[Intrinsic and extrinsic factors implicated in cell proliferation of vascular smooth muscle in hypertension and diabetes].
The increased potential for growth of vascular smooth muscle cells in one of the key abnormalities in the development of essential hypertension, diabetic microangiopathy and atherosclerosis. The underlying mechanisms seem to be extrinsic (increased platelet-derived growth factor-like activity) and intrinsic (increased rate of growth, greater maximal response to growth factors and less contact inhibition). In this article, the authors discuss the primary role of an alteration in vascular smooth muscle cellular proliferation in hypertension, the extrinsic growth factors contained in platelet extracts of diabetic and hypertensive subjects and the specific effects of insulin and antihypertensive therapy on this pro-mitotic platelet activity. The result of experimental studies in our laboratory and in other studies suggest that genetic factors and therapeutic intervention could control the growth of vascular smooth muscle cells and that further evaluation of anti-hypertensive therapy may be necessary.
Hadrava
V
V
Laboratoire de physiopathologie moléculaire, Institut de recherches cliniques, Montréal, Québec, Canada.
Russo
C R
CR
Kruppa
U
U
Lacourcière
Y
Y
Tremblay
J
J
Hamet
P
P
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D002455:Cell Division; D003920:Diabetes Mellitus / Q000473:pathology* / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR
Facteurs intrinsèques et extrinsèques impliqués dans la prolifération cellulaire de la musculature vasculaire lisse dans l'hypertension et le diabète.