title: Halothane enhances the binding of diazepam to synaptic membranes from rat cerebral cortex.
abstract: The effects of halothane on diazepam binding to the rat cerebral synaptic membranes were investigated. Halothane at the concentrations of 0.63, 1.3 and 4.1 mmol/l increased the binding by 12, 23 and 33%, respectively, compared to the control in the absence of halothane. The increments were dependent on the presence of Cl-. The findings indicate that halothane and diazepam have an interaction at receptor level.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Murakawa
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D006221:Halothane / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013570:Synaptic Membranes / Q000378:metabolism*
chemical_list: D003975:Diazepam; D006221:Halothane