Distribution of Cu and induction of Cu-metallothionein in mice treated with Cu-nitrilotriacetic acid.
Slightly higher levels of copper were incorporated into the liver in copper-nitrilotriacetic acid (Cu-NTA)-treated mice than in CuSO4-treated mice. There was no difference in the distribution of Cu in hepatic subfractions between the two groups. In the cytosol fraction, however, metallothionein (MT) was significantly decreased in the Cu-NTA-treated mice. Excretion of Cu from liver to bile and blood was not changed in the two groups. The poor induction of MT by Cu-NTA supports the possibility that the compound is more harmful than CuSO4.
Sugawara
N
N
Department of Public Health, Sapporo Medical College, Japan.
Sugawara
C
C
Katakura
M
M
D000818:Animals; D003300:Copper / Q000378:metabolism*; D005609:Free Radicals; D006527:Hepatolenticular Degeneration / Q000209:etiology; D008099:Liver / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D008813:Mice, Inbred ICR; D009571:Nitrilotriacetic Acid / Q000633:toxicity*
D005609:Free Radicals; C007121:copper thionein; D003300:Copper; D008668:Metallothionein; D009571:Nitrilotriacetic Acid