Time-dependent effects of cholinergic blockade of the striatum on memory.
Rats were trained on a passive avoidance task, and a retention test was carried out 24 h later. Scopolamine was injected into the anterior striatum at one of various intervals following training: at 2 min it produced amnesia; an intermediate degree of impairment was found when given 8 min after training. With a delay of 15 min, this drug did not produce an interference with memory. These observations suggest that striatal cholinergic activity is involved in memory consolidation.
Diaz del Guante
M A
MA
Laboratorio de Psicofisiologia, Universidad Veracruzana, México.
Cruz-Morales
S E
SE
Prado-Alcalá
R A
RA
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D010276:Parasympatholytics; D012601:Scopolamine