Effect of leu-(Asp, Asn, Glu, Gln) dipeptides on platelet aggregation in vitro.
A series of Leu-(Asp, Asn, Glu, Gln) dipeptides were synthesized and tested for their effect on human platelet aggregation in vitro induced by collagen, ADP, or adrenaline. It was found that only Leu-Asp-NH2 and Leu-Asn-NH2 inhibit rather strongly platelet aggregation, whereas a small inhibition was observed with Leu-Glu-NH2 and Leu-Gln-NH2, respectively.
Liakopoulou-Kyriakides
M
M
Dept. of Chemical Engineering, Aristotelian University of Thessaloniki, Greece.
Stavropoulos
G
G
Karagiannis
C
C
Calogridis
P
P
Sinakos
Z
Z
D000244:Adenosine Diphosphate / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D004151:Dipeptides; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D003094:Collagen; D007930:Leucine; D004837:Epinephrine