title: [Neoadjuvant chemotherapy with cis-platin and 5-fluorouracil in continuous infusion (96 h.), in stages III and IV of carcinomas of the upper aerodigestive tract].
abstract: We have studied 37 patients with advanced head and neck cancer. A combination of Cis-Platinum and 5-Fluorouracil, both administered four days continuously as infusion, was assessed. There were 15 complete responses (40.5%), 15 partial responses (40.5%) and the number of objective responses was 30 (81.5%). Survival is 79.1% at 22 months and none of the patients in complete responses has relapsed during this period.
authors.affiliation: Servicio de ORL, Hospital Clínico Universitario de Salamanca.
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: A G
authors.initials: AG
authors.lastname: Bernal
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: M J
authors.initials: MJ
authors.lastname: Lavilla
authors.forename: A
authors.initials: A
authors.lastname: Martín
authors.forename: J L
authors.initials: JL
authors.lastname: Gómez
authors.forename: J J
authors.initials: JJ
authors.lastname: Cruz
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: A
authors.initials: A
authors.lastname: del Cañizo
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D012074:Remission Induction
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Quimioterapia neoadyuvante con Cis-Platino y 5-Fluoracilo en infusión contínua (96 h.), en los estadíos III y IV de los carcinomas de vías aerodigestivas superiores.