title: The effect of domperidone on the electrical response of cockroach salivary gland acinar cells.
abstract: The effects of domperidone on the electrical response of the cockroach salivary gland to applied dopamine and to nerve stimulation have been investigated. Dopamine and nerve stimulation induced a hyperpolarization of the salivary gland acinar cells, which was occasionally followed by a depolarization. At 1 and 10 microM domperidone had no effect on the responses; however, at higher concentrations domperidone (50 and 100 microM) potentiated the hyperpolarization induced by both dopamine and nerve stimulation. Domperidone (50 microM) also potentiated the hyperpolarization induced by 5-HT. Thus the potentiation probably results from a post synaptic action independent of either the dopamine or 5-hydroxytryptamine receptor. In addition, domperidone (50 and 100 microM) had two delayed effects; one, presynaptic, led to a reduction in the response to nerve stimulation; the other, postsynaptic, led to the abolition of the depolarizing phase of the response.
authors.affiliation: Department of Pharmacology, University of Edinburgh, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Evans
authors.forename: K L
authors.initials: KL
authors.lastname: Green
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003058:Cockroaches / Q000502:physiology*; D004294:Domperidone / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D012469:Salivary Glands / Q000166:cytology / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology
chemical_list: D012701:Serotonin; D004294:Domperidone; D004298:Dopamine