title: [The competitive relations of tamoxifen and estradiol at the level of the plasma membranes of the target cells].
abstract: The specific binding of an antiestrogen tamoxifen to receptors of estradiol of target cells plasmic membranes of the human endometrium was studied in some hyperplastic processes. The relative binding activity of tamoxifen was determined. Tamoxifen was found to compete with estradiol for binding to plasmic membranes of the endometrial cells.
authors.forename: E N
authors.initials: EN
authors.lastname: Mineeva
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D001667:Binding, Competitive / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D004715:Endometriosis / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism; D004958:Estradiol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011127:Polyps / Q000378:metabolism; D011959:Receptors, Estradiol / Q000378:metabolism*; D013629:Tamoxifen / Q000493:pharmacokinetics*; D014594:Uterine Neoplasms / Q000378:metabolism
chemical_list: D011959:Receptors, Estradiol; D013629:Tamoxifen; D004958:Estradiol
vernacular_title: Issledovanie konkurentnykh otnosheniĭ tamoksifena i éstradiola na urovne plazmaticheskikh membran kletok-misheneĭ.