title: Ticlopidine lowers plasma fibrinogen in patients with polycythaemia rubra vera and additional thrombotic risk factors. A double-blind controlled study.
abstract: Thirty-seven patients affected by polycythaemia rubra vera (PRV) and with at least one additional thrombotic risk factor (overt vascular disease, diabetes mellitus, treated hypertension, smoking habit, plasma hyperviscosity, hyperfibrinogenemia) were enrolled in a double-blind randomized placebo-controlled study, and 18 were given ticlopidine 250 mg, b.i.d., for 60 days. All the patients had previously been submitted to cytoreduction, and PRV was under control in all cases at the start of the study. During the study, the haematological parameters were controlled every 15 days, and venesection was performed if haematocrit was greater than 46%. Whole blood viscosity, at low and high shear rates, plasma viscosity, and fibrinogen were measured on days 0 and 60. In the ticlopidine group, we recorded a significant 13.14% reduction of the mean fibrinogen level after treatment (390 +/- 63 vs. 449 +/- 97 mg/dl, p less than 0.01). All the other haemorheological parameters were not significantly modified by ticlopidine treatment, nor were there significant modifications recorded in the placebo group. Our study shows that ticlopidine may reduce a probable thrombotic risk factor (hyperfibrinogenemia) in PRV patients.
authors.affiliation: University Hospital S. Orsola, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Finelli
authors.forename: G
authors.initials: G
authors.lastname: Palareti
authors.forename: M
authors.initials: M
authors.lastname: Poggi
authors.forename: P
authors.initials: P
authors.lastname: Torricelli
authors.forename: N
authors.initials: N
authors.lastname: Vianelli
authors.forename: M
authors.initials: M
authors.lastname: Fiacchini
authors.forename: E
authors.initials: E
authors.lastname: Zuffa
authors.forename: P
authors.initials: P
authors.lastname: Ricci
authors.forename: L
authors.initials: L
authors.lastname: Gugliotta
authors.forename: S
authors.initials: S
authors.lastname: Coccheri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001809:Blood Viscosity / Q000187:drug effects; D004311:Double-Blind Method; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011087:Polycythemia Vera / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D013988:Ticlopidine / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D005340:Fibrinogen; D013988:Ticlopidine