title: Morphologic changes in the lungs of cats experimentally infected with Dirofilaria immitis. Response to aspirin.
abstract: The morphologic response of the pulmonary arteries and lungs in cats was studied after a five month heartworm infection produced by transplantation of four adult heartworms/cat. One group of seven heartworm infected cats was not treated, another group of seven cats was treated with 97.5 mg of aspirin given twice a week, and the third group of six cats was given aspirin at a sufficient dosage to block in vitro platelet aggregation throughout the study. A fourth group of eight noninfected cats served as controls. Five months after heartworm infection, the cats were euthanized and the lungs perfusion fixed for light microscopy and scanning electron microscopy of the pulmonary arterial surfaces. All cats in the three heartworm-infected groups had live heartworms and the typical pulmonary arterial changes of heartworm disease at necropsy. The arterial surfaces, as viewed with scanning electron microscopy, had villus proliferations that were more numerous and exuberant than similar infections in dogs. Mean percentage of arterial surface involvement with villus proliferation of the nontreated heartworm infected cats was 67.3%; the aspirin treated cats, 73.8%; and the adjusted aspirin treated cats, 75.9%. The villi were myointimal proliferations in the small and medium-sized arteries. The more elastic arteries had a predominance of fibromuscular proliferation. All heartworm infected cats had arterial muscular hypertrophy of the small arteries, in contrast to only three of eight of the nonheartworm infected cats. The caudal lobar arteries were frequently obstructed with either villus proliferation, thrombi, and/or dead heartworms. The muscular arteries had branches with marked dilation, a condition associated with pulmonary hypertension in man. However, only three cats, one in each group, had pulmonary hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: C A
authors.initials: CA
authors.lastname: Rawlings
authors.forename: R L
authors.initials: RL
authors.lastname: Farrell
authors.forename: R M
authors.initials: RM
authors.lastname: Mahood
mesh_terms: D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy / Q000473:pathology*; D002415:Cats; D004183:Dirofilaria immitis / Q000302:isolation & purification; D004184:Dirofilariasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008168:Lung / Q000469:parasitology / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000473:pathology / Q000648:ultrastructure; D011651:Pulmonary Artery / Q000469:parasitology / Q000648:ultrastructure*
chemical_list: D001241:Aspirin