Teratogenic effect of cocaine and diazepam in CF1 mice.
This study was conducted to determine the teratogenic effect of cocaine hydrochloride, alone or in combination with diazepam. Pregnant mice were administered cocaine hydrochloride at 10 and 20 mg/kg body weight intravenously (tail), and/or diazepam at 20 or 40 mg/kg b.w. by gavage. Combinations of diazepam and cocaine (20/10 and 40/20, respectively) were used. Significant reductions of fetal weight and length were found in the group treated with diazepam and cocaine (40/20). The incidences of incomplete ossification of sternebrae and skull bones, as well as delayed ossification of the paws, were significantly increased in the combination groups. Hydronephrosis and cryptorchidism were observed in the cocaine-treated groups, with the incidence of these malformations increasing significantly when diazepam was co-administered.
Mehanny
S Z
SZ
Department of Pharmacology and Toxicology, New Jersey Medical School, Newark 07103.
Abdel-Rahman
M S
MS
Ahmed
Y Y
YY
D000014:Abnormalities, Drug-Induced; D000704:Analysis of Variance; D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D003975:Diazepam / Q000633:toxicity*; D004347:Drug Interactions; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005313:Fetal Death; D005327:Fetal Resorption; D005333:Fetus / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D012016:Reference Values; D013723:Teratogens
D013723:Teratogens; D003042:Cocaine; D003975:Diazepam