title: Multinucleation of macrophages with water-solubilized lignin derivatives in vitro.
abstract: When macrophages derived from bone marrow were incubated with lignin derivative at 10 micrograms/ml, they formed multinucleated giant cells containing more than sixty nuclei. Cine-microscopic observation revealed that the formation of the giant cells was due to cell fusion. This phenomenon was specific for primary-cultured macrophages, and was not observed with either a macrophage cell line or established cell lines derived from other tissues.
authors.affiliation: Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sorimachi
authors.forename: K
authors.initials: K
authors.lastname: Akimoto
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: A
authors.initials: A
authors.lastname: Niwa
authors.forename: S
authors.initials: S
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Yasumura
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells; D002459:Cell Fusion / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002478:Cells, Cultured; D015726:Giant Cells / Q000187:drug effects* / Q000648:ultrastructure; D008031:Lignin / Q000494:pharmacology*; D051381:Rats
chemical_list: D008031:Lignin