title: [Intake of disopyramide led to diagnosis of insulinoma].
abstract: A single dose of 250 mg disopyramide provoked severe hypoglycaemia and confusion in a 75-year-old woman. During subsequent investigation, fasting provoked symptomatic hypoglycaemia (venous blood glucose, 1.6 mumol/1) after 23 hours, plasma concentrations of insulin and C peptide then being 19 micrograms/ml and 0.85 pmol/l, respectively; computerised tomography and ultrasonography of the pancreas n.a.d. However, at laparotomy, a 10 mm diameter insulinoma was detected by intra-operative ultrasonography and palpation. The tumour was removed. To our knowledge, this is the first reported case of an insulinoma being detected due to intake of disopyramide.
authors.affiliation: endokrinologiska kliniken, Akademiska sjukhuset, Uppsala.
authors.forename: M
authors.initials: M
authors.lastname: Alvarsson
authors.forename: V
authors.initials: V
authors.lastname: Grill
authors.forename: B
authors.initials: B
authors.lastname: Hamberger
authors.forename: L
authors.initials: L
authors.lastname: Grimelius
mesh_terms: D000368:Aged; D004206:Disopyramide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007340:Insulinoma / Q000097:blood / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D004206:Disopyramide
vernacular_title: Intag av disopyramid ledde till insulinomdiagnos.