title: Hemodynamic status during famotidine infusion.
abstract: Histamine H2 antagonists, which reduce gastric acid secretion, are often used in the intensive care setting for the prophylaxis of stress ulcers. This double-blind, placebo-controlled study evaluated hemodynamic parameters in 11 stable, critically ill patients receiving famotidine. Repeated-measures ANOVA demonstrated that famotidine had no significant effect on baseline hemodynamic measurements and that there was no significant difference in hemodynamic values following the famotidine infusion as compared with NaCl 0.9% placebo (p greater than 0.05).
authors.affiliation: Department of Critical Care Medicine, Akron General Medical Center, OH 44307.
authors.forename: D E
authors.initials: DE
authors.lastname: Heiselman
authors.forename: J
authors.initials: J
authors.lastname: Chapman
authors.forename: M
authors.initials: M
authors.lastname: Malik
authors.forename: E
authors.initials: E
authors.lastname: Riegnor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004311:Double-Blind Method; D015738:Famotidine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D015738:Famotidine