Possible linkage of the estrogen receptor gene to breast cancer in a family with late-onset disease.
The estrogen-receptor locus is a candidate gene for inherited susceptibility to human breast cancer, particularly among families with later onset, primarily estrogen-receptor-positive tumors. For one extended family with eight patients with late-onset disease, one estrogen-receptor haplotype was consistently coinherited with breast cancer, yielding a +1.85 lod score for linkage at zero recombination. Simulation of this pedigree assuming independent inheritance of breast cancer and estrogen-receptor genotypes led to a lod score greater than or equal to 1.85 only once in 2,000 replicates. We suggest testing linkage of this gene to breast cancer in other families with late-onset disease.
Zuppan
P
P
School of Public Health, University of California, Berkeley 94720.
Hall
J M
JM
Lee
M K
MK
Ponglikitmongkol
M
M
King
M C
MC
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004198:Disease Susceptibility; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D011960:Receptors, Estrogen; D004247:DNA