remained constant.
authors.affiliation: Magnetic Resonance Unit, Veterans Administration Medical Center, San Francisco.
authors.forename: G S
authors.initials: GS
authors.lastname: Karczmar
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyerhoff
authors.forename: M D
authors.initials: MD
authors.lastname: Boska
authors.forename: B
authors.initials: B
authors.lastname: Hubesch
authors.forename: J
authors.initials: J
authors.lastname: Poole
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: F
authors.initials: F
authors.lastname: Valone
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D001365:Axilla; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006119:Groin; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate