[Clinical significance of manganese superoxide dismutase in ovarian carcinoma].
A monoclonal antibody to manganese superoxide dismutase (Mn-SOD) was measured in patients with epithelial ovarian carcinomas. An enzyme-linked immunosorbent assay has been developed to detect serum Mn-SOD. With this assay, only 0.9% of the 207 healthy females tested had more than 130 ng per milliliter of serum Mn-SOD. In contrast, 37 of 62 patients (59.7%) with epithelial ovarian carcinomas showed high levels of Mn-SOD. The serum Mn-SOD increased according to the clinical stage and declined to reflect the effects of therapy. Compared with CA-125, Mn-SOD showed a less frequent false positive rate (10%) in benign gynecological diseases. The determination of Mn-SOD levels proved to be a clinically useful marker for monitoring the response to treatment and to early detection of the recurrence of epithelial ovarian carcinomas.
Ishikawa
M
M
Department of Obstetrics and Gynecology, Asahikawa Medical College.
Hayashi
H
H
Saitoh
S
S
Shimizu
T
T
Yamashita
K
K
Saitoh
Y
Y
Kanemoto
T
T
Domon
H
H
Kamiya
H
H
Endoh
Y
Y
D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*
D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase