Application of a high-performance liquid chromatography coulometric method for the estimation of mebendazole and its metabolites in human sera.
A novel, sensitive high-performance liquid chromatographic method, making use of coulometric detection, for the estimation of mebendazole and its metabolites in the sera of eight hydatidosis patients was devised. Recovery rates, precision, accuracy and sensitivity for each compound are reported and compared with those of the previously published methods.
Betto
P
P
Istituto Superior di Sanità, Laboratorio di Chimica del Farmaco, Rome, Italy.
Gianbenedetti
M
M
Ponti
F
F
Ferretti
R
R
Settimj
G
G
Gargiulo
M
M
Lorenzini
R
R
D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004443:Echinococcosis / Q000188:drug therapy; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D008832:Microchemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D007202:Indicators and Reagents; D008463:Mebendazole