title: Heparin by alternative routes of administration.
abstract: In a study investigating the bioavailability of heparin administered by different routes, we also compared its bioavailability in the dog after oral administration of two enteric-coated formulations, one containing a heparin preparation (ITF-300) and the other sodium heparin. After administration of the formulation containing sodium heparin, there was no heparin in plasma, but when the formulation containing ITF-300 was given, plasma heparin levels were detectable.
authors.affiliation: Department of Pharmacology, Italfarmaco Research Center, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Andriuoli
authors.forename: M
authors.initials: M
authors.lastname: Bossi
authors.forename: I
authors.initials: I
authors.lastname: Caramazza
authors.forename: G
authors.initials: G
authors.lastname: Zoppetti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001681:Biological Assay; D004285:Dogs; D006493:Heparin / Q000008:administration & dosage*; D008297:Male; D013608:Tablets, Enteric-Coated
chemical_list: D013608:Tablets, Enteric-Coated; D006493:Heparin