Obsessive-compulsive disorder and schizophrenia in three identical twin pairs.
Three monozygotic twin pairs are described who are concordant for DSM-III-R obsessive-compulsive disorder while being discordant for schizophrenia or schizoaffective disorder. Follow-up interview showed the non-psychotic co-twins to have schizotypal personality disorder. It is concluded that obsessive-compulsive and schizophrenia-spectrum disorders can truly co-exist, thus supporting diagnostic changes introduced into DSM-III-R, and may in some cases be inherited together.
Lewis
S W
SW
Department of Psychiatry, Charing Cross and Westminister Medical School, London.
Chitkara
B
B
Reveley
A M
AM
D000328:Adult; D016241:Child of Impaired Parents / Q000523:psychology; D003702:Delusions / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D010553:Personality Development; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D012931:Social Environment; D014430:Twins, Monozygotic / Q000523:psychology