Transient and long-lasting beneficial behavioral effects of grafts in the damaged hippocampus of rat.
One week after receiving bilateral neurotoxic lesions of their dorsal hippocampi, adult Wistar rats were bilaterally grafted with fetal hippocampal tissue suspensions. The behavior of the animals was tested during a period of 5 months after grafting to determine changes in lesion-induced deficits. The transplants caused various behavioral effects with different time courses. Grafted animals showed an early, however, transient amelioration of behavioral deficits in a T-maze alternation task and they performed with a long-lasting improvement in the alcove-test. Transplant histology demonstrated high levels of AChE-activity in patches correlating with clusters or rudimentary layers of pyramidal neurons.
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C. and O. Vogt-Institute of Brain Research, University of Düsseldorf, F.R.G.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D048588:Benzoxazines; D016380:Brain Tissue Transplantation; D005260:Female; D016332:Fetal Tissue Transplantation; D006624:Hippocampus / Q000196:embryology / Q000502:physiology / Q000637:transplantation*; D008297:Male; D010078:Oxazines; D011247:Pregnancy; D011712:Pyramidal Tracts / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver; D014184:Transplantation, Homologous
D048588:Benzoxazines; D010078:Oxazines; C028911:cresyl violet; D012834:Silver; D000110:Acetylcholinesterase