[Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats].
The study was made on the reserpine model of behavioural depression in cats. The morphofunctional state of peripheral adrenergic nerves in control experiments and under action of antidepressants (befol and nialamid) was studied by fluorescent microscopic method. One definite correlation was shown between the state of somatovegetative changes and the level of neuromediator activity of the adrenergic structures. It was established that the used antidepressants (more expressive by befol) have protective effect in depressive conditions.
Khaĭsman
E B
EB
Kushnarev
V V
VV
D000320:Adrenergic Fibers / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D002415:Cats; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009526:Nialamide / Q000494:pharmacology*; D012110:Reserpine / Q000008:administration & dosage / Q000009:adverse effects
D000928:Antidepressive Agents; D001549:Benzamides; D009025:Morpholines; C059049:befol; D012110:Reserpine; D009526:Nialamide
Rol' perifericheskogo adrenergicheskogo zvena v razvitii éffekta antidepressantov na éksperimental'noĭ modeli depressii povedeniia u koshek.