Effect of repeated treatment with electroconvulsive shock (ECS) on serotonin receptor density and turnover in the rat cerebral cortex.
The effect of repeated treatment with electroconvulsive shock (ECS) on 5-HT1A and 5-HT2 serotonin receptor density and on serotonin receptor turnover was measured in the rat cerebral cortex. Repeated treatment with ECS produced an increase in the density of 5-HT1A and tended to increase the specific binding of 5-HT2 serotonin receptors. However, the turnover of those receptors remained unchanged. These results are in agreement with previous studies which indicate that repeated ECS treatment up-regulates 5-HT2 receptors and support the contention that 5-HT1A receptors are up-regulated after repeated treatment with ECS; moreover, these data demonstrate that the dynamic characteristics (turnover rates) of serotonin receptors (5-HT1A, 5-HT2) are unaffected after repeated ECS administration.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland.
Dulinski
J
J
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*
D011985:Receptors, Serotonin