Effects of three dithiocarbamates on tissue distribution and excretion of cadmium in mice.
N-Benzyl-D-glucamine dithiocarbamate (BGD), N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), and N-p-carboxybenzyl-D-glucamine dithiocarbamate (CBGD) were compared for their relative efficacies in the distribution and excretion of cadmium in mice exposed to cadmium. Mice were injected intraperitoneally with 109CdCl2 (1 mg of Cd/kg and 2 microCi of 109Cd/one animal). Three days later, they were injected with chelating agents (400 mumol/kg) every other day for 2 weeks. After injections of BGD and HBGD, cadmium was excreted mainly in the feces through the bile, and the fecal excretion of cadmium by HBGD was significantly higher than that by BGD or CBGD. These chelating agents increased the urinary excretion of cadmium to a small extent. The hepatic cadmium content was decreased only after HBGD injection. Also, the injection of HBGD caused a much greater decrease in renal cadmium content than did BGD or CBGD. These chelating agents did not result in the redistribution of cadmium to the brain, testes, or heart. The growth of mice was only slightly retarded by injections of these chelating agents. The results of this study indicate that the injection of HBGD to mice pretreated with cadmium can remove cadmium from the body, mainly through fecal excretion, without redistribution of cadmium to other tissues such as the brain, testes, and heart, more effectively than BGD or CBGD.
Kojima
S
S
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Kawagoe
M
M
Kiyozumi
M
M
Shimada
H
H
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics* / Q000652:urine; D002614:Chelating Agents; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution / Q000187:drug effects
D002614:Chelating Agents; D013859:Thiocarbamates; D002104:Cadmium; C068198:N-4-hydroxymethylbenzylglucamine dithiocarbamate; C068199:N-4-carboxybenzylglucamine dithiocarbamate; D013012:Sorbitol; C048763:N-benzylglucamine dithiocarbamate