Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs.
Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observed which continued past the 250 min-mark. High garlic doses (15 and 20 mg/kg) provoked bradycardia and T-wave inversion during the first 10-15 min of the experiment with recordings returning to normal and staying normal throughout the remainder of the experiment.
Pantoja
C V
CV
Department of Physiology, Faculty of Biological and Natural Sciences, Universidad de Concepción, Chile.
Chiang
L C
LC
Norris
B C
BC
Concha
J B
JB
D000758:Anesthesia; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D005737:Garlic; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010946:Plants, Medicinal
D000959:Antihypertensive Agents; D004232:Diuretics