title: Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension.
abstract: Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urinary calcium excretion (2.5 to 3.4 mmol/L, P = .011) and an increase in serum 1,25-dihydroxyvitamin D (51.2 to 61.0 pmol/L, P = .045). An inverse correlation existed between the change in vitamin D and the change in plasma renin activity (r = -0.765, P = .01). An inverse correlation also existed between the change in plasma renin activity and the change in mean arterial blood pressure (r = -0.757, P = .011). It is postulated that the increase in dietary sodium led to an increase in serum 1,25-dihydroxyvitamin D concentration, which may have contributed to an increase in intracellular calcium concentration, a decrease in renal secretion of renin, and a fall in plasma renin activity. The resultant fall in PRA in part effected the change in blood pressure to the increased sodium intake. Therefore, 1,25-dihydroxyvitamin D may be a mediator in the response of high renin hypertension to increased sodium intake.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Calgary, Alberta, Canada.
authors.forename: E D
authors.initials: ED
authors.lastname: Burgess
authors.forename: R G
authors.initials: RG
authors.lastname: Hawkins
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism; D008297:Male; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012982:Sodium, Dietary / Q000008:administration & dosage
chemical_list: D012982:Sodium, Dietary; D012083:Renin; D002117:Calcitriol; D002118:Calcium