Recent studies on photodamage to the eye with special reference to clinical phototherapeutic procedures.
The use of light in clinical procedures for diagnosis and treatment has raised the possibility of adverse side effects of light on the eye. Recent studies on photobinding of sensitizers to ocular tissue, photo-oxidation of lens proteins and the role of intrinsic and extrinsic photosensitizers in cataract formation are discussed. Aspects of light damage to the retina of significance in clinical phototherapeutic procedures are outlined. Future studies that may aid in documenting and minimizing the damaging effects on the eye of long-term phototherapeutic procedures are suggested.
Andley
U P
UP
Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, 02114.
Chylack
L T
LT
D003459:Crystallins / Q000378:metabolism / Q000528:radiation effects; D005123:Eye / Q000528:radiation effects*; D006801:Humans; D007834:Lasers / Q000009:adverse effects*; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects; D010777:Photochemistry; D010778:Photochemotherapy / Q000009:adverse effects*; D010789:Phototherapy / Q000009:adverse effects*; D011832:Radiation Injuries / Q000209:etiology; D012160:Retina / Q000528:radiation effects
D003459:Crystallins