Stability of a novel dithranol ointment formulation, containing ascorbyl palmitate as an anti-oxidant.
An emulsifying ointment-based dithranol formulation is described which was, with the addition of 0.1% w/w ascorbyl palmitate, stable for 52 weeks at room temperature. This is in contrast to the more conventionally used dithranol in Lassar's paste, which is stable for only 4 weeks at room temperature. An emulsifying ointment-based paste was additionally more convenient to use since it was easier to apply and remove.
Weller
P J
PJ
Pharmacy Department, Northwick Park Hospital, Harrow, Middlesex, U.K.
Newman
C M
CM
Middleton
K R
KR
Wicker
S M
SM
D000875:Anthralin / Q000008:administration & dosage*; D000975:Antioxidants; D001205:Ascorbic Acid / Q000031:analogs & derivatives*; D004355:Drug Stability; D009824:Ointments
D000975:Antioxidants; D009824:Ointments; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid; D000875:Anthralin