Prostaglandin E2 (PGE2) vaginal gel for cervical ripening.
Cervical ripening prior to oxytocin stimulation is highly desirable to ensure a successful induction. Prostaglandin E2 has been administered by intracervical, intravaginal and extra-amniotic routes with successful ripening of the cervix. The dose of PGE2 administered is under investigation. Use of 3 or 4 mg of PGE2, although effective, has been reported to be accompanied by uterine hypertonus or fetal heart changes. Lower dose of PGE2 at 0.2 mg and 0.4 mg do not have the above-mentioned side effects but necessitate multiple applications. This randomized double-blinded study incorporated the use of 2 mg of PGE2 administered by intravaginal route in a hydroxyethyl cellulose gel medium. A significant increase in Bishop score (40% higher) was achieved in patients receiving PGE2 as compared to placebo patients. There were no adverse side effects, indicating application of 2 mg of PGE2 as a safe method of cervical ripening prior to induction of labor.
Chatterjee
M S
MS
Department of Obstetrics and Gynecology, University of New Mexico, School of Medicine, Albuquerque 87131.
Ramchandran
K
K
Ferlita
J
J
Mitrik
L
L
D002584:Cervix Uteri / Q000187:drug effects*; D004106:Dilatation; D015232:Dinoprostone / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005782:Gels / Q000494:pharmacology; D006801:Humans; D007751:Labor, Induced; D010121:Oxytocin / Q000494:pharmacology; D010570:Pessaries; D011247:Pregnancy; D011897:Random Allocation; D012307:Risk Factors
D005782:Gels; D010121:Oxytocin; D015232:Dinoprostone