Enhancement by dietary iron of lipid peroxidation in mouse colon.
Feeding mice diets containing different amounts of Fe-fumarate over a period of 4 weeks resulted in a dose-dependent increase of iron concentrations in liver as well as proximal and distal colon. In parallel, a dose-dependent increase in lipid peroxidation was observed in these organs; both effects were well correlated. No significant effects were seen in other organs (lung, heart, brain or kidney). As dietary iron was shown to enhance dimethylhydrazine-induced colon carcinogenesis in mice, it is concluded that oxygen activation and lipid peroxidation might be involved in colon tumorigenesis and cell proliferation.
Younes
M
M
Institute of Toxicology, Medical Unversity of Lübeck, FRG.
Trepkau
H D
HD
Siegers
C P
CP
D000818:Animals; D003106:Colon / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005296:Ferrous Compounds / Q000378:metabolism*; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice
D005296:Ferrous Compounds; D007501:Iron; C031621:ferrous fumarate