title: Design of enzyme inhibitors using iterative protein crystallographic analysis.
authors.affiliation: Agouron Pharmaceuticals, Inc., La Jolla, California 92037.
authors.forename: K
authors.initials: K
authors.lastname: Appelt
authors.forename: R J
authors.initials: RJ
authors.lastname: Bacquet
authors.forename: C A
authors.initials: CA
authors.lastname: Bartlett
authors.forename: C L
authors.initials: CL
authors.lastname: Booth
authors.forename: S T
authors.initials: ST
authors.lastname: Freer
authors.forename: M A
authors.initials: MA
authors.lastname: Fuhry
authors.forename: M R
authors.initials: MR
authors.lastname: Gehring
authors.forename: S M
authors.initials: SM
authors.lastname: Herrmann
authors.forename: E F
authors.initials: EF
authors.lastname: Howland
authors.forename: C A
authors.initials: CA
authors.lastname: Janson
mesh_terms: D003461:Crystallography; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D013940:Thymidylate Synthase