Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity.
Oct-1 and a second, previously unidentified octamer-binding protein (Oct-R) have been identified in extracts of Xenopus laevis oocytes and embryos. Oct-1 does not bind to the octamer motif associated with certain Xenopus laevis histone H2B gene promoters, whereas Oct-R binds well to this motif, but only in the sequence context of the H2B gene promoter.
Smith
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Department of Biological Sciences, University of Warwick, Coventry, UK.
Old
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001667:Binding, Competitive; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006657:Histones / Q000235:genetics*; D051863:Host Cell Factor C1; D051379:Mice; D008969:Molecular Sequence Data; D050811:Octamer Transcription Factor-1; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000378:metabolism*; D029867:Xenopus Proteins; D014982:Xenopus laevis
D004268:DNA-Binding Proteins; C497693:Hcfc1 protein, mouse; D006657:Histones; D051863:Host Cell Factor C1; C068351:Oct-R protein, Xenopus; D050811:Octamer Transcription Factor-1; C494169:POU2F1 protein, Xenopus; C494166:Pou2f1 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins