title: [Synthesis and pharmacologic testing of 1-oxo-pyridazine and 1-oxo-phthalazine-2-acetic acid derivatives].
abstract: The title compounds, starting from variously substituted beta-benzoylpropionic or beta-benzoylbenzoic acids, were prepared by cyclocondensation with alpha-ethylhydrazinoacetate monohydrochloride and subsequent alcaline hydrolysis or aminolysis of the 2-carbethoxymethyl-1,2,5,6-tetrahydro-1-oxo-pyridazines or 1,2-dihydro-1-oxo-phthalazines respectively. The 1-oxo-phthalazines 42 and 34 have a weak anticonvulsive effect. Like a large number of the other synthezized compounds, they show a central sedative component and are relatively nontoxic.
authors.affiliation: Sektion Biowissenschaften der Universität Leipzig.
authors.forename: H
authors.initials: H
authors.lastname: Horn
authors.forename: E
authors.initials: E
authors.lastname: Morgenstern
authors.forename: K
authors.initials: K
authors.lastname: Unverferth
mesh_terms: D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000085:Acetates; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D010793:Phthalazines; D011724:Pyridazines
vernacular_title: Synthese und pharmakologische Testung von 1-oxo-pyridazin-bzw. 1-Oxo-phthalazin-2-essigs5aaurederivaten.