Predictive patch testing of "Medigloves" on humans using the repeated insult technique.
The predictive patch tests using the repeated insult technique with pieces of ETO sterilized "Medigloves" on 200 human subjects showed negative allergic reactions in all cases. Therefore, the sensitizing potential of "Medigloves" is quite low, if any. Mild to severe forms of miliaria rubra were occasionally observed in about one fourth of the subjects during the induction and challenge periods since the weather was quite warm and humid. However, three subjects who developed more pronounced miliaria rubra on the skin underneath rubber-glove squares were selected for provocative use tests. The results were negative in all cases. A subject who showed a false-positive allergic reaction also showed negative results in a provocative use test and in patch tests with standard rubber chemicals and pieces of "Medigloves" from various batches. Occlusive patch tests for 72 hours with Mediglove pieces from the same batch used in the initial test challenge phase were repeatedly negative when performed during the cool time of the year. In tropical countries, predictive closed patch tests employing solid occlusive materials should be done during cool weather in order to prevent or minimize the occurrence of miliaria. In hot weather, this is a common source of false positive reactions.
Timpatanapong
P
P
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bankok, Thailand.
Charuwichitratana
S
S
Rajatanavin
N
N
Sakuntapai
A
A
D000328:Adult; D002980:Climate; D003877:Dermatitis, Contact / Q000209:etiology*; D005189:False Positive Reactions; D005260:Female; D005542:Forearm; D005932:Gloves, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D008883:Miliaria / Q000139:chemically induced / Q000209:etiology*; D010328:Patch Tests / Q000379:methods; D012867:Skin / Q000276:immunology