title: Apoptosis in pancreatic allograft rejection--ultrastructural observations.
abstract: Transplantation of pancreaticoduodenal allografts in the PVG.RT1c----PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.
authors.affiliation: Immunology Group, University of Manchester, UK.
authors.forename: M
authors.initials: M
authors.lastname: Knoop
authors.forename: R F
authors.initials: RF
authors.lastname: McMahon
authors.forename: C J
authors.initials: CJ
authors.lastname: Jones
authors.forename: I V
authors.initials: IV
authors.lastname: Hutchinson
mesh_terms: D000818:Animals; D002470:Cell Survival; D006084:Graft Rejection; D008264:Macrophages / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes / Q000473:pathology / Q000648:ultrastructure; D010179:Pancreas / Q000473:pathology* / Q000648:ultrastructure; D016035:Pancreas Transplantation / Q000473:pathology*; D051381:Rats; D014184:Transplantation, Homologous