Hemin-binding property of Porphyromonas gingivalis outer membranes.
The present study indicates that the outer membranes of Porphyromonas gingivalis have a high affinity for hemin, an essential growth factor for this suspected periodontal pathogen. The hemin-binding property appears to be mediated by the lipopolysaccharides, particularly the lipid A region. It is suggested that this binding mechanism may be important for the growth and establishment of P. gingivalis in environments with a low hemin content such as periodontal pockets.
Grenier
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Département de Santé Buccale, Faculté de Médecine Dentaire, Université de Montréal, Québec, Canada.
D001438:Bacteroidaceae / Q000254:growth & development / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006427:Hemin / Q000378:metabolism*
D006133:Growth Substances; D006427:Hemin