Elution of anti-Zwa (-PIA1) from autologous platelets after normalization of platelet count in post-transfusion purpura.
In two patients suffering from post-transfusion purpura, anti-Zwa was demonstrated in either eluates from autologous platelets harvested during the remission phase and after normalization of the platelet count. In both patients, platelet-associated immunoglobulin (PAIg) was demonstrated during the acute phase. PAIg disappeared concomitantly with recovery and, thus, seems to be associated with the thrombocytopenia. These data support the assumption that immunocomplexes are adsorbed nonspecifically to the platelets and cause destruction of autologous platelets lacking the corresponding antigen. An association between the IgG3 subclass of anti-Zwa antibodies and the destruction of autologous platelets was also seen.
Taaning
E
E
Department of Clinical Immunology and Blood Bank, Glostrup Hospital, Denmark.
Skov
F
F
D000368:Aged; D000369:Aged, 80 and over; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D039661:Integrin beta3; D007518:Isoantibodies / Q000276:immunology / Q000302:isolation & purification*; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000276:immunology*; D011696:Purpura, Thrombocytopenic / Q000209:etiology* / Q000276:immunology; D065227:Transfusion Reaction
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens; D010980:Platelet Membrane Glycoproteins