Preventive effect of angiotensin I on weight reduction in the adrenal glands of DOCA/salt hypertensive rats.
We examined the effect of angiotensin I (AI), without the effect of angiotensin II (AII) converted from AI, on the weight of the adrenal glands, adrenal corticosterone (B) and adrenal aldosterone under conditions where the renin-angiotensin system was suppressed, since a reduction in the size of the adrenal glands is often observed in DOCA/salt hypertensive rats. Sixty male Wistar rats fed on a 1% NaCl solution were divided into 6 groups as follows: a) Salt group: received sesame oil and vehicle, b) Salt + C group: received sesame oil and MK422 (0.14 mg/day), an angiotensin converting enzyme inhibitor (CEI), c) DOCA group: received DOCA (30 mg/week) and vehicle, d) DOCA + A group: received DOCA and AI (0.5 mg/kg/day), e) DOCA + A + C group: received DOCA and AI with MK422, and f) DOCA + C group: received DOCA and MK422. After 4 weeks, the rats were sacrificed to sample their blood and remove their adrenal glands. There was no significant difference in adrenal B among the groups apart from the DOCA + C group. Adrenal aldosterone was lower in the groups of DOCA/salt hypertensive rats than in the Salt group and Salt + C group. Furthermore, the DOCA + A + C group and DOCA + C group had lower adrenal aldosterone levels than the DOCA group and DOCA + A group.(ABSTRACT TRUNCATED AT 250 WORDS)
Watanabe
M
M
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Honda
M
M
Soma
M
M
Minato
M
M
Fukuda
N
N
Watanabe
Y
Y
Izumi
Y
Y
Hatano
M
M
D000311:Adrenal Glands / Q000473:pathology*; D000450:Aldosterone / Q000378:metabolism; D000803:Angiotensin I / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000378:metabolism; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012965:Sodium Chloride
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D000450:Aldosterone; D000803:Angiotensin I; D012083:Renin; D003345:Corticosterone