title: Magnetic fields associated with spreading depression in anaesthetised rabbits.
abstract: Magnetic fields were measured with SQUID magnetometry outside the skull of anaesthetised rabbits during initiation and propagation of spreading depression (SD) in the cortex. Slowly changing fields (up to 1.4 pT) were observed during the propagation phase, from 4-8.5 min after initiation of SD with KCl application, with maxima at about 6 min. The peak amplitude of the equivalent net dipole generators in the brain was ca. 28 microA.mm, substantially less than previously observed with SD in vitro, but large enough that similar signals might be detectable in man.
authors.affiliation: Neurology Department, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: A R
authors.initials: AR
authors.lastname: Gardner-Medwin
authors.forename: N
authors.initials: N
authors.lastname: Tepley
authors.forename: G L
authors.initials: GL
authors.lastname: Barkley
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: S
authors.initials: S
authors.lastname: Nagel-Leiby
authors.forename: R T
authors.initials: RT
authors.lastname: Simkins
authors.forename: K M
authors.initials: KM
authors.lastname: Welch
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D013181:Cortical Spreading Depression; D008280:Magnetics; D008433:Mathematics; D008959:Models, Neurological; D011189:Potassium Chloride; D011817:Rabbits
chemical_list: D011189:Potassium Chloride