Bambuterol: a new long acting bronchodilating prodrug.
Bambuterol, a carbamate prodrug of terbutaline as a 5, 10, or 20-mg tablet, was given once every evening to patients with asthma in a randomized double-blind crossover study. Twenty milligrams improved pulmonary functions over 24 hours; 5 and 10 mg did not. Few side effects were observed.
Vilsvik
J S
JS
Department of Pulmonary Disease, Regional Hospital, University of Trondheim, Norway.
Langaker
O
O
Persson
G
G
Ringdal
N
N
Schaanning
J
J
Kvelstad
G
G
Svensson
K
K
Holthe
S
S
Soliman
S
S
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects / Q000502:physiology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013726:Terbutaline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001993:Bronchodilator Agents; D013726:Terbutaline; C047766:bambuterol