title: [Synchronous cancers of the esophagus and of the ORL area: results of combined treatments with esophagectomy (28 cases)].
abstract: Twenty-eight patients with synchronous esophageal and head and neck epidermoid cancers have been treated by a combined protocol including esophagectomy. Seventy-nine percent received pre-operative chemotherapy, 50% had resection of the head and neck lesion at the same time as the esophagectomy and 79% received post-operative irradiation. Two patients died during the post-operative period (7%), and 1, 2 and 3-yr survival rate (Kaplan-Meier) was respectively 64, 32 and 27%. Contrary to our initial assumption, there was no significant decrease in survival compared to patients operated on for an isolated esophageal cancer. The patients were divided into 4 very simple prognostic groups based on the T and N stages of the clinical pre-therapeutic TNM classification: T1 or T2 for esophageal lesions and different T or N stages according to the prognosis for head and neck lesions. A study of each group tended to show that esophagectomy was beneficial except in cases of synchronous T2 esophageal cancer and locally advanced head and neck cancer (there was 2-yr survival in this group). The 28 patients studied represent a particular population which presented 91 cancerous localisations during the duration of the study (mean: 3.25 localisations per patient).
authors.affiliation: Service de chirurgie digestive carcinologique, Institut Gustave-Roussy, Villejuif, France.
authors.forename: D
authors.initials: D
authors.lastname: Elias
authors.forename: G
authors.initials: G
authors.lastname: Mamelle
authors.forename: O
authors.initials: O
authors.lastname: el Malt
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
authors.forename: G
authors.initials: G
authors.lastname: Schwaab
authors.forename: M
authors.initials: M
authors.lastname: Spielmann
authors.forename: T
authors.initials: T
authors.lastname: Girinsky
authors.forename: G
authors.initials: G
authors.lastname: Nitenberg
authors.forename: J
authors.initials: J
authors.lastname: Kac
authors.forename: P
authors.initials: P
authors.lastname: Lasser
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000401:mortality / Q000628:therapy*; D004947:Esophagus / Q000601:surgery*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000401:mortality / Q000628:therapy*; D010039:Otorhinolaryngologic Neoplasms / Q000401:mortality / Q000628:therapy*; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
vernacular_title: Cancers synchrones de l'oesophage et de la sphère ORL: résultats des traitements combinés avec oesophagectomie (28 cas).