Pharmacodynamics of Amlexanox (AA-673) in normal and anaphylactic rat conjunctiva and its effect on histamine concentration.
The pharmacodynamics of Amlexanox (AA-673), an azoxanthone derivative recently developed as an ocular anti-allergic drug, were studied in normal and anaphylactic rat conjunctiva. Ocular anaphylaxis was induced by topical application of dithiothreitol and antigen challenge (egg albumin). The drug concentration was measured at 5, 30, 60 and 120 min after instillation of AA-673 0.25% ophthalmic solution. Histamine concentrations in the pretreated and untreated anaphylactic conjunctiva were compared. In both groups the drug concentration decreased exponentially with time, showing a marked delay in the anaphylactic group. There was a significant difference in histamine values between the pretreated and untreated groups.
Rankov
G
G
Department of Ophthalmology, Kanazawa Medical University, Uchinada Ishikawa, Japan.
Sasaki
K
K
Fukuda
M
M
D000631:Aminopyridines / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003228:Conjunctiva / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D004229:Dithiothreitol; D006632:Histamine / Q000378:metabolism*; D006967:Hypersensitivity / Q000378:metabolism*; D008297:Male; D010047:Ovalbumin; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D006632:Histamine; D010047:Ovalbumin; C045742:amlexanox; D004229:Dithiothreitol