title: Improved heart and lung preservation in a rat model.
abstract: We investigated the efficacy of four different preservation solutions in a heart-lung model in the rat. The heart and lungs of the donor were perfused under standardised conditions of temperature, pressure and flow. We studied 4 groups: group 1 received Stanford solution to heart and lung; group 2 received St. Thomas' solution to heart and Papworth solution to lung; group 3 received University of Wisconsin solution to heart and lung; and group 4 received University of Wisconsin solution to heart and Papworth solution to lung. Lung function assessed by arterial pO2 at a standardised FIO2 was significantly better in groups 2 and 4 than in other groups. However, cardiac function as assessed by cardiac output, stroke work index and minute work index was significantly better in group 4 than in any other group. Overall, the combination of solutions in group 4 provided the most effective preservation in this model.
authors.affiliation: Department of Cardiothoracic Surgery, St. George's Hospital Medical School, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Reader
authors.forename: J
authors.initials: J
authors.lastname: Hynd
authors.forename: J
authors.initials: J
authors.lastname: Pepper
mesh_terms: D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D005978:Glutathione; D016041:Heart-Lung Transplantation / Q000379:methods* / Q000502:physiology; D007328:Insulin; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011887:Raffinose; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions
chemical_list: D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose