[Prevention of reduced plasma fibronectin level in acute and chronic phenol and aniline poisoning in rats on vitamin-rich diet].
Plasma fibronectin, a glycoprotein having a great molecular weight and a quaternary structure is a specific animal protein that maintains the body's homeostasis on exposure to various adverse factors, such as mechanical, thermal or chemical injuries, infection, hemorrhage, intoxication or immune disease. In acute phenol intoxication, fibronectin levels were increased in rats up to 680 mg/l during 48 hours after the onset of priming and decreased up to 240 mg/l during the following 48 hours and then became stable. In acute aniline intoxication, fibronectin concentrations were decreased up to 120-130 mg/l during 4 days, later on its level became higher. The mechanisms responsible for the phenomenon are tentatively outlined. This is an acute phase process in the first case (phenol intoxication) and a stress process in the functioning of the reticuloendothelial system in the other case (aniline intoxication).
Skvortsova
R I
RI
Fedotov
A V
AV
Kharlamova
L A
LA
Ovcharuk
I N
IN
Kuz'mina
L P
LP
D000208:Acute Disease; D000814:Aniline Compounds / Q000506:poisoning*; D000818:Animals; D005353:Fibronectins / Q000097:blood*; D010636:Phenols / Q000506:poisoning*; D051381:Rats
D000814:Aniline Compounds; D005353:Fibronectins; D010636:Phenols; C023650:aniline
Preduprezhdenie snizheniia v plazme krovi urovnia fibronektina pri ostroĭ i khronicheskoĭ intoksikatsii fenolom i anilinom u krys, puluchavshikh v ratsione povyshennoe soderzhanie vitaminov.