title: Anal tonometry in the neonatal period for the diagnosis of Hirschsprung's disease.
abstract: A double balloon technique was used for anal tonometry in 22 infants. The weight was less than 2,500 g in 10 of the infants. Ileus or delayed passage of meconium was seen in 9 infants. Thirteen infants had not revealed any symptoms of intestinal obstruction during the first week of life. In all cases, except one, it was possible to demonstrate reflexes from the internal anal sphincter. In 18 infants normal curves were registered from the internal anal sphincter. None of these developed Hirschsprung's disease. In 3 infants a pathological pattern of contractions of the internal anal sphincter was demonstrated. Two of them proved to have Hirschsprung's disease. In the third case normal reflexes were registered after one year. Possibly the innervation of rectum and the internal anal sphincter was disrupted during the neonatal period in connection with enterocolitis and ileus, thus representing a reversible case of achalasia.
authors.affiliation: Department of Neonatology and Paediatric Surgery, Rigshospitalet, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Verder
authors.forename: W
authors.initials: W
authors.lastname: Petersen
authors.forename: K
authors.initials: K
authors.lastname: Mauritzen
mesh_terms: D001003:Anal Canal / Q000502:physiology / Q000503:physiopathology*; D005260:Female; D006627:Hirschsprung Disease / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012018:Reflex / Q000502:physiology; D014065:Tonometry, Ocular