Equine H7N7 influenza A viruses are highly pathogenic in mice without adaptation: potential use as an animal model.
Equine H7N7 influenza A viruses, representing a broad range of isolates, were lethal in mice without adaptation. After repeated passages, A/Equine/London/1416/73 acquired neurotropism upon intranasal infection. Thus, mice infected with equine influenza A viruses provide a model system for the study of highly virulent mammalian influenza viruses.
Kawaoka
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Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
D000818:Animals; D004195:Disease Models, Animal; D006389:Hemagglutinins, Viral / Q000378:metabolism; D053126:Influenza A Virus, H7N7 Subtype; D009980:Influenza A virus / Q000145:classification / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009422:Nervous System Diseases / Q000382:microbiology; D012703:Serotyping; D013045:Species Specificity; D014357:Trypsin / Q000494:pharmacology; D014779:Virus Replication
D006389:Hemagglutinins, Viral; D014357:Trypsin