title: The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology.
abstract: Lactate dehydrogenase (LDH) isoenzyme distribution was examined in 106 urine samples being tested cytologically for evidence of bladder cancer; the samples were selected to have less than 20 leucocytes and erythrocytes per high power field and the LDH pattern determined by electrophoresis. The Papanicolaou stained-smears showed 68 negative, 17 suspicious and 21 positive. The LDH M-fraction of the urinary supernatant in cytologically positive cases was significantly greater than in negative cases, although the latter included a few false negative samples. Some of the false negatives gave positive results for the LDH M-fraction; these results suggest that the determination of LDH isoenzymes in the urine is useful in diagnosing urinary tract cancers, including early stage, and for follow-up of patients with bladder cancers after surgical resection.
authors.affiliation: Department of Pathology, Gifu University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Fujihiro
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000652:urine; D004796:Clinical Enzyme Tests; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000652:urine*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase