title: Sequential histopathologic alterations in Indian childhood cirrhosis treated with d-penicillamine.
abstract: Eight children who satisfied all the diagnostic criteria of classic Indian childhood cirrhosis were treated with d-penicillamine. Clinical recovery in a 3- to 12-month period was accompanied histopathologically by accentuation of micronodules with regression of hepatocytic degenerative changes, Mallory's hyaline, pericellular fibrosis, lobular inflammation, and disappearance of hepatocytic copper staining protein. The nodules in the posttreatment biopsies were so small as to be categorized as "micronodular cirrhosis." In one case clinical recovery was associated with an almost normal liver histology after passing through a micronodular phase. This report is the first documentation of the histologic sequence of changes in Indian childhood cirrhosis on d-penicillamine treatment.
authors.affiliation: Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: S R
authors.initials: SR
authors.lastname: Bhusnurmath
authors.forename: B N
authors.initials: BN
authors.lastname: Walia
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: D
authors.initials: D
authors.lastname: Parkash
authors.forename: B D
authors.initials: BD
authors.lastname: Radotra
authors.forename: R
authors.initials: R
authors.lastname: Nath
mesh_terms: D003300:Copper / Q000506:poisoning; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*
chemical_list: D003300:Copper; D010396:Penicillamine