title: Cell cycle-specific expression and nuclear binding of DNA polymerase alpha.
abstract: The expression and distribution of DNA polymerase alpha was measured by cytometry and confocal laser scanning microscopy. Expression was proportional to DNA content in proliferating cells, while only S-phase cells retained DNA polymerase alpha after detergent extraction. Nuclear DNA polymerase alpha binding may be one of the key events of S-phase entry.
authors.affiliation: Department of Biophysics, Norwegian Radium Hospital, Oslo.
authors.forename: T
authors.initials: T
authors.lastname: Stokke
authors.forename: B
authors.initials: B
authors.lastname: Erikstein
authors.forename: H
authors.initials: H
authors.lastname: Holte
authors.forename: S
authors.initials: S
authors.lastname: Funderud
authors.forename: H B
authors.initials: HB
authors.lastname: Steen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000201:enzymology; D002453:Cell Cycle; D002460:Cell Line; D002467:Cell Nucleus / Q000502:physiology* / Q000648:ultrastructure; D002478:Cells, Cultured; D004257:DNA Polymerase II / Q000378:metabolism*; D005434:Flow Cytometry; D016193:G1 Phase; D006801:Humans; D007834:Lasers; D016196:S Phase
chemical_list: D004257:DNA Polymerase II