Hypolipidemic effect of metrifonate and the relationship to serum cholinesterase inhibition.
The organophosphate metrifonate has been demonstrated to produce a hypolipidemic effect in the Syrian golden hamster as demonstrated by turbidimetric analysis of lipoprotein precipitation by heparin. A sex-related difference in sensitivity to the hypolipidemia may exist, although metrifonate appears to be an effective serum cholinesterase inhibitor in both sexes. Therefore, metrifonate may be a useful probe in the investigation of organophosphate-induced hypolipidemia.
Udom
C E
CE
Neurosciences Program, Indiana University, Bloomington 47405.
Smith
T J
TJ
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002802:Cholinesterases / Q000097:blood; D006224:Cricetinae; D005260:Female; D006995:Hypobetalipoproteinemias / Q000139:chemically induced*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D012737:Sex Factors; D014236:Trichlorfon / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D000960:Hypolipidemic Agents; D014236:Trichlorfon; D002802:Cholinesterases