Phenoxybenzamine reduces mortality associated with intracerebral injections of excitatory neurotoxins.
Intracerebral injections of kainic acid produce gross hematuria, renal cortical necrosis, and an associated high mortality. Hematuria is virtually eliminated and mortality significantly reduced by pretreatment with phenoxybenzamine.
Vanderwolf
C H
CH
Department of Psychology, University of Western Ontario, London, Canada.
Cooley
R K
RK
D000818:Animals; D004027:Diencephalon; D006417:Hematuria / Q000401:mortality / Q000517:prevention & control*; D007267:Injections; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D007672:Kidney Cortex / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D009498:Neurotoxins / Q000037:antagonists & inhibitors*; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D013687:Telencephalon
D009498:Neurotoxins; D010643:Phenoxybenzamine; D007608:Kainic Acid