title: Circadian variations of total renin, active renin, plasma renin activity and plasma aldosterone in clinically healthy young subjects.
abstract: The direct assay of total renin (TRC) and active renin concentration (ARC) is a reality due to the availability of monoclonal antibodies against human renin. Because of this, a study has been performed in order to assess the circadian rhythmicity of TRC and ARC. The study was extended to plasma renin activity (PRA) and plasma aldosterone concentration (PAC) for a more complete assessment of the renin-angiotensin-aldosterone system (RAAS). Twelve clinically healthy subjects (6 males and 6 females, age from 20 to 25 years) volunteered for this study. Time-qualified data series were analysed by means of chronobiological procedures in order to validate the circadian rhythm and to correlate the sinusoidal profiles. The circadian rhythm was validated at a high significance for TRC, ARC, PRA and at a borderline significance for PAC. The periodic oscillations were significantly correlated, demonstrating that TRC, ARC, PRA and PAC cycles oscillate in synchronism during the 24-hour span.
authors.affiliation: Institute of Health Science, Kyushu University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: K
authors.initials: K
authors.lastname: Uezono
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Nishiura
authors.forename: K
authors.initials: K
authors.lastname: Shinkawa
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D000450:Aldosterone; D012083:Renin