title: Models for evaluating compounds for activity against Pneumocystis carinii.
abstract: Cultures and animal models have been developed to provide reproducible and uniform systems for evaluation of compounds for effects on Pneumocystis carinii. The culture model allows rapid low-cost screening of drugs for activity against trophozoite forms. The animal models allow testing of efficacy for prophylaxis and therapy of Pneumocystis carinii pneumonia.
authors.affiliation: Department of Pathology, Indiana University School of Medicine, Indianapolis 46202-5250.
authors.forename: M S
authors.initials: MS
authors.lastname: Bartlett
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D008168:Lung / Q000382:microbiology; D011010:Pneumocystis / Q000187:drug effects* / Q000254:growth & development; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains