Effect of a terpenoid, (-)-6-hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol, on drug-metabolizing enzymes and glutathione content in rat liver and lung.
1. Chronic treatment of Sprague-Dawley rats with the new terpenoid mucoregulating drug (I) did not modify activities of the drug-metabolizing enzymes (phase I and phase II) of liver and lung. 2. Acute treatment of rats with I did not affect the GSH content of liver and lung, but administration of the corresponding alpha, beta-unsaturated ketone (II) produced considerable GSH depletion in both tissues, the original GSH levels being restored after a few hours. 3. The results are discussed in comparison with those previously obtained with the structurally related drug trans-sobrerol (III).
Lippi
A
A
Istituto di Mutagenesi e Differenziamento, C.N.R., Pisa, Italy.
Gervasi
P G
PG
Bellucci
G
G
Marioni
F
F
Luzzani
F
F
Ventura
P
P
D000818:Animals; D003511:Cyclohexanols / Q000494:pharmacology*; D053138:Cyclohexenes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D007659:Ketones / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology
D003511:Cyclohexanols; D053138:Cyclohexenes; D007659:Ketones; D004364:Pharmaceutical Preparations; D013729:Terpenes; C065237:6-hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol; D003577:Cytochrome P-450 Enzyme System; C003316:sobrerol; D010088:Oxidoreductases; D005978:Glutathione