Solid-phase extraction of fluoxetine and norfluoxetine from serum with gas chromatography-electron-capture detection.
A rapid, selective, and sensitive method is described for the purification and analysis of fluoxetine and norfluoxetine using a solid-phase extraction column and gas chromatography-electron-capture detection. Linear quantitative response curves for fluoxetine and norfluoxetine are generated over a concentration range of 20-200 ng/ml. Overall extraction efficiency of the extraction procedure is found to be greater than 90% and greater than 75% with correlation coefficients of 0.997 and 0.993 for fluoxetine and norfluoxetine, respectively.
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Varian Sample Preparation Products, Harbor City, CA 90710.
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D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans
D005473:Fluoxetine; C036139:norfluoxetine