A study of occupational exposure to isopropylbiphenyls (Sure Sol-250).
Environmental and medical examinations in workers exposed to the isopropylbiphenyl (IPBs) mixture, Sure Sol-250, in a capacitor-manufacturing plant were carried out once a year for three years. Levels of the total IPBs ranged from 0.03 to 36.6 mg/m3 with a mean of 5.6 mg/m3. The time-weighted average (TWA) exposures varied between 0.3 and 1.8 mg/m3. Physical and laboratory examinations (blood cell count, liver and kidney function tests and also antipyrine metabolism were normal) revealed no adverse effects of IPBs. Based on these observations as well as on the results of our six-month oral toxicity studies in rats, not presented in this paper, we recommend a TWA-MAC (maximum allowable concentration) of 10 mg/m3 for IPBs.
Krampl
V
V
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
Suchánek
P
P
Doupovcová
M
M
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D001713:Biphenyl Compounds / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D016022:Case-Control Studies; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D016273:Occupational Exposure; D012463:Saliva / Q000737:chemistry
D000395:Air Pollutants, Occupational; D001713:Biphenyl Compounds; C069469:Sure-Sol 250; D000118:Acetylglucosaminidase