Dimethly sulphoxide lowers ICP after closed head trauma.
Ten patients with closed head trauma and elevated intracranial pressure (ICP) ranging from 40-127 mm Hg were treated with intravenous dimethyl sulphoxide (DMSO) every 6 h for 1-10 days. Four patients received DMSO and intermittent oxygen. All patients showed a reduction of ICP after 24 h and 7 had normal ICP after 6 days of treatment. Two patients died of their injuries. Neurological assessment at the time of discharge showed 2 patients with severe neurological deficits and 6 patients with mild to no deficit. After a 3 month follow-up, 1 patient remained severely impaired and 7 patients showed mild to no deficit. It appears that intravenous DMSO can rapidly reduce elevated ICP in severe closed-head injury and that it improves neurological outcome.
Karaca
M
M
Division of Neurological Surgery, University of Dicle, Turkey.
Bilgin
U Y
UY
Akar
M
M
de la Torre
J C
JC
D006259:Craniocerebral Trauma / Q000503:physiopathology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D014949:Wounds, Nonpenetrating / Q000503:physiopathology*
D004121:Dimethyl Sulfoxide