Effect of growth hormone on secretion of pregnancy-associated murine protein-1 (PAMP-1) in female and male rats.
The effect of 2 daily injections of human growth hormone (hGH) on serum levels of pregnancy-associated murine protein-1 (PAMP-1) was analysed in male and female Mol:WIST rats. In untreated control male rats the PAMP-1 level in the circulation is below the detection limit of rocket immunoelectrophoresis whereas females have a high serum level of PAMP-1. hGH treatment of male rats resulted in a dose-dependent increase in PAMP-1 concentration, whereas a similar treatment of female rats resulted in a significant decrease of the PAMP-1 concentration in serum. Methylprednisolone treatment either alone or in combination with hGH had no significant effect on the level of PAMP-1 in serum of male rats. It is concluded that the normal sexually determined different secretion pattern of PAMP-1 can be modified towards an intermediate pattern by administration of exogenous hGH.
Hau
J
J
Department of Veterinary Pathology, Royal Veterinary and Agricultural University, Frederiksberg Denmark.
Jørgensen
P H
PH
Poulsen
O M
OM
Bak
B
B
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000097:blood*; D011897:Random Allocation; D051381:Rats
D011257:Pregnancy Proteins; C033484:pregnancy-associated murine protein 1; D013006:Growth Hormone; D011239:Prednisolone