title: Serum deoxythymidine kinase in adult T-cell leukemia-lymphoma and its related disorders.
abstract: Serum deoxythymidine kinase (TK) was measured in 15 patients with the acute type of adult T-cell leukemia (ATL), in 4 with chronic ATL, in 10 with lymphoma type ATL, in 9 with pre-ATL, in 11 with human T-cell leukemia virus type I (HTLV-I) associated with myelopathy (HAM) and in 19 HTLV-I carriers. All these patients were positive for anti-HTLV antibody. The level of TK in pretreatment serum was highest in acute ATL (15.6-1600 U/l, median 107 U/l). It was elevated in chronic ATL (5.4-55.0 U/l, median 37.6 U/l) and lymphoma ATL (6.8-316 U/l, median 16.8 U/l) but normal in pre-ATL (1.8-4.7 U/l, median 2.8 U/l), HAM (1.2-6.0 U/l, median 3.0 U/l) and HTLV-I carriers (1.1-4.6 U/l, median 2.3 U/l). Statistical examination revealed a significant difference between the levels of acute ATL and chronic ATL/lymphoma ATL. In the patients of this series, a close correlation between the level of TK and lactic dehydrogenase (LDH) was statistically present (p less than 0.01). These facts indicate that TK level is a useful indicator of the aggressiveness of ATL cells.
authors.affiliation: Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sadamori
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Mine
authors.forename: S
authors.initials: S
authors.lastname: Hakariya
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
authors.forename: M
authors.initials: M
authors.lastname: Ichimaru
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000201:enzymology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000201:enzymology; D011289:Preleukemia / Q000201:enzymology; D012016:Reference Values; D013937:Thymidine Kinase / Q000097:blood*
chemical_list: D007770:L-Lactate Dehydrogenase; D013937:Thymidine Kinase