High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.
A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.
Vree
T B
TB
Department of Clinical Pharmacy, University Hospital Nijmegen Saint Radboud, The Netherlands.
Beneken Kolmer
E W
EW
Hekster
Y A
YA
D000107:Acetylation; D002851:Chromatography, High Pressure Liquid; D005965:Glucuronates / Q000378:metabolism; D005966:Glucuronidase; D006207:Half-Life; D006801:Humans; D008297:Male; D010641:Phenotype; D011485:Protein Binding; D013426:Sulfaphenazole / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D005965:Glucuronates; D013426:Sulfaphenazole; C068641:sulfaphenazole-N2-glucuronide; C068642:N4-acetylsulfaphenazole; D005966:Glucuronidase