title: Reduction in sella turcica volume. An effect of long-term treatment with the somatostatin analogue, SMS 201-995, in acromegalic patients.
abstract: Ten patients with acromegaly were treated with the long-acting somatostatin analogue, Sandostatin (SMS 201-995, octreotide) for more than one year. Computerized tomography was performed before and on 4 different occasions during the treatment. Sella turcica volumes were calculated in nine patients and showed a gradual decrease in all, averaging 32% +/- 14.6%, P less than 0.001 at the end of the study, which is probably indicative of a simultaneous reduction in adenoma size.
authors.affiliation: Diagnostic Radiology Department, Aarhus Kommunehospital, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Lund
authors.forename: J
authors.initials: J
authors.lastname: Jørgensen
authors.forename: S E
authors.initials: SE
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Weeke
authors.forename: H
authors.initials: H
authors.lastname: Orskov
authors.forename: A G
authors.initials: AG
authors.lastname: Harris
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D012658:Sella Turcica / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D013006:Growth Hormone; D015282:Octreotide