Different behavioral deficits are induced by anoxia/hypoxia in neonatal and senescent rats: blockade by MK-801.
Rats exposed on their first postnatal day to 100% nitrogen for 25 min developed hyperactivity and lower performance in passive avoidance task during development. Administration of MK-801 (0.5 mg/kg i.p.) 1 h before anoxia or (0.25 and 0.5 mg/kg) 1 h after completely reversed this behavioral impairment. Senescent rats (24-26 months) exposed to hypoxia (92% N2 + 8% O2) for 5 h failed in their performance in C.A.R., 30 days later. Pretreatment with MK-801 (1 mg/kg i.p.) completely reversed this impairment. These data suggest that activation of endogenous NMDA receptors produces different behavioral consequences in neonatal and senescent rats and that MK-801 administration close to exposure of animals to anoxia or hypoxia can prevent such damage, thus preventing behavioral impairments in postnatal as well as in senescent rats.
Speiser
Z
Z
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.
Uziel
J
J
Defrin-Assa
R
R
Gitter
S
S
Urca
G
G
D000375:Aging / Q000523:psychology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D000860:Hypoxia / Q000523:psychology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D016291:Dizocilpine Maleate