title: Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
abstract: The convulsant effect of different doses of picrotoxin was investigated in pentylenetetrazol-kindled and saline-treated mice. The percentage of convulsions was greater in the kindled mice, compared to controls.
authors.affiliation: Institute for Pharmacology and Toxicology, Medical Academy Magdeburg, GDR.
authors.forename: G
authors.initials: G
authors.lastname: Grecksch
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: H
authors.initials: H
authors.lastname: Matthies
mesh_terms: D000818:Animals; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010852:Picrotoxin / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010433:Pentylenetetrazole; D010852:Picrotoxin