The effects of discrete gap junction coupling on propagation in myocardium.
A modified cable theory for a bi-domain model of myocardium that incorporates the effect of gap junctions as discrete objects coupling cardiac cells is derived. The theory is shown to be in agreement with a number of experiments that cannot be explained using standard continuous cable theory, and resolves some apparent contradictions on failure of propagation in two-dimensional anisotropic tissue. In addition, some as yet untested predictions of the theory are mentioned.
Keener
J P
JP
Department of Mathematics, University of Utah, Salt Lake City 84112.
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D008433:Mathematics; D008955:Models, Cardiovascular; D009206:Myocardium / Q000166:cytology*