Feasibility of measuring first pass extraction and flow with rubidium-82 in the kidneys.
A feasibility study has been carried out to evaluate rubidium-82, a potassium analog and generator-produced positron emitter, for measuring renal blood flow using a first pass model. Seven acute dogs were studied with beta probes and positron emission tomography to understand the dynamics of rubidium-82 in the kidneys. Preliminary results show that first pass extraction fraction for rubidium-82 ranged from 80-95% with an average of 89%. During the 150 sec of data collection, approximately 44.5% of the injected dose is excreted in the venous side and 9.75% in the ureter. Flow measurements with rubidium-82 and microspheres correlated well with the average control flow of 5.0 ml/min/gm measured by microspheres and 4.5 ml/min/gm of flow measured by rubidium-82 using the first pass model.
Mullani
N A
NA
Division of Cardiology, University of Texas Medical School, Houston 77225.
Ekas
R D
RD
Marani
S
S
Kim
E E
EE
Gould
K L
KL
D000818:Animals; D004285:Dogs; D005240:Feasibility Studies; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D012079:Renal Circulation / Q000502:physiology*; D012414:Rubidium Radioisotopes; D014055:Tomography, Emission-Computed
D012414:Rubidium Radioisotopes