title: Improvement of diagnosis in the non-invasive assessment of coronary artery disease: enhanced evaluation of quantitative exercise 201thallium imaging by multivariate analysis.
abstract: OBJECTIVE
  The aim was to evaluate discriminant analysis, performed in patients without prior myocardial infarction, in enhancing the diagnostic value of quantitative exercise 201thallium scintigraphy.
  
  
  METHODS
  All clinical, electrocardiographic, and scintigraphic variables were first subjected to a univariate analysis. Afterwards a discriminant analysis was done.
  
  
  METHODS
  135 patients (104 male) were studied. Age was 24-70 years, mean 55 years.
  
  
  RESULTS
  Two discriminant analyses were done. In the first analysis, the ability to detect the presence of coronary artery disease was tested. Significant variables were: (1) history of angina, (2) sex, (3) quantitative analysis of 201thallium scintigraphy, (4) age, (5) ischaemic ST response, (6) angina during the test, and (7) the pressure-rate product. The sensitivity, specificity, and accuracy of classification using the discriminant function were 91%, 87%, and 90%, respectively. The sensitivity was higher than when using only visual interpretation (sensitivity 70%; p less than 0.0002) or quantitative interpretation (sensitivity = 66%; p less than 0.0001) of thallium scans, without significant loss of specificity (p less than 0.5488; p less than 0.6875). In the second analysis, a discriminant function was calculated to detect multivessel disease. Five input variables were selected: (1) number of vessels with stenosis predicted by quantitative analysis, (2) number of vessels with stenosis predicted by visual analysis, (3) ischaemic ST response, (4) sex, (5) angina during the test. Multivariate analysis showed an increase in sensitivity when compared with visual interpretation (78% v 55%; p less than 0.0043) and quantitative analysis (66%; p less than 0.0156). Using the classification, the discriminant function was more accurate than visual analysis (81% v 69%) or quantitative analysis (77%).
  
  
  CONCLUSIONS
  The results show that multivariate analysis of non-invasive test results in quantitative thallium exercise testing allows convenient use for clinical purposes with improved results.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
authors.forename: M G
authors.initials: MG
authors.lastname: Niemeyer
authors.forename: A H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: M J
authors.initials: MJ
authors.lastname: Cramer
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: F J
authors.initials: FJ
authors.lastname: Verzijlbergen
authors.forename: A
authors.initials: A
authors.lastname: Breeman
authors.forename: C A
authors.initials: CA
authors.lastname: Ascoop
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D016002:Discriminant Analysis; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes