[A clinical study on pulmonary tissue uptake of flomoxef].
Based on the results of a study on pulmonary tissue uptake of flomoxef (FMOX), a new antibiotic agent, in 45 patients undergoing thoracotomy, the following conclusions were drawn: 1. Immediately preoperative 1 hour-drug infusion of 1 g FMOX led to maximum serum concentration (averaging 42.4 micrograms/ml) 1 hour later, with a half-life of its beta phase of 1.26 hours. 2. Normal lung (alveolar) tissue concentration was Cmax 17.98 micrograms/g with its ratios to serum peak value being 31.8, 27.1, 22.2, 9.4, 5.9 and 5.0% at 1, 2, 3, 4, 5 and 6 hours later, respectively. 3. Bronchiolar tissue concentration was Cmax 31.91 micrograms/g, with its ratios to serum peak value being 27.8, 19.3 and 10.1% at 2, 3 and 4 hours later, respectively, indicating its good bronchiolar intra-tissue transition. The above results suggested the usefulness of FMOX for both the treatment of respiratory infections and the prevention of postoperative infections.
Imaizumi
M
M
Department of Thoracic Surgery, School of Medicine, Nagoya University.
Watanabe
H
H
Ojika
T
T
Fujita
K
K
Sakakibara
M
M
Kondo
D
D
Nishimura
M
M
Abe
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000378:metabolism; D002511:Cephalosporins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011650:Pulmonary Alveoli / Q000378:metabolism; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism; D013908:Thoracotomy
D002511:Cephalosporins; C045693:flomoxef