Post-translation modifications of neural cell surface molecules.
Neural cells seem to express a relatively low number of adhesion molecules at their surface. The hypothesis of cell surface modulation postulates that a repertoire of specificities and binding affinities might result from alteration over time of the amount, distribution or chemical properties of a particular kind of molecules. We are describing two post-translational modifications; glycosylation and glypiation; which affect the neural cell adhesive molecule (N-CAM). We produced a monoclonal antibody recognizing only the highly sialyled of N-CAM and reported some of its applications. We also showed that N-CAM-120 is anchored to the membranes via a complex glycane-phosphatidylinositol.
Rougon
G
G
Institut de Chimie Biologique, Université de Provence, Marseille.
Nédélec
J
J
Malapert
P
P
Goridis
C
C
Chesselet
M F
MF
D000818:Animals; D001921:Brain / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D004622:Embryo, Mammalian; D006031:Glycosylation; D051379:Mice; D011499:Protein Processing, Post-Translational; D051381:Rats
D015816:Cell Adhesion Molecules, Neuronal