Isoprenyl phosphinylformates: new inhibitors of squalene synthetase.
Biller
S A
SA
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543.
Forster
C
C
Gordon
E M
EM
Harrity
T
T
Rich
L C
LC
Marretta
J
J
Ciosek
C P
CP
D000818:Animals; D000924:Anticholesteremic Agents; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D009943:Organophosphorus Compounds; D013729:Terpenes; D013186:Farnesyl-Diphosphate Farnesyltransferase