title: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.
abstract: The decomposition of ginsenoside Rb2 (Rb2) in the rat large intestine after oral administration was investigated in detail. A part of Rb2 was decomposed and six decomposition products (I-VI) were observed on thin-layer chromatogram. Among them, five products (I-V) were isolated, and identification of these compounds was done by carbon-13 nuclear magnetic resonance (13C-NMR). On the basis of 13C-NMR analysis, these compounds were identified as ginsenoside Rd (I), 3-O-beta-D-glucopyranosyl-20-O- [alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S)- proto-panaxadiol (II), ginsenoside F2 (III), 20-O-[alpha-L-arabinopyranosyl(1----6)-beta-D-glucopyranosyl]-20(S )- protopanaxadiol (IV), and compound K (V), respectively.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Karikura
authors.forename: T
authors.initials: T
authors.lastname: Miyase
authors.forename: H
authors.initials: H
authors.lastname: Tanizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takino
authors.forename: T
authors.initials: T
authors.lastname: Taniyama
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D036145:Ginsenosides; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D005894:Panax; D010946:Plants, Medicinal; D051381:Rats; D012503:Saponins / Q000378:metabolism / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D036145:Ginsenosides; D000960:Hypolipidemic Agents; D012503:Saponins; C048026:ginsenoside Rb2