Effects of ethanol inhalation on EEG in rats.
Effects of ethanol on duration of stages of sleep-wake cycle and EEG power spectra were measured during a 2-h exposure in a dynamic inhalational chamber in rats. Rats were exposed to one of four graded concentrations (approx. 100, 400, 800 and 1600 ppm) of ethanol on different days. Ethanol was found to increase the duration of waking (W) with a decrease in duration of rapid eye movement (REM) sleep at 100 and 400 ppm. No effect was observed at 800 and 1600 ppm on the stages of sleep-wake cycle or at 100-1600 ppm on EEG power spectra from the somatosensory or visual cortices. Results indicate that ethanol administered by inhalation could produce arousal action at low doses, but did not have any effect on EEG power spectrum at the concentrations used.
Ghosh
T K
TK
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059.
Copeland
R L
RL
Pradhan
S N
SN
D000280:Administration, Inhalation; D000818:Animals; D004569:Electroencephalography; D004576:Electromyography; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012890:Sleep / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects; D014793:Visual Cortex / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D000431:Ethanol