title: [Alinidine in multi-vessel coronary disease: reduction of stress-induced ischemic reaction].
abstract: Ten patients suffering from an angiographically documented coronary two- or three-vessel disease were examined to evaluate the effects of the specific bradycardiac agent alinidine during a bicycle stress test. Hemodynamic and electrocardiographic parameters were compared before and after an intravenous application of 30 mg of the substance. The alinidine plasma levels 30 min after the injection were 160.6 +/- 22.5 ng/ml) (mean +/- SEM). Alinidine significantly (p less than 0.05) reduced the resting levels of heart rate (8.5%), double product (10.3%), myocardial oxygen consumption (9.1%), and cardiac output (9.0%). During exercise, significantly less ST-segment depression (p less than 0.001) in the EKG was observed after alinidine application in nine out of 10 patients, and the rise of pulmonary artery pressure was significantly reduced (34.7 vs 38.1 mm Hg, mean p less than 0.05). However, alinidine had no effect on the maximum heart rate at the end of exercise. We, therefore, assume that the substance has additional anti-ischemic properties.
authors.affiliation: Abt. Kardiologie, Kerckhoff-Klinik, Bad Nauheim.
authors.forename: H
authors.initials: H
authors.lastname: Ditter
authors.forename: K D
authors.initials: KD
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Bahavar
authors.forename: M
authors.initials: M
authors.lastname: Schlepper
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects*; D005080:Exercise Test / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000889:Anti-Arrhythmia Agents; C022192:alinidine; D003000:Clonidine
vernacular_title: Alinidine bei koronarer Mehrgefässerkrankung: Reduktion der belastungsinduzierten Ischämiereaktion.