The fifth nonlethal case of primary amoebic meningoencephalitis.
The fifth nonlethal case of primary amoebic meningoencephalitis was reported. He was a 61-year-old gardener from northeast Thailand who had an abrupt onset of high fever, headache and stupor. Lumbar puncture showed numerous naegleria in the cerebrospinal fluid. The combination of 0.5 mg/kg/day of intravenous amphotericin B for 14 days, oral rifampicin and oral ketoconazole for 1 month cured the patient with no recurrence after one year of follow-up. The authors emphasise the regimen of low dose amphotericin B for a prolonged period instead of a high dose over a short period.
Poungvarin
N
N
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jariya
P
P
D000562:Amebiasis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000401:mortality; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D009253:Naegleria; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology
D000666:Amphotericin B