title: The role of corticosteroids in infants and children with bacterial meningitis.
abstract: Bacterial meningitis continues to be a cause of substantial morbidity in infants and children. Hearing impairment is the most common sequela of this disease. Corticosteroids have been used in an attempt to reduce the incidence of meningitis-induced hearing loss. Some studies have demonstrated a decrease in the incidence of hearing impairment in patients treated with cefuroxime plus dexamethasone compared with cefuroxime alone. Similar data are lacking for other frequently used antibiotics. Based on these studies, the use of dexamethasone should be considered in infants and children greater than two months of age with suspected bacterial meningitis. Critical issues including the timing of steroid initiation in relation to antibiotic therapy and the appropriate antibiotic-corticosteroid regimen must be addressed. Studies should be performed to define the exact role of corticosteroids in the treatment of bacterial meningitis. Until additional data are available, we recommend the use of dexamethasone in pediatric patients older than two months of age with bacterial meningitis.
authors.affiliation: College of Pharmacy, Ohio State University, Columbus.
authors.forename: N
authors.initials: N
authors.lastname: Bahal
authors.forename: M C
authors.initials: MC
authors.lastname: Nahata
mesh_terms: D002439:Cefotaxime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006313:Hearing Loss, Central / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D013997:Time Factors
chemical_list: D003907:Dexamethasone; D002439:Cefotaxime