Lack of protective effect of thromboxane synthetase inhibitor (CGS-13080) on single dose radiated canine intestine.
The effect of a thromboxane A2 synthetase inhibitor (CGS-13080) on canine intestine was studied using a single dose of radiation, and radioactive microspheres were used to determine resultant blood flow. Thromboxane A2 causes vasospasm and platelet aggregation and may play a dominant role in radiation injury. However, there was no effect on the intestinal blood flow diminution occurring after radiation in this laboratory model using this thromboxane A2 synthetase inhibitor.
Barter
J F
JF
Division of Gynecologic Oncology, Georgetown University Medical Center, Washington, D.C. 2007.
Marlow
D
D
Kamath
R K
RK
Harbert
J
J
Torrisi
J R
JR
Barnes
W A
WA
Potkul
R K
RK
Newsome
J T
JT
Delgado
G
G
D000818:Animals; D002588:Cesium Radioisotopes / Q000009:adverse effects; D004285:Dogs; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D007422:Intestines / Q000098:blood supply / Q000187:drug effects / Q000528:radiation effects*; D011725:Pyridines / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D012039:Regional Blood Flow / Q000187:drug effects / Q000528:radiation effects; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D002588:Cesium Radioisotopes; D007093:Imidazoles; D011725:Pyridines; D011837:Radiation-Protective Agents; C037787:pirmagrel; D013930:Thromboxane-A Synthase