[Identification of radiopharmaceutical transport models in functional radionuclide diagnosis].
The paper is devoted to the problems of assessment of structural identification of parameters of compartmental models, employed for processing of the results of radionuclide investigations of function of various physiological systems. Methods for assessment of structural identifiability and a regularized algorithm for the identification of parameters of linear and nonlinear compartmental models of almost any structure were proposed. The algorithm possesses a high rate of convergence of the iteration searching process and a low sensitivity to errors of measurements. It was implemented as a software package in Pascal language and utilized on a RDR 11/34 computer for processing the results of radionuclide diagnosis (using 99mTc-COREN) of function of the reticuloendothelial system.
Bondareva
I B
IB
Narkevich
B Ia
BIa
D000465:Algorithms; D001692:Biological Transport; D003198:Computer Simulation; D006801:Humans; D008433:Mathematics; D008905:Minicomputers; D008954:Models, Biological; D011381:Programming Languages; D011868:Radioisotopes / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging
D011868:Radioisotopes
Identifikatsiia modeleĭ transporta RFP v funktsional'noĭ radionuklidnoĭ diagnostike.