title: The preparation and properties of bromoacetylphosphonic acid.
abstract: Bromoacetylphosphonic acid, Br-CH2-CO-PO3H2, was made by brominating dimethyl acetylphosphonate and de-esterifying with HBr. It proves to be a powerful alkylating agent, reacting rapidly with GSH, with a rate constant of about 6M(-1).s(-1) at pH6.
authors.affiliation: Department of Biochemistry, University of Cambridge, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sparkes
authors.forename: H B
authors.initials: HB
authors.lastname: Dixon
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D009943:Organophosphorus Compounds; C069017:bromoacetylphosphonate; D005978:Glutathione