title: Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in semi-immune children in Zaria, northern Nigeria.
abstract: The World Health Organization (WHO) extended field test was employed to assess the in vivo sensitivity of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in 44 children in Zaria urban area. 36 children (82%) were fully sensitive to the drug and 8 (18%) were resistant at the RI level. 8 parasite isolates were obtained from the children and successfully cultured in vitro using the WHO microtest (mark II) system. The 8 isolates underwent schizogony at concentrations of 10,000 pmol sulfadoxine/125 pmol pyrimethamine per well, indicating in vitro resistance.
authors.affiliation: Department of Pharmacology, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: L
authors.initials: L
authors.lastname: Lege-Oguntoye
authors.forename: S I
authors.initials: SI
authors.lastname: Adagu
authors.forename: B
authors.initials: B
authors.lastname: Werblinska
authors.forename: W N
authors.initials: WN
authors.lastname: Ogala
authors.forename: A B
authors.initials: AB
authors.lastname: Slotboom
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004351:Drug Resistance; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008288:Malaria / Q000188:drug therapy*; D009549:Nigeria; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine