title: Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human.
abstract: As part of an effort to determine the molecular basis of the prostate-specificity of PSP94, a prostatic secretory protein of 94 amino acids, we have characterized its gene in Rhesus monkey and in human. In both species, the 18 kb gene is organized in four exons and three introns. The sequence of the 0.8 kb promoter region is highly homologous (93.8%) between the two species. A conserved steroid-hormone responsive element was identified in this region, and an estrogen-responsive element in the first intron, suggesting possible regulation of this gene by sex hormones.
authors.affiliation: Laboratoire de Neuroendocrinologie Moléculaire, Université de Montréal, Québec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Nolet
authors.forename: M
authors.initials: M
authors.lastname: Mbikay
authors.forename: M
authors.initials: M
authors.lastname: Chrétien
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005091:Exons; D006801:Humans; D007438:Introns; D008253:Macaca mulatta; D008297:Male; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011467:Prostate; D029584:Prostatic Secretory Proteins; D012333:RNA, Messenger / Q000032:analysis; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D002352:Carrier Proteins; D015342:DNA Probes; D029584:Prostatic Secretory Proteins; D012333:RNA, Messenger; C028321:estramustine-binding protein; D004247:DNA