Immunological aspects of progeria (Hutchinson-Gilford syndrome) in a 15-month-old child.
A thorough analysis of the immunological status was conducted in a 15-month-old child with progeria (Hutchinson-Gilford syndrome). Total leukocyte and neutrophil counts were slightly increased, and monocytes were decreased. Percentage and numbers of CD4+ cells in the blood were mildly decreased as well as the CD4/CD8 cell ratio. CD20 (B-cell marker) bearing cells and cells bearing Ia-antigens were increased, as well as CD16 and CD56 marker-bearing cells (natural-killer cells, NK). Lymphocyte proliferation upon stimulation with phytohaemagglutinin and purified protein derivative were decreased, and with pokeweed mitogen increased. NK cell activity appeared increased, particularly at lower effector: target cell ratios.
Harjacek
M
M
Department of Paediatrics, University Hospital Rebro, Croatia, Yugoslavia.
Batinić
D
D
Sarnavka
V
V
Uzarević
B
B
Mardesić
D
D
Marusić
M
M
D000361:Agammaglobulinemia / Q000150:complications; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D011371:Progeria / Q000150:complications / Q000276:immunology*
D003165:Complement System Proteins