Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee).
A double-blind, crossover, 8-wk study was conducted to compare effects of the tocotrienol-enriched fraction of palm oil (200 mg palmvitee capsules/day) with those of 300 mg corn oil/d on serum lipids of hypercholesterolemic human subjects (serum cholesterol 6.21-8.02 mmol/L). Concentrations of serum total cholesterol (-15%), LDL cholesterol (-8%), Apo B (-10%), thromboxane (-25%), platelet factor 4 (-16%), and glucose (-12%) decreased significantly only in the 15 subjects given palmvitee during the initial 4 wk. The crossover confirmed these actions of palmvitee. There was a carry over effect of palmvitee. Serum cholesterol concentrations of seven hypercholesterolemic subjects (greater than 7.84 mmol/L) decreased 31% during a 4-wk period in which they were given 200 mg gamma-tocotrienol/d. This indicates that gamma-tocotrienol may be the most potent cholesterol inhibitor in palmvitee capsules. The results of this pilot study are very encouraging.
Qureshi
A A
AA
Advanced Medical Research, Madison, WI 53719.
Qureshi
N
N
Wright
J J
JJ
Shen
Z
Z
Kramer
G
G
Gapor
A
A
Chong
Y H
YH
DeWitt
G
G
Ong
A
A
Peterson
D M
DM
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001053:Apolipoproteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002839:Chromans; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D013929:Thromboxane B2 / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
D000975:Antioxidants; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002839:Chromans; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014810:Vitamin E; D010978:Platelet Factor 4; C013649:plastochromanol 8; D013929:Thromboxane B2; D002784:Cholesterol