[Nutrient absorption rate from the peritoneal cavity in rats].
A study has been done of the absorption/elimination kinetics of nutritive substances such as glucose, amino acids and fats from the peritoneal cavity. For this purpose, 48 male Wistar rats were administered an intravenous or intraperitoneal "bolus" of 2 microCi of L-glucose-C14/250 g of body weight, 3 microCi of D-alanine-L-C14/250 g and 0.4 g of Intralipid/250 g body weight. A two-compartment pharmacokinetic model was applied to determine the absorption, elimination and distribution constants among the different body compartments of each of these substrates, as well as the absorption and elimination halflife. When the areas under the curves were compared following intravenous and intraperitoneal infusion, the total physiological availability or fraction of dose absorbed over a given period of time were calculated. A higher absorption and elimination constant for glucose and amino acids as compared to fats was found. Higher than 90% absorption for all substrates was found, but since in the case of fats the elimination constant is lower and longer the elimination halflife, we must be cautious regarding its infusion rate.
Mahedero Ruiz
G
G
Cátedra de Patología Quirúrgica, UNEX, Universidad de Barcelona.
Morán Penco
J M
JM
Caballero Loscos
M J
MJ
Salas Martínez
J
J
Maciá Botejara
E A
EA
Mariño Hernández
E L
EL
D000409:Alanine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D008297:Male; D010537:Peritoneum; D051381:Rats; D011919:Rats, Inbred Strains
D005217:Fat Emulsions, Intravenous; D005947:Glucose; D000409:Alanine
Velocidad de absorción de nutrientes desde la cavidad peritoneal de ratas.