Approaches to immunotoxicologic studies with emphasis on chemical-induced immunomodulation.
Immunotoxicology has developed into a subdiscipline of toxicology in a tradition similar to other subdisciplines of toxicology. The use of experimental animals to determine the potential for chemicals to alter the structure and function of the immune system represents a significant part of this subdiscipline. This manuscript describes approaches to assessment of chemical-induced modification of immune status and key issues in interpreting the data for risk assessment.
Munson
A E
AE
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia.
McCay
J A
JA
Cao
W
W
D000818:Animals; D000937:Antigen-Antibody Reactions; D004785:Environmental Pollutants / Q000009:adverse effects / Q000633:toxicity*; D004787:Environmental Pollution / Q000009:adverse effects; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007154:Immune System Diseases / Q000139:chemically induced / Q000175:diagnosis
D004785:Environmental Pollutants