title: Down-regulation of a kinase defective PKC-alpha.
abstract: A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.
authors.affiliation: Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Pears
authors.forename: P J
authors.initials: PJ
authors.lastname: Parker
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D015536:Down-Regulation; D007668:Kidney; D007700:Kinetics; D009154:Mutation; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate