title: [The diagnostic significance of different blood parameters and liver biopsy in chronic copper poisoning of sheep].
abstract: In a flock of sheep to which food with excess copper (= Cu) had been fed for some months 39 animals died of chronic copper toxicosis. In 5 sheep of this flock the plasma concentrations of the enzymes glutamate dehydrogenase (GLDH), sorbitol dehydrogenase (SDH), aspartate-amino-transferase (ASAT) and copper were measured several times over a period of 100 days. At day 23, 58 and 97 needle biopsies of the liver were taken. The biopsies were used for histological examination and Cu-analysis. After 100 days the sheep were slaughtered and chronic copper poisoning was diagnosed by raised Cu concentration and typical histological alterations in the liver. The activities of GLDH and SDH in the plasma of the 5 sheep were consistently above normal, ASAT activity and the plasma Cu level were raised only occasionally. The results of Cu determination in biopsy samples were of little predictive value compared with post mortem Cu analysis of the liver.
authors.affiliation: Klinik für kleine Klauentiere und forensische Medizin der Tierärztlichen Hochschule Hannover.
authors.forename: M
authors.initials: M
authors.lastname: Ganter
authors.forename: K
authors.initials: K
authors.lastname: Bickhardt
authors.forename: N
authors.initials: N
authors.lastname: Stockhofe
authors.forename: J
authors.initials: J
authors.lastname: Kamphues
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001707:Biopsy, Needle / Q000662:veterinary; D003300:Copper / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology
chemical_list: D006454:Hemoglobins; D003300:Copper; D007064:L-Iditol 2-Dehydrogenase; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D001663:Bilirubin
vernacular_title: Zur diagnostischen Bedeutung verschiedener Blutmessgrössen und der Leberbiopsie bei der chronischen Kupfervergiftung des Schafes.