Interstrand DNA-platinum-DNA/cross-links induced by cis- and trans-diamminedichloroplatinum(II) at elevated temperature.
Trans-diamminedichloroplatinum(II) (trans-DDP) forms with DNA at 37 degrees C, more numerous interstrand cross-links than cis-DDP in the isolated DNA and DNA in the chromatin complex. An increase in the temperature to 42.5 degrees C had no effect on the interstrand cross-links of DND-Pt-DNA formed by the two isomers, both in DNA and in chromatin.
Kulamowicz
I
I
Department of Molecular Genetics, University of Lódź, Poland.
Walter
Z
Z
Krupa
R
R
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D002945:Cisplatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism; D013053:Spectrophotometry; D013552:Swine; D013816:Thermodynamics
D002843:Chromatin; D004247:DNA; D002945:Cisplatin