title: Characterization of the solution degradation products of histrelin, a gonadotropin releasing hormone (LH/RH) agonist.
abstract: The degradation products of histrelin (1, less than Glu-His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt) were determined in aqueous solution at pH 5.4 and 87 degrees C over an 18-day period (47% degradation). These degradation products (2-5) resulted from the cleavage of less than Glu-His and Trp-Ser peptide bonds, His-Trp diketopiperazine formation, and racemization of serine and histidine residues.
authors.affiliation: R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602.
authors.forename: A R
authors.initials: AR
authors.lastname: Oyler
authors.forename: R E
authors.initials: RE
authors.lastname: Naldi
authors.forename: J R
authors.initials: JR
authors.lastname: Lloyd
authors.forename: D A
authors.initials: DA
authors.lastname: Graden
authors.forename: C J
authors.initials: CJ
authors.lastname: Shaw
authors.forename: M L
authors.initials: ML
authors.lastname: Cotter
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry; D007263:Infusions, Parenteral; D008969:Molecular Sequence Data; D012996:Solutions
chemical_list: D012996:Solutions; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin