Regional alterations in the monoamine levels, monoamine oxidase activity & neurobehavioural effects in rats treated with Dimecron (phosphamidon).
Monoamine levels, MAO activity and neurobehavioral perturbations were studied in albino rats intoxicated with Dimecron i.e., phosphamidon (2.0 mg/kg b wt, ip x 7 days). Open field behaviour (OFB) of the rats was examined thrice a day for seven days. Significant depletion in DA, NE and 5-HT, and enhancement of MAO were found in various regions of the central nervous system (CNS) on the 7th day. Daily decrease was observed in ambulation, rearing and preening responses, with maximum decrement on the seventh day of Dimecron intoxication.
Naqvi
S M
SM
Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University.
Hasan
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000097:blood*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009420:Nervous System / Q000187:drug effects*; D010707:Phosphamidon / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D001679:Biogenic Amines; D010707:Phosphamidon; D008995:Monoamine Oxidase