CSF oligoclonal banding pattern changes in a long-surviving SSPE patient treated with alpha-IFN.
Oligoclonal bands are a constant, non-modifiable feature of CSF examination in SSPE. We studied CSF oligoclonal IgG banding pattern in a long-surviving SSPE patient treated with serial courses of intrathecal alpha-IFN. alpha-IFN administration did not significantly modify the clinical status of the patient. Oligoclonal IgG banding pattern varied during the 58 month-long treatment. Oligoclonal bands disappeared at the end of the first course only to reappear during the third course, 2 years later, with a different electrophoretic pattern. We conclude that oligoclonal bands may transiently disappear from the CSF of long-surviving SSPE patients. Although alpha-IFN treatment induces no clinical improvement, it might affect the quality of Ig production.
Grimaldi
L M
LM
Clinica Neurologica IV Università di Milano, IRCCS, Ospedale San Raffaele.
Martino
G V
GV
D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid* / Q000276:immunology; D007278:Injections, Spinal; D007370:Interferon Type I / Q000008:administration & dosage*; D007525:Isoelectric Focusing; D043025:Oligoclonal Bands; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000276:immunology; D013997:Time Factors
D007136:Immunoglobulins; D007370:Interferon Type I; D043025:Oligoclonal Bands