title: Reversibility of blue-gray cutaneous discoloration from amiodarone.
abstract: A 45-year-old man had severe blue-gray cutaneous discoloration during amiodarone therapy for atrial fibrillation. Therefore, this drug regimen was discontinued, and long-term anticoagulation and digoxin therapy were used. The patient was advised to avoid exposure of his skin to sunlight, and a bleaching agent was prescribed. After 18 months of follow-up, the blue-gray hyperpigmentation had diminished. Although photosensitivity reactions from amiodarone occur in more than 50% of patients, blue-gray cutaneous discoloration occurs in less than 10% of patients on prolonged therapy with amiodarone. The presence of high concentrations of iodine, detected by electron probe analysis, suggests that the cutaneous deposits are amiodarone itself or a metabolite. The slow rate of elimination of amiodarone and a high uptake by fat-associated tissues may explain the delayed disappearance of cutaneous photosensitivity and late resolution of the blue-gray discoloration. Our current case supports the reversibility of these adverse effects on long-term follow-up.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224.
authors.forename: J L
authors.initials: JL
authors.lastname: Blackshear
authors.forename: H W
authors.initials: HW
authors.lastname: Randle
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000150:complications; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000150:complications / Q000473:pathology
chemical_list: D000638:Amiodarone