title: [Sensitivity and specificity of a simplified, standardized 13C-urea breath test for the demonstration of Helicobacter pylori].
abstract: A simplified 13C-urea breath test (UBT) for detection of Helicobacter pylori (Hp) infection was evaluated in 50 patients. Following upper gastrointestinal endoscopy the patients received 100 ml of a liquid test meal with 100 mg 13C-urea. Breath samples were obtained at baseline and 30 minutes respectively. The UBT was positive (difference of 13CO2 enrichment exceeding 5%) in 33/35 patients with culture-proven Hp infection and negative in 14/15 patients in whom microbiological culture, histology and a urease test (CLO-test) were negative. We conclude that in view of its high sensitivity (94%) and specificity (93%) the UBT is useful for rapid, non-invasive diagnosis of Hp infection.
authors.affiliation: Abteilung für Gastroenterologie, Kantonsspital Basel.
authors.forename: D J
authors.initials: DJ
authors.lastname: Good
authors.forename: S
authors.initials: S
authors.lastname: Dill
authors.forename: S
authors.initials: S
authors.lastname: Mossi
authors.forename: R
authors.initials: R
authors.lastname: Frey
authors.forename: C
authors.initials: C
authors.lastname: Beglinger
authors.forename: G A
authors.initials: GA
authors.lastname: Stalder
authors.forename: B
authors.initials: B
authors.lastname: Meyer-Wyss
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D002247:Carbon Isotopes; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014508:Urea
chemical_list: D002247:Carbon Isotopes; D014508:Urea
vernacular_title: Sensitivität und Spezifität eines vereinfachten, standardisierten 13C-Urea-Atemtests zum Nachweis von Helicobacter pylori.