Environment, genetics and idiopathic Parkinson's disease.
Since Idiopathic Parkinson's disease (IPD) was first described more than 170 years ago, there have been major advances in the understanding of the etiology of the disease as well as in its treatment. This article will review current knowledge concerning the role of the environment, genetic hypotheses and the aging factor in the etiology of IPD and proposes a complex interaction involving all these factors. Hypotheses regarding mitochondrial inhibition and free radical generation in IPD are discussed in relation to the mechanism of action of neurotoxins known to produce parkinsonian syndromes.
Poirier
J
J
McGill Centre For Studies in Aging, Montreal, Québec, Canada.
Kogan
S
S
Gauthier
S
S
D000375:Aging; D001812:Blood-Brain Barrier; D004785:Environmental Pollutants / Q000009:adverse effects; D005609:Free Radicals; D006801:Humans; D008543:Melanins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009498:Neurotoxins; D010101:Oxygen Consumption; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000628:therapy
D004785:Environmental Pollutants; D005609:Free Radicals; D008543:Melanins; D009498:Neurotoxins; C014121:neuromelanin