Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw--effects of PGD2, PGE2 and PGI2.
The relative potencies of PGD2, PGE2 and PGI2 in potentiating bradykinin-induced hyperalgesia and oedema were determined in the paws of aspirin-treated guinea-pigs. PGE2 and to a lesser degree PGD2 but not PGI2, potentiated bradykinin-induced hyperalgesia, whereas PGD2, but not PGE2 or PGI2, potentiated oedema. These findings differ from those in other species, and possibly reflect interspecies differences in modulation of inflammatory reactions by prostanoids.
Whelan
C J
CJ
Department of Peripheral Pharmacology, Glaxo Group Research Ltd., Ware, Herts., U.K.
Head
S A
SA
Poll
C T
CT
Coleman
R A
RA
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D015230:Prostaglandin D2 / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D012684:Sensory Thresholds / Q000187:drug effects
D011453:Prostaglandins; D011464:Epoprostenol; D015232:Dinoprostone; D001241:Aspirin; D015230:Prostaglandin D2; D001920:Bradykinin