Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19.
A DNA polymorphism for the mouse retinol binding protein has been identified using the enzyme BamHI and a rat partial cDNA probe. Analysis of the polymorphism in DNA from 64 inbred mouse strains demonstrated the presence of a single gene with two alleles, Rbp-4b and Rbp-4d. Comparison of the segregation patterns of these alleles in three sets of recombinant inbred strains with allele segregation patterns of previously characterized loci shows that the Rbp-4 locus is closely linked to the locus for phenobarbital-inducible cytochrome P450-2c (Cyp-2c) that has been shown by in situ hybridization to lie on chromosome 19, bands D1-D2. The Rbp-4 locus is just proximal to Cyp-2c at the distal end of chromosome 19.
Chainani
M
M
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, New York State Department of Health, Buffalo 14263.
Sampsell
B
B
Elliott
R W
RW
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D008040:Genetic Linkage; D051379:Mice; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D051381:Rats; D012177:Retinol-Binding Proteins / Q000235:genetics*; D054839:Retinol-Binding Proteins, Plasma
D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma