title: [New derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepine-11-ones with anticholinergic activity].
abstract: Starting from 2-aminobenzoic acid and correspondingly substituted 2-chloronitrobenzenes, 5-substituted-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin -11- one derivatives with a differently high activity on ulcers were prepared. 8-Chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)a-minoacetyl]-11H- dibenzo[b,e][1,4]diazepin-11-one hydrochloride (AWD 26-06) was selected for further clinical evaluation.
authors.affiliation: Geschäftsbereich Forschung und Entwicklung Arzneimittelwerk Dresden GmbH.
authors.forename: C
authors.initials: C
authors.lastname: Rüger
authors.forename: H
authors.initials: H
authors.lastname: Röhnert
authors.forename: D
authors.initials: D
authors.lastname: Lohmann
mesh_terms: D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D003984:Dibenzazepines / Q000138:chemical synthesis; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001570:Benzodiazepinones; D003984:Dibenzazepines; D010276:Parasympatholytics; C060713:AWD 26-06
vernacular_title: Neue Derivate des 5,10-Dihydro-11H-dibenzo[b,e][1,4]diazepin-11-on mit anticholinerger Wirkung.