Repair of DNA damage induced by reactive oxygen species.
DNA repair limits the mutagenic, and thereby the carcinogenic, effect of DNA modifications. Free radicals, particularly reactive oxygen species, induce all forms of DNA damage, including base modifications, base free sites, strand breakage, and cross-links. These lesions are repaired by a variety of enzymes of partly overlapping substrate specificity, some of which may be induced.
Breimer
L H
LH
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital School of Medicine, London, UK.
D001816:Bloom Syndrome / Q000209:etiology / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D005609:Free Radicals; D006801:Humans; D010100:Oxygen
D005609:Free Radicals; D004247:DNA; D010100:Oxygen