title: Elevation of plasma concentrations of haloperidol after the addition of fluoxetine.
abstract: Fluoxetine (20 mg/day) was added for 7-10 days to stable doses of haloperidol given to eight psychotic patients. Mean plasma concentrations of haloperidol were elevated by 20% (p less than 0.05), but extrapyramidal side effects did not increase appreciably, indicating a relatively minor interaction between these agents.
authors.affiliation: Erich Lindemann Mental Health Center, Boston, Mass.
authors.forename: D C
authors.initials: DC
authors.lastname: Goff
authors.forename: K K
authors.initials: KK
authors.lastname: Midha
authors.forename: A W
authors.initials: AW
authors.lastname: Brotman
authors.forename: M
authors.initials: M
authors.lastname: Waites
authors.forename: R J
authors.initials: RJ
authors.lastname: Baldessarini
mesh_terms: D000328:Adult; D000368:Aged; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D006220:Haloperidol / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013268:Stimulation, Chemical
chemical_list: D005473:Fluoxetine; D006220:Haloperidol