[Anti-idiotype antibodies].
The discovery of idiotypes by Oudin and Kunkel, followed by the idiotype network theory by Jerne have opened a new field of investigation of the humoral immune response and of its regulation. The presence of anti-idiotypes behaving like "internal images" and the ability of anti-idiotypes to modulate the immune response in animals lead the way to new therapeutic regimens in very various fields such as auto-immune diseases or vaccinations. However, many theoretical as well as practical problems need to be solved before the actual use of such reagents in clinical medicine.
Glotz
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Service de néphrologie et unité INSERM U 28, hôpital Broussais, Paris.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D000917:Antibody Formation / Q000502:physiology; D006801:Humans
D000888:Antibodies, Anti-Idiotypic
Anticorps anti-idiotypes.