title: Transient and long-lasting beneficial behavioral effects of grafts in the damaged hippocampus of rat.
abstract: One week after receiving bilateral neurotoxic lesions of their dorsal hippocampi, adult Wistar rats were bilaterally grafted with fetal hippocampal tissue suspensions. The behavior of the animals was tested during a period of 5 months after grafting to determine changes in lesion-induced deficits. The transplants caused various behavioral effects with different time courses. Grafted animals showed an early, however, transient amelioration of behavioral deficits in a T-maze alternation task and they performed with a long-lasting improvement in the alcove-test. Transplant histology demonstrated high levels of AChE-activity in patches correlating with clusters or rudimentary layers of pyramidal neurons.
authors.affiliation: C. and O. Vogt-Institute of Brain Research, University of Düsseldorf, F.R.G.
authors.forename: U
authors.initials: U
authors.lastname: Sprick
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D048588:Benzoxazines; D016380:Brain Tissue Transplantation; D005260:Female; D016332:Fetal Tissue Transplantation; D006624:Hippocampus / Q000196:embryology / Q000502:physiology / Q000637:transplantation*; D008297:Male; D010078:Oxazines; D011247:Pregnancy; D011712:Pyramidal Tracts / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver; D014184:Transplantation, Homologous
chemical_list: D048588:Benzoxazines; D010078:Oxazines; C028911:cresyl violet; D012834:Silver; D000110:Acetylcholinesterase