title: Decontamination of the bowel by intravenous administration of pefloxacin.
abstract: Intravenous administration of pefloxacin 400 mg twice daily rapidly decontaminated the bowel from Gram-negative bacilli in ten healthy volunteers. The faecal concentrations of enterococci and yeasts did not change significantly. Further, pefloxacin did not facilitate colonization of the bowel by a highly resistant challenge strain (Klebsiella pneumoniae, MIC = 56 mg/l). The diffusible faecal concentration of pefloxacin was between 110 and 260 mg/l in all samples from day 3 of treatment onwards. It is concluded that parenteral administration of pefloxacin is very effective for decontamination of the bowel from Gram-negative bacilli and provides reliable prophylaxis against colonization of the bowel by highly resistant Gram-negative bacilli ingested with food.
authors.affiliation: Department of Pharmacy, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: Vollaard
authors.forename: H A
authors.initials: HA
authors.lastname: Clasener
authors.forename: A J
authors.initials: AJ
authors.lastname: Janssen
mesh_terms: D000328:Adult; D001419:Bacteria / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015366:Pefloxacin / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects
chemical_list: D015366:Pefloxacin