[Effect of ionol on the activity of oxidative enzymes and ultrastructure of myocardial hematoparenchymatous barrier in hypoxic hypoxia].
Experiments were conducted on 112 adult male Wistar rats to study the effect of preliminary ionol administration on the activity of oxidation enzymes and ultrastructure of the hematoparenchymatous barrier (HPB) in the myocardium in acute and prolonged hypoxic hypoxia. It is shown that ionol was conducive to minimal damage of HPB ultrastructures in hypoxia and had a positive effect on oxidation metabolism of the myocardium: removed inhibition of isocitrate and malate dehydrogenase, activated the key enzymes of transport of reduction equivalents in the mitochondria.
Man'kovskaia
I N
IN
Seredenko
M M
MM
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D002084:Butylated Hydroxytoluene
Vliianie ionola na aktivnost' okislitel'nykh fermentov i ul'trastrukturu gematoparenkhimatoznogo bar'era v miokarde pri gipoksicheskoĭ gipoksii.