Effect of ampicillin and sulbactam/ampicillin on the immune system.
An investigation was carried out into the possible effects of ampicillin and a sulbactam/ampicillin combination on the immune system of healthy subjects. The following immunological variables were compared before and after antibiotic therapy: proliferation response of peripheral mononuclear cells to phytohaemagglutinin; variation of T- and B-lymphocytes; dosage of interleukin-2; and production of immunoglobulin A. The data obtained did not demonstrate any immunodepressive activity by either ampicillin or the sulbactam/ampicillin combination.
Gismondo
M R
MR
Department of Microbiology, Faculty of Medicine, University of Catania, Italy.
Chisari
G
G
Lo Bue
A M
AM
D000293:Adolescent; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007070:Immunoglobulin A / Q000096:biosynthesis; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013407:Sulbactam / Q000008:administration & dosage*
D007070:Immunoglobulin A; D007376:Interleukin-2; C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam