title: Sedation effect on temporary threshold shift induced by acoustic overstimulation.
abstract: The mechanism by which noise damages the inner ear has not as yet been fully elucidated. Experiments were done to study the influence of the sedation in temporary threshold shift (TS) induced by acoustic overstimulation, as barbiturates were found to improve the brain's tolerance to ischemia. Four groups of guinea pigs (GP) were used. The temporary TS was decreased with the reduction of the temperature in awake, as well as sedated, sound-exposed GP. However, the temporary TS in the sedated, but normothermic GP was as great as in the awake, normothermic group. The high temperature counteracts the protection effect of the sedation in nose-induced hearing loss.
authors.affiliation: School of Health Professions, Department of Communication Disorders, Speech, Language and Hearing, Sackler Faculty of Medicine, Tel Aviv University, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Hildesheimer
authors.forename: Y
authors.initials: Y
authors.lastname: Henkin
authors.forename: C
authors.initials: C
authors.lastname: Muchnik
authors.forename: R
authors.initials: R
authors.lastname: Anafi
authors.forename: E
authors.initials: E
authors.lastname: Sahartov
authors.forename: M
authors.initials: M
authors.lastname: Rubinstein
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D001831:Body Temperature; D006224:Cricetinae; D006317:Hearing Loss, Noise-Induced / Q000209:etiology / Q000517:prevention & control; D009622:Noise / Q000009:adverse effects*; D010424:Pentobarbital / Q000494:pharmacology
chemical_list: D010424:Pentobarbital