[Prognosis of local-regional recurrence in breast carcinoma].
992 primary breast cancers were treated at the Gynaecological Department of the University Hospital of Zürich between 1971 and 1988. Local recurrence (LR) has occurred in 131 patients up to now after a median follow-up of 5.1 years. 75% of the LR manifested the first three years after operation. Especially the locoregional (axillary) recurrences occurred early. The frequency of LR was independent of the menopausal status and the steroid receptors, but was dependent on the initial axillary nodal status and the tumor size. Patients with nodal involvement had recurrences significantly more often (74 of 372 = 20%) than those without (34 of 469 = 7%). LR of patients with tumors smaller than or equal to 2 cm occurred in 7%, in patients with tumors greater than 2 cm in 17%. The 5-year survival of all patients and the patients with a LR was 80% and 57% respectively. The longer the disease-free interval, the better the prognosis of survival. The findings suggest, that especially an early LR can not be looked at as merely a local problem but rather as a signal of a systemic manifestation of the disease.
Wyss
P
P
Universitäts-Frauenklinik, Zürich.
Rageth
J C
JC
Köhler
K
K
Unger
C
C
Hochuli
E
E
D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008593:Menopause; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011379:Prognosis; D011987:Receptors, Steroid
D011987:Receptors, Steroid
Die Prognose des lokoregionären Rezidivs beim Mammakarzinom.