[Effects of blast wave on methionine-enkephalin-like substance (MES) in guinea pig cochleas].
Methionine-enkephalin-like substance in the Corti's organs of guinea pigs with blast trauma-induced deafness was found to be lowered. The most serious changes occurred in the second turn 7 days after the exposure, MEE was then obviously elevated and almost totally recovered at the 23rd day. The transient changes of MEE suggest a reversible decrease of methionine-enkephalin (ME) which might be a neural transmitter within the olivocochlear bundle. The decrease of ME would possibly injure the resistance of hearing organ to further acoustic stimulation.
Liu
W
W
Xijing Hospital, Fourth Military Medical University, Xian.
D000818:Animals; D001753:Blast Injuries / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D005107:Explosions; D005260:Female; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000378:metabolism*; D008297:Male; D009925:Organ of Corti / Q000293:injuries / Q000378:metabolism*
C024693:enkephalin-Met, like substances; D004744:Enkephalin, Methionine