Pirenzepine, telenzepine, atropine and metacine as agonists for the muscarinic cholinoreceptors in the denervated human parotid gland.
New anti-ulcer preparations, pirenzepine and telenzepine, are structurally dissimilar to the classical cholinomimetics, atropine and hyoscine (scopolamine). However, they are all capable of provoking paradoxical salivation from the chronically parasympathetically denervated human parotid gland. The rates of the secretory responses to the typical and atypical cholinoblockers are found to be the same. This finding is discussed with respect to the general functional mechanism of the traditional and non-traditional antimuscarinic agents.
Levin
S L
SL
Clinic for Nervous Diseases of the Pediatric Medical College, Leningrad, U.S.S.R.
D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001561:Benzilates / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D010275:Parasympathetic Nervous System / Q000293:injuries; D010306:Parotid Gland / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D001561:Benzilates; D011976:Receptors, Muscarinic; C046338:telenzepine; C053908:metacine; D010890:Pirenzepine; D001285:Atropine; D002794:Choline