title: Endothelin-1 inhibits adipogenic differentiation of 3T3-L1 preadipocytes.
abstract: The effect of endothelin (ET)-1 on the adipogenic differentiation of 3T3-L1 preadipocytes was examined. Cellular morphology and lipoprotein lipase activity were used as differentiation markers. ET-1 inhibited the hormone-induced adipogenic differentiation of 3T3-L1 preadipocytes morphologically and biochemically in a dose-dependent manner. These findings promote ET-1 as a potent inhibitor of adipogenic differentiation, playing an important role in cellular differentiation of preadipocytes and making it a significant regulator of lipid metabolism.
authors.affiliation: Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanahashi
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Kusuhara
authors.forename: I
authors.initials: I
authors.lastname: Adachi
authors.forename: O
authors.initials: O
authors.lastname: Abe
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D016232:Endothelins / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D015415:Biomarkers; D016232:Endothelins; D008071:Lipoprotein Lipase; D002118:Calcium