Acute lymphoblastic leukemia with t(4;11) translocation after osteogenic sarcoma.
The authors report a case of acute lymphoblastic leukemia (ALL) with t(4;11) (q21;q23) occurring 9 months after treatment of osteogenic sarcoma. Cell surface marker and molecular analyses suggest early B lineage involvement. This is the first report, to the knowledge of the authors, of t(4;11) ALL arising after an osteogenic sarcoma. The observations of the authors support the possibility of a causal relationship between exposure to carcinogens and the occurrence of leukemia with t(4;11).
Kapelushnik
J
J
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Dubé
I
I
Wilson
P
P
Greenberg
M
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D012516:Osteosarcoma / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D013977:Tibia; D014178:Translocation, Genetic / Q000235:genetics*