title: LPS stimulated invertebrate hemocytes: a role for immunoreactive TNF and IL-1.
abstract: Mytilus edulis hemocytes have similarities with vertebrate monocyte/macrophages. We have recently shown that they respond to human TNF and IL-1. We tested the possibility that Mytilus hemocytes produce similar substances in response to LPS. We show that Mytilus hemocytes respond to LPS in a fashion similar to vertebrate monocytes and macrophages and that these responses are inhibited by antibodies to TNF and/or IL-1. These findings are demonstrated both in vitro and in vivo.
authors.affiliation: Department of Microbiology, University of Texas Medical Branch, Galveston 77550.
authors.forename: T K
authors.initials: TK
authors.lastname: Hughes
authors.forename: E M
authors.initials: EM
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Barnett
authors.forename: R
authors.initials: R
authors.lastname: Charles
authors.forename: G B
authors.initials: GB
authors.lastname: Stefano
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000276:immunology*; D006434:Hemocytes / Q000276:immunology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha