title: Renal tubular hypouricemia: evidence for defect of both secretion and reabsorption.
abstract: Two patients had hypouricemia due to increased uric acid clearance. They showed no decrease of urate clearance to creatinine clearance ratio (Cua/Ccr) following pyrazinamide administration, and no increase of Cua/Ccr after probenecid. One patient showed a limited decline in Cua/Ccr after intravenous furosemide. In the other patient, neither acetylsalicylate nor furosemide produced any noticeable change in Cua/Ccr. Both showed a normal diuretic response after intravenous furosemide. The results indicate that they had massive defects in urate transport along the nephron, probably including both secretion and reabsorption.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shichiri
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Iwamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000368:Aged; D001241:Aspirin; D003404:Creatinine / Q000097:blood; D005665:Furosemide; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011339:Probenecid; D011718:Pyrazinamide; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D011718:Pyrazinamide; D005665:Furosemide; D003404:Creatinine; D011339:Probenecid; D001241:Aspirin