Primary coronary artery dissection possibly related to drug hypersensitivity in a male.
Primary coronary artery dissection is rare, usually affects females (greater than 85%), and has most often affected the left anterior descending coronary artery. The authors report a case that is unusual in four respects: the patient was male, the involved artery was a marginal branch of the circumflex, the resulting small infarct ruptured, and most importantly, the patient had recently experienced a drug hypersensitivity reaction. The microscopic finding of a heavy eosinophil and mast cell infiltrate around the dissected artery may indicate that dissection occurred as a result of hypersensitivity angiitis of the vasa vasorum, as has previously been suggested in the literature.
Saunders
S L
SL
Department of Pathology, Kingston General Hospital, Ontario.
Ford
S E
SE
D000784:Aortic Dissection / Q000139:chemically induced* / Q000473:pathology; D003323:Coronary Aneurysm / Q000139:chemically induced* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000150:complications*; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000009:adverse effects; D008875:Middle Aged; D011802:Quinidine / Q000009:adverse effects
D008801:Mexiletine; D011802:Quinidine