title: Influence of no-donor (SIN-1) on functions of inflammatory cells.
abstract: NO-donor SIN-1 (0.01-1.0 mM) dose-dependently inhibited the basal and FMLP (30.0 mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Interleukin-2 production by T-hybridomas. I-123 LDL binding to human lymphocytes was inhibited by Iloprost (1 mM) but activated by SIN-1 (0.3 mM). We conclude that beside the smooth muscle cells and platelets the blood inflammatory/immune cells are under the PGI2/NO control, however, the precise regulation as well as physiological importance need further investigation.
authors.affiliation: Chair of Pharmacology, Institute of Microbiology Copernicus Academy of Medicine, Cracow, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Dembińska-Kieć
authors.forename: A
authors.initials: A
authors.lastname: Zmuda
authors.forename: J
authors.initials: J
authors.lastname: Marcinkiewicz
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
authors.forename: R J
authors.initials: RJ
authors.lastname: Gryglewski
mesh_terms: D000818:Animals; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D006825:Hybridomas / Q000502:physiology; D007249:Inflammation / Q000473:pathology*; D007376:Interleukin-2 / Q000096:biosynthesis; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D007376:Interleukin-2; D008077:Lipoproteins, LDL; C002385:linsidomine; D008981:Molsidomine; D005966:Glucuronidase