Role of MHC and antigens in T-cell development.
The role of self-peptides in influencing the development of the T-cell repertoire has been the focus of recent studies. The findings suggest that the recognition of self-peptides bound to MHC proteins in the thymus is part of the thymic self-recognition process that results in selective maturation, or positive selection of T cells.
Murphy
K M
KM
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110.
D000818:Animals; D006649:Histocompatibility Antigens / Q000276:immunology*; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000502:physiology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell