title: Unfavourable outcome of a patient with M2 acute non lymphocytic leukemia and a 47,XY,t(5;7)(q34;q21), +8 karyotype.
abstract: We report a patient with M2 acute non-lymphocytic leukemia and a complex karyotype: 47,XY,t(5;7)(q34;q21), +8. After chemotherapy with Daunomycin and Arabinosyl Cytosine, a complete remission was reached, but two months later he relapsed and died because of sepsis. Only 5 other cases with translocations involving chromosomes 5 and 7 have been described, but with different breakpoints. Several genes related to cell proliferation and maturation have been identified on the long arms of chromosomes 5 and 7. The possible involvement of specific genes located at or very close to the breakpoints is hypothesized.
authors.affiliation: Centro di Genetica e Citogenetica Oncologica, Istituto di Ematologia L. e A. Seràgnoli, Università di Bologna, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Testoni
authors.forename: A
authors.initials: A
authors.lastname: Zaccaria
authors.forename: B
authors.initials: B
authors.lastname: Celso
authors.forename: S
authors.initials: S
authors.lastname: Tura
mesh_terms: D000293:Adolescent; D000677:Amsacrine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002895:Chromosomes, Human, Pair 5 / Q000378:metabolism; D002897:Chromosomes, Human, Pair 7 / Q000378:metabolism; D002898:Chromosomes, Human, Pair 8 / Q000378:metabolism; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D012074:Remission Induction; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy
chemical_list: D000677:Amsacrine; D003561:Cytarabine; D008942:Mitoxantrone; D003630:Daunorubicin