Circadian variations in vigilance states in the alcohol-dependent rat.
Waking and sleep states were studied in the alcohol-dependent rat after administration of ethanol (416 mg/kg/hr) by indwelling intragastric catheter (IGC) for 13 days. Electropolygraphic recordings performed for a total of 24 hr from the start of withdrawal were compared with those of control rats receiving water by IGC and showed 1) that rapid eye movement sleep was the most sensitive of the four vigilance states studied. A decrease was noted both for the total duration of recording and for the light period; 2) that nonactive wakefulness was the only vigilance state to show an inversion of percentages between the light and dark period; 3) that the light period was the best time for studying changes in vigilance states. Changes included increased percentages of active and nonactive wakefulness and decreased percentages of slow-wave and rapid eye movement sleep. This was due to a change in the number of episodes rather to a change in their mean duration. No significant change occurred during the dark period.
Rouhani
S
S
Département de Physiologie Humaine UFR Biomédicale, Paris, France.
Emmanouilidis
E
E
Tran
G
G
Durlach
J
J
Payan
C
C
Fermanian
J
J
Manicom
R
R
Soulairac
A
A
Poenaru
S
S
D000430:Alcohol Withdrawal Delirium / Q000523:psychology*; D000437:Alcoholism / Q000523:psychology*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D000431:Ethanol / Q000493:pharmacokinetics; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012894:Sleep Stages / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D000431:Ethanol