Analysis of genes and chromosomes by nonisotopic in situ hybridization.
Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.
Lichter
P
P
Institute for Viral Research, German Cancer Research Center, Heidelberg.
Boyle
A L
AL
Cremer
T
T
Ward
D C
DC
D002874:Chromosome Mapping / Q000379:methods*; D005456:Fluorescent Dyes; D005796:Genes; D015336:Molecular Probe Techniques; D009693:Nucleic Acid Hybridization; D009711:Nucleotides / Q000032:analysis; D012815:Signal Processing, Computer-Assisted
D005456:Fluorescent Dyes; D009711:Nucleotides