title: Amino acids and peptides. XIII. Synthetic studies on N-terminal tripeptide amide analogs of fibrin alpha-chain.
abstract: N-Terminal tripeptide analogs of fibrin alpha-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Hirase
authors.forename: M
authors.initials: M
authors.lastname: Miyano
authors.forename: Y
authors.initials: Y
authors.lastname: Imoto
authors.forename: M
authors.initials: M
authors.lastname: Iwamoto
mesh_terms: D000595:Amino Acid Sequence; D005337:Fibrin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D010455:Peptides; D005337:Fibrin