title: Comparison of antimalarial efficacy of alpha, beta, and alpha/beta arteether against Plasmodium cynomolgi B infection in monkeys.
abstract: The blood schizontocidal activity of alpha and beta arteether has been compared with that of alpha/beta arteether (a 30:70 mixture of alpha and beta isomers), which is a fast-acting blood schizontocide undergoing phase I clinical trials at the Central Drug Research Institute. Both beta and alpha/beta arteether have comparable activity and are curative at a dose of 5 mg/kg for 3 days against blood-induced Plasmodium cynomolgi B infection in the rhesus monkey; alpha arteether alone is slightly less active, with a 50% cure rate at the above dose.
authors.affiliation: Central Drug Research Institute, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Tripathi
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
authors.forename: R A
authors.initials: RA
authors.lastname: Vishwakarma
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D005260:Female; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D012717:Sesquiterpenes / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil