title: Occurrence, clinical manifestations, and prognosis of Guillain-Barré syndrome.
abstract: In order to obtain more information on the incidence of Guillain-Barré syndrome and recent developments in its prognosis, we analysed the severity and prognosis of Guillain-Barré syndrome in children diagnosed and treated during the years 1980-6 throughout Finland. The criteria for Guillain-Barré syndrome were fulfilled in 14 boys and 13 girls. The mean annual number of cases of Guillain-Barré syndrome was thus 3.9, giving a mean annual incidence of 0.38/100,000 of population under 15 years of age (95% confidence intervals 0.25 to 0.56/100,000). The incidence of Guillain-Barré syndrome causing permanent neurological defects in children under 15 years of age was 1.4/10 million annually (95% confidence intervals 0.035 to 7.8/10 million). Our figures appeared to be one fourth to a half of that reported earlier in children and even lower than those in adults. Although there were no deaths among our patients, mortality from Guillain-Barré syndrome seems to have remained similar for the last 20 years despite current awareness of the possibility of cardiac arrest and respiratory failure.
authors.affiliation: Department of Paediatrics, University of Oulu, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Rantala
authors.forename: M
authors.initials: M
authors.lastname: Uhari
authors.forename: M
authors.initials: M
authors.lastname: Niemelä
mesh_terms: D000293:Adolescent; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland; D006801:Humans; D007223:Infant; D008297:Male; D011129:Polyradiculoneuropathy / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology
chemical_list: D002556:Cerebrospinal Fluid Proteins