title: The clinical significance of biological characteristics of the cells in acute myeloid leukemia.
abstract: An understanding of the biological heterogeneity of acute myeloid leukemia has been gained from studies of morphology, cytogenetics, cell surface antigen expression, level of leukemic transformation, responsiveness to hematopoietic growth factors, in vivo and in vitro differentiation, and protooncogene expression. Knowledge acquired from these studies has begun to lead to stratification of therapy and to new avenues of treatment.
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: M R
authors.initials: MR
authors.lastname: Baer
authors.forename: C D
authors.initials: CD
authors.lastname: Bloomfield
mesh_terms: D002454:Cell Differentiation; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D011519:Proto-Oncogenes / Q000235:genetics