Pathophysiological basis of the treatment of ischemic heart disease.
In this paper we review the main mechanisms leading to primary and secondary ischemic attacks, the clinical manifestations of ischemic heart disease as well as the goals of treatment. Particular attention is paid to the neurohormonal regulation of coronary blood flow. The most recent advances in this field, achieved in our laboratory too, should permit important progress in the treatment of ischemic disease. The influence of chemical mediators on coronary circulation and the pathophysiological and therapeutic aspects of myocardial reperfusion injury and silent myocardial ischemia are also discussed. Finally, we present our experience with two modern therapeutic approaches to ischemic heart disease: coronary angioplasty and thrombolytic therapy.
Condorelli
M
M
I Clinica Medica, II Facoltà di Medicina e Chirurgia, Università degli Studi, Napoli, Italy.
D000787:Angina Pectoris / Q000503:physiopathology; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006801:Humans; D015912:Thrombolytic Therapy