Chlordiazepoxide nonspecifically enhances consumption of saccharin solution.
Following the establishment of a saccharin-amphetamine, saccharin-lithium or saccharin-saline association, rats were given a two-bottle test of preference for saccharin and water. Thirty min prior to the test, half of the rats were pretreated with chlordiazepoxide (9 mg/kg) and half of the rats were pretreated with saline. The results revealed that pretreatment with chlordiazepoxide (CDP) nonselectively enhanced saccharin consumption regardless of whether the flavored solution had been paired with amphetamine, lithium or saline. These results provide evidence that CDP enhances the palatability of flavored solutions.
Parker
L A
LA
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario.
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects
D002707:Chlordiazepoxide; D008094:Lithium; D000661:Amphetamine; D012439:Saccharin