[Effect of the antioxidant dibunol on the hormonal status of adult and old rats].
The effect of chronic administration of antioxidant dibunol (BHT) on the blood level of thyrotropin, corticotropin, thyroxin, triiodothyronine, 11-hydroxycorticosteroids, immunoreactive insulin and the reactivity of isolated thyroids and adrenals to tropic hormones were studied in adult and old male rats. Chronic administration of BHT was found to inhibit the thyroid functional activity of both animal groups and to reduce the blood insulin level in the old rats. The results obtained suggest that hormonal effects play an essential role in the mechanism of BHT action on the organism.
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D000302:Adrenal Cortex / Q000187:drug effects; D000375:Aging / Q000097:blood*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects; D013997:Time Factors
D000975:Antioxidants; D006728:Hormones; D007328:Insulin; D002084:Butylated Hydroxytoluene