title: Normal P300 following extensive damage to the left medial temporal lobe.
abstract: Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.
authors.affiliation: Wellcome Brain Research Group, Department of Psychology, University of St Andrews, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Rugg
authors.forename: C D
authors.initials: CD
authors.lastname: Pickles
authors.forename: D D
authors.initials: DD
authors.lastname: Potter
authors.forename: R C
authors.initials: RC
authors.lastname: Roberts
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004193:Discrimination Learning / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D013702:Temporal Lobe / Q000503:physiopathology*