Enhanced resection and improved survival in murine neuroblastoma (C1300-NB) after preoperative immunotherapy.
Advanced neuroblastoma treated with standard chemotherapy has a poor prognosis. Combination immunotherapy for murine neuroblastoma with retinyl palmitate, low-dose cyclophosphamide, and interleukin-2 resulted in increased survival, impaired tumor growth, easier surgical resection, and increased class I expression or tumor cells. Preoperative immunotherapy may be useful in treatment of advanced human neuroblastoma.
Fowler
C L
CL
Department of Surgery, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
Brooks
S P
SP
Squire
R
R
Rich
G A
GA
Rossman
J E
JE
Finegold
M J
MJ
Allen
J E
JE
Cooney
D R
DR
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004224:Diterpenes; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D007167:Immunotherapy; D007376:Interleukin-2 / Q000008:administration & dosage*; D051379:Mice; D008805:Mice, Inbred A; D009447:Neuroblastoma / Q000276:immunology / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D011300:Preoperative Care; D011994:Recombinant Proteins / Q000008:administration & dosage; D000084562:Retinyl Esters; D015996:Survival Rate; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives
D004224:Diterpenes; D015395:Histocompatibility Antigens Class I; D007376:Interleukin-2; D011994:Recombinant Proteins; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D003520:Cyclophosphamide