title: [Animal experiment studies of development of anastomosis ulcers after reflux-inducing and reflux preventing stomach resection].
abstract: In an animal experiment the role of bile reflux in development of anastomotic ulcer after partial gastrectomy was investigated. On 45 pigs 2/3 partial gastrectomies and on 5 animals only laparotomies were carried out. The ulcer risk after reconstruction procedures with possible bile reflux was compared with reflux-free techniques. Anastomotic ulcer developed after maximal exposure of the gastric remnant to bile as well as after reflux-free reconstructions: B-II-Roux, 40 cm jejunum loop (n = 5/10); B-II-Roux, 20 cm jejunum loop (n = 3/5); B-II-Roux, 40 cm jejunum loop and truncal vagotomy (n = 1/5); B-I and choledochojejunostomy (n = 2/10); B-II-Roux, 40 cm jejunum loop and cholecystogastrotomy (n = 4/5). After B-I resection with medium duodeno-gastric reflux (n = 0/10) and in the control group (n = 0/5, laparotomy only) no ulcer occurred. Because basal acid output after B-I and B-II-Roux resection was reduced to O mval/h, stimulated gastric acid seems to be important in development of anastomotic ulcer. The experimental results prove the protective role of postresectional duodenogastric reflux. After partial gastrectomy for primary ulcer surgery reconstruction procedures guaranteeing duodenogastric reflux should be preferred to Roux-en-Y gastrojejunostomy.
authors.affiliation: Klinik für Allgemein-und Abdominalchirurgie, Johannes Gutenberg-Universität, Mainz, Bundesrepublik Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Walgenbach
authors.forename: T
authors.initials: T
authors.lastname: Junginger
authors.forename: C
authors.initials: C
authors.lastname: Hage
authors.forename: S
authors.initials: S
authors.lastname: Wölfinger
authors.forename: J
authors.initials: J
authors.lastname: Schollmeyer
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods; D000818:Animals; D001655:Bile Reflux / Q000473:pathology / Q000517:prevention & control*; D002768:Choledochostomy / Q000379:methods; D005743:Gastrectomy / Q000379:methods*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000473:pathology; D007582:Jejunostomy / Q000379:methods; D011178:Postgastrectomy Syndromes / Q000473:pathology / Q000517:prevention & control*; D012307:Risk Factors; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*; D013536:Suture Techniques; D013552:Swine
vernacular_title: Tierexperimentelle Untersuchungen zur Genese von Anastomosenulzera nach refluxbelasteter und refluxverhütender Magenresektion.