title: Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.
abstract: Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
authors.affiliation: Department of Psychogeriatrics, Mossley Hill Hospital, Liverpool.
authors.forename: K
authors.initials: K
authors.lastname: Wilson
authors.forename: D
authors.initials: D
authors.lastname: Bowen
authors.forename: P
authors.initials: P
authors.lastname: Francis
authors.forename: P
authors.initials: P
authors.lastname: Tyrrell
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000523:psychology; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000187:drug effects; D006801:Humans; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D010091:Oximes; D010830:Physostigmine / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D010830:Physostigmine