title: Cytotoxicity on L1210 leukemic cells of beta-amanitin-concanavalin A and phallacidin-concanavalin A conjugates.
abstract: The conjugates beta-amanitin-concanavalin A and phallacidin concanavalin A were tested for direct cytotoxicity on L1210 lymphocytic leukemia cells by a combined in vitro-in vivo bioassay. Both conjugates exerted strong direct cytotoxicity on the tumour cells.
authors.affiliation: University School of Medicine, Department of Biology, Stara Zagora, Bulgaria.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhelev
authors.forename: M
authors.initials: M
authors.lastname: Ilarionova
authors.forename: A
authors.initials: A
authors.lastname: Zheleva
authors.forename: C
authors.initials: C
authors.lastname: Alexiev
authors.forename: K
authors.initials: K
authors.lastname: Halacheva
authors.forename: D
authors.initials: D
authors.lastname: Todorov
mesh_terms: D000546:Amanitins / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival; D003208:Concanavalin A; D003603:Cytotoxins / Q000633:toxicity*; D000922:Immunotoxins; D007939:Leukemia L1210; D010456:Peptides, Cyclic / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D000546:Amanitins; D003603:Cytotoxins; D000922:Immunotoxins; D010456:Peptides, Cyclic; D003208:Concanavalin A; C049197:beta-amanitin; C017613:phallacidin