Effect of pancreatic secretions upon ileal disaccharidase activities of neonatal miniature pigs.
Mechanisms by which pancreatic secretions influence disaccharidase activities in the distal small intestine have been investigated in 1-week-old miniature pigs. Using a combination of biochemical, cytochemical and morphological techniques it has been found that the decrease in lactase specific activity is due solely to a reduction in villus surface area. By contrast, the increased sucrase-isomaltase activities, which occur despite the reduction in villus surface area, are due entirely to increased enzyme expression during enterocyte differentiation.
Tivey
D R
DR
AFRC Institute of Animal Physiology & Genetics Research, Babraham, Cambridge, England.
Shulman
R J
RJ
D000818:Animals; D000831:Animals, Newborn; D004186:Disaccharidases / Q000378:metabolism*; D007082:Ileum / Q000201:enzymology*; D008026:Ligation; D010179:Pancreas / Q000378:metabolism* / Q000601:surgery; D013270:Stomach / Q000201:enzymology; D013394:Sucrase-Isomaltase Complex / Q000378:metabolism; D013552:Swine; D013556:Swine, Miniature
D004186:Disaccharidases; D013394:Sucrase-Isomaltase Complex