title: Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group.
abstract: The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis. Patients were seropositive for Toxoplasma gondii antibodies and had clinical signs compatible with toxoplasmic encephalitis. Data was available on 33 patients, 15 of whom received pyrimethamine p.o./clindamycin i.v. and then p.o., and 18 of whom received pyrimethamine p.o./sulfadiazine p.o. The interim evaluation did not reveal a remarkable difference between the two regimens in the clinical or radiologic response. Adverse reactions to both regimens were common and frequently multiple, there being more adverse gastrointestinal reactions in patients on pyrimethamine/clindamycin and more adverse hematological reactions in those on pyrimethamine/sulfadiazine.
authors.affiliation: Stanford University School of Medicine, Department of Medicine, CA 94305.
authors.forename: B R
authors.initials: BR
authors.lastname: Dannemann
authors.forename: J A
authors.initials: JA
authors.lastname: McCutchan
authors.forename: D M
authors.initials: DM
authors.lastname: Israelski
authors.forename: D
authors.initials: D
authors.lastname: Antoniskis
authors.forename: C
authors.initials: C
authors.lastname: Leport
authors.forename: B J
authors.initials: BJ
authors.lastname: Luft
authors.forename: J
authors.initials: J
authors.lastname: Chiu
authors.forename: J L
authors.initials: JL
authors.lastname: Vildé
authors.forename: J N
authors.initials: JN
authors.lastname: Nussbaum
authors.forename: M
authors.initials: M
authors.lastname: Orellana
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology
chemical_list: D013411:Sulfadiazine; D002981:Clindamycin; D011739:Pyrimethamine