[Lung maturation during artificial placentation and mechanical lung distension].
An new method of lung maturation during artificial placentation was evaluated during a series of 15 animal experiments in premature lambs (gestational age 125-132 days). Perfusion circuit with interposition of a membrane lung was connected with the umbilical vessels. Extracorporeal CO2-removal (ECCO2-R) and apneic oxygenation were provided during lung distension. The ultramicroscopic pattern approved a maturation of the lung during the procedure showing development of lamellar bodies and surfactant secretion into the alveolar space. The biochemical analysis of the tracheal fluid showed a significant increase of both PC and PG concentrations (3.225 +/- 1.112 mg/100g to 24.228 +/- 3.36 mg/100 g respectively 0.249 +/- 0.11 mg/100 g of 0.622 +/- 0.09 mg/100 g. The biophysical function of the lung was also improved as was shown by a significant increase of the statistical compliance. We conclude that artificial placentation and lung distension might be a new mode of prophylaxis for respiratory distress syndrome in critically immature babies.
Schmidt
S
S
Universitäts-Frauenklinik Bonn.
Westphal
S
S
Decleer
W
W
Dudenhausen
J W
JW
Herbst
R
R
Schmitz
C
C
Krebs
D
D
Saling
E
E
D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005325:Fetal Organ Maturity; D008168:Lung / Q000196:embryology* / Q000648:ultrastructure; D010712:Phosphatidic Acids / Q000032:analysis; D010929:Placentation; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000378:metabolism; D012756:Sheep; D014132:Trachea / Q000378:metabolism
D010712:Phosphatidic Acids; D011663:Pulmonary Surfactants
Lungenreifung während künstlicher Plazentation und mechanischer Lungenblähung.