title: Premonitory symptoms in migraine without aura: a clinical investigation.
abstract: Thirty-three out of 100 patients affected by migraine without aura, reported premonitory symptoms in at least 50% of attacks and were considered to be affected by complete or premonitory common migraine. This group had a greater positive familiarity for migraine, a lower mean age of onset, and a higher average number of trigger factors compared with other patients. These three differences were statistically significant; hence we hypothesized that patients with migraine attacks generally preceded by premonitory symptoms have a stronger constitutional migraine trait with a premature weakening of their antinociceptive adaptation systems to the environment and to stressful events.
authors.affiliation: A Division of General Medicine, Hospital of Varese, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santoro
authors.forename: F
authors.initials: F
authors.lastname: Bernasconi
authors.forename: F
authors.initials: F
authors.lastname: Sessa
authors.forename: A
authors.initials: A
authors.lastname: Venco
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000503:physiopathology