[Ultrastructural changes in thrombocytes of patients with idiopathic thrombocytopenic purpura during the treatment with vincristine].
Electron-microscopic and electron-histochemical data have been presented on platelet ultrastructural shifts in patients with idiopathic thrombocytopenic purpura 1 h, 1, 4 and 8 days after one injection of vincristine. Vincristine induces depolymerization of microtubules+, appearance of crystalloid structures in platelet cytoplasm alters the biogenesis of lysosomal enzymes; for the first time the activity of acid phosphatase has been shown in cisterns of the dense tubular system. Electron-microscopic signs of thrombocytopoiesis stimulation are revealed on day 4 after the injection. The mechanism has been shown of platelet number growth. The duration of the effect of a single low dose of vincristine is eight days, that has been evidenced by the state of the microtube structure.
Vashkinel
V K
VK
Bueva
O A
OA
Afanas'ev
B V
BV
D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008854:Microscopy, Electron; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure*; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000097:blood* / Q000188:drug therapy; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
D014750:Vincristine
Ul'trastrukturnye izmeneniia v trombotsitakh bol'nykh idiopati- cheskoĭ trombotsitopenicheskoĭ purpuroĭ pri lechenii vinkristinom.