title: Macromolecular creatine kinase type 1: a serum marker associated with disease.
abstract: The prevalence of circulating macromolecular creatine kinase type 1 (macro CK type 1 or CK-immunoglobulin complexes) is significantly higher in a patient population selected for CK isoenzyme assay than in age- and sex-matched blood donors (n = 1304). In greater than 8000 patients studied, 49 individuals with macro CK type 1 were identified, yielding an overall prevalence of 0.61%. Macro CK type 1 complexes occurred more frequently in women and in patients older than 70 years, and were often associated with complications of cardiovascular disease, life-threatening conditions, and poor outcome. These latter clinical associations could arise, at least partly, from the selection of patients for whom CK isoenzyme analysis was ordered.
authors.affiliation: Department of Clinical Chemistry, Akademisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Laureys
authors.forename: J P
authors.initials: JP
authors.lastname: Sion
authors.forename: H
authors.initials: H
authors.lastname: Slabbynck
authors.forename: L
authors.initials: L
authors.lastname: Steenssens
authors.forename: C
authors.initials: C
authors.lastname: Cobbaert
authors.forename: M P
authors.initials: MP
authors.lastname: Derde
authors.forename: F K
authors.initials: FK
authors.lastname: Gorus
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001782:Blood Donors; D002318:Cardiovascular Diseases / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase