title: Branchings and course of the larger ducts and accompanying structures within the rat submandibular salivary gland.
abstract: In the rat submandibular gland, the larger ducts, vessels, and autonomic elements are surrounded by appreciable collagen to form an extensive, ramifying core for the bulk of the parenchyma. This entity is analogous to the armature within a clay sculpture because it provides a framework supporting softer surroundings. Its largest portion, the trunk, begins dorsorostrally at the hilus. Along its caudal course, the trunk emits limbs that, in turn, branch. Rostrally, the trunk and major limbs have their greatest diameters and contain lymphatic vessels and autonomic ganglia that are fewer or absent in the smaller divisions. Four to six orders of branching commonly occur. This architectural device constitutes a physical gradient which peaks at the hilus and is minimal where its components undergo the transition to the lobular parenchyma. The presence of an appreciable amount of connective tissue, nerves, and larger vessels would make this entity firmer than the highly hydrated parenchyma. The major divisions of this grouping are contacted by septa that extend from the organ capsule and demarcate lobules into which smaller divisions penetrate. The parenchyma is consequently ensconced between several strong structures containing abundant connective tissue. The dense collagen encompassing individual components of the biological armature would stabilize duct epithelium and its intercellular channels as well as brace vessels' walls. As a result of this architectural arrangement, the patency of all acinar, duct, and vascular structures is likely to persist despite neck and jaw movements that would otherwise distort them and thus hinder the formation and flow of saliva during feeding. This mechanism may be widespread among organs.
authors.affiliation: Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007.
authors.forename: M
authors.initials: M
authors.lastname: Lorber
mesh_terms: D000818:Animals; D003094:Collagen / Q000648:ultrastructure; D003238:Connective Tissue / Q000033:anatomy & histology; D003239:Connective Tissue Cells; D005260:Female; D005724:Ganglia / Q000033:anatomy & histology / Q000166:cytology; D008208:Lymphatic System / Q000033:anatomy & histology / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000033:anatomy & histology* / Q000166:cytology
chemical_list: D003094:Collagen