On the possibility of differential diagnosis at elevated erythrocyte sedimentation rate by analysis of the concentrations of blood plasma proteins--a model study.
An elevated erythrocyte sedimentation rate is generally regarded as an unspecific and mostly pathological indicator of inflammation or tumour. However, we have determined the concentrations of plasma/serum proteins that influence the erythrocyte sedimentation rate in numerous samples from several groups of patients with different diseases, including 2 forms of cancer. Equations have been developed by which the 1 h value of erythrocyte sedimentation rate can be expressed as the sum of disease-specific coefficients for each protein multiplied by the measured concentrations of the respective proteins. These equations are shown to be disease-specific with 64-93% probability. Such equations may thus form the basis for differential diagnosis.
Ruhenstroth-Bauer
G
G
Max-Planck-Institut für Biochemie, Martinsried, Germany.
Schedler
K
K
Scherer
R
R
Vesterberg
O
O
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D001799:Blood Sedimentation; D003937:Diagnosis, Differential; D004886:Erysipelas / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000175:diagnosis; D009443:Neuritis / Q000097:blood / Q000175:diagnosis; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis
D001798:Blood Proteins