Long term effects of adult-thymectomy on natural killer activity and spontaneous tumor incidence.
Long term effects of adult-thymectomy on both natural killer (NK) activity and spontaneous tumor incidence were investigated in C57BL/6 mice maintained in specific pathogen free atmosphere. As compared with the age matched sham-thymectomized mice, a substantially low incidence of spontaneous tumour (6%) and a high level of splenic NK activity were noted one and a half year later in C57BL/6 mice thymectomized at 6 weeks of age. In contrast, sham-thymectomized mice showed a high incidence of the spontaneous tumor (57%) associated with a low level of splenic NK activity. These results suggest that NK cells play a critical role to prevent the occurrence of spontaneous tumor in vivo.
Hussain
A
A
Department of Immunology, Kyushu University, Fukuoka, Japan.
Mayumi
H
H
Taniguchi
K
K
Tanaka
K
K
Nomoto
K
K
D000367:Age Factors; D000818:Animals; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000209:etiology*; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*