[Clinical studies of radiation-sensitizing effects of metronidazole in patients with cancer of the uterine body].
The local use of MZ solved in DMSO makes it possible to reach high MZ concentrations (by order 6000-8000 mu g/g) in tumor tissue in the absence of a toxic effect of the drug resulting from its small doses. The results of investigation of radiation pathomorphosis show that the local use of MZ solved in DMSO enhances the damaging effect of radiation on a tumor. Some traits revealed in MZ diffusion (a raised concentration at the serous membrane) must undoubtedly lead to increased efficacy of radiation exposure in zones, responsible for local therapeutic failures. It will permit a considerable increase in the efficacy of radiation therapy of patients with cancer of the uterine body.
Stoliarova
I V
IV
Vinokurov
V L
VL
Zharinov
G M
GM
Val'kovich
A A
AA
Saĭkin
V Kh
VKh
Khanson
K P
KP
D004121:Dimethyl Sulfoxide; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*; D014599:Uterus / Q000378:metabolism
D008795:Metronidazole; D004121:Dimethyl Sulfoxide
Klinicheskie issledovaniia radiosensibiliziruiushchego deĭstviia metronidazola u bol'nykh rakom tela matki.