title: [A case of bilateral sudden hearing loss and vertigo caused by bilateral temporal bone metastasis from pancreatic carcinoma--comparison of clinical findings and temporal bone pathological findings].
abstract: We report temporal bone pathology in a 25-year-old man with bilateral temporal bone adenocarcinoma which was caused by metastasis from a primary lesion in the pancreas. The initial symptoms began with vertigo and headache and the patient noticed left hearing loss in the left ear on the following day. A few days later, he noticed hearing loss in the right ear, and bilateral hearing was totally lost within two weeks of the onset. In addition to severe bilateral sensorineural hearing loss, left IInd, bilateral Vth and VIIIth cranial nerve paralysis occurred. Brain CT showed multiple metastatic lesions in the brain. The patient's general condition rapidly deteriorated, and he died of acute pneumonia on the 42nd day after onset. At autopsy it was revealed adenocarcinoma of the tail and body of the pancreas and its metastasis to the brain and meninges. Pathological study of the temporal bone showed infiltration of carcinomatous cells along the VIIth and VIIIth nerves in the bilateral internal auditory canals.
authors.affiliation: Department of Otolaryngology, Teikyo University School of Medicine, Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohira
authors.forename: K
authors.initials: K
authors.lastname: Kaga
authors.forename: A
authors.initials: A
authors.lastname: Kodama
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D000328:Adult; D006312:Hearing Loss, Bilateral / Q000209:etiology*; D003639:Hearing Loss, Sudden / Q000209:etiology*; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology*; D012888:Skull Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D013701:Temporal Bone / Q000473:pathology*; D014717:Vertigo / Q000209:etiology*