title: [Short-term treatment of thrombosis of heart valve prostheses with high doses of streptokinase. Presentation of 5 cases].
abstract: Five cases of thrombosis of cardiac prosthetic valves were treated with high dose fibrinolytic drugs during a short period of time. There were 3 mitral, one tricuspid and one pulmonary prosthetic valves. In 3 cases the treatment was successful without significant complications. Another patient, a woman in early pregnancy, died shortly after the treatment. The last patient required surgery as the cause of valve obstruction was a fibrous pannus virtually without thrombus formation. This diagnosis was intraoperative. The reported therapeutic modality permits a rapid resolution of valve obstruction. If this is not the case, surgery may be immediately carried out when the hemodynamic condition of the patient is still adequate.
authors.affiliation: Servicio de Hematología, Hospital de la Santa Creu i Sant Pau, Barcelona.
authors.forename: J C
authors.initials: JC
authors.lastname: Souto
authors.forename: I
authors.initials: I
authors.lastname: Zuazu-Jausoro
authors.forename: J
authors.initials: J
authors.lastname: Mateo
authors.forename: X
authors.initials: X
authors.lastname: Borrás
authors.forename: J
authors.initials: J
authors.lastname: Fontcuberta
mesh_terms: D000328:Adult; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D013300:Streptokinase
vernacular_title: Tratamiento corto de las trombosis de prótesis valvulares cardíacas con altas dosis de estreptocinasa. Presentación de cinco casos.