title: [Placental transfer of tetanus antibodies and protection of newborn infants].
abstract: Total IgG and tetanus antibodies were evaluated in 2 series of mother-child pairs: 50 in Paris and 134 in Africa. All pregnancies had been normal and birth weights greater than 3 kg. Cord blood mothers tetanus antibodies ratios were 1.5 in Paris and 0.98 in Libreville (p less than 0.01) respectively. Some African children were not protected, either due to the lack of response of their mothers to immunization (2.2%) or to an insufficient antibodies transplacental transport (2.9%), or to the lack of immunization of mothers (5.9%). On the contrary, all European children were protected, in spite of low maternal antibody levels. Likewise, in Paris cord blood IgG level was 12.24 g/l vs 9.42 in mothers (cord blood/mother ratio: 1.34) and in Africa 18.4 g/l in cord blood and 22.3 g/l in mothers (cord blood/mother ratio: 0.88; p less than 0.01). The correlations between maternal IgG levels and placental transfer rates indicate that the transplacental active transfer is limited by common high IgG levels in Africa, thus contributing to a decrease in protection of neonates, especially against tetanus in which humoral responses predominate.
authors.affiliation: Département de Pédiatrie, Höpital St. Vincent de Paul, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
authors.forename: M B
authors.initials: MB
authors.lastname: Massamba
authors.forename: A
authors.initials: A
authors.lastname: Picaud
authors.forename: J L
authors.initials: JL
authors.lastname: Moreno
authors.forename: C
authors.initials: C
authors.lastname: Gendrel
authors.forename: J M
authors.initials: JM
authors.lastname: Baziomo
authors.forename: C
authors.initials: C
authors.lastname: Francoual
authors.forename: P
authors.initials: P
authors.lastname: Blot
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005602:France; D005681:Gabon; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000032:analysis; D007231:Infant, Newborn; D011247:Pregnancy; D013743:Tetanus Antitoxin
chemical_list: D007074:Immunoglobulin G; D013743:Tetanus Antitoxin
vernacular_title: Transfert placentaire des anticorps antitétaniques et protection du nouveau-né.