title: Independent oxygen uptake and oxygen delivery in septic and postoperative patients.
abstract: Previous studies reporting pathologic oxygen supply dependency calculated VO2 as CO x C(a-v)O2. We investigated whether pathologic oxygen supply dependency exists in septic and postoperative patients if VO2 and DO2 are assessed independently. In septic patients, VO2 was 164 +/- 31 and DO2 was 633 +/- 209 ml/min/m2. The slope (b) of the VO2-DO2 regression line VO2 = b x DO2 + a ranged from -0.10 to 0.08 (mean, 0.02 +/- 0.01, p less than 0.05) and was statistically significant in two patients (b = 0.05 and b = 0.08, p less than 0.05). In postoperative patients VO2 was 136 +/- 19 and DO2 was 481 +/- 160 ml/min/m2; b ranged from -0.07 to 0.09 (mean, 0.04 +/- 0.01, p less than 0.001) and was statistically significant in one patient (b = 0.09, p less than 0.01). The lack of a close relationship between independently measured VO2 and DO2 may indicate that septic and postoperative patients in stable hemodynamic condition have no pathologic oxygen supply dependency. Analysis of the VO2-DO2 relationship may not be useful to guide therapy or predict outcome.
authors.affiliation: Department of General Surgery, University Hospital Dijkzigt, Rotterdam, The Netherlands.
authors.forename: C G
authors.initials: CG
authors.lastname: Vermeij
authors.forename: B W
authors.initials: BW
authors.lastname: Feenstra
authors.forename: W J
authors.initials: WJ
authors.lastname: Adrichem
authors.forename: H A
authors.initials: HA
authors.lastname: Bruining
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007239:Infections / Q000378:metabolism* / Q000503:physiopathology; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D013514:Surgical Procedures, Operative
chemical_list: D010100:Oxygen