[The effect of oxidized cholesterol derivatives on the absorption and degradation of very low density beta-lipoproteins by human and rabbit hepatocytes].
In our study the influence of oxidated cholesterol derivatives (7 alpha, 7 beta-oxicholesterol, 7-ketocholesterol, cholestene-3-one) on binding and degradation of beta-VLDL by human and rabbit hepatocytes was investigated. Cholesterol oxy derivatives inhibit the degradation of beta-VLDL in rabbit hepatocyte culture. There is no such effect with human hepatocytes. However beta-VLDL binding with human hepatocytes is significantly decreased under oxidated cholesterol derivatives influence.
Volgushev
S A
SA
Kosykh
V A
VA
Podrez
E A
EA
Novikov
D K
DK
Khlynin
S M
SM
Karpov
R S
RS
D000042:Absorption; D000328:Adult; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007457:Iodine Radioisotopes; D008079:Lipoproteins, VLDL / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D011817:Rabbits
D007457:Iodine Radioisotopes; D008079:Lipoproteins, VLDL; D002784:Cholesterol
Vliianie okislennykh proizvodnykh kholesterina na pogloshchenie i degradatsiiu beta-lipoproteinov ochen' nizkoĭ plotnosti gepatotsitami cheloveka i krolika.