Effect of cepharanthine on doxorubicin cytotoxicity in P388 murine leukemia cells in vitro and in vivo.
The effect of cepharanthine on the cytotoxicity of doxorubicin (DOX) in p388 leukemia cells was studied in vitro and in vivo. Nontoxic levels of cepharanthine enhanced the sensitivity to doxorubicin in p388 cells in vitro. The potentiation of antitumor activity of DOX by cepharanthine against mice bearing p388 cells was also observed.
Fujimura
T
T
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Furusawa
S
S
Kawauchi
H
H
Takayanagi
Y
Y
Sasaki
K
K
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D044182:Benzylisoquinolines; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; D004317:Doxorubicin; C006947:cepharanthine; D052117:Benzodioxoles