[The presence of antithyroid antibodies in the blood serum of patients with diffuse toxic goiter before and during treatment].
The level of antibodies to thyroglobulin (Ab-TG), microsomal fraction (Ab-ME) and plasma membranes of thyrocytes (PMT) was investigated in patients with Basedow's disease using the DELFIA method. Altogether 81 patients were investigated before the onset of therapy, of them 44-3 and 12 mos. after thiamazole therapy. Before the onset of therapy among 81 patients Ab-MF were detected in 55, Ab-TG--in 69, Ab-PMT--in 70, exceeding considerably (p less than 0.05) the respective indices in the control group. During investigation of 44 patients the following indices were detected in 3 mos.: Ab-TG--in 35 patients, Ab-MF--in 26, and Ab-PMT--in 35; in 12 mos.: these indices were detected in 21, 15 and 23 patients, respectively. A significant decrease in the detectability (p less than 0.05) of Ab-TG, Ab-MF and Ab-PMT was noted one year after the onset of thiamazole therapy.
Khalling
T A
TA
Iarvekiul'g
L V
LV
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D015200:Fluoroimmunoassay / Q000295:instrumentation / Q000379:methods; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*
D001323:Autoantibodies; D008713:Methimazole; D013954:Thyroglobulin
Nalichie antitireoidnykh antitel v syvorotke krovi u bol'nykh diffuznym toksicheskim zobom do i vo vremia lecheniia.