Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats.
3,9- and 3,7-Dinitrofluoranthene (3,9- and 3,7-DNF), 3-nitrofluoranthene (3-NF) and benzo[a]pyrene (B[a]P) were tested for pulmonary carcinogenicity by intrapulmonary implantation of the compounds into rat lung. These chemicals were given in various doses as suspensions in beeswax-trycaprylin and the animals were observed for 100 weeks. The control group received no drugs. The incidences of lung tumors were 19/21 (90.5%), 7/10 (70%) and 1/10 (10%) in rats treated with 200, 100 and 50 micrograms of 3,9-DNF, 4/9 (44.4%), 3/10 (30%) and 0/10 (0%) in rats treated with 200, 100 and 50 micrograms of B[a]P, 12/22 (54.5%) in rats treated with 200 micrograms of 3,7-DNF and 1/20 (5%) in rats treated with 1000 micrograms of 3-NF respectively. No lung tumors were found in control rats. The incidence of lung tumors induced by 3,9-DNF was twice as high as that induced by B[a]P, when the equivalent dose levels of the two compounds were compared. Histologically, most of the tumors induced by 3,9- and 3,7-DNF and B[a]P were squamous cell carcinomas.
Horikawa
K
K
Department of Health Science, Fukuoka Environmental Research Center, Japan.
Sera
N
N
Otofuji
T
T
Murakami
K
K
Tokiwa
H
H
Iwagawa
M
M
Izumi
K
K
Otsuka
H
H
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D008297:Male; D009153:Mutagens; D051381:Rats; D011916:Rats, Inbred F344; D015996:Survival Rate
D002273:Carcinogens; D005449:Fluorenes; D009153:Mutagens; C052116:3,7-dinitrofluoranthene; D001564:Benzo(a)pyrene; C062117:3,9-dinitrofluoranthene; C033643:3-nitrofluoranthene