Hormonal control of macrophage function and glutamine metabolism.
Murine macrophages have been reported to utilize glutamine at high rates. However, the role of glutamine in macrophage function is still unknown. In the present study, the maximum glutaminase activity of macrophages was investigated under several endocrine dysfunctions that are known to cause alterations in macrophage function. The results obtained suggest that glutamine might play an important role in the onset of phagocytosis in inflammatory macrophages. Moreover, the studies show that insulin, glucocorticoids, and thyroid hormones may be responsible for the regulation of glutamine metabolism and, consequently, of macrophage function.
Costa Rosa
L F
LF
Laboratory of Experimental Pathophysiology, Instituto Butantan, São Paulo, Brasil.
Cury
Y
Y
Curi
R
R
D000315:Adrenalectomy; D000818:Animals; D002464:Cell Migration Inhibition; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology; D005972:Glutaminase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
D005938:Glucocorticoids; D006728:Hormones; D007328:Insulin; D014284:Triiodothyronine; D005973:Glutamine; D005972:Glutaminase; D013974:Thyroxine; D004837:Epinephrine; D008797:Metyrapone