title: Single-dose prophylaxis in hysterectomies. An interim analysis.
abstract: The efficacy of single-dose prophylaxis with intravenous cefuroxime 1,500 mg plus 500 mg metronidazole in vaginal or abdominal hysterectomies was investigated in a randomized, double-blind, placebo-controlled study, involving 396 evaluable patients. A significant reduction of the number in urinary tract infections was observed in the groups undergoing abdominal hysterectomy or vaginal hysterectomy with vaginal repair. The incidence of wound infections and the duration of hospitalization were significantly reduced in patients undergoing vaginal hysterectomy with or without vaginal repair. Body temperature normalized faster in all three groups receiving peri-operative antibiotic prophylaxis. It is concluded that a single injection of antimicrobial prophylaxis is sufficient and useful in both abdominal and vaginal hysterectomies.
authors.affiliation: Department of Gynaecology and Obstetrics, Medical Centre Alkmaar, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Boodt
authors.forename: W P
authors.initials: WP
authors.lastname: Snijders
authors.forename: R
authors.initials: R
authors.lastname: Janknegt
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002444:Cefuroxime / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005334:Fever / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007045:Hysterectomy, Vaginal / Q000009:adverse effects; D015994:Incidence; D008795:Metronidazole / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000517:prevention & control; D014946:Wound Infection / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002444:Cefuroxime