Plasma renin activity, angiotensin II, prostacyclin and thromboxane A2 concentrations in 139 preeclamptic patients.
Plasma renin activity, plasma concentrations of angiotensin II (AngII), stable metabolites (6-keto-prostaglandin F1 alpha: 6-keto-PGF1 alpha) of prostacyclin (PGI2) and a metabolite (thromboxane B2: TXB2) of thromboxane A2 (TXA2) were measured with radioimmunoassay(RIA) in 107 normal pregnancy (control) and 139 preeclamptic patients in 28-41 gestational weeks. PRA and 6-keto-PGF1 alpha were significantly higher and AngII was slightly higher in preeclampsia than in control, and TXB2 was significantly lower in preeclampsia in control. The ratio of 6-keto-PGF1 alpha/TXB2 was significantly lower in preeclampsia than in control. These data suggest that the changes in the renin-angiotensin system may not be primary alterations in preeclampsia. It can be speculated that in preeclampsia the changes in absolute concentrations of 6-keto-PGF1 alpha and TXB2 are less important than the decrease in the ratio of the 6-keto-PGF1 alpha/TXB2.
Furuhashi
N
N
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Tsujiei
M
M
Kimura
H
H
Yajima
A
A
Kimura
C
C
Ide
Y
Y
D000328:Adult; D000804:Angiotensin II / Q000097:blood / Q000502:physiology*; D011464:Epoprostenol / Q000097:blood / Q000502:physiology*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011863:Radioimmunoassay; D012044:Regression Analysis; D012083:Renin / Q000097:blood / Q000502:physiology*; D013928:Thromboxane A2 / Q000097:blood / Q000502:physiology*
D000804:Angiotensin II; D013928:Thromboxane A2; D011464:Epoprostenol; D012083:Renin