Effects of triamcinolone acetonide on plasma amino acids and urinary urea output in rabbits.
1. The effect of administering triamcinolone acetonide (10 mg/kg/day), 6 consecutive s.c. injections given daily, on plasma free amino acids and urinary urea output was studied in rabbits. 2. The total free amino acids in plasma decreased significantly from day 2 while ammonia increased significantly only on day 2, glutamine, lysine and branched amino acids increased significantly from day 3 or 5. 3. The output of urinary urea increased significantly from day 3. 4. These findings suggest the inhibition of protein synthesis observed in steroid myopathy may result from a decrease in the amino acid pool in skeletal muscle.
Shoji
S
S
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D005260:Female; D007700:Kinetics; D009132:Muscles / Q000378:metabolism; D011817:Rabbits; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D014508:Urea / Q000652:urine*
D000596:Amino Acids; D014508:Urea; D014222:Triamcinolone Acetonide