Vasodilatory effects of lidocaine on epicardial porcine coronary arteries.
To investigate the mechanism of lidocaine's effect to cause vasorelaxation, swine epicardial mid-right coronary arterial rings were placed under constant (5 g) tension in a muscle bath, precontracted with 35 mmol/l KCl and exposed to increasing concentrations of lidocaine (3-2,000 micrograms/ml). At a concentration of 10 micrograms/ml, mild vasoconstriction occurred, increasing tension 1.9 +/- 0.1% above baseline. Vasodilation began to occur at 30 micrograms/ml and was maximal at 2,000 micrograms/ml, reducing tension 97.5 +/- 0.2% below baseline. Vasodilation was not altered significantly by removal of endothelium or by pretreatment with propranolol or indometacin.
Perlmutter
N S
NS
Department of Medicine, Oregon Health Sciences University, Portland.
Wilson
R A
RA
Edgar
S W
SW
Sanders
W
W
Greenberg
B H
BH
Tanz
R
R
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013552:Swine; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D011189:Potassium Chloride; D008012:Lidocaine; D011433:Propranolol; D007213:Indomethacin