title: [The effect of Echinacea angustifolia on non-specific cellular immunity in the mouse].
abstract: Echinacea belongs to the most usable plants in medical treatment since many years. It is applicable in the fields of homoepathy and allopathy, however, there are many different ways of treatment. Two species are listed in the European Pharmacopoea: Echinacea angustifolia and Echinacea purpurea. They differ in morphology and their chemical composition. There have been chemical and biological analyses of Echinacea for about 80 years. After exact investigations of these reports, the following result were found: Most chemical analyses were done with Echinacea angustifolia, especially the older ones, whereas biological activity was tested with Echinacea purpurea. In almost all of these experiments, proprietaries were preferred to use in contrast to any plant extracts. Most of the reports, which declared the stimulating biological activity of Echinacea could not resist any critical opinion. So the frequency of medical application of this drug is mainly due to delivered practical knowledge. The experiments described in this study were practised with a water-soluble plant extract of Echinacea angustifolia. Echinacosid one of its low-molecular compounds and proprietaries which contains this plant. Their influence on the unspecified cellular immunity of the mouse after intraperitoneal, intravenous or peroral application was investigated. Under various conditions no effects on the immuno system could be found using the carbon clearance test.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Fakultät für klinische Medizin Mannheim, Universität Heidelberg.
authors.forename: A
authors.initials: A
authors.lastname: Schumacher
authors.forename: K D
authors.initials: KD
authors.lastname: Friedberg
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D004731:Endotoxins; D010936:Plant Extracts
vernacular_title: Untersuchungen zur Wirkung von Echinacea angustifolia auf die unspezifische zelluläre Immunantwort der Maus.