Preliminary study on serum levels of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D in cadmium-induced renal tubular dysfunction.
Serum 1,25-dihydroxyvitamin D [1,25(OH)2D] and 25-hydroxyvitamin D [25(OH)D] were measured in 7 women living in a cadmium-polluted area in Toyama, Japan. Despite the fact that these subjects had severe proximal renal tubular dysfunction showing increased fractional excretion of beta 2-microglobulin (FE beta 2-m) ranging from 9.7-49.1% with a mean of 30.7%, the levels of serum 1,25(OH)2D, which is produced in the proximal tubules, were within the normal range in 6 subjects. Significant correlations were found between 1,25(OH)2D and creatinine clearance (r = 0.802, P less than 0.05), and FE beta 2-m (r = -0.829, P less than 0.05), respectively. These results suggest that renal production of 1,25(OH)2D decreases with progression of cadmium-induced renal tubular dysfunction.
Aoshima
K
K
Department of Public Health, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Kasuya
M
M
D015652:25-Hydroxyvitamin D 2 / Q000097:blood*; D000368:Aged; D002104:Cadmium / Q000633:toxicity*; D002117:Calcitriol / Q000097:blood*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D001613:beta 2-Microglobulin / Q000378:metabolism
D010281:Parathyroid Hormone; D001613:beta 2-Microglobulin; D002104:Cadmium; D015652:25-Hydroxyvitamin D 2; D003404:Creatinine; D002117:Calcitriol