Random drug excess.
If a patient is treated in a hospital, drugs are administered at 'deterministic', known times. However, if the patient is not supervised the times of drug intake may be less 'deterministic' and less well known. It seems therefore worthwhile to make a theoretical experiment in which one assumes that drugs are applied according to a random process. In the present article it is proposed that shot noise models could be used to represent concentration curves in such situations. By means of Monte Carlo methods different measures of random drug excess are described. An included program may encourage readers to consider these methods and to perform computer experiments.
Helfenstein
U
U
Biostatistisches Zentrum der Medizinischen Fakultät, Universität Zürich, Switzerland.
Steiner
M
M
D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D004364:Pharmaceutical Preparations