[Quantitative changes in the total proteins of the cells of the hypothalamic supraoptic nucleus after extreme exposures: acute immobilization and deprivation of the paradoxical sleep phase].
It has been shown that 1-hour acute immobilization of rats resulted in a decrease of total protein content (per 1 cell) in neurones (by 17% in cytoplasm and 22% in nucleus) of the supraoptic nucleus of the hypothalamus and in their glial satellite cells (by 10%), mainly at the expense of the nuclei of the latter. These changes remained at the same level in the neuronal cytoplasm and satellite cells within 6 hours after cessation of acute immobilization, being abolished in the neuronal nuclei. Deprivation of REM sleep for 24 hours affected these parameters to the same extent as acute immobilization. However, 6-hour rest was sufficient for normalisation in satellite cells and for decrease in protein deficiency in the neuronal nuclei; yet protein deficiency still sustained in the neuronal cytoplasm. REM sleep deprivation was also accompanied by a decrease in tritium incorporation into satellite cell proteins (by 18%); after 3-hour rest, incorporation of the label into satellite cells was restored to the initial level being increased by 20% in neuronal nuclei; another 3-hour rest resulted in normalisation of labeling in the neuronal nuclei and in 27% increase of labeling in the satellite cells.
Glushchenko
T S
TS
Malinauskaĭte
L O
LO
Klenikova
V A
VA
Demin
N N
NN
D000208:Acute Disease; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009457:Neuroglia / Q000737:chemistry; D009474:Neurons / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013495:Supraoptic Nucleus / Q000737:chemistry*; D013997:Time Factors
D009419:Nerve Tissue Proteins
Kolichestvennye izmeneniia summarnykh belkov kletok supraopticheskogo iadra gipotalamusa posle ékstremal'nykh vozdeĭstviĭ: ostraia immobilizatsiia, lishenie paradoksal'noĭ fazy sna.