[The combined modulating effects of cerium nitrate with certain Chinese traditional drugs on altered cell-mediated immunities in scald mice].
Altered cell-mediated immunities (CMI) is one of the important causes of increased susceptibility to infection and, high mortality of burned patients. This paper presents the experimental work on mice with scald injury to restore their altered CMI by local application of cerium nitrate (CE) or systemic administration of Astragalus membranaceus (AM) or Lonicera japonica Thunb (LJT), as well as combination use of these drugs. The proliferative response to Con A and the ability of IL-2 production of murine spleen cells and the delayed hypersensitivity test using DNFB as sensitizer were chosen as the parameters of CMI. Results showed that CMI of untreated scald mice was suppressed to 50-60% of normal control 11 days following scald injury. While either CE used locally or AM or LJT given by oral with different dosages might bring up the depressed CMI to various degrees, near the normal level and some even above normal. When CE was used accompanied with AM or LJT, their effects on restoration of CMI were significantly better than that when any single drug was administered alone.
Luo
Z H
ZH
Burned Institute, Third Military Medical College, Chongqing.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D027885:Astragalus propinquus; D002056:Burns / Q000188:drug therapy / Q000276:immunology*; D002563:Cerium / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice
D000891:Anti-Infective Agents, Local; D004365:Drugs, Chinese Herbal; C032786:cerium nitrate; D002563:Cerium