Multiple control level governing H10 mRNA and protein accumulation.
We have studied the variation of histone H10 and of its coding mRNA during rat liver regeneration after partial hepatectomy. Our data showed that while H10 decreased when cell proliferation was initiated, H10 mRNA accumulated in a proliferation-dependent manner as did H3 mRNA. These results showed two interesting aspects of the regulation of H10 expression in vivo, confirming results we have obtained previously in vitro: first H10 mRNA accumulation is a proliferation-dependent event; second, H10 protein accumulation may be uncoupled from that of its coding mRNA.
Khochbin
S
S
Laboratoire de Biologie Moléculaire du Cycle Cellulaire, INSERM U 309, Département de Biologie Moléculaire et Structurale, Centre d'Etudes Nucléaires de Grenoble, France.
Gorka
C
C
Lawrence
J J
JJ
D000818:Animals; D015152:Blotting, Northern; D004261:DNA Replication; D004591:Electrophoresis, Polyacrylamide Gel; D006498:Hepatectomy; D006657:Histones / Q000235:genetics*; D008115:Liver Regeneration; D008297:Male; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006657:Histones; D011506:Proteins; D012333:RNA, Messenger