Topical metronidazole in the treatment of perioral dermatitis.
The twice-daily topical application of 1% metroindazole cream was compared with 250 mg oral tetracycline, taken twice daily, in the treatment of perioral dermatitis in a prospective, double-blind, double-dummy, randomized, multicenter trial. One hundred eight patients were treated for 8 weeks. At the end of this time the median number of papules in the metronidazole-treated group was reduced to 8% of the initial number, and the median number in the group treated with tetracycline was reduced to 0% of the initial number. Although both treatments were effective, oral tetracycline was significantly more effective than topical metronidazole.
Veien
N K
NK
Dermatology Clinic, Aalborg, Denmark.
Munkvad
J M
JM
Nielsen
A O
AO
Niordson
A M
AM
Stahl
D
D
Thormann
J
J
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003872:Dermatitis / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004890:Erythema / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*; D011446:Prospective Studies; D013754:Tetracyclines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D013754:Tetracyclines; D008795:Metronidazole