[Blood levels of vitamin E, polyunsaturated fatty acids of phospholipids, lipoperoxides, glutathione peroxidase activity and serological screening for syphilis and HIV in immigrants from developing countries].
Plasma levels of vitamin E (Vit E), polyunsaturated fatty acids of phospholipids (PUFA-PL), lipoperoxides as well as erythrocytes glutathione peroxidase activity (GSH-Px), were evaluated in 200 migrants coming from developing countries, some of which at high risk for serious infective diseases. HIV-1 and syphilis infections were also investigated. 114 subjects (57%) had blood levels of Vit E, PUFA-PL and GSH-Px significantly lower (p less than 0.001, p less than 0.01) than those of normal healthy individuals (n = 30), while lipoperoxides values were unchanged. 8 from this group were found to be HIV-1 positive, and 5 TPHA positive. In contrast, the remaining 86 migrants did not show any signs of infections and their blood parameters were normal enough. These results show that factors such as widespread poverty, inadequate housing, malnutrition, insufficient access to medical care, psychological stress are strictly correlated to the reduction of blood parameters which are critical for the normal cell function of mammalian cells. PUFA-PL deficiency may cause lesions likely due to faulty cellular membranes. The lack of Vit E and GSH-Px, which are considered major protective molecules against lipoperoxidation damage in vivo, has been involved in several human diseases. We suggest that low blood levels of Vit E, GSH-Px and particularly PUFA-PL may play a pathogenetic role in the onset and development of AIDS and other infections. In this connection, we have found that a deficiency of these blood parameters occurs in patients with AIDS (n = 50) and in 32% of HIV seronegative intravenous drug abusers (n = 100).
Passi
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S
Istituto Dermatologico San Gallicano, Roma.
Morrone
A
A
Picardo
M
M
De Luca
C
C
Bartoli
F
F
Zurlo
A
A
Ippolito
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D003906:Developing Countries; D004641:Emigration and Immigration; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007558:Italy; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D010743:Phospholipids / Q000097:blood; D013587:Syphilis / Q000517:prevention & control*; D014810:Vitamin E / Q000097:blood*
D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D010743:Phospholipids; D014810:Vitamin E; D005979:Glutathione Peroxidase
Livelli ematici di vitamina E, acidi grassi poliinsaturi dei fosfolipidi, lipoperossidi, attività glutatione perossidasica e screening sierologico per sifilide e HIV in immigrati extracomunitari di colore.