Effects of two fluoride dentifrices containing triclosan and a copolymer on calculus formation.
A 12-week, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of two dentifrices containing triclosan (Irgacare MP) and a copolymer of methoxyethylene and maleic acid (Gantrez) as compared to a placebo dentifrice. All 147 adult male and female subjects completed the study. Subjects were stratified into three balanced groups on the basis of their Volpe-Manhold index calculus scores as obtained from a 3-month pre-test period using a placebo dentifrice. After a complete oral prophylaxis, subjects were assigned to the use of either the placebo dentifrice, a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride silica base, or a dentifrice containing 0.3% triclosan and 2.0% of a coplymer in a 0.76% sodium monofluorophosphate alumina base. Subjects, after brushing with their assigned dentifrice and soft-bristled toothbrush for 12 weeks, were evaluated by the examining dentist for supragingival calculus formation using the Volpe-Manhold assessment method. These examinations showed that the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.243% sodium fluoride silica base reduced supragingival calculus deposits by 23.12% and the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.76% sodium monofluorophosphate alumina base reduced supragingival calculus deposits by 26.15%. Both of these reductions in supragingival calculus were compared to the placebo dentifrice and were statistically significant at the 99% level of confidence.
Schiff
T
T
School of Dental Medicine, Washington University, St. Louis, Missouri.
Cohen
S
S
Volpe
A R
AR
Petrone
M E
ME
D000328:Adult; D003728:Dental Calculus / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D011145:Polyvinyls / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
D003802:Dentifrices; D004338:Drug Combinations; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan; D012969:Sodium Fluoride