title: Synthesis and pharmacological properties of 3-alkylthio derivatives of isothiazolothieno-1,2,3-triazine.
abstract: Some 3-alkylthio- derivatives of 7-chloroisothiazolothieno-1,2,3-triazine and of isothiazolothieno-1,2,3-triazin-7(4H)one were prepared. The synthesized compounds were subjected to pharmacological screening for antiallergic, antiinflammatory and analgesic activity as well as to a microbiological test in order to evaluate potential antifungal activity.
authors.affiliation: Instituto di Chimica Farmaceutica e Tossicologica-Università di Catania, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Guerrera
authors.forename: M C
authors.initials: MC
authors.lastname: Sarvà
authors.forename: M A
authors.initials: MA
authors.lastname: Siracusa
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: M G
authors.initials: MG
authors.lastname: Leone
authors.forename: V
authors.initials: V
authors.lastname: Cutuli
authors.forename: S
authors.initials: S
authors.lastname: Oliveri
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D006633:Histamine Antagonists; D013844:Thiazoles; D013876:Thiophenes; D014227:Triazines