title: Comparison of reflex modification procedures and auditory brainstem response in high-risk neonates.
abstract: This study compared the results of reflex modification (RM)--an objective technique for assessing brainstem sensorineural processing--with those of auditory brainstem response (ABR) for a group of high-risk infants at comparable postconceptional ages. For the RM procedure, an eyeblink-eliciting tap to the glabella was presented either alone or accompanied by a brief 90dB SPL tone. 37 high-risk infants were tested with both RM and ABR at a mean postconceptional age of 37.3 weeks. Seven had an increased brainstem conduction time ('failed ABR') and eight did not exhibit significant reflex augmentation ('failed RM'), seven of whom also failed the ABR. These data provide evidence that sensory stimuli which affect the neural mechanisms responsible for the organization of the startle response and auditory processing share essential neural components.
authors.affiliation: Department of Pediatrics, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors.forename: E K
authors.initials: EK
authors.lastname: Anday
authors.forename: M E
authors.initials: ME
authors.lastname: Cohen
authors.forename: H S
authors.initials: HS
authors.lastname: Hoffman
mesh_terms: D001306:Auditory Pathways / Q000503:physiopathology; D001767:Blinking / Q000502:physiology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000503:physiopathology; D009460:Neurologic Examination / Q000295:instrumentation*; D012021:Reflex, Abnormal / Q000502:physiology*; D012307:Risk Factors