The unusually high immunomodulatory activity of thymopentin analogue Pro5-TP-5.
The immunomodulatory potency of a series of proline-containing thymopentin (TP-5) analogues was investigated by PFC (in vitro and in vivo) test and by GvH reaction. It was found that the substitution of Asp in position 3 of TP-5 by D-Pro yields a distinctly more active compound than that obtained by substitution of Asp3 by L-Pro. Pro5-TP-5 showed very strongly enhanced activity as compared with TP-5; the effect is especially well obvious in PFC in vitro (15-fold enhancement of activity).
Wieczorek
Z
Z
Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Voelter
W
W
Nawrocka-Bolewska
E
E
Zimecki
M
M
Siemion
I Z
IZ
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D011392:Proline; D013154:Spleen / Q000166:cytology; D013329:Structure-Activity Relationship; D016305:Thymopentin / Q000494:pharmacology*
D009842:Oligopeptides; D011392:Proline; D016305:Thymopentin