Thrombocytosis in adults: analysis of 777 patients.
A total of 777 patients with thrombocytosis, defined as a platelet count of greater than 500 x 10(9)l-1, seen in a University hospital over a 1-year period, were studied prospectively for aetiology. The most frequent causes of thrombocytosis were infection (21.9%), rebound thrombocytosis (19.4%), tissue damage (17.9%), chronic inflammatory disorders (13.1%) and malignancy (5.9%). Thrombocytosis associated with multiple causative factors, occurring simultaneously, was seen in 6.1% of cases. Thrombocytosis of greater than or equal to 1 million x 10(9)l-1 was found most frequently in patients with multiple aetiological factors occurring at the same time, in myeloproliferative disorders, or in postsplenectomy patients.
Santhosh-Kumar
C R
CR
Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Yohannan
M D
MD
Higgy
K E
KE
al-Mashhadani
S A
SA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010976:Platelet Count; D011446:Prospective Studies; D012008:Recurrence; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D013922:Thrombocytosis / Q000097:blood / Q000209:etiology*