A pilot study of stanozolol for advanced breast carcinoma.
Eighteen patients with advanced metastatic carcinoma of the breast who had been previously treated with other hormone therapy were treated with stanozolol in a pilot study to assess its efficacy and toxicity. In a heavily pretreated population of patients with advanced breast cancer, three patients (16.6%) had partial responses (PR) and five patients (27.7%) had stable disease (SD). Toxicity was far less than that expected with androgen therapy. Stanozolol should be investigated in large groups of patients to establish its role more fully in the management of metastatic breast carcinoma.
Daniel
F
F
Department of Radiotherapy and Oncology, Freedom Fields Hospital, Plymouth, Devon, United Kingdom.
Rao
D G
DG
Tyrrell
C J
CJ
D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008535:Megestrol / Q000031:analogs & derivatives / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D010865:Pilot Projects; D012074:Remission Induction; D013197:Stanozolol / Q000627:therapeutic use*; D013629:Tamoxifen / Q000627:therapeutic use
D013629:Tamoxifen; D013197:Stanozolol; D008535:Megestrol; D019290:Megestrol Acetate