[Hepatic activity of glutathione transferase and bromsulphalein metabolism].
The gluthatione transferase activity has been studied in liver biopsies from patients suffering with different hepatic lesion and related to the bromsulphalein (BSP) maximal transport (MT) and the conjugated dye present in serum. Results prove that the MT of BSP is independent of the enzyme activity, but is correlated to the conjugated BSP present in serum during the first perfusion. The enzyme activity, the MT of BSP and BSP conjugated rare in serum are not related to the liver lesion stage. From the analysis of our results we conclude that in the beginning the BSP conjugated proportion is determined by the enzyme activity which is not a restrictive factor of the BSP maximal transport.
Serra
M A
MA
Caballero
A
A
Aparisi
L
L
Rodrigo
J M
JM
Del Olmo
J A
JA
Ferrando
J
J
Wassel
A H
AH
Reig
G
G
Bixquert
M
M
D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013448:Sulfobromophthalein / Q000493:pharmacokinetics*
D013448:Sulfobromophthalein; D005982:Glutathione Transferase
Actividad hepática de la glutatión transferasa y metabolismo de la bromosulfotaleína.