[Interrelationship between the thiamine content, thiamine diphosphate-dependent enzyme activity and reduced glutathione level in the rat liver].
Changes in the amount of thiamine, reduced glutathione, thiamine diphosphate-dependent dehydrogenase activity has been traced after thiamine injection to thiamine-deficient rats and oxythiamine to normal rats. The obtained data show that a drop in reduced glutathione level was a primary reason of the alpha-keto-acid dehydrogenase activity reduction under conditions of the thiamine deficiency. The existence of immediate connection between thiamine and glutathione metabolism is supposed.
Parkhomenko
Iu M
IuM
Chernysh
I Iu
IIu
Protasova
Z S
ZS
Donchenko
G V
GV
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013831:Thiamine / Q000378:metabolism*; D014174:Transketolase / Q000378:metabolism
D011768:Pyruvate Dehydrogenase Complex; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase; D005978:Glutathione; D013831:Thiamine
Issledovanie vzaimosviazi mezhdu soderzheniem tiamina, aktivnost'iu tiamindifosfatzavisimykh fermentov i urovnem vosstanovlennogo glutationa v pecheni krys.