The preparation and properties of bromoacetylphosphonic acid.
Bromoacetylphosphonic acid, Br-CH2-CO-PO3H2, was made by brominating dimethyl acetylphosphonate and de-esterifying with HBr. It proves to be a powerful alkylating agent, reacting rapidly with GSH, with a rate constant of about 6M(-1).s(-1) at pH6.
Sparkes
M J
MJ
Department of Biochemistry, University of Cambridge, U.K.
Dixon
H B
HB
D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000477:Alkylating Agents; D009943:Organophosphorus Compounds; C069017:bromoacetylphosphonate; D005978:Glutathione