A bilayer "artificial skin" capable of sustained release of an antibiotic.
The most frequent complication of the bilayer "artificial skin", composed of a silicone sheet and collagen sponge described in a previous paper, was infection beneath it. This paper describes a new type of "artificial skin" in which microspheres containing antibiotics were installed beneath the silicone sheet, allowing a continuous release of antibiotics.
Matsuda
K
K
Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
Suzuki
S
S
Isshiki
N
N
Yoshioka
K
K
Okada
T
T
Hyon
S H
SH
Ikada
Y
Y
D000328:Adult; D001187:Artificial Organs; D001672:Biocompatible Materials; D003094:Collagen; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008863:Microspheres; D012867:Skin; D016038:Skin Transplantation; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003094:Collagen; D014031:Tobramycin