Clofibrate-induced myopathy in a patient with primary hypothyroidism.
Acute muscle pain with stiffness developed in a patient with latent hypothyroidism after administration of clofibrate. Serum creatine kinase (CK), aspartate aminotransferase, and lactate dehydrogenase were markedly elevated, but returned to normal one and a half months after the discontinuation of clofibrate. Clofibrate challenge (750 mg/day) for three days caused muscle pain and an elevation in serum CK. Hypothyroidism may be a predisposing factor in the development of clofibrate-induced myopathy.
Hattori
N
N
Department of Endocrinology, Kobe General Hospital, Japan.
Shimatsu
A
A
Murabe
H
H
Nishimura
M
M
Nakamura
H
H
Imura
H
H
D000328:Adult; D002994:Clofibrate / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D009135:Muscular Diseases / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D010146:Pain / Q000209:etiology; D013966:Thyroiditis / Q000150:complications
D003402:Creatine Kinase; D002994:Clofibrate