[Various immunochemical properties of nonspecific bacterial vaccines].
After critical evaluation of the composition and technology of preparation of nonspecific bacterial vaccines (nsb) some of them were withdrawn from the production (Neoflaminum, Neurovaccinum) and replaced with a new one (Polyvaccinum submite). Part of them were modified (media) and modernised (Panodinum, vaccine according to Delbet). Panodine produced at the present is free from bovine bile, which according to the results of the studies is strongly haemolytic for human and animal red blood cells. Thus it was justified to withdraw this component from Neoflaminum and Panodinum preparations. Purity and degree of lysis of these preparations were evaluated on the basis of ratio between nucleic acid absorbance and protein absorbance A260/A280. This allowed to determine if nsb tested are partially lysed and if their production process is reproducible. Our pilot studies on five patients suffering from infectious asthma indicate that a restoration of phagocytic activity of granulocytes and an increase of leukocytes migration after subsequent Panodine injections take place.
Aleksandrowicz
J
J
Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Janaszek
W
W
Fiejka
M
M
Matusiewicz
R
R
Dzielska
D
D
D000818:Animals; D001428:Bacterial Vaccines / Q000032:analysis / Q000276:immunology / Q000494:pharmacology*; D001646:Bile / Q000737:chemistry / Q000276:immunology*; D002417:Cattle; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D006168:Guinea Pigs; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology; D011817:Rabbits
D001428:Bacterial Vaccines
Niektóre immunochemiczne właściwości nieswoistych szczepionek bakteryjnych.