[Alpha- and gamma-endorphin suppression of the chronotropic effects of exogenous acetylcholine].
On the isolated frog heart alpha- and gamma-endorphins depressed the chronotropic effects of exogenous acetylcholine. Naloxone partially blocked the atropine-like action of alpha-, gamma-endorphins. The latent period of the reaction to the endorphin injection was about 20 min, the endorphin effect retained more than 1 h. The obtained data show that some opioids may act as "endogenous atropine".
Sokolova
N A
NA
Ashmarin
I P
IP
D000109:Acetylcholine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D009270:Naloxone / Q000494:pharmacology; D001615:beta-Endorphin / Q000494:pharmacology
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; D000109:Acetylcholine
Podavlenie al'fa- i gamma-éndorfinami khronotropnykh éffektov ékzogennogo atsetilkholina.