The role of penicillin amidases in nature and in industry.
Penicillin amidase (PA) is the enzyme used commercially for the production of semisynthetic penicillins. During the past decade, a detailed picture of the structure and regulation of the gene encoding this enzyme has emerged, revealing a variety of interesting features that are unique among microorganisms. Clues to the biological role of this enzyme have been provided, as well as new strategies for the commercial production and utilization of PA.
Valle
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F
Centro de Investigación sobre, Ingeniería Genética y Biotecnologia, Universidad Nacional Autónoma de México.
Balbás
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P
Merino
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E
Bolivar
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F
D004926:Escherichia coli / Q000201:enzymology*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D005818:Genetic Engineering / Q000379:methods; D010399:Penicillin Amidase / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000502:physiology; D011549:Pseudomonas / Q000201:enzymology
D010399:Penicillin Amidase