Chromosomal assignment and physical linkage of the human C8 loci: implications regarding C8 polymorphisms and deficiencies.
cDNA probes specific for the alpha, beta and gamma subunits of human C8 were used to establish that genes encoding alpha and beta are physically linked and in a 5' alpha-beta 3' orientation on chromosome 1. The gene encoding the gamma subunit was mapped to chromosome 9q. These results explain the close genetic linkage between alpha-gamma and beta on chromosome 1 and indicate that alpha-gamma polymorphisms detected in earlier genetic studies are determined solely by alpha. Results summarized in this report were presented at the VIth Complement Genetics Workshop and Conference (Mainz, FRG, 1989).
Snider
J V
JV
Department of Chemistry, University of South Carolina, Columbia.
Kaufman
K M
KM
Sodetz
J M
JM
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002899:Chromosomes, Human, Pair 9; D003185:Complement C8 / Q000172:deficiency / Q000235:genetics*; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D046911:Macromolecular Substances; D011110:Polymorphism, Genetic
D003185:Complement C8; D046911:Macromolecular Substances; D004247:DNA