Disseminated histoplasmosis in a renal transplant patient: a cause of renal failure several years following transplantation.
A 49-year-old man developed disseminated histoplasmosis 6 1/2 years after transplantation. The organism was initially present in the urine and in a tongue lesion. Treatment with itraconazole was instituted. However, there was further dissemination of the disease and worsening of renal function. Allograft biopsy showed extensive involvement with the organism. Amphotericin B was started, resulting in a rapid resolution of the disease. However, renal function deteriorated, leading to permanent hemodialysis.
Sridhar
N R
NR
Department of Medicine, University of Cincinnati College of Medicine, OH 45267-0585.
Tchervenkov
J I
JI
Weiss
M A
MA
Hijazi
Y M
YM
First
M R
MR
D001706:Biopsy; D006084:Graft Rejection; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D011183:Postoperative Complications / Q000382:microbiology / Q000473:pathology*; D013997:Time Factors