title: Urinary calculi associated with purine metabolism. Uric acid nephrolithiasis.
abstract: Uric acid stones are the consequences of abnormalities in purine metabolism, urate/uric acid renal handling, or excess dietary protein. Treatment is aimed at preventing additional formation by decreasing the degree of urate and uric acid supersaturation in urine, by altering diet, fluid intake, and the urine pH, and by blocking steps in uric acid production.
authors.affiliation: Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: A W
authors.initials: AW
authors.lastname: Williams-Larson
mesh_terms: D000228:Adenine Phosphoribosyltransferase / Q000172:deficiency; D006801:Humans; D007669:Kidney Calculi / Q000175:diagnosis; D007926:Lesch-Nyhan Syndrome / Q000175:diagnosis; D011687:Purines / Q000378:metabolism*; D012307:Risk Factors; D014527:Uric Acid / Q000378:metabolism; D014545:Urinary Calculi / Q000209:etiology* / Q000517:prevention & control; D014969:Xanthine Oxidase / Q000172:deficiency
chemical_list: D011687:Purines; D014527:Uric Acid; D014969:Xanthine Oxidase; D000228:Adenine Phosphoribosyltransferase