title: Phase II study of 13-cis-retinoic acid in pediatric patients with acute nonlymphocytic leukemia--a Pediatric Oncology Group study.
abstract: Forty-one patients with refractory acute non-lymphocytic leukemia (ANLL) in relapse were treated with 13-cis-retinoic acid (cRA) as salvage therapy. The cRA was given as a single oral dose of 100 mg/m2/day for 4 weeks. One patient achieved a complete remission and two patients achieved a partial remission with reduction of the bone marrow blast count from 40 to 20% after the first course. We recommend further study of cRA in combination with other agents in the treatment of ANLL in children.
authors.affiliation: Division of Pediatric Hematology/Oncology, Emory University, Atlanta, Georgia 30322.
authors.forename: B A
authors.initials: BA
authors.lastname: Bell
authors.forename: H W
authors.initials: HW
authors.lastname: Findley
authors.forename: J
authors.initials: J
authors.lastname: Krischer
authors.forename: V M
authors.initials: VM
authors.lastname: Whitehead
authors.forename: T
authors.initials: T
authors.lastname: Holbrook
authors.forename: M E
authors.initials: ME
authors.lastname: Haggard
authors.forename: P N
authors.initials: PN
authors.lastname: Konrad
authors.forename: M
authors.initials: M
authors.lastname: Hensley
authors.forename: A H
authors.initials: AH
authors.lastname: Ragab
mesh_terms: D000293:Adolescent; D002455:Cell Division; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000473:pathology; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology; D008297:Male; D012074:Remission Induction; D014407:Tumor Cells, Cultured
chemical_list: D015474:Isotretinoin