title: Effects of high alpha-linolenate and linoleate diets on erythrocyte deformability and hematological indices in rats.
abstract: Rats were fed either a high alpha-linolenate diet or a high linoleate diet from weaning to 4 mon of age. Soybean oil was used as a control. Phospholipid compositions of erythrocytes from the three dietary groups were not significantly different. However, the difference in the alpha-linolenate (18:3n-3)/linoleate (18:2n-6) ratio of the diets was reflected in the n-3/n-6 ratios of the 20 and 22 carbon highly unsaturated fatty acids except for docosahexaenoic acid (22:6n-3) in the phospholipids. Despite the significant differences in the fatty acid compositions of phospholipids, no measurable differences were detectable in erythrocyte deformability, whole blood viscosity and hematological indices of the three dietary groups. These results indicate that the beneficial effects of the high alpha-linolenate diet, as compared with the high linoleate diet, are exerted without significant changes in these parameters.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Okuyama
authors.forename: K
authors.initials: K
authors.lastname: Kon
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Sekiya
authors.forename: T
authors.initials: T
authors.lastname: Shiga
authors.forename: R C
authors.initials: RC
authors.lastname: Reitz
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D004907:Erythrocyte Deformability / Q000187:drug effects*; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis; D008042:Linolenic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008042:Linolenic Acids; D010743:Phospholipids; D002784:Cholesterol