Hypoxia and local tumour control. Part 2.
The failure so far of the clinical effort to exploit laboratory knowledge as to the importance of hypoxia as a cause for radiation failure may have been the pursuit of this approach in isolation from other causes for radioresistance. In particular a capacity for rapid repopulation may be shown by a tumour showing resistance due to hypoxia. A knowledge of all the factors affecting radiosensitivity is required before the rational testing of hypoxic cell sensitisers can be planned.
Dische
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Marie Curie Research Wing, Regional Centre for Radiotherapy and Oncology, Mount Vernon Hospital, Northwood, Middlesex, U.K.
D015687:Cell Hypoxia / Q000528:radiation effects*; D003131:Combined Modality Therapy; D006801:Humans; D008920:Misonidazole / Q000627:therapeutic use; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*
D008920:Misonidazole