title: Efficacy of oral administration of ofloxacin in lower respiratory tract infections in aged patients with chronic lung disease.
abstract: The efficacy of ofloxacin for the treatment of lower respiratory tract infection was evaluated in aged patients with chronic lung disease. Results are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and in helper/suppressor T cell ratio; superoxide production by peripheral blood white cells was decreased after treatment; interleukin-2 production was rather increased. We concluded that improvement in the immunological parameters indicated the efficacy of ofloxacin for lower respiratory tract infection in aged patients with chronic lung disease.
authors.affiliation: Yokufukai Geriatric Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: M
authors.initials: M
authors.lastname: Yokouchi
authors.forename: N
authors.initials: N
authors.lastname: Teramoto
authors.forename: T
authors.initials: T
authors.lastname: Nagase
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: E
authors.initials: E
authors.lastname: Ohtomo
authors.forename: H
authors.initials: H
authors.lastname: Orimo
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy*; D001991:Bronchitis / Q000188:drug therapy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D015242:Ofloxacin