The nickel content of certain commercially available metallic patch test materials and its relevance in nickel-sensitive subjects.
The nickel contamination of the metallic patch test substances from 3 commercial sources was estimated by atomic absorption spectrophotometry. Contamination was generally greatest in the cobalt patch test substances. To determine whether the levels of contamination encountered were sufficient to produce a false positive patch test, 20 nickel-sensitive patients were patch tested to various concentrations of free elemental nickel in aqueous solution. The level of nickel contamination was less than that required to produce a false positive patch test in our patients, but was at a level which could produce false positive reactions in subjects highly sensitive to nickel.
Eedy
D J
DJ
Department of Dermatology, Royal Victoria Hospital, Belfast, UK.
Burrows
D
D
McMaster
D
D
D000293:Adolescent; D000328:Adult; D002857:Chromium; D003035:Cobalt; D003300:Copper; D003877:Dermatitis, Contact / Q000175:diagnosis*; D004340:Drug Contamination; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals / Q000008:administration & dosage; D008875:Middle Aged; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D010165:Palladium; D010328:Patch Tests; D013054:Spectrophotometry, Atomic
D008670:Metals; D002857:Chromium; D003035:Cobalt; D010165:Palladium; D003300:Copper; D009532:Nickel