title: Microtubules of guinea pig cochlear epithelial cells.
abstract: By tannic acid staining, the 13-protofilament composition of cochlear hair cell microtubules, an impressive contrast against the 15-protofilament microtubules in cochlear pillar cells, was verified. The 15-protofilament microtubules formed a large and stiff cytoskeletal bundle in pillar cell bodies involving abundant actin filaments. The bundles were always situated vertically, i.e., longitudinally to the cell body axis, and were most numerous in the outer as well as the inner pillar cells in the basal turn, decreasing gradually toward the apex. Such gradient architecture of the pillar cell cytoskeleton can be correlated with the tuning mechanism for traveling waves of sound containing variable frequencies.
authors.affiliation: Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: T
authors.initials: T
authors.lastname: Takasaka
authors.forename: A
authors.initials: A
authors.lastname: Tonosaki
authors.forename: Y
authors.initials: Y
authors.lastname: Katori
authors.forename: H
authors.initials: H
authors.lastname: Shinkawa
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure*; D006199:Hair Cells, Auditory, Inner / Q000648:ultrastructure; D047348:Hydrolyzable Tannins; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure*
chemical_list: D047348:Hydrolyzable Tannins