Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome.
We have isolated a novel human zinc finger gene, ZNF41, from a human X-chromosome-specific library. Nucleotide sequence analysis reveals that ZNF41 potentially encodes a polypeptide featuring an array of 18 contiguous zinc fingers of the C2H2 type. Multiple polyadenylated transcripts homologous to ZNF41 are present at different levels in several distinct cell types. Southern analyses of somatic cell hybrids containing either intact or rearranged X chromosomes confirm the genomic origin of the isolated gene and establish that it is localized between Xcen and Xp22.1.
Franzè
A
A
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Archidiacono
N
N
Rocchi
M
M
Marino
M
M
Grimaldi
G
G
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA; D005260:Female; D015870:Gene Expression; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D016415:Sequence Alignment; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D014960:X Chromosome; D016335:Zinc Fingers / Q000235:genetics*
D004247:DNA