Mechanisms of protection against damage mediated by the Maillard reaction in aging.
In order to prevent or escape the ongoing damage to proteins and DNA resulting from amino-carbonyl reactions, the organism has to have powerful defense mechanisms. If the Maillard reaction played a role in determining longevity among mammalian species, one would expect protective mechanisms to be more developed in long- versus short-lived species. This article summarizes current knowledge in this field, and discusses the concept of anti-Maillard mechanisms as a basis for the genetic regulation of molecular damage by reducing sugars in aging and diabetes.
Monnier
V M
VM
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Sell
D R
DR
Nagaraj
R H
RH
Miyata
S
S
D000375:Aging / Q000502:physiology*; D000588:Amines / Q000494:pharmacology; D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology; D005786:Gene Expression Regulation; D005947:Glucose / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D015416:Maillard Reaction / Q000187:drug effects; D051381:Rats
D000588:Amines; D005947:Glucose