title: Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1.
abstract: Marfan syndrome is a systemic disorder of the connective tissue inherited as an autosomal dominant trait. The disorder imparts significant morbidity and mortality. The etiology of the disorder remains elusive. A recent study localized the gene for Marfan syndrome on chromosome 15. We present data showing that marker D15S48 is genetically linked to Marfan syndrome. Pairwise linkage analysis gave a maximum lod (logarithm of odds) score of Z = 11.78 at theta = 0.02. Furthermore our data suggest that the Marfan syndrome locus is possibly flanked on either side by D15S48 and D15S49.
authors.affiliation: Department of Pediatrics, University of Connecticut Health Center, Farmington 06030.
authors.forename: P
authors.initials: P
authors.lastname: Tsipouras
authors.forename: M
authors.initials: M
authors.lastname: Sarfarazi
authors.forename: A
authors.initials: A
authors.lastname: Devi
authors.forename: B
authors.initials: B
authors.lastname: Weiffenbach
authors.forename: M
authors.initials: M
authors.lastname: Boxer
mesh_terms: D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008382:Marfan Syndrome / Q000235:genetics*
chemical_list: D005819:Genetic Markers