Bacille Calmette-Guérin--associated neonatal hepatitis.
We describe a full-term immunocompetent neonate who developed jaundice at 3 weeks of age. Physical examination disclosed no abnormalities. Laboratory investigations showed direct reacting hyperbilirubinaemia and elevated liver enzymes. Liver biopsy revealed a non-caseating granulomatous hepatitis. The patient made an uneventful recovery within 4 weeks without therapy. Bacille Calmette-Guérin hypersensitivity reaction is suggested as the reason for this neonatal hepatitis.
Simma
B
B
Department of Paediatrics, Innsbruck University Hospital, Austria.
Dietze
O
O
Vogel
W
W
Ellemunter
H
H
Guggenbichler
J P
JP
D001500:BCG Vaccine / Q000009:adverse effects*; D001706:Biopsy; D005500:Follow-Up Studies; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology; D008099:Liver / Q000473:pathology; D008297:Male; D014611:Vaccination / Q000009:adverse effects*
D001500:BCG Vaccine