[Renal complications due to non-steroidal anti-inflammatory drugs: mechanism and clinical implications].
1. Despite the fact that the incidence of renal complications due to non-steroidal antiinflammatory drugs (NSAID) is low when compared to their massive utilisation, signs of deteriorating renal function due to the use of NSAID seem to have increased in recent years. 2. Most renal complications are reversed when NSAID are withdrawn. 3. Clinicians should always search for signs of risk situations (decreased effective plasma volume, preexisting renal failure, age, etc.). In these situations, the hydration state should be checked before, and blood creatinine after, the start of therapy.
Wauters
J P
JP
Division de néphrologie, CHUV, Lausanne.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D009318:Natriuresis / Q000187:drug effects; D009395:Nephritis, Interstitial / Q000139:chemically induced; D011188:Potassium / Q000652:urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011188:Potassium
Atteinte rénale sur anti-inflammatoires non stéroïdiens: mécanismes et implications cliniques.