title: Secretion of triglyceride and ketogenesis by livers from spontaneous diabetic BB Wistar rats.
abstract: Livers from male and female BB Wistar spontaneously diabetic rats were perfused in vitro to determine the effects of spontaneously occurring insulin-dependent diabetes on the metabolism of fatty acid. The secretion of triglyceride and the incorporation of [1-14C] oleic acid into perfusate and hepatic triglyceride was reduced by the diabetic state, whereas beta-hydroxybutyrate production and output of total ketone bodies were increased. The spontaneous diabetic Wistar rat clearly is a suitable model to study the derangements induced in lipid/plasma lipoprotein metabolism by the insulin-dependent diabetic state; the data obtained with this model confirm our earlier observations on experimental insulin deficiency induced with alloxan, streptozotocin, and anti-insulin serum.
authors.affiliation: Department of Pharmacology College of Medicine, University of Tennessee, Memphis.
authors.forename: I
authors.initials: I
authors.lastname: Weinstein
authors.forename: T B
authors.initials: TB
authors.lastname: Patel
authors.forename: M
authors.initials: M
authors.lastname: Heimberg
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D005260:Female; D006885:Hydroxybutyrates / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D051381:Rats; D011913:Rats, Inbred BB; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D006885:Hydroxybutyrates; D007657:Ketone Bodies; D009829:Oleic Acids; D014280:Triglycerides; D019301:Oleic Acid; D020155:3-Hydroxybutyric Acid