Cyclohexyladenosine reduces MPTP induced tremor in dogs.
Male dogs were injected i.v. with 1 methyl-4-phenyl-1,2,3,6-tetrahydro- pyridine (MPTP) 2.5 mg/kg twice with an interval of 6 days. Twenty minutes after MPTP injection cyclohexyladenosine (CHA) 1 mg/kg i.v. was injected. Ten minutes after CHA injection the MTPT induced tremor, tachycardia and salviation ceased.
Tal
E
E
Department of Biological Chemistry, Hebrew University, Jerusalem, Israel.
Nir
I
I
Kalman
R
R
Yanai
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D012016:Reference Values; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
C027513:N(6)-cyclohexyladenosine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000241:Adenosine