Osteosarcoma.
Osteosarcoma is principally a disease of the pre-teenager and teenage individual. Pain and swelling of an extremity are the usual initial symptoms. A number of neoplastic and nonneoplastic conditions must be considered in the differential diagnosis. Good quality radiographs complement pathologic material in establishing the diagnosis. Major advances as a consequence of chemotherapy have been achieved during the past decade. Disease-free survival following surgical ablation of the primary tumor and postoperative adjuvant chemotherapy is approximately 60%. The majority of patients undergoing modern forms of treatment are also candidates for limb salvage.
Jaffe
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Department of Pediatrics, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
D000671:Amputation, Surgical; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002985:Clinical Protocols / Q000592:standards; D003663:Decision Trees; D004502:Education, Medical, Continuing; D006801:Humans; D012516:Osteosarcoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D019736:Prostheses and Implants