Elevation of plasma concentrations of haloperidol after the addition of fluoxetine.
Fluoxetine (20 mg/day) was added for 7-10 days to stable doses of haloperidol given to eight psychotic patients. Mean plasma concentrations of haloperidol were elevated by 20% (p less than 0.05), but extrapyramidal side effects did not increase appreciably, indicating a relatively minor interaction between these agents.
Goff
D C
DC
Erich Lindemann Mental Health Center, Boston, Mass.
Midha
K K
KK
Brotman
A W
AW
Waites
M
M
Baldessarini
R J
RJ
D000328:Adult; D000368:Aged; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D006220:Haloperidol / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013268:Stimulation, Chemical
D005473:Fluoxetine; D006220:Haloperidol