title: Physical map around the retinoblastoma gene: possible genomic imprinting suggested by NruI digestion.
abstract: A long-range restriction map constructed around the retinoblastoma (RB) gene by means of PFGE analysis allowed further definition of chromosomal rearrangements with a breakpoint within the gene, as well as of submicroscopic deletions. A serendipitous observation was that the NruI restriction pattern differs according to the parental origin of the rearrangement.
authors.affiliation: U. 173 INSERM, Hôpital Necker-Enfants-Malades, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Blanquet
authors.forename: C
authors.initials: C
authors.lastname: Turleau
authors.forename: J
authors.initials: J
authors.lastname: de Grouchy
authors.forename: N
authors.initials: N
authors.lastname: Creau-Goldberg
mesh_terms: D015139:Blotting, Southern; D002872:Chromosome Deletion; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D015183:Restriction Mapping; D012175:Retinoblastoma / Q000235:genetics*
chemical_list: D015342:DNA Probes; C055654:endodeoxyribonuclease NruI; D015252:Deoxyribonucleases, Type II Site-Specific