Calcitonin gene-related peptide promotes transient radiocalcium uptake into chick bone in vivo.
We have examined the in vivo effects in chicks of intravenously injected chicken (c-) and rat (r-) calcitonin gene-related peptides (CGRP) on uptake into bone of a simultaneously administered 45Ca label. Both peptides caused transient (10 min) increases in 45Ca uptake into a variety of bone types. In dose-response experiments at 10 min, CGRP doses of 0.26-1.04 nmol/100 g body wt were found to give maximal responses. These were well developed in chicks fasted for 22 h but absent in those which were continuously fed. This contrasts with the hypercalcaemic effect of CGRP which is apparent in fed rather than fasted chicks.
Ancill
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AK
Division of Pharmacology, School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic.
Bascal
Z A
ZA
Whitaker
G
G
Dacke
C G
CG
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female
D015740:Calcitonin Gene-Related Peptide; D002118:Calcium