T-cell reactivity to purified lipophosphoglycan from Leishmania major: a model for analysis of the cellular immune response to microbial carbohydrates.
The major macromolecule on the surface of Leishmania major promastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of parasites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell stimulation by this non-protein antigen.
Moll
H
H
Institut für Klinische Mikrobiologie, Universität Erlangen-Nürnberg, Erlangen, Germany.
Röllinghoff
M
M
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D006028:Glycosphingolipids / Q000276:immunology*; D006790:Host-Parasite Interactions; D007111:Immunity, Cellular; D007895:Leishmania tropica / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D011425:Propionibacterium acnes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000953:Antigens, Protozoan; D006028:Glycosphingolipids; D008222:Lymphokines; C008290:lipophosphonoglycan