Effect of testosterone on adrenal corticosteroidogenesis in lithium treated male rats.
Lithium chloride at a dose of 200 micrograms/100 g body weight/day given for 21 days caused a significant increase in adrenal weight, adrenal 5-ene-3 beta-hydroxysteroid dehydrogenase (5-ene-3 beta-HSD) activity along with elevation in serum level of corticosterone on the 22nd day in the rat. Administration of testosterone for the last 14 days to lithium treated rats caused a significant decrease in adrenal weight, adrenal 5-ene-3 beta-HSD activity and serum level of corticosterone in comparison to lithium treated animals.
Ghosh
D
D
Department of Physiology, University College of Science, Calcutta, India.
Biswas
N M
NM
Chaudhuri
A
A
Ghosh
P K
PK
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D013739:Testosterone; D008094:Lithium; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; D003345:Corticosterone