Evaluation of controlled release formulations: estimation of the duration of the zero-order absorption and ascertainment of absorption kinetics.
A compartmental approach for estimating the duration of the zero-order absorption was developed. For drugs obeying one-compartment model disposition, the estimation is based on an explicit relationship while an iterative process is required for drugs represented by two-compartment kinetics. A method based on a double graphical plot for ascertaining absorption kinetics for drugs exhibiting one-compartment model disposition was also developed.
Macheras
P
P
Department of Pharmacy, University of Athens, Greece.
D000042:Absorption; D003692:Delayed-Action Preparations; D008954:Models, Biological; D010599:Pharmacokinetics; D012044:Regression Analysis; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D013806:Theophylline