Serum immunoglobulin G subclasses in children infected with human immunodeficiency virus type 1.
We studied serum concentrations of IgG subclasses in 47 human immunodeficiency virus 1-infected (17 asymptomatic and 30 symptomatic) children. Thirty-nine of 47 (83%) had an abnormality of at least 1 subclass. Sixteen had only elevated IgG1, 6 had only elevated IgG3 and 12 had elevated IgG1 and IgG3 concentrations. IgG2, IgG4 and combined IgG2-IgG4 deficiency was found in 3, 4 and 4 patients, respectively. IgG2 concentrations did not differ between patients with (n = 23) or without (n = 24) bacterial infections. Additionally the number of bacterial infections was similar between the patients with normal or low IgG2 and/or low IgG4. These data indicate that IgG subclass abnormalities are found in most children with human immunodeficiency virus 1 infection, but quantitative deficiencies of specific subclasses do not appear to explain the high frequency of bacterial infections occurring in these patients.
Roilides
E
E
Infectious Disease Section, National Cancer Institute, Bethesda, MD 20892.
Black
C
C
Reimer
C
C
Rubin
M
M
Venzon
D
D
Pizzo
P A
PA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000293:Adolescent; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D015497:HIV-1; D006801:Humans; D017099:IgG Deficiency; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification; D007223:Infant; D008297:Male
D007074:Immunoglobulin G