title: [Preparation of leukocyte-depleted thrombocyte concentrate: in-vitro testing of a new filtration system (PL 100)].
abstract: A newly developed filter-system (PL 100) for the removal of leukocytes from platelet concentrates was tested. It removes contaminating leukocytes by 99.7 +/- 0.6%. The platelet loss was calculated as 25.7 +/- 9.5%. The filtration process does not influence the filtered platelets; plasma-electrolytes, LDH-concentrations, platelet aggregation curves and serotonin-release remain constant. In addition, platelet ultrastructure is not influenced by the filtration. In spite of the high platelet loss, the tested filter-system seems to be a suitable alternative to the conventional methods for the removal of contaminating leukocytes from platelet concentrates.
authors.affiliation: Transfusionszentrum, Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Böck
authors.forename: S
authors.initials: S
authors.lastname: Himmelsbach
authors.forename: A
authors.initials: A
authors.lastname: Gudden
authors.forename: L
authors.initials: L
authors.lastname: Greither
authors.forename: W
authors.initials: W
authors.lastname: Mempel
mesh_terms: D001792:Blood Platelets / Q000648:ultrastructure; D001803:Blood Transfusion; D005374:Filtration / Q000295:instrumentation*; D006801:Humans; D007962:Leukocytes; D008212:Lymphocyte Depletion; D017713:Platelet Transfusion