Dedifferentiated liposarcoma with features of rhabdomyosarcoma.
We describe a case of recurrent dedifferentiated retroperitoneal liposarcoma with light microscopy features of rhabdomyosarcoma, the first such reported case. The tumor contains a pleomorphic pattern consisting of plump fusiform cells, tadpole cells, malignant appearing lipoblasts, and other nondescript bizarre cells. Of particular interest is a number of tumor cells with plump, bizarre nuclei which contain cross-striations of skeletal muscle pattern. The literature on dedifferentiated liposarcoma is reviewed, and the significance of this case in terms of a current model of mesenchymal differentiation is discussed, with particular attention to the postulate of a common precursor for a variety of soft-tissue tumor histologies.
Salzano
R P
RP
Department of Surgery, Hartford Hospital.
Tomkiewicz
Z
Z
Africano
W A
WA
D002454:Cell Differentiation; D006801:Humans; D008080:Liposarcoma / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000648:ultrastructure