[Mutagenic and gonadotoxic effects of a primer NTs-0192].
Mutagenic and gonadotoxic effects of the primer H -0192 were studied. It was shown, that acute exposure of male rats to substances, migrating from the paint, caused gonadotoxic effect in mature sex cells of animals. Evidence of mutagenic effect was observed in the truncal cells alongside with a gonadotoxic effect. Chronic exposure to a mixture of chemicals, migrating from the primer cover, caused changes characteristic of mutagenic and gonadotoxic effects in sex cells at different stages of spermatogenesis, no disturbances were found in the truncal cells. Somatic cells (bone marrow cells) under the conditions of both types of exposure did not suffer damage.
Fedorchuk
S Ia
SIa
Gus'kova
S I
SI
Bokov
A N
AN
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006066:Gonads / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests; D010150:Paint / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013997:Time Factors
Mutagennoe i gonadotoksicheskoe deĭstvie gruntovochnogo sostava NTs-0192]