Pregnancy after oocyte donation to a woman with ovarian failure and classical galactosemia.
In summary, oocyte and pre-embryo donation may be used to establish pregnancy in women with galactosemia and ovarian failure. Reported is the first pregnancy after pre-embryo donation to a woman with classical galactose-1-phosphate uridyl transferase deficiency. Despite disturbances in galactose metabolism, the endometrial lining responded normally to exogenous hormone replacement and was receptive to pre-embryo implantation. Pregnancy support was provided by exogenously administered oral E2 and IM P for the initial 100 days, at which time placental hormone production solely maintained the gestation.
Sauer
M V
MV
Department of Obstetrics and Gynecology, University of Southern California, Los Angeles.
Kaufman
F R
FR
Paulson
R J
RJ
Lobo
R A
RA
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005693:Galactosemias / Q000150:complications*; D006801:Humans; D009865:Oocytes; D010049:Ovarian Diseases / Q000209:etiology / Q000503:physiopathology*; D010062:Ovulation Induction; D011247:Pregnancy
D006063:Chorionic Gonadotropin