SWR mice are resistant to collagen-induced arthritis but produce potentially arthritogenic antibodies.
SWR mice are resistant to collagen-induced arthritis but produce antibodies to type II collagen. To determine if these antibodies have arthritogenic potential, serum from collagen-immunized mice was concentrated and passively transferred to DBA/1 mice. The recipients developed severe arthritis within 72 hours. To evaluate the role of complement, SWR mice were bred with congenic inbred B10.D2/oSn (complement deficient) and B10.D2/nSn (complement normal) mice. Collagen-immunized (SWR x B10.D2/nSn)F1 mice had high levels of C5 and were susceptible to arthritis, while (SWR x B10.D2/oSn)F1 mice were deficient in C5 and were resistant to arthritis.
Reife
R A
RA
Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163.
Loutis
N
N
Watson
W C
WC
Hasty
K A
KA
Stuart
J M
JM
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000032:analysis*; D001168:Arthritis / Q000139:chemically induced / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D003182:Complement C5 / Q000032:analysis; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains
D000906:Antibodies; D003182:Complement C5; D003094:Collagen