Residual effects of lormetazepam on mood and performance in healthy elderly volunteers.
45 subjects aged over 65 years were randomly assigned to treatment with lormetazepam 0.5 mg or 1 mg or placebo. Mood and performance were measured with a battery of computerized tests. Subjects were tested before and after 1 and 8 nights of treatment. Pre- and post-treatment scores were analysed by a multivariate covariance technique, the pre-treatment score serving as covariate. The single and repeated doses of lormetazepam resulted in impairment of performance in a memory task, and the repeated dose administration impaired performance of a perceptual task. The single administration of a low dose gave an improvement in fine motor control. No change was found in the mood states of the subjects.
Deijen
J B
JB
Department of Psychology, Free University, Amsterdam, The Netherlands.
Heemstra
M L
ML
Orlebeke
J F
JF
D000339:Affect / Q000187:drug effects*; D000368:Aged; D000375:Aging / Q000502:physiology*; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003071:Cognition / Q000187:drug effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; C023842:lormetazepam; D008140:Lorazepam