[Plasma proteins in the early postoperative course after liver transplantation].
The levels of fibronectin, alpha-1 antitrypsin, and fibrinogen have been studied in 34 patients after orthotopic liver transplantation (OLT). Patients were grouped according to A: postoperative course without complications (n = 18), B: development of sepsis accompanied by organ insufficiency (n = 8), and C: acute rejection (n = 6). The plasma levels of alpha-1 antitrypsin and fibrinogen did not show a typical pattern with respect to the postoperative course. The levels of fibronectin, however, did respond to the postoperative events. Starting from a subnormal level a significant increase was observed in group A (p less than 0.005) and C (p less than 0.05) whereas in group B plasma levels remained low. Significant differences (p less than 0.05) were found on day 3 and 5 between group A and C and group B and C. At the end of the observation period survivors (group A and C) had significantly higher levels of fibronectin than nonsurvivors (group B). Therefore fibronectin might aid to diagnose immunologic disturbances after OLT.
Schindler
I
I
Klinik für Anästhesie und Allgemeine Intensivmedizin, I. Chirurgischen Universitätsklinik Wien.
Lackner
F
F
Kiener
F
F
Steininger
R
R
Graninger
W
W
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000502:physiology; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D011183:Postoperative Complications / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D018805:Sepsis / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D001798:Blood Proteins; D005353:Fibronectins; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen
Plasmaproteine im frühen postoperativen Verlauf nach Lebertransplantation.