Enhancement of in-vitro activity of ofloxacin and gentamicin by rat serum.
Normal rat serum shows antibacterial activity because of the presence of endogenous substances. The aim of this research was to study some aspects of the interaction between this biological fluid and some antibiotics, in order to demonstrate possible synergistic activity. Serum is able to lower the minimum inhibitory concentration of gentamicin and ofloxacin against some Gram-negative microorganisms. This can be explained by the presence of lysozyme, antibodies, beta-lysin and other complementary factors that are able to cooperate with these antibiotics.
Miglioli
P A
PA
Dept. of Pharmacology, Padova, Italy.
Pea
F
F
Zatti
V
V
D000818:Animals; D001770:Blood Bactericidal Activity; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D009343:Neisseria / Q000187:drug effects; D015242:Ofloxacin / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects; D051381:Rats
D005839:Gentamicins; D015242:Ofloxacin