title: Central nervous system action of endothelin-3 to inhibit water drinking in the rat.
abstract: Endothelin-3, a vasoconstrictor peptide produced not only in endothelial cells but also within the brain interstitium in magnocellular neurons of the hypothalamo-neurohypophysial system, exerted significant, dose-related, inhibitory effects on water intake when administered into the third cerebroventricle of rats exposed to exogenous and endogenous stimuli for drinking. Passive immunoneutralization of endogenous endothelin-3 accentuated water drinking in response to angiotensin II administration suggesting a physiological role for the peptide in the central control of fluid and electrolyte homeostasis.
authors.affiliation: Department of Anatomy and Neurobiology, University of Missouri School of Medicine, Columbia 65212.
authors.forename: W K
authors.initials: WK
authors.lastname: Samson
authors.forename: K
authors.initials: K
authors.lastname: Skala
authors.forename: F L
authors.initials: FL
authors.lastname: Huang
authors.forename: S
authors.initials: S
authors.lastname: Gluntz
authors.forename: B
authors.initials: B
authors.lastname: Alexander
authors.forename: C E
authors.initials: CE
authors.lastname: Gómez-Sánchez
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D016232:Endothelins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016232:Endothelins; D000804:Angiotensin II