[Reaction of the sympathetic-adrenal medulla system in young rats of different age to subcutaneous administration of a cardiotoxic dose of noradrenaline].
A quantitative histo-fluorescent investigation of the adrenal medulla and cardiac sympathetic nerves in young rats of various age has demonstrated a high degree in development of the adrenal medulla and a low density in arrangement of fluorescent nervous terminals in the ventricular myocardium in 3-week-old rats. During this period the animals show a low sensitivity to the catecholamine stress. At the age of 1.5 months the development of the sympatho-adrenomedullary system reaches the level specific for a mature animal; sensitivity to the norepinephrine stress increases noticeably, manifesting as a sharp activation of catecholamines secretion by the adrenal medulla and a high lethality.
Serov
R A
RA
Sokolova
N N
NN
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000320:Adrenergic Fibers / Q000187:drug effects* / Q000473:pathology; D000367:Age Factors; D000818:Animals; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006321:Heart / Q000187:drug effects / Q000294:innervation*; D007279:Injections, Subcutaneous; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D002395:Catecholamines; D009638:Norepinephrine
Reaktsiia simpato-adrenomedulliarnoĭ sistemy krysiat razlichnogo vozrasta na podkozhnoe vvedenie kardiotoksicheskoĭ dozy noradrenalina.