title: Melanocytic lesions and melanocyte populations in human epidermis.
abstract: Basal melanocytes were counted and atypia assessed on an arbitrary scale in punch biopsies from the sun-exposed extensor aspect of the forearm of normal skin and from the covered skin of the buttock of patients with pigmented naevi and control subjects. The difference in melanocyte counts and in the presence of atypia between sun-exposed and covered skin was statistically highly significant. The only other difference was between melanocyte counts in covered skin from those with multiple atypical naevi and all other groups; the counts in the former were greater than those in the latter. No further difference was attributable to sun exposure, skin type or diagnostic group. Some degree of melanocyte atypia was seen in approximately half of the biopsies of sun-exposed skin, but atypia was seen in only six of 84 biopsies of covered skin. In each case atypia was present in the corresponding forearm biopsy and all six subjects had pigmented lesions (four with melanoma and two with multiple atypical naevi). It seems possible that while increased melanocyte counts in covered skin could correlate with the presence of atypical naevi, atypia of covered epidermal melanocytes could possibly relate to melanoma risk.
authors.affiliation: Department of Histopathology, St George's Hospital, London, U.K.
authors.forename: M E
authors.initials: ME
authors.lastname: Fallowfield
authors.forename: R K
authors.initials: RK
authors.lastname: Curley
authors.forename: M G
authors.initials: MG
authors.lastname: Cook
mesh_terms: D000328:Adult; D000368:Aged; D002452:Cell Count; D004817:Epidermis / Q000473:pathology*; D005260:Female; D005542:Forearm; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000473:pathology; D009506:Nevus / Q000473:pathology; D010859:Pigmentation Disorders / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects