[Neurometabolic effects and antihypoxic activity of a vitamin-coenzyme complex, including thiamine pyrophosphate, lipoate, 4-phosphopantothenate, nicotinate and flavinadenine mononucleotide].
Administration of the vitamin-coenzyme complex containing thiamin pyrophosphate:lipoate:4-phosphopantothenate:nicotinate:flavinad enine mononucleotide (0.2:3:5:8:1) led to increased utilization of alpha-ketoglutarate in nervous tissue via alpha-ketoglutarate dehydrogenase and GABA-transaminase pathways. In these systems content of glutamate and GABA was decreased, suggesting their elevated consumption as energy-providing substrates. If 4-phosphopantothenate was substituted by CoASH and nicotinate--by NAD+, increased decarboxylation of 5(-14)C-alpha-ketoglutarate, 1(-14)C-GABA and 4(-14)C-Asp was detected in brain homogenates in vitro. The neurometabolic effects were accompanied by pronounced antihypoxic effects as shown by the test "hypoxy of closed space".
Rozanov
V A
VA
Abu Sali
I I
II
Rozanov
A Ia
AIa
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D003067:Coenzymes / Q000494:pharmacology; D005260:Female; D005486:Flavin Mononucleotide / Q000378:metabolism / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009417:Nerve Tissue / Q000187:drug effects / Q000378:metabolism; D009525:Niacin / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013835:Thiamine Pyrophosphate / Q000378:metabolism / Q000494:pharmacology*; D008063:Thioctic Acid / Q000378:metabolism / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D003067:Coenzymes; D014815:Vitamins; D009525:Niacin; D005680:gamma-Aminobutyric Acid; D008063:Thioctic Acid; D005486:Flavin Mononucleotide; D000612:4-Aminobutyrate Transaminase; D013835:Thiamine Pyrophosphate
Izuchenie neĭrometabolicheskikh éffektov i antigipoksicheskoĭ aktivnosti vitaminno-kofermentnogo kompleksa, vkliuchaiushchego tiaminpirofosfat, lipoat, 4-fosfopantotenat, nikotinat i flavinadeninmonanukleotid.