A comparison of the hypoalgesic effect of paracetamol in slow-release and plain tablets on laser-induced pain.
1. In a double-blind, three way, cross-over study 15 volunteers received plain paracetamol tablets 1000 mg every 6th hour, paracetamol slow-release tablets 2000 mg every 12th hour, and placebo. Steady state conditions were established over a 5 day period preceding each test session. 2. Plain paracetamol was given twice in the 12h test session, initially and after 6 h, and the slow-release formulation was given once at the start of the session. 3. Hypoalgesia, measured by experimentally laser-induced pain (pain threshold), and plasma concentrations of paracetamol were measured hourly for 12 h. 4. Both formulations of paracetamol were significantly superior (P = 0.0003) to placebo, but not difference in analgesic efficacy was found between the two regimens.
Nielsen
J C
JC
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Bjerring
P
P
Arendt-Nielsen
L
L
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D000700:Analgesics; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D012684:Sensory Thresholds / Q000187:drug effects; D013607:Tablets
D000700:Analgesics; D003692:Delayed-Action Preparations; D013607:Tablets; D000082:Acetaminophen