title: Antiphospholipid antibodies in the aetiology of ischaemic optic neuropathy.
abstract: The involvement of antiphospholipid antibodies in the mediation of acute anterior ischaemic optic neuropathy (AION) was studied, in the light of recent associations between these autoantibodies and other vascular events. A strong association between IgG anticardiolipin antibodies and AION secondary to biopsy proven giant cell arteritis was identified, which did not exist with the 'non-arteritic', biopsy negative form of AION. The possible implications of this finding on the aetiology, diagnosis, and treatment of giant cell arteritis are discussed.
authors.affiliation: Royal Hallamshire Hospital, Sheffield.
authors.forename: M T
authors.initials: MT
authors.lastname: Watts
authors.forename: M
authors.initials: M
authors.lastname: Greaves
authors.forename: I G
authors.initials: IG
authors.lastname: Rennie
authors.forename: L G
authors.initials: LG
authors.lastname: Clearkin
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007511:Ischemia / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply*; D009901:Optic Nerve Diseases / Q000209:etiology / Q000276:immunology*; D010743:Phospholipids / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D002308:Cardiolipins; D007074:Immunoglobulin G; D010743:Phospholipids