[Extrapyramidal side effects of 2 different formulations of fluphenazine chloride injections].
Comparison of extrapyramidal side effects of two fluphenazine hydrochloride injections. Lyogen and Moditen was carried out by the in vivo experiments in mice. The incidence, intensity and duration of the catalepsy in mice after i. m. application of 10 mg/kg fluphenazine hydrochloride in two forms of sterile water solution have been observed. Catalepsy of significant intensity occurred after a short period of 15 minutes regarding the both formulations and maximal values were observed 30 and 60 minutes after application of Lyogen, and Moditen respectively. Significant values of cataleptic intensity with respect to control group (the water for injection-treated group) were registered during 28 hours after the application of both formulations. This study of cataleptic effects could not confirm significant differences between these two formulations, between the rate of occurrence and duration of effects. On the other hand, the difference between intensities were observed and were more prominent in the period between 6-24 hours. An the most cases they were not significant (p greater than 0.05).
Milić-Askrabić
J
J
Farmaceutski fakultet Sarajevo.
Hadzović
S
S
Samardzić
Z
Z
D000818:Animals; D005476:Fluphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007267:Injections; D008297:Male; D051379:Mice
C011825:fluphenazine depot; D005476:Fluphenazine
Ekstrapiramidalni sporedni efekti dviju razlicitih formulacija flufenazin-hlorid injekcija.