[Experimental substantiation of MPEL of 3-phenoxybenzyl chloride in water reservoirs].
On the basis of experimental studies it was established, that the threshold concentration of 3-phenoxybenzyl chloride (PBC) according to the influence on organoleptic water properties (odour) is 0.03 mg/l, on the sanitary regimen of water reservoirs (BOD inhibition)--0.3 mg/l. The chemical produces low toxicity when administered parenterally, it is highly toxic when administered subcutaneously; cumulation degree is medium. PBC produces a weak allergic effect, an expressed embryotoxic effect; mutagenic activity was not detected. The maximal no-effect dose according to the embryotoxic effect is 0.12 mg/kg (2.4 mg/l), the calculated maximal no-effect concentration is 0.11-0.34 mg/l when administered subcutaneously. The recommended MAC is 0.03 mg/l according to the organoleptic index of harmfulness (odour) with a note 'dangerous when administered through skin' (the third class of danger).
Shtabskiĭ
B M
BM
Fedorenko
V I
VI
Siarchinskiĭ
I I
II
Avgustinovich
M S
MS
Khoma
O A
OA
Tomkiv
V M
VM
D000818:Animals; D001593:Benzyl Compounds / Q000627:therapeutic use; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D008452:Maximum Allowable Concentration; D009152:Mutagenicity Tests; D009812:Odorants; D011247:Pregnancy; D051381:Rats; D014881:Water Supply / Q000032:analysis / Q000592:standards*
D001593:Benzyl Compounds; C069551:3-phenoxybenzyl chloride
Eksperimental'noe obosnovanie PDK 3-fenoksibenzilklhlorida v vode vodoemov.