Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Comparable degree of liver cirrhosis, as judged by liver function tests and histopathology, was induced in rats by carbon tetrachloride. Comparative organ distribution of 99mTc-sulphur colloid and 99mTc-phytate was studied in the liver, spleen and lungs of these cirrhotic rats. Compared to controls, the biodistribution of 99mTc-sulphur colloid was found to be affected more than that of 99mTc-phytate in cirrhotic rats, especially at early time intervals.
Nadkarni
G D
GD
Radiation Medicine Centre, Tata Memorial Centre Annexe, Parel, Bombay.
Shimpi
H H
HH
Noronha
O P
OP
D000818:Animals; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D008099:Liver / Q000000981:diagnostic imaging; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010634:Phenobarbital; D010833:Phytic Acid / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013671:Technetium Tc 99m Sulfur Colloid / Q000493:pharmacokinetics*
D015609:Organotechnetium Compounds; C026177:technetium phytate; D013671:Technetium Tc 99m Sulfur Colloid; D010833:Phytic Acid; D002251:Carbon Tetrachloride; D010634:Phenobarbital