Intracerebroventricular infusions of insulin increase vasopressin release in rats.
1. The role of cerebral insulin or insulin-like immunoreactive substance (ILI) on arginine-vasopressin (AVP) release using rats was investigated. Feeding rats with a high salt diet for 4 weeks significantly decreased the contents of ILI in both the hypothalamus and pituitary gland. Intracerebroventricular infusions of insulin (4 and 40 micrograms/min for 30 min) increased plasma AVP concentrations dose-dependently without hypoglycaemia, but decreased hypothalamic and pituitary contents of AVP. 2. These results indicate that ILI in the brain may play a role in the secretion of AVP, and that this mechanism could be operated to control a water-sodium balance.
Nishimura
M
M
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
Takahashi
H
H
Matsusawa
M
M
Ikegaki
I
I
Nakanishi
T
T
Hirabayashi
M
M
Yoshimura
M
M
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology; D002552:Cerebral Ventricles / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001685:Biological Factors; D007328:Insulin; D001127:Arginine Vasopressin