Retention of perfluorochemicals in tumor-bearing rats.
In order to study the elimination rate of perfluorochemical (PFC) emulsion from the blood and the PFC contents in the main organs of the tumor-bearing animals, Wistar strain rats were intramuscularly implanted with Walker 256 carcinosarcoma and 9L glioma cells were innoculated into the femoral muscle of Fischer rats. After 7 d the Wistar rats received an injection of 4 g PEC/kg of a PFC emulsion. The Fischer rats received a similar injection after 11 d. The rats injected with the PFC emulsion were periodically sacrificed for a week. There was no significant difference in PFC contents in the blood and main organs between normal rats and the tumor-bearing rats with either Walker 256 carcinosarcoma or 9L glioma. The PFC contents in Walker tumor were about 10 times as much as those of 9L tumor. The innoculated tumors did not substantially affect the PFC retention in the blood and the accumulation of PFC in main organs after intravenously injected with the PFC emulsion.
Tsuda
Y
Y
Green Cross Corporation, Osaka, Japan.
Murashima
R
R
Yamanouchi
K
K
Ueda
Y
Y
Yokoyama
K
K
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D005466:Fluorocarbons / Q000097:blood / Q000493:pharmacokinetics*; D005910:Glioma / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005466:Fluorocarbons