Inhibition of amphotericin B (Fungizone) toxicity to cells by egg lecithin-glycocholic acid mixed micelles.
Mixed micelles prepared from egg lecithin and the sodium salt of glycocholic acid markedly inhibited amphotericin B toxicity to mammalian cells without significantly affecting the antifungal effects of the drug.
Brajtburg
J
J
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Elberg
S
S
Kobayashi
G S
GS
Medoff
G
G
D000666:Amphotericin B / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004530:Egg Yolk / Q000032:analysis; D004912:Erythrocytes / Q000187:drug effects*; D006000:Glycocholic Acid / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008823:Micelles; D010713:Phosphatidylcholines / Q000494:pharmacology*
D008823:Micelles; D010713:Phosphatidylcholines; D000666:Amphotericin B; D006000:Glycocholic Acid