[The effect of chlorpromazine and carbamazepine on diagnostically relevant liver enzymes].
No interactions related to the analytical method were observed between chlorpromazine (1) or carbamazepine (2) and activities of alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), glutamate dehydrogenase (GLDH) or lactate dehydrogenase (LDH). With respect to its cytotoxic potential 1 in cultures of isolated rat hepatocytes increased markedly the release of enzymes into the culture medium, whereas the overall activities of the enzymes were not influenced. 2 in cultured hepatocytes caused no significant effects on the activities of the enzymes investigated. Besides the investigation of methodically related interactions in pooled human serum the methodic procedure including the use of cultures of isolated hepatocytes allows to study also pharmacologically and toxicologically related interactions between drugs and diagnostically relevant liver enzymes.
Göckeritz
W
W
Sektion Chemie, Humboldt-Universität zu Berlin.
Borchert
H H
HH
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002220:Carbamazepine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000097:blood; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002220:Carbamazepine; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002746:Chlorpromazine
Untersuchungen zur Beeinflussung labordiagnostisch relevanter Leberenzyme durch Chlorpromazin und Carbamazepin.