Age influence on mononuclear phagocyte system Fc-receptor function in poststreptococcal nephritis.
The Fc-receptor function of the mononuclear phagocyte system (MPS) was examined in 41 children and adult patients, by measuring the clearance of IgG-sensitized, 51Cr-labeled erythrocytes. The Fc-receptor-mediated clearance observed in patients (mean +/- SE) was not significantly different as compared to the control group of similar age distribution. However, the immune clearance time was significantly age-correlated in both groups (acute poststreptococcal glomerulonephritis, APSGN, r = 0.39, p less than 0.05; control r = 0.63, p less than 0.01). The magnitude of the Fc-specific immune clearance and the serum creatinine were also significantly correlated (r = 0.59; p less than 0.01). Circulating immune complexes (as measured by the C1q and conglutinin ELISA) did not correlate with immune clearance, which remained stable in longitudinal studies. Age-related changes in MPS Fc-receptor function could explain, at least in part, prognostic differences between children and adult patients with APSGN.
Mezzano
S
S
Division of Nephrology, School of Medicine, Universidad Austral, Valdivia, Chile.
Lopez
M I
MI
Olavarria
F
F
Ardiles
L
L
Arriagada
A
A
Elgueta
S
S
Wegman
M E
ME
Fuentes
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002648:Child; D002860:Chromium Radioisotopes; D003401:Creatine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000382:microbiology / Q000503:physiopathology*; D006648:Histocompatibility; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D010586:Phagocytes / Q000502:physiology / Q000648:ultrastructure*; D011961:Receptors, Fc / Q000502:physiology*; D013154:Spleen / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure; D013290:Streptococcal Infections / Q000150:complications / Q000503:physiopathology*
D002860:Chromium Radioisotopes; D011961:Receptors, Fc; D003401:Creatine