title: Transcobalamins in the etiology of neural tube defects.
abstract: In a sample of 79 pregnant women at risk offspring with neural tube defects (NTDs) and 158 controls, significantly increased median values were found for apo-transcobalamins I and II in amniotic fluid in the group at risk, thus confirming previous results. The findings may reflect a genetic disposition to NTDs associated with altered levels of apo-transcobalamins, and research on the etiology and mechanisms of NTDs should focus on these proteins.
authors.affiliation: Department of Epidemiology, National Institute of Public Health, Oslo, Norway.
authors.forename: P
authors.initials: P
authors.lastname: Magnus
authors.forename: E M
authors.initials: EM
authors.lastname: Magnus
authors.forename: K
authors.initials: K
authors.lastname: Berg
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000175:diagnosis / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D014155:Transcobalamins / Q000032:analysis / Q000235:genetics*
chemical_list: D014155:Transcobalamins