[Anti-beta-lactoglobulin antibodies as an index of increased intestinal permeability in celiac disease].
IgG antibodies to beta-lactoglobulin (ABLG) were assayed in children with coeliac disease (20 at gluten-containing diet and 35 at gluten-free diet) and in 28 "gastrointestinal" controls. Pathologic levels of ABLG were found in 16 patients with active coeliac disease (80%). In these patients the ABLG mean value was significantly higher than that found in the controls (p less than 0.001). In coeliac subjects at gluten-free diet, normal levels of ABLG were found after 6 months of diet. The presence of ABLG in the majority of untreated coeliac patients may reflect an increased permeability of the intestinal mucosa during the active stage of the disease.
Caiulo
V A
VA
Istituto di Clinica Pediatrica, Università di Pisa, Italia.
Cortigiani
L
L
Ughi
C
C
Ceccarelli
M
M
D000293:Adolescent; D000906:Antibodies / Q000097:blood*; D002446:Celiac Disease / Q000178:diet therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015200:Fluoroimmunoassay; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption / Q000276:immunology*; D007782:Lactoglobulins / Q000276:immunology*
D000906:Antibodies; D007782:Lactoglobulins
Gli anticorpi anti beta-lattoglobulina come indice di aumentata permeabilità intestinale in corso di malattia celiaca.