title: [Incidence of mandibular osteoradionecrosis in a series of 13 cases of carcinoma of the mouth floor].
abstract: In a 13-case series of epithelioma of the floor of the mouth given cobalt-therapy irrespective of the selected therapeutic protocol, the authors recorded 5 cases of osteoradionecrosis. In this study, they review both risk and prevention factors linked with radionecrosis at the localization site of this particular type of tumor. They also stress the importance of adapting the treatments, when introducing so-called néo-adjuvant systemic chemotherapy, the high efficacy rate of which is likely to reduce the risks of radionecrosis. This can be achieved either by eliminating completely or limiting the surgical step, or by bringing modifications to the post-operative radiation regimen.
authors.affiliation: Service ORL, Hôpital Broussais, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Bouttier
authors.forename: P
authors.initials: P
authors.lastname: Perreau
authors.forename: J P
authors.initials: JP
authors.lastname: Bataini
authors.forename: J E
authors.initials: JE
authors.lastname: Demaldent
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008336:Mandibular Diseases / Q000209:etiology; D008875:Middle Aged; D009060:Mouth Floor; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000628:therapy; D010025:Osteoradionecrosis / Q000209:etiology; D012307:Risk Factors
vernacular_title: Incidence des ostéo-radio-nécroses mandibulaires sur une série de 13 cas de carcinomes du plancher buccal.