[Spectral analysis and color-coded Doppler study of the changes in aortic regurgitation induced by vasodilators in asymptomatic patients with severe aortic insufficiency].
The acute effects of 20 mg of sublingual nifedipine in 12 patients with chronic severe aortic regurgitation were evaluated with M-mode echocardiography, continuous wave and colour Doppler. After nifedipine, heart rate increased from 68 +/- 8 to 82 +/- 11 beats/m' (p less than 0.001); arterial systolic and diastolic pressures decreased from 143 +/- 16 to 129 +/- 9 mmHg (p less than 0.01) and from 61 +/- 11 to 53 +/- 17 mmHg (p less than 0.01) respectively. Left ventricular systolic and diastolic diameters also decreased from 50 +/- 4 to 46 +/- 4 mm (p less than 0.01) and 76 +/- 6 to 72 +/- 6 mm (p less than 0.01) respectively; the slightly increase in fractional shortening which occurred was not significant. The aortic systolic and diastolic velocity integrals decreased from 38 +/- 9 to 34.7 +/- 8 cm (p less than 0.01) and from 203 +/- 41 to 163 +/- 29 cm (p less than 0.001); the diastolic slope of the velocity curve increased a little but significantly: from 334 +/- 70 to 394 +/- 70 cm/sec2 (p less than 0.01). With colour Doppler, protodiastolic jet areas decreased by 19% in the long parasternal view (p less than 0.01), by 28% in the apical view (p less than 0.001), by 26% in the short-axis view (p less than 0.01); the length of the jets in the long parasternal view decreased by 14% (p less than 0.001), but the height did not change significantly. Positive changes from acute nifedipine administration are present in this study.(ABSTRACT TRUNCATED AT 250 WORDS)
Montemurro
D
D
Servizio di Cardiologia, Ospedale CTO, Torino.
Ronzani
G
G
Gozzelino
G
G
Spadaccini
L
L
Panataro
C
C
Brusca
A
A
D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*
D009543:Nifedipine
Studio Doppler ad analisi spettrale e a codice di colori delle modificazioni del rigurgito aortico indotte da vasodilatatori in pazienti asintomatici affetti da insufficienza aortica grave.