title: Computer simulation for optimization of high-performance liquid chromatography of some phenolic pollutants.
abstract: Computer simulation was used to optimize high-performance liquid chromatography of phenol and its chloro and nitro derivatives. On the basis of two linear gradient runs of different steepness (RP-18-water + methanol + 1% acetic acid), several simulated gradient runs allowed the optimum gradient programme and flow-rate to be chosen so that the time of analysis could be considerably shortened. Good agreement between simulated and experimental chromatograms was obtained in spite of changes in experimental conditions.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Medical Academy, Lublin, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Markowski
authors.forename: T H
authors.initials: TH
authors.lastname: Dzido
authors.forename: E
authors.initials: E
authors.lastname: Soczewiński
mesh_terms: D000393:Air Pollutants / Q000032:analysis; D002733:Chlorophenols / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003198:Computer Simulation; D009596:Nitrophenols / Q000032:analysis; D010636:Phenols / Q000032:analysis*; D014873:Water Pollutants / Q000032:analysis
chemical_list: D000393:Air Pollutants; D002733:Chlorophenols; D009596:Nitrophenols; D010636:Phenols; D014873:Water Pollutants