title: HIV replication and persistence in human gastrointestinal cells cultured in vitro.
abstract: Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months implies that the human gastrointestinal tract may serve as a site for primary infection and as a reservoir for the virus. Furthermore, HIV infection of SM cells may be an in vitro model of Kaposi's sarcoma.
authors.affiliation: Department of Surgery, University of Texas Health Science Center, San Antonio 78284-7842.
authors.forename: M P
authors.initials: MP
authors.lastname: Moyer
authors.forename: H E
authors.initials: HE
authors.lastname: Gendelman
mesh_terms: D002455:Cell Division; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003106:Colon / Q000166:cytology*; D003110:Colonic Neoplasms; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000166:cytology*; D007413:Intestinal Mucosa / Q000166:cytology*; D007583:Jejunum / Q000166:cytology*; D007700:Kinetics; D014779:Virus Replication