Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.
The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.
Baxevanis
C N
CN
Department of Immunology, Hellenic Anticancer Institute, Athens, Greece.
Frillingos
S
S
Seferiadis
K
K
Reclos
G J
GJ
Arsenis
P
P
Katsiyiannis
A
A
Anastasopoulos
E
E
Tsolas
O
O
Papamichail
M
M
D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D007519:Isoantigens / Q000008:administration & dosage; D010835:Phytohemagglutinins / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D007376:Interleukin-2; D007519:Isoantigens; D010835:Phytohemagglutinins; D011498:Protein Precursors; D015375:Receptors, Interleukin-2; C040782:prothymosin alpha; D013947:Thymosin