Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis.
Two consecutive open studies were performed of the efficacy of a prophylactic cefuroxime/metronidazole combination in abdominal hysterectomy. The first group received a 24-h regimen, the second group a single pre-operative dose. The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]. No significant differences in other parameters, such as pyrexia and duration of post-operative hospitalization, could be detected.
Eckenhausen
F W
FW
Department of Obstetrics and Gynaecology, Refaja Hospital, Stadskanaal, The Netherlands.
Jonker
P L
PL
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D015994:Incidence; D007275:Injections, Intravenous; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D013997:Time Factors; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014946:Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002444:Cefuroxime