Cap-binding complex protein p220 is not cleaved during echovirus 22 replication in HeLa cells.
Previously we demonstrated that echovirus 22 is an atypical enterovirus which does not shut off host cell protein synthesis. We extend these findings by showing that echovirus 22 does not cleave p220, part of the cellular cap-binding complex necessary for cap-dependent translation, suggesting a biology more consistent with cardioviruses than enteroviruses.
Coller
B G
BG
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495.
Tracy
S M
SM
Etchison
D
D
D002352:Carrier Proteins / Q000378:metabolism*; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D010849:Picornaviridae / Q000254:growth & development*; D014176:Protein Biosynthesis; D039381:RNA Cap-Binding Proteins; D012315:RNA Caps / Q000378:metabolism; D014779:Virus Replication
D002352:Carrier Proteins; D039381:RNA Cap-Binding Proteins; D012315:RNA Caps