Nuclear 3,5,3'-triiodothyronine receptors in skeletal muscle of normal and small-for-gestational age newborn piglets.
The number of nuclear T3 receptors in the longissimus dorsi muscle has been determined in normal and runt (intrauterine growth-retarded) newborn piglets. Values of maximal binding capacity (Bmax), as calculated by Scatchard analysis, were 48.2 +/- 4.3 and 39.7 +/- 4.7 mol X 10(-14).mg DNA-1 (mean values +/- SEM) for controls and runts respectively (p less than 0.01; n = 13 pairs of littermates). The lower Bmax in the runts may help to explain their reduced metabolic rate and lower respiratory enzyme activities in skeletal muscle, compared with controls of normal birth weight.
Dauncey
M J
MJ
Department of Cell Biology, AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
Geers
R
R
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D002467:Cell Nucleus / Q000378:metabolism*; D007700:Kinetics; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism*; D009929:Organ Size; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D012016:Reference Values; D013552:Swine
D011988:Receptors, Thyroid Hormone