title: Pilocarpine and digestive efficiency in beef cattle fed a high-concentrate diet.
abstract: The effect of pilocarpine HCl, a parasympathetic muscarinic agonist, on digestive characteristics was evaluated in growing beef steers fed a high-grain diet. Oral doses of 0, 2 or 4 mg/kg BW were administered daily to each of eight steers immediately prior to offering an 88% concentrate: 12% hay diet in this three-period crossover design (19 d/period). Treatments did not improve digestibilities of dry matter, organic matter and nitrogen, ruminal liquid volume and fractional dilution rate, body weight gain or feed efficiency. Although daily voluntary feed intake was not altered by treatment (P = .25), there was a dose-dependent slowing of the rate at which feed was consumed (P less than .01). Also, ruminal fluid pH was increased with increasing dose (5.36, 5.55 and 6.11 respectively; P = .10). These observations indicate that the digestive improvements due to pilocarpine reported to occur in mature, nongrowing cattle consuming a high-forage diet are not observed in growing steers fed a production-type diet.
authors.affiliation: Performance Enhancement Res., Upjohn Company, Kalamazoo, MI 49001.
authors.forename: J P
authors.initials: JP
authors.lastname: Peters
authors.forename: B
authors.initials: B
authors.lastname: Hibbard
authors.forename: R Y
authors.initials: RY
authors.lastname: Shen
authors.forename: S T
authors.initials: ST
authors.lastname: Chester
authors.forename: A M
authors.initials: AM
authors.lastname: Kroger
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004063:Digestion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005232:Fatty Acids, Volatile / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008297:Male; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology*; D012417:Rumen / Q000187:drug effects / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D005232:Fatty Acids, Volatile; D010862:Pilocarpine