title: Electrical impedance, rCBF, survival and histology in Mongolian gerbils with forebrain ischaemia.
abstract: Survival, quantitative morphology of the hippocampus, cerebral tissue impedance and regional cerebral blood flow (rCBF) were studied in the Mongolian gerbil after 15 minutes of bilateral common carotid occlusion. A subgroup of animals was placed in cages with free access to running-wheels for two weeks preceding ischaemia to measure voluntary locomotor activity. Survival was enhanced in the running-wheel subgroup, with 90% of the animals still alive after 14 days as compared to 48% of the non-running group. Neuronal loss was found in all animals in the hippocampus (CA1, CA2, CA3 and CA4), and was most pronounced in the CA1 sector. In the running-wheel group, however, neuronal loss was significantly lower in sectors CA2, CA3 and CA4. The increases of cerebral impedance, which indicate ischaemic cell swelling, reached 190% in both groups during ischaemia. During postischaemic recirculation, however, impedance normalized more rapidly in the running-wheel group, indicating earlier resolution of ischaemic cell swelling. In wheel-running gerbils, postischaemic hyperperfusion evolved earlier and was more pronounced as compared to non-runners. No differences in systemic blood pressure were observed during cerebral ischaemia or thereafter.
authors.affiliation: Institute for Surgical Research, Klinikum Grosshadern, Munich, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Stummer
authors.forename: K
authors.initials: K
authors.lastname: Weber
authors.forename: L
authors.initials: L
authors.lastname: Schürer
authors.forename: A
authors.initials: A
authors.lastname: Baethmann
authors.forename: O
authors.initials: O
authors.lastname: Kempski
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004594:Electrophysiology; D005849:Gerbillinae; D008297:Male; D009043:Motor Activity / Q000502:physiology; D016019:Survival Analysis