title: Origin, distribution and morphology of serotonergic afferents to the mesencephalic trigeminal nucleus of the rat.
abstract: We have studied the localization, the morphology and sources of serotonergic input on the primary afferent neurons in the mesencephalic trigeminal nucleus (Me5) of the rat with light and electronmicroscopy immunocytochemistry and with anterograde and retrograde neuroanatomical tract tracing methods. Me5 neurons were found to receive a serotonergic input that is part of a serotonergic fibre plexus extending over the neighbouring parabrachial nucleus and locus coeruleus. These serotonergic afferents originate predominantly from serotonergic cells in the dorsal raphe nucleus.
authors.affiliation: Department of Neurobiology and Oral Physiology, University of Groningen, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Copray
authors.forename: R S
authors.initials: RS
authors.lastname: Liem
authors.forename: G J
authors.initials: GJ
authors.lastname: Ter Horst
authors.forename: J D
authors.initials: JD
authors.lastname: van Willigen
mesh_terms: D000818:Animals; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D008297:Male; D008636:Mesencephalon / Q000648:ultrastructure*; D016253:Microscopy, Immunoelectron; D009475:Neurons, Afferent / Q000648:ultrastructure*; D010835:Phytohemagglutinins; D011903:Raphe Nuclei / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013238:Stereotaxic Techniques; D014278:Trigeminal Nuclei / Q000648:ultrastructure*
chemical_list: D010835:Phytohemagglutinins; D012701:Serotonin; D006735:Horseradish Peroxidase