title: Intramuscular sulbactam/ampicillin combination therapy in gynaecological and obstetric bacterial infections.
abstract: Estimates were carried out on the clinical and bacteriological efficacy of an intramuscular combination of sulbactam/ampicillin, together with an assessment of its tolerability and safety in the treatment of gynaecological and obstetric infections. A total of 30 women with pelvic inflammatory disease, wound infections, vaginitis and puerperal sepsis received an intramuscular combination of sulbactam/ampicillin in a total daily dose of 1.5 g for between 3 and 7 days. Clinical cure and improvement were achieved in 27 (90%) cases but there was no response in three (10%) cases. No side-effects were seen in 29 (97%) cases, whereas tolerable local injection site pain was reported in one case. The safety of the sulbactam/ampicillin antibiotic combination was evident in all the cases studied, as there was no significant difference between the means of laboratory tests before and after therapy of blood and renal measures.
authors.affiliation: Department of Gynaecology and Obstetrics, Faculty of Medicine, Cairo University, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: Abbassi
authors.forename: A
authors.initials: A
authors.lastname: Said
authors.forename: A
authors.initials: A
authors.lastname: Gaber
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D013407:Sulbactam / Q000008:administration & dosage*
chemical_list: C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam