title: High-dose folinic acid, 5-fluorouracil bolus and continuous infusion in poor-prognosis patients with advanced measurable gastric cancer.
abstract: Twenty-five patients with advanced measurable gastric cancer were treated with high-dose folinic acid (200 mg/m2), 5-fluorouracil bolus (400 mg/m2) and continuous infusion (600 mg/m2) for two consecutive days every two weeks. Fourteen patients over 65 yr old and/or with a poor general status received first-line treatment, and eleven younger patients second-line. The response rate was 43.5% in 23 evaluable patients. There were 2 complete responses (8.7%) and 8 partial responses (34.8%). Median survival was 6 months in first-line and 8 months, calculated from start of folinic acid-5FU, in second-line. Toxicity was mild without WHO Grade greater than 2 events. This combination is effective for advanced gastric cancer in poor-prognosis patients and requires further studies.
authors.affiliation: GERCOD Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs, Hôpital Saint-Antoine, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Louvet
authors.forename: A
authors.initials: A
authors.lastname: de Gramont
authors.forename: B
authors.initials: B
authors.lastname: Demuynck
authors.forename: B
authors.initials: B
authors.lastname: Nordlinger
authors.forename: J E
authors.initials: JE
authors.lastname: Maisani
authors.forename: B
authors.initials: B
authors.lastname: Lagadec
authors.forename: S
authors.initials: S
authors.lastname: Delfau
authors.forename: C
authors.initials: C
authors.lastname: Varette
authors.forename: G
authors.initials: G
authors.lastname: Gonzalez-Canali
authors.forename: M
authors.initials: M
authors.lastname: Krulik
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000556:secondary; D010534:Peritoneal Neoplasms / Q000556:secondary; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality
chemical_list: D002955:Leucovorin; D005472:Fluorouracil