title: Group C streptococcal bacteremia: analysis of 88 cases.
abstract: Eighty-eight cases of group C streptococcal bacteremia were reviewed retrospectively. Most patients had underlying diseases (72.7%), predominantly cardiovascular disease (20.5%) or malignancy (20.5%). The infection originated most often from the upper respiratory tract (20.5%), the gastrointestinal tract (18.2%), or the skin (17.1%). Prior exposure to animals or animal products was reported in 23.9% of cases. The most common clinical manifestations of group C streptococcal bacteremia were endocarditis (27.3%), primary bacteremia (22.7%), and meningitis (10.2%). Of streptococcal isolates, 61.4% were not speciated, 19.3% were Streptococcus equisimilis, 17.1% were Streptococcus zooepidemicus, and two (2.3%) were Streptococcus equi. The isolates were sensitive to most antibiotics, and most patients were treated with beta-lactam agents. Mortality was high (25.0%), especially among older patients and patients with endocarditis, meningitis, and disseminated infection. Group C streptococcal bacteremia does not differ from bloodstream infection caused by other beta-hemolytic streptococci with regard to clinical presentation, treatment, or outcome.
authors.affiliation: Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan 48105.
authors.forename: S F
authors.initials: SF
authors.lastname: Bradley
authors.forename: J J
authors.initials: JJ
authors.lastname: Gordon
authors.forename: D D
authors.initials: DD
authors.lastname: Baumgartner
authors.forename: W A
authors.initials: WA
authors.lastname: Marasco
authors.forename: C A
authors.initials: CA
authors.lastname: Kauffman
mesh_terms: D004697:Endocarditis, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008581:Meningitis; D008875:Middle Aged; D012189:Retrospective Studies; D018805:Sepsis; D012874:Skin Diseases, Infectious; D013290:Streptococcal Infections