Relation between myocardial histological changes and ventricular tachycardia in cardiomyopathy: a study by 24-hour ECG-monitoring and endomyocardial biopsy.
The relation between myocardial histological changes and ventricular tachycardia (VT) in cardiomyopathy was investigated. Right ventricular endomyocardial biopsy and 24-hour ECG-monitoring were performed in 19 patients with dilated cardiomyopathy (DCM) and 22 with hypertropic cardiomyopathy (HCM). Cardiomyopathy was histologically divided into the following four groups: group A, hypertrophy without disarray of myocytes (3 DCM and 7 HCM); group B, hypertrophy with disarray of myocytes (14 HCM); group C, fibrosis (9 DCM and 1 HCM); and group D, diffuse myocytic degeneration (7 DCM). VT was observed in 20% (2 of 10 patients) of group A, 14% (2 of 14) of group B, 80% (8 of 10) of group C, and 71% (5 of 7) of group D. The degenerating myocytes and/or the irregular distribution of fibrosis may play an important role in the etiology of VT in cardiomyopathy.
Segawa
I
I
Department of Internal Medicine, Iwate Medical University, School of Medicine, Morioka, Japan.
Suzuki
T
T
Kato
M
M
Tashiro
A
A
Satodate
R
R
D000328:Adult; D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000473:pathology* / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D004699:Endocardium / Q000473:pathology* / Q000503:physiopathology; D004719:Endomyocardial Fibrosis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013610:Tachycardia / Q000473:pathology* / Q000503:physiopathology