title: Leaflet geometry and function in porcine bioprostheses.
abstract: The leaflet geometry and hydrodynamic function of five porcine bioprostheses have been studied and compared to a fresh tissue porcine valve. The neutral leaflet geometries in two high pressure fixed valves (Carpentier Edwards and Hancock) and two low pressure fixed valves (Carpentier Edwards Supra-Annular and Hancock 2) had been modified during fixation and mounting. The leaflets were extended or displaced downwards towards the base of the valve, producing a higher ratio of circumferential leaflet length to inter-commissural spacing than in the fresh tissue valve. This produced high bending strains in the commissural area of the open leaflet in hydrodynamic tests. The leaflet geometry of the fresh tissue porcine valve studied was defined by a cylindrical shell inclined at approximately 27 degrees to the base of the valve and showed reduced open leaflet bending strains. Leaflet opening at low flows was dependent on leaflet geometry. Geometrical changes which are induced during mounting and fixation produced higher bending strains in the commissural area of the open leaflets. These may be contributing factors to tissue degeneration and calcification in this area.
authors.affiliation: Cardiac Research Unit, Killingbeck Hospital, Leeds, UK.
authors.forename: M
authors.initials: M
authors.lastname: Butterfield
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: G A
authors.initials: GA
authors.lastname: Davies
authors.forename: J M
authors.initials: JM
authors.lastname: Kearney
mesh_terms: D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011673:Pulsatile Flow; D013329:Structure-Activity Relationship