[Severe anaphylactoid reactions after intravenous corticosteroids. Report of a case and review of the literature].
We report a case of fatal anaphylactic reaction to intravenous methylprednisolone succinate therapy developed in a 51 year old asthmatic man with aspirin intolerance and undetermined myocarditis. 14 similar cases were found in literature and analysed: asthma and aspirin intolerance seem to be risk factors; the organism reacts against either unconjugated corticoid or esterified corticoid principally its succinate salt; the mechanism of these reactions remains not clear; it may be either a true allergic reaction or a non specific reaction.
Laine-Cessac
P
P
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers.
Moshinaly
H
H
Gouello
J P
JP
Geslin
P
P
Allain
P
P
D000707:Anaphylaxis / Q000139:chemically induced*; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000150:complications; D004342:Drug Hypersensitivity / Q000150:complications; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged
D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate; D001241:Aspirin
Réactions anaphylactoïdes graves après corticoïdes intraveineux. A propos d'un cas et revue de la littérature.