The effect of immunosuppression with whole body and regional irradiation on the development of cerebral oedema in a rat model of intracerebral haemorrhage.
A lesion simulating intracerebral haemorrhage was produced in the right caudate nucleus of rats immunosuppressed with whole body or regional irradiation. Whole body irradiation produced significant leucopaenia and thrombocytopaenia and conferred protection against cerebral ischaemia and oedema when compared to nonirradiated control animals. Local radiation to the head or torso did not confer protection.
Kane
P J
PJ
Department of Neurosurgery, University of Newcastle Upon Tyne, England.
Modha
P
P
Strachan
R D
RD
Mendelow
A D
AD
Cook
S
S
Chambers
I R
IR
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000150:complications*; D002560:Cerebrovascular Circulation / Q000528:radiation effects; D007165:Immunosuppression Therapy / Q000379:methods*; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014916:Whole-Body Irradiation