title: The initiation of chromosomal DNA replication in eukaryotes.
abstract: Eukaryotic DNA replication initiates at many sites on each chromosome during the S phase of the cell cycle. Each origin of replication lies in a unique chromosomal environment and can be regulated in different cell types both at the level of utilization and the time of initiation during S phase. In this review, we examine the control and the mechanism of eukaryotic origin function.
authors.affiliation: Cold Spring Harbor Laboratory, NY 11724.
authors.forename: J F
authors.initials: JF
authors.lastname: Diffley
authors.forename: B
authors.initials: B
authors.lastname: Stillman
mesh_terms: D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000648:ultrastructure; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D016196:S Phase / Q000235:genetics