title: Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs.
abstract: Twenty-six Yeshiva students were randomly assigned to a 24-wk crossover study of monounsaturated fatty acid (MUFA) vs polyunsaturated fatty acid (PUFA) diets (50% carbohydrate, 32% fat, 18% protein) fed alternately during two 12-wk periods. Total plasma cholesterol (TC) decreased significantly by approximately 10% and approximately 16% on the MUFA and PUFA diets, respectively. Plasma triglyceride response was variable. Low-density-lipoprotein cholesterol (LDL-C) decreased in both groups with an additional significant effect between periods. Concentrations of high-density-lipoprotein cholesterol did not change significantly. LDL-receptor status in fresh monocytes, affinity of LDL towards the LDL receptor in cultured fibroblasts, zonal-centrifugation profiles, and lipoprotein composition were not significantly different between the diets. There was a significantly higher tendency toward lipid peroxidation on the PUFA diet, as ascertained by more thiobarbituric acid-reactive-substances formation on that diet. Dietary PUFA results in somewhat lower TC and LDL-C concentrations whereas with MUFA the susceptibility of LDL to oxidative stress is lower.
authors.affiliation: Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: E M
authors.initials: EM
authors.lastname: Berry
authors.forename: S
authors.initials: S
authors.lastname: Eisenberg
authors.forename: D
authors.initials: D
authors.lastname: Haratz
authors.forename: Y
authors.initials: Y
authors.lastname: Friedlander
authors.forename: Y
authors.initials: Y
authors.lastname: Norman
authors.forename: N A
authors.initials: NA
authors.lastname: Kaufmann
authors.forename: Y
authors.initials: Y
authors.lastname: Stein
mesh_terms: D001667:Binding, Competitive; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007557:Israel; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009000:Monocytes / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D011973:Receptors, LDL; D014280:Triglycerides; D002784:Cholesterol