[The effect of triamcinolone acetonide on the liver mitochondria in endotoxemia].
Endotoxin Salmonella typhimurium (LD50) was administered intraperitoneally to mice. It was shown that triamcinolone acetonide in a dose of 1 mg/kg living weight administered to mice 1 hour before endotoxin administration completely prevents the death of the animals and decreases the level of changes in the activities of enzymes of glutamate dehydrogenase, succinate dehydrogenase, monoaminoxidase, cytochrome oxidase in the liver mitochondria in endotoxemia. The level of lipid peroxidation in mitochondria during endotoxemia against the background of triamcinolone acetonide action is close to control. The use of triamcinolone acetonide in the absence of the effect of endotoxin results in an insignificant damage of mitochondrial membranes.
Natanzon
L V
LV
Artiukhina
A I
AI
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D012486:Salmonella typhimurium; D014115:Toxemia / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology; D014222:Triamcinolone Acetonide / Q000009:adverse effects / Q000627:therapeutic use*
D004731:Endotoxins; D014222:Triamcinolone Acetonide
Vliianie triamtsinolona atsetonida na mitokhondrii pecheni pri éndotoksemii.