title: Uric acid synthesis by avian exocrine pancreas.
abstract: 1. Chicken pancreas has been shown to synthesize and secrete uric acid. Uric acid synthesis from xanthine in vitro by isolated pancreatic acinii is saturable and dependent on the activity of xanthine dehydrogenase. 2. Chicken pancreas is unable to synthesize uric acid de novo but the variety of substrates which support urate synthesis suggests that it occurs by the purine degradation pathway.
authors.affiliation: Biochemistry Department, Memorial University of Newfoundland, St John's, Canada.
authors.forename: G R
authors.initials: GR
authors.lastname: Herzberg
authors.forename: K
authors.initials: K
authors.lastname: Coady
authors.forename: B
authors.initials: B
authors.lastname: Maddigan
authors.forename: G
authors.initials: G
authors.lastname: MacCharles
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D002452:Cell Count; D002645:Chickens; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*; D019820:Xanthine; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
chemical_list: D011506:Proteins; D011687:Purines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D000493:Allopurinol; D014968:Xanthine Dehydrogenase