[Activity of alveolar macrophages of experimental lung cancer and inhibition of cell proliferation].
Alveolar macrophages (AM) from rats with lung cancer induced by 3,4-benzo(a)pyrene were collected and examined under SEM. According to changes of the surface ultrastructure, AMs were classified into activated and unactivated groups. Different groups of cells were incubated with Hela cells as the target, and cytostatic activity of AM was studied in vitro, including observation of the morphological changes as well as determination of the cytostatic index (CI). Results showed that AMs from non-tumor-bearing and control groups had spontaneous cytotoxicity, which might be related to the existence of a certain proportion of activated macrophages in the host, while the activity of AM from the tumor-bearing group was obviously inhibited.
Shen
B H
BH
Department of Pathology, China Medical University, Shenyang.
He
M C
MC
D000818:Animals; D001564:Benzo(a)pyrene; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D003602:Cytotoxicity, Immunologic; D006367:HeLa Cells; D008175:Lung Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D011650:Pulmonary Alveoli / Q000648:ultrastructure; D051381:Rats; D014407:Tumor Cells, Cultured
D001564:Benzo(a)pyrene