The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP.
Male Wistar rats were intraventricularly injected with 2-deoxy-D-galactose (do-gal), a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. Do-gal was found to have no influence on the monosynaptically evoked field potential (MEFP) recorded in the dentate gyrus upon stimulation of the perforant pathway. However, hippocampal long-term potentiation (LTP) induced in do-gal-pretreated animals by fractionated tetanization of the perforant pathway declined to control levels 2 h after tetanization, whereas it remained constant for 24 h in saline-treated rats. Similar effects were observed in the CA1 region of hippocampal slices. The results indicate a participation of fucosylated macromolecules in the maintenance of LTP. The possible significance of processes involved in LTP for memory formation is discussed.
Krug
M
M
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
Jork
R
R
Reymann
K
K
Wagner
M
M
Matthies
H
H
D000647:Amnesia; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004334:Drug Administration Schedule; D005071:Evoked Potentials / Q000187:drug effects*; D005690:Galactose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D008297:Male; D011712:Pyramidal Tracts / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
C019327:2-deoxy-lyxo-hexose; D005690:Galactose