title: Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects.
abstract: The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.
authors.affiliation: Departamento de Farmacologia do Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Oga
authors.forename: S F
authors.initials: SF
authors.lastname: Taniguchi
authors.forename: R
authors.initials: R
authors.lastname: Najjar
authors.forename: A R
authors.initials: AR
authors.lastname: Souza
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D004487:Edema / Q000188:drug therapy*; D005480:Flurbiprofen / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000502:physiology*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C068597:copper flurbiprofen complex; D005480:Flurbiprofen