title: [Tolerance of ibuprofen. Controlled drug monitoring for the detection of rare side effects].
abstract: In an observational study, 6,299 patients suffering from arthrosis and other rheumatic diseases were treated by 1,258 physicians with coated tablets containing 400 mg or 600 mg ibuprofen (Ibuprofen Klinge 400/600) with a view to establish tolerance and the incidence of rare side effects. The data of a random sample of 500 patients revealed, depending upon the nature of the disease presenting, good to very good improvement of pain, swelling and impaired mobility. Only 3% of the patients reported side effects, 0.3% of which were allergic in nature. Only 0.8% of the patients terminated treatment. The care-providing physicians assessed the results as very good or good in 93.3% for efficacy, and 96.8% for tolerance.
authors.affiliation: Klinge Pharma GmbH, München.
authors.forename: P W
authors.initials: PW
authors.lastname: Billigmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D026741:Physical Therapy Modalities; D011358:Product Surveillance, Postmarketing
chemical_list: D007052:Ibuprofen
vernacular_title: Verträglichkeit von Ibuprofen. Kontrollierte Arzneimittelbeobachtung zur Erfassung seltener Nebenwirkungen.