title: Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E.
abstract: The relationship between the antioxidant effects of reduced coenzyme Q10 (ubiquinol, UQH2) and vitamin E (alpha-tocopherol) was investigated in beef heart submitochondrial particles in which lipid peroxidation was initiated by incubation with ascorbate + ADP-Fe3+. These effects were examined after extraction of coenzyme Q10 (UQ-10) and vitamin E from the particles and reincorporation of the same components alone or in combination. The results show that UQH2 efficiently inhibits lipid peroxidation even when vitamin E is absent. It is concluded that UQH2 can inhibit lipid peroxidation directly, without the mediation of vitamin E.
authors.affiliation: Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Forsmark
authors.forename: F
authors.initials: F
authors.lastname: Aberg
authors.forename: B
authors.initials: B
authors.lastname: Norling
authors.forename: K
authors.initials: K
authors.lastname: Nordenbrand
authors.forename: G
authors.initials: G
authors.lastname: Dallner
authors.forename: L
authors.initials: L
authors.lastname: Ernster
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants; D001205:Ascorbic Acid / Q000378:metabolism; D002417:Cattle; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008929:Mitochondria, Heart; D009097:Multienzyme Complexes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013367:Submitochondrial Particles / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology* / Q000031:analogs & derivatives; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D009097:Multienzyme Complexes; D014451:Ubiquinone; D014810:Vitamin E; D000244:Adenosine Diphosphate; D007501:Iron; D010088:Oxidoreductases; C022691:succinate oxidase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; C003741:ubiquinol; D001205:Ascorbic Acid