title: Photoreactivity of 5-geranoxypsoralen and lack of photoreaction with DNA.
abstract: 5-Geranoxypsoralen, commonly called bergamottin, a major furocoumarin contained in bergamot oil, is reported in vitro as a highly photoreactive psoralen. In ethanol, it exhibits quite a high triplet state quantum yield (approximately 0.37). The triplet state is involved in subsequent photochemistry which depends on the initial concentration and on the presence of oxygen. In contrast to most psoralens, absorption and fluorescence data suggest that 5-geranoxypsoralen does not interact with DNA in the dark. No UVA-induced interstrand cross-links in DNA were shown.
authors.affiliation: Laboratoire de Dermatologie, INSERM U.312, Creteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Morlière
authors.forename: M
authors.initials: M
authors.lastname: Bazin
authors.forename: L
authors.initials: L
authors.lastname: Dubertret
authors.forename: R
authors.initials: R
authors.lastname: Santus
authors.forename: T
authors.initials: T
authors.lastname: Sa E Melo
authors.forename: G
authors.initials: G
authors.lastname: Hüppe
authors.forename: J
authors.initials: J
authors.lastname: Haigle
authors.forename: P
authors.initials: P
authors.lastname: Forlot
authors.forename: A
authors.initials: A
authors.lastname: Bernard
mesh_terms: D004247:DNA / Q000737:chemistry*; D011564:Furocoumarins / Q000737:chemistry*; D008730:Methoxsalen / Q000737:chemistry; D010777:Photochemistry; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*
chemical_list: D011564:Furocoumarins; D011838:Radiation-Sensitizing Agents; D004247:DNA; C068337:bergamottin; D008730:Methoxsalen