title: The serological responses of chickens to mass vaccination with a live V4 Newcastle disease virus vaccine in the field and in the laboratory. 2. Layer pullets.
abstract: Layer chickens on a commercial started pullet farm were vaccinated once at 31 to 52 days of age by drinking water or aerosol with live V4 Newcastle disease virus (NDV) vaccine. Flockmates which had been rehoused in laboratory isolation pens shortly beforehand were similarly vaccinated. Samples of birds were bled at intervals and the serums tested for haemagglutination inhibiting antibody to NDV. Log2 mean titres of up to 4.88 and assumed protection levels (based on the percentage of birds with log2 titres of 4 or greater) of up to 81%, were obtained in the field trials within 4 weeks of vaccination. A subsequent laboratory trial further compared the response of different breeds of chicken to different routes of vaccination. Differences were observed between breeds, routes of vaccination, and parallel field and laboratory trials. The results show that this V4 vaccine can produce an adequate serological response following mass vaccination of Australian layer pullets housed under commercial conditions, and that care should be exercised in extrapolating results obtained under laboratory conditions.
authors.affiliation: New South Wales Department of Agriculture and Fisheries, Elizabeth Macarthur Agricultural Institute, Menangle.
authors.forename: I G
authors.initials: IG
authors.lastname: Bell
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholls
authors.forename: C
authors.initials: C
authors.lastname: Norman
authors.forename: K
authors.initials: K
authors.lastname: Cooper
authors.forename: G M
authors.initials: GM
authors.lastname: Cross
mesh_terms: D000336:Aerosols; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002645:Chickens; D004326:Drinking; D005260:Female; D009521:Newcastle Disease / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D014765:Viral Vaccines