title: Immunity induced in rats vaccinated with toxoid prepared from heat-labile toxin produced by Pasteurella multocida serogroup D.
abstract: Rats were vaccinated with a toxoid (D-toxoid) prepared from purified heat-labile toxin (D-toxin) produced by Pasteurella multocida serogroup D. Vaccination of rats with D-toxoid prevented death and other effects of D-toxin (hepatic necrosis, development of elevated leukocyte counts, lymphopenia, neutrophilia, and elevated complement titers) that occurred in phosphate buffered saline (PBS)-vaccinated control rats.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010.
authors.forename: J R
authors.initials: JR
authors.lastname: Thurston
authors.forename: R B
authors.initials: RB
authors.lastname: Rimler
authors.forename: M R
authors.initials: MR
authors.lastname: Ackermann
authors.forename: N F
authors.initials: NF
authors.lastname: Cheville
authors.forename: J M
authors.initials: JM
authors.lastname: Sacks
mesh_terms: D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000276:immunology* / Q000633:toxicity; D003165:Complement System Proteins / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D007958:Leukocyte Count; D008099:Liver / Q000187:drug effects; D008297:Male; D010325:Pasteurella / Q000276:immunology*; D051381:Rats; D012044:Regression Analysis; D014121:Toxoids / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; C062258:Pasteurella multocida toxin; D014121:Toxoids; D003165:Complement System Proteins