title: Structure of the endolymphatic sac after instillation of hyaluronan in the middle ear.
abstract: Hyaluronan (HA) 0.5, 1, 1.9 and 4% was instilled into the round window niche in mice. Six hours after the 1.9% HA and 4, 6 and 8 h after the 4% HA deposition there was a significant increase in the proportion of granule-containing light epithelial cells in the endolymphatic sac. This indicated an increase in secretory activity. This activity could be a response to lowered intralabyrinthine pressure due to the osmotic capacity of HA. Secretion of high molecular substances can serve to keep the sac lumen patent and/or to regulate labyrinthine volume and pressure.
authors.affiliation: Department of Otolaryngology, University Hospital, Uppsala, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Jansson
authors.forename: U
authors.initials: U
authors.lastname: Friberg
authors.forename: H
authors.initials: H
authors.lastname: Rask-Andersen
mesh_terms: D000818:Animals; D004432:Ear, Middle / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure; D004712:Endolymphatic Sac / Q000187:drug effects* / Q000503:physiopathology / Q000648:ultrastructure; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008575:Meniere Disease / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008854:Microscopy, Electron
chemical_list: D006820:Hyaluronic Acid