title: Fibrin glue sealing of pancreatic injuries, resections, and anastomoses.
abstract: Fibrin glue made with highly concentrated human fibrinogen and clotting factors was evaluated as a means of preventing pancreatic fistulas in 15 patients operated on for traumatic and nontraumatic conditions. Fibrin glue was applied directly to penetrating pancreatic injuries, pancreatic suture and staple lines in patients treated by partial resection, and pancreaticointestinal anastomoses. Postoperatively, no patient developed pancreatic fistulas, pancreatic abscesses, or pseudocysts. Fibrin glue sealing of pancreatic injuries, resections, and anastomoses may aid in preventing fistulas after pancreatic surgery. Additional potential uses include the sealing of pancreatic biopsy sites and occlusion of the pancreatic duct in pancreatic transplantation.
authors.affiliation: Department of Surgery, Los Angeles County King/Drew Medical Center, California 90059.
authors.forename: H B
authors.initials: HB
authors.lastname: Kram
authors.forename: S R
authors.initials: SR
authors.lastname: Clark
authors.forename: H P
authors.initials: HP
authors.lastname: Ocampo
authors.forename: M A
authors.initials: MA
authors.lastname: Yamaguchi
authors.forename: W C
authors.initials: WC
authors.lastname: Shoemaker
mesh_terms: D000714:Anastomosis, Surgical; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care; D010179:Pancreas / Q000293:injuries* / Q000601:surgery*; D010180:Pancreatectomy; D010185:Pancreatic Fistula / Q000517:prevention & control*; D010193:Pancreaticojejunostomy; D010195:Pancreatitis / Q000601:surgery; D013528:Surgical Staplers; D013537:Sutures
chemical_list: D015718:Fibrin Tissue Adhesive