Time course changes in glycogen accretion, 6-phosphogluconate, fructose-2,6-bisphosphate, and lipogenesis upon refeeding a high sucrose diet to starved rats.
1. Starved rats refed 60% sucrose diets were used to determine in vivo lipogenesis and levels of hepatic metabolites. 2. Fatty acid synthesis increased 11-fold 4 hr after refeeding. 3. Glycogen rose from 3 to 100 mg/g liver after 8 hr. 4. Fructose-2,6-bisphosphate rose to 6 nmol/g at 1 hr and remained constant. 5. 6-Phosphogluconate increased from 10 to 45 nmol/g liver after 2 hr and remained constant.
Carmona
A
A
Department of Physiological Sciences, School of Veterinary Medicine, University of California-Davis 95616.
Nishina
P M
PM
Avery
E H
EH
Freedland
R A
RA
D000818:Animals; D004032:Diet; D005260:Female; D005635:Fructosediphosphates / Q000378:metabolism; D005942:Gluconates / Q000378:metabolism; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D013395:Sucrose / Q000008:administration & dosage
D005635:Fructosediphosphates; D005942:Gluconates; D008055:Lipids; D008112:Liver Glycogen; D013395:Sucrose; C027652:fructose 2,6-diphosphate; C008884:6-phosphogluconic acid