The acenocoumarol-carrageenin test.
Rats received a single subcutaneous dose of the inflammatory agent carrageenin on the top of the skull, followed by oral acenocoumarol for 3 days; in every case, an extensive haematoma was observed on the skull on day 4. The capillary resistance on the depilated dorsal skin was significantly reduced by this combined inflammatory + anticoagulant treatment. Haematoma development was not inhibited by cortisone, non-steroidal anti-phlogistics (piroxicam, proquazone) or benzopyrone derivatives (hesperidin methylchalcone, oligomeric procyanidin). On pretreatment with vitamin K1 for 1 day, followed by daily treatment for 3 days, no haematoma was observed.
Gábor
M
M
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Rázga
Z
Z
D000074:Acenocoumarol; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002196:Capillaries / Q000187:drug effects; D002351:Carrageenan; D002867:Chromones / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006406:Hematoma / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013256:Steroids; D014655:Vascular Resistance / Q000187:drug effects; D010837:Vitamin K 1 / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D003374:Coumarins; D013256:Steroids; D010837:Vitamin K 1; D002351:Carrageenan; D000074:Acenocoumarol