Excitatory sulphur amino acids evoke a Ca2(+)-independent release of [3H]D-ASP and [3H]GABA from primary neuronal cultures by a mechanism which involves reversal of the high affinity transporters for L-glu and GABA, respectively.
Dunlop
J
J
Department of Biochemistry, University of St. Andrew's, Fife, U.K.
Grieve
A
A
Schousboe
A
A
Griffiths
R
R
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology*; D002352:Carrier Proteins; D002478:Cells, Cultured; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D050485:GABA Plasma Membrane Transport Proteins; D007700:Kinetics; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D027361:Organic Anion Transporters; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; D027361:Organic Anion Transporters; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D003545:Cysteine; D002118:Calcium