[The modification of the catalytic activity of mitochondrial monoaminoxidase and the suppression of the growth of experimental brain tumors].
A derivative of pyrazinocarbazole the antidepressant pyrazidol, whose inhibition of serotonin deaminase activity of the brain mitochondrial monoamine oxidase is attended by induction of the property of catalysing histamine oxidation, inhibits the growth of glial tumors in experiments. Another derivative of pyrazinocarbazole, which inhibits serotonin deamination but does not induce the appearance of histamine deaminase activity, produces no effect on the growth of glial tumors of the brain.
Baumanis
E A
EA
Gorkin
V Z
VZ
Lisianyĭ
N I
NI
Kozhukhov
A N
AN
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy* / Q000201:enzymology; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D002227:Carbazoles / Q000627:therapeutic use; D002384:Catalysis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy* / Q000201:enzymology; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D008995:Monoamine Oxidase / Q000187:drug effects* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; C067315:3,3a-dehydropyrazidol; D008995:Monoamine Oxidase; C009830:pirlindole
Modifikatsiia kataliticheskoĭ aktivnosti mitokhondrial'noĭ monoaminoksidazy i ugnetenie rosta éksperimental'nykh opukholeĭ golovnogo mozga.