title: Destructive lesions in demyelinating disease.
abstract: Three cases are presented in which clinical and radiological features suggested the diagnosis of glioma but surgical biopsy revealed a demyelinating process, with tissue destruction and cyst formation in two. One patient had clinically definite multiple sclerosis. Two had probable acute disseminated encephalomyelitis. Treatment with high dose steroids is appropriate when there is clinical or investigative evidence to suggest the presence of demyelinating disease, before deciding on biopsy.
authors.affiliation: Multiple Sclerosis NMR Research Group, Institute of Neurology, London, UK.
authors.forename: B D
authors.initials: BD
authors.lastname: Youl
authors.forename: A G
authors.initials: AG
authors.lastname: Kermode
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: T
authors.initials: T
authors.lastname: Révész
authors.forename: F
authors.initials: F
authors.lastname: Scaravilli
authors.forename: R O
authors.initials: RO
authors.lastname: Barnard
authors.forename: F J
authors.initials: FJ
authors.lastname: Kirkham
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: D
authors.initials: D
authors.lastname: Kingsley
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
mesh_terms: D000293:Adolescent; D000328:Adult; D001253:Astrocytes / Q000473:pathology; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004679:Encephalomyelitis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination; D014057:Tomography, X-Ray Computed