title: The protective effect of hyperbaric oxygen on hearing during chronic noise exposure.
abstract: A series of experiments were conducted on guinea pigs to study the protective effect of hyperbaric oxygen (HBO) on hearing during chronic repeated noise exposure. A 1/3 octave band of noise centered at 1000 Hz was used (126 dB SPL, 1 h daily for 5 d; or 108 dB SPL, 1 h daily, 5 d/week for 4 weeks). Some groups of animals were treated with HBO (2-3 ATA, 1 h duration) before noise exposure. The results indicate that inhalation of HBO (every other day) can markedly reduce noise-induced threshold shift and relieve cochlear damage. The mechanism responsible for HBO protection against noise-induced hearing damage is discussed.
authors.affiliation: Naval Medical Research Institute, Shanghai, People's Republic of China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Hu
authors.forename: X F
authors.initials: XF
authors.lastname: Shi
authors.forename: Z F
authors.initials: ZF
authors.lastname: Liang
authors.forename: Z W
authors.initials: ZW
authors.lastname: Tang
authors.forename: X Q
authors.initials: XQ
authors.lastname: Jin
mesh_terms: D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D006931:Hyperbaric Oxygenation; D008297:Male