A simple and rapid method for the estimation of quinine using reversed-phase high-performance liquid chromatography with UV detection.
A method for measurement of quinine by high-performance liquid chromatography with detection by absorbance at 240 nm is described. The method is sensitive and free from analytical interferences from other drugs, including the quinine diastereoisomer quinidine. Data obtained by analysis of serum from a patient who took a quinine overdose are reported, and the results are compared to those obtained with a spectrofluorometric method.
Galloway
J H
JH
Department of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Marsh
I D
ID
Forrest
A R
AR
D000293:Adolescent; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006736:Horses; D006801:Humans; D008297:Male; D011803:Quinine / Q000097:blood* / Q000506:poisoning; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D011803:Quinine