title: [Septic shock in obstetrics].
abstract: Septic shock in obstetrics is a major cause of mortality. Postpartum endometritis is often the first step of bacterial colonization inside the uterus which becomes the nidus of infection. Rapid spread into general circulation is favoured by hemodynamics patterns of pregnancy. Bacteremia would result in cardiovascular collapse and a myocardial depressant factor has been proposed to explain the fall in cardiac output. Later, endotoxin activates the substances of malignant intravascular inflammation and multiple systems organ failure may be observed in uncontrolled sepsis. Eight cases are reported hospitalized at Morelia's General Hospital, SSA, with septic shock and MSOF. Presumably because of aggressive acute resuscitation nobody succumbed during acute cardiac failure and hypotensive episode but two patients died later with multiple system organ failure. The mortality was 25%. Fluid, resuscitation, and vasoactive drugs are the most effective way to reduce mortality. Antibiotics, specific treatment of MSOF and taking away the nidus of infection are critical components of therapy.
authors.affiliation: Servicio de Gineco-Obstetricia, Hospital General Dr. Miguel Silva, SSA Morelia, Mich.
authors.forename: J A
authors.initials: JA
authors.lastname: Sereno Colo
authors.forename: J C
authors.initials: JC
authors.lastname: Pineda Marquez
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D012772:Shock, Septic / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Choque séptico en obstetricia.