Comparison of production of volatile hydrocarbons by phenylhydrazine-induced peroxidation in rats chronically treated with lead.
We have studied the effect of a chronic pretreatment by lead on the peroxidation processes by measuring the production of the four main volatile hydrocarbons: ethane and pentane as index of lipid peroxidation; propane as marker of protein peroxidation and ethylene as index of both lipid and protein peroxidations. Our results have shown that: 1) lead alone did not increase the physiological formation of alkanes indicating that lead is not able per se to initiate the peroxidative processes; 2) after phenylhydrazine injection, lipid peroxidation makers were not modified, except pentane in male lead-treated rats. Conversely, ethylene and propane exhalation were increased 45 min after phenylhydrazine injection in lead-treated rats indicating a potentialisation of the oxidative effect of phenylhydrazine, mainly on proteins, by lead.
Hafi
A
A
Laboratoire de Toxicologie, Faculté de Pharmacie, Châtenay Malabry.
Cluet
J L
JL
Pages
N
N
Fournier
G
G
Alcindor
R
R
Boudene
C
C
D000818:Animals; D005260:Female; D006838:Hydrocarbons / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010545:Peroxides / Q000378:metabolism*; D010659:Phenylhydrazines / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D006838:Hydrocarbons; D010545:Peroxides; D010659:Phenylhydrazines; D011506:Proteins; C030299:phenylhydrazine; D007854:Lead