title: The place of simultaneous pharmacokinetic pharmacodynamic modeling in new drug development: trends and perspectives.
abstract: The potential applications in drug development of pharmacokinetic-pharmacodynamic modeling are numerous: optimal medication regimen, design of galenic forms, identification of specific effects of metabolites and enantiomers. Nevertheless, this methodology is presently under-used, as appears from an analysis of the literature. We examine this point as well as progress in both non-invasive pharmacodynamic measurement and specific experimental design that could lead to a future extension of PK-PD in toxicology and phase I drug development.
authors.affiliation: Unité de Pharmacologie Clinique, Hôpital Neuro-Cardiologique, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Girard
authors.forename: P
authors.initials: P
authors.lastname: Nony
authors.forename: J P
authors.initials: JP
authors.lastname: Boissel
mesh_terms: D004341:Drug Evaluation; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology / Q000639:trends*