Inhibition of electrical activity in mouse pancreatic beta-cells by the ATP/ADP translocase inhibitor, bongkrekic acid.
Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic beta-cell through the stimulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing beta-cell function.
Kiranadi
B
B
University Laboratory of Physiology, Oxford, UK.
Bangham
J A
JA
Smith
P A
PA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001865:Bongkrekic Acid / Q000633:toxicity*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects*; D051379:Mice; D008928:Mitochondria / Q000201:enzymology; D000226:Mitochondrial ADP, ATP Translocases / Q000037:antagonists & inhibitors*; D015221:Potassium Channels / Q000187:drug effects
D015221:Potassium Channels; D001865:Bongkrekic Acid; D000255:Adenosine Triphosphate; D000226:Mitochondrial ADP, ATP Translocases