title: [Neonatal blood group incompatibility due to anti-M antibodies].
abstract: Neonatal blood group antagonism due to anti-M antibodies is extremely rare. The case is reported of a neonate with moderately severe haemolytic anaemia due to anti-M which required two blood transfusions. Although anti-M antibodies are as a rule regarded as clinically irrelevant, and although they react almost exclusively at lower temperatures, they may in exceptional cases be demonstrated at 37 degrees C, as in the patient described; they may then cause haemolysis. Most strikingly, the direct Coombs test in this patient was negative; this phenomenon has been described before. In unexplained haemolytic anaemia of a newborn, even in the presence of a negative direct Coombs test, the possibility of blood group antagonism should be considered.
authors.affiliation: Algemeen Klinisch Laboratorium, afd. Bloedtransfusie, Catharina Ziekenhuis, Eindhoven.
authors.forename: J J
authors.initials: JJ
authors.lastname: Hoffmann
authors.forename: A P
authors.initials: AP
authors.lastname: Hutter
authors.forename: A A
authors.initials: AA
authors.lastname: Loomans
authors.forename: A G
authors.initials: AG
authors.lastname: Tielens
mesh_terms: D000745:Anemia, Hemolytic, Congenital / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D001787:Blood Group Incompatibility / Q000150:complications* / Q000276:immunology; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000302:isolation & purification*; D008951:MNSs Blood-Group System / Q000276:immunology*; D008297:Male
chemical_list: D007518:Isoantibodies; D008951:MNSs Blood-Group System
vernacular_title: Neonataal bloedgroepantagonisme door anti-M-antistoffen.