title: Synthesis and schistosomicidal activity of 4-methyl-5-(aryl vinyl)-1,2-dithiole-3-thiones.
abstract: The synthesis of vinylogous of 1,2-dithiole-3-thione is described. The activity in experimental schistosomiasis (schistosomicidal activity) was tested with mice infected with Schistosoma mansoni. The reference compound was 4-methyl-5-(pyrazinyl)-1,2-dithiole-3-thione (oltipraz).
authors.affiliation: Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Université de Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Abdaly
authors.forename: C
authors.initials: C
authors.lastname: Vaccher
authors.forename: P
authors.initials: P
authors.lastname: Berthelot
authors.forename: M
authors.initials: M
authors.lastname: Debaert
authors.forename: M
authors.initials: M
authors.lastname: Luyckx
authors.forename: S
authors.initials: S
authors.lastname: Deblock
mesh_terms: D000818:Animals; D005260:Female; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012550:Schistosoma mansoni / Q000187:drug effects*; D012552:Schistosomiasis / Q000188:drug therapy / Q000469:parasitology; D012556:Schistosomicides / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D012556:Schistosomicides