title: Relationship of HBsAg subtypes with HBeAg/anti-HBe status and chronic liver disease. Part II: Evaluation of epidemiological factors and suspected risk factors of liver dysfunction.
abstract: In this study, we examined a possibility that epidemiological factors or suspected risk factors of liver dysfunction could account for the different HBeAg/anti-HBe status or the different prevalence of liver dysfunction between the adr and adw carriers. A total of 428 HBsAg carriers were surveyed of their age, sex, racial background, socioeconomic status, place of residence, birthplace, alcohol consumption, smoking habit, and history of blood transfusion as epidemiological factors or suspected risk factors of liver dysfunction. Adjustment for those variables using multivariate analyses did not substantially affect the association of the HBsAg subtypes with either prevalence of liver dysfunction or HBeAg/anti-HBe status. HBsAg subtypes seem to directly affect HBeAg/anti-HBe status and consequently influence development of chronic liver disease.
authors.affiliation: Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shiina
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Kawabe
authors.forename: K
authors.initials: K
authors.lastname: Tagawa
authors.forename: T
authors.initials: T
authors.lastname: Unuma
authors.forename: M
authors.initials: M
authors.lastname: Yoneyama
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kurita
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
mesh_terms: D000328:Adult; D002353:Carrier State / Q000276:immunology / Q000503:physiopathology*; D002908:Chronic Disease; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000145:classification; D006513:Hepatitis B e Antigens / Q000097:blood* / Q000276:immunology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens