title: [Synthesis of gallic acid derivatives with L-thiazolidin-4-carboxylic acid and study on their antiradical and antitoxic activity].
abstract: The authors report the synthesis of three new derivatives of gallic acid with L-thiazolidine-4-carboxylic acid. The new compounds were tested for radical scavenger activity against doxorubicin toxicity in mice and for antitoxic activity against acetaldehyde and formaldehyde toxicities in rats. Unlike the utilized standards, the new compounds show no activity.
authors.affiliation: Centro Ricerche, Poli Industria Chimica, Rozzano.
authors.forename: L
authors.initials: L
authors.lastname: Del Corona
authors.forename: G
authors.initials: G
authors.lastname: Signorelli
authors.forename: S
authors.initials: S
authors.lastname: Manzardo
authors.forename: G
authors.initials: G
authors.lastname: Coppi
mesh_terms: D000079:Acetaldehyde / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D000931:Antidotes / Q000138:chemical synthesis* / Q000494:pharmacology; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000633:toxicity; D005557:Formaldehyde / Q000037:antagonists & inhibitors / Q000633:toxicity; D016166:Free Radical Scavengers; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D053778:Thiazolidines
chemical_list: D000931:Antidotes; D016166:Free Radical Scavengers; D013844:Thiazoles; D053778:Thiazolidines; D005557:Formaldehyde; D005707:Gallic Acid; D004317:Doxorubicin; C003438:thiazolidine-4-carboxylic acid; D000079:Acetaldehyde
vernacular_title: Sintesi di derivati dell'acido gallico con l'acido L-tiazolidin-4-carbossilico e studio della loro attività antiradicalica ed antitossica.