Protection against gastric ulcer by verapamil.
The effect of verapamil, a calcium channel blocker, was studied against stress (cold restraint), aspirin and pylorus ligation induced gastric ulcers in rats. Verapamil inhibited ulcerogenic response and ulcer index in all the three types of ulcers. Verapamil also decreased total and free gastric acidity without changing gastric secretory volume.
Srivastava
S K
SK
Department of Pharmacology, (C.D.R.I.), King George's Medical College, Lucknow, India.
Nath
C
C
Gupta
M B
MB
Vrat
S
S
Sinha
J N
JN
Dhawan
K N
KN
Gupta
G P
GP
D000818:Animals; D001241:Aspirin; D003080:Cold Temperature; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D014700:Verapamil / Q000627:therapeutic use*
D014700:Verapamil; D001241:Aspirin