[The effectiveness of CDDP in metastatic adenocarcinoma with unknown origin].
A 28-year-old man with inoperable metastatic adenocarcinoma in the retroperitoneum was referred to our hospital for a further evaluation for its origin. The tumor was measured 80 x 107 mm by abd. U.S. and showed papillary adenocarcinoma, histologically. Chemotherapy with intravenous administration of CDDP at the dose of 80 mg/m2 for 6 times at 2-3 week intervals was started, and CDDP concentration of binding-form and free-form in serum and urine were measured in time course. The tumor has reduced for 29 weeks after the discontinuance of CDDP. Free-CDDP, which was thought to have an anticancerous effect, immediately went up high levels in serum and rapidly excreted to urine, while total-CDDP in serum remained in high concentration for more than 10 weeks. Thus it was suggested that anticancerous effect of CDDP could not be contributed only to free-CDDP and the mechanism of CDDP will be clarified by the elucidation of metabolism of both free and total CDDP, especially in the tumor tissue.
Hara
T
T
Showa University 2nd. Internal Medicine.
Ogawa
M
M
Mukai
T
T
Watanabe
Y
Y
Ishii
M
M
Nagumo
A
A
Taguchi
S
S
Hatta
Y
Y
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D000328:Adult; D002945:Cisplatin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009382:Neoplasms, Unknown Primary; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*
D002945:Cisplatin