Ionising radiations from nuclear establishments and childhood leukaemias--an enigma.
The Gardner report, recently published in the UK, showing a correlation between incidence of childhood leukaemia and paternal exposure to ionising radiations (amongst fathers working in nuclear power plants) has added a new element to debates about both the risk factors in nuclear power plants and the relationships between ionising radiations and leukaemogenesis. The epidemiologic and genetic evidence concerning leukaemias is reviewed here and it is concluded that the leukaemogenic agent, whose existence is indicated in the Gardner report, is unlikely to be paternal radiation dose per se but rather exposure to another factor that is correlated with parternal radiation dose received.
Evans
H J
HJ
Human Genetics Unit, Western General Hospital, Edinburgh, UK.
D002648:Child; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D009688:Nuclear Reactors; D011519:Proto-Oncogenes; D011839:Radiation, Ionizing; D006113:United Kingdom