Effect of certain additives on photodegradation of tetracycline hydrochloride solutions.
The photostability of tetracycline hydrochloride solutions in the presence of selected potential stabilizers under various light sources was investigated. Reduced glutathione (GSH) demonstrated the greatest photostabilizing effect followed by p-aminobenzoic acid (PABA), ethylenediamine tetraacetic acid (EDTA) disodium salt, DL-cysteine, thiourea, sodium thiosulfate, and DL-methionine in a descending order. The photostabilizing effect of GSH was found to be dependent on its concentration, pH and buffer species of the medium, the light source, and the temperature of the solutions exposed to light.
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College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee.
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D002021:Buffers; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010777:Photochemistry; D012996:Solutions; D013696:Temperature; D013752:Tetracycline / Q000737:chemistry*
D002021:Buffers; D005079:Excipients; D012996:Solutions; D013752:Tetracycline