title: Infantile isolated sulphite oxidase deficiency: report of a case with negative sulphite test and normal sulphate excretion.
abstract: We present the clinical and biochemical data of a patient with infantile isolated sulphite oxidase deficiency with late onset of symptoms. A comparison of the biochemical parameters is made with the neonatal type of this disease and with the data of described patients with the combined defect of sulphite oxidase and xanthine oxidase, due to molybdenum cofactor deficiency. False-negative sulphite dip stick test as a pitfall in the diagnosis of sulphite oxidase deficiency is discussed.
authors.affiliation: Department of Paediatrics, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: van der Klei-van Moorsel
authors.forename: L M
authors.initials: LM
authors.lastname: Smit
authors.forename: M
authors.initials: M
authors.lastname: Brockstedt
authors.forename: C
authors.initials: C
authors.lastname: Jakobs
authors.forename: C
authors.initials: C
authors.lastname: Dorche
authors.forename: M
authors.initials: M
authors.lastname: Duran
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis* / Q000652:urine; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000172:deficiency*; D013431:Sulfates / Q000652:urine*; D013447:Sulfites / Q000652:urine*
chemical_list: D013431:Sulfates; D013447:Sulfites; D050862:Oxidoreductases Acting on Sulfur Group Donors