[Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil].
Two patients with psoriasis vulgaris who travelled to endemic malaria areas developed erythroderma and generalized psoriasis guttata 3-4 weeks after starting prophylactic antimalarial medication with chloroquine/proguanil. The lesions resolved after 3 months of intensive treatment and discontinuation of the antimalarial drugs. The literature on these less known adverse effects of antimalarials in psoriatic patients is reviewed. Because of the severity of a malaria infection we advise psoriasis patients to have adequate malaria prophylaxis.
Damstra
R J
RJ
Academisch Ziekenhuis, afd. Dermatologie en Venereologie, Utrecht.
van Vloten
W A
WA
D002738:Chloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D002727:Proguanil / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000139:chemically induced* / Q000188:drug therapy
D002738:Chloroquine; D002727:Proguanil
Exacerbatie van psoriasis door malariaprofylaxe met chloroquine en proguanil.