title: Naproxen-associated duodenal ulcer complicated by perforation and bacteria- and barium sulfate-induced peritonitis in a dog.
abstract: Signs of abdominal pain and frequent vomiting developed in a 4-year-old dog that had been given naproxen sodium for 3 weeks. The examination included an upper gastrointestinal contrast study, using barium sulfate (BaSO4). Nine hours after barium administration, a duodenal ulcer perforated, leaking duodenal contents and BaSO4 into the peritoneal cavity. The ulcer was surgically resected, and the BaSO4 was manually removed, using saline solution-soaked gauze sponges. Treatment included peritoneal drainage and lavage every 6 hours. Recovery was without complications and the dog has not had any detectable long-term effects from peritonitis induced by BaSO4.
authors.affiliation: Veterinary Emergency Service, Inc, Fresno, CA 93703.
authors.forename: R W
authors.initials: RW
authors.lastname: Gfeller
authors.forename: A D
authors.initials: AD
authors.lastname: Sandors
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000009:adverse effects; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D010439:Peptic Ulcer Perforation / Q000150:complications / Q000662:veterinary*; D010538:Peritonitis / Q000139:chemically induced / Q000209:etiology / Q000662:veterinary*
chemical_list: D001466:Barium Sulfate; D009288:Naproxen