title: [Clinical significance of manganese superoxide dismutase in ovarian carcinoma].
abstract: A monoclonal antibody to manganese superoxide dismutase (Mn-SOD) was measured in patients with epithelial ovarian carcinomas. An enzyme-linked immunosorbent assay has been developed to detect serum Mn-SOD. With this assay, only 0.9% of the 207 healthy females tested had more than 130 ng per milliliter of serum Mn-SOD. In contrast, 37 of 62 patients (59.7%) with epithelial ovarian carcinomas showed high levels of Mn-SOD. The serum Mn-SOD increased according to the clinical stage and declined to reflect the effects of therapy. Compared with CA-125, Mn-SOD showed a less frequent false positive rate (10%) in benign gynecological diseases. The determination of Mn-SOD levels proved to be a clinically useful marker for monitoring the response to treatment and to early detection of the recurrence of epithelial ovarian carcinomas.
authors.affiliation: Department of Obstetrics and Gynecology, Asahikawa Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Kanemoto
authors.forename: H
authors.initials: H
authors.lastname: Domon
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
authors.forename: Y
authors.initials: Y
authors.lastname: Endoh
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase