[Intra-arterial preoperative chemotherapy of advanced cervix cancer].
Three patients suffering from very advanced primary cancers of the cervix uteri (FIGO II B or III B) were treated. By preoperative selective perfusion of both uterine arteries, using cis-platinum alone, a distinct reduction of the tumour volume was achieved. This was demonstrated clinically and also by CAT scan and NMR technique. The elevated serum CEA and SCC levels decreased to normal values. The histomorphology of the Wertheim-Meigs specimens revealed no tumour invasion of the initially infiltrated parametria. This treatment modality has been developed to minimise the toxic side effects of the inductive (neo-adjuvant) chemotherapy for cervical cancers.
Knapstein
P G
PG
Frauenklinik, Johannes-Gutenberg-Universität Mainz.
Kreienberg
R
R
Beck
T
T
Mahlke
M
M
Mitze
M
M
Düber
C
C
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002945:Cisplatin
Intraarterielle präoperative Chemotherapie fortgeschrittener Zervixkarzinome.