[Proteolytic enzymes and antiproteases in eye tissue and blood serum. and the protein composition of aqueous humor in experimental corneal burns].
After deep termic and alkaline burns of rabbit's cornea the increasing of activity of neutral trypsinlike proteases, elastase and simultaneous increasing of antitryptic activity are observed in burned part of cornea, part of cornea which is surrounding the burn, and in ciliary body, iris and aqueous humor. One week after termic burn and two weeks after alkaline burn the means of these activities began decrease. The time, when ulceration and perforation of cornea are observed, is corresponded to the period of maximal activity of proteolytic enzymes in the eye tissues. At the peripherical blood there are significant changes of level of main inhibitors of proteolysis (reactants of acute phase of inflammation -alpha 1 antitrypsin and alpha 2 macroglobulin). There are qualitative and quantitative changes of proteins content of aqueous humour in the burned eyes, which have phase characteristics and depend upon the stage of inflammation process.
Jegorowa
E W
EW
Helmholtz-Forschungsinstitut für Augenkrankheiten Moskau.
Gundorowa
R A
RA
Tschesnokowa
N B
NB
Bordjugowa
G G
GG
Sosulina
N E
NE
D000818:Animals; D001082:Aqueous Humor / Q000201:enzymology*; D001813:Blood-Retinal Barrier / Q000502:physiology*; D002057:Burns, Chemical / Q000201:enzymology*; D003315:Cornea / Q000098:blood supply / Q000201:enzymology; D065306:Corneal Injuries; D010450:Endopeptidases / Q000378:metabolism*; D005126:Eye Burns / Q000139:chemically induced* / Q000201:enzymology; D005136:Eye Proteins / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism
D005136:Eye Proteins; D011480:Protease Inhibitors; D012709:Serum Albumin; D010450:Endopeptidases