[The effect of brilliant cresyl blue on erythrocyte degeneration in patients after acute stroke].
The authors investigated the disintegration of red cells by the action of brilliant cresyl blue in patients after an acute cerebrovascular attack and compared them with the disintegration in blood donors. In the patients the disintegration was assessed within 24 hours after the attack and after one year. The disintegration was assessed in two incubation solutions i.e. in isotonic saline and in Krebs-Ringer solution after three hours incubation at 37 degrees C. It was revealed that in the control group the disintegration of erythrocytes in isotonic saline is much greater than in Krebs-Ringer solution. The difference between the action of the two solutions is highly significant. In patients immediately after the attack as well as in the group which did not survive the period of one year (7 patients) and the group which survived the period of one year (8 patients) the difference in disintegration in the two solutions is significant but at a lower level of significance. It is thus smaller than in the control group. However, in the group which survived for one year this difference is again highly significant, similarly as in the control group. The author discusses the problem of metabolic influencing of the elasticity and deformability of the red cell membrane and its impact on the rheology of blood.
Eiben
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Neurologická klinika LF UPJS a FNsP, Kosice.
Nicák
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D000368:Aged; D000369:Aged, 80 and over; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D010078:Oxazines / Q000494:pharmacology*
D010078:Oxazines; C006797:Brilliant Cresyl Blue