[The effect of irradiation on the development of streptozotocin diabetes in C57BL/KsJY mice heterozygous and homozygous for gene db (diabetes)].
In experiments with C57BL/KsJY mice carrying a mutant db gene at the heterozygous and homozygous states it has been found that db+/+db mice are much more sensitive to gamma radiation with respect to the survival rate. In homozygotes, in contrast to heterozygotes, irradiation with a dose of 6 Gy does not reduce the severity of the diabetogenic effect of low doses of streptozotocin.
Blokh
K O
KO
Blokh
O V
OV
Poltorak
V V
VV
Brindak
O I
OI
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000235:genetics / Q000401:mortality; D005720:Gamma Rays; D005808:Genes, Recessive / Q000235:genetics / Q000528:radiation effects*; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains / Q000235:genetics*; D011836:Radiation Tolerance; D014916:Whole-Body Irradiation