Induction and modulation of interleukin 1 production by defined partial structures of lipopolysaccharide.
Bacterial lipopolysaccharides (LPS) consist of a hydrophilic heteropolysaccharide component and a covalently linked hydrophobic lipid portion termed lipid A. Lipid A is responsible for most of the toxic and immunoregulatory effects of LPS. In studying the structure-function relationship of lipid A partial structures we now report that certain synthetic analogues, with themselves being biologically "inactive", exert immunomodulating effects on LPS-induced Interleukin 1 production in vitro.
Flad
H D
HD
Forschungsinstitut Borstel, Germany.
Feist
W
W
Wang
M H
MH
Brade
H
H
Rietschel
E T
ET
Ulmer
A J
AJ
D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D006017:Glycolipids / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood*; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology
D006017:Glycolipids; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; C044283:lipid X