[Disorders of the hemostasis system in late pregnancy toxemia and their correction].
The coagulation system has been examined in 30 women with late toxemia before and after heparin and trental therapy. Pretreatment fibrinogen levels were elevated and antithrombin III levels were reduced. A hemolysate-calcium mixture showed an increase in coagulation at 8 and 10 minutes of incubation. Staphylococcus agglutination and ethanol tests revealed a significant increase in early PDF and other constituents of the fibrinogen pool. These changes were indicative of prolonged-type disseminated intravascular coagulation in late toxemia. Comprehensive therapy comprising heparin and trental leads to a significant reduction in fibrinogen concentration, alleviation of the hypercoagulatory shift and increase in antithrombin III level. Early PDF and fibrin monomer complexes showed a decline. In addition, the therapy had beneficial effects on the maternal and fetal clinical status.
Pchelkina
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Momot
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AP
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D010431:Pentoxifylline / Q000008:administration & dosage / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000209:etiology*; D011263:Pregnancy Trimester, Third
D000925:Anticoagulants; D006493:Heparin; D010431:Pentoxifylline
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