An alternative point of view on experimental lung hyperreactivity.
The booster injection of antigen to pre-sensitized guinea-pigs induces lung modifications leading to hyperresponsiveness and to shifts in the profile of the effective drugs. The introduction of the concept of lung inflammation offers new targets for drug discovery.
Desquand
S
S
Unité de Pharmacologie cellulaire, Unité Associée Institut Pasteur-INSERM n 285, Paris, France.
Pretolani
M
M
Lefort
J
J
Vargaftig
B B
BB
D000818:Animals; D000941:Antigens / Q000276:immunology; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000473:pathology; D007114:Immunization; D007117:Immunization, Secondary; D066298:In Vitro Techniques; D007249:Inflammation / Q000473:pathology; D008168:Lung / Q000276:immunology / Q000503:physiopathology*; D008954:Models, Biological; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*
D000941:Antigens