title: [Lung maturation during artificial placentation and mechanical lung distension].
abstract: An new method of lung maturation during artificial placentation was evaluated during a series of 15 animal experiments in premature lambs (gestational age 125-132 days). Perfusion circuit with interposition of a membrane lung was connected with the umbilical vessels. Extracorporeal CO2-removal (ECCO2-R) and apneic oxygenation were provided during lung distension. The ultramicroscopic pattern approved a maturation of the lung during the procedure showing development of lamellar bodies and surfactant secretion into the alveolar space. The biochemical analysis of the tracheal fluid showed a significant increase of both PC and PG concentrations (3.225 +/- 1.112 mg/100g to 24.228 +/- 3.36 mg/100 g respectively 0.249 +/- 0.11 mg/100 g of 0.622 +/- 0.09 mg/100 g. The biophysical function of the lung was also improved as was shown by a significant increase of the statistical compliance. We conclude that artificial placentation and lung distension might be a new mode of prophylaxis for respiratory distress syndrome in critically immature babies.
authors.affiliation: Universitäts-Frauenklinik Bonn.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Westphal
authors.forename: W
authors.initials: W
authors.lastname: Decleer
authors.forename: J W
authors.initials: JW
authors.lastname: Dudenhausen
authors.forename: R
authors.initials: R
authors.lastname: Herbst
authors.forename: C
authors.initials: C
authors.lastname: Schmitz
authors.forename: D
authors.initials: D
authors.lastname: Krebs
authors.forename: E
authors.initials: E
authors.lastname: Saling
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005325:Fetal Organ Maturity; D008168:Lung / Q000196:embryology* / Q000648:ultrastructure; D010712:Phosphatidic Acids / Q000032:analysis; D010929:Placentation; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000378:metabolism; D012756:Sheep; D014132:Trachea / Q000378:metabolism
chemical_list: D010712:Phosphatidic Acids; D011663:Pulmonary Surfactants
vernacular_title: Lungenreifung während künstlicher Plazentation und mechanischer Lungenblähung.