Central nervous system action of endothelin-3 to inhibit water drinking in the rat.
Endothelin-3, a vasoconstrictor peptide produced not only in endothelial cells but also within the brain interstitium in magnocellular neurons of the hypothalamo-neurohypophysial system, exerted significant, dose-related, inhibitory effects on water intake when administered into the third cerebroventricle of rats exposed to exogenous and endogenous stimuli for drinking. Passive immunoneutralization of endogenous endothelin-3 accentuated water drinking in response to angiotensin II administration suggesting a physiological role for the peptide in the central control of fluid and electrolyte homeostasis.
Samson
W K
WK
Department of Anatomy and Neurobiology, University of Missouri School of Medicine, Columbia 65212.
Skala
K
K
Huang
F L
FL
Gluntz
S
S
Alexander
B
B
Gómez-Sánchez
C E
CE
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D016232:Endothelins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D000804:Angiotensin II