Adrenal medullary transplantation for Parkinson's disease.
Autotransplantation of adrenal medullary tissue to the right caudate nucleus was performed in 8 patients (6 men and 2 women) with Parkinson's disease demonstrating mainly rigidity and bradykinesia. Their mean age was 52 years. The mean duration of Parkinson's disease was 7 years. Left adrenalectomy and open craniotomy were done to implant medullary tissue into the right caudate nucleus. The 6-month clinical findings were evaluated. 5 cases showed improvement, 2 cases remained unchanged and 1 was worse. There was no operative mortality, but 1 patient developed right frontal infarction postoperatively and 2 patients demonstrated subdural hygroma.
Choi
C R
CR
Department of Neurosurgery, Catholic University Medical College, Seoul, Korea.
Lee
J S
JS
Sung
K W
KW
Song
J U
JU
D000313:Adrenal Medulla / Q000637:transplantation*; D002421:Caudate Nucleus / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis*; D013238:Stereotaxic Techniques