Synthesis, characterization, and DNA binding studies of some mixed-ligand platinum(II) complexes of 1,10-phenanthroline and amino acids.
A series of complexes of the type [Pt(phen)(AA)]+ (where AA is the anion of glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, or L-tryptophan) has been synthesized. These complexes have been characterized by electronic absorption, infrared, and 1H NMR spectroscopy. The interaction of these complexes with calf thymus DNA has been studied using fluorescence spectroscopy. They inhibit the intercalation of ethidium bromide in DNA by intercalative binding at low concentrations and show nonintercalative binding at higher concentrations.
Mital
R
R
Department of Chemistry, Indian Institute of Technology, Bombay.
Srivastava
T S
TS
D000409:Alanine; D000596:Amino Acids; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D002417:Cattle; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004247:DNA / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism; D005998:Glycine; D007364:Intercalating Agents; D007930:Leucine; D009682:Magnetic Resonance Spectroscopy; D010618:Phenanthrolines; D010649:Phenylalanine; D010984:Platinum; D013050:Spectrometry, Fluorescence; D014364:Tryptophan; D014443:Tyrosine
D000596:Amino Acids; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D010618:Phenanthrolines; D014443:Tyrosine; D010649:Phenylalanine; D010984:Platinum; D014364:Tryptophan; D004247:DNA; D004996:Ethidium; D007930:Leucine; D000409:Alanine; D002945:Cisplatin; D005998:Glycine; C025205:1,10-phenanthroline