Species variation in the atherogenic profile of monkeys: relationship between dietary fats, lipoproteins, and platelet aggregation.
Because lipoproteins and platelet aggregation have been implicated in atherogenesis, relative differences in the response of these variables to dietary fat saturation were compared in three species of monkeys differing in their susceptibility to atherosclerosis (cebus, rhesus, and squirrel monkeys). Both long-term (8-12 years) and short-term (8 weeks) responses to diets containing 31% fat calories were examined in the same monkeys. As expected, long-term feeding of coconut oil by comparison to corn oil produced significantly higher plasma concentrations of total cholesterol, LDL cholesterol, apoB, and triglycerides, as well as higher ratios of LDL/HDL cholesterol and apo B/apo A-I. These responses were characteristic of all species with cebus being most responsive and rhesus the least. The short-term plasma cholesterol response to animal fats (butter, lard, beef tallow) was significantly less than that to coconut oil. When fish oil was substituted for two-thirds of either corn oil or coconut oil, exceptional decreases occurred in plasma cholesterol and triglycerides, as well as in HDL cholesterol and apo A-I concentrations despite the fact that the fish oil diets contained more saturated fat and less polyenes than the corn oil diet. Platelet aggregation tended to increase with saturated fat consumption and greatly decreased with fish oil intake in all monkeys, although cebus monkeys were ten-fold more resistant to platelet aggregation than the other two species. The molecular species of platelet phosphatidylcholine (PC) varied with both the dietary fat fed and species of monkey. An inverse correlation (r = -0.60; p less than 0.001) was found between changes in one such PC molecular species (18:0-20:4) induced by diet and the platelet aggregation threshold. These results demonstrate that the lipemic and platelet responses to dietary saturated fat depend upon both the type of fat (i.e., the specific combination of dietary fatty acids, including the chain length of saturated fatty acids and the degree of polyunsaturation) and the species of monkey (genetic component) in which the response is elicited.
Pronczuk
A
A
Foster Biomedical Research Laboratory, Brandeis University, Waltham, Massachusetts 02254.
Patton
G M
GM
Stephan
Z F
ZF
Hayes
K C
KC
D000818:Animals; D001053:Apolipoproteins / Q000032:analysis; D001161:Arteriosclerosis / Q000097:blood*; D002428:Cebus; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002849:Chromatography, Gas; D000074263:Coconut Oil; D003314:Corn Oil; D004041:Dietary Fats / Q000008:administration & dosage*; D004198:Disease Susceptibility; D005260:Female; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008137:Longitudinal Studies; D008253:Macaca mulatta; D008297:Male; D010938:Plant Oils; D010974:Platelet Aggregation; D012453:Saimiri; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D004041:Dietary Fats; D008055:Lipids; D008074:Lipoproteins; D010938:Plant Oils; D014280:Triglycerides; D003314:Corn Oil; D002784:Cholesterol; D000074263:Coconut Oil