Influence of HIV antigens on functional activity of neutrophilic granulocytes in.
The effect of nine HIV antigens, including eight synthetic peptides, on the functional activity of granulocytes was studied using the reduction of nitroblue tetrazolium test (NBT test). Some peptides partly suppressed the functional activity of granulocytes. The most pronounced suppression was caused by ImVL (HIV-1 lysate immobilized on plates for ELISA) and SP-7 (a synthetic peptide from the gp41 protein of HIV-1). The degrees to which the functional activity of granulocytes was suppressed by ImVL and SP-7 was in inverse proportion to the specific antibody concentrations. No correlation was found between the reduction in the NBT test value and the amount of CD4+, CD8+ cells on CD4/8 ratio.
Gabrilovich
D I
DI
Laboratory of Epidemiology and Prevention of AIDS, USSR Ministry of Public Health, Moscow.
Kozhich
A T
AT
Suvorova
Z K
ZK
Ivanov
V S
VS
Moshnikov
S A
SA
Chikin
L D
LD
Kolezonkova
O V
OV
Pokrovsky
V V
VV
D000328:Adult; D005260:Female; D015488:HIV Antigens / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015488:HIV Antigens; D009580:Nitroblue Tetrazolium