title: Growth hormone deficiency of hypothalamic origin in septo-optic dysplasia.
abstract: Hypothalamic pituitary function and growth hormone releasing hormone (GHRH) loading tests in two children with septo-optic dysplasia (SOD) revealed isolated GH deficiency in one and deficiencies of growth hormone, adrenocorticotropic hormone and antidiuretic hormone in the other. Secretion of GH was elicited in the first patient by single i.v. bolus administration of GHRH and after repetitive i.v. infusions of GHRH in the second. With these results we confirmed that the hypopituitarism in our patients with SOD was of hypothalamic origin. Both patients also had infantile spasms.
authors.affiliation: Department of Paediatrics and Child Health, School of Medicine, Kurume University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yukizane
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Matsuishi
authors.forename: H
authors.initials: H
authors.lastname: Horikawa
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: F
authors.initials: F
authors.lastname: Yamashita
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D001921:Brain / Q000002:abnormalities*; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology* / Q000503:physiopathology; D007031:Hypothalamus / Q000503:physiopathology*; D007223:Infant; D008297:Male; D009900:Optic Nerve / Q000002:abnormalities; D013961:Thyroid Gland / Q000502:physiology
chemical_list: D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone