Prevention of selenite cataract by vitamin C.
Studies have been conducted to determine the efficacy of vitamin C in the prevention of cataracts induced by selenite. Administration of the latter to rat pups results in the development of advanced cataracts within 5 days. Treatment with ascorbate had a significant preventive effect. The observations indicate that selenite cataract is due to an oxidative stress to the lens. In addition, the findings are in conformity with our view that ascorbate functions as an anticataractogenic substance.
Devamanoharan
P S
PS
Department of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201.
Henein
M
M
Morris
S
S
Ramachandran
S
S
Richards
R D
RD
Varma
S D
SD
D015104:3,4-Methylenedioxyamphetamine / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism / Q000627:therapeutic use*; D002386:Cataract / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D003459:Crystallins / Q000032:analysis; D005978:Glutathione / Q000032:analysis; D007908:Lens, Crystalline / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium
D003459:Crystallins; D015104:3,4-Methylenedioxyamphetamine; D000255:Adenosine Triphosphate; D020887:Selenious Acid; D005978:Glutathione; D012643:Selenium; D001205:Ascorbic Acid