Contrasting tissue factors predict heterogeneous striatal dopamine neurotoxicity after MPTP or methamphetamine treatment.
Treatment of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or (+)-methamphetamine (METH) results in regionally heterogeneous patterns of dopaminergic depletion. The magnitude of the MPTP-induced dopamine (DA) depletion corresponds directly to the density of [3H]mazindol binding to DA transport sites, but not the DA concentration, in intact mouse striatal regions. In contrast, the extent of METH-induced DA depletion corresponds to the intact dopamine concentration, not the [3H]mazindol binding, in the same striatal regions. The findings provide a rationale for testing different hypotheses regarding the neurobiological substrates of mesostriatal injury in idiopathic Parkinson's disease (PD).
Marshall
J F
JF
Department of Psychobiology, University of California Irvine 92717.
Navarrete
R J
RJ
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D004298:Dopamine / Q000378:metabolism*; D020267:MPTP Poisoning; D008297:Male; D008454:Mazindol / Q000378:metabolism; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D009498:Neurotoxins; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism
D009498:Neurotoxins; D011954:Receptors, Dopamine; D008694:Methamphetamine; D008454:Mazindol; D004298:Dopamine