Interaction of prostaglandin E1 with alpha-cyclodextrin in aqueous systems: stability of the inclusion complex.
Prostavasin, an inclusion complex of prostaglandin E1 (PGE1) with alpha-cyclodextrin (alpha-CD), is used in the therapy of thrombosis. Nuclear magnetic resonance measurements have been made to study the interaction of PGE1 with alpha-CD. The observed interaction (chemical shift) and the derived dissociation constant prove that only weak interaction forces are operative and that complete dissociation occurs upon dilution.
Wiese
M
M
Institute for Experimental Biology and Medicine, Borstel, FRG.
Cordes
H P
HP
Chi
H
H
Seydel
J K
JK
Backensfeld
T
T
Müller
B W
BW
D000527:Alprostadil / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009994:Osmolar Concentration; D012996:Solutions; D013816:Thermodynamics; D047391:alpha-Cyclodextrins
D003505:Cyclodextrins; D012996:Solutions; D047391:alpha-Cyclodextrins; D000527:Alprostadil; C032613:alpha-cyclodextrin