Sympathoadrenal activity and hypoglycemia in the hibernating garden dormouse.
The hibernating garden dormouse is spontaneously hypophagic during the prehibernating period at which time we found a low peripheral sympathetic activity (S.A.). The aim of this work was to investigate the link between dietary intake and S.A. The S.A. was evaluated by measurement of catecholamines in both plasma and adrenal glands by HPLC. Food intake, body weight, energy expenditure and plasma glucose were measured during the reentry phase of the hibernating period. The following results were obtained: the energy intake in pretorpid animals (55 to 83 kJ/24 h/100 g body weight) was less than energy expenditure which was between 145 and 97 kJ/24 h/100 g. The energy deficit induces marked hypoglycemia immediately before the onset of hypothermia (117 mg/dl vs. 76 mg/dl) and leads to a drastic drop in the peripheral sympathetic system. This, in turn, reduced energy production, causing the hypothermia.
Atgie
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C
Laboratoire des Régulations des Métabolismes et Nutrition, Université Paul Sabatier, Toulouse, France.
Nibbelink
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Ambid
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D000311:Adrenal Glands / Q000294:innervation*; D000313:Adrenal Medulla / Q000294:innervation; D000818:Animals; D001143:Arousal / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D006605:Hibernation / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood; D012377:Rodentia / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine; D004837:Epinephrine