title: Signet-ring cell lymphoma. Report of a case diagnosed by fine needle aspiration cytology.
abstract: A case of signet-ring cell lymphoma initially diagnosed by fine needle aspiration (FNA) cytology is described. Immediate evaluation of air-dried smears showed a mixture of large and small lymphoid cells, including some signet-ring forms. Immunocytochemical studies of Cytospin preparations of the remaining aspirate yielded a diagnosis of a large-cell-type B-cell signet-ring lymphoma. Subsequent bone marrow biopsies confirmed the diagnosis of a low-grade lymphoma. The advantages of on-site evaluation in aspiration cytology are discussed.
authors.affiliation: Department of Pathology, University of Pennsylvania Medical School, Philadelphia.
authors.forename: J M
authors.initials: JM
authors.lastname: Limjoco
authors.forename: J J
authors.initials: JJ
authors.lastname: Brooks
authors.forename: J B
authors.initials: JB
authors.lastname: Alavi
mesh_terms: D015415:Biomarkers; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008214:Lymphocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D015415:Biomarkers