Properties of a deep Proteus R mutant isolated from clinical material.
Some biological features of a deep P. mirabilis 17301 R mutant isolated from the urine of a patient with chronic UTI were studied and compared with similar features of P. mirabilis S forms and five induced Proteus R mutants of different chemotypes. There were no differences in lethal toxicity and adhesion to human uroepithelial cells. Of all the R mutants tested, two of them, 17301 and R4, exhibited strong cell-bound hemolytic activity. The P. mirabilis R 17301 was characterized as the most invasive (tested in L929 mouse fibroblasts) compared to the other Proteus S and R forms. The structure of PS from a clinical R mutant investigated and the results of serological studies prove that this mutant belongs to the Rc chemotype.
Krajewska-Pietrasik
D
D
Institute of Microbiology, University of Lódź, Poland.
Rózalski
A
A
Bartodziejska
B
B
Radziejewska-Lebrecht
J
J
Mayer
H
H
Kotełko
K
K
D000818:Animals; D001422:Bacterial Adhesion; D002478:Cells, Cultured; D006801:Humans; D008070:Lipopolysaccharides / Q000032:analysis / Q000276:immunology; D051379:Mice; D009154:Mutation; D009844:Oligosaccharides / Q000032:analysis; D011513:Proteus mirabilis / Q000032:analysis / Q000145:classification* / Q000276:immunology; D014510:Urease / Q000032:analysis; D014552:Urinary Tract Infections / Q000382:microbiology
D008070:Lipopolysaccharides; D009844:Oligosaccharides; D014510:Urease