Constituents of a fern, Davallia mariesii Moore. I. Isolation and structures of davallialactone and a new flavanone glucuronide.
A new gamma-lactone derivative named davallialactone (4) and the 7-O-beta-D-glucuronide of (+/-)-eriodictyol (5a) have been isolated from Davallia mariessi Moore along with caffeic acid (1), 4-beta-D-glucopyranosylcaffeic acid (2) and 4-O-beta-D-glucopyranosyl-p-coumaric acid (3). The structures of the new compounds were determined by chemical and spectroscopic methods including two-dimensional nuclear magnetic resonance (2D NMR) techniques, especially 1H-detected heteronuclear multiple-bond multiple-quantum coherence and long-range C-H J-resolved 2D NMR techniques.
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Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Tezuka
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Kikuchi
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Nakano
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Tamaoki
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Park
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011905:Genes, ras; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors
D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; D005419:Flavonoids; D005965:Glucuronates; D007783:Lactones; C068766:davallialactone; C068767:eriodictyol 7-glucuronide; D011493:Protein Kinase C