[A kindling model of epilepsy induced by intraperitoneal injection of coriaria lactone in rats].
Fifty adult male Sprague-Dawley rats were divided into five groups. Intraperitoneal injections of various doses of coriaria lactone (CL, 0.75, 1.25, 1.75, and 2.0 mg/kg) and normal saline were given respectively per 2 days. The behavior of the rats was observed and the ECoG was recorded by telemetric method. The results of experiments show that a kindling model of epilepsy can be established by intraperitoneal injection of CL in rats. This chronic experimental model is of value for application because it is easily established and the rate of being kindled is relatively high, but the mortality is low, and the kindling effect can last well. The model can avert the pathological change caused by artificial injury to brain, so it is advantageous to the research on neurochemistry and ultrastructure. In our experimental condition, it is optimal to select 1.25 mg/kg or 1.75 mg/kg as the dosage of CL for establishing kindling model.
Tang
Y
Y
Xie
Y
Y
Chai
H
H
Chen
Q
Q
D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007696:Kindling, Neurologic / Q000187:drug effects; D007783:Lactones; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007783:Lactones; C049836:coriaria lactone