[The use of the ion exchange polymer Wofatit CP for sample preparation of drugs from urine for high pressure liquid chromatographic and spectrophotometric determinations].
The sample preparation of the alkaline drugs dioxopromethazinehydrochloride and trapidil from urine was studied systematically. The weak acid cation exchanger Wofatit CP was used as stationary phase. Batch mode and column chromatographic sample preparation were compared. The usable capacity of the ion exchanger for the analyte is an important characteristic for the sample preparation. The great influence of pH and ionic strength of the sample on the usable capacity was proved.
Witte
P
P
Sektion Chemie, Humboldt-Universität zu Berlin.
Wolff
M
M
D000180:Acrylic Resins; D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000180:Acrylic Resins; D002021:Buffers; D007475:Ion Exchange Resins; D004364:Pharmaceutical Preparations; C067721:wofatit CP
Untersuchungen zum Einsatz des Ionenaustauscherpolymers Wofatit CP bei der Vorbereitung arzneistoffhaltiger Urinproben für hochleistungsflüssigkeitschromatographische und spektrophotometrische Bestimmungen.