Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.
The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.
Serour
F
F
Department of Thoracic Surgery, Sheba Medical Center, Tel Hashomer, Israel.
Dan
M
M
Gorea
A
A
Yellin
A
A
Lieberman
Y
Y
Berger
S A
SA
D000284:Administration, Oral; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D015242:Ofloxacin