title: Effects of cytarabine on glucoregulation in suckling rats.
abstract: The effects of cytarabine (beta-cytosine arabinoside) on glucose metabolism is not well known. The present study showed that 5 mg/kg of cytarabine decreased plasma glucose level in 10 day old rat 4 hours after ip injection. Hepatic glycogenolysis decreased 4 hours after cytarabine injection. Thus, cytarabine alters newborn glucoregulation.
authors.affiliation: Department of Pediatrics, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153.
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: W P
authors.initials: WP
authors.lastname: Zeller
authors.forename: R M
authors.initials: RM
authors.lastname: Hurley
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001786:Blood Glucose / Q000378:metabolism*; D003561:Cytarabine / Q000494:pharmacology*; D008112:Liver Glycogen / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D008112:Liver Glycogen; D003561:Cytarabine