title: A clinical comparison of bone imaging agents.
abstract: This study compares the six commercially available kits for preparing methylene diphosphonate. The kits were randomly assigned to 134 bone examinations such that neither the physicians nor the technologists knew which brand of tracer was used. Thigh activity quantitatively varied significantly among the kits (P = 0.019). Detectable gastric activity also varied by brand. Other qualitative and quantitative measures of bone and soft tissue uptake showed no significant differences among the kits but consistently favored the Squibb product.
authors.affiliation: Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
authors.forename: T R
authors.initials: TR
authors.lastname: Simon
authors.forename: J A
authors.initials: JA
authors.lastname: Carrasquillo
authors.forename: R
authors.initials: R
authors.lastname: Fejka
authors.forename: M
authors.initials: M
authors.lastname: Der
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D005069:Evaluation Studies as Topic; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D011933:Reagent Kits, Diagnostic; D013669:Technetium Tc 99m Medronate