Acute autonomic neuropathy associated with a high serum bradykinin level and positive anti-nuclear and anti-DNA antibodies titers.
A hypotensive 37-year-old man developed the problems of impotence, lack of sweating, orthostatic hypotension, and convulsive syncopal attack. His blood pressure fell to 53 mmHg systolic following bed-tilting from 30 to 60 degrees, but his heart rate remained constant which indicated a diagnosis of acute autonomic neuropathy. With the tilting test, a decrease in serum catecholamine levels and an increase in bradykinin levels were observed. Four months after admission, anti-nuclear antibody, anti-DNA antibody, and the LE test became positive. The acute autonomic neuropathy appeared to be associated with SLE, and the hyperbradykinism, consequent on orthostatic hypotension.
Otokida
K
K
Second Department of Internal Medicine, Iwate Medical University School of Medicine, Japan.
Yoshida
H
H
Sato
N
N
Kutsuzawa
S
S
Isagozawa
S
S
Yamada
M
M
Kato
M
M
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001920:Bradykinin / Q000097:blood*; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D007007:Hypohidrosis / Q000209:etiology; D007024:Hypotension, Orthostatic / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008297:Male; D013575:Syncope / Q000209:etiology
D000974:Antibodies, Antinuclear; D001920:Bradykinin