title: Auditory stimulus intensity gradients and response to methylphenidate in ADD children.
abstract: Using an auditory stimulus intensity paradigm, we obtained both event related potentials (ERPs) and press and release reaction times (RT) from a large sample of children with Attention Deficit Disorder (ADD). The ERP gradients to three tone intensities were used to classify the children as augmenters (steep gradients), moderates, or reducers (shallow or negative gradients). The RT data were used to classify the children as strong or sensitive, following neo-Pavlovian guidelines. The children were then cross-classified on these two dimensions and compared on cognitive, behavioral, and performance measures. The groups were also compared in response to two dosage levels of methylphenidate. Based on prior studies, we hypothesized that: 1. ERP augmenters would respond as well to the low as high dose but that reducers would respond better to high than low dose; and II. sensitive types (RT measure) would do better on the higher dose and strong types on the low dose. The first hypothesis was confirmed on a performance task but not on behavioral ratings. At the lower dose, augmenters improved most and reducers least on a 10-minute coding task presumed to require sustained attention. There was no support for the second hypothesis either in ratings or performance. The ERP augmentation measure was significantly related to teacher rated attentiveness; i.e., reducers and moderates were rated more adversely. The RT sensitivity measure tended to be related to achievement; i.e., strong types had lower reading and spelling scores. The ERP and RT sensitivity measures were not significantly correlated.
authors.affiliation: Arkansas Children's Hospital, Little Rock 72205.
authors.forename: P T
authors.initials: PT
authors.lastname: Ackerman
authors.forename: R A
authors.initials: RA
authors.lastname: Dykman
authors.forename: D M
authors.initials: DM
authors.lastname: Oglesby
mesh_terms: D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D004305:Dose-Response Relationship, Drug; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D008144:Loudness Perception / Q000187:drug effects*; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects*
chemical_list: D008774:Methylphenidate