title: Secondary acute lymphoblastic leukaemia with 4:11 translocation following treatment for Hodgkin's disease: case report and review of the literature.
abstract: It is apparent that treatment of Hodgkin's disease can be complicated by the development of secondary leukaemia. Most such leukaemias are of the non-lymphocytic type. We describe here a patient treated for Hodgkin's disease with chemo- and radiotherapy who developed secondary acute lymphoblastic leukaemia with a non-random chromosomal abnormality t(4;11). The frequency of such cases is assessed by a literature review and evidence for their pluripotent cell origin is discussed.
authors.affiliation: University Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: A
authors.initials: A
authors.lastname: Lennard
authors.forename: G H
authors.initials: GH
authors.lastname: Jackson
authors.forename: P J
authors.initials: PJ
authors.lastname: Carey
authors.forename: N
authors.initials: N
authors.lastname: Bown
authors.forename: P
authors.initials: P
authors.lastname: Middleton
authors.forename: S J
authors.initials: SJ
authors.lastname: Proctor
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology* / Q000235:genetics; D014178:Translocation, Genetic