[Persistence of the measles virus genome in peripheral blood lymphocytes in patients with glomerulonephritis and systemic lupus erythematosus].
Punctate hybridization was used to examine measles virus genome in peripheral blood lymphocytes from patients with glomerulonephritis (GN) and systemic lupus erythematosus (SLE). Measles virus genome was revealed in 47 (54%) out of 87 GN patients, in 27 (74%) out of 36 SLE patients and in none of the control group patients. GN patients manifested a tendency towards increase of the rate of measles virus demonstration with the rise of the titres of measles antibodies. All SLE patients with a high antibody titre (1:512 and higher) demonstrated measles virus genome. The rate of measles virus genome demonstration in GN and SLE patients did not depend on the sex, age, duration and clinical disease pattern or the content of IgA, IgM, IgG in blood serum. During disease exacerbation, the rate of measles virus demonstration was higher in 41 (59.4%) out of 69 patients than during remission--in 6 (33.3%) out of 18 patients (p less than 0.05).
Nevraeva
E G
EG
Bogomolova
N N
NN
Chaplygina
N M
NM
Zavalishin
I A
IA
Filimonova
R G
RG
D000293:Adolescent; D000328:Adult; D005260:Female; D005814:Genes, Viral; D005921:Glomerulonephritis / Q000382:microbiology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology*; D008297:Male; D008459:Measles virus / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D009693:Nucleic Acid Hybridization
Persistentsiia genoma virusa kori v limfotsitakh perifericheskoĭ krovi u bol'nykh glomerulonefritom i sistemnoĭ krasnoĭ volchankoĭ.