Influence of ethanol and acetaldehyde on the activity and release of cathepsin A from liver lysosomes.
Ethanol and acetaldehyde inhibited the activity of cathepsin A. In vitro ethanol did not release cathepsin A from liver lysosomes whereas acetaldehyde of high concentration did. Intoxication of rats with ethanol and acetaldehyde evoked a transient increase of free and bound cathepsin A.
Ostrowska
H
H
Department of Instrumental Analysis, Medical Academy, Białystok, Poland.
Kamiński
J
J
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D002268:Carboxypeptidases / Q000378:metabolism*; D043402:Cathepsin A; D002403:Cathepsins / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D051381:Rats
D000431:Ethanol; D002268:Carboxypeptidases; D002403:Cathepsins; D043402:Cathepsin A; D000079:Acetaldehyde