[The role of intercellular interactions in the activation of T-lymphocyte colony precursors].
The influence of the previous cultivation of human peripheral blood mononuclear cells in suspension with mitogen on the consequent PHA-stimulated response in suspension and agar cultures was studied. It has been established that proliferative response of mononuclear cells in suspension with mitogen is not changed, but the intensity of T-cell colony formation in two-layer agar systems in increased after preincubation mainly at the expense of increasing the number of type II colonies and clusters. It is concluded that the free cell-cell contacts are needed to activate T-lymphocyte colony precursors.
Sakhno
L V
LV
Shubinskiĭ
G Z
GZ
Lozovovoĭ
V P
VP
D002450:Cell Communication / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects
D010835:Phytohemagglutinins
Rol' mezhkletochnykh vzaimodeĭstviĭ v protsesse aktivatsii predshestvennikov T-limfotsitarnykh koloniĭ.