[The action of tumor necrosis factor on the microvascular endothelium and its role in the morphological changes in the internal organs].
Tumor necrosis factor exerts the systemic influence on endothelial cells in vivo. Structural changes in endotheliocytes lead to specific damage in the organs. Interstitial and alveolar edema develops in lung. Kupffer cell activation, change of sinusoid endothelial cell porosity, lipid dystrophia of hepatocytes are revealed in liver, damage of glomerular and peritubular capillaries, dystrophic changes of tubular epithelial cells are found out in kidney. The data obtained indicate that endothelial cells in microvessels are one of major cellular targets for action of tumor necrosis factor.
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D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008168:Lung / Q000098:blood supply / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008833:Microcirculation / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha
Deĭstvie faktora nekroza opukholi na éndoteliĭ mikrososudov i rol' ego v morfologicheskikh izmeneniiakh vnutrennikh organov.