title: [A case report of Creutzfeldt-Jakob disease associated with myocarditis].
abstract: We have encountered a case of Creutzfeldt-Jakob disease associated with myocarditis. A 77 year-old woman was admitted to a hospital with complaints of rapidly progressive visual disturbance, myoclonus and dementia. Electroencephalogram revealed a periodic synchronous discharge and Creutzfeldt-Jakob disease was suspected. Then she moved to our hospital, because acute myocarditis was combined with ST-T changes on electrocardiogram, and generalized hypokinetic motion of the left ventricle on echocardiogram. The abnormal findings in electrocardiography and echocardiography were transient. Blood levels of enzymes derived from the myocardium were slightly elevated. We could not find a distinct increase in the titer of neutralizing antibody to various viruses. In this case, the cause of myocarditis may have been associated with the infectious agent of Creutzfeldt-Jakob disease. This report might be the first one with a case of Creutzfeldt-Jakob disease complicated with myocarditis.
authors.affiliation: Department of Medicine, Wakayama Medical College.
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Ura
authors.forename: T
authors.initials: T
authors.lastname: Hano
authors.forename: I
authors.initials: I
authors.lastname: Nishio
authors.forename: Y
authors.initials: Y
authors.lastname: Masuyama
authors.forename: C
authors.initials: C
authors.lastname: Fujikawa
authors.forename: M
authors.initials: M
authors.lastname: Siba
authors.forename: Y
authors.initials: Y
authors.lastname: Azuma
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications*; D004452:Echocardiography; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed