Morphometric assessment of wound healing in rats treated with a protein-free haemodialysate.
Morphological changes during soft-tissue repair are prime indicators of the processes involved in wound healing. A method has been developed to quantify such changes and applied for assessing the healing of partial thickness dermatome wounds treated either with Solcoseryl jelly or the matching vehicle. After 4 days of treatment, the active-treated wounds had already reached the reparative phase, whereas the vehicle-treated wounds were still in the proliferative phase. Furthermore, wound re-epithelialization was significantly improved under active treatment (P less than 0.005).
Isler
H
H
Solco Basle Ltd, Department of Pharmacology, Birsfelden, Switzerland.
Bauen
A
A
Hubler
M
M
Oberholzer
M
M
D000183:Actihaemyl / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D005782:Gels; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects*
D005782:Gels; D000183:Actihaemyl