[Norepinephrine-induced heart failure and the protective effect of taurine].
The prolonged noradrenaline treatment of rats (total dosage from 1 week--25 mg/kg), results in greatly reduced cardiac pump function and heart rate with a pronounced increase in left ventricular diastolic stiffness. These functional changes are associated with a deficiency of energy supply, especially depletion of phosphocreatine content. The taurine administration (100 mg/kg prior to 20 min noradrenaline injection) is accompanied by reliably less essential cardiac insufficiency. Moreover, the ATP, ADP level is normal and phosphocreatine content enhances by 15%.
Popovich
M I
MI
Kobets
V A
VA
Kapel'ko
V I
VI
D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006333:Heart Failure / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000008:administration & dosage*; D013997:Time Factors
D013654:Taurine; D009638:Norepinephrine
Porazhenie serdtsa, vyzyvaemoe noradrenalinom, i zashchitnyĭ éffekt taurina.