title: Infectious crystalline keratopathy. Role of nutritionally variant streptococci and other bacterial factors.
abstract: Infectious crystalline keratopathy (ICK) is a chronic corneal infection characterized by interlamellar plaques of gram-positive coccal bacteria in the absence of inflammatory cells. It generally occurs within a corneal graft. Viridans streptococci are usually isolated, but the clinical response to antibiotics is poor and disparate with the in vitro antimicrobial sensitivities. These features suggest the possibility of unusual bacterial factors in pathogenesis. Four cases caused by nutritionally variant viridans streptococci are described. The organisms were fully characterized. They have a rare nutritional requirement for pyridoxal and require defined culture conditions and specific identification. Nutritional variant streptococci (NVS) are principally described as causing endocarditis, another infection involving an avascular collagenous tissue, and exhibiting similar biologic behavior. Electronmicrographic evidence is also adduced that suggests the possible importance of intracorneal glycocalyx deposition. Such factors might explain the anomalous clinical characteristics of this condition.
authors.affiliation: Eye Research Institute, Boston, MA 02114.
authors.forename: L D
authors.initials: LD
authors.lastname: Ormerod
authors.forename: K L
authors.initials: KL
authors.lastname: Ruoff
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: P J
authors.initials: PJ
authors.lastname: Wasson
authors.forename: J C
authors.initials: JC
authors.lastname: Kintner
authors.forename: S P
authors.initials: SP
authors.lastname: Dunn
authors.forename: J H
authors.initials: JH
authors.lastname: Lass
authors.forename: I
authors.initials: I
authors.lastname: van de Rijn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D003316:Corneal Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D011730:Pyridoxal / Q000378:metabolism; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D013291:Streptococcus / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D011730:Pyridoxal