[Functional concept of the initiation of blood coagulation by cell membranes].
According to the conception proposed, blood coagulation is initiated by Ca(2+)-induced rearrangement of the bilayer structure of native cell membranes into heterophasic. The thrombogenic action is realized through Ca2+ entering the cell cytoplasm. This leads to phosphatidyl serine translocation into the surface monolayer of the membrane, its clustering and the arising of phosphatidyl ethanolamine mesophases. Vitamin K-dependent coagulation factors are bound at the boundaries of clusters and mesophases of these phospholipids through Ca2+ ions. They form enzyme complexes functioning due to the matrix structure of phospholipid surface as units of thrombin generation.
Zubairov
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DM
Timerbaev
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VN
D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010714:Phosphatidylethanolamines / Q000502:physiology; D010718:Phosphatidylserines / Q000502:physiology; D011188:Potassium / Q000502:physiology; D013917:Thrombin / Q000096:biosynthesis; D014812:Vitamin K / Q000502:physiology
D001779:Blood Coagulation Factors; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D014812:Vitamin K; D013917:Thrombin; D011188:Potassium; D002118:Calcium
Funktsional'naia kontseptsiia initsirovaniia svertyvaniia krovi kletochnymi membranami.