[Perfusion hyperthermia of the liver in swine--presentation of procedure for precise control of extreme hyperthermia].
Porcine liver was perfused by heated blood for 45 min. Vascular isolation was not needed as blood was collected from the aorta, heated and infused in the portal vein by a roller pump. Blood temperature was 43 degrees C, 43.2 degrees C, 43.6 degrees C and 44 degrees C. During perfusion, the liver was thermally insulated by a double layer polyethylene sheet. One pig died during perfusion because of a cardiac arrest, another pig after perfusion of 44 degrees C because of an acute liver failure. Serological examinations after perfusion showed a transient increase of liver enzymes. Morphological changes were obvious but seemed to be reversible. These examinations proved that by this method porcine liver can be heated precisely and homogeneously at temperatures required for extreme hyperthermia.
Zoedler
T
T
Chirurgische Klinik A, Universität Düsseldorf.
Braasch
D
D
Becker
H
H
Ebener
C
C
Röher
H D
HD
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D013552:Swine; D013556:Swine, Miniature; D014022:Tissue Survival / Q000502:physiology
Perfusionshyperthermie der Leber bei Schweinen--Darstellung eines Verfahrens zur präzisen Steuerung der extremen Hyperthermie.