[Cerebral aminopeptidase activity: effect of the administration of imipramine].
Imipramine is widely accepted as an effective antidepressant treatment. In this paper, changes in Lys- and Leu-aminopeptidase activities in several rat brain regions after imipramine treatment are described. Decreases of Lys-aminopeptidase activity in the olphactory bulbus, cerebellum, hypothalamus and pituitary gland were observed. In the same way, there were a decreases in Leu-aminopeptidase activity in the parietal and occipital cortices, cerebellum thalamus, hypothalamus and pituitary gland. It is suggested that these enzyme activities play a part in the imipramine action mechanism, possibly by regulating the activity of several neuroactive peptides.
de Gandarias
J M
JM
Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao.
Irazusta
J
J
Echecarría
E
E
Múgica
J
J
Casis
L
L
D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D007099:Imipramine / Q000494:pharmacology*; D007931:Leucyl Aminopeptidase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D007099:Imipramine
Actividad aminopeptidásica cerebral: efecto de la administración de imipramina.