title: Altered acceptability of and preference for sugar solutions by diabetic rats is normalized by high-fat diet.
abstract: Two experiments examined the ingestive responses of streptozotocin-diabetic rats fed low-fat or high-fat diets to glucose, fructose, sucrose and maltose solutions in brief (30 min) intake tests. In Experiment 1, one-bottle acceptability tests were used whereas two-bottle preference tests were used in Experiment 2. Three main findings resulted from these studies. Firstly, diabetic rats fed the low-fat diet displayed a reduced acceptance of and preference for all concentrated sugar solutions. Secondly, glucose consumption patterns of diabetic rats fed the low-fat diet were distinctly different from their responses to the other sugars. Thirdly feeding high-fat diets, either high or low in carbohydrate, normalized the responses of diabetic rats to the sugar solutions. The results suggest that feeding high-fat diets to diabetic rats normalizes their responses to sugar solutions because of reductions in hunger and thirst associated with the provision of a utilizable source of calories and an improvement in body fluid balance.
authors.affiliation: Monell Chemical Senses Center, Philadelphia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Tepper
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004326:Drinking; D005518:Food Preferences; D005632:Fructose / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D008320:Maltose / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013395:Sucrose / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D012996:Solutions; D005632:Fructose; D013395:Sucrose; D008320:Maltose; D005947:Glucose