Dystonia and akinesia due to pallidoputaminal lesions after disulfiram intoxication.
A case with segmental cranial plus crural dystonia of delayed onset and akinesia after acute intoxication with disulfiram is presented. Computed tomography showed bilateral pallidal lesions, whereas on magnetic resonance imaging additional small lesions of the putamen could be detected. Long-term observation with progression and a change of symptoms over a period of 10 years after the intoxication is demonstrated on videotape. Although other central side effects after intoxication with disulfiram are well known, movement disorders are uncommon. Carbon disulfide, a disulfiram metabolite, may be important in the etiopathogenesis.
Krauss
J K
JK
Department of Neurosurgery, Albert-Ludwigs-Universität, Freiburg, Germany.
Mohadjer
M
M
Wakhloo
A K
AK
Mundinger
F
F
D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation; D004221:Disulfiram / Q000506:poisoning* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000473:pathology*; D004409:Dyskinesia, Drug-Induced / Q000473:pathology*; D004421:Dystonia / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D011699:Putamen / Q000187:drug effects* / Q000473:pathology; D013406:Suicide, Attempted; D014057:Tomography, X-Ray Computed
D004221:Disulfiram