Interleaved 1H and 31P spectroscopic imaging for studying regional brain injury.
We present a new approach for in vivo localized spectroscopy which combines 1H and 31P one-dimensional spectroscopic imaging pulse sequences in an interleaved, time-shared manner using a surface coil. This approach was used to acquire metabolic information from a rat brain with regional ischemia at 4.7 Tesla. Spectra with very good signal-to-noise ratios, void of chemical shift artifacts, are obtainable from voxel sizes less than 0.3 cm3 in 40 min. Advantages and drawbacks of the proposed methodology are discussed.
Chang
L H
LH
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143.
Cohen
Y
Y
Weinstein
P R
PR
Chileuitt
L
L
James
T L
TL
D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000175:diagnosis* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010758:Phosphorus / Q000378:metabolism; D051381:Rats
D007773:Lactates; D010758:Phosphorus; D019344:Lactic Acid