[Bacterial infection in the newborn by maternal-fetal contamination: oral antibiotic treatment of the colonized newborn. Prospective study at a maternity unit].
It is not yet known how important bacterial colonisation of the newborn is but in most maternity units this, when it occurs, is treated by parenteral antibiotic therapy. We have, in a prospective study, given antibiotics orally (amoxycillin or clavulanic acid-amoxycillin) in neonates who were colonised by bacteria, and have studied their clinical progress in the first month of life, using a questionnaire to be filled in by the parents. There were 119 neonates treated in 19 months and of these 87.4% of the parents replied to the questionnaires. The children did well in every case. A pharmacokinetic study showed that 76% of the amoxycillin given by mouth was absorbed. It seems, therefore, to us to be useful to give antibiotic treatment by mouth in these neonates.
Blond
M H
MH
Centre de Pédiatrie Gatien de Clocheville, CHRU de Tours.
Gold
F
F
Marchand
S
S
Pierre
F
F
Congard
B
B
Soutoul
J H
JH
Laugier
J
J
D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009725:Nurseries, Hospital; D011446:Prospective Studies; D011795:Surveys and Questionnaires
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Infection bactérienne du nouveau-né par contamination materno-foetale: traitement antibiotique par voie orale du nouveau-né colonisé. Etude prospective dans une maternité.