The influence of gender on the susceptibility to multiple sclerosis in sibships.
A population-based study of pairs of relatives (siblings, second- and third-degree) concordant for multiple sclerosis did not show an excess of like-sexed pairs. In addition, data on human lymphocyte antigen typing for sibling pairs concordant for multiple sclerosis did not find an increase in haplotype sharing for like-sexed pairs. These data do not support the notion that sex-related factors influence multiple-sclerosis susceptibility in families.
Sadovnick
A D
AD
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Bulman
D E
DE
Hashimoto
L
L
D'Hooghe
M B
MB
Ebers
G C
GC
D004198:Disease Susceptibility; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D012723:Sex