title: Unusual causes of I-131 metaiodobenzylguanidine uptake in non-neural crest tissue.
abstract: Three patients with clinical suspicion of pheochromocytoma were studied with metaiodobenzylguanidine (MIBG) labeled with I-123 or I-131. In these three patients, marked uptake of the radiopharmaceutical was demonstrated in tissues that were subsequently proven not to be of neural crest origin. Furthermore, extensive biochemical evaluations and long-term followup definitively excluded pheochromocytoma in all three. Therefore, these three cases represent unexpected "false-positive" MIBG uptake.
authors.affiliation: Department of Nuclear Medicine, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Horne
authors.forename: B
authors.initials: B
authors.lastname: Glaser
authors.forename: Y
authors.initials: Y
authors.lastname: Krausz
authors.forename: D
authors.initials: D
authors.lastname: Rubinger
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
mesh_terms: D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging*; D000328:Adult; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine