[Proliferation kinetics in rat urothelium after unilateral nephrectomy and various doses of dibutylnitrosamine application--an example of the roles of a one kidney state on carcinogenesis].
We investigated the proliferation of urothel of the rat after unilateral nephrectomy and application of DBN with drinking water in various doses. We controlled the measurement of proliferation with 3H-thymidine. The important results of our experiments with DBN-application and unilateral nephrectomy were: 1. the tumour-incidence is higher and 2. the tumour-appear is earlier than in experiments with only DBN.
Theuring
F
F
Institut für Pathologische Anatomie, Medizinischen Akademie Magdeburg.
Balint
C
C
Meier
W
W
D000818:Animals; D001345:Autoradiography / Q000379:methods; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D009392:Nephrectomy; D009602:Nitrosamines; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D001743:Urinary Bladder / Q000166:cytology / Q000187:drug effects / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; D014316:Tritium; C012279:dibutylnitrosamine; D013936:Thymidine
Proliferationskinetische Untersuchungen am Rattenurothel nach unilateraler Nephrektomie und unterschiedlich dosierter dibutylnitrosamin-Applikation--Ein Beitrag zur Rolle der Einnierigkeit für die Kanzerogenese.