Antimicrobial and cytotoxic activity of transition metal chelates with some heterocyclic imines.
Cu(II), Ni(II), Co(II), and Zn(II) chelates with two heterocyclic imines derived from 2-furylglyoxal-2(1)-aminothiophenol (FGATP) and 2-thiophenylglyoxal-anthranilicacid (TGAA) were synthesized. Elemental analysis, molar conductance, magnetic measurements and IR and electronic spectral data were explored to elucidate their probable structures. Different crystal field parameters were also calculated to ascertain the geometry of the resulting chelates. All the ligands and their metal chelates were screened, in vitro, for their antimicrobial activity against two bacteria: S. aureus and E. coli and two fungi, viz: A. niger and C. albicans. The in vitro cytotoxic activity of all the compounds was also assessed.
Sharma
R C
RC
Department of Chemistry, Agra University, India.
Varshney
V K
VK
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002614:Chelating Agents; D008670:Metals; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc