Family distances as a measure of hidden consanguinity. A reappraisal.
We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.
Swaving
J
J
Department of Medical Genetics, University of Groningen, The Netherlands.
Groenewegen
A
A
Kamstra
A
A
te Meerman
G J
GJ
ten Kate
L P
LP
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D009426:Netherlands; D010375:Pedigree; D015995:Prevalence; D011897:Random Allocation; D012424:Rural Population; D014505:Urban Population