Gravidin, an endogenous inhibitor of phospholipase A2 activity, is a secretory component of IgA.
Gravidin, a phospholipase inhibitor characterised previously from amniotic fluid, was partially sequenced at the N-terminal and found to be identical to secretory component of human IgA. Inhibition of antiphospholipase activity was observed after incubation of gravidin with monoclonal antibody to human secretory component. Secretory component isolated from human saliva and breast milk was found to inhibit arachidonic acid release from human lymphocytes. It was concluded that gravidin is secretory component of IgA.
Wilson
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T
Dept. of Cellular and Molecular Biology, University of Auckland, New Zealand.
Christie
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DL
D000595:Amino Acid Sequence; D000653:Amniotic Fluid / Q000737:chemistry; D001095:Arachidonic Acids / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000302:isolation & purification*; D066298:In Vitro Techniques; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008969:Molecular Sequence Data; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry
D001095:Arachidonic Acids; D007071:Immunoglobulin A, Secretory; D011257:Pregnancy Proteins; C058795:gravidin; D010741:Phospholipases A; D054467:Phospholipases A2