Chronic clomipramine increases firing rate in lateral septal nuclei of the rat.
A single dosage of several antidepressants produces an increased rate of firing in lateral septal nuclei of the rat. The objective of the present study was to clarify the long-term treatment action of clomipramine on the septal nuclei of the rat. A progressive increase of firing rate appeared after long-term treatment with clomipramine (1.25 mg/kg, IP; twice a day, for 25 days). The most noticeable firing increase occurred in the lateral septal nuclei, which primarily receive serotonergic innervation. Irregular changes occurred in the corpus callosum and cingulum. Finally, in other poorly innervated serotonergic septal regions, the treatment lacked effects. This suggested that the action of clomipramine was primarily due to interaction with the serotonergic system.
Contreras
C M
CM
Depto. de Fisiología, Universidad Nacional Autónoma de México, México.
Marván
M L
ML
Alcalá-Herrera
V
V
Guzmán-Sáenz
M A
MA
D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D003337:Corpus Callosum / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000033:anatomy & histology / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology; D013238:Stereotaxic Techniques
D012701:Serotonin; D002997:Clomipramine