title: Comparison of cell growth in different parts of breast cancers.
abstract: This study was performed to answer the question: which parts of breast cancers are active in terms of proliferation as measured by the Ki-67 antibody and in terms of cell division as measured by the mitotic index. Forty-six breast samples were studied, including 34 breast cancers and 12 benign conditions. The intraductal component of infiltrating breast cancers showed a significantly lower proliferation index than the infiltrating component. The cells at the periphery of infiltrating tumour strands showed a higher proliferation activity than the cells in the core. These findings suggest that infiltration advances through preferential active growth of the cells at the invasion front.
authors.affiliation: Department of Pathology, University Hospital, Antwerp, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Verhoeven
authors.forename: N
authors.initials: N
authors.lastname: Bourgeois
authors.forename: M P
authors.initials: MP
authors.lastname: Derde
authors.forename: L
authors.initials: L
authors.lastname: Kaufman
authors.forename: N
authors.initials: N
authors.lastname: Buyssens
mesh_terms: D000954:Antigens, Surface; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division; D006801:Humans; D019394:Ki-67 Antigen; D008940:Mitotic Index
chemical_list: D000954:Antigens, Surface; D019394:Ki-67 Antigen