title: [The distribution of solutions in the epidural space].
abstract: In 21 patients the distribution within the epidural space of epidurally injected 99mTc-DTPA was assessed. The gamma emissions from the epidural space were measured externally with the patients in supine position by use of a gamma camera. The recordings over the patient's back were stored in digital computer for 60 min. The results were as follows; 1) The spread of the radionuclide was mainly to cephalad direction, and seldom crossed the L5 level to sacral region. 2) The solution injected in the epidural space would distribute to less resistant compartments and the spread depends on the power of injection, negative pressure in the high epidural space and capillary pressure. 3) The elimination half-life of the injected radionuclide was between 1 to 17 min depending on the region in the epidural space. 4) The solution injected in the epidural space may penetrate dura mater at the ink cuff area and local anesthetic agents may affect the spinal nerve roots in the subarachnoid space rather than at the extra-dural space. 5) With continuous infusion technique the diffusion and penetration of the local agent through the dura mater are facilitated and more profound anesthetic effects would be expected. In clinical practice the utilization of the continuous infusion method should be considered along with the bolus injection.
authors.affiliation: Department of Anesthesiology, Hakuji-kai Memorial Hospital, Tokyo.
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Fujimaki
authors.forename: M
authors.initials: M
authors.lastname: Oshibuchi
authors.forename: I
authors.initials: I
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Aida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural; D000777:Anesthetics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004824:Epidural Space; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016284:Technetium Tc 99m Pentetate
chemical_list: D000777:Anesthetics; D016284:Technetium Tc 99m Pentetate