Morphology and pathogenesis of endocrine hyperplasias, precarcinoid lesions, and carcinoids arising in chronic atrophic gastritis.
The spectrum of endocrine cell changes occurring in 80 cases of body-fundus chronic atrophic gastritis (CAG), mostly type A or multifocal, including various types of hyperplasia, precarcinoid lesions (20 cases), and neoplasia (carcinoid, 24 cases) have been analyzed histologically, histochemically, and ultrastructurally. Changes associated with gland atrophy, pyloric- or intestinal-type metaplasia, regenerative hyperplasia, and hypergastrinemia have been identified and their neoplastic potential evaluated in the light of their proliferative capacity (bromodeoxyuridine incorporation) and clinicopathologic behavior. A close link between disseminated precarcinoid lesions of non-tumor mucosa and multiple carcinoids (carcinoidosis) arising in hypergastrinemic type-A CAG is suggested. Hyperplastic changes, including endocrine cell clusters, seem to have no or only minimal neoplastic potential.
Solcia
E
E
Dept. of Human Pathology, Ist Medical Faculty, University of Pavia, Italy.
Fiocca
R
R
Villani
L
L
Gianatti
A
A
Cornaggia
M
M
Chiaravalli
A
A
Curzio
M
M
Capella
C
C
D002276:Carcinoid Tumor / Q000209:etiology / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000032:analysis; D004759:Enterochromaffin Cells / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology*
D006063:Chorionic Gonadotropin