Alteration of cartilagenous proteoglycan in psoriasis.
Articular tissue was obtained at surgery for a femoral neck fracture in a patient with psoriasis without arthritis. The proteoglycan of the cartilage of the sample was analysed biochemically. Normal cartilage is known to produce two types of proteoglycan monomers (fast- and slow-sedimenting groups), which are distinguishable by density-gradient ultracentrifugation. In the psoriatic cartilage analysed in the present study, it was shown that the former group was absent and only the latter group remained.
Yutani
Y
Y
Department of Orthopaedic Surgery, Osaka City University Medical School, Japan.
Kono
T
T
Ishii
M
M
Chanoki
M
M
Chanoki
Y
Y
Asada
K
K
Shimazu
A
A
Hamada
T
T
D002358:Cartilage, Articular / Q000378:metabolism*; D046508:Culture Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism*; D013462:Sulfur Radioisotopes / Q000378:metabolism
D011509:Proteoglycans; D013462:Sulfur Radioisotopes