Embryotoxicity and teratogenicity of DL111-IT, an early pregnancy-terminating agent, in the subsequent gestation following administration in rats.
DL 111-IT is a new non-hormonal early pregnancy-terminating agent. The subsequent embryotoxic and teratogenic effects of DL111-IT were studied in the rats whose first pregnancy had been terminated by the agent. The secondary pregnancy of the treated rats were allowed to initiate at 30-, 45-, and 90-day intervals, respectively, after the termination of the first pregnancy. The toxicities primed with DL111-IT, such as resorbed embryos and nephrohydrosis fetuses, were found to be 8.0% and 8.5%, respectively, in the rats with pregnancy at 30-day interval. This is significantly different from 4.0% resorbed embryos and 2.4% nephrohydrosis fetuses in vehicle control (P less than 0.05). However, the rate of resorbed embryos decreased to 7.0% or 6.0% in the rats with pregnancy at 45- or 90-day intervals, respectively. No other significant embryotoxicity and teratogenicity were observed in those rats initiating their pregnancy 45 days later after first-pregnancy termination by DL111-IT. Thus, DL111-IT appears to have very low subsequent toxicity in the course of rat pregnancy cycles.
Zhou
H J
HJ
Department of Pharmacology, School of Pharmacy, Zhejiang Medical University, Hangzhou, P.R. China.
Fang
R Y
RY
Yang
B Z
BZ
Zhang
Y P
YP
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D015994:Incidence; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000008:administration & dosage / Q000633:toxicity*
D000020:Abortifacient Agents, Nonsteroidal; D014230:Triazoles; C030266:3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole