Antihyperlipidemic effect of flavonoids from Prunus davidiana.
Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-catechin, prunin (= naringenin 7-O-glucoside), and hesperetin 5-O-glucoside. Administration of the MeOH extract for 3 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. (+)-Catechin was shown to be effective in reducing the elevated level of triglyceride. Prunin and hesperetin 5-O-glucoside did not show such an effect in high-fat-fed hypertriglyceridemic rats, but they did exhibit a significant hypocholesterolemic effect.
Choi
J S
JS
Department of Nutrition and Food Science, National Fisheries University of Pusan, Korea.
Yokozawa
T
T
Oura
H
H
D000818:Animals; D002392:Catechin / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005916:Globulins; D006569:Hesperidin / Q000031:analogs & derivatives*; D006949:Hyperlipidemias / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D015394:Molecular Structure; D010940:Plant Proteins; D010944:Plants / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D005419:Flavonoids; D005916:Globulins; D008055:Lipids; D010940:Plant Proteins; C039828:prunin protein, Prunus; C069231:hesperetin 5-O-glucoside; D002392:Catechin; D006569:Hesperidin