Treatment of acute toxoplasmosis with oral clindamycin.
The combination of pyrimethamine and clindamycin, both administered orally, was evaluated for initial and maintenance therapy of toxoplasmosis in eight AIDS patients who were either allergic to sulfonamides or unresponsive to standard therapy. Symptomatic and neuroradiographic improvement occurred in the majority of patients. The regimen was well tolerated and associated with minimal toxicity, and appeared to be an effective alternative to standard therapy.
Rolston
K V
KV
Department of Medical Specialities, University of Texas-M.D. Anderson Cancer Center, Houston 77030.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction; D014123:Toxoplasmosis / Q000150:complications / Q000188:drug therapy*
D002981:Clindamycin; D011739:Pyrimethamine