Increased serum conjugated dienes in elderly diabetic patients.
To determine if lipid peroxidation by-products are increased in the serum of elderly diabetic patients, serum concentrations of conjugated dienes were measured in 45 Type 2 diabetic men over the age of 60 years, and the results were compared to those of 24 age-matched healthy men. Patients with diabetic complications such as retinopathy, nephropathy, neuropathy, peripheral vascular disease, coronary or cerebrovascular disease, (n = 22) had significantly increased serum levels of conjugated dienes (0.4951 +/- 0.065 O.D./mL) compared to healthy controls (0.2368 +/- 0.028 O.D./mL) (P less than 0.01). The level of conjugated dienes in diabetic patients without complications (0.3854 +/- 0.0316 O.D./mL) was intermediate between the level found in control subjects and the level in patients with diabetic complications. The serum levels of conjugated dienes correlated best with serum triglyceride concentration (r = 0.51) and to a lesser extent with serum glucose concentration (r = 0.36). It is concluded that elderly patients with diabetes, especially those with complications, have increased serum levels of lipid peroxidation by-products. This can not be totally attributed to alterations in serum cholesterol, phospholipid, or triglyceride levels.
Mooradian
A D
AD
Tucson VA Medical Center, Arizona.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol