[The cytofluorimetric characteristics of monoclonal antibodies for use in humans in respect of their activity and cross reactivity].
A cytofluorimetric method for determination of the reactivity of antimyeloma MkAt 225,28S with myeloma cells and blood elements is described in the present article. The obtained results show that the antibody possesses high specific activity and does not bind with normal human lymphocytes, monocytes, granulocytes, thrombocytes and erythrocytes in the examined dilutions. The method is suitable for control of cross reactivity with blood cells of MkAt preparations for usage in subjects.
Davidkova
G
G
Taskov
Kh
Kh
Dimitrova
E
E
Gencheva
G
G
D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000276:immunology; D000918:Antibody Specificity; D015703:Antigens, CD / Q000276:immunology; D001773:Blood Cells / Q000276:immunology; D003429:Cross Reactions; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008545:Melanoma / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD
Tsitofluorimetrichna kharakteristika na monoklonalni antitela za prilozhenie pri khora po otnoshenie na aktivnost i krŭstosana reaktivnost.