title: A preliminary study of mechanically stress-induced changes in the extracellular matrix of the canine intervertebral disc.
abstract: The intervertebral discs of a young (age, 3 years) and an old (age, 8 years) dog were isolated as motion segments and cyclically stressed in physiologic nondestructive axial compression loads. Chemical analysis of the matrix of the annulus fibrosus revealed a shift in proteoglycan molecular size from larger to smaller moieties for the older dog but not for the younger. These preliminary results may indicate an age-related inability of the disc to tolerate cyclic stress.
authors.affiliation: Department of Anatomy, UMDNJ-New Jersey Medical School, Newark.
authors.forename: N S
authors.initials: NS
authors.lastname: Vasan
authors.forename: E W
authors.initials: EW
authors.lastname: Gutteling
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Cibischino
authors.forename: J R
authors.initials: JR
authors.lastname: Parsons
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D002850:Chromatography, Gel; D004285:Dogs; D005109:Extracellular Matrix / Q000737:chemistry / Q000502:physiology*; D007403:Intervertebral Disc / Q000502:physiology*; D011509:Proteoglycans / Q000032:analysis*; D013314:Stress, Mechanical
chemical_list: D011509:Proteoglycans