[Anti-anaphylactic pharmacological action of water-soluble constituents of Ginkgo biloba L. episperm].
Water-soluble constituents of Ginkgo biloba episperm 100 or 200 mg/kg po given to mice inhibited passive cutaneous allergic response and the same dose given to rats ip inhibited mast cell degranulation. It antagonized the contractile effect of isolated guinea pig ileum smooth muscles induced by the antigen. It inhibited the deliverance of SRS-A from anaphylactic lung of guinea pig.
Zhang
H
H
Yangzhou Medical College.
Xu
L
L
Jin
Q
Q
Zhou
L
L
Cheng
P
P
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013189:SRS-A