Muscle morphogenesis in the absence of myogenic cells.
Experimental evidence indicates, that the myogenic cells themselves are not responsible for the muscle pattern formation. We report on a chance observation that reveals that muscle pattern formation can occur even in the absence of myogenic cells. Epiblastic cells from a quail embryo in the primitive streak stage were implanted into the wing bud of a chick embryo. The grafted quail cells developed into mononucleate, fibroblast-like cells that formed the muscle belly of the extensor medius longus muscle. This showed essentially normal form and topography as revealed by computer-aided 3D-reconstruction. This finding shows, that the formation of muscles does not depend on the presence of myogenic cells.
Grim
M
M
Institute of Anatomy, Charles University, Prague, CSFR.
Wachtler
F
F
D000818:Animals; D003198:Computer Simulation; D009024:Morphogenesis; D009132:Muscles / Q000196:embryology*; D011784:Quail / Q000196:embryology*; D014921:Wings, Animal / Q000196:embryology