[Eosinophilic lesions of the lungs (case reports and review of the literature)].
Overall 75 references concerning the etiology, pathogenesis and the clinical picture of eosinophilic lesions of the lungs were analyzed. Sixteen patients with drug-induced disease were placed under the author's observation. Of these, 8 patients fell ill due to penicillin, 3 to tetracycline, 3 to sulfanilamide intake and alpha to intal inhalations. In 10 patients, pneumonia was characterized by high blood eosinophilia (from 20 to 53%, 37.5 +/- 2.7%) and in 6, it was of moderate nature (from 10 to 15%, 11.8 +/- 0.8%). According to the author's data, the immunopathological response coupled with suppression of the T lymphocyte system, inhibition of the enzymatic activity of leukocytes, dysproteinemias with hypergammaglobulinemia, reductions of the concentration of IgG underlie the disease pathogenesis. In the patients with high blood eosinophilia, including 4 with polysystemic lesions, the disease ran a grave course. The therapeutic effect could only be attained owing to the monotherapy with prednisolone. In the long-term period, 9 patients developed glucocorticoid-dependent bronchial asthma. The patients with moderate blood eosinophilia showed a milder disease course and a favourable outcome.
Trubnikov
G V
GV
D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000209:etiology; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D013601:T-Lymphocytes / Q000276:immunology
D001798:Blood Proteins; D005938:Glucocorticoids; D007074:Immunoglobulin G
K voprosu ob éozinofil'nykh porazheniiakh legkikh.