[Preparation of derivatives of the aldehydic functions of gossypol].
Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.
Kunesch
N
N
Laboratoire de Chimie des Substances thérapeutiques naturelles, UA CNRS n. 496, Centre d'Etudes pharmaceutiques, Châtenay-Malabry.
Barbier
M P
MP
Dalkafouki
A
A
Poisson
J E
JE
D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism; D012545:Schiff Bases / Q000138:chemical synthesis
D011073:Polyamines; D012545:Schiff Bases; D006072:Gossypol
Préparation de dérivés de la fonction aldéhyde du gossypol.