title: Cytogenetics of multiple uterine leiomyomas, parametrial leiomyoma and disseminated peritoneal leiomyomatosis.
abstract: Using banding techniques the chromosomes were studied in 15 leiomyomas. The material comprised nine uterine myomas from one patient, one parametrial leiomyoma from a second patient and five tumors from a third patient with disseminated peritoneal leiomyomatosis. The results were considered together with pooled data from the literature. From this it could be concluded that: (1) each leiomyoma was the product of a separate clonal development; (2) different leiomyomas from the same patient sometimes showed an identical abnormal stemline (possibly because of etiological influences); (3) uterine and extra-uterine leiomyomas seemed to follow similar evolutionary pathways in their chromosomal progression.
authors.affiliation: Department of Cytogenetics, Central Hospital, Skövde, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Mark
authors.forename: G
authors.initials: G
authors.lastname: Havel
authors.forename: R
authors.initials: R
authors.lastname: Dahlenfors
authors.forename: B
authors.initials: B
authors.lastname: Wedell
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000235:genetics* / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology