Effects of an oral fat load on some prothrombotic markers in coronary heart patients.
The Authors studied the effects of an oral fat load with saturated fats on some recently identified molecular markers in order to assess a change in clotting balance in a prothrombotic sense. The series consists of 30 female subjects (mean age 46 +/- 4 yrs) suffering from coronary heart disease in the chronic phase (previous myocardial infarction, angor). Each subjects was kept on a standard diet and without drugs influencing the lipid and clotting balance. A venous blood withdrawal was done after an overnight fasting and three hours after an oral fat load (butter g 1/kg). For each sample the plasma levels of triglycerides, total cholesterol (enzymatic method), beta-thromboglobulin, d-dimer and tissue plasminogen activator (immunoenzymatic ELISA Methods, Boehringer Mannheim) were determined. The oral fat load caused a significant increase in triglycerides (p less than 0.05), whereas total cholesterol values remained almost unchanged. The values of beta-thromboglobulin showed a significant (p less than 0.05) reduction, whereas the ones of D-dimer (D-D) and tissue plasminogen activator showed a slight but not significant increase. The results demonstrated that the oral fat load did not cause any hemostatic change in prothrombotic sense; moreover, a reduction of the platelet activation is notable, probably dependent on the consumption of endogenous heparin involved in the lipoproteinlipase release.
Ferlito
S
S
Institute of Medical Clinic I, University of Catania, Italy.
Di Mauro
C
C
D000328:Adult; D015415:Biomarkers; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
D015415:Biomarkers; D004041:Dietary Fats; D008055:Lipids