[Effect of buprenorphine on external pancreatic secretion in rats].
2-deoxyglucose stimulates pancreatic secretion through a mainly vagal neural pathway. Buprenorphine antagonized this stimulation in a dose-related fashion between 0.017 and 0.45 mg/kg. i.v. The effect of buprenorphine was suppressed by naloxone, but not by alpha and beta-adrenoceptor blocking agents. The effect of methadone was similar, at doses about ten times larger.
Nagain
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INSERM U 239, Faculté de Médecine Xavier Bichat, Paris.
Chariot
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Roze
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Vaille
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D000818:Animals; D002047:Buprenorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D008297:Male; D008691:Methadone / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009270:Naloxone; D002047:Buprenorphine; D003847:Deoxyglucose; D008691:Methadone
Action de la buprénorphine sur la sécrétion pancréatique externe chez le rat.