title: Ototoxic potential of gentamicin in ponies.
abstract: Ototoxicosis was evaluated in 6 healthy ponies given 5 mg of gentamicin/kg of body weight, q 8 h, IM. Ponies 1, 2, and 3 were dosed for 7 days and ponies 4, 5, and 6 were dosed for 14 days. Serum peak and trough concentrations of gentamicin were measured by radioimmunoassay at regular intervals. Brain stem auditory-evoked responses were recorded every 5 days up to 60 days after the first dose to monitor auditory function. Although serum gentamicin concentrations were within or above the accepted clinical therapeutic range, loss of auditory function was not observed at the frequency range (1 to 4 kHz) tested. Serum chemical values remained within the accepted clinical range and no evidence of nephrotoxicosis was observed. Seemingly, gentamicin given IM to healthy ponies was safe and had minimal risk of side effects.
authors.affiliation: Department of Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849.
authors.forename: A C
authors.initials: AC
authors.lastname: Nostrandt
authors.forename: W M
authors.initials: WM
authors.lastname: Pedersoli
authors.forename: A E
authors.initials: AE
authors.lastname: Marshall
authors.forename: W R
authors.initials: WR
authors.lastname: Ravis
authors.forename: B T
authors.initials: BT
authors.lastname: Robertson
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D005839:Gentamicins / Q000009:adverse effects* / Q000097:blood; D006311:Hearing Disorders / Q000139:chemically induced / Q000662:veterinary*; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D007668:Kidney / Q000187:drug effects; D008297:Male
chemical_list: D005839:Gentamicins