[Effect of meals on resorption of bismuth from an oral bismuth gallate/bismuth nitrate preparation].
In a cross-over study in ten healthy volunteers the effect of food on the absorption of bismuth following a single oral dose of 1200 mg (= 12 Bismofalk tablets) was evaluated by measuring its serum levels (0 to 24 h) and urinary excretion (for seven days). If this high dose was ingested one hour prior to the breakfast maximal serum concentrations (16.5 +/- 13.7 micrograms/l; mean +/- SD) were rapidly achieved (tmax = 0.7 +/- 0.5 h). These levels and the low urinary recovery of 0.32 +/- 0.25 mg (corresponding to 0.027% of the dose) indicated a minimal absorption. If the tablets were taken one hour after the breakfast absorption was slightly delayed (tmax = 1.9 +/- 2.4 h), however, the extent appeared to be unchanged. In spite of the high dosage as well as the large interindividual variability in the urinary recovery and the serum concentrations potential "toxic" serum levels of 100 micrograms/l were never reached. Thus, it can be concluded that the bismuth preparation used is suitable for topical action.
Leonhardt
H
H
Krankenhaus Düren, Abteilung für Innere Medizin II, Stuttgart.
Klotz
U
U
D000284:Administration, Oral; D000328:Adult; D000863:Antacids; D000890:Anti-Infective Agents; D001729:Bismuth / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004435:Eating / Q000502:physiology*; D005260:Female; D005707:Gallic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000633:toxicity; D012016:Reference Values
D000863:Antacids; D000890:Anti-Infective Agents; D004338:Drug Combinations; D009942:Organometallic Compounds; D005707:Gallic Acid; C010804:bismuth subnitrate; D001729:Bismuth; C002170:bismuth subgallate
Einfluss von Mahlzeiten auf die Resorption von Wismut aus einem oralen Wismutgallat/Wismutnitrat-Präparat.