Binary effects of carcinogens and tumor promoters--a preliminary chemical structural analysis of BCIDB and PCIDB.
Identification of potential interactions in exposures, either to simultaneous or sequential combinations of carcinogenic chemicals and mixtures of carcinogen and carcinogenesis-modifying chemical agents, pose formidable difficulties in human health risk assessments. Studies over the past four decades have revealed synergistic interactions among various classes of carcinogenic chemicals. An earlier effort to identify a possible chemical structural basis of interaction of binary combinations of carcinogens led to the development of Binary Carcinogen Interaction Data Base (BCIDB). A recent endeavor to identify a structural basis of interactions of carcinogens and carcinogenesis modifying chemical agents resulted in Promoter-Carcinogen Interaction Data Base (PCIDB). An attempt will be made in this report to briefly discuss chemical class-class interaction and initiator-target organ orientation as recorded in BCIDB and PCIDB.
Rao
V R
VR
Science Applications International Corporation, McLean, Virginia.
D000818:Animals; D002273:Carcinogens / Q000145:classification / Q000633:toxicity*; D003043:Cocarcinogenesis; D016206:Databases, Bibliographic; D004357:Drug Synergism; D013329:Structure-Activity Relationship
D002273:Carcinogens