[Activation of the complement system of plasma and the changes in various parameters of homeostasis in rats after intravenous administration of emulsion of organoperfluorine compounds].
Anticomplementary activity of emulsion based on the organoperfluorine compounds (PFC) perfluorodecalin and perfluorotripropylamine (7:3) has been shown in vitro. A temporary reduction of the neutrophil number up to 25% of the initial level was recorded 5 min after intravenous plethoric administration of 1.0 ml of this emulsion to rats. A drop in the arterial pressure and blood minute volume was observed in half of the animals, 30 and 60 min later impairment of the body oxygen regimen resulting in tissue hypoxia was recorded in all the rats. It has been suggested that the disorders observed in the animals are caused by the action of varying mediators produced due to the intravascular activation of the complement by PFC.
Dolgushina
A D
AD
Berkos
M V
MV
Piatovskaia
N N
NN
Kochetygov
N I
NI
Sedova
L A
LA
D000818:Animals; D003167:Complement Activation / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D007022:Hypotension / Q000139:chemically induced*; D000860:Hypoxia / Q000139:chemically induced*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D004655:Emulsions; D005466:Fluorocarbons; C039422:perfluorotripropylamine; C008805:perfluorodecalin
Aktivatsiia sistemy komplementa plazmy krovi i izmenenie nokotorykh parametrov gomeostaza posle vnutrivennogo vvedeniia krysam émul'sii perftororganicheskikh soedineniĭ.