title: Position-effect variegation after 60 years.
abstract: Position-effect variegation in Drosophila--the mosaic expression of a gene placed adjacent to a junction between euchromatin and heterochromatin--remains an enigma. However, new insights are being gained from recent studies of genetic modifiers, new model systems, and variegating genes showing exceptional behavior.
authors.affiliation: Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA.
authors.forename: S
authors.initials: S
authors.lastname: Henikoff
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure; D004330:Drosophila / Q000235:genetics*; D015870:Gene Expression; D006570:Heterochromatin / Q000648:ultrastructure*; D009030:Mosaicism
chemical_list: D006570:Heterochromatin