Hypogalactosylation of immunoglobulin G sugar chains and elevated serum interleukin 6 in Castleman's disease.
Immunoglobulin G (IgG) molecule has two N-linked complex type oligosaccharides, consisting of a mixture of at least 12 different structures. The pattern of these oligosaccharides is fairly constant in healthy individuals. In three patients with Castleman's disease, in whom serum interleukin 6 (IL-6) levels were elevated, agalactosyl species of serum IgG oligosaccharides were markedly increased as compared to those of normal healthy controls. A close relationship between increased IL-6 and altered IgG oligosaccharide structure is suggested.
Nakao
H
H
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Nishikawa
A
A
Nishiura
T
T
Kanayama
Y
Y
Tarui
S
S
Taniguchi
N
N
D000328:Adult; D002240:Carbohydrate Sequence; D005871:Castleman Disease / Q000097:blood* / Q000276:immunology; D002851:Chromatography, High Pressure Liquid; D004591:Electrophoresis, Polyacrylamide Gel; D005690:Galactose / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry* / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000097:blood / Q000737:chemistry*
D007074:Immunoglobulin G; D015850:Interleukin-6; D009844:Oligosaccharides; D005690:Galactose