Chronic sialadenitis with psammoma bodies mimicking neoplasia in a fine-needle aspiration specimen from the submandibular gland.
A 65-year-old woman with a submandibular gland nodule had a fine-needle aspiration specimen that contained groups of duct-type cells and a psammoma body, suggestive of adenocarcinoma. The resected gland showed chronic sialadenitis with sialolithiasis and psammoma bodies. In a series of 81 resected nonneoplastic submandibular glands from 72 patients, psammoma bodies, nonlaminated microcalcifications, or both were found in 46 (57%). They were located most commonly just outside of striated or intercalated ducts. When examining fine-needle aspiration specimens from the submandibular gland, it is important that one be aware that psammoma bodies may occur in normal, inflamed, irradiated, and neoplastic conditions.
Frierson
H F
HF
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
Fechner
R E
RE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002114:Calcinosis / Q000473:pathology*; D002648:Child; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D012793:Sialadenitis / Q000175:diagnosis / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*