title: Ammonia levels in paediatric ureterosigmoidostomy patients: a screen for hyperammonaemia?
abstract: Hyperammonaemia in the urological patient is a rare and potentially grave condition. It has been reported most frequently in association with ureterosigmoidostomy, where clinical neurological symptoms have developed abruptly in association with markedly elevated plasma ammonia levels. The purpose of this study was to determine whether ureterosigmoidostomy patients might have subclinically elevated plasma ammonia levels, which would put them at risk of subsequently developing hyperammonaemic encephalopathy. Both urine and plasma ammonia levels were assayed in 10 asymptomatic paediatric urological patients with ureterosigmoidostomy. Ten paediatric colocystoplasty patients served as controls. Urine pH and urine ammonia levels were significantly higher in the ureterosigmoidostomy group. There was no significant difference in plasma ammonia levels between ureterosigmoidostomy and colocystoplasty patients. In none of the patients was the plasma ammonia level elevated, but 1 ureterosigmoidostomy patient had an exceedingly high urine ammonia level. It was concluded that an annual serum ammonia level in an asymptomatic ureterosigmoidostomy patient is probably not a valuable screen for subclinical hyperammonaemia.
authors.affiliation: University of Massachusetts Medical Center, Worcester.
authors.forename: D A
authors.initials: DA
authors.lastname: Diamond
authors.forename: A
authors.initials: A
authors.lastname: Blight
authors.forename: C T
authors.initials: CT
authors.lastname: Samuell
authors.forename: P G
authors.initials: PG
authors.lastname: Ransley
mesh_terms: D000293:Adolescent; D000641:Ammonia / Q000097:blood* / Q000652:urine; D002648:Child; D003106:Colon / Q000601:surgery; D012809:Colon, Sigmoid / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013997:Time Factors; D014519:Ureterostomy / Q000009:adverse effects*; D014547:Urinary Diversion / Q000009:adverse effects*; D014556:Urine / Q000502:physiology
chemical_list: D000641:Ammonia