Acyclovir-induced acute tubulo-interstitial nephritis.
Two patients with presumed herpes simplex encephalitis developed severe non-oliguric acute renal failure shortly after acyclovir infusions. Renal function returned to normal in less than 3 weeks after discontinuation of acyclovir. Renal biopsies done during the acute phase demonstrated interstitial oedema, eosinophils and cellular aggregates in both and granulomata in the second case suggesting acyclovir-induced hypersensitivity interstitial nephritis.
Rashed
A
A
Department of Medicine, Hamad General Hospital, Doha, Qatar.
Azadeh
B
B
Abu Romeh
S H
SH
D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D004660:Encephalitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
D000212:Acyclovir