title: The configuration of mitiromycin and its derivation from mitomycin B.
abstract: The configuration of mitiromycin (2) was first determined by NMR experiments including the NOE technique. The absolute structure of 2 was related to mitomycin B (3) because 2 was derived from 3 under basic conditions. The ketonic form 4 was presumed to be involved in the generation of 2.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kono
authors.forename: M
authors.initials: M
authors.lastname: Kasai
authors.forename: K
authors.initials: K
authors.lastname: Shirahata
authors.forename: N
authors.initials: N
authors.lastname: Hirayama
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008937:Mitomycins / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
chemical_list: D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; C068816:mitiromycin; C046000:mitomycin A