Sarcoidosis and major histocompatibility complex genes with special emphasis on BF F subtypes.
Frequencies for HLA class I and II histoglobulins and C4A, C4B, BF complement proteins were performed for 59 sarcoidosis patients. The DR5 allele was present in 55.9% of patients as compared to 31.5% of controls. We noticed that its increase was more relevant in males and in those with a poor prognosis. BF F allele was significantly over-represented in patients (29.09% vs. 19.15% of control), especially in women. Special emphasis was given to BF F subtyping, to define an association between a particular BF F subtype and patient's sex or disease outcome.
Finco
O
O
Dipartimento di Genetica e Microbiologia, Università di Pavia, Italia.
Martinetti
M
M
Dondi
E
E
Luisetti
M
M
Pasturenzi
L
L
Cuccia
M
M
D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D005260:Female; D005805:Genes, MHC Class I / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012507:Sarcoidosis / Q000235:genetics*; D012727:Sex Characteristics
D006680:HLA Antigens; D006681:HLA-D Antigens; D011415:Complement Factor B