title: Peripheral ulcerative keratitis associated with hideradenitis suppurativa.
abstract: Peripheral ulcerative keratitis (PUK) is a noninfectious inflammation and ulceration of the peripheral cornea. It may be idiopathic--i.e., Mooren's ulcer--or it may be associated with a variety of systemic disorders, including many collagen vascular diseases. We present a patient who had bilateral peripheral infiltrative and ulcerative keratitis in association with severe hideradenitis suppurativa (HS), a suppurative and cicatricial disease of the apocrine glands of the skin. The peripheral ulcerative keratitis was unresponsive to all routine treatment modalities, but it finally responded to immunosuppression by cyclophosphamide, given orally. To the best of our knowledge, there is only one report in the dermatology literature citing the association of hideradenitis suppurativa and interstitial keratitis.
authors.affiliation: Ophthalmology Service, D.C. General Hospital, Washington, D.C. 20003.
authors.forename: M A
authors.initials: MA
authors.lastname: Mahmood
authors.forename: S
authors.initials: S
authors.lastname: Pillai
authors.forename: S R
authors.initials: SR
authors.lastname: Limaye
mesh_terms: D000328:Adult; D001050:Apocrine Glands; D003320:Corneal Ulcer / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013543:Sweat Gland Diseases / Q000150:complications*; D014792:Visual Acuity
chemical_list: D003520:Cyclophosphamide