The effect of gamma-vinyl-GABA on the performance of nucleus basalis-lesioned rats in spatial navigation task.
The present study investigates whether the stimulation of gamma-aminobutyric acid (GABA)ergic system affects spatial navigation deficits induced by the lesioning of the nucleus basalis (NB). Thus, the effect of gamma-vinyl-GABA treatment which elevates the GABA levels in brain was studied on water maze task both in unoperated and NB-lesioned (ibotenic acid) rats. The subchronic administration of gamma-vinyl-GABA aggravated dose-dependently NB lesion-induced deficits, although it did not impair the performance of unoperated rats in this task. The imbalance between GABAergic system and cholinergic or non-cholinergic systems of the NB may contribute to spatial navigation deficits in rats.
Hannila
T
T
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Riekkinen
P J
PJ
D000614:Aminocaproates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007051:Ibotenic Acid / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013028:Space Perception / Q000502:physiology*; D020888:Vigabatrin
D000614:Aminocaproates; D007051:Ibotenic Acid; D020888:Vigabatrin