title: Possible alteration of the blood-brain barrier by boron-neutron capture therapy.
abstract: In the course of re-assessment of boron-neutron capture therapy (BNCT) for malignant brain tumors, fractionation of neutron irradiation has been proposed. The authors have used BNCT with a single fraction technique during the past 21 years and now decided to study some effects of fractionation. Twenty-two healthy mouse brains were irradiated with thermal neutrons after boron-10 injection (mercaptoundecahydrododecaborate). A second dose of boron-10 was administered and its uptake in the boron-neutron-capture-irradiated brains was determined. A tendency towards increased boron uptake in the moderately BNCT-treated brains was noticed, which may result in increased brain damage if fractionated neutron irradiation is used.
authors.affiliation: Department of Neurosurgery, Teikyo University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hatanaka
authors.forename: M
authors.initials: M
authors.lastname: Moritani
authors.forename: M
authors.initials: M
authors.lastname: Camillo
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001895:Boron / Q000097:blood; D007554:Isotopes; D008297:Male; D051379:Mice; D009502:Neutrons; D011878:Radiotherapy / Q000379:methods*
chemical_list: D007554:Isotopes; D001895:Boron