Unusual forms of insulin resistance.
Insulin resistance is an important feature in the pathogenesis of non-insulin-dependent diabetes mellitus. Some rare patients have syndromes associated with a severe form of insulin resistance, usually involving acanthosis nigricans and, in premenopausal females, hyperandrogenism. This review discusses two of the causes of insulin resistance: mutations in the insulin receptor gene and autoantibodies directed against the insulin receptor.
Taylor
S I
SI
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Accili
D
D
Cama
A
A
Imano
E
E
Kadowaki
H
H
Kadowaki
T
T
D000052:Acanthosis Nigricans / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics* / Q000276:immunology; D013577:Syndrome; D014770:Virilism / Q000209:etiology
D001786:Blood Glucose; D011972:Receptor, Insulin