Identification of a decapeptide region of human interferon-alpha with antiproliferative activity and homology to an immunosuppressive sequence of the retroviral transmembrane protein P15E.
We have identified a 10-amino acid sequence (amino acid, 9-18) from interferon-alpha (IFN-alpha) that when presented as a synthetic peptide inhibits both the proliferation of the Daudi lymphoblastoid cell line and the antigen receptor-stimulated proliferation of fresh human T lymphocytes. This sequence, which was identified by virtue of its sequence similarity (70% identity) to the immunosuppressive sequence of the retroviral transmembrane protein p15E, represents the smallest fragment of IFN-alpha that has been shown to date to be biologically active.
Ruegg
C L
CL
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Strand
M
M
D000595:Amino Acid Sequence; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry; D007370:Interferon Type I / Q000737:chemistry* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology; D012191:Retroviridae Proteins / Q000737:chemistry / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid
D007166:Immunosuppressive Agents; D007370:Interferon Type I; D008565:Membrane Proteins; D010446:Peptide Fragments; D012191:Retroviridae Proteins