title: Organization of restriction-modification systems.
abstract: The genes for over 100 restriction-modification systems have now been cloned, and approximately one-half have been sequenced. Despite their similar function, they are exceedingly heterogeneous. The heterogeneity is evident at three levels: in the gene arrangements; in the enzyme compositions; and in the protein sequences. This paper summarizes the main features of the R-M systems that have been cloned.
authors.affiliation: New England Biolabs, Inc., Beverly, MA 01915.
authors.forename: G G
authors.initials: GG
authors.lastname: Wilson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D015280:DNA Restriction-Modification Enzymes / Q000235:genetics* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D013379:Substrate Specificity
chemical_list: D015280:DNA Restriction-Modification Enzymes