Inhibition of clastogenic effects of cesium chloride in mice in vivo by chlorophyllin.
The antagonistic effect of chlorophyllin was tested in reducing the clastogenic action of cesium chloride (CsCl) in vivo on mice bone marrow cells. CsCl induced chromosomal aberration in frequencies directly proportional to the dose administered. Chlorophyllin, when given alone, was not clastogenic even at a concentration of 1.5 mg/kg body wt. of the animal. Simultaneous administration of chlorophyllin and CsCl reduced chromosomal aberrations significantly at 24 h. Exposure to the same dose of chlorophyllin 2 h before exposure to CsCl also decreased clastogenic effects but to a lesser extent. These findings are of importance in view of the uptake of radioactive Cs by green plants after nuclear fallout.
Ghosh
A
A
Department of Botany, University of Calcutta, India.
Sen
S
S
Sharma
A
A
Talukder
G
G
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002586:Cesium / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002712:Chlorides; D002735:Chlorophyllides / Q000008:administration & dosage / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005260:Female; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D009153:Mutagens / Q000037:antagonists & inhibitors*
D002712:Chlorides; D002735:Chlorophyllides; D009153:Mutagens; D002586:Cesium; C007020:chlorophyllin; C028019:cesium chloride