Erythroleukemia in a child associated with monosomy 7.
A case of erythroleukemia (EL) associated with monosomy 7 is reported. The EL was diagnosed 20 months after the initial diagnosis of monosomy 7 was made. An immunologic study of the blast cells using a monoclonal antibody was positive for glycophorin A, which suggested that they were of erythroid origin; this was confirmed by electron microscopy. Chemotherapy was started with low dose cytarabine. However, the patient had severe bone marrow suppression and died of pneumonia. Our case shows that monosomy 7 is an abnormality of the pluripotential stem cells, including erythroid cells, that resulted in a true erythroid neoplasm.
Shitara
T
T
Department of Pediatrics, Gunma University School of Medicine, Japan.
Yugami
S
S
Sotomatu
M
M
Oshima
Y
Y
Ijima
H
H
Kuroume
T
T
D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D004912:Erythrocytes / Q000737:chemistry / Q000648:ultrastructure; D004920:Erythropoiesis; D006021:Glycophorins / Q000032:analysis; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D008297:Male; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000150:complications
D006021:Glycophorins