title: Drug-induced fever: a clinical report and challenge test with calcium dobesilate.
abstract: A 54-year-old man was receiving calcium dobesilate for retinopathy and after 8 days he presented fever of more than 39 degrees C, generalized myalgia, chills and headache. Other causes of fever were ruled out. A challenge test was done with a single therapeutic oral dose of calcium dobesilate and fever appeared 20 h later and lasted 8 h. Our patient fulfils Young's stringent criteria for drug fever. To our knowledge drug-induced fever due to calcium dobesilate has not been reported previously.
authors.affiliation: Department of Allergy, Ramon y Cajal Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Puyana
authors.forename: J
authors.initials: J
authors.lastname: Fraj
authors.forename: F
authors.initials: F
authors.lastname: De La Hoz
authors.forename: I
authors.initials: I
authors.lastname: Davila
authors.forename: C
authors.initials: C
authors.lastname: Vergara
authors.forename: J
authors.initials: J
authors.lastname: Cuesta
mesh_terms: D002123:Calcium Dobesilate / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002123:Calcium Dobesilate