title: [Drug interactions in the prescriptions of patients before and after a heart infarct: results of the MONICA Augsburg heart infarct registry].
abstract: The prescriptions of 603 patients who had survived acute myocardial infarction (AMI) for at least one year and were registered from 1 Oct 84 to 31 Dec 86 in the Coronary Event Register of the MONICA project Augsburg were analyzed for the presence of drug-drug interactions with the aid of a computerized drug information system (SMA). Prior to AMI, 59% of patients were treated (average of 2 active substance per patient), 100% were treated on release from hospital (4.5 active substances), and 96% one year after AMI (5.8 active substances). Potential drug-drug interactions were found in 18% of patients before AMI, 65% on discharge from hospital, and 66% one year after AMI. While the potential frequency and severity of interactions are minor on average, prescriptions frequently contain several interactions. Calculations show that at least 5-6% of all prescriptions after AMI will produce interactions, so that drug safety for this high-risk patient group can be enhanced by a drug information system. Beta-blockers are the substance group most frequently involved in potential interactions in AMI patients.
authors.affiliation: GSF-MEDIS-Institut, Neuherberg bei München.
authors.forename: M
authors.initials: M
authors.lastname: Lewis
authors.forename: H
authors.initials: H
authors.lastname: Löwel
authors.forename: J
authors.initials: J
authors.lastname: Stieber
authors.forename: R
authors.initials: R
authors.lastname: Engelbrecht
authors.forename: A
authors.initials: A
authors.lastname: Hörmann
authors.forename: J
authors.initials: J
authors.lastname: John
mesh_terms: D000328:Adult; D000368:Aged; D002317:Cardiovascular Agents / Q000378:metabolism / Q000494:pharmacology*; D016208:Databases, Factual; D004346:Drug Information Services; D004347:Drug Interactions; D011307:Drug Prescriptions; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D002317:Cardiovascular Agents
vernacular_title: Arzneimittelwechselwirkungen in den Verordnungen von Patienten vor und nach dem Herzinfarkt: Resultate des MONICA Augsburg Herzinfarktregisters.