title: Murine Taenia crassiceps cysticercosis: H-2 complex and sex influence on susceptibility.
abstract: Several inbred strains of mice were infected by intraperitoneal injection of ten Taenia crassiceps cysticerci per mouse. Genes linked with the major histocompatibility complex (H-2) were found to influence parasite growth greatly, as demonstrated by the different parasite loads of H-2 congenic mice with BALB background: BALB/c (H-2d) mice were the most susceptible, whereas BALB/k (H-2k) and BALB/b (H-2b) animals were comparatively resistant. Non-H-2 genes had no significant effect on susceptibility in H-2d strains, as reflected by the similar parasite loads in BALB/c, DBA/2, and (BALB/c x DBA/2)F1 mice. Using the H-2b (BALB/b, C57BL/6J) and H-2k (C3H/HeJ, BALB/k, and C3HeB/FeJ) strains, we found that non-H-2 background genes caused a small but significant influence on parasite load. A recombinant mouse strain alleles (Kk, Ik, Sd, Dd) was also susceptible, indicating that S and/or D regions of the H-2d complex are probably involved in the control of resistance to murine cysticercosis. Females of all mouse strains were more susceptible than males. The same effects were observed for H-2 genes and sex, with two strains of T. crassiceps differing in their rate of growth.
authors.affiliation: Instituto de Investigaciones Biomédicas, UNAM México, D.F.
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: M L
authors.initials: ML
authors.lastname: Diaz
authors.forename: F
authors.initials: F
authors.lastname: Valdez
authors.forename: R M
authors.initials: RM
authors.lastname: Montoya
authors.forename: T
authors.initials: T
authors.lastname: Govezensky
authors.forename: C
authors.initials: C
authors.lastname: Lomeli
authors.forename: C
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000235:genetics* / Q000276:immunology / Q000469:parasitology; D003552:Cysticercus / Q000254:growth & development*; D005260:Female; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010529:Peritoneal Cavity / Q000469:parasitology; D012727:Sex Characteristics; D013997:Time Factors