On the repair of thymine and thymidine bromohydrins: a possible new model for the damage and repair of nucleic acids.
Bromohydrins (2, 3, 4, and 5), oxidatively damaged products of thymine bases, were repaired on exposure to sunlight, heat, and/or some reagents to regenerate the thymine bases. A radical mechanism is proposed for the repair reaction with sunlight and heat. A hypothesis concerning the biological significance of thymidine in deoxyribonucleic acid is presented.
Harayama
T
T
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Yanada
R
R
Akiyama
T
T
Tanaka
M
M
Fujita
Y
Y
Yoneda
F
F
D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D008956:Models, Chemical; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry
C054175:thymidine bromohydrin; C069843:thymine bromohydrin; D013941:Thymine; D013936:Thymidine