title: Computer assisted analysis of hand radiographs in infantile hypophosphatasia carriers.
abstract: Hand radiographs of 49 carriers of infantile hypophosphatasia and 67 non-carriers were evaluated using two Apple IIe Computer Programs and an Apple Graphics Tablet. CAMPS (1) was used to determine the bone lengths and calculate the metacarpophalangeal profiles. A newly developed program (ADAM) was used to determine bone density based on percent cortical area of the second metacarpal. Carriers of infantile hypophosphatasia had significantly less dense bones.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Canada.
authors.forename: B N
authors.initials: BN
authors.lastname: Chodirker
authors.forename: D
authors.initials: D
authors.lastname: Roy
authors.forename: C R
authors.initials: CR
authors.lastname: Greenberg
authors.forename: M
authors.initials: M
authors.lastname: Cheang
authors.forename: J A
authors.initials: JA
authors.lastname: Evans
authors.forename: M H
authors.initials: MH
authors.lastname: Reed
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D002648:Child; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging; D006580:Genetic Carrier Screening; D006801:Humans; D007014:Hypophosphatasia / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging*; D008838:Microcomputers; D008875:Middle Aged; D011859:Radiography; D012680:Sensitivity and Specificity