Effect of nifedipine and anticonvulsants on kainic acid-induced seizures in mice.
The calcium-channel inhibitor nifedipine and several anticonvulsant drugs were evaluated for effects on seizures induced by intracerebroventricular injection of 0.14 microgram of kainic acid. These seizures were markedly exacerbated by valproic acid and moderately inhibited by diazepam. Nifedipine decreased the duration of each individual seizure episode, but did not block the development of seizures. It is concluded that nifedipine prevents the maintenance or propagation of kainate-induced seizures.
Braun
D E
DE
Department of Neurosurgery, Naval Hospital Bethesda, MD 20814.
Freed
W J
WJ
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D051379:Mice; D009543:Nifedipine / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D009543:Nifedipine; D007608:Kainic Acid