Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg(2+)-free medium.
NMDA receptor-mediated process of rat neocortex slices prepared from 2-24-day-old rats were studied in Mg(2+)-free solution. The response to NMDA application as well as the susceptibility to epileptiform discharges showed age-dependent changes during the first 4 weeks. Slices from the youngest age group seemed to be the most sensitive to NMDA, whereas epileptic activity developed most readily at around the third week.
Világi
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Department of Comparative Physiology, Eötvös Loránd University, Budapest, Hungary.
Tarnawa
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Banczerowski-Pelyhe
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D000375:Aging / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000503:physiopathology*; D003470:Culture Media; D004566:Electrodes; D004594:Electrophysiology; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology; D008274:Magnesium / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000502:physiology
D003470:Culture Media; D016202:N-Methylaspartate; D007649:Ketamine; D008274:Magnesium