title: Penicillamine in systemic sclerosis: a reappraisal.
abstract: In a 36-month prospective trial 21 patients with systemic sclerosis (diffuse systemic sclerosis 16 patients and 5 subjects with limited cutaneous subtype) were treated with D-penicillamine. In all patients with diffuse systemic sclerosis there was objective improvement. The degree and extent of skin involvement decreased significantly (p less than 0.001), whereas no objective improvement was noted in patients with limited cutaneous subtype. Further, no systemic progression of the disease was observed during the study period. Our results suggest that a prolonged treatment with D-penicillamine in small doses is not only beneficial and effective but also free of side-effects, if used at an earlier stage.
authors.affiliation: Department of Medicine, Faculty of Medicine, Kuwait University.
authors.forename: M A
authors.initials: MA
authors.lastname: Sattar
authors.forename: R T
authors.initials: RT
authors.lastname: Guindi
authors.forename: T N
authors.initials: TN
authors.lastname: Sugathan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use*; D012594:Scleroderma, Localized / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D010396:Penicillamine