Cellular immunity status in anaemia in pregnancy.
Fifty pregnant women (25 anaemic and 25 non-anaemic) and 20 non pregnant women (10 anaemic and 10 non-anaemic) were studied. All pregnant women delivered full term (37-41 wk) singleton babies. Maternal blood lymphocyte stimulation indices (SI) at 0 and 24 h were lower in anaemic and non-anaemic pregnant women, compared to anaemic and non-anaemic non-pregnant women. This difference was more marked in anaemic pregnant women, as compared to non pregnant anaemic women at 0 and 24 h respectively. The SI of maternal and cord blood lymphocytes were significantly lower in severely anaemic mothers both at 0 and 24 h and in those with maternal serum iron levels below 50 micrograms/dl or maternal per cent transferrin saturation was below 15 per cent. The anaemic mothers and their offspring were found to have significantly lower blastogenic response to PHA added at 24 h indicating depression of T-suppressor cell function.
Kandoi
A
A
Department of Paediatrics, Banaras Hindu University, Varanasi.
Bhatia
B D
BD
Pandey
L K
LK
Pandey
S
S
Sen
P C
PC
Satya
K
K
D000740:Anemia / Q000097:blood / Q000276:immunology*; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins; D011247:Pregnancy / Q000097:blood; D011250:Pregnancy Complications, Hematologic
D010835:Phytohemagglutinins