[The interaction of neutrophilic granulocytes with Candida albicans fungi in the formation of mycotic foci under conditions of immunodepression].
In the electron-microscopic study of the interaction of neutrophil granulocytes with the fungal species C. albicans in the process of the formation of mycotic foci in mice under the conditions of cyclophosphamide-induced immunosuppression, mouse leukocytes have been found to retain their capacity for migration to the focus of inflammation and for the phagocytosis of fungal cells. At the same time the fungicidal activity of leukocytes is decreased, which is manifested by the prevalence of viable fungal cells with the partially digested cell wall in the cytoplasm of leukocytes.
Khokhlov
S E
SE
Pakhomova
E N
EN
Bykov
V L
VL
D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology; D005490:Focal Infection / Q000276:immunology* / Q000473:pathology; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology*; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*
D003520:Cyclophosphamide
Vzaimodeĭstvie neĭtrofil'nykh granulotsitov s gribami Candida albicans pri formirovanii mikoticheskikh ochagov v usloviiakh immunodepressii.