title: Serum bupivacaine concentrations following wound infiltration in children undergoing inguinal herniotomy.
abstract: Serum bupivacaine concentrations were measured in 12 children who underwent elective herniotomy and who received analgesia in the form of wound infiltration. Mean (SD) peak concentration was 0.36 (0.14) micrograms/ml and time to peak concentration was 14.6 (7.2) minutes after infiltration of 1.25 mg/kg of bupivacaine. These concentrations are lower than those associated with other local anaesthetic blocks and well below potentially toxic levels. Wound infiltration provides a simple, effective and safe method of providing postoperative analgesia for hernia repair in children.
authors.affiliation: Department of Anaesthesia, Leicester Royal Infirmary.
authors.forename: K A
authors.initials: KA
authors.lastname: Mobley
authors.forename: J G
authors.initials: JG
authors.lastname: Wandless
authors.forename: D
authors.initials: D
authors.lastname: Fell
mesh_terms: D000698:Analgesia / Q000379:methods*; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D007267:Injections; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D002045:Bupivacaine