title: Vitamin E status in newborn lambs with special reference to the effect of dl-alpha-tocopheryl acetate supplementation in late gestation.
abstract: Pregnant ewes were supplemented with dl-alpha-tocopheryl acetate, either as a single intramuscular dose (500 mg two weeks before lambing) or perorally (150 mg daily during 3-4 weeks before lambing). Ewes without such a supplementation were controls. The vitamin E supplemented ewes had nearly twice as high vitamin E (alpha-tocopherol) concentrations as the unsupplemented control ewes at lambing both in serum and in colostrum. The vitamin E concentration in colostrum was 5-11 higher than in milk 1 week after lambing. Both supplementations somewhat increased the vitamin E serum concentration of the newborn lambs, but the increase was negligible in comparison with the effect produced by the consumption of colostrum. All lambs had very low serum concentrations at birth. The lambs from the supplemented ewes had significantly higher serum values than the control lambs 24 h after birth. The ewes had somewhat higher selenium status at birth than their offsprings when evaluated by glutathione peroxidase (GSH-Px) in the erythrocytes. It seems reasonable that nutritional muscular degeneration may arise in newborn lambs with a normal selenium status if their vitamin E status is critical, either because of an inadequate consumption of colostrum or because of a vitamin E deficient diet during pregnancy with a low vitamin concentration of colostrum as a consequence.
authors.affiliation: Experimental Station, Veterinary Institute, Skara, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Pehrson
authors.forename: J
authors.initials: J
authors.lastname: Hakkarainen
authors.forename: L
authors.initials: L
authors.lastname: Blomgren
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007743:Labor, Obstetric / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D012756:Sheep / Q000097:blood*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood*
chemical_list: D014810:Vitamin E