[Immunostimulation with ibuprofen in chronic osteitis. An experimental study].
The present investigation shows that chronic posttraumatic osteitis is associated with markedly elevated prostaglandin E2 (PGE2) serum levels. Synthesis of PGE2 is inhibited by nonsteroidal antiinflammatory drugs, such as ibuprofen, which block cyclooxygenase. Osteitis patients showed significantly decreased PGE2 serum levels during treatment with ibuprofen (1200 mg/day). In addition, a significant increase in soluble interleucin-2 receptor serum levels was observed. PGE2 has significant immunosuppressive effects on cell-mediated immunity. On the other hand, soluble interleucin-2 receptor is a reliable indicator of immune system activation. Ibuprofen seems to be a potent immunostimulating agent for the treatment of chronic posttraumatic osteitis, which is characterized by depression of cell-mediated immunity.
Josten
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C
Chirurgische Universitätsklinik und Poliklinik, Berufsgenossenschaftliche Krankenanstalten, Bergmannsheil, Bochum.
Griga
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T
Muhr
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G
D015232:Dinoprostone / Q000097:blood*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000188:drug therapy / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood / Q000187:drug effects*; D013978:Tibial Fractures / Q000276:immunology*
D015375:Receptors, Interleukin-2; D015232:Dinoprostone; D007052:Ibuprofen
Immunstimulation mit Ibuprofen bei der chronischen Osteitis. Eine experimentelle Studie.