[Detection of B-cell marker of rheumatism using monoclonal antibodies D8/17 in the families of patients with rheumatism].
To study hereditary disposition for rheumatism (R) 141 persons including 26 probands of patients with R, 79 relatives and also 12 newborns of mothers with R were examined. The carriage of the B-cell markers was studied by means of antibodies D8/17. The B-cell marker was revealed in 96.2 per cent probands and in 41.4 per cent relatives. Among the female relatives with R the B-cell marker carriage was revealed in 51.2 per cent, among the male relatives in 25.9 per cent. A high carriage of the given marker in children and young people aged 4-34 born of mothers with R was noted (66.7 per cent). Among the newborn no carriers of the B-cell marker were detected. A conclusion has been made of the participation of the B-cell marker in the formation of hereditary predisposition for R.
Shostak
N A
NA
Anokhin
V N
VN
Zolkina
I V
IV
Morozova
E I
EI
Kazakova
T V
TV
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012216:Rheumatic Diseases / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte
Vyiavlenie B-kletochnogo markera revmatizma s pomoshch'iu monoklonal'nykh antitel D8/17 v sem'iakh bol'nykh revmatizmom.