Role of Na(+)-Ca2+ exchange system in the pathogenesis of myocardial ischemia-reperfusion damage.
Results from a systematic experiment on isolated perfused rat heart and isolated myocytes of adult rat showed that the mechanism of calcium influx during myocardial ischemia-reperfusion is due to the development of intracellular sodium overload during ischemic period; on reperfusion, the high intracellular Na+ content activated the reverse direction of Na(+)-Ca2+ exchange over myocardial sarcolemma (SL), thus a large quantity of extracellular Ca2+ fluxed over the SL to the intracellular space, forming a condition of intracellular Ca2+ overload, which leads to irreversible damage of the myocardium.
Li
Z P
ZP
Department of Pathophysiology, Beijing Medical University, PRC.
Tang
C S
CS
Su
J Y
JY
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008345:Manganese / Q000494:pharmacology; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D016277:Ventricular Function, Left / Q000187:drug effects
D008345:Manganese; D010042:Ouabain; D012964:Sodium; D002118:Calcium