title: The hippocampal tissue slice in animal models of CNS disorders.
abstract: The use of in vitro brain slice preparations has increased in the past ten years, particularly the hippocampal slice because of the dissection ease, well-defined cell layers, and self-contained afferent systems. Developing the slice as a model for screening neurotoxins is of particular interest because of the sensitivity of hippocampal neurons to chemical or metabolic insult and the need to keep animal usage to a minimum. Experiments where the slice has been used to study the neurotoxin trimethyltin are discussed, along with its use as a model for investigating the neurodegenerative problems associated with hypoxia, ischemia, and epilepsy.
authors.affiliation: Division of Life Sciences, University of Texas, San Antonio 78285.
authors.forename: D L
authors.initials: DL
authors.lastname: Armstrong
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques