title: Intrauterine pressures in labours induced by amniotomy and oxytocin or vaginal prostaglandin gel compared with spontaneous labour.
abstract: Uterine activity during the first stage of labour was measured by an intrauterine transducer in 22 women induced with intravaginal PGE2 gel, in 37 induced by amniotomy and intravenous oxytocin, and in nine women in spontaneous labour. The nulliparous women in the PGE2 gel group had a significantly longer pre-established phase of labour and a significantly shorter established phase than nulliparae induced by amniotomy and oxytocin. The mean levels of total uterine activity (kPas) during labour and the uterine activity integrals (kPas/15 min) were significantly lower in nulliparae induced with PGE2 gel than in those induced by amniotomy and oxytocin. These findings suggest that PGE2 gel has a positive, beneficial effect on cervical compliance during the pre-established phase, resulting in less myometrial effort during established labour. These effects were less evident in parous women, probably because of an innate lower cervical resistance due to their previous labours. Uterine activity patterns during the 4 h leading to full cervical dilatation in nulliparae were similar in labours induced with PGE2 gel and spontaneous labours, whereas labours induced by amniotomy and oxytocin exhibited a significantly different pattern. Expulsion of the fetus during normal labour is a function of both uterine contractions and a decrease in the cervical resistance and the data suggest that induction by PGE2 gel more closely mimics spontaneous labour, whereas the predominant effect of oxytocin is to stimulate myometrial activity.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Southampton Medical School.
authors.forename: R F
authors.initials: RF
authors.lastname: Lamont
authors.forename: S
authors.initials: S
authors.lastname: Neave
authors.forename: A C
authors.initials: AC
authors.lastname: Baker
authors.forename: P J
authors.initials: PJ
authors.lastname: Steer
mesh_terms: D000650:Amnion / Q000601:surgery*; D015232:Dinoprostone / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005782:Gels; D006801:Humans; D007262:Infusions, Intravenous; D007751:Labor, Induced; D010121:Oxytocin / Q000008:administration & dosage; D011247:Pregnancy; D011312:Pressure; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*; D014621:Vagina
chemical_list: D005782:Gels; D010121:Oxytocin; D015232:Dinoprostone