Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma.
A 22-year-old female with a thymic carcinoma is reported. The tumor was refractory to both chemotherapy and irradiation. The patient died with an aggressive clinical course. Cytogenetic study showed that the tumor cells had a chromosome translocation, t(15;19)(q15;p13), which was not identified previously in human cancer.
Kubonishi
I
I
Department of Medicine, Kochi Medical School, Japan.
Takehara
N
N
Iwata
J
J
Sonobe
H
H
Ohtsuki
Y
Y
Abe
T
T
Miyoshi
I
I
D000328:Adult; D002884:Chromosomes, Human, Pair 15; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007621:Karyotyping; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic