title: [An analysis of hospital bacterial infections in cirrhotic patients undergoing selective intestinal decontamination].
abstract: Cirrhotic patients with ascites and low levels of ascitic fluid C3 and total protein and cirrhotic patients with gastrointestinal hemorrhage are at high risk of infection. Selective intestinal decontamination with oral norfloxacin is useful to decrease the incidence of infections in cirrhotic patients at high risk. This study analyzes hospital acquired bacterial infections in cirrhotic patients with ascites and low levels of total protein in ascitic fluid (n = 53) and cirrhotic patients with gastrointestinal hemorrhage (n = 26), both submitted to selective intestinal decontamination with norfloxacin during the hospitalization. Seven patients developed eight infections (8.8%): three patients with ascites and low levels of total protein in ascitic fluid and four patients with gastrointestinal hemorrhage (5.6% vs 15.3%, pNS). Gram negative bacilli were not isolated in any case, but Gram positive cocci were isolated in seven cases. These results suggest that Gram positive cocci must be empirically covered when infection is suspected in cirrhotic patients submitted to selective intestinal decontamination. The analysis of antibiograms in these infections showed a high sensitivity of Gram positive cocci to amoxycillin and clavulanic acid, which could be used as empirical treatment when infection is suspected in these patients.
authors.affiliation: Sección de Hepatología, Escuela de Patología Digestiva, Hospital de la Santa Creu i Sant Pau, Barcelona.
authors.forename: A
authors.initials: A
authors.lastname: Tomás
authors.forename: G
authors.initials: G
authors.lastname: Soriano
authors.forename: C
authors.initials: C
authors.lastname: Guarner
authors.forename: M
authors.initials: M
authors.lastname: Teixidó
authors.forename: C
authors.initials: C
authors.lastname: Méndez
authors.forename: F
authors.initials: F
authors.lastname: Tena
authors.forename: E
authors.initials: E
authors.lastname: Fábrega
authors.forename: C
authors.initials: C
authors.lastname: Villanueva
authors.forename: J
authors.initials: J
authors.lastname: Such
authors.forename: J
authors.initials: J
authors.lastname: Balanzó
mesh_terms: D001201:Ascites / Q000150:complications / Q000382:microbiology; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D003666:Decontamination / Q000379:methods*; D005260:Female; D006801:Humans; D015994:Incidence; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000382:microbiology; D008297:Male; D009643:Norfloxacin / Q000627:therapeutic use; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D009643:Norfloxacin
vernacular_title: Análisis de las infecciones bacterianas intrahospitalarias en pacientes cirróticos sometidos a descontaminación intestinal selectiva.