Factors controlling immunoglobulin production and B cell proliferation.
The proliferation and the differentiation of B lymphocytes is under the control of T cell and macrophage produced cytokines which drive resting B cells to the state of antibody-producing plasma cells. Antibodies exert a feedback control of their own production via their interaction with Fc receptor (FcR) bearing cells and the production of Immunoglobulin-Binding Factors (IBF). The fact that some malignant B cells are sensitive to the same factors as normal B lymphocytes opens the possibility to use cytokines as prognostic or therapeutic tools.
Fridman
W H
WH
Laboratorie d'Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000502:physiology*; D002455:Cell Division; D016207:Cytokines / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000502:physiology; D008222:Lymphokines / Q000097:blood / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000097:blood; D029584:Prostatic Secretory Proteins
D016207:Cytokines; D007136:Immunoglobulins; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors