[Therapeutic trial with ivermectin in loiasis with medium and high microfilaremia].
Treatment with ivermectin at the dosage of 200 microgram/kg in 28 Congolese loiasis patients led to an important decrease of the microfilaremia on day 7, with a reduction of about 90% of the initial parasite load. However, no negativation was observed and, moreover, the parasitemia did not change from day 7 to day 14. Tolerance was quite good, but weak to moderate reactions, linked to the lysis of the microfilariae, were observed in one third of the patients with a microfilaremia greater or equal to 2,500/mm3.
Carme
B
B
Laboratoire de Parasitologie et Mycologie, CHU de Brazzaville, Congo.
Ebikili
B
B
Mbitsi
A
A
Copin
N
N
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008118:Loiasis / Q000188:drug therapy* / Q000469:parasitology; D008842:Microfilariae / Q000302:isolation & purification
D007559:Ivermectin
Essai thérapeutique de l'ivermectine au cours de la loase à moyenne et forte microfilarémie.