[Correction of disorders of electric stability of the heart and arrhythmia by using a synthetic analog of acetylcholine].
It was shown in experiments on Wistar male rats that ethyl, 3/2, ethyl, 2/2, dimethylhydrazine propionate iodate (EDIHYP), a synthetic acetylcholine analogue, eliminates in situ the fall of the ventricular fibrillation threshold and the extrasystole observed on the background of vagal bradycardia in experimental myocardial infarction and postinfarction cardiosclerosis. The elimination of disturbed heart electric stability was not accompanied by cholinergic, negative chronotropic effect of the drug. In isolated heart, high concentrations of EDIHYP (10(-4) M) had negative chronotropic effect but lacked antiarrhythmic effect in local ischemia and reperfusion. The bradycardia induced by EDIHYP was absent and the antiarrhythmic effect was strikingly pronounced on the background of muscarinic receptors blockade with atropine. Thus EDIHYP realizes its antiarrhythmic effect not via muscarinic receptors but by some other way which requires studying by methods of molecular pharmacology.
Meerson
F Z
FZ
Kalvin'sh
I Ia
IIa
Abdukaliev
N A
NA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D004127:Dimethylhydrazines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006329:Heart Conduction System / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D011422:Propionates / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D004127:Dimethylhydrazines; D011422:Propionates; C069515:ethyl 3-(2-ethyl-2,2-dimethylhydrazine)propionate
Ustranenie narusheniĭ élektricheskoĭ stabil'nosti serdtsa i aritmii s pomoshch'iu sinteticheskogo analoga atsetilkholina.