title: Clinical experience in gynecological cancer management. c). Cervical cancer: report from the Gynecologic Institutes of Padua University (1963-1989).
abstract: The retrospective analysis of 1876 cases of invasive cervical cancer allows some considerations and conclusions on the clinical management of this neoplasia. Always led by the Gynaecologist, in the aims of prophylaxis and early diagnosis, personalized screening are necessary, with regard to risk factors. Surgical Pathological Staging (SPS) is mandatory for adequate treatment and prognosis. By personalizing surgical radicality and avoiding the application, in all cases, of the routine and standard extended operations of the past, it may be possible to reduce the complication rate with 5 year survival rate unchanged. In early stages personalized radical operations with systemic pelvic lymphadenectomy allow the best results (94% 5 year survival rate). Integrated therapies must be planned only in lymph nodal positive or in vascular space invasion cases. In advanced cases, surgery must be personalized in enlarged operations and integrated with adjuvant treatments on the basis of surgical pathological findings. In very advanced stages, integrated therapies, even without surgery, are justified, due to the poor prognosis of these cases.
authors.affiliation: Gynecologic Institute, University of Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Onnis
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
authors.forename: T
authors.initials: T
authors.lastname: Maggino
authors.forename: J
authors.initials: J
authors.lastname: De Toffoli
authors.forename: M
authors.initials: M
authors.lastname: Piazza
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D005544:Forecasting; D006801:Humans; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000517:prevention & control / Q000628:therapy*