Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica.
The known bruceanic acid A [1] and its methyl ester 2, as well as the new bruceanic acids B [3], C [4], and D [5], have been isolated from Brucea antidysenterica. The structures of 1-5 were elucidated by spectral data. Compound 1 demonstrated cytotoxicity against KB and TE671 tumor cells. Compound 5 was cytotoxic against P-388 lymphocytic leukemia cells.
Toyota
T
T
Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Fukamiya
N
N
Okano
M
M
Tagahara
K
K
Chang
J J
JJ
Lee
K H
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D036702:Quassins; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004952:Esters; D036702:Quassins; C068524:bruceanic acid C; C068525:bruceanic acid D; C068523:bruceanic acid B; C068522:bruceanic acid A; C068526:bruceanic acid A methyl ester; D005900:Glaucarubin