Treatment of pemphigus vulgaris with cyclosporine. .
Treatment of a few severe cases of pemphigus vulgaris with ciclosporin has been reported. We describe a patient with pemphigus vulgaris of more than 3 years' duration who did not respond to prednisolone treatment in high doses nor plasmapheresis or pulse therapy with methylprednisolone. When therapy with ciclosporin (5.0 mg/kg/day) in combination with prednisolone (1.4 mg/kg/day) was given, clinical improvement was present after 1 week, and almost complete remission was seen after 11 weeks. We did not observe any side effects during 1 year of treatment except hypertrichosis and hypomagnesemia.
Bondesson
L
L
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Hammar
H
H
D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
D003524:Cyclosporins; D011239:Prednisolone