[New derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepine-11-ones with anticholinergic activity].
Starting from 2-aminobenzoic acid and correspondingly substituted 2-chloronitrobenzenes, 5-substituted-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin -11- one derivatives with a differently high activity on ulcers were prepared. 8-Chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)a-minoacetyl]-11H- dibenzo[b,e][1,4]diazepin-11-one hydrochloride (AWD 26-06) was selected for further clinical evaluation.
Rüger
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Geschäftsbereich Forschung und Entwicklung Arzneimittelwerk Dresden GmbH.
Röhnert
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Lohmann
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D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D003984:Dibenzazepines / Q000138:chemical synthesis; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D001570:Benzodiazepinones; D003984:Dibenzazepines; D010276:Parasympatholytics; C060713:AWD 26-06
Neue Derivate des 5,10-Dihydro-11H-dibenzo[b,e][1,4]diazepin-11-on mit anticholinerger Wirkung.