Gastric acid secretion and parietal cell mass: effect of sex hormones.
The role of sex hormones on parietal cell function and number was studied in the rat. Ovariectomy significantly increased parietal cell mass (from 18.26 +/- 0.16 x 10(6) to 24.14 +/- 0.89 x 10(6] as well as basal acid secretion (from 3.49 +/- 0.06 to 3.63 +/- 0.05 mu Eq/10 min). Castration decreased the number of parietal cells in the gastric mucosa of male rats from 25.57 +/- 0.18 x 10(6) to 18.65 +/- 0.12 x 10(6) and basal acid secretion (from 3.99 +/- 0.03 to 3.50 +/- 0.06 mu Eq/10 min). The results suggest that male and female sex hormones regulate basal acid secretion via their effects on the parietal cell.
Adeniyi
K O
KO
Department of Human Physiology, Faculty of Medical Sciences, University of Jos, Nigeria.
D000818:Animals; D002452:Cell Count / Q000187:drug effects*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D008297:Male; D009919:Orchiectomy; D009929:Organ Size; D010052:Ovariectomy; D010295:Parietal Cells, Gastric / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000033:anatomy & histology
D012739:Gonadal Steroid Hormones