title: [Paradoxical left ventricular blood flow during the isovolumic relaxation period in non-obstructive hypertrophic cardiomyopathy: Doppler and M-mode echocardiographic study].
abstract: The left ventricular blood flow pattern during the isovolumic relaxation period was investigated in 17 patients with apical hypertrophy (mean 54 +/- 8 years) and 30 with asymmetric septal hypertrophy without left ventricular outflow obstruction (mean 54 +/- 14 years). Thirty-five age-matched normal subjects served as controls (mean 51 +/- 10 years). All cases were examined by pulsed Doppler echocardiography simultaneously with phonocardiography. In all the control subjects, an apically-directed flow was observed, which occurred simultaneously with the onset of the second heart sound. In contrast, a basally-directed flow was detected during the isovolumic relaxation period in 13 patients (76%) with apical hypertrophy and in 28 (93%) with asymmetric septal hypertrophy. In these cases, an apically-directed flow was often observed before the second heart sound. Standard M-mode echocardiography revealed a significant increase in the left ventricular short-axis dimension at the base during the isovolumic period in patients with hypertrophic cardiomyopathy, while the normal controls showed no significant change. Moreover, peak velocity of the basally-directed flow correlated significantly with the rapidity of dilatation of the basal dimension (r = 0.61, p less than 0.01). Thus, this basally-directed blood flow in the left ventricle during the isovolumic relaxation period may be caused by the asynchronous left ventricular dilatation during the isovolumic period.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Shiota
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: W
authors.initials: W
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Igarashi
authors.forename: K
authors.initials: K
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D010701:Phonocardiography; D012039:Regional Blood Flow