title: Nucleotide sequence of a Guinea-Bissau-derived human immunodeficiency virus type 2 proviral clone (HIV-2CAM2).
abstract: We report the complete nucleotide sequence of a human immunodeficiency virus type 2 (HIV-2) isolate from Guinea-Bissau (HIV-2CAM2). The genomic organization of HIV-2CAM2 is identical to that of other HIV-2 isolates but contains a stop codon in the pol gene. The deduced amino acid sequences of the viral proteins show variation of 20% in the gag, pol and vpx regions, and 25 to 45% in the tat, env and nef regions when compared to other isolates of HIV-2. This is greater than the variation observed between isolates of HIV-1.
authors.affiliation: Department of Haematology, University of Cambridge Clinical School, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Tristem
authors.forename: F
authors.initials: F
authors.lastname: Hill
authors.forename: A
authors.initials: A
authors.lastname: Karpas
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry*; D006169:Guinea-Bissau; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011533:Proviruses / Q000235:genetics*; D012191:Retroviridae Proteins / Q000235:genetics
chemical_list: D003062:Codon; D004279:DNA, Viral; D012191:Retroviridae Proteins