title: [The effect of physical training on the indices of the general hemodynamics and kinin-kallikrein system activity in hypertension patients].
abstract: Forty men aged 30-60 years suffering from stage-II essential hypertension were examined for the general hemodynamics, the level of prekallikrein (PK) and kallikrein-like activity (KLA) of blood plasma, and kallikrein excretion with urine. The examinations were made before and after 30 weeks of exercise. Before such a course of exercise the response of the cardiovascular system and of the kinin-kallikrein system (KKS) to exercise was characterized by a significant rise of systolic, diastolic medium-hemodynamic arterial pressure, heart rate and kallikrein excretion with urine together with the lack changes in PK and KLA of blood plasma. No correlations were established between the KKS, which is likely to be determined by the disease. After the course of exercise there was a significant reduction of all the initial characteristics of the general hemodynamics, KLA, a close to significant increase of the PK level and a well-defined tendency towards lowering of kallikrein excretion with urine, and less remarkable response of all the parameters of both systems to standard exercise. A reverse correlation (r = -0.57) was established between the PK level and KLA at rest which may attest to a positive influence of exercise on the recovery of the correlations between the parameters of the KKS.
authors.forename: G V
authors.initials: GV
authors.lastname: Fomenko
authors.forename: V A
authors.initials: VA
authors.lastname: Kuznetsov
authors.forename: L F
authors.initials: LF
authors.lastname: Nikolaeva
authors.forename: T D
authors.initials: TD
authors.lastname: Bol'shakova
authors.forename: G G
authors.initials: GG
authors.lastname: Arabidze
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005080:Exercise Test; D005081:Exercise Therapy; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis; D013997:Time Factors
chemical_list: D011288:Prekallikrein; D007610:Kallikreins
vernacular_title: Vliianie fizicheskikh trenirovok na pokazateli obshcheĭ gemodinamiki i aktivnosti kinin-kallikreinovoĭ sistemy u bol'nykh gipertonicheskoĭ bolezn'iu.