title: Glutathione levels during thermal induction of the yeast-to-mycelial transition in Candida albicans.
abstract: Glutathione (GSH) levels were directly monitored by reverse phase HPLC during the thermal yeast-to-mycelial induction of Candida albicans. The GSH levels decreased approximately 100-fold within 120 min which corresponded to the time of maximal yeast-to-mold conversion. The yeast to mold conversion was inhibited by 1-p-chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one (CDDP), a thiol-specific alkylator, which prevented the decline in GSH levels. These results are discussed with respect to the potential involvement of intracellular GSH levels in regulation of the yeast-to-mold dimorphism in Candida albicans.
authors.affiliation: Department of Biological Sciences, University of Windsor, Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: K
authors.initials: K
authors.lastname: Klein
authors.forename: E
authors.initials: E
authors.lastname: Manavathu
authors.forename: J R
authors.initials: JR
authors.lastname: Dimmock
authors.forename: B
authors.initials: B
authors.lastname: Mutus
mesh_terms: D002176:Candida albicans / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism*; D007700:Kinetics; D013696:Temperature; D013997:Time Factors
chemical_list: D005978:Glutathione