title: [Effects of sodium molybdate on guinea pig atria contractility].
abstract: Sodium molybdate (Mo) 10-1000 mumol/L markedly reduced the contratile force of left atria isolated from guinea pig. Mo 100 mumol/L obviously reduced the heart rates in right atria, markedly prolonged the functional refractory period from 185 +/- 12 to 245 +/- 4 ms and inhibited the resting potentiation. Mo 100 and 300 mumol/L reduced the frequency-dependent positive staircase phenomenon. However, verapamil 25 mumol/L reversed the frequency-dependent positive staircase phenomenon to negative one. The mechanism can be explained by the effect on Ca2+ movement in the heart atrium.
authors.affiliation: Research Laboratory of Electrophysiology, Xi-an Medical University, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: X G
authors.initials: XG
authors.lastname: Li
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
chemical_list: D008982:Molybdenum; C024687:sodium molybdate(VI)