[Rhino-sinusal immunology].
Nose and sinus pathology is frequently related to a chronic inflammation, the mechanisms of which involve different cell types that form the MALT, or effector cells. B-lymphocytes are three times more numerous than the T-lymphocytes, where the CD4+ cells predominate over the CD8+ cells. IgA's are mainly secreted by the plasmocytes. In IgA deficiency, a relative increase in IgG or IgD plasmocytes has been recorded. Antigenic information is obtained from cells presenting the antigen. Langerhans-like cells have been described. Two different populations of mast cells have been identified, whilst on the contrary eosinophilic cells are normally absent. The particularities of capillary vascularization and the extent of the nerve fibre network contribute to the creation of a micro-environment interacting with the lymphocytes. The phenomena of cellular interaction are described through the dynamic evolution of the IgE-dependent response in allergic rhinitis.
Moneret-Vautrin
D A
DA
Médecine D, Immunologie Clinique et Allergologie, C.H.R.U. de Nancy, Hôpital de Brabois, Vandoeuvre, France.
Jankowski
R
R
Wayoff
M
M
D006801:Humans; D009297:Nasal Mucosa / Q000276:immunology*; D010256:Paranasal Sinuses / Q000276:immunology*; D012220:Rhinitis / Q000276:immunology; D012852:Sinusitis / Q000276:immunology
Immunologie rhino-sinusienne.