Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)-nitrosamine administration.
Combination effects of sequential treatment with uracil prior to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) with regard to carcinogenesis in the urinary bladder and renal pelvis were investigated in male F344 rats. Uracil was administered for 15, 10 or 5 weeks followed by BBN for 23 weeks, the total observation time being 40 weeks. Carcinoma(s) and papilloma(s) were induced in the urinary tract by the 15-week uracil treatment independent of subsequent BBN administration. It was concluded that uracil administration prior to BBN treatment is not associated with any synergistic effects, although both uracil and BBN alone exerted carcinogenicity.
Okumura
M
M
First Department of Pathology, Nagoya City University Medical School, Japan.
Shirai
T
T
Asamoto
M
M
Ogiso
T
T
Fukushima
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002085:Butylhydroxybutylnitrosamine / Q000008:administration & dosage / Q000633:toxicity*; D003043:Cocarcinogenesis; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007682:Kidney Pelvis / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010212:Papilloma / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D014498:Uracil / Q000008:administration & dosage / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002085:Butylhydroxybutylnitrosamine; D014498:Uracil