[Synthesis of analogs of cephalotaxine esters and their antitumor activities].
Four analogs of cephalotaxine esters (C1Z, C2E, C3E, C4E) were synthesized. The ratio of the Z, E isomers of the side chain alpha, beta-unsaturated ester carboxylic acids is reported. The Z isomer was easy to transform to the E isomer. Compound C1Z showed significant activity of inducing cancer cell HL-60 differentiation. It also showed inhibitory activity on Leukemia L1210.
Wei
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Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Jiang
Y Z
YZ
Zhao
Z Z
ZZ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D006248:Harringtonines / Q000138:chemical synthesis / Q000494:pharmacology; D000077863:Homoharringtonine; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D006248:Harringtonines; D000077863:Homoharringtonine