The renal growth hormone/insulin-like growth factor I axis.
Collecting duct is a major site of insulin-like growth factor-I (IGF-I) synthesis within kidney. Production of IGF-I at this site is stimulated by growth hormone (GH). IGF-I produced in collecting duct is likely to act on glomerulus and proximal tubule via IGF-I receptors present at these locations. Renal IGF-I may be causative of the glomerular and proximal tubular hypertrophy that occurs in hypersomatotropic states, of compensatory renal hypertrophy, and of renal regeneration following acute ischemic injury.
Hammerman
M R
MR
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
D000818:Animals; D013006:Growth Hormone / Q000502:physiology*; D006984:Hypertrophy / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000502:physiology*; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000254:growth & development* / Q000473:pathology; D007685:Kidney Tubules, Collecting / Q000502:physiology; D051381:Rats; D012038:Regeneration / Q000502:physiology
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone