Tourette syndrome attributed to frontal lobe dysfunction: numerous etiologies involved.
The etiology of Tourette Syndrome (TS) according to prevailing views is unknown; there is evidence for both familial and sporadic cases. The author theorizes that abnormal discharges in the frontal lobes comprise the "final common dysfunction" that results in numerous phenomena labelled Tourette syndrome. Facial, vocal, and other motor symptoms of TS are catalogued in parallel with facial, vocal, and body movements that occur during frontal lobe seizures. The variety of etiologies that cause frontal lobe seizures--when applied to TS--can account more readily for heterogeneity of clinical presentations, the numerous "dual diagnosis" cases, and differential response to medication than can a single-gene theory.
Gedye
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Provincial Facility for Mentally Handicapped Adults, New Westminster, British Columbia, Canada.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D004569:Electroencephalography; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D012640:Seizures / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D009626:Terminology as Topic; D005879:Tourette Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology