Mechanism of aminoglycoside resistance in Danish Staphylococcus aureus strains during the years 1979-1987.
A total of 49 gentamicin-resistant strains of Staphylococcus aureus isolated from blood (n = 26) or from other sites (n = 23) during the years 1979 to 1987 were evaluated for the presence of aminoglycoside-inactivating enzymes on the basis of minimum inhibitory concentrations measured by agar dilution as well as inhibition zone diameters determined by disc diffusion. Enzymatic activity was caused by AAC (6')III/APH (2") in 45 strains, and by AAC (6')III/APH (2") + APH (3') in four strains. No changes in the distribution of enzymatic activity were observed during the eight years.
Madsen
O R
OR
Department of Clinical Microbiology, Bispebjerg Hospital, Copenhagen, Denmark.
Lorentzen
J S
JS
Frimodt-Møller
N
N
Mortensen
I
I
Rosdahl
V T
VT
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003718:Denmark; D004352:Drug Resistance, Microbial; D013211:Staphylococcus aureus / Q000187:drug effects*; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents