Inhibitory effect of rat immunization with tularemia vaccine on the in vivo clastogenicity of 4 anthracycline antibiotics.
We studied the in vivo effect of rat immunization with tularemia live vaccine (TLV) on chromosomal aberrations (CA) induced in bone marrow cells by 4 anthracycline antibiotics. CA induced by adriamycin (ADR) and 4'-epiadriamycin (EADR) in rat bone marrow cells consisted mainly of chromatid breaks (approximately 90%), whereas lesions induced by aclacur (AC) and aclarubicin (ACR) consisted only of chromatid breaks. Preliminary cutaneous immunization of rats with TLV revealed significant suppression of CA induced by all 4 antibiotics. The present and previous results suggest that TLV may be a potent anticlastogenic factor.
Nersessian
A K
AK
V.A. Fanardjian Centre for Oncology Research, Yerevan, Armenia, U.S.S.R.
Zilfian
V N
VN
Koumkoumadjian
V A
VA
D015250:Aclarubicin / Q000633:toxicity; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004317:Doxorubicin / Q000633:toxicity; D015251:Epirubicin / Q000633:toxicity; D005604:Francisella tularensis / Q000276:immunology*; D007271:Injections, Intradermal; D008099:Liver / Q000378:metabolism; D008297:Male; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains
D000903:Antibiotics, Antineoplastic; D001428:Bacterial Vaccines; D015251:Epirubicin; D015250:Aclarubicin; D004317:Doxorubicin