The effects of physostigmine infusion on patients with panic disorder.
Nine patients who met both DSM-III and RDC criteria for panic disorder and nine age-matched normal controls received infusions of physostigmine. The patients and normal controls did not differ in either their self-reported or the observer-reported ratings of anxiety, mood, or activation. The two subject groups also did not differ in blood pressure, pulse, or cortisol responses to physostigmine. Physostigmine did not provoke panic attacks in either the control or patients groups.
Rapaport
M H
MH
Department of Psychiatry, University of California, San Diego, School of Medicine and Psychiatry Service, La Jolla 92093.
Risch
S C
SC
Gillin
J C
JC
Golshan
S
S
Janowsky
D
D
D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology* / Q000523:psychology; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects* / Q000502:physiology; D010556:Personality Tests; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology
D011950:Receptors, Cholinergic; C026718:physostigmine salicylate; D010830:Physostigmine; D006854:Hydrocortisone