[Drug modulation of thromboxane A2/prostacyclin balance and lipid peroxidation in patients with coronary artery disease].
Sixty patients with coronary artery disease (CAD) were investigated in a randomized, placebo-controlled study. Therapeutic dose of diltiazem markedly inhibited the production of whole blood thromboxane A2(TXA2), but had no effect on the production of prostacyclin(PGI2). Both aspirin 20mg/d and diltiazem plus aspirin had marked inhibitive effects on both TXA2 and PGI2. The order of potency of the three regimens in decreasing TXA2/PGI2 ratio was diltiazem plus aspirin greater than diltiazem greater than aspirin. Diltiazem, aspirin and combination of both all decreased significantly serum lipid peroxides level, but had no effect on serum superoxide dismutase concentration. The results indicate that both therapeutic dose of diltiazem and low-dose of aspirin may modulate TXA2/PGI2 balance and inhibit lipid peroxidation in CAD and that the combination of both drugs may result in best therapeutic effect.
Zhao
X
X
Department of Cardiology, First Teaching Hospital, Third Military Medical College, Chongqing.
Zhang
Y H
YH
Feng
H F
HF
D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004110:Diltiazem / Q000008:administration & dosage / Q000627:therapeutic use*; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood; D013928:Thromboxane A2 / Q000097:blood*
D013928:Thromboxane A2; D011464:Epoprostenol; D013482:Superoxide Dismutase; D004110:Diltiazem; D001241:Aspirin