Neurotoxic kinins from wasp and ant venoms.
Kinins are polypeptides of 9-18 amino-acid residues containing a bradykinin-like sequence, in some cases as part of a molecule. The bradykinin-like sequence is either bradykinin, Hyp3-bradykinin or Thr6-bradykinin. Kinins are neurotoxic components of wasp and ant venoms, causing in the insect CNS a presynaptic block of the cholinergic transmission by means of an irreversible depletion, probably caused by a non-competitive inhibition of choline uptake.
Piek
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Department of Pharmacology, University of Amsterdam, The Netherlands.
D000595:Amino Acid Sequence; D000818:Animals; D000862:Ant Venoms / Q000737:chemistry*; D001920:Bradykinin / Q000737:chemistry; D007705:Kinins / Q000737:chemistry / Q000633:toxicity*; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009498:Neurotoxins / Q000737:chemistry*; D013569:Synapses / Q000187:drug effects; D014862:Wasp Venoms / Q000737:chemistry*
D000862:Ant Venoms; D007705:Kinins; D009498:Neurotoxins; D014862:Wasp Venoms; D001920:Bradykinin