Increased thromboxane production after whole body irradiation.
Irradiation causes an increase in serum and plasma level of thromboxane in rabbits and an increase in thromboxane synthesis in blood platelets stimulated by thrombin. Thromboxane release from thoracic aorta is also increased upon irradiation of animals. H2O2 which stimulates thromboxane release from thoracic control aorta is without effect in the irradiated one.
Sochanowicz
B
B
Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warszawa, Poland.
Przygoda
E
E
Dancewicz
A M
AM
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D001792:Blood Platelets / Q000378:metabolism / Q000528:radiation effects*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000528:radiation effects; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000097:blood / Q000528:radiation effects; D014916:Whole-Body Irradiation
D013929:Thromboxane B2; D013928:Thromboxane A2; D006861:Hydrogen Peroxide