Epidermal growth factor suppresses the tumor growth of human breast cancer transplanted in nude mice.
The present work was performed in order to clarify the effects of epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) on the tumor growth of human breast cancer transplanted in nude mice. A local injection of 2 micrograms EGF significantly suppressed the tumor growth of human breast cancer MX-1 and primary breast tumor (UM-1) which was first isolated from a human female breast cancer patient in our laboratory. On the other hand, TGF-beta did not suppress the growth of those tumors. Our result indicates that human EGF may be useful as a therapeutic agent for some human breast cancers. Human EGF may lead to a new trend of therapy in the treatment of cancer.
Murayama
Y
Y
Second Department of Surgery, School of Medicine, Tokyo Medical and Dental University, Japan.
Mishima
Y
Y
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D016212:Transforming Growth Factor beta / Q000627:therapeutic use
D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor