[Effect of proper-myl on humoral interactions between activated lymphocytes and neutrophils in patients with myeloproliferative diseases].
The lymphokine synthesizing function of peripheral blood lymphocytes (PBL) was studied in 22 patients with chronic myeloid leukemia (CML), 28 patients with subleukemic myelosis (SLM) and 15 healthy persons. The index of the neutrophil stimulation (INS) in CML (1.73 +/- 0.068) and SLM (1.458 +/- 0.004) was statistically significantly lower than that in the healthy persons (2.6 +/- 0.07). The use of proper-myl in the complex therapy markedly increased the ability of PBL to produce the factor stimulating phagocytic activity of neutrophils (INS 1.94 +/- 0.04 and 1.832 +/- 0.092). On the basis of the findings it was recommended to use proper-myl for prevention and treatment of infectious complications.
Guseva
S A
SA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy*; D008214:Lymphocytes / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology*; D055728:Primary Myelofibrosis / Q000276:immunology / Q000628:therapy*; D015002:Yeast, Dried / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D001688:Biological Products; D004338:Drug Combinations; D008222:Lymphokines; C003221:proper-myl
Vliianie proper-mila na kharakter gumoral'nogo vzaimodeĭstviia aktivirovannykh limfotsitov i neĭtrofilov krovi u bol'nykh mieloproliferativnymi zabolevaniiami.