[Effect of pantethine on post-heparin lipolytic activity and lipid peroxidation in the myocardium].
In the present work the effect of the precursor of Co a D-bis (N- pantothenyl-beta-aminoethyl) disulfide--pantethine on post heparin lipolytic activity and the intensity of lipid peroxidation has been investigated. Pantethine in doses of 5 mg/kg enhanced post heparin lipolytic activity (60.6%) and lipoprotein lipase activity (39.9%) in plasma and reduced the amount of NEFA (35.1%) and content of MDA (57.4%) in the mitochondria.
Kumerova
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D000818:Animals; D000975:Antioxidants; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D006493:Heparin / Q000008:administration & dosage*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008055:Lipids / Q000037:antagonists & inhibitors; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D000960:Hypolipidemic Agents; D008055:Lipids; D010204:Pantetheine; C005425:pantethine; D006493:Heparin; D008071:Lipoprotein Lipase
Vliianie pantetina na postgeparinovuiu lipoliticheskuiu aktivnost' i perekisnoe okisleniie lipidov v miokarde.