title: Effect of sequential early burn wound excision and closure on postburn oxygen consumption.
abstract: OBJECTIVE
  To determine the effect of early excision and closure of burns on postburn hypermetabolism, measured as oxygen consumption (VO2).
  
  
  METHODS
  Twelve patients with deep burns of 30% to 50% of total body surface underwent sequential excisions and wound coverage, beginning 1 to 3 days after burn. The majority of the deep burn was removed by day 7, but with the addition of a donor site area of 20% to 25% of total body surface.
  
  
  RESULTS
  No decrease in VO2 was noted in relation to the percent removal of burn tissue. In addition, a transient further increase in VO2 was noted early after excision, especially with surgical procedures performed after 5 days. This response could not be attributed to wound manipulation-induced bacteremias.
  
  
  CONCLUSIONS
  We conclude that early surgical excision and closure of burns in excess of 30% to 50% of total body surface do not decrease postburn hypermetabolism in proportion to the area closed. It is possible that remaining open wounds in the form of donor sites and nonexcised burn are sufficient to perpetuate the hypermetabolic process, once established.
authors.affiliation: Longwood Area Trauma Center, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: R H
authors.initials: RH
authors.lastname: Demling
authors.forename: E
authors.initials: E
authors.lastname: Frye
authors.forename: T
authors.initials: T
authors.lastname: Read
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D001830:Body Surface Area; D001831:Body Temperature; D002056:Burns / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D010101:Oxygen Consumption; D011446:Prospective Studies; D012720:Severity of Illness Index; D016038:Skin Transplantation / Q000592:standards*; D015996:Survival Rate