title: Production of large-scale peptides in solution.
abstract: The production of large-scale peptides in solution has some advantages and some disadvantages. Advantages. (i) The layout of the synthesis can be planned in advance in respect of: main- and side-chain protection; fragment selection and methods of fragment coupling to minimize racemization. (ii) In production: purification, at best crystallization, of the intermediates; scale-up potential; analysis can be performed at each step and analytical criteria defined and different fragments can be produced at the same time. Disadvantages. There are a number of problems: solubility of the intermediates; limited scale-up potential; introduction of processes into production in an immature state; process-streamlining over several years; long-time requirement for the synthesis, which depends on the reactors that are available and the most time-consuming path of the synthesis and the demands of the market cannot be met on short notice.
authors.affiliation: Ciba-Geigy Ltd, Basle, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Gorup
mesh_terms: D000595:Amino Acid Sequence; D000802:Angiotensin Amide / Q000138:chemical synthesis / Q000737:chemistry; D002116:Calcitonin / Q000138:chemical synthesis / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D003366:Cosyntropin / Q000138:chemical synthesis / Q000737:chemistry; D006728:Hormones / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions
chemical_list: D006728:Hormones; D010455:Peptides; D012996:Solutions; D003366:Cosyntropin; D000802:Angiotensin Amide; D002116:Calcitonin