title: Induction of the Citrobacter freundii group I beta-lactamase in Escherichia coli is not dependent on entry of beta-lactam into the cytoplasm.
abstract: Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm is not necessary for induction of ampC.
authors.affiliation: Department of Microbiology, School of Medical Sciences, University of Bristol, United Kingdom.
authors.forename: M J
authors.initials: MJ
authors.lastname: Everett
authors.forename: I
authors.initials: I
authors.lastname: Chopra
authors.forename: P M
authors.initials: PM
authors.lastname: Bennett
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D002954:Citrobacter / Q000201:enzymology* / Q000235:genetics; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology*; D010405:Penicillinase / Q000096:biosynthesis* / Q000235:genetics; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D010405:Penicillinase