Effect of a high dose of cimetidine on biliary, intestinal and fecal bile acids in rats.
Effect of an intraperitoneal injection of cimetidine at a daily dose of 160 mg/kg for two weeks on biliary lipid secretion, fecal excretion of bile acids and intestinal bile acids was studied in rats. Bile flow, biliary lipid secretion and fecal excretion of bile acids remained unchanged, while the pool size of bile acids decreased by cimetidine treatment. Chenodeoxycholic acid increased with a concomitant decrease of beta-muricholic acid in the biliary bile acid composition of cimetidine-treated rats.
Imai
Y
Y
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Kawata
S
S
Uchida
K
K
Tarui
S
S
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002927:Cimetidine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate
D001647:Bile Acids and Salts; D002927:Cimetidine