Oxygen free radicals and Parkinson's disease.
The involvement of oxygen radicals in the pathogenesis of Parkinson's disease has been suggested for some time. This article reviews the evidence supporting the involvement of oxygen radicals in the disease process in the brain. This includes a discussion of iron, lipid peroxidation, peroxidase, catalase, superoxide dismutase, and glutathione levels in the brain. In addition, various theories of induction of Parkinson's disease are discussed in relation to the possible involvement of oxygen radicals. These theories include the environmental toxin theory, the dopamine turnover theory, and the cerebral blood flow theory.
Adams
J D
JD
School of Pharmacy, University of Southern California, Los Angeles 90033.
Odunze
I N
IN
D001921:Brain / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D010100:Oxygen / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D010100:Oxygen; D004298:Dopamine