title: Serological responses of rams to a Brucella ovis-vitamin E adjuvant vaccine.
abstract: Rams which were vaccinated at 6-8 months of age with a water-in-oil Brucella ovis-vitamin E adjuvant vaccine had significantly higher serum antibody levels than rams vaccinated with a commercial B. ovis bacterin or B. melitensis Rev 1. The adjuvant vaccine did not cause abscesses at the site of injection as some water-in-oil emulsions do. Two years after vaccination, the vitamin E adjuvant-vaccinated rams had higher antibody level than the other groups. This was most likely due to a secondary response to naturally occurring infection with B. ovis.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins 80523.
authors.forename: R P
authors.initials: RP
authors.lastname: Tengerdy
authors.forename: E
authors.initials: E
authors.lastname: Ameghino
authors.forename: H
authors.initials: H
authors.lastname: Riemann
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002002:Brucella / Q000276:immunology; D002004:Brucella Vaccine / Q000276:immunology*; D002006:Brucellosis / Q000517:prevention & control / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D004823:Epididymitis / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D012756:Sheep / Q000276:immunology*; D012757:Sheep Diseases / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D002004:Brucella Vaccine; D014810:Vitamin E