title: Nonmetastatic thoracic neuroblastomas: a review of 40 cases.
abstract: From 1982 to 1987, 40 children with non-metastatic thoracic neuroblastoma were treated with the same therapeutic regimen. According to TNM staging, there were 11 CS I, 19 CS II, and 10 CS III. All patients underwent surgery; 30 had primary surgical excision; in 10 whose tumors were deemed unresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscopic residual disease or regional lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach, EFS is 92% with a median follow-up of 40 months. Severe complications were rare and sequellae appear to be related to the disease, i.e., neurologic consequences of cord compression.
authors.affiliation: Pediatric Hematology and Oncology Unit, Hôpital de Purpan, Toulouse, France.
authors.forename: H
authors.initials: H
authors.lastname: Rubie
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: A
authors.initials: A
authors.lastname: Giron
authors.forename: G
authors.initials: G
authors.lastname: Lemoine
authors.forename: M
authors.initials: M
authors.lastname: Gruner
authors.forename: L
authors.initials: L
authors.lastname: Brugieres
authors.forename: D
authors.initials: D
authors.lastname: Valteau-Couanet
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: J
authors.initials: J
authors.lastname: Lemerle
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011879:Radiotherapy Dosage; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide