Growth inhibitory activities in avascular tissues are recognized by anti-transforming growth factor beta antibodies.
The aqueous and vitreous humors are normally avascular and may be sites of altered inflammatory responses. Inhibitors of endothelial cell and lymphocyte growth as well as of angiogenesis have been isolated from vitreous and an inhibitor of lymphocyte mitogenesis has been found in aqueous. Data are presented here indicating that aqueous humor also inhibits endothelial cell growth. In addition, neutralizing antibodies against TGF beta block the effects of materials isolated from these tissues on endothelial cell and lymphocyte growth. Similar data were obtained from aorta, another normally avascular site. These observations suggest that the avascularity and altered inflammatory responses in these sites may be regulated in part by TGF beta.
Eisenstein
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R
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Milwaukee 53233.
Grant-Bertacchini
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D
D000818:Animals; D000906:Antibodies / Q000502:physiology; D001082:Aqueous Humor / Q000166:cytology* / Q000276:immunology; D002417:Cattle; D002455:Cell Division; D004730:Endothelium, Vascular / Q000166:cytology* / Q000276:immunology; D006131:Growth Inhibitors / Q000276:immunology / Q000502:physiology*; D008214:Lymphocytes; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000502:physiology*; D014822:Vitreous Body / Q000166:cytology* / Q000276:immunology
D000906:Antibodies; D006131:Growth Inhibitors; D016212:Transforming Growth Factor beta