Strain differences in dietary hyperphagia: interactions with age and experience.
The development of susceptibility to dietary hyperphagia was examined in two strains of rats. Juvenile Lewis and CD rats fed a wet diet initially eat less energy than do rats fed the same diet in dry form. As the rats approach adulthood, rats fed the wet diet consume more energy than rats fed the dry diet. Lewis rats began displaying hyperphagia at an earlier age than did CD rats. However, Lewis rats, unlike CD rats, fed dry diet during the juvenile stage and subsequently switched to wet diets, displayed only transient hyperphagia. Variability between animals within a group was substantially smaller in Lewis than in CD rats, indicating that genetic factors may be responsible for the differences between the two strains. Thus, susceptibility to dietary hyperphagia is influenced by interactions between strain of rat, age of testing, and type of diet fed in the juvenile stage.
Ramirez
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Monell Chemical Senses Center, Philadelphia, PA 19104-3308.
D000375:Aging / Q000523:psychology*; D000818:Animals; D001835:Body Weight / Q000235:genetics; D004435:Eating / Q000235:genetics*; D005260:Female; D011939:Mental Recall; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013649:Taste / Q000235:genetics*