title: Effect of L-cysteine on distribution volume of 1-(tetrahydro-2-furanyl)-5-fluorouracil.
abstract: Higher plasma concentrations of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) were obtained after administration of FT (100 mg/kg, i.v.) combined with L-cysteine (CySH, 500 mg/kg, p.o.). The volume of distribution (Vd) and body fluid volumes significantly decreased. These results suggest that the increase of the plasma concentrations of FT can be attributed to the decrease of the Vd of FT, which is considered to be based on the decrease of body fluid volumes by the combined administration of CySH.
authors.affiliation: Central Research Laboratory, SS Pharmaceutical Co., Ltd., Narita, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawabata
authors.forename: K
authors.initials: K
authors.lastname: Yano
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000818:Animals; D003545:Cysteine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005110:Extracellular Space; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D005641:Tegafur / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
chemical_list: D005641:Tegafur; D003545:Cysteine