title: The Helsinki Heart Study: central findings and clinical implications.
abstract: This paper describes the central findings and discusses the clinical implications of the Helsinki Heart Study. This was a controlled primary prevention trial to test the hypothesis that using gemfibrozil to lower the concentrations of serum low density lipoprotein (LDL) and very low density lipoprotein (VLDL) and to raise that of high density lipoprotein (HDL) protects subjects against coronary heart disease.
authors.affiliation: First Department of Medicine, University of Helsinki, Finland.
authors.forename: J K
authors.initials: JK
authors.lastname: Huttunen
authors.forename: V
authors.initials: V
authors.lastname: Manninen
authors.forename: M
authors.initials: M
authors.lastname: Mänttäri
authors.forename: P
authors.initials: P
authors.lastname: Koskinen
authors.forename: M
authors.initials: M
authors.lastname: Romo
authors.forename: L
authors.initials: L
authors.lastname: Tenkanen
authors.forename: O P
authors.initials: OP
authors.lastname: Heinonen
authors.forename: M H
authors.initials: MH
authors.lastname: Frick
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D004311:Double-Blind Method; D015248:Gemfibrozil / Q000627:therapeutic use*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008074:Lipoproteins; D015248:Gemfibrozil