Is autoimmunity good for you? The Molecular Basis of Recognition in the Immune System sponsored by the European Federation of Immunological Societies, Edinburgh, UK, September 10-12, 1990.
In summary, the EFIS meeting highlighted key advances in the development of B and T cells and in the regulation of that development by other components of the immune system. Several of these recent advances were made possible by the use of transgenic mice expressing either a single antigen-specific receptor or an engineered form of that receptor. We can expect further advances as such mice are used to probe the development of immune responses to antigen. The large number of responding cells should allow heretofore difficult analyses of the cell interactions, immune cell localizations, and patterns of response during the generation of the primary immune response and should also facilitate the study of immune memory.
Swain
S L
SL
Department of Biology, University of California, San Diego, La Jolla 92093-0063.
Dutton
R W
RW
D000818:Animals; D000941:Antigens / Q000378:metabolism; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D007109:Immunity / Q000502:physiology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D008222:Lymphokines