[Irreversible changes in energy processes in the mitochondria after chronic exposure to detergents].
Chronic inhalational exposure of white rats to a synthetic detergent 'LOTOS' in concentrations 25 and 100 mg/m3 caused liver mitochondria bioenergetics changes from a reversible low energetic shift up to an irreversible mitochondria damage of an organ-structural character. The degree of the damaging effect depended on the duration of exposure and the concentration of the detergent.
Kalashnikov
A A
AA
Zhivotnikova
N V
NV
D000280:Administration, Inhalation; D000818:Animals; D003864:Depression, Chemical; D003902:Detergents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D008954:Models, Biological; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D003902:Detergents
Neobratimye izmeneniia énergeticheskikh protsessov v mitokhondriiakh pod vliianiem khronicheskogo vozdeĭstviia detergenta