title: Excessive excretion of 5-oxoproline and decreased levels of blood glutathione in type II diabetes mellitus.
abstract: Levels of blood glutathione (GSH) were measured in 26 type II diabetes mellitus patients compared to 36 controls. Total blood GSH did not differ significantly between the two groups (mean +/- s.d., 8.0 +/- 1.5 vs. 7.7 +/- 1.3 mmol/g Hb, respectively); however reduced GSH was lowered in diabetes mellitus (5.0 +/- 1.0 vs. 5.8 +/- 1.0 mmol/gHb; P = 0.01), whereas oxidized GSH was increased (0.4 +/- 0.2 vs. 0.2 +/- 0.1 mmol/gHb; P = 0.001). Urinary excretion of 5-oxoproline was excessive in the diabetic patients (14.5 +/- 9.9 vs. 3.8 +/- 1.4 mmol/24 h; P = 0.004), and was positively correlated with levels of glycosylated haemoglobin (r = 0.69; P less than 0.01).
authors.affiliation: Tropical Metabolism Research Unit, University of the West Indies, Kingston, Jamaica.
authors.forename: T E
authors.initials: TE
authors.lastname: Forrester
authors.forename: V
authors.initials: V
authors.lastname: Badaloo
authors.forename: F I
authors.initials: FI
authors.lastname: Bennett
authors.forename: A A
authors.initials: AA
authors.lastname: Jackson
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011761:Pyrrolidonecarboxylic Acid / Q000652:urine*; D012044:Regression Analysis
chemical_list: D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid