[Monoclonal antibodies BCA-09 against blast cell surface antigen in acute myelomonoblastic leukemia].
Data are presented on the study of BCA-09 monoclonal antibodies (MCA) produced by 2G3 hybrid cells (a new strain). The conventional method of somatic hybridization of mouse myeloma cells and splenocytes of mice immunized with peripheral blood leucocytes from a patient with acute myelomonoblastic leukemia (AMML) was used to obtain hybridomas. The study of BCA-09 MCA specificity has shown that in more than half of cases they reveal surface membrane antigen of leukemia cells in patients with AMML, and do not react with blast cells of patients with other variants of leukemia and lymphosarcoma, as well as with blood cells of normal subjects, and with some human cultural cell lines. BCA-09 MCA can be recommended for the differential diagnosis of AMML and other forms of lymphoblastoses.
Novikova
N N
NN
Miterev
G Iu
GIu
Novikova
M S
MS
Bulycheva
T I
TI
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001752:Blast Crisis / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D006825:Hybridomas / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D007962:Leukocytes / Q000276:immunology* / Q000648:ultrastructure; D051379:Mice; D009101:Multiple Myeloma / Q000473:pathology; D009374:Neoplasms, Experimental / Q000473:pathology; D013154:Spleen / Q000473:pathology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface
Monoklonal'nye antitela BCA-09, napravlennye k poverkhnostnomu antigenu blastnykh kletok pri ostrom mielomonoblastnom leĭkoze.