Cytotoxic and aryl hydrocarbon hydroxylase-inducing effects of laboratory rodent diets. A cell culture study.
Extracts of several rodent diets were studied for their cytotoxic and aryl hydrocarbon hydroxylase-inducing properties by an in vitro method. The cell culture system based on a mouse hepatoma cell line (Hepa-1) was shown to be a convenient and sensitive method for screening of diets for these parameters implying the presence of compounds potentially harmful in vivo. Considerable differences among diets and batches were detected. Smallest effects were observed with a semipurified diet and with the unrefined diet which - contrary to other four unrefined diets - contained no fish.
Törrönen
R
R
Department of Physiology, University of Kuopio, Finland.
Kärenlampi
S
S
Pelkonen
K
K
D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002470:Cell Survival; D004032:Diet; D051379:Mice; D014407:Tumor Cells, Cultured / Q000201:enzymology*
D001189:Aryl Hydrocarbon Hydroxylases