[The effect of an extract from Cochlospermum angolense ("Burututu") on Plasmodium berghei in the mouse malaria suppression test].
Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.
Presber
W
W
Institut für Medizinische Mikrobiologie des Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, BRD.
Herrmann
D K
DK
Hegenscheid
B
B
D000818:Animals; D008288:Malaria / Q000628:therapy*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects*; D014329:Tropical Climate
D010936:Plant Extracts
Wirkung eines Extraktes aus Cochlospermum angolense ("Burututu") auf Plasmodium berghei im Mäusemalaria-Suppressionstest.