title: Absence of a dose-fractionation effect on neoplastic transformation induced by fission-spectrum neutrons in C3H 10T1/2 cells.
abstract: We have investigated the effect of fission-spectrum neutron dose fractionation on neoplastic transformation of exponentially growing C3H 10T1/2 cells. Total doses of 10.8, 27, 54, and 108 cGy were given in single doses or in five equal fractions delivered at 24-h intervals in the biological channel of the RSV-TAPIRO reactor at CRE-Casaccia. Both cell inactivation and neoplastic transformation were more effectively induced by fission neutrons than by 250-kVp X rays. No significant effect on cell survival or neoplastic transformation was observed with split doses compared to single doses of fission-spectrum neutrons. Neutron RBE values relative to X rays determined from data for survival and neoplastic transformation were comparable.
authors.affiliation: Laboratory of Pathology, E.N.E.A., CRE-Casaccia, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saran
authors.forename: S
authors.initials: S
authors.lastname: Pazzaglia
authors.forename: M
authors.initials: M
authors.lastname: Coppola
authors.forename: S
authors.initials: S
authors.lastname: Rebessi
authors.forename: V
authors.initials: V
authors.lastname: Di Majo
authors.forename: M
authors.initials: M
authors.lastname: Garavini
authors.forename: V
authors.initials: V
authors.lastname: Covelli
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D009502:Neutrons; D009680:Nuclear Fission; D009688:Nuclear Reactors