Pharmacological assay of Cordia verbenacea. III: Oral and topical antiinflammatory activity and gastrotoxicity of a crude leaf extract.
The antiinflammatory effects and gastrotoxicity of a lyophilized 70% ethanol extract of the leaves of Cordia verbenacea were investigated through experimental models in rats and mice. The oral administration of 1.24 mg/kg of the extract significantly inhibited nystatin-induced oedema. Topical application of the extract at a dose of 0.09 mg/ear in mice was clearly more effective than 1.0 mg/ear of naproxen in the reduction of the ear oedema induced by corton oil. At antiinflammatory doses, the extract showed an important protective effect on the gastric mucosa, reducing significantly the number of gastric lesions.
Sertié
J A
JA
Department of Pharmacology, Universidade de Säo Paulo, Brazil.
Basile
A C
AC
Panizza
S
S
Oshiro
T T
TT
Azzolini
C P
CP
Penna
S C
SC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000302:isolation & purification* / Q000633:toxicity; D003872:Dermatitis / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts