title: Gender-related behavior development in females exposed to diethylstilbestrol (DES) in utero: an attempted replication.
abstract: This report concerns the role of prenatal hormones in normal and abnormal psychosexual differentiation. Several studies indicate that perinatal treatment of infrahuman female mammals with diethylstilbestrol (DES) masculinizes certain features of their brain and behavior. Accordingly, the authors have hypothesized that prenatal exposure to DES may also masculinize the gender-role behavior of girls and women. A previous study suggested that prenatally DES-exposed women show decreased interest in parenting. The authors failed to replicate these findings in a different sample despite the use of similar methodology. Post-hoc analysis shows that the assessment devices would have detected masculinization if it were present. The implications of these findings for an understanding of psychosexual development are discussed.
authors.affiliation: New York State Psychiatric Institute, New York 10032.
authors.forename: J D
authors.initials: JD
authors.lastname: Lish
authors.forename: A A
authors.initials: AA
authors.lastname: Ehrhardt
authors.forename: H F
authors.initials: HF
authors.lastname: Meyer-Bahlburg
authors.forename: L R
authors.initials: LR
authors.lastname: Rosen
authors.forename: R S
authors.initials: RS
authors.lastname: Gruen
authors.forename: N P
authors.initials: NP
authors.lastname: Veridiano
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005783:Gender Identity; D006801:Humans; D010556:Personality Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011606:Psychosexual Development / Q000187:drug effects; D012733:Sex Differentiation / Q000187:drug effects*; D012725:Sexual Behavior / Q000187:drug effects
chemical_list: D004054:Diethylstilbestrol