[An autopsy case of cyclophophamide-induced interstitial pneumonia].
A 72-year-old female with malignant lymphoma, receiving oral cyclophosphamide (CPA) and prednisone, developed severe pulmonary insufficiency 56 days after the start of CPA (total dosages 8.5 g). A chest roentgenogram showed a diffuse interstitial shadow throughout both lungs, and CT scan revealed increased density, most prominent in the central zones, and a thickening of bronchovascular bundles. She was diagnosed from the clinical course and the postmortem examination as having cyclophosphamide-induced interstitial pneumonia. Interstitial pneumonia as a side-effect of cyclophosphamide is very rare in Japan. The clinical and pathological findings in this case and a review of the literature on 38 other cases world-wide are reported.
Tanaka
H
H
Department of Internal Medicine (Section 3), Sapporo Medical College, Japan.
Hirasawa
M
M
Ohshima
S
S
Shimoyama
N
N
Ishidate
T
T
Suzuki
A
A
D000368:Aged; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D003520:Cyclophosphamide