title: Morphology and pathogenesis of endocrine hyperplasias, precarcinoid lesions, and carcinoids arising in chronic atrophic gastritis.
abstract: The spectrum of endocrine cell changes occurring in 80 cases of body-fundus chronic atrophic gastritis (CAG), mostly type A or multifocal, including various types of hyperplasia, precarcinoid lesions (20 cases), and neoplasia (carcinoid, 24 cases) have been analyzed histologically, histochemically, and ultrastructurally. Changes associated with gland atrophy, pyloric- or intestinal-type metaplasia, regenerative hyperplasia, and hypergastrinemia have been identified and their neoplastic potential evaluated in the light of their proliferative capacity (bromodeoxyuridine incorporation) and clinicopathologic behavior. A close link between disseminated precarcinoid lesions of non-tumor mucosa and multiple carcinoids (carcinoidosis) arising in hypergastrinemic type-A CAG is suggested. Hyperplastic changes, including endocrine cell clusters, seem to have no or only minimal neoplastic potential.
authors.affiliation: Dept. of Human Pathology, Ist Medical Faculty, University of Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Solcia
authors.forename: R
authors.initials: R
authors.lastname: Fiocca
authors.forename: L
authors.initials: L
authors.lastname: Villani
authors.forename: A
authors.initials: A
authors.lastname: Gianatti
authors.forename: M
authors.initials: M
authors.lastname: Cornaggia
authors.forename: A
authors.initials: A
authors.lastname: Chiaravalli
authors.forename: M
authors.initials: M
authors.lastname: Curzio
authors.forename: C
authors.initials: C
authors.lastname: Capella
mesh_terms: D002276:Carcinoid Tumor / Q000209:etiology / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000032:analysis; D004759:Enterochromaffin Cells / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D006984:Hypertrophy; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology*
chemical_list: D006063:Chorionic Gonadotropin