Infection of human gastrointestinal cells by HIV-1.
Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.
Moyer
M P
MP
Department of Surgery, University of Texas Health Science Center, San Antonio.
Huot
R I
RI
Ramirez
A
A
Joe
S
S
Meltzer
M S
MS
Gendelman
H E
HE
D002478:Cells, Cultured; D003106:Colon / Q000382:microbiology*; D003588:Cytopathogenic Effect, Viral; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000166:cytology / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology*; D013997:Time Factors; D014779:Virus Replication