Computer assisted analysis of hand radiographs in infantile hypophosphatasia carriers.
Hand radiographs of 49 carriers of infantile hypophosphatasia and 67 non-carriers were evaluated using two Apple IIe Computer Programs and an Apple Graphics Tablet. CAMPS (1) was used to determine the bone lengths and calculate the metacarpophalangeal profiles. A newly developed program (ADAM) was used to determine bone density based on percent cortical area of the second metacarpal. Carriers of infantile hypophosphatasia had significantly less dense bones.
Chodirker
B N
BN
Department of Pediatrics and Child Health, University of Manitoba, Canada.
Roy
D
D
Greenberg
C R
CR
Cheang
M
M
Evans
J A
JA
Reed
M H
MH
D000293:Adolescent; D000328:Adult; D015519:Bone Density; D002648:Child; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging; D006580:Genetic Carrier Screening; D006801:Humans; D007014:Hypophosphatasia / Q000000981:diagnostic imaging*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging*; D008838:Microcomputers; D008875:Middle Aged; D011859:Radiography; D012680:Sensitivity and Specificity