title: Aortic valve morphology influences regurgitant volume in aortic regurgitation: in vitro evaluation.
abstract: OBJECTIVE
  According to the Gorlin hydraulic orifice equation, aortic regurgitation volume can be determined by the regurgitant orifice cross sectional area, diastolic filling period, mean pressure gradient between the aorta and left ventricle, and a constant relating the coefficients of contraction (Cc) and velocity (Cv). This study was performed to determine whether variation in aortic valve morphology affects regurgitant flow volume, Cc and Cv.
  
  
  METHODS
  Four aortic valve templates, modelled after circular, rheumatic, degenerative, and bicuspid lesions, were constructed with equal orifice cross sectional areas in two sizes, 0.2 and 0.7 cm2. These valves were studied in vitro in a flow model of aortic regurgitation, wherein aortic pressure was regulated by varying the height of a column of fluid. Flow, pressure, and velocity were measured, and the coefficient Cc and Cv were calculated from standard equations.
  
  
  RESULTS
  Regurgitant volume was assessed at diastolic filling periods of 0.5 and 1.0 s and averaged 15% greater for bicuspid and degenerative as compared to circular or rheumatic valve shapes (p = 0.0001). This difference was accentuated at the shorter diastolic filling time and higher pressure gradient, such that bicuspid lesions allowed 29% more regurgitant flow across the 0.2 cm2 orifice at fluid height of 120 cm over 0.5 s. This difference in regurgitant volume between valve shapes was due to an increased Cc for the bicuspid and degenerative valve shapes, suggesting that they are more efficient orifices than rheumatic or circular valve shapes.
  
  
  CONCLUSIONS
  Aortic valve morphology influences regurgitant volume in aortic regurgitation. Specifically, degenerative and bicuspid orifice shapes have a higher contraction coefficient and allow more regurgitant flow than rheumatic or circular orifices at a given driving pressure and diastolic filling time.
authors.affiliation: Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas 75216.
authors.forename: P A
authors.initials: PA
authors.lastname: Grayburn
authors.forename: E J
authors.initials: EJ
authors.lastname: Eichhorn
authors.forename: R C
authors.initials: RC
authors.lastname: Eberhart
authors.forename: J B
authors.initials: JB
authors.lastname: Bedotto
authors.forename: M E
authors.initials: ME
authors.lastname: Brickner
authors.forename: A L
authors.initials: AL
authors.lastname: Taylor
mesh_terms: D001021:Aortic Valve / Q000473:pathology*; D001022:Aortic Valve Insufficiency / Q000473:pathology* / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure; D006801:Humans; D008722:Methods; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology