[Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine].
Side effects in general and in particular to antiinfective therapy are obviously hardly predictable and a causal relationship is seldom firmly established. The handling of untoward reactions may be improved if a subpopulation which can be identified is at particular risk for a given reaction. A clear assessment of dose and time dependency of untoward reactions is important in this context. Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk.
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Medizinische Klinik, Zieglerspital, Bern, Switzerland.
Neftel
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KA
D000380:Agranulocytosis / Q000139:chemically induced*; D000655:Amodiaquine / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced*; D014640:Vancomycin / Q000009:adverse effects*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000655:Amodiaquine; D014640:Vancomycin