In vivo and in vitro evidence for in situ activation and selective covalent binding of acetaminophen (APAP) in mouse kidney.
Emeigh Hart
S G
SG
Toxicology Program, Department of Pathobiology, University of Connecticut, Storrs.
Birge
R B
RB
Cartun
R W
RW
Tyson
C A
CA
Dabbs
J E
JE
Nishanian
E V
EV
Wyand
D S
DS
Khairallah
E A
EA
Cohen
S D
SD
D000082:Acetaminophen / Q000378:metabolism* / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System