title: Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression.
abstract: The nucleotide and amino acid sequences for rat type I angiotensin II receptor were deduced through molecular cloning and sequence analysis of its complementary DNAs. The rat angiotensin II receptor consists of 359 amino acid residues and has a sequence similar to G protein-coupled receptors. The expression of this receptor gene was detected in the adrenal, liver and kidney by Northern blotting. Sodium deprivation positively modulated the expression of the receptor gene in the adrenal. No detectable change was observed in the expression levels of this receptor gene between spontaneously hypertensive rats and Wistar-Kyoto rats in the tissues examined including the adrenal, brain, kidney and liver. Interestingly the expression of this receptor gene was developmentally regulated.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
authors.forename: N
authors.initials: N
authors.lastname: Iwai
authors.forename: Y
authors.initials: Y
authors.lastname: Yamano
authors.forename: S
authors.initials: S
authors.lastname: Chaki
authors.forename: F
authors.initials: F
authors.lastname: Konishi
authors.forename: S
authors.initials: S
authors.lastname: Bardhan
authors.forename: C
authors.initials: C
authors.lastname: Tibbetts
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Inagami
mesh_terms: D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015723:Gene Library; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction / Q000379:methods; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
chemical_list: D015345:Oligonucleotide Probes; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D004247:DNA; D002118:Calcium