Halothane-induced alteration in the fluidity of rat brain synaptosomal membranes and its relationship to anesthesia.
Concentrations of halothane 1.43% or higher abolished the pain response and induced anesthesia. Halothane increased membrane fluidity of synaptosomes and microsomes both at non-anesthetic and anesthetic concentrations. Changes in fluidity in synaptosomes did not return to control levels even after the animals recovered from anesthesia. Alteration in membrane fluidity by halothane is a non-selective effect and may not play a definitive role in anesthesia.
Sastry
B V
BV
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6600.
Franks
J J
JJ
Surber
M J
MJ
D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D006221:Halothane / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008861:Microsomes / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013574:Synaptosomes / Q000187:drug effects / Q000502:physiology*
D006221:Halothane