Reduction of protein kinase C activity in the adult rat brain following transient forebrain ischemia.
Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia-induced decrease of PKC affected both the soluble and the membrane-bound kinase. Alterations of PKC predate neuronal death following ischemia.
Louis
J C
JC
Centre de Neurochimie du CNRS, Strasbourg, France.
Magal
E
E
Brixi
A
A
Steinberg
R
R
Yavin
E
E
Vincendon
G
G
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002560:Cerebrovascular Circulation; D002546:Ischemic Attack, Transient / Q000201:enzymology*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011493:Protein Kinase C