title: Steroid-responsive tubular aggregate myopathy.
abstract: We report a man with an acute myalgia/cramp syndrome and tubular aggregates on his muscle biopsy. He was placed on prednisone and was found to be exquisitely sensitive to the drug, with changes of only 5 mg precipitating recurrence of symptoms. He was eventually tapered off all steroids, without symptoms, and repeat biopsy showed no tubular aggregates. We recommend similar patients be given a trial of high-dose steroids.
authors.affiliation: Department of Neurology, Rhode Island Hospital, Providence.
authors.forename: J M
authors.initials: JM
authors.lastname: Gilchrist
authors.forename: M
authors.initials: M
authors.lastname: Ambler
authors.forename: P
authors.initials: P
authors.lastname: Agatiello
mesh_terms: D001706:Biopsy; D006801:Humans; D008297:Male; D008870:Microtubules / Q000648:ultrastructure*; D008875:Middle Aged; D009120:Muscle Cramp / Q000188:drug therapy* / Q000473:pathology; D009132:Muscles / Q000648:ultrastructure*; D010146:Pain / Q000503:physiopathology; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure; D013577:Syndrome
chemical_list: D011241:Prednisone