title: Studies on cardiotonic agents. IV. Synthesis of novel 1-(6,7-dimethoxy-4-quinazolinyl)piperidine derivatives carrying substituted hydantoin and 2-thiohydantoin rings.
abstract: A series of novel 1-(6,7-dimethoxy-4-quinazolinyl)piperidines carrying substituted hydantoin and 2-thiohydantoin rings was synthesized and examined for cardiotonic activity in anesthetized dogs. Introduction of isopropyl and sec-butyl group at the 5-position of the hydantoin and thiohydantoin rings led to potent inotropic activity. Effects of insertion of an alkyl chain between the piperidine and the hydantoin rings were also examined. The structural requirements necessary for optimal cardiotonic activity within the series were investigated.
authors.affiliation: Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Takai
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Teranishi
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004285:Dogs; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D006827:Hydantoins; D010880:Piperidines; D011799:Quinazolines; D013867:Thiohydantoins