Plasma thiobarbituric acid reactive substances a predictive marker of cerebral ischemia in patients at high risk?
The clinical meaning of high values of blood lipid peroxides, assessed as thiobarbituric acid reactive substances (TBA-RS), was investigated in 19 selected high risk patients with transient ischemic attacks (TIA). Patients were checked every 3-6 months and followed-up for 3 years. 8 patients experienced further vascular episodes, 4 having minor stroke and 4 TIA; one of the latter died from myocardial infarction. Unlike blood cholesterol and glucose. TBA-RS values discriminated patients with vascular episodes: they, indeed, showed significant higher values of TBA-RS. Discriminant analysis further indicated that TBA-RS levels differentiate patients with and without vascular accidents, suggesting that high blood values of lipid peroxides could represent a predictive sign of vascular ischemia.
Alessandri
C
C
Andrea Cesalpino Foundation, La Sapienza University, Rome.
Germani
M
M
Censi
C
C
Rudelli
G
G
Iuliano
L
L
Servi
M
M
Ghiselli
A
A
Violi
F
F
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis*; D002784:Cholesterol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000175:diagnosis*; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis*; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D013858:Thiobarbiturates / Q000493:pharmacokinetics*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008054:Lipid Peroxides; D013858:Thiobarbiturates; D014280:Triglycerides; D002784:Cholesterol; C029684:thiobarbituric acid