title: Transitional cell carcinoma of the urinary bladder with osteoclast-type giant cells: a report of two cases and review of the literature.
abstract: We report two transitional cell carcinomas of the urinary bladder containing numerous osteoclast-type giant cells that stained for vimentin and acid phosphatase (with and without tartrate) and were negative for cytokeratin and lysozyme. One tumour, in a 65-year-old man, was composed of papillary transitional cell carcinoma, invasive poorly differentiated carcinoma with a prominent spindle cell component and numerous osteoclast-type giant cells; repeat curettage 2 months later showed no residual tumour. The second tumour occurred in a 75-year-old woman who underwent a radical cystectomy for a deeply invasive transitional cell carcinoma with a spindle and anaplastic giant cell component and areas containing numerous osteoclast-type giant cells. Osteoclast-type giant cells, which appear to be reactive, should be distinguished from the neoplastic giant cells of giant cell carcinoma.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Boston 02114.
authors.forename: L R
authors.initials: LR
authors.lastname: Zukerberg
authors.forename: A R
authors.initials: AR
authors.lastname: Armin
authors.forename: L
authors.initials: L
authors.lastname: Pisharodi
authors.forename: R H
authors.initials: RH
authors.lastname: Young
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin; D000135:Acid Phosphatase