[Activity of alkaline phospholipase A in lysosomes and mitochondria in damaged rabbit myocardium].
Alkaline phospholipases A were studied in rabbit myocardium under normal conditions and in heart impairment of various etiology. In mitochondrial fraction activity of phospholipase A was increased with elevation of Ca2+ concentration, while the enzyme was Ca2(+)-independent in lysosomes. Hemodynamic overloading of heart, acute local myocardial ischemia and diphtheritic intoxication led to an increase (2-4-fold) of mitochondrial phospholipases A activity with simultaneous decrease of the enzymatic activity in lysosomal membranes.
Efimova
L V
LV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008247:Lysosomes / Q000201:enzymology*; D008929:Mitochondria, Heart / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D010713:Phosphatidylcholines / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism*; D011817:Rabbits
D010713:Phosphatidylcholines; D010741:Phospholipases A; D002118:Calcium
Aktivnost' shchelochnykh fosfolipaz A lizosom i mitokhondriĭ v povrezhdennom miokarde krolikov.