Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins.
The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross-linking variable parts of the T cell receptor (TcR) with MHC class II molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non-stimulatory. However, the same T cell can respond to the same toxin on another AC and the same AC can present the same toxin to another T cell. This indicates that in the complex formed between TcR, toxin and class II molecule an interaction between TcR and class II molecule takes place.
Fleischer
B
B
Department of Medicine, University of Mainz, FRG.
Mittrücker
H W
HW
D000938:Antigen-Presenting Cells / Q000502:physiology*; D001427:Bacterial Toxins / Q000494:pharmacology*; D000949:Histocompatibility Antigens Class II / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
D001427:Bacterial Toxins; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell