Activity of aniline in the mouse bone marrow micronucleus assay.
Aniline gave a positive response in the mouse bone marrow micronucleus assay 24 h after the second of two intraperitoneal injections of 80% of the median lethal dose (MLD). Negative results were observed at lower dose levels and at earlier and later sampling times. The significance of this unique activity profile is discussed within the context of the non-carcinogenicity of aniline to the mouse.
Ashby
J
J
ICI Central Toxicological Laboratory, Alderley Park, Macclesfield, Great Britain.
Vlachos
D A
DA
Tinwell
H
H
D000814:Aniline Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002875:Chromosomes / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009152:Mutagenicity Tests
D000814:Aniline Compounds; D003520:Cyclophosphamide; C023650:aniline