title: High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides gentamicin and apramycin.
abstract: Escherichia coli and Salmonella strains resistant to gentamicin and apramycin were isolated from cattle in France and Belgium and from patients in hospitals. Homology between plasmids of both human and animal origins encoding aminoglycoside 3-N-acetyltransferase was revealed by digestion with several restriction endonucleases and confirmed by hybridization with different replicon-specific probes.
authors.affiliation: Institut National de la Recherche Agronomique, Centre de Tours-Nouzilly, Monnaie, France.
authors.forename: E
authors.initials: E
authors.lastname: Chaslus-Dancla
authors.forename: P
authors.initials: P
authors.lastname: Pohl
authors.forename: M
authors.initials: M
authors.lastname: Meurisse
authors.forename: M
authors.initials: M
authors.lastname: Marin
authors.forename: J P
authors.initials: JP
authors.lastname: Lafont
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000235:genetics; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D009328:Nebramycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D009693:Nucleic Acid Hybridization; D010957:Plasmids / Q000187:drug effects* / Q000235:genetics; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics; D013552:Swine
chemical_list: D005839:Gentamicins; D009328:Nebramycin; C011666:apramycin; D004247:DNA