Effect of non-beta-lactam antibiotics on penicillin-binding protein synthesis of Enterococcus hirae ATCC 9790.
Fosfomycin, bacitracin and vancomycin in combination with penicillin exhibit a synergic effect against Enterococcus hirae ATCC 9790. This strain, when incubated in presence of the MIC of non-beta-lactam antibiotics, showed an alternated pattern of PBPs. Bacitracin and vancomycin caused a decrease in the density of all PBPs while fosfomycin only reduced that of PBP 6. It is suggested that the observed synergy is a consequence of the inhibition of PBP synthesis by antibiotics which act on the early stages of peptidoglycan synthesis prior to the formation of cross-links.
Grossato
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Institute of Microbiology, University of Padua, Italy.
Sartori
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Fontana
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D001414:Bacitracin / Q000494:pharmacology*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000096:biosynthesis*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology*; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000096:biosynthesis*; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism*; D010458:Peptidyl Transferases; D013045:Species Specificity; D013291:Streptococcus / Q000378:metabolism*; D014640:Vancomycin / Q000494:pharmacology*
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D001414:Bacitracin; D005578:Fosfomycin; D014640:Vancomycin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase