Threshold to elicit seizures by picrotoxin is lowered in pentylenetetrazol-kindled mice.
The convulsant effect of different doses of picrotoxin was investigated in pentylenetetrazol-kindled and saline-treated mice. The percentage of convulsions was greater in the kindled mice, compared to controls.
Grecksch
G
G
Institute for Pharmacology and Toxicology, Medical Academy Magdeburg, GDR.
Becker
A
A
Matthies
H
H
D000818:Animals; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010852:Picrotoxin / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D010433:Pentylenetetrazole; D010852:Picrotoxin