Measurement of PC20 histamine with the use of two different nebulizers and measurement of FEV1 and PEF.
Histamine challenge was performed in 19 patients using two nebulizers (PARI and Wright) and FEV1 and PEF were measured to determine PC20 histamine. FEV1 and PEF gave identical PC20 histamine values. The PARI nebulizer gave PC20 histamine values that were 2.5 doubling concentrations lower than the Wright nebulizer. The reproducibility of histamine challenge with the PARI nebulizer was studied in 15 patients and the results suggested that the challenge was reproducible within one doubling concentration of histamine.
Iversen
M
M
Department of Respiratory Diseases, University Hospital of Aarhus, Denmark.
Harving
H
H
Pedersen
B
B
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D005541:Forced Expiratory Volume; D006632:Histamine / Q000032:analysis*; D006801:Humans; D009330:Nebulizers and Vaporizers; D010366:Peak Expiratory Flow Rate; D015203:Reproducibility of Results; D012220:Rhinitis / Q000503:physiopathology
D006632:Histamine