Renal nerve activity does not contribute to the development of renovascular hypertension in rats with abdominal aortic constriction.
This study examines the influence of renal nerves on the development of renovascular hypertension in proximal aortic constricted rats. The rats were studied 1 week after unilateral or bilateral denervation of the renal artery. Denervation had no effect on the increase in mean arterial pressure induced by the constriction. The glomerular filtration rate and filtration fraction in control and in proximal aortic constricted rats were not influenced by the denervation. The Na excretion was increased in the denervated kidney both in control and in proximal aortic constricted rats. Plasma angiotensin II levels were not different from controls in innervated or unilaterally denervated proximal aortic constricted rats. In bilaterally denervated proximal aortic constricted rats the plasma angiotensin II levels were significantly higher. The renovascular hypertension and the alteration in renal function in proximal aortic constricted rats are not dependent on renal nerve activity.
Eklöf
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Department of Pediatrics, St Görans Children's Hospital, Stockholm, Sweden.
Hökflet
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Aperia
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D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001012:Aorta, Abdominal / Q000503:physiopathology*; D001794:Blood Pressure; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D003251:Constriction, Pathologic; D003714:Denervation; D006978:Hypertension, Renovascular / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D009475:Neurons, Afferent / Q000473:pathology; D009478:Neuropeptide Y / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D009478:Neuropeptide Y; D000804:Angiotensin II; D012964:Sodium; D015740:Calcitonin Gene-Related Peptide