[Protection of hematopoiesis in single and fractionated irradiation under the conditions of exogenous hypoxia].
The paper is concerned with some experimental data of a comparative study of the efficacy of a hypoxic mixture used for the protection of hemopoietic tissue in single and fractionated irradiation of animals. The protective effect was shown to be on the decrease in change from acute to fractionated irradiation during hypoxia. The use of two criteria of assessment (specific for the hemopoietic system--CFU-C and integral--50% the survival rate among animals 50%) confirmed the general direction of processes. Hypoxia used as a protector, resulted in a decrease in an effective irradiation dose, manifested in lesser affection of the hemopoietic stem cell pool and consequently in the proliferating bone marrow cell pool.
Zubenkova
E S
ES
Kazymbetov
P
P
Zaĭtsev
A V
AV
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis / Q000528:radiation effects*; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D000860:Hypoxia; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011835:Radiation Protection
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