[Studies on ouinolone antibiotics. II. Synthesis and antibacterial activity of 7-aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3 -carbo xylic acids and their derivatives].
7-Aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid and their derivatives were synthesized and their antibacterial activities were evaluated. Among them, compounds having an alkyl group at alpha-position of the amino group were found to have in vitro and in vivo antibacterial activity comparable to that of ciprofloxacin. Structure-activity relationship of these compounds was also stated.
Yoshida
T
T
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd., Fukui, Japan.
Yamamoto
Y
Y
Yagi
N
N
Takahasi
Y
Y
Yasuda
S
S
Katoh
H
H
Itoh
Y
Y
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents