title: EEG development in early treated PKU patients from birth to 6 years of age.
abstract: In 126 early treated PKU patients (type I and type II) a close EEG follow up was performed from birth up to 6 years of age. A total of 1465 EEGs were performed before and after onset of dietary treatment and on 11 more subsequent occasions. The composition of the background activity was normal up to 6 years when only a small number of the children (19) showed no dominant alpha activity. The frequency of epileptiform activity of generalised as well as focal type was low in the first 2 years of life, but afterwards slightly enhanced in comparison to normal control groups. Other findings like generalised theta paroxysms or focal slow waves were rarely observed. Under a standardised protein load at 6 months (52 patients) and at 5 years of age (42 patients) a moderate generalised slowing of the background activity but no other abnormalities were noted.
authors.affiliation: Ruprecht-Karls Universität Heidelberg, Kinderklinik, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Pietz
authors.forename: A
authors.initials: A
authors.lastname: Lütcke
authors.forename: D
authors.initials: D
authors.lastname: Sontheimer
authors.forename: C
authors.initials: C
authors.lastname: Benninger
authors.forename: B
authors.initials: B
authors.lastname: Pietz
authors.forename: U
authors.initials: U
authors.lastname: Batzler
authors.forename: A
authors.initials: A
authors.lastname: Heusser
mesh_terms: D000375:Aging / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy / Q000503:physiopathology*
chemical_list: D010649:Phenylalanine