[Experimental and clinical possibilities of MR spectroscopy of the heart].
MR-spectroscopy of the heart is a relatively new technique for the study of various aspects of cardiac metabolism. The majority of results has so far been obtained with the isolated perfused heart. Here, 31P-MR spectroscopy can be employed to measure high-energy phosphate metabolism and intracellular pH repeatedly and non-invasively. Using a technique called saturation transfer, velocities of enzymatic reactions, such as the creatine kinase reaction, can be measured. Intra- and extracellular Na+ and K+ concentrations can be registered with 23Na- and 39K-MR in conjunction with shift reagent. 13C-MR can be used to tackle carbohydrate metabolism. In-situ-R-spectroscopy allows determination of high-energy phosphates in intact large mammals. Clinical applications of MR-spectroscopy remain to be defined; preliminary results indicate high diagnostic and prognostic potential for patients with coronary artery disease and congestive heart failure.
Neubauer
S
S
Medizinische Universitätsklinik, Julius-Maximilians-Universität Würzburg.
Ertl
G
G
Krahe
T
T
Schindler
R
R
Hillenbrand
H
H
Lackner
K
K
Kochsiek
K
K
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D015428:Myocardial Reperfusion Injury / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D010101:Oxygen Consumption / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*
D004573:Electrolytes; D010710:Phosphates; D003402:Creatine Kinase
Experimentelle und klinische Möglichkeiten der MR-Spektroskopie des Herzens.