The effect of the aminosteroid U-78517G on peritumoural brain oedema.
U-78517G belongs to a novel group of compounds-aminosteroids (AS) which are potent inhibitors of central nervous system tissue lipid peroxidation and are devoid of classical glucocorticoid and mineralocorticoid activities. The AS have been found to possess cerebral protective properties against ischaemia, ischaemic oedema, trauma to the cerebrum and spinal cord and in sub-arachnoid hemorrhage. The possible efficacy of U-78517G in attenuating peritumoural oedema was examined in rats harbouring cerebral 9L gliosarcomas. 19 Sprague-Dawley rats were implanted intracranially with 9L gliosarcoma cells. On day 14 post implantation rats were randomized to control (no treatment n = 10) and AS treated animals (n = 9). On day 20 animals were sacrificed and six brain samples per rat were examined for the percentage of water content. Oedema was assessed with the wet/dry weight technique. The AS treated animals were found to have a significant increase in peritumoural oedema (+1.38%, P less than 0.001) possibly related to an increase in cerebral blood flow associated with AS treatment. Further studies are, however, underway to precisely clarify this unexpected observation.
Arbit
E
E
Memorial Sloan-Kettering Cancer Center, New York, New York.
Rubinstein
A
A
DiResta
G
G
Lee
J
J
Ali
F
F
Galicich
J H
JH
D000818:Animals; D001929:Brain Edema / Q000209:etiology*; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D002839:Chromans / Q000494:pharmacology*; D005910:Glioma / Q000150:complications* / Q000473:pathology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured / Q000637:transplantation
D002839:Chromans; D010879:Piperazines; C066382:U 78517F