Genetics of major psychiatric disorders.
We review recent studies on the inheritance of affective disorders and schizophrenia. Both groups of diseases have substantial genetic and non-genetic components, and their inheritance does not fit simple Mendelian models. Linkage studies implicate the Xp28 and 11p15 regions as potential disease loci in affective illness, and the 5q11-q13 region in schizophrenia. These conclusions are highly controversial, however, and must be viewed as extremely tentative.
Ciaranello
R D
RD
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305.
Ciaranello
A L
AL
D008040:Genetic Linkage; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D019964:Mood Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics