title: Anaesthetic-induced ventricular tachyarrhythmia in Jervell and Lange-Nielsen syndrome.
abstract: A four-year-old deaf girl with a history of convulsions developed polymorphous ventricular tachycardia during induction of anaesthesia. The arrhythmia reverted to sinus rhythm spontaneously. Post-anaesthetic ECG showed marked prolongation of the QTc interval (570-690 msec). Deafness and prolonged QTc interval in association with microcytic-hypochromic anaemia confirmed the diagnosis of the Jervell and Lange-Nielsen syndrome. This case report highlights the potentially lethal complication of halothane anaesthesia in patients with long QTc interval syndrome.
authors.affiliation: Department of Anaesthesiology, King Faisal University, College of Medicine, Dammam, Saudi Arabia.
authors.forename: Y
authors.initials: Y
authors.lastname: Adu-Gyamfi
authors.forename: A
authors.initials: A
authors.lastname: Said
authors.forename: U M
authors.initials: UM
authors.lastname: Chowdhary
authors.forename: A
authors.initials: A
authors.lastname: Abomelha
authors.forename: S K
authors.initials: SK
authors.lastname: Sanyal
mesh_terms: D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004562:Electrocardiography; D004827:Epilepsy / Q000175:diagnosis; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006352:Heart Ventricles; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D013610:Tachycardia / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D006221:Halothane