Effects of sodium o-iodobenzoate on acid-base parameters and survival in dogs with hemorrhagic shock.
Sodium o-iodobenzoate (OISB) produces an increase in P50 (PO2 at 50% of oxyhemoglobin saturation) and survival when infused at the time of initiation of prolonged hemorrhagic shock in dogs. Acid-base parameters improved during treatment, and plasma lactic acid concentrations showed smaller rises than in nontreated control animals. Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) rose in prolonged hemorrhagic shock in the control group and conversely decreased in OISB-treated dogs. OISB did not require red cell integrity, since its effects were still more marked in hemolyzed blood. The therapeutic benefit of OISB, appears to be related to a direct effect of the agent on the hemoglobin molecule.
Bercovich
C F
CF
Laboratorio de Sustancias Vasoactivas, Facultad de Medicina, Universidad de Buenos Aires, República Argentina.
Pirola
C J
CJ
Finkielman
S
S
Nahmod
V E
VE
D019794:2,3-Diphosphoglycerate; D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D007463:Iodobenzoates / Q000627:therapeutic use*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010100:Oxygen / Q000097:blood; D012771:Shock, Hemorrhagic / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D001639:Bicarbonates; D004163:Diphosphoglyceric Acids; D007463:Iodobenzoates; D007773:Lactates; D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; C023675:2-iodobenzoic acid; D010100:Oxygen