MDL 72222 (a selective 5-HT3 receptor antagonist) prevents stimulation of intrapulmonary C fibres by pulmonary embolization in anaesthetized rabbits.
We have investigated the effects of the intravenous administration of 5-hydroxytryptamine upon the discharge frequency of pulmonary stretch receptors, irritant receptors and C fibres. Only C fibres were stimulated by this autacoid. MDL 72222 a selective 5-HT3 receptor antagonist blocks the C fibre stimulation by 5-hydroxytryptamine. It also blocks the C fibre response to miliary pulmonary embolism. These data confirm the hypothesis that 5-hydroxytryptamine is the humoral link between pulmonary embolism and tachypnoea.
Kay
I S
IS
School of Health Sciences, Liverpool Polytechnic.
Armstrong
D J
DJ
D000818:Animals; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D011655:Pulmonary Embolism / Q000503:physiopathology*; D011661:Pulmonary Stretch Receptors / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology*
D012702:Serotonin Antagonists; D014326:Tropanes; D012701:Serotonin; C042253:bemesetron