Secretion of triglyceride and ketogenesis by livers from spontaneous diabetic BB Wistar rats.
Livers from male and female BB Wistar spontaneously diabetic rats were perfused in vitro to determine the effects of spontaneously occurring insulin-dependent diabetes on the metabolism of fatty acid. The secretion of triglyceride and the incorporation of [1-14C] oleic acid into perfusate and hepatic triglyceride was reduced by the diabetic state, whereas beta-hydroxybutyrate production and output of total ketone bodies were increased. The spontaneous diabetic Wistar rat clearly is a suitable model to study the derangements induced in lipid/plasma lipoprotein metabolism by the insulin-dependent diabetic state; the data obtained with this model confirm our earlier observations on experimental insulin deficiency induced with alloxan, streptozotocin, and anti-insulin serum.
Weinstein
I
I
Department of Pharmacology College of Medicine, University of Tennessee, Memphis.
Patel
T B
TB
Heimberg
M
M
D020155:3-Hydroxybutyric Acid; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D005260:Female; D006885:Hydroxybutyrates / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D051381:Rats; D011913:Rats, Inbred BB; D014280:Triglycerides / Q000378:metabolism*
D006885:Hydroxybutyrates; D007657:Ketone Bodies; D009829:Oleic Acids; D014280:Triglycerides; D019301:Oleic Acid; D020155:3-Hydroxybutyric Acid