Expression of a gene coding for breast tumor-associated antigen in thyroid papillary carcinoma.
The expression of the H23 gene, previously shown to be overexpressed in breast cancer tissue, was examined in various thyroid pathologies. Thyroid papillary carcinomas demonstrate significant H23 mRNA levels, whereas benign thyroid pathologies have very low levels of expression. H23 gene expression in thyroid cancer inversely correlated with that of thyroperoxidase and thyroglobulin genes. Immunoblot assays of thyroid cancer tissues revealed overexpression of H23 gene at the protein level as well The data presented indicate that dedifferentiation of thyroid tissue to the malignant state is associated with increased H23 gene expression and suppression of some thyroidal differentiation marker genes.
Weiss
M
M
Department of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Zaretsky
J
J
Zimlichman
R
R
Smorodinsky
N
N
Dion
A S
AS
Keydar
I
I
Wreschner
D H
DH
D000951:Antigens, Neoplasm / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D002291:Carcinoma, Papillary / Q000235:genetics*; D015870:Gene Expression; D015151:Immunoblotting; D007453:Iodide Peroxidase / Q000235:genetics; D018396:Mucin-1; D009077:Mucins; D012333:RNA, Messenger / Q000032:analysis; D013954:Thyroglobulin / Q000235:genetics; D013961:Thyroid Gland / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000235:genetics*
D000951:Antigens, Neoplasm; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D012333:RNA, Messenger; D013954:Thyroglobulin; D007453:Iodide Peroxidase