title: Structure-activity relationship studies of CNS agents. Part 1: The Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines.
abstract: It has been found that 3-alkoxycarbonyl-beta-carbolines are almost non-toxic and showed a sedative effect. The quantitative relationship between the structure of some 1,2,3,4-tetrahydro-beta-carbolines and their acute toxicity and sedative effect was found using the Free-Wilson approach.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: J L
authors.initials: JL
authors.lastname: Mokrosz
authors.forename: M
authors.initials: M
authors.lastname: Dukat
authors.forename: S
authors.initials: S
authors.lastname: Misztal
authors.forename: E
authors.initials: E
authors.lastname: Chojnacka-Wójcik
authors.forename: E
authors.initials: E
authors.lastname: Tatarczyńska
mesh_terms: D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001831:Body Temperature / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D002243:Carbolines; D006993:Hypnotics and Sedatives