Apoptosis in pancreatic allograft rejection--ultrastructural observations.
Transplantation of pancreaticoduodenal allografts in the PVG.RT1c----PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.
Knoop
M
M
Immunology Group, University of Manchester, UK.
McMahon
R F
RF
Jones
C J
CJ
Hutchinson
I V
IV
D000818:Animals; D002470:Cell Survival; D006084:Graft Rejection; D008264:Macrophages / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes / Q000473:pathology / Q000648:ultrastructure; D010179:Pancreas / Q000473:pathology* / Q000648:ultrastructure; D016035:Pancreas Transplantation / Q000473:pathology*; D051381:Rats; D014184:Transplantation, Homologous