title: Acute cardiovascular effects of insulin in hyperglycaemic type I diabetics.
abstract: Cardiovascular responses to high-dose (0.100 IE kg-1 h-1) and low-dose insulin infusion (0.005-0.01 IE kg-1 h-1) were examined in eight hyperglycaemic, resting type I diabetics. Mean blood glucose dropped from 15.9 to 7.1 mmol l-1 and from 14.4 to 12.6 mmol l-1, respectively, during 1 h. Blood pressure and heart rate did not change. There were no significant changes in absolute or relative left ventricular volumes, the 95% confidence interval (CI) for the difference between the doses in left ventricular ejection fraction was -6 to 8%. Calf blood volume increased on high-dose insulin (p = 0.05, CI for the difference over low-dose insulin 0.0 to 4.6 ml 100 ml-1 tissue). Blood flow increased with 1.6 ml 100 ml-1 tissue min-1 with high-dose insulin and with 0.6 ml 100 ml-1 tissue min-1 with low-dose (CI for the difference -0.5 to 3.4). Noradrenaline increases were small and there was no difference between the doses (p = 0.47).
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Denmark.
authors.forename: P C
authors.initials: PC
authors.lastname: Gøtzsche
authors.forename: H
authors.initials: H
authors.lastname: Kelbaek
authors.forename: S F
authors.initials: SF
authors.lastname: Vissing
authors.forename: S L
authors.initials: SL
authors.lastname: Nielsen
authors.forename: O
authors.initials: O
authors.lastname: Munck
authors.forename: N J
authors.initials: NJ
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Lyngsøe
authors.forename: E R
authors.initials: ER
authors.lastname: Mathiesen
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin