[Granulocytic "deactivation" in cold urticaria].
Recent advance about pathogenesis of Idiopathic acquired Cold-induced Urticaria underline the role of Neutrophils that, drawn by a specific mast-cell factor (HMW-NCF) might characterise precise stages of disease and presumably specific histologic "subset". This factor together with the chemotactic factor for eosinophils (ECF) can determine the so called neutrophils' "deactivation". In this study we have valued the role of neutrophils in six patients with idiopathic cold-induced urticaria and in a group of control including both patients with other forms of urticaria and healthy controls. The results of our research show the absence of alterations either in cellular neutrophilic chemotaxis or the serum one. Furthermore we have been able to determine that this "deactivation" is specific for idiopathic cold-induced urticaria and that it does not happen in the other forms of physical or non urticaria.
Del Sere
F
F
Clinica Dermosifilopatica I, Università degli Studi di Firenze.
Gerini
G
G
Velluzzi
M
M
Petrini
N
N
Fabbri
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte; D002648:Child; D003080:Cold Temperature / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology
La "deattivazione" granulocitaria nell'orticaria da freddo.