Diazepam: effect on multiple electroacupuncture-induced changes in regional GABA of mammalian central nervous system.
Single-dose diazepam (5 mg/kg i.p.) which increases central GABAergic activity alone normalizes the 6 multiple electroacupuncture (EA) (10 Hz, 1 volt, 10 min/day)-induced inhibition of GABAergic activity in Th and PM and thus reduces the EAA of adult male albino rats (120 +/- 10 g). On the contrary, single diazepam (5 mg/kg, i.p.) treatment to 15 multiple EA-(10 Hz, 1 volt, 10 min/day) exposed rats normalizes the 15 multiple EA-induced increase in thalamic GABAergic activity and fails to alter inhibition of GABAergic activity in CC and SC of 15 multiple EA-exposed rats. These results, thus, may be well correlated with the disinhibition of the 15 multiple EA-induced inhibition of analgesic response (assessed in terms of tail flick latency) with single diazepam treatment.
Chakrabarti
S
S
Department of Biochemistry, University of Calcutta, India.
Ganguly
A
A
Poddar
M K
MK
D000698:Analgesia; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003975:Diazepam / Q000494:pharmacology*; D015671:Electroacupuncture; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D003975:Diazepam