title: Apomorphine is a potent inhibitor of type 2A protein phosphatase in rat brain.
abstract: Effects of five kinds of dopamine agonists on the activity of type 2A protein phosphatase in rat brain were studied. Apomorphine and SKF-38393 reduced the enzyme activity considerably and their effects were further enhanced in the presence of 10 microM Mn2+. Also, 6,7-ADTN slightly inhibited the activity. The present results suggest that type 2A protein phosphatase in the brain is possibly involved in dopamine mediated protein phosphorylation functions.
authors.affiliation: Laboratory of Biology, Osaka Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kawai
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors*; D010766:Phosphorylation; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000097847:Protein Phosphatase Inhibitory Proteins
chemical_list: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001058:Apomorphine; D010750:Phosphoproteins; D011506:Proteins; C024833:protein phosphatase inhibitor-2; D000097847:Protein Phosphatase Inhibitory Proteins