[Structural and functional aspects of erythrocyte membrane in children, delivered with asphyxia].
Serum and red blood cell membrane lipid peroxidation (LPO), antioxidative activity (AOA) of the ceruloplasmin/transferrin (CP/TF) system, and biophysical parameters of the structure of a red blood cell membrane lipid bilayer were examined in fetuses experienced acute hypoxia at birth and in babies born to healthy mothers with uncomplicated pregnancy. The intensity of LPO product accumulation in mild asphyxia was ascertained to be proportional to the duration of hypoxic exposure of a fetus. In severe asphyxia accompanied by lower formation of primary LPO products, the levels of secondary LPO products showed a rise. A slight increase of AOA in the CP/TF system was unable to adequately compensate a high intensity of LPO processes, which provides strong evidence for altered structural parameters in the lipid bilayer. It was concluded that it was essential to correct hypoxic states in children with antioxidants immediately after birth.
Pavlova
T A
TA
Shalina
R I
RI
Kazakova
L E
LE
Egorov
D Iu
DIu
Azizova
O A
OA
D000975:Antioxidants / Q000627:therapeutic use*; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000188:drug therapy; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D005311:Fetal Hypoxia / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D010084:Oxidation-Reduction; D011247:Pregnancy
D000975:Antioxidants
Strukturno-funktsional'nye svoistva éritrotsitarnykh membran u deteĭ, rodivshikhsia v asfiksii.