title: Effect of intraperitoneal administration of heparin to patients on continuous ambulatory peritoneal dialysis (CAPD).
abstract: The effect of intraperitoneal administration of heparin to patients on continuous ambulatory peritoneal dialysis (CAPD) remains obscure. We examined 8 patients on CAPD to investigate its effect. When 2.5 U/ml or 5 U/ml of heparin was given intraperitoneally, t1/2 of heparin activity in the dialysate was 0.5 to 2 hrs, and 6 hrs after administration its activity was 0.5 U/ml and 1.4 U/ml respectively. Whole blood clotting time was hardly affected because the transfer of heparin to the plasma was minimal. The plasma antithrombin III (AT-III) levels were comparable to patients on hemodialysis, but the AT-III level in the dialysate was only 1.5% of those in the plasma. We conclude that the intraperitoneal administration of heparin at these doses is effective in preventing fibrin precipitation when intraperitoneal AT-III levels are expected to be relatively increased such as at the start of CAPD or in the presence of peritonitis.
authors.affiliation: 2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Kuno
authors.forename: Y
authors.initials: Y
authors.lastname: Nagura
authors.forename: M
authors.initials: M
authors.lastname: Hatano
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D006493:Heparin / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D006493:Heparin