Synthesis and schistosomicidal activity of 4-methyl-5-(aryl vinyl)-1,2-dithiole-3-thiones.
The synthesis of vinylogous of 1,2-dithiole-3-thione is described. The activity in experimental schistosomiasis (schistosomicidal activity) was tested with mice infected with Schistosoma mansoni. The reference compound was 4-methyl-5-(pyrazinyl)-1,2-dithiole-3-thione (oltipraz).
Abdaly
F
F
Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Université de Lille, France.
Vaccher
C
C
Berthelot
P
P
Debaert
M
M
Luyckx
M
M
Deblock
S
S
D000818:Animals; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012550:Schistosoma mansoni / Q000187:drug effects*; D012552:Schistosomiasis / Q000188:drug therapy / Q000469:parasitology; D012556:Schistosomicides / Q000138:chemical synthesis* / Q000627:therapeutic use
D012556:Schistosomicides