title: Influence of the injection site on the tumorigenicity of a cloned colon tumor cell line in the rat.
abstract: The cloned DHD/K12/TSb line obtained from a chemically-induced rat colon carcinoma, presents tumors which always regress when injected subcutaneously to the syngeneic animal. This study reports that an intraperitoneal injection of the DHD/K12/TSb cells induces a progressive carcinomatosis in a high proportion of the syngeneic rats. This result underlines the effect that the local environment has on tumorigenicity.
authors.affiliation: Groupe de recherche sur les cancers digestifs, Inserm U252, Faculté de médecine, Dijon, France.
authors.forename: D
authors.initials: D
authors.lastname: Reisser
authors.forename: C
authors.initials: C
authors.lastname: Fady
authors.forename: P
authors.initials: P
authors.lastname: Lagadec
authors.forename: F
authors.initials: F
authors.lastname: Martin
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed / Q000187:drug effects; D002999:Clone Cells; D003110:Colonic Neoplasms / Q000473:pathology*; D004333:Drug Administration Routes; D005260:Female; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D009857:Oncogenes; D051381:Rats; D011919:Rats, Inbred Strains