title: Raynaud's phenomenon with digital necrosis as the first manifestation of undifferentiated connective tissue syndrome.
abstract: A patient with severe Raynaud's phenomenon (RP) associated with the presence of antibodies against extractable nuclear antigen (ribonucleoprotein) in the context of undifferentiated connective tissue syndrome is presented. The rapid course of digital necrosis in her case resulted in the surgical amputation of 9 of her fingers. We conclude that massive digital necrosis accompanied by severe RP could constitute the first manifestation of a connective tissue disease.
authors.affiliation: Department of Internal Medicine, Ramón y Cajal Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sabán
authors.forename: J L
authors.initials: JL
authors.lastname: Rodríguez-García
authors.forename: J R
authors.initials: JR
authors.lastname: País
authors.forename: N
authors.initials: N
authors.lastname: Mellado
authors.forename: E
authors.initials: E
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D003240:Connective Tissue Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005385:Fingers / Q000473:pathology / Q000601:surgery; D006801:Humans; D009336:Necrosis; D011928:Raynaud Disease / Q000150:complications / Q000473:pathology* / Q000601:surgery