title: A site-specific deletion in mitochondrial DNA of Podospora is under the control of nuclear genes.
abstract: In the filamentous fungus Podospora anserina, the association of two nuclear genes inevitably leads to a "premature death" phenotype consisting of an early end of vegetative growth a few days after ascospore germination. Mycelia showing this phenotype contain a mitochondrial chromosome that always bears the same deletion. One of the break points is exactly at the 5' splice site of a particular mitochondrial intron, suggesting that the deletion event could result from molecular mechanisms also involved in intron mobility. One of the nuclear genes involved in triggering this site-specific event belongs to the mating-type minus haplotype; the other is a mutant allele of a gene encoding a cytosolic ribosomal protein.
authors.affiliation: Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
authors.forename: L
authors.initials: L
authors.lastname: Belcour
authors.forename: O
authors.initials: O
authors.lastname: Begel
authors.forename: M
authors.initials: M
authors.lastname: Picard
mesh_terms: D001203:Ascomycota / Q000235:genetics*; D001483:Base Sequence; D002470:Cell Survival; D002872:Chromosome Deletion; D004271:DNA, Fungal / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D012269:Ribosomal Proteins / Q000235:genetics
chemical_list: D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D012269:Ribosomal Proteins