title: Controlled intraoral delivery of hydrocortisone sodium succinate.
abstract: Controlled release of hydrocortisone sodium succinate from a device consisting of a drug containing a core of polymethyl methacrylate was achieved by the use of a design incorporating impermeable barriers to drug diffusion and the use of a semipermeable membrane. Initial in vivo study showed sustained intraoral delivery of hydrocortisone sodium succinate during a 6-day period.
authors.affiliation: School of Clinical Dentistry, University of Sheffield, England.
authors.forename: I M
authors.initials: IM
authors.lastname: Brook
authors.forename: R
authors.initials: R
authors.lastname: van Noort
authors.forename: A V
authors.initials: AV
authors.lastname: Pandurangi
authors.forename: A
authors.initials: A
authors.lastname: Price
mesh_terms: D000284:Administration, Oral; D003692:Delayed-Action Preparations; D004058:Diffusion; D004867:Equipment Design; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D066298:In Vitro Techniques; D008297:Male; D008567:Membranes, Artificial; D008768:Methylmethacrylates; D012463:Saliva / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D008768:Methylmethacrylates; D013607:Tablets; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone