Apparent lack of usefulness of monoclonal antibody Ki-67 in thyroid tumour pathology. Relation to histological typing and classification.
In order to test its potential application to thyroid tumour pathology, the monoclonal antibody Ki-67 was used to demonstrate immunohistochemically proliferating cells in 31 non neoplastic and neoplastic lesions of the thyroid. Twenty benign lesions were negative. Of the 11 malignant tumors, 4 papillary, 2 follicular and 1 medullary carcinomas were also negative; only 3 follicular and 1 medullary carcinomas were positive. Moreover, no correlation was found between Ki-67 immunostaining status and histological typing or pTNM pathological classification in the 11 malignant tumors.
Rigaud
C
C
Laboratoire d'Anatomie Pathologique, Institut Jean Godinot, Reims, France.
Bogomoletz
W V
WV
D000911:Antibodies, Monoclonal; D006801:Humans; D019394:Ki-67 Antigen; D009687:Nuclear Proteins / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009687:Nuclear Proteins