[The effect of calcium channel blockers on myoclonus induced by DDT].
Behaviour syndrome induced by P, p'-DDT in rats constitutes an experimental pattern of myoclonia whose neurochemical basis is not yet clear. In this paper, effects of some calcium canal antagonists (CCA) have been studied. Nicardipine, verapamil and diltiazem significantly reduce myoclonia intensity, whereas flunarizine and cinarizine (the two diphenylalkylamines) enhance it. Mechanisms involved are unknown and it is not possible to foresee the clinical usefulness of CCA in these changes.
Rabasa
M
M
Departamento de Investigación, Centro Ramón y Cajal, Madrid.
Tabernero
C
C
Pardo
B
B
García de Yébenes
J
J
D000818:Animals; D000927:Anticonvulsants; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003634:DDT; D004305:Dose-Response Relationship, Drug; D005260:Female; D009207:Myoclonus / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D003634:DDT
Efecto de los antagonistas de los canales de calcio sobre las mioclonías inducidas por DDT.