title: The influence of zinc administration on the development of experimental lung metastases after an injection of tumour cells into the tail vein of rats.
abstract: Rats having received drinking water enriched with zinc (zinc acetate, 22.8 mmol/l) developed significantly more pulmonal metastases after an i.v. injection of 5 x 10(5) cultivated cells of a benzpyrene-induced sarcoma than receiving normal drinking water. Zinc ions seem to promote the emigration, implantation and outgrowth of circulating tumour cells.
authors.affiliation: Institute of Pathology, Martin Luther University Halle-Wittenberg, FRG.
authors.forename: F W
authors.initials: FW
authors.lastname: Rath
authors.forename: R
authors.initials: R
authors.lastname: Körtge
authors.forename: P
authors.initials: P
authors.lastname: Haase
authors.forename: M
authors.initials: M
authors.lastname: Bismarck
mesh_terms: D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000556:secondary*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000473:pathology / Q000556:secondary*; D013623:Tail / Q000098:blood supply; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D015032:Zinc