Prevention by nicardipine of dog basilar artery spasm caused by oxyhemoglobin in vivo and in vitro.
Intravenous infusions of nicardipine in a dose insufficient to lower blood pressure prevented the generation of the basilar artery spasm provoked by oxyhemoglobin (oxyHb) injected intracisternally in anesthetized dogs. The plasma concentration of nicardipine was comparable to that sufficient to suppress the oxyHb-induced contraction in isolated dog basilar arteries. Nicardipine appears to be similarly effective in antagonizing the vasoconstrictor action of oxyHb in vivo and in vitro.
Toda
N
N
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
Kawakami
M
M
Kodama
N
N
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D004285:Dogs; D066298:In Vitro Techniques; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000188:drug therapy*; D009529:Nicardipine / Q000494:pharmacology / Q000627:therapeutic use*; D010108:Oxyhemoglobins; D014661:Vasoconstriction / Q000187:drug effects
D010108:Oxyhemoglobins; D009529:Nicardipine