title: Multidrug transport in human glioblastoma cells is inhibited by transforming growth factors type beta 1, beta 2, and beta 1.2.
abstract: The transforming growth factors type beta 1, beta 2, and beta 1.2 suppress multidrug transport in human pat-1 glioblastoma cells and even in cells that strongly over-express mdr genes and are resistant to inhibition of multidrug transport by chemosensitizers. Thus, inhibition of multidrug transport by cytokines might be a new approach to increase cellular accumulation of chemotherapeutic agents in multidrug resistant glial tumor cells. Interestingly, a member of the more distantly related decapentaplegic subgroup of transforming growth factors, the bone morphogenetic protein BMP 2, did not inhibit multidrug transport.
authors.affiliation: Department of Neurology, University of Wuerzburg, Federal Republic of Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Schluesener
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D004336:Drug Antagonism; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020112:Rhodamine 123; D012235:Rhodamines; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; D016212:Transforming Growth Factor beta; D020112:Rhodamine 123