[Effect of 3 months of thioacetamide treatment on liver biotransformation in vivo and in vitro (various times after discontinuation)].
Female Uje: WIST rats received thioacetamide (TAA) in the tap water (0.3 g/l) from the 4th to 6th months of life to produce experimental liver cirrhosis. Immediately, 2 and 7 days after TAA cessation it was investigated by means of in vivo (caffeine and metamizol elimination) and vitro methods (cytochrome P-450, 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylation), whether this animal model represents the restricted cytochrome P-450-dependent biotransformation comparable to human liver cirrhosis. The total capacity of the liver was diminished immediately and 2 days after TAA cessation. After 7 days the capacity was unchanged compared to the controls or partly even enhanced. Therefore, this animal model reflects rather a short time than a stable alteration of biotransformation after TAA cessation comparable to human liver cirrhosis.
Lattermann
K
K
Institut für Klinische Pharmakologie, Friedrich-Schiller-Universität Jena.
Kraul
H
H
Hoffmann
A
A
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D002110:Caffeine / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004177:Dipyrone / Q000493:pharmacokinetics; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008115:Liver Regeneration / Q000187:drug effects*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013853:Thioacetamide / Q000633:toxicity*
D013853:Thioacetamide; D002110:Caffeine; D004177:Dipyrone; D003577:Cytochrome P-450 Enzyme System
Der Einfluss einer dreimonatigen Thioazetamidbehandlung auf die Biotransformation der Leber in vivo und in vitro (unterschiedliche Karenzzeiten).