title: Lead given systemically to mice in experimental delay of implantation increases the oxygen consumption of delayed blastocysts.
abstract: The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared with inactive, delayed blastocysts. Inactive, delayed blastocysts from lead-injected mice reached the same level of oxygen consumption even without oestrogen administration. Oestrogen given to the lead-injected mice did not further increase the oxygen consumption of their blastocysts. It is concluded that administration of lead to pre-implantation mice resulted in increased metabolic activity of their blastocysts due either to a direct effect of lead or to an indirect effect, caused by changed composition of the uterine secretion.
authors.affiliation: Department of Human Anatomy, Biomedical Centre, Uppsala, Sweden.
authors.forename: B O
authors.initials: BO
authors.lastname: Nilsson
authors.forename: B
authors.initials: B
authors.lastname: Einarsson
authors.forename: C
authors.initials: C
authors.lastname: Magnusson
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000378:metabolism*; D010065:Embryo Implantation, Delayed / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D010101:Oxygen Consumption / Q000187:drug effects*; D011247:Pregnancy; D014599:Uterus / Q000187:drug effects / Q000502:physiology
chemical_list: D007854:Lead