title: Cold agglutinins in haemophiliac boys infected with HIV.
abstract: Eleven haemophiliac boys infected with HIV were screened for irregular red cell antibodies and were compared with nine haemophiliac boys who did not have antibodies to HIV. Seven (64%) of the children who had antibodies to HIV also had cold agglutinins, mostly of anti-I specificity, compared with one (11%) of those who did not have antibodies to HIV. The children with antibodies to HIV and cold agglutinins had a significantly increased mean IgM concentration. The presence of cold agglutinins was not correlated with T4 lymphocyte count, symptoms of HIV infection, serum beta 2 microglobulin concentrations, concentrations of IgG or IgA, or with the evidence of past infection with cytomegalovirus or Epstein-Barr virus.
authors.affiliation: Royal Liverpool Children's Hospital, Alder Hey.
authors.forename: P H
authors.initials: PH
authors.lastname: Bolton-Maggs
authors.forename: P D
authors.initials: PD
authors.lastname: Rogan
authors.forename: J K
authors.initials: JK
authors.lastname: Duguid
authors.forename: K J
authors.initials: KJ
authors.lastname: Mutton
authors.forename: L M
authors.initials: LM
authors.lastname: Ball
mesh_terms: D000293:Adolescent; D000373:Agglutinins / Q000276:immunology*; D001789:Blood Group Antigens / Q000276:immunology; D002648:Child; D003450:Cryoglobulins; D015658:HIV Infections / Q000209:etiology / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male
chemical_list: D000373:Agglutinins; D001789:Blood Group Antigens; D003450:Cryoglobulins; D007048:I Blood-Group System; D007075:Immunoglobulin M; C029443:cold agglutinins