Endothelin-1 increases airway mucosa blood flow in the pig.
The vascular effects of bolus intravenous injections (4.5, 45 and 450 pmol.kg-1) of porcine endothelin-1 on the bronchial and nasal circulations were investigated in ten anesthetized pigs. Endothelin-1 produced a dose-dependent and long-lasting increase in bronchial blood flow with a concomitant rise in systemic arterial pressure suggesting vasodilatation. The highest doses of endothelin-1 also caused a slight decrease in the nasal vascular resistance. Furthermore, the vascular responses to endothelin-1 were not modified in systemically capsaicin pretreated animals or after pretreatment with a cyclocoxygenase inhibitor, diclofenac. Our results suggest that endothelin-1 has a potent and regional vasodiator effect of the bronchial circulation.
Matran
R
R
Laboratoire d'Explorations Fonctionnelles, Hôpital Cochin, Paris, France.
Alving
K
K
Hemsen
A
A
Lundberg
J M
JM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000098:blood supply*; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D009296:Nasal Cavity / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D016232:Endothelins; D014665:Vasodilator Agents