Carbapenem and penem antibiotics. V. Synthesis and antibacterial activity of 2-functionalized-methyl 1-methylcarbapenems related to asparenomycins.
The synthesis of 1 alpha- and/or 1 beta-methylcarbapenems, 2-unsubstituted and 2-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl derivatives having a 1-(hydroxy)methylethylidene or cyclic carbonate side chain at the C-6 position, is described. The in vitro antibacterial activities of these compounds and their corresponding 1-unsubstituted carbapenems are compared.
Imuta
M
M
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Uyeo
S
S
Yoshida
T
T
D013845:Thienamycins / Q000138:chemical synthesis* / Q000494:pharmacology
D013845:Thienamycins; C031989:asparenomycin