Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice.
1. Diltiazem, verapamil and nifedipine produced a dose-dependent analgesic response in mice. 2. A fixed oral dose of acetylsalicylic acid increased this analgesic response. 3. Analgesia was maintained when mice were treated chronically with calcium channel blockers alone or when combined with aspirin.
al-Humayyd
M S
MS
Department of Medical Pharmacology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
D000700:Analgesics; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D016227:Benzoquinones; D004110:Diltiazem / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D011930:Reaction Time / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D000700:Analgesics; D016227:Benzoquinones; C029322:phenylbenzoquinone; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D001241:Aspirin