Use of a pharmacokinetic-dynamic model for the automatic feedback control of atracurium.
A control algorithm for the closed-loop control of atracurium-induced neuromuscular blockade based on pharmacokinetic-dynamic model-based adaptive feedback is described. Mean offset from setpoint at 90% neuromuscular block was 0.04% and the mean standard deviation from mean neuromuscular block was 1.9%. The mean average atracurium requirement was 0.37 mg.kg-1.h-1. The model-based adaptive closed-loop control of atracurium infusion provided reasonable control of muscle relaxation. It offers a solution to the problem of adapting pharmacokinetic and pharmacodynamic data to individuals when using mean data as starting values for drug therapy.
Schwilden
H
H
Institut für Anästhesiologie, Rheinische Friedrich-Wilhelms-Universität, FRG.
Olkkola
K T
KT
D000328:Adult; D000368:Aged; D001279:Atracurium / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001676:Biofeedback, Psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008432:Mathematical Computing; D008722:Methods; D008875:Middle Aged; D008954:Models, Biological; D010599:Pharmacokinetics
D001279:Atracurium