title: Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL).
abstract: Antiglobulin test (AT) and Dixon tests were performed in 100 patients with CLL. Thirty-five of them had Rai stages 0 or 1, 19 stage 2, 13 stage 3, and 33 stage 4. Twelve patients showed red blood cells autoantibodies (RBCAb) positivity; positivity at Dixon test (direct, indirect, or both) was observed in 74%. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are considered risk factors, independently of the presence of an autoimmune disorder. Nine RBCAb positive patients with positive Dixon test had the worst survival curves, 5 of these were anemic and 1 thrombocytopenic and anemic.
authors.affiliation: Human Biopathology Dept., University La Sapienza, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Rossi
authors.forename: L
authors.initials: L
authors.lastname: Granati
authors.forename: G
authors.initials: G
authors.lastname: Girelli
authors.forename: G
authors.initials: G
authors.lastname: Gandolo
authors.forename: P
authors.initials: P
authors.lastname: Perrone
authors.forename: M
authors.initials: M
authors.lastname: Martelli
authors.forename: L
authors.initials: L
authors.lastname: Conti
authors.forename: R
authors.initials: R
authors.lastname: Marini
authors.forename: D
authors.initials: D
authors.lastname: Pastorelli
authors.forename: S
authors.initials: S
authors.lastname: Coluzzi
authors.forename: P
authors.initials: P
authors.lastname: Niscola
authors.forename: F
authors.initials: F
authors.lastname: Pizzo
authors.forename: F
authors.initials: F
authors.lastname: Mandeli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D001789:Blood Group Antigens / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000401:mortality; D008297:Male; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D001323:Autoantibodies; D001789:Blood Group Antigens