[Bone marrow transplantation in congenital defects of immunity].
BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.
Porta
F
F
Clinica Pediatrica, Ospedale Civile, Brescia, Italia.
Notarangelo
L D
LD
Candotti
F
F
Mazzolari
E
E
Lanfranchi
A
A
Ugazio
A G
AG
D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005060:Europe; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000401:mortality / Q000628:therapy*
D006680:HLA Antigens
Il trapianto di midollo osseo nei difetti congeniti dell'immunità.