TMPHPG: a lipophilic derivative of EHPG for iron, gallium-68 and indium-111 hepatobiliary clearance.
TMPHPG (N,N'-trimethylenebis[2-(2-hydroxy-3,5-dimethylphenyl)glycine]) is a derivative of the ligand EHPG (ethylenebis[2-(o-hydroxyphenyl)glycine]) but is more lipophilic and had been synthesized to increase hepatobiliary clearance. 59Fe(III), 68Ga(III) and 111In(III) complexes of this ligand have been investigated as potential imaging agents for MRI, PET and SPECT, respectively. Metal-dependent differences in blood and liver clearance in mature rats have been evaluated.
Madsen
S L
SL
Edward Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, MO 63110.
Bannochie
C J
CJ
Welch
M J
MJ
Mathias
C J
CJ
Martell
A E
AE
D000818:Animals; D001646:Bile / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D005029:Ethylenediamines / Q000737:chemistry; D005260:Female; D005708:Gallium / Q000737:chemistry / Q000493:pharmacokinetics*; D005710:Gallium Radioisotopes; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D007204:Indium / Q000737:chemistry / Q000493:pharmacokinetics*; D007205:Indium Radioisotopes; D007501:Iron / Q000737:chemistry / Q000493:pharmacokinetics*; D007504:Iron Radioisotopes; D008099:Liver / Q000378:metabolism; D011877:Radionuclide Imaging / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014018:Tissue Distribution
D005029:Ethylenediamines; D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; D007504:Iron Radioisotopes; D007204:Indium; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); C069896:N,N'-trimethylenebis(2-(2-hydroxy-3,5-dimethylphenyl)glycine); D005708:Gallium; D007501:Iron; D005998:Glycine