title: Effect of a terpenoid, (-)-6-hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol, on drug-metabolizing enzymes and glutathione content in rat liver and lung.
abstract: 1. Chronic treatment of Sprague-Dawley rats with the new terpenoid mucoregulating drug (I) did not modify activities of the drug-metabolizing enzymes (phase I and phase II) of liver and lung. 2. Acute treatment of rats with I did not affect the GSH content of liver and lung, but administration of the corresponding alpha, beta-unsaturated ketone (II) produced considerable GSH depletion in both tissues, the original GSH levels being restored after a few hours. 3. The results are discussed in comparison with those previously obtained with the structurally related drug trans-sobrerol (III).
authors.affiliation: Istituto di Mutagenesi e Differenziamento, C.N.R., Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lippi
authors.forename: P G
authors.initials: PG
authors.lastname: Gervasi
authors.forename: G
authors.initials: G
authors.lastname: Bellucci
authors.forename: F
authors.initials: F
authors.lastname: Marioni
authors.forename: F
authors.initials: F
authors.lastname: Luzzani
authors.forename: P
authors.initials: P
authors.lastname: Ventura
mesh_terms: D000818:Animals; D003511:Cyclohexanols / Q000494:pharmacology*; D053138:Cyclohexenes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D007659:Ketones / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology
chemical_list: D003511:Cyclohexanols; D053138:Cyclohexenes; D007659:Ketones; D004364:Pharmaceutical Preparations; D013729:Terpenes; C065237:6-hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol; D003577:Cytochrome P-450 Enzyme System; C003316:sobrerol; D010088:Oxidoreductases; D005978:Glutathione