Antigen-specific immunodepression induced by doxorubicin-BSA conjugate in mice.
Injection into mice of the anthracycline cytotoxic derivative Doxorubicin (DXR) covalently bound to bovine serum albumin (BSA) was associated with antigen-specific depression of the primary (but not of the secondary) antibody reaction to the carrier, whereas DXR and BSA injected in the form of a mixture caused no such effect. Tetanus toxoid completely prevented the carrier-specific inhibiting effect when administered at the same time as, but not three days before or after, injection of the DXR-BSA conjugate. Possible mechanisms of the antigen-specific immunodepression and its prevention by unrelated antigen are discussed.
Balsari
A
A
Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.
Cerofolini
M
M
Ghione
M
M
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens; D004317:Doxorubicin / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents; D008262:Macrophage Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000494:pharmacology*; D013745:Tetanus Toxoid / Q000276:immunology
D000941:Antigens; D007166:Immunosuppressive Agents; D013745:Tetanus Toxoid; C069982:doxorubicin-BSA conjugate; D012710:Serum Albumin, Bovine; D004317:Doxorubicin