title: [Hyperthermic-antiblastic isolation perfusion for advanced melanoma of the limbs. The technic, immediate results and a review of the literature].
abstract: Hyperthermic antiblastic isolated perfusion is a method largely used for the treatment of locally advanced limb melanoma. The method requires vascular isolation and hyperthermic perfusion of the limb using an extracorporeal circuit and administering the melphalan as antiblastic drug. Twenty-six patients with primary or recurrent melanoma of the limbs have undergone this treatment at our Institute. There were no cases of operative mortality and systemic toxicity was negligible. The local complications were transitory and no patient showed symptoms of nervous toxicity or permanent functional damage. Two cases of deep thrombophlebitis and two of lymphocele were documented a few months after treatment. Four clinically complete responses, 3 partial and 2 cases of stable disease were observed in the 9 patients treated with unexcised lesions. Our data like the totality of the present experience points to the safety of this method in the therapy of locally advanced limb melanoma. Nevertheless further controlled studies are required to define its role in order to improve survival.
authors.affiliation: Cattedra di Cardiochirurgia, Università di Genova.
authors.forename: F
authors.initials: F
authors.lastname: Decian
authors.forename: N
authors.initials: N
authors.lastname: Balletto
authors.forename: G
authors.initials: G
authors.lastname: Camerini
authors.forename: M
authors.initials: M
authors.lastname: Depaoli
authors.forename: R
authors.initials: R
authors.lastname: D'Aniello
authors.forename: A
authors.initials: A
authors.lastname: Ameri
authors.forename: A
authors.initials: A
authors.lastname: Brisighella
authors.forename: U
authors.initials: U
authors.lastname: Bonalumi
authors.forename: V
authors.initials: V
authors.lastname: Bachi
authors.forename: D
authors.initials: D
authors.lastname: Civalleri
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001132:Arm; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D007866:Leg; D008545:Melanoma / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008558:Melphalan / Q000008:administration & dosage*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011187:Posture
chemical_list: D008558:Melphalan
vernacular_title: La perfusione isolata ipertermico-antiblastica per il melanoma avanzato degli arti. Tecnica, risultati immediati e revisione della letteratura.