[Evaluation of the quality of radiopharmaceutics].
The authors considered the interrelationship of clinical requirements and analytical indicators of quality for a group of pharmaceuticals: radionuclide purity (by the criteria of dose load and the quality of visualization); radiochemical purity (interrelationship with a necessary level of accumulation in investigated organs); chemical admixtures (by the criteria of safety and influence on the diagnostic quality; clinical criteria of quality were under discussion); a coefficient of differential accumulation in the system: organ under study-adjacent tissues; specificity; indices of pharmacokinetics, etc. Correct and all-round evaluation of RP quality on the basis of the above criteria determines, to a great extent, a choice of a labeled compound to be used in a specific radionuclide diagnostic method.
Korsunskiĭ
V N
VN
Tarasov
N F
NF
Kodina
G E
GE
Malinin
A B
AB
D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis; D005069:Evaluation Studies as Topic; D011868:Radioisotopes / Q000032:analysis / Q000493:pharmacokinetics / Q000592:standards*; D012449:Safety; D014018:Tissue Distribution
D011868:Radioisotopes
Otsenka kachestva radiofarmatsevticheskikh preparatov.