Isogravacridonchlorine: a potent and direct acting frameshift mutagen from the roots of Ruta graveolens.
The furanoacridone alkaloid isogravacridonchlorine has been isolated from the roots of Ruta graveolens, the structure was elucidated by spectroscopic means. Its mutagenic activity and mode of action was characterized without as well as with metabolic activation using different Salmonella typhimurium strains.
Paulini
H
H
Institut für Botanik und Pharmazeutische Biologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Popp
R
R
Schimmer
O
O
Ratka
O
O
Röder
E
E
D000166:Acridines / Q000302:isolation & purification / Q000494:pharmacology; D000470:Alkaloids; D000818:Animals; D016368:Frameshift Mutation; D008099:Liver / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D010944:Plants / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D000166:Acridines; D000470:Alkaloids; D009153:Mutagens; C069662:isogravacridonchlorine