[Hypothermia as a damaging factor in heart preservation].
To study the mechanisms of hypothermic heart damage the authors analysed changes in the energetic condition and character of restoration of the contractile activity of the rat heart after heart ischemia and hypothermic storage of various duration. In contrast to damage in heat ischemia, the degree of cardiac function disorders after hypothermic storage did not correlate with the degree of the energy disturbances. Addition of 0.5% dimethylsulfoxide to the preservative solution reduced the degree of the functional disorders and increased the admissible duration of hypothermic storage. It is believed that disorders of the function of the heart in storage under low temperature are due to a great measure to the phase transfer of the membrane lipids and impaired intramembrane protein-lipid interrelationships.
Kirpatovskiĭ
V I
VI
Frolova
E V
EV
Onishchenko
N A
NA
D000818:Animals; D006321:Heart / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D051381:Rats; D013696:Temperature
Gipotermiia kak povrezhdaiushchiĭ faktor pri konservatsii serdtsa.