title: Natural killer function in the rat with interstitial nephritis.
abstract: Brown Norway (BN) rats with tubulointerstitial nephritis (TIN) have an augmented NK activity. Immunological manifestations of the disease indicate the existence of a highly activated B-cell system, as reflected in the high levels of circulating antibodies and in the predominant spontaneous IgG-producing B-cells in cultures. In addition, NK cells appear to induce positive signals for antibody production either when co-cultured with B-cells alone or after treatment with poly I:C. Our results suggest that NK cells might play a role in the immunoregulation of the humoral response in this disease.
authors.affiliation: Department of Pathology, Hospital Ramon y Cajal, Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Bricio
authors.forename: F
authors.initials: F
authors.lastname: Mampaso
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003524:Cyclosporins / Q000008:administration & dosage; D003601:Cytotoxicity Tests, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D009395:Nephritis, Interstitial / Q000276:immunology*; D011070:Poly I-C / Q000008:administration & dosage; D051381:Rats; D011914:Rats, Inbred BN; D013154:Spleen / Q000276:immunology
chemical_list: D003524:Cyclosporins; D007074:Immunoglobulin G; D011070:Poly I-C