title: Nutrient balance in humans: effects of diet composition.
abstract: The purpose of this study was to examine the effect of alterations in diet composition on energy expenditure and nutrient balance in humans. Eight adults (three men, five women) ate a high-carbohydrate (60% of calories from carbohydrate) and a high-fat (60% of calories from fat) diet for 7 d each according to a randomized, crossover design. Six subjects were studied for an additional week on a mixed diet (45% of calories from fat). For each subject, total caloric intake was identical on all diets and was intended to provide the subject's maintenance energy requirements. All subjects spent days 3 and 7 of each week in a whole-room indirect calorimeter. Diet composition did not affect total daily energy expenditure but did affect daily nutrient oxidation by rapidly shifting substrate oxidation to more closely reflect the composition of the diet. These results show that diet composition can affect substrate oxidation without producing measurable effects on total energy expenditure.
authors.affiliation: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232.
authors.forename: J O
authors.initials: JO
authors.lastname: Hill
authors.forename: J C
authors.initials: JC
authors.lastname: Peters
authors.forename: G W
authors.initials: GW
authors.lastname: Reed
authors.forename: D G
authors.initials: DG
authors.lastname: Schlundt
authors.forename: T
authors.initials: T
authors.lastname: Sharp
authors.forename: H L
authors.initials: HL
authors.lastname: Greene
mesh_terms: D000328:Adult; D001823:Body Composition; D001833:Body Temperature Regulation; D001835:Body Weight; D002151:Calorimetry; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D010084:Oxidation-Reduction; D011897:Random Allocation
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats