[Bone marrow transplantation in pediatrics: its current status, the problems and prospects].
Notwithstanding the high proportion that achieve a cure after chemotherapy, there are still a case in which only a BMT can offer a chance of cure. This minority of patients can undergo an allogeneic BMT if a HLA matched donor is available or an autologous BMT if a good remission is achieved before the BMT. Not all the patients comply with these criteria. Therefore we need to widen the availability of the donors searching for unrelated matched donors or facing the problems of an aplohidendical BMT. The efforts to treat even children with advanced disease are based on the possibility of overcoming the blasts resistance or of stimulating the non-HLA restricted cytotoxicity with IL2.
Agosti
E
E
Clinica Pediatrica, Università di Trieste.
Andolina
M
M
de Manzini
A
A
Mascarin
M
M
D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods / Q000639:trends*; D002648:Child; D006801:Humans; D014019:Tissue Donors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
Il trapianto di midollo osseo in pediatria: stato attuale, problemi e prospettive.