Infantile fibrosarcoma--a misnomer?
Two cases of congenital or infantile fibrosarcoma are described that were incompletely excised at the time of primary excision and have not recurred or metastasized after 3 years. The tumors were composed of densely cellular spindle cells with a high mitotic index. Immunohistochemical stains were positive for vimentin but negative for desmin and S-100. The tumor cells were grown in vitro, and a karyotype was obtained. Both tumors had normal diploid modal karyotypes. In addition, fragments of the primary tumor from both cases were injected subcutaneously into nude mice; neither tumor could be heterotransplanted. The clinical course and biologic features of these two tumors suggest that congenital or infantile sarcoma does not have the properties of a malignant neoplasm, and thus the designation of these tumors as a sarcoma may be a misnomer.
Wilson
M B
MB
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Stanley
W
W
Sens
D
D
Garvin
A J
AJ
D000818:Animals; D003582:Cytogenetics; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D009626:Terminology as Topic; D014183:Transplantation, Heterologous