[Effects of enflurane on the elastic properties of frog skinned skeletal muscle fiber under relaxed and rigor conditions].
We studied the effects of enflurane on the elastic property of the mechanical skinned fiber prepared from M. Semitendinosus of bullfrog. Longitudinal and lateral elastic properties of the skinned fibers were measured under relaxed and rigor conditions to clarify the effects of enflurane on actomyosin complex. Under the rigor condition, enflurane did not change the lateral elasticity of the fibers, but enflurane decreased the longitudinal elasticity. On the other hand, under the relaxed condition, enflurane did not change the elasticity. The results suggest that enflurane probably decreases the force of binding of cross-bridges to actin, which is one of the factors to reduce the maximal force.
Nishiwaki
T
T
Department of Oral and Maxillofacial Surgery, Gifu University School of Medicine.
Miyagishima
T
T
Sakai
H
H
Oka
N
N
Dohi
S
S
Yamamoto
M
M
D000818:Animals; D004548:Elasticity / Q000187:drug effects; D004737:Enflurane / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000502:physiology*; D009127:Muscle Rigidity / Q000503:physiopathology*; D009132:Muscles / Q000187:drug effects*; D011892:Rana catesbeiana
D004737:Enflurane