[Combination effects of fosfomycin and other oral antimicrobial agents against methicillin-resistant Staphylococcus aureus].
Combination effects of fosfomycin (FOM) and other oral antimicrobial agents were studied against methicillin-resistant Staphylococcus aureus (MRSA) (methicillin: minimal inhibitory concentration (MIC) greater than or equal to 12.5 micrograms/ml) isolated from skin and skin structure infections. The fractional inhibitory concentration (FIC) index equal to or less than 0.5 was seen in 63.0% of 27 MRSA strains for FOM and minocycline combination, in 44.4% for FOM and cefatrizine, in 44.4% for FOM and cefaclor, in 40.7% for FOM and cefalexin, in 37.0% for FOM and doxycycline, in 29.6% for FOM and erythromycin, in 22.2% for FOM and rokitamycin, in 18.5% for FOM and ofloxacin, in 14.8% for FOM and sultamicillin, in 11.1% for FOM and clavulanic acid/amoxicillin. The combination effects of FOM and minocyclin, or FOM and cephalosporins were higher than other combinations with FOM. Combination of FOM with other antibiotics could be a useful way to treat MRSA skin and skin structure infections.
Akiyama
H
H
Department of Dermatology, Okayama University Medical School.
Yamada
T
T
Shimoe
K
K
Torigoe
R
R
Kanzaki
H
H
Arata
J
J
D000284:Administration, Oral; D002511:Cephalosporins / Q000008:administration & dosage / Q000494:pharmacology; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000494:pharmacology; D004917:Erythromycin / Q000008:administration & dosage / Q000494:pharmacology; D005578:Fosfomycin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D016106:Methicillin Resistance; D008911:Minocycline / Q000008:administration & dosage / Q000494:pharmacology; D012867:Skin / Q000382:microbiology*; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D002511:Cephalosporins; D005578:Fosfomycin; D004917:Erythromycin; D008911:Minocycline; D004318:Doxycycline