Continuous monitoring of urea in blood during dialysis.
Urease was immobilized to porous glass and used in combination with a conductivity meter for determining urea in standard solutions as well as in blood from a patient undergoing dialysis. The sampling unit involves a possibility for heparinization at the sampling point and a dialysis step prior to exposure to the enzyme column. The unit operates in a linear mode in the concentration range 5-50 mM. Monitoring of dialysis process gave good correlation with off-line analyses.
Thavarungkul
P
P
Department of Biotechnology, University of Lund, Sweden.
Håkanson
H
H
Holst
O
O
Mattiasson
B
B
D015374:Biosensing Techniques; D004582:Electronics, Medical; D005069:Evaluation Studies as Topic; D015312:Hemodialysis Solutions; D006801:Humans; D008991:Monitoring, Physiologic; D006435:Renal Dialysis; D014508:Urea / Q000097:blood*; D014510:Urease
D015312:Hemodialysis Solutions; D014508:Urea; D014510:Urease