title: In vitro activity of sparfloxacin (AT-4140, CI-978, PD 131501), a new quinolone antimicrobial agent.
abstract: In vitro activity of sparfloxacin (AT-4140, CI-978, PD 131501) against clinical bacterial isolates was compared with those of ciprofloxacin and vancomycin or imipenem. Sparfloxacin was more active or equal to ciprofloxacin against most Gram-positive species and against Bacteroides fragilis, and it inhibited virtually all Enterobacteriaceae at 1.0 micrograms/ml or less.
authors.affiliation: Department of Medicine, New England Deaconess Hospital, Boston, MA 02115.
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: K
authors.initials: K
authors.lastname: Klimm
authors.forename: M L
authors.initials: ML
authors.lastname: Grayson
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D014640:Vancomycin; D015378:Imipenem; C061363:sparfloxacin