title: Effects of nifedipine on left ventricular diastolic dysfunction after myocardial infarction.
abstract: In order to assess the effects of nifedipine on left ventricular diastolic abnormalities, 26 patients (mean age 52 year, range 42-66) were studied 10 days after a first myocardial infarction, at rest and during handgrip by Doppler examination. The time-velocity integral for the rapid (E) and atrial (A) filling phases and the E/A ration were used; stroke volume was calculated as the aortic time-velocity integral times the cross-sectional valvular area. Twenty age-matched normal subjects constituted the controls. Twenty-one patients had a reversal of the early to late diastolic filling pattern; five patients had a restrictive pattern. Nifedipine normalized left ventricular filling in patients with a reverse pattern, both at rest and during handgrip. Moreover, these patients showed a descending left ventricular function curve by relating at rest and handgrip values of cardiac index and the E/A ratio. After nifedipine, these study patients showed an ascending left ventricular curve, similar to that of normal subjects, with an increase in cardiac index and a slight decrease in the E/R ratio. No beneficial effects were detectable in patients with a restrictive pattern of left ventricular filling.
authors.affiliation: Department of Cardiology, Medical School, University of Padua, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Scognamiglio
authors.forename: G
authors.initials: G
authors.lastname: Fasoli
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects; D015150:Echocardiography, Doppler; D005080:Exercise Test; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D009543:Nifedipine