Phantom experiment and calculation for in vivo 10boron analysis by prompt gamma ray spectroscopy.
In order to determine 10B concentrations in a tumour in vivo without injuring tissues, phantom experiments and calculations were carried out for boron neutron capture therapy. The experiment was based on prompt gamma ray spectroscopy and a single-crystal silicon-filtered neutron beam from a TRIGA-II reactor. Calibration curves to determine the 10B concentrations in the tumours were experimentally generated from known 10B values for simulated tumours with various volumes in a phantom. The 10B distributions in a tumour were also investigated and it was possible to distinguish the tumour with 10B from normal tissue without 10B. In addition, the 10B concentrations were estimated by calculations. A two-dimensional discrete ordinate transport code, DOT3.5, was employed for the calculations of the neutron fluence rate distributions in a phantom. The number of incidental gamma rays entering a germanium detector, which were produced in a tumour as a result of neutron reaction, were calculated by an analytical method. The results were in good agreement with the experiments.
Matsumoto
T
T
Atomic Energy Research Laboratory, Musashi Institute of Technology, Kawasaki-shi, Japan.
Aoki
M
M
Aizawa
O
O
D001895:Boron / Q000032:analysis* / Q000627:therapeutic use; D005720:Gamma Rays; D006801:Humans; D007554:Isotopes; D008953:Models, Anatomic; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods
D007554:Isotopes; D001895:Boron