title: Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.
abstract: (S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.
authors.affiliation: Rega Institute for Medical Research, Leuven, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Augustyns
authors.forename: A
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: A
authors.initials: A
authors.lastname: Van Schepdael
authors.forename: C
authors.initials: C
authors.lastname: Urbanke
authors.forename: P
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry; D001482:Base Composition; D004795:Enzyme Stability; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism; D013696:Temperature
chemical_list: D009838:Oligodeoxyribonucleotides; D011108:Polymers; C069128:9-(3,4-dihydroxybutyl)adenine; D000225:Adenine