LPS stimulated invertebrate hemocytes: a role for immunoreactive TNF and IL-1.
Mytilus edulis hemocytes have similarities with vertebrate monocyte/macrophages. We have recently shown that they respond to human TNF and IL-1. We tested the possibility that Mytilus hemocytes produce similar substances in response to LPS. We show that Mytilus hemocytes respond to LPS in a fashion similar to vertebrate monocytes and macrophages and that these responses are inhibited by antibodies to TNF and/or IL-1. These findings are demonstrated both in vitro and in vivo.
Hughes
T K
TK
Department of Microbiology, University of Texas Medical Branch, Galveston 77550.
Smith
E M
EM
Barnett
J A
JA
Charles
R
R
Stefano
G B
GB
D000818:Animals; D049872:Bivalvia / Q000276:immunology*; D006434:Hemocytes / Q000276:immunology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology
D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha