An overview of role of matrix components.
The glomerular filtration barrier consists of complex matrix constituents interposed between the glomerular endothelial and epithelial cells, which constitute the lining of the glomerular capillaries. The matrix components include collagen and noncollagenous molecules such as laminin and proteoglycans. This review describes herein the metabolic consequences of diabetes mellitus to which increased permeability of the filtration barrier may be attributed by altering matrix molecules.
Brown
D M
DM
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Charonis
A S
AS
Furcht
L T
LT
Klein
D J
DJ
Mauer
S M
SM
Steffes
M W
MW
Tsilibary
P E
PE
D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000502:physiology*