Cefodizime, a new 2-aminothiazolyl cephalosporin: physicochemical properties, toxicology and structure-activity relationships.
Cefodizime is a 2-aminothiazolyl cephalosporin for parenteral use. Cefodizime has a bisubstituted thiothiazole moiety in position 3 of the cephem nucleus. The presence of this moiety does not alter the in-vitro antibacterial activity, or safety in animal studies, which are similar to those of cefotaxime, but results in an apparent long elimination half-life in rodents and dogs, and in novel immunological properties.
Bryskier
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A
Centre de recherche Roussel-Uclaf, Romainville, France.
Procyk
T
T
Labro
M T
MT
D000818:Animals; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D013329:Structure-Activity Relationship
D002439:Cefotaxime; C033356:cefodizime