[A morphological evaluation of the tissue status of the oral mucosa after anesthesia applied with dicaine and pyromecaine solutions].
Effects of aqueous dicaine and pyromecaine solutions on mucosal tissue structures were studied in 40 syrian hamsters. The results evidence that when dicaine, an ether anesthetic, is applied, injuries prevail over reactive phenomena: a manifest cytotoxic effect of the drug can be seen at all phases of the follow-up, this effect being observed both in the mucosal epithelium and in the deeper layers of the mucosa. An amide anesthetic, pyromecaine, is not characterized by a cytotoxic action on mucosal epithelium cells, though in later periods of the experiment it also may induce side effects presenting as an acute inflammatory reaction developing in the subepithelial [correction of polyepithelial] connective tissue stroma and muscular layer.
Panikarovskiĭ
V V
VV
Grigor'ian
A S
AS
Polevaia
N P
NP
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D006224:Cricetinae; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D011759:Pyrrolidines / Q000633:toxicity*; D012996:Solutions; D013748:Tetracaine / Q000633:toxicity*; D013997:Time Factors
D000779:Anesthetics, Local; D011759:Pyrrolidines; D012996:Solutions; D013748:Tetracaine; C000661:bumecain
Morfologicheskaia otsenka sostoianiia tkaneĭ slizistoĭ obolochki rta posle applikatsionnoĭ anestezii rastvorami dikaina i piromekaina.