title: [Pharmacological correction of ketamine-impaired spatial memory of rats].
abstract: Ketamine in dose 10 mg/kg increased the number of erroneous choices of rats with spatial strategy and didn't effect searching accuracy of rats with non-spatial strategy in 8-arm radial maze. Ketamine in doses 1 and 5 mg/kg disrupted rat short-term memory in delayed response reaction. Physostigmine and aspartic acid, but not haloperidol, diminished ketamine amnesia, therefore ketamine impaired the interaction of cholinergic and glutamate/aspartatergic neurons of hippocampal areas.
authors.forename: G V
authors.initials: GV
authors.lastname: Kovalev
authors.forename: V A
authors.initials: VA
authors.lastname: Sazhin
authors.forename: I P
authors.initials: IP
authors.lastname: Kuleshova
mesh_terms: D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D007649:Ketamine / Q000009:adverse effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D013037:Spatial Behavior
chemical_list: D001224:Aspartic Acid; D007649:Ketamine; D010830:Physostigmine; D006220:Haloperidol
vernacular_title: Farmakologicheskaia korrektsiia narushennoĭ ketaminom prostranstvennoĭ pamiati krys.