title: Breath-by-breath measurement of oxygen consumption and FIO2-FEO2 with increased oxygen demand.
abstract: Continuous on-line breath-by-breath measurement of pulmonary gas exchange was used to monitor the increase in oxygen uptake (VO2) and carbon dioxide excretion (VCO2) induced by the oxidative phosphorylation uncoupling agent 2, 4-dinitrophenol (DNP) in 10 dogs. With incremental doses of DNP totaling 5 mg/kg, the continuously monitored VO2 increased within 2-3 min after the first injection of the drug. VCO2 showed a similar response 4-6 min after the first injection. Temperature increase due to the pharmacological oxidative phosphorylation uncoupling required 20-30 min for a discernible change at this dose. This study also demonstrated a modified and compromised response to the drug in dogs where oxygen delivery was limited by mechanical ventilation.
authors.affiliation: Department of Anesthesia, Sinai Hospital, Detroit, Michigan.
authors.forename: R E
authors.initials: RE
authors.lastname: Davies
authors.forename: F E
authors.initials: FE
authors.lastname: Noe
authors.forename: A J
authors.initials: AJ
authors.lastname: Whitty
authors.forename: M G
authors.initials: MG
authors.lastname: Busby
authors.forename: K R
authors.initials: KR
authors.lastname: Davies
mesh_terms: D000818:Animals; D003201:Computers; D004140:Dinitrophenols / Q000494:pharmacology*; D004285:Dogs; D008991:Monitoring, Physiologic / Q000379:methods*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*
chemical_list: D004140:Dinitrophenols