Cardiac acetylcholinesterase molecular forms and choline acetyltransferase in the Dahl (salt-sensitive) hypertensive strain of rats: a regional study.
A regional study of acetylcholinesterase (AChE) molecular forms and choline acetyltransferase (ChAT) in the hearts of Dahl-salt sensitive (DS) and salt resistant (DR) rats was performed in animals administered either 8% or 0.35% dietary NaCl. Atria isolated from DS rats, regardless of dietary NaCl intake, had lower activities of all of the AChE molecular forms and ChAT when compared to their dietary-matched DR controls. In the ventricles, the activities of AChE molecular forms and ChAT were lower in DS rats compared to dietary-matched DR rats only when 8% NaCl diets were administered. The percent contribution of each of the molecular forms to the total AChE pool was not affected by animal strain or diet.
Nyquist-Battie
C
C
School of Basic Life Sciences, University of Missouri-Kansas City 64108.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000201:enzymology; D006325:Heart Atria / Q000201:enzymology; D006352:Heart Ventricles / Q000201:enzymology / Q000473:pathology; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D014018:Tissue Distribution
D012965:Sodium Chloride; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase