title: [Contents and batch-dependent variations of mineral substances in milk formula for premature infants and possible effects on renal acid burden].
abstract: The mineral contents of Na, K, Ca, Mg, Cl and P was determined in different batches of 5 preterm formulas. The purpose of this study was 1st to investigate whether the analytical data are in agreement with the specifications of the manufactures and 2nd whether there are large variations between different batches of the same formula. For each analyzed mineral we found marked differences between the specifications and our measurements in at least one of the formulas. In these cases the differences between the labels and the medians of the analytical data were larger than half of the range of all determinations of the respective formula. Without exception the mean values for K were all clearly lower than the specifications of the producers. In 4 of the 5 premature formulas variation coefficients greater than 10% were observed for at least one mineral. The results show that coincidental variations of mineral contents in different batches can result in a disadvantageous mineral composition because of synergistic effects on metabolism. In this context the importance of the sum of Na and K over Cl in premature formulas is stressed with regard to renal acid excretion. The introduction of more stringent quality standards is proposed.
authors.affiliation: Forschungsinstitut für Kinderernährung, Dortmund.
authors.forename: T
authors.initials: T
authors.lastname: Remer
authors.forename: B
authors.initials: B
authors.lastname: van Eyll
authors.forename: H G
authors.initials: HG
authors.lastname: Tölle
authors.forename: F
authors.initials: F
authors.lastname: Manz
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000818:Animals; D006801:Humans; D007225:Infant Food / Q000032:analysis*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007668:Kidney / Q000502:physiology*; D008892:Milk / Q000737:chemistry*; D008903:Minerals / Q000008:administration & dosage / Q000032:analysis*; D009751:Nutritional Requirements; D012015:Reference Standards
chemical_list: D008903:Minerals
vernacular_title: Gehalte und chargenabhängige Schwankungen verschiedener Mineralstoffe in Frühgeborenen-Milchnahrungen sowie mögliche Effekte auf die renale Säurelast.