[Value of partial protection of lung tissue for prevention of radiation pneumonitis after total body irradiation].
Interstitial pneumonitis is one of the most serious complications in patients after bone marrow transplantation, and irradiation plays the main role in its etiology. A total of 44 patients with blood diseases were subjected to total-body irradiation before bone marrow transplantation. Chemotherapy, cyclophosphamide in a dose of 60 mg/kg/day, was conducted during two successive days. Group I patients (n-23) were subjected to irradiation in a total dose of 12 Gy used as 6 fractions of 2 Gy twice a day, during 3 successive days. Group II patients, after irradiation with 6 Gy, were protected with lung shields that inhibited 50% of irradiation thus reducing the irradiation dose in the area of the lung up to 9 Gy. Then the patients received a total dose of 6 Gy during two days. Radiation pneumonitis developed in 6 out of 23 patients, 3 of them died. No non-infectious complications of the lungs were observed in group II patients with partial protection of the lung tissue. The data obtained have evidenced that thoroughly developed radiotherapeutic program with a special attention to the prevention of excessive irradiation of the lung tissue can reduce incidence of radiation pneumonitis in patients after bone marrow transplantation.
Veshler
Z
Z
Slavin
Sh
Sh
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D002648:Child; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D008168:Lung / Q000528:radiation effects*; D008875:Middle Aged; D011182:Postoperative Care; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000517:prevention & control*; D011832:Radiation Injuries / Q000150:complications / Q000517:prevention & control*; D011835:Radiation Protection / Q000379:methods*; D014916:Whole-Body Irradiation / Q000009:adverse effects*
Znachenie chastichnoĭ zashchity legochnoĭ tkani v preuprezhdenii luchevogo pnevmonita posle total'nogo oblucheniia organizma.