Electrochemical reduction of arylethenylpyridinium salts: relation to structure and anthelmintic activity.
Cyclic voltammetry data were obtained for a series of 1(1-)- and 1(2-arylethenyl)pyridinium salts. The 1(1-arylvinyl) salts exhibited more negative reduction potentials than their N-beta-styryl counterparts. Rationalizations of the reduction values are provided. Differences in reduction potentials within a series are discussed utilizing substituent constant effects. Correlations exist for the electrochemical data and anthelmintic activity.
Ames
J R
JR
Department of Chemistry, University of Michigan-Flint 48502-2186.
D000818:Animals; D000871:Anthelmintics / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009351:Nematospiroides dubius / Q000187:drug effects; D010084:Oxidation-Reduction; D010124:Oxyuroidea / Q000187:drug effects; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D011726:Pyridinium Compounds