[Transferability of cefpirome to cerebrospinal fluid of rabbits with meningitis caused by Staphylococcus aureus].
The transferability of cefpirome (HR810, CPR) to cerebrospinal fluid (CSF) was studied employing rabbits with experimental meningitis caused by Staphylococcus aureus. The mean serum concentration was 362 +/- 6.63 micrograms/ml at 15 minutes after intravenous administration of the drug at a dose level of 100 mg/kg. The mean concentration in CSF was maximum at 60 minutes after administration, and the mean maximum concentration was 14.6 +/- 2.85 micrograms/ml. Pharmacokinetic parameters calculated from these values were as follows, Cmax (CSF/serum): 4.04%; AUC (CSF/serum): 5.14% between 15 and 60 minutes, 8.12% between 15 and 120 minutes and 10.4% between 15 and 180 minutes; T 1/2 for CPR in CSF: 154 minutes; T 1/2 (CSF/serum): 3.96. In comparison to those of other beta-lactam antibiotics which were obtained in the same way, the transferability of CPR was intermediate, but the peak CSF level was high, and in consideration of the antimicrobial potency against the main pathogens of meningitis, it appears worthwhile of running clinical trials for this drug.
Haruta
T
T
Department of Pediatrics, Kobe City General Hospital.
Okura
K
K
Kuroki
S
S
Kobayashi
Y
Y
D000818:Animals; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000382:microbiology; D011817:Rabbits; D013203:Staphylococcal Infections; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome