[Effects of the combination of aspirin and nifedipine on platelet aggregation and thrombogenesis].
The effects of nifedipine (Nif), aspirin (ASA) and ASA + Nif on platelet aggregation and generation of thrombosis were studied. Both ASA and Nif inhibited rabbit platelet aggregation in vitro and rat platelet aggregation in vivo induced by ADP, also prolonged the occlusion time of thrombosis induced electrically in the carotid artery of the rat and reduced the death rate resulting from pulmonary thrombosis induced by i.v collagen and epinephrine in mice. The above effects were markedly increased when Nif and ASA were used in combination. All the above effects were dose-dependent.
Dong
E
E
Shi Shan Laboratory of Cardiovascular Research, Baotou Medical College.
Shi
S
S
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*
D010975:Platelet Aggregation Inhibitors; D009543:Nifedipine; D001241:Aspirin