title: Healing of colonic anastomoses: comparative experimental study of glued, manually sutured, and stapled anastomoses.
abstract: In 10 pigs a nonsutured, glued colonic anastomosis was constructed with a modified stapling device without staples and compared with an EEA-stapled anastomosis and a one-layer-sutured anastomosis concerning radiologic appearance, breaking strength, circulation, and collagen concentration. 141Ce-labeled microspheres were used for measurements of the anastomotic blood flow before the animals were sacrificed on the 4th postoperative day. The breaking strength was recorded and an anastomotic index calculated. No leakage was found. The anastomotic width did not differ between the groups, but the interindividual variation was more prominent in the sutured group. The handsewn and stapled anastomoses were stronger than the glued anastomosis (P = 0.0009 and 0.0054, respectively). There was an increase in the anastomotic circulation in all of the anastomoses, but no differences were seen between groups. The collagen concentration was independent of the technique used.
authors.affiliation: Department of Surgery, Lund University, Sweden.
authors.forename: O K
authors.initials: OK
authors.lastname: Jansson
authors.forename: T L
authors.initials: TL
authors.lastname: Zilling
authors.forename: B S
authors.initials: BS
authors.lastname: Walther
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001783:Blood Flow Velocity; D002565:Cerium Radioisotopes; D003094:Collagen / Q000032:analysis; D003106:Colon / Q000737:chemistry / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive; D008297:Male; D008863:Microspheres; D011859:Radiography; D013528:Surgical Staplers; D013537:Sutures; D013552:Swine; D013718:Tensile Strength; D014945:Wound Healing / Q000502:physiology*
chemical_list: D002565:Cerium Radioisotopes; D015718:Fibrin Tissue Adhesive; D003094:Collagen