title: Biostatistical modeling of the effect of intravenous histamine-infusion on the rat gastric acid secretion.
abstract: In this study, a variety of linear and nonlinear biostatistical models of regression were tested to evaluate the histamine-induced gastric acid secretion using the lumen-perfusion model in the rat. Among the linear, parabolic, and polynomial models tested, 3rd- and 4th-order polynomial models of regression exerted best correlations between the time and histamine-induced gastric acid secretion. In order to avoid undulatory behaviors in the regression curves, we conducted the polynomial regression analysis up to 5th order.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Turkey.
authors.forename: A T
authors.initials: AT
authors.lastname: Ozçelikay
authors.forename: O
authors.initials: O
authors.lastname: Altinkurt
authors.forename: Y
authors.initials: Y
authors.lastname: Oztürk
authors.forename: N
authors.initials: N
authors.lastname: Yildizoğlu-Ari
authors.forename: V M
authors.initials: VM
authors.lastname: Altan
mesh_terms: D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis
chemical_list: D006632:Histamine