A collaborative study of cancer incidence and mortality among vinyl chloride workers.
A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).
Simonato
L
L
International Agency for Research on Cancer, Lyon, France.
L'Abbé
K A
KA
Andersen
A
A
Belli
S
S
Comba
P
P
Engholm
G
G
Ferro
G
G
Hagmar
L
L
Langård
S
S
Lundberg
I
I
D000328:Adult; D001932:Brain Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D002423:Cause of Death; D015331:Cohort Studies; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D008223:Lymphoma / Q000139:chemically induced / Q000453:epidemiology; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D014752:Vinyl Chloride / Q000009:adverse effects*
D014752:Vinyl Chloride