[Inhibition of the high-threshold calcium current in hippocampal neurons of rats subjected to intraperitoneal injection of phenylalanine].
Effect of intraperitoneal injection of phenylalanine on the calcium current of hippocampal neurons of rats has been studied by the voltage clamp method of the whole-cell recordings. Calcium currents in hippocampal neurons of control animals after 5-7 days in culture can be separated into two components: low and high voltage-activated ones. The value of high voltage-activated calcium current was 69 +/- 13% at Vt = -10 mV from total calcium inward current in these neurons. High voltage-activated Ica in neurons of phenylalaninemic rats was significantly depressed and its value was 32 +/- 14%, the Vt value being the same. Low voltage-activated calcium current was resistant to intraperitoneal injection of L-phenylalanine.
Martyniuk
A E
AE
Savina
S V
SV
Skibo
G G
GG
D000818:Animals; D002121:Calcium Channel Blockers; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D009474:Neurons / Q000187:drug effects*; D010649:Phenylalanine / Q000097:blood / Q000494:pharmacology*; D051381:Rats
D002121:Calcium Channel Blockers; D010649:Phenylalanine
Podavlenie vysokoporogovogo kal'tsievogo toka v neĭronakh gippokampa krys, podvergnutykh intraperitonal'noĭ in"ektsii fenilalanina.