title: Cellular uptake of copper by hepatocytes.
abstract: Selective accumulation of copper in isolated hepatocytes compared to fibroblasts is due in part to decreased copper efflux, perhaps the result of the presence of high-affinity intracellular copper-binding proteins. Preferential accumulation of copper by the liver may serve to protect extrahepatic tissues from copper toxicity.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003300:Copper / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D008099:Liver / Q000378:metabolism*
chemical_list: D003300:Copper