Systolic time intervals as indicators for cardiac function in rat models for heart failure.
Measurement of the pre-ejection period (PEP) can give valuable information on myocardial function in rats. Depressed cardiac function is accompanied by prolongation of PEP, which shortens when cardiac function improves. Left ventricular ejection time (LVET) may be shortened with ageing in spontaneously hypertensive rats.
Schoemaker
R G
RG
Department of Pharmacology, University of Limburg, Maastricht, The Netherlands.
Smits
J F
JF
D000367:Age Factors; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000627:therapeutic use; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology*; D002316:Cardiotonic Agents; D004280:Dobutamine / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D020105:Milrinone; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D011728:Pyridones / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D013599:Systole / Q000187:drug effects / Q000502:physiology*
D002316:Cardiotonic Agents; D011728:Pyridones; D004280:Dobutamine; D002216:Captopril; D020105:Milrinone