title: Bradykinin modulates the release of noradrenaline from vas deferens nerve terminals.
abstract: To asses whether bradykinin influences the release of noradrenaline from the adrenergic varicosities of the vas deferens, tissues were loaded with 3H-noradrenaline. Upon electrical depolarization bradykinin increased in a concentration-dependent fashion, the overflow of tritium from the mouse or rat vas deferens. The 3H-overflow is dependent on the external Ca2+concentration suggesting neuronal release of 3H-noradrenaline. The present results add evidence to the hypothesis that bradykinin modulates the release of noradrenaline from peripheral sympathetic nerve terminals via the activation of a presynaptic mechanism.
authors.affiliation: Laboratory of Biochemical Pharmacology, Faculty of Biological Sciences, Catholic University of Chile, Santiago.
authors.forename: I
authors.initials: I
authors.lastname: Llona
authors.forename: X
authors.initials: X
authors.lastname: Galleguillos
authors.forename: J
authors.initials: J
authors.lastname: Belmar
authors.forename: J P
authors.initials: JP
authors.lastname: Huidobro-Toro
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000032:analysis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism; D014649:Vas Deferens / Q000294:innervation / Q000378:metabolism*
chemical_list: D011941:Receptors, Adrenergic; D001920:Bradykinin; D002118:Calcium; D009638:Norepinephrine