title: The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L.
abstract: The complete amino acid sequence of bovine spleen cathepsin S has been determined. The single-chain protein contains 217 residues and has a Mr of 23,682. The primary structure was determined by sequencing of native protein and the peptides obtained by proteolytic cleavage with beta-trypsin, papaya proteinase IV and by chemical cleavage with cyanogen bromide. Comparison of the amino terminal sequences of the heavy and the light chain of bovine cathepsin L with that of bovine cathepsin S clearly indicates that the enzymes are structurally different.
authors.affiliation: Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Yugoslavia.
authors.forename: A
authors.initials: A
authors.lastname: Ritonja
authors.forename: A
authors.initials: A
authors.lastname: Colić
authors.forename: I
authors.initials: I
authors.lastname: Dolenc
authors.forename: T
authors.initials: T
authors.lastname: Ogrinc
authors.forename: M
authors.initials: M
authors.lastname: Podobnik
authors.forename: V
authors.initials: V
authors.lastname: Turk
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D056668:Cathepsin L; D002403:Cathepsins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification; D002417:Cattle; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D013154:Spleen / Q000201:enzymology
chemical_list: D010446:Peptide Fragments; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; C534281:CTSL protein, human; D056668:Cathepsin L; C028217:cathepsin S