[Production of interleukin-1 by peripheral blood monocytes in children with respiratory diseases].
Overall 111 healthy children aged 3 to 7 years, 71 children with ARVI and those aged 2 to 14 years with ARVI complicated by bronchitis and pneumonia were examined. The level and rate of IL-1 production by peripheral blood monocytes in response to lipopolysaccharide (LPS) were determined. It has been established that 98.7% of the healthy children responded to LPS by marked production of IL-1. In 3 children, there was po synthesis of IL-1, in 26.1% of the healthy children, peripheral blood monocytes produced IL-1 without addition of LPS. In children with respiratory bacterial infections, there was a significant increase of IL-1 production as compared to the control. IL-1 production in ARVI was lowered.
Konusova
V G
VG
Simbirtsev
A S
AS
Ketlinskiĭ
S A
SA
Annamuradov
D O
DO
Iur'ev
V V
VV
D000293:Adolescent; D001991:Bronchitis / Q000097:blood; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D011014:Pneumonia / Q000097:blood; D012141:Respiratory Tract Infections / Q000097:blood*
D007375:Interleukin-1
Produktsiia interleĭkina-1 monotsitami perifericheskoĭ krovi u deteĭ s respiratornymi zabolevaniiami.