title: [Various mechanisms of disorders of the regulation of hemostasis in acute hemorrhage].
abstract: A review has been presented of the author's own investigations and the literature data on the mechanisms of hemocoagulation disorders in acute hemorrhage. The main attention is paid to the state of the vascular-thrombocytic component of the hemostasis system. In acute hemorrhage, like in the normal state, the blood hemostatic potential is characterized by the combination of parameters of the labile and stable components of the hemostasis system. Under conditions of acute hemorrhage the shifts in the blood coagulation system are directed towards hypercoagulation, and the syndrome of disseminated intravascular blood coagulation may develop. Parameters of the vascular-thrombocytic component of the hemostasis play the main role in the triggering of blood coagulation mechanisms. Accelerated movement of fluid from tissues to the blood flow, disorders in microcirculation and blood rheology, monocytic phagocytes system blocking, toxigenic and hemolytic properties of the plasma play a role in the activation of the vascular-thrombocytic hemostasis.
authors.forename: N A
authors.initials: NA
authors.lastname: Gorbunova
mesh_terms: D000208:Acute Disease; D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001815:Bloodletting; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006470:Hemorrhage / Q000097:blood* / Q000150:complications; D006801:Humans; D010974:Platelet Aggregation / Q000502:physiology; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000209:etiology; D013997:Time Factors
vernacular_title: Nekororye mekhanizmy narusheniia reguliatsii gemostaza pri ostroĭ krovopotere.