Sex chromosomes in a series of 79 colorectal cancers: replication pattern, numerical, and structural changes.
The cytogenetic study of a series of 79 colorectal cancers was performed with special attention to sex chromosome behavior. It was found that apart from other chromosomal changes, the early-replicating X chromosome (Xe) was frequently duplicated in tumors from both males and females. This contrasted with a frequent loss of either the late-replicating X (XI) in tumors from females or of the Y chromosome in tumors from males. All the detected unbalanced rearrangements resulted in a gain of the long, but not the short, arm of the X chromosome. The replication pattern of Xe chromosomes was similar to that of control tissues, whereas that of XI chromosomes was unusual. Its main characteristic was that the two major R bands of the short arm, Xp11 and Xp22, replicated too early.
Muleris
M
M
Department of Biology, Institut Curie, Paris, France.
Dutrillaux
A M
AM
Salmon
R J
RJ
Dutrillaux
B
B
D000782:Aneuploidy; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics*; D004261:DNA Replication; D005260:Female; D006801:Humans; D008297:Male; D012730:Sex Chromosomes / Q000648:ultrastructure; D014960:X Chromosome