Hepatic bioactivation of 4-vinylcyclohexene to ovotoxic epoxides.
Smith
B J
BJ
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721.
Mattison
D R
DR
Sipes
I G
IG
D000818:Animals; D001711:Biotransformation; D002470:Cell Survival / Q000187:drug effects; D003510:Cyclohexanes / Q000493:pharmacokinetics / Q000633:toxicity*; D053138:Cyclohexenes; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009865:Oocytes / Q000187:drug effects*; D051381:Rats; D013045:Species Specificity; D014753:Vinyl Compounds / Q000493:pharmacokinetics / Q000633:toxicity
D003510:Cyclohexanes; D053138:Cyclohexenes; D014753:Vinyl Compounds; C013733:4-vinylcyclohexene; C012606:4-vinyl-1-cyclohexene dioxide