Prenatal and postnatal consequences in the brain and behavior of rats exposed to ultrasound in utero.
As a result of a prior experiment demonstrating damage to the developing cortex of the fetal rat 24 hours after maternal exposure to ultrasound, postnatal consequences of similar exposure on rat behavior were examined. No decrease in postnatal weight or growth rate was found and no significant decrease in cortical thickness was present postnatally at 28 days. In two of four behavioral tests, rats exposed to ultrasound in utero resembled similarly treated controls. In one test, ultrasound-exposed rats showed slower performance, and in one, faster performance. These data provide no consistent evidence that ultrasound exposure resulted in deleterious postnatal effects.
Norton
S
S
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City 66103.
Kimler
B F
BF
Cytacki
E P
EP
Rosenthal
S J
SJ
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001522:Behavior, Animal; D001835:Body Weight; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D016216:Ultrasonography, Prenatal / Q000009:adverse effects*