Response of Ehrlich carcinoma and the small intestine of mouse to combined treatment with chlorpromazine and X-rays.
The effect of combined treatment with chlorpromazine (20 mg/kg body weight) and X-rays at different dose levels was tested on the growth of Ehrlich carcinoma tumor in solid or ascites form in mice. The radiation response of murine gut was also examined separately but under similar experimental conditions. The results obtained indicate that chlorpromazine did not influence the radiation response of all the test systems used in this study. The relevant literature, reviewed in short, shows that the interaction between chlorpromazine and X-rays can result in enhanced radiation response, non-interference or increased radiation tolerance. Therefore any combined effect of chlorpromazine and X-rays observed cannot be generalised.
Rao
K R
KR
Radiobiological Institute of Zurich University, Switzerland.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000532:radiotherapy*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002746:Chlorpromazine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007414:Intestinal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D007421:Intestine, Small / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D011836:Radiation Tolerance / Q000187:drug effects; D011879:Radiotherapy Dosage
D002746:Chlorpromazine