Boerhaavia diffusa: a study of its hepatoprotective activity.
An alcoholic extract of whole plant Boerhaavia diffusa given orally exhibited hepatoprotective activity against experimentally induced carbon tetrachloride hepatotoxicity in rats and mice. The extract also produced an increase in normal bile flow in rats suggesting a strong choleretic activity. The extract does not show any signs of toxicity up to an oral dose of 2 g/kg in mice.
Chandan
B K
BK
Department of Pharmacology, Council of Scientific and Industrial Research, Jammu Tawi, India.
Sharma
A K
AK
Anand
K K
KK
D000818:Animals; D001646:Bile / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D007194:India; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D011517:Prothrombin Time; D051381:Rats; D013448:Sulfobromophthalein
D010936:Plant Extracts; D013448:Sulfobromophthalein