Pseudosemiglabrin, a platelet aggregation inhibitor from tephrosia semiglabra.
Following bioassay-directed fractionation procedures, two 7-oxygenated-8-prenylflavones, (-)-pseudosemiglabrin [1] and (-)-semiglabrin [2], were isolated from an MeOH extract of Tephrosia semiglabra. (-)-Pseudosemiglabrin [1] displayed in vitro inhibitory effects on human platelet aggregation.
Jonathan
L T
LT
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
Gbeassor
M
M
Che
C T
CT
Fong
H H
HH
Farnsworth
N R
NR
Le Breton
G C
GC
Venton
D L
DL
D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification; D011450:Prostaglandin Endoperoxides, Synthetic
D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; C068536:pseudosemiglabrin