title: Optimal dose of lignocaine for preventing pain on injection of propofol.
abstract: The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol. We conducted a prospective, randomized, double-blind trial on 310 patients undergoing anaesthesia. Patients were allocated to four groups according to the lignocaine dosage: group A (control), no lignocaine; group B, lignocaine 0.1 mg kg-1; group C, lignocaine 0.2 mg kg-1; group D, lignocaine 0.4 mg kg-1. Our results showed that a dose of lignocaine 0.1 mg kg-1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased.
authors.affiliation: Département d'Anesthésie-Réanimation, CHU Avicenne-Jean Verdier, Université Paris XIII, Bobigny, France.
authors.forename: G
authors.initials: G
authors.lastname: Gehan
authors.forename: P
authors.initials: P
authors.lastname: Karoubi
authors.forename: F
authors.initials: F
authors.lastname: Quinet
authors.forename: A
authors.initials: A
authors.lastname: Leroy
authors.forename: C
authors.initials: C
authors.lastname: Rathat
authors.forename: J L
authors.initials: JL
authors.lastname: Pourriat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D008012:Lidocaine; D015742:Propofol