[Study of the DNA-damaging activity of the mutagenic derivative of tetrahydrodiazapyrene, DDDTDP].
2,7-diamino-4,9-dioxo-5,10-dioxy-4,5,9,10-tetrahydro-4.9--diaza prein (DDDTDP)--the frameshift mutagen--induced frameshift mutations in indicator strain Salmonella typhimurium. The mutagen displays strong DNA damaging activity in murine L cell line. The DNA was analyzed for single strand breaks by alkaline elution assay. Analysis of reparation of DNA breaks suggests that DDDTDP acts as bifunctional agent.
Abilev
S K
SK
Abdrazakov
M M
MM
D002478:Cells, Cultured; D003432:Cross-Linking Reagents; D004249:DNA Damage; D016368:Frameshift Mutation; D009153:Mutagens; D011721:Pyrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics
C018644:2,7-diamino-4,9-dihydroxy-5,10-dioxo-4,5,9,10-tetrahydro-4,9-diazapyrene; D003432:Cross-Linking Reagents; D009153:Mutagens; D011721:Pyrenes
Izuchenie DNK-povrezhdaiushcheĭ aktivnosti mutagennogo proizvodnogo tetragidrodiazapirene DDDTDP.