title: Rheoencephalographic and electroencephalographic studies on flunarizine.
abstract: The effect of flunarizine on the rheoncephalogram (REG) and on spontaneous electroencephalographic activity (EEG) was studied in acute experiments in cats. The following REG parameters were assayed: amplitude, anacrotic section of the curve and its relative part, and dicrotic index. EEG spectra were derived from 10-sec samples of EEG and the relative amplitudes were estimated at 2 Hz-intervals from 0-40 Hz. The REG study showed that flunarizine (2.5 and 5 mg/kg i.v.) caused an increase of the amplitude and a decrease of the anacrote, of its relative part, and the dicrotic index, changes indicating a lowering of the cerebrovascular resistance. EEG study showed a decrease of the amplitudes of the alpha-frequency band, and an increase of the fast-waves amplitudes, most pronounced at 5 mg/kg, changes showing enhancement of the activation processes in the brain cortex.
authors.affiliation: Institute of Neurology, Psychiatry and Neurosurgery, Medical Academy, Sofia, Bulgaria.
authors.forename: R
authors.initials: R
authors.lastname: Tsikalova
authors.forename: R
authors.initials: R
authors.lastname: Nikolov
authors.forename: M
authors.initials: M
authors.lastname: Nikolova
mesh_terms: D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005444:Flunarizine / Q000494:pharmacology*; D008297:Male; D012212:Rheology; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005444:Flunarizine