title: Naturally occurring benzodiazepines in human milk.
abstract: The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines. The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 +/- 0.74 ng in male plasma; to 2.20 +/- 0.35 ng in female plasma and to 1.91 +/- 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.
authors.affiliation: Instituto de Biología Celular, Facultad de Medicina, (UBA-CONICET), Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Peña
authors.forename: J H
authors.initials: JH
authors.lastname: Medina
authors.forename: M
authors.initials: M
authors.lastname: Piva
authors.forename: L E
authors.initials: LE
authors.lastname: Diaz
authors.forename: C
authors.initials: C
authors.lastname: Danilowicz
authors.forename: A C
authors.initials: AC
authors.lastname: Paladini
mesh_terms: D001569:Benzodiazepines / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy; D011869:Radioligand Assay; D012016:Reference Values
chemical_list: D001569:Benzodiazepines