[Neurophysiological study of propofol (2-6 diisopropylphenol): experimental data].
Propofol was assessed in laboratory animals using an experimental technique which leads to an over all appreciation of central nervous system function. After Bimar and Naquet, (1966) a battery of neurophysiological tests in the cat investigate specific primary pathways (visual evoked potentials), non specific pathways (arousal reaction) and hemodynamic response to painful aggression (stimulation of dentine). Propofol appears to be a powerful narco-hypnotic drug. More, it have an original property which is quite rapidly effective and unconnected with narcosis: a protective hemodynamic ("sympathoplegic or neuroleptic") effect. So, propofol, a new anesthetic agent, seems to be a progress with regard to other drugs used previously.
Emperaire-Le Pouleuf
N
N
Département d'anesthésie-réanimation, Hôpital de la Conception, Marseille.
Planche
D
D
Ottomani
A
A
Vuillon-Cacciuttolo
G
G
Dejode
J M
JM
Delmoral
B
B
Manelli
J C
JC
Bimar
J
J
D000771:Anesthesia, Intravenous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002415:Cats; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology*
D015742:Propofol
Etude neurophysiologique du propofol (2-6 diisopropylphenol): données expérimentales.