title: Cellular electrophysiology of neonatal and adult rabbit atrioventricular node.
abstract: Adult and neonatal rabbit atrioventricular node (AVN) preparations were studied using transmembrane and surface electrogram recordings. Action potentials were categorized into four types, atrionodal (AN), nodal (N), "high" nodo-His (NH) (HNH), and "low" NH (LNH), according to their action potential characteristics and their location within the A-H interval. The electrophysiological parameters of the lower three regions were identical between the two age groups. Action potentials from the neonatal AN region were lower in amplitude and maximum diastolic potential than they were in the adult. The N cell action potential parameters did not differ between the two age groups, however, there did appear to be qualitative differences. AVN conduction times (A-H intervals) were the same in both age groups, as were the antegrade and retrograde refractory periods, and the Wenckebach intervals. Pacemaker activity was significantly greater in the neonates than in the adults and, in 11 of 13 neonatal preparations, originated in the AN region or higher. In 13 of 14 adult preparations, pacemaker activity resided within the AVN.
authors.affiliation: Medical University of South Carolina, South Carolina's Children's Heart Center, Charleston 29425.
authors.forename: K W
authors.initials: KW
authors.lastname: Hewett
authors.forename: C H
authors.initials: CH
authors.lastname: Gaymes
authors.forename: C I
authors.initials: CI
authors.lastname: Noh
authors.forename: B A
authors.initials: BA
authors.lastname: Ross
authors.forename: R P
authors.initials: RP
authors.lastname: Thompson
authors.forename: D S
authors.initials: DS
authors.lastname: Buckles
authors.forename: P C
authors.initials: PC
authors.lastname: Gillette
mesh_terms: D000200:Action Potentials; D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001283:Atrioventricular Node / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D004594:Electrophysiology; D009431:Neural Conduction; D011817:Rabbits; D012032:Refractory Period, Electrophysiological; D013997:Time Factors