title: In vitro effects of tremorgenic mycotoxins.
abstract: Paxilline was isolated from Penicillium paxilli (NRRL 6110). It was studied together with penitrem B and verruculogen in the electrically stimulated guinea pig ileum. All three mycotoxins enhanced the electrically induced twitch contractions, without influencing the contractions provoked by exogenous acetylcholine. The effect of the mycotoxins could be greatly diminished by hyoscine. The possible mechanism of action of these substances in this in vitro model is discussed. The electrically stimulated guinea pig ileum could be useful in the detection and estimation of the biological activity of tremorgenic mycotoxins.
authors.affiliation: Department of Pharmaceutical Sciences, University of Antwerp (UIA), Belgium.
authors.forename: M I
authors.initials: MI
authors.lastname: Selala
authors.forename: G M
authors.initials: GM
authors.lastname: Laekeman
authors.forename: B
authors.initials: B
authors.lastname: Loenders
authors.forename: A
authors.initials: A
authors.lastname: Musuku
authors.forename: A G
authors.initials: AG
authors.lastname: Herman
authors.forename: P
authors.initials: P
authors.lastname: Schepens
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D015394:Molecular Structure; D009183:Mycotoxins / Q000494:pharmacology*
chemical_list: D009183:Mycotoxins; D000109:Acetylcholine