title: Gastroesophageal reflux disease. When antacids aren't enough.
abstract: Gastroesophageal reflux disease is a very common condition that is usually manifested by heartburn or regurgitation. Reflux esophagitis, caused by mucosal exposure to the backflow of caustic gastric contents, is primarily a result of lower esophageal sphincter dysfunction. Diagnostic workup varies but commonly includes esophagoscopy, 24-hour esophageal pH monitoring, and radiography of the upper gastrointestinal tract. Treatment, which progresses from simple life-style changes and antacids to histamine2 receptor antagonists to omeprazole (Prilosec) or surgery, is tailored to individual needs and is generally successful.
authors.affiliation: Department of Family Practice, Southern Illinois University, School of Medicine, Springfield, IL 62708.
authors.forename: J E
authors.initials: JE
authors.lastname: Sutherland
mesh_terms: D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000628:therapy; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans