[Degradation of diazepam in aqueous solution. Simulation essay by action of diluted hydrogen peroxide].
The mild oxidation of diazepam by hydrogen peroxide in neutral medium at room temperature in daylight is reported. The oxidation product has been isolated and purified and its purity determined by thin layer chromatography. It has been identified by spectroscopy, chiefly by infrared and mass spectroscopy. Finally it has been compared, by high pressure liquid chromatography, to the product from an aqueous diazepam solution placed 6 months at room temperature in daylight.
De Souza
A
A
Laboratoire de Chimie analytique, Faculté de Pharmacie, Université Fédérale Fluminense, Niteroi RJ, Brésil.
Hamon
M
M
D002855:Chromatography, Thin Layer; D003975:Diazepam / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D012996:Solutions; D013055:Spectrophotometry, Infrared
D012996:Solutions; D006861:Hydrogen Peroxide; D003975:Diazepam
Dégradation du diazépam en solution aqueuse. Essai de simulation par action du peroxyde d'hydrogène en solution diluée.