title: Fosfomycin trometamol (Monuril) versus norfloxacin in single dose for adult female uncomplicated UTIs. Multicenter randomized, double-blind study.
abstract: The efficacy, tolerability and side effects of a 'single-dose' therapy for acute female lower UTIs in general practice with fosfomycin trometamol (3 g) or norfloxacin (800 mg) were compared in a randomized double-blind study. 89 patients were included in the trial; however, 36 (40.4%) did not present significant bacteriuria and were assessed mainly for tolerability. Of the 53, 28 patients in the fosfomycin trometamol group and 25 patients in the norfloxacin group, 21 (75%) had no bacteriuria at immediate follow-up after treatment with fosfomycin trometamol and 20 (84%) with norfloxacin. The tolerability of both drugs in single dose was absolute.
authors.affiliation: Department of Surgery/Surgical Nephrology, University of Bari, Italy.
authors.forename: F P
authors.initials: FP
authors.lastname: Selvaggi
authors.forename: P
authors.initials: P
authors.lastname: Ditonno
authors.forename: A
authors.initials: A
authors.lastname: Traficante
authors.forename: M
authors.initials: M
authors.lastname: Battaglia
authors.forename: V
authors.initials: V
authors.lastname: Di Lorenzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001437:Bacteriuria / Q000188:drug therapy*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D005578:Fosfomycin; D009643:Norfloxacin