[Chemoprophylaxis of Plasmodium falciparum malaria by a combination of 100 mg of chloroquine and 200 mg of proguanil per day in a zone III of chloroquine resistance (Gabon). Study of 431 French soldiers].
Incidence of P. falciparum malaria in french non-immune soldiers serving in Gabon for four months has increased from 21% in 1987 to 37% in 1988. Since 1989, in a first step, the personal protection measures were reinforced. Thereafter, the usual chemoprophylaxis (chloroquine 100 mg daily) was replaced by a daily association of chloroquine 100 mg and proguanil 200 mg. A 85% decrease of malaria incidence was observed in 431 soldiers. The effects of the personal protection strengthening and of the new chemoprophylaxis can be evaluated to be respectively responsible for 50% and 71% decrease. Among the secondary effects, gastric pain was the most frequent, but it was never a cause of chemoprophylaxis stopping. The mouth ulcer frequency was far lower than that elsewhere reported. No significant biological abnormalities could be related to the chloroquine-proguanil association.
Sarrouy
J
J
CHA H. Larrey, 31998 Toulouse Armées.
Cellier
C
C
Migliani
R
R
Todesco
A
A
Favier
G
G
Linden
L
L
Pull
J
J
Pascal
B
B
Baudon
D
D
Delolme
H
H
D000818:Animals; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005602:France / Q000208:ethnology; D005681:Gabon; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008889:Military Personnel; D010963:Plasmodium falciparum; D002727:Proguanil / Q000008:administration & dosage / Q000627:therapeutic use*
D002738:Chloroquine; D002727:Proguanil
Chimioprophylaxie du paludisme à Plasmodium falciparum par une association de 100 mg de chloroquine et de 200 mg de proguanil par jour dans une zone III de chloroquino-résistance (Gabon). Etude chez 431 militaires français.