The Egr family of nuclear signal transducers.
Extracellular ligands regulate the induction of several genes without the need for de novo protein synthesis. A subset of these so-called immediate-early response genes (IEG) encode transcription factors. This report focuses on the Egr group of zinc finger transcription factors. Their characterization should provide important insights into how cells respond to diverse extracellular signals.
Sukhatme
V P
VP
Department of Medicine (Nephrology), Howard Hughes Medical Institute, Chicago, IL 60637.
D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D051766:Early Growth Response Protein 1; D006801:Humans; D017874:Immediate-Early Proteins; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D014157:Transcription Factors; D004247:DNA