title: Cardiac and circulatory response to the intravenous administration of urapidil during general anaesthesia.
abstract: The authors have assessed the hypotensive response to the intravenous administration of urapidil bolus, during intra-operative hypertensive crises, in 42 patients undergoing general anaesthesia for surgery. Twenty-two of these patients underwent major vascular surgery and were monitored through catheters introduced into the radial and pulmonary arteries, to study the haemodynamic changes induced by urapidil. A significant reduction was observed in these values: systolic and diastolic arterial pressure, systolic and diastolic pulmonary pressure, pulmonary wedge pressure and systemic vascular resistance. A non-significant reduction was observed in central venous pressure and pulmonary vascular resistance. Heart rate and cardiac output remained unchanged. Systolic arterial pressure decreased 12% from the baseline in 81% of patients. The transient action of urapidil bolus in some cases (55%) suggests the need for urapidil infusion.
authors.affiliation: Service of Anaesthesia, Intensive Care and Antalgic Therapy, S. Corona Hospital, Garbagnate Milanese, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fontana
authors.forename: B
authors.initials: B
authors.lastname: Allaria
authors.forename: B
authors.initials: B
authors.lastname: Brunetti
authors.forename: R
authors.initials: R
authors.lastname: Arienta
authors.forename: M
authors.initials: M
authors.lastname: Favaro
authors.forename: A
authors.initials: A
authors.lastname: Trivellato
authors.forename: M G
authors.initials: MG
authors.lastname: Rusconi
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil