Hepatic vascular occlusion combined with adriamycin given by the hepatic artery in rats with adenocarcinoma in the liver.
Rats with an adenocarcinoma of the colon implanted into the liver were treated by a bolus injection of adriamycin by the hepatic artery. In addition, vascular occlusions were performed in the following three ways. 1. The hepatic artery was ligated (HAL) immediately after adriamycin injection. 2. The portal venous branch nourishing the tumor was ligated immediately after adriamycin injection. 3. The Pringle maneuvre (clamping of the hepatic artery, the portal vein and the common bile duct) was performed during 5 min before and 10 min after injection. Tumor size was measured at operation and 6 and 12 days later in the first experiment, 7 days later in the other two experiments. The combination of adriamycin and HAL retarded tumor growth at day 6 as compared to controls, adriamycin alone and HAL alone. The differences were not significant at day 12. The other vascular occlusions did not improve the antitumor effect of adriamycin.
Jakobsson
B
B
Department of Pathology, Lund University, Sweden.
el Hag
I A
IA
Roos
G
G
Stenram
U
U
D000230:Adenocarcinoma / Q000188:drug therapy / Q000628:therapy*; D000818:Animals; D001835:Body Weight; D003135:Common Bile Duct / Q000601:surgery*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D006499:Hepatic Artery / Q000601:surgery*; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains
D004317:Doxorubicin