Interferon alpha treatment of accelerated-phase chronic myeloid leukemia in relapse after bone marrow transplantation: a case with complete cytogenetic and molecular remission.
We describe here a patient with Philadelphia-positive chronic myeloid leukemia who had a hematologic and cytogenetic relapse after bone marrow transplantation. A diagnosis of accelerated phase was made when an additional malignant clone was detected. This clone was probably derived from the primitive Philadelphia clone, with duplication and rearrangement of the Philadelphia chromosome. The patient was treated with interferon alpha 2a and experienced a complete cytogenetic and molecular remission, with full reconstitution of the donor marrow.
Steegmann
J L
JL
Servicio de Hematologia, Hospital de la Princesa, Madrid, Spain.
Pérez
M
M
Vázquez
L
L
Perez
G
G
López
J
J
Lamana
M
M
Ferro
M T
MT
Resino
M
M
González-Sarmiento
R
R
Sánchez
I
I
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D015465:Leukemia, Myeloid, Accelerated Phase / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged
D007370:Interferon Type I