Effect of exercise on propranolol pharmacokinetics.
The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable. This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.
Frank
S
S
Department of Medicine, Southern Illinois University School of Medicine, Springfield.
Somani
S M
SM
Kohnle
M
M
D000328:Adult; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D005082:Physical Exertion; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D011433:Propranolol