[The prognostic value of a mucin histochemical study for the detection of a elevated risk of recurrence after surgical therapy of colorectal carcinoma].
Increased sialomucin production may occur in mucosa surrounding malignant colorectal tumors. The authors examined the value of sialomucin production for prognostication of subsequent local tumour recurrence. Colorectal mucosa was evaluated from 73 patients who had undergone curative surgery for colorectal carcinoma. Sialomucin production was semi-quantitatively measured, using a high iron-diamine/alcian-blue staining technique. Significant increases in sialomucin production was recorded from mucosa, at least along resection margins, from 17 in 39 patients (44%) who did not develop any local recurrence. On the other hand, increased sialomucin synthesis was recordable from only 10 of 27 patients (37%) who did develop local recurrence. Moreover, only one of 7 patients who developed metachronous recurrence had exhibited sialomucins predominantly on resection margins. These findings are likely to suggest that evidence to increased sialomucin production is not conclusively indicative of high risk of local recurrence.
Hagmüller
E
E
Chirurgische Klinik Mannheim, Universität Heidelberg, BRD.
Piltz
S
S
Saeger
H D
HD
D003082:Colectomy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D009077:Mucins / Q000032:analysis / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011379:Prognosis; D012007:Rectum / Q000601:surgery; D052116:Sialomucins
D009077:Mucins; D052116:Sialomucins
Der prognostische Wert einer muzinhistochemischen Untersuchung zur Erkennung eines erhöhten Rezidivrisikos nach chirurgischer Therapie des kolorektalen Karzinoms.