Fulminant pulmonary aspergillus infection occluding the aortic arch after high-dose antileukemic chemotherapy.
After antileukemic chemotherapy a granulocytopenic patient experienced a rapidly progressive left-sided pneumonia with pleuritic pain. After 1 week, a sudden occlusion of all aortic branches was followed by death. At postmortem, a huge thrombus in the aortic arch caused by Aspergillus invasion from the left lung was found.
Kluin-Nelemans
J C
JC
Department of Hematology, University Hospital Leiden, The Netherlands.
Koelma
I A
IA
van der Merwe
P C
PC
Peetermans
W E
WE
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001013:Aorta, Thoracic / Q000473:pathology; D001018:Aortic Diseases / Q000473:pathology*; D001228:Aspergillosis / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008172:Lung Diseases, Fungal / Q000473:pathology*; D008297:Male; D013927:Thrombosis / Q000473:pathology*