Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine.
Pain was induced in 19 healthy individuals by double-blind injections into the temporal muscle of 0.2 ml of physiological saline with or without active substances added. 5-Hydroxytryptamine (2 nmol) caused pain similar to saline, bradykinin (2 nmol) only insignificantly more pain (0.05 less than p less than 0.1), while a mixture of the two substances in half dosage (1 nmol + 1 nmol) caused pain significantly above saline (p less than 0.01). Variations in the response to saline did not permit a conclusion to be made on the question of induced tenderness. However, the mixture of the two substances appeared to lower the pressure-pain threshold as measured by a pressure algometer (p less than 0.05).
Jensen
K
K
Department of Neurology, Gentofte Hospital, University of Copenhagen, Denmark.
Tuxen
C
C
Pedersen-Bjergaard
U
U
Jansen
I
I
Edvinsson
L
L
Olesen
J
J
D000328:Adult; D001920:Bradykinin / Q000633:toxicity*; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000139:chemically induced / Q000503:physiopathology*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010147:Pain Measurement / Q000379:methods; D011312:Pressure; D011897:Random Allocation; D012701:Serotonin / Q000633:toxicity*; D013703:Temporal Muscle / Q000187:drug effects*
D012701:Serotonin; D001920:Bradykinin