[Prevention of atopic hypersensitivity. Principles and status of current knowledge. A review for the obstetrician].
Genetic disposition, exposure to allergens and additional factors that favour the manifestation, are the relevant conditions for IgE-mediated atopic allergies. Among a group of markers of atopy, only family history and cord-blood-IgE are of practical relevance as predictors of the disease. No parameter identifies all children at risk, but cord-blood-IgE seems the best in predicting severe diseases. Recent studies demonstrate possibilities and limitations of programs in atopy prevention. The effects are antigen-specific and limited to the time of elimination. Some food allergies form exceptions to this rule, because their manifestation is limited to a vulnerable period and can thus be prevented completely by elimination. The present state of knowledge shows hydrolysed milk preparations to be useful for the prevention of cow's milk allergies.
Rebmann
H
H
Abt. Kinderheilkunde II mit Poliklinik, Universitäts-Kinderklinik, Tübingen.
D000485:Allergens / Q000009:adverse effects*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D012307:Risk Factors
D000485:Allergens; D007073:Immunoglobulin E
Atopieprophylaxe. Grundlagen und Kenntnisstand. Eine Ubersicht für den Geburtshelfer.