[Nephrotoxicity of aminoglycosides. III. Preventive studies with subcutaneous administration of converting enzyme inhibitor, captopril].
The effect was studied of the converting enzyme inhibitor (captopril) on the gentamicin nephrotoxicity in rats. Captopril 25 mg/kg b.w. and gentamicin 100 mg/kg b.w. were injected subcutaneously in a single daily dose. Three groups of Wistar male rats were studied: 1) treated with gentamicin 3 and 7 days, 2) treated with gentamicin and captopril, 3) treated with captopril. The mean serum creatinine and urea levels and proteinuria in the second group were significantly higher than in the first one. Light and electron microscopy examinations demonstrated increased renal cortex damage in the second group. There were not differences between mean urea and creatinine levels in the third examined group and normal rats. Mechanism of gentamicin nephrotoxicity enhancement in the second group is unknown.
Niemczyk
S
S
Kliniki Chorób Wewnetrznych, AM w Warszawie.
Ludwicka
A
A
Groniowski
M
M
Lewandowski
Z
Z
Hasse
Z
Z
Stopiński
M
M
D000818:Animals; D002216:Captopril / Q000008:administration & dosage*; D005839:Gentamicins / Q000633:toxicity*; D007279:Injections, Subcutaneous; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005839:Gentamicins; D002216:Captopril
Nefrotoksyczność aminoglikozydów. Cześć III. Próby zapobiegania podskórnym podawaniem blokera enzymu konwertujacego, kaptoprylu szczurom.