title: [Biological behavior of untreated bladder carcinoma in situ].
abstract: The biological behaviour of initially untreated carcinoma in situ of the bladder was studied in 20 patients. A 35.4-month follow-up revealed a heterogeneous behaviour of this disease entity. Diffuse tumors were clearly distinct from focal tumors. The evolution of the former appeared to be more aggressive: no spontaneous remission was observed, 58.3% remained as such while 41.6% progressed to muscle layer infiltration. Focal tumors evolved more favourably: only 1 (12.5%) developed into diffuse carcinoma in situ, 2 (25%) continued to be positive for cytology, while 4 (50%) remitted spontaneously. We therefore consider that both patient groups must be treated upon diagnosis. Intravesical treatment, which achieves a high rate of complete response, is advocated.
authors.affiliation: Servicio de Anatomía Patológica, Instituto Valenciano de Oncología (IVO), Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: Solsona
authors.forename: I
authors.initials: I
authors.lastname: Iborra
authors.forename: J V
authors.initials: JV
authors.lastname: Ricos
authors.forename: J L
authors.initials: JL
authors.lastname: Monrós
authors.forename: R
authors.initials: R
authors.lastname: Dumont
authors.forename: F
authors.initials: F
authors.lastname: Mazcuñán
authors.forename: J
authors.initials: J
authors.lastname: Casanova
authors.forename: C
authors.initials: C
authors.lastname: Calabuig
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D012075:Remission, Spontaneous; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
vernacular_title: Comportamiento biológico del carcinoma in situ vesical no tratado.