Prospective assessment of cardiac function in patients with Kaposi's sarcoma and the acquired immune deficiency syndrome.
Prospective evaluation of cardiac function was undertaken in 21 patients with Kaposi's sarcoma (KS) and the acquired immune deficiency syndrome (AIDS) as part of a phase II clinical trial of 4'epirubicin. All patients were homosexual or bisexual males of median age 34 years (range 23-65). All patients had disseminated cutaneous involvement by KS and seven had systemic organ involvement. No patient had a history of cardiac symptoms, and physical examination of the cardiovascular system was within normal limits for all patients. The baseline ECG was normal in only nine patients (45%). Five had non-specific S-T segment and T-wave changes. Two had poor R-wave progression, and one patient each had incomplete right bundle branch block, left axis deviation, and voltage criteria suggestive of left ventricular hypertrophy. Radionuclide angiography was performed on all patients and compared to 12 age-matched, low-likelihood male controls. The mean ejection fraction (EF) at rest was 61.0 +/- 8.4%, and was not significantly different from the normal control value of 62.4 +/- 7.0%. Similarly the EF during exercise was 66.7 +/- 5.0%, again not significantly different from the control value of 67.8 +/- 5.8%. A drop in EF during exercise was seen in five of 15 KS patients compared to three of 12 controls. Chamber size was normal for both ventricles in only 14 patients (67%) with right ventricular dilatation seen in seven patients (33%). Wall motion abnormalities were also seen in nine patients (42.9%), with the right ventricle affected in eight patients (38.1%), chiefly involving the apex. No chamber size or wall motion abnormalities were seen in the control patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Herst
J A
JA
Department of Medicine, Toronto General Hospital, Ontario.
Shepherd
F A
FA
Liu
P
P
Butany
J W
JW
Houle
S
S
Burkes
R
R
Paul
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005080:Exercise Test; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology; D009206:Myocardium / Q000473:pathology; D010493:Pericarditis / Q000209:etiology; D011446:Prospective Studies; D011875:Radionuclide Angiography; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000503:physiopathology*; D013318:Stroke Volume