[Effect of intravenous human immunoglobulins on bacterial clearance and mortality in experimental Escherichia coli K 1 septicemia in chicken].
The antibacterial effect of intravenous immune globulins (IVIG) was tested in 4 to 6-week-old chickens experimentally infected with a K1 E. coli strain from a neonate with meningitis. Following inoculation of 10(7) E. coli K1 per animal, the chickens were randomized to receive a placebo, 0.25 g/kg, 0,50 g/kg or 1 g/kg of intravenous immune globulins. Injections were performed 4 hours after the bacterial inoculation. Numbers of animals in each group were 30, 19, 30 and 10 for 6-week-old chickens and 9, 10, 9 and 0 for 4-week-old chickens. Bacterial diffusion was evaluated using quantitative cultures of blood from breast capillaries. In the 6-week-old chickens given 0.25 g/kg or 0.50 g/kg of intravenous immune globulins, bacteremia 48 hours after inoculation and mortality were significantly lower than in the placebo group. Administration of intravenous immune globuline in a dose of 1.0 g/kg, however, was followed by increased blood bacteria counts 48 and 72 hours after inoculation. In the 4-week-old chickens, no reduction in bacterial counts or improvement in survival was seen after administration of intravenous immune globulins. These data should provide a basis for a more rational use of intravenous immune globulins in neonates and children.
Labarthe
J C
JC
Clinique du Tertre Rouge, Le Mans, France.
Guillot
J F
JF
Mouline
C
C
Brée
A
A
D000818:Animals; D002645:Chickens; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000401:mortality; D007136:Immunoglobulins / Q000008:administration & dosage / Q000276:immunology*; D007275:Injections, Intravenous; D018805:Sepsis / Q000382:microbiology* / Q000401:mortality
D007136:Immunoglobulins
Effet des immunoglobulines humaines intraveineuses sur la clearance bactérienne et la mortalité lors de septicémies expérimentales à Escherichia coli K 1 chez le poulet.