Intraocular tolerance to silicone oils of different specific gravities. An experimental study.
Different methylphenylsilicone (MPS) and fluorosilicone (FS) oils having a higher specific gravity than water were investigated as vitreous replacements. Their intraocular tolerance in vitrectomized aphakic rabbit eyes was evaluated for periods of up to 4 months and compared to that of regular polydimethylsilicone oil (PDMS). Weakly fluorinated FS and weakly phenylated MPS showed a presumably toxic effect on the retina. As compared to highly fluorinated FS, highly phenylated MPS showed better intraocular tolerance; however, inflammatory reaction was slightly more extensive than in eyes filled with PDMS.
Eckardt
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C
Department of Ophthalmology, Christian-Albrechts-Universität, Kiel, FRG.
Schmidt
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D
Czank
M
M
D000818:Animals; D015715:Corneal Edema / Q000139:chemically induced / Q000473:pathology; D004129:Dimethylpolysiloxanes / Q000633:toxicity; D005500:Follow-Up Studies; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D007498:Iris / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012163:Retinal Detachment / Q000139:chemically induced / Q000473:pathology; D012827:Silicone Oils / Q000633:toxicity*; D012828:Silicones / Q000633:toxicity; D012833:Siloxanes / Q000633:toxicity; D013046:Specific Gravity; D014821:Vitrectomy
D004129:Dimethylpolysiloxanes; D012827:Silicone Oils; D012828:Silicones; D012833:Siloxanes; C054077:fluorosilicone oil; C014763:polymethylphenylsiloxane; C013830:baysilon