Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment.
Simultaneous engraftment of maternal T cells and T cells from unrelated transfusion donor in an infant with severe combined immunodeficiency disease (SCID) was identified by HLA typing blood lymphocytes of the patient, her triplet siblings, parents, and the platelet donor from whom the patient received nonirradiated platelet transfusion. T cell grafts from both the mother and platelet donor were stable for several months, but the graft-versus-host reactions (GvHR) remained mild and immune function was deficient. We hypothesize that immunosuppressive effects of a maternal-fetal GvHR may have modified the expected lethal GvHR from platelet donor's T cells.
Vaidya
S
S
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Mamlok
R
R
Daeschner
C W
CW
Williams
J
J
Ruth
J
J
Goldblum
R M
RM
D000361:Agammaglobulinemia / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology*; D006680:HLA Antigens / Q000145:classification; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000276:immunology*; D007223:Infant; D007970:Leukopenia / Q000276:immunology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens