Inhibition of human gastric acid secretion by peptide YY and secretin.
In 6 healthy volunteers we investigated the effect of secretin and peptide YY (PYY) on gastric acid secretion stimulated by pentagastrin (100 ng/kg/h). Secretin (0.05 CU/kg/h) and PYY (10.0 pmol/kg/h) were given intravenously either alone or in combination. Given alone secretin and PYY inhibited gastric acid output by 25 and 21%, respectively. The combined infusion of secretin and PYY inhibited acid output by 38% indicating an additive effect. The infusion of one hormone did not influence release of the other. It is suggested that the interaction of PYY and secretin on pentagastrin-stimulated gastric acid secretion in normal man is of the additive type.
Olsen
O
O
Department of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.
Christiansen
J
J
D000328:Adult; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D019894:Peptide YY; D010455:Peptides / Q000502:physiology*; D012633:Secretin / Q000502:physiology*
D005768:Gastrointestinal Hormones; D010455:Peptides; D019894:Peptide YY; D012633:Secretin; D010418:Pentagastrin