Short-course antibiotic prophylaxis in penetrating abdominal injuries: ceftriaxone versus cefoxitin.
This was a prospective, randomized study of 123 patients with penetrating abdominal injuries. The patients received ceftriaxone or cefoxitin for 24 h (in the presence of colonic injury, 48 h). The overall incidence of abdominal sepsis was 7.3 per cent (ceftriaxone 5 per cent, cefoxitin 9.5 per cent, P greater than 0.05). Colonic injury was the most important risk factor for the development of septic complications. Other factors, such as the weapon used, a prehospital time longer than 4 h, shock on admission, multiple organ injuries, and small bowel perforation, did not influence the incidence of sepsis.
Demetriades
D
D
Department of Surgery, Baragwanath Hospital, South Africa.
Lakhoo
M
M
Pezikis
A
A
Charalambides
D
D
Pantanowitz
D
D
Sofianos
C
C
D000007:Abdominal Injuries / Q000601:surgery*; D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control; D002440:Cefoxitin / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D003106:Colon / Q000293:injuries; D005260:Female; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000150:complications; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D012307:Risk Factors; D014950:Wounds, Penetrating / Q000601:surgery*
D002440:Cefoxitin; D002443:Ceftriaxone