title: Histopathological changes in sheep experimentally infected with Babesia ovis.
abstract: Histopathological study was made of 12 Merino sheep - five splenectomized and seven intact - experimentally infected with Babesia ovis. Non-purulent encephalitis; initially exudative and subsequently interstitial pneumonia; pericarditis, myocarditis and haemorrhagic endocarditis; centrilobular necrotic hepatitis; hyperplasia of the lymphoreticular system; necrosis and vascular changes in adrenal glands were observed. The kidney was the most severely affected organ, exhibiting acute tubular necrosis typical of kidney shock syndrome. The lesions observed were suggestive of hypovolemic shock culminating in haemorrhagic diathesis owing to consumptive coagulopathy. Additionally, the massive release of catabolites from lysis and necrosis apparently produced endotoxic shock.
authors.affiliation: Department of Animal Health and Medicine, Faculty of Veterinary Sciences, Cáceres, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Habela
authors.forename: D
authors.initials: D
authors.lastname: Reina
authors.forename: I
authors.initials: I
authors.lastname: Navarrete
authors.forename: E
authors.initials: E
authors.lastname: Redondo
authors.forename: S
authors.initials: S
authors.lastname: Hernández
mesh_terms: D000018:Abomasum / Q000473:pathology; D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001404:Babesiosis / Q000473:pathology*; D001921:Brain / Q000473:pathology; D005260:Female; D007422:Intestines / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013156:Splenectomy / Q000662:veterinary