Translocation 1;7 in hematologic disorders--a report of three further cases. Absence of amplification of the gene for the epidermal growth factor receptor.
We report three new cases with a hematologic disorder and the unbalanced translocation der(1)t(1;7)(p11;p11). It has been speculated that the gene for the epidermal growth factor receptor, localized to the short arm of chromosome 7, might be amplified in cases with this translocation. We have demonstrated that there is no amplification of this gene in these three cases.
Abrahamson
G M
GM
Leukaemia Research Fund Molecular and Cytogenetic Haematology Unit, John Radcliffe Hospital, Headington, Oxford, U.K.
Rack
K
K
Buckle
V J
VJ
Oscier
D G
DG
Kelly
S
S
Wainscoat
J S
JS
D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D006402:Hematologic Diseases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics; D011087:Polycythemia Vera / Q000235:genetics; D055728:Primary Myelofibrosis / Q000235:genetics; D014178:Translocation, Genetic
D066246:ErbB Receptors