title: The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study.
abstract: Oat cereals rich in the water-soluble fiber beta-glucan have been studied as a dietary therapy for hypercholesterolemia. To determine the hypocholesterolemic response of beta-glucan in the diet, 156 adults with low-density lipoprotein cholesterol (LDL-C) levels above 4.14 mmol/L (160 mg/dL) or between 3.37 and 4.14 mmol/L (130 and 160 mg/dL) with multiple risk factors were randomized to one of seven groups. Six groups received either oatmeal or oat bran at doses (dry weight) of 28 g (1 oz), 56 g (2 oz), and 84 g (3 oz). A seventh group received 28 g of farina (beta-glucan control). At week 6 of treatment, significant differences were found for both total cholesterol and LDL-C levels among the farina control and the treatment groups who were receiving 84 g of oatmeal, 56 g of oat bran, and 84 g of oat bran, with decreases in LDL-C levels of 10.1%, 15.9%, and 11.5%, respectively. Fifty-six grams of oat bran resulted in significantly greater reductions in LDL-C levels than 56 g of oatmeal. Nutrient analysis shows no difference in dietary fat content between these treatment groups; therefore, the higher beta-glucan content of oat bran most likely explains the significantly greater LDL-C reductions. A dose-dependent reduction in LDL-C levels with oat cereals supports the independent hypocholesterolemic effects of beta-glucan.
authors.affiliation: Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago Center for Clinical Research, IL 60607.
authors.forename: M H
authors.initials: MH
authors.lastname: Davidson
authors.forename: L D
authors.initials: LD
authors.lastname: Dugan
authors.forename: J H
authors.initials: JH
authors.lastname: Burns
authors.forename: J
authors.initials: J
authors.lastname: Bova
authors.forename: K
authors.initials: K
authors.lastname: Story
authors.forename: K B
authors.initials: KB
authors.lastname: Drennan
mesh_terms: D000328:Adult; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D002523:Edible Grain; D005260:Female; D005936:Glucans / Q000008:administration & dosage*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012189:Retrospective Studies; D016037:Single-Blind Method
chemical_list: D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005936:Glucans