Halothane enhances the binding of diazepam to synaptic membranes from rat cerebral cortex.
The effects of halothane on diazepam binding to the rat cerebral synaptic membranes were investigated. Halothane at the concentrations of 0.63, 1.3 and 4.1 mmol/l increased the binding by 12, 23 and 33%, respectively, compared to the control in the absence of halothane. The increments were dependent on the presence of Cl-. The findings indicate that halothane and diazepam have an interaction at receptor level.
Nakao
S
S
Department of Anesthesia, Kyoto University Hospital, Japan.
Arai
T
T
Murakawa
M
M
Mori
K
K
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D006221:Halothane / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013570:Synaptic Membranes / Q000378:metabolism*
D003975:Diazepam; D006221:Halothane