title: [Value of systematic preventive antibiotherapy in cardiac pacemaker implantation].
abstract: The aim of this study was to assess the usefulness of prophylactic antibiotics during insertion of a cardiac pacemaker, in order to avoid infection of exteriorisation of infectious origin. The study involved two groups. One hundred and eight patients made up group I, a control group without the use of prophylactic antibiotics. Group II consisted of 101 patients who were given an intravenous injection of 1 or 2 g of oxacillin before surgery, followed up by four days of oral oxacillin (3 g per day). Serum oxacillin levels at the end of the procedure were 0.37 +/- 0.09 mcg/ml, falling within the range of minimum inhibitory concentrations of methicillin-sensitive staphylococci. In the patients of the control group, followed up for 1 to 36 months (mean 12 +/- 11 months), during the first 2 months there were 2 infections, 4 exteriorisations and one cutaneous erosion over the pacemaker. In addition, one exteriorisation and one infection occurred at 17 and 29 months respectively. In patients with exteriorisation of their pacemaker device, there was nothing to suggest an infection and bacteriological specimens were sterile. No obvious infections nor any cutaneous complications occurred in the patients of group II, with prophylactic antibiotics, followed up for 1 to 21 months (mean 6 +/- 5 months). In conclusion, anti-staphylococcal antibiotic treatment appears not only to be capable of avoiding cardiac pacemaker infections but also of preventing exteriorisation of the pacemaker device, which may be linked to hidden infections. A randomised study is nevertheless necessary to confirm this hypothesis.
authors.affiliation: Service de Cardiologie, Centre Hospitalier d'Angoulême, Saint-Michel.
authors.forename: P
authors.initials: P
authors.lastname: Bru
authors.forename: R
authors.initials: R
authors.lastname: Cointe
authors.forename: M
authors.initials: M
authors.lastname: Metge
authors.forename: M N
authors.initials: MN
authors.lastname: Mallet
authors.forename: C
authors.initials: C
authors.lastname: Moyal
authors.forename: E
authors.initials: E
authors.lastname: Dolla
authors.forename: F
authors.initials: F
authors.lastname: Collet
authors.forename: R
authors.initials: R
authors.lastname: Gérard
authors.forename: S
authors.initials: S
authors.lastname: Lévy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011292:Premedication; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Intérêt de l'antibiothérapie prophylactique systématique lors de l'implantation d'un stimulateur cardiaque.