Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties.
In this study, eight new 1-(2-benzoxazolinone-6-yl)-2-(4-arylpiperazine-1-yl)ethanol and -propanol derivatives have been prepared. Their structures have been elucidated by IR- and 1H-NMR-spectra and by elementary analysis. The analgesic activities of these compounds, using modified Koster's test have been investigated. 1-(5-Chloro-3-methyl-2-benzoxazolone-6-yl)-2-[4-(2-methoxyphenyl)p iperazine-1- yl]ethanol has been found more active than O-acetyl-salicylic acid, respectively.
Erdogan
H
H
University of Hacettepe, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Debaert
M
M
Cazin
J C
JC
D000433:1-Propanol / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000431:Ethanol / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009135:Muscular Diseases / Q000139:chemically induced / Q000503:physiopathology; D010084:Oxidation-Reduction; D010147:Pain Measurement; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D001583:Benzoxazoles; D010879:Piperazines; D000431:Ethanol; D000433:1-Propanol; D001241:Aspirin