The pharmacokinetics of postoperative intravenous ketorolac tromethamine in children.
Ketorolac tromethamine (0.5 mg kg-1) was given intravenously to 10 children (age 4-8 years) after minor surgery. Values of steady-state volume of distribution and plasma clearance were approximately two times higher than those in adults but values of elimination half-life were similar.
Olkkola
K T
KT
Department of Clinical Pharmacology, University of Helsinki, Finland.
Maunuksela
E L
EL
D000758:Anesthesia; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D020911:Ketorolac Tromethamine; D008297:Male; D011184:Postoperative Period; D011229:Preanesthetic Medication; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014325:Tromethamine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004338:Drug Combinations; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin