title: [Coronary reserve determination by intracoronary papaverine: effects of various doses on coronary circulation and hemodynamics].
abstract: In 40 male coronary patients during heart catheterization the coronary flow reserve was investigated by continuous thermodilution in the coronary sinus after intracoronary papaverine application. Simultaneously a number of heart function parameters were recorded. Already the lowest dosage of papaverine (5 mg) was able to induce a maximal flow acceleration. Higher dosages were accompanied with haemodynamic side effects (increase of heart rate and left ventricular end-diastolic pressure, decrease of left ventricular systolic pressure, appearance of myocardial ischemia) without further increase of coronary flow. After at most 5 minutes time the papaverine effects completely disappeared. In conclusion, a safe, short-lasting and repeatable determination of the coronary flow reserve (for instance during PTCA) proved to be possible after intracoronary papaverine injection in low dosages (5 mg).
authors.affiliation: Klinik für Innere Medizin, Humboldt-Universität zu Berlin und Klinikum Berlin-Buch.
authors.forename: N
authors.initials: N
authors.lastname: Franz
authors.forename: D
authors.initials: D
authors.lastname: Modersohn
authors.forename: P
authors.initials: P
authors.lastname: Romaniuk
authors.forename: G
authors.initials: G
authors.lastname: Linss
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D006328:Cardiac Catheterization; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D010208:Papaverine; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D010208:Papaverine
vernacular_title: Bestimmung der Koronarreserve durch intrakoronare Papaverinapplikation: Auswirkungen unterschiedlicher Dosen auf Koronarfluss and Hämodynamik.