title: Idioventricular rhythm: hypervagotonia associated with placebo.
abstract: We report a case of hypervagotonia manifested by idioventricular rhythm in a healthy, athletic man who participated in a Phase I study of an investigational calcium-channel blocker. Upon breaking the study's double-blind study code, it was discovered that the subject had received placebo. We discuss this unusual finding and the implications of including athletic subjects in safety/tolerance studies.
authors.affiliation: California Clinical Trials, Beverly Hill, CA.
authors.forename: N R
authors.initials: NR
authors.lastname: Cutler
authors.forename: A H
authors.initials: AH
authors.lastname: Heller
authors.forename: N M
authors.initials: NM
authors.lastname: Kurtz
authors.forename: J J
authors.initials: JJ
authors.lastname: Sramek
authors.forename: T E
authors.initials: TE
authors.lastname: Lynch
authors.forename: P P
authors.initials: PP
authors.lastname: Zolnouni
authors.forename: D K
authors.initials: DK
authors.lastname: Gandhi
authors.forename: S
authors.initials: S
authors.lastname: Sawin
mesh_terms: D016170:Accelerated Idioventricular Rhythm / Q000139:chemically induced*; D000328:Adult; D003389:Cranial Nerve Diseases / Q000139:chemically induced; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos / Q000009:adverse effects*; D014630:Vagus Nerve / Q000187:drug effects*
chemical_list: D010919:Placebos