Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat.
Peripheral administration of cholecystokinin tetrapeptide (CCK-4) at non-sedative doses (25-50 micrograms/kg) decreased the exploratory activity of rats in an elevated plus-maze. This effect was antagonized by treatment with CCK receptor antagonists proglumide (1 and 10 mg/kg), lorglumide (0.1 and 1 mg/kg), L 365,260 (10 micrograms/kg) and devazepide (1 mg/kg). The results suggest that the exploratory behaviour of rats can be altered by pharmacological manipulations at CCK-B receptors.
Harro
J
J
Psychopharmacology Laboratory, Tartu University, Estonia.
Vasar
E
E
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000145:classification / Q000502:physiology*; D013758:Tetragastrin / Q000008:administration & dosage / Q000494:pharmacology
D011949:Receptors, Cholecystokinin; D013758:Tetragastrin