Lack of effect of granulocyte-macrophage colony stimulating factor on the rat aorta or human saphenous vein.
1. In order to assess whether the observed hypotensive response in some patients given human granulocyte-macrophage colony stimulating factor (GM-CSF) is caused by a direct vascular effect of the GM-CSF, the effects of mouse and human GM-CSF were examined in rat aortic rings and human saphenous veins respectively. 2. No effects of GM-CSF were observed, either in the presence or absence of endothelium, on responses to the alpha-adrenoceptor agonist phenylephrine. 3. These data suggest that GM-CSF does not have direct effects on either vascular endothelium or smooth muscle, and that a direct vascular effect of GM-CSF is not the explanation for the observed clinical response.
Watabe
T
T
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Moulds
R F
RF
D000818:Animals; D001011:Aorta / Q000187:drug effects; D004730:Endothelium, Vascular / Q000503:physiopathology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012501:Saphenous Vein / Q000187:drug effects
D016178:Granulocyte-Macrophage Colony-Stimulating Factor