Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy.
Comparison of total mitochondrial DNA sequences of patients with idiopathic (deleted or hypertrophic) cardiomyopathy with those of patients with Parkinson's disease and mitochondrial encephalomyopathies revealed distinct clustering of point mutations among patients. Furthermore, an inverse relation was found between the total number of base-substitution and life span of the patients. Among point mutations found in each patient, sequentially diverged six clusters consisting of 14, 10, 7, 1, 2, and 3 mutations, respectively, were detected. Five sub-clusters consisting of 2, 2, 11, 1, and 1 mutations, respectively, were detected. From each cluster, the patient's unique mutations were diverged with three types of the mutations specific for the disease. The divergence allowed construction of a phylogenetic tree which clearly indicated that patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathies.
Ozawa
T
T
Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan.
Tanaka
M
M
Sugiyama
S
S
Ino
H
H
Ohno
K
K
Hattori
K
K
Ohbayashi
T
T
Ito
T
T
Deguchi
H
H
Kawamura
K
K
D000328:Adult; D001483:Base Sequence; D009202:Cardiomyopathies / Q000235:genetics* / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000302:isolation & purification; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008931:Mitochondria, Muscle / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D009206:Myocardium / Q000737:chemistry; D009690:Nucleic Acid Conformation; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree
D004272:DNA, Mitochondrial