Stroke in a young adult with Fletcher trait.
We have reported the case of a young woman with prekallikrein deficiency who had a cerebral infarction despite a prolonged APTT. She had bleeding complications with heparin administration. From the limited information in the literature, anticoagulation may be hazardous in these patients, and it should be undertaken with caution.
Hess
D C
DC
Department of Neurology, Medical College of Georgia, Augusta 30912.
Krauss
J S
JS
Rardin
D
D
D000328:Adult; D002544:Cerebral Infarction / Q000097:blood* / Q000175:diagnosis; D000075202:Contraindications; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008595:Menorrhagia / Q000139:chemically induced; D010314:Partial Thromboplastin Time; D011288:Prekallikrein / Q000172:deficiency*
D006493:Heparin; D011288:Prekallikrein