Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl) flavins.
A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.
Cowden
W B
WB
Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.
Halladay
P K
PK
Cunningham
R B
RB
Hunt
N H
NH
Clark
I A
IA
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical; D005415:Flavins / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013329:Structure-Activity Relationship
D000962:Antimalarials; D005415:Flavins