Phylogenetic scanning: a computer-assisted algorithm for mapping gene conversions and other recombinational events.
An algorithm, 'phylogenetic scanning', is described for mapping gene conversion events where comparative DNA sequence data are available from different species. In this algorithm, sets of hypothetical phylogenetic trees are constructed that describe possible sequence relationships due to gene conversions in different species lineages; these trees are then evaluated by the principle of parsimony at intervals in the sequence alignment. When used to map gene conversion events that occurred between the pair of gamma-globin genes of higher primates, the algorithm gives results nearly identical to those obtained using a tedious manual approach. Suggestions are also provided for adaptation of this procedure to the analysis of other recombination events.
Fitch
D H
DH
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
Goodman
M
M
D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D005785:Gene Conversion / Q000502:physiology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D013045:Species Specificity