Detection of 3,6-dinitrobenzo[a]pyrene in airborne particulates.
3,6-Dinitrobenzo[a]pyrene, a new mutagen, was detected in airborne particulates collected in Santiago (Chile). The quantity of the compound in the airborne particulates was very small, accounting for 0.01 micrograms/g of total particulates (0.002 ng/m3 of air) at the lowest concentration. It was found that 3,6-dinitrobenzo[a]pyrene is readily decomposed by UV irradiation at 312 nm. The decomposed product was identified as 3-nitrobenzo[a]pyrene-6-quinone by means of mass spectrometry and proton nuclear magnetic resonance analysis. The mutagenicity of 3,6-dinitrobenzo[a]pyrene was 137,000 revertants/nmole for Salmonella typhimurium strain TA98, less than that for strain TA98/1,8-DNP6, an acetyltransferase-deficient mutant, and more than that for strain YG1024, an acetyltransferase-rich mutant.
Sera
N
N
Department of Health Science, Fukuoka Environmental Research Center, Japan.
Kai
M
M
Horikawa
K
K
Fukuhara
K
K
Miyata
N
N
Tokiwa
H
H
D000393:Air Pollutants / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000633:toxicity* / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
D000393:Air Pollutants; D009153:Mutagens; C068923:3,6-dinitrobenzopyrene; D001564:Benzo(a)pyrene