The effect of a progesterone-induced immunologic blocking factor on NK-mediated resorption.
Transfer of spleen cells from poly (I)-poly(C12U)-treated Balb/c mice to 6.5-days-pregnant Balb/c mice significantly increased the resorption rate (P less than 0.01) from 11% to 48%. The supernatant of progesterone-treated spleen cells from pregnant C3H mice abrogated the effect of spleen cell transfer. We conclude that by blocking NK activity in vivo, the progesterone-induced blocking factor favors the maintenance of pregnancy.
Szekeres-Bartho
J
J
Institute of Microbiology, University Medical School, Pècs, Hungary.
Kinsky
R
R
Chaouat
G
G
D000818:Animals; D000951:Antigens, Neoplasm / Q000502:physiology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000517:prevention & control*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011070:Poly I-C; D011072:Poly U; D011131:Polyribonucleotides; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D011374:Progesterone / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D000951:Antigens, Neoplasm; D011131:Polyribonucleotides; C020163:blocking factor; D011072:Poly U; D011374:Progesterone; C047490:poly(I).poly(c12,U); D011070:Poly I-C