title: A novel skeletal drug delivery system for anti-bacterial drugs using self-setting hydroxyapatite cement.
abstract: To solve the problem of delivering drugs to skeletal tissue at high enough local concentrations for desirable therapeutic effects, we report a novel approach using a self-setting hydroxyapatite cement, with cephalexin and norfloxacin as model drugs. After setting, the cement was transformed into hydroxyapatite with affinity for hard bone tissue. Continuous in-vitro drug release profiles from loaded cement pellets (0.9-4.8% by weight) in phosphate buffer at pH 7.4 and 37 degrees C followed the Higuchi equation.
authors.affiliation: Kobe Women's College of Pharmacy, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Otsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: D
authors.initials: D
authors.lastname: Yu
authors.forename: J
authors.initials: J
authors.lastname: Wong
authors.forename: J L
authors.initials: JL
authors.lastname: Fox
authors.forename: W I
authors.initials: WI
authors.lastname: Higuchi
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D005079:Excipients; D006882:Hydroxyapatites / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D005079:Excipients; D006882:Hydroxyapatites