[Effect of ischemia and postischemic reperfusion on some mechanisms of regulation, rhythmogenesis, and contractile function of the heart in rats].
Isolated rat hearts were perfused with Krebs' solution after Langendorff's method. Decrease of the perfusion rate from 8.8 to 2.2 ml/min for 40 minutes led to inhibition of the contractile and rhythmic function of the heart and its reactivity to isoproterenol (IP) and acetyl choline (AC), drop in the intensity of lipid peroxidation appraised according to malonyl dialdehyde (MDA) level, and reduction of noradrenaline (NA) concentration in the myocardium in maintenance of the cAMP level. Forty-minute postischemic reperfusion normalized cardiac function, caused further diminution of the heart reactive properties to IP and AC, activated lipid peroxidation, reduced the NA concentration, and maintained a normal MDA level. The effect of ischemia and reperfusion on the regulatory mechanisms, rhythmogenesis, and contractile function of the heart is discussed.
Burtsev
S P
SP
Ivanov
A I
AI
Ivanova
T I
TI
Koloskov
Iu B
IuB
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D015425:Myocardial Reperfusion; D051381:Rats
Vliianie ishemii i postishemicheskoĭ reperfuzii na nekotorye mekhanizy reguliatsii, ritmogenez i sokratitel'nuiu funktsiiu serdtsa u krys.