title: Arteriovenous shunting in patients with colorectal liver metastases.
abstract: The outlook for patients with colorectal liver metastases is poor. Microspheres have been combined with cytotoxics and administered via the hepatic artery in an attempt to improve tumour drug exposure within the liver. However, it has been suggested that arteriovenous connections might occur in association with intrahepatic tumours causing loss of regional advantage, and that the administration of microspheres further exacerbates arteriovenous shunting. In seven patients with colorectal liver metastases, base-line shunting was measured using a tracer quantity of radio-labelled albumin microspheres. The shunted fraction of a 'therapeutic quantity' of microspheres was subsequently measured in the same group of patients using albumin microspheres carrying a different radio-label. Base-line shunt for 0.5 x 10(6) microspheres was found to be 2.2 +/- 1.8% (mean +/- s.d.); the percentage shunt of a therapeutic quantity (40-80 x 10(6)) of microspheres was 3.0 +/- 0.8%. We conclude that arteriovenous shunting in patients with colorectal liver metastases is minimal, and is not significantly increased by the administration of therapeutic quantity of microspheres during regional chemotherapy.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Goldberg
authors.forename: J A
authors.initials: JA
authors.lastname: Thomson
authors.forename: G
authors.initials: G
authors.lastname: McCurrach
authors.forename: J H
authors.initials: JH
authors.lastname: Anderson
authors.forename: N
authors.initials: N
authors.lastname: Willmott
authors.forename: R G
authors.initials: RG
authors.lastname: Bessent
authors.forename: J H
authors.initials: JH
authors.lastname: McKillop
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000556:secondary; D008863:Microspheres
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes