Transfer of cyclosporine in the perfused human placenta.
Transfer of cyclosporine A (CsA) in the human placenta has been studied in vitro using a dual perfusion technique of isolated placental lobules. Antipyrine was used as a reference marker for comparison. Our studies showed a negligible transfer of CsA from the maternal to the fetal circulation, representing less than 5% of the maternal drug load. These results are in agreement with that reported earlier in an in vivo study in a pregnant woman. We conclude that the low placental transfer of CsA is attributable mainly to the drug's relatively high molecular weight.
Nandakumaran
M
M
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Kuwait, Safat.
Eldeen
A S
AS
D000983:Antipyrine / Q000493:pharmacokinetics; D003524:Cyclosporins / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D008970:Molecular Weight; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D003524:Cyclosporins; D000983:Antipyrine