Effect of a non-protein fraction from an extract of the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin) on Meth A-induced delayed type hypersensitivity.
The effect of a non-protein fraction from an extract of inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin, NSP) was studied on Meth A tumor-induced delayed type hypersensitivity (Meth A-DTH) in BALB/c mice. NSP enhanced the Meth A-DTH. NSP also enhanced the DTH suppressed with 5-fluorouracil (5-FU). Moreover, NSP inhibited the fatal effect of 5-FU and restored the decrease of body weight caused by 5-FU. However, NSP reduced partially but significantly the suppression of the tumor growth by 5-FU. NSP may be useful for cancer treatment in combination with chemotherapeutic agents, if NSP does not inhibit their antitumor activity.
Mori
H
H
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Kurimoto
Y
Y
Xu
Q A
QA
Koda
A
A
D000818:Animals; D005472:Fluorouracil / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits; D014020:Tissue Extracts / Q000494:pharmacology*
D011134:Polysaccharides; D014020:Tissue Extracts; C010491:neurotropin; D005472:Fluorouracil