Serial measurements of anticardiolipin antibodies in primary Sjögren's syndrome.
Twenty-four out of 54 patients with primary Sjögren's syndrome (SS) were shown to be positive for IgG and/or IgM anticardiolipin antibodies (aCL). Extraglandular manifestations were related to the IgG-, but not to the IgM-aCL. Twenty SS patients were examined over a 3 year period. Of these, 6 displayed a marked increase in IgG- and IgM-aCL and, among them, 4 developed extraglandular manifestations of SS throughout the follow-up.
Pennec
Y L
YL
Department of Internal Medicine, Brest University Medical School, France.
Magadur
G
G
Jouquan
J
J
Youinou
P
P
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology*
D000906:Antibodies; D000974:Antibodies, Antinuclear; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M