title: Pathogenesis of retinal dystrophy in the Royal College of Surgeons rat.
abstract: The Royal College of Surgeons (RCS) rat is an animal with genetically transmitted progressive retinal dystrophy. We compared histopathologically the RCS rat retina with normal age-matched control retinas (Long-Evans rats) using light and scanning electron microscopy. Retinal degeneration begins with alteration of the rod outer segments. There is a progressive involvement of the entire retina, with all layers affected by 45 days. The three-dimensional view obtained with scanning electron microscopy provides another perspective on the pathogenetic changes of the RCS retina.
authors.affiliation: Department of Ophthalmology, Ohio State University, Columbus 43210.
authors.forename: F H
authors.initials: FH
authors.lastname: Davidorf
authors.forename: D B
authors.initials: DB
authors.lastname: Mendlovic
authors.forename: D W
authors.initials: DW
authors.lastname: Bowyer
authors.forename: P M
authors.initials: PM
authors.lastname: Gresak
authors.forename: B C
authors.initials: BC
authors.lastname: Foreman
authors.forename: K T
authors.initials: KT
authors.lastname: Werling
authors.forename: R B
authors.initials: RB
authors.lastname: Chambers
mesh_terms: D000818:Animals; D008855:Microscopy, Electron, Scanning; D010786:Photoreceptor Cells / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012162:Retinal Degeneration / Q000209:etiology* / Q000473:pathology; D012374:Rod Cell Outer Segment / Q000648:ultrastructure