Weekly low-dose methotrexate therapy for cutaneous sarcoidosis.
Three patients with severe, treatment-resistant cutaneous sarcoidosis were treated with low-dose oral methotrexate on a weekly basis. Facial granulomas and ulcerations responded best. A response was apparent after several weeks of treatment, but 6 to 9 months were required to reach maximal effect.
Webster
G F
GF
Department of Dermatology, Thomas Jefferson Medical College, Philadelphia, PA 19107.
Razsi
L K
LK
Sanchez
M
M
Shupack
J L
JL
D000284:Administration, Oral; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D012507:Sarcoidosis / Q000188:drug therapy* / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D014456:Ulcer / Q000188:drug therapy
D008727:Methotrexate