title: Inner ear damage secondary to diabetes mellitus. I. Changes in adolescent SHR/N-cp rats.
abstract: The association between diabetes mellitus and hearing impairment has been debated in many previous studies. The spontaneous hypertensive/NIH-corpulent (SHR/N-cp) rat has been shown to be a unique genetic model for non-insulin-dependent diabetes mellitus. Seventeen diabetic and 17 control young male rats were divided into groups according to diet and phenotype. The rats were fed either 54% of sucrose or 54% starch diets for 3.5 months and killed at 5 months. The cochleas were fixed, decalcified, dissected, and stained for hair cell counting. A significant loss of outer hair cells was noted in the diabetic obese (SHR/N-cp) animals when compared with the control obese (LA/N-cp) animals in every group. Although no significant difference was noted between the diabetic obese (SHR/N-cp) animals receiving the starch and sugar diets, the diabetic obese (SHR/N-cp) animals were more severely affected than the nondiabetic lean (SHR/N-cp) rats.
authors.affiliation: Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill.
authors.forename: R J
authors.initials: RJ
authors.lastname: Triana
authors.forename: G W
authors.initials: GW
authors.lastname: Suits
authors.forename: S
authors.initials: S
authors.lastname: Garrison
authors.forename: J
authors.initials: J
authors.lastname: Prazma
authors.forename: P B
authors.initials: PB
authors.lastname: Brechtelsbauer
authors.forename: O E
authors.initials: OE
authors.lastname: Michaelis
authors.forename: H C
authors.initials: HC
authors.lastname: Pillsbury
mesh_terms: D000818:Animals; D003051:Cochlea / Q000648:ultrastructure; D015834:Cochlear Diseases / Q000209:etiology* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006311:Hearing Disorders / Q000209:etiology* / Q000473:pathology; D008297:Male; D009765:Obesity / Q000150:complications; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013213:Starch / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage
chemical_list: D004040:Dietary Carbohydrates; D013395:Sucrose; D013213:Starch