Regulation by epidermal growth factor of the expression of transforming growth factor-beta 1 mRNA in cultured rat liver epithelial cells.
Expression of transforming growth factor (TGF)-beta 1 mRNA in cultured rat liver epithelial cells is stimulated by epidermal growth factor (EGF), and this increased expression reflects enhanced transcription of the gene. Transient stimulation of TGF-beta expression by EGF/TGF-alpha may function as the mechanism for control of stimulated cell proliferation, such as that typified by liver regeneration.
Tsao
M S
MS
Department of Pathology, Montreal General Hospital, Quebec, Canada.
Zhang
X Y
XY
Liu
C
C
Grisham
J W
JW
D000818:Animals; D015152:Blotting, Northern; D002455:Cell Division / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D015870:Gene Expression; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000235:genetics*
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D003609:Dactinomycin; D004815:Epidermal Growth Factor