Druckery slope controlled by mitotic rate of enzymatically-altered foci.
Data on hepatocellular foci and tumors for four hepatocarcinogens are analyzed within the framework of a two-mutation model of oncogenesis to determine the biological factor(s) that control the values of N in Druckery's formula DTN = K, where T is the time to 50% tumor incidence at a daily dose D. The two-mutation oncogenic model was found to adequately reproduce the empirical data for all four hepatocarcinogens. The controlling factor of the Druckery slope N was found to be the mitotic rate (MRI) of hepatocellular foci, where MRI = CD1/N, C is a chemical-dependent constant, D is dose, and N is the Druckery slope.
Travis
C C
CC
Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831-6109.
Birkner
P D
PD
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D015994:Incidence; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D008938:Mitosis / Q000187:drug effects; D008954:Models, Biological; D009154:Mutation; D051381:Rats; D013997:Time Factors
D002273:Carcinogens