[Physiological basis of goiter transformation of the thyroid gland and the pathogenesis of euthyroid goiter].
Endemic goiter disease develops as a result of iodine insufficiency in the environment, that induces advancing reproduction of thyrocytes realized by endomitosis. Eventually goiter-transformed gland ceases responding to the lack of iodine in the environment, that is due to the destruction of thyrocyte ++thyroreceptors. It should be taken into account that goiter disease depends upon the female sexual hormones.
Aleshin
B V
BV
D002455:Cell Division / Q000502:physiology; D005260:Female; D006043:Goiter, Endemic / Q000209:etiology*; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D007455:Iodine / Q000172:deficiency*; D008297:Male; D012737:Sex Factors; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology*
D007455:Iodine
Fiziologicheskie osnovy zobnoĭ transformatsii shchitovidnoĭ zhelezy i patogenez éutireoidnogo zoba.