[Induction chemotherapy with cisplatin and 5-FU in locally advanced head and neck cancer. Study of 2 administration schedules].
67 patients were included in two different protocols with cisplatin and 5-fluorouracil as induction chemotherapy. Group A (30 patients), received cisplatin in bolus and 5-FU in continuous infusion for 120 hours, and Group B (37 patients), were treated with cisplatin and 5-FU both in continuous infusion for 96 hours. All patients received surgery and/or radiotherapy after chemotherapy. Overall response in Group A was 73% with 27% Complete Clinic Response (CCR), and in Group B 81% with 40.5% (CCR). Overall survival at 24 months was 58% and 63%, respectively.
Muñoz
A
A
Servicio de Otorrinolaringología, Hospital Clínico Universitario de Salamanca.
Cruz
J J
JJ
Pardal
J L
JL
Sánchez
A
A
Fonseca
E
E
Bernal
A G
AG
Nieto
A
A
Cañizo
A
A
D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral
D002945:Cisplatin; D005472:Fluorouracil
Quimioterapia de inducción con cisplatino y 5-FU en cáncer de cabeza y cuello localmente avanzado. Estudio en dos protocolos de administración.