title: [The effect of the aminopeptidase inhibitor bestatin on the enkephalin level in the rat brain].
abstract: Met- and leu-enkephalin contents in midbrain (including hypothalamus) and striatum of rats were determined by radioimmunoassay after bestatin (racemate) injection (200 g, i.c.v.). It was found that bestatin administration influenced the midbrain met-enkephalin content, values and directions of the changes observed being dependent upon the time after the injection. The data obtained confirm the participation of aminopeptidase in enkephalin inactivation and present evidence for the possibility of regional variations of enkephalin catabolism pathways in the brain.
authors.forename: N A
authors.initials: NA
authors.lastname: Beliaev
authors.forename: E F
authors.initials: EF
authors.lastname: Kolesanova
authors.forename: L F
authors.initials: LF
authors.lastname: Kelesheva
authors.forename: T V
authors.initials: TV
authors.lastname: Rotanova
authors.forename: L F
authors.initials: LF
authors.lastname: Panchenko
mesh_terms: D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000187:drug effects / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000187:drug effects / Q000378:metabolism; D004745:Enkephalins / Q000187:drug effects* / Q000378:metabolism; D007276:Injections, Intraventricular; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051381:Rats
chemical_list: D004745:Enkephalins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D000626:Aminopeptidases; D007930:Leucine; C012211:ubenimex; D004121:Dimethyl Sulfoxide
vernacular_title: Vliianie ingibitora aminopeptidaz bestatina na uroven' énkefalinov v mozge krys.