title: [Hypnotic doses of midazolam administered by continuous perfusion. Analysis of predictive factors].
abstract: The hypnotic dose of midazolam administered in continuous perfusion was investigated in 76 patients undergoing programmed traumatologic or orthopedic surgery. In all cases an infusion of midazolam at a rate of mg-1 kg-1 h-1 was administered until patients closed eyes but opened them under auditive stimuli (hypnotic dose of midazolam). This dose was 5.25 +/- 2.78 mg (0.08 +/- 0.04 mg/kg) and showed a statistically significant correlation with age (r = 0.43, p = 0.002) and weight (r = 0.3, p = 0.02). There was no significant correlation with sex, ASA class, premedication, plasma proteins, and plasma albumin. Interindividual variability, especially in young patients, was high.
authors.affiliation: Departamento de Anestesiología y Reanimación, Hospital Clínic i Provincial, Barcelona.
authors.forename: J
authors.initials: J
authors.lastname: Castillo
authors.forename: A
authors.initials: A
authors.lastname: Bogdanovich
authors.forename: E
authors.initials: E
authors.lastname: Carrero
authors.forename: C
authors.initials: C
authors.lastname: Lapena
authors.forename: M A
authors.initials: MA
authors.lastname: Nalda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006991:Hypnosis, Anesthetic; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged
chemical_list: D008874:Midazolam
vernacular_title: Dosis hipnótica de midazolam administrado en perfusión continua. Análisis de los factores predictivos.