Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.
2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were identified for the first time as novel endogenous amines in parkinsonian and normal human brains by gas chromatography-mass spectrometry. It is of interest that these tetrahydroisoquinolines are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which produces Parkinson's disease.
Niwa
T
T
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Takeda
N
N
Yoshizumi
H
H
Tatematsu
A
A
Yoshida
M
M
Dostert
P
P
Naoi
M
M
Nagatsu
T
T
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives* / Q000032:analysis; D000368:Aged; D000369:Aged, 80 and over; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007546:Isoquinolines / Q000032:analysis*; D008297:Male; D010300:Parkinson Disease; D044005:Tetrahydroisoquinolines
D001679:Biogenic Amines; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C069194:2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; C069193:1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine