The effect of a developing neo-intima on serotonergic and adrenergic contractions.
In the present study we used a new model, in which the positioning of a non-occlusive collar around the rabbit carotid artery results, within 7 days, in the generation of a neo-intima, a precursor lesion of atherosclerosis. We investigated the effects of this intimal proliferation on the responsiveness to serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NOR) after 1, 2 and 7 days. Already after 1 day the collar-treated arteries were more sensitive to 5-HT, but not to NOR. This sensitivity persisted over a period of 7 days. However, the development of a neo-intima diminished the maximum contractile force to NOR after 2 and 7 days, but not to 5-HT. These results demonstrate that there is a relatively selective increase in sensitivity to 5-HT during neo-intima formation, even without hyper-cholesterolaemia.
De Meyer
G R
GR
Division of Pharmacology, University of Antwerp (UIA), Wilrijk, Belgium.
Bult
H
H
Martin
J F
JF
Van Hoydonck
A E
AE
Herman
A G
AG
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D002339:Carotid Arteries / Q000294:innervation / Q000503:physiopathology; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000294:innervation / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D012701:Serotonin; D009638:Norepinephrine