Binding of polonium-210 to liver metallothionein.
The interactions of 210Po at the molecular level in biological systems have received little study even though this alpha-emitting radionuclide occurs widely in nature. Polonium-210 was given subcutaneously to rats and found to be incorporated into liver metallothionein as judged by a number of criteria including heat stability, acetone precipitation, and chromatography. In vitro studies confirmed this binding. The binding of 210Po to metallothionein has implications that may help explain some of the radiation damage 210Po causes intracellularly.
Aposhian
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University Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721.
Bruce
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D000818:Animals; D001667:Binding, Competitive; D002104:Cadmium / Q000378:metabolism; D002853:Chromatography, Liquid; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D011059:Polonium / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D008668:Metallothionein; D011059:Polonium