title: 2H-pyrano[2,3-f]quinazoline derivatives with platelet antiaggregating and other activities.
abstract: The synthesis of some N,N-disubstituted 4-amino-5,6-dihydro-3,8-diphenyl-2H-pyrano[2,3-f]quinazolin- 2-ones by the reaction of phenylchloroketene with a series of N,N-disubstituted (E)-6-aminomethylene-7,8-dihydro-2-phenylquinazolin-5(6H)-ones, followed by dehydrochlorination of the primary adducts with DBN, is described. The methylbenzylamino and diphenylamino derivatives showed platelet antiaggregating activity in vitro superior to that of acetylsalicylic acid. The 1-pyrrolidinyl derivative showed appreciable local anesthetic activity in mice, whereas the whole series of compounds exhibited weak antiinflammatory activity in rats.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Longobardi
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: A
authors.initials: A
authors.lastname: Bargagna
authors.forename: P
authors.initials: P
authors.lastname: Schenone
authors.forename: S
authors.initials: S
authors.lastname: Budetta
authors.forename: C
authors.initials: C
authors.lastname: Losasso
authors.forename: M L
authors.initials: ML
authors.lastname: Cenicola
authors.forename: D
authors.initials: D
authors.lastname: Donnoli
authors.forename: D
authors.initials: D
authors.lastname: De Santis
authors.forename: E
authors.initials: E
authors.lastname: Marmo
mesh_terms: D000779:Anesthetics, Local / Q000138:chemical synthesis; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors; D011714:Pyrans; D011799:Quinazolines; D002351:Carrageenan