title: [The use of influenza vaccines and remantadine for protection against influenza in industrial enterprises].
abstract: The effectiveness of inactivated and live influenza vaccines and remantidin was studied in persons with different annual morbidity rate in influenza and acute respiratory diseases (ARD). After three and more years of immunization with the inactivated vaccine the number of seroconversions to viruses A (H1N1) and A (H3N2) in vaccinees decreased, respectively, from 75.0 to 26.0% and from 79.3 to 38.8%, and after an interval of two years or the alternation of inactivated and live vaccines the number of seroconversions increased to 57.9-64.0%. The significant decrease of morbidity rate in influenza and ARD were observed only in persons, having had frequent ARD in their medical history and immunized with live and inactivated vaccines simultaneously or separately with the alternation of these vaccines every year (the effectiveness index being equal to 1.7-1.8). At the period of epidemic the controlled administration of remantadin to persons with contraindications to immunization ensured the decrease of morbidity rate in influenza 1.5-1.8 times; in vaccinees, highly susceptible to ARD, the administration of remantadin decreased morbidity rate 2.3 times.
authors.forename: I A
authors.initials: IA
authors.lastname: Mal'chikov
authors.forename: A V
authors.initials: AV
authors.lastname: Slobodeniuk
mesh_terms: D000075202:Contraindications; D004341:Drug Evaluation; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D009784:Occupational Diseases / Q000276:immunology / Q000517:prevention & control*; D012299:Rimantadine / Q000627:therapeutic use*; D012621:Seasons; D012800:Siberia / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D012299:Rimantadine
vernacular_title: Primenenie grippoznykh vaktsin i remantadina dlia zashchity ot grippa na promyshlennykh predpriiatiiakh.