[Effect of resident macrophages on protein biosynthesis in the liver under conditions of reparative regeneration after partial hepatectomy].
In reparative regeneration of the liver after partial hepatectomy stimulation of the resident macrophages by lipopolysaccharides increases sharply the rate of 14C-leucine inclusion into total protein and into the soluble protein of the tissue supernatant. It is shown that synthesis not only of proteins necessary for restoration of the structural intactness of the liver increases but also of some blood serum proteins: total protein, protein of very low-density and low-density lipoproteins (VLDL and LDL) and of high-density lipoproteins (NDL2). The specific radioactivity of HDL3 protein reduces under such conditions. Increased protein biosynthesis in the liver under the effect of lipopolysaccharides precedes and contributes to intensification of the proliferative activity of the tissue of the damaged liver.
Panin
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LE
Sokolova
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MV
Usynin
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D000818:Animals; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
Vliianie rezidentnykh makrofagov na biosintez belka v pecheni v usloviiakh reparativnoĭ regeneratsii posle chastichnoĭ hepatéktomii.