title: Maternal cocaine abuse and necrotizing enterocolitis: outcome and survival.
abstract: Since 1987, multiple complications related to maternal cocaine abuse have been reported. Necrotizing enterocolitis-(NEC) of the newborn has been observed with increasing frequency. We report a comparative analysis of infants with NEC born to cocaine abusing mothers (n = 11) to a standard population of newborns with NEC (n = 50) treated in this institution from January 1987 to July 1989. We also evaluated whether prenatal cocaine abuse predisposes infants to NEC by performing a case-control analysis using 51 of 61 infants and controls matched for race, sex, and birthweight +/- 250g. Significant differences were apparent between the cocaine-affected infants (COC) and the noncocaine-affected infants (Non-COC) with regard to surgical intervention (72.7% v 38%, P less than .05), the presence of massive gangrene (54% v 12%, P less than .01), mortality (54.5% v 18%, P less than .01), and maternal age (28.13 +/- 3.82 years v 24.12 +/- 6.21 years P less than .05). No differences between these groups could be demonstrated for other known NEC risk factors such as gestational age, birthweight, feeding patterns, umbilical artery catheters, or asphyxia. In the matched case-control study, infants born to mothers who were cocaine abusers demonstrated a 2.5-fold increased risk of developing NEC (95% Cl = 1.17 to 5.32, P = .02) when compared with the noncocaine-exposed group. Maternal cocaine abuse appears to play a contributory role in the pathogenesis of NEC, its extent, and its outcome.
authors.affiliation: Department of Surgery, Children's Hospital of Philadelphia, PA 19104.
authors.forename: C
authors.initials: C
authors.lastname: Czyrko
authors.forename: C A
authors.initials: CA
authors.lastname: Del Pin
authors.forename: J A
authors.initials: JA
authors.lastname: O'Neill
authors.forename: G J
authors.initials: GJ
authors.lastname: Peckham
authors.forename: A J
authors.initials: AJ
authors.lastname: Ross
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003042:Cocaine; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005734:Gangrene / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D008431:Maternal-Fetal Exchange; D016017:Odds Ratio; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D019966:Substance-Related Disorders; D016019:Survival Analysis
chemical_list: D003042:Cocaine