Non-steroidal anti-inflammatory drugs in domestic animals: I. Their classification, mechanism of action and pharmacological effects.
A large number of non-steroidal anti-inflammatory drugs, of different chemical groups are available for veterinary use. These drugs act mainly by inhibiting the formation of endoperoxides (prostaglandins and thromboxanes) through the inhibition of cyclo-oxygenase in the eicosanoid pathway. A wide range of pharmacological effects, including analgesic, antipyretic and anti-inflammatory effects occur as a result of this inhibition. The classification, mechanism of action and pharmacological effects of these drugs are reviewed.
Swan
G E
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Department of Pharmacology and Toxicology, University of Pretoria, Republic of South Africa.
D000820:Animal Diseases / Q000188:drug therapy; D000818:Animals; D000829:Animals, Domestic; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal