Atrophy of outer hair cell stereocilia and hearing loss in hydropic cochleae.
We have earlier described selective atrophy of short and middle stereocilia on outer hair cells of the three upper cochlear turns in hydropic cochleae of guinea pigs. The present study describes sequential early stages of stereocilia degeneration leading to this specific atrophy. Comparison of the morpho-pathology with the ultimate CAP audiograms taken before sacrifice indicated a close association between the low frequency hearing loss and this atrophy of stereocilia. The atrophy appeared to be associated first with the short and then the middle stereocilia of the 2nd and 3rd rows of outer hair cells between 0.5 kHz and 2 kHz and with time included the 1st row of all outer hair cells of the upper cochlear turns down to the 8 kHz region.
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Laboratoire d'Audiologie Expérimentale, INSERM Unite 229, Université Bordeaux II, Hôpital Pellegrin, France.
Horner
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D000161:Acoustic Stimulation; D000200:Action Potentials; D000818:Animals; D001284:Atrophy; D001300:Audiometry, Evoked Response; D003053:Cochlear Duct / Q000648:ultrastructure; D004487:Edema / Q000473:pathology* / Q000503:physiopathology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure*; D006319:Hearing Loss, Sensorineural / Q000473:pathology* / Q000503:physiopathology; D008575:Meniere Disease / Q000473:pathology* / Q000503:physiopathology; D008855:Microscopy, Electron, Scanning; D013701:Temporal Bone