title: [The effect of tissue preparations on the development of anaphylaxis].
abstract: The paper analyses results of experimental studies conducted in 60 guinea pigs with the purpose to determine the influence of preparations of a group of distillate (torfot, FiBS) and protein preparations of vegetable (aloe extract) and animal (extract of placenta) origin on the development of a reaction of hypersensitivity of a delayed type. It was found that tissue preparations both in doses adequate to those used in clinic (0.03 ml) and in doses biologically active in pharmacologic tests (0.3 ml) don't stimulate the development of anaphylactic shock and the usage of FiBS leads to a remarkable reduction of its manifestations in experimental animals. The results obtained speak about the difference between immunomodulating influence of the preparation of a group of distillates and protein preparations on the development of anaphylaxis and allow to show, for the first time, a desensitizing action of a bioregulator of medicinal peloids (FiBS).
authors.forename: T V
authors.initials: TV
authors.lastname: Degtiarenko
mesh_terms: D000485:Allergens / Q000008:administration & dosage; D000707:Anaphylaxis / Q000209:etiology / Q000628:therapy*; D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000628:therapy; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000628:therapy; D014020:Tissue Extracts / Q000276:immunology / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D000485:Allergens; D014020:Tissue Extracts
vernacular_title: Vliianie tkanevykh preparatov na razvitie anafilaksii.