[Effects of dalargin on some parameters of peroxidation of liver lipids in experimental animals].
The cholestasis and pancreatitis model was studied experimentally in 144 white rats. The influence of intraperitoneal injections of dalargin on the level of lipid peroxidation and on xanthine oxidase activity of the liver tissues in periods of 1, 3 and 5 hours was investigated. During that period the activity of hepato-specific enzymes in the liver tissues and serum were investigated. The reduction of xanthine oxidase activity in all the periods after injection of dalargin was discovered, the level of malonic dialdehyde was reduced by 43.8% 3 hours later. Simultaneously, the increase of the level of histidase in liver tissues was discovered (on 104.3% and 56.3% after 3 and 5 hours accordingly) and later the tendency to decrease the activity in serum was observed.
Shloznikov
B M
BM
Korotkina
R N
RN
Babkina
N V
NV
Karelin
A A
AA
Fomchenkov
E P
EP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors; D014969:Xanthine Oxidase / Q000378:metabolism
D000897:Anti-Ulcer Agents; D013565:Sympatholytics; D008315:Malondialdehyde; D016308:Enkephalin, Leucine-2-Alanine; D014969:Xanthine Oxidase; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na nekotorye pokazateli perekisnogo okisleniia lipidov pecheni v éksperimente.