title: On the mechanisms of ventricular tachycardia acceleration during programmed electrical stimulation.
abstract: BACKGROUND
  The pathophysiological mechanisms leading to acceleration of ventricular tachycardia (VT) are still unclear.
  
  
  RESULTS
  High-resolution epicardial mapping was used to study the mechanisms of VT acceleration by programmed electrical stimulation (PES) in a model of sustained reentrant VT in Langendorff-perfused rabbit hearts (n = 40). Three different mechanisms responsible for acceleration of VT were identified: 1) induction of double-wave reentry (n = 6), defined as the occurrence of two successive activation waves circulating in the same direction in the same circuit; 2) change to a functionally determined circuit (n = 4), defined as reentry of the impulse around a functional line of block without involvement of a fixed obstacle; and 3) change of the reentrant circuit to reentry within a different, faster anatomic pathway (n = 3). Analysis of 81 episodes of sustained monomorphic VT induced by PES in 74 patients with clinically documented sustained VT in the setting of chronic coronary artery disease showed that in 22 episodes VT was suddenly accelerated by PES (mean cycle length, from 345 +/- 73 to 277 +/- 71 msec, p less than 0.01).
  
  
  CONCLUSIONS
  With the observations made in the experimental model, the following tentative classification of the mechanisms of VT acceleration of the 22 episodes was made: 1) induction of double-wave reentry in two, 2) change to a functionally determined circuit in four, and 3) change to reentry within a faster anatomic circuit in 16. Simple criteria suggest that these mechanisms may apply in the clinical situation.
authors.affiliation: Department of Physiology, University of Limburg, Maastricht, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Brugada
authors.forename: P
authors.initials: P
authors.lastname: Brugada
authors.forename: L
authors.initials: L
authors.lastname: Boersma
authors.forename: L
authors.initials: L
authors.lastname: Mont
authors.forename: C
authors.initials: C
authors.lastname: Kirchhof
authors.forename: H J
authors.initials: HJ
authors.lastname: Wellens
authors.forename: M A
authors.initials: MA
authors.lastname: Allessie
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D013610:Tachycardia / Q000503:physiopathology*