[Endogenous factors in the pathogenesis of vulvar cancer].
In 59 patients with cancer of the vulva, levels of ACTH, FSH, thyrotropin, prolactin, somatotropin, cortisol, triiodothyronine, thyroxin, testosterone, progesterone and estradiol were measured in blood whereas those of 17-HOCS, 17-CS and estrogens--in urine. Hormonal imbalance was established at all levels of the endocrine system, viz. increased concentrations of cortisol and 17-HOCS, decreased ACTH level, shift in androgen/estrogen and androgen/progestin ratios towards testosterone, lowered FSH and somatotropin output and elevated blood-prolactin level.
Sidorenko
Iu S
IuS
Nerodo
G A
GA
Mar'ianovskaia
G Ia
GIa
Cherniavskaia
G Ia
GIa
Tiutiunova
A M
AM
D005260:Female; D006728:Hormones / Q000032:analysis; D006801:Humans; D009367:Neoplasm Staging; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D006728:Hormones