title: Elevated serum levels of creatine kinase BB in autosomal dominant osteopetrosis type II.
abstract: Serum levels of creatine kinase isoenzyme BB (CK-BB) were measured spectrophotometrically and by electrophoresis in 17 patients with autosomal dominant osteopetrosis (ADO) and compared with those of age- and sex-matched controls. Eight patients had ADO type 1 and nine patients had ADO type II. CK-BB was significantly increased (p less than 0.002) in type II but normal in type I compared with controls. This finding supports heterogeneity of ADO, and it may indicate a potential role for CK-BB as a marker of immature osteoclasts.
authors.affiliation: Department of Medical Endocrinology, Odense University Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Gram
authors.forename: S
authors.initials: S
authors.lastname: Antonsen
authors.forename: M
authors.initials: M
authors.lastname: Hørder
authors.forename: J
authors.initials: J
authors.lastname: Bollerslev
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood* / Q000235:genetics; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D010022:Osteopetrosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000235:genetics; D011859:Radiography
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase