title: Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig.
abstract: We have studied the effects of tachykinin-depletion on airway microvascular leakage induced by allergen challenge in ovalbumin-sensitised guinea pigs. Tachykinin-depletion was obtained by capsaicin pretreatment 1 week before inhaled allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Thus, sensory neuropeptides may not be important in allergen-induced acute airway microvascular leakage in guinea pig in vivo.
authors.affiliation: Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
authors.forename: J O
authors.initials: JO
authors.lastname: Lötvall
authors.forename: K P
authors.initials: KP
authors.lastname: Hui
authors.forename: C G
authors.initials: CG
authors.lastname: Löfdahl
authors.forename: P J
authors.initials: PJ
authors.lastname: Barnes
authors.forename: K F
authors.initials: KF
authors.lastname: Chung
mesh_terms: D000402:Airway Obstruction / Q000378:metabolism / Q000517:prevention & control; D000485:Allergens; D000818:Animals; D002199:Capillary Permeability; D002211:Capsaicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D015320:Tachykinins / Q000378:metabolism; D014132:Trachea / Q000098:blood supply / Q000378:metabolism
chemical_list: D000485:Allergens; D015320:Tachykinins; D002211:Capsaicin