Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.
Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-mediated autoregulation. We have shown that modulation of receptor gene expression contributes to the responsiveness of adrenergic and related receptors. Recent evidence for post-transcriptional regulation, as well as the stimulation of transcription in an autoregulatory manner, indicates the unanticipated variety and complexity of mechanisms regulating adrenergic receptor responsiveness.
Collins
S
S
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.
Caron
M G
MG
Lefkowitz
R J
RJ
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011941:Receptors, Adrenergic / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
D011941:Receptors, Adrenergic