Characterization of a strongly immunogenic mouse leukemia line (DL811) undergoing spontaneous cure with tumor dormancy.
The strongly immunogenic B-cell leukemia line, DL811, was established from a spontaneous leukemia in DDD mice. When 10(6) DL811 cells were s.c. inoculated, all athymic DDD-nu/nu mice died of disseminated leukemia but less than 20% of euthymic DDD mice were spontaneously cured of it. Although cured mice resisted a challenge with 10(7) DL811 cells, they frequently died of relapse. Whole-body gamma-ray irradiation accelerated the relapse of leukemias, implying that leukemic cells can survive against host immune cell killing in a dormant state. L3T4+ Lyt-2+ T cells were suggested to have a significant role in spontaneous cure and maintenance of the dormant state.
Matsuzawa
A
A
Laboratory Animal Research Center, University of Tokyo, Japan.
Kaneko
T
T
Takeda
Y
Y
Ozawa
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002460:Cell Line; D005434:Flow Cytometry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000401:mortality; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009365:Neoplasm Regression, Spontaneous; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014916:Whole-Body Irradiation
D000911:Antibodies, Monoclonal