title: N3-arylspiroimidazolidine-2,4-diones N3-arylspiroimidazolidine-2-thio-4-ones and 4-hydroxy derivatives. Synthesis and anthelmintic activity.
abstract: The synthesis of new N3-arylciclohexanespiroimidazolidine-2,4-diones, N3-arylciclohexanespiroimidazolidine-2-tio-4-ones and the 4-hydroxy derivatives is described and their structures discussed on the basis of I.R. and 1H-N.R.M. data. The anthelmintic activity of these compounds was tested.
authors.affiliation: Dpto. de Quimica Orgánica y Farmacéuticia, Facultad de Farmacia, Universidad Complutense, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Espada
authors.forename: C
authors.initials: C
authors.lastname: Pedregal
authors.forename: A
authors.initials: A
authors.lastname: Alonso
authors.forename: C
authors.initials: C
authors.lastname: López
authors.forename: L
authors.initials: L
authors.lastname: Salazar
authors.forename: M M
authors.initials: MM
authors.lastname: Martinez
authors.forename: J L
authors.initials: JL
authors.lastname: Guillén
authors.forename: A R
authors.initials: AR
authors.lastname: Martinez
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D004757:Enterobius / Q000187:drug effects; D006369:Heligmosomatoidea / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010124:Oxyuroidea / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000871:Anthelmintics; D007093:Imidazoles; D013141:Spiro Compounds; D013871:Thiones