Selective inducers of the Coh-locus enhance the metabolisms of coumarin- and of quinoline-derivatives but not that of naphthalenes.
Netter
K J
KJ
Institute of Pharmacology and Toxicology, Philipps-University, Marburg, FRG.
Hahnemann
B
B
Mangoura
S A
SA
Feil
F
F
Tegtmeier
M
M
Mayer
R T
RT
Legrum
W
W
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D003374:Coumarins / Q000378:metabolism; D065637:Cytochrome P-450 CYP2A6; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics*; D004790:Enzyme Induction; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000096:biosynthesis / Q000235:genetics*; D015394:Molecular Structure; D009281:Naphthalenes / Q000378:metabolism; D011804:Quinolines / Q000378:metabolism; D013379:Substrate Specificity
D003374:Coumarins; D009281:Naphthalenes; D011804:Quinolines; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6