title: Hyperplasia of Brunner glands: the spectrum of its radiographic manifestations.
abstract: Radiographic features of the duodenal mucosa were analyzed in a series of 26 patients in whom the diagnosis of Brunner gland hyperplasis (BGH) had been established by endoscopic biopsies. The observed mucosal patterns could be classified into five categories: (1) focal BGH causing a solitary submucosal adenoma or a cluster of sessile polyps in the otherwise smooth duodenal bulb surface (five cases); (2) diffuse BGH manifested by a myriad of small and uniform mucosal elevations (six cases); (3) multifocal BGH producing large and well-demarcated polygonal masses (six cases); (4) BGH with concomitant acute and/or chronic duodenitis showing marked thickening and nodularity of duodenal folds (four cases); or (5) BGH with predominant erosive duodenitis, leading to ulcerations (five cases). These radiographic findings showed a good correlation with the endoscopic and histopathologic manifestations of BGH and the frequently coexistent duodenitis.
authors.affiliation: Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: D
authors.initials: D
authors.lastname: Merine
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: G G
authors.initials: GG
authors.lastname: Ghahremani
authors.forename: S R
authors.initials: SR
authors.lastname: Hamilton
authors.forename: T M
authors.initials: TM
authors.lastname: Bayless
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002011:Brunner Glands / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D004379:Duodenal Neoplasms / Q000000981:diagnostic imaging; D004382:Duodenitis / Q000000981:diagnostic imaging; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies