Effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms.
The effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms was investigated. Latamoxef sodium (LMOX, 25 mg/kg/d, intravenously) and cephalexin (CEX, 16.7 mg/kg/d, orally) were administered for 1 or 3 d. The blood concentration of salicyluric acid and salicylic acid following oral, intracecal and rectal administration of salicyluric acid was determined. By the pretreatment with LMOX for 1 or 3 d, the blood concentration of salicylic acid following oral administration of salicyluric acid was slightly decreased. In rabbits pretreated with CEX for 3 d, the blood concentration of salicylic acid was detected at low concentration. By the pretreatment with LMOX and CEX, however, the decrease in the blood concentration of salicylic acid following rectal administration of salicyluric acid was not observed. Although the examination of population of intestinal microorganisms induced by the pretreatment with antibiotics was not performed, the metabolic activity of intestinal microorganisms may be changed.
Nakamura
J
J
Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Haraguchi
Y
Y
Asai
K
K
Sasaki
H
H
Shibasaki
J
J
D000284:Administration, Oral; D000285:Administration, Rectal; D000818:Animals; D002432:Cecum; D002506:Cephalexin / Q000494:pharmacology*; D006626:Hippurates / Q000378:metabolism*; D006868:Hydrolysis; D007267:Injections; D007422:Intestines / Q000382:microbiology*; D008297:Male; D009070:Moxalactam / Q000494:pharmacology*; D011817:Rabbits
D006626:Hippurates; C000693:salicylurate; D002506:Cephalexin; D009070:Moxalactam