Cellular models of atherosclerosis in the young.
The current interest in vascular lesions formed during childhood and adolescence is both pertinent and timely, as atherosclerosis research has never been more exciting that at the present. A number of attractive hypotheses about the pathogenesis of atherosclerosis have been proposed which provide different perspectives for understanding the disease process. A host of animal and cell models of early lesions are now available for study and new technological advances, such as recombinant DNA techniques and sensitive imaging procedures, will allow these models to be studied in greater depth. Consequently, the next decade should bring new insight on the pathogenesis of atherosclerosis, especially the early lesions of youth.
Fowler
S D
SD
Department of Pathology, School of Medicine, University of South Carolina, Columbia 29208.
Gasque-Carter
P D
PD
Pattillo-Adkisson
E
E
Sasiela
W J
WJ
Xenachis
D N
DN
D000293:Adolescent; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D048909:Diabetes Complications; D004195:Disease Models, Animal; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D009131:Muscle, Smooth, Vascular / Q000473:pathology