title: [Tactical and technical errors in surgical treatment of patients with generalized myasthenia gravis].
abstract: From experience in surgical treatment of 1,800 patients with generalized myasthenia as well as from literature data, the authors analyse the main tactical and technical errors in the treatment of this category of patients. A complex approach and a program of improving the results of treatment of patients with myasthenia were elaborated. Compulsory examination of the mediastinum for revealing possible affection of the thymus is indicated in myasthenia. Median sternotomy with ++extra-fascial removal of the whole thymus is considered the optimal approach in thymectomy. Thymomthymectomy with extensive removal of the areolar tissue of the anterior mediastinum is believed to be the operation of ++choice in tumors of the thymus. Thymus tissue which is not removed during the operation is one of the causes of recurrent myasthenia, while unjustified extension of the volume of the operation in nonneoplastic affection of the thymus is also inadvisable. Preoperative radiotherapy is not recommended. The principles elaborated in the clinic enabled the authors to reduce the frequency of assisted ventilation sevenfold and the incidence of infectious complications, pneumonia among others, to 0.6%.
authors.forename: O S
authors.initials: OS
authors.lastname: Shkrob
authors.forename: P S
authors.initials: PS
authors.lastname: Vetshev
authors.forename: A L
authors.initials: AL
authors.lastname: Sokolov
authors.forename: D I
authors.initials: DI
authors.lastname: Shagal
authors.forename: I Kh
authors.initials: IKh
authors.lastname: Ippolitov
authors.forename: L I
authors.initials: LI
authors.lastname: Voronov
authors.forename: Z Sh
authors.initials: ZSh
authors.lastname: Khodzhaev
mesh_terms: D000328:Adult; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*; D011239:Prednisolone / Q000008:administration & dosage; D011300:Preoperative Care; D012008:Recurrence; D012720:Severity of Illness Index; D013934:Thymectomy / Q000009:adverse effects / Q000379:methods*
chemical_list: D002800:Cholinesterase Inhibitors; D011239:Prednisolone
vernacular_title: Takticheskie i tekhnicheskie oshibki pri khirurgicheskom lechenii bol'nykh generalizovannoĭ miastenii.