Male-specific metabolism of simvastatin by rat liver microsomes.
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.
Uchiyama
N
N
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Kagami
Y
Y
Saitoh
Y
Y
Ohtawa
M
M
D000818:Animals; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D019821:Simvastatin
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin