Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.
The effect of d- and l-enantiomers of propranolol on desipramine-induced anti-immobility effects and on brain desipramine levels was studied in the rat. Intraperitoneal propranolol and desipramine were administered three times, 25, 6, 2 and 24, 5, 1 h respectively, before the test. It was found that l-propranolol but not d-propranolol, at the same doses (2.5 and 5 mg/kg), antagonized 20 mg/kg desipramine without altering desipramine brain levels. It is suggested that blockade of beta-adrenergic receptors rather than membrane-stabilizing or pharmacokinetic effects is responsible for the antagonism of propranolol toward desipramine.
Mancinelli
A
A
Menarini Ricerche Sud, Roma, Italy.
D'Aranno
V
V
Stasi
M A
MA
Lecci
A
A
Borsini
F
F
Meli
A
A
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism / Q000494:pharmacology*; D007099:Imipramine / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013550:Swimming
C036691:didesipramine; D011433:Propranolol; D007099:Imipramine; D003891:Desipramine