Late-stage mediators of the inflammatory response: identification of interleukin-1 and a casein-degrading enzyme in equine acute inflammatory exudates.
Interleukin-1 and a casein-degrading enzyme have been identified in an experimental system for studying acute inflammation in the horse. The levels of both the cytokine and the proteinase increased over the first 24 hours following initiation of the inflammatory response, and remained at high levels through to the last sample collected at 48 hours. This is in marked contrast to prostaglandin E2 concentrations which were low initially, peaked at four to eight hours and had returned to low levels by 12 to 24 hours. It is likely that interleukin-1 and various proteinases are involved in the later stages of the inflammatory response, such as the tissue remodelling associated with wound repair, and control of this cytokine may be important in the progression from acute to chronic inflammation.
May
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Department of Veterinary Basic Sciences, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire.
Hooke
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Lees
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D000818:Animals; D002364:Caseins / Q000378:metabolism*; D015232:Dinoprostone / Q000032:analysis; D006734:Horse Diseases / Q000201:enzymology / Q000378:metabolism*; D006736:Horses; D007249:Inflammation / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*; D007375:Interleukin-1 / Q000032:analysis*; D008666:Metalloendopeptidases / Q000032:analysis*
D002364:Caseins; D007375:Interleukin-1; D008666:Metalloendopeptidases; D015232:Dinoprostone