The effect of preoperative flurbiprofen on miosis produced by acetylcholine during cataract surgery.
Sustained pupillary dilation during cataract surgery may be achieved with preoperative noncorticosteroidal anti-inflammatory agents such as flurbiprofen. However, these agents may interfere with miosis after injection of acetylcholine. Thirty patients for extracapsular cataract extraction were randomly assigned in a double-masked fashion to receive either a placebo or preoperative 0.03% flurbiprofen every 30 minutes for four doses. All patients also received three doses of 2.5% phenylephrine and 2% cyclopentolate. Pupillary diameter was measured the day before surgery, immediately before the surgical incision, immediately before and five minutes after acetylcholine injection, and the morning after surgery. The flurbiprofen group had a larger mean pupillary diameter before injection of acetylcholine (P less than .001), five minutes after acetylcholine (P less than .001), and on the first postoperative day (P less than .005).
Holmes
J M
JM
Department of Ophthalmology, Loyola University Medical Center, Maywood, Illinois 60153.
Jay
W M
WM
D000109:Acetylcholine / Q000494:pharmacology*; D000287:Administration, Topical; D000368:Aged; D002387:Cataract Extraction; D004311:Double-Blind Method; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015877:Miosis; D011184:Postoperative Period; D011300:Preoperative Care; D011680:Pupil / Q000187:drug effects
D005480:Flurbiprofen; D000109:Acetylcholine