A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects.
Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the elderly group. There was no evidence of significant accumulation in either age group.
Baksi
A K
AK
St Mary's Hospital, Newport, Isle of Wight.
Edwards
J S
JS
Ahr
G
G
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015737:Nisoldipine / Q000493:pharmacokinetics* / Q000494:pharmacology
D015737:Nisoldipine