Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA.
Scavenger receptor-mediated uptake of acetylated low density lipoprotein-derived cholesterol by peritoneal mouse macrophages resulted in decreased activity of the malonyl-CoA inhibitable carnitine palmitoyltransferase and a decrease in the sensitivity of this enzyme to inhibition by malonyl-CoA.
Kashfi
K
K
Department of Pharmacology, College of Medicine, University of Tennessee, Memphis.
Dory
L
L
Cook
G A
GA
D000818:Animals; D001692:Biological Transport; D002334:Carnitine O-Palmitoyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D008316:Malonyl Coenzyme A / Q000494:pharmacology*; D051379:Mice
D002788:Cholesterol Esters; D008077:Lipoproteins, LDL; D008316:Malonyl Coenzyme A; D002784:Cholesterol; D002334:Carnitine O-Palmitoyltransferase