title: Interaction between the left-handed Z-DNA and polyamine. The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex.
abstract: The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24], a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 A resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: S
authors.initials: S
authors.lastname: Kunisawa
authors.forename: G
authors.initials: G
authors.lastname: van der Marel
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
authors.forename: A
authors.initials: A
authors.lastname: Rich
authors.forename: A H
authors.initials: AH
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Hakoshima
mesh_terms: D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D006860:Hydrogen Bonding; D008274:Magnesium / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D009838:Oligodeoxyribonucleotides; D010710:Phosphates; D011073:Polyamines; C069659:N-(2-aminoethyl)-1,4-diaminobutane; C041751:tri(deoxycytidylic acid-deoxyguanylic acid); D004247:DNA; D012964:Sodium; D008274:Magnesium