Neutralization of hemorrhagic snake venoms by sera of Trimeresurus flavoviridis (Habu), Herpestes edwardsii (mongoose) and Dinodon semicarinatus (Akamata).
The sera of T. flavoviridis (Habu), H. edwardsii (mongoose) and D. semicarinatus (Akamata, non-venomous snake) were tested for their capacity to neutralize 28 species of hemorrhagic snake venoms in vitro. The sera of these animals neutralized a variety of hemorrhagic venoms, suggesting a common structure for a hemorrhagic factor and a similar mechanism of neutralization for the antihemorrhagic factor in the sera. The serum of T. flavoviridis neutralized the lethal toxicity of the T. flavoviridis venom but could not neutralize those of the other hemorrhagic venoms at all. The sera of H. edwardsii and D. semicarinatus did not inhibit the activity of all hemorrhagic venoms.
Tomihara
Y
Y
Department of Habu, Okinawa Prefectural Institute of Public Health, Ozato, Japan.
Kawamura
Y
Y
Yonaha
K
K
Nozaki
M
M
Yamakawa
M
M
Yoshida
C
C
D000818:Animals; D000997:Antivenins; D003435:Crotalid Venoms / Q000276:immunology*; D006470:Hemorrhage / Q000139:chemically induced*; D008988:Herpestidae / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D012910:Snake Venoms / Q000633:toxicity*; D012911:Snakes / Q000276:immunology*; D013045:Species Specificity
D000997:Antivenins; D003435:Crotalid Venoms; D012910:Snake Venoms