title: DNA single strand-breaks in lymphocytes after metronidazole therapy.
abstract: DNA single strand-breaks were examined in lymphocytes of patients treated with metronidazole (CAS 443-48-1) for trichomonas vaginalis infection before, on day one, and day seven of treatment. Recommended dosage of metronidazole induces DNA single strand-breaks. Single strand-breaks were repaired after therapy. No irreversible DNA damage remains. The DNA repair mechanisms are genetically determined. Therefore a mutagenic effect of metronidazole must be discussed in patients with DNA repair defects.
authors.affiliation: Department of Physiological Chemistry, University of Mainz, Fed. Rep. of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Reitz
authors.forename: M
authors.initials: M
authors.lastname: Rumpf
authors.forename: R
authors.initials: R
authors.lastname: Knitza
mesh_terms: D000328:Adult; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000188:drug therapy
chemical_list: D008795:Metronidazole