Desferrioxamine ameliorates retinal photic injury in albino rats.
Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.
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Department of Ophthalmology, University of Illinois, Chicago College of Medicine.
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D000818:Animals; D002452:Cell Count; D003676:Deferoxamine / Q000627:therapeutic use*; D008027:Light / Q000009:adverse effects*; D008264:Macrophages / Q000473:pathology; D010786:Photoreceptor Cells / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012162:Retinal Degeneration / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D003676:Deferoxamine