Effect of a highly selective central CCK-B receptor agonist: BC-264 on rat sleep.
The possible involvement of the CCK-B receptor type in the atypical somnolence and EEG changes induced by low doses of CCK-B was investigated by intraperitoneal administration of three different doses (8, 16 and 32 micrograms/kg) of the new highly potent and selective CCK-B agonist, BC-264, on sleep parameters in the fasted rat. At the dose of 8 micrograms/kg BC-264 induced a significant increase in waking in the second 120 min of recording without effect on slow wave sleep (SWS). BC-264 did not modify the others sleep parameters. Taken all together these results suggest that CCK-B type receptors are probably not critically involved in satiety and sleep.
de Saint Hilaire
Z
Z
Neurobiologie des Régulations, CNRS UA 637, Collège de France, Paris.
Roques
B P
BP
Nicolaïdis
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S
D000595:Amino Acid Sequence; D000818:Animals; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*
C084553:BC 264; D010446:Peptide Fragments; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin