title: Detection of 3,6-dinitrobenzo[a]pyrene in airborne particulates.
abstract: 3,6-Dinitrobenzo[a]pyrene, a new mutagen, was detected in airborne particulates collected in Santiago (Chile). The quantity of the compound in the airborne particulates was very small, accounting for 0.01 micrograms/g of total particulates (0.002 ng/m3 of air) at the lowest concentration. It was found that 3,6-dinitrobenzo[a]pyrene is readily decomposed by UV irradiation at 312 nm. The decomposed product was identified as 3-nitrobenzo[a]pyrene-6-quinone by means of mass spectrometry and proton nuclear magnetic resonance analysis. The mutagenicity of 3,6-dinitrobenzo[a]pyrene was 137,000 revertants/nmole for Salmonella typhimurium strain TA98, less than that for strain TA98/1,8-DNP6, an acetyltransferase-deficient mutant, and more than that for strain YG1024, an acetyltransferase-rich mutant.
authors.affiliation: Department of Health Science, Fukuoka Environmental Research Center, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sera
authors.forename: M
authors.initials: M
authors.lastname: Kai
authors.forename: K
authors.initials: K
authors.lastname: Horikawa
authors.forename: K
authors.initials: K
authors.lastname: Fukuhara
authors.forename: N
authors.initials: N
authors.lastname: Miyata
authors.forename: H
authors.initials: H
authors.lastname: Tokiwa
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000633:toxicity* / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D000393:Air Pollutants; D009153:Mutagens; C068923:3,6-dinitrobenzopyrene; D001564:Benzo(a)pyrene