Participation of the parasympathetic nervous system in the development of activity-stress ulcers.
The present study investigates the effects of truncal vagotomy and drug treatment, comprising atropine methylbromide and chlorisondamine, on the development of activity-stress ulcers in rats. To induce gastric lesions, female rats were housed individually in activity-wheel cages and subjected to a food-restricted schedule of only 1 hr food availability per day. Bilateral truncal vagotomy significantly prevented gastric ulceration, while those rats with vagotomy showed more running activity than sham-operated rats. Daily treatment with either methylatropine (3 and 6 mg/kg, s.c.) or chlorisondamine (2 and 4 mg/kg, i.p.) also significantly decreased the severity of lesions without a significant reduction in running activity. This evidence suggests that the development of activity-stress ulcers is mainly due to the hyperactivity of the peripheral parasympathetic nervous system.
Doi
K
K
First Department of Surgery, Ehime University School of Medicine, Japan.
Iwahashi
K
K
Tsunekawa
K
K
D000818:Animals; D001286:Atropine Derivatives / Q000627:therapeutic use; D002714:Chlorisondamine / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D009043:Motor Activity / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D015167:Vagotomy, Truncal
D001286:Atropine Derivatives; D010276:Parasympatholytics; C006649:methylatropine; D002714:Chlorisondamine