title: Duplicate leader exons in the mouse liver-type alkaline phosphatase gene.
abstract: A mouse genomic region corresponding to that containing the E2 exon of the rat liver alkaline phosphatase gene was isolated and characterized. A sequence comparison of these two regions showed homology of about 85% and complete conservation of sequence stretchs around the splicing-donor site. This sequence was proved to be transcribed in the mouse liver as poly(A)+RNA. These data suggest that, together with the E1-type transcript, the mouse liver-type alkaline phosphatase gene is provided with at least two alternative leader exons.
authors.affiliation: Department of Biochemistry, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Toh
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Misumi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikehara
mesh_terms: D000469:Alkaline Phosphatase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D005091:Exons; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012326:RNA Splicing; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D000469:Alkaline Phosphatase