Breast feeding modifies production of SIgA cow's milk-antibodies in infants.
One hundred and fifty-eight healthy mature newborns were divided into 3 groups according to their risk of allergy: Group A, no risk (n = 62), group B, low risk (n = 30) and Group C, high risk (n = 66). Saliva was collected at birth and after 3 and 6 months. SIgA anti-casein and anti-beta-lactoglobulin were determined by a direct ELISA technique. The highest concentrations of secretory antibodies were measured after birth. After 3 months, breast fed infants had lower salivary SIgA anti-casein concentrations than the group receiving cow's milk (p less than 0.01). The effect of breast-feeding was seen even after a nursing period of only 3 weeks. Infants without risk of allergy fed cow's milk exclusively had higher SIgA anti-casein (p less than 0.03) and anti-beta-lactoglobulin concentrations than low risk infants at the age of 6 months. These data show a modifying effect of breast feeding on salivary SIgA production against cow's milk protein.
Renz
H
H
Children's Hospital, Marburg, Germany.
Brehler
C
C
Petzoldt
S
S
Prinz
H
H
Rieger
C H
CH
D000818:Animals; D001942:Breast Feeding; D002364:Caseins / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D007782:Lactoglobulins / Q000276:immunology; D008297:Male; D008892:Milk / Q000276:immunology*; D008895:Milk, Human / Q000276:immunology*; D012463:Saliva / Q000276:immunology*
D002364:Caseins; D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M; D007782:Lactoglobulins; C033027:secretory IgM