title: [Development of atopic disease in early childhood--predisposing factors].
abstract: In this study, we attempted to find factors which predispose infants to atopy. 200 unselected newborns were followed up to 3 years of age. Children with elevated cordblood IgE or positive family history developed atopic disease significantly more frequent (p less than 0.05, p less than 0.01). Parental smoking or formula feeding alone did not influence the frequency of subsequent atopic disorders. However, in combination with reduced cordblood CD8-cells atopy was observed significantly more often (p less than 0.05, p less than 0.025). Similar results were found in children with reduced cordblood CD3-cells, whose parents were smokers (p less than 0.01). These results suggest that factors which alone do not influence atopy can enhance each other to predispose atopic disease in early childhood.
authors.affiliation: Kinderklinik und Poliklinik der Technischen Universität München.
authors.forename: S
authors.initials: S
authors.lastname: Liptay
authors.forename: C P
authors.initials: CP
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Grübl
authors.forename: R
authors.initials: R
authors.lastname: Franz
authors.forename: P
authors.initials: P
authors.lastname: Emmrich
mesh_terms: D001249:Asthma / Q000209:etiology / Q000235:genetics / Q000276:immunology; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000209:etiology / Q000235:genetics / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000209:etiology / Q000235:genetics / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D011446:Prospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000209:etiology / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014581:Urticaria / Q000209:etiology / Q000235:genetics / Q000276:immunology
chemical_list: D014028:Tobacco Smoke Pollution; D007073:Immunoglobulin E
vernacular_title: Atopieentwicklung in der frühen Kindheit--Prädisponierende Faktoren.