title: Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs.
abstract: Gastric administration of encapsuled garlic powder to anaesthetized dogs induced dose-dependent (2.5 to 15 mg/kg) natriuretic and diuretic responses which reached maximum 30-40 min after garlic administration and decreased to basal levels after 100-150 min. A simultaneous decrease in arterial blood pressure was observed which continued past the 250 min-mark. High garlic doses (15 and 20 mg/kg) provoked bradycardia and T-wave inversion during the first 10-15 min of the experiment with recordings returning to normal and staying normal throughout the remainder of the experiment.
authors.affiliation: Department of Physiology, Faculty of Biological and Natural Sciences, Universidad de Concepción, Chile.
authors.forename: C V
authors.initials: CV
authors.lastname: Pantoja
authors.forename: L C
authors.initials: LC
authors.lastname: Chiang
authors.forename: B C
authors.initials: BC
authors.lastname: Norris
authors.forename: J B
authors.initials: JB
authors.lastname: Concha
mesh_terms: D000758:Anesthesia; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D005737:Garlic; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010946:Plants, Medicinal
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics