title: Population dynamics of natural antibodies in normal and autoimmune individuals.
abstract: We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.
authors.affiliation: Centre National de la Recherche Scientifique, Ecole Polytechnique, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Varela
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: G
authors.initials: G
authors.lastname: Dietrich
authors.forename: A
authors.initials: A
authors.lastname: Sundblad
authors.forename: D
authors.initials: D
authors.lastname: Holmberg
authors.forename: M
authors.initials: M
authors.lastname: Kazatchkine
authors.forename: A
authors.initials: A
authors.lastname: Coutinho
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001323:Autoantibodies / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology*; D007107:Immune System / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D051379:Mice; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D013997:Time Factors
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes