title: Carbapenem and penem antibiotics. V. Synthesis and antibacterial activity of 2-functionalized-methyl 1-methylcarbapenems related to asparenomycins.
abstract: The synthesis of 1 alpha- and/or 1 beta-methylcarbapenems, 2-unsubstituted and 2-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl derivatives having a 1-(hydroxy)methylethylidene or cyclic carbonate side chain at the C-6 position, is described. The in vitro antibacterial activities of these compounds and their corresponding 1-unsubstituted carbapenems are compared.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Imuta
authors.forename: S
authors.initials: S
authors.lastname: Uyeo
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D013845:Thienamycins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D013845:Thienamycins; C031989:asparenomycin