PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
Using PIVKA-II and Hepaplastin test, 5 neonates exposed to anticonvulsant drugs in utero were assessed 5 days after birth. None showed any sign of clinical bleeding, but all had PIVKA-II values over 1 microgram/ml. In controls, only 96 of 1,166 (8.2%) neonates had PIVKA-II values over 1 microgram/ml. The difference in the incidence rate was significant (p less than 0.005). Three of 5 epileptic mothers received valproatic acid and/or diazepam but no barbiturates and/or hydantoin.
Anai
T
T
Department of Obstetrics and Gynecology, Medical College of Oita.
Hirota
Y
Y
Oga
M
M
Yoshimatsu
J
J
Miyakawa
I
I
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D015415:Biomarkers; D003975:Diazepam / Q000009:adverse effects; D004827:Epilepsy / Q000188:drug therapy; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications; D011498:Protein Precursors / Q000032:analysis*; D011516:Prothrombin / Q000032:analysis*; D014635:Valproic Acid / Q000009:adverse effects; D014813:Vitamin K Deficiency / Q000175:diagnosis* / Q000209:etiology
D000927:Anticonvulsants; D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D014635:Valproic Acid; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X; D003975:Diazepam