title: Levamisole treatment of oligospermia.
abstract: On the basis of elevated levels of seminal plasma immunoglobulins and a decreased production of LMI in the presence of PPD, 6 patients (out of the idiopathic normogonadotrophic oligospermic group) were selected for a therapeutic trial with levamisole. The following regime of treatment was applied: 3 days on levamisole (150 mg per day) followed by a 10 day interval without treatment, for a period of three months. The sperm count increased in 5 out of 6 patients and motility increased in 2. At the same time a reduction in seminal plasma IgG levels was observed in all treated patients. A significant increase of EA rosettes was observed after treatment.
authors.affiliation: Endocrinology Department and Laboratory for Immunology, Zvezdara Medical Centre, Beograd.
authors.forename: M I
authors.initials: MI
authors.lastname: Würzburger
authors.forename: G M
authors.initials: GM
authors.lastname: Prelević
authors.forename: S D
authors.initials: SD
authors.lastname: Brkić
authors.forename: S
authors.initials: S
authors.lastname: Vucković
authors.forename: N
authors.initials: N
authors.lastname: Despotović
authors.forename: V
authors.initials: V
authors.lastname: Milović
mesh_terms: D002464:Cell Migration Inhibition; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007978:Levamisole / Q000627:therapeutic use*; D016131:Lymphocyte Subsets; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D007978:Levamisole