title: UVA irradiation increases the incidence of epithelial tumors in UVB-irradiated hairless mice.
abstract: The interaction of UVA and UVB radiation in tumorigenesis in lightly pigmented hairless hr/hr mice was studied. Seventy-eight tumors (5 sarcomas, 4 squamocellular carcinomas, 1 carcinosarcoma, 63 papillomas, 2 keratoacanthomas, 1 fibrous polyp and 2 adnexal tumors) occurred in 12 mice receiving high UVA (582 J/cm2) plus high UVB(EE) (erythemally effective) (1.0 J/cm2) doses, whereas only 28 tumors (6 sarcomas, 1 carcinosarcoma, 20 papillomas and 1 keratoacanthoma) were found in 12 mice receiving low UVA (71 J/cm2) plus high UVB(EE) (0.8 J/cm2) doses. In 12 mice receiving low doses of both UVA and UVB(EE), only 2 tumors (sarcomas) occurred. The predominantly epidermal tumor response in the high UVA-high UVB group suggests that UVA irradiation increases the number of epithelial tumors when given together with carcinogenic doses of UVB radiation.
authors.affiliation: Department of Pathology, University of Turku, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Talve
authors.forename: F
authors.initials: F
authors.lastname: Stenbäck
authors.forename: C T
authors.initials: CT
authors.lastname: Jansén
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D011829:Radiation Dosage; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014466:Ultraviolet Rays