Evidence that reverse cholesterol transport is stimulated by lipolysis of triglyceride-rich lipoproteins.
The hypothesis that reverse cholesterol transport by high density lipoprotein (HDL) is augmented by lipolysis of triglyceride-rich lipoproteins received support from experiments in rabbits whose tissue cholesterol had been pre-labeled with [3H]cholesterol several weeks earlier. When lipolysis was stimulated by intravenous heparin (which releases lipoprotein lipase from vascular endothelium), reciprocal changes in plasma triglyceride and HDL cholesterol concentrations were accompanied by a rise in the specific radioactivity of HDL cholesterol, indicative of increased transfer of cholesterol into HDL from slowly exchanging cholesterol pools in extra-hepatic tissues.
Miller
N E
NE
Department of Medicine, Bowman Gray School of Medicine, Winston-Salem NC 27103.
Nanjee
M N
MN
D000818:Animals; D001692:Biological Transport; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D004730:Endothelium, Vascular / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D007700:Kinetics; D008066:Lipolysis / Q000502:physiology*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol; D008071:Lipoprotein Lipase