title: Examination of the neuroendocrine basis for the social conflict-induced enhancement of immunity in mice.
abstract: Intruder DBA/2 and C57BL/6 mice, which display different neuroendocrine responses to social conflict, evidence a pronounced increase in splenocyte phagocytosis of opsonized zymosan particles as a consequence of social conflict-induced stress. Interruption of the hypothalamic-pituitary-adrenal axis prior to social conflict results in an abrogation of the stress-induced enhancement of phagocytosis in DBA/2, but not in C57BL/6, mice. Administration of the opiate antagonists naloxone and naltrexone resulted in a potentiation of the stress-induced enhancement of phagocytosis in both strains. Similarly, administration of the alkylating antagonist beta-chlornaltrexamine which irreversibly blocks opioid binding sites potentiated the immune-enhancing effects of social conflict stress. Mitogen-induced T and B lymphocyte proliferation was unaffected by any of the experimental procedures with the exception of beta-chlornaltrexamine which suppressed activity equally in stressed and nonstressed groups. These results demonstrate the necessity of employing inbred murine strains in the dissection of the neuroendocrine pathways which govern stress-induced modulation of the immune system.
authors.affiliation: Department of Biological Sciences, Mankato State University, MN 56002.
authors.forename: M
authors.initials: M
authors.lastname: Lyte
authors.forename: S G
authors.initials: SG
authors.lastname: Nelson
authors.forename: B
authors.initials: B
authors.lastname: Baissa
mesh_terms: D000374:Aggression / Q000502:physiology*; D000378:Agonistic Behavior / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000502:physiology*; D003220:Conflict, Psychological; D004723:Endorphins / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007121:Immunocompetence / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010913:Pituitary-Adrenal System / Q000502:physiology*
chemical_list: D004723:Endorphins