Successful treatment of adult Henoch-Schönlein purpura with factor XIII concentrate.
We report the cases of three adult patients with severe abdominal complications of Henoch-Schönlein purpura who had low activity of factor XIII during the acute phase of the disease. In all three cases, abdominal symptoms and purpura immediately responded to heat-treated, placenta-derived factor XIII concentrate. No adverse effects were experienced. Factor XIII concentrate replacement should be considered as the initial treatment for severe abdominal symptoms in adult Henoch-Schönlein purpura associated with a decreased level of factor XIII activity.
Utani
A
A
Department of Dermatology, Tenri Hospital, Nara, Japan.
Ohta
M
M
Shinya
A
A
Ohno
S
S
Takakuwa
H
H
Yamamoto
T
T
Suzaki
T
T
Danno
K
K
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005176:Factor XIII / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000473:pathology / Q000628:therapy*; D008297:Male; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy
D005176:Factor XIII