title: Ovulation-inducing activity of luliberin (LHRH) complexed by copper(II), nickel(II), and zinc(II) ions.
abstract: We have shown that the complexation of luteinizing hormone releasing hormone, luliberin (LHRH), a hypothalamic neurohormone, by Cu(II), Ni(II), and Zn(II) may affect its basic, ovulation-inducing potency in the dose responsive manner. Some explanation of the obtained results are offered here.
authors.affiliation: Institute of Chemistry, University of Wroclaw, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Kozlowski
authors.forename: E
authors.initials: E
authors.lastname: Masiukiewicz
authors.forename: E
authors.initials: E
authors.lastname: Potargowicz
authors.forename: B
authors.initials: B
authors.lastname: Rzeszotarska
authors.forename: A
authors.initials: A
authors.lastname: Walczewska-Sumorok
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003300:Copper; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008969:Molecular Sequence Data; D009532:Nickel; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D051381:Rats; D011915:Rats, Inbred BUF; D011919:Rats, Inbred Strains; D015032:Zinc
chemical_list: D007987:Gonadotropin-Releasing Hormone; D003300:Copper; D009532:Nickel; D015032:Zinc