title: [Clinical course of premature and newborn infants of mothers with HELLP syndrome].
abstract: The HELLP-syndrome is complicated by a maternal mortality of 3.5% and a perinatal mortality between 9.5 and 60%. It is a variant of severe preeclampsia which includes hemolysis, elevated liver enzymes and low platelets. It is described in the literature that neonates of mothers with HELLP-syndrome show characteristic symptoms especially thrombocytopenia, leukocytopenia and prenatal somatic dystrophy. In this retrospective investigation of 36 preterm and term infants of mothers with HELLP-syndrome we found the following results: 1. Thrombocytopenia was seen in 11% and leucocytopenia in 12% of the analysed cases. Anemia was seen in 10% of the analysed neonates. They needed transfusion of blood. The rate of prenatal somatic dystrophy was increased (58%). 2. Elevated blood pressure was observed in 29% of the neonates within the analysed interval. The time of artificial ventilation of preterm infants with maternal HELLP-syndrome was in 37% extended in comparison with infants without HELLP-syndrome in pregnancy. 3. The perinatal mortality was 8%. All observed infants during delivery and of the neonatal period in our collective survived.
authors.affiliation: Abt. Allgemeine Pädiatrie, Universitäts-Kinderklinik Kiel.
authors.forename: W
authors.initials: W
authors.lastname: Nikischin
authors.forename: A
authors.initials: A
authors.lastname: Conradt
authors.forename: H
authors.initials: H
authors.lastname: Schröder
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000743:Anemia, Hemolytic / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality; D001219:Aspartate Aminotransferases / Q000097:blood; D001724:Birth Weight / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000201:enzymology / Q000401:mortality; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007970:Leukopenia / Q000175:diagnosis / Q000201:enzymology / Q000401:mortality; D008111:Liver Function Tests; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality; D011247:Pregnancy; D013577:Syndrome; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000201:enzymology / Q000401:mortality
chemical_list: D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Klinische Verläufe bei Früh- und Neugeborenen von Müttern mit HELLP-Syndrom.