title: [Prostaglandin E1 in the treatment of chronic ischemia of the extremities].
abstract: The authors observed the effect of prostaglandin E1 (Prostavasine) on the blood flow in the lower extremities in 25 patients with chronic ischemia caused by thrombo-angitis obliterans and arteriosclerosis obliterans (clinical stage III and IV). The blood flow in the lower extremities and the effects of prostaglandin E1 were assessed by means of rheo-angiographic and Doppler-testing investigations. The parameters A (amplitude), S (area) and WOT (index) of rheo-angiographic curves showed significant increased. No significant changes were found in the determined Doppler's indexes. The observed differences of values the parameters of rheo-angiographic curves suggests that prostaglandin E1 evident improvement the tissue blood flow in patients with critical ischemia of the lower extremities. The authors found that prostaglandin E1 was without any significant effect dilating the great vessels, but an evident improvement was observed in rheo-angiographic records which reflect rather the blood flow values in the small vessels.
authors.affiliation: Katedry i Kliniki Angiologil Akademn Medycznej we Wrocławin.
authors.forename: B
authors.initials: B
authors.lastname: Kowal-Gierczak
authors.forename: M
authors.initials: M
authors.lastname: Kurzawska-Mielecka
authors.forename: M
authors.initials: M
authors.lastname: Czarnacki
mesh_terms: D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D013919:Thromboangiitis Obliterans / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000527:Alprostadil
vernacular_title: Prostaglandyna E1 w leczeniu przewlekłego niedokrwienia konczyn.