Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding.
After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate.
Schön
H J
HJ
Department of Medical Chemistry, University of Vienna, Austria.
Kremser
K
K
Prager
C
C
Kramar
R
R
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002994:Clofibrate / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007521:Isocitrate Dehydrogenase; D002994:Clofibrate