Short term inhalation of bromobenzene: methodology and absorption characteristics in mouse, rat and rabbit.
In a dynamic inhalation system, mice, rats and rabbits were exposed to bromobenzene vapour (250-3400 p.p.m.) for 4 hr. Blood concentrations of bromobenzene were determined by head-space gas chromatography. After inhalation of 1000 p.p.m. for 4 hr, concentrations of 153, 102 and 47 micrograms bromobenzene/ml blood were found in mice, rats and rabbits, respectively. In vitro experiments showed a blood/air partition coefficient at 37 degrees of approximately 200, which was reflected by a linear uptake of bromobenzene up to an air concentration of 2500 p.p.m. Compared with results obtained previously by intraperitoneal bromobenzene administration inhalation resulted in higher blood concentrations.
Aarstad
K
K
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Norway.
Becker
R
R
Dahl
J
J
Dybing
E
E
Nilsen
O G
OG
D000042:Absorption; D000280:Administration, Inhalation; D000818:Animals; D001969:Bromobenzenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002849:Chromatography, Gas / Q000379:methods; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001969:Bromobenzenes; C032036:bromobenzene