Genetic polymorphism of rat liver gangliosides.
Liver ganglioside patterns of eight rat strains were classified according to two phenotypes: SHR type, characterized by predominance of b-series gangliosides (GD1b, GT1b, GQ1b), and DA type, characterized by predominance of a-series gangliosides (GM1, GD1a). Comparison of ganglioside pattern expressed in the liver of F1 hybrids and backcross F2 hybrids indicated that SHR type is controlled by a single autosomal-dominant gene which probably determines the expression of sialytransferase 2 activity for synthesis of GD3 from GM3.
Bouhours
D
D
Institut National de la Santé et de la Recherche Medicale, Unité 76, Paris, France.
Bouhours
J F
JF
D000818:Animals; D002240:Carbohydrate Sequence; D005732:Gangliosides / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D006056:Golgi Apparatus / Q000201:enzymology; D008099:Liver / Q000502:physiology*; D008969:Molecular Sequence Data; D010641:Phenotype; D011110:Polymorphism, Genetic; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012799:Sialyltransferases / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment
D005732:Gangliosides; D012799:Sialyltransferases