Prevention of post-herpetic neuralgia. Evaluation of treatment with oral prednisone, oral acyclovir, and radiotherapy.
The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiotherapy was of no value in either the acute or post-herpetic phase.
Benoldi
D
D
Department of Dermatology, University of Parma, Italy.
Mirizzi
S
S
Zucchi
A
A
Allegra
F
F
D000208:Acute Disease; D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006562:Herpes Zoster / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000517:prevention & control* / Q000532:radiotherapy; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*
D011241:Prednisone; D000212:Acyclovir