title: Craniofacial growth in bone marrow transplant recipients treated with growth hormone after total body irradiation.
abstract: The effect of growth hormone (GH) treatment on craniofacial development was studied in five children exhibiting growth retardation following bone marrow transplantation. Linear and angular measurements were made on lateral radiographic cephalograms taken prior to the start of GH treatment and after an average treatment time of 1.2 yr. The results showed that the mean growth increments of mandibular length in the GH treated children, exceeded the corresponding values of the control group by 150% during the period of investigation. It is suggested that this dimensional increase in the patients was due to GH stimulation on the chondral growth process in the mandibular condyles.
authors.affiliation: Department of Pedodontics, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
authors.forename: C M
authors.initials: CM
authors.lastname: Forsberg
authors.forename: M
authors.initials: M
authors.lastname: Näsman
authors.forename: T
authors.initials: T
authors.lastname: Mattsson
authors.forename: T
authors.initials: T
authors.lastname: Modéer
authors.forename: B
authors.initials: B
authors.lastname: Borgström
authors.forename: P
authors.initials: P
authors.lastname: Bolme
authors.forename: O
authors.initials: O
authors.lastname: Ringdén
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D016026:Bone Marrow Transplantation; D002508:Cephalometry; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000254:growth & development; D008335:Mandibular Condyle / Q000187:drug effects / Q000254:growth & development; D008445:Maxillofacial Development / Q000187:drug effects / Q000528:radiation effects; D012399:Rotation; D014916:Whole-Body Irradiation
chemical_list: D013006:Growth Hormone