title: [Willebrand's factor, functional activity of blood platelets and antiaggregation activity of the vascular wall in ischemic heart disease].
abstract: Fifty coronary male patients aged 34 to 63 (the mean age 46) and 32 normal male subjects aged 18 to 32 (mean age 23) were examined for the levels of Willebrand's factor, induced platelet aggregation, beta-thromboglobulin, thromboxane, prostacyclin levels, and vascular wall antiaggregation activity (by the cuff test). Basing on literature data and their own findings the authors come to a conclusion that elevated plasma concentration of Willebrand's factor combined with increased functional activity of platelets and reduced vascular wall antiaggregation activity is the key factor in the pathogenesis of atherosclerosis development and progress.
authors.forename: M V
authors.initials: MV
authors.lastname: Baluda
authors.forename: V P
authors.initials: VP
authors.lastname: Baluda
authors.forename: I V
authors.initials: IV
authors.lastname: Novikova
authors.forename: I I
authors.initials: II
authors.lastname: Deianov
authors.forename: A V
authors.initials: AV
authors.lastname: Timofeeva
authors.forename: V M
authors.initials: VM
authors.lastname: Fomina
authors.forename: V K
authors.initials: VK
authors.lastname: Filonov
authors.forename: V P
authors.initials: VP
authors.lastname: Emtseva
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor
vernacular_title: Faktor Villebranda, funktsional'naia aktivnost' trombotsitov i antiagregatsionnaia aktivnost' stenki sosudov pri ishemicheskoĭ bolezni serdtsa.