title: [Evaluation of cardiac function during KCl-induced paralytic attack in the patients with normokalemic periodic paralysis].
abstract: Some reports have been written about hypokalemic periodic paralysis dealing with cardiac dysfunction and arrhythmia during the paralytic attack. However, no reports have been written about the cardiac function during the attack in cases of normokalemic periodic paralysis. So, we investigated cardiac function in two patients with normokalemic periodic paralysis. A 3.0 g dose of KCl was administered orally to the patients (1 male, 1 female) and 10 healthy volunteers (5 males, 5 females). Cardiac function by using ejection time (ET)/pre-ejection period (PEP), grasping power, and the level of plasma catecholamine were measured during the paralytic attack. Changes in the patients were compared with those in the volunteers. Next, a 3.0 g dose of KCl was administered to the patient, followed by intravenous dosing of 10% NaCl (50 ml) after which ET/PEP and grasping power measured. Lastly, a 60 mg dose of diltiazem, a 10 mg dose of nifedipine or a 80 mg dose of verapamil were administered, followed by a 3.0 g dose of KCl after which ET/PEP and grasping power were measured again. Thirty minutes after the administration of KCl, the grasping power decreased remarkably, from 32.0 kg to 17.0 kg in the male patient and from 30.0 kg to 20.0 kg in the female patient. By contrast, the ET/PEP showed a clear increase, from 3.47 to 6.17 in the male patient and from 2.84 to 5.45 in the female patient. Grasping power of the volunteers, however, did not change remarkably (avg. 40.3 kg before vs. 40.9 kg after in the males and avg. 26.9 kg before vs. 26.0 kg after in the females) and ET/PEP of the volunteers did not change remarkably (avg. 3.37 before vs. 3.17 after in the males and avg. 3.30 before vs. 3.43 after in the females). No significant changes were found in the levels of plasma catecholamine during the paralytic attack.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: First Department of Internal Medicine, School of Medicine, University of Tokushima.
authors.forename: T
authors.initials: T
authors.lastname: Sebe
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Mizobuchi
authors.forename: S
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D010243:Paralysis / Q000097:blood / Q000503:physiopathology*; D010507:Periodicity; D011188:Potassium / Q000097:blood*; D011189:Potassium Chloride; D011782:Quadriplegia / Q000097:blood / Q000503:physiopathology
chemical_list: D011189:Potassium Chloride; D011188:Potassium