title: Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy.
abstract: Dilated cardiomyopathy in a family of dogs was found to be associated with decreased myocardial L-carnitine concentrations, when compared with those in control dogs. In 2 affected dogs, treatment with high doses of L-carnitine was associated with increased myocardial L-carnitine concentration and greatly improved health and myocardial function. Withdrawal of L-carnitine supplementation from these dogs resulted in development of myocardial dysfunction and clinical signs of dilated cardiomyopathy.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
authors.forename: B W
authors.initials: BW
authors.lastname: Keene
authors.forename: D P
authors.initials: DP
authors.lastname: Panciera
authors.forename: C E
authors.initials: CE
authors.lastname: Atkins
authors.forename: V
authors.initials: V
authors.lastname: Regitz
authors.forename: M J
authors.initials: MJ
authors.lastname: Schmidt
authors.forename: A L
authors.initials: AL
authors.lastname: Shug
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D002331:Carnitine / Q000172:deficiency* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D008297:Male
chemical_list: D002331:Carnitine