title: [Changes in three-dimensional structure of the internal elastic membrane of rat aorta after its mechanical injury and regeneration].
abstract: By means of scanning electron microscopy of chemically extracted preparations the dynamics of changes in the three-dimensional structure of the internal elastic membrane (IEM) of the rat aorta has been investigated after its lesion by a vascular clip. The mechanical lesion results in rupture of the IEM along external borders of the instrument lips and in crushing of its central part. A niche is formed, along its periphery it is surrounded with a practically intact IEM. The aorta regeneration is accompanied with neoelastogenesis. In the center of the niche newly formed elastic structures appear later, but the IEM reparation develops more actively. During the neoelastogenesis some stages are distinguished: at first separate elastic fibers appear, which then anastomosed, uniting into fasciculi and laminae. It is supposed that the IEM-restoration at regeneration depends on synthetic activity of smooth myocytes and on the other hand, the changes in the IEM structure can regulate their migration and metabolism.
authors.forename: M D
authors.initials: MD
authors.lastname: Rekhter
authors.forename: O A
authors.initials: OA
authors.lastname: Bauman
authors.forename: A A
authors.initials: AA
authors.lastname: Mironov
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries / Q000503:physiopathology / Q000648:ultrastructure; D001019:Aortic Rupture / Q000473:pathology* / Q000503:physiopathology; D003250:Constriction; D004547:Elastic Tissue / Q000293:injuries* / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000502:physiology
vernacular_title: Izmeneniia trekhmernoĭ struktury vnutrenneĭ élasticheskoĭ membrany aorty krysy pri mekhanicheskom povrezhdenii i regeneratsii.