title: Successful treatment of adult Henoch-Schönlein purpura with factor XIII concentrate.
abstract: We report the cases of three adult patients with severe abdominal complications of Henoch-Schönlein purpura who had low activity of factor XIII during the acute phase of the disease. In all three cases, abdominal symptoms and purpura immediately responded to heat-treated, placenta-derived factor XIII concentrate. No adverse effects were experienced. Factor XIII concentrate replacement should be considered as the initial treatment for severe abdominal symptoms in adult Henoch-Schönlein purpura associated with a decreased level of factor XIII activity.
authors.affiliation: Department of Dermatology, Tenri Hospital, Nara, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Utani
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: A
authors.initials: A
authors.lastname: Shinya
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Takakuwa
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Suzaki
authors.forename: K
authors.initials: K
authors.lastname: Danno
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005176:Factor XIII / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000473:pathology / Q000628:therapy*; D008297:Male; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy
chemical_list: D005176:Factor XIII