title: Ocular permeability after systemic administration of endotoxin in humans.
abstract: Acute anterior uveitis in response to the administration of systemic gram-negative endotoxin was studied in humans. The blood-aqueous barrier was evaluated in eight normal human subjects at 8 or 24 hours after systemic administration of purified gram-negative endotoxin. No significant changes in the blood-aqueous barrier were found, as evaluated by permeability to fluorescein, number of aqueous cells, flare, or intraocular pressure, despite profound endotoxin-induced cardiac, pulmonary, and circulatory effects. Gram-negative endotoxin does not appear to affect the human blood-aqueous barrier in doses that can safely be given to humans.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, MN.
authors.forename: D C
authors.initials: DC
authors.lastname: Herman
authors.forename: A F
authors.initials: AF
authors.lastname: Suffredini
authors.forename: J E
authors.initials: JE
authors.lastname: Parrillo
authors.forename: A G
authors.initials: AG
authors.lastname: Palestine
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000166:cytology; D001082:Aqueous Humor / Q000166:cytology / Q000378:metabolism*; D001693:Biological Transport, Active; D002199:Capillary Permeability; D002924:Ciliary Body; D003326:Coronary Circulation / Q000187:drug effects; D004731:Endotoxins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004926:Escherichia coli; D005260:Female; D006339:Heart Rate; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure; D007498:Iris / Q000378:metabolism; D008297:Male
chemical_list: D004731:Endotoxins