Mononuclear cell infiltrate and HLA-Dr expression in intra- and extradural secondary carcinomas.
Frozen sections from 30 secondary carcinomas (22 intra- and 8 extradural) were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, NK cells and HLA-Dr invariant chain. A moderate number of macrophages was demonstrated in 91% of tumours. CD 8 and CD 4 lymphocytes were detected in smaller numbers in 68% and 28% of tumours respectively. B lymphocytes were present in only one tumour and NK cells were absent. There was no significant difference between the mononuclear cell infiltrate in the intra- and extradural tumours and in respect to the histological tumour type. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 5/22 (22%) (4 adeno and 1 anaplastic carcinoma; of which one adenocarcinoma was extradural and the remaining intradural). The results may represent evidence for a degree of cellular immune response to secondary carcinomas which is independent of the intra- or extradural location of the tumour.
Rossi
M L
ML
Dept. of Neuropathology, Radcliffe Infirmary, Oxford, Great Britain.
Jones
N R
NR
Esiri
M M
MM
Havas
L
L
al Izzi
M
M
Coakham
H B
HB
D000911:Antibodies, Monoclonal; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology* / Q000556:secondary; D002465:Cell Movement; D015174:Epidural Neoplasms / Q000276:immunology* / Q000473:pathology* / Q000556:secondary; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens