title: Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function.
abstract: Cultured epithelial cells obtained from guinea pig tracheal preparations metabolized arachidonic acid into 5- and 15-hydroxy-eicosatetraenoic acid and into the prostaglandins E2 and F2 alpha. Linoleic acid was converted by the epithelial cells into 9-hydroxy-octadecadienoic acid (9-HODE) and smaller amounts of 13-HODE. It was further investigated whether linoleic acid metabolites are of importance for the regulation of airway smooth muscle function. 13-HODE caused an increase of maximal contraction of tracheal rings to histamine, while 9-HODE had no effect.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Henricks
authors.forename: F
authors.initials: F
authors.lastname: Engles
authors.forename: B
authors.initials: B
authors.lastname: van Esch
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Linde
authors.forename: M J
authors.initials: MJ
authors.lastname: Oosthuizen
authors.forename: F P
authors.initials: FP
authors.lastname: Nijkamp
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism / Q000502:physiology; D006632:Histamine / Q000494:pharmacology; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism* / Q000494:pharmacology; D044243:Linoleic Acids, Conjugated; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D014132:Trachea / Q000166:cytology / Q000378:metabolism / Q000502:physiology*
chemical_list: D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; C024347:9-hydroxy-10,12-octadecadienoic acid; C024348:13-hydroxy-9,11-octadecadienoic acid; D006632:Histamine; D019787:Linoleic Acid