title: [Antifungal and fungicidal activities of tea extract and catechin against Trichophyton].
abstract: We examined tea extract, (-) epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) for their antifungal and fungicidal activities against Trichophyton mentagrophytes, T. rubrum, Candida albicans and Cryptococcus neoformans. Tea extract (2.5%) inhibited completely the growth of both T. mentagrophytes and T. rubrum. EGCg at 2.5 mg/ml failed to inhibit their growth, whereas TF3 at 0.5 mg/ml inhibited the growth. EGCg (1mg/ml) showed no fungicidal activity against Trichophyton. TF3 (1mg/ml) killed Trichophyton by a long time contact (72-96 hrs). Tea extract showed a fungicidal activity against Trichophyton in a dose- and contact time-dependent manner. It did not inhibit the growth of C. albicans, but at a high concentration, inhibited slightly the growth of C. neoformans. It had no fungicidal activity against C. albicans or C. neoformans.
authors.affiliation: Department of Bacteriology and Immunology, Showa University School of Medicine, Tokyo.
authors.forename: S
authors.initials: S
authors.lastname: Okubo
authors.forename: M
authors.initials: M
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Shimamura
mesh_terms: D000935:Antifungal Agents; D044946:Biflavonoids; D002392:Catechin / Q000031:analogs & derivatives*; D005419:Flavonoids / Q000494:pharmacology*; D013662:Tea; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D044946:Biflavonoids; D005419:Flavonoids; D013662:Tea; C056068:theaflavin; D002392:Catechin; C057580:gallocatechol