title: Intraperitoneal chemotherapy: analysis of complications with an implanted subcutaneous port and catheter system.
abstract: To determine the morbidity associated with delivery of intraperitoneal chemotherapy via subcutaneous semipermanent infusion catheters, we analyzed the data on 227 patients treated from April 1985 through December 1989. A total of 249 catheters were inserted and used to administer chemotherapy in these patients. There were 40 (17.6%) complications associated with the use of 230 original catheters, with 20 patients experiencing catheter inflow obstruction and 20 developing catheter-related infections; the latter group included 8 patients with bowel perforations. Although there was a trend toward an increase in catheter-related infections in association with large bowel surgery and appendectomies, sample size limited statistical analysis. There were 7 (36.8%) complications associated with the use of 19 replacement catheters. This rate was significantly increased (P = 0.03) when compared with the complication rate of original catheters. This system functions well and has an acceptable level of morbidity for delivery of intraperitoneal chemotherapy in gynecologic cancer patients.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: S A
authors.initials: SA
authors.lastname: Davidson
authors.forename: S C
authors.initials: SC
authors.lastname: Rubin
authors.forename: M
authors.initials: M
authors.lastname: Markman
authors.forename: W B
authors.initials: WB
authors.lastname: Jones
authors.forename: T B
authors.initials: TB
authors.lastname: Hakes
authors.forename: B
authors.initials: B
authors.lastname: Reichman
authors.forename: L
authors.initials: L
authors.lastname: Almadrones
authors.forename: D
authors.initials: D
authors.lastname: Chapman
authors.forename: J L
authors.initials: JL
authors.lastname: Lewis
authors.forename: W J
authors.initials: WJ
authors.lastname: Hoskins
mesh_terms: D002404:Catheterization / Q000009:adverse effects*; D002408:Catheters, Indwelling; D004868:Equipment Failure; D006801:Humans; D007239:Infections / Q000209:etiology; D007274:Injections, Intraperitoneal; D007422:Intestines / Q000293:injuries; D012189:Retrospective Studies; D014950:Wounds, Penetrating / Q000209:etiology