Promoting effect of truncal vagotomy on pancreatic carcinogenesis initiated with N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters.
The effect of truncal vagotomy (TV) on pancreatic carcinogenesis initiated with N-nitrosobis(2-oxopropyl)amine (BOP) was investigated in 81 female Syrian golden hamsters. The animals were divided into four groups according to the treatment, groups 1 and 2 serving as non-initiated controls receiving a single s.c. injection of 0.9% NaCl followed by either a sham operation or TV respectively, at week 2. Groups 3 and 4 were given a single s.c. injection of 70 mg/kg body wt of BOP before the sham operation or TV. All hamsters were killed at week 24, and the pancreas, liver and gall bladder tissues were examined histologically. While TV itself caused no significant change in pancreatic weight, the incidence of pancreatic carcinomas in hamsters from group 4 was 48.4%, significantly higher than the 16.7% evident in hamsters from group 3 (P less than 0.05). GLC analysis of the bile acid composition of gall bladder bile from hamsters not receiving carcinogen 1 and 4 months after TV revealed significantly decreased secondary bile acids. The results thus indicated that changes in bile acid composition may be involved in enhancement of BOP-initiated pancreatic carcinogenesis in hamsters by TV.
Ogawa
T
T
Department of Surgery I, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
Makino
T
T
Mizumoto
K
K
Nakayama
F
F
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002766:Cholecystokinin / Q000494:pharmacology; D006224:Cricetinae; D005260:Female; D005704:Gallbladder / Q000473:pathology; D008099:Liver / Q000473:pathology; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000209:etiology*; D015167:Vagotomy, Truncal
D001647:Bile Acids and Salts; D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine; D002766:Cholecystokinin