Evaluation of a new calcium containing cardioplegic solution in the isolated rabbit heart in comparison to a calcium-free, low sodium solution.
Isolated perfused rabbit hearts were studied to compare the effects of 3 hour ischemic arrest following either calcium-free or calcium-containing cardioplegia, on the recovery of isovolumic function of the left ventricle, coronary flow, release of creatine phosphokinase and myocardial water content. The hearts perfused with the calcium-containing solution (Ca 0.5 mmol/L) showed better recovery of the developed pressure in the left ventricle, and its first derivative and compliance. Coronary flow at a constant perfusion pressure was better restored during reperfusion in the hearts with calcium-containing solution. The release of less CPK and a lower water content were also observed in the hearts reperfused with calcium-containing solution. We concluded that calcium-containing cardioplegic solution with a high concentration of magnesium (10 mmol/L) was superior to calcium-free solution for myocardial protection.
Mori
F
F
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
Suzuki
K
K
Noda
H
H
Kato
T
T
Tsuboi
H
H
Miyamoto
M
M
Esato
K
K
Imamura
A
A
Kawahara
S
S
Uchiyama
J
J
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D003326:Coronary Circulation / Q000502:physiology; D006324:Heart Arrest, Induced; D008274:Magnesium / Q000494:pharmacology; D015425:Myocardial Reperfusion; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
D002314:Cardioplegic Solutions; D012964:Sodium; D008274:Magnesium; D002118:Calcium