Effects of cytarabine on glucoregulation in suckling rats.
The effects of cytarabine (beta-cytosine arabinoside) on glucose metabolism is not well known. The present study showed that 5 mg/kg of cytarabine decreased plasma glucose level in 10 day old rat 4 hours after ip injection. Hepatic glycogenolysis decreased 4 hours after cytarabine injection. Thus, cytarabine alters newborn glucoregulation.
Goto
M
M
Department of Pediatrics, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153.
Zeller
W P
WP
Hurley
R M
RM
D000818:Animals; D000833:Animals, Suckling; D001786:Blood Glucose / Q000378:metabolism*; D003561:Cytarabine / Q000494:pharmacology*; D008112:Liver Glycogen / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D008112:Liver Glycogen; D003561:Cytarabine