title: Acyclovir-induced renal failure: course and risk factors.
abstract: Of 19 children treated with high-dose intravenous acyclovir, 7, all of whom had encephalitis, also had a restricted fluid intake. Of these, 3 experienced non-oliguric renal insufficiency (plasma creatinine up to 176, 250 and 351 mumol/l, respectively) which resolved within 1 week of discontinuing acyclovir. Renal function was stable in the remaining 4 patients in this group and in the 12 children treated with acyclovir but without fluid restriction. We suggest the decreased renal function resulted from intratubular acyclovir crystalluria.
authors.affiliation: Department of Paediatrics, University Children's Hospital, Inselspital, Berne, Switzerland.
authors.forename: M G
authors.initials: MG
authors.lastname: Bianchetti
authors.forename: C
authors.initials: C
authors.lastname: Roduit
authors.forename: O H
authors.initials: OH
authors.lastname: Oetliker
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects*; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D000212:Acyclovir