Inhibition of mammalian adenosine deaminase by novel functionalized 2',3'-dideoxyadenosines.
2',3'-Dideoxyadenosine (ddA) analogues with a variety of functionalization at the 2-position have been synthesized by a combination of thermal, photochemical and metal-mediated methodologies. These compounds are either totally resistant to deamination by mammalian adenosine deaminase (ADA) or are very poor substrates of ADA. They are competitive inhibitors of this enzyme.
Nair
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Department of Chemistry, University of Iowa, Iowa City 52242.
Buenger
G S
GS
Sells
T B
TB
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D002417:Cattle; D016048:Dideoxyadenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet
D058892:Adenosine Deaminase Inhibitors; D016048:Dideoxyadenosine