title: Treatment of coronary heart disease with diet and exercise--problems of compliance.
abstract: The effects of low fat diet and intensive physical exercise were examined in a randomized prospective study in patients with angiographically documented coronary heart disease. In addition to supervised regular physical exercise, patients of the intervention group (n = 18) were subjected to intensive dietary counselling with the aim of a low fat, low cholesterol diet to be maintained for at least 12 months. The control group (n = 27) received relevant advise only and usual care by private physicians. In the intervention group there was significant lowering of plasma triglycerides (202 +/- 82/141 +/- 74 mg/dl) and body weight (78.2 +/- 9.5/73.7 +/- 10.4 kg) while total and LDL cholesterol did not change significantly. There was a tendency for a rise of HDL-cholesterol (35.6 +/- 9.0/40.4 +/- 14.8 mg/dl, p = 0.07). According to 24-hour diet protocols there was a significant lowering of energy intake (2.298 +/- 697/1.602 +/- 758 kcal/day), of fat intake (111.7 +/- 44.4/52.0 +/- 23.9 g/day) and of intake of dietary cholesterol (402.8 +/- 186/161.3 +/- 100.3 mg/day) as well as of saturated fatty acids (42.5 +/- 20.4/14.3 +/- 8.1 g/day). Fatty acid composition of adipose tissue was not correlated with the patients' 24-hour dietary protocols. In the control group there were no changes of plasma lipids, body weight or diet composition according to 24-hour protocols after 1 year compared to data at the beginning of the study. There was, however, a marked correlation of adipose tissue composition and dietary information given by the patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Klinisches Institut für Herzinfarktforschung, Medizinische Universitätsklinik Heidelberg, BRD.
authors.forename: T
authors.initials: T
authors.lastname: Nikolaus
authors.forename: G
authors.initials: G
authors.lastname: Schlierf
authors.forename: G
authors.initials: G
authors.lastname: Vogel
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.forename: I
authors.initials: I
authors.lastname: Wagner
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D001835:Body Weight; D003327:Coronary Disease / Q000178:diet therapy / Q000628:therapy*; D005081:Exercise Therapy; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010349:Patient Compliance
chemical_list: D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins