Some problems in the structural elucidation of fungal metabolites.
In the structural elucidation of natural products, problems may arise owing to extensive signal overlap and line broadening in the NMR spectra as well as unexpected chemical reactions. This is illustrated in the analysis of some novel compounds isolated from fruit bodies of toadstools and slime moulds, including infractopicrin, lascivol, retipolide A, arcyroxepin A and rubroflavin. In some cases, the problems could be solved by spectroscopic techniques such as two-dimensional INADEQUATE experiments, nuclear Overhauser enhancement measurements or X-ray structural analysis; in other cases, chemical transformations were necessary to resolve the structure.
Steglich
W
W
Institut für Organische Chemie und Biochemie, Universität Bonn, Federal Republic of Germany.
Steffan
B
B
Eizenhöfer
T
T
Fugmann
B
B
Herrmann
R
R
Klamann
J D
JD
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D005658:Fungi / Q000032:analysis*; D005971:Glutamates / Q000737:chemistry / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification; D012664:Semicarbazones / Q000737:chemistry / Q000302:isolation & purification; D013440:Sulfides / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005971:Glutamates; D007211:Indoles; D010647:Phenyl Ethers; D010860:Pigments, Biological; D012664:Semicarbazones; D013440:Sulfides; D014315:Triterpenes; C068341:lascivol; C068344:rubroflavin; C068342:retipolide A; C068340:crystallopicrin; C068343:arcyroxepin A