title: Double-blind randomized multicenter study comparing Maalox TC tablets and ranitidine in healing of duodenal ulcers.
abstract: The efficacy of ranitidine 150 mg twice daily and Maalox TC three tablets four times daily were compared in patients with endoscopically confirmed duodenal ulcer. Seventy-nine patients were randomly allocated to double-blind, double-dummy treatment, stratified for smokers. Endoscopy was repeated after four weeks. Those unhealed continued treatment for a further two weeks before final endoscopy. Per protocol analysis in 53 patients showed ulcer healing rates at week 4 and at weeks 4 and 6 combined of 78 and 89% on Maalox TC, and of 81 and 91% on ranitidine, respectively. The same analysis gave overall healing rates of 81% in smokers and 100% in nonsmokers, irrespective of treatment. Both treatments provided early ulcer pain relief. Diarrhea was a commoner side effect in patients on Maalox TC. The study showed Maalox TC and ranitidine were equally effective in healing duodenal ulceration.
authors.affiliation: Gastroenterology Research Unit, Addenbrooke's Hospital, Cambridge, U.K.
authors.forename: J O
authors.initials: JO
authors.lastname: Hunter
authors.forename: R J
authors.initials: RJ
authors.lastname: Walker
authors.forename: J
authors.initials: J
authors.lastname: Crowe
authors.forename: R R
authors.initials: RR
authors.lastname: Gillies
authors.forename: K R
authors.initials: KR
authors.lastname: Gillies
authors.forename: K R
authors.initials: KR
authors.lastname: Gough
authors.forename: S
authors.initials: S
authors.lastname: Lorber
mesh_terms: D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000627:therapeutic use*; D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008276:Magnesium Hydroxide / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011899:Ranitidine / Q000009:adverse effects / Q000627:therapeutic use*; D012907:Smoking / Q000009:adverse effects
chemical_list: D000863:Antacids; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D011899:Ranitidine; D008276:Magnesium Hydroxide