Pubertal growth and growth hormone secretion.
A dramatic increase in linear growth velocity, often referred to as the pubertal growth spurt, is a central feature of pubertal development. Despite the existence of numerous investigative attempts, a precise understanding of the hormonal events subserving this process has proved elusive. Nevertheless, evidence has gradually accumulated that indicates that sex steroid-induced modulation of growth hormone secretion is a central and critical feature of the pubertal growth spurt. As a result, disorders of either growth hormone or sex steroid hormone production may result in clinical growth disorders during puberty.
Martha
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Tufts University School of Medicine, Boston, Massachusetts.
Reiter
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D001827:Body Height; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006128:Growth; D013006:Growth Hormone / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008297:Male; D011627:Puberty / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone