title: Hemostatic studies in patients with infective endocarditis: a report on nine consecutive cases with evidence of coagulopathy.
abstract: Local and generalized changes in coagulation may be important in the genesis of vegetations and embolism in infective endocarditis. To characterize such alterations, serial hematological investigations were performed on nine consecutive patients who satisfied the inclusion criteria. Platelet survival was measured by Indium111 labeling. Acute and convalescent samples were analyzed for fibrinogen, factor VIIIc, antithrombin III (AT III), fibrin/fibrinogen degradation products (FDPs), and platelet aggregation. The results suggest that in the active stage of the disease: (1) hypercoagulability may be caused by a rise in acute phase reactants, (2) an acceleration of coagulation and fibrinolysis may supervene, and (3) in some cases there is a reduction in platelet aggregation, possibly as a result of continued circulation of previously activated "exhausted" platelets.
authors.affiliation: Department of Medicine (Clinical Cardiology and Haematology Units), Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Taha
authors.forename: S
authors.initials: S
authors.lastname: Durrant
authors.forename: J
authors.initials: J
authors.lastname: Crick
authors.forename: S
authors.initials: S
authors.lastname: Bowcock
authors.forename: A
authors.initials: A
authors.lastname: Bradshaw
authors.forename: C M
authors.initials: CM
authors.lastname: Oakley
mesh_terms: D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000378:metabolism*; D004697:Endocarditis, Bacterial / Q000097:blood*; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology; D010979:Platelet Function Tests; D013290:Streptococcal Infections / Q000097:blood*; D013927:Thrombosis / Q000097:blood
chemical_list: D001779:Blood Coagulation Factors