title: Influence of material properties on the mechanical behaviour of the L5-S1 intervertebral disc in compression: a nonlinear finite element study.
abstract: A simple finite element model of the L5-S1 intervertebral disc body has been constructed; it is circular and symmetrical about the sagittal plane. The annulus fibrosus of the model was idealized as an inhomogeneous composite of an isotropic ground substance, reinforced by helically oriented collagen fibres so that the model has six different structural components namely: cortical bone, cancellous bone, cartilaginous endplates, nucleus pulposus, ground substance and collagen fibres. A sensitivity analysis of the material properties of each structural component was carried out by varying those properties for one structural component at a time and evaluating the changes in the biomechanical response to compressive displacements. Experimentally available relations between the applied compressive force and the vertical displacements, the nucleus pulposus pressure increase and the disc lateral bulge were used to evaluate the biomechanical responses for each set of material properties. Results showed that both the Poisson's ratio and the Young's modulus of the ground substance play an important role in the prediction of the biomechanical response.
authors.affiliation: Department of Mechanical Engineering, Queen's University, Kingston, Ontario, Canada.
authors.forename: A A
authors.initials: AA
authors.lastname: Rao
authors.forename: G A
authors.initials: GA
authors.lastname: Dumas
mesh_terms: D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000502:physiology; D002356:Cartilage / Q000502:physiology; D003094:Collagen / Q000502:physiology; D004548:Elasticity; D006801:Humans; D007403:Intervertebral Disc / Q000502:physiology*; D008159:Lumbar Vertebrae / Q000502:physiology*; D008954:Models, Biological; D016012:Poisson Distribution; D012447:Sacrum / Q000502:physiology*; D012680:Sensitivity and Specificity; D013718:Tensile Strength / Q000502:physiology
chemical_list: D003094:Collagen