title: Effects of moderate dietary phosphorus restriction on intestinal absorption and external balances of phosphorus and calcium in growing female rabbits.
abstract: The effects of moderate dietary P restriction on intestinal net fluxes and external balances of P and Ca were studied in growing female albino rabbits that were fed a P-deficient diet for 10 consecutive days while they were housed in metabolism cages. Intestinal P secretion occurred during the first 24 h of P restriction and thereafter changed to absorption. During recovery, when the rabbits were consuming a normal diet, P absorption was significantly greater than either prerestriction control values or than in a separate group of time control rabbits. Phosphorus balance was negative during the 1st day of P restriction but thereafter became positive. This pattern occurred because intestinal P secretion changed to absorption and because urinary losses of P were negligible. Intestinal Ca absorption increased within 24 h of P restriction, reached maximal values by 4 days, and remained elevated for each of the remaining 6 days that dietary P was low. It also was elevated compared to P-sufficient time controls for 8 days after replenishment of dietary P. Despite increased intestinal absorption, Ca balance was significantly reduced during P restriction because of substantial hypercalciuria. Thus, selective dietary P restriction reduced the positive balances of both P and Ca that are characteristic of growth. We conclude that in growing rabbits moderate dietary P restriction induces both intestinal and renal adaptations that conserve this mineral; concomitantly, positive Ca balance is reduced. With dietary P replenishment, adaptations persist to restore the positive mineral balances that were lost because of dietary P restriction during growth.
authors.affiliation: Division of Renal Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill.
authors.forename: J E
authors.initials: JE
authors.lastname: Bourdeau
authors.forename: D M
authors.initials: DM
authors.lastname: DePalo
authors.forename: D R
authors.initials: DR
authors.lastname: Barr
authors.forename: J
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005243:Feces; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects / Q000254:growth & development; D007668:Kidney / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D016226:Phosphorus, Dietary; D010758:Phosphorus; D002118:Calcium