title: Toxic epidermal necrolysis: a burn-centre challenge.
abstract: OBJECTIVE
  To describe the clinical features and outcome of patients with toxic epidermal necrolysis.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Ross Tilley Burn Centre, Wellesley Hospital, Toronto.
  
  
  METHODS
  Ten patients (seven women) with toxic epidermal necrolysis referred to the centre from 1984 to 1990.
  
  
  METHODS
  Biobrane (Winthrop Pharmaceuticals, New York) was applied to all raw surfaces after the epidermis had been completely separated. It was not removed until the epidermis had regenerated.
  
  
  RESULTS
  The age of the patients varied from 27 to 90 (mean 45) years. The proportion of body surface area involved was 20% to 95% (mean 58.5%). Nine of the patients had received steroids and antibiotics prophylactically before being referred to the burn centre; the steroids were immediately tapered and the antibiotics withdrawn unless there was a specific infection. Urinary tract infection developed in seven patients, respiratory failure in six and systemic sepsis in six. All of the patients ultimately required antibiotics for treatment of systemic infections. Two patients died; both had severe illness before the onset of the toxic epidermal necrolysis. Biobrane provided a marked reduction in pain, eliminated the need for further dressings and allowed early, aggressive physiotherapy. The wounds healed completely within 14 to 21 days, with no significant scarring or need for skin grafting.
  
  
  CONCLUSIONS
  The use of a temporary skin substitute is recommended for the treatment of toxic epidermal necrolysis. There is no indication for prophylactic steroid or antibiotic therapy; indeed, such therapy is probably contraindicated.
authors.affiliation: Ross Tilley Burn Centre, Wellesley Hospital, Toronto, Ont.
authors.forename: W
authors.initials: W
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Zaidi
authors.forename: L
authors.initials: L
authors.lastname: Douglas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology; D008875:Middle Aged; D009779:Occlusive Dressings; D011030:Pneumothorax / Q000209:etiology; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000628:therapy*; D014552:Urinary Tract Infections / Q000209:etiology
chemical_list: C042816:Biobrane; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible