[Hypertension treated with isotetrandrine].
The antihypertensive effect of isotetrandrine (IT) has been studied, in 50 cases with hypertension with the cross-over experiment controlled with nitrendipine (NTP). The results of the study demonstrate that the antihypertensive efficacy of IT to the mild and moderate or phase I, II, III hypertension cases was definite. After ingestion of the single-dose 0.2 g of IT, BP fell at 30 min, the maximal fall in BP was observed at 4 h and duration of the action was sustained for 8 hours. After administration of daily dose 0.3-0.6 g of IT for 4 wk, the total response rate of all patients was 84%. Compared with NTP, the total response rate difference was not significant. During treatment, the heart rate was slightly decreased, the blood lipids and glucose were not influenced, the left ventricular functions were obviously improved, and the adverse effects were fewer and milder. The antihypertensive mechanism of it may be associated with the blocking calcium channel.
Dong
H Y
HY
Hospital of Guiyang Medical College.
Yao
C
C
D000328:Adult; D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects
D000470:Alkaloids; D000959:Antihypertensive Agents; D044182:Benzylisoquinolines; C009438:tetrandrine; D009568:Nitrendipine