Effects of MPTP on the cerebrovasculature.
The neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been shown to cause pooling of blood in the brain microvasculature and decrease the permeability of the blood-brain barrier. All areas of the brain examined in this study were affected. This study points out the possibility that reduced nutrient uptake, hypoxia and ensuring free radical damage are involved in the mechanism of toxicity of this neurotoxin.
Adams
J D
JD
School of Pharmacy, University of Southern California, Los Angeles 90033.
Klaidman
L K
LK
Odunze
I N
IN
Johannessen
J N
JN
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D013788:Thalamus / Q000033:anatomy & histology / Q000187:drug effects
D007074:Immunoglobulin G