[Erythropoiesis and osteogenesis (II. The mechanism of the suppression of erythropoiesis during the reparative process in bone tissue)].
The experiment on rats and mice has shown that the presence of a developing callus in the organism after fracture of the tubular bones inhibits erythropoiesis. Inhibition of erythropoiesis is due to delay of erythropoietin biosynthesis by serotonin. A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells.
Stepanova
N V
NV
Filimonov
V I
VI
D000740:Anemia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D004906:Erythrocyte Count; D004920:Erythropoiesis / Q000502:physiology*; D005596:Fractures, Closed / Q000097:blood / Q000503:physiopathology; D006614:Hindlimb / Q000293:injuries; D006728:Hormones / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA; D010012:Osteogenesis / Q000502:physiology*; D010659:Phenylhydrazines; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006728:Hormones; D010659:Phenylhydrazines; C030299:phenylhydrazine
Eritropoéz i osteogenez (II. Mekhanizm ugneteniia éritropoéza pri reparativnom protsesse v kostnoĭ tkani).