Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?
The neurovirulent strain of vaccinia virus, VV-WR, or recombinants derived from VV-WR, cause highly productive infection of murine ovaries, but infection could be partially inhibited in vivo using an antiserum to asialo-GM1 (as-GM1). In vitro analysis by flow cytometry revealed that murine ovarian cells expressed a cell surface antigen identical to or cross-reactive with as-GM1. The capacity of VV-WR to infect murine ovaries appears to depend in part upon as-GM1 expression on ovarian cells.
Karupiah
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Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
Blanden
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RV
D000818:Animals; D000906:Antibodies / Q000502:physiology; D037263:Asialoglycoprotein Receptor; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D010053:Ovary / Q000382:microbiology; D011971:Receptors, Immunologic / Q000276:immunology; D014615:Vaccinia / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology; D014779:Virus Replication
D000906:Antibodies; D037263:Asialoglycoprotein Receptor; D006028:Glycosphingolipids; D011971:Receptors, Immunologic; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside