Cytogenetic studies in male infertility: a review.
Among those factors known to influence spermatogenesis, chromosomal aberration is perhaps the best known. A review of the literature on mitotic studies in infertile men showed that 12% of the azoospermic and severe oligozoospermic (sperm count less than 10 x 10(6)/ml) males had a karyotypic abnormality; they mainly consisted of an XXY constitution or a Robertsonian or reciprocal translocation. A similar review on meiotic studies revealed that 8% of the infertile males had some kind of cytogenetic error. Therefore, mitotic and meiotic studies are indicated in males with severe gamete impairment when the other possible causes have been eliminated.
De Braekeleer
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M
Group in Human Genetics, SOREP, Université du Quebec à Chicoutimi, Canada.
Dao
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TN
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics