[A case of mixed connective tissue disease exacerbated by griseofulvin complicating aseptic meningo-encephalitis and disseminated intravascular coagulation].
A variety of drugs have been implicated in causing or exacerbating SLE (drug-related lupus). Griseofulvin, the most commonly used agent in the treatment of fungal infections in the skin, has been shown to be a possible SLE-activating drug in several case reports. In the literature, however, any similar drug reactions have not been reported in MCTD, despite sharing features of SLE. The first case of drug (griseofulvin)-exacerbated MCTD was described and discussed. The patient was a 36-year-old woman with a six-year history of MCTD and subclinical Sjögren's syndrome. She developed aseptic meningo-encephalitis and disseminated intravascular coagulation after two weeks of continuous oral administration of griseofulvin 375 mg per day for trichophytosis of the feet. Following cessation of griseofulvin with anticoagulants, antibiotics, and high dose steroids at the same time, she greatly improved within one week.
Okazaki
H
H
Department of Medicine, Jichi Medical School, Tochigi.
Hatakeyama
M
M
Mori
M
M
Minato
N
N
Sumiya
M
M
Kano
S
S
D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced* / Q000150:complications; D005260:Female; D006118:Griseofulvin / Q000009:adverse effects*; D006801:Humans; D008590:Meningoencephalitis / Q000139:chemically induced* / Q000150:complications; D008947:Mixed Connective Tissue Disease / Q000150:complications*
D006118:Griseofulvin