[HLA-antigens in patients with rheumatoid arthritis].
109 patients with rheumatoid arthritis (RA) from the north of the GDR were HLA typed and the antigen frequencies compared with those of a control group. Even in our patients the HLA-DR4 association was demonstrable. But in all studies DR4 association is not strong enough for taking HLA typing as a diagnostic test for RA. There was an immunogenetic heterogeneity in correlation to side effects of therapy with sodium aurothiomalate or D-penicillamine. HLA-DR5 was significantly increased in patients with side effects in comparison to patients without side effects in therapy. Before recommending HLA-DR typing for selection of high risk patients in D-penicillamine therapy these results should be proven in a large patient group or in a second study.
Wegener
S
S
Institut für Transfusionsmedizin, Bezirkskrankenhauses Rostock.
Bruhn
P
P
Keysser
M
M
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D008297:Male; D010641:Phenotype; D012307:Risk Factors
D006680:HLA Antigens; D015804:HLA-DR4 Antigen
HLA-Antigene bei Patienten mit Rheumatoid-Arthritis.