Metabolic-endocrine correlates of the lateral hypothalamic syndrome: the first 48 hours.
Mature (224 g) male Sprague-Dawley rats received bilateral electrolytic (1 mA for 8 sec) lesions in the lateral hypothalamic area (LHAL) or sham operations (CON). One group of CON was allowed to eat ad lib (CON-ADLIB), a second CON group was pair-fed to the LHAL rats (CON-PF). Tap water was available ad lib. Two days after the operation/sham operation all rats were killed by decapitation. Body weight, body weight change, food intake, carcass fat, liver weight, epididymal fat pad weight, in vitro incorporation of U-C14-glucose into liver total lipid, glycogen and CO2 (oxidation) (DPM, DPM/mg protein) as well as oxidation in fat pad tissue, plasma glucose and insulin were significantly reduced in LHAL and CON-PF rats compared with CON-ADLIB. Glucose carbon incorporation into epididymal fat pad lipid and glycogen were normal in LHAL and CON-PF. Liver protein and plasma free fatty acids (FFA) were both higher in LHAL and CON-PF than in CON-ADLIB groups. Thus, many of the somatic and metabolic changes that appear in the first few days after lesion production are simply due to hypophagia. However, CON-PF rats also exhibited some significant differences from the LHAL group, i.e., their plasma glucose and incorporation of glucose carbon into liver glycogen (DPM) were significantly lower than in LHAL rats; alternatively, plasma FFA levels were higher in CON-PF than in LHAL rats. Also, liver weight/100 g body weight was lower and fat pad weight/100 g body weight was higher in CON-PF than in LHAL rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Bernardis
L L
LL
Neurovisceral Laboratory, Veterans Administration Medical Center, Buffalo, NY 14215.
Bellinger
L L
LL
Awad
A
A
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D004032:Diet; D004435:Eating / Q000502:physiology; D004702:Endocrine Glands / Q000378:metabolism*; D004822:Epididymis / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007026:Hypothalamic Area, Lateral / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin