Low level of prostacyclin as a risk of ischaemic heart disease.
We have studied the relationship between levels of lipids and prostacyclin in 3- to 14-year-old children with a family history of ischaemic heart disease. The total levels of cholesterol in the serum of these children increased, while levels of the HDL-fraction and prostacyclin (measured as 6-keto-prostaglandin F1a) decreased significantly. Levels of thromboxane B2 in the plasma were unchanged. It is suggested that, in childhood, abnormalities of lipid metabolism co-exist with decreased levels of prostacyclin. The latter may be a new important indicator of early atherosclerotic disease.
Petö
J
J
Department of Pathology, County Hospital, Kecskemét, Hungary.
Mihai
K
K
Makáry
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000293:Adolescent; D001161:Arteriosclerosis / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D013929:Thromboxane B2 / Q000097:blood
D008076:Cholesterol, HDL; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002784:Cholesterol