Release of (14C)5-hydroxytryptamine from human platelets by red wine.
Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susceptible individuals, release of 5-HT, possibly from central stores, could represent a plausible mechanism for its mode of action.
Jarman
J
J
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK.
Glover
V
V
Sandler
M
M
D001515:Beer; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000097:blood*; D014920:Wine / Q000009:adverse effects*
D012701:Serotonin; D012110:Reserpine