title: Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.
abstract: The effect of d- and l-enantiomers of propranolol on desipramine-induced anti-immobility effects and on brain desipramine levels was studied in the rat. Intraperitoneal propranolol and desipramine were administered three times, 25, 6, 2 and 24, 5, 1 h respectively, before the test. It was found that l-propranolol but not d-propranolol, at the same doses (2.5 and 5 mg/kg), antagonized 20 mg/kg desipramine without altering desipramine brain levels. It is suggested that blockade of beta-adrenergic receptors rather than membrane-stabilizing or pharmacokinetic effects is responsible for the antagonism of propranolol toward desipramine.
authors.affiliation: Menarini Ricerche Sud, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mancinelli
authors.forename: V
authors.initials: V
authors.lastname: D'Aranno
authors.forename: M A
authors.initials: MA
authors.lastname: Stasi
authors.forename: A
authors.initials: A
authors.lastname: Lecci
authors.forename: F
authors.initials: F
authors.lastname: Borsini
authors.forename: A
authors.initials: A
authors.lastname: Meli
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism / Q000494:pharmacology*; D007099:Imipramine / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013550:Swimming
chemical_list: C036691:didesipramine; D011433:Propranolol; D007099:Imipramine; D003891:Desipramine