title: Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
abstract: A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.
authors.affiliation: Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.
authors.forename: W B
authors.initials: WB
authors.lastname: Cowden
authors.forename: P K
authors.initials: PK
authors.lastname: Halladay
authors.forename: R B
authors.initials: RB
authors.lastname: Cunningham
authors.forename: N H
authors.initials: NH
authors.lastname: Hunt
authors.forename: I A
authors.initials: IA
authors.lastname: Clark
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical; D005415:Flavins / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D005415:Flavins