[L-pyroglutamyl-D-alanine amide normalizes the function of the developing brain damaged by antenatal alcoholization in rats].
The effects of the synthetic dipeptide, L-pyroglutamyl-D-alaninamide (LPDA) were studied in the experiments on offspring of alcoholized during the pregnancy (5 g/kg/day) females. This dipeptide, which revealed the nootropic activity in previous experiments, was injected to the pups in dose of 1 mg/kg from 8 to 19 days of life. LPDA was shown to prevent the delayed disturbances of learning in passive avoidance test, of extrapolatory behaviour in escape test, to attenuate the emotional hyperreactivity. LPDA normalized EEG power spectrum, decreased interhemispheric asymmetry. This substance attenuated the disbalance evoked by prenatal alcoholization.
Ostrovskaia
R U
RU
Trofimov
S S
SS
Gudasheva
T A
TA
Smol'nikova
N M
NM
Nemova
E P
EP
Krapivin
S V
SV
Savchenko
N M
NM
Tsirenina
M L
ML
Ushakov
A N
AN
Mel'nik
E I
EI
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000188:drug therapy*; D007859:Learning Disabilities / Q000517:prevention & control; D011247:Pregnancy; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats
D004151:Dipeptides; C060738:L-pyroglutamyl-L-alanine; D011761:Pyrrolidonecarboxylic Acid
Normalizatsiia amido L-piroglutamil-D-alanina funktsiĭ razvivaiushchegosia mozga, narushennykh antenatal'noĭ alkogolizatsieĭ krys.