title: Chromosome locations of the MYB related genes, AMYB and BMYB.
abstract: The MYB related loci, AMYB and BMYB, were localized to specific human chromosome regions by Southern blot analysis of their segregation patterns in a panel of rodent-human hybrid DNAs using radiolabeled AMYB and BMYB probes. The AMYB locus was present in hybrids retaining the chromosome region 8cen----8q22 and was absent in hybrids which had lost this chromosome region. The presence of the BMYB locus in rodent-human hybrids correlated with, and only with, chromosome region Xq13. Chromosomal in situ hybridization refined the localization of AMYB to region 8q22-23 and confirmed the localization of BMYB to region Xq13. Chromosome region 8q22 is involved in recurrent translocations in malignant lymphoma and in acute myeloid leukemia (AML-M2); therefore AMYB is a candidate for involvement in such translocations. A region on Xq13 is also involved in chromosomal abnormalities in acute myeloid leukemia and myelodysplasias.
authors.affiliation: Raggio Italgene, Pomezia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Barletta
authors.forename: T
authors.initials: T
authors.lastname: Druck
authors.forename: S
authors.initials: S
authors.lastname: LaForgia
authors.forename: B
authors.initials: B
authors.lastname: Calabretta
authors.forename: H
authors.initials: H
authors.lastname: Drabkin
authors.forename: D
authors.initials: D
authors.lastname: Patterson
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
authors.forename: K
authors.initials: K
authors.lastname: Huebner
mesh_terms: D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020598:Proto-Oncogene Proteins c-myb; D011519:Proto-Oncogenes; D014960:X Chromosome
chemical_list: D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb