[Protective effect of hyperbaric hypoxygenation for paraquat poisoning in the rat].
The effect to paraquat in normobaric conditions and hyperbaric conditions with either a normal or low (10%) oxygen percentage was investigated in rats. Results showed that hyperbaric conditions increased the toxic effect of paraquat on the lung. By contrast, in hypoxic-hyperbaric conditions, the toxic effect of paraquat was decreased either clinically or macro-/microscopically, and lung injury was reduced.
Manieri
R
R
Service d'Anesthésiologie et Réanimation Hôpital S. Camillo, U.L.S. RM10, Rome, Italie.
Bronzi
R
R
Grilli
A
A
Loffredo
B
B
Data
P G
PG
Napolitano
L
L
Felaco
M
M
D000818:Animals; D001274:Atmospheric Pressure; D008168:Lung / Q000473:pathology; D009584:Nitrogen / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage*; D010269:Paraquat / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D051381:Rats; D011919:Rats, Inbred Strains
D009584:Nitrogen; D010269:Paraquat; D010100:Oxygen
Effet protecteur de l'hypoxygénation hyperbarique au cours de l'intoxication par le paraquat, chez le rat.