The effect of lysophosphatidylcholine on coronary and renal circulation in the rabbit.
It has been shown that different lysophosphatidylcholines (LPC) possess relaxing properties in vascular strips. We report on the effect of intraatrial injection of LPC micelles into white New Zealand rabbits. Changes in renal and coronary flow were determined by radioactive microspheres. Coronary blood flow increased significantly following administration of LPC, while no significant changes were observed in renal blood flow, cardiac output and myocardial contractility. Coronary, renal and total vascular resistance, as well as mean arterial pressure, dropped significantly. Cardiac arrhythmia and hemolysis were not noted. The results demonstrate the vasorelaxant effect of LPC in vivo.
Wolf
A
A
Huntington Medical Research Institutes, Department of Experimental Cardiology, Pasadena, California 91105.
Saito
T
T
Dudek
R
R
Bing
R J
RJ
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation; D006439:Hemodynamics; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008297:Male; D008823:Micelles; D008863:Microspheres; D011817:Rabbits; D012079:Renal Circulation; D014655:Vascular Resistance
D008244:Lysophosphatidylcholines; D008823:Micelles