What have we learnt from hyperbaric oxygen?
The 15 randomised controlled clinical trials of hyperbaric oxygen in radiotherapy yielded three with highly significant benefit and six with useful margins not reaching statistical significance. The increase in tumour control was partly negated by an increase in normal tissue effect. Now simple carbogen breathing in animal tumour models has shown high efficiency and there is the potential for its use in man as a simple means of hypoxic cell radiosensitization.
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Marie Curie Research Wing, Regional Centre for Radiotherapy and Oncology, Mount Vernon Hospital, Northwood, Middlesex, England.
D015687:Cell Hypoxia / Q000528:radiation effects*; D003131:Combined Modality Therapy; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy