Application of volume-selected, two-dimensional multiple-quantum editing in vivo to observe cerebral metabolites.
The volume selection technique SPACE has been combined with a two-dimensional multiple-quantum editing sequence to uniquely detect certain J-coupled cerebral metabolites. In vivo results demonstrating edited glutamate/glutamine and lactate from 0.4 ml of a rat's brain at 4.7 T are presented. The sequence was optimized to balance multiple-quantum generation and signal loss due to T2 relaxation. Without due regard to T2 relaxation little signal is observed.
Crozier
S
S
Department of Chemistry, University of Queensland, St. Lucia, Australia.
Brereton
I M
IM
Rose
S E
SE
Field
J
J
Shannon
G F
GF
Doddrell
D M
DM
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051381:Rats