title: Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells.
abstract: Transients of Na+/K+ pump and of Na+/Ca2+ exchange current occur during whole-cell recording from cardiac cells upon quick changes of active Na+ efflux. The transients reflect a temporary loss of control of the subsarcolemmal Na+ concentration. Even in the steady state the control is not complete is certain cells. Quantitative studies on ion transport by whole-cell recording are meaningful only if an adequate control of the submembranal ionic composition is demonstrated.
authors.affiliation: Interdisciplinary Research Centre, Catholic University of Leuven, Kortrijk, Belgium.
authors.forename: F V
authors.initials: FV
authors.lastname: Bielen
authors.forename: H G
authors.initials: HG
authors.lastname: Glitsch
authors.forename: F
authors.initials: F
authors.lastname: Verdonck
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D004553:Electric Conductivity; D006352:Heart Ventricles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011689:Purkinje Cells / Q000378:metabolism; D011817:Rabbits; D012508:Sarcolemma / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium; D011188:Potassium; D002118:Calcium