title: Potentiation of antitumor activity of pirarubicin by chlorpromazine in mice bearing doxorubicin-resistant P388 leukemia.
abstract: Chlorpromazine enhanced the cytotoxicity of pirarubicin against doxorubicin-resistant P388 leukemia cells in colony forming assays. Chlorpromazine also prolonged the survival of mice bearing doxorubicin-resistant P388 leukemia, when given in combination with pirarubicin.
authors.affiliation: Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: I
authors.initials: I
authors.lastname: Maekawa
authors.forename: S
authors.initials: S
authors.lastname: Furusawa
authors.forename: H
authors.initials: H
authors.lastname: Kawauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002746:Chlorpromazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice
chemical_list: D004317:Doxorubicin; C027260:pirarubicin; D002746:Chlorpromazine