The transcriptional control proteins c-Myb and v-Myb contain a basic region DNA binding motif.
A class of transcriptional control proteins, typified by c-Myb, are characterised by a highly conserved N-terminal DNA binding domain, which is composed of either 2 or 3 imperfect repeats of about 52 amino acids. A sequence homology search of the SWISSPROT protein sequence data bank with this region from mouse c-Myb has allowed us to identify an area near the C-terminus of repeat 2 that contains a short sequence motif, known as the basic region, which forms the DNA binding site in both leucine zipper and helix-loop-helix transcription factors. We therefore propose that this region of repeat 2 and the homologous part of repeat 3 will form the Myb DNA binding site.
Carr
M D
MD
Laboratory of Molecular Structure, National Institute for Medical Research, Mill Hill, London, UK.
Mott
R F
RF
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry*; D051379:Mice; D008969:Molecular Sequence Data; D020626:Oncogene Proteins v-myb; D011518:Proto-Oncogene Proteins / Q000737:chemistry*; D020598:Proto-Oncogene Proteins c-myb; D015682:Retroviridae Proteins, Oncogenic / Q000737:chemistry; D014157:Transcription Factors / Q000737:chemistry*
D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors