title: Treatment of Trichophyton mentagrophytes infection in rabbits.
abstract: Copper sulfate and a metastabilized chlorous acid/chlorine dioxide (MECA) compound were evaluated for efficacy in treating Trichophyton mentagrophytes infection in rabbits. Forty rabbits naturally infected with T mentagrophytes were allotted to 5 treatment groups: nontreated control, sham dip, 1% copper sulfate dip, MECA dip, and MECA spray. Results of lesion culture, regression of gross lesions, and histopathologic findings were documented. Copper sulfate and MECA were effective in treating clinical dermatophytosis and in decreasing T mentagrophytes carrier status in rabbits.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211.
authors.forename: C L
authors.initials: CL
authors.lastname: Franklin
authors.forename: S V
authors.initials: SV
authors.lastname: Gibson
authors.forename: C J
authors.initials: CJ
authors.lastname: Caffrey
authors.forename: J E
authors.initials: JE
authors.lastname: Wagner
authors.forename: E K
authors.initials: EK
authors.lastname: Steffen
mesh_terms: D000287:Administration, Topical; D000336:Aerosols; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage / Q000627:therapeutic use*; D002713:Chlorine / Q000008:administration & dosage / Q000627:therapeutic use*; D017606:Chlorine Compounds; D003300:Copper / Q000008:administration & dosage / Q000627:therapeutic use*; D019327:Copper Sulfate; D004202:Disinfectants / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D008297:Male; D010087:Oxides / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D014005:Tinea / Q000188:drug therapy / Q000662:veterinary*; D014249:Trichophyton / Q000302:isolation & purification
chemical_list: D000336:Aerosols; D002712:Chlorides; D017606:Chlorine Compounds; D004202:Disinfectants; D010087:Oxides; D002713:Chlorine; D003300:Copper; C063160:chlorous acid; C025109:chlorine dioxide; D019327:Copper Sulfate