title: Radiation therapy for primary carcinoma of the extrahepatic biliary system. An analysis of 63 cases.
abstract: From 1976 to 1988, 63 patients received radiation therapy for primary cancers of the extrahepatic biliary system (eight gallbladder and 55 extrahepatic biliary duct). Twelve patients underwent orthotopic liver transplantation. Chemotherapy was administered to 13 patients. Three patients underwent intraluminal brachytherapy alone (range, 28 to 55 Gy). Sixty patients received megavoltage external-beam radiation therapy (range, 5.4 to 61.6 Gy; median, 45 Gy), of whom nine received additional intraluminal brachytherapy (range, 14 to 45 Gy; median, 30 Gy). The median survival of all patients was 7 months. Sixty patients died, all within 39 months of radiation therapy. One patient is alive 11 months after irradiation without surgical resection, and two are alive 50 months after liver transplantation and irradiation. Symptomatic duodenal ulcers developed after radiation therapy in seven patients but were not significantly related to any clinical variable tested. Extrahepatic biliary duct cancers, the absence of metastases, increasing calendar year of treatment, and liver transplantation with postoperative radiation therapy were factors significantly associated with improved survival.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: A H
authors.initials: AH
authors.lastname: Epstein
authors.forename: S
authors.initials: S
authors.lastname: Iwatsuki
authors.forename: B I
authors.initials: BI
authors.lastname: Carr
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
mesh_terms: D001650:Bile Duct Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D001918:Brachytherapy; D002277:Carcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D003131:Combined Modality Therapy; D004381:Duodenal Ulcer / Q000209:etiology; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries; D011879:Radiotherapy Dosage; D015996:Survival Rate