How does p21ras transform cells?
Oncogenic forms of p21ras are found in a wide range of human tumors. However, the mechanism by which p21ras transforms remains obscure. Genetic evidence has identified a domain of p21ras that is involved with interaction with an effector molecule required for transformation. Two proteins, GAP and the tumor suppressor NF1, interact with p21ras in this region but it is an unresolved puzzle whether either of these is the an unresolved puzzle whether either of these is the effector. After interaction with an effector, two downstream events--activation of protein kinase C and another pathway--are necessary for induction of DNA synthesis by oncogenic p21ras; however, morphological transformation does not require activation of protein kinase C.
Marshall
C J
CJ
Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D004789:Enzyme Activation; D020690:GTPase-Activating Proteins; D006801:Humans; D025542:Neurofibromin 1; D015689:Oncogene Protein p21(ras) / Q000235:genetics* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D025542:Neurofibromin 1; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D011493:Protein Kinase C; D015689:Oncogene Protein p21(ras)