title: Polyanions inhibit binding of human autoantibodies to certain cellular proteins.
abstract: The effect of polyanions on the reactivity of human autoantibodies with cellular proteins was studied. The results of immunoblotting revealed that dextran sulfate (DS), heparin, single-stranded (ss) DNA, and polyinosinic acid (poly I) inhibit interaction between immunoglobulins (Ig) from human autoimmune sera and many polypeptides with various molecular mass. These proteins were suggested to belong to a new subclass of autoantigens, the immunoreactivity of which is sensitive to the presence of polyanions. For some of these antigens, molecular mass, intracellular localization and frequency of appearance of positive sera were determined.
authors.affiliation: Institute of Medical Radiology, Academy of Medical Sciences of the USSR, Obninsk.
authors.forename: A E
authors.initials: AE
authors.lastname: Kabakov
authors.forename: Y B
authors.initials: YB
authors.lastname: Griaznova
authors.forename: V A
authors.initials: VA
authors.lastname: Saenko
authors.forename: A M
authors.initials: AM
authors.lastname: Poverenny
mesh_terms: D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001323:Autoantibodies / Q000378:metabolism*; D001324:Autoantigens / Q000145:classification / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000276:immunology / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000071228:Polyelectrolytes; D011108:Polymers; D011506:Proteins