title: Mouse ferritin H sequences map to chromosomes 3, 6, and 19.
abstract: Human and rodent genomes contain multiple copies of ferritin H and L subunit sequences, although it is not yet clear whether there is more than one expressed gene for either of these subunits. We have isolated a cDNA corresponding to mouse ferritin H subunit and observed that the mouse genome contains three to four H-related sequences. This cDNA was used to establish the genomic location of mouse ferritin H subunit genes by chromosomal in situ hybridization. Metaphase chromosomes of concanavalin A-stimulated lymphocytes from a WMP male mouse were examined by in situ hybridization with 3H-labeled cDNA and the chromosomes were identified by R banding (fluorochrome-photolysis-Giemsa method). The results indicate that mouse ferritin H-related sequences map at chromosomes 3, 6, and 19. Homology of synteny between human and mouse suggests that the sequence on mouse chromosome 19 corresponds to the structural H gene.
authors.affiliation: Laboratoire de Genetique Moleculaire, Faculte X. Bichat, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Yachou
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: N
authors.initials: N
authors.lastname: Roeckel
authors.forename: B
authors.initials: B
authors.lastname: Grandchamp
authors.forename: C
authors.initials: C
authors.lastname: Beaumont
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005293:Ferritins / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid
chemical_list: D005293:Ferritins