title: Improvement of scleromyxedema associated with isotretinoin therapy.
abstract: The treatment of scleromyxedema has been largely ineffective. We report improvement of scleromyxedema with myopathy after treatment with isotretinoin, 40 mg twice a day. We review other therapeutic modalities used for this disorder and discuss properties of isotretinoin that may have contributed to the favorable response.
authors.affiliation: Dermatology Service, Veterans Administration Medical Center, Allen Park, MI 48226.
authors.forename: B M
authors.initials: BM
authors.lastname: Hisler
authors.forename: L B
authors.initials: LB
authors.lastname: Savoy
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D005148:Facial Dermatoses / Q000473:pathology; D006229:Hand Dermatoses / Q000473:pathology; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D009135:Muscular Diseases / Q000473:pathology; D009230:Myxedema / Q000188:drug therapy* / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015474:Isotretinoin