title: Clinical evaluation of the use of decalcified freeze-dried bone allograft with guided tissue regeneration in the treatment of molar furcation invasions.
abstract: The purpose of this study is to evaluate the potential of decalcified freeze-dried bone allograft (DFDBA) combined with a barrier material in the treatment of human molar furcation defects (experimental) as compared to the barrier technique alone (control). Fifteen pairs of Class II or III furcation invasion defects comprised the study group. Measurements with calibrated periodontal probes were made to determine soft tissue recession, probing depth, and attachment levels. Defects from each pair were randomly selected to be treated with an expanded polytetrafluoroethylene membrane (e-PTFE) and DFDBA or the membrane alone. Additional measurements were made during surgery to determine crestal resorption, and vertical and horizontal open probing attachment. The membrane was removed 4 to 6 weeks post-insertion. Six months post-treatment, each site was surgically reentered and measurements repeated. Following either treatment, recession was minimal with statistically significant improvement in probing depth reduction and clinical attachment level gain favoring the combined technique. Hard tissue changes were comparable for alveolar crestal resorption, however, there was a distinct difference, statistically, for both horizontal and vertical bone repair favoring the use of the demineralized bone graft in combination with the e-PTFE membrane.
authors.affiliation: Department of Periodontics, Naval Dental School, Bethesda, MD.
authors.forename: C R
authors.initials: CR
authors.lastname: Anderegg
authors.forename: S J
authors.initials: SJ
authors.lastname: Martin
authors.forename: J L
authors.initials: JL
authors.lastname: Gray
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
authors.forename: M E
authors.initials: ME
authors.lastname: Gher
mesh_terms: D016025:Bone Transplantation / Q000379:methods; D003648:Decalcification Technique; D005069:Evaluation Studies as Topic; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008963:Molar; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D010518:Periodontitis / Q000473:pathology / Q000601:surgery*; D010519:Periodontium / Q000502:physiology*; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants; D012038:Regeneration; D013524:Surgical Flaps; D014021:Tissue Preservation; D014092:Tooth Root
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene