[Early neutralization of heparin during heart surgery of acquired heart defects using perfusion-free hypothermia (28-24C)].
The analysis of blood loss in profound perfusion-free hypothermia has shown that its main cause is that heparin neutralization was performed only after the warming of a patient to 34-35 degrees C. The results of in vitro studies have shown that heparin was effectively neutralized by protamine sulfate at room temperature (20 degrees C). Using protamine sulfate, heparin neutralization was performed at 25-27 degrees C in 90 patients, which reduced blood loss by 10-15% of the circulating blood volume and made it possible to avoid hemotransfusions in the post-operative period.
Shchukin
V S
VS
Tsvetovskaia
G A
GA
Len'ko
E V
EV
Naumenko
S E
SE
Savikova
E A
EA
Naroushvili
T I
TI
Len'ko
O A
OA
D006348:Cardiac Surgical Procedures; D006494:Heparin Antagonists; D006801:Humans; D007036:Hypothermia, Induced; D011479:Protamines / Q000494:pharmacology*; D013997:Time Factors
D006494:Heparin Antagonists; D011479:Protamines
Ranniaia neĭtralizatsiia geparina pri kardiokhirurgicheskikh operatsii po povodu priobretennykh porokov serdtsa v usloviiakh besperfuzionnoĭ gipotermii (28-24C).