Abnormal accumulation of vanadium in patients on chronic hemodialysis therapy.
Vanadium (V) has been reported to inhibit a number of enzyme activities such as those of Na(+)-K(+)-ATPase. The main excretory pathway of this element is via the kidney. These facts led us to study the V distribution in uremic patients. As a result, hemodialysis patients at our dialysis center exhibited extremely high levels of serum V (23.9 +/- 11.3 ng/ml, n = 43) as compared with healthy adults. Nondialysis patients did not show increased serum V concentrations. The V contents were significantly elevated in the skin and in the aortae of hemodialysis patients. It was found that the tap water from Kanagawa prefecture, Japan, had the highest V concentrations among the 21 cities in Japan and the US. In conclusion, oral ingestion of V-contaminated water has likely caused an accumulation of the metal in patients with end-stage renal failure.
Tsukamoto
Y
Y
Department of Medicine, Kitasato University of Medicine, Sagamihara, Japan.
Saka
S
S
Kumano
K
K
Iwanami
S
S
Ishida
O
O
Marumo
F
F
D000328:Adult; D000368:Aged; D001011:Aorta / Q000378:metabolism; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000378:metabolism; D014481:United States; D014511:Uremia / Q000378:metabolism* / Q000628:therapy; D014639:Vanadium / Q000032:analysis / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis
D014874:Water Pollutants, Chemical; D014639:Vanadium