Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats.
The effects of lithocholic acid (LCA) on late prenatal and early postnatal development were studied. LCA was given in the diet (0.8% by weight) or administered in the drinking water (0.8%) throughout the entire period of pregnancy. The addition of LCA to the drinking water caused a significant reduction in the weight of 20-day-old fetuses as well as their placentas and livers. Feeding LCA to pregnant rats affected postnatal growth of the offspring: their weight was significantly lower than control values until 6 weeks of age. The pattern of postnatal growth was similar in the experimental and control rats. The retardation in growth and development of the offspring was accompanied by microscopic and biochemical changes in their livers.
Zimber
A
A
Department of Animal Science, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
Zusman
I
I
Bentor
R
R
Pinus
H
H
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002779:Cholestasis / Q000150:complications; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006128:Growth / Q000187:drug effects*; D008095:Lithocholic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000002:abnormalities / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D008095:Lithocholic Acid; D000469:Alkaline Phosphatase