Kinetics of D-xylose absorption in patients with human immunodeficiency virus enteropathy.
D-Xylose absorption was studied in 12 patients with acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex who had had diarrhea for more than 8 weeks, averaged an 11% (range, 3% to 21%) body weight loss during the previous 6 months, and had had negative stool examinations for enteric pathogens. Patients were evaluated by duodenal aspiration and biopsy and received both 25 gm oral and 10 gm intravenous doses of D-xylose. Kinetic analysis of D-xylose absorption was characterized by an absorption rate constant (ka) and a rate constant (ko) reflecting nonabsorptive loss. Extent of D-xylose absorption averaged 18.4% +/- 9.3% (+/- SD) in the 12 patients (normal greater than 60%). Percentage of weight loss during the previous 6 months was negatively correlated with ka (r = -0.69; p = 0.018) in the 11 patients in whom this parameter was reduced but was not correlated with either ko or extent of D-xylose absorption. In these patients with human immunodeficiency virus enteropathy, ka was reduced out of proportion to the minor histologic changes present in the duodenal biopsy specimens.
Ehrenpreis
E D
ED
Department of Medicine, Northwestern University Medical School, Chicago, IL.
Gulino
S P
SP
Patterson
B K
BK
Craig
R M
RM
Yokoo
H
H
Atkinson
A J
AJ
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000378:metabolism*; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D001706:Biopsy; D001835:Body Weight / Q000502:physiology; D003967:Diarrhea / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000209:etiology / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000502:physiology; D008875:Middle Aged; D010950:Plasma Cells / Q000502:physiology; D014994:Xylose / Q000493:pharmacokinetics*
D014994:Xylose