title: The effects of a hyperosmolar intravenous contrast medium on blood viscosity.
abstract: The effects of the hyperosmolar contrast medium, diatrizoate meglumine (Renografin-76) on blood viscosity and other metabolic parameters were measured in 20 immature piglets. Intravenous contrast medium caused a significant (P less than .5) increase in serum osmolality, cardiac output, and urine output, and a decrease in hematocrit. There was a fall in blood viscosity that was not statistically significant. These changes, which are attributed to an acute shift of fluid into the hyperosmolar vascular compartment, were greatest at 3 minutes following injection and subsequently returned towards baseline levels. We conclude that blood viscosity is not increased following intravenous injection of hyperosmolar radiocontrast media.
authors.affiliation: Department of Pediatric Surgery, Children's Hospital of Pittsburgh, Pennsylvania.
authors.forename: D A
authors.initials: DA
authors.lastname: Lloyd
authors.forename: J S
authors.initials: JS
authors.lastname: Stein
authors.forename: M I
authors.initials: MI
authors.lastname: Rowe
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004338:Drug Combinations; D009994:Osmolar Concentration; D013552:Swine
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision