Flow injection of lithium ion using chromogenic 14-crown-4 derivatives as extraction-spectrophotometric reagents.
A system for flow injection of Li+ has been designed, with use of proton-dissociable chromogenic 14-crown-4 derivatives as the extraction-spectrophotometric reagents, and the analytical conditions have been optimised. This flow injection system showed high selectivity for Li+ reflecting the cation-complexing property of the chromogenic crown ethers. The determination of Li+ in the clinical range in blood under a high Na+ background of 130-160 mM was feasible, with a small sample size (50 microliters) and high sampling rate (more than 100 injections per hour), with this method. The proposed extraction-spectrophotometric flow injection system was, therefore, found to be promising for the efficient determination of Li+ in biological samples, such as blood sera, with a high Na+ background.
Kimura
K
K
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Japan.
Iketani
S
S
Sakamoto
H
H
Shono
T
T
D001322:Autoanalysis / Q000379:methods / Q000592:standards; D002863:Chromogenic Compounds; D004988:Ethers, Cyclic; D006863:Hydrogen-Ion Concentration; D008094:Lithium / Q000097:blood*; D012964:Sodium / Q000097:blood; D013053:Spectrophotometry
D002863:Chromogenic Compounds; D004988:Ethers, Cyclic; D008094:Lithium; D012964:Sodium