title: Optic neuritis and orbital lesions: lipid-suppressed chemical shift MR imaging.
abstract: A derivative of the Dixon method, chopper fat suppression, was used in the magnetic resonance imaging evaluation of 40 patients: 37 with suspected optic nerve lesions, predominantly optic neuritis, and three with orbital lesions. In patients with optic neuritis, the technique was sensitive, allowing detection of 29 of 34 visual-evoked-response-confirmed lesions on T2-weighted lipid-suppressed images. There were no false-positive studies. Sensitivity for detection of optic neuritis was 89%; specificity, 100%; and accuracy, 86%. The technique was also useful for depicting inflammatory changes in the orbital apex due to fungal abscess and confirming the fatty nature of an extraconal dermoid tumor. A slight increase in noise and mild accentuation of susceptibility effects at interfaces of air, bone, and brain did not degrade images significantly. The chopper-based technique requires only standard imaging time and has usual spin-echo sensitivity. The results are comparable to short-inversion-time inversion-recovery imaging, without the constraints of sequence limitations or artifacts at fat and water interfaces.
authors.affiliation: Departments of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Szumowski
authors.forename: T E
authors.initials: TE
authors.lastname: Feasby
authors.forename: S J
authors.initials: SJ
authors.lastname: Karlik
authors.forename: A J
authors.initials: AJ
authors.lastname: Fox
authors.forename: D M
authors.initials: DM
authors.lastname: Pelz
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D005074:Evoked Potentials, Visual; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009902:Optic Neuritis / Q000175:diagnosis*; D009916:Orbital Diseases / Q000175:diagnosis*; D012680:Sensitivity and Specificity