[Chronotherapy of tenoxicam].
A study was carried out in order to investigate the chronotherapy (dosing time dependency) of an NSAID, the tenoxicam administered in ankylosing spondylitis, rheumatoid arthritis and osteoarthritis of the hip. These variations in efficacy exist as much for pain as for stiffness and maximum efficacy is obtained with administration at 8 am or 12 pm. Since the tolerance was good, we recommend midday as an optimal once-a-day dosing time.
Reinberg
A
A
Fondation A. de Rothschild, CNRS, URA 581, Paris.
Manfredi
R
R
Kahn
M F
MF
Chaouat
D
D
Chaouat
Y
Y
Delcambre
B
B
Le Goff
P
P
Maugars
Y
Y
Valat
J P
JP
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000188:drug therapy; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C032801:tenoxicam
Chronothérapie du ténoxicam.