Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult.
Parathyroid hormone-related peptide (PTHrP, PLP) has previously been identified and assays are now available which can be used in clinical situations. A case is reported of a normocalcaemic young adult female in whom multifocal recurrent giant cell osteolytic lesions in the maxilla and elsewhere were associated with a raised plasma level of parathyroid hormone-related peptide. The lesions were histologically identical to reparative giant cell granuloma of the jaws and to osteitis fibrosa cystica associated with hyperparathyroidism.
Davis
J P
JP
Department of Head and Neck Surgery, Royal Marsden Hospital, London.
Archer
D J
DJ
Fisher
C
C
Wimalawansa
S J
SJ
Baldwin
D
D
D000328:Adult; D001847:Bone Diseases / Q000473:pathology; D002574:Cervical Vertebrae / Q000473:pathology; D005260:Female; D006101:Granuloma, Giant Cell / Q000097:blood* / Q000473:pathology; D006801:Humans; D008439:Maxillary Diseases / Q000097:blood* / Q000473:pathology; D009363:Neoplasm Proteins / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*; D012008:Recurrence; D012272:Ribs; D013122:Spinal Diseases / Q000473:pathology
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins