[Altered composition of gangliosides in the erythrocyte membrane and in the plasma of alcoholic patients].
Gangliosides were isolated from plasma and membranes of erythrocytes of alcoholics. The pattern of gangliosides were compared with the data of healthy donors. Up to 7 fractions of gangliosides could been detected after extraction, purification by column chromatography and fractionation by TLC. In alcoholics the main ganglioside fractions of plasma GM3 were increased (52.6%) and GD3 were decreased (17.5%). The GM3 and GD1b fraction of erythrocytes membranes were decreased significantly in alcoholics.
Westphal
V S
VS
Institut für Pathologische Biochemie, Medizinischen Akademie Magdeburg.
Haselhorst
U
U
Kielstein
V
V
Schenk
H
H
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005732:Gangliosides / Q000097:blood*; D006801:Humans
D005732:Gangliosides
Veränderte Zusammensetzung für Ganglioside in den Membranen der Erythrozyten und im Plasma alkoholabhängiger Kranker.