title: Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
abstract: Comparable degree of liver cirrhosis, as judged by liver function tests and histopathology, was induced in rats by carbon tetrachloride. Comparative organ distribution of 99mTc-sulphur colloid and 99mTc-phytate was studied in the liver, spleen and lungs of these cirrhotic rats. Compared to controls, the biodistribution of 99mTc-sulphur colloid was found to be affected more than that of 99mTc-phytate in cirrhotic rats, especially at early time intervals.
authors.affiliation: Radiation Medicine Centre, Tata Memorial Centre Annexe, Parel, Bombay.
authors.forename: G D
authors.initials: GD
authors.lastname: Nadkarni
authors.forename: H H
authors.initials: HH
authors.lastname: Shimpi
authors.forename: O P
authors.initials: OP
authors.lastname: Noronha
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D008099:Liver / Q000000981:diagnostic imaging; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010634:Phenobarbital; D010833:Phytic Acid / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013671:Technetium Tc 99m Sulfur Colloid / Q000493:pharmacokinetics*
chemical_list: D015609:Organotechnetium Compounds; C026177:technetium phytate; D013671:Technetium Tc 99m Sulfur Colloid; D010833:Phytic Acid; D002251:Carbon Tetrachloride; D010634:Phenobarbital