Epidemiological and pathological studies of a familial thymic lymphosarcoma in bovine species.
A total of 216 cases of the thymic form of bovine leukosis were observed in Holstein calves in several departments of France over a period of 18 months. Almost all of these calves were sired by the same bull. The calves were negative for bovine leukemia virus-specific antibodies. Morphological studies, including light and electron microscopic cytology, and immunophenotyping were performed in 38 cases. The tumor cells exhibit membrane markers (T-cell antigens) at variable levels, which indicate that they are T-lymphoid derived. The cells are maintained at a very early stage of differentiation as indicated by TdT enzyme activity and the presence of MHC class II antigen.
Da Costa
B
B
Laboratoire d'Anatomie Pathologique-INRA, Ecole Nationale Vétérinaire, Alfort, France.
Djilali
S
S
Kessler
J L
JL
Sacré
B
B
Femenia
F
F
Parodi
A L
AL
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D005260:Female; D005602:France / Q000453:epidemiology; D016131:Lymphocyte Subsets / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013953:Thymus Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*
D004254:DNA Nucleotidyltransferases