[HLA and sprue: a study of Sicilian families with celiac disease].
The authors have studied the HLA genotypes in 17 Sicilian coeliac children, in their parents and in their healthy brothers. A positive association has been found between coeliac disease (C.D.) and HLA antigens; this was strongest firstly for DQW2 and than for DR7 and DR3. Those antigens however do not result specific for C.D., because they were present in healty-control population too and because one coeliac patient was DQW2, DR7 and DR3 negative. A distortion of vertical transmission of HLA haplotypes has been observed in the studied patients, and this occurred for DR3/DQW2 that was transmitted mainly by paternal way. Moreover, in the healty brothers of our coeliac subjects a significant reduction of HLA antigens DQW2, DR7 and DR3 has not been found. Those observation and the finding that in our families the responsible gene for C.D. seems to have a low penetrance, should induce to search others genetic markers for coeliac disease.
Cataldo
F
F
Clinica Pediatrica R, P.O. Aiuto Materno, Palermo, Italia.
Caruso
C
C
Maltese
I
I
Lio
D
D
Marino
V
V
Albeggiani
A
A
D000293:Adolescent; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male
D005819:Genetic Markers; D006680:HLA Antigens
HLA e celiachia: studio su alcune famiglie siciliane con malattia celiaca.