title: Hydantoin derivatives. A new class of inhibitors of human leukocyte elastase.
abstract: Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly. Chymotrypsin and cathepsin G are also inhibited by these compounds.
authors.affiliation: Department of Chemistry, Wichita State University, KS 67208.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: M A
authors.initials: MA
authors.lastname: Stanga
authors.forename: J C
authors.initials: JC
authors.lastname: Castrisos
authors.forename: E J
authors.initials: EJ
authors.lastname: Schatz
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood*; D011480:Protease Inhibitors / Q000138:chemical synthesis*
chemical_list: D006827:Hydantoins; D007202:Indicators and Reagents; D009842:Oligopeptides; D011480:Protease Inhibitors; D010196:Pancreatic Elastase