Severe infantile colic and food intolerance: a long-term prospective study.
To determine the relationship between infantile colic and cow's milk protein intolerance (CMPI) in formula-fed infants, 70 infants (38 male, 32 female) were selected, with mean age 30.2 +/- 21.4 days, with severe colic (duration of crying greater than 4 h per day for 5 days per week). In 50 of the infants in the study group (71.4%) there was a remission of symptoms when cow's milk protein (CMP) was eliminated from the diet. Two successive challenges caused the return of symptoms in all these 50 infants. There was a positive anamnesis for atopy in 9 of 50 of the patients with CMP-related colic and in 1 of 20 of those with non-CMP-related colic (p greater than 0.05). A follow-up period of 18 months' mean duration showed that 22 of 50 (44%) of the infants with CMP-related colic and 1 of 20 (5%) of those with non-CMP-related colic developed an overt alimentary intolerance (p less than 0.02). We conclude that a considerable percentage of the infants with severe colic also have CMPI and that in these cases, dietetic treatment should be the first therapeutic approach.
Iacono
G
G
IV Divisione Lattanti, Ospedale G. Di Cristina, Universita' Di Palermo, Italy.
Carroccio
A
A
Montalto
G
G
Cavataio
F
F
Bragion
E
E
Lorello
D
D
Balsamo
V
V
Notarbartolo
A
A
D003085:Colic / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D007223:Infant; D007225:Infant Food / Q000009:adverse effects; D007231:Infant, Newborn; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications* / Q000178:diet therapy; D008894:Milk Proteins / Q000009:adverse effects*; D011446:Prospective Studies
D008894:Milk Proteins