[Molecular genetics of heart diseases. A familial approach].
Cardiovascular diseases are the result of the interaction of genetic and environmental factors and constitute a complex group of monogenic and, above all, polygenic pathologies. The possibility of localising the responsible genetic factors on the chromosomes by the study of families may eventually enable a predictive diagnosis, better orientation of treatment and a fuller understanding of the interaction of the different cardiovascular risk factors. The family approach allows the confirmation or the elimination of the role of a given gene of major or minor expression because of the polymorphisms of DNA.
Junien
C
C
INSERM U 73, Paris.
D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006331:Heart Diseases / Q000235:genetics*; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D006938:Hyperlipoproteinemia Type II / Q000235:genetics; D008297:Male; D008382:Marfan Syndrome / Q000235:genetics; D008967:Molecular Biology; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers