Studies on sucrose-palmitate-stearate-containing vesicles encapsulating the cytostatic drug methylglyoxal-bis-guanyl-hydrazone.
Vesicles prepared from sucrose-palmitate-stearate and cholesterol encapsulating the anticancer drug methylglyoxal-bis-guanylhydrazone, were investigated. Treatment with drug-loaded vesicles of this composition in a q.d. 1-4 schedule resulted for murine leukemias P388 in nearly the same increase in life span as the corresponding dose of the free drug. Even very high dosages of sucrose-palmitase-stearate (up to 480 mg.kg-1.d-1) were tolerated by mice.
Schenk
P
P
Sektion Pharmazie der Martin-Luther-Universität Halle-Wittenberg, Wissenschaftsbereich Pharmazeutische Chemie.
Nuhn
P
P
Fichtner
I
I
Arndt
D
D
D000818:Animals; D002214:Capsules; D005079:Excipients; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008935:Mitoguazone / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D010168:Palmitates; D013228:Stearates; D013395:Sucrose
D002214:Capsules; D005079:Excipients; D010168:Palmitates; D013228:Stearates; D013395:Sucrose; D008935:Mitoguazone