Chemoattractants produced by ocular cells induce trabecular meshwork cell migration.
Media conditioned by bovine corneal endothelium and scleral fibroblasts were found to induce the migration of bovine trabecular meshwork cells. The migrational activity had both chemokinetic (stimulated random motion) and chemotactic (directional migration) components. That produced by corneal endothelial cells had a markedly more potent effect. The relevance of these in vitro studies is discussed. Biochemically stimulated migration and loss of meshwork cells may be involved in the pathogenesis of glaucoma.
Calthorpe
C M
CM
Institute of Ophthalmology, London.
Grierson
I
I
Hitchings
R A
RA
D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000096:biosynthesis*; D004728:Endothelium, Corneal / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D012590:Sclera / Q000166:cytology; D014129:Trabecular Meshwork / Q000166:cytology*
D002630:Chemotactic Factors