Distribution of lipid microspheres incorporating prostaglandin E1 to vascular lesions.
The intravascular distribution of 0.2 mu lipid microspheres (LM) containing prostaglandin E1 (lipo-PGE1) injected intravenously in spontaneously hypertensive rats (SHR) and arteriosclerotic rabbits was investigated by electron microscopic observation and quantification of radiolabelled compounds. LM were observed under an electron microscope to concentrate in subendothelial space of vascular walls, particularly in vascular lesions associated with hypertension or arteriosclerosis. Radiolabelled lipo-PGE1 accumulated more densely in the vascular walls than did free PGE1, and the difference was more conspicuous in vascular lesions. This indicates that lipo-PGE1 penetrates vascular endothelium and then accumulates in blood vessels to result in augmentation of the pharmacological action of prostaglandin. These findings suggest the usefulness of LM as a carrier of prostaglandin to vascular lesions.
Mizushima
Y
Y
Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Hamano
T
T
Haramoto
S
S
Kiyokawa
S
S
Yanagawa
A
A
Nakura
K
K
Shintome
M
M
Watanabe
M
M
D000527:Alprostadil / Q000378:metabolism*; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism* / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000150:complications / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004337:Drug Carriers; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008055:Lipids; D008297:Male; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012995:Solubility
D004337:Drug Carriers; D008055:Lipids; D000527:Alprostadil