Homologs of eleven loci on human chromosome 11 assigned to two owl monkey chromosomes.
We localized 11 loci mapped to human chromosome 11 to two chromosomes, 4 and 19 of owl monkey karyotype VI (2n = 49/50), by the use of somatic cell hybrids. Furthermore, using in situ hybridization to chromosomes of two owl monkey karyotypes, the HSTF1 oncogene locus was precisely localized on homologs 19q (K-VI) and 2q (K-II). Comparative analysis of available gene-mapping data among human, mouse, and owl monkey chromosomes revealed a pattern of evolutionary change in a syntenic group on human chromosome 11. These structural changes could be explained as having derived from a pericentric inversion of human chromosome region 11cen----q13 and a translocation involving human region 11q22----qter during primate evolution.
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New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
Gerhard
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Bock
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D000818:Animals; D001029:Aotus trivirgatus / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization