Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.
We compared the relative toxicities of standard concentrations of two magnetic resonance imaging (MRI) contrast agents, ionic gadolinium diethylenetriaminepentacetic acid (DTPA) and low-osmolar gadolinium-1, 4, 7 tris (carboxymethyl)-10-(2'-hydroxypropyl)-1, 4, 7, 10 tetra-azacyclododecane (HP-DO3A) with that of the conventional radiographic contrast medium meglumine diatrizoate, when extravasated into the deep dermal tissues of laboratory rats. Gadolinium-DTPA caused moderate necrosis, hemorrhage, and edema which was not statistically different than meglumine diatrizoate. In contrast, gadolinium HP-DO3A was significantly less toxic than meglumine diatrizoate. Additional experience will be needed in order to determine whether these laboratory results will be clinically relevant in humans.
Cohan
R H
RH
Department of Radiology, Duke University Medical Center, Durham, North Carolina.
Leder
R A
RA
Herzberg
A J
AJ
Hedlund
L W
LW
Wheeler
C T
CT
Beam
C A
CA
Nadel
S N
SN
Dunnick
N R
NR
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005682:Gadolinium / Q000633:toxicity*; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds / Q000633:toxicity*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D009994:Osmolar Concentration; D004369:Pentetic Acid / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D003974:Diatrizoate Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA