title: [Functional evaluation of the intrathoracic stomach after esophagectomy for esophageal cancer].
abstract: Sixteen patients underwent evaluation of duodenogastric reflux and gastric function 1 to 7 years after esophagectomy, high intrathoracic anastomosis, and pyloric divulsion for esophageal cancer. Ten patients (62%) had either postoperative digestive symptoms or endoscopic mucosal lesions, cholescintigraphy demonstrated duodenogastric reflux in 11 cases (69%). No gastric motor activity was recorded on manometry. 24-hour pH gastric monitoring showed that the area under the curve less than 4 was significantly less than in controls (p = 0.0003). The results of the present study show that duodenogastric reflux is a common event after esophageal replacement with the stomach. The interaction between acid and alkaline secretions plays a role in the pathogenesis of mucosal lesions, and it may explain the partial failure of the current therapeutic strategies.
authors.affiliation: Clinica Chirurgica I, Università di Padova.
authors.forename: L
authors.initials: L
authors.lastname: Bonavina
authors.forename: M
authors.initials: M
authors.lastname: Anselmino
authors.forename: A
authors.initials: A
authors.lastname: Ruol
authors.forename: N
authors.initials: N
authors.lastname: Borsato
authors.forename: A
authors.initials: A
authors.lastname: Peracchia
mesh_terms: D000368:Aged; D004383:Duodenogastric Reflux / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005746:Gastric Emptying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D013270:Stomach / Q000503:physiopathology* / Q000637:transplantation
vernacular_title: Valutazione funzionale del paziente operato di esofagectomia ed esofagogastroplastica intratoracica per cancro dell'esofago.