title: Monocyte/macrophage infiltrate in 41 oligodendrogliomas. Paraffin-wax study.
abstract: We have studied wax-embedded tissue from 41 (33 low and 8 high grade) oligodendrogliomas with KP 1, a new monoclonal anti-monocytes/macrophages (M/Ms) antibody. Away from areas of degeneration, M/Ms cells were detected in 63% of low grade and 87% of high grade tumours. The latter had, on average, at least more than twice as many infiltrating M/Ms. It is concluded that our findings may indicate the presence of a host M/Ms immune response and that KP 1 antibody is suitable for the study of such infiltrate, thus lessening (but not obviating) the need for frozen tissue for immunohistological studies.
authors.affiliation: Department of Neuropathology, Midland Centre for Neurosurgery and Neurology, Birmingham, Great Britain.
authors.forename: M L
authors.initials: ML
authors.lastname: Rossi
authors.forename: J
authors.initials: J
authors.lastname: Buller
authors.forename: S A
authors.initials: SA
authors.lastname: Heath
authors.forename: H B
authors.initials: HB
authors.lastname: Coakham
mesh_terms: D000906:Antibodies; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D009000:Monocytes / Q000473:pathology*; D009837:Oligodendroglioma / Q000276:immunology / Q000473:pathology*; D010232:Paraffin; D012189:Retrospective Studies
chemical_list: D000906:Antibodies; D010232:Paraffin