title: Influence of dietary-induced copper and manganese deficiency on ozone-induced changes in lung and liver antioxidant systems.
abstract: The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
authors.affiliation: Department of Nutrition, University of California, Davis 95616.
authors.forename: S
authors.initials: S
authors.lastname: Zidenberg-Cherr
authors.forename: B
authors.initials: B
authors.lastname: Han
authors.forename: M A
authors.initials: MA
authors.lastname: Dubick
authors.forename: C L
authors.initials: CL
authors.lastname: Keen
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000172:deficiency*; D004032:Diet; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008345:Manganese / Q000172:deficiency*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010126:Ozone / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008345:Manganese; D010126:Ozone; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione