Clinical, blood gas, and lactate changes in the course of the treatment of peripheral vascular disease with a hemodialysate.
In a double-blind comparison with placebo, treatment with a hemodialysate (Solcoseryl) in severe peripheral vascular disease (PVD) resulted in a distinct improvement in symptomatology and clinically observed pathology. Initially depressed ApO2 was normalized with a corresponding increase in AO2 saturation, an increase in A-V pO2 difference, and reduction of elevated blood lactate levels. Correction of disturbed O2 diffusion is postulated to explain these observations. The mechanism proposed may be operative in lung-to-blood, blood-to-tissue, within-tissue and within-cell aspects of oxygen transport under pathologic conditions.
Rossano
C
C
Department of Analgesia, Regional General Hospital, Ancona, Italy.
Weiner
M
M
Haigis
E
E
D000183:Actihaemyl / Q000627:therapeutic use*; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications; D001784:Blood Gas Analysis; D004311:Double-Blind Method; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D059408:Pain Management; D014652:Vascular Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
D007773:Lactates; D000183:Actihaemyl