title: Assessment of the reproducibility of nocturnal growth hormone secretion.
abstract: The reproducibility of measurements of nocturnal spontaneous secretion of growth hormone (GH) was assessed. The study population consisted of 15 short children with a variety of pathological conditions. Blood samples were taken every 20 min from each subject during sleep on two consecutive nights. The analysis of variance of matched series indicated a global reproducibility, but also demonstrated significant individual variabilities (with-in-subject effect) of both peak amplitude (p = 0.05) and mean concentration (p = 0.02). We did not find any link between the variation of the GH parameters and the variations of the clinical sleep score in 11 patients.
authors.affiliation: Pediatric Endocrine Unit, University Hospital, Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Weill
authors.forename: M
authors.initials: M
authors.lastname: Dherbomez
authors.forename: P
authors.initials: P
authors.lastname: Fialdes
authors.forename: C
authors.initials: C
authors.lastname: Stuckens
authors.forename: A
authors.initials: A
authors.lastname: Duhamel
authors.forename: C
authors.initials: C
authors.lastname: Ponté
mesh_terms: D000704:Analysis of Variance; D001120:Arginine; D002648:Child; D002940:Circadian Rhythm; D005260:Female; D006130:Growth Disorders / Q000097:blood*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D013006:Growth Hormone; D001120:Arginine