title: Long-term pergolide treatment of hyperprolactinemic patients previously unsuccessfully treated with dopaminergic drugs.
abstract: Nine hyperprolactinemic patients (seven women aged 25-57 and two men aged 23-51 years) were treated with the dopamine agonist drug, pergolide mesylate, for a period ranging from 4 months to 5 years. All patients had previously received different dopamine agonist drugs; additionally two of the group had undergone surgery and radiation therapy. Group 1 comprised five patients who were given pergolide in an attempt to avoid the marked side effects of bromocriptine and lisuride that had been given earlier. Group 2 comprised four patients treated with pergolide following failure to respond to other dopamine agonist drugs (bromocriptine, lisuride). In group 1, pergolide, at a dose of 25-50 micrograms/day, caused a decrease in the prolactin level to the normal value, restored menstruation, and very few side effects were noted. In group 2, pergolide was administered in a gradually increasing dose, the patients receiving a maximum of 200 micrograms/day. At this dose, there was a significant decrease in the prolactin level in two patients compared with only a slight decrease in the remaining two patients. This study illustrates the efficacy of pergolide in treating hyperprolactinemic patients unable to tolerate other dopaminergic agents (bromocriptine, lisuride).
authors.affiliation: Institute of Endocrinology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Berezin
authors.forename: D
authors.initials: D
authors.lastname: Avidan
authors.forename: E
authors.initials: E
authors.lastname: Baron
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D008090:Lisuride / Q000009:adverse effects / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010479:Pergolide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D010479:Pergolide; D001971:Bromocriptine; D011388:Prolactin; D008090:Lisuride