[A case of inflammatory breast cancer successfully treated with intra-arterial infusion of high-dose epirubicin].
A 56-year-old female with extensive inflammatory breast cancer was treated with intra-arterial infusion chemotherapy using a high dose of epirubicin. One cycle consisted of epirubicin; 150 mg (day 1, 4, 7) and daily administration of tamoxifen; 40 mg. After completion of 2 cycles of the regimen, both the main tumor and the extensive inflammatory skin lesion completely disappeared (CR). Hair loss, gastrointestinal disorders and leukopenia (nadir; 1,600) were the side effects encountered, but all of them were reversible. These findings suggested that dose-escalation of epirubicin was effective, and that cases with extensive skin involvement were also candidates for this modality.
Takatsuka
Y
Y
Dept. of Surgery, Osaka National Hospital, Japan.
Gofuku
J
J
Katoh
T
T
Okamura
Y
Y
Kobayakawa
K
K
Kawahara
T
T
D000284:Administration, Oral; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007249:Inflammation; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D013629:Tamoxifen / Q000008:administration & dosage
D013629:Tamoxifen; D015251:Epirubicin