Association between fever and reduced renal concentrating capacity.
The renal concentrating capacity was assessed in 18 adult patients with febrile infections of non-renal origin. Urine osmolatity was determined after overnight fluid deprivation for 10 hours followed by subcutaneous administration of 4 micrograms of desmopressin. All patients had a transient reduction of the concentrating capacity as compared to a subsequent test performed one month later (p less than 0.001). During the febrile disease, 12 of 18 patients could not achieve a maximal urine osmolality above the lower limit (-2 SD) of an age-related reference interval. These results suggest that in febrile patients with bacteriuria, a reduced renal concentrating capacity does not necessarily mean that the infection is localised to the kidneys but may rather be explained by fever per se.
Sandberg
T
T
Department of Infectious Diseases, University of Göteborg, Ostra Hospital, Sweden.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000503:physiopathology; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007671:Kidney Concentrating Ability / Q000502:physiology*; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014777:Virus Diseases / Q000503:physiopathology