title: [Biological indicators of bacterial infection in newborn infants].
abstract: Biological markers of neonatal bacterial infection are useful if they bring early indications and if they are sensitive and specific. There are two kinds of tests: hematological signs and acute phase proteins. The most specific hematological signs are, in chronological order: leuconeutropenia--myelemia--neutrophilic polynucleosis. Gestational and post-natal ages have to be taken in consideration for correct interpretation of white cell count and differential. Several acute phase proteins increase in infected newborns: fibrinogen, C reactive protein, orosomucoïd. If determined quantitatively, C reactive protein is a sensitive, specific and early marker allowing, in addition, to follow the reaction to treatment: the return to normal range of CRP and later of orosomucoïd attest for recovery. These biological tests have to be sequentially determined during the first days in order to obtain a maximal information.
authors.affiliation: hôpital de Hautepierre, CHU de Strasbourg.
authors.forename: J
authors.initials: J
authors.lastname: Messer
authors.forename: L
authors.initials: L
authors.lastname: Donato
authors.forename: R
authors.initials: R
authors.lastname: Casanova
authors.forename: D
authors.initials: D
authors.lastname: Willard
mesh_terms: D000375:Aging / Q000097:blood / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D015415:Biomarkers / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood
chemical_list: D015415:Biomarkers
vernacular_title: Les indicateurs biologiques d'infection bactérienne chez le nouveau-né.