title: The repair of DNA damages induced in normal human skin fibroblasts exposed to simulated sunlight.
abstract: The induction and repair of DNA damages produced by exposure of normal human skin fibroblasts to the simulated sunlight produced by a solar simulator were examined. The photoproducts measured were pyrimidine dimers, E. coli endonuclease III-sensitive sites, 6-4 photoproducts, Dewar isomers, DNA-protein crosslinks, and DNA single-strand breaks. The results of these experiments serve to form a basis for the quantitation of damages induced by exposure to sunlight.
authors.affiliation: Department of Radiation Medicine, Brown University, Providence, Rhode Island 02912.
authors.forename: B S
authors.initials: BS
authors.lastname: Rosenstein
authors.forename: D L
authors.initials: DL
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000032:analysis; D043224:Deoxyribonuclease (Pyrimidine Dimer); D004706:Endodeoxyribonucleases; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects*; D006801:Humans; D011740:Pyrimidine Dimers / Q000378:metabolism; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D011740:Pyrimidine Dimers; D004706:Endodeoxyribonucleases; D043224:Deoxyribonuclease (Pyrimidine Dimer)