Studies of the susceptibility of Pneumocystis carinii to clindamycin/primaquine in rats.
Studies in rat models showed that the combination of primaquine plus clindamycin was effective in the therapy and prophylaxis of Pneumocystis carinii pneumonia and that the combination was more effective than either drug alone. These studies formed the basis of ongoing clinical therapy studies and provide a basis for clinical studies of prophylactic efficacy.
Smith
J W
JW
Department of Pathology, Indiana University School of Medicine, Indianapolis 46202-5250.
D000818:Animals; D002981:Clindamycin / Q000494:pharmacology*; D007108:Immune Tolerance; D008826:Microbial Sensitivity Tests; D011010:Pneumocystis / Q000187:drug effects* / Q000254:growth & development; D011319:Primaquine / Q000494:pharmacology*; D051381:Rats
D002981:Clindamycin; D011319:Primaquine