Influenza vaccine: enhancement of immune response by application of carboxy-vinylpolymer.
We evaluated the possibility of application of carboxy vinylpolymer (CVP) to influenza vaccine for the improvement of immune response. Our result shows that CVP induces good immune responses after inoculation of vaccines to mice both subcutaneously, intraperitoneally, and intranasally. Considering the efficacy and safety, intranasal administration of the CVP-coupled vaccine may be the best route of immunization.
Oka
T
T
Chemo-sero-therapeutic Research Institute, Kumamoto, Japan.
Honda
T
T
Ohkuma
K
K
Sakoh
M
M
Nonaka
S
S
D000281:Administration, Intranasal; D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology*; D002642:Chick Embryo; D005260:Female; D006385:Hemagglutination Inhibition Tests; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000494:pharmacology*
D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D011109:Polymethacrylic Acids