Enhanced diabetogenic effects of combined treatment with hydrochlorothiazide and prednisone in adjuvant arthritic rats.
Adjuvant arthritic rats received either hydrochlorothiazide (HCT) alone, prednisone (PR) alone, both drugs, or vehicle. HCT combined with PR enhanced the extent of hyperglycemia, hyperlipidemia, hypercholesterolemia, and elevation of serum urea concentration and glutamic pyruvic transaminase activity observed when either drug was given alone. These results suggest that administration of thiazide diuretics to treat edema encountered during anti-inflammatory steroid therapy may increase the risk of diabetes mellitus, atherosclerosis and certain thrombotic disorders. HCT did not reduce the anti-inflammatory activity of PR.
Atef
M
M
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Hanafy
M S
MS
Arbid
M S
MS
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000473:pathology / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000503:physiopathology; D005528:Foot / Q000473:pathology; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000633:toxicity*; D008055:Lipids / Q000097:blood; D008297:Male; D011241:Prednisone / Q000633:toxicity*; D051381:Rats
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D008055:Lipids; D006852:Hydrochlorothiazide; D002784:Cholesterol; D000410:Alanine Transaminase; D011241:Prednisone