title: Prognostic factors of alveolar rhabdomyosarcoma in childhood. An International Society of Pediatric Oncology study.
abstract: Pretreatment characteristics of 57 patients with alveolar rhabdomyosarcoma (RMS) registered by the International Society of Pediatric Oncology (SIOP) between January 1975 and December 1983 were identified to perform a prognostic factor study. Living status and disease-free survival (DFS) time were assessed for all patients on January 1, 1988. By multi-variate analyses, lymph node involvement (P = 0.0003) and tumor invasiveness (P = 0.007) were identified as the most significant covariates correlated with survival. A model including N stage (P = 0.001) and age (P = 0.03) was selected for predicting DFS rates. Children between 5 and 10 years of age had better DFS rates than those younger than 5 years of age or those older than 10 years of age. The authors suggest a prognostic classification that could allow treatment to be adjusted according to clinical staging.
authors.affiliation: Unité de Biostatisques Institut Curie Roussy, France.
authors.forename: J
authors.initials: J
authors.lastname: Reboul-Marty
authors.forename: E
authors.initials: E
authors.lastname: Quintana
authors.forename: V
authors.initials: V
authors.lastname: Mosseri
authors.forename: F
authors.initials: F
authors.lastname: Flamant
authors.forename: B
authors.initials: B
authors.lastname: Asselain
authors.forename: C
authors.initials: C
authors.lastname: Rodary
authors.forename: J M
authors.initials: JM
authors.lastname: Zucker
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010372:Pediatrics; D011379:Prognosis; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis