Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis.
The purpose of this study was to identify mediators of brain oedema formation in experimental pneumococcal meningitis. In a rat model of pneumococcal meningitis brain water content was significantly elevated 6 hours post infection (79.69% +/- 0.24 compared to 78.94% +/- 0.16 in the control group, mean +/- SEM, p less than 0.05). Brain oedema formation was completely blocked by superoxide dismutase (132,000 U/kg i.v. per 6 hours: n = 6), pretreatment with dexamethasone (3 mg/kg i.p., n = 3), or administration of dexamethasone at two hours after pneumococcal injection (n = 5). Pretreatment with indomethacin (10 mg/kg i.v., n = 5) attenuated the brain oedema formation. These findings suggest that oxygen derived free radicals act as mediators of brain oedema formation during the early phase of experimental bacterial meningitis. Cyclooxygenase metabolites may provide one possible source for the generation of oxygen derived free radicals in bacterial meningitis.
Pfister
H W
HW
Department of Neurology, University of Munich, Federal Republic of Germany.
Koedel
U
U
Dirnagl
U
U
Haberl
R L
RL
Feiden
W
W
Einhäupl
K M
KM
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000517:prevention & control*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D008586:Meningitis, Pneumococcal / Q000150:complications* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013997:Time Factors
D003907:Dexamethasone; D013482:Superoxide Dismutase