title: [The effect of an extract from Cochlospermum angolense ("Burututu") on Plasmodium berghei in the mouse malaria suppression test].
abstract: Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.
authors.affiliation: Institut für Medizinische Mikrobiologie des Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, BRD.
authors.forename: W
authors.initials: W
authors.lastname: Presber
authors.forename: D K
authors.initials: DK
authors.lastname: Herrmann
authors.forename: B
authors.initials: B
authors.lastname: Hegenscheid
mesh_terms: D000818:Animals; D008288:Malaria / Q000628:therapy*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects*; D014329:Tropical Climate
chemical_list: D010936:Plant Extracts
vernacular_title: Wirkung eines Extraktes aus Cochlospermum angolense ("Burututu") auf Plasmodium berghei im Mäusemalaria-Suppressionstest.