Histamine and its congener derivatives as immune modulators.
Our knowledge of the function of histamine as an immunoregulatory autacoid is expanding. The presence of histamine in many tissues in which the immune response takes place and its release during immune response lend credibility to the notion that histamine's role in the immune response could be an important one. In this report we present data that demonstrate the immune modulatory role of histamine. We also describe the synthesis and novel pharmacologic effects of congener derivatives of histamine. These new lymphocyte specific histamine H1 and/or H2 agonists make it feasible to assess the potential of histamine as a selective in vivo immune modulator.
Khan
M M
MM
Department of Medicine (Division of Clinical Pharmacology), Stanford University School of Medicine, CA.
Melmon
K L
KL
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006632:Histamine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007109:Immunity; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; D002118:Calcium