[The antishock action of opiate antagonists].
In acute experiment on 86 adult rabbits with traumatic shock modelled according to Cannon, it was established that intravenous administration of Nalorphine at the doses of 0.5 and 2 mg/kg of weight at the early period of shock contributed to prolongation of lifetime of the majority of animals. In some of them, the small doses accelerated the occurrence of lethal outcome. In administration of 0.1 mg/kg of weight of Naloxone, almost all the animals survived. At the late period of shock, the effectiveness of these preparations is insufficient.
Sherman
D M
DM
Mikuliak
I V
IV
D000818:Animals; D009269:Nalorphine / Q000627:therapeutic use*; D009270:Naloxone / Q000627:therapeutic use*; D011817:Rabbits; D012774:Shock, Traumatic / Q000188:drug therapy*
D009270:Naloxone; D009269:Nalorphine
Protivoshokovoe deĭstvie antagonistov opiatov.