title: [Effect of inclusion complexation of decanoic acid with alpha-cyclodextrin on rectal absorption of cefmetazole sodium suppository in rabbits].
abstract: Inclusion complex of decanoic acid (DA) with alpha-cyclodextrin (alpha-CyD) was prepared as an additive of cefmetazole sodium (CMZ) suppository and rectally administered to rabbits. The resulting complexation was examined by the phase solubility method, differential scanning calorimetry (DSC) and X-ray diffractometry. Plasma concentration and AUC of CMZ after rectal administration of a suppository containing DA/alpha-CyD complex to rabbits increased more significantly than those with none additive.
authors.affiliation: Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yanagi
authors.forename: N
authors.initials: N
authors.lastname: Ishikura
authors.forename: H
authors.initials: H
authors.lastname: Kenmotsu
authors.forename: N
authors.initials: N
authors.lastname: Yagi
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Sumiya
authors.forename: M
authors.initials: M
authors.lastname: Takada
mesh_terms: D000277:Adjuvants, Pharmaceutic; D000818:Animals; D015311:Cefmetazole / Q000493:pharmacokinetics*; D003505:Cyclodextrins / Q000494:pharmacology*; D003652:Decanoic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D007408:Intestinal Absorption / Q000187:drug effects*; D011817:Rabbits; D012007:Rectum / Q000378:metabolism*; D013268:Stimulation, Chemical; D013488:Suppositories; D047391:alpha-Cyclodextrins
chemical_list: D000277:Adjuvants, Pharmaceutic; D003505:Cyclodextrins; D003652:Decanoic Acids; D004338:Drug Combinations; D013488:Suppositories; D047391:alpha-Cyclodextrins; D015311:Cefmetazole; C031071:decanoic acid; C032613:alpha-cyclodextrin