title: Human placental low molecular weight factors inhibit the entry into cell cycle of murine pluripotent stem cells.
abstract: In 1977, Frindel et al. reported the presence in fetal calf bone marrow of a low molecular factor, the tetrapeptide Ac-N-Ser-Asp-Lys-Pro (AcSDKP), capable of inhibiting in vivo the hematopoietic pluripotent stem cell (CFU-S) recruitment into DNA synthesis and to increase the survival of mice which had received lethal doses of cytosine arabinoside (AraC), a phase-specific drug. Considering the potential clinical importance of CFU-S proliferation inhibitor during anticancer chemotherapy and the importance of monitoring the inhibitor by immunological methods, we tried to determine if a similar inhibitor is present in humans. Preliminary results indicate the presence in human placenta of an inhibitor coeluted with AcSDKP and which is effective in inhibiting murine CFU-S.
authors.affiliation: Inserm U.250, Institut Gustave-Roussy, Villejuif, France.
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: J
authors.initials: J
authors.lastname: Wdzieczak-Bakala
authors.forename: P
authors.initials: P
authors.lastname: Pradelles
authors.forename: E
authors.initials: E
authors.lastname: Frindel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D003561:Cytarabine / Q000494:pharmacology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006882:Hydroxyapatites; D007124:Immunoenzyme Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009842:Oligopeptides / Q000494:pharmacology / Q000502:physiology; D010920:Placenta / Q000737:chemistry*; D010924:Placental Extracts / Q000494:pharmacology* / Q000502:physiology
chemical_list: D006882:Hydroxyapatites; D009842:Oligopeptides; D010924:Placental Extracts; D003561:Cytarabine; C058504:goralatide