[The role of thromboxane A2 and prostacyclin in the pathogenesis of diabetes mellitus in children and adolescents].
The follow-up of children and adolescents (n-41) suffering from insulin-dependent diabetes mellitus has demonstrated that the increase of the thromboxane/prostacyclin ratio pointing to the derangement of microcirculatory regulation occurs during the decompensation phase of the disease and is a risk factor of the development of diabetic complications. The revealed disorders of arachidonic acid metabolism may be one of the causes of the tendency towards decrease of pulse arterial pressure in grave diabetes mellitus.
Vakhrusheva
L L
LL
Kniazev
Iu A
IuA
Martynova
M I
MI
Pirogova
L B
LB
D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D001808:Blood Vessels / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology*; D011464:Epoprostenol / Q000097:blood* / Q000172:deficiency; D006801:Humans; D007223:Infant; D008833:Microcirculation / Q000503:physiopathology; D012307:Risk Factors; D013928:Thromboxane A2 / Q000097:blood*
D013928:Thromboxane A2; D011464:Epoprostenol
Rol' tromboksana A2 i prostatsiklina v patogeneze sakharnogo diabeta u deteĭ i podrostkov.