title: Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.
abstract: Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.
authors.affiliation: Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California 92037.
authors.forename: M I
authors.initials: MI
authors.lastname: Nerenberg
authors.forename: T
authors.initials: T
authors.lastname: Minor
authors.forename: J
authors.initials: J
authors.lastname: Price
authors.forename: D N
authors.initials: DN
authors.lastname: Ernst
authors.forename: T
authors.initials: T
authors.lastname: Shinohara
authors.forename: H
authors.initials: H
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D001483:Base Sequence; D015870:Gene Expression; D016355:Genes, pX; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013601:T-Lymphocytes / Q000382:microbiology*; D014170:Transformation, Genetic; D014407:Tumor Cells, Cultured