Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety.
The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 A and 102 kDa, respectively, down to a concentration of 2.0 x 10(-5) M.
Sonnino
S
S
Department of Medical Chemistry and Biochemistry, Medical School, University of Milan, Italy.
Cantu
L
L
Corti
M
M
Acquotti
D
D
Kirschner
G
G
Tettamanti
G
G
D000107:Acetylation; D002240:Carbohydrate Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005677:G(M1) Ganglioside / Q000737:chemistry*; D008027:Light; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012542:Scattering, Radiation; D013500:Surface Tension
D046911:Macromolecular Substances; D008823:Micelles; D005677:G(M1) Ganglioside