Sleep deprivation-induced neuronal damage may be due to nicotinic acid depletion.
Prolonged sleep deprivation induces chromatolysis of central nervous system neurons. This unusual form of neuronal damage is curiously similar to the neuronal damage seen in pellagra. It is proposed that the neuronal damage of prolonged sleep deprivation is a consequence of nicotinic acid depletion.
Reimund
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Department of Pathology, Tulane University School of Medicine, New Orleans, LA 70112.
D002490:Central Nervous System / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009243:NAD / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D009525:Niacin / Q000172:deficiency*; D012892:Sleep Deprivation / Q000502:physiology*
D009243:NAD; D009525:Niacin