[Estradiol binding by serum proteins in the postmenopause of women with breast cancer].
It has been established by Scatchard's plots that in breast cancer women the association constant (Ka) and the number of receptor sites (N) at binding of estradiol to serum proteins are changed considerably as compared to those in clinically healthy persons (the control group) Ka is increased and N is diminished. A higher level of free serum estradiol was measured by RIA in breast cancer patients. Serum gel filtration in column showed a decrease in globulin binding and an increase in the level of the albumin-bound labeled ligand as compared to the controls.
Nikolov
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Dimitrov
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D001798:Blood Proteins / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood*; D002850:Chromatography, Gel; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D011485:Protein Binding; D011869:Radioligand Assay; D011959:Receptors, Estradiol / Q000032:analysis / Q000378:metabolism
D001798:Blood Proteins; D011959:Receptors, Estradiol; D004958:Estradiol
Sviazyvanie éstradiola belkami syvorotki v postmenopauze u zhenshchin s rakom molochnoĭ zhelezy.