Sister-chromatid exchanges induced by 1.3-butadiene and its epoxides in CHO cells.
Sister-chromatid exchanges (SCEs) were analyzed in CHO cells after pulse treatment with 1,3-butadiene, 3,4-epoxy-1-butene (monoepoxybutene) and 1,2:3,4-diepoxybutane (diepoxybutane). A weak dose effect was observed after exposure to 1,3-butadiene but only in the presence of S9 mix. Monoepoxybutene and diepoxybutane were highly effective in inducing SCEs at concentrations of 0.1-1 microM both in the presence and in the absence of S9 mix. At higher concentrations the response was more pronounced without S9 mix.
Sasiadek
M
M
Institute of Occupational Health, Helsinki, Finland.
Järventaus
H
H
Sorsa
M
M
D000818:Animals; D002070:Butadienes / Q000633:toxicity*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004852:Epoxy Compounds / Q000633:toxicity*; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002070:Butadienes; D004852:Epoxy Compounds; D009153:Mutagens; C024370:3,4-epoxy-1-butene; C007366:diepoxybutane; C031763:1,3-butadiene