title: Convulsive disorders: status epilepticus.
abstract: Status epilepticus (SE) remains one of the most serious disorders affecting the central nervous system. Recent progress in understanding the mechanisms of the brain damage produced by SE make even more apparent the need to quickly terminate this condition, prevent its recurrence, and treat its complications. Intracellular calcium concentrations rise, prompting a cascade of excitotoxic consequences. Therapy for SE currently consists of agents which stop seizures (benzodiazepines, phenytoin, barbiturates). This review discusses their use in SE.
authors.affiliation: Department of Neurology, University of Virginia School of Medicine, Charlottesville.
authors.forename: T P
authors.initials: TP
authors.lastname: Bleck
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001927:Brain Diseases / Q000209:etiology; D006801:Humans; D013226:Status Epilepticus / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants