[A screening survey of variant glycophorins on the erythrocyte membranes among healthy chinese young people].
A screening survey of variant glycophorins (GP) on the erythrocyte membranes was conducted among 114 healthy Chinese young people who belong to several different ethnic groups by immunoblotting techniques. The majority (70) were of the Han ethnic group; 24 out of 41 Hainanese belonged to the Li ethnic group. Ten subjects showed variant GP profiles, with an incidence of 8.8%. The frequency of variants was significantly higher in the Li ethnic group (25%) than in the Han ethnic group (5.7%); none was seen among the other ethnic minorities. Probing with four antibodies specific to different regions of GP molecules revealed three distinct types of GP among the variant individuals. Type I observed in four individuals was reminiscent of that exhibited by Sta glycophorin. Among them, in one subject the Sta blood group phenotype was confirmed by serological typing. The absence of delta GP was noted in another subject carrying type II variant GP. Patterns in the remaining five individuals (type III) could not be correlated with known GP profiles of variants of MNSs blood system. This study suggests that there may be a high incidence of GP variants among certain ethnic groups in China. The sialic acid contents of erythrocyte membranes in seven GP propositi were significantly higher than those of the control.
Wang
L F
LF
Department of Biochemistry, Hunan Medical University, Changsha.
Lu
Y Q
YQ
Fu
M Z
MZ
D000293:Adolescent; D000328:Adult; D044466:Asian People; D002681:China; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005260:Female; D006021:Glycophorins / Q000032:analysis*; D006801:Humans; D008297:Male
D006021:Glycophorins