[The hematotoxic and nephrotoxic actions of dispirotripiperazine derivatives in a chronic experiment].
The effects of dispirotripiperazine derivatives spirobromin and prospidin on the parameters of the peripheral blood and behavioral reactions in a chronic 12-month experiment were studied. The experiment was performed on noninbred rats of both sexes. The maximal tolerated doses of the drugs were administered by two routes (intragastrically or intraperitoneally). Hemoglobin, erythrocytes, leukocytes, platelets, reticulocytes, eosinophils were determined in the blood. The behavioral reactions were registered by the methods of the "open field" and the "open area". Under the conditions of the chronic experiment spirobromin and prospidin were shown to exert no significant effect on the parameters of the peripheral blood except a decrease in the amount of erythrocytes. It was noted that spirobromin exerted the most pronounced toxic action on erythrocytes. As to the behavioral reactions, after the administration of prospidin, the neurotoxic action on the rats was found after 12-14 months of observation.
Lavrik
O I
OI
Shashkina
L F
LF
Ivanova
V M
VM
Nechushkina
L V
LV
Zaikina
T N
TN
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D001769:Blood / Q000187:drug effects*; D001773:Blood Cells / Q000187:drug effects; D005260:Female; D008297:Male; D009420:Nervous System / Q000187:drug effects*; D011447:Prospidium / Q000633:toxicity*; D051381:Rats; D013141:Spiro Compounds / Q000633:toxicity*; D013997:Time Factors
D000970:Antineoplastic Agents; D013141:Spiro Compounds; D011447:Prospidium; C054863:spirobromin
Gematotoksicheskoe i neĭrotoksicheskoe deĭstvie proizvodnykh dispirotripiperaziniia v khronicheskom éksperimente.