Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa.
Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5-12 mg/kg x 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.
Shukla
B
B
ICMR Centre for Advanced Pharmacological Research on Selected Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Visen
P K
PK
Patnaik
G K
GK
Dhawan
B N
BN
D000082:Acetaminophen; D000818:Animals; D002756:Cholagogues and Choleretics; D002779:Cholestasis / Q000188:drug therapy; D002934:Cinnamates / Q000494:pharmacology*; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D015394:Molecular Structure; D051381:Rats; D012838:Silymarin / Q000494:pharmacology; D014641:Vanillic Acid / Q000494:pharmacology*
D002756:Cholagogues and Choleretics; D002934:Cinnamates; D006027:Glycosides; D012838:Silymarin; C057463:kutkin; D000082:Acetaminophen; D014641:Vanillic Acid