Restricticin, a novel glycine-containing antifungal agent.
Restricticin (1) is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities and is unrelated to any previously known family of natural products. This unstable compound, as well as its corresponding N,N-dimethyl derivative (2), have been produced and isolated from both solid and liquid fermentations of Penicillium restrictum. The desglycyl hydrolysis product, restrictinol (3), was produced via the hydrolysis of pure restricticin and as an artifact of the isolation of restricticin.
Schwartz
R E
RE
Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
Dufresne
C
C
Flor
J E
JE
Kempf
A J
AJ
Wilson
K E
KE
Lam
T
T
Onishi
J
J
Milligan
J
J
Fromtling
R A
RA
Abruzzo
G K
GK
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004355:Drug Stability; D005285:Fermentation; D005998:Glycine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000032:analysis / Q000378:metabolism; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D011714:Pyrans; C069635:restricticin; D005998:Glycine