title: Hemoglobin H disease complicated iron overload and HLA expression in Chinese.
abstract: HLA-A,B antigens were typed in 15 patients with Hemoglobin H disease; 10 of them had iron overloading. No significant HLA antigen specificity was identified to be at risk as compared with 170 controls. However, HLA-A11 was suggested to have significant negative risk, and may have a protective effect. (RR = 0.1, p = 0.0015). It seems that increased iron absorption in Hemoglobin H disease is not genetically associated with idiopathic hemochromatosis and certain HLA antigen expressions.
authors.affiliation: Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: M P
authors.initials: MP
authors.lastname: Chow
authors.forename: H C
authors.initials: HC
authors.lastname: Hsu
authors.forename: C H
authors.initials: CH
authors.lastname: Yung
authors.forename: W K
authors.initials: WK
authors.lastname: Chau
authors.forename: H W
authors.initials: HW
authors.lastname: Peng
authors.forename: S H
authors.initials: SH
authors.lastname: Tsay
authors.forename: E
authors.initials: E
authors.lastname: Tse
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D015234:HLA-A Antigens / Q000378:metabolism; D015235:HLA-B Antigens / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012306:Risk; D013624:Taiwan; D013789:Thalassemia / Q000276:immunology / Q000378:metabolism*
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D007501:Iron