title: Karyotypic evolution in B-cell chronic lymphocytic leukaemia.
abstract: Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B-CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18 patients (16%). There was no significant difference in the incidence of disease progression between patients with a stable karyotype and those who underwent karyotypic evolution. In only one patient was there a clear association between disease progression, a change in cell morphology and karyotypic evolution.
authors.affiliation: Department of Haematology, Royal Victoria Hospital, Bournemouth, England.
authors.forename: D
authors.initials: D
authors.lastname: Oscier
authors.forename: M
authors.initials: M
authors.lastname: Fitchett
authors.forename: T
authors.initials: T
authors.lastname: Herbert
authors.forename: R
authors.initials: R
authors.lastname: Lambert
mesh_terms: D002999:Clone Cells / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D015448:Leukemia, B-Cell / Q000235:genetics* / Q000473:pathology