title: Binding of botulinum type Cl, D and E neurotoxins to neuronal cell lines and synaptosomes.
abstract: Clostridium botulinum 125I-labeled Cl neurotoxin bound to NG108 hybridoma cell line. Unlabeled type Cl neurotoxin inhibited the binding of the labeled Cl toxin but neither types D nor E toxin. 125I-labeled type D neurotoxin bound to rat brain synaptosomes but did not bind to NG108 cells. It is suggested that receptors for types C and D or E toxins on neuronal cell membranes are different.
authors.affiliation: Department of Microbiology, Sapporo Medical College, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yokosawa
authors.forename: K
authors.initials: K
authors.lastname: Tsuzuki
authors.forename: B
authors.initials: B
authors.lastname: Syuto
authors.forename: N
authors.initials: N
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Oguma
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001905:Botulinum Toxins / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D001905:Botulinum Toxins