[Chlamydia trachomatis infection in women and the use of oral contraceptives].
We determined the prevalence of genital Chlamydia trachomatis infection in women who visited a clinic for sexually transmitted diseases (STD) and the influence of the number of partners and the use of oral contraceptives (OC), with special attention to the recognition of pelvic inflammatory disease (PID) and to the results of therapy. Of 217 women, with a mean age of 26 years (range 14-56), who visited the STD clinic of the University Hospital of Groningen from July 1985 until November 1987, anamnestic data were collected as well as the results of swabs from cervix and urethra taken for culture and direct immunofluorescence test of C. trachomatis and for gonococcal culture. The influence of the number of partners (1 versus greater than 1) and OC on the prevalence of C. trachomatis infection was evaluated by logistic regression analysis. PID was excluded in coöperation with the department of gynaecology. C. trachomatis-infected women were treated by doxycycline orally (day 1 2 x 100 mg, day 2-7 1 x 100 mg) according to the dosage scheme advised by the Dutch Health Council in 1986. A control culture was taken 2-3 weeks after treatment. C. trachomatis was detected in 72/217 (33%) women by culture and (or) direct IF test and in 22/41 (54%) women with gonorrhoea. In connection with the number of partners in the year preceding the examination, the following prevalences were found: 18/74 (24%) (1 partner), 43/108 (40%) (2-5 partners) and 10/27 (greater than 5 partners).(ABSTRACT TRUNCATED AT 250 WORDS)
van Voorst Vader
P C
PC
Afd. Dermatovenereologie, Academisch Ziekenhuis, Groningen.
Lier
J G
JG
Posma
A L
AL
Schröder
F P
FP
Schirm
J
J
Kauer
F M
FM
D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D003276:Contraceptives, Oral / Q000008:administration & dosage; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D000292:Pelvic Inflammatory Disease / Q000382:microbiology; D015995:Prevalence; D012044:Regression Analysis
D003276:Contraceptives, Oral; D004318:Doxycycline