title: Effects of hyperventilation on prostacyclin formation and on pulmonary vasodilation after group B beta-hemolytic streptococci-induced pulmonary hypertension.
abstract: Prostacyclin is released during hyperventilation (HV); however, its role as mediator of HV-induced pulmonary vasodilation remains controversial. We have investigated this by studying the effects of HV on pulmonary artery pressure (PAP) in otherwise normal lungs versus lungs vasoconstricted with group B streptococci (GBS), with and without prior prostacyclin synthesis inhibition. Two- to 3-wk-old piglets were given tranylcypromine, a prostacyclin synthetase inhibitor (n = 6), or placebo (n = 6). Animals were mechanically ventilated normally, then hyperventilated (PCO2 1.5 +/- 0.2 kPa) and then returned to normal ventilation. After each 30-min segment, plasma 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) (prostacyclin hydrolysis product) levels and PAP were measured. Then GBS infusions were administered to both groups to induce pulmonary hypertension. With GBS, the normal ventilation/hyperventilation/normal ventilation protocol was repeated as above.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Newborn Medicine, University of Chicago Medical Center, Illinois 60637.
authors.forename: C
authors.initials: C
authors.lastname: Hammerman
authors.forename: M J
authors.initials: MJ
authors.lastname: Aramburo
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D011464:Epoprostenol / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D006985:Hyperventilation / Q000503:physiopathology*; D008168:Lung / Q000378:metabolism; D011651:Pulmonary Artery / Q000503:physiopathology*; D013290:Streptococcal Infections / Q000150:complications; D013292:Streptococcus agalactiae / Q000472:pathogenicity; D013552:Swine; D014664:Vasodilation / Q000502:physiology
chemical_list: D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol