Hydantoin derivatives. A new class of inhibitors of human leukocyte elastase.
Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly. Chymotrypsin and cathepsin G are also inhibited by these compounds.
Groutas
W C
WC
Department of Chemistry, Wichita State University, KS 67208.
Stanga
M A
MA
Castrisos
J C
JC
Schatz
E J
EJ
D000595:Amino Acid Sequence; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D007700:Kinetics; D007962:Leukocytes / Q000201:enzymology*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood*; D011480:Protease Inhibitors / Q000138:chemical synthesis*
D006827:Hydantoins; D007202:Indicators and Reagents; D009842:Oligopeptides; D011480:Protease Inhibitors; D010196:Pancreatic Elastase