[The cardiotropic, hypometabolic and hypothermic activity of peptide fractions from the tissues of hibernating cold-adapted animals].
From tissues of hibernating and active long-tailed ground squirrels and from the brain of cold-adapted Yakut horses, low molecular peptide fractions were obtained which, after injection to albino mice, decreased oxygen consumption and rectal temperature in them. The same fractions exhibited negative chrono- and inotropic effects on isolated hearts of ectothermic and endothermic animals. Fractions from the brain of ground squirrels and the brain of horse exhibited similar pattern of the activity. The activity of fractions was subjected to seasonal changes and depended on the degree of their purification. Provisional intracellular microelectrophysiological analysis of the effect of these fractions on the frequency and strength of contractions in isolated heart was made.
Sukhova
G S
GS
Ignat'ev
D A
DA
Akhremenko
A K
AK
Levashova
V G
VG
Mikhaleva
I I
II
Sviriaev
V I
VI
Anufriev
A I
AI
Ziganshin
R Kh
RKh
Kramarova
L I
LI
Gnutov
D Iu
DIu
D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D003080:Cold Temperature; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006605:Hibernation / Q000502:physiology*; D006736:Horses; D066298:In Vitro Techniques; D051379:Mice; D008970:Molecular Weight; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits; D011896:Rana temporaria; D012589:Sciuridae; D012621:Seasons
D010446:Peptide Fragments
Kardiotropnaia, gipometabolicheskaia i gipotermicheskaia aktivnost' peptidnykh fraktsiĭ iz tkaneĭ zimospiashchikh kholodoadaptirovannykh zhivotnykh.