Neurotensin selectively antagonizes apomorphine-induced stereotyped climbing.
In order to better characterize the neuroleptic properties of neurotensin, the dose-related effects of the peptide on stereotyped climbing, sniffing and licking induced by 0.6 mg/kg apomorphine were examined. The following doses of the peptide were injected intraventricularly 30 min prior to apomorphine administration: 0.9, 3.75, 30.0 and 60 micrograms. Results indicate that, whereas oro-facial stereotypies remained unaffected by the peptide, stereotyped climbing was significantly decreased with the two largest doses of neurotensin. These findings indicate that the profile of neurotensin's neurobehavioral effects is more akin to that of atypical than typical neuroleptics.
Jolicoeur
F B
FB
Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
Gagne
M A
MA
Rivest
R
R
Drumheller
A
A
St-Pierre
S
S
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D009496:Neurotensin; D001058:Apomorphine