[Treatment of human superficial tumors by ionizing radiation combined with ultrasound].
Short-term treatment (3 minutes) with low intensity (1.8 w/cm2) ultrasound was applied to human tumors in combined treatment with ionizing radiation. Tumor regression was observed with the dose below TDF (time dose fractionation) 40, and 50% reduction in tumor masses was observed at doses with TDF 45 to 62, and the mean dose was TDF 52. Complete remission of tumor masses was recognized with doses of TDF 62 to 113 in 9 of 10 treated lesions. Five cases, with multiple lesions, were treated with controlled ionizing radiation without ultrasound. Fifty percent reduction in tumor masses was observed with doses of TDF 74 to 113, and the mean dose was TDF 86. Complete remission of tumor mass was not observed. Radioenhancement ratio by ultrasound was 1.6 for 50% tumor reduction. Skin temperature was elevated to about 3 degrees C as measured by thermography, but intradermal temperature was not apparently elevated. Ultrasound potentiates the effects of localized radiotherapy not due to hyperthermia but to the other factors.
Kobayashi
H
H
Division of Radiology, Gifu Prefectural Tajimi Hospital.
Sakuma
S
S
D001943:Breast Neoplasms / Q000532:radiotherapy / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D012878:Skin Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D014464:Ultrasonic Therapy