title: Progression to AIDS among Italian HIV-seropositive haemophiliacs. Italian Group.
abstract: To investigate the interval between HIV-1 infection and the development of clinical AIDS among Italian patients with congenital coagulation disorders, a national cohort study was undertaken in 1988. Information was collected both retrospectively and prospectively on 499 HIV-1-positive patients enrolled in an ongoing national registry of patients with congenital coagulation disorders. Two methods were used to estimate each patient's seroconversion date: the mid-point between the last negative (either known or estimated) and the first positive test, and the median under a Weibull distribution, which was assumed to fit seroconversion data. The two methods of estimating the seroconversion time yielded similar results. The actuarial incidence of AIDS was estimated using the Kaplan-Meier survival analysis at 12.8% (95% confidence interval = 9.7-15.9) over 7 years for Italian haemophiliacs. Progression appears to be slow in the first 5 years after the infection, and to rise steadily thereafter. A strong association between faster progression and older age at seroconversion was found. Zidovudine-treated individuals seem to have a slower progression than untreated individuals, after controlling for CD4, but there was no association between progression and type and severity of the congenital disorder.
authors.affiliation: National AIDS Operational Centre, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Schinaia
authors.forename: A
authors.initials: A
authors.lastname: Ghirardini
authors.forename: F
authors.initials: F
authors.lastname: Chiarotti
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology / Q000401:mortality; D015497:HIV-1 / Q000276:immunology; D006467:Hemophilia A / Q000150:complications* / Q000401:mortality; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D016019:Survival Analysis; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D015215:Zidovudine