title: [Fetal hemolytic disease in a patient immunized by six antibodies: diagnosis and treatment].
abstract: A case of severe haemolytic disease of the fetus due to six rare alloantibodies is described. In a pregnant women at 23 weeks gestation after the finding of a positive indirect Coombs test maternal antibodies have been precisely identified and titrated: anti-I: 1/23, anti-c: 1/64, anti-S: 1/16, anti-Fya: 1/128, anti-M: 1/64, anti-Jka: 1/32000. Fetal blood group, free and red blood cell adherent antibodies have been investigated on fetal blood samples obtained by means of cord centesis. A compatible donor has been found. Severe fetal anemia has been corrected by ultrasound guided intrauterine transfusions (one abdominal and two intravascular transfusions) with positive outcome of the pregnancy.
authors.affiliation: Istituti Clinici di Perfezionamento Centro Trasfusionale e di Immunoematologia, Università di Milano.
authors.forename: V
authors.initials: V
authors.lastname: Tantalo
authors.forename: E
authors.initials: E
authors.lastname: Rossi
authors.forename: G A
authors.initials: GA
authors.lastname: Gianotti
authors.forename: R
authors.initials: R
authors.lastname: Morotti
authors.forename: G
authors.initials: G
authors.lastname: Zuliani
authors.forename: M
authors.initials: M
authors.lastname: Buscaglia
authors.forename: M
authors.initials: M
authors.lastname: Galligani
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
chemical_list: D007518:Isoantibodies
vernacular_title: Malattia emolitica fetale in una paziente immunizzata da sei anticorpi: diagnosi e trattamento.