Effects of antibodies against octreotide in two patients with acromegaly.
Two patients developed specific IgG antibodies against octreotide after 2-3 years' treatment for acromegaly with this long acting somatostatin analogue. The presence of these antibodies reduced the plasma disappearance rate of total extractable octreotide by 60 and 80% respectively. When compared to that of non-immune acromegalic patients, the plasma half-life of octreotide in these two patients was 300 and 450 vs 110 min in those with no detectable octreotide antibodies. The sole observed consequence of the immunization was a marked prolongation of the interval of maximum GH inhibition from a mean of 5 to 8 and 10 h in the two patients described after octreotide injection.
Orskov
H
H
Medical Research Laboratories, University of Aarhus, Denmark.
Christensen
S E
SE
Weeke
J
J
Kaal
A
A
Harris
A G
AG
D000172:Acromegaly / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D013006:Growth Hormone / Q000097:blood; D006207:Half-Life; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000097:blood / Q000276:immunology* / Q000493:pharmacokinetics / Q000627:therapeutic use; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D013006:Growth Hormone; D015282:Octreotide