title: [Physiopathologic and clinical implications of protein C deficiencies].
abstract: The protein C system--a complex physiological coagulation inhibition system--is a major regulator which controls thrombin production. Nowadays, its exploration is indispensable for the detection of constitutional or acquired protein C deficiency, side by side with a search for antithrombin III deficiency. This approach, based on the frequent association of recurrent thrombosis, mainly venous, in young subjects with congenital deficiencies, makes it possible to initiate, beside a family survey, an individual and efficient prophylaxis of recurrent thrombosis.
authors.affiliation: Centre de Cardiologie, Hôpital du Bocage, Dijon.
authors.forename: C
authors.initials: C
authors.lastname: Corda
authors.forename: P
authors.initials: P
authors.lastname: Bielefeld
authors.forename: P
authors.initials: P
authors.lastname: Morelon
authors.forename: J F
authors.initials: JF
authors.lastname: Besancenot
authors.forename: J L
authors.initials: JL
authors.lastname: Lorenzini
authors.forename: P
authors.initials: P
authors.lastname: Louis
mesh_terms: D000328:Adult; D020152:Antithrombin III Deficiency; D001777:Blood Coagulation / Q000502:physiology; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency; D012008:Recurrence; D013927:Thrombosis / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D011486:Protein C; D014812:Vitamin K
vernacular_title: Implications physiopathologiques et cliniques des déficits en protéine C.