title: Forensic analysis of triazolam in human tissues using capillary gas chromatography.
abstract: A reliable and sensitive method has been developed to assess the concentrations of the hypnotic drug triazolam in human tissues, including putrefied tissues. The method involves a 3-step solvent extraction, clean-up on a silica gel column and gas chromatography using a nitrogen phosphorus detector and a capillary column. Estazolam was used as an internal standard. The calibration curve was linear over the concentration range 1 ng/g-1 microgram/g and the lower limit of detection was 0.5 ng/g. A forensic study was performed on the toxicological effects of triazolam using putrefied tissues.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kudo
authors.forename: T
authors.initials: T
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: S
authors.initials: S
authors.lastname: Kage
authors.forename: Y
authors.initials: Y
authors.lastname: Hida
mesh_terms: D000328:Adult; D002849:Chromatography, Gas / Q000379:methods*; D062787:Drug Overdose / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008099:Liver / Q000737:chemistry; D008297:Male; D011180:Postmortem Changes; D013405:Suicide / Q000331:legislation & jurisprudence; D014018:Tissue Distribution / Q000502:physiology; D014229:Triazolam / Q000032:analysis* / Q000493:pharmacokinetics / Q000506:poisoning
chemical_list: D014229:Triazolam