title: Current techniques for infrainguinal arterial reconstruction.
abstract: Infrainguinal reconstruction for peripheral vascular occlusive disease comprises an increasingly complex array of interventions which provide unparalleled options for the salvage of threatened limbs. Conventional autogenous saphenous vein bypass remains the most durable revascularization with anticipated graft patency rates approaching 80 percent after five years and excellent long term limb salvage. These excellent results are equally applicable to vein grafts carried to infrapopliteal and even inframalleolar levels, possibly reflecting increased utilization of the in situ method. Although 20 per cent of grafts fail within five years, secondary intervention results in sustained limb salvage in the majority of patients. In the absence of autogenous vein, however, prosthetic material performs poorly such that new interventions consisting of percutaneous transluminal angioplasty, rotary atherectomy devices and laser systems are under aggressive development. Although initial results with these devices are encouraging, long term patency rates remain poor largely due to restenosis. Further progress seems to depend primarily on an increased understanding of the natural healing response of the injured artery.
authors.affiliation: Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: A
authors.initials: A
authors.lastname: Whittemore
mesh_terms: D016342:Angioplasty, Laser; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D001807:Blood Vessel Prosthesis; D006083:Graft Occlusion, Vascular / Q000453:epidemiology; D006801:Humans; D007866:Leg / Q000098:blood supply*; D011138:Polytetrafluoroethylene; D012008:Recurrence; D012501:Saphenous Vein / Q000637:transplantation
chemical_list: D011138:Polytetrafluoroethylene