Methodological problems in treatment resistant depression research.
To better understand why treatment resistant depression (TRD) has been resistant to systematic study, the author analyzes methodologic problems facing TRD researchers with a focus on the difficulty of defining TRD. Then approaches for clinicians to interpret limited and potentially biased TRD data are suggested.
Nierenberg
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Treatment Resistant Depression Program, McLean Hospital, Harvard Medical School, Belmont, MA 02178.
D003863:Depression / Q000188:drug therapy*; D004351:Drug Resistance; D006801:Humans; D012107:Research Design