Beneficial effect of dexamethasone on attenuated hormone-induced uptake of calcium and glycogenolysis by perfused liver of rats infected with Fasciola hepatica.
Infection of rats with the liver fluke, Fasciola hepatica, impaired the responses of the perfused liver to calcium uptake and glucose release induced by the synergistic action of glucagon and vasopressin. Treatment of infected rats with dexamethasone prevented the impairment of each of these two responses.
Hanisch
M J
MJ
Division of Biochemistry and Molecular Biology, School of Life Sciences, Australian National University, Canberra.
Behm
C A
CA
Bygrave
F L
FL
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D004357:Drug Synergism; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D003907:Dexamethasone; D006003:Glycogen; D005934:Glucagon; D005947:Glucose; D002118:Calcium