title: Liver failure attributable to pyrrolizidine alkaloid toxicosis and associated with inspiratory dyspnea in ponies: three cases (1982-1988).
abstract: Of 41 equids referred to a veterinary teaching hospital in the Pacific northwest because of dyspnea and inspiratory noise, 3 ponies were diagnosed as having liver failure, most likely attributable to pyrrolizidine alkaloid toxicosis. Dyspnea appeared to be caused by laryngeal and/or pharyngeal paralysis. It is proposed that this paralysis was a manifestation of hepatic encephalopathy. Although these clinical signs are not common for pyrrolizidine toxicosis, practitioners should be aware of the possibility so that misdiagnosis of other causes of inspiratory dyspnea may not be made.
authors.affiliation: Veterinary Teaching Hospital, College of Veterinary Medicine, Oregon State University, Corvallis 97331-4803.
authors.forename: E G
authors.initials: EG
authors.lastname: Pearson
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004417:Dyspnea / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D008107:Liver Diseases / Q000150:complications / Q000662:veterinary*; D008297:Male; D010947:Plants, Toxic; D011763:Pyrrolizidine Alkaloids / Q000506:poisoning*; D012189:Retrospective Studies; D012674:Senecio; D014826:Vocal Cord Paralysis / Q000150:complications / Q000662:veterinary
chemical_list: D011763:Pyrrolizidine Alkaloids