Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells.
The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid of women with intrauterine infections and preterm labor. Hence, interleukin-6 may contribute to the mechanism of preterm labor under these conditions.
Mitchell
M D
MD
Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City 84132.
Dudley
D J
DJ
Edwin
S S
SS
Schiller
S L
SL
D000650:Amnion / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D003656:Decidua / Q000187:drug effects / Q000378:metabolism*; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000494:pharmacology*; D010920:Placenta / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*
D015850:Interleukin-6; D011453:Prostaglandins; D015232:Dinoprostone