Nucleotide sequence of the murine prothymosin alpha cDNA and its deduced primary and secondary protein structure.
Searching for proliferation-related and cell cycle phase-specific genes we detected a full-length cDNA for the murine prothymosin alpha mRNA which was sequenced on the DNA level. The amino acid sequence deduced from the nucleotide sequence shows a high degree of positional identities with prothymosin alpha from man and rat. However, the minor differences in the primary structures largely influence predictions for the secondary structures of prothymosin alpha from different species. These differences in the secondary structure could explain the differences of activity of prothymosin alpha from different origin in immuno-protection assays.
Schmidt
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Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg, F.R.G.
Werner
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D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013947:Thymosin / Q000031:analogs & derivatives* / Q000235:genetics
D011498:Protein Precursors; D012333:RNA, Messenger; C040782:prothymosin alpha; D013947:Thymosin; D004247:DNA