title: A comparison of the pharmacokinetic properties of streptokinase and anistreplase in acute myocardial infarction.
abstract: 1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations. 2. The two agents were found to have similar volumes of distribution (5.68 and 5.90 l), but SK was cleared significantly more rapidly than anistreplase, resulting in a shorter terminal phase half-life (0.61 vs 1.16 h) and a shorter mean residence time (0.76 vs 1.55 h).
authors.affiliation: Department of Medicine, University of Glasgow, Stobhill General Hospital.
authors.forename: J D
authors.initials: JD
authors.lastname: Gemmill
authors.forename: K J
authors.initials: KJ
authors.lastname: Hogg
authors.forename: J M
authors.initials: JM
authors.lastname: Burns
authors.forename: A P
authors.initials: AP
authors.lastname: Rae
authors.forename: F G
authors.initials: FG
authors.lastname: Dunn
authors.forename: R
authors.initials: R
authors.lastname: Fears
authors.forename: H
authors.initials: H
authors.lastname: Ferres
authors.forename: R
authors.initials: R
authors.lastname: Standring
authors.forename: H
authors.initials: H
authors.lastname: Greenwood
authors.forename: D
authors.initials: D
authors.lastname: Pierce
mesh_terms: D000368:Aged; D016255:Anistreplase / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009203:Myocardial Infarction / Q000378:metabolism*; D013300:Streptokinase / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D005343:Fibrinolytic Agents; D016255:Anistreplase; D013300:Streptokinase