title: [Transient large granular lymphocytosis associated with pulmonary tuberculosis: a case report].
abstract: We report a case of a 61-year-old woman with large granular lymphocytosis associated with pulmonary tuberculosis. She was admitted to our hospital because of high fever, anemia and splenomegaly. On admission, the leukocyte count was 6,890/microliters with 52% of large granular lymphocytes. Immunophenotypical analysis of the increased cells showed following results; CD2+, CD3-, CD16+, CD57+. These cells had natural killer (NK) activity. Molecular genetical analysis showed these cells had germline configuration of the T cell receptor beta chain genes. About four months after admission, chest X-P revealed multiple mass shadow and the diagnosis of pulmonary tuberculosis was made by the examination of gastric juice. Anti-tuberculosis therapy was started, and soon after clinical symptom and pancytopenia were improved. For about one year, anti-tuberculosis therapy was continued, and now hematological abnormality is not found. We considered that this case was reactive large granular lymphocytosis of NK cells to lung tuberculosis.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Otsuji
authors.forename: N
authors.initials: N
authors.lastname: Otsuji
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Sekine
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: N
authors.initials: N
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Kita
authors.forename: S
authors.initials: S
authors.lastname: Shirakawa
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD