The haemodynamic effect of Bitis nasicornis (rhinoceros horned viper) venom.
1. Intravenous venom (0.0625 mg/kg) in the dog caused an immediate increase in coronary blood flow due to a fall in coronary vascular resistance (CVR). 2. Subsequently, total peripheral resistance (TPR) fell causing a significant reduction in aortic blood pressure (ABP). 3. CVR and TPR returned to normal after 20 min but ABP did not recover completely. 4. The failure of ABP to recover was due to decreased stroke volume and cardiac output (CO). 5. Animals died after four doubling doses of venom following irreversible reductions in CO, ABP and coronary flow.
Alloatti
G
G
Dipartimento di Biologia Animale, Università di Torino, Italy.
Gattullo
D
D
Dalla Valle
R
R
Marsh
N A
NA
Pagliaro
P
P
Vono
P
P
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D014757:Viper Venoms / Q000494:pharmacology*
D014757:Viper Venoms