Urinary output of endogenous monoamine oxidase inhibitor and isatin during acute migraine attacks.
Urinary output of endogenous monoamine oxidase (MAO) inhibitory activity, was significantly raised in serial samples collected across a migraine attack compared with collections during attack-free periods and in healthy controls, which did not differ from each other. There was a highly significant correlation in output between isatin, a major fraction of the MAO inhibitory activity, and output of the MAO inhibitory activity itself. However, although there was a tendency towards increased isatin excretion during migraine attacks, it failed to reach statistical significance.
Jarman
J
J
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
Przyborowska
A
A
Glover
V
V
Halket
J
J
Davies
P T
PT
Rose
F C
FC
Sandler
M
M
D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007510:Isatin / Q000652:urine*; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000209:etiology / Q000652:urine*; D008996:Monoamine Oxidase Inhibitors / Q000652:urine*; D011433:Propranolol / Q000627:therapeutic use; D013315:Stress, Psychological / Q000150:complications / Q000652:urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin; D011433:Propranolol; D003404:Creatinine