title: Evaluation of renal function before and after intravenous injection of non-cholangiographic water soluble contrast media in rats: preliminary results.
abstract: In this preliminary study, water soluble contrast media (CM) were administrated to normal laboratory rats (n = 11) and renal function was monitored before and followed after this challenge. A significant decrease (p less than or equal to 0.001) of the absolute urinary creatinine output, was noted during 3 days after the injection of the CM: the median (M) control value was 0.0313 mumol/min. 100 g body weight (BW) (interquartile range (IR): 0.0014) while the M values the first, the second and the third day were 0.0209 mumol/min. 100 g BW (IR: 0.0141), 0.0198 mumol/min. 100 g BW (IR: 0.0044) and 0.0265 mumol/min. 100 g BW (IR: 0.0054) respectively. The serum creatinine 24 hours after injection was 59,8 mumol/l (IR: 7.92) which is significantly higher (p less than or equal to 0.002) compared to the M serum creatinine of 51.9 mumol/l (IR: 15.0) evaluated in a group of normal unchallenged laboratory rats. These changes are in contrast with the low frequency of renal failure episodes encountered in clinical circumstances. Further experiments with inclusion of a control group receiving a sham injection seem necessary.
authors.affiliation: University Hospital, Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Verbaeys
authors.forename: N
authors.initials: N
authors.lastname: Lameire
authors.forename: D
authors.initials: D
authors.lastname: Kesteloot
authors.forename: M
authors.initials: M
authors.lastname: Waterloos
authors.forename: G
authors.initials: G
authors.lastname: Van Maele
authors.forename: S
authors.initials: S
authors.lastname: Ringoir
authors.forename: W
authors.initials: W
authors.lastname: De Sy
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000032:analysis*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000009:adverse effects; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014567:Urography
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; C002587:ioxitalamic acid; D003404:Creatinine; D007485:Ioxaglic Acid