Relationship between blood-oxygen affinity and blood volume.
The hypothesis was tested that total blood volume (TBV) is correlated with hemoglobin oxygen affinity. Intraspecifically Hb-O2 affinity was manipulated in rats using NaOCN. Interspecifically the hypothesis was evaluated using data gathered from the literature. Both intra- and interspecifically TBV increased with increasing hemoglobin oxygen affinity (delta TBV/delta P50 = -1.18). Intraspecifically decreases in P50 were associated with an increase in red blood cell mass and hematocrit. Interspecifically plasma volume had an inverse relationship with Hb-O2 affinity (delta TBV/delta P50 = -1.10) and hematocrit showed no changes. These data suggest that an increased blood volume may be part of the mechanism explaining the inverse correlation between P50 and hypoxic tolerance.
Birchard
G F
GF
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire.
Tenney
S M
SM
D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013223:Statistics as Topic
D006454:Hemoglobins; D010100:Oxygen