[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis].
A correlation between changes of the hypothalamic mediator processes, hormone level in blood plasma, catecholamines and their catabolites in urine and changes of the activity of adenosine metabolism enzymes in the thymus and the spleen lymphocytes has been observed in C57B1 mice with Lewis lung carcinoma. Effect of leu- and met-enkephalines on neuroendocrine stress-realizing mechanisms proved to be different, that is responsible for their contrary effect on the metastatic growth--leu-enkephaline inhibits and met-enkephaline stimulates the process. It has been shown that an inhibitory effect of leu-enkephaline is greatly related to its stimulating influence on the thymus lymphocyte activity and a decrease of the functional activity of the spleen lymphocytes.
Nadiradze
Z O
ZO
Uamnskiĭ
V Iu
VIu
Shmal'ko
Iu P
IuP
Gachechiladze
A G
AG
D015720:5'-Nucleotidase / Q000187:drug effects* / Q000378:metabolism; D000243:Adenosine Deaminase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002277:Carcinoma / Q000201:enzymology* / Q000503:physiopathology / Q000601:surgery; D003214:Conditioning, Classical / Q000187:drug effects; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D007031:Hypothalamus / Q000503:physiopathology; D008175:Lung Neoplasms / Q000201:enzymology* / Q000503:physiopathology / Q000601:surgery; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013315:Stress, Psychological / Q000201:enzymology* / Q000503:physiopathology; D013950:Thymus Gland / Q000187:drug effects / Q000201:enzymology
D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase
Vliianie leĭ- i met-énkefalinov na aktivnost' adenozindezaminazy i 5'-nukleotidazy limfotsitov v usloviiakh stressornoĭ stimuliatsii metastazirovaniia.