title: On the locus of medical discovery.
abstract: A search for consensus about the methodology of discovery among physicians and physiologists led the author to identify a crucial anomaly of medical historiography: in general, physicians stress the significance of clinicopathologic method, while physiologists emphasize the experimental. Hence, physicians and bench scientists might be perceived as members of epistemically distinct research traditions. However, analysis of the historical development of discoveries in medicine, exemplified by case studies in physiology, bacteriology, immunology, and therapeutics, reveals that the epistemic dichotomy is illusory. Both physicians and bench scientists discover in the same way: by identifying and explaining clinical anomalies. It is argued that the sociological role of experimentation is to dramatize clinical hypotheses and not test them in a Popperian sense.
authors.affiliation: Center for Health Science Policy, Arlington, VA 22201.
authors.forename: B P
authors.initials: BP
authors.lastname: Reines
mesh_terms: D000818:Animals; D049673:History, 20th Century; D006801:Humans; D010686:Philosophy, Medical / Q000266:history*; D012106:Research / Q000266:history*; D012107:Research Design