[Interaction between diltiazem and sevoflurane in the canine blood-perfused papillary muscle and sinoatrial node preparations].
Experiments were carried out on 17 canine isolated cardiac tissue preparations perfused by arterial blood from donor dogs. Diltiazem was continuously infused i.v. into the conscious (10 dogs) and the sevoflurane anesthetized (2.36%, 7 dogs) donor dogs at a rate of 20 micrograms.kg-1.min-1 for 60 minutes. The changes induced by diltiazem were normalized by the values at the start of diltiazem infusion, and the comparison was made between the two groups. 1) The decrease in heart rate and increase in PQ interval were smaller in conscious dogs than in the anesthetized dogs. 2) Decrease in developed tension in conscious state was smaller than that during sevoflurane anesthesia. 3) There was no significant difference in the decrease in blood pressure or sinoatrial rate between the conscious group and the anesthetized group. These results indicate that sevoflurane anesthesia removes the compensatory reflex which is present in the conscious state and also increases cardiovascular depressant effects of diltiazem.
Ookawa
I
I
Department of Anesthesiology, Yamanashi Medical College.
Manabe
M
M
Yamaguchi
T
T
Motomura
S
S
Kumazawa
T
T
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004110:Diltiazem / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D004987:Ethers / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008738:Methyl Ethers; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004110:Diltiazem