Age-related calmitine distribution in mitochondria of normal and mdx mouse skeletal muscle.
In our study, mitochondria were isolated from skeletal muscle in 3-, 5-, 6- and 16-week-old mdx and control mice. A deficit was observed in a calcium-specific mitochondrial protein (named "calmitine") in 3-, 5- and 6-week-old mdx mice but only in 3-week-old control mice. In addition, there was a correlation between the amounts of calmitine and calcium uptake in mitochondria: the latter remained low in 3-, 5- and 6-week-old mdx mice and was similar to controls in 16-week-old mdx mice (as was calmitine). A relationship is suggested between the deficit in calmitine (and calcium uptake in mitochondria) and the important signs of fiber degeneration presented by mdx mice between 3 and 6 weeks of age (a return to normal was observed subsequently).
Lucas-Héron
B
B
Laboratoire de Physiologie, U.E.R. de Médecine, Nantes et Unité CNRS, France.
Schmitt
N
N
Ollivier
B
B
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000032:analysis*; D051379:Mice; D008817:Mice, Mutant Strains / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000737:chemistry* / Q000648:ultrastructure; D009132:Muscles / Q000648:ultrastructure*; D009137:Muscular Dystrophy, Animal / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D002135:Calcium-Binding Proteins; D002118:Calcium