title: Growth of the cartilages of the mid-line cranial base of the Wistar rat: an autoradiographic study using 35S-sulphate.
abstract: Matrix synthesis in the mid-line cranial base of the rat was studied using a single injection of 35S-sulphate in animals aged 4-80 days. High uptake of 35S-sulphate in the morphologically distinct zone of early hypertrophy led to it being renamed the Matrixogenic Zone. Relocation of 35S-sulphate label into the primary spongiosa was used to estimate the growth rate of each site of endochondral ossification. This showed a marked caudorostral and temporal gradient. In addition, there was a caudorostral and temporal gradient in hypertrophic cell size, but only a temporal gradient in the rate of cell loss.
authors.affiliation: Department of Paediatric Dentistry, U.M.D.S., London.
authors.forename: G J
authors.initials: GJ
authors.lastname: Roberts
authors.forename: H J
authors.initials: HJ
authors.lastname: Blackwood
mesh_terms: D000818:Animals; D001345:Autoradiography; D001857:Bone Matrix / Q000166:cytology; D002356:Cartilage / Q000166:cytology / Q000254:growth & development*; D002470:Cell Survival; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012886:Skull / Q000166:cytology / Q000254:growth & development*; D013431:Sulfates; D013462:Sulfur Radioisotopes; D013997:Time Factors
chemical_list: D013431:Sulfates; D013462:Sulfur Radioisotopes