[DNA repair in peripheral blood lymphocytes of cancer patients].
Blood lymphocyte ability for DNA reparation in response to injuring DNA test-exposure of x-radiation in vitro at a dose 250 Gy was investigated in 158 patients with breast and genital tumors and 40 donors. Suppression of the DNA reparative synthesis before a regular course of cancer therapy (which did not depend on a nosological entity, type and number of cancer therapy courses) was noted in 61% of the patients. However the frequency of such patients was significantly increased with regard to tumor spreading. Individual differences in the ability of cancer patients' lymphocytes for reparation before therapy can reflect, to a certain extent, their function and serve as an additional criterion for predicting complications of cancer therapy.
Nikiforova
N A
NA
Moskalenko
I P
IP
Gaĭseniuk
L A
LA
Pozhidaeva
O N
ON
D000328:Adult; D001943:Breast Neoplasms / Q000097:blood* / Q000628:therapy; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D003131:Combined Modality Therapy; D004247:DNA / Q000097:blood* / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000628:therapy; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D008875:Middle Aged; D014680:Veins
D004247:DNA
Reparatsiia DNK limfotsitov perifericheskoĭ krovi onkologicheskikh bol'nykh.