Methanesulfonyl fluoride enhances one-trial reward learning in mid-aged rats.
In previous studies, 18-month-old rats have shown no significant retention 24 hours after the single acquisition trial in a one-trial discriminative reward learning task. In the present study, ten 18-month-old rats pretreated with 0.5 mg/kg MSF IP showed significantly better retention in terms of speed and errors than eleven 18-month-old rats pretreated with injection vehicle alone. However, twelve two-three-month-old rats pretreated with the same dose of MSF failed to show better retention than eleven two-three-month-old rats pretreated with vehicle alone.
Malin
D H
DH
Program in Behavioral Science, University of Houston-Clear Lake, TX 77058.
Toups
P J
PJ
Osgood
L D
LD
Fowler
D E
DE
Hunter
C L
CL
Arcangeli
K R
KR
Moss
D E
DE
D000375:Aging / Q000523:psychology; D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D013268:Stimulation, Chemical; D013450:Sulfones / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D013450:Sulfones; C005109:methanesulfonyl fluoride; D002802:Cholinesterases