title: Morphometric assessment of wound healing in rats treated with a protein-free haemodialysate.
abstract: Morphological changes during soft-tissue repair are prime indicators of the processes involved in wound healing. A method has been developed to quantify such changes and applied for assessing the healing of partial thickness dermatome wounds treated either with Solcoseryl jelly or the matching vehicle. After 4 days of treatment, the active-treated wounds had already reached the reparative phase, whereas the vehicle-treated wounds were still in the proliferative phase. Furthermore, wound re-epithelialization was significantly improved under active treatment (P less than 0.005).
authors.affiliation: Solco Basle Ltd, Department of Pharmacology, Birsfelden, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Isler
authors.forename: A
authors.initials: A
authors.lastname: Bauen
authors.forename: M
authors.initials: M
authors.lastname: Hubler
authors.forename: M
authors.initials: M
authors.lastname: Oberholzer
mesh_terms: D000183:Actihaemyl / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D005782:Gels; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; D000183:Actihaemyl