Insulin--binding antibodies in Nigerian diabetic patients.
The levels of insulin antibodies were determined in 68 diabetic patients on insulin treatment and 30 normal subjects. Fifty (73.5%) of the patients had low levels of insulin antibodies (less than 20%), twelve (17.7%) had moderate levels (between 20 and 40%) while the remaining six (8.8%) had high antibody levels (greater than 40%). There was poor correlation of insulin antibody level with insulin dose (r = 0.16, p less than 0.1) and with duration of disease (r = 0.19, p less than 0.5). Where high levels of antibodies were detected the problems encountered in treating the patients with highly purified insulin preparations are discussed.
Bella
A F
AF
Department of Medicine, University College Hospital, Ibadan.
Adetuyibi
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A
D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006785:Hospitals, University; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000032:analysis* / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology; D009549:Nigeria; D010044:Outpatient Clinics, Hospital
D007328:Insulin; D007330:Insulin Antibodies