title: Developing nonsteroidal anti-inflammatory drugs (NSAIDs) with decreased gastrointestinal (GI) toxicity.
abstract: NSAID-induced gastropathy is an important iatrogenic disorder that must be addressed in the development of NSAIDs. A scheme for clinical evaluation is described and salsalate is discussed as a prototype.
authors.affiliation: Clinical Research, 3M Pharmaceuticals, St. Paul, MN 55144.
authors.forename: B
authors.initials: B
authors.lastname: Goldlust
authors.forename: M
authors.initials: M
authors.lastname: Doucette
authors.forename: C
authors.initials: C
authors.lastname: Verduyn
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000633:toxicity; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal