Pinocembrine: a bioactive flavanone from Teloxys graveolens.
Bioactivity directed fractionation of the acetone extract of Teloxys graveolens (Willd.) Weber (Chenopodiaceae), using the brine shrimp lethality test, led to the isolation of 5,7-dihydroxyflavanone (pinocembrine) (LC50 = 4.25 micrograms/ml) as the only active compound. Pinocembrine also exhibited fasciolicide, ovicide and larvicide activities on newly excysted Fasciola hepatica, on infective eggs of Ascaridi galli and on stage three larvae of Stomoxys calcitrans, respectively.
Del Rayo Camacho
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Division de Bioquimica y Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F.
Sanchez
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B
Quiroz
H
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Contreras
J L
JL
Mata
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R
D000818:Animals; D000871:Anthelmintics; D001156:Artemia; D001197:Ascaridia / Q000187:drug effects; D005210:Fasciola hepatica / Q000187:drug effects; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D007313:Insecta; D007306:Insecticides; D007814:Larva / Q000187:drug effects; D008297:Male; D008800:Mexico; D010936:Plant Extracts / Q000032:analysis*; D010946:Plants, Medicinal
D000871:Anthelmintics; D044950:Flavanones; D005419:Flavonoids; D007306:Insecticides; D010936:Plant Extracts; C016063:pinocembrin