[Interrelationship between the Bcg and Tbc-1 genes].
The relationship of the mouse Bcg and Tbc-1 genes was studied. It was shown that the F1 hybrids between highly susceptible to tuberculosis mice I/St (Tbc-1s) and the Bcgs-carrying strains were highly resistant to M. tuberculosis H37Rv infection. These results point to complementation of Bcgs and Tbc-1s genes. Analysis of survival time of the [(AKR x B10-fzy)F1 x B10-Fzy]BC1 offspring showed that the mouse chromosome 1 does not regulate resistance to H37Rv infection. No linkage of the Tbc-1s gene with chromosome 1 was revealed when using fzy gene as a marker of the chromosome 1.
Nikonenko
B V
BV
Apt
A S
AS
Mezhlumova
M B
MB
Moroz
A M
AM
D000818:Animals; D005816:Genetic Complementation Test; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D014376:Tuberculosis / Q000235:genetics*
Geny Bcg i Tbc-1, vzaimosviaz'.