The effect of neuropeptide Y on voltage-sensitive Ca2+ channels.
Neuropeptide Y (NPY) (50-1000 nM) failed to modify basal or K(+)-stimulated Ca2+ influx in cortical or hippocampal synaptosomes from rat brain, whereas the voltage-sensitive Ca2+ channel (VSCC) blocker Cd2+ (50 microM) caused major inhibition. In cortical synaptosomes from chicken brain NPY (1.0 microM) failed to modify, whereas omega-conotoxin GV1A (0.1 microM) markedly inhibited Ca2+ influx. NPY does not appear to modify synaptosomal Ca2+ influx, however it may still affect VSCCs spatially distinct or 'upstream' from the nerve terminals.
Lundy
P M
PM
Pharmacology and Therapeutics, Defence Research Establishment Suffield, Alberta, Canada.
Frew
R
R
D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002121:Calcium Channel Blockers; D002540:Cerebral Cortex / Q000187:drug effects*; D002645:Chickens; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D009478:Neuropeptide Y / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*; D020960:omega-Conotoxins
D002121:Calcium Channel Blockers; D009478:Neuropeptide Y; D010456:Peptides, Cyclic; D020960:omega-Conotoxins; D002104:Cadmium; C053423:Conus magus toxin