Cyclosporin nephrotoxicity.
Nephrotoxicity must always be excluded as a cause of renal dysfunction in allograft recipients receiving cyclosporin. Prolonged nephrotoxicity will lead to permanent impairment of renal function. This is a consequence of the renal vasospasm and vascular pathology that leads to ischemia and atrophy of the glomeruli and renal tubules.
Neild
G H
GH
Department of Renal Medicine, University College and Middlesex School of Medicine, St Philip's Hospital, London, U.K.
D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000187:drug effects*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D012079:Renal Circulation / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D003524:Cyclosporins