title: Endocrine and dermatological concomitants of mental stress.
abstract: The role of psychosocial stress in the etiology and clinical course of psoriasis and atopic dermatitis still remains to be elucidated. In this study, we assessed neuroendocrine, dermatological, and cognitive responses in healthy subjects and in subjects suffering from psoriasis and atopic dermatitis, respectively. Perceived stress increased the most in psoriatics during the stressor exposure but tended to return faster to baseline in this group than was found for atopics and healthy controls. Growth hormone secretion was attenuated during stress in patients with skin disorders. Overall, neuroendocrine reactivity was similar in the three groups. Dermal flare reactivity was enhanced in healthy controls but perceived itch enhanced in atopics in response to stress. Stress per se was not an important discriminator between groups. Coping style and other cognitive factors turned out to be of significant importance to predict skin reactivity rather than a specific skin disease. The study suggests that psychosocial stress affects the skin reactivity and that cognitive factors modulate such effects. However, a specific skin condition explains only a fraction of the overall variance in skin reactivity to specific stressors.
authors.affiliation: Department for Stress Research, Karolinska Institute, Stockholm, Sweden.
authors.forename: B B
authors.initials: BB
authors.lastname: Arnetz
authors.forename: B
authors.initials: B
authors.lastname: Fjellner
authors.forename: P
authors.initials: P
authors.lastname: Eneroth
authors.forename: A
authors.initials: A
authors.lastname: Kallner
mesh_terms: D003876:Dermatitis, Atopic / Q000097:blood / Q000473:pathology / Q000523:psychology*; D013006:Growth Hormone / Q000097:blood*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D010555:Personality Inventory; D011565:Psoriasis / Q000097:blood / Q000473:pathology / Q000523:psychology*; D012867:Skin / Q000187:drug effects; D013315:Stress, Psychological / Q000150:complications*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D013006:Growth Hormone