Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.
Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan.
Lerner
E A
EA
Department of Dermatology, Harvard Medical School, Boston, Massachusetts.
Ribeiro
J M
JM
Nelson
R J
RJ
Lerner
M R
MR
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D004175:Diptera; D004586:Electrophoresis; D004591:Electrophoresis, Polyacrylamide Gel; D004890:Erythema / Q000139:chemically induced; D007301:Insect Hormones / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D019476:Insect Proteins; D007525:Isoelectric Focusing; D013058:Mass Spectrometry; D011817:Rabbits; D011994:Recombinant Proteins / Q000633:toxicity; D012469:Salivary Glands / Q000737:chemistry*; D014665:Vasodilator Agents / Q000302:isolation & purification
D000596:Amino Acids; D007301:Insect Hormones; D019476:Insect Proteins; D011994:Recombinant Proteins; D014665:Vasodilator Agents; C069147:maxadilan protein, insect; D015740:Calcitonin Gene-Related Peptide