[Pro34]neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs.
Anaesthetised rats and dogs were used to study the pre- and postjunctional actions of neuropeptide Y (NPY) and [Pro34]NPY simultaneously. Increases in arterial blood pressure indicated postjunctional actions and both NPY and [Pro34]NPY elicited these. Change in pulse interval evoked by stimulation of the cut peripheral end of the right vagus nerve, indicated prejunctional action of the peptides: NPY caused prolonged attenuation of vagal action in rats and dogs but [Pro34]NPY did not attenuate vagal action in rats or dogs.
Potter
E K
EK
School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
Fuhlendorff
J
J
Schwartz
T W
TW
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005071:Evoked Potentials / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006801:Humans; D009469:Neuromuscular Junction / Q000187:drug effects*; D009478:Neuropeptide Y / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013552:Swine
D009478:Neuropeptide Y; C069401:neuropeptide Y, Pro(34)-