Detection of antisperm-antibodies in patients with primary testicular cancer.
Serum antisperm-antibodies have been noted to develop as a result of various types of testicular pathology and injury. Their presence sometimes correlates with impaired fertility. We examined 52 patients with non-seminomatous low-stage testicular cancer for the presence of serum antisperm-antibodies to determine whether or not auto-immunity is a factor in the depressed fertility known to exist in these patients. Twenty-one per cent were discovered to have serum antisperm-antibodies using an immunofluorescent technique.
Foster
R S
RS
Department of Urology, Indiana University School of Medicine, Indianapolis 46202-5250.
Rubin
L R
LR
McNulty
A
A
Bihrle
R
R
Donohue
J P
JP
D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005298:Fertility; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D009919:Orchiectomy; D013094:Spermatozoa / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery
D001323:Autoantibodies