title: The nucleotide sequence of rabbit liver transferrin cDNA.
abstract: The cDNA sequence of rabbit liver transferrin has been determined. The largest cDNA was 2279 base pairs (bp) in size and encoded 694 amino acids consisting of a putative 19 amino acid signal peptide and 675 amino acids of plasma transferrin. The deduced amino acid sequence of rabbit liver transferrin shares 78.5% identity with human liver transferrin and 69.1% and 44.8% identity with porcine and Xenopus transferrins, respectively. At the amino acid level, vertebrate transferrins share 26.4% identity and 56.5% similarity. The most conserved regions correspond to the iron ligands and the anion binding region. Optimal alignment of transferrin sequences required the insertion of a number of gaps in the region corresponding to the N-lobe. In addition, the N-lobes of transferrins share less amino acid sequence similarity than the C-lobes.
authors.affiliation: Department of Biochemistry, University of British Columbia, Vancouver, Canada.
authors.forename: D K
authors.initials: DK
authors.lastname: Banfield
authors.forename: B K
authors.initials: BK
authors.lastname: Chow
authors.forename: W D
authors.initials: WD
authors.lastname: Funk
authors.forename: K A
authors.initials: KA
authors.lastname: Robertson
authors.forename: T M
authors.initials: TM
authors.lastname: Umelas
authors.forename: R C
authors.initials: RC
authors.lastname: Woodworth
authors.forename: R T
authors.initials: RT
authors.lastname: MacGillivray
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D006801:Humans; D007502:Iron Chelating Agents / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013552:Swine; D014168:Transferrin / Q000235:genetics*; D014981:Xenopus
chemical_list: D007502:Iron Chelating Agents; D014168:Transferrin; D004247:DNA