Ovulation-inducing activity of luliberin (LHRH) complexed by copper(II), nickel(II), and zinc(II) ions.
We have shown that the complexation of luteinizing hormone releasing hormone, luliberin (LHRH), a hypothalamic neurohormone, by Cu(II), Ni(II), and Zn(II) may affect its basic, ovulation-inducing potency in the dose responsive manner. Some explanation of the obtained results are offered here.
Kozlowski
H
H
Institute of Chemistry, University of Wroclaw, Poland.
Masiukiewicz
E
E
Potargowicz
E
E
Rzeszotarska
B
B
Walczewska-Sumorok
A
A
D000595:Amino Acid Sequence; D000818:Animals; D003300:Copper; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008969:Molecular Sequence Data; D009532:Nickel; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D051381:Rats; D011915:Rats, Inbred BUF; D011919:Rats, Inbred Strains; D015032:Zinc
D007987:Gonadotropin-Releasing Hormone; D003300:Copper; D009532:Nickel; D015032:Zinc