beta-Hydroxybutyrate: a urinary marker of imipenem induced nephrotoxicity in the cynomolgus monkey detected by high field 1H NMR spectroscopy.
The use of 1H NMR as a complement to conventional clinical chemistry and histopathology resulted in the detection of hitherto unsuspected changes in urine composition as a result of imipenem induced nephrotoxicity. Large quantities of beta-hydroxybutyrate, as well as other ketone bodies were detected, indicating a disruption of energy metabolism. beta-Hydroxybutyrate may provide a useful non-invasive marker for imipenem toxicity.
Harrison
M P
MP
ICI Pharmaceuticals, Macclesfield, Cheshire, U.K.
Jones
D V
DV
Pickford
R J
RJ
Wilson
I D
ID
D020155:3-Hydroxybutyric Acid; D000818:Animals; D015415:Biomarkers; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006885:Hydroxybutyrates / Q000652:urine*; D015378:Imipenem / Q000008:administration & dosage / Q000633:toxicity*; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008252:Macaca fascicularis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009336:Necrosis; D011188:Potassium / Q000378:metabolism
D015415:Biomarkers; D006885:Hydroxybutyrates; D015378:Imipenem; D003404:Creatinine; D011188:Potassium; D020155:3-Hydroxybutyric Acid