title: Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques.
abstract: We were able to refine the chromosomal position of two existing marker loci, using an extended chromosome 21 somatic cell hybrid panel. The locus D21S26 mapped in the region 21q11.2-q21.1, and the locus D21S24 in 21q22.1-q22.2. Physical and genetic analysis indicated that D21S26 is tightly linked to D21S13 and D21S16, two markers previously linked to familial Alzheimer's disease.
authors.affiliation: Department of Biochemistry, Born-Bunge Foundation, University of Antwerp (UIA), Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Van Hul
authors.forename: H
authors.initials: H
authors.lastname: Backhovens
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
authors.forename: P
authors.initials: P
authors.lastname: Stinissen
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: A
authors.initials: A
authors.lastname: Wehnert
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D066298:In Vitro Techniques
chemical_list: D005819:Genetic Markers