New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae).
New antitumor clerodane diterpenes, named casearins A-F, have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). These structures have been completely elucidated by two dimensional nuclear magnetic resonance, circular dichroism spectroscopy, X-ray analysis, and chemical evidences.
Itokawa
H
H
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Totsuka
N
N
Morita
H
H
Takeya
K
K
Iitaka
Y
Y
Schenkel
E P
EP
Motidome
M
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D006224:Cricetinae; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000032:analysis*; D012510:Sarcoma 180 / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes