title: Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma.
abstract: Experiments were performed to characterize plasma lipid transfer protein activity (LTA), and the rate of [3H]CE transfer from HDL to lower density lipoproteins in plasma of hamsters. Compared to rabbits, hamster plasma has about one-tenth the level of d greater than 1.21 LTA but a relatively high level of VLDL-triacylglycerols, and a higher fractional rate of HDL-[3H]CE transfer in plasma (in vitro) than predicted by the d greater than 1.21 LTA. Like the rat, hamster plasma contains an inhibitor(s) of LTA; the level of the inhibitor activity in d greater than 1.21 g/ml plasma was similar in normal and hyperlipoproteinemic hamsters. Hypertriglyceridemia in sucrose-fed hamsters did not affect LTA, cholesteryl ester transfer or the plasma level of HDL-CE. However, a comparable degree of hypercholesterolemia was associated with a 122% increase in plasma d greater than 1.21 LTA and a 63% increase in the fractional rate of [3H]CE transfer from HDL to lower density lipoproteins in plasma. Cholesterol feeding in hamsters was associated with increased plasma levels of LDL-cholesterol and, to a lesser extent, with VLDL- and IDL-cholesterol.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY.
authors.forename: D W
authors.initials: DW
authors.lastname: Quig
authors.forename: C M
authors.initials: CM
authors.lastname: Arbeeny
authors.forename: D B
authors.initials: DB
authors.lastname: Zilversmit
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters / Q000097:blood*; D002791:Cholesterol, Dietary / Q000378:metabolism; D006224:Cricetinae; D006023:Glycoproteins; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008647:Mesocricetus; D011817:Rabbits
chemical_list: D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D006023:Glycoproteins; C059714:HDL cholesteryl ester; D008074:Lipoproteins; D008075:Lipoproteins, HDL; C030363:lipid transfer protein