title: Restricticin, a novel glycine-containing antifungal agent.
abstract: Restricticin (1) is a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities and is unrelated to any previously known family of natural products. This unstable compound, as well as its corresponding N,N-dimethyl derivative (2), have been produced and isolated from both solid and liquid fermentations of Penicillium restrictum. The desglycyl hydrolysis product, restrictinol (3), was produced via the hydrolysis of pure restricticin and as an artifact of the isolation of restricticin.
authors.affiliation: Merck, Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
authors.forename: R E
authors.initials: RE
authors.lastname: Schwartz
authors.forename: C
authors.initials: C
authors.lastname: Dufresne
authors.forename: J E
authors.initials: JE
authors.lastname: Flor
authors.forename: A J
authors.initials: AJ
authors.lastname: Kempf
authors.forename: K E
authors.initials: KE
authors.lastname: Wilson
authors.forename: T
authors.initials: T
authors.lastname: Lam
authors.forename: J
authors.initials: J
authors.lastname: Onishi
authors.forename: J
authors.initials: J
authors.lastname: Milligan
authors.forename: R A
authors.initials: RA
authors.lastname: Fromtling
authors.forename: G K
authors.initials: GK
authors.lastname: Abruzzo
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004355:Drug Stability; D005285:Fermentation; D005998:Glycine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000032:analysis / Q000378:metabolism; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D011714:Pyrans; C069635:restricticin; D005998:Glycine