title: The influence of gender on the susceptibility to multiple sclerosis in sibships.
abstract: A population-based study of pairs of relatives (siblings, second- and third-degree) concordant for multiple sclerosis did not show an excess of like-sexed pairs. In addition, data on human lymphocyte antigen typing for sibling pairs concordant for multiple sclerosis did not find an increase in haplotype sharing for like-sexed pairs. These data do not support the notion that sex-related factors influence multiple-sclerosis susceptibility in families.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Sadovnick
authors.forename: D E
authors.initials: DE
authors.lastname: Bulman
authors.forename: L
authors.initials: L
authors.lastname: Hashimoto
authors.forename: M B
authors.initials: MB
authors.lastname: D'Hooghe
authors.forename: G C
authors.initials: GC
authors.lastname: Ebers
mesh_terms: D004198:Disease Susceptibility; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D012723:Sex