Opposite action of oxytocin and its peptide antagonists on social memory in rats.
The synthetic 1-beta,beta-disubstituted analogues of [1-deamino]-oxytocin, [1'-(1'-thio-4'-methylcyclohexane)-acetic acid 1]-oxytocin (MeCAOT) a peripheral oxytocin antagonist, and [1'-(1'-methyl-4'-thiopiperidine)-acetic acid 1]-oxytocin (MePAOT), devoid of peripheral anti-oxytocin activity, were found to improve social memory of rats. The social memory in rats was disrupted by a wide range of doses of oxytocin (6-750 mU/kg) and this amnestic effect of oxytocin was antagonised by MePAOT and MeCAOT.
Popik
P
P
Polish Academy of Sciences, Institute of Pharmacology, Kraków.
Vetulani
J
J
D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects*; D010121:Oxytocin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
C055082:oxytocin, 1'-(1'-thio-4'-methylcyclohexane)acetic acid-; C055080:oxytocin, 1'-(1'-methyl-4'-thiopiperidine)acetic acid-; D010121:Oxytocin