Ability of ceftibuten to induce the class-I beta-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes.
Ceftibuten, like cefotaxime, was observed to be a weak inducer of the class-I beta-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes. In contrast, cefoxitin and imipenem induced these enzymes strongly at subinhibitory concentrations.
Papanicolaou
G A
GA
Division of Infectious Diseases, Miriam Hospital, Providence, RI 02906.
Medeiros
A A
AA
D002439:Cefotaxime / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D000077722:Ceftibuten; D002511:Cephalosporins / Q000494:pharmacology*; D004754:Enterobacter / Q000187:drug effects* / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis*
D002511:Cephalosporins; D002440:Cefoxitin; D015378:Imipenem; D001618:beta-Lactamases; D000077722:Ceftibuten; D002439:Cefotaxime