[The receptor binding of corticosterone in the monoaminergic structures of the rat brain after a neonatal block of the hypophysis-adrenal system].
Specific binding of 3H-corticosterone in different cerebral structures of 1- and 2-month-old rats was studied after neonatal blockade of the hypophyseal-adrenal system caused by hydrocortisone administration (0.1 mg per animal during the first 5 days of the life of rats). Neonatal administration of the hormone caused a decrease in receptor binding of 3H-corticosterone in the hypothalamus, pituitary body, striatum, black substance and blue spot in 1-month-old animals. In 2-month-old animals specific binding of the hormone in all the investigated structures was restored up to the control level. Regeneration of hormonal function was noted in the same period. The results indicate the involvement of the central monoaminergic structures in the regulation of the hypophyseal-adrenal system after the feedback-type mechanism.
Garina
I A
IA
Rakitskaia
V V
VV
Shaliapina
V G
VG
D000315:Adrenalectomy; D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism*; D003864:Depression, Chemical; D006854:Hydrocortisone / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D011987:Receptors, Steroid
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D003345:Corticosterone; D006854:Hydrocortisone
Retseptornoe sviazyvanie kortikosterona v monoaminergicheskikh strukturakh mozga krys posle neonatal'noĭ blokady gipofiz-adrenalovoĭ sistemy.