[Mitochondrial antigens and their antibodies].
In the mitochondria nine antigens and their corresponding antibodies are already known. They can be subdivided in three groups. The first one (M2-M4-M6-M8) appears during the evolution of primary biliary cirrhosis. The antibody against M2 is practically pathognomic for this disease. The M9-antibody is found in PBC with a slow and favourable evolution. The antibodies against M4-M8 are signs of a worse prognosis and a more rapid evolution into terminal cirrhosis. The second group is connected with infections and collagen diseases. The M1-antibody is directed against cardiolipin and diagnostic for syphilis. The M5-antibody appears in definite collagenoses. The M7-antibody is found in certain forms of acute and chronic cardiomyopathy. The third group of antibodies is induced by drugs: the anti-M3 by Venocuran containing a.o. phenopyrazone and the anti-M6 by Iproniazid. The role of the antigens and their antibodies concerning the aetiology and pathogenesis of the relevant diseases, especially primary biliary cirrhosis, is not known.
De Groote
J
J
Afdeling Hepatologie, Katholieke Universiteit Leuven, UZ Gasthuisberg, Belgium.
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D003095:Collagen Diseases / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008928:Mitochondria / Q000276:immunology*; D011379:Prognosis
D001323:Autoantibodies; D001324:Autoantigens
De mitochondriale antigenen en hun antilichamen.