title: 1H spectroscopic imaging using a spectral-spatial excitation pulse.
abstract: Excellent water suppression is required to perform in vivo 1H spectroscopic experiments. However water suppression is difficult due to both B0 and RF inhomogeneities. These inhomogeneities are particularly troublesome in spectroscopic imaging experiments where water suppression is required throughout some large region of interest. In this paper, we propose the use of spectral-spatial excitation pulses for such experiments. These two-dimensional pulses are shown to provide water suppression that is insensitive to a range of B0 and RF variations while simultaneously providing spatial localization. Experimental results including images (with voxel volumes ranging from 3.4 to 1.5 cc) of various brain metabolites from both a normal volunteer and a patient with a metastatic lung carcinoma are presented.
authors.affiliation: Magnetic Resonance Systems Research Laboratory, Stanford University, California 94305.
authors.forename: D
authors.initials: D
authors.lastname: Spielman
authors.forename: C
authors.initials: C
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Macovski
authors.forename: D
authors.initials: D
authors.lastname: Enzmann
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy