[Changes in enzyme systems and lipogenesis metabolites in experimental tuberculosis].
Lung tissue phospholipid metabolism has been studied under the conditions of experimental tuberculosis. These investigations were combined with the simultaneous studying of the qualitative and quantitative composition of individual phospholipids, of the changes in the content of glycerophosphate and dioxiacetonphosphate, as well as, of the abnormalities in the activity of glycerokinase and glycerophosphatedehydrogenase, which play an important role in the catalysis of the initial processes of phosphatidogenesis. Our data obtained have shown that formation of tuberculosis process is accompanied by the pronounced increase of glycerokinase and glycerophosphatedehydrogenase activities, which leads to the significant accumulation of the dioxiacetonphosphate and the free glycerol concentrations. It was established by us, that under the conditions of the pathology studied, the significant decrease of the quantity of phosphatidylcholines, phosphatidylethanolamines and phosphatidylserines took place, while the level of sphingomyelins was increased. The results of our investigations shed the light on the up-to-date understanding of the role of different fractions of phospholipids, as well as, of corresponding enzymatic systems in the pathogenesis of lung tuberculosis and in the formation of focus of necrosis in lung tissue.
Karegezian
K G
KG
Safarian
M D
MD
D000818:Animals; D004099:Dihydroxyacetone Phosphate / Q000032:analysis; D005991:Glycerol Kinase / Q000032:analysis; D005993:Glycerolphosphate Dehydrogenase / Q000032:analysis; D005994:Glycerophosphates / Q000096:biosynthesis; D006168:Guinea Pigs; D008055:Lipids / Q000096:biosynthesis*; D008168:Lung / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D010743:Phospholipids / Q000096:biosynthesis; D014397:Tuberculosis, Pulmonary / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D005994:Glycerophosphates; D008055:Lipids; D010743:Phospholipids; D004099:Dihydroxyacetone Phosphate; D005993:Glycerolphosphate Dehydrogenase; D005991:Glycerol Kinase
Izmenenie nekotorykh fermentnykh sistem i metabolitov lipogeneza pri éksperimental'nom tuberkuleze.