LDL- and agonist-induced Ca(2+)-mobilization in platelets of healthy subjects and in patients with familial hyperlipoproteinemia type II.
LDL induced a reversible increase in [Ca2+]i in platelets of healthy subjects and FH-patients. In both groups the effects of LDL were potentiated 2.3-fold by epinephrine. [Ca2+]i increases, induced by LDL, ADP and PAF were more prominent in platelets of FH-patients. This may explain the platelet hyperaggregability in such conditions.
Bochkov
V N
VN
Cardiology Research Center of the USSR, Moscow.
Rozhkova
T A
TA
Matchin YuG
Lyakishev
A A
AA
Bochkova
N A
NA
Borisova YuL
Kukharchuk
V V
VV
Tkachuk
V A
VA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000503:physiopathology*; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology
D008077:Lipoproteins, LDL; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate; D002118:Calcium; D004837:Epinephrine