[The effect of prolonged gamma irradiation at a decreasing dose rate on survivability and gene mutation induction in cultured Chinese hamster cells].
Continuous gamma irradiation at decreasing dose rate was shown to be less effective than acute exposure with regard to the lethal effect and frequency of mutations of resistance to 6-thioguanine in cultured Chinese hamster cells. The cell population subjected to continuous irradiation was more radioresistant than the intact one. Lethal and genetic effects of continuous irradiation at decreasing dose rate were mainly determined by the contribution of the radiation dose received during the first 24 h of exposure.
Feoktistova
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Elisova
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Stavrakova
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NM
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D004351:Drug Resistance / Q000528:radiation effects; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D008940:Mitotic Index / Q000528:radiation effects; D009154:Mutation / Q000528:radiation effects*; D013866:Thioguanine / Q000037:antagonists & inhibitors; D013997:Time Factors
D013866:Thioguanine
Vliianie protiazhennogo gamma-oblucheniia so spadaiushcheĭ moshchnost'iu dozy na vyzhivaemost' i induktsiiu gennykh mutatsiĭ v kul'tiviruemykh kletkakh kitaĭskogo khomiachka.