Does the association dipyridamole-aspirin only act by a functional synergism?
1. Some of the antiplatelet effects of the dipyridamole-aspirin association may be explained by a functional (additive) synergism, but other effects by a potentiation synergism. 2. Platelet adhesivity and aggregation induced by ADP, adrenaline and collagen, and malondialdehyde production, are tests in which dipyridamole and aspirin shows a potentiation synergism.
De la Cruz
J P
JP
Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Spain.
Sanchez de la Cuesta
F
F
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000097:blood; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors
D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D008315:Malondialdehyde; D004176:Dipyridamole; D001241:Aspirin