Possible application of polyamine graft copolymer to targeting drug delivery.
Polystyrene microspheres were coated with polyamine graft copolymer and mixed with rat lymphocyte suspension. In the mixture of T and B cells, the microspheres formed large aggregates, while they were fairly well dispersed in the T cell suspension. This result was understood to be the result of preferential adsorption of B cells to the microspheres, indicating it would be possible to deliver drugs to B cells alone with these copolymer-coated microspheres.
Muramatsu
N
N
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Yoshida
Y
Y
Kondo
T
T
D000818:Animals; D004337:Drug Carriers; D008297:Male; D008863:Microspheres; D011073:Polyamines; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains
D004337:Drug Carriers; D011073:Polyamines; D011108:Polymers