[Effects of acute nicotine administration on the function of the human parotid gland].
The effect of acute administration of nicotine on the secretory function of the human parotid gland was investigated in 4 male volunteers. After intravenous infusion of 20 micrograms nicotine/kg b.w. within 10 min in all subjects an increased salivary amylase activity and protein concentration was observed. This phenomenon is believed to be caused by a stimulation of parotid beta-adrenoceptors secondary to a nicotine-induced release of catecholamines from the adrenals.
Maier
H
H
Univ.-HNO-Klinik Heidelberg.
Jarczyk
L
L
Scherer
G
G
Born
I A
IA
D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009538:Nicotine / Q000493:pharmacokinetics / Q000494:pharmacology*; D010306:Parotid Gland / Q000187:drug effects*; D012471:Salivary Proteins and Peptides / Q000378:metabolism; D012472:Salivation / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D000516:alpha-Amylases / Q000378:metabolism
D012471:Salivary Proteins and Peptides; D009538:Nicotine; D000516:alpha-Amylases