Breath-by-breath measurement of oxygen consumption and FIO2-FEO2 with increased oxygen demand.
Continuous on-line breath-by-breath measurement of pulmonary gas exchange was used to monitor the increase in oxygen uptake (VO2) and carbon dioxide excretion (VCO2) induced by the oxidative phosphorylation uncoupling agent 2, 4-dinitrophenol (DNP) in 10 dogs. With incremental doses of DNP totaling 5 mg/kg, the continuously monitored VO2 increased within 2-3 min after the first injection of the drug. VCO2 showed a similar response 4-6 min after the first injection. Temperature increase due to the pharmacological oxidative phosphorylation uncoupling required 20-30 min for a discernible change at this dose. This study also demonstrated a modified and compromised response to the drug in dogs where oxygen delivery was limited by mechanical ventilation.
Davies
R E
RE
Department of Anesthesia, Sinai Hospital, Detroit, Michigan.
Noe
F E
FE
Whitty
A J
AJ
Busby
M G
MG
Davies
K R
KR
D000818:Animals; D003201:Computers; D004140:Dinitrophenols / Q000494:pharmacology*; D004285:Dogs; D008991:Monitoring, Physiologic / Q000379:methods*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*
D004140:Dinitrophenols