[Current status of pancreas transplantation].
Today, combined kidney and pancreas transplantation is the best treatment for patients with type I diabetes and pre-end or end-stage renal disease due to the diabetic nephropathy. Twenty-nine patients underwent that procedure at our Institution. Recent technical modifications--with the use of a whole pancreas graft with urinary drainage of the exocrine secretion in the recipient by performing a pancreatico-duodeno-cystostomy--allow the monitoring of the exocrine secretion which is a pertinent immunological marker for pancreas rejection. In the next future, pancreas alone should be considered safely using the same procedure, in non uremic diabetic recipients in whom extra-renal secondary complications are more serious than the potential side effects of chronic immunosuppression. That type of pancreas transplantation should benefit of the forthcoming immunosuppressive drugs.
Squifflet
J P
JP
Service de Transplantation Rénale et Pancréatique, Cliniques Universitaires St. Luc, Bruxelles, Belgique.
Gianello
P
P
Pacetti
G
G
Alexandre
G P
GP
D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D004386:Duodenum / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation; D016035:Pancreas Transplantation / Q000379:methods; D001743:Urinary Bladder / Q000601:surgery
Etat actuel de la transplantation pancréatique.