title: On the identification of a conjugated diene component of duodenal bile as 9Z,11E-octadecadienoic acid.
abstract: The lipid free radical marker, termed diene conjugation, in secretin-stimulated human bile obtained from the duodenum, was shown by high performance liquid chromatography and capillary gas chromatography-mass spectrometry, to be due mainly to 9Z,11E-octadecadienoic acid. The lack of evidence for possible conjugated diene isomers argues for an enzymatic origin of this product rather than being due to a random free radical mechanism, as is usually assumed.
authors.affiliation: Department of Chemistry, University of Manchester, England.
authors.forename: G N
authors.initials: GN
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Taj
authors.forename: J M
authors.initials: JM
authors.lastname: Braganza
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated; D012633:Secretin / Q000494:pharmacology
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; D005609:Free Radicals; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D012633:Secretin; C046938:9,11-linoleic acid