Effects evoked by pentamethylenetetrazol-induced seizures upon N-acetylaspartate and N-acetylaspartylglutamate levels in different regions of the rat neuraxis.
We have examined the effects evoked by pentamethylenetetrazol (PTZ)-induced seizures upon the concentration of N-acetylaspartate (NAA) and of N-acetylaspartylglutamate (NAAG) in the forebrain, brainstem and spinal cord of rats. We observed a significant decrease of both NAA and NAAG in each one of the studied regions. These findings are consistent with an inhibitory role proposed in CNS for NAA and NAAG.
Brancati
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A
Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy.
D'Arcangelo
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P
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D004151:Dipeptides; C027172:isospaglumic acid; D001224:Aspartic Acid; C000179:N-acetylaspartate; D010433:Pentylenetetrazole