3-O-methyl-D-glucose uptake by erythrocytes of normal and diabetic subjects.
The uptake of 3-O-[14C]methyl-D-glucose was measured in erythrocytes of normal and non-insulin-dependent diabetic subjects. In normal subjects, the uptake of the sugar was rapid, saturable, temperature-sensitive and inhibited by cytochalasin B. Over 30 s incubation at 20 degrees C, the uptake of 3-O-[14C]methyl-D-glucose (20 mM) was lower in diabetic than in normal subjects. These findings raise the view that an alteration of hexose transport into insulin-insensitive cells may participate to the perturbation of glucose homeostasis in diabetic patients.
Gomis
R
R
Endocrinology and Diabetes Unit, Hospital Clinic, Barcelona, Spain.
Tomas
C
C
Novials
A
A
Malaisse
W J
WJ
D019325:3-O-Methylglucose; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008757:Methylglucosides / Q000097:blood*; D008875:Middle Aged
D008757:Methylglucosides; D019325:3-O-Methylglucose