Influence of the injection site on the tumorigenicity of a cloned colon tumor cell line in the rat.
The cloned DHD/K12/TSb line obtained from a chemically-induced rat colon carcinoma, presents tumors which always regress when injected subcutaneously to the syngeneic animal. This study reports that an intraperitoneal injection of the DHD/K12/TSb cells induces a progressive carcinomatosis in a high proportion of the syngeneic rats. This result underlines the effect that the local environment has on tumorigenicity.
Reisser
D
D
Groupe de recherche sur les cancers digestifs, Inserm U252, Faculté de médecine, Dijon, France.
Fady
C
C
Lagadec
P
P
Martin
F
F
D000818:Animals; D002461:Cell Line, Transformed / Q000187:drug effects; D002999:Clone Cells; D003110:Colonic Neoplasms / Q000473:pathology*; D004333:Drug Administration Routes; D005260:Female; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D009857:Oncogenes; D051381:Rats; D011919:Rats, Inbred Strains