Mathematical modelling of metabolic pathways affected by an enzyme deficiency.
The regulation of metabolic pathways of the red cell affected by an enzyme deficiency is studied on the basis of comprehensive mathematical models. The main steps of such a theoretical approach are outlined considering individual alterations in the kinetic properties of two regulatory enzymes: pyruvate kinase and glucose-6-phosphate dehydrogenase. It is demonstrated that mathematical modelling helps to relate the observed changes of cellular quantities as shortened life-span, or as resistance against oxidative stress to alterations in the metabolic regulation.
Holzhütter
H G
HG
Institut für Biochemie, Bereich Medizin (Charité), Humboldt Universität Berlin.
Schuster
R
R
Buckwitz
D
D
Jacobasch
G
G
D000818:Animals; D003198:Computer Simulation; D004912:Erythrocytes / Q000201:enzymology*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011770:Pyruvate Kinase / Q000172:deficiency*
D011770:Pyruvate Kinase