title: A case of virus associated hemophagocytic syndrome and malignant histiocytosis: sometimes a difficult distinction.
abstract: The differential diagnosis among hemophagocytic syndromes and particularly between the virus-associated hemophagocytic syndrome (VAHS) and the malignant histiocytosis (HM) is quite easy in typical cases. Difficulties of interpretation may sometimes ensue when viral-bacteriologic work-ups indicative of VAHS are negative and/or morphologic histiocytic aberrations indicative of HM are missing. The authors present a case of hemophagocytic syndrome with the latter characteristics and discuss the differential diagnosis.
authors.affiliation: Divisione di Medicina generale, ULSS n. 5, Bassano del Grappa.
authors.forename: S
authors.initials: S
authors.lastname: Vespignani
authors.forename: G
authors.initials: G
authors.lastname: Sardeo
authors.forename: S
authors.initials: S
authors.lastname: Castronovo
authors.forename: A
authors.initials: A
authors.lastname: Galassi
authors.forename: E
authors.initials: E
authors.lastname: Venza
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D054747:Histiocytic Sarcoma / Q000175:diagnosis* / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D013154:Spleen / Q000473:pathology