Selenium status in relation to reduced glutathione peroxidase activity in aspirin-sensitive asthma.
Selenium status and its relationship to lowered platelet glutathione peroxidase activity was investigated in 18 subjects with aspirin (ASA)-induced asthma and in asthmatic and non-asthmatic ASA-tolerant subjects. Mean serum selenium concentration in ASA-tolerant asthmatics (1.25 microns/l; 98.5 micrograms/l) was significantly higher than that in ASA-induced asthma subjects (1.14 microns/l; 89.7 micrograms/l) and than that in healthy controls (1.15 microns/l; 91 micrograms/l). Although there was a correlation between serum selenium concentration and platelet glutathione peroxidase activity, enzyme activity was significantly lower in the ASA-induced asthma group compared to other groups even after correcting for selenium status. These results indicate that lowered platelet glutathione peroxidase activity in ASA-induced asthma is a product of both selenium availability and an unidentified syndrome-specific (possibly genetic) factor.
Pearson
D J
DJ
Department of Medicine, University of Manchester, U.K.
Suarez-Mendez
V J
VJ
Day
J P
JP
Miller
P F
PF
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000097:blood* / Q000201:enzymology / Q000209:etiology; D001792:Blood Platelets / Q000201:enzymology; D004342:Drug Hypersensitivity / Q000097:blood / Q000150:complications / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000172:deficiency*; D006801:Humans; D008297:Male; D012643:Selenium / Q000097:blood*
D005979:Glutathione Peroxidase; D012643:Selenium; D001241:Aspirin