title: Gender, age and circadian blood pressure variation of apparently healthy rural vs metropolitan Japanese.
abstract: Interim chronobiologic cardiovascular reference data have been described; 353 clinically healthy Japanese subjects were monitored every 15 min for 24h on 2 occasions. Special attention was paid to the difference between metropolitan and rural areas. Not only the MESORs of SBP and DBP, but also the circadian amplitudes, were higher in the Tokyo than in a rural area (Komaki, Aichi Prefecture). Age-related alterations in the circadian profile of cardiovascular variables were noted for women but not for men. The average MESOR remained similar for SBP in men, whereas in women the average MESOR increased with advancing age in both urban and rural areas. The average circadian amplitude of SBP also increased with age in women, but not in men. No significant deviations of acrophase with age were found for SBP and DBP in men, whereas in rural women the acrophase tended to occur earlier with increasing age.
authors.affiliation: Department of Medicine, Tokyo Women's Medical College, Daini Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: M
authors.initials: M
authors.lastname: Shinoda
authors.forename: K
authors.initials: K
authors.lastname: Uezono
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012737:Sex Factors; D014505:Urban Population