Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.
Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD). This response was reversible after the anesthetic gas was discontinued. Pretreatment with either alpha-adrenergic or beta-adrenergic antagonists (phentolamine or timolol) had no effect on the halothane-induced decrease in SCC. Delivery of the analgestic gas N2O did not alter baseline electrical measurements across the isolated I-CB.
Tang
L Q
LQ
Department of Ophthalmology, Northwestern University Medical School, Chicago, IL 60611.
Krupin
T
T
Milner
M
M
Woods
D
D
Miller
K
K
Carré
D A
DA
Civan
M M
MM
D000704:Analysis of Variance; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002924:Ciliary Body / Q000502:physiology*; D004737:Enflurane / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D007498:Iris / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D011817:Rabbits
D000777:Anesthetics; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane