Enhancement of virulence of two environmental strains of Vibrio vulnificus after passage through mice.
The virulence of two environmental strains of Vibrio vulnificus to iron-loaded adult mice was enhanced by passage through mice. Estimates of 50% lethal dose values (LD50) determined by end point titration were reduced 100- and 1000-fold for the two strains. Passage through mice also selected for the opaque colony type phase variation of V. vulnificus, reported by others to be more virulent to mice than a translucent colony type.
Kaysner
C A
CA
Seafood Products Research Center, Food and Drug Administration, Bothell, Washington 98041-3012.
Wekell
M M
MM
Abeyta
C
C
D000818:Animals; D015169:Colony Count, Microbial; D051379:Mice; D012692:Serial Passage; D014733:Vibrio / Q000254:growth & development / Q000472:pathogenicity*; D014735:Vibrio Infections / Q000382:microbiology*; D014774:Virulence