Lack of effect of peritoneal endometriosis on fertility in the rabbit model.
OBJECTIVE
To study the isolated influence of peritoneal endometrial implants on fertility in an adhesion-free rabbit model.


METHODS
Thirty-two rabbits with endometrium implants were used; 31 rabbits with fat implants served as controls. In these rabbits parameters of early embryonic development were investigated.


RESULTS
No significant differences were noted in ovulation, ovum pick-up, fertilization, tubal transport, and embryonic and fetal development.


CONCLUSIONS
In the adhesion-free rabbit model, peritoneal implants of endometriosis do not have an effect on fertility. This supports the contention that therapies focused toward the implants are unlikely to change the pregnancy outcomes. Alternatively, it may cast doubts onto the relevance of animal models in studying this disease.
Dunselman
G A
GA
Department of Obstetrics and Gynecology, Academic Hospital Maastricht, The Netherlands.
Dumoulin
J C
JC
Land
J A
JA
Evers
J L
JL
D000818:Animals; D005314:Embryonic and Fetal Development; D004715:Endometriosis / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005298:Fertility; D005306:Fertilization; D007247:Infertility, Female / Q000209:etiology; D010060:Ovulation; D010534:Peritoneal Neoplasms / Q000150:complications / Q000503:physiopathology*; D011817:Rabbits