title: Disposition of xenobiotic chemicals and metabolites in marine organisms.
abstract: Studies with several bottom fish species from urban waterways show that of the identified xenobiotic chemicals in bottom sediments, polycylic aromatic hydrocarbons (PAHs) are the most strongly associated with the prevalence of liver lesions, including neoplasms. Accordingly, there is concern about the transfer of contaminants, such as PAHs, from aquatic species to humans. Because PAHs exert their toxicity only after being biotransformed, increasing attention has been focused on the ability of aquatic organisms to metabolize these chemicals. Overall, the results of both laboratory and field studies show that generally low levels (nanograms per gram wet weight) of a few low molecular weight PAHs may be present in edible tissue of fish from contaminated areas and that high molecular weight PAHs, such as the carcinogen benzo(a)pyrene, will rarely be detected because of extensive metabolism. Additionally, the results from a few studies suggest that even though interactions between xenobiotics can affect both biochemical and physiological systems to alter the disposition of PAHs in fish, these interactions do not markedly change the relative proportions of metabolites to parent PAH in tissues. Thus, these studies clearly demonstrate that to obtain some insight into the questions of whether there is any risk to human health from consuming fish and crustaceans from urban areas, techniques must be developed that measure metabolites of carcinogens, such as PAHs, in edible tissue. Initial attempts may focus on semiquantitative methods that permit rapid assessment of the level of metabolites in edible tissues of fish and crustaceans from many urban areas.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Environmental Conservation Division, National Oceanic and Atmospheric Administration, Seattle, WA 98112.
authors.forename: U
authors.initials: U
authors.lastname: Varanasi
authors.forename: J E
authors.initials: JE
authors.lastname: Stein
mesh_terms: D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism / Q000493:pharmacokinetics*; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis; D011083:Polycyclic Compounds / Q000378:metabolism / Q000493:pharmacokinetics*; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D002273:Carcinogens; D011083:Polycyclic Compounds; D014874:Water Pollutants, Chemical