title: [CNS-active substances: synthesis of epoxybenzoxocines].
abstract: The 2-(2-Bromophenyl)-acetaldehyde acetals 8 are treated with n-BuLi and the aldehydes 7 and 11 to form the hydroxyacetales 9 and 12, respectively. 9 is cyclized under acidic conditions to the epoxybenzoxocine 2; analogously 12 yields the epoxydibenzoxocine 14.
authors.affiliation: Institut für Pharmazie und Lebensmittelchemie, Universität München.
authors.forename: B
authors.initials: B
authors.lastname: Wünsch
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001643:Bridged Bicyclo Compounds; D002491:Central Nervous System Agents; D004852:Epoxy Compounds
vernacular_title: ZNS-Wirkstoffe: Synthese von Epoxybenzoxocinen.