Facilitation of protein biosynthesis by ginsenoside-Rb2 administration in diabetic rats.
In streptozotocin-induced diabetic rats given 10 mg/day of ginsenoside-Rb2 for 3 days, there was no significant increase in the serum protein and albumin levels, whereas a significant increase in these parameters was found in rats given the ginsenoside-Rb2 for 6 days. When the state of protein biosynthesis was determined using [14C] leucine, significantly activated protein biosynthesis was found in rats given ginsenoside-Rb2 for 3 days, indicating the presence of an activated state of protein biosynthesis prior to the evident quantitative increase.
Yokozawa
T
T
Department of Applied Biochemistry, Toyama Medical and Pharmaceutical University, Japan.
Oura
H
H
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000096:biosynthesis* / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D036145:Ginsenosides; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*; D012709:Serum Albumin / Q000096:biosynthesis
D001786:Blood Glucose; D001798:Blood Proteins; D036145:Ginsenosides; D012503:Saponins; D012709:Serum Albumin; C048026:ginsenoside Rb2