[Effects of naproxen (naprosyne) on the metabolism of arthrotic cartilage in man in vivo].
Degradative enzyme (proteoglycanase and collagenase) as well as proteoglycan synthesis enzyme (glycosyl-transferase) activity was studied in osteoarthritic fibrillated cartilage. Proteoglycanase activity was significantly lower in 10 patients with hip osteoarthritis treated with Naproxen (1 g/daily for 4 weeks) than in 10 patients treated with acetaminophen. Synthesis enzyme activity was similar in both groups. The results which confirm in vitro studies suggest that naproxen has not toxic effect on human osteoarthritic cartilage and could rather be beneficial.
Vignon
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E
Laboratoire d'Exploration Articulaire, Hôpital Edouard-Herriot, Lyon.
Mathieu
P
P
Charlet
C
C
Balblanc
J C
JC
Richard
M
M
D000082:Acetaminophen / Q000494:pharmacology; D000284:Administration, Oral; D000368:Aged; D002358:Cartilage, Articular / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015207:Osteoarthritis, Hip / Q000188:drug therapy* / Q000201:enzymology; D011446:Prospective Studies
D000082:Acetaminophen; D009288:Naproxen
Effets du naproxène (Naprosyne) sur le métabolisme du cartilage arthrosique chez l'homme in vivo.