Constituents of the seed of Malva verticillata. VI. Characterization and immunological activities of a novel acidic polysaccharide.
A novel acidic polysaccharide, designated as MVS-VI, was isolated from the seeds of Malva verticillata L. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 26000. It is composed of L-arabinose: D-xylose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 30: 15: 20: 3: 2: 10, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated its structural features to have mainly acidic alpha-arabino-3,6-beta-galactan type structural units. MVS-VI showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, and it possesses remarkable anti-complementary activity.
Gonda
R
R
Kyoritsu College of Pharmacy, Tokyo, Japan.
Tomoda
M
M
Kanari
M
M
Shimizu
N
N
Yamada
H
H
D000328:Adult; D000818:Animals; D003169:Complement Inactivator Proteins; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents; D051379:Mice; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry* / Q000276:immunology / Q000494:pharmacology; D012756:Sheep / Q000276:immunology
D003169:Complement Inactivator Proteins; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D011134:Polysaccharides