[Benzisoselenazolinones and their derivatives, a new series of anti-inflammatories and antioxidants].
Ebselen, a benzisoselenazolinone, displays antiinflammatory properties and antioxidant capacity similar to the enzyme glutathione peroxydase. Structural modifications were realized. The presence of substituents ortho to selenium, and in particular of a dipolar group such as -NO2, led to an interesting modification of the pharmacological properties.
Renson
M
M
Université de Liège, Service de Chimie Organique, Belgique.
Dereu
N
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000975:Antioxidants / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology*; D054833:Isoindoles; D051379:Mice; D016566:Organoselenium Compounds; D012643:Selenium / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D012643:Selenium
Les benzisosélénazolinones et leurs dérivés, nouvelle série d'antiinflammatoires et d'antioxydants.