title: The application of hybrid mass spectrometry/mass spectrometry and high-resolution mass spectrometry to the analysis of fish samples for polychlorinated dibenzo-p-dioxins and dibenzofurans.
abstract: A hybrid mass spectrometer operated in low-resolution selected decomposition monitoring (SDM) mode was used for the analysis of whole fish samples for the 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and poly-chlorinated dibenzofurans (PCDD/Fs). These fish samples were previously analyzed for PCDD/Fs using a high-resolution mass spectrometer following EPA protocols. The hybrid tandem mass spectrometric method using loss of COCl gave similar quantification results to those obtained by high-resolution mass spectrometry and eliminated the interferences attributed to polychlorinated biphenyls that were encountered in the high-resolution mass spectrometric analysis. Comparison of the two methods shows that the high-resolution mass spectrometric method surpasses the tandem mass spectrometric method in other analytical figures of merit, such as detection limit, linearity and reproducibility.
authors.affiliation: Connecticut Agricultural Experiment Station, New Haven 06504.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Huang
authors.forename: B
authors.initials: B
authors.lastname: Eitzer
authors.forename: C
authors.initials: C
authors.lastname: Moore
authors.forename: S
authors.initials: S
authors.lastname: McGown
authors.forename: K B
authors.initials: KB
authors.lastname: Tomer
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000032:analysis*; D000072338:Dibenzofurans, Polychlorinated; D005399:Fishes; D066298:In Vitro Techniques; D013058:Mass Spectrometry / Q000379:methods; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins