title: Effect of in vitro Aica-P treatment on certain cellular immune functions.
abstract: The effect of the hepatoprotective agent and protein synthesis stimulator 4-amino-5-imidazole-carboxamide-phosphate on the resynthesis of the "E" receptors of T lymphocytes and on certain immunological functions was investigated in vitro. Aica-P treatment enhanced the resynthesis of the "E" receptors after trypsin digestion and inhibited the blastic transformation of the lymphocytes. The results corroborate the observations that Aica-P is able to enhance protein synthesis and to exert immunomodulatory activity.
authors.affiliation: Second Department of Internal Medicine, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Deák
authors.forename: G
authors.initials: G
authors.lastname: Müzes
authors.forename: I
authors.initials: I
authors.lastname: Láng
authors.forename: K
authors.initials: K
authors.lastname: Nékám
authors.forename: R
authors.initials: R
authors.lastname: González-Cabello
authors.forename: P
authors.initials: P
authors.lastname: Gergely
authors.forename: J
authors.initials: J
authors.lastname: Fehér
mesh_terms: D000328:Adult; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008108:Liver Diseases, Alcoholic / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000187:drug effects; D013223:Statistics as Topic; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D011971:Receptors, Immunologic; D000620:Aminoimidazole Carboxamide; C028212:aminoimidazole carboxamide phosphate