Modulation of guinea pig airway reactivity by the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE).
The influence of the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE) on guinea pig tracheal reactivity to both contractile and relaxant agonists was investigated in vitro. 13-HODE induced an increased contraction of tracheal rings to histamine, whereas methacholine responsiveness was not significantly affected. Relaxant responses to isoprenaline and prostaglandin E2 were not influenced either.
Engels
F
F
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Henricks
P A
PA
van der Linde
H J
HJ
Nijkamp
F P
FP
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008041:Linoleic Acids / Q000494:pharmacology*; D009119:Muscle Contraction; D014132:Trachea / Q000187:drug effects*
D008041:Linoleic Acids; C024348:13-hydroxy-9,11-octadecadienoic acid; D006632:Histamine