Mechanisms for pyrrolizidine alkaloid activation and detoxification.
Buhler
D R
DR
Toxicology Program, Oregon State University, Corvallis 97331.
Miranda
C L
CL
Kedzierski
B
B
Reed
R L
RL
D000818:Animals; D001711:Biotransformation; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D016686:Monocrotaline / Q000031:analogs & derivatives*; D011763:Pyrrolizidine Alkaloids / Q000378:metabolism / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D011763:Pyrrolizidine Alkaloids; C056840:senecionine N-oxide; D016686:Monocrotaline; C009237:senecionine; D005978:Glutathione; C007241:dehydroretronecine