title: Effect of pericardium on left ventricular early filling assessed by pulsed Doppler echocardiography.
abstract: Pericardial effect on left ventricular early filling was studied in six dogs by use of pulsed Doppler echocardiography. Rapid dextran infusion was used to manipulate left atrial pressure. Left ventricular peak early filling velocities before and after pericardiectomy were measured at different levels of left atrial pressure with right atrial and left ventricular pressures. Peak early filling velocity correlated with mean left atrial pressure before and after pericardiectomy. Before pericardiectomy, when mean right atrial pressure exceeded 12 mm Hg, further increase of the velocity was not observed in spite of volume loading. After pericardiectomy, peak early filling velocity became higher and the slope of the relation line between mean left atrial pressure and the velocity became steeper than before pericardiectomy. When the filling pressure was denoted by the transmural mean left atrial pressure, the points on the relation line before pericardiectomy fell along the relation line after pericardiectomy. We conclude the pericardium exerts an external constraint on left ventricular early filling. Therefore we should not consider the absolute but the transmural filling pressure when estimating left ventricular early diastolic function with use of Doppler-derived left ventricular early filling velocity.
authors.affiliation: National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakatani
authors.forename: S
authors.initials: S
authors.lastname: Beppu
authors.forename: K
authors.initials: K
authors.lastname: Miyatake
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
mesh_terms: D000818:Animals; D016279:Atrial Function, Left; D004285:Dogs; D015150:Echocardiography, Doppler; D010492:Pericardiectomy; D010496:Pericardium / Q000502:physiology*; D016277:Ventricular Function, Left