Liquid chromatographic determination of the enantiomers of ibuprofen in plasma using a chiral AGP column.
A reversed-phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen. The enantiomers and the internal standard 4-pentylphenylacetic acid are extracted from plasma, separated and quantified on a Chiral-AGP column using ultraviolet detection. The simplicity, sensitivity and precision of the method makes it convenient for use in pharmacokinetic studies.
Pettersson
K J
KJ
Department of Bioanalysis, Astra Research Centre AB, Södertälje, Sweden.
Olsson
A
A
D000818:Animals; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007052:Ibuprofen / Q000097:blood*; D011817:Rabbits
D007052:Ibuprofen