An MHC (HLA-A, -B, C2, BF, HLA-DR, GLO1) haplotype study of 497 Danish normal families with 1970 children including 97 twin pairs.
Extended MHC haplotypes comprising HLA-A, -B, -DR, C2, BF and GLO1 loci observed in the parents of 497 Danish normal families are presented, with particular regard to the haplotypes that include BF variants or the C2*2 allele. The known association of HLA-B35, -DR1 with both -A3 and -A11 appeared to depend upon the BF type: HLA-B35, BF*S, -DR1 is strongly associated with -A11, whereas -B35,BF*F,-DR1 is strongly associated with -A3. Further, in the present material DZ twins of the same sex shared HLA-haplotypes more often than did twin pairs of different sex.
Nielsen
L S
LS
Institute of Medical Genetics, University of Copenhagen, Denmark.
Eiberg
H
H
Fenger
K
K
Mohr
J
J
D003718:Denmark; D005260:Female; D005820:Genetic Testing; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D011995:Recombination, Genetic; D014427:Twins / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics
D015234:HLA-A Antigens; D015235:HLA-B Antigens; C048259:HLA-Bf antigen; D015236:HLA-C Antigens; D006684:HLA-DR Antigens