A case of cerebellar medulloblastoma with a single chromosome abnormality.
In the few published karyotypes of human medulloblastoma, multiple chromosome abnormalities have usually been demonstrated. We report a case of medulloblastoma in which only a single structural alteration was observed, namely an unbalanced translocation between chromosomes 1 and 6 resulting in partial 1q trisomy and partial 6q mónosomy. This finding may help define genomic regions that are of importance in development of medulloblastoma.
Stratton
M R
MR
Department of Neuropathology, Institute of Psychiatry, London, England.
Darling
J
J
Cooper
C S
CS
Reeves
B R
BR
D002528:Cerebellar Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D008527:Medulloblastoma / Q000235:genetics*; D009006:Monosomy; D014178:Translocation, Genetic; D014314:Trisomy