title: [Metabolic disorders and their correction in schoolchildren with different forms of caries].
abstract: Biochemical studies of salivary metabolic disorders in 839 schoolchildren with various forms of caries have revealed salivary pH range to vary from 6.23 +/- 0.02 to 6.80 +/- 0.04, with calcium and inorganic phosphorus levels varying from 4.20 +/- 0.07 to 5.12 +/- 0.11 mg% and from 0.117 +/- 0.05 to 1.041 +/- 0.21 micrograms/ml, respectively. Alkaline phosphatase activity range was found to vary from 107.7 +/- 7.65 to 295.0 +/- 32.3, that of acids from 11.7 +/- 1.81 to 52.5 +/- 4.61 nmol/ml. alpha-ketoglutarate, oxalacetate, phosphoenolpyruvate levels were 3.12 +/- 0.03 to 28.8 +/- 3.41 mumol/ml, fructose diphosphatase content from 2.5 +/- 0.35 to 8.71 +/- 0.72 nmol/s/ml. Use of namacit various dosage forms (5 percent aqueous solution, as a toothpaste component--6 percent, or a component of an adhesive coating) elevated salivary pH level to 7.06. Calcium level remained unchanged, that of inorganic phosphorus increased (p less than 0.001), phosphatase activities grew, as did acid levels and fructose diphosphatase activity, that increased irrespective of the dosage form used (p less than 0.001).
authors.forename: M M
authors.initials: MM
authors.lastname: Rudenko
mesh_terms: D000293:Adolescent; D002327:Cariostatic Agents / Q000008:administration & dosage; D002648:Child; D003487:Cyanoacrylates / Q000008:administration & dosage; D003731:Dental Caries / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005943:Gluconeogenesis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009824:Ointments; D009930:Organic Chemicals; D010895:Pit and Fissure Sealants / Q000008:administration & dosage; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012996:Solutions
chemical_list: D002327:Cariostatic Agents; D003487:Cyanoacrylates; D009824:Ointments; D009930:Organic Chemicals; D010895:Pit and Fissure Sealants; D012996:Solutions; C069548:namatsit; C007166:cyacrin
vernacular_title: Metabolicheskie narusheniia i ikh korrektsiia u shkol'nikov s razlichnymi formami kariesa.