title: Effects of dietary alteration on trimethylaminuria as measured by mass spectrometry.
abstract: The urine of a 9-year-old boy suffering from extreme body odour was assayed for trimethylamine (TMA) by gas chromatography-mass spectrometry. A trapping column bed, specifically designed for volatile compounds, was used in the mass spectrometry. The diagnosis of rare trimethylaminuria was confirmed by the presence of appreciable urinary TMA. Urinary TMA concentrations were reduced to virtually nil after the elimination of the major choline sources (fish and eggs) from the diet.
authors.affiliation: Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis 95616-8654.
authors.forename: M A
authors.initials: MA
authors.lastname: Hollinger
authors.forename: B
authors.initials: B
authors.lastname: Sheikholislam
mesh_terms: D000818:Animals; D002648:Child; D002794:Choline; D004032:Diet; D004531:Eggs; D005399:Fishes; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008460:Meat; D008661:Metabolism, Inborn Errors / Q000652:urine; D008744:Methylamines / Q000652:urine*; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000172:deficiency*; D009812:Odorants
chemical_list: D008744:Methylamines; D006899:Mixed Function Oxygenases; C023336:trimethylamine; D002794:Choline