title: Antibody responses of laboratory mice to sequential feedings by two species of argasid ticks (Acari: Argasidae).
abstract: The host antibody response of CD1 mice resulting from sequential exposures to two species of Ornithodoros ticks was isotyped (ELISA) in an effort to determine the mechanism for the development of acquired resistance. In addition, salivary gland proteins from two argasid and one ixodid species were examined (RIA) for cross-reactivity. Significant antibody responses, detectable for at least 90 d after last exposure, were shown to occur. Isotyping showed that the initial response was of the IgM class with a secondary class switch to the IgG1 subclass occurring. Evidence that cross-reactive proteins exist between argasid and ixodid ticks is also discussed.
authors.affiliation: Department of Entomology and Nematology, University of Florida, Gainesville 32611.
authors.forename: J T
authors.initials: JT
authors.lastname: Need
authors.forename: J F
authors.initials: JF
authors.lastname: Butler
authors.forename: S G
authors.initials: SG
authors.lastname: Zam
authors.forename: E J
authors.initials: EJ
authors.lastname: Wozniak
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003429:Cross Reactions; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D051379:Mice; D011863:Radioimmunoassay; D013984:Tick Infestations / Q000276:immunology*; D013987:Ticks / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M