[Bone marrow transplantation in the treatment of severe aplastic anemia].
Bone marrow transplantation (BMT) in patient affected by severe aplastic anemia (SAA), is successful in 70-80% of cases, when performed with HLA identical brother or syngeneic twin as donors, and in 11-45% of cases when performed from aploidentical-identical related or HLA identical unrelated donor. The different conditioning regimens (Cy alone or in combination with TBI) have shown similar results in the long term outcomes. Cyclosporin-A is very effective in avoiding rejection and controlling GVHD.
Locatelli
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Clinica Pediatrica, Università di Pavia, IRCCS Policlinico S. Matteo, Italia.
Zecca
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M
Nespoli
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L
Severi
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F
D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male
Il trapianto di midollo osseo nel trattamento dell'anemia aplastica grave.