title: Characterization of dose-response relationships inferred by statistically significant trend tests.
abstract: A method is proposed for classifying various experimental outcomes associated with statistically significant trend tests according to a set of sequential testing within a family of closed (under intersections) one-sided tests. The intent of the procedure is to characterize the general shape of implied dose-response relationships, taking care neither to inflate the false-positive (Type I) error rate by overtesting, nor to sacrifice power by overadjusting for multiple comparisons.
authors.affiliation: National Center for Toxicological Research, Jefferson, Arkansas 72079.
authors.forename: R L
authors.initials: RL
authors.lastname: Kodell
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000818:Animals; D001699:Biometry; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D009374:Neoplasms, Experimental / Q000139:chemically induced
chemical_list: D002273:Carcinogens