title: [The effect of oxidized cholesterol derivatives on the absorption and degradation of very low density beta-lipoproteins by human and rabbit hepatocytes].
abstract: In our study the influence of oxidated cholesterol derivatives (7 alpha, 7 beta-oxicholesterol, 7-ketocholesterol, cholestene-3-one) on binding and degradation of beta-VLDL by human and rabbit hepatocytes was investigated. Cholesterol oxy derivatives inhibit the degradation of beta-VLDL in rabbit hepatocyte culture. There is no such effect with human hepatocytes. However beta-VLDL binding with human hepatocytes is significantly decreased under oxidated cholesterol derivatives influence.
authors.forename: S A
authors.initials: SA
authors.lastname: Volgushev
authors.forename: V A
authors.initials: VA
authors.lastname: Kosykh
authors.forename: E A
authors.initials: EA
authors.lastname: Podrez
authors.forename: D K
authors.initials: DK
authors.lastname: Novikov
authors.forename: S M
authors.initials: SM
authors.lastname: Khlynin
authors.forename: R S
authors.initials: RS
authors.lastname: Karpov
mesh_terms: D000042:Absorption; D000328:Adult; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007457:Iodine Radioisotopes; D008079:Lipoproteins, VLDL / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D011817:Rabbits
chemical_list: D007457:Iodine Radioisotopes; D008079:Lipoproteins, VLDL; D002784:Cholesterol
vernacular_title: Vliianie okislennykh proizvodnykh kholesterina na pogloshchenie i degradatsiiu beta-lipoproteinov ochen' nizkoĭ plotnosti gepatotsitami cheloveka i krolika.