Tidal peritoneal dialysis with racemic or L-lactate solutions.
To see if rapid lactate absorption on tidal peritoneal dialysis (TPD) would overwhelm D-lactate metabolism using racemic lactate and/or L-lactate metabolism using all L-lactate, five patients underwent 8-h TPD treatments with racemic lactate solution one day and with L-lactate another. Lactate concentrations (total) were 40 mmole/L, flow rates 27.3 L/8 h, tidal and reservoir volumes each 1.5L, tidal cycles 24-26 min, and net ultrafiltration per tidal cycle 70 to 99 mL.


RESULTS
Mean absorptions of D and L-lactate were 24.2 and 25.1%, respectively, compared to glucose at 14.6%. Urea clearances averaged 21.4 mL/min. Mean blood D-lactates at baseline were 0.6 +/- 0.5 SD mmole/L and after 8 h of TPD were 0.6 +/- 0.4 and 0.7 +/- 0.3 using L-lactate and racemic solutions, respectively; similar values for L-lactate were 1.2 +/- 0.3 at baseline and 1.2 +/- 0.3 and 1.2 +/- 0.5 after 8 h with L-lactate and racemic solutions. delta blood pH values were + 0.02 +/- 0.01 and + 0.04 +/- 0.03, while delta bicarbonate values were + 1.7 +/- 0.9 and + 0.7 +/- 1.0 for the all L and racemic studies, respectively. The total mmoles of L-lactate absorbed per 8 h of TPD with all L solution (greater than 300 mmoles) are greater than ever reported for peritoneal dialysis, but did not increase blood lactate levels. It would seem that either type of solution is suitable for TPD. Absorptions and metabolic rates are similar for L-Lactate and D-Lactate.
Nolph
K D
KD
Department of Medicine, University of Missouri Health Sciences Center, Columbia 65212.
Twardowski
Z J
ZJ
Khanna
R
R
Prowant
B F
BF
Ponferrada
L P
LP
Schmidt
L M
LM
Moore
H L
HL
D000328:Adult; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005069:Evaluation Studies as Topic; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D007773:Lactates / Q000493:pharmacokinetics*; D019344:Lactic Acid; D010530:Peritoneal Dialysis / Q000379:methods*; D010537:Peritoneum / Q000502:physiology
D015314:Dialysis Solutions; D007773:Lactates; D019344:Lactic Acid