[Decreased 67-gallium plasma protein binding in senile dementia of the Alzheimer type].
We examined the plasma-protein-binding of 67-gallium in 10 patients with probable dementia of the Alzheimer-type (DAT), diagnosed according to NINCDS-ADRDA-criteria, and in 10 healthy controls matched for age (mean: 82 and 83 years) and sex (2m:8f). In comparison to the control group, the percentage of 67-gallium bound in the plasma of DAT-patients was significantly decreased (10.6% vs 15.5%; p less than 0.05). As gallium and aluminum show corresponding biochemical characteristics, these results may indicate a potential contribution of a disturbed peripheral transport in DAT, leading to the intracerebral deposition of neurotoxic aluminum levels.
Förstl
H
H
Section of Old Age, Institute of Psychiatry, London, United Kingdom.
Brammer
M
M
Burns
A
A
Richmond
S
S
Levy
R
R
D000368:Aged; D000369:Aged, 80 and over; D000535:Aluminum / Q000493:pharmacokinetics*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D011485:Protein Binding / Q000502:physiology*; D011877:Radionuclide Imaging; D012307:Risk Factors
D005710:Gallium Radioisotopes; D000535:Aluminum
Erniedrigte 67-Gallium-Plasma-Protein-Bindung bei seniler Demenz vom Alzheimer-Typ.