title: The discriminative stimulus effect of MK-801 in ketamine-trained rats.
abstract: MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate] was assessed for its discriminative stimulus properties in rats trained to discriminate ketamine (7 mg/kg) from vehicle. MK-801 generalized to ketamine in a dose dependent manner with a maximum effect at 0.2 mg/kg, while ketamine generalized fully at 10 mg/kg. These results indicate that ketamine and MK-801 may share a common mechanism of action, which is related to the phencyclidine recognition site in the brain.
authors.affiliation: Department of Pharmacology, Anaquest/BOC Health Care, Murray Hill, NJ 07974.
authors.forename: M J
authors.initials: MJ
authors.lastname: Benvenga
authors.forename: A V
authors.initials: AV
authors.lastname: Wing
authors.forename: R A
authors.initials: RA
authors.lastname: Del Vecchio
mesh_terms: D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007649:Ketamine; D016291:Dizocilpine Maleate