title: Improvement in survival of patients with congenital diaphragmatic hernia utilizing a strategy of delayed repair after medical and/or extracorporeal membrane oxygenation stabilization.
abstract: Patients with congenital diaphragmatic hernia (CDH) symptomatic at birth treated at this institution over the past 6 years were reviewed. The patients were divided into two chronological groups for analysis: group 1, consisting of 15 patients treated from January 1984 through October 1987, a period during which acute CDH was considered to be a surgical emergency; and group 2, comprising 20 patients treated from November 1987 through October 1989 using a management protocol of delayed repair following medical and/or extracorporeal membrane oxygenation (ECMO) stabilization. These two groups did not differ significantly in gestational age, birth weight, Apgar scores, hernia side, or age at admission. Group 2 had a longer mean interval from admission to repair (26.5 v 1.8 h, P = .01) and average age at repair (31.0 v 6.5 h, P = .02) than did group 1. Prosthetic closure of the diaphragmatic defect was required more frequently in group 2 then in group 1 (63% v 31%, P = .07). Survival in group 2 was significantly greater than in group 1 (55% v 20%, P = .04). Seven group 2 patients (35%) achieved a prerepair or pre-ECMO PO2 greater than 100 mm Hg and all survived; four of the 13 "nonresponders" also survived. ECMO was used in 11 group 2 patients with five survivors (45%); four of these patients underwent repair prior to ECMO and seven underwent repair while on ECMO.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, Children's Hospital of Alabama, Birmingham 35233.
authors.forename: C W
authors.initials: CW
authors.lastname: Breaux
authors.forename: T M
authors.initials: TM
authors.lastname: Rouse
authors.forename: W S
authors.initials: WS
authors.lastname: Cain
authors.forename: K E
authors.initials: KE
authors.lastname: Georgeson
mesh_terms: D015199:Extracorporeal Membrane Oxygenation; D006548:Hernia, Diaphragmatic / Q000401:mortality* / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D011379:Prognosis; D016019:Survival Analysis