title: Interaction of prostaglandin E1 with alpha-cyclodextrin in aqueous systems: stability of the inclusion complex.
abstract: Prostavasin, an inclusion complex of prostaglandin E1 (PGE1) with alpha-cyclodextrin (alpha-CD), is used in the therapy of thrombosis. Nuclear magnetic resonance measurements have been made to study the interaction of PGE1 with alpha-CD. The observed interaction (chemical shift) and the derived dissociation constant prove that only weak interaction forces are operative and that complete dissociation occurs upon dilution.
authors.affiliation: Institute for Experimental Biology and Medicine, Borstel, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Wiese
authors.forename: H P
authors.initials: HP
authors.lastname: Cordes
authors.forename: H
authors.initials: H
authors.lastname: Chi
authors.forename: J K
authors.initials: JK
authors.lastname: Seydel
authors.forename: T
authors.initials: T
authors.lastname: Backensfeld
authors.forename: B W
authors.initials: BW
authors.lastname: Müller
mesh_terms: D000527:Alprostadil / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009994:Osmolar Concentration; D012996:Solutions; D013816:Thermodynamics; D047391:alpha-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D012996:Solutions; D047391:alpha-Cyclodextrins; D000527:Alprostadil; C032613:alpha-cyclodextrin