Influence of testosterone isobutyrate on serum lipoproteins during replacement therapy of hypogonadal men.
Replacement therapy of hypogonadal men with testosterone isobutyrate, 100 mg by the i.m. route every two weeks, does not lead to a permanent significant change of the lipoprotein spectrum and to an increased risk of stereogenesis. The expected changes in the liver lipase activity and in the lipoprotein spectrum under the influence of the administered androgens are obviously suppressed by the antagonistic action of estrogens formed by conversion from androgens.
Hána
V
V
Third Medical Clinic, First Medical Faculty, Charles University Prague.
Marek
J
J
Ceska
R
R
Sobra
J
J
Hampl
R
R
Stárka
L
L
D000328:Adult; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D008074:Lipoproteins; D013739:Testosterone; C028499:testosterone isobutyrate