[The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid].
Preneoplastic changes in organ cultures of mouse embryonic kidney (OCEK) under transplacental N-nitrosoethyl urea (ENU) did not increase under the influence of Ado-Cbl. The frequency of focal proliferation in OCEK under transplacental influence of Ado-C bl and ENU was 2.2 times less than the combination of carcinogen with MeCbl (32.2% and 71.9%, respectively, P less than 0.01). The number of DNA-synthesising epithelial cells in OCEK were less under transplacental influence of Ado-Cbl (8.6 +/- 1.4%) than in MeCbl or FA (19.4 +/- 1.8% and 16.2 +/- 1.3% respectively, P less than 0.01).
Golenko
O D
OD
Ryzhova
N I
NI
Miasishcheva
N V
NV
D000818:Animals; D003038:Cobamides / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000196:embryology / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D002955:Leucovorin / Q000494:pharmacology*; D051379:Mice; D009924:Organ Culture Techniques; D010920:Placenta; D011247:Pregnancy; D013997:Time Factors; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology
D003038:Cobamides; C019476:mecobalamin; C000913:cobamamide; D014805:Vitamin B 12; D005038:Ethylnitrosourea; D002955:Leucovorin
Kantserogennaia aktivnost' N-nitrozo-N-étilmocheviny v organnykh kul'turakh pochek mysheĭ pri transplatsentarnom vozdeĭstvii s kobalaminovymi kofermentami i folinovoĭ kislotoĭ.