The 3-7 fragment of angiotensin II is probably responsible for its psychoactive properties.
The abilities of angiotensin II-(3-7)-pentapeptide (A-II-(3-7), 1 nmol) and angiotensin II (A-II, 1 nmol) to influence rat's psychomotor and cognitive behaviours were compared. Both peptides, given intracerebroventricularly (i.c.v.), 15 min before the experiment, increased number of crossings, rearings and bar approaches in the open field. A-II-(3-7) as well as A-II, at the same doses and routes, significantly intensified stereotypy produced by apomorphine (1 mg/kg) and amphetamine (6.5 mg/kg), both given intraperitoneally. The 3-7 fragment of A-II and A-II in equimolar doses (1 nmol, i.c.v.) were similarly effective in improving learning of conditioned avoidance responses and recall of a passive avoidance behaviour. Taken together, these data and our previous findings indicate that, in rats, the 3-7 fragment of A-II is responsible for the psychoactive properties of angiotensins.
Braszko
J J
JJ
Department of Pharmacology, Medical Academy, Białystok, Poland.
Własienko
J
J
Koziołkiewicz
W
W
Janecka
A
A
Wiśniewski
K
K
D000704:Analysis of Variance; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D003213:Conditioning, Psychological; D008297:Male; D008568:Memory / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D010446:Peptide Fragments; D011619:Psychotropic Drugs; D000804:Angiotensin II; C069545:angiotensin II (3-7); D001058:Apomorphine