title: Flavonoids inhibit the expression of heat shock proteins.
abstract: Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetin and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents.
authors.affiliation: Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hosokawa
authors.forename: K
authors.initials: K
authors.lastname: Hirayoshi
authors.forename: A
authors.initials: A
authors.lastname: Nakai
authors.forename: Y
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: N
authors.initials: N
authors.lastname: Marui
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: A
authors.initials: A
authors.lastname: Aoike
authors.forename: K
authors.initials: K
authors.lastname: Kawai
mesh_terms: D003110:Colonic Neoplasms / Q000473:pathology; D005419:Flavonoids / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D006358:Hot Temperature; D006801:Humans; D011794:Quercetin / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D005419:Flavonoids; D006360:Heat-Shock Proteins; D011794:Quercetin