[Antifungal and fungicidal activities of tea extract and catechin against Trichophyton].
We examined tea extract, (-) epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) for their antifungal and fungicidal activities against Trichophyton mentagrophytes, T. rubrum, Candida albicans and Cryptococcus neoformans. Tea extract (2.5%) inhibited completely the growth of both T. mentagrophytes and T. rubrum. EGCg at 2.5 mg/ml failed to inhibit their growth, whereas TF3 at 0.5 mg/ml inhibited the growth. EGCg (1mg/ml) showed no fungicidal activity against Trichophyton. TF3 (1mg/ml) killed Trichophyton by a long time contact (72-96 hrs). Tea extract showed a fungicidal activity against Trichophyton in a dose- and contact time-dependent manner. It did not inhibit the growth of C. albicans, but at a high concentration, inhibited slightly the growth of C. neoformans. It had no fungicidal activity against C. albicans or C. neoformans.
Okubo
S
S
Department of Bacteriology and Immunology, Showa University School of Medicine, Tokyo.
Toda
M
M
Hara
Y
Y
Shimamura
T
T
D000935:Antifungal Agents; D044946:Biflavonoids; D002392:Catechin / Q000031:analogs & derivatives*; D005419:Flavonoids / Q000494:pharmacology*; D013662:Tea; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D044946:Biflavonoids; D005419:Flavonoids; D013662:Tea; C056068:theaflavin; D002392:Catechin; C057580:gallocatechol