Comparative kinetics of serum and vitreous humor digoxin concentrations in a guinea pig model. Part I: Intravenous administration of digoxin.
The pharmacokinetics of a single intravenous dose of digoxin in the guinea pig was investigated with emphasis on the penetration of digoxin into the vitreous humor. A controlled study was undertaken and data was collected which indicated that digoxin follows an open, two-compartment pharmacokinetic model with a terminal half-life of 318 minutes. The data indicated that the ratio of vitreous concentrations to serum concentrations were determined to be equal following an initial tissue distribution phase.
Donnelly
B
B
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439.
Balkon
J
J
Bidanset
J H
JH
Belmonte
A
A
Barletta
M
M
Manning
T
T
D000818:Animals; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D007202:Indicators and Reagents; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D014822:Vitreous Body / Q000737:chemistry / Q000378:metabolism*
D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D004077:Digoxin