title: Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis.
abstract: We have reported a case of phenytoin-induced hemocytophagic histiocytosis indistinguishable on clinical and histopathologic grounds from malignant histiocytosis. We emphasize the need to investigate for microbiologic causes and drug ingestion, even if the diagnosis of malignant histiocytosis is plausible. We think that reactive and malignant histiocytosis are not really two distinct entities with different etiologies, but a continuum of host responses to several insults with different degrees of aggressiveness depending on the host immune status.
authors.affiliation: Department of Internal Medicine, Huelva General Hospital, Spain.
authors.forename: V M
authors.initials: VM
authors.lastname: Gutiérrez-Ravé Pecero
authors.forename: R
authors.initials: R
authors.lastname: Luque Márquez
authors.forename: M A
authors.initials: MA
authors.lastname: Ayerza Lerchundi
authors.forename: A
authors.initials: A
authors.lastname: Fernández Jurado
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D054747:Histiocytic Sarcoma / Q000097:blood / Q000175:diagnosis*; D015614:Histiocytosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D010672:Phenytoin