[Neonatal blood group incompatibility due to anti-M antibodies].
Neonatal blood group antagonism due to anti-M antibodies is extremely rare. The case is reported of a neonate with moderately severe haemolytic anaemia due to anti-M which required two blood transfusions. Although anti-M antibodies are as a rule regarded as clinically irrelevant, and although they react almost exclusively at lower temperatures, they may in exceptional cases be demonstrated at 37 degrees C, as in the patient described; they may then cause haemolysis. Most strikingly, the direct Coombs test in this patient was negative; this phenomenon has been described before. In unexplained haemolytic anaemia of a newborn, even in the presence of a negative direct Coombs test, the possibility of blood group antagonism should be considered.
Hoffmann
J J
JJ
Algemeen Klinisch Laboratorium, afd. Bloedtransfusie, Catharina Ziekenhuis, Eindhoven.
Hutter
A P
AP
Loomans
A A
AA
Tielens
A G
AG
D000745:Anemia, Hemolytic, Congenital / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D001787:Blood Group Incompatibility / Q000150:complications* / Q000276:immunology; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000302:isolation & purification*; D008951:MNSs Blood-Group System / Q000276:immunology*; D008297:Male
D007518:Isoantibodies; D008951:MNSs Blood-Group System
Neonataal bloedgroepantagonisme door anti-M-antistoffen.