Aneuploid DNA content in pancreatic adenocarcinoma.
DNA content measurements were performed by flow cytometry on eight ductal-type pancreatic adenocarcinomas. The majority of the neoplasms contained an aneuploid DNA content, with hyperdiploid DNA content being the most common abnormality. Two neoplasms had a diploid DNA content. These latter two patients are alive at 11 mo and 3 mo. The data suggest that a large percentage of pancreatic adenocarcinomas have an aneuploid DNA content. Further study is needed to evaluate the relationship between aneuploid DNA content and survival.
Wido
T M
TM
Department of Pathology, Medical College of Ohio, Toledo 43699.
Myles
J L
JL
Pisharodi
L
L
Sawyer
T
T
Kim
K
K
Gohara
A F
AF
Howard
J M
JM
D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000401:mortality; D011379:Prognosis
D004273:DNA, Neoplasm