title: Hydrophobicity-dependent fluorescence properties and intracellular fluorospectroscopic behavior of phototoxic drugs.
abstract: Fluorospectroscopic behavior of chlorpromazine, mequitazine, afloqualone and piroxicam, which are known to induce skin photosensitivity, was examined in both homogeneous solutions and human buccal mucosal cells. Each drug showed large Stokes' shifts and their fluorescence intensities increased in hydrophobic solvents. These results indicated that the drugs tested can be used as hydrophobic fluorescence probes. Fluorescence microscopic observations of buccal mucosal cells treated with these drugs showed that all the drugs, especially chlorpromazine and mequitazine, were distributed in intracellular membranous regions.
authors.affiliation: Institute of Research and Development, Tokai University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: I
authors.initials: I
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Fujita
mesh_terms: D002746:Chlorpromazine / Q000032:analysis / Q000737:chemistry; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D009061:Mouth Mucosa / Q000166:cytology*; D010640:Phenothiazines / Q000032:analysis / Q000737:chemistry; D010894:Piroxicam / Q000032:analysis / Q000737:chemistry; D011799:Quinazolines / Q000032:analysis / Q000737:chemistry; D011838:Radiation-Sensitizing Agents / Q000032:analysis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D010640:Phenothiazines; D011799:Quinazolines; D011838:Radiation-Sensitizing Agents; D010894:Piroxicam; C033541:afloqualone; D002746:Chlorpromazine; C006069:mequitazine