Effect of intraperitoneally administered beta-1,3-glucan, SSG, obtained from Sclerotinia sclerotiorum IFO 9395 on the functions of murine alveolar macrophages.
The effect of intraperitoneally (i.p.) administered SSG, a beta-1,3-glucan obtained from the culture filtrate of the fungus Sclerotinia sclerotiorum IFO 9395, on the functions of alveolar macrophages (AM) in CDF1 mice was examined. SSG administered i.p. increased the number of AM and enhanced several functions of murine AM (lysosomal enzyme activity, phagocytic activity, candidacidal activity, H2O2 production and interleukin 1 (IL-1) production) at a dose of 250 micrograms/mouse on days 1 and 8, especially on day 8. Furthermore, SSG (250 micrograms/mouse) administered i.p. for 10 consecutive days significantly inhibited the experimental pulmonary metastasis of Lewis Lung Carcinoma (3LL) on BDF1 mice.
Sakurai
T
T
Tokyo College of Pharmacy, Japan.
Suzuki
I
I
Kinoshita
A
A
Oikawa
S
S
Masuda
A
A
Ohsawa
M
M
Yadomae
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000378:metabolism; D005936:Glucans / Q000008:administration & dosage / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D011650:Pulmonary Alveoli / Q000166:cytology; D047071:beta-Glucans
D000970:Antineoplastic Agents; D005936:Glucans; D007155:Immunologic Factors; D047071:beta-Glucans; C033363:beta-1,3-glucan