title: Demonstration of a phospholipase A2 inhibitor in human plasma and in plasma from the European hedgehog (Erinaceus europaeus).
abstract: 1. Endogenous phospholipase A2 (PLA2) inhibitors in human plasma and in plasma from the hedgehog (Erinaceus europaeus) were demonstrated. 2. The PLA2 activity increased 45-fold in human plasma when a PLA2 binding factor was removed. Furthermore, two peaks of PLA2 inhibitory activity were found after DEAE-chromatography. 3. High levels of PLA2 inhibitory activity was found in plasma from the European hedgehog, E. europaeus. 4. The molecular weight was estimated to 140,000. 5. On DEAE-chromatography two peaks were found which were chromatographically similar to the PLA2 inhibitors in human plasma.
authors.affiliation: Department of Occupational Medicine, Linköping University, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Lindahl
authors.forename: C
authors.initials: C
authors.lastname: de Wit
authors.forename: B
authors.initials: B
authors.lastname: Weström
authors.forename: H
authors.initials: H
authors.lastname: von Schenck
authors.forename: C
authors.initials: C
authors.lastname: Tagesson
mesh_terms: D000328:Adult; D000818:Animals; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D006364:Hedgehogs / Q000097:blood*; D006801:Humans; D008970:Molecular Weight; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2