Mastoparan induces hypothermia in mice.
The polypeptide mastoparan, isolated from the venom of the Oriental Hornet, Vespa orientalis, induces hypothermia in white mice 15 minutes after its intraperitoneal injection. The hypothermic effect is induced by mastoparan obtained from different hornet and wasp venoms. The normal murine core temperature is lowered by mastoparan from 38 degrees C to as far as 33 degrees C. This lowering lasts for one hour and is reversible.
Duvdevani
P
P
Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Ramat Aviv, Israel.
Ishay
J S
JS
Schejter
A
A
D000595:Amino Acid Sequence; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D007035:Hypothermia / Q000139:chemically induced*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010455:Peptides; D014862:Wasp Venoms / Q000302:isolation & purification / Q000633:toxicity*; D014863:Wasps
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D014862:Wasp Venoms; C037500:mastoparan