Increased prevalence of glucose-6-phosphate dehydrogenase deficiency in patients with cholelithiasis.
The glucose-6-phosphate dehydrogenase (G6PD) enzyme activity was determined in 299 Northern Sardinian patients with cholelithiasis. Sixteen (12.80%) of the 125 male patients studied were G6PD deficient; 33 (18.96%) of the 174 females were heterozygous and 1 (0.57%) homozygous. Thus, the prevalence of G6PD deficiency in male subjects with cholelithiasis is about 35% higher (p less than 0.02) than that of a normal male control group (7.29%). As regards female patients, the incidence of the GdMed allele was also significantly different (p less than 0.05). Thus, G6PD-deficient subjects may have a predisposition to develop gallstones, even in the absence of clinical signs of chronic hemolysis.
Meloni
T
T
Clinica Pediatrica A. Filia Università, Sassari, Italia.
Forteleoni
G
G
Noja
G
G
Dettori
G
G
Sale
M A
MA
Meloni
G F
GF
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002769:Cholelithiasis / Q000150:complications*; D005260:Female; D005838:Genotype; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics