Reduction in sella turcica volume. An effect of long-term treatment with the somatostatin analogue, SMS 201-995, in acromegalic patients.
Ten patients with acromegaly were treated with the long-acting somatostatin analogue, Sandostatin (SMS 201-995, octreotide) for more than one year. Computerized tomography was performed before and on 4 different occasions during the treatment. Sella turcica volumes were calculated in nine patients and showed a gradual decrease in all, averaging 32% +/- 14.6%, P less than 0.001 at the end of the study, which is probably indicative of a simultaneous reduction in adenoma size.
Lund
E
E
Diagnostic Radiology Department, Aarhus Kommunehospital, Denmark.
Jørgensen
J
J
Christensen
S E
SE
Weeke
J
J
Orskov
H
H
Harris
A G
AG
D000172:Acromegaly / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D012658:Sella Turcica / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
D013006:Growth Hormone; D015282:Octreotide