Potentiation of cisplatin lethality by bacterial lipopolysaccharide pretreatment in mice.
The present study was designed to determine whether bacterial endotoxin (LPS) affects the lethality of cisplatin. Mice treated with LPS (1 mg/kg, i.p.) 24 hr and 1 hr before cisplatin had markedly increased the lethality and nephrotoxicity of cisplatin.
Ishikawa
M
M
Department of Pharmacology & Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ohzeki
R
R
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011292:Premedication
D004731:Endotoxins; D008070:Lipopolysaccharides; D002945:Cisplatin