Effects of adenosine analogues on guinea-pig endometrial secretion.
The effect of adenosine analogues on guinea-pig endometrial secretion was studied in vitro at defined days of the estrous cycle. The adenosine analogues, 5'-N-ethylcarboxamideadenosine (NECA) and (N6-[(R)-1-methyl-2-phenylethyl]-adenosine (R-PIA), induced endometrial secretion at ovulation time (cycle days 16-1) and at implantation time (cycle days 6-7). The secretory response to NECA was antagonized by 8-p-sulfophenyltheophylline. Scopolamine had no effect on secretion induced by the adenosine analogues. Endometrial secretion induced by field stimulation was inhibited by NECA but not by R-PIA at ovulation time. At implantation time, both NECA and R-PIA reversed the response to field stimulation to values below the basal resting level. The latter effect was antagonized by phentolamine. These findings suggest that adenosine analogues can induce guinea-pig endometrial secretion by action at stimulatory adenosine receptors, and concomitantly inhibit secretomotor neurotransmission.
Hammarström
M
M
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
Wiklund
N P
NP
Samuelson
U E
UE
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D003956:Dialysis; D004558:Electric Stimulation; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004971:Estrus / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D010060:Ovulation / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology
C047235:N-(1-methyl-2-phenylethyl)adenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine; D010646:Phentolamine