title: Antitumor activity of quassinoids from Hannoa klaineana.
abstract: Of the five quassinoids isolated from the root bark of Hannoa klaineana, only 15-desacetylundulatone was found active against P388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma. Undulatone and especially 15-O-beta-D-glucopyranosyl-21-hydroxy-glaucarubolone were found to be more toxic while 6 alpha-tigloyloxy-glaucarubol and 21-hydroxyglaucarubolone were found inactive. Structure-activity relationships are discussed.
authors.affiliation: Institut de Recherche Sciences de la Santé, Kinshasa-Gombe, Zaire.
authors.forename: L
authors.initials: L
authors.lastname: Lumonadio
authors.forename: G
authors.initials: G
authors.lastname: Atassi
authors.forename: M
authors.initials: M
authors.lastname: Vanhaelen
authors.forename: R
authors.initials: R
authors.lastname: Vanhaelen-Fastre
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts