Progesterone administration by nasal spray.
The bioavailability and the clinical usefulness of the P administered by nasal spray were investigated. Ten healthy menopausal women received an IN spray administration (4 doses of an oleic P solution 20 mg/mL, corresponding to nearly 11.2 mg of P) and the circulating P levels were calculated. Sixty minutes after administration, the maximum concentration (CMax, 3.75 +/- 0.214 ng/mL) was reached. High P levels (greater than 2 ng/mL) lasted until 360 minutes, and the AUC 0 to 720 was 1,481.6 +/- 343 ng.h/mL. Progesterone administration by spray formulation has proven to be effective in reaching therapeutic levels and to be acceptable to patients and, probably, clinically safe.
Cicinelli
E
E
Department of Obstetrics and Gynecology, Medical School, University of Bari, Italy.
Ragno
G
G
Cagnazzo
I
I
Fanelli
F
F
Vetuschi
C
C
Schonauer
S
S
D000042:Absorption; D000281:Administration, Intranasal; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics
D011374:Progesterone