Influence of desglycinamide-(arg8) vasopressin on memory in healthy subjects.
In 12 healthy student volunteers the influence on memory, attention and mood of a single dose of 2 mg of the vasopressin analog, desglycinamide-(arg8) vasopressin (DGAVP), given by the nasal route was investigated. On day 1 all subjects received placebo (single-blind), 1 week later they were given either DGAVP or placebo (double-blind). Memory effects were measured with the Buschke restrictive reminding method. DGAVP significantly improved storage processes, with retrieval processes less affected. Attention and mood processes were not influenced. It is suggested that DGAVP has an influence on memory processes.
Bruins
J
J
Department of Psychology, University of Amsterdam, The Netherlands.
Kumar
A
A
Schneider-Helmert
D
D
D000328:Adult; D000339:Affect / Q000187:drug effects; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001288:Attention / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D009483:Neuropsychological Tests; D012016:Reference Values
D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-