[Thiophene as a structural element in physiologically active substances. 18. A thiophene analog of propafenone].
The preparation of compounds 1, which are thiophene analogues of propafenon (A) is described. Compound 1a shows antiarrhythmic activity in various in vivo test-systems.
Binder
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Institut für Organische Chemie, Technischen Universität, Wien.
Noe
C R
CR
Holzer
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W
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D051379:Mice; D011405:Propafenone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D013876:Thiophenes; D011405:Propafenone
Thiophen als Strukturelement physiologisch aktiver Substanzen, 18. Mitt.: Ein Thiophenanalogon des Propafenons.