[Experimental study of a new calcification reducing monocusp patch].
The glutaraldehyde (GA)-treated porcine pericardium was modified chemically with epoxychlopropane (EC). Monocusp patches were made and implanted in the right ventricular outflow tract of dogs (n = 10). The GA or chloroacetic treated porcine pericardium monocusp patches was used as the control groups. At 6 months after implantation, the calcium of the samples were detected qualitatively (by von Kossa staining technique and with light microscopic observation), quantitatively (by a tomic absorption) and ultrastructurally. The stability and mechanical properties of tissue after modification with EC were assessed. The results of this study prove that chemically modified porcine pericardium with EC can reduce the calcification of tissue, and can preserve its structural intactness, good tissue stability, good tensile strength and function.
Yi
D H
DH
General Hospital of Shenyang Military Area of People's Liberation Army.
D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis / Q000517:prevention & control*; D004285:Dogs; D004811:Epichlorohydrin / Q000737:chemistry; D005260:Female; D006350:Heart Valve Prosthesis; D008297:Male
D004811:Epichlorohydrin