title: Malignant Sertoli and Leydig cell tumour in a boar.
abstract: A rare case of Sertoli and Leydig cell tumour was investigated in a 6-month-old boar. The neoplasm was found in the right testis and had metastasized to the liver, spleen, kidneys and diaphragmatic peritoneum. Metastatic nodules were also present in the tissues near the right testis and some neoplastic cells were present in the superficial inguinal lymph node. The neoplastic cells exhibiting severe pleomorphism were divided into Sertoli and Leydig cell types, although in some sites, it was not possible to classify tumour cells clearly as Sertoli or Leydig in type. In the metastatic lesions there were anaplastic Sertoli cells with abundant collagen fibres. Some neoplastic Sertoli cells and a few neoplastic Leydig cells revealed cytoplasmic reactivity for testosterone. Ultrastructurally, the neoplastic cells were characterized by mitochondria with tubulovesicular cristae, smooth endoplasmic reticulum, membranous structures, lysosomes, lipofuscin granules or lipid droplets.
authors.affiliation: Kensei Meat Inspection Office, Prefecture of Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mabara
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000556:secondary / Q000662:veterinary; D007984:Leydig Cell Tumor / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D013160:Splenic Neoplasms / Q000556:secondary / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000473:pathology*; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone