[Intake of disopyramide led to diagnosis of insulinoma].
A single dose of 250 mg disopyramide provoked severe hypoglycaemia and confusion in a 75-year-old woman. During subsequent investigation, fasting provoked symptomatic hypoglycaemia (venous blood glucose, 1.6 mumol/1) after 23 hours, plasma concentrations of insulin and C peptide then being 19 micrograms/ml and 0.85 pmol/l, respectively; computerised tomography and ultrasonography of the pancreas n.a.d. However, at laparotomy, a 10 mm diameter insulinoma was detected by intra-operative ultrasonography and palpation. The tumour was removed. To our knowledge, this is the first reported case of an insulinoma being detected due to intake of disopyramide.
Alvarsson
M
M
endokrinologiska kliniken, Akademiska sjukhuset, Uppsala.
Grill
V
V
Hamberger
B
B
Grimelius
L
L
D000368:Aged; D004206:Disopyramide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007340:Insulinoma / Q000097:blood / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*
D004206:Disopyramide
Intag av disopyramid ledde till insulinomdiagnos.