Characterization of the solution degradation products of histrelin, a gonadotropin releasing hormone (LH/RH) agonist.
The degradation products of histrelin (1, less than Glu-His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt) were determined in aqueous solution at pH 5.4 and 87 degrees C over an 18-day period (47% degradation). These degradation products (2-5) resulted from the cleavage of less than Glu-His and Trp-Ser peptide bonds, His-Trp diketopiperazine formation, and racemization of serine and histidine residues.
Oyler
A R
AR
R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602.
Naldi
R E
RE
Lloyd
J R
JR
Graden
D A
DA
Shaw
C J
CJ
Cotter
M L
ML
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry; D007263:Infusions, Parenteral; D008969:Molecular Sequence Data; D012996:Solutions
D012996:Solutions; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin