title: Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia.
abstract: From May 1980 to December 1989, 107 consecutive patients with non-constitutional severe aplastic anemia underwent bone marrow transplantation at our institution using cyclophosphamide and thoraco-abdominal irradiation as conditioning regimen. During the same period, 40 patients with Fanconi anemia were also grafted after a similar conditioning, giving a total series of 147 patients. With a mean follow-up of 64 months, four male patients developed a solid malignant tumor, a number that leads to an 8-year cumulative incidence rate of 22% (eg, relative risk to general population = 41, P less than .001). These results should be considered as a warning to clinicians who follow these successfully grafted long-term patients.
authors.affiliation: Bone Marrow Transplant Unit, Hôpital Saint-Louis, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Socié
authors.forename: M
authors.initials: M
authors.lastname: Henry-Amar
authors.forename: J M
authors.initials: JM
authors.lastname: Cosset
authors.forename: A
authors.initials: A
authors.lastname: Devergie
authors.forename: T
authors.initials: T
authors.lastname: Girinsky
authors.forename: E
authors.initials: E
authors.lastname: Gluckman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005199:Fanconi Anemia / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies