title: Histamine and leukotriene concentrations in duodenal tissue and mucus of lambs selected for high and low responsiveness to vaccination and challenge with Trichostrongylus colubriformis.
abstract: Lambs selectively bred for high responsiveness or low responsiveness to vaccination with irradiated Trichostrongylus colubriformis were vaccinated and challenged. Duodenal tissue histamine concentrations in both high and low responder lambs were lower at 3 days than at 28 days after challenge. At 3 days after challenge, histamine concentrations were higher in both male and female high responder lambs than in low responder lambs whereas at 28 days concentrations were increased only in high responder females. At 3 days after challenge, histamine concentrations were generally lower in mucus than in tissues, but levels were again higher in mucus from high responder groups. In duodenal tissue at 3 days after challenge, leukotriene C4 and B4 concentrations were similar in high and low responder animals. At the same time, concentrations of both leukotrienes were higher in mucus than in tissues, with high responder female lambs having the highest concentration. It is suggested that increased levels of histamine and leukotrienes in mucus and tissue are associated with larval rejection or exclusion.
authors.affiliation: CSIRO Division of Animal Health, McMaster Laboratory, Glebe, New South Wales, Australia.
authors.forename: W O
authors.initials: WO
authors.lastname: Jones
authors.forename: R G
authors.initials: RG
authors.lastname: Window
authors.forename: J W
authors.initials: JW
authors.lastname: Steel
authors.forename: P M
authors.initials: PM
authors.lastname: Outteridge
mesh_terms: D000818:Animals; D004386:Duodenum / Q000276:immunology*; D005260:Female; D006632:Histamine / Q000032:analysis*; D015289:Leukotrienes / Q000032:analysis*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D014253:Trichostrongylosis / Q000276:immunology / Q000662:veterinary*; D014254:Trichostrongylus / Q000276:immunology; D014611:Vaccination / Q000662:veterinary
chemical_list: D015289:Leukotrienes; D006632:Histamine