Synthesis and in vitro activity of new cephalosporin derivatives containing a benzoxazolone ring.
New cephalosporin derivatives containing a benzoxazolone ring in the side acylamino chain are synthesized using chlorides of non-substituted and halogen substituted (2-benzoxazolone-3-yl) acetic acids for the acylation of the 7-aminodesacetoxy-cephalosporanic acid and 7-amino-cephalosporanic acid amino group. Some of these new compounds exhibit a biological activity higher than that of cephalexin and cephazolin against clinical strains of Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus group A and B.
Kalcheva
V
V
Department of Chemistry, University of Sofia, Bulgaria.
Mincheva
Z
Z
Andreeva
P
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001424:Bacterial Infections / Q000382:microbiology; D002437:Cefazolin / Q000494:pharmacology; D002506:Cephalexin / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002437:Cefazolin; D002506:Cephalexin