Genotoxic evaluation of letimide with the mouse bone marrow micronucleus test.
Letimide, 3[2-(diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione, a new analgesic, is a cyclic derivative of a salicylamide with a higher pharmacological potency than acetylsalicylic acid. In this study we evaluated its clastogenic activity using the micronucleus test in vivo. Our results did not show any clastogenic effect produced by letimide as compared with control mice and animals treated with cyclophosphamide.
Díaz Barriga-Arceo
S
S
Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Mexico, D.F.
Madrigal-Bujaidar
E
E
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D010078:Oxazines / Q000633:toxicity*
D010078:Oxazines; C068350:letimide