Sister chromatid exchange in children of Seventh-Day Adventists and matched controls.
The low risk of cancer in Seventh-Day Adventists (SDAs) has been suggested to be due to genetic selection. To investigate this claim we examined the sister chromatid exchange (SCE) frequency in peripheral blood lymphocytes in 16 SDA children in Tromsø, all aged 0.5-8 years and 16 controls matched for sex and age. In 12 of 16 pairs, the SDA children had a lower SCE frequency than the controls. The mean difference was 4.06 (95% confidence interval -17.02-8.89, P = 0.51). There was no sex difference, and no correlation between age and SCE frequency. The genetic starting point with regard to SCE frequency seems to be the same for SDA children and controls.
Hermansen
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R
Halden Hospital, Oslo, Norway.
Waksvik
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H
Fønnebø
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V
D002648:Child; D002675:Child, Preschool; D002835:Christianity; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008019:Life Style; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D012854:Sister Chromatid Exchange / Q000235:genetics*