Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease.
Resistance to insulin-stimulated glucose uptake and hyperinsulinemia may play a central role in the cause and clinical course of patients with non-insulin-dependent diabetes mellitus, high blood pressure, abnormalities of lipoprotein metabolism, and coronary heart disease. This article summarizes the evidence in support of this general hypothesis.
Reaven
G M
GM
Department of Medicine, Stanford University School of Medicine, CA.
D000818:Animals; D003327:Coronary Disease / Q000209:etiology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology* / Q000378:metabolism; D006949:Hyperlipidemias / Q000209:etiology* / Q000378:metabolism; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007333:Insulin Resistance; D013577:Syndrome