Inhibition of cholesterol absorption by neomycin, benzodiazepine derivatives and ketoconazole.
Neomycin and a benzodiazepine derivative (RO16-0521) inhibit similarly cholesterol absorption in man but the serum cholesterol level is reduced only by neomycin. Reason(s) for the difference are unknown. Ketoconazole inhibits 14 alpha-demethylation of lanosterol so that cholesterol synthesis is reduced. The agent inhibits also cholesterol absorption. The serum cholesterol level is reduced by about 20%, the lowering being potentiated by a simultaneous cholestyramine treatment.
Kesäniemi
Y A
YA
Department of Internal Medicine, University of Oulu, Finland.
Miettinen
T A
TA
D000924:Anticholesteremic Agents; D001569:Benzodiazepines / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D007408:Intestinal Absorption / Q000187:drug effects; D007654:Ketoconazole / Q000494:pharmacology*; D009355:Neomycin / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D001569:Benzodiazepines; C049434:Ro 16-0521; D002784:Cholesterol; D009355:Neomycin; D007654:Ketoconazole