Inhibition of posterior capsule opacification by 5-fluorouracil in rabbits.
An extracapsular cataract extraction was performed on both eyes of 24 rabbits. Irrigation for 10 min of the capsular bag of the left (test) eye with 8-12 cm3 of 1 litre of BSS-plus to which had been added 50 mg of 5-fluorouracil significantly inhibited proliferation of the anterior capsular epithelium as compared with the right (control) eyes identically treated except for the omission of 5-fluorouracil (p less than 0.001). Corneal endothelial counts did not differ significantly. A reduction in opacification of the posterior capsule is expected from 5-fluorouracil treatment.
Ruíz
J M
JM
División de Oftalmología, Facultad de Medicina, Universidad de Alicante, España.
Medrano
M
M
Alió
J L
JL
D000818:Animals; D002386:Cataract / Q000517:prevention & control*; D002387:Cataract Extraction; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004728:Endothelium, Corneal / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity; D007903:Lens Capsule, Crystalline / Q000187:drug effects*; D011817:Rabbits
D005472:Fluorouracil