[Development of secondary immunodeficiency in acute pancreatitis].
Ligation of the pancreatic duct induces the development of the edematous form of acute pancreatitis (OFAP) which is characterized by sharp inhibition of the immune response to sheep erythrocytes. Contrykal injection intensifies development of the immune response in rats with OFAP and blocks the immunosuppressive activity of the serum protein high-molecular fraction. Injection of aminomethylbenzoic acid does not affect the development of the immune response in rats with OFAP and does not block the immunosuppressive activity of the high-molecular fraction of serum proteins. The difference in the immunomodulating effect of contykal and aminomethylbenzoic acid in OFAP correlates with the different effect of the agents on the activity of proteases and antiproteolytic proteins in blood serum.
Prokopenko
L G
LG
Bystrova
N A
NA
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D005260:Female; D007108:Immune Tolerance / Q000502:physiology*; D008297:Male; D010195:Pancreatitis / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
Razvitie vtorichnogo immunodefitsita pri ostrom pankreatite.