title: Application of volume-selected, two-dimensional multiple-quantum editing in vivo to observe cerebral metabolites.
abstract: The volume selection technique SPACE has been combined with a two-dimensional multiple-quantum editing sequence to uniquely detect certain J-coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple-quantum generation and signal loss due to T2 relaxation. Without due regard to T2 relaxation little signal is observed.
authors.affiliation: Department of Chemistry, University of Queensland, St. Lucia, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Crozier
authors.forename: I M
authors.initials: IM
authors.lastname: Brereton
authors.forename: S E
authors.initials: SE
authors.lastname: Rose
authors.forename: J
authors.initials: J
authors.lastname: Field
authors.forename: G F
authors.initials: GF
authors.lastname: Shannon
authors.forename: D M
authors.initials: DM
authors.lastname: Doddrell
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051381:Rats