[Biomolecular aspects of adult T-cell leukemia].
ATL (adult T-cell leukemia) is the first human cancer known to be caused by a retrovirus. ATL cells show usually positive for CD2, CD3, CD4, CD25 and HLA-DR, but negative for CD8. They produce a variety of cytokines, including IL-1, IL-2, TNF, ADF and PTHrP. PTHrP is considered to be responsible for hypercalcemia which is frequently observed in ATL. Recently, we reported two unusual cases of HTLV-I associated malignancy; 1) a case of CD4 and 8 double negative tumor affecting mainly gastrointestinal tract and 2) a case mimicking small cell lung cancer. IL-2-toxin, a conjugate of IL-2 and diphtheria toxin, has been prepared as a recombinant product and evaluated for the suppressive effect to ATL cells. Clinical trail of IL-2-toxin is now anticipated.
Takatsuki
K
K
Second Dept. of Internal Medicine, Kumamoto University Medical School.
Hattori
T
T
Yamaguchi
K
K
Matsuzaki
H
H
Asou
N
N
Kiyokawa
T
T
Maeda
Y
Y
Suzushima
H
H
D015703:Antigens, CD / Q000378:metabolism; D004167:Diphtheria Toxin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D000922:Immunotoxins / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism
D015703:Antigens, CD; D004167:Diphtheria Toxin; D000922:Immunotoxins; D007376:Interleukin-2; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins