title: Reduction of protein kinase C activity in the adult rat brain following transient forebrain ischemia.
abstract: Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia-induced decrease of PKC affected both the soluble and the membrane-bound kinase. Alterations of PKC predate neuronal death following ischemia.
authors.affiliation: Centre de Neurochimie du CNRS, Strasbourg, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Louis
authors.forename: E
authors.initials: E
authors.lastname: Magal
authors.forename: A
authors.initials: A
authors.lastname: Brixi
authors.forename: R
authors.initials: R
authors.lastname: Steinberg
authors.forename: E
authors.initials: E
authors.lastname: Yavin
authors.forename: G
authors.initials: G
authors.lastname: Vincendon
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002560:Cerebrovascular Circulation; D002546:Ischemic Attack, Transient / Q000201:enzymology*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D011493:Protein Kinase C