[Increased serum alpha 1-antitrypsin does not produce a rise in fecal alpha 1-antitrypsin in patients with healthy intestines].
Fecal alpha-1-Antitrypsin (alpha-1-AT) was related to serum alpha-1-AT concentration in 50 healthy controls, 51 patients with extraintestinal inflammatory disease as well as in 23 patients with ulcerative colitis with mild or severe disease activity. alpha-1-AT concentrations were measured by radial immunodiffusion. Even though serum alpha-1-AT concentration was elevated above normal limits in all patients, a concomitant increase of fecal alpha-1-AT was found only in patients with ulcerative colitis. In these patients a positive correlation between fecal alpha-1-AT-clearance and -concentration and severity and extension of inflammation could be demonstrated. It is concluded that elevated blood levels of alpha-1-AT do not cause increases in fecal alpha-1-AT loss and that fecal alpha-1-AT excretion is increased specifically in patients with intestinal inflammation.
Stufler
M H
MH
Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität, Mainz.
Ewe
K
K
Gierlasinski
B
B
Prün
H
H
Zutt
M
M
D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005243:Feces / Q000737:chemistry*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000175:diagnosis; D006801:Humans; D007239:Infections / Q000097:blood / Q000175:diagnosis; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin
Erhöhtes Serum-alpha-1-Antitrypsin verursacht bei darmgesunden Patienten keinen Anstieg des fäkalen alpha-1-Antitrypsin.