Somnogenic activity of pseudomurein in rabbits.
Pseudomurein is a major cell wall component of some archaebacteria that chemically differs from but morphologically, functionally, and structurally resembles eubacterial peptidoglycan. Eubacterial cell wall components, e.g., peptidoglycan, induce changes in sleep and body temperature. We now report that intravenous injections of rabbits with a suspension of pseudomurein from Methanobacterium thermoautotrophicum also induce similar central nervous system effects.
Johannsen
L
L
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
Labischinski
H
H
Krueger
J M
JM
D000818:Animals; D019605:Euryarchaeota / Q000472:pathogenicity*; D010457:Peptidoglycan / Q000494:pharmacology*; D011817:Rabbits; D012890:Sleep / Q000187:drug effects*
D010457:Peptidoglycan