title: [Results of transabdominal placental biopsy in the 2nd and 3d trimester].
abstract: From August 1988 to October 1990, 115 transabdominal placental biopsies were performed in the second (68%) and third trimenon (32%). The main indication (80%) was the detection of pathological ultrasonographic findings (foetal malformation, growth retardation, oligohydramnios and polyhydramnios). The success rate of chorionic villus sampling (89%) was independent of the localisation of the placenta. A definite cytogenetic result was found in 83% of patients. By combination of placental biopsy and amniocentesis (n = 77) karyotyping was successful in 97% of pregnancies. Chromosomal abnormalities were observed in 15 (13%) cases (7 autosomal and 2 gonosomal aneuploidies, 1 unbalanced translocation, 1 autosomal deletion, 4 structural variants). The outcome of the pregnancies was substantially influenced by the indication for the procedure and by the cytogenetic result. Foetal and peri-/neonatal losses were found in 53% (3% spontaneous abortions) of patients with sonographic abnormalities (n = 92) and in 9% (abortion rate 4%) of pregnancies with regular findings (n = 23). The pregnancy loss rates were 37.7% and 5.9%, respectively. The results confirm the clinical significance of placental biopsy in the management of pregnancies with pathological ultrasonographic findings.
authors.affiliation: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universität zu Köln.
authors.forename: G
authors.initials: G
authors.lastname: Crombach
authors.forename: S
authors.initials: S
authors.lastname: Schütz
authors.forename: K H
authors.initials: KH
authors.lastname: Schlensker
mesh_terms: D002824:Chorionic Villi / Q000473:pathology; D015193:Chorionic Villi Sampling / Q000379:methods*; D000013:Congenital Abnormalities / Q000235:genetics / Q000473:pathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D016104:Oligohydramnios / Q000473:pathology*; D006831:Polyhydramnios / Q000473:pathology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D016216:Ultrasonography, Prenatal / Q000379:methods*
vernacular_title: Ergebnisse der transabdominalen Plazentabiopsie im II. und III. Trimenon.