Translocation t(11;22)(q23;q11) in an adult with acute monoblastic leukemia.
A 66-year-old woman with acute monoblastic leukemia with t(11;22)(q23;q11), which was subsequently transformed into myeloblastic leukemia is reported. Such karyotype abnormality has not been reported in acute monoblastic leukemia. Cytogenetic analysis revealed 47,XX,+8,t(11;22)(q23;q11) in 19 out of 20 metaphases and 46,XX,del(7)(q22-q36),t(11;22)(q23;q11) in the remaining metaphase. Variant Ph1 was ruled out due to the absence of chimeric bcr-alb mRNAs. In remission cytogenetic findings showed normal karyotype. After 4 months, the patient relapsed with 20% myeloblasts replacing monoblasts in bone marrow. Cytogenetic analysis revealed 46,XX,del(7)(q22-q36),t(11;22)(q23;q11) in all metaphases. A possible explanation for this lineage switch may be the involvement of myelomonocytic progenitor cells.
Kobayashi
H
H
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Miyachi
H
H
Ogawa
T
T
Jimbo
M
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure*; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure*; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008969:Molecular Sequence Data; D014411:Neoplastic Stem Cells / Q000473:pathology; D012074:Remission Induction; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl