Leprosy and cell-mediated immunity.
The intradermal injection of the purified protein derivative of tuberculin into lepromatous leprosy patients leads to a local cell-mediated immune response and to the extensive destruction of Mycobacterium leprae. This local response also occurs after intradermal injection of recombinant human interleukin-2; when administered over an 8-day period interleukin-2 evokes a systemic cell-mediated immune response and a reduction in the bacillary burden.
Kaplan
G
G
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021.
Cohn
Z A
ZA
D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D007918:Leprosy / Q000276:immunology*; D008213:Lymphocyte Activation / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D051379:Mice; D010586:Phagocytes / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D008222:Lymphokines