Therapeutics review: the use of parenteral drugs for falciparum malaria.
Recent studies on the pharmacokinetics of parenteral chloroquine and quinine have resulted in safer regimens for the treatment of severe falciparum malaria. In this article we summarise these regimens, and discuss the emergence of chloroquine resistance and the implications for treatment.
Davidson
R N
RN
Department of Medicine, University of Zimbabwe Medical School, Avondale Harare.
Stein
C M
CM
Houston
S
S
D000818:Animals; D002738:Chloroquine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008288:Malaria / Q000188:drug therapy*; D010963:Plasmodium falciparum; D011803:Quinine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
D002738:Chloroquine; D011803:Quinine