Effect of propranolol on endothelin-induced increase in cytosolic free calcium.
This study was designed to investigate the effect of propranolol on endothelin (ET)-1-induced increase in cytosolic Ca2+ [( CA2+]i) in cultured vascular smooth muscle cells (VSMCs) obtained from rat aorta. Propranolol (0.01 to 1 mmol/L) reduced the changes in the initial transient and the later sustained phase of [Ca2+]i induced by 100 nmol/L ET-1 as well as 10 mmol/L procaine. The inhibitory action of propranolol on the change in [Ca2+]i induced by ET-1 may be involved in one of the mechanisms of propranolol-induced reduction of vasospasms.
Yokokawa
K
K
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Murakawa
K
K
Yasunari
K
K
Kohno
M
M
Inoue
T
T
Takeda
T
T
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003329:Coronary Vasospasm / Q000209:etiology; D003600:Cytosol / Q000378:metabolism; D016232:Endothelins / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D011343:Procaine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*
D016232:Endothelins; D011343:Procaine; D011433:Propranolol; D002118:Calcium