Increased production of growth factors and epidermal growth factor receptor by gastric carcinoma.
Four growth factors and one growth factor receptor have been studied in carcinomas from 22 gastrectomy specimens and compared to non-malignant tissue from the same specimen. cDNA probes for transforming growth factors alpha and beta, platelet-derived growth factor A and B, insulin-like growth factor II and epidermal growth factor receptor were used to assay messenger RNA transcripts for the growth factors by dot hybridization. Increased levels of all the transcripts were found in carcinomas compared to benign tissue (P less than 0.05). No correlation was found between any of the growth factors studied and tumour stage or patient survival. Increased growth factor production by gastric cancers may be important in the pathogenesis of these tumours and further work is required to establish their role.
Paterson
I M
IM
Department of Surgery, St. George's Hospital, London, UK.
Bennett
C A
CA
Corbishley
C M
CM
Luqmani
Y
Y
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D015342:DNA Probes; D066246:ErbB Receptors / Q000096:biosynthesis*; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D015342:DNA Probes; D006133:Growth Substances; D012333:RNA, Messenger; D066246:ErbB Receptors