The induction of cytochrome P-450-IA1 in juvenile fish by creosote-contaminated sediment.
Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.
Schoor
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WP
U.S. Environmental Protection Agency, Environmental Research Laboratory, Gulf Breeze, Florida 32561.
Williams
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DE
Takahashi
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N
D000818:Animals; D003407:Creosote / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004781:Environmental Exposure; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011036:Poecilia / Q000378:metabolism*; D012989:Soil Pollutants / Q000633:toxicity*
D012989:Soil Pollutants; D003407:Creosote; D003577:Cytochrome P-450 Enzyme System