[Protective effect of diallyl sulfide, a natural extract of garlic, on MNNG-induced damage of rat glandular stomach mucosa].
In order to predict the chemopreventive activity of garlic on gastric cancer, the effect of diallyl sulfide (DAS), a natural extract of the garlic, on MNNG-induced nuclear aberration (NA) and ornithine decarboxylase (ODC) activity in Wistar rat glandular stomach mucosa was studied. The results showed that NA and ODC activity were positively correlated to MNNG dose given 24 and 6 hr after oral intubation with MNNG. Oral or parenteral pretreatment with DAS significantly and dose-dependently inhibited MNNG-induced NA and ODC. These data suggest that DAS has the potential to inhibit MNNG-induced gastric cancer, supporting the epidemiological evidence of the chemopreventive effect of garlic on gastric cancer.
Hu
P J
PJ
First Hospital, Zhongshan Medical College, Guangzhou.
D000498:Allyl Compounds; D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005737:Garlic; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008769:Methylnitronitrosoguanidine; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013440:Sulfides / Q000494:pharmacology*
D000498:Allyl Compounds; D013440:Sulfides; D008769:Methylnitronitrosoguanidine; C038491:allyl sulfide; D009955:Ornithine Decarboxylase