[Distribution in mice of 125I-monoclonal antibodies to T-lymphocyte antigen Ly 2.1 under the influence of immunomodulators].
A study was made of the distribution of 125I (a chloramine method of labeling) monoclonal antibodies to the surface antigen Ly 2.1 of T-lymphocytes during action of immunomodulators (tactivin, hydrocortisone, tactivin administered after hydrocortisone) on ACR mice. These antibodies were shown to retain antigen binding capacity, permitting monitoring of the redistribution of the antigen in the body exposed to immunomodulators.
Miroliubova
O Iu
OIu
Fadeev
N P
NP
Serzhanina
V A
VA
Klimovich
V B
VB
Makarenko
M V
MV
Korsakova
L N
LN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics*; D000950:Antigens, Ly / Q000276:immunology*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D010455:Peptides / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013949:Thymus Extracts / Q000494:pharmacology; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D007457:Iodine Radioisotopes; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D006854:Hydrocortisone
Raspredelenie u mysheĭ 125I monoklonal'nykh antitel k antigenu Ly 2.1 T-limfotsitov pod vliianiem immunomoduliatorov.