Extensive spontaneous occlusive arteriosclerosis of the lingual arteries in Fischer rats, a model for the study of human occlusive arteriosclerosis of medium- and small-sized arteries.
Spontaneous occlusive arteriosclerosis is rarely present in rats or other laboratory rodents. Instead, the common vascular lesion in these animals is a mineralization resembling Mönkeberg's medial calcinosis, or non-atheromatous and non-obstructive arteriosclerosis. For reasons yet unknown, the lingual arteries of Fischer rats behave differently; they develop extensive sclerotic lesions with progressive narrowing of the lumen, leading to complete occlusion and sometimes recanalization, comparable to lesions seen in human coronaries, carotids, tibials, etc. The spontaneous plaque-forming, thrombotic, occlusive arteriosclerosis of the lingual artery in Fischer rats can serve as an experimental model for the same lesion of medium- and small-sized arteries in man. As such, it can considerably facilitate the testing of nutritional, hormonal, immunological and other chemical or physical factors for a possible role in promoting or inhibiting the thrombotic-occlusive arteriopathy in man.
Rivenson
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American Health Foundation, Valhalla, New York 10595.
Hoffmann
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D
D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000473:pathology; D001167:Arteritis / Q000473:pathology; D004195:Disease Models, Animal; D015726:Giant Cells / Q000473:pathology; D008297:Male; D009538:Nicotine / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D014059:Tongue / Q000098:blood supply* / Q000473:pathology
D009538:Nicotine