title: Synthesis and antifungal properties of 3-bromo-4,5,6,7-tetrahydro-1,2-benzoisoxazole derivatives.
abstract: The synthesis of 3-bromo-4,5,6,7-tetrahydro-1,2-benzoisoxazole derivatives and their activity against human pathogen fungi are reported. In particular, compound 3,5-dibromo-6,7-dihydro-1,2-benzoisoxazol-4-(5H)-one showed a broad antifungal spectrum and good fungicidal activity against Trichophyton mentagrophytes.
authors.affiliation: Laboratori di Ricerca Zambon Group, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Napoletano
authors.forename: D
authors.initials: D
authors.lastname: Chiarino
authors.forename: A
authors.initials: A
authors.lastname: Sala
authors.forename: E
authors.initials: E
authors.lastname: Albini
authors.forename: C
authors.initials: C
authors.lastname: Pinasi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D007555:Isoxazoles; D009153:Mutagens; C069447:3,5-dibromo-6,7-dihydro-1,2-benzisoxazol-4-(5H)-one