[Observation on the afferent nerve activity induced by stimulation of renal receptors in the rabbits].
The effects of stimulation of renal mechano- and chemoreceptors on the afferent renal nerve activity (ARNA) were observed in 44 anesthetized rabbits. The results obtained were as follows: (1) Elevation of ureteral pressure (UP) could induce an increase in integral value of ARNA by 175.13 +/- 22.41% (P less than 0.001). (2) KCl (0.15 mol/L) and NaCl (1 mol/L) perfused retrogradely into pelvis via ureter route resulted in increase of integral value of ARNA by 253.79 +/- 21.64% and 172.17 +/- 15.19% (P less than 0.001), respectively. (3) Four patterns of afferent unit discharge were found: no spontaneous activity, regular spontaneous activity, regular spontaneous activity with burst and irregular spontaneous activity. (4) The units of afferent renal nerve with no spontaneous activity were activated markedly by elevation of UP, while the units with spontaneous activity showed no change. (5) In response to the retrograde perfusion of KCl (0.15 mol/L) and NaCl (1 mol/L) into pelvis, the activity in units with spontaneous discharge increased markedly by 210.70 +/- 23.40% and 140.07 +/- 15.72% (P less than 0.001), respectively, and the other units may be recruited concomitantly. (6) The units with no spontaneous discharge were activated by renal artery occlusion. The results implied that there are mechanoreceptor, R1 and R2 chemoreceptors in the kidney of the rabbit, and they may sense the change in UP, renal ischemia and ionic (K+, Na+) concentration of the solute within pelvis.
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Department of Physiology, Institute of Basic Medicine, Hebei Medical College.
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D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D007668:Kidney / Q000294:innervation*; D007682:Kidney Pelvis / Q000502:physiology; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D011188:Potassium / Q000652:urine; D011817:Rabbits; D012964:Sodium / Q000652:urine; D014513:Ureter / Q000502:physiology
D012964:Sodium; D011188:Potassium