title: [The use of adaptogens for preventing suppurative-septic complications following prostatic adenomectomy].
abstract: Adaptive antiseptic potential of patients subjected to adenomectomy was quantified by measurement of protein synthesis according to the rate of 3H-thymidine inclusion into leukocytic DNA before and 4 hours after intravenous administration of 0.2 mg/kg prednisolone. In healthy controls this rate, when stimulated by prednisolone, rose 2.18 +/- 0.3-fold whereas in patients the rise did not exceed 1.07 +/- 0.07-fold. One-week administrations of adaptogens increased the latter rate 1.27-2.61-fold leading to less frequent infectious complications. A randomized trial of 118 patients involving the comparison of three different variants of adaptogens treatment against the control revealed the most favourable regimen: 0.15 U/kg im insulin, 0.1 mg/kg prednisolone, 0.2 mg/kg dibazol, 250 mg/kg methyluracil daily for 1 week preoperatively.
authors.forename: P S
authors.initials: PS
authors.lastname: Serniak
authors.forename: V K
authors.initials: VK
authors.lastname: Denisov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Vinentsov
authors.forename: P A
authors.initials: PA
authors.lastname: Chernobrivtsev
authors.forename: E M
authors.initials: EM
authors.lastname: Berko
authors.forename: G B
authors.initials: GB
authors.lastname: Guba
authors.forename: V V
authors.initials: VV
authors.lastname: Zakharov
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D000368:Aged; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods; D011468:Prostatectomy / Q000706:statistics & numerical data; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*
vernacular_title: Primenenie adaptogenov dlia profilaktiki gnoĭno-septicheskikh oslozhneniĭ posle adenoméktomii predstatel'noĭ zhelezy.