[Anticonvulsive effects of neurotropin].
The antiepileptic action of neurotropin (Nippon Zoki Pharmaceutied Co. Ltd., Japan) was investigated in acute experiments on rats, mice and cats. The increasing of latent period of the first seizures which were picrotoxin-induced and enhancing of this type of seizures were observed correspondently in 1-24 hours and 8-9 days after intraventricular neurotropin injection. Intraperitoneal neurotropin injection (0.2-0.5 ml) to mice caused dosage-dependent antiseizure action on the model of generalized picrotoxin-induced seizures. +Anticonvulsant++ effect of neurotropin was observed during five days. The intraventricular neurotropin injection to cats led to strychnine (0.1%) induced cortical foci suppression.
Shandra
A A
AA
Sudakov
K V
KV
Kryzhanovskiĭ
G N
GN
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002415:Cats; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010852:Picrotoxin; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D010852:Picrotoxin; D011134:Polysaccharides; C010491:neurotropin
Protivosudorozhnye éffekty neĭrotropina.