title: Alteration of four identified K+ currents in Drosophila muscle by mutations in eag.
abstract: Voltage-clamp analysis of Drosophila larval muscle revealed that ether à go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.
authors.affiliation: Department of Biology, University of Iowa, Iowa City 52242.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhong
authors.forename: C F
authors.initials: CF
authors.lastname: Wu
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002874:Chromosome Mapping; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D004558:Electric Stimulation; D007700:Kinetics; D007814:Larva; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000502:physiology*; D009154:Mutation; D015221:Potassium Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011802:Quinidine / Q000494:pharmacology
chemical_list: D015221:Potassium Channels; D015761:4-Aminopyridine; D011802:Quinidine; D002118:Calcium