[The role of different sections of the striatum in rats in organizing minute fluctuations of stereotyped behavior and tolerance to the use of fenamine].
Bilateral lesions of the dorsal striatum in rats attenuated amphetamine-induced stereotyped behaviour and limited its minute fluctuations with a decrease in intensity of short-period (minutes) waves. After lesion of the ventral region their intensity, on the contrary, rose. A higher sensitivity to chronic administration of amphetamine (2 weeks, 5 mg/kg daily) with an increase in intensity of rhythmic fluctuations of stereotyped behaviour was observed in animals with dorsal striatectomy. Directly opposite results were obtained in the second group of rats. It is suggested that the dorsal striatum is connected with the generation of high-frequency fluctuations in the time course of stereotyped behaviour and brings about a faster adaptation to amphetamine.
Arushanian
E B
EB
Popov
A V
AV
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D004361:Drug Tolerance; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000661:Amphetamine
Rol' razlichnykh otdelov striatuma krys v organizatsii minutnykh kolebaniĭ stereotipnogo povedeniia i tolerantnosti pri ispol'zovanii fenamina.