Protective effects of gamma-hydroxybutyrate on alloxan induced diabetes in mice.
Gamma-hydroxybutyrate (GHB) administered to mice prior to alloxan antagonizes its diabetogenic action in a dose dependent fashion and up to 96 hours after injection. Results are discussed on the basis of free radical formation by alloxan and of the metabolic property of GHB which is known to increase the rate of operation of the pentose phosphate pathway.
Pierrefiche
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Laboratoire d'Eutonologie, Hopital Boucicaut, Paris, France.
Topall
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Henriet
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Laborit
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H
D000496:Alloxan / Q000037:antagonists & inhibitors; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000517:prevention & control*; D005609:Free Radicals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010427:Pentose Phosphate Pathway / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology*
D001786:Blood Glucose; D005609:Free Radicals; D000496:Alloxan; D012978:Sodium Oxybate; D005954:Glucosephosphate Dehydrogenase