Evaluation of nitrendipine--a new calcium channel blocker.
Nitrendipine (Baypress; Bayer-Miles), a new calcium channel blocker, was administered to 38 hypertensive patients in an oral dose of 20 mg once or twice daily. Both systolic and diastolic blood pressures were reduced to a clinically relevant extent within 2 hours of taking the medication. There was no loss of effect during the 57 days of the trial. No significant changes in heart rate were noted. On the whole, side-effects were mild and transient and consisted mainly of dizziness, headache, joint pains and oedema.
Rossouw
D S
DS
Department of Internal Medicine, University of Pretoria.
Luus
H G
HG
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009568:Nitrendipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects
D009568:Nitrendipine