Peptide amidation.
Many hormones, neurotransmitters and growth factors are peptides that carry an amide group at their carboxyl terminus which is essential for their biological activity. The amide is formed by hydroxylation of an additional glycine residue present in the biosynthetic precursor and the hydroxyglycine derivative dissociates to form the peptide amide and glyoxylic acid. Recent discoveries have shown that two enzymes are involved that act sequentially.
Bradbury
A F
AF
National Institute for Medical Research, Mill Hill, London, UK.
Smyth
D G
DG
D019760:Amidine-Lyases; D000586:Amination; D000818:Animals; D006836:Hydro-Lyases / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D008956:Models, Chemical; D009097:Multienzyme Complexes; D010455:Peptides / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D009097:Multienzyme Complexes; D010455:Peptides; D006899:Mixed Function Oxygenases; C035189:peptidylglycine monooxygenase; D006836:Hydro-Lyases; D019760:Amidine-Lyases; C068521:peptidylamidoglycolate lyase