Transcription of ribosomal DNA intergenic spacer sequences in normal and regenerating rat liver.
In regenerating rat liver both the transcriptional activity of the intergenic spacer rDNA promoter and the steady-state abundance of spacer transcripts are increased about 2-fold, as compared to normal liver. These changes are parallel to the observed 2.5-fold increase in regenerating liver of rRNA gene promotor activity and gene promotor transcripts abundance. These results suggest that both gene and spacer rDNA promotors are subject to common regulatory mechanisms. Our results indicate also that the stability of spacer transcripts in regenerating liver is not significantly altered.
Kalcheva
I D
ID
Institute of Cell Biology and Morphology, Bulgarian Academy of Sciences, Sofia.
Karagyozov
L K
LK
Hadjiolov
A A
AA
D000818:Animals; D004275:DNA, Ribosomal / Q000235:genetics*; D008115:Liver Regeneration; D008297:Male; D010957:Plasmids; D011401:Promoter Regions, Genetic; D012335:RNA, Ribosomal / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D015183:Restriction Mapping; D014158:Transcription, Genetic
D004275:DNA, Ribosomal; D012335:RNA, Ribosomal