title: Thrombocytosis in adults: analysis of 777 patients.
abstract: A total of 777 patients with thrombocytosis, defined as a platelet count of greater than 500 x 10(9)l-1, seen in a University hospital over a 1-year period, were studied prospectively for aetiology. The most frequent causes of thrombocytosis were infection (21.9%), rebound thrombocytosis (19.4%), tissue damage (17.9%), chronic inflammatory disorders (13.1%) and malignancy (5.9%). Thrombocytosis associated with multiple causative factors, occurring simultaneously, was seen in 6.1% of cases. Thrombocytosis of greater than or equal to 1 million x 10(9)l-1 was found most frequently in patients with multiple aetiological factors occurring at the same time, in myeloproliferative disorders, or in postsplenectomy patients.
authors.affiliation: Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
authors.forename: C R
authors.initials: CR
authors.lastname: Santhosh-Kumar
authors.forename: M D
authors.initials: MD
authors.lastname: Yohannan
authors.forename: K E
authors.initials: KE
authors.lastname: Higgy
authors.forename: S A
authors.initials: SA
authors.lastname: al-Mashhadani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010976:Platelet Count; D011446:Prospective Studies; D012008:Recurrence; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D013922:Thrombocytosis / Q000097:blood / Q000209:etiology*