Some electrochemical characteristics of synthetic analogs of nucleic acid components. III. Derivatives of 5-fluorouridine. An attempt to find correlation between some of their characteristics.
The polarographic reduction and parameter tg alpha of a series of synthetic 5-fluorouracil derivatives (various 5'-modified nucleosides) were studied. The studied compounds were compared with analogous nucleosides of the uridine series. It was confirmed that the value of tg alpha which may suggest a potential carcinogenic activity of the compound studied, is dependent upon the reducibility of the compound and is associated with the cleavability of the nucleoside bond, i.e. with the ability to liberate fluorouracil. It was found that Ftorafur, an antitumor agent widely used in clinical practice, displayed a very high value of tg alpha. In the group of polyaromates such high tg alpha values had been found in compounds which are known to have carcinogenic activity.
Novotný
L
L
Cancer Research Institute, Slovak Academy of Science, Bratislava, Czechoslovakia.
Vachálková
A
A
D000818:Animals; D007939:Leukemia L1210; D009696:Nucleic Acids / Q000138:chemical synthesis*; D011048:Polarography; D005641:Tegafur / Q000737:chemistry / Q000494:pharmacology; D008063:Thioctic Acid; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014500:Uracil Nucleotides / Q000737:chemistry; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D009696:Nucleic Acids; D014500:Uracil Nucleotides; D005641:Tegafur; C001943:5-fluorouridine; D008063:Thioctic Acid; D014529:Uridine