[Studies on chemical protectors against radiation. XXXII. Protective effects of methanol extracts of various Taiwan crude drugs on radiation injuries].
This study is to investigate radioprotective effects of 23 Taiwan crude drugs on X-ray induced bone marrow death and skin injury in mice. Each methanol extract of these Taiwan crude drugs was injected intraperitoneally into ICR male mice at 6 weeks of age before irradiation. Mice were whole-body irradiated with a soft X-ray generator. Radiation factors of the two screening tests used were as follows: 70 kVp, 10 mA, 10 mm acrylate filter, 70R/min, 2100R for survival test, and 30 kVp, 10 mA, 190R/min, 1100R for protective test on skin injury. As a result of these studies, the survival effect was recognized in Solani Incani Herba and Orthosiphi Aristati Herba. On the other hand, Mimosae Herba, Canarii Radix, Bombacis Radix, Arecae Fructus, Hedyotidis Diffusae Herba and Cynomorii Caulis were shown to have significant protective potency on skin injury.
Wang
C M
CM
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Ohta
S
S
Shinoda
M
M
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D000432:Methanol; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000528:radiation effects*; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
D004365:Drugs, Chinese Herbal; D000432:Methanol