On the relation between cerebral cysteinyl-leukotriene formation and epileptic seizures.
In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha. By contrast, in rats injected with pentylenetetrazole or bicuculline very large amounts of PGF2 alpha but no cysteinyl-LT could be detected in the brain tissues. The data indicate that at least in rats the extensive neuronal activity during tonic-clonic convulsions is not necessarily sufficient for the activation of the 5-lipoxygenase pathway. Apparently important species differences do exist.
Simmet
T
T
Department of Pharmacology and Toxicology, Ruhr-University Bochum, Germany.
Tippler
B
B
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D015237:Dinoprost / Q000096:biosynthesis*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005849:Gerbillinae; D006234:Handling, Psychological; D007700:Kinetics; D010433:Pentylenetetrazole / Q000494:pharmacology; D013189:SRS-A / Q000031:analogs & derivatives* / Q000096:biosynthesis; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism
D013189:SRS-A; D015237:Dinoprost; D010433:Pentylenetetrazole; D001640:Bicuculline