The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
The present study was to examine the effect on the blood-brain barrier function of a rapid blood pressure elevation and the duration of this pressure during bicuculline and pentylenetetrazol-induced seizures. The experiments were carried out on Wistar rats. Evans blue was used as a blood-brain barrier tracer. Our results showed that the presence of blood pressure increase does not always result in blood-brain barrier leakage during convulsions. Besides the rate of increase in the pressure, the duration of this increased pressure was the important factor in the disruption of blood-brain barrier during bicuculline or pentylenetetrazol-induced seizures.
Oztaş
B
B
Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
Kaya
M
M
D000208:Acute Disease; D000418:Albumins / Q000378:metabolism*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology*; D005070:Evans Blue; D005260:Female; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000033:anatomy & histology; D010433:Pentylenetetrazole; D010539:Permeability; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D013788:Thalamus / Q000033:anatomy & histology
D000418:Albumins; D005070:Evans Blue; D010433:Pentylenetetrazole; D001640:Bicuculline