The effect of 19-hydroxy prostaglandins on the human myometrium in vitro.
Human semen contains high amounts of different prostaglandins of which the quantitatively dominating compounds are 19-hydroxy PGE and 19-hydroxy PGF. The effect of PGE and PGF on the contractility of the human uterus is well known whereas the corresponding 19-hydroxy derivatives have not previously been examined in detail. In the present investigation 19-hydroxy PGE1 was shown to dose-dependently decrease the frequency and the amplitude of the contractions in human myometrial tissue in vitro. The effect of seminal 19-hydroxy prostaglandins may thus be of importance for sperm transport through the female genital tract.
Gottlieb
C
C
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
Andersson
E
E
Fried
G
G
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009215:Myometrium / Q000187:drug effects*; D012661:Semen / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects
C025128:19-hydroxyprostaglandin E1; C025183:19-hydroxyprostaglandin F; D015237:Dinoprost; D000527:Alprostadil