The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium.
The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.
Gichner
T
T
Institute of Experimental Botany, Prague, Czechoslovakia.
Holý
A
A
Spassova
M
M
Veleminský
J
J
Grúz
P
P
D000433:1-Propanol / Q000633:toxicity; D000409:Alanine / Q000031:analogs & derivatives / Q000633:toxicity; D000438:Alcohols / Q000633:toxicity; D001386:Azides / Q000633:toxicity*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000633:toxicity; D005643:Fucose / Q000031:analogs & derivatives / Q000633:toxicity; D009005:Monosaccharides / Q000633:toxicity; D009152:Mutagenicity Tests; D009154:Mutation; D010944:Plants / Q000235:genetics; D011409:Propylene Glycols / Q000633:toxicity; D011687:Purines / Q000633:toxicity; D011743:Pyrimidines / Q000633:toxicity; D012486:Salmonella typhimurium / Q000235:genetics
D000438:Alcohols; D001386:Azides; D009005:Monosaccharides; D011409:Propylene Glycols; D011687:Purines; D011743:Pyrimidines; D005643:Fucose; C039309:azidoalanine; D000433:1-Propanol; D003847:Deoxyglucose; D000409:Alanine