The effect of some chlorhexidine-containing mouthrinses on salivary bacterial counts.
A number of chlorhexidine mouthwashes are available commercially which differ in formulation and regimen of use. As a comparative measure of antimicrobial persistence, this study evaluated the effect of 4 chlorhexidine mouthwash formulations on salivary bacterial counts after a single rinse. The study was a randomised single-examiner blind 5-way crossover investigation employing a panel of 10 young healthy human volunteers. The 0.12% and 0.2% commercial formulations when rinsed according to the respective manufacturers instructions produced similar large and prolonged reductions in salivary bacterial counts during the 7-h period. A 0.1% formulation also commercially available produced minimal effects on salivary bacterial counts and was little different to the saline rinse. A reformulated 0.1% rinse, not commercially available at the time of the study, produced significant salivary bacterial count reductions over the 7-h period albeit to a lesser degree of magnitude than to the 0.2% and 0.12% rinses. The results were consistent with comparative plaque inhibitory studies of the formulations and suggest that the method is a quick and simple way of screening products for antimicrobial and antiplaque potential.
Addy
M
M
Department of Periodontology, University of Wales College of Medicine, Cardiff, UK.
Jenkins
S
S
Newcombe
R
R
D000328:Adult; D000704:Analysis of Variance; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes; D012463:Saliva / Q000382:microbiology*; D016037:Single-Blind Method; D013997:Time Factors
D009067:Mouthwashes; D002710:Chlorhexidine