Effects of the oral administration of glycosaminoglycans on cellular abnormalities associated with idiopathic calcium oxalate nephrolithiasis.
Oral administration of mixture of extractive glycosaminoglycans to a group of renal stone formers led to a significant decrease in oxalate self-exchange and in erythrocytes membrane protein phosphorylation traits that are abnormal in the majority of patients with idiopathic calcium nephrolithiasis. The action of glycosaminoglycans at the cellular level is probably due to their modulating activity on certain membrane protein kinases. The proven effect of the glycosaminoglycans opens a new pharmacological approach to the prevention of recurrent nephrolithiasis.
Baggio
B
B
Institute of Internal Medicine, University of Padova, Italy.
Gambaro
G
G
Marzaro
G
G
Marchini
F
F
Borsatti
A
A
Crepaldi
G
G
D000284:Administration, Oral; D000328:Adult; D002129:Calcium Oxalate / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D010766:Phosphorylation
D006025:Glycosaminoglycans; D000960:Hypolipidemic Agents; D008565:Membrane Proteins; D002129:Calcium Oxalate; C007858:glucuronyl glucosamine glycan sulfate