title: Antimicrobial activity of a new derivative: N-(4-chlorobenzyl)-2-(1H-imidazol-1-ylmethyl)benzenamine.
abstract: The activity of a new antifungal agent, an imidazolylmethylaniline derivative (XX H), synthesized by the authors, has been studied in vitro and in vivo. Antimicrobial data, in comparison with miconazole, ketoconazole and bifonazole, show antimicotic activity. The results are discussed on the basis of structure-activity relationships.
authors.affiliation: Institute of Microbiology, University of Rome La Sapienza, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Panico
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.forename: N
authors.initials: N
authors.lastname: Simonetti
authors.forename: G C
authors.initials: GC
authors.lastname: Porretta
authors.forename: M
authors.initials: M
authors.lastname: Scalzo
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology; D008297:Male; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011817:Rabbits
chemical_list: D000814:Aniline Compounds; D000935:Antifungal Agents; D007093:Imidazoles; C067916:N-(4-chlorobenzyl)-2-(1H-imidazol-1-ylmethyl)benzenamine; D008825:Miconazole; C036596:bifonazole; D007654:Ketoconazole