[Captopril and hydrochlorothiazide for the treatment of arterial hypertension in the elderly].
A clinical trial was performed to assess the association of captopril-hydrochlorotiazide in a large population of hypertensive outpatients divided into two groups: elderly subjects and control group of adults. The hypotensive effect was evaluated and statistical differences between basal values after some months of treatment were highly significant. Together with results, variations in blood as a result of lower pressure are reported, whereas renal functions, and the glucose and electrolytic metabolism remained constant. The characteristics of the pharmacological compound, which may be used to treat any degrees of arterial hypertension, are discussed together with its utility in geriatric patients and the pharmacological synergy between the ACE-inhibitor and the diuretic agent.
Tamburrini
L R
LR
Cattedra di Geriatria, Università degli Studi di Trieste.
Di Monte
M
M
D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006403:Hematologic Tests; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D006852:Hydrochlorothiazide; D002216:Captopril
Captopril e idroclorotiazide nel trattamento dell'ipertensione arteriosa dell'anziano.