[Antiglaucoma ophthalmic agents with prolonged action with based on macromolecular excipients. 3. Optimized drop preparation on a polyacrylate base].
In contrast to the standardized product Carbopol 940, polyacrylic acid-Fluka (PAS-F, a copolymerized product of acrylic and methacrylic acid) can form liquid preparations, which have weak acid pH values from 5.3 to 6.5. Such pH-values are euhydric pH-values of many medical substances. Different PAS-F-preparations were developed and their physical-chemical parameters were characterized. 3.5% PAS-F and pilocarpine or carbachol containing preparations have suitable viscosities from 18 to 72mPa.s. According to in vitro tests, these preparations showed a significantly prolonged release of the drugs compared to the aqueous solutions. In human tests, the physiological compatibility of PAS-F-preparation was proved and the drug action was prolonged as well as the drug intensity was increased compared to the aqueous solutions of drugs.
Keipert
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S
Sektion Chemie, Humboldt-Universität zu Berlin.
Siebenbrodt
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D000180:Acrylic Resins / Q000737:chemistry*; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D015877:Miosis; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D009994:Osmolar Concentration; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D009883:Ophthalmic Solutions; D010862:Pilocarpine; C006903:carbopol 940; D002217:Carbachol
Antiglaukomatosahaltige Ophthalmika mit prolongierter Wirkung auf Basis makromolekularer Hilfsstoffe. Teil 3: Optimierte, tropfbare Rezepturen auf Polyacrylatbasis.