Models for evaluating compounds for activity against Pneumocystis carinii.
Cultures and animal models have been developed to provide reproducible and uniform systems for evaluation of compounds for effects on Pneumocystis carinii. The culture model allows rapid low-cost screening of drugs for activity against trophozoite forms. The animal models allow testing of efficacy for prophylaxis and therapy of Pneumocystis carinii pneumonia.
Bartlett
M S
MS
Department of Pathology, Indiana University School of Medicine, Indianapolis 46202-5250.
D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D008168:Lung / Q000382:microbiology; D011010:Pneumocystis / Q000187:drug effects* / Q000254:growth & development; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains