Serum amyloid A levels in acute graft-versus-host disease in bone marrow transplant recipients.
We studied serum amyloid A levels of 31 bone marrow transplant recipients with and without acute graft-versus-host disease. Before transplantation the mean SAA concentration was 5.1 +/- 0.8 mg/l (mean +/- SEM). It remained low in patients with no signs of aGVHD but increased significantly during aGVHD to 54.0 +/- 8.2 mg/l (p less than 0.001 compared to pre-BMT value). Severe infections also induced high SAA levels.
Leskinen
R
R
Transplantation Laboratory, University of Helsinki, Finland.
Maury
C P
CP
Teppo
A M
AM
Volin
L
L
Ruutu
T
T
Häyry
P
P
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000276:immunology*; D006086:Graft vs Host Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D000685:Serum Amyloid A Protein / Q000032:analysis*
D000305:Adrenal Cortex Hormones; D000685:Serum Amyloid A Protein