title: Dose-ranging study to delineate the additive antihypertensive effect of guanabenz and captopril.
abstract: This open crossover study in eight hypertensive patients defined a possible additive effect of oral guanabenz and captopril and determined a safe and effective dose range. Each group of four patients received placebo followed by ascending doses (on alternate days) of either guanabenz (2, 4, 8 mg) or captopril (6.25, 12.5, 25 mg) as initial monotherapy and were subsequently crossed over to the alternate monotherapy. Guanabenz and captopril were given concomitantly in increasing doses--the highest dose for both groups being 8 mg guanabenz/25 mg captopril. When guanabenz and captopril were given concomitantly, blood pressure decreased, both from the values during placebo administration and from the lead-in values recorded before each dose. Mean supine systolic and diastolic blood pressures after combination therapy decreased significantly (P less than .05) in a dose-related manner at most evaluations. The authors conclude that guanabenz and captopril have an additive effect when administered in combination to patients with hypertension.
authors.affiliation: Department of Medicine, University of Miami, Florida.
authors.forename: M A
authors.initials: MA
authors.lastname: Baez
authors.forename: R B
authors.initials: RB
authors.lastname: Woo-Ming
authors.forename: D C
authors.initials: DC
authors.lastname: Garg
authors.forename: D B
authors.initials: DB
authors.lastname: Shapse
authors.forename: M W
authors.initials: MW
authors.lastname: Deitch
authors.forename: D J
authors.initials: DJ
authors.lastname: Weidler
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000008:administration & dosage* / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006143:Guanabenz / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D002216:Captopril; D006143:Guanabenz