title: Pseudosemiglabrin, a platelet aggregation inhibitor from tephrosia semiglabra.
abstract: Following bioassay-directed fractionation procedures, two 7-oxygenated-8-prenylflavones, (-)-pseudosemiglabrin [1] and (-)-semiglabrin [2], were isolated from an MeOH extract of Tephrosia semiglabra. (-)-Pseudosemiglabrin [1] displayed in vitro inhibitory effects on human platelet aggregation.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
authors.forename: L T
authors.initials: LT
authors.lastname: Jonathan
authors.forename: M
authors.initials: M
authors.lastname: Gbeassor
authors.forename: C T
authors.initials: CT
authors.lastname: Che
authors.forename: H H
authors.initials: HH
authors.lastname: Fong
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: G C
authors.initials: GC
authors.lastname: Le Breton
authors.forename: D L
authors.initials: DL
authors.lastname: Venton
mesh_terms: D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification; D011450:Prostaglandin Endoperoxides, Synthetic
chemical_list: D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; C068536:pseudosemiglabrin