[Correlation of the expression of A, B isoantigens with its precursor H antigen in transitional cell carcinoma and the clinical signification of the expression].
The expression of ABO (H) isoantigens in tumors from 96 patients with transitional cell carcinomas (TCC) and the precursor H antigen of A or B antigens were studied by using immunohistochemical technique (ABC method). In our series ABO(H)isoantigens were demonstrated in 57 of 96(59.4%), grade I 76.5%, II 69.4% and III 33.3% respectively. The deletion of ABO(H) isoantigens was related statistically with the histologic grade of TCC (P less than 0.01) and the recurrence of the tumors (P less than 0.05). The results showed that the expression of the precursor H substance was very well related with the expression of A or B isoantigen (r = 0.99, P less than 0.001). The deletion of precursor H substance could more reliably predict the clinical course of the subsequent recurrence and mortality in A, B or AB type blood patients with TCC than that of A or B isoantigen. Detecting H substance can substitute completely detecting A or B isoantigen in tumors of A, B or AB type blood patients, and has more practical value clinically.
Yang
S C
SC
Sichuan Provincial People's Hospital, Chengdu.
D000017:ABO Blood-Group System / Q000276:immunology*; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D007519:Isoantigens / Q000032:analysis*; D011379:Prognosis; D014571:Urologic Neoplasms / Q000276:immunology*
D000017:ABO Blood-Group System; D007519:Isoantigens