title: Clinical and neuropsychological effects of desipramine in children with attention deficit hyperactivity disorder.
abstract: Desipramine is a tricyclic antidepressant with demonstrated efficacy for some children with attention deficit hyperactivity disorder (ADHD). In this controlled study, clinical improvement was noted in a group of 12 ADHD children. There also were neuropsychological effects associated with desipramine treatment: a small but significant decline in motor performance and an improvement in long-term verbal memory. The decline in motor performance may be of only limited clinical significance, but it is an effect that desipramine seems to share with other tricyclic antidepressants. The improvement in memory performance is an effect it shares with the psychostimulants.
authors.affiliation: North Carolina Neuropsychiatry, Chapel Hill 27516.
authors.forename: C T
authors.initials: CT
authors.lastname: Gualtieri
authors.forename: P A
authors.initials: PA
authors.lastname: Keenan
authors.forename: M
authors.initials: M
authors.lastname: Chandler
mesh_terms: D000339:Affect / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D001519:Behavior / Q000187:drug effects; D002648:Child; D003891:Desipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D003891:Desipramine