Forskolin preferentially dilates the afferent arteriole in the canine kidney.
Intrarenal infusion of forskolin (0.2 microgram/kg/min) in anesthetized dogs increased renal blood flow (RBF) and glomerular filtration rate (GFR) to the same degree but did not change the mean arterial pressure or heart rate. Forskolin also increased urine flow and urinary sodium excretion. The proportional increases in RBF and GFR may result from a preferential action of forskolin to dilate the afferent arteriole.
Tamaki
T
T
Department of Pharmacology, Kagawa Medical School, Japan.
Hasui
K
K
Shoji
T
T
Aki
Y
Y
Kiyomoto
H
H
Iwao
H
H
Abe
Y
Y
D000262:Adenylyl Cyclases / Q000187:drug effects; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005576:Colforsin; D000262:Adenylyl Cyclases