[Measurement of nuclear DNA content of laryngeal carcinoma and determination of estrogen receptor (ER) level in laryngeal cancer cells].
In 39 patients with laryngeal carcinoma, nuclear DNA content was measured, and the ER in cancer cells of 23 cases determined. The following results were obtained: 1. For all laryngeal carcinomas, there were two patterns-diploid and non-diploid carcinomas. The majority (27/39) belonged to the non-diploid pattern. 2. The laryngeal carcinomas of non-diploid pattern or with higher level of DNA content were easily metastasized to cervical nodes. This kind of cancers were more often seen in clinically advanced cases. Patients with these carcinomas, judged by the results of one-year's follow-up, had poor prognosis. 3. Carcinomas with diploid pattern or with lower level of DNA content had the tendency to become ER positive. The cervical node metastases was more easily taking place in ER negative carcinomas. Some indirect relationship between DNA content and ER in laryngeal cancers may exist.
Lin
S
S
1st Affiliated Hospital, Jiang Medical University, Hangzhou.
D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*
D004273:DNA, Neoplasm; D011960:Receptors, Estrogen