title: Clinical value of PET with 18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury.
abstract: We studied 15 patients clinically suspected to have recurrent brain tumor or radiation injury, using positron emission tomography (PET) with 18F-fluorodeoxyglucose (18FDG) and L-methyl-11C-methionine (11C-Met). PET with 11C-Met (Met-PET) clearly delineated the extent of recurrent brain tumor as focal areas of increased accumulation of 11C-Met, and was useful for early detection of recurrent brain tumor. PET with 18FDG (FDG-PET) showed focal 18FDG-hypermetabolism in one patient with malignant transformation of low grade glioma, and demonstrated its usefulness for evaluation of malignant transformation. 18FDG-hypometabolism was observed in all patients with radiation injury, but was also found in one patient with recurrent malignant brain tumor. 11C-Met uptake in 3 patients with radiation injury was similar to that of the normal cortical tissue. FDG-PET can be used to initially exclude recurrent brain tumor which is seen as 18FDG-hypermetabolism. The combined use of Met-PET in addition to FDG-PET can improve the accuracy of differentiation of recurrent brain tumor with 18FDG-hypometabolism from radiation injury.
authors.affiliation: Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: I
authors.initials: I
authors.lastname: Kanno
authors.forename: F
authors.initials: F
authors.lastname: Shishido
authors.forename: A
authors.initials: A
authors.lastname: Inugami
authors.forename: S
authors.initials: S
authors.lastname: Higano
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: N
authors.initials: N
authors.lastname: Yasui
authors.forename: K
authors.initials: K
authors.lastname: Mineura
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000528:radiation effects; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D014055:Tomography, Emission-Computed; D014814:Vitamin U
chemical_list: D019788:Fluorodeoxyglucose F18; D014814:Vitamin U; D003847:Deoxyglucose; D008715:Methionine; C038344:methionine methyl ester