Delayed excitatory reaction following interaction of cocaine and monoamine oxidase inhibitor (phenelzine).
A case report is presented in which a patient receiving the monoamine oxidase inhibitor, phenelzine, developed a delayed excitatory reaction following administration of topical cocaine spray during anaesthesia for vocal cord surgery. The pharmacological basis of the drug interaction is discussed.
Tordoff
S G
SG
Department of Anaesthesia, Poole General Hospital, Dorset.
Stubbing
J F
JF
Linter
S P
SP
D000368:Aged; D000772:Anesthesia, Local / Q000009:adverse effects*; D003042:Cocaine / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010624:Phenelzine / Q000009:adverse effects*; D012701:Serotonin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014827:Vocal Cords / Q000601:surgery*
D012701:Serotonin; D003042:Cocaine; D010624:Phenelzine