Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey.
The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260 at doses of 100 ng/kg to 100 micrograms/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates.
O'Neill
M F
MF
Merck Sharp and Dohme Research Laboratory, Neuroscience Research Centre, Harlow, Essex U.K.
Dourish
C T
CT
Tye
S J
SJ
Iversen
S D
SD
D000698:Analgesia; D000818:Animals; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D010146:Pain / Q000503:physiopathology; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin / Q000187:drug effects* / Q000502:physiology; D012453:Saimiri; D013997:Time Factors
D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260; D002766:Cholecystokinin