title: [Bone marrow transplantation in the treatment of severe aplastic anemia].
abstract: Bone marrow transplantation (BMT) in patient affected by severe aplastic anemia (SAA), is successful in 70-80% of cases, when performed with HLA identical brother or syngeneic twin as donors, and in 11-45% of cases when performed from aploidentical-identical related or HLA identical unrelated donor. The different conditioning regimens (Cy alone or in combination with TBI) have shown similar results in the long term outcomes. Cyclosporin-A is very effective in avoiding rejection and controlling GVHD.
authors.affiliation: Clinica Pediatrica, Università di Pavia, IRCCS Policlinico S. Matteo, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: M
authors.initials: M
authors.lastname: Zecca
authors.forename: L
authors.initials: L
authors.lastname: Nespoli
authors.forename: F
authors.initials: F
authors.lastname: Severi
mesh_terms: D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male
vernacular_title: Il trapianto di midollo osseo nel trattamento dell'anemia aplastica grave.