The d-spacing of collagen from mitral heart valves changes with ageing, but not with collagen type III content.
A low angle X-ray diffraction study of normal and myxomatous human heart valves has been carried out using a Synchrotron radiation source. This study has shown a slight progressive decrease in the d-spacing of the collagen with age. Despite suggestions reported in the literature, no significant relative change was observed in the d-spacing with the increase in the percentage of collagen type III from 24% in normal to 31% in myxomatous heart valves.
James
V J
VJ
Department of Biophysics, Rex Vowels Low Angle Diffraction Laboratory, University of New South Wales, Kensington, Australia.
McConnell
J F
JF
Capel
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002648:Child; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006338:Heart Neoplasms / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000378:metabolism*; D009232:Myxoma / Q000378:metabolism; D013552:Swine; D014961:X-Ray Diffraction
D003094:Collagen