[Effect of structure of hapten carrying model substances on contact reaction: DNP conjugates of stereoisomers of alpha-alanine following DNCB sensitization].
By means of epicutaneous tests under standard conditions we studied the cell-mediated contact sensitivity to dinitrophenyl (DNP) conjugates of the stereoisomeric amino acids L-alpha-alanine and D-alpha-alanine, respectively, in patients sensitized with dinitrochlorobenzene (DNCB). There was no difference in the number of positive skin responses with the two enantiomeric compounds DNP-L-alpha-alanine (16/26) and DNP-D-alpha-alanine (17/26). However, as in earlier studies, no patient has shown a positive reaction to the position-isomeric DNP-beta-alanine.
Schwartze
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Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Martin-Luther-Universität Halle, Wittenberg.
Lübbe
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D000409:Alanine / Q000276:immunology*; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology*; D004137:Dinitrochlorobenzene; D005260:Female; D006241:Haptens / Q000276:immunology*; D006801:Humans; D008297:Male; D010328:Patch Tests; D013329:Structure-Activity Relationship
D004136:Dinitrobenzenes; D004137:Dinitrochlorobenzene; D006241:Haptens; D000409:Alanine
Der Einfluss der Struktur haptentragender Modellsubstanzen auf die Kontaktreaktion: DNP-Konjugate der Stereoisomeren des alpha-Alanins nach DNCB-Sensibilisierung.