title: t(16;21)(p11.2;q22): a recurrent primary rearrangement in ANLL.
abstract: We have identified three patients with acute nonlymphocytic leukemia (ANLL), subtypes M2, M4, and M7, who had a t(16;21)(p11.2;q22) in the affected cells. There are six previously reported cases of ANLL with the same t(16;21). The t(6;21) should therefore be included as another primary rearrangement in ANLL. Follow-up of these cases, though still limited, suggests a poor prognosis, as most patients have achieved a clinical remission but only for a short duration.
authors.affiliation: Cancer Center of Southwest Biomedical Research Institute and Genetrix, Inc., Scottsdale, Arizona 85251.
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: C B
authors.initials: CB
authors.lastname: Riske
authors.forename: A
authors.initials: A
authors.lastname: Meloni
authors.forename: C A
authors.initials: CA
authors.lastname: Ries
authors.forename: C H
authors.initials: CH
authors.lastname: Johnson
authors.forename: R S
authors.initials: RS
authors.lastname: Lemons
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000328:Adult; D002675:Child, Preschool; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic