Low-protein, low-phosphorus diet and tissue insulin sensitivity in insulin-dependent diabetic patients with chronic renal failure.
Tissue insulin sensitivity was measured by the glucose clamp technique in 8 uremic insulin-dependent diabetic patients before and after 3 months on a low-protein diet (LPD) providing daily 35 kcal/kg body weight, 60% of the caloric supply being obtained from carbohydrates. An improvement in tissue insulin sensitivity was observed for each steady state of the clamp and daily insulin requirements decreased significantly from 38.3 +/- 3.2 to 28.2 +/- 2.5 units (p less than 0.01) in spite of an increased carbohydrate intake. It is suggested that LPD lowers the production and accumulation of uremic toxins interfering with insulin sensitivity.
Gin
H
H
Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin-Tripode, Bordeaux, France.
Aparicio
M
M
Potaux
L
L
Merville
P
P
Combe
C
C
de Precigout
V
V
Bouchet
J L
JL
Aubertin
J
J
D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy* / Q000188:drug therapy / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000178:diet therapy* / Q000503:physiopathology; D004044:Dietary Proteins / Q000008:administration & dosage*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000009:adverse effects* / Q000627:therapeutic use; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016226:Phosphorus, Dietary / Q000008:administration & dosage*
D004044:Dietary Proteins; D007328:Insulin; D016226:Phosphorus, Dietary