Oxygen derived free radicals and the course of Eimeria vermiformis infection in inbred strains of mice.
Free radical generation by peritoneal leukocytes from BALB/c and C57BL/6 mice was monitored for 18 days following infection with Eimeria vermiformis. Free radical generation occurred earlier and was quantitatively much greater in resistant BALB/c mice than in susceptible C57BL/6 mice, resistance being indicated by a much lower oocyst production and a shorter patent period of E. vermiformis. Plasma greatly enhanced free radical generation in response to a soluble antigen prepared from sporulated oocysts indicating the presence of plasma-borne factor(s) which enhance free radical generation in response to E. vermiformis.
Ovington
K S
KS
Department of Zoology, Australian National University, Canberra.
Smith
N C
NC
Joysey
H S
HS
D000818:Animals; D003048:Coccidiosis / Q000276:immunology / Q000378:metabolism*; D004198:Disease Susceptibility; D005260:Female; D005609:Free Radicals; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism; D008165:Luminol; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010100:Oxygen / Q000378:metabolism*; D010270:Parasite Egg Count; D010529:Peritoneal Cavity / Q000166:cytology; D011897:Random Allocation; D013045:Species Specificity
D005609:Free Radicals; D008165:Luminol; D010100:Oxygen