Influence of chlorpromazine on the toxicity of pirarubicin in mice.
The influence of chlorpromazine (CPZ) on the toxicity of pirarubicin (THP) was examined in mice. CPZ significantly enhanced the acute toxicity and bone marrow toxicity induced by THP. These results demonstrate that that in vivo combination of THP and CPZ at high doses will result in an increase of toxicity in mice.
Maekawa
I
I
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Shibata
H
H
Furusawa
S
S
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000633:toxicity; D008297:Male; D051379:Mice
D004317:Doxorubicin; C027260:pirarubicin; D002746:Chlorpromazine