title: Abolition of optokinetic afternystagmus by aminoglycoside ototoxicity.
abstract: We studied optokinetic afternystagmus in eight subjects with loss of or impairment of vestibular function due to ototoxic antibiotics. We found that the initial amplitude, the time constant, and the slow-phase cumulative eye position of optokinetic afternystagmus were significantly reduced in the patients. Slow-phase cumulative eye position most reliably distinguished our patients' responses from those of a normal group.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: T C
authors.initials: TC
authors.lastname: Hain
authors.forename: D S
authors.initials: DS
authors.lastname: Zee
mesh_terms: D000328:Adult; D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009760:Nystagmus, Physiologic / Q000187:drug effects*; D015837:Vestibular Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents