title: Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.
abstract: We compared the relative toxicities of standard concentrations of two magnetic resonance imaging (MRI) contrast agents, ionic gadolinium diethylenetriaminepentacetic acid (DTPA) and low-osmolar gadolinium-1, 4, 7 tris (carboxymethyl)-10-(2'-hydroxypropyl)-1, 4, 7, 10 tetra-azacyclododecane (HP-DO3A) with that of the conventional radiographic contrast medium meglumine diatrizoate, when extravasated into the deep dermal tissues of laboratory rats. Gadolinium-DTPA caused moderate necrosis, hemorrhage, and edema which was not statistically different than meglumine diatrizoate. In contrast, gadolinium HP-DO3A was significantly less toxic than meglumine diatrizoate. Additional experience will be needed in order to determine whether these laboratory results will be clinically relevant in humans.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina.
authors.forename: R H
authors.initials: RH
authors.lastname: Cohan
authors.forename: R A
authors.initials: RA
authors.lastname: Leder
authors.forename: A J
authors.initials: AJ
authors.lastname: Herzberg
authors.forename: L W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: C T
authors.initials: CT
authors.lastname: Wheeler
authors.forename: C A
authors.initials: CA
authors.lastname: Beam
authors.forename: S N
authors.initials: SN
authors.lastname: Nadel
authors.forename: N R
authors.initials: NR
authors.lastname: Dunnick
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005682:Gadolinium / Q000633:toxicity*; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds / Q000633:toxicity*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D009994:Osmolar Concentration; D004369:Pentetic Acid / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D003974:Diatrizoate Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA