[The calcium-binding properties of plasma proteins following the allograft of a cadaveric kidney].
The kinetics of calcium binding to plasma proteins in hypo- and hypercalcaemia, induced in vitro, were studied in 60 patients after renal transplantation. Langmuir and Scatchard analysis revealed the normal binding of calcium to plasma proteins in 10 patients (cooperative mechanism of calcium-protein interaction in hypocalcaemic state and existence of one or several sets of calcium binding independent sites in hypercalcaemic state). Cooperative binding with the decreased values of effective Ka, effective n. molar binding ratio (CaPr/A) and specific buffer capacity (beta sp.) were observed in 1/3 patients. Cooperative mechanism of calcium-proteins interaction has not been observed in more than 1/2 patients and the values of n. CaPr/A, beta sp, decreased in most of the patients. The observed changes may be caused by a proteins metabolism deterioration and may result in deterioration of calcium homeostasis.
Ermakova
I P
IP
Sokolova
T Iu
TIu
Pronchenko
I A
IA
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002118:Calcium / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood; D006996:Hypocalcemia / Q000097:blood; D016030:Kidney Transplantation / Q000502:physiology*; D008875:Middle Aged; D011184:Postoperative Period; D014184:Transplantation, Homologous
D002135:Calcium-Binding Proteins; D002118:Calcium
Kal'tsiĭsviazyvaiushchie svoĭstva plazmennykh belkov posle allotransplantatsii trupnoĭ pochki.