Cyclic antidepressants and the risk of hip fracture.
To determine whether cyclic antidepressants increase the risk of hip fracture, we conducted a population-based case-control study in the Canadian province of Saskatchewan. We identified 4501 persons 65 years of age or older with a first hospitalization for hip fracture between 1977 and 1985 and 24,041 comparable controls. Current antidepressant users had a relative risk of hip fracture of 1.6 (95% confidence interval, 1.3 to 1.9). Medical record review for a sample of 164 cases suggested this finding was not due to confounding by body mass, impaired ambulation, functional status, or dementia.
Ray
W A
WA
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232-2637.
Griffin
M R
MR
Malcolm
E
E
D000058:Accidental Falls; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D016001:Confidence Intervals; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012525:Saskatchewan / Q000453:epidemiology
D000929:Antidepressive Agents, Tricyclic