[Coronary reserve determination by intracoronary papaverine: effects of various doses on coronary circulation and hemodynamics].
In 40 male coronary patients during heart catheterization the coronary flow reserve was investigated by continuous thermodilution in the coronary sinus after intracoronary papaverine application. Simultaneously a number of heart function parameters were recorded. Already the lowest dosage of papaverine (5 mg) was able to induce a maximal flow acceleration. Higher dosages were accompanied with haemodynamic side effects (increase of heart rate and left ventricular end-diastolic pressure, decrease of left ventricular systolic pressure, appearance of myocardial ischemia) without further increase of coronary flow. After at most 5 minutes time the papaverine effects completely disappeared. In conclusion, a safe, short-lasting and repeatable determination of the coronary flow reserve (for instance during PTCA) proved to be possible after intracoronary papaverine injection in low dosages (5 mg).
Franz
N
N
Klinik für Innere Medizin, Humboldt-Universität zu Berlin und Klinikum Berlin-Buch.
Modersohn
D
D
Romaniuk
P
P
Linss
G
G
D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D006328:Cardiac Catheterization; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D010208:Papaverine; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
D010208:Papaverine
Bestimmung der Koronarreserve durch intrakoronare Papaverinapplikation: Auswirkungen unterschiedlicher Dosen auf Koronarfluss and Hämodynamik.