Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson's disease.
The main objective of this study was to determine whether the activation of dopaminergic pathways through adrenal-caudate transplantation stimulates the production of the dopamine cyclic metabolite salsolinol in CSF of patients with Parkinson's disease. Salsolinol sulfate in CSF samples was assayed by radioenzymatic technique. The outcome of this study revealed that the replacement of degenerative nigrostriatal neurons with new dopamine-producing cells by adrenal brain transplants resulted in significant increase in CSF concentration of salsolinol sulfate as compared to preoperative levels.
Faraj
B A
BA
Department of Radiology (Division of Nuclear Medicine), Emory University School of Medicine, Atlanta, Georgia.
Camp
V M
VM
Watts
R L
RL
D000311:Adrenal Glands / Q000637:transplantation*; D002421:Caudate Nucleus / Q000502:physiology*; D006801:Humans; D007546:Isoquinolines / Q000134:cerebrospinal fluid*; D009417:Nerve Tissue / Q000637:transplantation*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000628:therapy; D014184:Transplantation, Homologous
D007546:Isoquinolines; C036617:salsolinol