Prostacyclin and vascular function: implications for hypertension and atherosclerosis.
Prostacyclin and endothelium-derived relaxing factor (or nitric oxide) are unstable mediators produced by the vascular endothelium, that are important for local regulation of platelet behavior and blood flow. This review focuses on the basic biochemistry and pharmacology of prostacyclin, its interactions with nitric oxide and nitrovasodilator drugs, and the implications of disturbances in this system for vascular disease, particularly hypertension and atherosclerosis. Prostacyclin and its stable analogs are also finding limited therapeutic applications in preservation of platelet function, pulmonary hypertension, and investigation into the cytoprotective and antiatherosclerotic properties is continuing.
Dusting
G J
GJ
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
MacDonald
P S
PS
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001095:Arachidonic Acids / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*
D000959:Antihypertensive Agents; D001095:Arachidonic Acids; D011464:Epoprostenol