title: Calcium phosphate materials containing alumina: Raman spectroscopical, histological, and ultrastructural study.
abstract: Variable alumina quantities were added to two types of calcium phosphate materials-hydroxyapatite ceramics with Ca/P = 1.67 and calcium metaphosphate glass with Ca/P = 1--in order to increase their mechanical properties. Raman spectroscopy shows that alumina interacts with the phosphate group of these materials, while thermomechanical analysis shows that their elastic modulus has a value similar to that of bone. Histological sections demonstrate that the surface in close contact with ceramic materials shows a good integration between bone and biomaterial. All ceramic specimens are penetrated by well-stained, presumably glycoprotein, matrix, that consistently forms a thin network in close contact with the implant. After 6 weeks bone growing on both ceramic and glass shows signs of maturation with a lamellar structure and an apparently normal mineralization. In the case of the glass, inside this newly formed bone, were often observed two layers, the internal one showing a well defined lamellar structure.
authors.affiliation: Sezione di Chimica e Propedeutica Biochemica, Dipartimento di Biochimica, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertoluzza
authors.forename: R
authors.initials: R
authors.lastname: Simoni
authors.forename: A
authors.initials: A
authors.lastname: Tinti
authors.forename: M
authors.initials: M
authors.lastname: Morocutti
authors.forename: V
authors.initials: V
authors.lastname: Ottani
authors.forename: A
authors.initials: A
authors.lastname: Ruggeri
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000033:anatomy & histology / Q000601:surgery; D002130:Calcium Phosphates; D002516:Ceramics; D005898:Glass; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D051381:Rats; D013059:Spectrum Analysis, Raman
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D000537:Aluminum Oxide