title: Acetylation phenotypes and bladder cancer.
abstract: The human population consists of slow and fast acetylators. To test the hypothesis that slow acetylators are predisposed to bladder cancer caused by exposure to aromatic amines, we performed a retrospective study, phenotyping cancer patients. Bladder cancer patients were divided, based on interview data, into two groups: those with and without occupational exposure to aromatic amines. The nonexposed group had a distribution of slow acetylators (60.5%) similar to that in the general Polish population. (A group of controls was 45.4% slow acetylators.) The exposed group was predominantly slow acetylators (87.6%). A prospective study in a currently healthy occupationally exposed cohort has been initiated to investigate possible change in acetylator phenotype with disease or therapy onset. Cohort members have been typed for acetylator status; a tumor marker (to identify bladder cancer at a preclinical stage) and acetylator status will be measured periodically.
authors.affiliation: Department of Laboratory Diagnostics, Nofer's Institute of Occupational Medicine, Lodz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Hanke
authors.forename: B
authors.initials: B
authors.lastname: Krajewska
mesh_terms: D000107:Acetylation; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics*; D010641:Phenotype; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000235:genetics*