title: Ketamine enantiomers and acetylcholinesterase.
abstract: (-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
authors.affiliation: National Defence Research Establishment, Division of Experimental Medicine, Umeå, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Puu
authors.forename: M
authors.initials: M
authors.lastname: Koch
authors.forename: E
authors.initials: E
authors.lastname: Artursson
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D001665:Binding Sites; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D006868:Hydrolysis; D007649:Ketamine / Q000494:pharmacology*; D007700:Kinetics; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010766:Phosphorylation; D013237:Stereoisomerism
chemical_list: D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D007649:Ketamine; D000110:Acetylcholinesterase