Inhibition of protein kinase C arrests proliferation of human tumors.
We have shown that inhibition of protein kinase C by 1-5-isoquinolinylsulfonyl-2-methylpiperazine, H7, induces differentiation and inhibits proliferation of Neuro 2a cells. We have now tested if H7 is able to inhibit proliferation of: 1) human tumor cell lines from tissues other than brain; and 2) primary cultured cells from several human brain tumors. H7 inhibits, in a dose-dependent manner, proliferation of all human tumor cell lines tested and of primary cultured cells from human brain tumors. These results indicate that inhibition of protein kinase C inhibits proliferation of tumoral cells, therefore, H7, and likely other inhibitors of protein kinase C, could be useful in the clinical treatment of brain (and probably other) tumors.
Miñana
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MD
Instituto de Investigaciones Citológicas, Centro Asociado del CSIC, Valencia, Spain.
Felipo
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Cortés
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F
Grisolía
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S
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D001859:Bone Neoplasms; D001932:Brain Neoplasms; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects*; D007546:Isoquinolines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D012208:Rhabdomyosarcoma; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007546:Isoquinolines; D010879:Piperazines; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C