title: Evaluation of salvage surgery in heavily irradiated cancer of the buccal mucosa.
abstract: This report describes the authors' experience with salvage surgery in 78 patients with carcinoma of the buccal mucosa who failed after high-dose radical radiation therapy at Regional Cancer Centre, Trivandrum, India. Forty-four patients (56%) required a hemimandibulectomy for adequate tumor clearance. Fifty-four patients (69%) required a primary reconstructive procedure for wound closure. Follow-up periods ranged from 28 months to 63 months (median follow-up, 41 months). Thirteen patients (17%) developed nonfatal postoperative complications. Thirty-one patients recurred after surgery, five of whom were again salvaged by further surgery. Overall, the recurrence rate was 36%. Most of the recurrences (26/31) were at the primary site. The overall 5-year actuarial disease-free survival after salvage surgery was 59.7%. T stage of the recurrent tumor and its skin infiltration emerged as factors which significantly influenced disease-free survival (P less than 0.05).
authors.affiliation: Regional Cancer Centre, Trivandrum, Kerala, India.
authors.forename: T
authors.initials: T
authors.lastname: Cherian
authors.forename: P
authors.initials: P
authors.lastname: Sebastian
authors.forename: M I
authors.initials: MI
authors.lastname: Ahamed
authors.forename: K L
authors.initials: KL
authors.lastname: Jayakumar
authors.forename: P
authors.initials: P
authors.lastname: Sivaramakrishnan
authors.forename: G
authors.initials: G
authors.lastname: Jeevy
authors.forename: R
authors.initials: R
authors.lastname: Sankaranarayanan
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011183:Postoperative Complications; D015996:Survival Rate