Cytotoxic acetylenes from Panax quinquefolium.
Three new cytotoxic polyacetylenes, PQ-1 (1), PQ-2 (2) and PQ-3 (3), have been isolated from Panax quinquefolium. The structures of these acetylenes were determined by analyses of their 1H-1H and 1H-13C COSY spectra. All these compounds exhibited strong cytotoxic activities against leukemia cells (L 1210) in tissue culture.
Fujimoto
Y
Y
College of Pharmacy, Nihon University, Chiba, Japan.
Satoh
M
M
Takeuchi
N
N
Kirisawa
M
M
D000114:Acetylene / Q000031:analogs & derivatives*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D000114:Acetylene