[The action of befol and its derivatives on monoamine oxidase of different origins].
The effect on deamination of serotonine, dopamine, tiramine and 2-phenylamine of benzamide derivatives befol, moclobemide and LIS-641 was studied. Befol and moclobemide are inhibitors of serotonine deaminating activity of MAO. The different sensitivity of this activity to the effect of the benzamide derivatives in beef or rat brain and human placenta was noted. The inhibition was more distinct in tissue homogenate than in corresponding mitochondrial fractions.
Gol'dina
O A
OA
Moskvitina
T A
TA
Gankina
E M
EM
Kirkel'
A Z
AZ
Kamyshanskaia
N S
NS
Lopatina
K I
KI
Sokolova
T V
TV
Zagorevskiĭ
V A
VA
Val'dman
A V
AV
Gorkin
V Z
VZ
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002417:Cattle; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D020912:Moclobemide; D008995:Monoamine Oxidase / Q000187:drug effects* / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects / Q000201:enzymology; D051381:Rats
D000928:Antidepressive Agents; D001549:Benzamides; D009025:Morpholines; C059049:befol; D008995:Monoamine Oxidase; D020912:Moclobemide
Deĭstvie befola i ego proizvodnykh na monoaminoksidazu razlichnogo proiskhozhdeniia.