title: [Interrelationship between the Bcg and Tbc-1 genes].
abstract: The relationship of the mouse Bcg and Tbc-1 genes was studied. It was shown that the F1 hybrids between highly susceptible to tuberculosis mice I/St (Tbc-1s) and the Bcgs-carrying strains were highly resistant to M. tuberculosis H37Rv infection. These results point to complementation of Bcgs and Tbc-1s genes. Analysis of survival time of the [(AKR x B10-fzy)F1 x B10-Fzy]BC1 offspring showed that the mouse chromosome 1 does not regulate resistance to H37Rv infection. No linkage of the Tbc-1s gene with chromosome 1 was revealed when using fzy gene as a marker of the chromosome 1.
authors.forename: B V
authors.initials: BV
authors.lastname: Nikonenko
authors.forename: A S
authors.initials: AS
authors.lastname: Apt
authors.forename: M B
authors.initials: MB
authors.lastname: Mezhlumova
authors.forename: A M
authors.initials: AM
authors.lastname: Moroz
mesh_terms: D000818:Animals; D005816:Genetic Complementation Test; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D014376:Tuberculosis / Q000235:genetics*
vernacular_title: Geny Bcg i Tbc-1, vzaimosviaz'.