Possible common pathogenetic mechanisms for Poland sequence and Adams-Oliver syndrome.
We report on 2 families having members affected with the Poland sequence and Adams-Oliver syndrome. In the first family, a 5-month-old boy presented with Adams-Oliver syndrome; his mother had Poland sequence. In the second family, a 12-year-old boy and his mother presented with findings suggestive of Adams-Oliver syndrome and Poland sequence. This suggests that the same genetic predisposition may result in either or both conditions.
Der Kaloustian
V M
VM
Department of Pediatrics, Montreal Children's Hospital, Quebec, Canada.
Hoyme
H E
HE
Hogg
H
H
Entin
M A
MA
Guttmacher
A E
AE
D005260:Female; D005532:Foot Deformities, Congenital / Q000150:complications / Q000235:genetics*; D006228:Hand Deformities, Congenital / Q000150:complications / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D011045:Poland Syndrome / Q000150:complications / Q000235:genetics*; D012535:Scalp / Q000002:abnormalities*