title: A re-evaluation of the HSA-piroxicam interaction.
abstract: Piroxicam binding to HSA was studied using equilibrium dialysis and fluorescence methods. It was shown that this drug, like its analogs isoxicam and tenoxicam, binds to the apazone locus (site I area) and to a lesser extent to the diazepam site (site II). The piroxicam binding to HSA can be modulated by various specific ligands--apazone, warfarin, diazepam, ibuprofen--and these drug interactions have to be considered not only as potential displacement from the HSA binding sites but also in terms of induced allosteric effects.
authors.affiliation: Service Hospitalo-Universitaire de Pharmacologie, Faculté de Médecine, Creteil, France.
authors.forename: F
authors.initials: F
authors.lastname: Brée
authors.forename: S
authors.initials: S
authors.lastname: Urien
authors.forename: P
authors.initials: P
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Riant
authors.forename: E
authors.initials: E
authors.lastname: Albengres
authors.forename: J P
authors.initials: JP
authors.lastname: Tillement
mesh_terms: D001032:Apazone / Q000378:metabolism; D001665:Binding Sites; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D010894:Piroxicam / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D010894:Piroxicam; D001032:Apazone; D003975:Diazepam; D007052:Ibuprofen