Dioxamycin, a new benz[a]anthraquinone antibiotic.
A new antibiotic, dioxamycin (1) was isolated from the culture broth of the strain MH406-SF1, which was closely related to Streptomyces xantholiticus. This antibiotic was purified by countercurrent chromatography, column chromatography and preparative HPLC. The molecular formula of 1 was determined to be C38H40O15 by HRFAB-MS. The structure was determined by spectral analysis of 2D NMR; 1H-1H COSY, 13C-1H COSY, long range 13C-1H COSY (HMBC) and NOESY. The antibiotic is active in vitro against Gram-positive bacteria and some tumor cells. Dioxamycin is a benz[a]anthraquinone antibiotic related to capoamycin.
Sawa
R
R
Institute of Microbial Chemistry, Tokyo, Japan.
Matsuda
N
N
Uchida
T
T
Ikeda
T
T
Sawa
T
T
Naganawa
H
H
Hamada
M
M
Takeuchi
T
T
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C068893:dioxamycin