1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.
Weinstock
J
J
Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
Keenan
R M
RM
Samanen
J
J
Hempel
J
J
Finkelstein
J A
JA
Franz
R G
RG
Gaitanopoulos
D E
DE
Girard
G R
GR
Gleason
J G
JG
Hill
D T
DT
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008968:Molecular Conformation; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes; D014661:Vasoconstriction / Q000187:drug effects*
D000179:Acrylates; D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D007202:Indicators and Reagents; D011945:Receptors, Angiotensin; D013876:Thiophenes; D000804:Angiotensin II; C068373:eprosartan