Transvaginal sonographic assessment of follicular and endometrial growth in spontaneous and clomiphene citrate cycles.
OBJECTIVE
Assessment of follicular development and endometrial growth using transvaginal sonography in spontaneous and clomiphene citrate (CC) cycles with a spontaneous luteinizing hormone surge.


METHODS
Prospective study of a spontaneous cycle followed by a CC cycle to compare paired data.


METHODS
Institutional tertiary referral infertility clinic.


METHODS
Eighteen couples with primary unexplained infertility voluntarily recruited from the infertility clinic.


METHODS
Daily transvaginal sonography and endocrine monitoring. Clomiphene citrate (150 mg) was administered on days 5 to 9 of CC cycle.


METHODS
Leading follicular diameter and endometrial thickness.


RESULTS
The growth rate of the leading follicle was similar in both study cycles, although in CC cycles the leading follicle diameter was significantly larger. Endometrial thickness was reduced in CC cycles.


CONCLUSIONS
Follicular development and endometrial thickness are altered in CC cycles.
Randall
J M
JM
Department of Obstetrics and Gynaecology, University of Aberdeen, Maternity Hospital, Scotland.
Templeton
A
A
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage*; D004717:Endometrium / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D011446:Prospective Studies; D014463:Ultrasonography / Q000379:methods*; D014621:Vagina
D002996:Clomiphene; D004958:Estradiol; D007986:Luteinizing Hormone