title: Predicted dose-volume isoeffect curves for stereotactic radiosurgery with the 60Co gamma unit.
abstract: Mathematical models were developed to predict tolerance of brain tissue to stereotactic radiosurgery. The use of these formulas for predicting symptomatic brain necrosis from stereotactic radiosurgery with the 60Co gamma unit is discussed. Predicted dose-response curves for different collimator sizes were calculated. Dose-volume isoeffect curves for a 3% risk of brain necrosis from a single fraction radiosurgery were then derived. Dose-volume isoeffect curves for combinations of fractionated whole brain irradiation with radiosurgery boosts were also calculated. The predicted dose-volume isoeffect curves provide useful tolerance guidelines for the practice of stereotactic radiosurgery.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
authors.forename: A
authors.initials: A
authors.lastname: Wu
authors.forename: A
authors.initials: A
authors.lastname: Kalend
mesh_terms: D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008432:Mathematical Computing; D008954:Models, Biological; D009336:Necrosis / Q000209:etiology; D011832:Radiation Injuries / Q000473:pathology; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D013238:Stereotaxic Techniques
chemical_list: D003037:Cobalt Radioisotopes