[Effect of adaptation to periodic hypoxia on the resistance of the indicators of energy metabolism and myocardial contraction in acute anoxia and reoxygenation].
The effect of preliminary adaptation to intermittent (40 days, 4 hrs daily at 4000 m "altitude") on the resistance of myocardial energy metabolism and contractile function to acute anoxia and subsequent reoxygenation was studied. It was found that adaptation to hypoxia significantly accelerated the restoration of creatine phosphate, ATP and creatine phosphokinase activity in myocardium in reoxygenation following acute anoxia. On the whole, this effect reduces the competition of H+ with Ca2+ in myofibrils to improve the energy supply and to accelerate the restoration of myocardial contractile function in reoxygenation.
Kopylov
Iu N
IuN
Golubeva
L Iu
LIu
D000208:Acute Disease; D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
D010100:Oxygen
Vliianie adaptatsii k periodicheskoĭ gipoksii na ustoĭchivost' pokazateleĭ énergeticheskogo metabolizma i sokratitel'noĭ funktsii miokarda k ostroĭ anoksii i reoksigenatsii.