title: Wilson's disease: computed tomography and magnetic resonance imaging findings.
abstract: The condition of a patient with Wilson's disease was evaluated by magnetic resonance imaging (MRI) on initial presentation of the illness. The examination revealed mild atrophy of the superior vermis. Symmetric areas of increased signal intensity on T2-weighted images were detected in the anterior thalami, mesencephalic tectum and tegmentum. Marked symmetric hypointensities appeared in the head of caudate, pallida, substantia nigra and red nuclei. The histopathology of Wilson's disease suggests that these hypointensities may be secondary to the presence of protein-bound copper.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Hospital, McGill University, Montreal, Que.
authors.forename: A
authors.initials: A
authors.lastname: Abdollah
authors.forename: D
authors.initials: D
authors.lastname: Tampieri
authors.forename: D
authors.initials: D
authors.lastname: Melanson
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed