[Isolation and characteristics of rifampicin-resistant mutants of Streptomyces erythraeus strain].
Erythromycin-producing strains of S. erythraeus were characterized with respect to formation of spontaneous and induced rifampicin-resistant mutants. It was shown that the frequency of spontaneous rifampicin-resistant mutants formed by various strains amounted to 0.9.10(-8) = 9.1.10(-7). In some events the exposure to nitrosoguanidine increased the frequency of such mutants by 2 orders of magnitude. The rifampicin-resistant mutants differed in antibiotic resistance. It was found that a significant part of the rifampicin-resistant mutants became sensitive to heating (19.1 per cent) and lost the ability to form aeromycelium (21.8 per cent).
Nastasiak
I N
IN
Fedorenko
V A
VA
Kirichenko
N V
NV
Danilenko
V N
VN
D003470:Culture Media; D004352:Drug Resistance, Microbial / Q000235:genetics; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests / Q000379:methods; D009154:Mutation / Q000187:drug effects / Q000235:genetics*; D012293:Rifampin / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
D003470:Culture Media; D012293:Rifampin
Poluchenie i kharakteristika rifampitsinoustoĭchivykh mutantov u shtamma Streptomyces erythraeus.