title: Influence of muramyl dipeptide on established experimental arthritis in rats.
abstract: The effects of MDP, a potent inducer of cytokines, were studied in four batches of Wistar Furth rats with established experimental arthritis. Arthritic rats were given a daily sc injection of 10, 100, 200 or 400 micrograms MDP respectively. Muramyl dipeptide increased the severity of clinical events in a dose-dependent manner, with the exception of the 10 micrograms dose which was ineffective. The levels of anti-collagen antibodies were not however significantly enhanced by MDP. Radiological lesions and histological changes were maximal at high dosage regimens. Paradoxically, the acute phase reactive alpha 1 glycoprotein was little affected by MDP treatment.
authors.affiliation: Department of Pharmacology, URA CNRS 1288, Nancy.
authors.forename: J Y
authors.initials: JY
authors.lastname: Jouzeau
authors.forename: E
authors.initials: E
authors.lastname: Drelon
authors.forename: P
authors.initials: P
authors.lastname: Gillet
authors.forename: B
authors.initials: B
authors.lastname: Bannwarth
authors.forename: P
authors.initials: P
authors.lastname: Fener
authors.forename: G
authors.initials: G
authors.lastname: Charrière
authors.forename: E
authors.initials: E
authors.lastname: Payan
authors.forename: L
authors.initials: L
authors.lastname: Chauvelot-Moachon
authors.forename: A M
authors.initials: AM
authors.lastname: Batt
authors.forename: J
authors.initials: J
authors.lastname: Floquet
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D011859:Radiography; D051381:Rats; D011920:Rats, Inbred WF
chemical_list: D006023:Glycoproteins; D007074:Immunoglobulin G; D000119:Acetylmuramyl-Alanyl-Isoglutamine