Effects of the prodrug nabumetone, and its active metabolite, 6-MNA, on human and rat gastric mucosal prostanoids and platelet function.
Jeremy
J Y
JY
Royal Free Hospital, London, United Kingdom.
Mikhailidis
D P
DP
Barradas
M A
MA
Kirk
R M
RM
Dandona
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D002074:Butanones / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis*; D011464:Epoprostenol / Q000096:biosynthesis*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D000077430:Nabumetone; D009280:Naphthaleneacetic Acids / Q000494:pharmacology*; D009288:Naproxen / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011355:Prodrugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D009280:Naphthaleneacetic Acids; D010975:Platelet Aggregation Inhibitors; D011355:Prodrugs; D009288:Naproxen; C044612:6-methoxy-2-naphthylacetic acid; D011464:Epoprostenol; D015232:Dinoprostone; D000077430:Nabumetone; D007213:Indomethacin