DNA analysis of cardiac myxomas: flow cytometry and image analysis.
Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2/M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.
Seidman
J D
JD
Research Service, Department of Veterans Affairs Medical Center, Baltimore, MD.
Berman
J J
JJ
Hitchcock
C L
CL
Becker
R L
RL
Mergner
W
W
Moore
G W
GW
Virmani
R
R
Yetter
R A
RA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm