title: [Replacement therapy of emphysema caused by alpha 1-antitrypsin deficiency].
abstract: The most common feature of alpha1-antitrypsin (alpha 1 AT) deficiency is pulmonary emphysema, which becomes manifest in the third to fifth life decades in most subjects with PiZZ phenotype. In recent years, replacement therapy with alpha 1 AT from the plasma of blood donors has been developed. We report the protocol of treatment which has begun to be used in our center, now including two patients. We discuss inclusion criteria, the treatment schedules, the adverse side-effects and the future outlook for this type of therapy.
authors.affiliation: Servicio de Neumologia, Hospital General Vall d'Hebron, Barcelona.
authors.forename: R
authors.initials: R
authors.lastname: Vidal
authors.forename: M
authors.initials: M
authors.lastname: Miravitlles
authors.forename: X
authors.initials: X
authors.lastname: de Gracia
authors.forename: B
authors.initials: B
authors.lastname: Gallego
authors.forename: F
authors.initials: F
authors.lastname: Morell
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011656:Pulmonary Emphysema / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000515:alpha 1-Antitrypsin / Q000008:administration & dosage* / Q000032:analysis; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: Tratamiento sustitutivo del enfisema por déficit de alfa1-antitripsina.