Pheno- and genotypic characteristics of human non-Hodgkin lymphoma xenografts.
The three human non-Hodgkin lymphoma xenografts with different morphological appearance (lymphoblastic, centroblastic, centrocytic) had many common pheno- and genotypic features positivity of B-cell markers, 14q+ chromosomal abnormality, etc.). Furthermore, two lines (HT 58 and 130) expressed lambda light chain monoclonally. The third line (HT 117) showed bigenotypic rearrangement of light genes. A set of new anti-proteoglycan markers, especially anti-chondroitin sulfate mAbs made possible to individualize the xenografts.
Kopper
L
L
Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Bánkfalvi
A
A
Mihalik
R
R
Timár
J
J
Glant
T
T
D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D002883:Chromosomes, Human, Pair 14; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D009368:Neoplasm Transplantation; D010641:Phenotype; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D004273:DNA, Neoplasm