[Morphological evaluation of toxic effect of kartolin-2].
Lipid dystrophy, rapid reduction of RNA and glycogen content in the liver of all experimental rats, developing as a result of acute kartolin-2 poisoning testify to an expressed hepatotropic effect of the substance. Alongside with the processes of parenchymal liver cell damage the signs of intracellular regenerating processes--increase of the size of hepatocytes nuclei are detected. Liver protein metabolism disturbances are observed following exposure to kartolin-2 in the acute experiment. Chronic exposure to kartolin-2, and, specifically to its preparation form in the dose 1/100 LD50 cause lipid infiltration, reduction of histochemical indicators of liver glycogen, and RNA content. No-effect doses of kartolin-2 have been determined.
Aĭvazian
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LK
D000818:Animals; D001699:Biometry; D002219:Carbamates / Q000008:administration & dosage / Q000633:toxicity*; D002452:Cell Count / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology; D007620:Karyometry; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D010937:Plant Growth Regulators / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D002219:Carbamates; D010937:Plant Growth Regulators; C068790:kartolin 2
Morfologicheskaia otsenka toksicheskogo deĭstviia preparata kartolina-2.