Beta-endorphin's modulation of lymphocyte proliferation is dose, donor, and time dependent.
We find that beta-endorphin (Bend) can have, positive, negative, or neutral dose-dependent effects on the mitogen-stimulated proliferation of human peripheral blood lymphocytes. The distribution of positive, negative, or neutral responses was nonrandom. In studies carried out over a year, we show that an individual's mitogen-stimulated lymphocyte proliferative response to Bend can change with time. We show that the inhibition induced by cortisol can be, in part, relieved by Bend. On the basis of our results and those of others in the field, we put forward a model that can qualitatively account for many of the observations we and other investigators have made.
Millar
D B
DB
Laboratory of Biochemical Genetics, National Institute of Mental Health Neuroscience Center at St. Elizabeths, Washington, D.C. 20032.
Hough
C J
CJ
Mazorow
D L
DL
Gootenberg
J E
JE
D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015213:Neuroimmunomodulation / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors; D001615:beta-Endorphin / Q000494:pharmacology*
D010835:Phytohemagglutinins; D001615:beta-Endorphin; D006854:Hydrocortisone