Calcium-regulating hormones in hypertension: vascular actions.
The vascular and potentially hypertensive actions of the calcium-regulating hormones 1,25-dihydroxychole-calciferol [1,25(OH)2D3], parathyroid hormone (PTH), and calcitonin and related factors such as parathyroid hypertensive factor (PHF) and calcitonin gene-related peptide (CGRP) are discussed. 1,25(OH)2D3 has inotropic and calciotropic actions on isolated vascular tissue whereas PTH is a vasodilator. PHF, which has been reported in plasma of humans with essential hypertension and spontaneously hypertensive rats, has both pressor and calciotropic actions. Calcitonin is without vascular effects and CGRP is a potent vasodilator. It is concluded that several of the hormones responsible for maintaining Ca2+ homeostasis modulate vascular Ca2+ metabolism and force generating capacity. These substances may be long-term modulators of vascular function and play a role in the determination of peripheral vascular resistance.
Bukoski
R D
RD
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Kremer
D
D
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002116:Calcitonin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D001685:Biological Factors; D010281:Parathyroid Hormone; C064505:parathyroid hypertensive factor; D002116:Calcitonin; D002117:Calcitriol; D015740:Calcitonin Gene-Related Peptide