title: [Therapeutic trial with ivermectin in loiasis with medium and high microfilaremia].
abstract: Treatment with ivermectin at the dosage of 200 microgram/kg in 28 Congolese loiasis patients led to an important decrease of the microfilaremia on day 7, with a reduction of about 90% of the initial parasite load. However, no negativation was observed and, moreover, the parasitemia did not change from day 7 to day 14. Tolerance was quite good, but weak to moderate reactions, linked to the lysis of the microfilariae, were observed in one third of the patients with a microfilaremia greater or equal to 2,500/mm3.
authors.affiliation: Laboratoire de Parasitologie et Mycologie, CHU de Brazzaville, Congo.
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: B
authors.initials: B
authors.lastname: Ebikili
authors.forename: A
authors.initials: A
authors.lastname: Mbitsi
authors.forename: N
authors.initials: N
authors.lastname: Copin
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008118:Loiasis / Q000188:drug therapy* / Q000469:parasitology; D008842:Microfilariae / Q000302:isolation & purification
chemical_list: D007559:Ivermectin
vernacular_title: Essai thérapeutique de l'ivermectine au cours de la loase à moyenne et forte microfilarémie.