Epidermal growth factor receptors in genetically induced hyperproliferative skin disorders.
The presence and morphologic distribution of epidermal growth factor receptor (EGF-R) were investigated in a variety of genetic disorders that affect human epidermis. These diseases included various forms of ichthyoses as well as restrictive dermopathy and the CHILD syndrome (congenital hemidysplasia-ichthyosiform erythroderma-limb defects). The distribution of EGF-R was detected by immunohistochemical techniques. Increased staining of immunoreactive EGF-R was frequently, but not always, seen in lesions with experimental or clinical evidence of hyperproliferation, suggesting an increased potential to respond to endogenous levels of either transforming growth factor-alpha or EGF. The finding that EGF-R levels are not always increased in congenital epidermal disorders indicated that the presence of this receptor pathway is not simply a marker for aberrant epidermis.
Nanney
L B
LB
Department of Plastic Surgery & Cell Biology, Vanderbilt University, Nashville, Tennessee.
King
L E
LE
Dale
B A
BA
D000328:Adult; D066246:ErbB Receptors / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D005315:Fetal Diseases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000235:genetics / Q000473:pathology; D007057:Ichthyosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D007231:Infant, Newborn; D015603:Keratinocytes / Q000473:pathology; D015776:Keratoderma, Palmoplantar, Diffuse / Q000151:congenital / Q000473:pathology; D007642:Keratosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D066246:ErbB Receptors