[Effect of dalargin on energy metabolism of heart contractile function in acute blood loss].
The authors studied the mechanisms of disorders of energy provision of myocardial contractility in rabbits in hemorrhagic shock and appraised the efficacy of a new Soviet-produced agent dalargin possessing an antiadrenergic property. It is shown that dalargin exerts a significant effect on the condition of the cardiovascular system and the function of the myocardial mitochondria (MC). The effect differed depending on the time of the injection and the condition of the organism. Increase of the heart contractive function, improvement of MC function, and prolonged survival of the animals were encountered only in rabbits who received dalargin 30 minutes after blood loss. The mechanisms of the effects of dalargin in acute blood loss are discussed.
Shamkulashvili
G G
GG
Dumbadze
G G
GG
Mchedlishvili
T V
TV
Sharvashidze
V G
VG
Mineev
I F
IF
D000208:Acute Disease; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006470:Hemorrhage / Q000188:drug therapy*; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D013565:Sympatholytics / Q000494:pharmacology*
D013565:Sympatholytics; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na énergoobespechenie sokratitel'noĭ funktsii serdtsa pri ostroĭ krovopotere.