title: Script generation as an indicator of knowledge representation in patients with Alzheimer's disease.
abstract: We examined script and lexical retrieval in patients with probable Dementia-Alzheimer's Type (DAT), Depressed patients, and normal controls. DAT patient breakdown in script production was structurally similar to their impaired lexical retrieval such that script events of low frequency and low centrality value were lost first. DAT patients also produced more events that fell outside the script boundary as well as more event-order errors. Four cases with DAT were identified on the basis of Z scores whose script production was at least 2 SDs greater than their lexical production or vice versa. This finding suggests that it may be possible to dissociate script and lexical knowledge and production processes. The findings lend partial support for a model of knowledge representation that includes parallel and partially redundant memory networks that are distinctly distributed in the brain.
authors.affiliation: Cognitive Neuroscience Section, NINDS, NIH, Bethesda, Maryland 20892.
authors.forename: J
authors.initials: J
authors.lastname: Grafman
authors.forename: K
authors.initials: K
authors.lastname: Thompson
authors.forename: H
authors.initials: H
authors.lastname: Weingartner
authors.forename: R
authors.initials: R
authors.lastname: Martinez
authors.forename: B A
authors.initials: BA
authors.lastname: Lawlor
authors.forename: T
authors.initials: T
authors.lastname: Sunderland
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D003210:Concept Formation; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D012691:Serial Learning; D013068:Speech Production Measurement; D014706:Verbal Learning