title: [The effect of x-ray irradiation on the cytochrome P-450-dependent mono-oxygenase system of the liver in different animal species].
abstract: The whole X-irradiation (7 Gy) of male rat, mouse and guinea-pig caused in general similar alterations in the content of cytochrome P-450 and aminopyrine-N-demethylase activity in liver microsomes. On the 5-7th day after irradiation the parameters were 39-79% of the normal level. The same postradiation changes were observed in females of these animal species but in females of rats and guinea-pigs the effect was less expressed. The depression of activity in liver microsomal cytochrome P-450-dependent monooxygenase system has been concluded to be one of the characteristic features of acute form in radiation damage.
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Akhalaia
authors.forename: L I
authors.initials: LI
authors.lastname: Deev
authors.forename: A G
authors.initials: AG
authors.lastname: Platonov
authors.forename: A
authors.initials: A
authors.lastname: Khakimov
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects*; D010105:Oxygenases / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013997:Time Factors; D014916:Whole-Body Irradiation
chemical_list: D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
vernacular_title: Vliianie rentgenovskogo oblucheniia na tsitokhrom P-450-zavisimuiu monooksigenaznuiu sistemu pecheni u razlichnykh vidov zhivotnykh.