Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug.
The duration and magnitude of the hypotensive effect of a new, once daily dihydropyridine calcium channel blocking drug, OPC-13340, was assessed in 14 patients with essential hypertension during normal daily activities and programmed exercise testing. Intra-arterial ambulatory blood pressure (BP) monitoring was performed before and after one month's treatment. Mean reduction in day-time BP was 27/14 mmHg and night-time BP 18/11 mmHg (P less than 0.001 and 0.05 respectively). There was no change in heart rate throughout the 24 h. Satisfactory day-time control of systolic and diastolic BP using the drug as monotherapy was achieved in 58% and 88% of patients respectively, although adequate control of nocturnal systolic and diastolic BP occurred in only 54% and 50% of patients respectively. No postural hypotension occurred during tilt testing, and there was a significant reduction in the peak BP observed during both dynamic and isometric exercise. Side effects were mild and transient. Thus OPC-13340, given once daily, is an effective and well tolerated anti-hypertensive drug, with a prolonged 24-h action.
Broadhurst
P
P
Department of Cardiology, Northwick Park Hospital, Harrow, U.K.
Brigden
G
G
Hittel
N
N
Lahiri
A
A
Raftery
E B
EB
D000328:Adult; D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects; D004095:Dihydropyridines / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C048161:pranidipine