title: Biological half-life of normal and truncated human IgG3 in scid mice.
abstract: The fractional catabolic rate of IgG in the body is regulated with precision in order to maintain appropriate serum concentrations. We have investigated the turnover rate of normal human IgG3, a newly identified, naturally occurring, truncated form of IgG3 and a human-mouse chimeric IgG3 antibody in an immunodeficient mouse strain, C.B-17 (SCID), lacking endogenous Ig. The half-life of non-truncated, normal serum IgG3 as well as the chimeric antibody was about 7 days, whereas truncated IgG3 had a shorter half-life of about 5 days. Due to the inherent immune defect, the SCID mouse could represent a versatile animal model for the determination of turnover rates, inasmuch as an immune response will not be mounted against foreign antigens.
authors.affiliation: Department of Immunology, Arrhenius Laboratories for Natural Sciences, Stockholm, Sweden.
authors.forename: M S
authors.initials: MS
authors.lastname: Hassan
authors.forename: M
authors.initials: M
authors.lastname: Abedi-Valugerdi
authors.forename: G
authors.initials: G
authors.lastname: Lefranc
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
authors.forename: C I
authors.initials: CI
authors.lastname: Smith
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D006207:Half-Life; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice
chemical_list: D007074:Immunoglobulin G