title: Does chylomicronemia cause atherosclerosis?
abstract: Does chylomicronemia cause atherosclerosis? To directly address this clinically important problem, we conducted experiments in guinea pigs which lack apolipoprotein CII and develop chylomicronemia when they are fed a high-fat diet. After 6-12 months on a high-fat diet, guinea pigs were sacrificed, and subjected to histopathological and ultrastructural examination. Both the aorta and the coronary arteries revealed no atherosclerotic changes in all 4 animals examined: the endothelium was intact, and neither lipid-laden foam cells nor migrating cells were present within the arterial wall. Our studies indicate that chylomicronemia does not predispose to atherosclerosis.
authors.affiliation: Department of Endocrinology and Metabolism, Okinaka Memorial Institute for Medical Research, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Murase
authors.forename: M
authors.initials: M
authors.lastname: Okubo
authors.forename: M
authors.initials: M
authors.lastname: Hara
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002914:Chylomicrons / Q000097:blood*; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008074:Lipoproteins / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D002914:Chylomicrons; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides