CNS and PNS effects of nimodipine.
Calcium ions play a decisive role in a large number of processes dealing with development, regeneration after damage, and aging of elements of the nervous system. Nimodipine, a member of the 1,4-dihydropyridine chess of calcium-channel blockers, has proved to influence the calcium metabolism of neurons. This review focuses on the results of recent studies on the role of nimodipine in both the central and peripheral nervous system, during or after events that threaten the integrity or function of the nervous system.
Bär
P R
PR
Department of Neurology, University of Utrecht, The Netherlands.
Traber
J
J
Schuurman
T
T
Gispen
W H
WH
D000375:Aging / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002118:Calcium / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009553:Nimodipine / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000187:drug effects*
D009553:Nimodipine; D002118:Calcium