Immediate effects of intravenous clomipramine on sleep and sleep-related secretion in depressed patients.
An i.v. challenge dose of clomipramine (12.5 mg) was given to eight outpatients with major depression. The procedure facilitated the examination of all-night sleep and sleep-related neuroendocrine changes (cortisol, growth hormone, and prolactin). In comparison to baseline saline nights, the patients experienced a profound suppression of rapid eye movement (REM) sleep throughout the night with no rebound recovery in the second half of the night. Furthermore, REM-suppressing effects were noted on the following no-drug night. In contrast, little effect on delta wave sleep was found, except for increased consolidation of delta waves within stage 3 and 4 sleep. Delta sleep measures were significantly correlated with levels of cortisol and growth hormone.
Kupfer
D J
DJ
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213-2593.
Pollock
B G
BG
Perel
J M
JM
Jarrett
D B
DB
McEachran
A B
AB
Miewald
J M
JM
D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D002997:Clomipramine / Q000008:administration & dosage*; D003700:Delta Rhythm; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology
D011388:Prolactin; D013006:Growth Hormone; D002997:Clomipramine; D006854:Hydrocortisone