Evaluation of circulating tumor necrosis factor-alpha in patients with gynecological malignancies.
TNF-alpha levels in sera from patients with gynecological cancers were evaluated by ELISA and compared with those of patients with benign ovarian cysts or of anonymous healthy donors. Patients with cervical and endometrial carcinoma and with benign ovarian cysts showed levels of TNF-alpha similar to those of healthy donors. In contrast, significantly increased levels of TNF-alpha were found in patients with ovarian carcinoma, regardless of the stage of disease.
De Jaco
P
P
II Clinica Ostetrica e Ginecologica, Università di Bologna, Italy.
Asselain
B
B
Orlandi
C
C
Fridman
W H
WH
Teillaud
J L
JL
D014408:Biomarkers, Tumor / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood*; D006801:Humans; D009367:Neoplasm Staging; D010048:Ovarian Cysts / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood
D014408:Biomarkers, Tumor; D014409:Tumor Necrosis Factor-alpha