title: [Induction chemotherapy with cisplatin and 5-FU in locally advanced head and neck cancer. Study of 2 administration schedules].
abstract: 67 patients were included in two different protocols with cisplatin and 5-fluorouracil as induction chemotherapy. Group A (30 patients), received cisplatin in bolus and 5-FU in continuous infusion for 120 hours, and Group B (37 patients), were treated with cisplatin and 5-FU both in continuous infusion for 96 hours. All patients received surgery and/or radiotherapy after chemotherapy. Overall response in Group A was 73% with 27% Complete Clinic Response (CCR), and in Group B 81% with 40.5% (CCR). Overall survival at 24 months was 58% and 63%, respectively.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Clínico Universitario de Salamanca.
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: J J
authors.initials: JJ
authors.lastname: Cruz
authors.forename: J L
authors.initials: JL
authors.lastname: Pardal
authors.forename: A
authors.initials: A
authors.lastname: Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Fonseca
authors.forename: A G
authors.initials: AG
authors.lastname: Bernal
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: A
authors.initials: A
authors.lastname: Cañizo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Quimioterapia de inducción con cisplatino y 5-FU en cáncer de cabeza y cuello localmente avanzado. Estudio en dos protocolos de administración.