[Active immunization to exogenous and endogenous antidepressants. The formation of antibodies to biogenic amines and peptide regulators].
The active immunization of rabbits and white rats to antidepressant sydnophen results in the formation of antibodies binding norepinephrine, dophamine, serotonine as well peptide regulatory compounds: substance P, pynorphine, vasopressin and beta-endorphin. The immunization against endogenic antidepressant thyroliberin induces the formation of antibodies to the same biogenic amines and to the gamma-aminobutyric acid, oxytocin and leu encephalin. The data obtained are discussed in connection with some physiological and biochemical changes found earlier during immunization to antidepressants.
Ashmarin
I P
IP
Obukhova
M F
MF
Mart'ianov
A A
AA
Danilova
R A
RA
Babskaia
N E
NE
Storozheva
Z I
ZI
Grechko
G K
GK
Kuznetsova
N V
NV
D000494:Allosteric Regulation / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood*; D000928:Antidepressive Agents / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000276:immunology; D001679:Biogenic Amines / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology; D010455:Peptides / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014611:Vaccination / Q000379:methods*
D000906:Antibodies; D000928:Antidepressive Agents; D001679:Biogenic Amines; D010455:Peptides
Aktivnaia immunizatsiia k ékzogennym i éndogennym antodepressantam. Obrazovanie antitel k biogennym aminam i peptidnym reguliatoram.