title: Novel system for percutaneous cardiopulmonary bypass.
abstract: Percutaneous cardiopulmonary bypass (PCPB) has recently come to the forefront of medicine as a technique for resuscitating and supporting patients in various clinical situations. Current systems utilize small-diameter cannulas to aspirate blood under high suction into the cardiopulmonary bypass circuit. Aspiration-based systems have several disadvantages including risk of air embolism, blood hemolysis, and cavitation. Additionally, they are suboptimal for use during open-heart surgical procedures. A system with a venous cannula that employs gravity drainage has been evaluated. Once advanced into position over a guide-wire, the stylet is removed, causing the basket near the end of the cannula to expand. Blood flows into the cannula from side holes and the basket region, which prevents the vessel wall or atrium from collapsing around the catheter and impeding venous drainage. Hemodynamic, hematologic, and histologic examinations were performed on eight anesthetized mongrel dogs during 2 h of PCPB. All animals exhibited adequate tissue perfusion and right and left heart decompression. All animals were successfully weaned from PCPB and after 30 min exhibited normal myocardial function. No ischemic changes were observed in the heart, lung, kidney, or liver by light and electron microscopy. We conclude that full PCPB can be satisfactorily achieved by using a novel percutaneous venous cannula and gravity drainage.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Deborah Heart and Lung Center, Browns Mills, NJ 08015.
authors.forename: G W
authors.initials: GW
authors.lastname: Laub
authors.forename: S
authors.initials: S
authors.lastname: Muralidharan
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: S B
authors.initials: SB
authors.lastname: Pollock
authors.forename: A
authors.initials: A
authors.lastname: Perritt
authors.forename: C
authors.initials: C
authors.lastname: Daloisio
authors.forename: M
authors.initials: M
authors.lastname: Adkins
authors.forename: L B
authors.initials: LB
authors.lastname: McGrath
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002404:Catheterization; D003326:Coronary Circulation / Q000502:physiology; D004285:Dogs; D010477:Perfusion