[A modification of the toxic effects of platinum complexes with antocyans].
The toxic and antitumor properties of biocysplantinum (cis-diaminodichlo-platinum) as well as a new platinum complex with acetic acid after their single and combined usage with antocyanes were studied on healthy mice and mice with transplanted ascitic tumour of Ehrlich. There was a reduction in total toxicity of biocysplatinum after simultaneous administration with antocyanes (300 mg/kg per os). Protective effect of antocyanes was observed on leukocytopoiesis. Preservation of antitumor activity of platinum complexes was found in the tumour of Ehrlich. The obtained data indicate possibilities for usage of antocyanes as chemioprotectors during therapy with drugs, containing platinum.
Karaivanova
M
M
Drenska
D
D
Ovcharov
R
R
D000085:Acetates / Q000627:therapeutic use / Q000633:toxicity*; D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use / Q000633:toxicity*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D007928:Lethal Dose 50; D051379:Mice; D009368:Neoplasm Transplantation
D000085:Acetates; D000872:Anthocyanins; D002945:Cisplatin
Modifitsirane na toksichnite efekti na platinovi kompleksi s antotsiani.