title: Analgesic principles from Aralia cordata Thunb.
abstract: The analgesic principles from Aralia cordata Thunb, were identified with (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14),15-dien-19-oic acid (PA), respectively. Both compounds were significantly effective regarding analgesics, hypothermia, duration of pentobarbital-induced anesthesia, and depression of locomotor activity enhanced by methamphetamine at doses of 300 mg/kg (KA) and 500 mg/kg (PA) by oral administration.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Okuyama
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000700:Analgesics; D004224:Diterpenes; C014341:argyrophilic acid; C008911:pimaric acid