title: Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature.
abstract: Systemic corticosteroids may be either contraindicated or not efficacious in treating the cutaneous manifestations occurring in 20% to 35% of patients with systemic sarcoidosis. Chloroquine phosphate has been reported to be a valuable alternative therapy for cutaneous lesions of sarcoidosis. With a judiciously determined daily dosage and regular 6-month ophthalmologic follow-up examinations, the risk of developing retinopathy can be avoided, because the daily dosage rate rather than total dose accumulation determines the development of chloroquine-induced retinopathy. We reviewed the efficacy and safety of chloroquine and its role in the treatment of cutaneous sarcoidosis.
authors.affiliation: Division of Dermatology, Vanderbilt School of Medicine, Nashville, Tenn. 37232.
authors.forename: J A
authors.initials: JA
authors.lastname: Zic
authors.forename: D H
authors.initials: DH
authors.lastname: Horowitz
authors.forename: C
authors.initials: C
authors.lastname: Arzubiaga
authors.forename: L E
authors.initials: LE
authors.lastname: King
mesh_terms: D002738:Chloroquine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012507:Sarcoidosis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D002738:Chloroquine