X-linked codominant genes control all types of non-major histocompatibility complex-restricted cytotoxicity.
In most individuals, natural killer (NK) activity is abolished after lymphocyte irradiation with 3,000 cGy, while lymphocytes from a minority of males retain 100% NK activity and lymphocytes from some females retain 50% NK activity after this dose. Radiation sensitivity of NK activity is controlled by X-linked codominant genes. The frequency of the allele that imparts resistance is 7%. We studied a unique family in which both parents have the resistant allele such that the father is completely resistant and the mother is partially resistant. The three offspring of this couple were one sensitive male, one partially resistant female, and one completely resistant female. The radiation sensitivity of nonspecific cytotoxic functions mediated by various types of effector cells from all five family members were evaluated in order to determine whether other cytotoxic functions were controlled by the same set of genes. The cytotoxic functions investigated were: NK and lymphokine-activated killing, anomalous killing and lectin-dependent cellular cytotoxicity, and antibody-dependent cell-mediated cytotoxicity. Our data indicate that the radiation sensitivity of all types of nonspecific cytotoxic cells is under the same genetic control.
Tilden
A B
AB
Department of Medicine, University of Alabama, Birmingham 35294.
Zarcone
D
D
Prasthofer
E F
EF
Lane
V G
VG
Acton
R T
RT
Grossi
C E
CE
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity / Q000235:genetics / Q000528:radiation effects; D003602:Cytotoxicity, Immunologic / Q000235:genetics* / Q000528:radiation effects; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology / Q000528:radiation effects; D007694:Killer Cells, Natural / Q000276:immunology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011836:Radiation Tolerance / Q000235:genetics; D014960:X Chromosome