Inhibition of the rate-limiting enzyme in cholesterol biosynthesis leads to up-regulation of the LDL receptor.
D002784:Cholesterol / Q000096:biosynthesis*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology*; D011973:Receptors, LDL / Q000096:biosynthesis*; D015854:Up-Regulation
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011973:Receptors, LDL; D002784:Cholesterol