Subchronic exposure of Biomphalaria glabrata eggs to aridanin and niclosamide.
Treatment of 3-day-old Biomphalaria glabrata eggs with aridanin caused a knock-down effect on the prehatch snails, making this group the most susceptible. The development and hatching of 0- to 1-day-old eggs could not be prevented but was prolonged by continuous exposure to aridanin (0.5-10 mg/l). Prehatch snails were less susceptible than juvenile and adult snails. Niclosamide (0.625-0.35 mg/l) arrested the development of B. glabrata. The results predict a poor action of aridanin as an ovicidal agent in the control of snail intermediate hosts of schistosomiasis.
Adewunmi
C O
CO
Danish Bilharziasis Laboratory, Charlottenlund.
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D004199:Disease Vectors; D005260:Female; D008975:Molluscacides / Q000494:pharmacology; D009534:Niclosamide / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010063:Ovum / Q000187:drug effects; D012552:Schistosomiasis / Q000469:parasitology / Q000635:transmission; D013997:Time Factors
D008975:Molluscacides; D009828:Oleanolic Acid; C058029:aridanin; D009534:Niclosamide