title: [The effect of sodium nucleinate on the population characteristics of Streptococcus groups A and C].
abstract: The influence of sodium nucleinate on the growth kinetics, streptokinase activity and virulence of streptococcal populations, groups A and C, was studied. As revealed in these studies, the kinetics of the growth of the populations of both strains in the exponential phase did not depend on the concentration of sodium nucleinate in the culture medium. Measurements made on hours 15, 20 and 24 of growth showed the presence of close, direct and statistically significant correlation between the content of biomass, as well as streptokinase activity and specific streptokinase activity, and the concentration of sodium nucleinate in the culture medium. On the basis of the calculation of the coefficients of determination, the main part (70-96%) of the total dispersion of each of the above-mentioned characteristics dispersion of each of the above-mentioned characteristics could be attributed to variations in the concentration of sodium nucleinate. Five passages of faintly virulent streptococcal strains, groups A and C, were not accompanied by a rise in their virulence.
authors.forename: A P
authors.initials: AP
authors.lastname: Khodyrev
authors.forename: B I
authors.initials: BI
authors.lastname: Feĭgel'man
authors.forename: N M
authors.initials: NM
authors.lastname: Shashkova
authors.forename: M M
authors.initials: MM
authors.lastname: Nemirovich-Danchenko
mesh_terms: D000818:Animals; D007928:Lethal Dose 50; D051379:Mice; D009696:Nucleic Acids / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity; D013300:Streptokinase / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014774:Virulence / Q000187:drug effects
chemical_list: D009696:Nucleic Acids; D012331:RNA, Fungal; C013683:sodium nucleinate; D013300:Streptokinase
vernacular_title: Vliianie nukleinata natriia na populiatsionnye kharakteristiki streptokokkov grupp A i C.