Striatal calcitonin gene-related peptide-like immunoreactive afferents from the regions ventral and medial to the medial geniculate nucleus of rats.
The sources of fibers with immunoreactivity to calcitonin gene-related peptide in the caudal portion of the caudate-putamen were investigated in animals treated by a knife cut, a tracer injection, or an electrolytic lesion of regions ventral and medial to the medial geniculate nucleus. Hemitransection of the brain just caudal to the caudate-putamen decreased ipsilaterally calcitonin gene-related peptide-like immunoreactivity in the caudal portion of the caudate-putamen, suggesting that calcitonin gene-related peptide-like immunoreactive fibers in the caudate-putamen originated from neurons in the area caudal to the caudate-putamen. Some calcitonin gene-related peptide-like immunoreactive neurons in the regions ventral and medial to the medial geniculate nucleus, including the peripeduncular, posterior intralaminar and suprageniculate nuclei, were labeled ipsilaterally with a retrograde tracer after an injection into the caudal portion of the caudate-putamen. In addition, an electrolytic lesion of calcitonin gene-related peptide-like immunoreactive neurons in the regions ventral and medial to the medial geniculate nucleus decreased the number of calcitonin gene-related peptide-like immunoreactive fibers in the ipsilateral caudal portion of the caudate-putamen. These results suggest that some cells containing calcitonin gene-related peptide in several posterior thalamic nuclei project to the caudal caudate-putamen.
Kubota
Y
Y
Department of Anatomy, Osaka University Medical School, Japan.
Inagaki
S
S
Shimada
S
S
Takatsuji
K
K
Tohyama
M
M
Takagi
H
H
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism / Q000648:ultrastructure; D003342:Corpus Striatum / Q000378:metabolism*; D005829:Geniculate Bodies / Q000166:cytology / Q000378:metabolism*; D006735:Horseradish Peroxidase; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D014909:Wheat Germ Agglutinins
D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D015740:Calcitonin Gene-Related Peptide