[The effects of vitamin D2 on the lipid profile and on the platelet and cardiovascular activities in castrated or testosterone-treated male rats].
The changes in serum and hepatic lipid fractions (LT, Col, TG, beta-LP), aggregability indices (IAg), platelet adhesiveness (IA), atherogenicity (Ia) and microscopic aspect of aorta and myocardium in three groups of animals injected with vitamin D2: normal, orchiectomized and treated with testosterone, were followed up. In the normal animals the injection of vitamin D2 induced the increase of all lipid fractions, of IA, IAg, Ia and histologically microcalcifications at the coronaries level were present; in the orchiectomized animals the biochemical changes were less marked and histologically thickenings of aortic and coronary endothelium with areas of intestinal sclerosis in the myocardium were found. In the animals with hyperandrogenism, the administration of vitamin D2 induced the decrease of TG and increase of IAg and IA; histologically, aspects similar to those noticed after the administration of testosterone alone were present. It is concluded that hypervitaminosis D induces a marked increase of serum lipid fractions in the normal animals, while the histological examination revealed more marked changes in conditions of sexual function cessation.
Dinu
M
M
Disciplinele de fiziopatologie şi histologie, Institutul de Medicină şi Farmacie Iaşi.
Sneer
A
A
Colev
V
V
Bădescu
M
M
Dughir
E
E
Dobrescu
G
G
Stanciu
J
J
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D004872:Ergocalciferols / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009919:Orchiectomy; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D004872:Ergocalciferols; D008055:Lipids; D013739:Testosterone
Efectele vitaminei D2 asupra profilului lipidic, activităţii plachetare şi cardiovasculare la şobolani masculi castraţi sau trataţi testosteron.