Postnatal development of mouse alcohol dehydrogenases: agarose isoelectric focusing analyses of the liver, kidney, stomach and ocular isozymes.
The postnatal development of alcohol dehydrogenase (ADH) isozymes was studied in liver, kidney, stomach and eye tissues of C57BL/6J inbred male mice using agarose isoelectric focusing and histochemical methods. Development profiles were tissue specific, with adult patterns being attained by 30 days in the liver and stomach, and by 42 days in the kidneys. Ocular ADH-C2 increased in activity at the end of the first week, corresponding to the time of eye opening in the neonate.
Rout
U K
UK
Division of Science and Technology, Griffith University, Brisbane, Australia.
Holmes
R S
RS
D000367:Age Factors; D000426:Alcohol Dehydrogenase / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D005123:Eye / Q000201:enzymology*; D007525:Isoelectric Focusing / Q000379:methods; D007527:Isoenzymes / Q000032:analysis*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012685:Sepharose; D013270:Stomach / Q000201:enzymology*
D007527:Isoenzymes; D012685:Sepharose; D000426:Alcohol Dehydrogenase