[Disorders of blood platelet homeostasis in patients with multiple myeloma before the treatment and during remission].
In 28 patients with plasmocytoma selected parameters of primary haemostasis were studied before treatment and 6-9 months later, in remission. We evaluated spontaneous aggregation, aggregation induced by ADP and adrenaline, platelet factor 3 availability and the realising platelet factor 4. Significant disturbances of primary haemostasis were particularly marked in patients with a high monoclonal protein concentration (greater than 3 g/dl). During remission an increase of platelet aggregation was noted. Its values, however, remained lower than in the control group.
Dmoszyńska-Giannopoulou
A
A
Kliniki Hematologii Katedry Chorób Wewnetrznych AM w Lublinie.
Kowalewski
J
J
Sokołowska
B
B
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D010976:Platelet Count / Q000187:drug effects; D012074:Remission Induction; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology*
Zaburzenia hemostazy płytkowej u chorych na szpiczaka plazmocytowego przed leczeniem i w okresie remisji choroby.