title: [Simultaneous assessment of wall motion and myocardial perfusion by technetium-99m methoxy isobutyl isonitrile].
abstract: The aim of this study was to assess whether or not myocardial uptake of Technetium-99m methoxy isobutyl isonitrile (Tc-MIBI) indicated myocardial viability. We performed simultaneous Tc-MIBI angiography and myocardial SPECT at rest on 12 patients with suspected coronary artery disease. Left ventricle was divided into 3 segments, and regional wall motion was graded as normal, hypokinesis and akinesis/dyskinesis. Myocardial uptake of Tc-MIBI was assessed as normal, reduced and absent in each segment. In segments with normal and reduced Tc-MIBI uptake, 7% (2 of 28) and 33% (2 of 6) showed wall motion abnormalities of akinesis/dyskinesis, respectively. However, all segments with absent Tc-MIBI uptake had asynergy of akinesis/dyskinesis (2 of 2, 100%). Myocardial Tc-MIBI uptake at rest indicated wall motion abnormalities and was considered to be useful for the evaluation of myocardial viability. First-pass radionuclide angiography followed by myocardial SPECT with Tc-MIBI demonstrated to be useful for the simultaneous assessment of the left ventricular wall motion and myocardial perfusion.
authors.affiliation: First Department of Internal Medicine, Department of Radiology, Yamagata University Hospital, Yamagata University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeishi
authors.forename: I
authors.initials: I
authors.lastname: Tono-Oka
authors.forename: M
authors.initials: M
authors.lastname: Meguro
authors.forename: J
authors.initials: J
authors.lastname: Chiba
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Tsuiki
authors.forename: A
authors.initials: A
authors.lastname: Komatani
authors.forename: M
authors.initials: M
authors.lastname: Kera
authors.forename: I
authors.initials: I
authors.lastname: Takanashi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi; D014022:Tissue Survival; D015899:Tomography, Emission-Computed, Single-Photon; D015646:Ventriculography, First-Pass
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi