Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use.
Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.
Nunes
E V
EV
Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.
Quitkin
F M
FM
Brady
R
R
Stewart
J W
JW
D000328:Adult; D003042:Cocaine; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006556:Heroin Dependence / Q000188:drug therapy / Q000534:rehabilitation; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D010865:Pilot Projects; D015819:Substance Abuse, Intravenous / Q000188:drug therapy / Q000534:rehabilitation; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000534:rehabilitation
D003042:Cocaine; D007099:Imipramine; D008691:Methadone