title: 5-Fluorouracil derivatives. XX. Synthesis and antitumor activity of 5'-O-unsaturated acyl-5-fluorouridines.
abstract: Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-pentenoyl derivative showed the highest antitumor activity.
authors.affiliation: Department of Resources Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Kumegawa
authors.forename: T
authors.initials: T
authors.lastname: Nagase
authors.forename: N
authors.initials: N
authors.lastname: Uehara
authors.forename: A
authors.initials: A
authors.lastname: Hoshi
mesh_terms: D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil