title: Nerve growth factor inhibits immunoglobulin production by but not proliferation of human plasma cell lines.
abstract: The effects of nerve growth factor (NGF) on human plasma cells were studied. NGF inhibited immunoglobulin (Ig) production but not thymidine uptake by human plasma cell lines IM-9 and AF-10 in a dose-dependent fashion. This NGF-induced inhibition of Ig production was specific, since inhibition was blocked by anti-NGF serum but not by control serum. Interleukin (IL)-6 did not affect Ig production by IM-9 and AF-10; however, IL-6 restored NGF-induced inhibition of Ig production. NGF also inhibited Ig production (IgG, IgM, and IgA) without affecting thymidine uptake by PCA-1+ plasma cells generated in vitro. This inhibition was also blocked by anti-NGF serum but not by control serum and was restored by IL-6. These results suggest that NGF may interact with IL-6 in control of Ig production by plasma cells.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kyoto University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kimata
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: C
authors.initials: C
authors.lastname: Ishioka
authors.forename: H
authors.initials: H
authors.lastname: Mikawa
mesh_terms: D002460:Cell Line; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000494:pharmacology*; D010950:Plasma Cells / Q000187:drug effects / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D015850:Interleukin-6; D009414:Nerve Growth Factors