title: A prospective evaluation of myocardial contusion: correlation of significant arrhythmias and cardiac output with CPK-MB measurements.
abstract: Over a nine-month period, patients with chest trauma were prospectively evaluated for myocardial contusion. Ninety-two patients with evidence of anterior chest trauma were entered into the study and had 1) an ECG on admission and daily for three days; 2) monitoring of the myocardial band fraction of creatine phosphokinase (CPK-MB) on admission and every eight hours for 24 hours; 3) continuous electrocardiographic Holter monitoring for three to five days; and 4) noninvasive pulsed-Doppler cardiac output measurements daily for three days. Twenty-three patients developed 25 significant arrhythmias (SARRs): 1 atrial fibrillation, 1 AV dissociation, 5 supraventricular tachycardias, and 18 paroxysmal ventricular tachycardias. Cardiac outputs were significantly higher in those patients without SARRs. The CPK-MB levels correlated with the SARRs but were neither sensitive nor specific. No patients required specific therapy and none developed adverse sequelae of the SARRs. We conclude that 1) CPK-MB monitoring should not be routinely used for screening and diagnosis; 2) continuous arrhythmia monitoring deserves further clinical investigation but not routine application; 3) stable patients at risk for myocardial contusion should be monitored for 24 hours; and 4) the Abbreviated Injury Score for "minor" myocardial contusion should be deleted for purposes of ISS tabulation.
authors.affiliation: Department of Surgery, University of Tennessee Health Science Center, Memphis.
authors.forename: T C
authors.initials: TC
authors.lastname: Fabian
authors.forename: R S
authors.initials: RS
authors.lastname: Cicala
authors.forename: M A
authors.initials: MA
authors.lastname: Croce
authors.forename: L L
authors.initials: LL
authors.lastname: Westbrook
authors.forename: P A
authors.initials: PA
authors.lastname: Coleman
authors.forename: G
authors.initials: G
authors.lastname: Minard
authors.forename: K A
authors.initials: KA
authors.lastname: Kudsk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002302:Cardiac Output; D003288:Contusions / Q000503:physiopathology*; D003402:Creatine Kinase / Q000097:blood; D015716:Electrocardiography, Ambulatory; D005260:Female; D006335:Heart Injuries / Q000150:complications / Q000201:enzymology / Q000503:physiopathology*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013898:Thoracic Injuries / Q000503:physiopathology*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase