Studies of the release rate and bioavailability of antineoplaston A10 capsule.
The effect of Tween-80 on the release rate of antineoplaston A10 capsule in vitro was measured. When 0.1% Tween-80 was added to A10 capsule, the cumulative release rate of A10 was doubled in artificial gastric juice and tripled in artificial enteric juice within 2 h. The bioavailability of A10 capsules was determined with tritium-labelled A10 in rabbits. The results showed that the bioavailability of A10 capsule containing 0.1% Tween-80 increased 44.05%. The highest concentration of A10 in the blood was increased 35%. The time to reach peak was reduced 1 h.
Wang
H
H
Shandong Medical University, Department of Pharmacy, Jinan, China.
Xu
W
W
Yuan
Y
Y
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D044482:Benzeneacetamides; D001682:Biological Availability; D002214:Capsules; D007275:Injections, Intravenous; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010881:Piperidones; D011817:Rabbits
D000970:Antineoplastic Agents; D044482:Benzeneacetamides; D002214:Capsules; D010880:Piperidines; D010881:Piperidones; C052091:antineoplaston A10