The influence of zinc administration on the development of experimental lung metastases after an injection of tumour cells into the tail vein of rats.
Rats having received drinking water enriched with zinc (zinc acetate, 22.8 mmol/l) developed significantly more pulmonal metastases after an i.v. injection of 5 x 10(5) cultivated cells of a benzpyrene-induced sarcoma than receiving normal drinking water. Zinc ions seem to promote the emigration, implantation and outgrowth of circulating tumour cells.
Rath
F W
FW
Institute of Pathology, Martin Luther University Halle-Wittenberg, FRG.
Körtge
R
R
Haase
P
P
Bismarck
M
M
D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000556:secondary*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000473:pathology / Q000556:secondary*; D013623:Tail / Q000098:blood supply; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
D015032:Zinc