title: The presence of urinary cellular sediment and albuminuria in newspaper pressworkers exposed to solvents.
abstract: To investigate the relationship between exposure to organic solvents and the presence of increased urinary cellular sediment, we conducted a cross-sectional study of 215 newspaper pressroom workers who were exposed to solvent and lubricant mixtures. Thirty-two compositors were surveyed as referents. Industrial hygiene measurements showed low-level airborne exposures to organic solvents (primarily naphthas) and minimal airborne exposure to glycol ethers. There was a high prevalence of solvent-related dermatitis indicating there was significant dermal exposure to these substances. Pressworkers were exposed to solvent mixtures that were associated with dose-related increases in leukocyturia alone or in urinary cellular sediment (erythrocyturia and/or leukocyturia). The presence of urinary cellular sediment was associated with increasing frequency of use of five particular organic solvent mixtures. These results suggest that the increase in urinary cellular sediment may be due, at least in part, to the effects of solvents on the kidney. Consistent with this hypothesis, 16% of pressmen and no compositors were found to have primarily low-grade albuminuria detectable by dipstick. Workers with urinary cellular sediment were significantly more likely to have detectable albuminuria. Albuminuria was more likely to occur with increased frequency of use of four particular solvent mixtures. The presence of urinary cellular sediment was less likely to occur with occasional use of analgesics suggesting a possible etiologic role for acute or chronic urinary tract inflammation.
authors.affiliation: Occupational Health Program, Harvard School of Public Health, Boston, MA 02115.
authors.forename: D M
authors.initials: DM
authors.lastname: Hashimoto
authors.forename: K T
authors.initials: KT
authors.lastname: Kelsey
authors.forename: T
authors.initials: T
authors.lastname: Seitz
authors.forename: H A
authors.initials: HA
authors.lastname: Feldman
authors.forename: B
authors.initials: B
authors.lastname: Yakes
authors.forename: D C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000139:chemically induced*; D000473:Alkanes / Q000009:adverse effects; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009511:New England; D009784:Occupational Diseases / Q000139:chemically induced*; D009822:Oils, Volatile / Q000009:adverse effects; D010578:Petroleum / Q000009:adverse effects; D011327:Printing; D012044:Regression Analysis; D012997:Solvents / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D014556:Urine / Q000166:cytology*
chemical_list: D000473:Alkanes; D009822:Oils, Volatile; D010578:Petroleum; D012997:Solvents; C004544:naphtha