[35S]methionine interaction with rat liver tRNA and effect of chemical carcinogens.
The interaction of [35S]methionine with hepatic tRNA in normal, carcinogen-treated, and partially hepatectomized rats was studied. tRNA was preferentially labeled following [35S]methionine (1.6 mCi, 25 mg/kg body wt) administration by intraperitoneal injection. The extent of [35S]methionine-tRNA interaction was impaired by partial hepatectomy and by conditions having a carcinogenic potential.
Kanduc
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Dipartimento di Biochimica e Biologia Molecolare, Facoltà di Scienze, Università di Bari, Italy.
Quagliariello
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D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000378:metabolism; D004128:Dimethylnitrosamine; D005001:Ethionine; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000493:pharmacokinetics*; D008770:Methylnitrosourea; D012343:RNA, Transfer / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013462:Sulfur Radioisotopes; D014018:Tissue Distribution
D013462:Sulfur Radioisotopes; D008770:Methylnitrosourea; D004247:DNA; D012343:RNA, Transfer; D008715:Methionine; D004128:Dimethylnitrosamine; D005001:Ethionine