Quantitating the production of biological reactive intermediates in target tissues: example, dichloromethane.
Development of quantitative mathematical models for the production of BRIs in target tissues can provide valuable insights into the mechanisms of toxicity for specific chemicals. Furthermore, use of mechanistic information and mathematical modeling in the hazard evaluation process should significantly reduce the uncertainty inherent in extrapolating the results of animal toxicity tests to man.
Reitz
R H
RH
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008752:Methylene Chloride / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced*
D008752:Methylene Chloride; D006899:Mixed Function Oxygenases; D005978:Glutathione