Variables predicting oral mucosal lesions in allogenic bone marrow recipients.
One hundred and forty-eight (72%) of 205 allogenic bone marrow transplant recipients developed mucosal lesions in the oral cavity during the aplastic period after transplantation. Lesions were most frequent 8 to 9 days after transplantation. Factors that correlated with the development of mucosal lesions after univariate and multivariate analysis were a marrow cell dose of less than 3 x 10(8) cells/kg body weight, (p less than 0.0001), prolonged aplastic period (white blood cell count less than 0.2 x 10(9) cell/l during more than 14 days (p less than 0.005), herpes simplex virus-1 seropositivity of the recipient (p less than 0.01), and conditioning with total body irradiation (p less than 0.02).
Mattsson
T
T
Department of Oral Surgery, Karolinska Institute, Huddinge, Sweden.
Heimdahl
A
A
Dahllof
G
G
Nilsson
B
B
Lonnqvist
B
B
Ringdén
O
O
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000741:Anemia, Aplastic / Q000150:complications; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000517:prevention & control; D015999:Multivariate Analysis; D011336:Probability; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors; D014916:Whole-Body Irradiation
D003524:Cyclosporins; D003520:Cyclophosphamide; D008727:Methotrexate