Released prophospholipase A2 activation peptides in the rapid early prediction of trauma outcome: a preliminary report.
Clinical scores of trauma severity may not be adequate measures of trauma-related systemic pathophysiology to be useful in the early prediction of individual patient outcome. This preliminary study evaluates the role of Prophospholipase A2 Activation Peptide (PLAP), measured in patient urine by modified enzyme-linked immunosorbent assay (ELISA), as an early prognostic in the severely injured. Of nine polytrauma patients requiring intensive care after a major accident, two died and one was permanently severely disabled (group 1), whilst six made a full recovery (group 2). These two groups had different ranges of urine PLAP concentration (P = 0.024). Phospholipase A2 (PLA2) activation may be an early event in tissue damage pathways that lead to multisystem organ failure (MSOF). We believe urine and plasma PLAP concentrations merit further evaluation for the early prediction of individual trauma outcome.
Fiennes
A G
AG
Department of Surgery, St. George's Hospital Medical School, London, UK.
Gudgeon
A M
AM
Jehanli
A
A
Patel
G
G
Hermon-Taylor
J
J
D000059:Accidents; D000328:Adult; D004789:Enzyme Activation; D006801:Humans; D008131:London; D008875:Middle Aged; D009104:Multiple Trauma / Q000473:pathology / Q000652:urine*; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D011890:Railroads
D011506:Proteins; C055324:phospholipase A2-activating protein