[Possible mechanism of regulation of the bile-secretory function of the liver by hydrocortisone].
Hydrocortisone has been studied for its effect on the bile secretion in rat under normal conditions and malfunction of hormonal induction mechanisms due to specific inhibitors of protein synthesis by actinomycin D, cycloheximide and puromycin. The character of changes in bile flow rate, observed as a response to hydrocortisone injection, depends on the intensity of transcription and translation processes in the rat liver cells.
Masiuk
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AI
Dolgova
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EN
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004347:Drug Interactions; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D006854:Hydrocortisone
Vozmozhnyĭ mekhanizm reguliatsii zhelcheotdelitel'noĭ funktsii pecheni gidrokortizonom.