The association of age with aspirin esterase activity in human liver.
The activity of the phase 1 enzyme aspirin esterase was studied in liver tissue from 16 patients, aged 45-88 years. No correlation between age and enzyme activity was found in post-mitochondrial, cytosolic and microsomal fractions. These results provide further evidence that age is not a major determinant of the activity of hepatic drug-metabolizing enzymes in man.
Yelland
C
C
Department of Medicine (Geriatrics), The University, Newcastle upon Tyne.
Summerbell
J
J
Nicholson
E
E
Herd
B
B
Wynne
H
H
Woodhouse
K W
KW
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003600:Cytosol / Q000201:enzymology; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic / Q000502:physiology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D012016:Reference Values
D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase