title: Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals.
abstract: Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver lesions. Long-term chemical carcinogenesis studies could be easily and feasibly designed using laboratory rodents offered diets containing fish caught in polluted waters. Induced cancers in rodents would corroborate field observations in fish; positive results from these studies would provide further evidence about potential human health hazards from eating substantial amounts of chemically contaminated fish. Nonetheless, fish and aquatic organisms should be viewed as environmental biological monitors of pollution or of potential human health hazards, and authorities responsible for assuring clean and safe rivers, bodies of water, and biota should give more attention to these valid biological indicators or sentinels of environmental pollution. Consequently, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards.
authors.affiliation: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
authors.forename: J
authors.initials: J
authors.lastname: Huff
authors.forename: J
authors.initials: J
authors.lastname: Bucher
authors.forename: R
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D015986:Confounding Factors, Epidemiologic; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D008113:Liver Neoplasms / Q000139:chemically induced; D051379:Mice; D012107:Research Design; D012306:Risk; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D002274:Carcinogens, Environmental; D014874:Water Pollutants, Chemical