Lead given systemically to mice in experimental delay of implantation increases the oxygen consumption of delayed blastocysts.
The metabolic activity of pre-implantation blastocysts recovered from delayed mice before and after administration of lead was estimated by measuring their oxygen consumption using a spectrophotometer technique. Normal blastocysts, activated for implantation, increased their oxygen consumption by about 50% compared with inactive, delayed blastocysts. Inactive, delayed blastocysts from lead-injected mice reached the same level of oxygen consumption even without oestrogen administration. Oestrogen given to the lead-injected mice did not further increase the oxygen consumption of their blastocysts. It is concluded that administration of lead to pre-implantation mice resulted in increased metabolic activity of their blastocysts due either to a direct effect of lead or to an indirect effect, caused by changed composition of the uterine secretion.
Nilsson
B O
BO
Department of Human Anatomy, Biomedical Centre, Uppsala, Sweden.
Einarsson
B
B
Magnusson
C
C
D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000378:metabolism*; D010065:Embryo Implantation, Delayed / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D010101:Oxygen Consumption / Q000187:drug effects*; D011247:Pregnancy; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D007854:Lead