title: Meningeal involvement in Bence Jones multiple myeloma.
abstract: A case of Bence Jones kappa multiple myeloma with meningeal involvement in a 64-year-old woman is presented. Three years after the diagnosis of multiple myeloma, gait disturbances developed followed by visual disorders and impaired consciousness. A lumbar puncture revealed numerous atypical plasma cells in the cerebrospinal fluid. Craniospinal irradiation and intrathecal injections of methotrexate, cytarabine, and prednisolone were effective for a short period. At autopsy, the leptomeninges were infiltrated diffusely with atypical plasma cells. A review of the literature showed that multiple myeloma with meningeal involvement is accompanied frequently by circulating atypical plasma cells or plasma cell leukemia. Meningeal involvement is a rare complication and shows poor prognosis in cases of multiple myeloma.
authors.affiliation: Department of Internal Medicine, Hiroshima City Asa Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Egawa
authors.forename: T
authors.initials: T
authors.lastname: Okuhara
authors.forename: A
authors.initials: A
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Hyohdou
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Kuramoto
mesh_terms: D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000134:cerebrospinal fluid / Q000150:complications* / Q000473:pathology