Cerebrovascular responsiveness to hypercapnia in intracerebral tissue transplants.
Cerebral blood flow was measured using [14C]iodoantipyrine quantitative autoradiography in rats which had previously undergone unilateral ibotenate-induced nucleus basalis lesion followed by intracortical implantation of foetal basal forebrain cell suspensions. Transplants had no effect upon host cortical blood flow, although within the transplant itself, blood flow was significantly lower than the contralateral site. Both the transplant and host cortex exhibited a similar degree of hyperaemia in response to hypercapnia.
Sharkey
J
J
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, U.K.
McBean
D E
DE
Kelly
P A
PA
D000818:Animals; D001921:Brain / Q000196:embryology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D016332:Fetal Tissue Transplantation; D006935:Hypercapnia / Q000503:physiopathology*; D008297:Male; D009417:Nerve Tissue / Q000196:embryology / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains