title: 2',5'-oligoadenylate synthetase, neopterin and beta 2-microglobulin in asymptomatic HIV-infected individuals.
abstract: This study examined 2',5'-oligoadenylate (2,5A) synthetase activity in 26 individuals during the asymptomatic phase of HIV infection and its correlation with neopterin or beta 2-microglobulin. In HIV-antibody-positive (HIV-Ab+) asymptomatic people, both neopterin and beta 2-microglobulin levels in sera were significantly elevated; in contrast, 2,5A-synthetase activity in peripheral blood mononuclear cells was not significantly higher than in HIV-antibody-negative controls. The 2,5A-synthetase levels in symptomatic people (AIDS-related complex and AIDS) were significantly higher than in either asymptomatic or control individuals. However, within the group of HIV-infected asymptomatic individuals, all three markers were positively correlated. In this group, neopterin values were negatively correlated with the number of CD4+ lymphocytes while a positive correlation was found between 2,5A-synthetase and the number of CD8+ lymphocytes. Asymptomatic people with detectable serum HIV p24 antigen had significantly higher 2,5A-synthetase, neopterin, beta 2-microglobulin and number of CD8+ lymphocytes. This study suggests that elevated 2,5A-synthetase activity may reflect a different aspect of host response to HIV infection than do elevated neopterin or beta 2-microglobulin.
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison.
authors.forename: P L
authors.initials: PL
authors.lastname: Witt
authors.forename: G T
authors.initials: GT
authors.lastname: Spear
authors.forename: M J
authors.initials: MJ
authors.lastname: Lindstrom
authors.forename: H A
authors.initials: HA
authors.lastname: Kessler
authors.forename: E C
authors.initials: EC
authors.lastname: Borden
authors.forename: J
authors.initials: J
authors.lastname: Phair
authors.forename: A L
authors.initials: AL
authors.lastname: Landay
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood*; D000386:AIDS-Related Complex / Q000201:enzymology; D000163:Acquired Immunodeficiency Syndrome / Q000201:enzymology; D015415:Biomarkers; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D015483:HIV Antibodies / Q000032:analysis; D015658:HIV Infections / Q000097:blood* / Q000201:enzymology; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000201:enzymology; D019798:Neopterin; D016176:T-Lymphocyte Subsets; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015483:HIV Antibodies; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin; D015088:2',5'-Oligoadenylate Synthetase