Genotoxic effects of dithane M-45 on the bone marrow cells of mice in vivo.
Genotoxic effects of dithane M-45 were studied on the bone marrow cells of male albino mice (Lacca strain) in vivo. Different doses (30 mg, 40 mg and 300 mg/kg b.wt) of dithane M-45 were injected intraperitoneally and their effects were investigated after time intervals of 1, 2, 5 and 10 days. The chromosomal aberrations observed in the bone marrow cells of male mice after treatment with dithane M-45 were fragments, rings, dicentric chromosomes, terminal chromatid deletions, chromatid gaps and breaks. In addition to these chromosomal aberrations, physiological effects such as uneven stretching of chromatin material, end-to-end chromosomal associations, exchange configurations, clumping, stickiness and centromeric associations were also observed.
Gautam
D C
DC
Department of Biosciences, Himachal Pradesh University, Shimla, India.
Kapoor
L
L
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002843:Chromatin / Q000187:drug effects; D002869:Chromosome Aberrations; D007621:Karyotyping; D008297:Male; D008344:Maneb / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D015038:Zineb / Q000031:analogs & derivatives* / Q000633:toxicity
D002843:Chromatin; D009153:Mutagens; D008344:Maneb; C011453:dithane M-45; D015038:Zineb