title: Ultrastructural studies of the effects of the ionophore lasalocid on Eimeria tenella in chickens.
abstract: The ultrastructural development of Eimeria tenella was studied in experimentally infected chicks fed 90 ppm lasalocid, an ionophorous anticoccidial antibiotic. Drug treatment was timed to target-specific endogenous stages. At 6 h after infection, many sporozoites within the epithelium showed degradation as a result of drug action. Only a few intact sporozoites were seen. The drug caused outer-membrane blistering, large surface swellings and enlarged mitochondria in both first- and second-generation merozoites. No effect on the gamonts was discerned.
authors.affiliation: Division of Microbiology and Genetics, School of Science, Polytechnic of East London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Daszak
authors.forename: S J
authors.initials: SJ
authors.lastname: Ball
authors.forename: R M
authors.initials: RM
authors.lastname: Pittilo
authors.forename: C C
authors.initials: CC
authors.lastname: Norton
mesh_terms: D000818:Animals; D002432:Cecum / Q000469:parasitology; D002645:Chickens / Q000469:parasitology; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology*; D004539:Eimeria / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D004848:Epithelium / Q000469:parasitology; D007832:Lasalocid / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D007832:Lasalocid