[Clinical findings in newborn infants of mothers with kidney transplants].
Renal transplant patients who become pregnant require continued immunosuppression. Little is known on the risk of infants born under these conditions. We observed 6 neonates of renal transplant patients, of whom 4 were premature and 3 small for gestational age (SGA). There were no congenital malformations. Transient thrombopenia in 1 preterm baby probably resulted from maternal immunosuppression. Further 232 cases were published since 1980. Among the total of 238 patients, including our observations, rates for prematurity (49%) and SGA-infants (29%) were high, 6% had congenital malformations. Maternal immunosuppression with Cyclosporin A, as compared to Azathioprine, seems to carry a higher risk of prematurity (66 vs. 43%) and SGA-babies (56 vs. 19%). On the contrary, Azathioprine might be more muta- and teratogenic. At present, no data are available on the long-term outcome of these children.
Pabelick
C
C
Abteilung für Allgemeine Pädiatrie, Universitäts-Kinderklinik, Düsseldorf.
Kemmer
F
F
Koletzko
B
B
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006084:Graft Rejection / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011183:Postoperative Complications / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D012307:Risk Factors; D016216:Ultrasonography, Prenatal
D003524:Cyclosporins; D011239:Prednisolone; D001379:Azathioprine; D008775:Methylprednisolone
Befunde bei Neugeborenen nierentransplantierter Mütter.