title: Leukemia in a child with a history of medulloblastoma.
abstract: Leukemia of mixed lineage, was diagnosed in a 6.5-year-old boy with a history of medulloblastoma, 38 months after his initial cancer diagnosis. Therapy had included craniospinal radiation and nitrosourea-based chemotherapy. In addition, onset of leukemia was preceded by therapy with recombinant growth hormone for short stature. Although rare, leukemia is a treatment-related complication for patients with past brain tumors whose follow-up should therefore include surveillance with complete blood counts.
authors.affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, PA 15213.
authors.forename: J
authors.initials: J
authors.lastname: Blatt
authors.forename: L
authors.initials: L
authors.lastname: Penchansky
authors.forename: C
authors.initials: C
authors.lastname: Phebus
authors.forename: M
authors.initials: M
authors.lastname: Horn
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D002675:Child, Preschool; D013006:Growth Hormone / Q000009:adverse effects; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D008297:Male; D008527:Medulloblastoma / Q000628:therapy*
chemical_list: D013006:Growth Hormone