Transcriptional suppression of cellular gene expression by c-Myc.
High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.
Yang
B S
BS
Molecular Biology Research Program, Henry Ford Hospital, Detroit, Michigan 48202.
Geddes
T J
TJ
Pogulis
R J
RJ
de Crombrugghe
B
B
Freytag
S O
SO
D000818:Animals; D002460:Cell Line; D003094:Collagen / Q000235:genetics*; D015870:Gene Expression; D016259:Genes, myc; D016350:Leucine Zippers; D051379:Mice; D011401:Promoter Regions, Genetic; D013489:Suppression, Genetic; D014158:Transcription, Genetic
D003094:Collagen