title: The periapical tissue reactions to a calcium phosphate cement in the teeth of monkeys.
abstract: A calcium phosphate cement, Grossman sealer, and Sargenti N2 were compared under conditions where root canals of monkey incisors were deliberately overfilled and the apical tissue responses were evaluated histologically. The periapical tissues exposed to Sargenti N2 revealed severe irritation at all times through the 6-month experimental period. The reactions to Grossman sealer were milder but persisted throughout the observation period. The calcium-phosphate-cement treated animals showed mild tissue irritation after 1 month, but thereafter the adverse tissue reactions were minimal. New bone formation adjacent to the cement was also observed. These results point to the possibility that calcium phosphate cement might be used in simplified endodontic procedures. The compatibility of calcium phosphate cement with the periapical tissue suggests that the cement may have other applications in dentistry and medicine.
authors.affiliation: School of Dentistry, College of Medicine, National Taiwan University, Taipei.
authors.forename: Y C
authors.initials: YC
authors.lastname: Hong
authors.forename: J T
authors.initials: JT
authors.lastname: Wang
authors.forename: C Y
authors.initials: CY
authors.lastname: Hong
authors.forename: W E
authors.initials: WE
authors.lastname: Brown
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000633:toxicity*; D003738:Dental Cements / Q000633:toxicity*; D007509:Irritants; D008251:Macaca; D010483:Periapical Diseases / Q000139:chemically induced* / Q000473:pathology; D010486:Periapical Tissue / Q000473:pathology; D012387:Root Canal Filling Materials / Q000633:toxicity*
chemical_list: D002130:Calcium Phosphates; D003738:Dental Cements; D007509:Irritants; D012387:Root Canal Filling Materials; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous