Human lymphocyte responsiveness is not enhanced by relief of biliary obstruction: an in-vitro study.
Imparied cell-mediated immunity has been described in obstructive jaundice and has been attributed to depressant serum factors or to depressed intrinsic T-cell function. The authors studied lymphocyte responsiveness to phytohemagglutinin stimulation, the in-vitro correlate of T-cell function, in 11 patients with biliary obstruction. Peripheral-blood mononuclear cells and serum were obtained before (mean serum bilirubin level 302 mumol/L) and after (mean serum bilirubin level 23 mumol/L) treatment of the biliary obstruction. Simultaneous cell culture of all samples disclosed no evidence of a serum depressant factor in patients with obstructive jaundice, and crossover incubation studies failed to suggest that there is a depression of intrinsic T-cell responsiveness that can be reversed by biliary drainage.
Pace
R F
RF
Hepato-Biliary Surgery Unit, Hammersmith Hospital, Royal Post-Graduate Medical School, London, UK.
Gonzaga
R
R
Kaminski
E
E
Hodgson
H J
HJ
Benjamin
I S
IS
D000368:Aged; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D008875:Middle Aged; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins; D001663:Bilirubin