title: [Results of trans-sphenoidal surgery for the treatment of acromegaly].
abstract: During the past 17 years (1972-89) 55 transsphenoidal surgery (TSS) interventions were performed in our Hospital in 53 cases of acromagaly (2 cases underwent surgery twice).
  
  
  RESULTS
  22 were cured (40%); 15 partial efficacy (27%) and 18 negative efficacy (33%). Mean GH values (ngr/ml) before surgery were: Cured cases 15.8 + 12.9 (p = 0.0015). Basal GH values above 40 ngr/ml obscure the prognosis of TSS in acromegaly. Cure was perfectly achieved in smaller size hypophysis adenomas (Hardy Grade land 11 in CT scan). The complications in the early post-surgery were rare and transient. Chronic sequelae due to TSS occurred in 7 cases (13.5%), as complete or partial anterior hypophysis failure. TSS is the treatment of choice of acromegaly in our environment, however a significant number of cases do not achieve cure and need to complete treatment with hypophyseal radiotherapy.
authors.affiliation: Servicio de Endocrinología, Hospital Virgen del Rocío, Sevilla.
authors.forename: A
authors.initials: A
authors.lastname: Pumar
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: P P
authors.initials: PP
authors.lastname: García-Luna
authors.forename: D
authors.initials: D
authors.lastname: Acosta
authors.forename: J L
authors.initials: JL
authors.lastname: Pereira
authors.forename: I
authors.initials: I
authors.lastname: Gavilán
authors.forename: A
authors.initials: A
authors.lastname: Leal-Cerro
authors.forename: R
authors.initials: R
authors.lastname: Astorga
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000209:etiology / Q000601:surgery*; D000236:Adenoma / Q000150:complications / Q000601:surgery*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications; D012074:Remission Induction; D013100:Sphenoid Bone
chemical_list: D013006:Growth Hormone
vernacular_title: Resultados de la cirugía transesfenoidal en el tratamiento de la acromegalia.