Circadian variation of cardiac performance in coronary heart disease.
To study the circadian variation of cardiac performance in patients with coronary heart disease, three exercise tests on a bicycle ergometer were performed during the active part of the day (10 a.m., 2 p.m. and 6 p.m.), recording ST-segment depression and pulmonary capillary wedge pressure. Ten male patients with angiographically documented coronary heart disease underwent bicycle ergometry during placebo and during nitrate therapy (placebo controlled, double-blind crossover 2 x 20 mg IS-5-MN and 1 x 120 mg ISDN sustained release). During placebo as well as during nitrate therapy there was a gradual decrease of cardiac performance during the day, documented by the increase in ST-depression and pulmonary capillary wedge pressure at equal work loads. High nitrate concns led to a significant reduction of both ST-depression and preload with a marked circadian-phase dependency of cardiovascular effects.
Wortmann
A
A
Medical Clinic II, University Erlangen-Nuernberg, F.R.G.
Bachmann
K
K
D000368:Aged; D002940:Circadian Rhythm / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004562:Electrocardiography; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000502:physiology
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate