title: Protracted infusion of 5-FU with weekly low-dose cisplatin as second-line therapy in patients with metastatic colorectal cancer who have failed 5-FU monotherapy.
abstract: Forty four patients who had documented progression of metastatic colorectal cancer while receiving 5-fluorouracil (5-FU) monotherapy were treated with continuous infusion 5-FU, 300 mg/mg2/day, plus weekly low-dose cisplatin, 20 mg/m2. Treatment was given in 12-week cycles, consisting of 8 weeks of chemotherapy followed by a 4-week rest period, and was well tolerated. Three of 23 patients (13%) who had failed bolus 5-FU but not been exposed previously to infusional 5-FU responded. Of 21 patients who had failed infusional 55-FU monotherapy, only one (5%) responded. Time to progression (5.7 vs. 1.8 months) and survival (12 vs. 5.5 months) were significantly longer for patients who had not previously received infusional 5-FU but who had failed bolus schedules, compared with patients who had previously failed infusional 5-FU (p less than .001).
authors.affiliation: Division of Hematology-Oncology, George Washington University Medical Center, Washington, DC.
authors.forename: J D
authors.initials: JD
authors.lastname: Ahlgren
authors.forename: O
authors.initials: O
authors.lastname: Trocki
authors.forename: J J
authors.initials: JJ
authors.lastname: Gullo
authors.forename: R
authors.initials: R
authors.lastname: Goldberg
authors.forename: W A
authors.initials: WA
authors.lastname: Muir
authors.forename: R
authors.initials: R
authors.lastname: Sisk
authors.forename: L
authors.initials: L
authors.lastname: Schacter
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis
chemical_list: D002945:Cisplatin; D005472:Fluorouracil