title: Age-related morphologic changes in the human tympanic membrane. A light and electron microscopic study.
abstract: To our knowledge, the normal changes that occur in the tympanic membrane after birth have not been described, despite several reports that their otoscopic appearance in healthy, full-term infants is different from that in adults. To provide such a description, the tympanic membranes of 54 temporal bones that had no pathologic evidence of otologic diseases, from patients aged 33 weeks' gestation to 91 years, were examined with light or electron microscopy. The changes encountered in thickness, cellularity, vascularity, collagen, and elastin indicated beyond the first year of life and into old age.
authors.affiliation: University of Minnesota Otitis Media Research Center, Department of Otolaryngology, Minneapolis.
authors.forename: C B
authors.initials: CB
authors.lastname: Ruah
authors.forename: P A
authors.initials: PA
authors.lastname: Schachern
authors.forename: D
authors.initials: D
authors.lastname: Zelterman
authors.forename: M M
authors.initials: MM
authors.lastname: Paparella
authors.forename: T H
authors.initials: TH
authors.lastname: Yoon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003094:Collagen; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004848:Epithelium / Q000033:anatomy & histology / Q000648:ultrastructure; D005347:Fibroblasts / Q000166:cytology / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008648:Mesoderm / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009092:Mucous Membrane / Q000033:anatomy & histology / Q000648:ultrastructure; D014432:Tympanic Membrane / Q000033:anatomy & histology* / Q000098:blood supply / Q000648:ultrastructure
chemical_list: D003094:Collagen