A new dual-label technique for platelet survival studies with the use of 111indium and 114mindium tropolonate.
A dual-label technique to study the survival of two different populations of platelets within one individual was developed using 111indium and 114mindium. The validity of the technique was demonstrated in seven individuals with an expected equal survival time of two platelet populations and in two persons with an expected difference in platelet survival time. Since the energy spectra of the two indium isotopes are very close, a well-type germanium semiconductor detector was applied. By adaptation of the counting time the effective dose equivalent of the dual-label procedure could be restricted to 1.6 mSv. The dual-label technique provides an instrument for studying the survival of two different populations of platelets simultaneously within one individual.
de Vries
R A
RA
Eemland Hospital, Department of Internal Medicine and Clinical Chemistry, Amersfoort, The Netherlands.
de Bruin
M
M
Oldenburg
S J
SJ
Zwiers
A
A
Marx
J J
JJ
Poortman
J
J
Hart
H C
HC
van de Wiel
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000000981:diagnostic imaging* / Q000502:physiology; D002470:Cell Survival; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010979:Platelet Function Tests / Q000379:methods; D011877:Radionuclide Imaging; D014334:Tropolone / Q000031:analogs & derivatives
D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C043895:indium tris(tropolonate); D014334:Tropolone