title: Photoprotective effect of topical anti-inflammatory agents against ultraviolet radiation-induced chronic skin damage in the hairless mouse.
abstract: Albino hairless mice (Skh:HR-1) exposed chronically to suberythemal doses of ultraviolet (UV) radiation display visible and histological alterations in the skin. One alteration is an increase in dermal cellularity, including inflammatory cells. This suggested a role for inflammation in chronic photodamage. We evaluated the photoprotective effect of topical hydrocortisone, ibuprofen, and naproxen against photodamage. All 3 agents protected against UVB radiation-induced visible wrinkling, tumor formation, and histological alterations. Hydrocortisone and naproxen were also evaluated for protection against UVA radiation-induced visible skin sagging and histological alterations. Both were very effective. These data indicate that chronic topical application of anti-inflammatory agents provides broad solar UV spectrum photoprotection.
authors.affiliation: Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
authors.forename: D L
authors.initials: DL
authors.lastname: Bissett
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
authors.forename: D P
authors.initials: DP
authors.lastname: Hannon
mesh_terms: D000279:Administration, Cutaneous; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D008812:Mice, Hairless; D009288:Naproxen / Q000008:administration & dosage / Q000627:therapeutic use; D010787:Photosensitivity Disorders / Q000517:prevention & control*; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D009288:Naproxen; D006854:Hydrocortisone; D007052:Ibuprofen