The protective effect of hyperbaric oxygen on hearing during chronic noise exposure.
A series of experiments were conducted on guinea pigs to study the protective effect of hyperbaric oxygen (HBO) on hearing during chronic repeated noise exposure. A 1/3 octave band of noise centered at 1000 Hz was used (126 dB SPL, 1 h daily for 5 d; or 108 dB SPL, 1 h daily, 5 d/week for 4 weeks). Some groups of animals were treated with HBO (2-3 ATA, 1 h duration) before noise exposure. The results indicate that inhalation of HBO (every other day) can markedly reduce noise-induced threshold shift and relieve cochlear damage. The mechanism responsible for HBO protection against noise-induced hearing damage is discussed.
Hu
Z Y
ZY
Naval Medical Research Institute, Shanghai, People's Republic of China.
Shi
X F
XF
Liang
Z F
ZF
Tang
Z W
ZW
Jin
X Q
XQ
D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D006931:Hyperbaric Oxygenation; D008297:Male