Correlation between molecular and clinical events in the evolution of chronic myelocytic leukemia to blast crisis.
A patient with typical Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML) was studied during sequential phases of disease: (1) initial chronic phase; (2) myeloid blast crisis; (3) second chronic phase; and (4) accelerated disease. A point mutation in the coding sequence of the p53 gene first appeared concomitantly with the blast crisis and then disappeared with the re-establishment of a second chronic phase. The chromosomal concomitant of the molecular alteration was a deletion of 17p. These observations suggest that abnormalities of the p53 anti-oncogene are temporally related to the clinical progression of some cases of CML and are probably responsible for the development of blast crisis in these cases.
Foti
A
A
UCLA School of Medicine 90024-1678.
Ahuja
H G
HG
Allen
S L
SL
Koduru
P
P
Schuster
M W
MW
Schulman
P
P
Bar-Eli
M
M
Cline
M J
MJ
D000328:Adult; D001483:Base Sequence; D001752:Blast Crisis / Q000235:genetics*; D002872:Chromosome Deletion; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005091:Exons; D015321:Gene Rearrangement; D006801:Humans; D007438:Introns; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53; D004247:DNA