[The dynamics of the chromatin transcription activity in cerebellar Purkinje cells after systemic circulatory arrest].
Transcriptional activity of the dark and light Purkinje cells' nuclei in cerebellar cortex was studied in rats 1h, 24h, 96h and 7 days post a systemic blood circulation arrest. The study was performed with the help of the histoautoradiographic method of Moore. Some substantial changes in template activity of the Purkinje cells' chromatin were observed in the postresuscitation period. Those began to occur immediately after resuscitation and were of phasic nature. The shifts in transcriptional activity of nucleolar and extranucleolar chromatin appeared to be analogous and of similar dynamics. The changes were more significant in the light neurons than in the dark ones. It has been supposed that the changes revealed might be one of the causes of development of neurologic disorders induced by severe hypoxia.
Avrushchenko
M Sh
MSh
Bul'chuk
O V
OV
Grigor'eva
A V
AV
Marshak
T L
TL
Iarygin
V N
VN
D000818:Animals; D001345:Autoradiography; D002466:Cell Nucleolus / Q000502:physiology; D002843:Chromatin / Q000502:physiology*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D003643:Death; D006323:Heart Arrest / Q000503:physiopathology*; D008297:Male; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D012151:Resuscitation; D013997:Time Factors; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D012321:DNA-Directed RNA Polymerases
Dinamika transkriptsionnoĭ aktivnosti khromatina kletok Purkin'e mozzhechka posle ostanovki sistemnogo krovoobrashcheniia.