title: The pathogenesis of skin damage in venous disease: a review.
abstract: Venous ulceration remains a major cause of morbidity. Treatment has not improved significantly in recent years, possibly because our understanding of the pathophysiological mechanisms at work is still incomplete. We review the principal abnormalities found in the macro- and microcirculation in this condition and discuss the various theories put forward to explain the mechanism by which skin damage occurs.
authors.affiliation: Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London, U.K.
authors.forename: T R
authors.initials: TR
authors.lastname: Cheatle
authors.forename: S
authors.initials: S
authors.lastname: Sarin
authors.forename: P D
authors.initials: PD
authors.lastname: Coleridge Smith
authors.forename: J H
authors.initials: JH
authors.lastname: Scurr
mesh_terms: D005337:Fibrin / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008833:Microcirculation / Q000503:physiopathology; D012594:Scleroderma, Localized / Q000209:etiology; D012867:Skin / Q000098:blood supply*; D012883:Skin Ulcer / Q000209:etiology*; D013927:Thrombosis / Q000150:complications; D014689:Venous Insufficiency / Q000150:complications*; D014690:Venous Pressure / Q000502:physiology
chemical_list: D005337:Fibrin