title: Paralytic and insecticidal toxins from the funnel web spider, Hololena curta.
abstract: One peptide and ten acylpolyamine toxins (curtatoxins) were purified and identified from venom of Hololena curta. The acylpolyamines consist of six different polyamines which are amidated with three different aromatic acids: (3-indolyl)acetic, (4-hydroxy-3-indolyl)acetic and 2.5-dihydroxybenzoic acids. These acylpolyamines instantly paralyze lepidopteran larvae following injection. The most potent insecticidal peptide in H. curta venom contains 38 amino acids and is lethal at 4 micrograms/g when injected into Manduca sexta larvae.
authors.affiliation: Sandoz Crop Protection Corporation, Palo Alto, CA 94304-1104.
authors.forename: G B
authors.initials: GB
authors.lastname: Quistad
authors.forename: C C
authors.initials: CC
authors.lastname: Reuter
authors.forename: W S
authors.initials: WS
authors.lastname: Skinner
authors.forename: P A
authors.initials: PA
authors.lastname: Dennis
authors.forename: S
authors.initials: S
authors.lastname: Suwanrumpha
authors.forename: E W
authors.initials: EW
authors.lastname: Fu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D007306:Insecticides / Q000302:isolation & purification*; D007814:Larva; D008969:Molecular Sequence Data; D009036:Moths / Q000187:drug effects; D009498:Neurotoxins / Q000302:isolation & purification* / Q000633:toxicity; D010243:Paralysis / Q000139:chemically induced; D013111:Spider Venoms / Q000032:analysis*
chemical_list: D007306:Insecticides; D009498:Neurotoxins; D013111:Spider Venoms