title: Gallbladder emptying following cholecystokinin and fatty meal in normal subjects.
abstract: A quantitative study of gallbladder emptying using 99mTc-HIDA as a bile tracer was performed with either CCK or a fatty meal as gallbladder stimulant. Its aims were to establish; (1) the reproducibility of CCK- and fatty-meal-induced gallbladder contraction, and (2) temporal patterns of gallbladder emptying following a physiological meal. Nineteen healthy, fasted volunteers were selected for 3-minute CCK administration (IV Boots Pancreozymin 2CHR units/kg) or a 40 g fatty meal. Each underwent repeat scans not less than 14 days after the first. Quantitative activity/time curves were drawn with computer analysis establishing gallbladder ejection fractions (GBEF) for each stimulus. Our results demonstrated: (1) poor reproducibility of CCK-induced gallbladder contraction precluding its diagnostic use, (2) improved but still variable meal-induced gallbladder contraction, and (3) evidence for a neurocephalic emptying response with a fatty meal stimulus.
authors.affiliation: Department of Surgery, Western Infirmary, Glasgow.
authors.forename: G M
authors.initials: GM
authors.lastname: Fullarton
authors.forename: A C
authors.initials: AC
authors.lastname: Meek
authors.forename: H W
authors.initials: HW
authors.lastname: Gray
authors.forename: R G
authors.initials: RG
authors.lastname: Bessent
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007098:Imino Acids; D008297:Male; D015609:Organotechnetium Compounds; D011897:Random Allocation; D012016:Reference Values; D019780:Technetium Tc 99m Lidofenin; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019780:Technetium Tc 99m Lidofenin; D002766:Cholecystokinin