Antagonism to neuronal cystine uptake a factor in neuronal damage by glutamate.
Glutamate neurotoxicity has been attributed to excessive excitatory action of this amino acid and related analogues. Recent studies using in-vitro neuronal cell culture techniques have implicated antagonism to neuronal cystine uptake and subsequent cellular glutathione depletion as factors in neuronal cytotoxicity caused by glutamate.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003553:Cystine / Q000037:antagonists & inhibitors*; D005971:Glutamates / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects*
D005971:Glutamates; D003553:Cystine