title: [Perioperative preventive use of antibiotics in neurosurgery. Experience with a fixed antibiotic combination of mezlocillin and oxacillin (optocillin)].
abstract: We report a retrospective account of 200 patients who have been surveyed after having undergone neurosurgical intervention. They received as perioperative antibiotic prophylaxis a combination of Mezlocillin and Oxacillin in a ratio of 2:1 (Optocillin) in their management. The clinical and bacteriological efficacy including the side effects was examined with standardisation of sterility measures in the operating theatre, careful standardised operative procedures and ward after care. No problems in wound healing were found. There was no certain evidence of side effects.
authors.affiliation: Klinik und Poliklinik für Neurochirurgie, Westfälischen Wilhelms-Universität Münster.
authors.forename: R
authors.initials: R
authors.lastname: Mewe
authors.forename: H J
authors.initials: HJ
authors.lastname: König
authors.forename: H L
authors.initials: HL
authors.lastname: Karhoff
mesh_terms: D002493:Central Nervous System Diseases / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000008:administration & dosage*; D011292:Premedication; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: C024259:optocillin; D008802:Mezlocillin; D010068:Oxacillin