title: Adult panhypopituitarism presenting as idiopathic growth hormone deficiency in childhood.
abstract: We report two patients who presented in childhood with isolated growth hormone deficiency and in whom progressive loss of anterior function led to panhypopituitarism in early adult life. The need for continued follow-up and reassessment of pituitary function in adult life is stressed in the light of the natural history of these patients.
authors.affiliation: Royal Manchester Children's Hospital, UK.
authors.forename: E C
authors.initials: EC
authors.lastname: Crowne
authors.forename: S M
authors.initials: SM
authors.lastname: Shalet
mesh_terms: D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000097:blood / Q000150:complications*; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007018:Hypopituitarism / Q000097:blood / Q000209:etiology*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D010908:Pituitary Hormones, Anterior / Q000097:blood
chemical_list: D010908:Pituitary Hormones, Anterior; D013006:Growth Hormone; D006854:Hydrocortisone