title: [Analysis of the clinical effect of Adelavin infusion during enflurane anesthesia on post-operative hepatic function].
abstract: The protective effect of Adelavin, which is made of liver essence, for maintaining postoperative hepatic function was analysed in 85 patients who had enflurane anesthesia. The patients who showed hepatic dysfunction preoperatively were excluded from this trial. Adelavin was infused at a speed of 0.1 mg.kg-1.hr-1 during anesthesia. The group who had upper abdominal surgery in the Adelavin group showed significantly lower incidence of postoperative hepatic dysfunction. The group who had only enflurane anesthesia in the Adelavin group showed significantly lower incidence of postoperative hepatic dysfunction. These results suggest that the Adelavin infusion has a significant protective effect on hepatic function after enflurane anesthesia.
authors.affiliation: Department of Anesthesiology, School of Medicine, Hokkaido University, Sapporo.
authors.forename: Y
authors.initials: Y
authors.lastname: Hanaoka
authors.forename: S
authors.initials: S
authors.lastname: Kaseno
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: O
authors.initials: O
authors.lastname: Kemmotsu
mesh_terms: D000769:Anesthesia, Inhalation; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004737:Enflurane / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008110:Liver Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014020:Tissue Extracts / Q000032:analysis*
chemical_list: D008110:Liver Extracts; D014020:Tissue Extracts; D004737:Enflurane