Synthesis and biological activities of some pyrrolopyrazoles and 2-pyrazolines.
Cycloaddition reactions of the nitrilimines 4-6 with N-arylmaleimides 7 and acrylamide (11) yield the pyrrolopyrazole derivatives 8-10 and 2-pyrazolines 12, respectively, in excellent yield. The regioselectivity and biological activities of some of the new compounds were investigated.
Ead
H A
HA
Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.
Hassaneen
H M
HM
Abdallah
M A
MA
Mousa
H A
HA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011720:Pyrazoles; D011758:Pyrroles