Mouse ferritin H sequences map to chromosomes 3, 6, and 19.
Human and rodent genomes contain multiple copies of ferritin H and L subunit sequences, although it is not yet clear whether there is more than one expressed gene for either of these subunits. We have isolated a cDNA corresponding to mouse ferritin H subunit and observed that the mouse genome contains three to four H-related sequences. This cDNA was used to establish the genomic location of mouse ferritin H subunit genes by chromosomal in situ hybridization. Metaphase chromosomes of concanavalin A-stimulated lymphocytes from a WMP male mouse were examined by in situ hybridization with 3H-labeled cDNA and the chromosomes were identified by R banding (fluorochrome-photolysis-Giemsa method). The results indicate that mouse ferritin H-related sequences map at chromosomes 3, 6, and 19. Homology of synteny between human and mouse suggests that the sequence on mouse chromosome 19 corresponds to the structural H gene.
Yachou
A
A
Laboratoire de Genetique Moleculaire, Faculte X. Bichat, Marseille, France.
Mattei
M G
MG
Roeckel
N
N
Grandchamp
B
B
Beaumont
C
C
D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005293:Ferritins / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid
D005293:Ferritins