title: [Medulloblastoma in children. Current treatments and future perspectives].
abstract: The various treatments currently available for medulloblastoma are reviewed and modifications which have occurred over the last ten years are analyzed. Surgery is the first step of the treatment of a medulloblastoma. Recent advances in neurosurgical anesthesia and intensive care have substantially improved the quality and extent of exeresis and markedly reduced operative mortality (currently under 2%). Radiotherapy of the entire central nervous system should follow surgery in every case. Use of high energy radiations (together with improvements in surgical treatment) have increased survival rates to 50-60%. However, side effects are frequent. The modalities and timing of chemotherapy have also changed considerably over the last ten years; the different modalities currently used are reviewed, as well as the strategies available for reducing toxic effects and hematologic complications. Currently, chemotherapy is "sandwiched" between surgery and radiotherapy. Treatments under evaluation (monoclonal antibodies, immunotoxins, and immunomodulation) are discussed. The purpose of this therapeutic strategy for medulloblastomas is not only to increase survival rates but, above all, to improve the quality of life in survivors. Close cooperation between health care professionals of the different specialties involved and long term multicenter studies are indispensable if this goal is to be achieved.
authors.affiliation: Service d'Oncologie Pédiatrique, Hôpital d'Enfants, CHU de la Timone, Marseille.
authors.forename: J C
authors.initials: JC
authors.lastname: Gentet
authors.forename: L
authors.initials: L
authors.lastname: Genitori
authors.forename: J
authors.initials: J
authors.lastname: Mancini
authors.forename: J L
authors.initials: JL
authors.lastname: Bernard
authors.forename: C
authors.initials: C
authors.lastname: Coze
authors.forename: C
authors.initials: C
authors.lastname: Nicolas
authors.forename: C
authors.initials: C
authors.lastname: Raybaud
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005544:Forecasting; D006801:Humans; D007223:Infant; D008527:Medulloblastoma / Q000628:therapy*
vernacular_title: Médulloblastome de l'enfant. Traitements actuels et perspectives d'avenir.