Propranolol:methacrylic acid copolymer binding interaction.
The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol.HCl to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.
Lee
H K
HK
Pharmacy Research and Development, Wyeth-Ayerst Research, Rouses Point, NY 12979.
Hajdu
J
J
McGoff
P
P
D000494:Allosteric Regulation; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D003956:Dialysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008956:Models, Chemical; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011433:Propranolol / Q000737:chemistry*; D012995:Solubility
D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D011433:Propranolol