title: [The enzymatic system of phospholipid deacylation-reacylation in rat liver lysosomal membranes].
abstract: It has been shown for the first time that lysosomal (tritosomal) membranes of rat liver contain enzymes that are responsible for the deacylation-reacylation of phospholipids; their activity optimum lies at pH 7.0. Deacylation of lysosomal membrane phospholipids is controlled by a cascade of enzymatic reactions involving Ca2(+)-dependent phospholipase A1 which exhibits the maximal activity at 2.5 mM Ca2+ and at neutral values of pH, as well as lysophospholipase. Reacylation of lyso-derivatives of phospholipids is catalyzed by Mg2(+)-activated oleoyl-CoA:lysophosphatidylcholine acyltransferase having an activity optimum at pH 7.2.
authors.forename: T B
authors.initials: TB
authors.lastname: Batikian
authors.forename: K G
authors.initials: KG
authors.lastname: Karagezian
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Tadevosian
mesh_terms: D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000215:Acylation; D000818:Animals; D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology* / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054466:Phospholipases A1; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
chemical_list: D010743:Phospholipids; D008995:Monoamine Oxidase; D008243:1-Acylglycerophosphocholine O-Acyltransferase; D010741:Phospholipases A; D054466:Phospholipases A1; D000135:Acid Phosphatase
vernacular_title: Fermentnaia sistema deatsilirovaniia-reatsilirovaniia fosfolipidov v membranakh lizosom pecheni krys.