title: Exit-site care and exit-site infection in continuous ambulatory peritoneal dialysis (CAPD): results of a randomized multicenter trial.
abstract: A total of 127 patients from 8 hospitals were randomized into 1 of 2 exit-site care regimes to evaluate their effect on rate of exit-site infection (ESI). Group 1 used povidone iodine and nonocclusive dressings changed 2 to 3 times weekly; Group 2 simply cleansed the exit site with nondisinfectant soap and water. Incidence, cause, duration, and treatment of ESI and peritonitis (P) were noted. Groups were analysed for age, sex, end-stage renal disease (ESRD), catheter, and systems. Total cumulative follow up time was 95.6 years. There was a significantly higher rate (p = 0.0183) of ESI in Group 2 (soap and water). The mean rate of ESI was 0.27 episodes/patient year for Group 1 versus 0.71 episodes/patient year for Group 2. Rates of P for the two groups were not significantly different (p greater than 0.50): 0.446 episodes/year for Group 1 versus 0.574 episodes/year for Group 2. S. aureus was responsible for 83% of ESI in Group 1 and 67% of ESI in Group 2. Protective dressing with a disinfectant is associated with significantly less ESI than minimum care. However, further research in exit-site care aimed specifically at reducing S. aureus infection is still required.
authors.affiliation: Baxter R&D Europe, Nivelles, Belgium.
authors.forename: M A
authors.initials: MA
authors.lastname: Luzar
authors.forename: C B
authors.initials: CB
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Balf
authors.forename: L
authors.initials: L
authors.lastname: Hill
authors.forename: B
authors.initials: B
authors.lastname: Issad
authors.forename: B
authors.initials: B
authors.lastname: Monnier
authors.forename: J
authors.initials: J
authors.lastname: Moulart
authors.forename: J C
authors.initials: JC
authors.lastname: Sabatier
authors.forename: J P
authors.initials: JP
authors.lastname: Wauquier
authors.forename: F
authors.initials: F
authors.lastname: Peluso
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D001458:Bandages; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011206:Povidone-Iodine / Q000627:therapeutic use*; D012915:Soaps; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D012915:Soaps; D011206:Povidone-Iodine