Synthesis, characterization, and in vitro cytotoxic effects of K4 [PtCl2ATP].
An antineoplastic agent, cis-K4 [PtCl2ATP] has been synthesized and characterized, using elemental analysis, solution conductance, thermoanalysis, infrared, NMR spectroscopy, and circular dichroism studies. The in vitro cytotoxic effect imparted by this compound on Dalton's Lymphoma cells has been assessed by Trypan blue dye exclusion method and 51Cr release assays.
Nayak
K K
KK
Department of Chemistry, Jadavpur University Calcutta, India.
Bhattacharyya
R
R
Maity
P
P
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002860:Chromium Radioisotopes; D004354:Drug Screening Assays, Antitumor; D008223:Lymphoma / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014343:Trypan Blue; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002860:Chromium Radioisotopes; D009944:Organoplatinum Compounds; C069451:platinum dichloride-adenosine triphosphate complex; D000255:Adenosine Triphosphate; D014343:Trypan Blue