Effect of carrageenan on humoral and protective immune responses of chicks vaccinated with Newcastle disease virus.
The effect of carrageenan (CGN) treatment on the generation of humoral and protective immune response to Newcastle disease virus vaccine was investigated in chicks. Carrageenan treatment significantly impaired the primary humoral immune response in vaccinated chicks. Further, the protective immune response in CGN-treated chicks was only 50% of that in the control vaccinated chicks. However, the post-challenge response was not altered by drug treatment. Indomethacin, a potent inhibitor of prostaglandin synthesis, was able to reverse the immunosuppressive effect of CGN. This finding suggests that prostaglandins might be involved in CGN-mediated immunosuppression in chicks.
Nachimuthu
K
K
Department of Microbiology, Madras Veterinary College, India.
Masillamony
P R
PR
Padmanaban
V D
VD
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000914:Antibodies, Viral / Q000096:biosynthesis; D002351:Carrageenan / Q000494:pharmacology*; D002645:Chickens; D007108:Immune Tolerance / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage; D009521:Newcastle Disease / Q000276:immunology* / Q000517:prevention & control; D009522:Newcastle disease virus / Q000276:immunology*; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000914:Antibodies, Viral; D002351:Carrageenan; D007213:Indomethacin