title: Plant anticancer agents, XLVIII. New cytotoxic flavonoids from Muntingia calabura roots.
abstract: From a cytotoxic Et2O-soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1-7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1-12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on 1H-1H COSY, 1H-13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines.
authors.affiliation: College of Pharmacy, University of Illinois, Chicago 60612.
authors.forename: N
authors.initials: N
authors.lastname: Kaneda
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: T
authors.initials: T
authors.lastname: Santisuk
authors.forename: P
authors.initials: P
authors.lastname: Tuchinda
authors.forename: J
authors.initials: J
authors.lastname: Udchachon
authors.forename: V
authors.initials: V
authors.lastname: Reutrakul
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids