Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons.
In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.
Surmeier
D J
DJ
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Stefani
A
A
Foehring
R C
RC
Kitai
S T
ST
D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000254:growth & development*; D004594:Electrophysiology; D004622:Embryo, Mammalian / Q000378:metabolism; D005260:Female; D007700:Kinetics; D009474:Neurons / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
D015221:Potassium Channels