[Parathyroid hormone-related peptide (PTHrP)].
PTHrP, which causes humoral malignant hypercalcaemia in man and animals, acts on bone and kidney in a way similar to that of parathyroid hormone. PTHrP released by fetal parathyroid glands stimulates placental calcium transport in pregnant ewes and maintains the calcium gradient from the dam to its foetus. PTHrP, which is also present in the mammary gland, colostrum and milk, might play an important physiological role in regulating calcium secretion through milk and calcium metabolism in newborn animals.
Barlet
J P
JP
INRA Theix, Unité métabolisme minéral et ostéogénèse, St-Genès-Champanelle, France.
Davicco
M J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D044162:Parathyroid Hormone-Related Protein; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011506:Proteins / Q000737:chemistry / Q000502:physiology
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D002118:Calcium
Le peptide apparenté à l'hormone parathyroïdienne (PTHrP).