title: [Study of the DNA-damaging activity of the mutagenic derivative of tetrahydrodiazapyrene, DDDTDP].
abstract: 2,7-diamino-4,9-dioxo-5,10-dioxy-4,5,9,10-tetrahydro-4.9--diaza prein (DDDTDP)--the frameshift mutagen--induced frameshift mutations in indicator strain Salmonella typhimurium. The mutagen displays strong DNA damaging activity in murine L cell line. The DNA was analyzed for single strand breaks by alkaline elution assay. Analysis of reparation of DNA breaks suggests that DDDTDP acts as bifunctional agent.
authors.forename: S K
authors.initials: SK
authors.lastname: Abilev
authors.forename: M M
authors.initials: MM
authors.lastname: Abdrazakov
mesh_terms: D002478:Cells, Cultured; D003432:Cross-Linking Reagents; D004249:DNA Damage; D016368:Frameshift Mutation; D009153:Mutagens; D011721:Pyrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: C018644:2,7-diamino-4,9-dihydroxy-5,10-dioxo-4,5,9,10-tetrahydro-4,9-diazapyrene; D003432:Cross-Linking Reagents; D009153:Mutagens; D011721:Pyrenes
vernacular_title: Izuchenie DNK-povrezhdaiushcheĭ aktivnosti mutagennogo proizvodnogo tetragidrodiazapirene DDDTDP.