Genotoxic and cell-transforming properties of (trans,trans)-muconaldehyde.
(trans,trans)-Muconaldehyde, a putative metabolite of benzene, should be expected to have mutagenic properties by virtue of its twin alpha,beta-unsaturated carbonylic function. It displayed definitely mutagenic properties in S. typhimurium TA100 without metabolic activation and with a 5-fold concentration of tester organisms in the preincubation assay and induced SOS response in E. coli. It induced micronucleus formation and morphological transformation in a dose-dependent manner in Syrian hamster embryofibroblasts. No DNA single-strand breaks or interstrand cross-links could be detected using the alkaline elution technique; however, strand-break generation by subsequent gamma-irradiation was found to be increased.
Henschler
D
D
Institute of Pharmacology and Toxicology, University of Würzburg, F.R.G.
Eder
E
E
Epe
B
B
Schiffmann
D
D
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006224:Cricetinae; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D066298:In Vitro Techniques; D051379:Mice; D048629:Micronuclei, Chromosome-Defective; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000447:Aldehydes; C034476:muconaldehyde; D004247:DNA