Amino acids with central pressor effect in conscious rats.
Intracisternal injection of arginine, proline, cysteine, aspartic acid, and asparagine increased blood pressure in conscious rats. Proline markedly decreased heart rate, but the rate was raised by arginine, cysteine, and aspartic acid. In addition, intravenous administration of these amino acids failed to increase blood pressure in the same pattern.
Takemoto
Y
Y
Department of Physiology, Hiroshima University School of Medicine, Japan.
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001216:Asparagine / Q000494:pharmacology; D001224:Aspartic Acid / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D011392:Proline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D001224:Aspartic Acid; D001216:Asparagine; D001120:Arginine; D011392:Proline; D003545:Cysteine