title: Regional density of perfused capillaries and cerebral blood flow in untreated short-term and long-term streptozotocin diabetes.
abstract: The regional density of perfused cerebral capillaries (rDPC) and regional cerebral blood flow (rCBF) were measured in 12 selected brain regions in rats after 3 and 20 weeks of streptozotocin-induced diabetes and in control groups. After 3 weeks of diabetes, both rCBF and rDPC were unchanged in the diabetic group compared to the control group. A diabetes duration of 20 weeks causing bilateral cataracts induced a significant (p less than 0.05) reduction in rCBF in two structures in the visual system compared to the control group (visual cortex: 105 versus 129 ml 100 g-1 min-1; lateral geniculate body: 106 versus 128 ml 100 g-1 min-1) and in the pontine reticular nucleus (82 versus 128 ml 100 g min-1), whereas rDPC remained unchanged. A highly significant correlation between rCBF and rDPC was found in both control groups (r = 0.8, p less than 0.005) whereas the correlation was more scattered in the diabetic groups (r = 0.6, p less than 0.05). The present results show that during chronic diabetes, a reduction of rCBF does not affect the number of perfused capillaries.
authors.affiliation: Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
authors.forename: G M
authors.initials: GM
authors.lastname: Knudsen
authors.forename: U
authors.initials: U
authors.lastname: Göbel
authors.forename: O B
authors.initials: OB
authors.lastname: Paulson
authors.forename: W
authors.initials: W
authors.lastname: Kuschinsky
mesh_terms: D000818:Animals; D002196:Capillaries / Q000473:pathology*; D002386:Cataract / Q000209:etiology; D002560:Cerebrovascular Circulation; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D005829:Geniculate Bodies / Q000098:blood supply; D008297:Male; D011149:Pons / Q000098:blood supply; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014793:Visual Cortex / Q000098:blood supply