title: In vivo 1H-spectroscopy of human intracranial tumors at 1.5 tesla. Preliminary experience at a clinical installation.
abstract: Magnetic resonance spectroscopy (MRS) may contribute to the characterization of intracranial tumors in vivo. Volume selective water suppressed proton spectroscopy offers the possibility to study a number of metabolites in the brain including choline (CHO), creatinine/phosphocreatinine (CR/PCR), N-acetylaspartate (NAA), and lactate. Using the stimulated echo technique we have studied 17 patients with intracranial tumors. In all cases the tumors were classified based on histologic evaluation. The tumor spectra differed considerably from those obtained in healthy brain tissue. The results indicate a relative decrease in the NAA and CR/PCR content. In many cases a lactate peak could be seen especially in the tumors with malignant growth characteristics. Our preliminary results suggest that proton spectroscopy may contribute to the differentiation of brain tumors with respect to benign or malignant growth. However, further research is warranted before a definite conclusion can be drawn.
authors.affiliation: Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, Copenhagen.
authors.forename: O
authors.initials: O
authors.lastname: Henriksen
authors.forename: S
authors.initials: S
authors.lastname: Wieslander
authors.forename: F
authors.initials: F
authors.lastname: Gjerris
authors.forename: K M
authors.initials: KM
authors.lastname: Jensen
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001254:Astrocytoma / Q000175:diagnosis / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism; D008579:Meningioma / Q000175:diagnosis / Q000378:metabolism; D008875:Middle Aged; D009837:Oligodendroglioma / Q000175:diagnosis / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline