title: Effect of rigid gas permeable contact lens wetting solutions on the rabbit corneal epithelium.
abstract: This investigation was designed to compare the effects of three rigid gas permeable (RGP) contact lens solutions on the rabbit corneal epithelium. Boston Advance Conditioning Solution, Boston Conditioning Solution, and Allergan Wet-N-Soak, which are preserved with 0.0015% polyaminopropyl biguanide, 0.006% chlorhexidine gluconate, and 0.003% benzalkonium chloride, respectively, were evaluated by scanning (SEM) and transmission electron microscopy (TEM). Our results show that Boston Advance Conditioning Solution is significantly more toxic to the corneal epithelium than either Boston Conditioning Solution or Allergan Wet-N-Soak Plus. This is presumably due to the presence and concentration of the preservative, 0.0015% polyaminopropyl biguanide. Although this study was conducted using rabbits, the results raise clinical concerns for human RGP contact lens wearers.
authors.affiliation: School of Optometry, Indiana University, Bloomington.
authors.forename: C G
authors.initials: CG
authors.lastname: Begley
authors.forename: P J
authors.initials: PJ
authors.lastname: Waggoner
authors.forename: G S
authors.initials: GS
authors.lastname: Hafner
authors.forename: T
authors.initials: T
authors.lastname: Tokarski
authors.forename: R E
authors.initials: RE
authors.lastname: Meetz
authors.forename: W H
authors.initials: WH
authors.lastname: Wheeler
mesh_terms: D000818:Animals; D001548:Benzalkonium Compounds / Q000633:toxicity; D001645:Biguanides / Q000633:toxicity; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000633:toxicity; D003261:Contact Lenses; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D009883:Ophthalmic Solutions / Q000633:toxicity*; D011310:Preservatives, Pharmaceutical / Q000633:toxicity; D011817:Rabbits; D011897:Random Allocation
chemical_list: D001548:Benzalkonium Compounds; D001645:Biguanides; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; C064420:polyaminopropylbiguanide; C010882:chlorhexidine gluconate; D002710:Chlorhexidine