title: The irritable bowel syndrome.
abstract: The irritable bowel syndrome (IBS) is a familiar problem in the clinic, but as a disease entity it remains ill defined. Much confusion has arisen in the past, because of the inappropriate inclusion within the category of IBS of almost any patient with unexplained abdominal discomfort. Recent work has established that IBS patients can be positively identified by a cluster of specific symptoms. With the use of these criteria, it seems likely that IBS patients suffer from a diffuse motor abnormality of the gut associated with visceral hypersensitivity; although there is no associated psychopathology, a central nervous system component to the disorder is possible. Better insight into IBS promises more effective management.
authors.affiliation: Gastrointestinal Science Research Unit, London Hospital Medical College, England.
authors.forename: D L
authors.initials: DL
authors.lastname: Wingate
mesh_terms: D003109:Colonic Diseases, Functional / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans