Duplicate leader exons in the mouse liver-type alkaline phosphatase gene.
A mouse genomic region corresponding to that containing the E2 exon of the rat liver alkaline phosphatase gene was isolated and characterized. A sequence comparison of these two regions showed homology of about 85% and complete conservation of sequence stretchs around the splicing-donor site. This sequence was proved to be transcribed in the mouse liver as poly(A)+RNA. These data suggest that, together with the E1-type transcript, the mouse liver-type alkaline phosphatase gene is provided with at least two alternative leader exons.
Toh
Y
Y
Department of Biochemistry, Kyushu University, Fukuoka, Japan.
Yamamoto
M
M
Endo
H
H
Misumi
Y
Y
Ikehara
Y
Y
D000469:Alkaline Phosphatase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D005091:Exons; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012326:RNA Splicing; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
D012333:RNA, Messenger; D000469:Alkaline Phosphatase