The absence of resistance in congenitally athymic nude mice toward infection with the intestinal nematode, Trichuris muris: resistance restored by lymphoid cell transfer.
Congenitally athymic (nude) mice maintained infections of Trichuris muris for at least 40 days post-infection, whereas phenotypically normal mice expelled the worms by 18 days post-infection. Complete worm expulsion occurred in nude mice which had been given spleen cells. On the other hand, a partial resistance to the infection was observed in nude mice which received thymus or mesenteric lymph node cells. No significant worm reduction was seen by injection of immune serum.
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Department of Parasitology, Kitasato University School of Medicine, Sagamihara, Japan.
D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D016219:Immunotherapy, Adoptive; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D013154:Spleen / Q000276:immunology; D014257:Trichuriasis / Q000276:immunology* / Q000628:therapy; D014258:Trichuris / Q000276:immunology*