Microemulsions for improved peptide absorption from the gastrointestinal tract.
Results on gastrointestinal absorption of three peptides, insulin, cyclosporin from microemulsions, obtained from studies in our laboratories during the past years have been summarized. The routes of administration were period, intralumenal or rectal. The experiments were carried out in dogs, rabbits and rats. An absorption model for peptides using microemulsions as delivery systems is presented.
Ritschel
W A
WA
University of Cincinnati Medical Center, OH.
D000284:Administration, Oral; D000285:Administration, Rectal; D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose; D004285:Dogs; D004655:Emulsions; D007328:Insulin / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D010455:Peptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D014018:Tissue Distribution
D001786:Blood Glucose; D004655:Emulsions; D007328:Insulin; D010455:Peptides