title: [Treatment of hypercholesterolemic patients of different age with simvastatin: 1-year study].
abstract: Nowadays there is no direct evidence that lowering cholesterol may reduce the CHD in the elderly; however, several evidences suggest the potential benefit of a dietetic and/or pharmacologic intervention in healthy young-old hypercholesterolemics. In this study we evaluated the efficacy and tolerability of simvastatin, alone or in combination with cholestyramine, in two groups of patients (group A: age 30-55 years and group B: age 60-75 years) with primary hypercholesterolemia, over a 48-week period. In both groups Simvastatin induced a significant reduction in total and LDL cholesterol (p less than 0.001 both), with a decrease of the total/HDL cholesterol ratio (p less than 0.001). A reduction of the apo-B100 levels was also observed (respectively p less than 0.01 and p less than 0.001) with a significant improvement of the apo-B100/apo-A1 ratio (p less than 0.01). Simvastatin was well tolerated and free of remarkable side effects in both groups.
authors.affiliation: Istituto di Medicina e Chirurgia geriatrica, Ospedale Molinette, Università, Torino.
authors.forename: L
authors.initials: L
authors.lastname: Pernigotti
authors.forename: M
authors.initials: M
authors.lastname: Bo
authors.forename: L
authors.initials: L
authors.lastname: Poli
authors.forename: M
authors.initials: M
authors.lastname: Zanocchi
authors.forename: U
authors.initials: U
authors.lastname: Fiandra
authors.forename: V
authors.initials: V
authors.lastname: Pedrazzini
authors.forename: F
authors.initials: F
authors.lastname: Fabris
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002792:Cholestyramine Resin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008148:Lovastatin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D019821:Simvastatin; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002792:Cholestyramine Resin; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin
vernacular_title: Trattamento di pazienti ipercolesterolemici di diversa età con simvastatina. Studio di un anno.