Transplacental distribution of atracurium, laudanosine and monoquaternary alcohol during elective caesarean section.
Maternal venous (MV), umbilical venous (UV) and umbilical arterial (UA) blood samples were obtained for assay of atracurium, laudanosine and monoquaternary alcohol concentrations in 22 healthy patients undergoing elective Caesarean section under general anaesthesia. At delivery (at a mean time of 8.2 min after atracurium 0.3 mg kg-1), the mean UV concentrations were 103 ng ml-1 (range 44-189 ng ml-1) for atracurium, 26 ng ml-1 (range 6-60 ng ml-1) for laudanosine and 59 ng ml-1 (range 21-148 ng ml-1) for monoquaternary alcohol. The ratios of UV:MV, UA:MV and UA:UV blood concentrations were related positively to time since injection of atracurium for all three substances (P less than 0.01 in each instance). The UV:MV ratio at delivery was greatest for laudanosine: mean 19.4% (range 1-35%), compared with 7% (range 2-21%) for atracurium and 10% (range 0-15%) for monoquaternary alcohol. These low values confirm that, although atracurium crosses the placental barrier and its metabolites may be found in the fetus, the drug is safe to use during Caesarean section.
Shearer
E S
ES
University Department of Anaesthesia, Royal Liverpool Hospital.
Fahy
L T
LT
O'Sullivan
E P
EP
Hunter
J M
JM
D000293:Adolescent; D000328:Adult; D000438:Alcohols / Q000097:blood; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D001279:Atracurium / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007546:Isoquinolines / Q000097:blood; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors; D014469:Umbilical Arteries; D014471:Umbilical Veins
D000438:Alcohols; D007546:Isoquinolines; D001279:Atracurium; C001522:laudanosine