The effect of physical activity on the incidence of circulating platelet aggregates in healthy persons. The significance for antiaggregating therapy.
In 23 healthy persons active in sports are tested circulating thrombocyte aggregates in venous blood. Their incidence is expressed as thrombocyte index (TI). In this group there is TI 0.8900 +/- 0.0193. TI compared with TI evaluated in 21 healthy persons not interested in their physical fitness (TI 0.7699 +/- 0.0162) is significantly different (p less than 0.01). The physically not active persons develop significant (p less than 0.01) higher incidence of circulating thrombocyte aggregates in comparison with the incidence in group of physically active persons. The authors use TI for monitoring antiaggregant therapy and for selection the risk group of patients, whose clinical situation requires antiaggregant treatment. The dosage of antiplatelet drugs is estimated according TI values to reach the level recorded in healthy physically active persons (TI greater than 0.7699 +/- 0.0162).
Dosková
M
M
IV Medical Department, University Hospital, Charles University, Prague, Czechoslovakia.
Hrabák
P
P
Puchmayer
V
V
Albrecht
V
V
D000328:Adult; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D010976:Platelet Count; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000517:prevention & control*
D010975:Platelet Aggregation Inhibitors