Elimination of testicular regression by 12-hr temporal relationship of serotonergic and dopaminergic activity in Indian palm squirrel, Funambulus pennanti.
Specific temporal relationship (12-hr) of serotonin and dopamine activity was induced by precursor drugs (5-HTP and L-DOPA) in Indian Palm Squirrel Funambulus pennanti during testicular regression phase. This treatment established breeding condition unlike control, which experienced complete atrophy of testes and accessory sex organs. It is obvious that seasonal testicular regression of Indian Palm Squirrel can be eliminated by 12 hr relation of 5-HTP and L-DOPA, which is not a pharmacological effect but actually is an alteration of seasonality in this annually breeding subtropical mammal. It may be concluded that specific phase relation (12-hr) between circadian serotonergic and dopaminergic oscillations may induce breeding condition in regressing gonad of Indian Palm Squirrel during post-reproductive phase of annual gonadal cycle. It is also suggested that inspite of the different environmental factors (photoperiod, humidity etc.) used by different species to time their annual reproduction, basic regulatory mechanism of seasonality appears to be the same, i.e., temporal synergism of neurotransmitter activity.
Jaiwal
R
R
Department of Zoology, Banaras Hindu University, Varanasi, India.
Chaturvedi
C M
CM
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005837:Genitalia, Male / Q000187:drug effects / Q000502:physiology; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012589:Sciuridae / Q000502:physiology*; D012621:Seasons; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013737:Testis / Q000502:physiology*
D012701:Serotonin; D007980:Levodopa; D004298:Dopamine