Developmental appearance of proteins identified by two-dimensional gel electrophoresis in mouse gonadal tissue.
Gonadal protein patterns of the mouse were studied during fetal development by two-dimensional gel electrophoresis. Fetal mice at days 8.5, 10.5, 12.5, and 14.5 post-coitum were analyzed for male or female specific proteins. Although no sex specific proteins were found, several proteins were found which were expressed in significantly different amounts in the two sexes at about the time of gonadal differentiation. Hence, quantitative differences, rather than qualitative ones, could be related to the initiation of testis or ovary development.
Durbin
E J
EJ
Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor.
Erickson
R P
RP
Van Keuren
M L
ML
Iacob
R A
RA
Kurnit
D M
DM
D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D005326:Fetal Proteins / Q000096:biosynthesis*; D006066:Gonads / Q000196:embryology* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D012733:Sex Differentiation / Q000502:physiology*
D005326:Fetal Proteins