Protein kinase activity of rat brain hexokinase.
Hexokinase 1 (HK1) purified from rat brain exhibits protein kinase activity, including autophosphorylation and phosphorylation of histone H2A. This protein kinase activity is observed only in the absence of the HK1 carbohydrate substrate, glucose. Analysis of the ATP-binding domains of the mammalian HK1 protein sequences shows significant homology with other mammalian protein kinases.
Adams
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Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Griffin
L D
LD
Gelb
B D
BD
McCabe
E R
ER
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D006593:Hexokinase / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D006657:Histones; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013379:Substrate Specificity
D006657:Histones; D007527:Isoenzymes; D011494:Protein Kinases; D006593:Hexokinase