title: Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs.
abstract: The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of low (approximately 5000 cp at 37 degrees C and 1 s-1), medium (15,000 cp), or high (30,000 cp) viscosity. Hydroxypropylmethylcellulose modified intralumenal viscosity, with a linear relationship existing between input and lumenal viscosity. With regard to transit, the lag time before the onset of chyme recovery increased linearly as a function of luminal viscosity. There was also a pronounced decrease in the first-order emptying rate constant as lumenal viscosity increased from water to low-viscosity hydroxypropylmethylcellulose, but as viscosity was further increased there was little additional change. These results indicate that water-soluble fibers can exert a significant influence on both the lumenal viscosity and the transit profile in the upper gastrointestinal tract.
authors.affiliation: College of Pharmacy, University of Michigan, Ann Arbor.
authors.forename: C
authors.initials: C
authors.lastname: Reppas
authors.forename: J H
authors.initials: JH
authors.lastname: Meyer
authors.forename: P J
authors.initials: PJ
authors.lastname: Sirois
authors.forename: J B
authors.initials: JB
authors.lastname: Dressman
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005766:Gastrointestinal Contents / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D014783:Viscosity / Q000187:drug effects; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose