[The effect of adrenaline on the succinate dehydrogenase activity in functionally changed (lymphoid leukosis) lymphocytes in mice].
The activity of succinate dehydrogenase (SDH) in lymphocytes of peripheral blood of AKR mice was measured in response to intraperitoneal injection of epinephrine hydrochloride at a dose of 1 mg/kg. SDH reactions to epinephrine were of two types: increase or decrease of activity. The type of reaction depended on the initial enzyme level. The decrease of epinephrine activation of SDH in lymphocytes was found to be correlated with the age of animals and hematological manifestations of hemoblastosis they developed. The percentage of cells with a high SDH activity in hemoblastotic animals was correlated with the count of prolymphocytes and blast cells in peripheral blood.
Davydov
B I
BI
Gaĭdamakin
A N
AN
L'vova
T S
TS
Romaniuk
N N
NN
D000818:Animals; D003864:Depression, Chemical; D004837:Epinephrine / Q000494:pharmacology*; D007945:Leukemia, Lymphoid / Q000201:enzymology* / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008806:Mice, Inbred AKR; D013268:Stimulation, Chemical; D013385:Succinate Dehydrogenase / Q000097:blood*
D013385:Succinate Dehydrogenase; D004837:Epinephrine
Vliianie adrenalina na aktivnost' suktsinatdegidrogenazy v funktsional'no izmenennykh (limfoleĭkoznykh) limfotsitakh krovi mysheĭ.