[The effect of androgens and somatotropic hormone on the expression of the level of special estrogen-binding protein in the hepatocytes].
The possibility of direct androgen determination of high unusual estrogen-binding protein (UEBP) level in female rat hepatocytes to the level typical to the males was studied. The direct effect of androgen (A) on the UEBP content in hepatocytes of ovariectomized female rats was shown by estimation in vivo and on hepatocyte culture. It has been revealed that the permissive action of growth hormone (GH) is necessary for normal expression of direct androgen effect. The latter has been stable after cessation of hormone action. High concentration of GH was found to possess positive regulatory effect on the UEBP in hepatocytes of ovariectomized rats. Effect of GH quickly disappeared after hormone withdrawal and was under negative regulation by physiological concentrations of A. It was concluded that A owing to its direct action together with permissive influence of GH is capable of determining stable expression of male phenotype of the UEBP level in hepatocytes of females.
Vishniakova
T G
TG
Smirnova
O V
OV
Bocharov
A V
AV
Rozen
V B
VB
D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010052:Ovariectomy; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism; D045165:Testosterone Congeners / Q000494:pharmacology*
D002352:Carrier Proteins; D011960:Receptors, Estrogen; D045165:Testosterone Congeners; C010140:estrophilin; D013006:Growth Hormone
Vliianie androgenov i somatotropnogo gormona na ékspressiiu urovnia osobogo éstrogensviazyvaiushchego belka v gepatotsitakh.