title: Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety.
abstract: The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 A and 102 kDa, respectively, down to a concentration of 2.0 x 10(-5) M.
authors.affiliation: Department of Medical Chemistry and Biochemistry, Medical School, University of Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sonnino
authors.forename: L
authors.initials: L
authors.lastname: Cantu
authors.forename: M
authors.initials: M
authors.lastname: Corti
authors.forename: D
authors.initials: D
authors.lastname: Acquotti
authors.forename: G
authors.initials: G
authors.lastname: Kirschner
authors.forename: G
authors.initials: G
authors.lastname: Tettamanti
mesh_terms: D000107:Acetylation; D002240:Carbohydrate Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005677:G(M1) Ganglioside / Q000737:chemistry*; D008027:Light; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012542:Scattering, Radiation; D013500:Surface Tension
chemical_list: D046911:Macromolecular Substances; D008823:Micelles; D005677:G(M1) Ganglioside