title: [Analgesic and antipyretic effects of cyproheptadine].
abstract: Cyproheptadine-HCl raised the pain thresholds during hot plat test and writhing test in mice and tail flick test in rats, strengthened the hypnotic action by subthreshold dosage of sodium pentobarbital and chloral hydrate. The ED50 were 4.4 (3.2-5.7) and 12.4 (8.4-18.2) mg/kg 30 min after ip cyproheptadine in mice and rats, respectively. The ED50 was 0.14 (0.12-0.18) mg/kg 90 min after icv cyproheptadine in mice. Cyproheptadine po 20, 40 mg/kg and ip 10, 20 mg/kg showed significant antipyretic effects on yeast-induced pyrexia in rats.
authors.affiliation: Department of Pharmacology, Second Military Medical College, Shanghai, China.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Tan
authors.forename: C K
authors.initials: CK
authors.lastname: Fan
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: B
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003533:Cyproheptadine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000188:drug therapy; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006993:Hypnotics and Sedatives; D003533:Cyproheptadine