[Effects of nifedipine, in primary hypertension, on calcium metabolism and on the excretion of the main urinary electrolytes].
The short term or acute intravenous administration of nifedipine has been reported to increase urine flow rate and sodium clearance but does not significantly alter the patient's serum or urine electrolytes as other vasodilators. Still comparatively little is known, however, about the effects of antihypertensive drugs on calcium metabolism. Our data, on 15 hypertensive patients with normal renal function, don't show significative changes in plasma or urine levels of calcium in short term treatment; moreover there isn't water and salt retention. Thus nifedipine is confirmed as a prime choice drug in hypertensive patients with normal renal function.
Rivetti
V
V
Divisione di Nefrologia e Dialisi, Ospedale di Cremona.
Ariano
R
R
Gnocchi
E
E
Pecchini
F
F
D002118:Calcium / Q000378:metabolism*; D004573:Electrolytes / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D004573:Electrolytes; D009543:Nifedipine; D002118:Calcium