Effect of schisanhenol on the antitumor activity of adriamycin.
Schisanhenol (Sal) did not diminish the antitumor activity of adriamycin in mice bearing P388 ascites tumor. Sal did not antagonize the suppressive effect of adriamycin on DNA synthesis and cell proliferation in an L1210 ascitic tumor cell culture. Furthermore, Sal at the concentration of 0.1, 0.25, or 1 mM accelerated adriamycin-dependent DNA damage in the presence of Fe3+ in vitro. It appears that Sal was able to protect against adriamycin induced heart mitochondrial toxicity, while it did not antagonize the antitumor activity of adriamycin.
Lin
T J
TJ
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Liu
G T
GT
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D034242:Cyclooctanes; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011083:Polycyclic Compounds / Q000494:pharmacology / Q000627:therapeutic use*
D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D011083:Polycyclic Compounds; D004317:Doxorubicin; C045309:schisanhenol