Effects of ceruletide, administered singly and in combination with central-acting drugs, on discrete shuttle avoidance response in mice.
The single administration of ceruletide at 10-300 micrograms/kg, i.p., slightly but significantly decreased the response rate (frequency of shuttles) under a discrete avoidance task in mice. Over 10 micrograms/kg of ceruletide attenuated the increase in the response rate induced by methamphetamine (0.5 mg/kg, s.c.). However, ceruletide, at 1-300 micrograms/kg, did not significantly enhance the response- and/or avoidance-decreasing effects of chlorpromazine (1 mg/kg, s.c.), haloperidol (0.1 mg/kg, s.c.), pilocarpine (4 mg/kg, s.c.) and N6-(L-2-phenylisopropyl)-adenosine (0.1 mg/kg, s.c.), but rather tended to reduce the avoidance-decreasing effect of chlorpromazine and pilocarpine at 1-100 micrograms/kg.
Kuribara
H
H
Division for Behavior Analysis, Gunma University School of Medicine, Maebashi, Japan.
Asami
T
T
Ida
I
I
Tadokoro
S
S
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*
D011619:Psychotropic Drugs; D010862:Pilocarpine; D010660:Phenylisopropyladenosine; D008694:Methamphetamine; D002108:Ceruletide; D006220:Haloperidol; D002746:Chlorpromazine