[Prevention of disorders of cardiomyocyte ultrastructure in experimental myocardial infarction in immobilization-induced stress by administration of thyroid hormones].
In the experiment, carried out on 48 non-inbred male rats ultrastructural changes in cardiomyocytes in non-ischemized parts of the heart at experimental infarction of myocardium under conditions of immobilization stress have been studied, as well as possibility to correct these changes by means of thyroid hormones. The stress intensifies dystrophic processes, developed outside the infarction zone, increases the mass of the necrotized tissue, essentially decreases the areas occupied by mitochondria and myofibrils, as well as their ratio in the section area. Small doses of thyroid hormones prevent the heart from the damaging effect of the stressor: decreasing area; occupied by mitochondria, myofibrils and their relation in the section, as well as they stimulate intracellular regenerative processes (accumulation of polymorphous mitochondria with clearly manifested cristae, membranes of the endoplasmic reticulum) and decrease the myocardial necrotized zone). Thus, structural lesions, resulted from the effect of ischemic necrosis and stress, can be prevented by small doses of thyroid hormones+.
Bozhko
A P
AP
Sukhorukova
T A
TA
Archakova
L I
LI
D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000517:prevention & control*; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology* / Q000523:psychology; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications*; D013963:Thyroid Hormones / Q000008:administration & dosage*
D013963:Thyroid Hormones; C004227:thyroidin
Preduprezhdenie tireoidnymi gormonami narusheniĭ ul'trastruktury kardiomiotsitov pri éksperimental'nom infarkte miokarda v usloviiakh immobilizatsionnogo stressa.