Serological responses of rams to a Brucella ovis-vitamin E adjuvant vaccine.
Rams which were vaccinated at 6-8 months of age with a water-in-oil Brucella ovis-vitamin E adjuvant vaccine had significantly higher serum antibody levels than rams vaccinated with a commercial B. ovis bacterin or B. melitensis Rev 1. The adjuvant vaccine did not cause abscesses at the site of injection as some water-in-oil emulsions do. Two years after vaccination, the vitamin E adjuvant-vaccinated rams had higher antibody level than the other groups. This was most likely due to a secondary response to naturally occurring infection with B. ovis.
Tengerdy
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RP
Department of Microbiology, Colorado State University, Fort Collins 80523.
Ameghino
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Riemann
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002002:Brucella / Q000276:immunology; D002004:Brucella Vaccine / Q000276:immunology*; D002006:Brucellosis / Q000517:prevention & control / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D004823:Epididymitis / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D012756:Sheep / Q000276:immunology*; D012757:Sheep Diseases / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D002004:Brucella Vaccine; D014810:Vitamin E