title: Unusual forms of insulin resistance.
abstract: Insulin resistance is an important feature in the pathogenesis of non-insulin-dependent diabetes mellitus. Some rare patients have syndromes associated with a severe form of insulin resistance, usually involving acanthosis nigricans and, in premenopausal females, hyperandrogenism. This review discusses two of the causes of insulin resistance: mutations in the insulin receptor gene and autoantibodies directed against the insulin receptor.
authors.affiliation: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: S I
authors.initials: SI
authors.lastname: Taylor
authors.forename: D
authors.initials: D
authors.lastname: Accili
authors.forename: A
authors.initials: A
authors.lastname: Cama
authors.forename: E
authors.initials: E
authors.lastname: Imano
authors.forename: H
authors.initials: H
authors.lastname: Kadowaki
authors.forename: T
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D000052:Acanthosis Nigricans / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics* / Q000276:immunology; D013577:Syndrome; D014770:Virilism / Q000209:etiology
chemical_list: D001786:Blood Glucose; D011972:Receptor, Insulin