Anti-idiotypic antibodies in patients with monoclonal gammopathies: relation to the tumour load.
The production of anti-idiotypic antibodies from Epstein-Barr virus transformed peripheral blood lymphocytes was analysed in 12 patients with multiple myeloma and monoclonal gammopathy of undetermined significance. A low anti-idiotype production was found in patients with advanced disease (multiple myeloma stage III), whereas the production was high in patients with multiple myeloma stage I and monoclonal gammopathy of undetermined significance (MGUS) (P less than 0.01). The study supports the existence of an immunological network response in patients with monoclonal gammopathies.
Bergenbrant
S
S
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Osterborg
A
A
Holm
G
G
Mellstedt
H
H
Lefvert
A K
AK
D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007128:Immunoglobulin Fragments / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000032:analysis*; D008213:Lymphocyte Activation / Q000276:immunology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology; D009367:Neoplasm Staging; D010265:Paraproteinemias / Q000276:immunology* / Q000473:pathology
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M