[Structure of the neointima after balloon catheter injury of the rabbit aorta in the context of hypercholesterolemia: analysis of endothelial influence on lipid accumulation].
Balloon catheter de-endothelialization of abdominal aorta of cholesterol-fed rabbits was performed. As a result, partly endothelialized neointima was formed, consisting of smooth muscle cells and macrophages. Neutral lipids stored more intensely in non-endothelialized part of neointima. Preferential intracellular lipid accumulation in this area was observed while predominantly extracellular lipid accumulation was found in endothelium-covered part of neointima. It is supposed that endothelium inhibits intracellular lipid accumulation and at the same time stimulates an extracellular one, but as a whole it reduces the density of lipid inclusions in neointima.
Rekhter
M D
MD
Andrianova
I V
IV
Ragimov
S E
SE
Andreeva
E R
ER
Mironov
A A
AA
Tararak
E M
EM
Orekhov
A N
AN
D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries / Q000378:metabolism / Q000473:pathology*; D002404:Catheterization; D004730:Endothelium, Vascular / Q000502:physiology*; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism; D008264:Macrophages / Q000473:pathology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011817:Rabbits
Struktura neointimy aorty krolika posle povrezhdeniia ballonnym kateterom na fone giperkholesterinemii: analiz vliianiia éndoteliia na nakoplenie lipidov.