[Experimental study on the maintenance of sufficient hepatic circulation with arterial blood during the temporary occlusion of the hilar hepatic circulation].
This study was performed to clarify the lowest limit of the blood flow volume to maintain the normal energy metabolism in the liver of mongrel dogs under the condition of total hilar clamping when the hepatic circulation was supplied only through the extracorporeal catheter bypass from the artery to the hepatic portal vein in flow control. The proper hepatic artery was ligated. The levels of adenosine triphosphate and total adenine nucleotide in the liver tissue were maintained as in the same level as the pre-bypass value during 120 minutes of this procedure even though the rate of bypass flow varied between 25% to 100% of normal total hepatic blood flow. When the bypass flow decreased below 10% of the normal flow, the hepatic energy metabolism was observed broken and the anaerobic glycolysis progressed within 30 minutes. Regional hepatic blood flow measured by the hydrogen clearance method was decreased slightly in the 25%-bypass flow and extremely in the 10%-flow after 30 minutes of the bypass. The lowest limit of the arterial blood inflow volume to maintain the hepatic function was confirmed to be in the range between 10% and 25% of the normal total hepatic blood flow volume.
Sakata
T
T
First Department of Surgery, Okayama University Medical School, Japan.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001810:Blood Volume; D004285:Dogs; D004734:Energy Metabolism; D005112:Extracorporeal Circulation; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000502:physiology*; D011169:Portal Vein; D011773:Pyruvates / Q000378:metabolism
D000227:Adenine Nucleotides; D007773:Lactates; D011773:Pyruvates