title: Long-term depressor effects of catecholamine neuronal grafts in the third ventricle of the brain in normotensive rats.
abstract: Neuronal tissue containing A-6 group noradrenalin (NA) neurons of the locus ceruleus, or A-10 group dopamine (DA) neurons of the substantia nigra, was grafted into the third ventricle at the level of the preoptic-anterior hypothalamic region, in normotensive male rats. A significant and long-lasting depressor effect was shown in rats with either graft. In rats with an NA neuron-rich graft, plasma concentrations of arginine-vasopressin (AVP), plasma renin activity (PRA), and corticosterone (CS) decreased significantly, whereas in rats with a DA neuron-rich graft, AVP and PRA concentrations also decreased significantly but CS showed no significant change. Neither NA nor adrenalin in plasma changed significantly in rats with either graft.
authors.affiliation: Department of Physiology II, Yokohama City University School of Medicine, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hashimoto
authors.forename: F
authors.initials: F
authors.lastname: Kimura
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000502:physiology*; D006339:Heart Rate; D007032:Hypothalamus, Anterior; D008125:Locus Coeruleus / Q000166:cytology / Q000637:transplantation*; D008297:Male; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D013378:Substantia Nigra / Q000166:cytology / Q000637:transplantation*
chemical_list: D001127:Arginine Vasopressin; D012083:Renin; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine