[Fluid therapy for superior mesenteric artery occlusion shock in rats].
The efficacy of three kinds of fluid such as isotonic sodium chloride (0.9% NaCl), hypertonic sodium chloride (7.5% NaCl) and iso-oncotic (3% in saline) albumin solutions to maintain the hemodynamics was investigated in rats with superior mesenteric artery occlusion (SMAO) shock. Three kinds of fluid were infused so as to maintain the mean arterial pressure within 70% of the control values. Animals in the control group without fluid therapy died within three hours because of shock. Three regimens could maintain the mean arterial blood pressure over three hours. The hypertonic crystalloid solution was effective in the early period of SMAO shock to regain the blood pressure by infusing a small volume. An excessively large amount of volume was required in the group infused with an isotonic crystalloid, providing inadequate tissue perfusion. The iso-oncotic colloid produced a stable circulatory status with minimum changes in tissue perfusion.
Ohi
Y
Y
Department of Anesthesiology, Nippon Medical School, Tokyo.
D000818:Animals; D004285:Dogs; D005440:Fluid Therapy; D008297:Male; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000150:complications / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000209:etiology / Q000628:therapy*