[Simultaneous administration of various model substances for characterizing in vivo biotransformation in chronic liver diseases].
16 patients with different chronic liver diseases were given single doses of the model substances caffeine, metamizol, sufamethacine and debrisoquine. This was followed by the simultaneous administration of all these substances as a "cocktail". A comparison between the single and the "cocktail" dosage did not reveal any significant differences in the pharmacokinetic parameters. So the "cocktail" administration is even possible in chronic liver diseases. Requiring relatively little time, it makes statements possible concerning various cytochrome P450 enzymes including the types of hydroxylation and acetylation. Intraindividual variations can be ruled out.
Truckenbrodt
J
J
Klinik für Innere Medizin, Friedrich-Schiller-Universität Jena.
Kraul
H
H
Huster
A
A
Töpfer
R
R
Henschel
L
L
Hoffmann
A
A
Reinhardt
M
M
Jorke
D
D
D001711:Biotransformation / Q000502:physiology*; D002110:Caffeine / Q000493:pharmacokinetics; D003647:Debrisoquin / Q000493:pharmacokinetics; D004177:Dipyrone / Q000493:pharmacokinetics; D005235:Fatty Liver, Alcoholic / Q000503:physiopathology; D005260:Female; D006521:Hepatitis, Chronic / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000503:physiopathology*; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D013418:Sulfamethazine / Q000493:pharmacokinetics
D002110:Caffeine; D013418:Sulfamethazine; D004177:Dipyrone; D003647:Debrisoquin
Die simultane Gabe verschiedener Modellsubstanzen zur Charakterisierung der in-vivo Biotransformation bei chronischen Lebererkrankungen.