title: 17 beta estradiol affects the expression of guinea pig blood leukocyte MHC antigens.
abstract: Sex hormones have an effect on various immune responses but the mechanisms of action are unknown. One of these mechanisms might be a modification of expression of major histocompatibility complex (MHC) antigens in blood leucocytes. Estradiol-induced variations of the expression of guinea pig blood leukocytes MHC antigens (GPL-A) was studied. Class I and class II MHC antigens were detected by a sensitive rosetting method using specific alloimmune sera (AIS) and staphylococcal protein A-coated sheep red blood cells (SPA-SRBC) and evaluated by counting the number of bound SPA-SRBC per 100 cells. MHC antigens decreased after estrogen treatment. Estradiol modifies the expression of GPL-A antigens on the mononuclear cells including the Kurloff cells, which are involved in immunity or in a natural killer effect, but did not affect the expression of polymorphonuclear cells, ones which are not involved in immunity.
authors.affiliation: Laboratoire d'Histologie, U. F. R. de Médecine, C.H.U. Côte de Nacre, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Debout
authors.forename: M
authors.initials: M
authors.lastname: Lefroit-Joliy
authors.forename: T
authors.initials: T
authors.lastname: Neveu
authors.forename: J
authors.initials: J
authors.lastname: Izard
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D012397:Rosette Formation; D013205:Staphylococcal Protein A
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D013205:Staphylococcal Protein A; D004958:Estradiol