title: Effect of the progestogen, allylestriol, on the bursal development of the chicken.
abstract: Fertile eggs were dipped on the fifth day of incubation into varying concentrations of allylestriol (AE), a synthetic progesterone, and testosterone propionate (TP). Concentrations of AE higher than 0.1% inhibited hatchability. The AE inhibited the differentiation of the bursal mesenchyme and follicular development and subsequently resulted in bursectomy. The AE caused bursectomy in 40-50 times lower concentrations than did TP. An unusual lymphocyte accumulation occurred around the postcapillary venules in the bursal mesenchyme of AE-treated birds. This observation suggested that inhibition of mesenchyme differentiation may lead to a modification in bursal function. The AE modification of bursal development was compared to those produced by TP. We demonstrated that AE caused immunosuppression of the B-cell system.
authors.affiliation: Semmelweis University Medical School, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Soos
authors.forename: I
authors.initials: I
authors.lastname: Olah
authors.forename: Z
authors.initials: Z
authors.lastname: Kittner
authors.forename: I
authors.initials: I
authors.lastname: Toro
authors.forename: B
authors.initials: B
authors.lastname: Glick
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D002060:Bursa of Fabricius / Q000187:drug effects* / Q000196:embryology / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D011374:Progesterone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C068349:allylestriol; D011374:Progesterone