title: The effect of H-2 region and genetic background on hormone-induced ovulation rate, puberty, and follicular number in mice.
abstract: We have examined the effects of major histocompatibility (H-2) haplotypes and genetic background (all loci other than the H-2 region) on hormone-induced ovulation rate in congenic strains of mice. In comparison with the H-2a haplotype, the H-2b haplotype increased hormone-induced ovulation rate 92% on the A/J (A) genetic background. However, H-2 haplotype did not affect hormone-induced ovulation rate on the C57BL/10J (C57) genetic background. The H-2b-linked gene(s) increased hormone-induced ovulation rate on the A/J genetic background largely by (1) enhancing the maturation of follicles in response to pregnant mare's serum gonadotrophin (PMSG) and (2) altering the stages of follicular development which can be induced to ovulate in response to human chorionic gonadotrophin (hCG). The observed effects of H-2 on hormone-induced ovulation rate were not explained by differences in the timing of puberty, the number of follicles present in untreated females, or the incidence of follicular atresia. The effect of genetic background on hormone-induced ovulation rate was much greater than was the effect of the H-2 region. We found that hormone-induced ovulation rate was five- to six-fold higher on the C57 genetic background than on the A genetic background. The C57 genetic background increased hormone-induced ovulation rate by (1) enhancing the induction of follicular maturation in response to gonadotropins and (2) by reducing the incidence of follicular atresia.
authors.affiliation: Reproductive Endocrinology Program, University of Michigan, Ann Arbor.
authors.forename: J L
authors.initials: JL
authors.lastname: Spearow
authors.forename: R P
authors.initials: RP
authors.lastname: Erickson
authors.forename: T
authors.initials: T
authors.lastname: Edwards
authors.forename: L
authors.initials: L
authors.lastname: Herbon
mesh_terms: D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D007700:Kinetics; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D006080:Ovarian Follicle / Q000166:cytology; D010060:Ovulation / Q000235:genetics*
chemical_list: D006183:H-2 Antigens