title: Multiple growth abnormalities in vascular smooth muscle from spontaneously hypertensive rats.
abstract: 1. In tissue culture the growth characteristics of aortic smooth muscle cells isolated from spontaneously hypertensive rats (SHR) were compared with those of normotensive Wistar-Kyoto (WKY) rats. 2. Aortic smooth muscle cells from SHR exhibit enhanced proliferation when grown in the presence of low (1%) and moderate (5%) concentrations of fetal calf serum. 3. Cell quiescence in cultures of smooth muscle from SHR becomes apparent at cell densities approximately 20% higher than in cultures from WKY rats. 4. These different growth characteristics of smooth muscle between the two strains of rats may contribute to the early pre-hypertensive development of vascular hypertrophy in the SHR.
authors.affiliation: Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Saltis
authors.forename: P
authors.initials: P
authors.lastname: Little
authors.forename: A
authors.initials: A
authors.lastname: Bobik
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000254:growth & development; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D006130:Growth Disorders / Q000503:physiopathology; D024510:Muscle Development; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000254:growth & development; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY