In vivo measurements of bone marrow cellularity using volume-localized proton NMR spectroscopy.
Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a total of 25 measurements. These data were compared to cellularity assessments derived from conventional bone marrow core biopsies obtained within a 24-h period before or after the NMR exam. The results obtained by the two methods are well correlated (R = 0.94, P less than 0.001), suggesting that this noninvasive technique may preclude the need for biopsies in some cases.
Ballon
D
D
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Jakubowski
A
A
Gabrilove
J
J
Graham
M C
MC
Zakowski
M
M
Sheridan
C
C
Koutcher
J A
JA
D000328:Adult; D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006402:Hematologic Diseases / Q000628:therapy; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use; D006801:Humans; D007085:Ilium / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy
D016298:Hematopoietic Cell Growth Factors