title: Differentiation of lesions caused by mycotoxin T-2 from autolytic morphologic change in CD-1 mice.
abstract: Experiments with topically applied T-2 trichothecene mycotoxin were undertaken to determine whether lesions caused by this toxin could be differentiated from autolysis. Two pathologists, who had previously seen lesions caused by T-2 toxin, graded lesions without knowledge of treatment group and stated whether the animal had received the toxin or not. Both pathologists differentiated T-2 toxin-treated mice up to 6 h post-mortem. Failure to distinguish between treated and control mice resulted in false-negative diagnoses only. It was concluded that the diagnosis of trichothecene mycotoxicosis would probably be missed more than 6 h post-mortem.
authors.affiliation: Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: C G
authors.initials: CG
authors.lastname: Rousseaux
authors.forename: H B
authors.initials: HB
authors.lastname: Schiefer
authors.forename: D S
authors.initials: DS
authors.lastname: Hancock
authors.forename: E D
authors.initials: ED
authors.lastname: Olfert
mesh_terms: D000818:Animals; D001329:Autolysis / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D015651:Mycotoxicosis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D009336:Necrosis / Q000175:diagnosis / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013605:T-2 Toxin / Q000009:adverse effects*; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
chemical_list: D013605:T-2 Toxin