[Experimental analysis of the main stages of immunogenesis in severe polytrauma].
The condition of the main stages of immunogenesis was studied in F1 (CBA X C57Bl6) hybrid mice in the search for the means for correcting posttraumatic immunodeficiency in severe polytrauma. The response of the immune system to a severe polytrauma was characterized by the development of emergency adaptational and pathological processes. The migration of stem hematopoietic cells and T-lymphocytes increased, the inducing capacity of macrophages was intensified, the migration capacity of B-lymphocytes diminished in increase of their differentiation from pre-B-cells, the inhibiting activity of T-suppressors reduced. The humoral immune response is restricted against this background. Deficiency of T-cell helper function was the main pathogenetic factor in the formation of posttraumatic immunodeficiency. Replacement of this function by interleukin-2 may possibly be an effective method for correcting posttraumatic immunodeficiency.
Aleksandrov
V N
VN
Tukhvatulina
L K
LK
D000818:Animals; D005260:Female; D051379:Mice; D009104:Multiple Trauma / Q000276:immunology*
Eksperimental'nyĭ analiz osnovnykh étapov immunogeneza pri tiazheloĭ politravme.