title: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease.
abstract: The Neuropathology Task Force of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) has developed a practical and standardized neuropathology protocol for the postmortem assessment of dementia and control subjects. The protocol provides neuropathologic definitions of such terms as "definite Alzheimer's disease" (AD), "probable AD," "possible AD," and "normal brain" to indicate levels of diagnostic certainty, reduce subjective interpretation, and assure common language. To pretest the protocol, neuropathologists from 15 participating centers entered information on autopsy brains from 142 demented patients clinically diagnosed as probable AD and on eight nondemented patients. Eighty-four percent of the dementia cases fulfilled CERAD neuropathologic criteria for definite AD. As increasingly large numbers of prospectively studied dementia and control subjects are autopsied, the CERAD neuropathology protocol will help to refine diagnostic criteria, assess overlapping pathology, and lead to a better understanding of early subclinical changes of AD and normal aging.
authors.affiliation: VA Medical Center, Department of Pathology and Laboratory Medicine, Decatur, GA 30033.
authors.forename: S S
authors.initials: SS
authors.lastname: Mirra
authors.forename: A
authors.initials: A
authors.lastname: Heyman
authors.forename: D
authors.initials: D
authors.lastname: McKeel
authors.forename: S M
authors.initials: SM
authors.lastname: Sumi
authors.forename: B J
authors.initials: BJ
authors.lastname: Crain
authors.forename: L M
authors.initials: LM
authors.lastname: Brownlee
authors.forename: F S
authors.initials: FS
authors.lastname: Vogel
authors.forename: J P
authors.initials: JP
authors.lastname: Hughes
authors.forename: G
authors.initials: G
authors.lastname: van Belle
authors.forename: L
authors.initials: L
authors.lastname: Berg
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002102:Cadaver; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D012016:Reference Values; D012042:Registries
chemical_list: D000682:Amyloid