Differential effects of chronic nicotine administration on dopaminergic receptor binding sites in rat nigrostriatal and mesolimbic regions.
1. The effects of chronic (14 day) administration of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic dopaminergic receptor binding sites were determined. 2. Chronic administration of nicotine preferentially increased the number of dopaminergic receptor binding sites in the striatal, but not the mesolimbic area of rat brain.
Fung
Y K
YK
University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln 68583-0740.
Lau
Y S
YS
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*
D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D009538:Nicotine