[Chemotherapeutic effectiveness of doxycycline in experimental Q fever].
Comparative chemotherapeutic efficacy of doxycycline administered orally or parenterally was studied on a model of experimental Q fever in guinea pigs and albino mice. The advantage of the parenteral use of the antibiotic was observed only in the treatment of the albino mice. Optimization of the doses and time of doxycycline use providing the maximum therapeutic effect and the required levels of the complement binding antibodies was achieved with employing the multifactorial analysis.
Nikitin
A V
AV
Klimchuk
N D
ND
Fomina
I P
IP
Rozdobul'ko
V N
VN
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D011778:Q Fever / Q000188:drug therapy*
D004318:Doxycycline
Khimioterapevticheskaia éffektivnost' doksitsiklina pri éksperimental'noĭ Ku-rikketsioznoĭ infektsii.