title: How prevalent is cancer family syndrome?
abstract: Based on an established but pragmatic definition of cancer family syndrome as the presence of three or more relatives affected by colorectal cancer in a first degree kinship, the contribution of this syndrome to the total cancer burden in Northern Ireland has been studied by investigating all non-polyposis probands under 55 years old at histological diagnosis between 1976 and 1978. Family interviews were possible for 95% (n = 205) of all non-polyposis probands and verification of vital status or medical history was obtained for 98% of 1811 first degree relatives. The prevalence of cancer family syndrome was between 1 and 2%, a figure some fivefold less than that estimated elsewhere. A proximal tumour excess was not characteristic of the ascertained families. These results may have implications for the identification of susceptible people if screening for high risk groups is considered a worthwhile option for reducing colorectal cancer mortality in the United Kingdom.
authors.affiliation: Department of Epidemiology and Public Health, Queen's University of Belfast.
authors.forename: F
authors.initials: F
authors.lastname: Kee
authors.forename: B J
authors.initials: BJ
authors.lastname: Collins
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology* / Q000235:genetics; D004198:Disease Susceptibility; D006801:Humans; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D015995:Prevalence