title: The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes.
abstract: The efficacy of plaque control as a means of preventing cyclosporin-induced gingival overgrowth was assessed in 27 adult renal transplant patients. After baseline examination, patients were randomly allocated to receive intensive oral hygiene instructions, scaling and root planing (OH group) or no treatment (no treatment group). Gingival condition was assessed 6 months after baseline and changes in gingival form were related to various periodontal and pharmacokinetic measures. In both treatment groups, there was a significant increase (P less than 0.05) in gingival hyperplasia scores at 6 months. In the OH group, plaque scores were significantly lower (P less than 0.05) at 6 months, whereas in the no treatment group, a significant increase in plaque scores, gingival inflammation and probing depths was observed at 6 months. Dosages of cyclosporin, whole blood concentrations of cyclosporin, baseline gingival index, hyperplasia scores, and 6-month plaque index were not important determinants for the increase in gingival over-growth in both treatment groups. It is concluded that attention to plaque control and the removal of local irritants is of some benefit for the gingival health of cyclosporin-treated adult renal transplant patients, but these measures alone did not prevent gingival overgrowth. Pharmacokinetic variables of cyclosporin and various periodontal measures were not good predictors of cyclosporin-induced gingival changes.
authors.affiliation: Department of Operative Dentistry, Dental School, University of Newcastle-upon-Tyne, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Seymour
authors.forename: D G
authors.initials: DG
authors.lastname: Smith
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects* / Q000097:blood; D003773:Dental Plaque / Q000517:prevention & control*; D003777:Dental Prophylaxis; D012534:Dental Scaling; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D009910:Oral Hygiene; D010510:Periodontal Diseases / Q000517:prevention & control; D010512:Periodontal Index; D012044:Regression Analysis; D014092:Tooth Root / Q000601:surgery
chemical_list: D003524:Cyclosporins