Blood cell kinetics after a 385 cGy total body irradiation given to a CML patient for bone marrow transplantation.
Fractionated total body irradiation was given to a patient with chronic myeloid leukemia as part of a conditioning regimen for bone marrow transplantation. The radiation treatment was discontinued after the third fraction (total dose: 385 cGy) and no bone marrow graft was given because of the patient's refusal. Peripheral blood lymphocyte levels were monitored for 3 months and lymphocyte subsets up to 50 days post-irradiation. Lymphocyte numbers reached the nadir 48 h after the last fraction and lymphopenia was still present 3 months later. All lymphocyte subsets (T, B, CD4 and CD8 cells) showed a similar decrease except for natural killer cells which exhibited a larger decline. The regenerative capacity of T cells, CD4 subset and natural killer cells was less than that of B cells and CD8 lymphocyte subsets.
Girinsky
T
T
Department of Radiation Therapy, Gustave-Roussy Institute, Villejuif, France.
Baume
D
D
Socié
G
G
Pico
J L
JL
Malaise
E
E
Cosset
J M
JM
D000328:Adult; D001772:Blood Cell Count / Q000528:radiation effects*; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D007700:Kinetics; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000503:physiopathology; D016131:Lymphocyte Subsets / Q000528:radiation effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects*