The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma.
The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma.
Dyr
J E
JE
Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia.
Suttnar
J
J
Simák
J
J
Fortová
H
H
Kornalík
F
F
D000818:Animals; D001777:Blood Coagulation; D002851:Chromatography, High Pressure Liquid; D003435:Crotalid Venoms / Q000494:pharmacology*; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000032:analysis / Q000378:metabolism; D005345:Fibrinopeptide B / Q000032:analysis / Q000378:metabolism; D006801:Humans; D051381:Rats
D003435:Crotalid Venoms; D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005337:Fibrin; D005340:Fibrinogen