Acyclovir-induced renal failure: course and risk factors.
Of 19 children treated with high-dose intravenous acyclovir, 7, all of whom had encephalitis, also had a restricted fluid intake. Of these, 3 experienced non-oliguric renal insufficiency (plasma creatinine up to 176, 250 and 351 mumol/l, respectively) which resolved within 1 week of discontinuing acyclovir. Renal function was stable in the remaining 4 patients in this group and in the 12 children treated with acyclovir but without fluid restriction. We suggest the decreased renal function resulted from intratubular acyclovir crystalluria.
Bianchetti
M G
MG
Department of Paediatrics, University Children's Hospital, Inselspital, Berne, Switzerland.
Roduit
C
C
Oetliker
O H
OH
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects*; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
D000212:Acyclovir