title: Homologs of eleven loci on human chromosome 11 assigned to two owl monkey chromosomes.
abstract: We localized 11 loci mapped to human chromosome 11 to two chromosomes, 4 and 19 of owl monkey karyotype VI (2n = 49/50), by the use of somatic cell hybrids. Furthermore, using in situ hybridization to chromosomes of two owl monkey karyotypes, the HSTF1 oncogene locus was precisely localized on homologs 19q (K-VI) and 2q (K-II). Comparative analysis of available gene-mapping data among human, mouse, and owl monkey chromosomes revealed a pattern of evolutionary change in a syntenic group on human chromosome 11. These structural changes could be explained as having derived from a pericentric inversion of human chromosome region 11cen----q13 and a translocation involving human region 11q22----qter during primate evolution.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
authors.forename: N S
authors.initials: NS
authors.lastname: Ma
authors.forename: D S
authors.initials: DS
authors.lastname: Gerhard
authors.forename: S C
authors.initials: SC
authors.lastname: Bock
mesh_terms: D000818:Animals; D001029:Aotus trivirgatus / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization