title: Evaluation of a new calcium containing cardioplegic solution in the isolated rabbit heart in comparison to a calcium-free, low sodium solution.
abstract: Isolated perfused rabbit hearts were studied to compare the effects of 3 hour ischemic arrest following either calcium-free or calcium-containing cardioplegia, on the recovery of isovolumic function of the left ventricle, coronary flow, release of creatine phosphokinase and myocardial water content. The hearts perfused with the calcium-containing solution (Ca 0.5 mmol/L) showed better recovery of the developed pressure in the left ventricle, and its first derivative and compliance. Coronary flow at a constant perfusion pressure was better restored during reperfusion in the hearts with calcium-containing solution. The release of less CPK and a lower water content were also observed in the hearts reperfused with calcium-containing solution. We concluded that calcium-containing cardioplegic solution with a high concentration of magnesium (10 mmol/L) was superior to calcium-free solution for myocardial protection.
authors.affiliation: First Department of Surgery, Yamaguchi University School of Medicine, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Noda
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Tsuboi
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Esato
authors.forename: A
authors.initials: A
authors.lastname: Imamura
authors.forename: S
authors.initials: S
authors.lastname: Kawahara
authors.forename: J
authors.initials: J
authors.lastname: Uchiyama
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D003326:Coronary Circulation / Q000502:physiology; D006324:Heart Arrest, Induced; D008274:Magnesium / Q000494:pharmacology; D015425:Myocardial Reperfusion; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D002314:Cardioplegic Solutions; D012964:Sodium; D008274:Magnesium; D002118:Calcium