[Determination of fentanyl concentrations in the blood with the application of high performance liquid chromatography].
We developed a method to determine the blood concentration of fentanyl by using reverse phase partition liquid chromatography. The extract rate of fentanyl from blood 10 ml was 79 +/- 2%, and the minimum detective concentration of fentanyl was 158 pg.ml-1. These performances are sufficient to determine the blood concentration of fentanyl in clinical anesthesia.
Tsuchiya
M
M
Department of Anesthesiology, Kochi Medical School, Nankoku.
Ueda
W
W
Tomoda
M
M
Hirakawa
M
M
D000776:Anesthesiology / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D005283:Fentanyl / Q000097:blood*; D006801:Humans
D005283:Fentanyl