[The effect of finoptin on the metabolism and pharmacological action of cyclophosphane in vivo and in vitro].
Phynoptin (Ph) and cyclophosphamide (CP) gave rise to a type I spectral changes with liver microsomal fraction. KS were 15 microM and 2150 microM, respectively. Ph increases the concentration of NBP product(s) of CP and acrolein in the blood plasma of animals. Ph increases a toxicity of CP. LD50 was 388.0 +/- 13.9 mg/kg for CP and LD50 was 342.8 +/- 16.9 mg/kg for CP in combination with Ph. Ph changes a therapeutic action of CP in mice with hemocytoblastosis La. Pharmacokinetic interactions have been demonstrated between calcium antagonists Ph and CP.
Donenko
F V
FV
Chikvashvili
B Sh
BSh
Borovkova
N B
NB
Devichenskiĭ
V M
VM
Kabieva
A O
AO
Korneva
E N
EN
Telegin
L Iu
LIu
Shcherbakov
V M
VM
Letiagin
V P
VP
Moroz
L V
LV
D000818:Animals; D003520:Cyclophosphamide / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D007942:Leukemia, Experimental / Q000097:blood / Q000188:drug therapy / Q000401:mortality; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009368:Neoplasm Transplantation; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D003520:Cyclophosphamide; D014700:Verapamil
Vliianie finoptina na metabolizm i farmakologicheskoe deĭstvie tsiklofosfana in vivo i in vitro.