[Analysis of immunological response of regional lymph node lymphocytes from patients with gastric cancer after endoscopic local injection of biological response modifier (BRM)].
Local injection of BRM (OK-432 or Lentinan) around the cancer lesions via endoscope was performed on 66 gastric cancer patients preoperatively, and the regional lymph node lymphocytes in the surgical specimens were examined on T-cell subset, production of IL-2, and responsiveness to IL-2. The results were as follows: 1) In the metastatic lymph nodes, proportions of T-lymphocyte subsets, production of IL-2 and responsiveness to IL-2 did not change after local administration of OK-432 or Lentinan. 2) In the non-metastatic lymph nodes, percentage of CD4+4B4+ cells were significantly increased and production of IL-2 was markedly augmented after local injection of OK-432. On the other hand, percentage of CD8+CD11- cells were significantly increased and production of IL-2 was markedly enhanced after the local injection of Lentinan. These data suggested that the antitumor response of the non-metastatic lymph node lymphocytes was augmented after the local injection of OK-432 or Lentinan.
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Second Department of Surgery, Yokohama City University School of Medicine, Japan.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000096:biosynthesis; D007912:Lentinan / Q000008:administration & dosage / Q000627:therapeutic use; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000276:immunology* / Q000628:therapy; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000276:immunology*
D007155:Immunologic Factors; D007376:Interleukin-2; D007912:Lentinan; D010844:Picibanil