title: Immunoscintigraphy of prostatic cancer: preliminary results with 111In-labeled monoclonal antibody 7E11-C5.3 (CYT-356).
abstract: A phase 1 study was conducted with the investigational immunoscintigraphic agent, 111In-CYT-356, a radiolabeled, site-specific immunoconjugate of monoclonal antibody 7E11-C5.3, in 40 patients with prostatic carcinoma and known distant metastases. Each patient received a single intravenous infusion of CYT-356 (dose range, 0.1-5 mg) radiolabeled with approximately 5 mCi of 111In. None of the patients experienced adverse reactions. One patient who received a 5-mg dose developed antibodies to the CYT-356 immunoconjugate. 111In-CYT-356 immunoscintigraphy detected bony metastases in 21 of 38 patients (55%), including 12 of 14 (86%) receiving concomitant hormonal therapy, and soft tissue lesions in four of six patients (67%). Antibody imaging detected occult lesions in the bony pelvis and lumbar spine, which were confirmed by follow-up imaging tests, in one patient. Higher CYT-356 doses may clear the blood pool more slowly. These results suggest that 111In-CYT-356 can be safely administered to patients with prostatic carcinoma and that further clinical investigation of this agent is warranted.
authors.affiliation: CYTOGEN Corporation, Princeton, New Jersey 08540.
authors.forename: G E
authors.initials: GE
authors.lastname: Wynant
authors.forename: G P
authors.initials: GP
authors.lastname: Murphy
authors.forename: J S
authors.initials: JS
authors.lastname: Horoszewicz
authors.forename: C E
authors.initials: CE
authors.lastname: Neal
authors.forename: B D
authors.initials: BD
authors.lastname: Collier
authors.forename: E
authors.initials: E
authors.lastname: Mitchell
authors.forename: G
authors.initials: G
authors.lastname: Purnell
authors.forename: I
authors.initials: I
authors.lastname: Tyson
authors.forename: A
authors.initials: A
authors.lastname: Heal
authors.forename: H
authors.initials: H
authors.lastname: Abdel-Nabi
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes