title: Disopyramide as a negative inotrope in obstructive cardiomyopathy in children.
abstract: Two children with left ventricular outflow tract obstruction due to myocardial hypertrophy received oral disopyramide as a negative inotrope. Both showed rapid improvement in clinical signs and by echo Doppler examination. Nearly complete abolition of severe left ventricular outflow tract obstruction was documented in each case. This experience may prompt further application of disopyramide as a therapeutic agent to relieve dynamic muscular subaortic obstruction in children.
authors.affiliation: University of Saskatchewan, Saskatoon.
authors.forename: W J
authors.initials: WJ
authors.lastname: Duncan
authors.forename: M J
authors.initials: MJ
authors.lastname: Tyrrell
authors.forename: B B
authors.initials: BB
authors.lastname: Bharadwaj
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002331:Carnitine / Q000097:blood; D002648:Child; D004206:Disopyramide / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging; D015150:Echocardiography, Doppler; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D013610:Tachycardia / Q000628:therapy; D014694:Ventricular Outflow Obstruction / Q000188:drug therapy*
chemical_list: D011433:Propranolol; D004206:Disopyramide; D002331:Carnitine