title: How to draw kinetic barrier diagrams for enzyme-catalysed reactions.
abstract: A modified way to construct kinetic barrier diagrams is presented. Although the diagram superficially resembles a free-energy profile, it is independent of any conception derived from transition-state theory. Some simple calculations referring to the lactate dehydrogenase turnover reaction at equilibrium demonstrate self-consistency of the diagram and its direct relevance to the results of numerical simulations of the detailed course of enzyme-catalysed reactions.
authors.affiliation: Abteilung Toxkologie, Christian-Albrechts-Universität, Kiel, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Südi
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008433:Mathematics; D008962:Models, Theoretical; D009243:NAD / Q000378:metabolism
chemical_list: D004798:Enzymes; D009243:NAD; D007770:L-Lactate Dehydrogenase