[Biological indicators of bacterial infection in newborn infants].
Biological markers of neonatal bacterial infection are useful if they bring early indications and if they are sensitive and specific. There are two kinds of tests: hematological signs and acute phase proteins. The most specific hematological signs are, in chronological order: leuconeutropenia--myelemia--neutrophilic polynucleosis. Gestational and post-natal ages have to be taken in consideration for correct interpretation of white cell count and differential. Several acute phase proteins increase in infected newborns: fibrinogen, C reactive protein, orosomucoïd. If determined quantitatively, C reactive protein is a sensitive, specific and early marker allowing, in addition, to follow the reaction to treatment: the return to normal range of CRP and later of orosomucoïd attest for recovery. These biological tests have to be sequentially determined during the first days in order to obtain a maximal information.
Messer
J
J
hôpital de Hautepierre, CHU de Strasbourg.
Donato
L
L
Casanova
R
R
Willard
D
D
D000375:Aging / Q000097:blood / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D015415:Biomarkers / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood
D015415:Biomarkers
Les indicateurs biologiques d'infection bactérienne chez le nouveau-né.