[Synthesis and platelet aggregation inhibitory activity of 6-(4-substituted phenyl)-4,5-dihydro-3(2H)-pyridazinones].
To search for more ideal antithrombotic drugs sixteen 6-(4-substituted phenyl)-4,5-dihydro-3(2H)-pyridazinones were designed and synthesized. Some improvement of the synthetic method involved in constructing the piperazinyl group by cyclization of bisbromoethyl amine with 4-pyridazinonyl anilines. Preliminary pharmacological tests showed that all of the target compounds inhibited ADP induced platelet aggregation. Compounds II2, II3 and II4 were more potent than CCI-17810. The 5-methyl derivative of CCI-17810 (II4) was the most potent compound.
Jiang
Q
Q
Faculty of Pharmacy, Second Military Medical College, Shanghai.
Sun
C S
CS
D000818:Animals; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines