[Prophylactic sclerosis of esophageal varices. Results of a controlled prospective study].
BACKGROUND
Endoscopic sclerosis of esophageal varices is effective both to treat active hemorrhage and to prevent recurrences. By contrast, its usefulness for the prophylaxis of the first episode of hemorrhage is not well established, the available data being contradictory.


METHODS
Overall 46 patients with cirrhosis and esophageal varices of type B or higher, without previous upper gastrointestinal hemorrhage, were randomized to be treated with prophylactic sclerosis or not (n = 22 and 24, respectively). Both groups were comparable in age, sex, etiology of cirrhosis (mainly alcoholic), Child's degree of hepatic failure, coagulation studies, laboratory data and endoscopic findings.


RESULTS
In a mean follow up of 16 months, the patients treated with sclerosis had a higher frequency of hemorrhage from gastroesophageal varices (27%) than those in the control group (8%) (n.s.). However, this difference reached significance (p = 0.02) when only patients from Child's classes A and B were considered (31% in the sclerosis group vs 5% in the control group). The mortality rate was similar in both groups, with a probability of one year survival of 80 and 76% in the sclerosis and control groups, respectively.


CONCLUSIONS
The results indicate that prophylactic sclerotherapy does not improve short-term survival or reduce the risk of a first hemorrhage due to gastroesophageal varices of type B or higher in hepatic cirrhosis. It may even facilitate the development of this severe complication in Child's A and B class patients.
Quer
J C
JC
Servicio de Aparato Digestivo, Hospital Universitario de Badalona Germans Trias i Pujol, Badalona, Barcelona.
Boix
J
J
Planas
R
R
Domínguez
M
M
Abad-Lacruz
A
A
Humbert
P
P
Morillas
R
R
Guilera
M
M
Llovet
J M
JM
Gassull
M A
MA
D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000150:complications*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015911:Sclerotherapy / Q000009:adverse effects / Q000379:methods; D015996:Survival Rate
Esclerosis profiláctica de varices esofágicas. Resultados de un estudio prospectivo controlado.