title: Nocturnal cortisol, thyroid stimulating hormone, and growth hormone secretory profiles in depressed adolescents.
abstract: Twelve depressed adolescents and 12 controls matched for age, sex, Tanner stage, time of menstrual cycle (females), weight, and time of year assessed were studied over 3 nights. Measurements for cortisol, thyroid stimulating hormone, and growth hormone were made on serum collected at 10 P.M., 12 midnight, 1 A.M., 2 A.M., 3 A.M., 4 A.M., and 6 A.M. in eight pairs and every 20 minutes from 8 P.M. to 7 A.M. in four pairs. Cortisol secretion did not significantly differentiate the groups. Thyroid stimulating hormone secretion was significantly elevated in the depressed group at one time point. Growth hormone secretion significantly differentiated the two groups at most time points, and the depressed adolescents significantly hypersecreted growth hormone (area under the curve). Implications for the diagnosis, etiology, and treatment of adolescent depression are discussed.
authors.affiliation: Division of Adolescent Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Kutcher
authors.forename: D
authors.initials: D
authors.lastname: Malkin
authors.forename: J
authors.initials: J
authors.lastname: Silverberg
authors.forename: P
authors.initials: P
authors.lastname: Marton
authors.forename: P
authors.initials: P
authors.lastname: Williamson
authors.forename: A
authors.initials: A
authors.lastname: Malkin
authors.forename: J
authors.initials: J
authors.lastname: Szalai
authors.forename: M
authors.initials: M
authors.lastname: Katic
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000097:blood* / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D008297:Male; D013972:Thyrotropin / Q000097:blood* / Q000378:metabolism
chemical_list: D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone