Free radicals scavengers attenuate platelet-activating factor (PAF)- and endotoxin-induced intestinal myoelectric disturbances in rats.
Pretreatment with radical scavengers significantly reduced the intestinal myoelectric disturbances following either E. coli endotoxin or platelet-activating factor (PAF) injection in the rat indicating that free radicals might be involved in the intestinal motor alterations observed in endotoxin shock and that PAF acts partially via free radical production. Moreover, dimethylsulfoxide (DMSO) was found to be more effective in inhibiting the endoxotin-induced intestinal motor alterations, than superoxide dismutase (SOD) and allopurinol. BN 52021, a specific PAF antagonist, was able to reduce the effects of endotoxin on intestinal motility. However, when BN 52021 was combined with free radical scavengers, no additive effect was observed. It is concluded that free radicals involved in endotoxin-induced intestinal motility alterations are at least in part produced in response to PAF.
Pons
L
L
Department of Pharmacology INRA, Toulouse, France.
Droy-Lefaix
M T
MT
Braquet
P
P
Buéno
L
L
D000818:Animals; D004224:Diterpenes; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D016166:Free Radical Scavengers; D046934:Ginkgolides; D007422:Intestines / Q000187:drug effects*; D007783:Lactones / Q000494:pharmacology; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004224:Diterpenes; D004731:Endotoxins; D016166:Free Radical Scavengers; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B