title: End-stage avascular necrosis of bone in renal transplant patients. The natural history.
abstract: We report the results of conservative treatment of stage III and stage IV avascular necrosis of bone (AVN) affecting the hip or knee in renal transplant patients. Twenty-nine patients were followed for a mean period of five years. Conservative management was successful in controlling symptoms in 40% of those with AVN of the hip and in 70% of those with AVN of the knee. Knowledge of the natural history of AVN is important because of the long survival times after renal transplantation.
authors.affiliation: United Medical School, Guy's Hospital, London, England.
authors.forename: M A
authors.initials: MA
authors.lastname: Churchill
authors.forename: J D
authors.initials: JD
authors.lastname: Spencer
mesh_terms: D000328:Adult; D000368:Aged; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D005271:Femur Head Necrosis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D005500:Follow-Up Studies; D006622:Hip Prosthesis / Q000592:standards; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D007719:Knee Joint; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D010027:Osteotomy / Q000592:standards
chemical_list: D003524:Cyclosporins