Possible alteration of the blood-brain barrier by boron-neutron capture therapy.
In the course of re-assessment of boron-neutron capture therapy (BNCT) for malignant brain tumors, fractionation of neutron irradiation has been proposed. The authors have used BNCT with a single fraction technique during the past 21 years and now decided to study some effects of fractionation. Twenty-two healthy mouse brains were irradiated with thermal neutrons after boron-10 injection (mercaptoundecahydrododecaborate). A second dose of boron-10 was administered and its uptake in the boron-neutron-capture-irradiated brains was determined. A tendency towards increased boron uptake in the moderately BNCT-treated brains was noticed, which may result in increased brain damage if fractionated neutron irradiation is used.
Hatanaka
H
H
Department of Neurosurgery, Teikyo University, Tokyo, Japan.
Moritani
M
M
Camillo
M
M
D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001895:Boron / Q000097:blood; D007554:Isotopes; D008297:Male; D051379:Mice; D009502:Neutrons; D011878:Radiotherapy / Q000379:methods*
D007554:Isotopes; D001895:Boron