[Cellular composition of structural components of the lymph nodes of rats during rehabilitation after dimethyl sulfate poisoning].
By means of microanatomical methods the inferior tracheobronchial lymph nodes have been investigated in 48 Wistar rats in 2 weeks and 3 months after discontinuance of inhalation of dimethylsulfate (DMS) vapours for 2 and 14 days by the animals in concentration 2.0 mg/m3, that is to say during rehabilitation period. Comparison of relative parameters of the structural components areas and cell composition of the lymph nodes has been carried out. During rehabilitation period after DMS inhalation for 2 days the cortical and medullary areas in histological preparations do not essentially differ from corresponding parameters of an acute experiment (2 days, 2.0 mg/m3, without rehabilitation). Amount (%) of cells with mitotic figures in the lymphoid nodules++ increases in 2 weeks and in 3 months. Contents of poorly differentiated cells during rehabilitation periods increase in the cortical plateau, but keeps nearly at the same low level as during the acute experiment in the lymphoid nodules++. In 2 weeks after DMS influence for 14 days, the cortical and medullary area in the histological preparations reach the control levels. In the lymphoid nodules++ a relative amount of reticular, poorly differentiated, mitotically dividing cells increases, and in the medullary cords contents of middle and small lymphocytes become greater in comparison with the acute experiment (14 days, 2.0 mg/m3, without rehabilitation).(ABSTRACT TRUNCATED AT 250 WORDS)
Sharova
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D000818:Animals; D002452:Cell Count / Q000187:drug effects; D004195:Disease Models, Animal; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012046:Rehabilitation; D013463:Sulfuric Acid Esters / Q000506:poisoning*; D013997:Time Factors
D013463:Sulfuric Acid Esters; C007482:dimethyl sulfate
Kletochnyĭ sostav strukturnykh komponentov limfaticheskikh uzlov krys v periody reabilitatsii posle vozdeĭstviia dimetilsul'fata.