[The effect of tuftsin on fibrin polymerization in vitro and on the hemostatic system when administered intravenously to healthy animals].
Taftsine tetrapeptide has antiprocoagulatory properties in vitro in the presence of plasma. Taftsine exerts depolymerization influence on fibrin monomer in concentrations of 10(-1) to 10(-9) mg/ml. At intravenous injection in doses of 1 mg and 300 ug/kg, taftsine causes the increase in plasma clotting time and significant increase in enzymatic and nonenzymatic fibrinolysis. The effect can be observed during 120 min after injection of the peptide.
Ashmarin
I P
IP
Pastorova
V E
VE
Liapina
L A
LA
Kudriashov
B A
BA
Kalikhevich
V N
VN
Kamenskiĭ
A A
AA
Azieva
L D
LD
D000818:Animals; D001704:Biopolymers; D004305:Dose-Response Relationship, Drug; D005338:Fibrin Fibrinogen Degradation Products / Q000187:drug effects* / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013997:Time Factors; D014405:Tuftsin / Q000008:administration & dosage / Q000494:pharmacology*
D001704:Biopolymers; D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; D014405:Tuftsin
Vliianie taftsina na polimerizatsiiu fibrina in vitro i sistemu gemostaza pri vnutrivennom vvedenii zdorovym zhivotnym.