title: Quantitative bone and 67Ga scintigraphy in the differentiation of necrotizing external otitis from severe external otitis.
abstract: Qualitative technetium Tc 99m bone scintigraphy using phosphate compounds and gallium 67 scintigraphy were described as a helpful means in diagnosing necrotizing external otitis (NEO). They were, however, claimed to be nonspecific. Quantitative Tc 99m methylene diphosphonate bone scintigraphy and gallium 67 scintigraphy were performed in eight patients with NEO and in 20 patients with severe external otitis, in order to prove usefulness of scintigraphy in the diagnosis of NEO. Ratios of lesion to nonlesion for bone scintigraphy were 1.67 +/- 0.16 in patients with NEO and 1.08 +/- 0.09 in patients with severe external otitis, and for gallium 67 scintigraphy they were 1.35 +/- 0.24 in NEO patients and 1.05 +/- 0.03 in patients with severe external otitis. There was no difference in uptake between diabetic patients with severe external otitis and nondiabetic patients. The scintigraphic studies were also evaluated using a qualitative scoring method (scores 0 to +4), according to the intensity of the radiopharmaceutical uptake. This method was found to be inferior in the diagnosis of NEO compared with the quantitative method. We conclude that lesion-to-nonlesion ratios greater than 1.5 and 1.3 on bone and gallium 67 scintigraphy, respectively, are indicative of NEO. Quantitative bone scintigraphy, which is quicker to perform, may be used as a single imaging modality for the diagnosis of NEO.
authors.affiliation: Department of Otolaryngology, Lady Davis Carmel Hospital, Haifa, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Uri
authors.forename: S
authors.initials: S
authors.lastname: Gips
authors.forename: A
authors.initials: A
authors.lastname: Front
authors.forename: S W
authors.initials: SW
authors.lastname: Meyer
authors.forename: R
authors.initials: R
authors.lastname: Hardoff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003920:Diabetes Mellitus; D003937:Diagnosis, Differential; D005260:Female; D005710:Gallium Radioisotopes; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D015588:Observer Variation; D010032:Otitis Externa / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate; D013701:Temporal Bone / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005710:Gallium Radioisotopes; D013669:Technetium Tc 99m Medronate