[Cell-membrane aspects of the pathogenesis of hypoxia in vibration disease induced by local vibration].
A study was made of the blood and tissue oxygen regime in patients with vibratory disease (VD) induced by local vibration and of the importance of lipid peroxidation (LPO) in oxygenation disorders. Venous hyperoxia, a decrease of the arteriovenous difference according to oxygen, the percentage of oxygen utilization by tissues, shift of the acid-base balance towards metabolic acidosis were established, attesting to tissue hypoxia that increased with the gravity of VD. The importance of a steady activation of LPO and depression of the antioxidant system in the pathogenesis of hypoxia associated with VD was supported by the correlation analysis data on oxygen balance and LPO, the functional and metabolic characteristics of red blood cells (according to the viscosity of red blood cell suspension and the content in the cells of SH-groups, lipoproteins and histidine) and platelets (according to aggregation in response to ADP and thrombin) as well as by the level of blood serum fluorescence. The authors provide evidence for the use of antioxidants (a complex of alpha-tocopherol with ascorbic acid and methionine and calcium antagonists of the nifedipine group), giving a membranostabilizing effect, in multimodality treatment of patients afflicted with VD.
Sukharevskaia
T M
TM
Loseva
M I
MI
Bolotnova
T V
TV
Shpagina
L A
LA
Pakhomova
A M
AM
D000137:Acid-Base Imbalance / Q000503:physiopathology; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use; D001809:Blood Viscosity / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D014732:Vibration / Q000009:adverse effects*
D000975:Antioxidants; D010100:Oxygen
Kletochno-membrannye aspekty patogeneza gipoksii pri vibratsionnoĭ bolezni ot vozdeĭstviia lokal'noĭ vibratsii.