title: Double-blind controlled study of botulinum toxin in adductor spasmodic dysphonia.
abstract: The treatment of adductor spasmodic dysphonia using botulinum toxin A was conducted in 13 patients as a double-blind, placebo-controlled study. Patients were diagnosed independently by an interdisciplinary team consisting of speech pathologists, an otolaryngologist, and a neurologist. The toxin or saline was injected into each thyroarytenoid muscle under electromyographic and laryngoscopic guidance. Botulinum toxin A markedly reduced perturbation, decreased fundamental frequency range, and improved the spectrographic characteristics of the voice. Fundamental frequency and phonation time remained unchanged. Patients injected with botulinum toxin A noticed significant improvement in their voices in comparison with the placebo-treated group. Excessive breathiness of the voice occurred in two patients, and mild bleeding in one patient in the botulinum toxin A-treated group. Injection with saline resulted in edema of the vocal cord in one patient. Botulinum toxin A proved to be an effective and safe treatment of adductor spasmodic dysphonia.
authors.affiliation: Department of Neurology, University of California, Irvine Medical Center, Orange 92668.
authors.forename: D D
authors.initials: DD
authors.lastname: Troung
authors.forename: M
authors.initials: M
authors.lastname: Rontal
authors.forename: M
authors.initials: M
authors.lastname: Rolnick
authors.forename: A E
authors.initials: AE
authors.lastname: Aronson
authors.forename: K
authors.initials: K
authors.lastname: Mistura
mesh_terms: D001905:Botulinum Toxins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D007273:Injections, Intramuscular; D007821:Laryngeal Muscles; D013018:Sound Spectrography; D013035:Spasm / Q000188:drug therapy; D013060:Speech / Q000502:physiology; D014832:Voice Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
chemical_list: D001905:Botulinum Toxins