Low prevalence of osteomalacia in elderly patients with hip fracture.
In order to establish the prevalence of osteomalacia in elderly patients with hip fracture, trans-iliac biopsies were obtained from 49 patients, aged 67-92 years, admitted to Cardiff Royal Infirmary with hip fracture. Undecalcified sections were quantitatively assessed and the diagnosis of osteomalacia was made when there was an increase in mean osteoid seam width (greater than 15 microns) associated with a reduction in calcification fronts (less than 60% of osteoid-covered surfaces). Osteomalacia was present in only one patient; in the remaining patients, osteoid surface extent, volume and mean seam width were within normal limits. Thus osteomalacia, when defined by rigorous histomorphometric criteria, was rare in these elderly subjects with hip fracture.
Compston
J E
JE
Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff.
Vedi
S
S
Croucher
P I
PI
D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006620:Hip Fractures / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D014852:Wales / Q000453:epidemiology