title: Phytogrowth-inhibitory and antimicrobial activities of 3,4'-dihydroxy-alpha,beta-diethylstilbene, the isomer of diethylstilbestrol.
abstract: 3,4'-Dihydroxy-alpha,beta-diethylstilbene (I), like diethylstilbestrol (II), showed phytogrowth-inhibitory and antimicrobial activities. First, compound I showed strong growth-inhibitory activity against the roots of two kinds of plants. The inhibitory activity of I was almost equal to that of sodium 2,4-dichlorophenoxyacetate used as a positive control. The phytogrowth-inhibitory activity of I was much higher than that of II. Next, unlike II, I had broad antifungal spectrum against phathogenic fungi. Compound I showed antifungal activity against six kinds of Fusarium oxysporum sp. This compound also had antibacterial activity against pathogenic and plant-pathogenic bacteria. These antibacterial activities of I were as high as those of II, the isomer of I. It should be emphasized that by shifting one of the phenolic hydroxyl groups of II to meta-position, phytogrowth-inhibitory activity was largely increased, while antimicrobial activity was unchanged.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inamori
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Nishiguchi
authors.forename: S
authors.initials: S
authors.lastname: Koyama
authors.forename: H
authors.initials: H
authors.lastname: Tsujibo
authors.forename: Y
authors.initials: Y
authors.lastname: Miki
authors.forename: S
authors.initials: S
authors.lastname: Takemura
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010937:Plant Growth Regulators; C069314:3,4'-dihydroxy-alpha,beta-diethylstilbene; D004054:Diethylstilbestrol