Soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin at delivery.
In this work we have quantified soluble class I histocompatibility antigens (s-HLA) and beta 2-microglobulin (beta 2 m) in sera of HIV+ or HIV- mothers at delivery and in cord blood sera of their newborn children. The results obtained for beta 2 m show that cord blood sera of newborn children have higher concentrations than their mothers, implying that most of the beta 2 m in the newborn is self-produced as described previously. s-HLA serum concentrations in the newborn children are significantly lower than in their mothers or in age-matched controls. Moreover, HIV+ mothers have significantly higher serum concentrations than HIV- mothers or an age-matched control group. These results suggest that s-HLA does not cross the placental barrier.
Ferreira
A
A
Immunology Unit, Hospital La Paz, Madrid Spain.
García Rodríguez
M C
MC
Omeñaca
F
F
Jiménez
A
A
Villar
L M
LM
Gonzalez-Porqué
P
P
Fontán
G
G
D005260:Female; D005312:Fetal Blood; D015658:HIV Infections / Q000097:blood*; D006679:HIV Seropositivity; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D001613:beta 2-Microglobulin / Q000378:metabolism*
D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin