[Influence of bacterial combinations on the post-antibiotic effect].
A study of the post-antibiotic effect (PAE) and letality curves of different concentrations of clavulanic acid, amoxycillin, amoxycillin + clavulanic acid, netilmycin and ofloxacin on mixed cultures of S. aureus and E. coli. The post-antibiotic effect was measured after one hour of exposure of bacteria to antimicrobial and the elimination of the latter by the dilution method. Amoxycillin did not induce PAE on the association. PAE only appeared at high concentrations on S. aureus when evaluated alone. Clavulanic acid induced a greater PAE than amoxycillin. The association clavulanic acid + amoxycillin was synergistic and induced a greater PAE than its components. Netilmycin and ofloxacin were the drugs that induced the greatest PAE on the bacterial association and on its strains independently evaluated.
Mínguez
F
F
Departamento de Microbiologiía, Facultad de Medicina, Universidad Complutense, Madrid.
Aparicio
P
P
Lurueña
S
S
Cabronero
M J
MJ
Prieto
J
J
D000658:Amoxicillin / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D009428:Netilmicin; D000658:Amoxicillin; D015242:Ofloxacin
Influencia de las asociaciones bacterianas sobre el efecto postantibiótico.