title: Development of an acellular pertussis vaccine and its administration as a booster in healthy adults.
abstract: An acellular pertussis vaccine which contains highly purified pertussis toxoid (PT) and filamentous haemagglutinin (FHA) has been developed. These proteins have been shown to be stable, with essentially no significant reversion of the pertussis toxoid after a new detoxification procedure. Two clinical trials using this vaccine as a booster in 45 healthy adults have been performed. Results show that the vaccine was well tolerated, causing essentially mild, transient symptoms after administration. It induced an increase in anti-PT and anti-FHA antibody titres in all vaccinees.
authors.affiliation: University of Turku, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Ruuskanen
authors.forename: A
authors.initials: A
authors.lastname: Noel
authors.forename: A
authors.initials: A
authors.lastname: Putto-Laurila
authors.forename: J
authors.initials: J
authors.lastname: Pêtre
authors.forename: C
authors.initials: C
authors.lastname: Capiau
authors.forename: A
authors.initials: A
authors.lastname: Delem
authors.forename: D
authors.initials: D
authors.lastname: Vandevoorde
authors.forename: E
authors.initials: E
authors.lastname: Simoen
authors.forename: D E
authors.initials: DE
authors.lastname: Teuwen
authors.forename: H
authors.initials: H
authors.lastname: Bogaerts
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D005260:Female; D006388:Hemagglutinins / Q000008:administration & dosage / Q000302:isolation & purification; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000302:isolation & purification*; D014121:Toxoids / Q000008:administration & dosage / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D014121:Toxoids; C051093:pertussis toxoid