title: Non-secretory adenomas of the pituitary treated by trans-ethmoidal sellotomy.
abstract: A consecutive series of 35 clinically non-secretory pituitary adenomas treated surgically by the transethmodial approach is presented. Mean age at presentation was 60 years, with a male-to-female ratio of 2:1. These tumours present later than hormone secreting tumours: 90% were over 2 cm in diameter at operation. Seventy-one per cent of patients had impaired vision and 89% had hypopituitarism. Surgical treatment relieved or significantly improved visual fields in 79% of patients with impaired vision. Ninety-one per cent required permanent hormone replacement. Mean follow-up was for 4.4 years. Five tumours recurred, causing recurrent visual symptoms. No tumours recurred in those patients treated with postoperative radiotherapy, but follow-up in this group was only for a mean of 2.7 years.
authors.affiliation: Department of Otolaryngology, University Hospital of Wales, Heath Park, Cardiff.
authors.forename: G R
authors.initials: GR
authors.lastname: Shone
authors.forename: S H
authors.initials: SH
authors.lastname: Richards
authors.forename: M D
authors.initials: MD
authors.lastname: Hourihan
authors.forename: R
authors.initials: R
authors.lastname: Hall
authors.forename: J P
authors.initials: JP
authors.lastname: Thomas
authors.forename: M F
authors.initials: MF
authors.lastname: Scanlon
mesh_terms: D000236:Adenoma / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D007018:Hypopituitarism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D014786:Vision Disorders / Q000209:etiology