title: Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
abstract: Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed 1H NMR spectroscopic techniques that allow measurement of lactate in vivo, we detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.
authors.affiliation: Department of Neurology, Yale Medical School, New Haven, CT 06510.
authors.forename: J
authors.initials: J
authors.lastname: Prichard
authors.forename: D
authors.initials: D
authors.lastname: Rothman
authors.forename: E
authors.initials: E
authors.lastname: Novotny
authors.forename: O
authors.initials: O
authors.lastname: Petroff
authors.forename: T
authors.initials: T
authors.lastname: Kuwabara
authors.forename: M
authors.initials: M
authors.lastname: Avison
authors.forename: A
authors.initials: A
authors.lastname: Howseman
authors.forename: C
authors.initials: C
authors.lastname: Hanstock
authors.forename: R
authors.initials: R
authors.lastname: Shulman
mesh_terms: D004734:Energy Metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D014785:Vision, Ocular / Q000502:physiology; D014793:Visual Cortex / Q000378:metabolism*; D014796:Visual Perception / Q000502:physiology*
chemical_list: D007773:Lactates