Effect of chlorpromazine on the toxicity of doxorubicin in mice.
The effect of chlorpromazine (CPZ) on the toxicity of doxorubicin (DOX) were investigated in mice. CPZ significantly enhanced the acute toxicity and bone marrow toxicity induced by DOX. These results suggest the potentiation of DOX toxicity by CPZ is due to increase of sensitivity of mice to DOX.
Shibata
H
H
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Maekawa
I
I
Furusawa
S
S
Kawauchi
H
H
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002746:Chlorpromazine / Q000008:administration & dosage / Q000633:toxicity*; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004351:Drug Resistance; D004357:Drug Synergism; D007928:Lethal Dose 50; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice
D008563:Membrane Lipids; D004317:Doxorubicin; D002746:Chlorpromazine