Preliminary evidence for bacterial endotoxin therapeutics of paraquat lethality in mice.
In mice treated with endotoxin (LPS) extracted from Escherichia coli (1 mg/kg, i.p.), 3 hr after paraquat (70 mg/kg, i.p.) a delay in the appearance of deaths and a decrease in their number in 10-day cumulative mortality were observed in comparison to those injected with saline after paraquat.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D004731:Endotoxins / Q000627:therapeutic use*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010269:Paraquat / Q000633:toxicity*
D004731:Endotoxins; C044101:endotoxin, Escherichia coli; D010269:Paraquat