title: [Coronary permeability and left ventricular function following thrombolytic therapy].
abstract: We study 40 patients, 55 +/- 7 years old with acute myocardial infarction treated early by thrombolytic therapy (20 STK and 20 rt-PA). All patients were angiographically studied in the following conditions: 1) baseline, before initiating therapy. 2) Three hours after treatment. 3) Twenty four hours later. 4) Before discharge. The infarct related artery was patent 24 hours after treatment in 31 patients (78%); five of them were patent before treatment, and we observed an early reperfusion in 20 patients (57%) and late reperfusion in 6 patients (17%). The number of patients with angiographic evidence of intraluminal thrombus decreased progressively through conditions while the grade TIMI of coronary perfusion increased in the absence of reocclusion. Final regional wall motion of infarct related myocardial zones and their degree of recovery were significantly higher in recanalized patients, as compared with non-reperfused patients. Similarly, left ventricular functional recovery was higher in patients with antegrade of collateral flow to the infarct area, as compared with totally occluded patients.
authors.affiliation: Hospital Nuestra Señora del Pino, Las Palmas.
authors.forename: J
authors.initials: J
authors.lastname: Suárez de Lezo
authors.forename: A
authors.initials: A
authors.lastname: Medina
authors.forename: M
authors.initials: M
authors.lastname: Pan
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: M
authors.initials: M
authors.lastname: Sancho
authors.forename: A
authors.initials: A
authors.lastname: Bethencourt
authors.forename: M
authors.initials: M
authors.lastname: Romero
authors.forename: F
authors.initials: F
authors.lastname: Melián
authors.forename: J
authors.initials: J
authors.lastname: Segura
authors.forename: F
authors.initials: F
authors.lastname: Jiménez
mesh_terms: D017023:Coronary Angiography; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D014654:Vascular Patency; D016276:Ventricular Function
chemical_list: D005343:Fibrinolytic Agents
vernacular_title: Permeabilidad coronaria y función ventricular tras tratamiento fibrinolítico.