title: Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil.
abstract: The metabolism of alpha-linolenic acid from canola oil was studied in eight normolipidemic men. The 42-day study was divided into three periods: a 6-day pre-experimental and two 18-day experimental. Approximately 75% of the dietary fat (28% of total energy) was provided by a mixture of fats during the pre-experimental period and either canola oil (CO) or sunflower oil (SO) during the experimental periods. The CO and SO diets were fed in a cross-over design. The ratios of linoleic to linolenic acid were 2.6:1 and 73.9:1 in the CO and SO diets, respectively. Dietary fat source had an effect on plasma phospholipid fatty acids: 18:1n-9, 18:3n-3 and 20:5n-3 were higher (p less than 0.05), and 18:2n-6 was lower in the phosphatidylcholine fraction; 18:1n-9 was higher and 20:4n-6 lower in the phosphatidyl-ethanolamine fraction; and 18:1n-9 and 20:5n-3 were higher and 20:4n-6 and 22:6n-3 were lower in the alkenylacyl ethanolamine phospholipid fraction on the CO diet as compared to the SO diet. Consumption of the canola oil diet resulted in higher n-3 fatty acid levels and lower n-6 fatty acid levels in plasma phospholipids than consumption of the sunflower oil diet.
authors.affiliation: Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Corner
authors.forename: V M
authors.initials: VM
authors.lastname: Bruce
authors.forename: B E
authors.initials: BE
authors.lastname: McDonald
mesh_terms: D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000097:blood; D008042:Linolenic Acids / Q000008:administration & dosage / Q000097:blood; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000097:blood; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D010938:Plant Oils / Q000494:pharmacology; D000074262:Rapeseed Oil; D000074242:Sunflower Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D010938:Plant Oils; D000074262:Rapeseed Oil; D000074242:Sunflower Oil; D019301:Oleic Acid; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid