Effect of ciclosporin A on epidermal keratinocytes in vitro: lack of a direct effect on calmodulin.
Calmodulin, a major calcium-binding protein, is important in the regulation of cell proliferation. In human keratinocytes we found that culture confluence was accompanied by a decrease in calmodulin content. Ciclosporin A, 1-10 micrograms/ml, was found to inhibit the proliferation of the cells but did not affect their calmodulin content as measured by bioassay or radioimmunoassay.
Fairley
J A
JA
Department of Dermatology, University of Rochester School of Medicine and Dentistry, N.Y.
Fung
P D
PD
Ewing
N M
NM
D002147:Calmodulin / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry / Q000187:drug effects*
D002147:Calmodulin; D003524:Cyclosporins