Transplantation of autologous superior cervical ganglion into the brain of parkinsonian monkeys.
Autologous transplantation of the superior cervical ganglion (SCG) into the caudate nuclei of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian monkey was studied in regard to animal behavior and catecholamine (CA) metabolites in cerebrospinal fluid. Monkeys which had undergone autotransplantation of the SCG revealed an apparent improvement in motor activity. The homovanillic acid content in cerebrospinal fluid increased following the SCG transplantation and was correlated with an increase in motor activity. CA histofluorescence studies confirmed the long-term survival of the SCG graft in which many CA fibers and cells were observed. The present experiment indicates that dopamine released from the graft improved the symptoms of parkinsonism in the monkey.
Nakai
M
M
Department of Neurological Surgery, Wakayama Medical College, Japan.
Itakura
T
T
Komai
N
N
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002421:Caudate Nucleus / Q000601:surgery*; D004298:Dopamine / Q000502:physiology; D005728:Ganglia, Sympathetic / Q000502:physiology; D006085:Graft Survival / Q000502:physiology; D008251:Macaca; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009417:Nerve Tissue / Q000637:transplantation*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000601:surgery*; D013238:Stereotaxic Techniques
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine