Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig.
We have studied the effects of tachykinin-depletion on airway microvascular leakage induced by allergen challenge in ovalbumin-sensitised guinea pigs. Tachykinin-depletion was obtained by capsaicin pretreatment 1 week before inhaled allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Thus, sensory neuropeptides may not be important in allergen-induced acute airway microvascular leakage in guinea pig in vivo.
Lötvall
J O
JO
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Hui
K P
KP
Löfdahl
C G
CG
Barnes
P J
PJ
Chung
K F
KF
D000402:Airway Obstruction / Q000378:metabolism / Q000517:prevention & control; D000485:Allergens; D000818:Animals; D002199:Capillary Permeability; D002211:Capsaicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D015320:Tachykinins / Q000378:metabolism; D014132:Trachea / Q000098:blood supply / Q000378:metabolism
D000485:Allergens; D015320:Tachykinins; D002211:Capsaicin