Increased ALZ-50-reactive neurons in the brains of SIDS infants: an indicator of greater neuronal death?
Brain tissue from 15 infants who had died from sudden infant death syndrome (SIDS) and 15 age-matched control infants was investigated for the presence of degenerating neurons using ALZ-50 immunocytochemical methods. Significantly increased numbers (P less than .0001) of ALZ-50-reactive neurons were found in SIDS infants compared to infants dying of known causes. The location and appearance of such ALZ-50-reactive neurons in SIDS may indicate that the initial degeneration of the central nervous system occurs early in the development of affected infants.
Sparks
D L
DL
Department of Pathology, University of Kentucky Medical Center, Lexington.
Hunsaker
J C
JC
D000911:Antibodies, Monoclonal; D002452:Cell Count; D002470:Cell Survival; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D009474:Neurons / Q000473:pathology*; D013398:Sudden Infant Death / Q000209:etiology / Q000473:pathology*
D000911:Antibodies, Monoclonal