[Experimental and clinical studies of coronary circulation after administration of mildronate].
In experiments on dogs, application of the cross-over circulation method revealed that mildronate increased coronary blood flow due to active coronary dilation. In experiments on cats, a cardioprotective effect of mildronate was found, which prevented the development of acute ischemic heart failure by stabilizing the major hemodynamic parameters. Clinical studies of patients with Functional Classes I-III angina provided evidence for positive effects of mildronate on coronary blood flow.
Savchuk
V I
VI
Novikova
E B
EB
Zhemerikina
E V
EV
Lobzeva
V I
VI
Seregin
E O
EO
D000328:Adult; D000368:Aged; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D008763:Methylhydrazines; D014665:Vasodilator Agents; C050147:3-(2,2,2-trimethylhydrazine)propionate
Eksperimental'noe i klinicheskoe issledovanie koronarnogo krovoobrashcheniia pri primenenii mildronata.