Calcium channel blockers and gingival overgrowth.
Calcium channel blockers are widely used in medical practice for the management of cardiovascular disorders. Of concern to the dental practitioner is the effect of these drugs on the gingival tissues. All classes of calcium channel blockers have been implicated in causing gingival overgrowth. This review considers the prevalence, clinical features, histopathology, pathogenesis and management of this unwanted side-effect.
Seymour
R A
RA
Department of Operative Dentistry, Dental School, Newcastle upon Tyne.
D002121:Calcium Channel Blockers / Q000009:adverse effects*; D003524:Cyclosporins / Q000009:adverse effects; D004110:Diltiazem / Q000009:adverse effects; D005347:Fibroblasts / Q000187:drug effects; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D006801:Humans; D009543:Nifedipine / Q000009:adverse effects; D014664:Vasodilation; D014700:Verapamil / Q000009:adverse effects
D002121:Calcium Channel Blockers; D003524:Cyclosporins; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine