High sensitivity of porcine cerebral arteries to endothelin.
The threshold concentration of endothelin to induce contractions in porcine cerebral arteries (anterior cerebral, Willis ring and basilar artery) was lower than those for coronary and renal arteries. The median effective concentrations (ED50) of endothelin in cerebral arteries were also significantly lower than those for coronary and renal arteries. There was no significant difference in the sensitivity to endothelin among cerebral arteries, or between coronary and renal arteries. The maximal percentage of contractions induced by endothelin, as compared to that induced by 10(-1) M potassium chloride, was not significantly different between the arteries.
Fukuda
S
S
Department of Anesthesiology, Niigata University School of Medicine, Japan.
Taga
K
K
Shimoji
K
K
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects; D002536:Cerebral Arteries / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D012077:Renal Artery / Q000187:drug effects; D012680:Sensitivity and Specificity; D013552:Swine
D016232:Endothelins; D011189:Potassium Chloride