title: Inhibition of pyrogen Escherichia coli fever with intracerebral administration of prazosin, dihydrobenzperidol and nifedipin in the rabbits.
abstract: 1. The thermoregulatory, effector processes were investigated after treatment with prazosin (PRA), dihydrobenzperidol (DHBP) and nifedipin (ADA) applied to the thermosensitive zone of the anterior hypothalamus (PO/AH) on normothermic and feverish rabbits (LPS, lipopolysaccharide E. coli; 1 meg/kg, i.v.). 2. The alpha 1-noradrenergic receptor antagonists, PRA and DHBP, applied to the PO/AH produced an abolishment of fever elicited by pyrogen i.v. injection mainly because of vasodilation of ear skin vessels and attenuation of metabolic rate. 3. Calcium channel blocker, ADA, also induced a decline in the rabbit's core temperature in the same manner. 4. All these drugs given to the PO/AH did not change the body temperature in normothermic rabbits. 5. These results, therefore, strongly suggest that alpha 1-noradrenergic receptors subserve the coordinated thermoregulatory mechanisms in PO/AH which are required for antipyresis. The inhibition of Ca2+ turnover is discussed as a possible mechanism of antipyretic action of these drugs given to the PO/AH.
authors.affiliation: Department of Pharmacology, Medical Academy, Gdańsk, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Szreder
authors.forename: Z
authors.initials: Z
authors.lastname: Korolkiewicz
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004329:Droperidol / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D007032:Hypothalamus, Anterior / Q000033:anatomy & histology; D007267:Injections; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011224:Prazosin / Q000008:administration & dosage / Q000494:pharmacology*; D011301:Preoptic Area / Q000033:anatomy & histology; D011749:Pyrogens / Q000037:antagonists & inhibitors*; D011817:Rabbits
chemical_list: D011749:Pyrogens; D009543:Nifedipine; D004329:Droperidol; D011224:Prazosin