Phytogrowth-inhibitory and antimicrobial activities of 3,4'-dihydroxy-alpha,beta-diethylstilbene, the isomer of diethylstilbestrol.
3,4'-Dihydroxy-alpha,beta-diethylstilbene (I), like diethylstilbestrol (II), showed phytogrowth-inhibitory and antimicrobial activities. First, compound I showed strong growth-inhibitory activity against the roots of two kinds of plants. The inhibitory activity of I was almost equal to that of sodium 2,4-dichlorophenoxyacetate used as a positive control. The phytogrowth-inhibitory activity of I was much higher than that of II. Next, unlike II, I had broad antifungal spectrum against phathogenic fungi. Compound I showed antifungal activity against six kinds of Fusarium oxysporum sp. This compound also had antibacterial activity against pathogenic and plant-pathogenic bacteria. These antibacterial activities of I were as high as those of II, the isomer of I. It should be emphasized that by shifting one of the phenolic hydroxyl groups of II to meta-position, phytogrowth-inhibitory activity was largely increased, while antimicrobial activity was unchanged.
Inamori
Y
Y
Osaka University of Pharmaceutical Sciences, Japan.
Ogawa
M
M
Nishiguchi
K
K
Koyama
S
S
Tsujibo
H
H
Miki
Y
Y
Takemura
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D010937:Plant Growth Regulators; C069314:3,4'-dihydroxy-alpha,beta-diethylstilbene; D004054:Diethylstilbestrol