Autofluorescence of normal and malignant bronchial tissue.
In vivo autofluorescence spectra were obtained in 5 patients with carcinoma in situ, 26 patients with invasive tumors, and 1 patient with severe dysplasia. Significant spectral differences were observed between pre-cancerous, cancerous, and normal bronchial tissues. This difference may afford a method to image and/or detect early lung cancer by using tissue autofluorescence alone.
Hung
J
J
Cancer Imaging Section, British Columbia Cancer Agency, Vancouver, Canada.
Lam
S
S
LeRiche
J C
JC
Palcic
B
B
D001980:Bronchi / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000473:pathology; D005453:Fluorescence; D005470:Fluorometry; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013050:Spectrometry, Fluorescence