Effect of allopurinol on the hepatic and cerebellar iron, selenium, zinc and copper status following acute ethanol administration to rats.
An acute ethanol load (50 mmol/kg, i.p.) induces an increase in the total non-heme iron and in the low-molecular-weight non-heme iron complexes (LMW-Fe) content both in liver and cerebellum. This increase in LMW-Fe is associated with a decrease in some essential trace elements (selenium, zinc, copper) playing a role in the anti-oxidant system. These changes could contribute to the enhancement in lipid peroxidation which occurs at the hepatic and cerebellar level following the ethanol administration. The administration of allopurinol prior to the ethanol load prevents the changes in non-heme iron and trace elements. This prevention may contribute to the protective effects of allopurinol on the ethanol-induced oxidative stress.
Houze
P
P
Department of Biomedical Research on Alcoholism, University René Descartes, Paris, France.
Rouach
H
H
Gentil
M
M
Orfanelli
M T
MT
Nordmann
R
R
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D016166:Free Radical Scavengers; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014131:Trace Elements / Q000378:metabolism*
D016166:Free Radical Scavengers; D014131:Trace Elements; D000431:Ethanol; D000493:Allopurinol; D007501:Iron