Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments.
Acute hepatitis is a potential, although rare, complication following administration of high doses of Etoposide (VP 16-213). We report three cases of severe hepatocellular necrosis following administration of standard doses of this antineoplastic agent.
Tran
A
A
Unité d'Hépatologie, Hôpital Laënnec, Paris, France.
Housset
C
C
Boboc
B
B
Tourani
J M
JM
Carnot
F
F
Berthelot
P
P
D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D005047:Etoposide