title: Pinocembrine: a bioactive flavanone from Teloxys graveolens.
abstract: Bioactivity directed fractionation of the acetone extract of Teloxys graveolens (Willd.) Weber (Chenopodiaceae), using the brine shrimp lethality test, led to the isolation of 5,7-dihydroxyflavanone (pinocembrine) (LC50 = 4.25 micrograms/ml) as the only active compound. Pinocembrine also exhibited fasciolicide, ovicide and larvicide activities on newly excysted Fasciola hepatica, on infective eggs of Ascaridi galli and on stage three larvae of Stomoxys calcitrans, respectively.
authors.affiliation: Division de Bioquimica y Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F.
authors.forename: M
authors.initials: M
authors.lastname: Del Rayo Camacho
authors.forename: B
authors.initials: B
authors.lastname: Sanchez
authors.forename: H
authors.initials: H
authors.lastname: Quiroz
authors.forename: J L
authors.initials: JL
authors.lastname: Contreras
authors.forename: R
authors.initials: R
authors.lastname: Mata
mesh_terms: D000818:Animals; D000871:Anthelmintics; D001156:Artemia; D001197:Ascaridia / Q000187:drug effects; D005210:Fasciola hepatica / Q000187:drug effects; D005260:Female; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D007313:Insecta; D007306:Insecticides; D007814:Larva / Q000187:drug effects; D008297:Male; D008800:Mexico; D010936:Plant Extracts / Q000032:analysis*; D010946:Plants, Medicinal
chemical_list: D000871:Anthelmintics; D044950:Flavanones; D005419:Flavonoids; D007306:Insecticides; D010936:Plant Extracts; C016063:pinocembrin