Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay.
The nitrosourea mustard MeCCNU is the most recent organic chemical to be classified as a human carcinogen by IARC. MeCCNU gave a strong positive response when tested in the mouse bone marrow micronucleus assay. Activity was evident using either ip injection or oral gavage of the test chemical. These results further support the correlation between human carcinogens and their genotoxicity.
Tinwell
H
H
ICI Central Toxicology Laboratory, Alderley Park Macclesfield, Cheshire, United Kingdom.
Ashby
J
J
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D015394:Molecular Structure; D012673:Semustine / Q000633:toxicity*
D002273:Carcinogens; D012673:Semustine