Correlation of data from the strain A mouse bioassay with long-term bioassays.
Fifty-nine chemicals that had completed National Cancer Institute rat and mouse 2-year carcinogenicity tests were tested in the strain A mouse pulmonary tumor assay. Without knowledge of chemical identity, 53 chemicals were tested in strain A mice in one laboratory and 30 were tested in a second independent laboratory. Strain A tests on 24 of these chemicals were conducted in both laboratories. The strain A results were generally not predictive of the 2-year rat and mouse carcinogenicity test results. Furthermore, there was poor agreement of strain A results between the two laboratories. Although a variety of explanations may be invoked to explain the lack of concordance between the strain A tests and the 2-year rat and mouse tests, no one factor is sufficient to rationalize the poor concordance between strain A and 2-year carcinogenicity bioassay results.
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National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
D000818:Animals; D001681:Biological Assay; D015197:Carcinogenicity Tests / Q000379:methods*; D051379:Mice; D008805:Mice, Inbred A; D013997:Time Factors