On the identification of a conjugated diene component of duodenal bile as 9Z,11E-octadecadienoic acid.
The lipid free radical marker, termed diene conjugation, in secretin-stimulated human bile obtained from the duodenum, was shown by high performance liquid chromatography and capillary gas chromatography-mass spectrometry, to be due mainly to 9Z,11E-octadecadienoic acid. The lack of evidence for possible conjugated diene isomers argues for an enzymatic origin of this product rather than being due to a random free radical mechanism, as is usually assumed.
Smith
G N
GN
Department of Chemistry, University of Manchester, England.
Taj
M
M
Braganza
J M
JM
D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated; D012633:Secretin / Q000494:pharmacology
D001647:Bile Acids and Salts; D015415:Biomarkers; D005609:Free Radicals; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D012633:Secretin; C046938:9,11-linoleic acid