Regulation of proximal reabsorption by effective arterial blood volume.
In summary, effective arterial volume is able to regulate the transport of NaCl, NaHCO3, and organic solutes in the proximal tubule. These effects are mediated by changes in renal hemodynamics that secondarily modify proximal tubular transport through changes in interstitial hydrostatic and oncotic pressure, changes in the levels of hormones such as angiotensin II, epinephrine, norepinephrine, dopamine, and atrial natriuretic factor, and changes in renal nerve activity. In addition, there are chronic effects of dietary NaCl, the mechanisms of which have yet to be determined.
Seldin
D W
DW
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9030.
Preisig
P A
PA
Alpern
R J
RJ
D000818:Animals; D001639:Bicarbonates / Q000493:pharmacokinetics; D001692:Biological Transport / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D006801:Humans; D007671:Kidney Concentrating Ability / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride / Q000493:pharmacokinetics; D014882:Water-Electrolyte Balance / Q000502:physiology
D001639:Bicarbonates; D012965:Sodium Chloride; D012964:Sodium