title: The androgen receptor gene is located on a highly conserved region of the X chromosomes of marsupial and monotreme as well as eutherian mammals.
abstract: The androgen receptor gene (AR), which is located on the long arm of the human X chromosome, was mapped by somatic cell analysis and in situ hybridization in marsupial and monotreme species. Both methods demonstrated that it was located on the X chromosome in each marsupial species, and also in the platypus. We conclude that this gene is part of a highly conserved region of the mammalian X, represented by the human Xq, which formed part of the X chromosome in a mammalian ancestor 150 million years ago. Since this gene is located proximally on the long arm of the monotreme X, which is G-band homologous to the Y and apparently exempt from X chromosome inactivation, the conservation of this region has evidently not depended on its isolation by X-Y differentiation or on X inactivation.
authors.affiliation: Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
authors.forename: J A
authors.initials: JA
authors.lastname: Spencer
authors.forename: J M
authors.initials: JM
authors.lastname: Watson
authors.forename: D B
authors.initials: DB
authors.lastname: Lubahn
authors.forename: D R
authors.initials: DR
authors.lastname: Joseph
authors.forename: F S
authors.initials: FS
authors.lastname: French
authors.forename: E M
authors.initials: EM
authors.lastname: Wilson
authors.forename: J A
authors.initials: JA
authors.lastname: Graves
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D015342:DNA Probes; D006801:Humans; D008394:Marsupialia / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010987:Platypus / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D011944:Receptors, Androgen