Evaluation of the cytotoxicity of some Mannich bases of acetophenone against the EMT6 tumour.
1-Phenyl-3-(4-morpholinyl)propan-1-one hydrochloride 1 and the related piperidino derivative 2 were shown to have activity against the EMT6 tumour in vitro. Modification of the structures of these compounds by introducing a glucosyloxy group onto the aryl rings lowered cytotoxicity but conversion of 1 and 2 into the corresponding bis-Mannich bases increased bioactivity considerably.
Dimmock
J R
JR
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Erciyas
E
E
Raghavan
S K
SK
Kirkpatrick
D L
DL
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents; D008352:Mannich Bases / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000098:Acetophenones; D000970:Antineoplastic Agents; D008352:Mannich Bases