[Trace elements in the pathogenesis and treatment of chronic bronchitis (a clinico-experimental study)].
Experiments on healthy male rats and those with chronic inflammation in the bronchi (CIB) were made to measure the content of testosterone, estradiol, zinc and copper in the blood and in the liquid of bronchoalveolar lavage (LBAL) as well as in the vitally important organs. Attempts were also made to equalize the content of trace elements by means of medicamentous correction in patients suffering from chronic obstructive bronchitis (COB). In CIB, there was a decrease of testosterone concentration in the blood and of zinc concentration in the plasma and formed elements of the blood, lungs, heart, liver, testes and adrenals (p less than 0.05). The zinc level in the LBAL was two times higher, that of copper was three times lower. After zinc sulfate was included into a complex of treatment measures for COB patients, zinc and copper concentrations in the plasma and formed elements of the blood returned to normal in addition to the improvement of the general health status. In the reference group of patients who received conventional symptomatic treatment, the given parameters did not noticeably change.
Tadzhiev
F S
FS
D000818:Animals; D001991:Bronchitis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D002908:Chronic Disease; D003300:Copper / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000378:metabolism; D015032:Zinc / Q000378:metabolism* / Q000627:therapeutic use
D013739:Testosterone; D004958:Estradiol; D003300:Copper; D015032:Zinc
Mikroélementy v patogeneze i lechenii khronicheskogo bronkhita (kliniko-éksperimental'noe issledovanie).