title: MR studies of brain oedema in the developing animal.
abstract: Assessment of perinatal brain oedema is complicated by normal changes in brain water that accompany the marked physiological, biochemical and morphological alterations occurring during this phase of development. Multiexponential analysis of transverse decay curves (TDCs), derived from 128 echo CPMG images, of white matter (WM) made oedematous by either exposure of animals to triethyltin (TET) or cryogenic cortical lesions revealed a second, slower decay component not apparent in controls. More significantly, an obvious difference was noted between the TET and cryogenic lesion fast decay components which might serve as a basis to differentiate non-invasively cytotoxic and vasogenic oedemas.
authors.affiliation: Department of Neurosurgery, Children's Hospital, Boston, Massachusetts.
authors.forename: A V
authors.initials: AV
authors.lastname: Lorenzo
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: S T
authors.initials: ST
authors.lastname: Wong
authors.forename: V M
authors.initials: VM
authors.lastname: Colucci
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000175:diagnosis* / Q000378:metabolism; D002540:Cerebral Cortex / Q000502:physiology; D000860:Hypoxia / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism; D014267:Triethyltin Compounds / Q000494:pharmacology
chemical_list: D014267:Triethyltin Compounds; C031575:triethyltin