title: [Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis].
abstract: From January 1978 to August 1990, Staphylococcus aureus bacteremia (SAB) were identified in 31 patients with hematological malignancies at Jichi Medical School hospital. Mortality due to SAB was 48.4% (15/31). Of the variables analyzed, four factors were significantly associated with a poor prognosis; elderly age (p = 0.015), high granulocyte count (more than 500/microliters) (p = 0.015), presence of DIC (p = 0.011) and presence of pneumonia (p = 0.023). The incidence of methicillin-resistant SAB was 32.3% (10/31) and the first patient developed in 1985. Although not statistically significant, there was a trend of higher mortality for methicillin-resistant SAB (70%) than for methicillin-sensitive SAB (38.1%). Most strains of methicillin-resistant Staphylococcus aureus were sensitive to minocycline, chloramphenicol and vancomycin.
authors.affiliation: Department of Medicine, Jichi Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Kurata
authors.forename: S
authors.initials: S
authors.lastname: Imagawa
authors.forename: M
authors.initials: M
authors.lastname: Hoshino
authors.forename: J
authors.initials: J
authors.lastname: Tsunoda
authors.forename: H
authors.initials: H
authors.lastname: Ema
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002701:Chloramphenicol / Q000494:pharmacology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D008911:Minocycline / Q000494:pharmacology; D011379:Prognosis; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000209:etiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D002701:Chloramphenicol; D014640:Vancomycin; D008911:Minocycline