[The hygienic validation of the MPEL for the fungicide tekto in reservoir water].
Fungicide tecto (thiabendazol) is a low-toxic compound, produces a weak skin-resorptive and local irritating effect. Cumulation coefficient is 3.96. Threshold and subthreshold doses for tecto were determined as a result of 12-months chronic experiment on white rats--3.7 and 0.37 mg/kg, respectively. The allowable 24-hours dose for human exposure to the chemical is 0.6 mg. The threshold tecto concentration according to the effect on the general sanitary regimen of water reservoirs appeared to be 1 mg/l. According to the limiting toxicological index 0.05 mg/l was recommended as tecto MAC for the water of reservoirs.
Kedrova
I I
II
Balakireva
S I
SI
Kremko
L M
LM
Levoshuk
N P
NP
Kagan
N A
NA
Karaseva
A E
AE
Petrovich
I N
IN
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008452:Maximum Allowable Concentration; D011817:Rabbits; D051381:Rats; D013827:Thiabendazole / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*
D005659:Fungicides, Industrial; D014874:Water Pollutants, Chemical; D013827:Thiabendazole
Gigienicheskoe obosnovanie PDK fungitsida tekto v vode vodoemov.