title: Cytoprotective activity of pectic polysaccharides from the root of panax ginseng.
abstract: An acidic polysaccharide fraction, GRA-4, of the root extract of Panax ginseng, when administered from 50 to 200 mg/kg orally, inhibited gastric lesions induced by HCl-ethanol or absolute ethanol, in a dose-dependent manner. The cytoprotective activity of GRA-4 decreased after its treatment with periodate but not after protein digestion, indicating that the carbohydrate moiety of this acidic polysaccharide contributes to this activity.
authors.affiliation: Oriental Medicine Research Center, Kitasato Institute, Tokyo, Japan.
authors.forename: X B
authors.initials: XB
authors.lastname: Sun
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Kiyohara
authors.forename: M
authors.initials: M
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D005894:Panax; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D011134:Polysaccharides; D000431:Ethanol