[The inefficacy of zidovudine (AZT) in progressive multifocal leukoencephalopathy (PML) associated with the acquired immunodeficiency syndrome (AIDS)].
The clinical case of a patient suffering AIDS who presented a progressive multifocal leukoencephalopathy (PML), diagnosed by CT scan, magnetic resonance imaging (MRI) and cerebral biopsy, is here described. A therapeutic trial was carried out with zidovudine (200 mg/4 hours p.o.) during 75 days. Although this treatment diminished the number of infections, a progression of PML was clinically observed, as well as the appearance of new lesions in the cerebral white matter in the MRI. The inefficacy of zidovudine in PML associated to AIDS is discussed.
Garrote
F J
FJ
Servico de Medicina Interna, Hospital Severo Ochoa, Leganés, Mádrid.
Molina
J A
JA
Lacambra
C
C
Mollejo
M
M
Madero
S
S
del Ser
T
T
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D001706:Biopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004341:Drug Evaluation; D015497:HIV-1; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D015215:Zidovudine / Q000627:therapeutic use*
D015215:Zidovudine
Ineficacia de la zidovudina (AZT) en la leucoencefalopatía multifocal progresiva (LMP) asociada al síndrome de inmunodeficiencia adquirida (SIDA).