[The development of a new generation of pertussis vaccine].
The results of the weight gain test on mice have shown that acellular pertussis vaccine is less toxic than the pertussis component of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine due to a lower content of endotoxin in the acellular vaccine; but the leukocytosis-promoting and histamine-sensitizing activities of JNIH-6 and adsorbed DPT vaccines are indicative of incomplete inactivation of Bordetella pertussis toxin. The content of incompletely inactivated B. pertussis toxin is practically the same in both preparations, constituting 1/100-1/200 of the calculated initial activity. For this reason, the use of the new pertussis vaccine also involves a risk of development of serious postvaccinal reactions and/or complications caused by this toxin. Search for the optimum method of inactivation of B. pertussis main toxin should be continued. As shown by the enzyme immunoassay, acellular pertussis vaccine used in the same immunizing dose as adsorbed DPT vaccine induces a more intensive immune response to hemagglutinin and B. pertussis toxin. This is due to higher residual toxicity of the corpuscular component of adsorbed DPT vaccine. Induction of antibodies to B. pertussis toxin has been shown to decrease in response to injection of acellular pertussis vaccine containing a certain residual amount of incompletely inactivated B. pertussis toxin.
Chuprinina
R P
RP
Bychenko
B D
BD
Smirnov
V D
VD
Maksiutov
R V
RV
Eglit
Iu Kh
IuKh
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D001886:Bordetella pertussis / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006388:Hemagglutinins / Q000276:immunology; D006632:Histamine / Q000276:immunology; D007110:Immunity, Active / Q000187:drug effects / Q000276:immunology; D007114:Immunization; D007964:Leukocytosis / Q000097:blood / Q000139:chemically induced; D051379:Mice; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000276:immunology* / Q000633:toxicity; D013997:Time Factors; D010566:Virulence Factors, Bordetella / Q000276:immunology
D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006388:Hemagglutinins; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; D006632:Histamine; D037342:Pertussis Toxin
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