title: Effect of simultaneous ingestion of L-amino acids and whole protein on plasma amino acid and urea nitrogen concentrations in humans.
abstract: The effect of whole protein and L-amino acid ingestion on plasma amino acid (PAA) and urea nitrogen (UN) concentrations was investigated. Ten males ingested equivalent amounts of nitrogen as (trial 1) cottage cheese, (trial 2) an L-amino acid mixture, (trial 3) cottage cheese and L-amino acids. Mean changes in total PAA between trials 1 (342 mumol/liter) and 2 (719 mumol/liter) and trials 1 (342 mumol/liter) and 3 (981 mumol/liter) at 30 min and trials 1 (547 mumol/liter) and 3 (143 mumol/liter) at 150 min differed significantly. Mean changes in essential PAA between trials 1 (180 mumol/liter) and 2 (420 mumol/liter) and trials 1 (180 mumol/liter) and 3 (500 mumol/liter) at 30 min differed significantly. Mean changes in essential PAA between trials 1 (247 mumol/liter) and 3 (334 mumol/liter) at 60 min and between trials 1 (252 mumol/liter) and 3 (80 mumol/liter) at 150 min differed significantly. Mean increments in total and essential PAA were higher and peaked faster but decreased more quickly after trials 2 and 3 than after trial 1. Mean changes in plasma UN did not differ between trials. Ingestion of either L-amino acids, whole protein or the mixture of L-amino acids and whole protein was equally effective in increasing total PAA over 4 hr.
authors.affiliation: Department of Nutrition, Florida State University, Tallahassee.
authors.forename: S S
authors.initials: SS
authors.lastname: Gropper
authors.forename: P B
authors.initials: PB
authors.lastname: Acosta
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001806:Blood Urea Nitrogen; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D005215:Fasting; D006801:Humans; D008297:Male
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins