Increased coronary tone in exertional angina: the beneficial effects of calcium antagonists.
Coronary vasoconstriction may play a relevant role in the pathogenesis of exercise-induced myocardial ischemia, not only in patients with Prinzmetal's angina, but also in patients with chronic stable angina. In these patients the use of calcium antagonists, namely, dihydropyridine derivatives, may be beneficial. Hyperventilation is a simple and sensitive test to discriminate patients with effort angina who will improve their exercise capacity after administration of these drugs.
Specchia
G
G
Divisione di Cardiologia, Policlinico San Matteo, IRCCS, Pavia, Italy.
Ardissino
D
D
Ghio
S
S
Barberis
P
P
Colombo
M L
ML
De Servi
S
S
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D015444:Exercise / Q000502:physiology; D006321:Heart / Q000502:physiology; D006801:Humans; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*
D002121:Calcium Channel Blockers