Poisoning induced by administration of a phosphate-containing urinary acidifier in a cat.
Signs of depression, hyperphosphatemia, azotemia, high anion gap metabolic acidosis, and renal failure developed in an adult cat following administration of an excessive dose of a phosphate-containing urinary acidifier. After extracellular fluid volume expansion, diuresis, and administration of a phosphate binder, serum phosphorus concentration returned to normal in 12 hours; the cat recovered fully. The urinary acidifier had been given as part of treatment for a urinary tract infection. Findings suggest that phosphate-containing urinary acidifiers should be administered cautiously because, like other sources of phosphate, they are capable of causing life-threatening metabolic disturbances.
Fulton
R B
RB
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Fruechte
L K
LK
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000139:chemically induced / Q000662:veterinary; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000097:blood; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002415:Cats; D003404:Creatinine / Q000097:blood; D005260:Female; D010710:Phosphates / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D011041:Poisoning / Q000662:veterinary; D012709:Serum Albumin / Q000032:analysis; D014511:Uremia / Q000139:chemically induced / Q000662:veterinary; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000662:veterinary*
D010710:Phosphates; D012709:Serum Albumin; D003404:Creatinine; D002118:Calcium