title: Infrared spectroscopy of heparins suggests that the region 750-950 cm-1 is sensitive to changes in iduronate residue ring conformation.
abstract: By careful definition of polymer environment, heparin i.r. spectra were examined in a region (750-950 cm-1) in which sulphate half-ester absorptions occur. Changes seen in this region when metal ion-heparin complexes are converted into heparinic acid, when heparin is carboxy-group-reduced and when various concentrations of Li(+)-heparin are examined are tentatively interpreted in terms of changes in the ring conformation of iduronate residues.
authors.affiliation: Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, Scotland, U.K.
authors.forename: D
authors.initials: D
authors.lastname: Grant
authors.forename: W F
authors.initials: WF
authors.lastname: Long
authors.forename: C F
authors.initials: CF
authors.lastname: Moffat
authors.forename: F B
authors.initials: FB
authors.lastname: Williamson
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006493:Heparin / Q000737:chemistry*; D006497:Heparan Sulfate / Q000737:chemistry; D006860:Hydrogen Bonding; D007067:Iduronic Acid / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013431:Sulfates / Q000737:chemistry
chemical_list: D006493:Heparin; D006497:Heparan Sulfate; D007067:Iduronic Acid; D008094:Lithium; D013431:Sulfates