title: Epidemiological and pathological studies of a familial thymic lymphosarcoma in bovine species.
abstract: A total of 216 cases of the thymic form of bovine leukosis were observed in Holstein calves in several departments of France over a period of 18 months. Almost all of these calves were sired by the same bull. The calves were negative for bovine leukemia virus-specific antibodies. Morphological studies, including light and electron microscopic cytology, and immunophenotyping were performed in 38 cases. The tumor cells exhibit membrane markers (T-cell antigens) at variable levels, which indicate that they are T-lymphoid derived. The cells are maintained at a very early stage of differentiation as indicated by TdT enzyme activity and the presence of MHC class II antigen.
authors.affiliation: Laboratoire d'Anatomie Pathologique-INRA, Ecole Nationale Vétérinaire, Alfort, France.
authors.forename: B
authors.initials: B
authors.lastname: Da Costa
authors.forename: S
authors.initials: S
authors.lastname: Djilali
authors.forename: J L
authors.initials: JL
authors.lastname: Kessler
authors.forename: B
authors.initials: B
authors.lastname: Sacré
authors.forename: F
authors.initials: F
authors.lastname: Femenia
authors.forename: A L
authors.initials: AL
authors.lastname: Parodi
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D005260:Female; D005602:France / Q000453:epidemiology; D016131:Lymphocyte Subsets / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013953:Thymus Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D004254:DNA Nucleotidyltransferases