title: [Local estrogen premedication reduces the abortion time in prostaglandin E1 analogue-induced abortion in the 2nd trimester].
abstract: Twenty-eight patients (median gestational age 17 weeks) referred for induction of second trimester abortion, were randomized to intracervical preliminary treatment by either 50 mg 17 beta-oestradiol or placebo. Abortion was then induced by 1 mg prostaglandin E1 vagitories. The preliminary treatment caused a significant rise in cervical score and a significant reduction in induction-abortion time especially by reducing the number of patients with prolonged induction-abortion time.
authors.affiliation: Arhus Kommunehospital, gynaekologisk/obstetrisk afdeling.
authors.forename: L K
authors.initials: LK
authors.lastname: Petersen
authors.forename: N
authors.initials: N
authors.lastname: Uldbjerg
authors.forename: J G
authors.initials: JG
authors.lastname: Allen
mesh_terms: D000028:Abortion, Induced; D000282:Administration, Intravaginal; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011292:Premedication; D013997:Time Factors
chemical_list: C021182:gemeprost; D004958:Estradiol; D000527:Alprostadil
vernacular_title: Lokal østrogen-fobehandling reducerer aborttiden ven prostaglandin E1 analog-induceret abort i 2. trimester.