Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.
Clostridium perfringens theta-toxin was shown to lyse target erythrocytes by a colloid-osmotic mechanism. Analysis showed the onset of lysis of erythrocytes by theta-toxin could be temporarily stabilized with 0.3 M sucrose. Flow cytometry analysis of the size distribution of theta-toxin-treated erythrocytes showed swelling of the erythrocytes prior to lysis.
Harris
R W
RW
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Sims
P J
PJ
Tweten
R K
RK
D001427:Bacterial Toxins / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000472:pathogenicity*; D003102:Colloids; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D005434:Flow Cytometry; D006460:Hemolysin Proteins; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D009994:Osmolar Concentration
D001427:Bacterial Toxins; D003102:Colloids; D006460:Hemolysin Proteins; C020452:Clostridium perfringens theta-toxin