Do endogenous excitatory amino acids influence striatal dopamine release?
In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 microM was without an effect on basal dopamine release while 100 microM and 1 mM of these drugs significantly enhanced the release. Our findings do not support the idea that excitatory amino acids have a tonic excitatory effect on striatal dopamine release.
Moghaddam
B
B
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510.
Gruen
R J
RJ
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D016202:N-Methylaspartate; D004298:Dopamine