title: The "adjuvant effect" of the polymorphic B-G antigens of the chicken major histocompatibility complex analyzed using purified molecules incorporated in liposomes.
abstract: The polymorphic B-G region of the chicken major histocompatibility complex has previously been shown to mediate an "adjuvant effect" on the humoral response to other erythrocyte alloantigens. We demonstrate here that B-G molecules purified with monoclonal antibodies exert this adjuvant effect on the production of alloantibodies to chicken class I (B-F) molecules, when the two are in the same liposome. The adjuvant effect may in part be mediated by antibodies, since the antibody response to B-G molecules occurs much faster than the response to B-F molecules, and conditions in which antibodies to B-G are present increase the speed of the response to B-F molecules. We also found that the presence of B-G molecules in separate liposomes results in a lack of response to B-F molecules. In the light of this and other data, we consider the possible roles for the polymorphic B-G molecules, particularly for the generation of B cell diversity, in the immune systems of birds and other animals.
authors.affiliation: Institute for Experimental Immunology, University of Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Salomonsen
authors.forename: H
authors.initials: H
authors.lastname: Eriksson
authors.forename: K
authors.initials: K
authors.lastname: Skjødt
authors.forename: T
authors.initials: T
authors.lastname: Lundgreen
authors.forename: M
authors.initials: M
authors.lastname: Simonsen
authors.forename: J
authors.initials: J
authors.lastname: Kaufman
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002645:Chickens / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004910:Erythrocyte Membrane / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D008081:Liposomes; D008285:Major Histocompatibility Complex; D011110:Polymorphism, Genetic
chemical_list: D000276:Adjuvants, Immunologic; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; D007519:Isoantigens; D008081:Liposomes