title: A comparative double-blind randomised study of single dose fosfomycin trometamol with trimethoprim in the treatment of urinary tract infections in general practice.
abstract: A double-blind, double-dummy trial comparing a single dose treatment with fosfomycin trometamol (FT, 3 g) versus trimethoprim (TMP, 200 mg) was carried out in women with uncomplicated urinary tract infections. From 51 clinically evaluable patients, 44 were bacteriologically assessable at the 6-week follow-up. The results were as follows in the FT group (n = 22): eradication in 17 (77.3%); recurrence in 2 (9%); reinfection in 2 (9%), and persistence in 1 (4.5%). For the TMP group (n = 22) the results were: eradication in 12 (54.5%); recurrence in 1 (4.5%); reinfection in 1 (4.5%), and persistence in 8 (33.3%). There were no significant adverse events reported with either agent.
authors.affiliation: Department of General Practice, University of Wales College of Medicine, Cardiff, UK.
authors.forename: R
authors.initials: R
authors.lastname: Harvard Davis
authors.forename: T C
authors.initials: TC
authors.lastname: O'Dowd
authors.forename: W
authors.initials: W
authors.lastname: Holmes
authors.forename: J
authors.initials: J
authors.lastname: Smail
authors.forename: R C
authors.initials: RC
authors.lastname: Slack
mesh_terms: D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005194:Family Practice; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D014295:Trimethoprim / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D005578:Fosfomycin; D014295:Trimethoprim