The syndrome of hypertension and hyperkalaemia with normal glomerular filtration rate: is there a deficiency in vasodilator prostaglandins?
1. In Gordon's syndrome (GS; a syndrome of hypertension and hyperkalaemia with normal glomerular filtration rate), excessive proximal sodium reabsorption leads to suppression of renin and aldosterone, hyperkalaemia and hyperchloraemic acidosis. 2. Low urinary levels of vasodilator prostaglandins (PG) have been reported in GS, suggesting renal hypoprostaglandinism as a pathophysiological mechanism. 3. In four cases of GS, levels of vasodilator prostaglandins PGE2 and 6-keto-PGF1 alpha were low. 4. In one case of GS, low PGE2 levels were normalized by dietary salt restriction or diuretic therapy.
Klemm
S A
SA
Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.
Hornych
A
A
Tunny
T J
TJ
Gordon
R D
RD
D000328:Adult; D002648:Child; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005192:Family Health; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D006947:Hyperkalemia / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D011453:Prostaglandins / Q000172:deficiency* / Q000652:urine; D012982:Sodium, Dietary / Q000494:pharmacology; D013577:Syndrome
D011453:Prostaglandins; D012982:Sodium, Dietary; D015237:Dinoprost; D015232:Dinoprostone