title: Use of technetium-99m(V)thiocyanate to measure gastric emptying of fat.
abstract: Technetium-99m(V)thiocyanate was evaluated as a radio-pharmaceutical for measuring gastric emptying of fat. Olive oil was labeled with 99mTc(V)thiocyanate by direct extraction from acidic thiocyanate solution. After incubation with dilute HCl (pH 1.4) at 37 degrees C for 3 hr, approximately 5% of the total radioactivity eluted into the aqueous phase. When incubated with human gastric juice (pH 1.8 and 2.2), approximately 8% of the activity was detected in the aqueous phase at 3 hr. Scintigraphic studies performed in two rabbits showed that olive oil labeled with 99mTc(V)thiocyanate emptied slowly from the stomach, with a gastric half-emptying time (T50) of more than 3 hr. A low-nutrient soup labeled with 113mIn-DTPA and mixed with 99mTc(V)thiocyanate labeled oil was consumed by six human volunteers. The oil emptied much more slowly (p less than 0.02) (median T50 = 198 min) than the aqueous component (median T50 = 30 min). These observations indicate that 99mTc(V)thiocyanate is a suitable pharmaceutical to measure gastric emptying of extracellular fat.
authors.affiliation: Department of Medicine, Royal Adelaide Hospital, South Australia.
authors.forename: K M
authors.initials: KM
authors.lastname: Cunningham
authors.forename: R J
authors.initials: RJ
authors.lastname: Baker
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.forename: A F
authors.initials: AF
authors.lastname: Maddox
authors.forename: M A
authors.initials: MA
authors.lastname: Edelbroek
authors.forename: B E
authors.initials: BE
authors.lastname: Chatterton
mesh_terms: D000328:Adult; D000818:Animals; D004041:Dietary Fats; D005746:Gastric Emptying; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D000069463:Olive Oil; D015609:Organotechnetium Compounds; D010938:Plant Oils; D011817:Rabbits; D013861:Thiocyanates
chemical_list: D004041:Dietary Fats; D000069463:Olive Oil; D015609:Organotechnetium Compounds; D010938:Plant Oils; D013861:Thiocyanates; C068692:technetium Tc 99m(V)thiocyanate