title: Tectorial membrane changes in hypothyroid rats during postnatal development.
abstract: The morphological changes of the tectorial membrane (TM) during the postnatal development (0, 3, 6, 12 and 25 day old) of the organ of Corti were studied by light microscopy in 20 control and hypothyroid rats. Hypothyroidism was induced by daily administration of propylthioruracil (PTU) until the end of lactation. The auditive receptor in the cochlea of the hypothyroid animals shows serious structural alterations compared with those of normal ones: abnormal persistence of Kölliker's organ, immaturity of sensory cells and supporting cells and a specific distortion of the TM. Differences with controls were first observed on the sixth postnatal day of the hypothyroid rats. The inner spiral sulcus was not shaped and the TM was attached to the Kölliker's organ. In older stages (12 and 25 days), Kölliker's organ was still present. The TM acquired a shap hump with an abnormal fibrillar arrangement in its middle part. It was still attached to the outer supporting cells by a remnant of the marginal net. It was suggested that the TM is secreted by the inner spiral limbus and Kölliker's organ. An abnormal persistence of these structures in the hypothyroidism results in a retardation of Corti's organ development. However, this conclusion does not explain the absence of the outer portion of the TM. Our study confirms the hypothesis that the secretion of any components of the marginal zone of TM is made by outer supporting cells which in PTU-treated animals appear very immature and with hypoplasia.
authors.affiliation: Department of Anatomy, University of Alicante, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pujante
authors.forename: M L
authors.initials: ML
authors.lastname: Sala
authors.forename: A
authors.initials: A
authors.lastname: Angulo
mesh_terms: D000818:Animals; D005260:Female; D007037:Hypothyroidism / Q000473:pathology*; D009925:Organ of Corti / Q000254:growth & development / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013680:Tectorial Membrane / Q000254:growth & development / Q000473:pathology*