Genetic polymorphism of six plasma proteins in the domestic cat.
Phenotypes of cat plasma apolipoprotein A4 (APOA4), antithrombin 3 (AT3), alpha 1B-glycoprotein (A1BG), transferrin (TF), vitamin D-binding protein (GC), and an unidentified pretransferrin (PTF) were determined by using simple methods of horizontal, nondenaturing gel electrophoresis followed by protein staining. The cat proteins were identified by immunoblotting using antisera for human plasma proteins. Three alleles were reported for each of TF and PTF, and two alleles were reported for each of GC, APOA4, AT3, and A1BG. The mongrels and Persians showed a high degree of polymorphism at most of the loci whereas the Birmans exhibited much less variation. Genetic evidence indicating the occurrence of a monomeric and a dimeric form of APOA4 in cat plasma was reported.
Juneja
R K
RK
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
Niini
T
T
Larsson
H E
HE
Sandberg
K
K
D000818:Animals; D000990:Antithrombin III / Q000235:genetics; D001054:Apolipoproteins A / Q000235:genetics; D001798:Blood Proteins / Q000235:genetics*; D002415:Cats / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D015151:Immunoblotting; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics; D014168:Transferrin / Q000235:genetics; D014809:Vitamin D-Binding Protein / Q000235:genetics
D001054:Apolipoproteins A; D001798:Blood Proteins; D011498:Protein Precursors; D014168:Transferrin; D014809:Vitamin D-Binding Protein; C022205:apolipoprotein A-IV; C041506:pretransferrin; D000990:Antithrombin III