Synthesis and antinociceptive activity of ring substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxypiperidines.
A series of phenyl substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxylpiperidine were synthesized and their antinociceptive activity tested in mice and compared with morphine sulphate. All compounds demonstrated antinociceptive activity in both the hot plate and the writhing tests. The studies showed that the antinociceptive activity is dependable on both the nature and the position of the substituent on the phenyl ring. Antagonism study with naloxone suggests possible interaction of the new compounds with the opioid receptors.
al-Rashood
K A
KA
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Madani
A E
AE
Ginawi
O T
OT
Ashraf
S A
SA
el-Obeid
H A
HA
D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D007540:Isonipecotic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics; D007540:Isonipecotic Acids; D009270:Naloxone