title: Hyperacute rejection in heart allografts. Case studies.
abstract: Hyperacute rejection in orthotopic heart allografts is a rare event. In our material from a total collective of 524 heart-transplanted patients, we have observed two cases of hyperacute rejection, which are presented in this case report. Histopathologically, this entity is characterized above all by the following triad: pronounced edema, hemorrhages, and regressive changes up to necroses of myocytes. Besides the well-known risk factors, our report draws attention to two further factors possibly associated with an increased risk of hyperacute rejection: 1) repeated cardiac surgery prior to the transplantation, and 2) presence of identical viral genomes in recipient's and donor's heart.
authors.affiliation: Institute of Pathology, Hannover Medical School, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Kemnitz
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: I
authors.initials: I
authors.lastname: Restrepo-Specht
authors.forename: A
authors.initials: A
authors.lastname: Haverich
authors.forename: G
authors.initials: G
authors.lastname: Ziemer
authors.forename: B
authors.initials: B
authors.lastname: Heublein
authors.forename: H G
authors.initials: HG
authors.lastname: Borst
authors.forename: A
authors.initials: A
authors.lastname: Uysal
authors.forename: A
authors.initials: A
authors.lastname: Georgii
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001344:Autopsy; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006084:Graft Rejection; D006321:Heart / Q000382:microbiology; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D012307:Risk Factors
chemical_list: D000936:Antigen-Antibody Complex; D004279:DNA, Viral