[Prediction of bone marrow function by the appearance rate of RNA-rich reticulocytes during the chemotherapy for hematologic malignancy].
Percentage of RNA-rich (High fluorescence Ratio, HFR), RNA-middle (Middle Fluorescence Ratio, MFR) and RNA-low (Low Fluorescence Ratio, LFR) reticulocytes was estimated by Sysmex R-1000 reticulocyte counter during the chemotherapy of 27 cases with acute leukemia and malignant lymphoma (36 courses). In the beginning of marrow suppression, HFR and/or MFR were decreased faster than LFR, neutrophils or platelets in 14 courses (38.9%). Simultaneous decrease of HFR, MFR and other blood cells were observed in 57.2%. In the recovery phase of bone marrow, faster increase of HFR and/or MFR was noted in 52.8% and simultaneous increase of these reticulocytes with other blood cells was observed in 9 courses (25%). Appearance rate of RNA-rich younger reticulocytes is a sensitive parameter for the prediction of bone marrow suppression and recovery during the chemotherapy for hematologic malignancy.
Muguruma
Y
Y
Department of Hematological Laboratory, Toranomon Hospital, Tokyo, Japan.
Nirasawa
M
M
Kurimoto
U
U
Tsukada
T
T
Ueyama
J
J
Miyakoshi
S
S
Morinaga
S
S
Mutoh
Y
Y
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000503:physiopathology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000378:metabolism*; D012156:Reticulocytes / Q000378:metabolism*
D012334:RNA, Neoplasm