title: Prevalence of neuropsychological deficit in HIV infection. Incipient signs of AIDS dementia complex in patients with AIDS.
abstract: The present study attempts to estimate the prevalence of Aids Dementia Complex assessed by neuropsychological testing in Norwegian patients with AIDS using a clinical control group with acute leukemia and an asymptomatic HIV-positive group as reference groups. Newly diagnosed patients with AIDS and not receiving zidovudine or other anti-viral drugs, patients with asymptomatic HIV infection, and newly diagnosed patients with acute leukemia, were studied with a battery of neuropsychological tests. Speeded tests and composite non-verbal measures discriminated significantly between groups. The results indicate higher than 50% prevalence of ADC in newly diagnosed Norwegian patients with AIDS. Our findings indicate that the AIDS population may contain two distinct groups, a subgroup with ADC and a subgroup with persistently normal neuropsychological function. The group with asymptomatic HIV infection showed normal neuropsychological performance.
authors.affiliation: Department of Behavioral and Psychosomatic Medicine, National Hospital, Oslo, Norway.
authors.forename: I
authors.initials: I
authors.lastname: Reinvang
authors.forename: S S
authors.initials: SS
authors.lastname: Frøland
authors.forename: V
authors.initials: V
authors.lastname: Skripeland
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000523:psychology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011594:Psychometrics; D014057:Tomography, X-Ray Computed; D014888:Wechsler Scales / Q000706:statistics & numerical data