Superoxide dismutases of pathogenic and non-pathogenic Streptococcus suis type 2 isolates.
Pathogenic and non-pathogenic isolates of Streptococcus suis type 2 were screened to determine whether differences in superoxide dismutase (SOD) synthesis could explain the observed differences in their pathogenicity and intracellular fate in macrophages. A single band of SOD activity of similar Rf value was visualised in PAGE gels in all isolates and inhibition studies suggested that the cofactor present was manganese. There was no correlation between specific SOD activity and virulence. It is unlikely, therefore, that SOD produced by S. suis type 2 mediates intracellular survival of pathogenic isolates in macrophages.
Langford
P
P
University Department of Paediatrics, John Radcliffe Hospital, Oxford, U.K.
Williams
A E
AE
Kroll
J S
JS
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D010641:Phenotype; D013045:Species Specificity; D013291:Streptococcus / Q000201:enzymology* / Q000302:isolation & purification / Q000472:pathogenicity; D013482:Superoxide Dismutase / Q000302:isolation & purification / Q000378:metabolism*; D013552:Swine; D014774:Virulence
D013482:Superoxide Dismutase