Analysis of glycosylated serum protein changes using a computer model.
The authors devised a computer model of albumin glycosylation based on irreversible glycosylation reaction of first-order kinetics. The dynamism of glycosylated albumin changes in relation to glycaemic profiles was compared with an earlier model of haemoglobin glycosylation. A non-linear regression analysis was employed to calculate the parameters of the model in three groups of patients.


CONCLUSIONS
1. Erythrocyte pool stratification accounts for the smaller clinical difference between glycosylated protein and haemoglobin than would correspond to their respective half-life values. 2. Glycosylated proteins are probably eliminated more rapidly than non-glycosylated proteins. 3. Higher levels of glycosylated proteins are occasionally at variance with model calculations, a fact which is probably due to other factors.
Svacina
S
S
3rd Chair of Internal Medicine, Charles University Medical Faculty Prague.
Hovorka
R
R
Skrha
J
J
Masek
Z
Z
D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006595:Hexosamines / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006595:Hexosamines; D012709:Serum Albumin; D000093423:Glycated Serum Albumin