Anticerebral antibodies in functional psychoses.
Anticerebral antibodies to rabbit brain were investigated by the indirect immunofluorescence method in the sera of 44 schizophrenics and 52 depressives diagnosed according to DSM-III-R, and of 54 healthy volunteers. Four types of staining pattern were observed: type A (nerve cells), type B (blood vessels), type C (nuclei), and type D (glial cells); 34.1% of schizophrenics (27.3% after the absorption with rabbit liver acetone powder) showed type A, as compared with 3.8% (1.9% after the absorption) of depressives and with none of the controls.
Shima
S
S
Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
Yano
K
K
Sugiura
M
M
Tokunaga
Y
Y
D000328:Adult; D000368:Aged; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology; D012559:Schizophrenia / Q000235:genetics / Q000276:immunology*; D012565:Schizophrenic Psychology
D001323:Autoantibodies