title: [Pros and cons of chemical litholysis in bile duct calculi].
abstract: Chemical litholysis of biliary stones is currently performed using monooctanoin (Mo) and methyl tert-butyl ether (MTBE). These two solvents dissolve cholesterol gallstones at different speeds due to their viscosity, high for Mo (47 cps) and low for MTBE (0.2 cps). A third compound was recently used which was produced by combining the previous two agents, Mo and MTBE, at a ratio of 2:1 v/v. The mixture has an intermediate viscosity (2.8 cps) and has shown good tolerability, management and efficacy with a 90% success rate in the treatment of post-surgical gallstones in 28 patients.
authors.affiliation: Clinica Chirurgica, Università degli Studi di Milano.
authors.forename: C
authors.initials: C
authors.lastname: Pozzi
authors.forename: R
authors.initials: R
authors.lastname: Tritapepe
mesh_terms: D000328:Adult; D000368:Aged; D001649:Bile Duct Diseases / Q000188:drug therapy; D002210:Caprylates; D002769:Cholelithiasis / Q000188:drug therapy*; D004338:Drug Combinations; D004341:Drug Evaluation; D004987:Ethers / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005989:Glycerides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D012997:Solvents / Q000627:therapeutic use*
chemical_list: D002210:Caprylates; D004338:Drug Combinations; D004987:Ethers; D005989:Glycerides; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether; C025343:monooctanoin
vernacular_title: I pro e i contro della litolisi chimica per i calcoli dei dotti biliari.