[Antiradiation properties of radioprotectors, immunomodulators and agents affecting tissue metabolism in fractionated irradiation].
A comparative study was made of the protective efficacy of the per os administered cystamine and mexamine as well as of immunomodulators: decaris and thymoptin, and agents influencing tissue metabolism, such as glutamevite and phosphate concentrate, in conditions of fractionated gamma irradiation at a time interval between fractions of 7 to 1 days. In experiments with (CBA X C57B1/6)F1 and (DBA X C57B1/6)F1 hybrid mice it was shown that with a single exposure cystamine and mexamine protected 40-50% of animals. With a three-fold exposure once a week the efficacy of cystamine was as high as 70%. With exposure every other day the radioprotective efficacy of cystamine and mexamine dropped down to 28.3%. With daily exposure, cystamine was ineffective. Decaris and phosphate concentrate had a slight and transient effect amounting to 10-20%.
Vasin
M V
MV
Chernov
Iu N
IuN
Semenova
L A
LA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D045424:Complex Mixtures; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010710:Phosphates / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D045424:Complex Mixtures; D003879:Dermatologic Agents; D010710:Phosphates; D011837:Radiation-Protective Agents; C051709:glutamevit
Protivoluchevye svoĭstva radioprotektorov, immunomoduliatorov i sredstv, vliiaiushchikh na tkanevoĭ obmen, pri fraktsionirovannom obluchenii.