Effects of controlled liver injury and ethanol pretreatment on monoethylglycine xylidide formation in the rat.
Measuring the monoethylglycine xylidide (MEGX) serum level 15-30 min after intravenous administration of lidocaine has been shown to be an accurate predictor of early success in liver transplants. This study evaluates the changes in the MEGX formation test associated with changes in liver mass and ethanol pretreatment in a rat model. Mean MEGX levels were significantly higher for the sham-operated group versus each of the partially hepatectomized groups at 15, 30, and 45 min after injection. No differences between mean MEGX levels for either of the surgically treated groups could be distinguished. Ethanol pretreatment and body weight had no effect on MEGX levels at any of the time points tested in this model.
Druckenbrod
R W
RW
University of Cincinnati Medical Center, Colleges of Pharmacy and Medicine, Ohio.
Mendenhall
C L
CL
Myre
S A
SA
Stanberry
E A
EA
Schroeder
T J
TJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000378:metabolism; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D006207:Half-Life; D006498:Hepatectomy; D007208:Indocyanine Green; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis
D002110:Caffeine; D000431:Ethanol; D008012:Lidocaine; C001173:monoethylglycinexylidide; D007208:Indocyanine Green