Coronary vasospasm secondary to labetalol in a patient with aortic dissection.
A 66-year-old hypertensive woman presented with epigastric and scapular pain on the basis of type 3 aortic dissection. Appropriate therapy with a combined alpha-adrenergic and beta-adrenergic antagonist agent prevented further ongoing dissection and amelioration of symptoms. On day 5, an episode of coronary vasospasm occurred presumably due to beta-blockade with unopposed alpha-adrenergic activity.
Sandler
M A
MA
Division of Cardiovascular Disease, Albert Einstein Medical Center, Philadelphia 19141.
Jacobs
L E
LE
Kotler
M N
MN
D000368:Aged; D000784:Aortic Dissection / Q000150:complications; D001013:Aorta, Thoracic; D001014:Aortic Aneurysm / Q000150:complications*; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007741:Labetalol / Q000009:adverse effects* / Q000627:therapeutic use
D007741:Labetalol