title: Induction and modulation of interleukin 1 production by defined partial structures of lipopolysaccharide.
abstract: Bacterial lipopolysaccharides (LPS) consist of a hydrophilic heteropolysaccharide component and a covalently linked hydrophobic lipid portion termed lipid A. Lipid A is responsible for most of the toxic and immunoregulatory effects of LPS. In studying the structure-function relationship of lipid A partial structures we now report that certain synthetic analogues, with themselves being biologically "inactive", exert immunomodulating effects on LPS-induced Interleukin 1 production in vitro.
authors.affiliation: Forschungsinstitut Borstel, Germany.
authors.forename: H D
authors.initials: HD
authors.lastname: Flad
authors.forename: W
authors.initials: W
authors.lastname: Feist
authors.forename: M H
authors.initials: MH
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Brade
authors.forename: E T
authors.initials: ET
authors.lastname: Rietschel
authors.forename: A J
authors.initials: AJ
authors.lastname: Ulmer
mesh_terms: D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D006017:Glycolipids / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood*; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology
chemical_list: D006017:Glycolipids; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; C044283:lipid X