title: Bricanyl Turbuhaler and Ventolin Rotahaler in exercise-induced asthma in children.
abstract: Bricanyl Turbuhaler (0.5 mg terbutaline sulphate) and Ventolin Rotahaler (0.4 mg salbutamol) were compared in a randomized double-blind placebo controlled study on exercise-induced asthma in 19 children (14 boys) aged 7-14 years. The study was carried out on 3 separate days. Asthmatic attacks were provoked by free range running. Peak expiratory flow (PEF) was measured before and after exercise. If PEF decreased by greater than 20%, one inhalation from each of the inhalers was given under supervision of the investigator. Only one of the inhalers (none on the placebo day) delivered active drug. PEF was measured again 5 and 10 min after treatment. Already 5 min after treatment PEF had returned to baseline after active treatment. There was no statistically significant difference between the two active treatments. After placebo treatment, PEF did not return to baseline even at the 10 min post-exercise measurement. Ten children needed extra medication after the last PEF measurement on the placebo day, whereas no child needed extra medication after any of the active treatments. No adverse events were reported in this study. In conclusion, Bricanyl Turbuhaler (0.5 mg) and Ventolin Rotahaler (0.4 mg) were equally efficacious in the treatment of exercise-induced asthma in children.
authors.affiliation: Serviço de Pediatria, Centro Hospitalar de Vila Nova de Gaia, Portugal.
authors.forename: J M
authors.initials: JM
authors.lastname: dos Santos
authors.forename: H
authors.initials: H
authors.lastname: Costa
authors.forename: E
authors.initials: E
authors.lastname: Ståhl
authors.forename: J E
authors.initials: JE
authors.lastname: Wirén
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D016084:Bronchoconstriction / Q000187:drug effects; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D013726:Terbutaline; D000420:Albuterol