[Effect of postprandial lipoprotein fractions on the fibrinolytic system].
Plasma was obtained from fasting normolipemic healthy donors, 150 minutes past fat intake (1 g/kg body weight). Lipoproteins were isolated by sequential and density gradient ultracentrifugation. All lipoprotein fractions from fasting plasma did not show any inhibitory effect of fibrinolysis, whereas postprandial triglyceride-rich fractions (chylomicrons and VLDL) showed inhibitory effects of plasmin induced fibrinolysis. The inhibitor was identified as alpha-2-antiplasmin associated with chylomicrons and VLDL but lipoproteins itself are not responsible for inhibitory effect. It is possible that association is responsible for elevation of alpha-2-antiplasmin in patients with hypertriglycidemia.
Siegert
G
G
Institut für klinische Chemie und Laboratoriumsdiagnostik, Medizinische Akademie Dresden.
D002914:Chylomicrons / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides
Einfluss postprandialer Lipoproteinfraktionen auf das Fibrinolysesystem.