Naturally occurring benzodiazepines in human milk.
The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines. The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 +/- 0.74 ng in male plasma; to 2.20 +/- 0.35 ng in female plasma and to 1.91 +/- 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.
Peña
C
C
Instituto de Biología Celular, Facultad de Medicina, (UBA-CONICET), Buenos Aires, Argentina.
Medina
J H
JH
Piva
M
M
Diaz
L E
LE
Danilowicz
C
C
Paladini
A C
AC
D001569:Benzodiazepines / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy; D011869:Radioligand Assay; D012016:Reference Values
D001569:Benzodiazepines