Reactive potential of diethylstilbestrol reactive metabolites towards cellular nuclear proteins: implications for estrogen-induced carcinogenesis.
Roy
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Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
D000818:Animals; D001711:Biotransformation; D002868:Chromosomal Proteins, Non-Histone / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D006657:Histones / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009687:Nuclear Proteins / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D009687:Nuclear Proteins; D013438:Sulfhydryl Compounds; D009249:NADP; D004054:Diethylstilbestrol