Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia.
The effects of soy protein (35% of protein energy) given as a beverage and those of cow-milk proteins were investigated on plasma lipoprotein concentrations in children with familial hypercholesterolemia (FH). Subjects were randomly assigned to either the soy-protein or cow-milk-protein experimental period, with subsequent crossover after a washout period, each period lasting 4 wk. Diets were planned to provide 20% energy as protein, 28% as fat (polyunsaturated:monounsaturated:saturated fatty acids, 1:3:3) and less than 200 mg cholesterol/d. No changes were observed in either plasma cholesterol, low-density-lipoprotein cholesterol, or apolipoprotein concentrations. However, the soy beverage significantly reduced the concentrations of triglyceride and very-low-density-lipoprotein cholesterol (P less than 0.05) and significantly increased the concentrations of high-density-lipoprotein cholesterol (HDL-C) and HDL3-C (P less than 0.04 and P less than 0.03, respectively). These results indicate that the administration of soy protein may induce clinically beneficial effects in children with FH.
Laurin
D
D
Département de nutrition humaine et de consommation, Université Laval, Québec, Canada.
Jacques
H
H
Moorjani
S
S
Steinke
F H
FH
Gagné
C
C
Brun
D
D
Lupien
P J
PJ
D001053:Apolipoproteins / Q000097:blood; D001628:Beverages; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D002149:Energy Intake; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D014674:Plant Proteins, Dietary / Q000008:administration & dosage / Q000627:therapeutic use*; D030262:Soybean Proteins; D013025:Glycine max; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004044:Dietary Proteins; D008055:Lipids; D008074:Lipoproteins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014280:Triglycerides