title: Two cases of fatal intoxication due to tranylcypromine overdose.
abstract: Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine were determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derivatized with trifluoroacetic anhydride and analyzed by gas chromatography with nitrogen-phosphorus selective detection. The method was linear in blood over the range 0.5-20 mg/L with a limit of quantitation of about 0.2 mg/L.
authors.affiliation: Chemistry Division, Department of Scientific and Industrial Research, Auckland, New Zealand.
authors.forename: P J
authors.initials: PJ
authors.lastname: Boniface
mesh_terms: D002849:Chromatography, Gas; D062787:Drug Overdose / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014191:Tranylcypromine / Q000378:metabolism / Q000506:poisoning*
chemical_list: D014191:Tranylcypromine