title: GdDTPA-enhanced magnetic resonance imaging of the aqueous flow in the rabbit eye.
abstract: Magnetic resonance imaging with gadolinium-diethylenetriaminepentaacetic acid complex (GdDTPA) as the contrast agent was used to image the aqueous chamber of the eye. This method, in addition to providing spatial information, permits quantitative study of the aqueous flow. GdDTPA solution was applied either topically or intravenously, entering the anterior chamber via different pathways. The wash-in and wash-out of GdDTPA follow a two-compartment model which enables determination of the aqueous flow rate by multiplying the aqueous chamber volume by the wash-out rate constant. Rabbit eyes showed a flow rate of 1.5-2 microliters/min which was retarded by the systemic administration of acetazolamide (Diamox).
authors.affiliation: Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
authors.forename: H M
authors.initials: HM
authors.lastname: Cheng
authors.forename: K K
authors.initials: KK
authors.lastname: Kwong
authors.forename: J
authors.initials: J
authors.lastname: Xiong
authors.forename: C
authors.initials: C
authors.lastname: Chang
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism*; D001082:Aqueous Humor / Q000378:metabolism*; D002924:Ciliary Body / Q000378:metabolism; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity; D003315:Cornea / Q000033:anatomy & histology / Q000378:metabolism; D005682:Gadolinium / Q000008:administration & dosage / Q000633:toxicity; D019786:Gadolinium DTPA; D007275:Injections, Intravenous; D007498:Iris / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009883:Ophthalmic Solutions; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity; D004369:Pentetic Acid / Q000008:administration & dosage / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
chemical_list: D003287:Contrast Media; D009883:Ophthalmic Solutions; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; D000086:Acetazolamide