title: Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system (CNS).
abstract: Polyamine (PA) accumulation has been associated with blood-brain barrier (BBB) disruption and vasogenic oedema after cold injury. PAs and water content were measured in a rat spinal cord model of late-delayed radiation injury and were found to be elevated at paralysis. The elevated PA levels could be significantly reduced by treatment with difluoromethylornithine (DFMO). In unirradiated rats DFMO reduced putrescine to undetectable levels after 10-12 weeks. These data suggest that blockade of PA synthesis may be useful in treating the vasogenic oedema of radiation injury and may improve CNS radiation tolerance.
authors.affiliation: Brain Tumour Research Center, University of California, San Francisco.
authors.forename: P H
authors.initials: PH
authors.lastname: Gutin
authors.forename: M W
authors.initials: MW
authors.lastname: McDermott
authors.forename: G
authors.initials: G
authors.lastname: Ross
authors.forename: P H
authors.initials: PH
authors.lastname: Chan
authors.forename: S F
authors.initials: SF
authors.lastname: Chen
authors.forename: K J
authors.initials: KJ
authors.lastname: Levin
authors.forename: O
authors.initials: O
authors.lastname: Babuna
authors.forename: L J
authors.initials: LJ
authors.lastname: Marton
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001834:Body Water / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004487:Edema / Q000378:metabolism*; D000518:Eflornithine / Q000494:pharmacology; D005260:Female; D011188:Potassium / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012964:Sodium / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000528:radiation effects*; D013118:Spinal Cord Diseases / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001679:Biogenic Amines; D012964:Sodium; D011188:Potassium; D000518:Eflornithine