[Hydrogen peroxide in the aqueous humor and cataract formation in human diabetes].
Hydrogen peroxide in the aqueous humor was measured in cataractous eyes from normal subjects and in cataractous eyes from diabetic subjects. The level of H2O2 in the aqueous humor was significantly higher in diabetes than in the idiopathic forms. It is likely that in the eye, impaired enzymic defenses lead to the accumulation of reactive species of O2, such as H2O2, which induces lipid peroxidation. This mechanism may be involved, as a direct consequence of retinal damage, in the pathogenesis of cataract in diabetes.
Simonelli
F
F
Clinica Oculistica della I Facoltà di Medicina e Chirurgia Università di Napoli.
Pensa
M
M
Teramo
P
P
Amicone
A
A
Russo
P
P
Perillo
F
F
Cotticelli
L
L
Rinaldi
E
E
D001082:Aqueous Humor / Q000737:chemistry*; D002386:Cataract / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D015227:Lipid Peroxidation; D010100:Oxygen / Q000378:metabolism
D005609:Free Radicals; D006861:Hydrogen Peroxide; D010100:Oxygen
Perossido di idrogeno nell'umore acqueo e catarattogenesi nel diabete umano.