[Effects of cefpirome sulfate on male sexual development in rats].
Cefpirome sulfate (CPR) was administered subcutaneously at 200, 500, and 1000 mg/kg/day to male rats for 5 weeks from 6 through 40 days of age and examinations were made to determine whether the antibiotic caused any detrimental effects on male sexual development when administered to juvenile rats. Cefotetan (CTT) was given at 1000 mg/kg/day as a positive control. Incrustation occurred at the injection site during administration in all treated groups. The CPR groups had no compound related changes in fertility, spermatozoa, and reproductive organs, while the CTT group showed decreased testicular weight, abnormal fertility and spermatozoa, and atrophied germinal epithelium of seminiferous tubules, atrophied epididymis, and decreased number of spermatozoa. From the results of this investigation, it may be concluded that CPR had no effects on male sexual development when administered to juvenile rats.
Akaike
M
M
Pharma Research Laboratories, Hoechst Japan Limited, Saitama.
Inazu
M
M
Ohno
H
H
Takayama
K
K
Omosu
M
M
Kobayashi
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002511:Cephalosporins / Q000633:toxicity*; D005298:Fertility / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D012741:Sexual Maturation / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome