title: The kallikrein-kinin system in the colon and lung fluid from a cribriform degeneration (cri) mutant mouse.
abstract: The cribriform degeneration (cri) mutant mouse was widely studied in regard to the electrolyte and kallikrein metabolism because of its potentiality as a cystic fibrosis (CF) genetic animal model. In this paper the activity of the kallikrein-kinin system, and the kininase activity and glycoproteins concentration in colon and pulmonary lavage fluid (PLF) in homozygous mutant (cri/cri) and control sibling mice are described. The mutant mice showed a diminished kininogenase and kininase activity and glycoproteins concentrations in both studied organs. It is concluded that a kallikrein-kinin system alteration could be responsible of the cri/cri electrolyte defect.
authors.affiliation: Facultad de Farmacia y Bioquímica (Cátedra de Fisiología), Bs. Aires, Argentina.
authors.forename: O L
authors.initials: OL
authors.lastname: Catanzaro
authors.forename: A
authors.initials: A
authors.lastname: Zuccollo
authors.forename: S B
authors.initials: SB
authors.lastname: Vila
authors.forename: L
authors.initials: L
authors.lastname: Pullez
authors.forename: O H
authors.initials: OH
authors.lastname: Pivetta
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000201:enzymology*; D003106:Colon / Q000201:enzymology*; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000378:metabolism; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000378:metabolism*; D001121:Lysine Carboxypeptidase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains
chemical_list: D006023:Glycoproteins; D001121:Lysine Carboxypeptidase; D007610:Kallikreins