Structure of the endolymphatic sac after instillation of hyaluronan in the middle ear.
Hyaluronan (HA) 0.5, 1, 1.9 and 4% was instilled into the round window niche in mice. Six hours after the 1.9% HA and 4, 6 and 8 h after the 4% HA deposition there was a significant increase in the proportion of granule-containing light epithelial cells in the endolymphatic sac. This indicated an increase in secretory activity. This activity could be a response to lowered intralabyrinthine pressure due to the osmotic capacity of HA. Secretion of high molecular substances can serve to keep the sac lumen patent and/or to regulate labyrinthine volume and pressure.
Jansson
B
B
Department of Otolaryngology, University Hospital, Uppsala, Sweden.
Friberg
U
U
Rask-Andersen
H
H
D000818:Animals; D004432:Ear, Middle / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure; D004712:Endolymphatic Sac / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008575:Meniere Disease / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008854:Microscopy, Electron
D006820:Hyaluronic Acid