Modulation of specific immunity by ventral hippocampal formation in albino rats.
Rats with bilateral electrolytic ventral hippocampal formation (VHF) lesion show a significantly (p less than 0.001) enhanced migration of leucocytes in the presence of antigen. Immunization in these animals enhances (p less than 0.001) the leucocyte migration and presents a significant decrease in footpad thickness. Antibody titre (p less than 0.001) and plaque-forming cells (p less than 0.02) also show a significant decrease when compared with sham-lesion-immunized animals and control-immunized animals. These data indicate the influence of VHF in modulating the specific immunity.
Devi
R S
RS
Department of Physiology, Dr. A.L.M.PG. Institute of Basic Medical Sciences, University of Madras, Taramani, India.
Namasivayam
A
A
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D002465:Cell Movement; D006624:Hippocampus / Q000502:physiology*; D007109:Immunity; D007962:Leukocytes / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies