Plasma serotonergic activation in rats during the course of experimental allergic neuritis.
The plasma serotonin (5-HT) levels in Lewis rats were measured during the course of experimental allergic neuritis (EAN) induced by use of purified bovine myelin. The plasma 5-HT levels in EAN rats were significantly higher than those in control rats 15 days (day 15) and 20 days (day 20) after the inoculation. On day 15 and day 20, the 5-hydroxytryptophan levels in the EAN rats were higher than those in the control rats. It is suggested that 5-HT plays a role in the clinical course of EAN.
Shimomura
T
T
Division of Neurology, Tottori University School of Medicine, Yonago, Japan.
Tanaka
H
H
Takahashi
K
K
D006916:5-Hydroxytryptophan / Q000097:blood; D000818:Animals; D005260:Female; D009444:Neuritis, Autoimmune, Experimental / Q000097:blood*; D051381:Rats; D011917:Rats, Inbred Lew; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D006916:5-Hydroxytryptophan