title: Influence of UV irradiation on the composition of human stratum corneum lipids.
abstract: Irradiation with suberythemal doses of either UV-A or UV-B yielded an increase in the amount of stratum corneum lipids extracted from the lumbar skin area of 20 volunteers. These lipids were quantified after separation by high-performance thin-layer chromatography. Ten subfractions in the ceramide region were separated; two of them (fractions 7a and 7b) were only detectable after UV-A or UV-B irradiation. Improvement of barrier function after UV irradiation of human skin with suberythemal doses may be related to an increase in the stratum corneum ceramides.
authors.affiliation: Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wefers
authors.forename: B C
authors.initials: BC
authors.lastname: Melnik
authors.forename: M
authors.initials: M
authors.lastname: Flür
authors.forename: C
authors.initials: C
authors.lastname: Bluhm
authors.forename: P
authors.initials: P
authors.lastname: Lehmann
authors.forename: G
authors.initials: G
authors.lastname: Plewig
mesh_terms: D000328:Adult; D002518:Ceramides / Q000528:radiation effects; D002855:Chromatography, Thin Layer; D004817:Epidermis / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays
chemical_list: D002518:Ceramides; D008055:Lipids