Effect of 3,3'-iminodipropionitrile on experimental intravitreal proliferation in albino rabbits.
The effect of 3,3'-iminodipropionitrile (IDPN) on experimental intravitreal proliferation in albino rabbits was studied by light and electron microscopy. About 2.5 x 10(5) tissue cultured fibroblasts were injected into the vitreous cavity of albino rabbits. Immediately after the injection, phosphate-buffered solution (PBS) or IDPN was injected into the vitreous cavity. Four weeks later, traction retinal detachment was seen in 12 of 18 control eyes (67%), 6 of 10 eyes treated with 20 mg IDPN (60%), 5 of 10 eyes treated with 40 mg IDPN (50%), and 3 of 20 eyes treated with 80 mg IDPN (15%). The intravitreal injection of 80 mg of IDPN inhibited traction detachment significantly. In eyes treated with 80 mg of IDPN, fibroblasts in the proliferative tissue were slender, irregularly arranged, and mostly degenerated. Collagen fibers were slender and fragmented. These results indicate that the intravitreal injection of IDPN might be helpful in the therapy for proliferative vitreoretinopathy.
Akiyama
K
K
Department of Ophthalmology, Nagasaki University School of Medicine, Nagasaki-shi, Japan.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003094:Collagen / Q000648:ultrastructure; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012163:Retinal Detachment / Q000601:surgery; D012164:Retinal Diseases / Q000473:pathology / Q000517:prevention & control; D014822:Vitreous Body / Q000187:drug effects* / Q000648:ultrastructure
D009570:Nitriles; C008110:3,3'-iminodipropionitrile; D003094:Collagen