[Different effects of peptides and their amino acids on antibody production and phagocytic activity of the neutrophils in mice].
The effects of some natural polypeptides fragments and amino acids which were incorporated in them on the thymus-dependent SRBC immune response and on the phagocytosis of Staphylococcus by murine peritoneal neutrophils were compared. It was found that the peptides LGIP and PYIK which consisted of those amino acids that stimulated phagocytosis but did influence the immune response (K, P, Y, L) did not change the immune response as well as phagocytosis. The peptides TKPR, TTKD and LGIPE which included those amino acids that were able to stimulate both immune response and phagocytosis (T, E, D) enhanced both activities. Nevertheless the peptide PYIKV containing valine (that stimulated the antibody production as well as phagocytosis) did not effect the immune response but enhanced the phagocytic index. The existence of two immunoregulatory systems--the peptide system and the amino acid one--was suggested.
Belokrylov
G A
GA
Popova
N V
NV
Molchanova
O Ia
OIa
Sorochinskaia
E I
EI
Anokhina
V V
VV
D000276:Adjuvants, Immunologic; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000276:immunology*; D013268:Stimulation, Chemical
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D000907:Antibodies, Bacterial; D010446:Peptide Fragments
Neodnoznachnost' deĭstviia peptidov i sostavliaiushchikh ikh aminokislot na antitelogenez i fagotsitarnuiu aktivnost' neĭtrofilov u mysheĭ.