title: [Stability of beta-lactamase inhibitors and beta-lactam antibiotics in parenteral formulations as well as in body fluids and tissue homogenates. Comparison of sulbactam, clavulanic acid, ampicillin and amoxicillin].
abstract: Stability of beta-Lactamase Inhibitors and beta-Lactam Antibiotics in Parenteral Formulations as Well as in Body Fluids and Tissue Homogenates/Comparative studies with sulbactam, clavulanic acid, ampicillin and amoxicillin. The beta-lactamase inhibitors and the beta-lactam antibiotics are markedly different in chemical stability. The comparative examination of 4 different infusion solutions at 4 degrees C, 25 degrees C and 37 degrees C gives the following sequence of decreasing stability: sulbactam (CAS 68373-14-8), ampicillin (CAS 69-53-4), amoxicillin (CAS 61336-70-7) and clavulanic acid (CAS 58001-44-8). It is particularly striking that the two beta-lactamase inhibitors, sulbactam and clavulanic acid, behave very differently. Sulbactam is also much more stable than clavulanic acid to incubation at 37 degrees C in body fluids or in tissue homogenates. The differences in the stability of the individual drugs should be born in mind during clinical use of combination formulations such as sulbactam/ampicillin (Unacid) and clavulanic acid/amoxicillin.
authors.affiliation: Fakultät für Theoretische Medizin, Universität Ulm, Donau.
authors.forename: A
authors.initials: A
authors.lastname: Wildfeuer
authors.forename: K
authors.initials: K
authors.lastname: Räder
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000032:analysis; D000667:Ampicillin / Q000008:administration & dosage / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000032:analysis; D004355:Drug Stability; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D013407:Sulbactam / Q000008:administration & dosage / Q000032:analysis; D013696:Temperature; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam
vernacular_title: Stabilität von beta-Lactamase-Inhibitoren und beta-Lactam-Antibiotika in parenteralen Darreichungsformen sowie in Körperflüssigkeiten und Gewebehomogenaten. Vergleichende Untersuchung von Sulbactam, Clavulansäure, Ampicillin und Amoxicillin.