Use of technetium-99m(V)thiocyanate to measure gastric emptying of fat.
Technetium-99m(V)thiocyanate was evaluated as a radio-pharmaceutical for measuring gastric emptying of fat. Olive oil was labeled with 99mTc(V)thiocyanate by direct extraction from acidic thiocyanate solution. After incubation with dilute HCl (pH 1.4) at 37 degrees C for 3 hr, approximately 5% of the total radioactivity eluted into the aqueous phase. When incubated with human gastric juice (pH 1.8 and 2.2), approximately 8% of the activity was detected in the aqueous phase at 3 hr. Scintigraphic studies performed in two rabbits showed that olive oil labeled with 99mTc(V)thiocyanate emptied slowly from the stomach, with a gastric half-emptying time (T50) of more than 3 hr. A low-nutrient soup labeled with 113mIn-DTPA and mixed with 99mTc(V)thiocyanate labeled oil was consumed by six human volunteers. The oil emptied much more slowly (p less than 0.02) (median T50 = 198 min) than the aqueous component (median T50 = 30 min). These observations indicate that 99mTc(V)thiocyanate is a suitable pharmaceutical to measure gastric emptying of extracellular fat.
Cunningham
K M
KM
Department of Medicine, Royal Adelaide Hospital, South Australia.
Baker
R J
RJ
Horowitz
M
M
Maddox
A F
AF
Edelbroek
M A
MA
Chatterton
B E
BE
D000328:Adult; D000818:Animals; D004041:Dietary Fats; D005746:Gastric Emptying; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D000069463:Olive Oil; D015609:Organotechnetium Compounds; D010938:Plant Oils; D011817:Rabbits; D013861:Thiocyanates
D004041:Dietary Fats; D000069463:Olive Oil; D015609:Organotechnetium Compounds; D010938:Plant Oils; D013861:Thiocyanates; C068692:technetium Tc 99m(V)thiocyanate