Antitrypsin phenotypes in occupational organic diisocyanate asthma.
Eleven subjects with clinical bronchial hyperreactivity towards hexamethylene diisocyanate used in their work and verified by spirometry before and after a shift were screened for their antitrypsin phenotypes by isoelectric focusing. One third were M1M1 homozygotes (over 50% in controls) while the rest were heterozygotes comprising one case, each, of M1S and M1I (expected frequencies 5 and 0.5%, respectively). It seems that heterozygous alpha 1-antitrypsin carriers may be at a greater risk to develop a pulmonary disease in the organic diisocyanate exposure than the homozygotes.
Savolainen
H
H
IUMHT, Lausanne, Switzerland.
D001249:Asthma / Q000139:chemically induced* / Q000235:genetics; D003485:Cyanates / Q000633:toxicity*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000235:genetics; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D003485:Cyanates; D000515:alpha 1-Antitrypsin