[Use of heparin in the prevention of thrombotic complications in aged oncologic patients].
A method for the prevention of thrombotic complications with heparin was developed during examination of 30 elderly and old-aged patients who underwent operation for gastric carcinoma. It was established that the therapeutic activity of heparin in plasma is maintained for 6 hours after a single subcutaneous injection of 5,000 u. Four injections of this dose of heparin ensures its continuous therapeutic activity for 24 hours in elderly oncological patients. Heparin prevention in a daily dose of 20,000 u is safe from the standpoint of hemorrhagic complications. Under clinical conditions, control of plasma heparin activity may be accomplished by means of activated partial thromboplastin time.
Riabov
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Pasechnik
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D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006493:Heparin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011183:Postoperative Complications / Q000517:prevention & control; D013274:Stomach Neoplasms / Q000097:blood / Q000601:surgery*; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors
D006493:Heparin
Primenenie geparina v profilaktike tromboticheskikh oslozhneniĭ u onkologicheskikh bol'nykh pozhilogo vozrasta.