DNA single strand-breaks in lymphocytes after metronidazole therapy.
DNA single strand-breaks were examined in lymphocytes of patients treated with metronidazole (CAS 443-48-1) for trichomonas vaginalis infection before, on day one, and day seven of treatment. Recommended dosage of metronidazole induces DNA single strand-breaks. Single strand-breaks were repaired after therapy. No irreversible DNA damage remains. The DNA repair mechanisms are genetically determined. Therefore a mutagenic effect of metronidazole must be discussed in patients with DNA repair defects.
Reitz
M
M
Department of Physiological Chemistry, University of Mainz, Fed. Rep. of Germany.
Rumpf
M
M
Knitza
R
R
D000328:Adult; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000188:drug therapy
D008795:Metronidazole