Monosomy 20: a nonrandom finding in childhood acute lymphoblastic leukemia.
We describe four cases of childhood acute lymphoblastic leukemia with monosomy 20 as the sole cytogenetic abnormality. These cases represent 3.4% of cytogenetically abnormal childhood ALL studied in our institute at diagnosis. The patients presented at similar age, ranging from 31 to 36 months. All four patients remain in first remission with survival time being at least 20 months from the time of diagnosis.
Betts
D R
DR
ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, England.
Kingston
J E
JE
Dorey
E L
EL
Young
B D
BD
Webb
D
D
Katz
F E
FE
Gibbons
B
B
D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002675:Child, Preschool; D002890:Chromosomes, Human, Pair 20; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D009006:Monosomy; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology
D015703:Antigens, CD; D006684:HLA-DR Antigens