[Intracranial fibrous xanthoma (xanthofibroma) in an infant: a case report].
A case of intracranial fibrous xanthoma (xanthofibroma) is reported. Intracranial fibrous xanthoma in infancy under the age of 1 year is extremely rare. This patient was a 8-month-old boy with a history of convulsive seizure. He had a previously known chest wall tumor which was diagnosed as fibrous xanthoma of the skin. Plain CT scan revealed a well defined high density area in the left temporal lobe. The area was well enhanced with contrast media. At operation, it was found that the tumor did not attach to dura mater and was almost well demarcated. Total removal of the tumor was performed. The patient has been doing well for these 6 months following craniotomy, with no sings of recurrence and no neurological deficits. Histologically, the tumor was composed of fibroblastic cells and foamy phagocytic cells in storiform pattern. Some multinucleated giant cells were found. Immunohistochemistry technique revealed that the tumor cells were negative for GFAP, positive for Vimentin, positive for S-100 protein and negative for EMA. Our studies support the diagnosis of intracranial fibrous xanthoma coexistent with the same tumor found in the subcutaneous space of the chest wall of a boy under 1 year of age. We regard it as a rare incidence. Differential diagnosis and the characteristics of fibrous xanthoma were discussed.
Ohmori
Y
Y
Department of Neurosurgery, Kyoto 2nd Red Cross Hospital, Japan.
Kubo
S
S
Yasukouchi
K
K
Takemi
K
K
Ikeda
M
M
Ibayashi
N
N
D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D005350:Fibroma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary; D013899:Thoracic Neoplasms / Q000473:pathology / Q000601:surgery