Inner ear damage secondary to diabetes mellitus. I. Changes in adolescent SHR/N-cp rats.
The association between diabetes mellitus and hearing impairment has been debated in many previous studies. The spontaneous hypertensive/NIH-corpulent (SHR/N-cp) rat has been shown to be a unique genetic model for non-insulin-dependent diabetes mellitus. Seventeen diabetic and 17 control young male rats were divided into groups according to diet and phenotype. The rats were fed either 54% of sucrose or 54% starch diets for 3.5 months and killed at 5 months. The cochleas were fixed, decalcified, dissected, and stained for hair cell counting. A significant loss of outer hair cells was noted in the diabetic obese (SHR/N-cp) animals when compared with the control obese (LA/N-cp) animals in every group. Although no significant difference was noted between the diabetic obese (SHR/N-cp) animals receiving the starch and sugar diets, the diabetic obese (SHR/N-cp) animals were more severely affected than the nondiabetic lean (SHR/N-cp) rats.
Triana
R J
RJ
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill.
Suits
G W
GW
Garrison
S
S
Prazma
J
J
Brechtelsbauer
P B
PB
Michaelis
O E
OE
Pillsbury
H C
HC
D000818:Animals; D003051:Cochlea / Q000648:ultrastructure; D015834:Cochlear Diseases / Q000209:etiology* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006311:Hearing Disorders / Q000209:etiology* / Q000473:pathology; D008297:Male; D009765:Obesity / Q000150:complications; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013213:Starch / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage
D004040:Dietary Carbohydrates; D013395:Sucrose; D013213:Starch