[The hemodynamics of oral nicardipine determined by radioisotope ventriculography in patients with ischemic cardiopathy].
Hemodynamic effects of nicardipine (60 mg) were evaluated in 20 patients whose left ventricular ejection fraction was less than 55%. Nicardipine significantly reduced the mean arterial blood pressure by 28 mmHg (p less than 0.0005). Left ventricular ejection fraction and maximal rate of ventricular diastolic filling were increased in 12% and 84.0 VDF/s (p less than 0.0005) respectively. The end diastolic volume was reduced by 26 ml (p less than 0.001). The decrease in mean arterial blood pressure correlates with the increase in the left ventricular ejection fraction (r = 0.76, p less than 0.001) as well as with the reduced end diastolic volume (R = 0.43, p less than 0.05). The results obtained corroborate the beneficial effects of nicardipine on ventricular function of ischemic patients, whose cardiac reserve is reduced.
García-Barreto
D
D
Instituto de Cardiología y Cirugía Cardiovascular, Cuba.
Fránquiz
J
J
Sánchez Catasús
C
C
Llerena Rojas
L
L
Alvarez Ginzo
A
A
Hernández Cañero
A
A
D000284:Administration, Oral; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009529:Nicardipine / Q000008:administration & dosage / Q000494:pharmacology*; D015635:Radionuclide Ventriculography / Q000379:methods; D013318:Stroke Volume / Q000187:drug effects
D009529:Nicardipine
Hemodinámica de la nicardipina oral determinada por ventriculografía radioisotópica en pacientes con cardiopatía isquemica.