Novel antibiotics, furaquinocins C, D, E, F, G and H.
Furaquinocins C, D, E, F, G and H, congeners of furaquinocins A and B, were isolated from the culture broth of Streptomyces sp. KO-3988 and their structures have been determined on the basis of their spectroscopical and chemical properties. These antibiotics showed cytocidal activities against HeLa S3 and B16 melanoma cells in vitro.
Ishibashi
M
M
Kitasato Institute, Kitasato University, Tokyo, Japan.
Funayama
S
S
Anraku
Y
Y
Komiyama
K
K
Omura
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000473:pathology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C068887:furaquinocin C; C068888:furaquinocin D; C068889:furaquinocin E; C068890:furaquinocin F; C068891:furaquinocin G; C068892:furaquinocin H