title: Male-specific metabolism of simvastatin by rat liver microsomes.
abstract: Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.
authors.affiliation: Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kagami
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: M
authors.initials: M
authors.lastname: Ohtawa
mesh_terms: D000818:Animals; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D019821:Simvastatin
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin