Late-onset globoid cell leukodystrophy mimicking an infiltrating glioma.
A 3 1/2 year old girl who developed a gradual left hemiparesis and hemianopia is reported. Neuroimaging studies demonstrated an infiltrating-like high density lesion which crossed the splenium of the corpus callosum, thought to represent a glioma. Subsequent brain biopsy established the correct diagnosis of globoid cell leukodystrophy (GCL), which suggests that the radiographic appearance of late-onset GCL may mimic that of an infiltrating glioma.
Epstein
M A
MA
Department of Neurology, Children's Hospital, University of Pennsylvania School of Medicine, Philadelphia.
Zimmerman
R A
RA
Rorke
L B
LB
Sladky
J T
JT
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D007965:Leukodystrophy, Globoid Cell / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed