title: The in vivo and in vitro transmission ratio distortion of one complete and two partial t haplotypes in mice.
abstract: The effects of different types of insemination (normal and delayed matings and in vitro fertilization) on the transmission ratio distortion (TRD) of three t haplotypes were determined. The tw73 haplotype which contains all of the loci known to affect TRD is transmitted at equivalent frequencies in normal matings and in in vitro fertilizations (0.84 and 0.85, respectively) but at a significantly lower frequency (0.62) in delayed matings. The distal partial th18 haplotype is transmitted at equivalent frequencies in all types of insemination (0.66 to 0.70) while the proximal partial tw18 haplotype is transmitted in Mendelian frequencies in normal matings and in in vitro inseminations but at a significantly lower frequency in delayed matings. The results are discussed with reference to the current genetic model for transmission ratio distortion.
authors.affiliation: Department of Biology, Temple University, Philadelphia, PA 19122.
authors.forename: W
authors.initials: W
authors.lastname: Garside
authors.forename: C
authors.initials: C
authors.lastname: Ruangvoravat
authors.forename: P
authors.initials: P
authors.lastname: Dolan
authors.forename: N
authors.initials: N
authors.lastname: Hillman
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D003433:Crosses, Genetic; D046508:Culture Techniques; D005260:Female; D005306:Fertilization / Q000235:genetics*; D005307:Fertilization in Vitro; D005787:Gene Frequency; D006239:Haplotypes / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL