title: Chronic atrophic gastritis in a population at risk for gastric carcinoma.
abstract: Gastric mucosa of 585 patients at risk for gastric carcinoma and undergoing oesophago-gastroscopy for dyspeptic symptoms was examined histologically and histochemically. Sixteen (2.7%) of the patients studied showed gastric carcinoma. The intestinal type of gastric carcinoma was the most common, present in males over 40 yrs old, and was found in 1:16. Early cancers were present in 3 patients. Chronic atrophic gastritis of the A, B and AB types was present in 32.8%. Types A and AB were noted sporadically. Males over 40 and tobacco smokers showed the prevalence of the type B (idiopathic chronic pangastritis) and incomplete intestinal metaplasia. No relationship of the mucosal precursor lesions to sulpho- and sialomucins were detected. Helicobacter pylori infestation of gastric mucosa was present in 81% of patients and relatively common in the young patients with normal gastric mucosa; therefore this finding confirms a predilection of Helicobacter pylori to the Third World.
authors.affiliation: Department of Anatomical Pathology, University of Cape Town Medical School, South Africa.
authors.forename: K
authors.initials: K
authors.lastname: Jaskiewicz
authors.forename: H D
authors.initials: HD
authors.lastname: Louwrens
mesh_terms: D000328:Adult; D002169:Campylobacter Infections / Q000150:complications; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D009077:Mucins / Q000032:analysis; D012307:Risk Factors; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*
chemical_list: D009077:Mucins