title: [Bone marrow transplantation in congenital defects of immunity].
abstract: BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.
authors.affiliation: Clinica Pediatrica, Ospedale Civile, Brescia, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Porta
authors.forename: L D
authors.initials: LD
authors.lastname: Notarangelo
authors.forename: F
authors.initials: F
authors.lastname: Candotti
authors.forename: E
authors.initials: E
authors.lastname: Mazzolari
authors.forename: A
authors.initials: A
authors.lastname: Lanfranchi
authors.forename: A G
authors.initials: AG
authors.lastname: Ugazio
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005060:Europe; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000401:mortality / Q000628:therapy*
chemical_list: D006680:HLA Antigens
vernacular_title: Il trapianto di midollo osseo nei difetti congeniti dell'immunità.