Comparison between evaluation methods for the anti-caries efficacy of monofluorophosphate-containing dentifrices.
A comparison is described of three methods of preclinical assessment of potential anti-caries efficacy for topical fluoride treatments. Methods are compared using dentifrices containing 1,000, 1,500 and 2,500 ppm F as sodium monofluorophosphate (SMFP). These formulations have been shown elsewhere to give a statistically significant dose response of increasing anti-caries efficacy [Stephen et al., 1988]. An in situ enamel insert model, oral fluoride pharmacokinetics and F uptake to demineralised enamel are all shown to correlate with clinical efficacy for the test dentifrices studied.
Raven
S J
SJ
Unilever Dental Research, Unilever Research Port Sunlight Laboratory, Bebington, UK.
Schäfer
F
F
Duckworth
R M
RM
Gilbert
R J
RJ
Parr
T A
TA
D000328:Adult; D000368:Aged; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000378:metabolism; D003802:Dentifrices / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012463:Saliva / Q000737:chemistry; D014089:Tooth Remineralization
D003802:Dentifrices; D005460:Fluorides, Topical; D010710:Phosphates; C012980:fluorophosphate; D005459:Fluorides