title: Nuclear gadgets in mitochondrial DNA replication and transcription.
abstract: In mammalian mitochondrial DNA, activation of the light-strand promoter mediates both priming of leading-strand replication and initiation of light-strand transcription. Accurate and efficient transcription requires at least two proteins: mitochondrial RNA polymerase and a separable transcription factor that can function across species boundaries. Subsequently, primer RNAs are cleaved by a site-specific ribonucleoprotein endoribonuclease that recognizes short, highly conserved sequence elements in the RNA substrate.
authors.affiliation: Department of Developmental Biology, Beckman Center, Stanford University School of Medicine 94305-5427.
authors.forename: D A
authors.initials: DA
authors.lastname: Clayton
mesh_terms: D000818:Animals; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D004272:DNA, Mitochondrial; D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases