[Antioxidant protective system under high altitude conditions].
Experiments were conducted on 300 unbred male albino rats (weighing 150-200 g) under conditions of foothill plains (Frunze, 760 m above sea level) and the highlands (3,200 m above sea level) to study the antioxidant (AO) defence properties of the following enzymes: superoxide dismutase, catalase, glutathione peroxidase, as well as the low-molecular antioxidant glutathione. The activity of the defence enzymes and glutathione is marked by a complex dynamic, cyclic character with time. The effect of the AO enzymes is mutually dependent and is determined by the level of lipid peroxidation. By the end of one-month adaptation the glutathione concentration and activity of the defence enzymatic system functions on another steady level which differs from that at low-altitude.
Ozeredenko
V G
VG
Fedorova
L P
LP
Rysalieva
Z K
ZK
Ibraimkulov
S D
SD
Kurganskiĭ
O V
OV
D000531:Altitude; D000818:Animals; D000975:Antioxidants; D002374:Catalase / Q000502:physiology*; D005978:Glutathione / Q000502:physiology*; D005979:Glutathione Peroxidase / Q000502:physiology*; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000502:physiology*
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione
Antioksidantnaia zashchitnaia sistema v usloviiakh vysokogor'ia.