Towards an integrated view of thymopoiesis.
One prediction from the complex series of steps in intrathymic T-cell differentiation is that to regulate it the stroma controlling the process must be equally complex: the attraction of precursors, commitment to the T-cell lineage, induction of T-cell receptor (TCR) gene rearrangement, accessory molecule expression, repertoire expansion, major histocompatibility complex (MHC) molecule-based selection (positive and negative), acquisition of functional maturity and migratory capacity must all be controlled. In this review, Richard Boyd and Patrice Hugo combine knowledge of T-cell differentiation with thymic stromal cell heterogeneity to offer an integrated view of thymopoiesis within the thymic microenvironment.
Boyd
R L
RL
Dept of Pathology and Immunology, Monash Medical School, Prahran, Australia.
Hugo
P
P
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis; D015415:Biomarkers; D002454:Cell Differentiation; D002465:Cell Movement; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D051379:Mice; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D011948:Receptors, Antigen, T-Cell