title: [Protective effect of a calcium antagonist against renal vasoconstriction induced by endothelin in the normotensive rat].
abstract: We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.
authors.affiliation: Centro Ipertensione, Università di Sassari.
authors.forename: P
authors.initials: P
authors.lastname: Madeddu
authors.forename: F
authors.initials: F
authors.lastname: Pala
authors.forename: C
authors.initials: C
authors.lastname: Troffa
authors.forename: P
authors.initials: P
authors.lastname: Pinna Parpaglia
authors.forename: A
authors.initials: A
authors.lastname: Pazzola
authors.forename: A
authors.initials: A
authors.lastname: Soro
authors.forename: P
authors.initials: P
authors.lastname: Manunta
authors.forename: G
authors.initials: G
authors.lastname: Tonolo
authors.forename: M G
authors.initials: MG
authors.lastname: Melis
authors.forename: M P
authors.initials: MP
authors.lastname: Demontis
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D016232:Endothelins; D009543:Nifedipine
vernacular_title: Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.