Does beta 2 adrenergic agonism affect local anaesthetic efficacy?
It is theoretically possible that adrenaline might increase local anaesthetic efficacy by a specific beta 2 adrenergic agonistic mechanism by which nerve cell membranes are hyperpolarized. This study compares the anaesthetic efficacy of a local anaesthetic containing the beta 2 adrenergic agonist salbutamol to adrenaline-containing and plain local anaesthetic solutions following intradermal injections. The findings indicate that beta 2 adrenergic agonism did not affect local anaesthetic efficacy in the model employed.
Meechan
J G
JG
Department of Oral Surgery, Dental School, University of Newcastle upon Tyne, UK.
D000420:Albuterol / Q000494:pharmacology*; D000704:Analysis of Variance; D000772:Anesthesia, Local; D004837:Epinephrine; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D010147:Pain Measurement; D011897:Random Allocation; D013997:Time Factors
D008012:Lidocaine; D000420:Albuterol; D004837:Epinephrine