Influence of beta-casomorphin derivatives on chemically and electrically induced seizures.
Derivatives of beta-casomorphin(1-5) at a dose level of 1 mumol/kg body weight were tested for their influence on pentylenetetrazol, picrotoxin, or electrically induced seizures after subcutaneous injection in mice. Tyr-Pro-Phe-D-Pro-Gly was found to facilitate pentylenetetrazol-evoked seizures, whereas desTyr derivatives Pro-Phe-D-Pro-Gly and Pro-Phe-Pyr exhibited anticonvulsant properties against those convulsions. The tripeptide was effective only 10 min after application. The beta-casomorphin derivative Pro-D-Phe-Pro-Gly was effective against electrically induced seizures. The protective action of this tetrapeptide lasted for about 5 h. Additionally, we tested the influence of orally administered Pro-Phe-D-Pro-Gly on pentylenetetrazol-induced seizures and Pro-D-Phe-Pro-Gly on electrically induced seizures. Both peptides were effective at a dose of 5 mumol/kg body weight.
Becker
A
A
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, GDR.
Grecksch
G
G
Matthies
H
H
D000595:Amino Acid Sequence; D000818:Animals; D000927:Anticonvulsants; D003292:Convulsants; D004357:Drug Synergism; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010433:Pentylenetetrazole; D010446:Peptide Fragments / Q000494:pharmacology; D010852:Picrotoxin; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*
D000927:Anticonvulsants; D003292:Convulsants; D004723:Endorphins; D010433:Pentylenetetrazole; D010446:Peptide Fragments; D010852:Picrotoxin; C021968:beta-casomorphins; C059556:beta-casomorphin, des-Tyr-