Sister-chromatid exchanges (SCE) induced by p-dichlorobenzene in cultured human lymphocytes.
We have investigated the ability of p-dichlorobenzene (p-DCB) to induce sister-chromatid exchanges (SCE) in cultured human lymphocytes. From our results we can conclude that p-DCB was able to induce a cytotoxic effect, measured as a decrease in third and second metaphases, together with an increase of SCEs.
Carbonell
E
E
Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Puig
M
M
Xamena
N
N
Creus
A
A
Marcos
R
R
D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002722:Chlorobenzenes / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002722:Chlorobenzenes; D009153:Mutagens; C018511:4-dichlorobenzene