t(16;21)(p11.2;q22): a recurrent primary rearrangement in ANLL.
We have identified three patients with acute nonlymphocytic leukemia (ANLL), subtypes M2, M4, and M7, who had a t(16;21)(p11.2;q22) in the affected cells. There are six previously reported cases of ANLL with the same t(16;21). The t(6;21) should therefore be included as another primary rearrangement in ANLL. Follow-up of these cases, though still limited, suggests a poor prognosis, as most patients have achieved a clinical remission but only for a short duration.
Morgan
R
R
Cancer Center of Southwest Biomedical Research Institute and Genetrix, Inc., Scottsdale, Arizona 85251.
Riske
C B
CB
Meloni
A
A
Ries
C A
CA
Johnson
C H
CH
Lemons
R S
RS
Sandberg
A A
AA
D000328:Adult; D002675:Child, Preschool; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic