title: Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes.
abstract: Serotonin inhibited in a concentration dependent way (10(-3) M to 10(-10) M) the LPS induced Tumor Necrosis Factor-alpha synthesis both, when added to the monocyte cultures from the beginning and when added together with the activating stimulus 8 hours before the end of the culture. The inhibitory effect was specifically blocked by the 5-HT1 and 5-HT2 serotonin antagonist methysergide and the 5-HT2 receptor antagonist ketanserin. This indicates that only the 5-HT2 receptor family (5-HT2 or 5-HT1C) may be involved in the inhibitory effect. Serotonin seems to play an important immunomodulatory role in macrophage functions.
authors.affiliation: Departamento de Sustancias Vasoactivas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Arzt
authors.forename: M
authors.initials: M
authors.lastname: Costas
authors.forename: S
authors.initials: S
authors.lastname: Finkielman
authors.forename: V E
authors.initials: VE
authors.lastname: Nahmod
mesh_terms: D006801:Humans; D007650:Ketanserin / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D011985:Receptors, Serotonin; D014409:Tumor Necrosis Factor-alpha; D012701:Serotonin; D007650:Ketanserin; D008784:Methysergide