The configuration of mitiromycin and its derivation from mitomycin B.
The configuration of mitiromycin (2) was first determined by NMR experiments including the NOE technique. The absolute structure of 2 was related to mitomycin B (3) because 2 was derived from 3 under basic conditions. The ketonic form 4 was presumed to be involved in the generation of 2.
Kono
M
M
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
Kasai
M
M
Shirahata
K
K
Hirayama
N
N
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008937:Mitomycins / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; C068816:mitiromycin; C046000:mitomycin A