title: Desmin as an immunochemical marker of human decidual cells and its expression in menstrual fluid.
abstract: The expression of intermediate filament proteins in human endometrial tissue was examined. Desmin was selectively expressed in decidualized stroma, as demonstrated by SDS-PAGE analysis and positive response with a monoclonal antibody specific for desmin in ELISA and in western blot analysis. The same monoclonal antibody specifically stained human decidual cells in decidualized endometrium (secretory endometrium) in formalin-fixed paraffin-embedded sections prepared from diagnostic curettage samples. Desmin was also detected in menstrual fluid. Therefore, desmin might serve as a biochemical and histochemical marker of human decidualized endometrium.
authors.affiliation: Department of Obstetrics and Gynaecology, Sackler School of Medicine, Tel-Aviv University, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Halperin
authors.forename: G
authors.initials: G
authors.lastname: Fleminger
authors.forename: P F
authors.initials: PF
authors.lastname: Kraicer
authors.forename: E
authors.initials: E
authors.lastname: Hadas
mesh_terms: D015415:Biomarkers; D015153:Blotting, Western; D001826:Body Fluids / Q000737:chemistry*; D003656:Decidua / Q000737:chemistry* / Q000166:cytology; D003893:Desmin / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008598:Menstruation / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D003893:Desmin