title: Calculation of kinetic parameters of a reversible enzymatic reaction in states of maximal activity.
abstract: Optimal values of the rate constants of a reversible enzymatic reaction are calculated by maximizing the enzymatic activity. The results depend on the substrate and product concentrations. Expressions for optimal maximal activities are derived and conclusions are drawn for the optimal ratios of substrate concentrations and Michaelis-constants.
authors.affiliation: Sektion Biologie, Bereich Biophysik, Humboldt-Universität Berlin, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Heinrich
authors.forename: E
authors.initials: E
authors.lastname: Hoffmann
authors.forename: H G
authors.initials: HG
authors.lastname: Holzhütter
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D010599:Pharmacokinetics; D013379:Substrate Specificity
chemical_list: D004798:Enzymes