[The role of androgens in the regulation of the immune response in male CBA mice at various stages of ontogenesis].
Gonadectomy of 18-day-old mice (the 1st group) causes retardation of the functional maturation of the immune system but that of 1 and 3-month-old mice (the 2nd group), on the contrary, intensifies the immune response. The treatment of the 1st group mice during 10 days with 5-alpha-DHT (100 micrograms/100 g b. w.) increases the immune response 1 month after the end of hormone therapy more than twice. The TP failed to evoke such effects. In the 2-nd group of mice TP as well as 5-alpha-DHT (10 micrograms, 100 micrograms) caused the same stimulatory effects and the TP (8 mg) and 5-alpha-DHT (3 mg)-decreased the immune response. The diverse effects of the TP and 5-alpha-DHT in immature and mature mice may be due to the age peculiarities of androgens metabolism.
Nikonenko
I R
IR
Zelenskaia
T M
TM
D000276:Adjuvants, Immunologic; D000367:Age Factors; D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology*; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*
D000276:Adjuvants, Immunologic; D013196:Dihydrotestosterone; D013739:Testosterone
Rol' androgenov v reguliatsii immunnogo otveta u mysheĭ-samtsov linii CBA na razlichnykh étapakh ontogeneza.