title: [Synthesis of N,N-alkylene-bis-(substituted-phenol)glycine for removal of radio-actinides in rats].
abstract: The synthesis of 16 compounds of N, N-alkylene-bis (substituted phenol) glycine is reported. They showed good effects on the removal of redinuclide thorium-234 from rats, except compound 3 and compound 4. Two of them can remove more than 70% of injected thorium. The relationship between structure and effects of these compounds was discussed.
authors.affiliation: Shanghia Medical University, Institute of Radiation Medicine.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Sun
authors.forename: P E
authors.initials: PE
authors.lastname: Zhu
authors.forename: C
authors.initials: C
authors.lastname: Tang
authors.forename: A F
authors.initials: AF
authors.lastname: Chen
authors.forename: B Y
authors.initials: BY
authors.lastname: Shen
mesh_terms: D000818:Animals; D002614:Chelating Agents; D005243:Feces / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013910:Thorium / Q000378:metabolism / Q000652:urine
chemical_list: D002614:Chelating Agents; D010636:Phenols; D013910:Thorium; D005998:Glycine