Disease mechanisms in venous ulceration.
Disease mechanisms in venous ulceration are poorly understood. Recent hypotheses have postulated two separate mechanisms to explain the extensive microcirculatory damage which leads, eventually, to ulceration. A number of treatments, based on the suggested pathogenesis, have been undertaken and this review critically examines these theories in the light of the results of these treatments.
Sarin
S
S
Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London.
Cheatle
T R
TR
Smith
P D
PD
Scurr
J H
JH
D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D014652:Vascular Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D014655:Vascular Resistance