title: Effect of two sodium fluoride dentifrices on fluoride uptake and remineralization in situ.
abstract: Two dentifrices containing 1100 ppm F from sodium fluoride in silica bases were compared to a placebo dentifrice in an in situ remineralization and fluoride uptake study. Fifteen subjects brushed artificially-formed caries lesions in 60 thin enamel sections and 30 enamel blocks with each dentifrice in a double-blind, randomized, cross-over study design. Analysis of the thin sections by quantitative microradiography before and after exposure to toothbrushing showed that the fluoride dentifrices produced 18.3% and 7.1% remineralization whereas use of the placebo resulted in 10.3% demineralization. The differences between all three dentifrices were statistically significant. Fluoride concentrations at the surface of the lesion increased from approximately 700 ppm F in untreated specimens to approximately 1800 ppm F in specimens treated with either of the two fluoride dentifrices. These data suggest that formulation differences may affect the anticaries activity of a dentifrice without being reflected by fluoride deposition.
authors.affiliation: Colgate-Palmolive Company, Piscataway, New Jersey.
authors.forename: J R
authors.initials: JR
authors.lastname: Mellberg
authors.forename: I D
authors.initials: ID
authors.lastname: Petrou
authors.forename: N
authors.initials: N
authors.lastname: Grote
mesh_terms: D006801:Humans; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014089:Tooth Remineralization; D014100:Toothpastes
chemical_list: D014100:Toothpastes; D012969:Sodium Fluoride