Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
Wilson
K
K
Department of Psychogeriatrics, Mossley Hill Hospital, Liverpool.
Bowen
D
D
Francis
P
P
Tyrrell
P
P
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000187:drug effects; D006801:Humans; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D010091:Oximes; D010830:Physostigmine / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D010830:Physostigmine