The effect of the novel antidepressant tianeptine on the concentration of 5-hydroxytryptamine in rat hippocampal dialysates in vivo.
Tianeptine is a novel tricyclic antidepressant which, in marked contrast to other antidepressants, increases the uptake of 5-HT in brain tissue and blood platelet preparations ex vivo. In the present study it was shown, by microdialysis, that tianeptine (10 mg/kg i.p.), whether given as a single dose or as daily doses for 14 days, attenuated the K(+)-evoked rise of extracellular 5-HT in the hippocampus in vivo. Tianeptine (10 mg/kg i.p.), given acutely, did not reduce basal levels of 5-HT in hippocampal dialysates in the presence of the 5-HT reuptake inhibitor, citalopram. These results suggest mutually opposing effects of tianeptine and citalopram on neuronal uptake of 5-HT. Their significance in relation to the role of 5-HT in the action of antidepressants is discussed.
Whitton
P S
PS
Department of Neurochemistry, Institute of Neurology, London, U.K.
Sarna
G S
GS
O'Connell
M T
MT
Curzon
G
G
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D004334:Drug Administration Schedule; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013841:Thiazepines / Q000008:administration & dosage / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D012701:Serotonin; D011188:Potassium