title: [Antiprolifirative effect of chlorbutin and sensitivity of patients with glomerulonephritis to this drug].
abstract: Children suffering from different forms of glomerulonephritis were examined for the sensitivity of peripheral blood lymphocytes to the antiproliferative action of chlorambucil in vitro. All the patients were given chlorambucil treatment in accordance with a 4-component scheme. As a result, in 15 patients (group I), a complete clinicolaboratory remission was attained. In 8 patients, (group II), the treatment results were estimated as a partial remission and in 8 patients (group III), the treatment turned out ineffective. In 14 patients of group I, the sensitivity of peripheral blood lymphocytes to the antiproliferative action of chlorambucil was viewed as high whereas in 7 patients of group III as low. Peripheral blood lymphocytes from group II patients had a low sensitivity to chlorambucil. The prognostic value of the laboratory test suggested is under discussion.
authors.forename: A L
authors.initials: AL
authors.lastname: Pukhal'skiĭ
authors.forename: A P
authors.initials: AP
authors.lastname: Toptygina
authors.forename: O E
authors.initials: OE
authors.lastname: Dolomanova
authors.forename: V I
authors.initials: VI
authors.lastname: Naumova
authors.forename: N A
authors.initials: NA
authors.lastname: Torubarova
mesh_terms: D000293:Adolescent; D000328:Adult; D000477:Alkylating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D002699:Chlorambucil / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male
chemical_list: D000477:Alkylating Agents; D007166:Immunosuppressive Agents; D002699:Chlorambucil
vernacular_title: Antiproliferativnoe deĭstvie khlorbutina i chuvstvitel'nost' bol'nykh glomerulonefritom k terapii etim preparatom.