[The characteristics of glutathione reductase distribution and activity in the liver of adult rats subjected to paraquat action in the embryonic period].
Paraquat action on glutathione reductase activity and intratissue distribution in the liver of intact rats and also in the animals antenatally treated with the given herbicide was studied by some biochemical and histochemical methods. It has been ascertained that paraquat injection into intact animals promotes the increase in the intracellular enzyme level, development of glutathione reductase staining of hepatocyte nuclei, diffuse distribution of the staining along the lobe. In rats antenatally treated with paraquat acute priming does not induce glutathione reductase. In these conditions a mosaic distribution of this enzyme is observed in the hepatic tissue.
Semeniuk
A V
AV
Glazyrin
A L
AL
Kolesnikov
S I
SI
Salganik
R I
RI
D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005980:Glutathione Reductase / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010269:Paraquat / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D005980:Glutathione Reductase; D010269:Paraquat
Osobennosti raspredeleniia i aktivnosti glutationreduktazy v pecheni vzroslykh krys, podvergnutykh deĭstviiu parakvata v émbrional'nyĭ period.