title: Urethral blood circulation during cardiopulmonary bypass.
abstract: The haemodynamic changes induced by extracorporeal circulation (ECC) are thought to be important in the induction of urethral strictures in open heart surgery when indwelling latex catheters are used. In the present study, 6 piglets were cannulated and connected to extracorporeal perfusion apparatus. Pump flows correlated with human ECC values with non-haemic prime were used. The mucosal and submucosal blood circulation in the urethra reduced by 66% during ECC (P less than 0.05). The brain and hepatic arterial flows increased. A significant reduction was seen in renal blood circulation. The changes in the urethral blood circulation during ECC correlated with previous findings. The reduced wash out levels of chemicals leaching from the indwelling latex catheters as a result of reduced local blood circulation are the main trigger for the induction of urethral strictures during ECC and in other shock-like circulatory disturbances in the human body.
authors.affiliation: Department of Surgery, Päijät-Häme Central Hospital, Lahti, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Talja
authors.forename: A
authors.initials: A
authors.lastname: Lehtola
authors.forename: M
authors.initials: M
authors.lastname: Salmenperä
authors.forename: M
authors.initials: M
authors.lastname: Ruutu
authors.forename: S L
authors.initials: SL
authors.lastname: Karonen
authors.forename: O
authors.initials: O
authors.lastname: Alfthan
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002315:Cardiopulmonary Bypass; D002560:Cerebrovascular Circulation; D006499:Hepatic Artery; D008297:Male; D012039:Regional Blood Flow; D012079:Renal Circulation; D013552:Swine; D014521:Urethra / Q000098:blood supply*