[Inactivation of aminoglycosides by beta-lactams of the penicillin and cephalosporin groups].
Interaction of carbenicillin with kanamycin, gentamicin, tobramycin, and amikacin, as well as that of cefotaxime with the same aminoglycosides were studied. It was shown that carbenicillin inactivated aminoglycosides in a patient's plasma, urine, rH 5.3-8.44, and in buffer solutions, pH 3.7, 7.5 and 9.25. The inactivation level was the least in acid media. The mechanism of the inactivation was elucidated: opening of the carbenicillin beta-lactam ring occurred at the start.
Siniukhin
V N
VN
Nikolaeva
N P
NP
Rozynov
B V
BV
Darenkov
A F
AF
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors* / Q000097:blood / Q000652:urine; D002228:Carbenicillin / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002228:Carbenicillin; D002439:Cefotaxime