A model of the mechanism of cooperativity and associativity of long-term potentiation in the hippocampus: a fundamental mechanism of associative memory and learning.
Long-Term Potentiation (LTP) has three properties: (1) input specificity, (2) cooperativity and (3) associativity. In a previous paper, we proposed an integrated model of the mechanisms of the induction and maintenance of LTP with input specificity. In this paper, a model of the mechanism of cooperative and associative LTP is described. According to computer simulations of the model, its mechanism is based on the spread of synaptic potentials.
Kitajima
T
T
Faculty of Engineering, Yamagata University, Japan.
Hara
K
K
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003198:Computer Simulation; D003491:Cybernetics; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008960:Models, Psychological; D013569:Synapses / Q000502:physiology