[Platelet hypoactivity in hypocholesterolemia].
A 6-year-old girl with severe malabsorption resulting from pancreatic insufficiency, and with hypocholesterolemia is described. 57% of her plasma cholesterol was found in high density lipoprotein (HDL), 95 mg/dl, while only 25 mg/dl was in the low density lipoprotein (LDL) fraction. Platelet aggregation in platelet-rich plasma, in response to both collagen and ADP, were substantially reduced (by 54 and 33%, respectively) in comparison with normal controls. However, after removal of plasma and washing the isolated platelets, they were not hypoactive. These results suggest that the plasma environment affects platelet activity, and confirms our in vitro results on the enhancing and inhibiting effects of LDL and HDL, respectively, on platelet activity.
Aviram
M
M
Lipid Research Unit, Rambam Medical Center, Haifa.
Davidai
G
G
Brook
G J
GJ
D002648:Child; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D010188:Exocrine Pancreatic Insufficiency / Q000097:blood*; D005260:Female; D006801:Humans; D010974:Platelet Aggregation
D008076:Cholesterol, HDL; D002784:Cholesterol