Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients.
According to our supposition that "humoral mechanism" plays an important role in the pathogenesis of portal hypertension due to cirrhosis, antagonists to some of humoral substances would lower the portal pressure in cirrhotic patients. Wedged hepatic venous pressure (WHVP) was used as an indicator for changes of portal pressure. Cimetidine was given intravenously to 8 cirrhotic patients, in whom an average lowering of 0.72 kPa (7.3 cm H2O) of WHVP was observed subsequently. This change was of clinical significance as compared with the previous results of splenorenal shunting operations.
Leng
X S
XS
Department of Surgery, People's Hospital, Beijing Medical University.
Huang
C T
CT
Wang
X G
XG
Wang
X H
XH
Du
R Y
RY
D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D014690:Venous Pressure / Q000187:drug effects
D002927:Cimetidine