title: [Effect of buprenorphine on external pancreatic secretion in rats].
abstract: 2-deoxyglucose stimulates pancreatic secretion through a mainly vagal neural pathway. Buprenorphine antagonized this stimulation in a dose-related fashion between 0.017 and 0.45 mg/kg. i.v. The effect of buprenorphine was suppressed by naloxone, but not by alpha and beta-adrenoceptor blocking agents. The effect of methadone was similar, at doses about ten times larger.
authors.affiliation: INSERM U 239, Faculté de Médecine Xavier Bichat, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Nagain
authors.forename: J
authors.initials: J
authors.lastname: Chariot
authors.forename: C
authors.initials: C
authors.lastname: Roze
authors.forename: C
authors.initials: C
authors.lastname: Vaille
mesh_terms: D000818:Animals; D002047:Buprenorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D008297:Male; D008691:Methadone / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009270:Naloxone; D002047:Buprenorphine; D003847:Deoxyglucose; D008691:Methadone
vernacular_title: Action de la buprénorphine sur la sécrétion pancréatique externe chez le rat.