Induction of metallothionein by simultaneous administration of cadmium(II) and zinc(II).
LLC-PK1 cells were used as a model of renal proximal tubule cells in the induction of metallothionein by cadmium(II) and zinc(II). We have found that the induction of metallothionein by either cadmium(II) or zinc(II) alone reaches a maximum which cannot be surpassed by increased amounts of the same metal. However, induction is additive when the cells are exposed to the two metals simultaneously. This indicates that the induction of metallothionein by cadmium(II) and by zinc(II) occurs by different mechanisms within these cells.
Harford
C
C
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Sarkar
B
B
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002460:Cell Line; D002852:Chromatography, Ion Exchange; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D007700:Kinetics; D008668:Metallothionein / Q000096:biosynthesis* / Q000302:isolation & purification; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D008668:Metallothionein; D015032:Zinc