Acquired myasthenia gravis. Selective involvement of esophageal, pharyngeal, and facial muscles.
Serum samples from 152 dogs with a clinical diagnosis of idiopathic megaesophagus without detectable generalized muscle weakness were tested for the presence of antibodies to acetylcholine receptors by immunoprecipitation radioimmunoassay. Positive serum antibody titers (mean, 3.1 nmoL/L; range, 0.77-30 nmoL/L; reference values less than 0.6 nmoL/L) were found in 40 dogs (26%), with German Shepherd dogs (8/25, 32%) and Golden Retrievers (7/20, 35%) having a greater percentage of positive submissions. By immunocytochemical methods, localization of immune complexes at the neuromuscular junction after incubation of serum with normal canine muscle was documented in an additional 17 cases (11% of all samples submitted) that did not have increased antibody titers to acetylcholine receptors. Of the 40 seropositive dogs, 17 (48%) had a clinical improvement or remission of clinical signs associated with decreasing AChR antibody titers. Idiopathic megaesophagus has been associated with a poor prognosis; however, this study demonstrates that a large percentage of the dogs have myasthenia gravis and that with supportive treatment, the clinical signs may improve or resolve.
Shelton
G D
GD
Salk Institute for Biological Studies, San Diego, California.
Willard
M D
MD
Cardinet
G H
GH
Lindstrom
J
J
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000097:blood; D001947:Breeding; D004283:Dog Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004285:Dogs; D004931:Esophageal Achalasia / Q000209:etiology / Q000662:veterinary*; D005152:Facial Muscles / Q000503:physiopathology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D009469:Neuromuscular Junction / Q000276:immunology; D010609:Pharyngeal Muscles / Q000503:physiopathology*; D011233:Precipitin Tests; D011379:Prognosis; D011863:Radioimmunoassay; D011950:Receptors, Cholinergic / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D011950:Receptors, Cholinergic