[Radiosurgical combination for the treatment of soft tissue sarcoma of the extremities].
From January 1979 to December 1987, 99 patients with a diagnosis of localized soft-tissue sarcoma of the extremities received preoperative radiation therapy (50 patients) or postoperative irradiation (49 cases). In the preoperative RT group, doses ranged from 42 Gy/14 fractions to 51 Gy/17 fractions; the patients treated with postoperative radiation therapy received 46 Gy/23 fractions. The surgical procedure was in each patient complete resection of the mass with preservation of the affected limb. The main cause of failure were distant metastases (33.3%). The incidence of local recurrences was low (7.1%). Recurrences were related to tumor size [less than 5 cm: 0/12; 5-10 cm: 2/45 (2.3%; greater than 10 cm: 5/42 (11.9%)]. The incidence of distant metastases was higher in the group treated with preoperative radiation therapy (44% versus 22.4%), probably because a higher percentage of patients in this group had large tumors. Late complications were analyzed in 59 patients with a follow-up longer than 24 months. Severe complications rate was low (6/59 cases, 10.1%), and higher in the preoperative than in the postoperative RT group (15.4% versus 6.1%), which is probably related to the different fractionations administered.
Frezza
G
G
Istituto di Radioterapia L. Galvani, Università, Bologna.
Ammendolia
I
I
Barbieri
E
E
Corsa
P
P
Neri
S
S
Putti
C
C
Veraldi
A
A
Babini
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001132:Arm; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011878:Radiotherapy / Q000009:adverse effects; D012509:Sarcoma / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
L'associazione radiochirurgica nel trattamento dei sarcomi delle parti molli delle estremità.