title: [Central regulation of gastrointestinal motility and secretion].
abstract: Gastrointestinal motility and secretions are regulated by cerebral nuclei via autonomic efferents in a coordinated fashion. At rest, vagal activity dominates while during different forms of stress the activated sympathetic nervous system markedly modulates secretions and motility. Expression of unique neuropeptides in distinct CNS regions facilitates the differentiated regulation of visceral functions. For example, corticotropin-releasing factor regulates the homeostatic pattern of visceral functions during stress. Furthermore, thyrotropin-releasing hormone accounts for parasympathetic activity while calcitonin gene related peptide predominantly accounts for sympathetic modulation of gastrointestinal motility and secretions. These neuropeptides coordinate visceral functions producing integrated motor and secretory responses that facilitate diverse digestive processes.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093-0648.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lenz
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001341:Autonomic Nervous System / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007419:Intestinal Secretions / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology
chemical_list: D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide
vernacular_title: Zentrale Regulation gastrointestinaler Motilität und Sekretion.