title: Antigen processing and presentation in vivo: the microenvironment as a crucial factor.
abstract: Antigen processing and presentation in vitro is an increasingly well understood phenomenon. However, in vivo, a large number of variables conspire to obscure and confuse. In this article, Nico van Rooijen attempts to bring order to events that occur in the spleen after antigenic challenge: starting with the large body of reliable in vitro data he incorporates information on splenic anatomy, cell trafficking and the cellular microenvironment to arrive at a physiological model for antigen handling in vivo.
authors.affiliation: Dept of Histology, Medical Faculty, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: van Rooijen
mesh_terms: D000818:Animals; D000941:Antigens / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens