The hypotensive activity of Crotalus atrox (western diamondback rattlesnake) venom: identification of its origin.
Viperidae snakes belonging to the genus Crotalus, subfamily Crotalinae, include the species durissus terrificus, durissus durissus, adamanteus, atrox, cerastes, horridus, molossus, scutulatus, viridis and others. All of them, except for the first 2, are found in North America. Crotalus atrox, or diamondback rattlesnakes, live in the southwest United States and in Mexico. This paper describes the fractionation of C. atrox venom in order to isolate and identify its hypotensive agents.
de Mesquita
L C
LC
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
Selistre
H S
HS
Giglio
J R
JR
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003435:Crotalid Venoms / Q000737:chemistry / Q000633:toxicity*; D004590:Electrophoresis, Paper; D004591:Electrophoresis, Polyacrylamide Gel; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D003435:Crotalid Venoms