Four unusual cases of sudden and unexpected cardiovascular death in infancy and childhood.
Four unusual cases of sudden and unexpected cardiovascular death in infancy and early childhood that were found during a ten-year autopsy review at our institutions are presented. In Case 1, an asymptomatic 2-year-old male, sudden death resulted from an acute myocardial infarct due to occlusion of coronary arteries that had been previously damaged by unsuspected arteritis. Case 2, a previously well 7-month-old male, died from an acute myocardial infarct due to an unsuspected anomalous origin of the coronary arteries from a single, stenotic coronary ostium. Case 3, a previously well 21-month-old black male, died from a splenic sequestration crisis due to undiagnosed sickle cell disease. Case 4, a 2-month-old female with suspected Marfan syndrome, died from a ruptured dissecting aneurysm of a patent ductus arteriosus. Accuracy of diagnosis was of particular importance in the latter two cases because of the possible genetic implications.
Byard
R W
RW
Department of Histopathology, Adelaide Children's Hospital, Australia.
Jimenez
C L
CL
Carpenter
B F
BF
Cutz
E
E
Smith
C R
CR
D002318:Cardiovascular Diseases / Q000150:complications* / Q000473:pathology; D002675:Child, Preschool; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male