title: [Disorders of fibrinolysis and thrombophilic states, risk factors and possibilities of dietary effects].
abstract: An inadequate efficiency of the fibrinolytic system was revealed in 50-60% of subjects suffering young age from venous thrombosis or myocardial infarction. In a group of 27 patients with the history of deep venous thrombosis of the idiopathic type the authors revealed a significant relationship between the elevated body weight and inadequate fibrinolysis manifested by a reduced fibrinolytic capacity and excess inhibitor of plasminogen activator and its inadequate decline after desmopressin infusion (DDAVP). In a group of 29 patients, who had suffered a myocardial infarction when young, the authors revealed a significant association between reduced fibrinolytic capacity and elevated body weight, hypertriglyceridaemia and increased immunoreactive insulin secretion after a glucose load. In half the investigated subjects it proved possible to improve the reduced fibrinolytic capacity by a low energy diet.
authors.affiliation: I. interní klinika LF UK Plzen.
authors.forename: V
authors.initials: V
authors.lastname: Cepelák
authors.forename: J
authors.initials: J
authors.lastname: Dvorák
authors.forename: L
authors.initials: L
authors.lastname: Vít
authors.forename: H
authors.initials: H
authors.lastname: Cepeláková
authors.forename: V
authors.initials: V
authors.lastname: Beránek
mesh_terms: D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D002149:Energy Intake; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D013924:Thrombophlebitis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control
chemical_list: D003894:Deamino Arginine Vasopressin
vernacular_title: Poruchy fibrinolýzy u trombofilních stavů, jejich rizikové faktory a moznost ovlivnĕní dietou.