[Resistance of 700 gram-negative bacterial strains to antiseptics and antibiotics].
The sensitivity of 701 Gram negative strains, representing 16 species or bacterial genera, towards 4 antiseptics (cetrimide, chlorhexidine, hexachlorophene, mercuric chloride) and 6 antibiotics (ampicillin, streptomycin, erythromycin, chloramphenicol, kanamycin, tetracycline) was analysed. For 3 antiseptics (cetrimide, chlorhexidine, mercuric chloride) minimal inhibitory concentration distribution showed strains to be heterogeneous, particularly in the group Pseudomonas. Most strains were resistant to antibiotics. The statistical analysis of correlation showed positive resistance links between antiseptics (cetrimide, chlorhexidine, hexachlorophene) or between these antiseptics and antibiotics for S marcescens and Alcaligenes. Many strains proved resistant, at the same time, to mercuric chloride and to several antibiotics. These associations of resistance suggest either a common mechanism of action or a crossed resistance.
Maris
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Centre national d'études vétérinaires et alimentaires, laboratoire des médicaments vétérinaires, Fougères, France.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013223:Statistics as Topic
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local
Résistance aux antiseptiques et aux antibiotiques de 700 souches bactériennes à gram négatif.