Protection against cis-diamminedichloroplatinum-induced nephrotoxicity in rats by N-benzyl-D-glucamine dithiocarbamate.
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD) was evaluated for its efficacy as an inhibitor of cis-diamminedichloroplatinum (DDP)-induced nephrotoxicity in a rat model. Treatment with 2.0 mmol/kg of BGD immediately after DDP injection effectively prevented nephrotoxic effects of DDP, but administration of BGD -1 or 1 h after DDP afforded a small protection. Concurrent treatment with 0.5 mmol/kg of BGD could not prevent renal damage. The platinum concentrations in liver and kidney were significantly decreased by BGD treatment. The antitumor efficacy of DDP in the Walker 256 carcinoma-bearing rats was not affected by administration of BGD (2.0 mmol/kg).
Kiyozumi
M
M
Department of School Health, Faculty of Education, Kumamoto University, Japan.
Inoue
T
T
Kojima
S
S
Hidaka
S
S
Tsuruoka
M
M
D000818:Animals; D001219:Aspartate Aminotransferases / Q000652:urine; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D006029:Glycosuria / Q000139:chemically induced; D007668:Kidney / Q000737:chemistry / Q000187:drug effects*; D008099:Liver / Q000737:chemistry; D008297:Male; D010984:Platinum / Q000032:analysis; D011507:Proteinuria / Q000139:chemically induced; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D010984:Platinum; D013012:Sorbitol; D001219:Aspartate Aminotransferases; C048763:N-benzylglucamine dithiocarbamate; D002945:Cisplatin