title: A vascular network closely linked to the epithelium of the urinary bladder of the rat.
abstract: Scanning electron microscopy was used on the mucosa of the rat urinary bladder after digestion with strong alkali and microdissection. The underside of the epithelium (and the plane of the epithelium-tunica propria interface) is not smooth but is scored by grooves--10 microns wide and 3-4 microns deep--connected into a fine mesh. A net of blood capillaries located in the uppermost part of the tunica propria occupies these grooves. They measure 3-9 microns in diameter, are separated from the epithelium by a gap of 0.3 micron, often show fenestrations, and are accompanied by numerous and extensive pericytes and by some fibroblasts. We discuss these observations in the light of current knowledge of blood flow in the bladder, contraction and distension of the bladder wall and formation of mucosal folds, transport of solutes through the epithelium, and plasma extravasation from mucosal blood vessels in neurogenic inflammation.
authors.affiliation: Department of Anatomy, University College London, Great Britain.
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: G
authors.initials: G
authors.lastname: Gabella
mesh_terms: D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D004848:Epithelium / Q000098:blood supply / Q000648:ultrastructure; D005260:Female; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000098:blood supply* / Q000648:ultrastructure