title: Relations between on-off phenomena and cognitive functions in Parkinson disease.
abstract: 10 patients with Parkinson disease on long term levodopa therapy and with fluctuations in motor performance unrelated to drug administration (on-off phenomena) were assessed on the following neuropsychological tests during the on and off phases: tests of attention (Toulouse-Pieron), memory (Digit Span, Rey forms 1 and 2), psychomotor capacity (maze test, single and multiple choice reaction times) and mood (Maudley Adjective Check List). The extrapyramidal symptoms were assessed on the Webster Rating Scale. We found no significant differences in attention, cognitive performance or mood between the on and off phases despite large fluctuations in motor performance.
authors.affiliation: Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Meco
authors.forename: V
authors.initials: V
authors.lastname: Bonifati
authors.forename: L
authors.initials: L
authors.lastname: Bedini
authors.forename: A
authors.initials: A
authors.lastname: Bellatreccia
authors.forename: N
authors.initials: N
authors.lastname: Vanacore
authors.forename: A
authors.initials: A
authors.lastname: Franzese
mesh_terms: D000339:Affect; D003071:Cognition; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D011597:Psychomotor Performance
chemical_list: D007980:Levodopa