[Leukocyte phagocytic activity in gerbils with experimental sporotrichosis treated with potassium iodide].
One effective treatment against sporotrichosis is the oral administration of potassium iodide (KI). It is not known how it works, and also it is not known if this substance has some effect on the microbicidal activity of polymorphonuclear neutrophils (PMN) and macrophages. In this work the phagocytic activity of gerbils treated with KI was studied. Gerbils cured within 62 days of treatment with KI, their PMN and macrophages showed an increased ability for reducing nitroblue-tetrazolium (NBT); myeloperoxidase activity was decreased in PMN. These results were the expected in any chronic infection and demonstrates that KI effectiveness on the experimental sporotrichosis works by an independent mechanism of phagocytosis.
Ramos Zepeda
R
R
División de Patología Experimental, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco.
Ramos Zepeda
R
R
Ramos Damian
M E
ME
González Rico
B M
BM
González Mendoza
A
A
D000818:Animals; D005849:Gerbillinae; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000187:drug effects*; D011193:Potassium Iodide / Q000627:therapeutic use*; D013174:Sporotrichosis / Q000188:drug therapy*
D011193:Potassium Iodide
Estudio de la actividad fagocítica de los leucocitos de gerbiles con esporotricosis experimental tratados con ioduro de potasio.