Two different microtubule-based motor activities with opposite polarities in kinetochores.
The movement of microtubules on the kinetochores of isolated chromosomes has been examined by video microscopy. Two different microtubule-based motors on the kinetochore were identified, which have opposite directions of movement. The activities of these two motors can be regulated by factors that can influence phosphorylation.
Hyman
A A
AA
Department of Pharmacology, University of California, San Francisco 94143.
Mitchison
T J
TJ
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D008941:Spindle Apparatus / Q000502:physiology*
D000225:Adenine; D000255:Adenosine Triphosphate; C022571:adenosine 5'-O-(3-thiotriphosphate); C000730567:6-methyladenine