Incidence of multiple sclerosis in Hordaland, western Norway: a fluctuating pattern.
The incidence of multiple sclerosis (MS) was studied in the county of Hordaland, western Norway. A significant increase in incidence in the period 1958-1987, a decline followed by a gradual increase in mean age at onset, geographic differences in time trends and a biphasic pattern revealed by a birth cohort analysis support the theory of real time-space fluctuations in the incidence of MS over time.
Grønning
M
M
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Riise
T
T
Kvåle
G
G
Nyland
H
H
Larsen
J P
JP
Aarli
J A
JA
D000328:Adult; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D009103:Multiple Sclerosis / Q000145:classification / Q000453:epidemiology* / Q000209:etiology; D009664:Norway / Q000453:epidemiology; D012307:Risk Factors; D012424:Rural Population; D014505:Urban Population