title: Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes.
abstract: Chromosome aberrations (CA) and sister-chromatid exchanges (SCE) were measured in lymphocytes of (A) 32 healthy individuals working in the flower industry and exposed to pesticides, (B) 32 individuals exposed as above and hospitalized for bladder cancer, and (C) 31 controls. Compounds to which floriculturists were exposed included 18 nitro-organic herbicides and fungicides, 9 nitro-organic fungicides, 12 organophosphate and organothiophosphate insecticides, 4 hydrocarbon derivative herbicides and 5 inorganic fungicides and insecticides. 150 and 70 metaphases per individual were scored for CA and SCE, respectively. A significant increase in the incidence of CA and SCE was observed in both exposed groups. Cancer patients showed the presence of rare rearrangements (dicentrics, rings and quadriradials) that were not observed in controls and were present at a lower frequency in healthy exposed people. Hyperdiploid and polyploid metaphases were also significantly increased in the 2 exposed groups compared to controls. Stratifying for age or smoking habits, although affecting the significance of individual data, did not change the substance of the results.
authors.affiliation: Laboratory of Mutagenesis, IST, Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Ferrari
authors.forename: M
authors.initials: M
authors.lastname: Artuso
authors.forename: S
authors.initials: S
authors.lastname: Bonassi
authors.forename: S
authors.initials: S
authors.lastname: Bonatti
authors.forename: Z
authors.initials: Z
authors.lastname: Cavalieri
authors.forename: D
authors.initials: D
authors.lastname: Pescatore
authors.forename: E
authors.initials: E
authors.lastname: Marchini
authors.forename: V
authors.initials: V
authors.lastname: Pisano
authors.forename: A
authors.initials: A
authors.lastname: Abbondandolo
mesh_terms: D000328:Adult; D000367:Age Factors; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D007558:Italy; D008875:Middle Aged; D008938:Mitosis / Q000187:drug effects; D016273:Occupational Exposure; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D010575:Pesticides / Q000506:poisoning*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking / Q000009:adverse effects
chemical_list: D005659:Fungicides, Industrial; D006540:Herbicides; D007306:Insecticides; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D010575:Pesticides