Induction of IL-1 by lipopolysaccharide (LPS) and its modulation by synthetic lipid A precursor Ia.
The synthetic precursor Ia of lipid A (compound 406), lacking dodecanoic and tetradecanoic fatty acids, is inactive in inducing IL-1, but is able to modulate the production and the release of LPS-induced IL-1.
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Department of Immunology and Cell Biology, Forschungsinstitut Borstel, FRG.
D006017:Glycolipids / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007700:Kinetics; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*
D006017:Glycolipids; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; C040142:lipid A precursors, bacterial