The putative sigma factor KatF has a central role in development of starvation-mediated general resistance in Escherichia coli.
KatF is required for the expression of some 32 carbon starvation proteins in Escherichia coli including 6 previously identified as Pex. Mutants with the katF gene survive carbon and nitrogen starvation poorly. Many of the KatF-regulated starvation proteins are common to those induced by other stresses, and the mutant failed to develop starvation-mediated cross protection to osmotic, oxidative, and heat stresses. Furthermore, thermal resistance was not induced in the mutant by heat preadaptation, and it exhibited an altered pattern of protein synthesis at elevated temperature. Thus, KatF is a major switch that controls the starvation-mediated resistant state in E. coli.
McCann
M P
MP
Department of Microbiology and Immunology, Stanford University, California 94305-5402.
Kidwell
J P
JP
Matin
A
A
D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D002244:Carbon; D003470:Culture Media; D015180:Electrophoresis, Gel, Two-Dimensional; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D015870:Gene Expression; D005798:Genes, Bacterial; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009154:Mutation; D009997:Osmotic Pressure; D012808:Sigma Factor / Q000235:genetics*
D001426:Bacterial Proteins; D003470:Culture Media; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D002244:Carbon; D006861:Hydrogen Peroxide