A corticosteroid receptor in neuronal membranes.
Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.
Orchinik
M
M
Department of Zoology, Oregon State University, Corvallis 97331.
Murray
T F
TF
Moore
F L
FL
D000663:Amphibians; D000818:Animals; D001345:Autoradiography; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002458:Cell Fractionation; D002462:Cell Membrane; D003345:Corticosterone / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009474:Neurons / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013574:Synaptosomes / Q000378:metabolism; D014316:Tritium
D011965:Receptors, Glucocorticoid; D014316:Tritium; D003345:Corticosterone