Maduropeptin, a complex of new macromolecular antitumor antibiotics.
Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.
Hanada
M
M
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Ohkuma
H
H
Yonemoto
T
T
Tomita
K
K
Ohbayashi
M
M
Kamei
H
H
Miyaki
T
T
Konishi
M
M
Kawaguchi
H
H
Forenza
S
S
D000190:Actinomyces / Q000378:metabolism; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D053281:Enediynes; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008970:Molecular Weight; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use; D010777:Photochemistry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D023181:Antimicrobial Cationic Peptides; D053281:Enediynes; D010455:Peptides; C075998:maduropeptin A1; C075999:maduropeptin A2; C076000:maduropeptin B; C076002:maduropeptin C