Natural killer (NK) and lymphokine activated killer (LAK) cell activity in patients (PTS) treated with flavone acetic acid (FAA).
Natural killer (NK) cell activity was measured in nine patients with different solid tumors treated with flavone acetic acid (FAA). In three of them, NK cell activity was significantly increased, in two instances even after repeated courses of treatment. A significant increase in lymphokine activated killer (LAK) cell activity was also observed in three of four patients after in vivo treatment with FAA and in vitro incubation of lymphocytes with recombinant Interleukin-2. We observed some inter-individual variability in drug clearance, but no apparent correlation between drug plasma levels (neither peak nor AUC values) and the effects on NK and LAK activity.
Galligioni
E
E
Centro di Riferimento Oncologico, Aviano (PN), Italy.
Quaia
M
M
Spada
A
A
Crivellari
D
D
Favaro
D
D
Sorio
R
R
Talamini
R
R
D'Incalci
M
M
Allavena
P
P
Damia
G
G
D000276:Adjuvants, Immunologic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D004341:Drug Evaluation; D005260:Female; D005419:Flavonoids / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D012016:Reference Values
D000276:Adjuvants, Immunologic; D005419:Flavonoids; C049328:flavone acetic acid