title: Comparison of cotton wool swab and cytobrush for detection of chlamydial infection in women attending a genitourinary medicine clinic.
abstract: Endocervical specimens obtained by cytobrush and conventional cotton wool swabs from 90 women attending a genitourinary medicine clinic were compared for their efficiency in detecting chlamydial infection. Isolation of Chlamydia trachomatis and detection of the chlamydial lipopolysaccharide antigen were attempted on each specimen. Antigen was detected in 18% of cytobrush and 17% of swab specimens. The cytobrush proved less suitable than swabs for isolation because 8 cytobrush specimens (9%) were toxic to the McCoy cells. Toxicity was significantly associated with an infected endocervix (2P = 0.004). Cytobrush therefore appeared to have little advantage over the much cheaper alternative, the cotton wool swab.
authors.affiliation: Department of Genitourinary Medicine, Manchester Royal Infirmary, UK.
authors.forename: D
authors.initials: D
authors.lastname: Mandal
authors.forename: T K
authors.initials: TK
authors.lastname: Ray
authors.forename: S J
authors.initials: SJ
authors.lastname: Richmond
authors.forename: B P
authors.initials: BP
authors.lastname: Goorney
authors.forename: K R
authors.initials: KR
authors.lastname: Haye
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis; D002690:Chlamydia Infections / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D002692:Chlamydia trachomatis; D004739:England / Q000453:epidemiology; D005188:False Negative Reactions; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D010044:Outpatient Clinics, Hospital; D012680:Sensitivity and Specificity; D014626:Vaginal Smears / Q000295:instrumentation* / Q000379:methods
chemical_list: D000942:Antigens, Bacterial