Cytogenetic study of a nodular hyperplasia of the thyroid after irradiation for Hodgkin's disease.
We describe cytogenetics of a case of nodular hyperplasia of the thyroid with papillary microcarcinoma following radiotherapy for Hodgkin's disease. The chromosomal pattern found was very heterogeneous with a clonal abnormality of chromosome 10, among others. Together with some recent data from the literature, this finding may point to an important role of chromosome 10 abnormalities in the pathogenesis of benign and malignant thyroid neoplasms.
van den Berg
E
E
Department of Pathology, University of Groningen, The Netherlands.
van Doormaal
J J
JJ
Oosterhuis
J W
JW
de Jong
B
B
Buist
J
J
Vos
A M
AM
Dam
A
A
Vermeij
A
A
D000328:Adult; D002291:Carcinoma, Papillary / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002879:Chromosomes, Human, Pair 10; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D006965:Hyperplasia; D007621:Karyotyping; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology