Ketamine enantiomers and acetylcholinesterase.
(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
Puu
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National Defence Research Establishment, Division of Experimental Medicine, Umeå, Sweden.
Koch
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Artursson
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D000110:Acetylcholinesterase / Q000378:metabolism; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D006868:Hydrolysis; D007649:Ketamine / Q000494:pharmacology*; D007700:Kinetics; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010766:Phosphorylation; D013237:Stereoisomerism
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D007649:Ketamine; D000110:Acetylcholinesterase