Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models.
The steroid-saving activity of the highly potent new non-steroid antiinflammatory agent CGP 28238 was determined in rat carrageenin paw edema and in primary phase of adjuvant arthritis in comparison with indomethacin. Both nonsteroidal agents showed independent synergistic effects with dexamethasone. Thereby, both compounds reduced the dose of the glucocorticoid necessary for equieffective inhibition of inflammation in the same dose range.
Hirschelmann
R
R
Sektion Pharmazie, Martin-Luther-Universität Halle-Wittenberg, DDR.
Pöch
G
G
Rafler
I
I
Rickinger
O
O
Giessler
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000503:physiopathology; D003907:Dexamethasone / Q000494:pharmacology; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007189:Indans / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans; D003907:Dexamethasone; C059178:flosulide; D007213:Indomethacin