Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion.
Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400 micrograms/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.
Kohli-Kumar
M
M
Children's Hospital Medical Center, Cincinnati, OH.
Pearson
A D
AD
Sharkey
I
I
Craft
A W
AW
D002675:Child, Preschool; D004421:Dystonia / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000009:adverse effects*; D011352:Procyclidine / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D016055:Urinary Retention / Q000139:chemically induced*
D011352:Procyclidine; D008787:Metoclopramide