CSF baclofen levels after intrathecal administration in severe spasticity.
The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
Sallerin-Caute
B
B
Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Toxicologie Fondamentales du CNRS, Toulouse, France.
Lazorthes
Y
Y
Monsarrat
B
B
Cros
J
J
Bastide
R
R
D000328:Adult; D001418:Baclofen / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy / Q000378:metabolism*
D001418:Baclofen