[Systemic lytic state as marker of therapeutic success after rt-PA in bolus in myocardial infarction].
OBJECTIVE
Evaluate the lytic state (LS) expressed by the level of plasmatic fibrinogen (PF) after rt-PA "in bolus" infusion for acute myocardial infarction (MI) and its relation to coronary reperfusion.


METHODS
Fifty-one patients (38 men, mean age of 53.0 +/- 9.8 years) with demonstrated occlusion of the infarct related artery (IRA) received an intravenous bolus infusion of 70 mg of rt-PA, PF was assessed before and 90 minutes after the treatment and the levels were compared in patients with (group 1) and without (group 2) reperfusion of the IRA.


RESULTS
Basal levels of PF were within the normal range in all patients. There was a decrement of 35.1% in the PF dosed at 90 minutes, from 276.8 +/- 55.5 mg/dl to 168.0 +/- 68.2 mg/dl. Both groups were similar in the levels of PF 90 after treatment (145.1 +/- 95.7 mg/dl in group 1 versus 187.0 +/- 53.7 mg/dl in group 2).


CONCLUSIONS
"In bolus" rt-PA treatment for MI significantly reduces the PF, but the LS obtained was similar in patients with or without reperfusion of the IRA.
Tranchesi Júnior
B
B
Instituto do Coração do Hospital das Clínicas, FMUSP.
Caramelli
B
B
Gebara
O C
OC
Santos Filho
R D
RD
de Albuquerque
C P
CP
Matsumoto
C
C
Bellotti
G
G
Chamone
D
D
Pileggi
F
F
D000328:Adult; D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy
D005340:Fibrinogen; D013300:Streptokinase; D010960:Plasminogen Activators
Estado lítico sistêmico como marcador do sucesso terapêutico após rt-PA em bolo no infarto do miocárdio.