Are syntax errors due to the amino acid sequence of neuroleukin involved in the pathogenesis of the acquired immunodeficiency syndrome (AIDS) and insulin dependent diabetes mellitus (IDDM)?
The main principles of this hypothesis are very general: (i) signal-detection from background noise is one central issue in electronics; (ii) an important source of misunderstanding at different levels of communication is the fact that a given signal may have different meanings in different contexts; (iii) the unique role of chance in developmental biology is generally appreciated (37). In AIDS the basic defect would be the human specific inability to distinguish between the amino acid sequence of neuroleukin and peptides derived from the gp120 envelope protein of HIV, resulting in a slowly progressing failure of the CD4+ T cell-mediated immunity. In IDDM the postulated HLA class II-dependent hypersensitivity to immunological noise could predispose to random contacts between cells with a different signalling language. In the ensuing dialogue neuroleukin secreted by T cells would imply a continuous demand for insulin secretion to pancreatic beta cells resulting in diabetes. This hypothesis does not contradict with the provocative ideas proposed by Duesberg concerning the relationships between HIV and AIDS (24) and the known data on the genesis of IDDM.
Elomaa
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E
Haaga Neurological Rehabilitation Centre, Helsinki, Finland.
Telakivi
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T
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D000595:Amino Acid Sequence; D015704:CD4 Antigens / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000503:physiopathology*; D005956:Glucose-6-Phosphate Isomerase / Q000235:genetics* / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015704:CD4 Antigens; D000949:Histocompatibility Antigens Class II; D005956:Glucose-6-Phosphate Isomerase