title: Defects in neutrophils: an overview.
abstract: Neutrophils are the host's first line of defense against many pathogenic bacteria and fungi. Disorders of neutrophil function are often suggested by recurrent cutaneous, periodontal, respiratory, or soft tissue infections. In this review, we summarize the current understanding of neutrophil function, provide an update of recent developments in the field, and outline an approach to diagnosis and management of the major congenital disorders of neutrophils.
authors.affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
authors.forename: T C
authors.initials: TC
authors.lastname: Sim
authors.forename: A S
authors.initials: AS
authors.lastname: Goldman
mesh_terms: D002452:Cell Count; D006801:Humans; D009503:Neutropenia / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D010585:Phagocyte Bactericidal Dysfunction / Q000628:therapy