title: Azathioprine induced liver disease: nodular regenerative hyperplasia of the liver and perivenous fibrosis in a patient treated for multiple sclerosis.
abstract: Azathioprine hepatotoxicity has been described mainly in renal transplant recipients. Most reported cases are related to lesions of the venous system of the liver: peliosis hepatis, veno-occlusive disease of the liver, perisinusoidal fibrosis, and nodular regenerative hyperplasia of the liver. The most common clinical manifestation of these hepatic vascular lesions is portal hypertension. We present a case of nodular regenerative hyperplasia and perivenous fibrosis in a patient receiving azathioprine for multiple sclerosis. Histological abnormalities were similar to those described in renal transplant patients, and azathioprine was the only potential hepatotoxic agent present.
authors.affiliation: Department of Gastroenterology, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
authors.forename: F
authors.initials: F
authors.lastname: Mion
authors.forename: B
authors.initials: B
authors.lastname: Napoleon
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Chevallier
authors.forename: S
authors.initials: S
authors.lastname: Bonvoisin
authors.forename: L
authors.initials: L
authors.lastname: Descos
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D001379:Azathioprine