title: Potential markers of the atherosclerotic process in high-risk children.
abstract: Children whose parents had early coronary heart disease were investigated. In order to assess high-risk parameters serum total cholesterol (TC), total triglyceride (TT), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), lipid peroxide (LP), prostacyclin (PGI2), thromboxane (TX) levels, and the distribution of the complement 3 (C3), protein phenotypes were measured. Compared to a group of control children, the offspring of high-risk subjects had increased LDLC, LP, TC, and TX levels, a higher incidence of fast-slow heterozygotes, and decreased HDLC and PGI2 levels. The measurement of serum PGI2, TX levels and the distribution of C3 protein phenotypes may give further information about the true risk of atherosclerosis.
authors.affiliation: Department of Pediatrics No. 2, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: T
authors.initials: T
authors.lastname: Szamosi
authors.forename: K
authors.initials: K
authors.lastname: Mihai
authors.forename: J
authors.initials: J
authors.lastname: Peto
authors.forename: A
authors.initials: A
authors.lastname: Makary
authors.forename: J
authors.initials: J
authors.lastname: Kramer
mesh_terms: D000293:Adolescent; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000378:metabolism; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003176:Complement C3 / Q000378:metabolism; D003327:Coronary Disease / Q000175:diagnosis; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010641:Phenotype; D012307:Risk Factors; D013931:Thromboxanes / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D003176:Complement C3; D008054:Lipid Peroxides; D008075:Lipoproteins, HDL; D013931:Thromboxanes; D014280:Triglycerides; D002784:Cholesterol; D011464:Epoprostenol