Suppression of delayed type hypersensitivity by desferoxamine.
Desferoxamine, a chelating agent, inhibits proliferation of T cells in vitro. We reasoned that it may also suppress T-cell-mediated immune responses in vivo. The effect of desferoxamine on delayed type hypersensitivity reaction to dinitrofluorobenzene was evaluated in Balb/c mice. We report that desferoxamine inhibits sensitization and elicitation of skin test reactivity and that the immunosuppressive effect of desferoxamine is transient. While its mechanism of action remains to be determined, it may be a potentially useful immunosuppressive agent.
Sahasrabudhe
D M
DM
Cancer Center, University of Rochester School of Medicine and Dentistry, New York.
Dusel
J
J
Jedlika
S
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002712:Chlorides; D003676:Deferoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D004139:Dinitrofluorobenzene / Q000276:immunology; D005290:Ferric Compounds / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D002712:Chlorides; D005290:Ferric Compounds; D004139:Dinitrofluorobenzene; D003676:Deferoxamine; C024555:ferric chloride