Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats.
Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria. Depending on the degree and length of hyperoxaluria, CaOx crystals may either form in the nephron or the bladder and may or may not be retained in the kidneys. Crystals may nucleate in one part of the nephron and be retained in another part. Papillary collecting duct tubular epithelium and its basement membrane appear to be involved in crystal retention in the kidneys.
Khan
S R
SR
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610.
D000818:Animals; D002129:Calcium Oxalate; D003460:Crystallization; D006959:Hyperoxaluria / Q000150:complications / Q000503:physiopathology; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology / Q000503:physiopathology* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002129:Calcium Oxalate