title: [Implant study of glass-ceramics in rat femurs--evaluations for dental implant applications].
abstract: In order to evaluate the possibility of dental implant application of glass-ceramics (GC), an implant study using rat femurs was performed. This GC contains crystalline apatite, wollastonite and diopside in a CaO-P2O5-MgO-SiO2-CaF2 glassy matrix. The cylindrical GC were implanted in the drilled holes of the femurs and the histologic reactions to the GC and the crystallographic changes of the GC were investigated at the timed sequence for one year. The GC provoked the endosteal bone formation. The intervening fibrous tissue between the encapsulating bone and the GC was replaced by bone tissue which was outgrowing from the encapsulating bone surface. Finally, the interface between them was bonded. The surface layer of the GC was changed morphologically and crystallographically. During these bonding phenomena, the X-ray intensities of Ca, P, Si and Mg and the crystalline pattern of the apatite crystal in this reactive zone changed. These changes might be closely related to the bone-bonding between the encapsulating bone and the GC. These results indicate the excellent biocompatibility of the GC and suggest the effective clinical application of the GC as a dental implant.
authors.affiliation: Department of Stomatognathic Dysfunction, Faculty of Dentistry, Tokyo Medical and Dental University.
authors.forename: M
authors.initials: M
authors.lastname: Nakano
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002516:Ceramics; D015921:Dental Implants; D005269:Femur / Q000502:physiology*; D005898:Glass; D008297:Male; D010012:Osteogenesis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants