title: Ultrastructure of an anaplastic giant cell tumor of the thyroid.
abstract: A case of anaplastic, multinucleated giant cell tumor of the thyroid was studied by light and electron microscopy. The coexistence of anaplastic sarcomatous tumor and well differentiated follicular carcinoma, and the presence of desmosomes among the mononuclear cells suggested that this tumor originates in thyroid follicular cells. The multinucleated giant cells, which characterize this thyroid tumor, appeared to be formed by fusion of follicular carcinoma cells and mononuclear epithelial cells, and not by nuclear division without cytoplasmic division.
authors.affiliation: Pathology Section, Kanazawa University Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: T
authors.initials: T
authors.lastname: Michigishi
authors.forename: A
authors.initials: A
authors.lastname: Nonomura
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: F
authors.initials: F
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005870:Giant Cell Tumors / Q000473:pathology / Q000648:ultrastructure*; D015726:Giant Cells / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D013964:Thyroid Neoplasms / Q000473:pathology / Q000648:ultrastructure*