Physiologic levels of salivary epidermal growth factor stimulate migration of an oral epithelial cell line.
An established line of human oral epithelial cells exhibits chemotaxis to epidermal growth factor (EGF). The directed migration of these cells is time dependent with an approximate 10-fold increase in the number of cells responding to the chemoattractant by 6 h. Cell migration occurs in a concentration dependent manner with maximal response at approximately 1 ng/ml. This maximal chemotactic response occurs within the physiologic concentration range for EGF found in human saliva. These data suggest that EGF may be important for the maintenance of an intact oral epithelial (mucosal) barrier, and may play a vital role in oral mucosal wound healing.
Royce
L S
LS
Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
Baum
B J
BJ
D002465:Cell Movement / Q000187:drug effects*; D002633:Chemotaxis; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004847:Epithelial Cells; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D009061:Mouth Mucosa / Q000166:cytology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry*; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor