Synthesis of a new class of 1,4-dihydropyridines having a hydroxamic ester group in position 3 with a potential calcium antagonistic activity.
The synthesis of new 1,4-dihydropyridines having a hydroxamic acid or hydroxamic ester group in position 3 is described. Pharmacological evaluation included calcium antagonistic activity in the guinea pig Taenia coli test and acute toxicity. The compounds had not a calcium antagonistic activity, if compared with other well known DHP utilized as standard, so the pharmacological tests were not furtherly studied.
Inglesi
M
M
Department of Chemistry, Pierrel S.P.A., Milano, Italy.
Nicola
M
M
Magnetti
S
S
D000818:Animals; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D008055:Lipids