Bioactivation of 2,6-di-tert-butyl-4-methyl phenol (BHT) and hydroxylated analogues to toxic quinoid metabolites.
Thompson
J A
JA
Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado, Boulder 80309-0297.
Bolton
J L
JL
Schullek
K M
KM
Sevestre
H
H
D000818:Animals; D001711:Biotransformation; D002084:Butylated Hydroxytoluene / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D011809:Quinones / Q000378:metabolism / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D011809:Quinones; D002084:Butylated Hydroxytoluene