title: [A case of late neonatal hemorrhagic disease associated with intolerance for cow's milk proteins].
abstract: The authors describe a two months aged patient affected by cow's milk protein intolerance (CMPI) with serious haemorrhagic manifestations. As blood coagulative laboratory findings demonstrated a prolongation of P.T. and P.T.T. with a marked reduction of vitamin K-dependent factors only, the authors believe these bleeding manifestations secondary to a case of late haemorrhagic disease of the newborn. Vitamin K treatment determined a rapid normalization of haemorrhagic symptoms and laboratory clotting tests, without any alteration of these ones during the patient's follow-up too. The authors suggest that blood coagulative pattern must be investigated in all CMPI cases, especially in the ones with a precocious onset of clinical symptoms. In the cases with vitamin K-dependent factors deficiency the treatment is immediately necessary, while in other cases a daily dietary supplementation or a vitamin K weekly or monthly injection could be enough in order to prevent any further vitamin K-dependent factors deficiency.
authors.affiliation: Clinica Pediatrica 2a, Università di Catania, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Fichera
authors.forename: A
authors.initials: A
authors.lastname: D'Agata
authors.forename: G
authors.initials: G
authors.lastname: Praticò
authors.forename: R
authors.initials: R
authors.lastname: Curreri
authors.forename: F
authors.initials: F
authors.lastname: Sciacca
mesh_terms: D001780:Blood Coagulation Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016269:Milk Hypersensitivity / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D008894:Milk Proteins / Q000009:adverse effects*; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D006475:Vitamin K Deficiency Bleeding / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D008894:Milk Proteins; D014812:Vitamin K
vernacular_title: Su un caso di malattia emorragica neonatale tardiva associata ad intolleranza alle proteine del latte vaccino.