Effect of abnormal levels of serum components on antibiotic activity.
Antibiotic activity in serum from a model for type II diabetes was similar to that in normal sera or media containing cholesterol but lacking glucose, insulin, or both. The ratio of effects of broth plus obese-rat serum to effects of broth plus lean-rat serum supplemented with cholesterol approached or equaled 1.
Plotkin
B J
BJ
Department of Microbiology, Chicago College of Osteopathic Medicine, Downers Grove, Illinois 60515.
Wright
M
M
Lima
A
A
Gruenberg
L
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood*; D001770:Blood Bactericidal Activity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D006943:Hyperglycemia / Q000097:blood; D006946:Hyperinsulinism / Q000097:blood; D051381:Rats; D011924:Rats, Zucker
D000900:Anti-Bacterial Agents