title: Successful immunization of infants at 6 months of age with high dose Edmonston-Zagreb measles vaccine. Cite Soleil/JHU Project Team.
abstract: A group of 2097 Haitian infants 6 to 11 months of age were randomized to receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10- to 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions were noted. Edmonston-Zagreb vaccines were more effective than equivalent doses of Schwarz vaccines as measured by the proportion of vaccinated children with measles antibody concentrations greater than or equal to 200 mIU/ml 2 months after vaccination and the persistence of antibody at 18 to 24 months of age. High titer Edmonston-Zagreb vaccine administered at 6 months of age induced antibody concentrations greater than or equal to 200 mIU/ml in 83% of infants by plaque reduction neutralization and 93% of infants by enzyme-linked immunosorbent assay with high rates of antibody persistence at 12 to 24 months of age. The World Health Organization recommends high titer Edmonston-Zagreb measles vaccines for routine use at 6 months of age in areas where measles is an important cause of mortality in young infants.
authors.affiliation: Department of International Health, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
authors.forename: J S
authors.initials: JS
authors.lastname: Job
authors.forename: N A
authors.initials: NA
authors.lastname: Halsey
authors.forename: R
authors.initials: R
authors.lastname: Boulos
authors.forename: E
authors.initials: E
authors.lastname: Holt
authors.forename: D
authors.initials: D
authors.lastname: Farrell
authors.forename: P
authors.initials: P
authors.lastname: Albrecht
authors.forename: J R
authors.initials: JR
authors.lastname: Brutus
authors.forename: M
authors.initials: M
authors.lastname: Adrien
authors.forename: J
authors.initials: J
authors.lastname: Andre
authors.forename: E
authors.initials: E
authors.lastname: Chan
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006205:Haiti; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D014611:Vaccination; D010948:Viral Plaque Assay
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine