[Opposite control of O2 affinity for hemoglobin by donors and acceptors].
The effects of electron donors and acceptors on O2 binding by hemoglobin were studied. 2,4-Dinitrophenol, levomycetin and pelargonidine-3,5-diglycoside which act as electron acceptors in free radical reactions, enhance this process. In contrast, N-propylajmalin which is known to be an electron donor in the above reactions, suppresses the O2 binding. Diphosphoglycerate and inositol hexaphosphate, the natural inhibitors of O2 binding, exhibit, similar to N-propylajamlin, the properties of electron donors, the latter being a more potent electron donor than the former.
Marinov
B S
BS
Ruzieva
R Kh
RKh
D019297:2,4-Dinitrophenol; D000872:Anthocyanins; D002701:Chloramphenicol / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D004163:Diphosphoglyceric Acids / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D010100:Oxygen / Q000097:blood*; D010833:Phytic Acid / Q000494:pharmacology; D011219:Prajmaline / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D014475:Uncoupling Agents / Q000494:pharmacology
D000872:Anthocyanins; D004140:Dinitrophenols; D004163:Diphosphoglyceric Acids; D005419:Flavonoids; D006027:Glycosides; D006454:Hemoglobins; D014475:Uncoupling Agents; D002701:Chloramphenicol; D011219:Prajmaline; C066957:pelargonidin; D010833:Phytic Acid; D019297:2,4-Dinitrophenol; D010100:Oxygen
Protivopolozhno napravlennaia donorami i aktseptorami reguliatsiia srodstva kisloroda k hemoglobinu.