Acute toxoplasma myositis: an immunohistochemical and ultrastructural study.
The occurrence is reported of acute myositis in a man with meningoencephalitis due to toxoplasmosis. The ultrastructure and immunohistochemistry of a muscle biopsy of the patient were investigated. Toxoplasma organisms were not found in the muscle biopsy. The perivascular inflammatory cells in the muscle were mainly CD4+ T cells and the inflammatory cells in and around the muscle fibres were chiefly macrophages. Expression of major histocompatibility complex class I and II antigens was observed in the infiltrating cells and endothelial cells of the blood vessels. A small proportion of the infiltrating cells expressed interferon-gamma. A possible role of the immune mechanism in the evolution of myositis is discussed.
Matsubara
S
S
Department of Neurology, Kanazawa University School of Medicine, Ishikawa, Japan.
Takamori
M
M
Adachi
H
H
Kida
H
H
D000208:Acute Disease; D000328:Adult; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009220:Myositis / Q000209:etiology / Q000473:pathology*; D014123:Toxoplasmosis / Q000150:complications*