Abrogation of dominant glucose intolerance in SJL mice by a growth hormone transgene.
Glucose tolerance was studied in transgenic mice (SJL x C57BL/6) expressing human GH under the control of a housekeeping promoter. Parental SJL mice were found to harbour a dominant allele, termed here glid, determining glucose intolerance in pure-bred animals and in F1 hybrids with glucose-tolerant C57BL/6 mice. Blood glucose levels in transgenic SJL x C57BL/6 hybrid mice were well controlled following glucose challenge, whereas non-transgenic hybrids failed to control their glucose adequately. Pancreatic morphology was normal in all animals. In confirmation of a physiological role for GH in glucose regulation. GH-deficient lit/lit mice were pathologically sensitive to glucose.
Bchini
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LGME-CNRS and U184-INSERM, Strasbourg, France.
Mehtali
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Lathe
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D000483:Alleles; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005799:Genes, Dominant; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000235:genetics* / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D013045:Species Specificity
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone