title: [Intestinal T-cell lymphoma (so-called malignant histiocytosis of the intestine) complicated by multiple perforations].
abstract: We describe a case of intestinal T-cell lymphoma which was histologically diagnosed of malignant histiocytosis of the intestine. A 47-year-old man was admitted to our hospital because of fever and generalized lymphadenopathy. Mild anemia, leukocytosis, positive CRP and a high level of LDH were noted. Pathological finding of the lymph node was compatible with dermatopathic lymphadenopathy with a slight increase in atypical lymphoid cells. At the 14th day after admission, he suffered from abdominal pain and was diagnosed as having perforative peritonitis. In laparotomy, the infiltration of histiocyte-like atypical cells were found around a site of small perforation of the terminal ileum. The findings were compatible with that of malignant histiocytosis of the intestine (MHI). He had recurrent perforations of the small intestine and died of peritonitis and sepsis at the 42nd day. Southern blot analysis of the biopsied lymph node showed TCR-beta gene rearrangement. Some patients diagnosed clinically and pathologically as having MHI may have a T-cell lymphoma like our case.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University.
authors.forename: S
authors.initials: S
authors.lastname: Sadamura
authors.forename: T
authors.initials: T
authors.lastname: Chihara
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: J
authors.initials: J
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Nawata
authors.forename: M
authors.initials: M
authors.lastname: Nakagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D054747:Histiocytic Sarcoma / Q000150:complications*; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged