[Chlorine e6-sensitized photoinhibition of thrombocyte aggregation. Participation of active oxygen forms].
It has been shown that photosensitized action of chlorin e6 (Che6) on platelet-rich plasma leads to platelet aggregation inhibition. Che6-sensitized photoinactivation of platelets was intensified in the presence of singlet oxygen interceptor. The aggregation rate of light-irradiated platelets in the presence of Che6 in D2O buffer was higher than in H2O buffer. The participation of active oxygen forms in the determination of platelet function has been considered.
Samal'
A B
AB
Zorina
T E
TE
Cherenkevich
S N
SN
D002735:Chlorophyllides; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D010100:Oxygen / Q000494:pharmacology*; D010777:Photochemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*; D026082:Singlet Oxygen
D002735:Chlorophyllides; D010975:Platelet Aggregation Inhibitors; D011166:Porphyrins; D026082:Singlet Oxygen; C062985:phytochlorin; D010100:Oxygen
Sensibilizirovannoe khlorinom e6 fotoingibirovanie agregatsii trombotsitov. Uchastie aktivnykh form kisloroda.