Role of neurotensin in radiation-induced hypothermia in rats.
The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin.
Kandasamy
S B
SB
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
Hunt
W A
WA
Harris
A H
AH
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000528:radiation effects*; D007036:Hypothermia, Induced; D007276:Injections, Intraventricular; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D009496:Neurotensin