[Optimal combined use of rifampicin and immunomodulator of microbial origin in experimental Q-Rickettsia infection].
Multifactorial analysis of the combined use of rifampicin and an immunomodulator of the microbial origin, such as peptidoglycan, was performed on a model of experimental Q fever in albino mice. On the basis of the experimental results, statistic polynomial models describing the weight of the murine spleens and the titers of the complement-binding antibodies were designed. It was shown that the action of the immunomodulator and antibiotic was highly synergistic with respect to the chemotherapeutic activity and antibody titers. The preventive use of the immunomodulator yielded a 30-fold decrease in a rifampicin therapeutic dose. The use of the immunomodulator also provided a pronounced immunomodulating effect with respect to humoral immunity. Nomographs for optimizing the dose-time parameters of the antibacterial and immunomodulating therapy were plotted.
Nikitin
A V
AV
Klimchuk
N D
ND
Fomina
I P
IP
Ivanitskaia
L P
LP
Rozdobud'ko
V N
VN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010457:Peptidoglycan / Q000008:administration & dosage*; D011778:Q Fever / Q000188:drug therapy* / Q000276:immunology; D012293:Rifampin / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D010457:Peptidoglycan; D012293:Rifampin
Optimizatsiia kombinirovannogo primeneniia rifampitsina s immuno- moduliatorom mikrobnogo proiskhozhdeniia pri éksperimental'nom Ku-Rikketsioznoĭ infektsii.