title: Carcinogenicity examination of Agaricus bisporus, edible mushroom, in rats.
abstract: Carcinogenicity of Agaricus bisporus, the edible mushroom, was studied in rats. Female Charles River Sprague - Dawley rats (CD rats) were given a diet containing a 30% dry powder of A. bisporus for 500 days until the termination of the experiment. A control group was given a basal diet without A. bisporus. The rats in the experimental group had mammary tumor, thymoma, adrenal adenoma and pituitary adenoma. However, there was no significant difference in the incidence of these tumors between the experimental group and control group. No carcinogenic activity of A. bisporus was observed in this experiment.
authors.affiliation: Department of Pathology, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Yagyu
authors.forename: H
authors.initials: H
authors.lastname: Ogino
authors.forename: I
authors.initials: I
authors.lastname: Hirono
mesh_terms: D000818:Animals; D001487:Basidiomycota; D001835:Body Weight; D015197:Carcinogenicity Tests; D004032:Diet; D005260:Female; D009145:Mushroom Poisoning / Q000209:etiology*; D009152:Mutagenicity Tests; D009369:Neoplasms / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains