title: Efficacy of nitroscanate against naturally acquired infection with Ancylostoma caninum, Dipylidium caninum, and Trichuris vulpis in dogs.
abstract: Eighteen dogs with naturally acquired helminth infections were used to evaluate the efficacy of nitroscanate against Ancylostoma caninum, Dipylidium caninum, and Trichuris vulpis. Approximately 15 minutes before treatment, the dogs were given 100 to 200 g of canned dog food. Ten dogs were treated with nitroscanate (50 mg/kg of body weight, PO), and 8 dogs were given placebo tablets PO. The dogs were euthanatized and necropsied 10 days after treatment and helminths were recovered from the small intestine and cecum. On the basis of the number of worms recovered from treated dogs vs the number recovered from control dogs, we determined the efficacy of nitroscanate to be 99.6% against A caninum, 99.8% against D caninum, and 0% against T vulpis.
authors.affiliation: Department of Veterinary Microbiology and Parasitology, Texas A&M University, College Station 77843.
authors.forename: T M
authors.initials: TM
authors.lastname: Craig
authors.forename: S H
authors.initials: SH
authors.lastname: Mercer
authors.forename: C G
authors.initials: CG
authors.lastname: Wade
authors.forename: R C
authors.initials: RC
authors.lastname: Lynn
mesh_terms: D000722:Ancylostoma / Q000187:drug effects / Q000302:isolation & purification; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy; D006374:Helminthiasis, Animal; D008297:Male; D010647:Phenyl Ethers / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013861:Thiocyanates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary; D014258:Trichuris / Q000187:drug effects / Q000302:isolation & purification; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D010647:Phenyl Ethers; D013861:Thiocyanates; C011042:nitroscanate