title: Multiple giant cell tumors and Paget disease of bone: radiographic and clinical correlations.
abstract: The clinical and radiographic findings of four patients with multicentric giant cell tumor (GCT) of bone and Paget disease were retrospectively reviewed. Three patients underwent magnetic resonance (MR) imaging evaluation; all patients underwent computed tomography (CT). The MR characteristics of the bone component in pagetic GCT appeared to reflect the pagetic phase; a sclerotic pattern was largely represented by hypointense marrow signal intensity on images obtained with both long and short repetition times (TRs) and echo times (TEs). Conversely, a tumor appearing in a mixed pagetic phase demonstrated more heterogeneous signal intensity with all pulse sequences. Extensive soft-tissue components, noted in all cases, showed largely intermediate signal intensity on short TR/TE images and foci of increased signal intensity on longer TR/TE images. In most cases, dramatic reduction in tumor bulk was noted with the use of steroids alone. An awareness of this entity is important because the appearance of lytic lesions with soft-tissue extension in patients with Paget disease does not necessarily imply a grave prognosis. Serial CT or MR imaging is helpful in monitoring the remissions and exacerbations that reflect response to therapy in Paget disease and GCT.
authors.affiliation: Department of Radiology and Nuclear Medicine, Hospital for Special Surgery, Cornell University Medical College, New York, NY 10021.
authors.forename: H G
authors.initials: HG
authors.lastname: Potter
authors.forename: R
authors.initials: R
authors.lastname: Schneider
authors.forename: B
authors.initials: B
authors.lastname: Ghelman
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
authors.forename: J M
authors.initials: JM
authors.lastname: Lane
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000000981:diagnostic imaging*; D010001:Osteitis Deformans / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed