title: Changes in Rift Valley fever neutralizing antibody prevalence among small domestic ruminants following the 1987 outbreak in the Senegal River basin.
abstract: Following the Rift Valley fever (RVF) epizootic of 1987 in the Senegal River basin, 2 series of serosurveys were carried out. In 1988 and 1989, respectively, 303 and 331 randomly selected sheep and goats were investigated and sera tested for the presence of specific RVF-virus-neutralizing antibodies. In 1988, 24.4% of the sera was found to have anti-RVF neutralizing antibodies and in 1989, 19.3% was found. In 1988, we observed in the Dagana district, including the 1987 epizootic area, a significantly higher prevalence (71.1%) than in the two other more distant districts of Podor (21.5%) and Matam (9.7%). From 1988 to 1989, the antibody seroprevalence dropped significantly from 71.7 to 23.9% within the Dagana district. Young animals showed a significantly lower antibody prevalence (7.9%, N = 114) than adults (25.3%, N = 217). RVF virus circulated at a low level in 1988-89 without any epizootic manifestation. The population turnover generated an important non-immune population potentially at risk.
authors.affiliation: Institut Sénégalais de Recherches agricoles (ISRA), Dakar-Hann.
authors.forename: Y
authors.initials: Y
authors.lastname: Thiongane
authors.forename: J P
authors.initials: JP
authors.lastname: Gonzalez
authors.forename: A
authors.initials: A
authors.lastname: Fati
authors.forename: J A
authors.initials: JA
authors.lastname: Akakpo
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D006041:Goats; D009500:Neutralization Tests; D011897:Random Allocation; D012295:Rift Valley Fever / Q000453:epidemiology / Q000276:immunology; D012296:Rift Valley fever virus / Q000276:immunology*; D012307:Risk Factors; D012675:Senegal / Q000453:epidemiology; D012756:Sheep
chemical_list: D000914:Antibodies, Viral