[Correlations of convulsive and hypoxic resistance in rats at different stages of ontogenesis].
Hypoxic and convulsive resistances were studied in 3, 7, 14, 21, 40-day-old rats and in adults. Susceptibility to hypoxia was determined in pressure chamber by "lifting" the animals to the altitude of 12,000 metres. Convulsions were caused by intraabdominal injections of corazol. A correlation between hypoxic and convulsive resistances was found from 3 day after the birth. Their indexes were maximum at this period. Similar decrease of hypoxic and convulsive resistances was observed with the growth of the animals. Moreover the reduction in hypoxic resistance was more dramatic and reached its minimum on the 40th day. In grown up animals, resistance to hypoxia was higher, than in 40-day-old rats. Minimum latency period for development of status epilepticus was detected in 21-day-old rats.
Agadzhanian
N A
NA
Torshin
V I
VI
Starykh
E V
EV
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001273:Atmosphere Exposure Chambers; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D000860:Hypoxia / Q000209:etiology / Q000517:prevention & control*; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D010433:Pentylenetetrazole
Korreliatsiia sudorozhnoĭ i gipoksicheskoĭ ustoĭchivosti u krys na raznykh stadiiakh ontogeneza.