Y-chromosomal influences on renal and adrenal measures in mice.
From a four-way cross between unrelated inbred strains of mice, a random-breeding line was developed that segregated at two coat-color loci and carried Y chromosomes from different sources. Adult males were used for measurements of body weight, kidney weight, renal papilla length, and adrenal gland weight. Clear evidence was obtained of Y-linked influences on papilla length and adrenal weight, whereas direct effects of Autosome 9 were indicated with regard to adrenal weight only. Epistatic interaction of the Y chromosome with Autosome 4 was found for kidney weight and a 4-9 interaction appeared for papilla length. The direct effects of Y-chromosomal variation are interpreted in terms of a functional relationship between adrenal action and the development of Henle's loops and, in connection with previous findings, discussed in terms of adrenal functioning in the regulation of hippocampally-mediated behaviors.
Van Abeelen
J H
JH
Department of Animal Physiology, University of Nijmegen, The Netherlands.
Leenders
H J
HJ
Lemmens
W A
WA
D000311:Adrenal Glands / Q000033:anatomy & histology* / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D007668:Kidney / Q000033:anatomy & histology* / Q000502:physiology; D008138:Loop of Henle / Q000033:anatomy & histology / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000502:physiology; D014998:Y Chromosome