[Clinical value of studying phospholipids in young children with acute pneumonia].
A study was made of phospholipid metabolism in 268 children aged 1 month to 3 years, who were in a critical condition consequent on acute complicated pneumonia. Unbalance of that type metabolism was revealed. It consisted in intensive accumulation of lysophosphatidylcholine, sphingomyelin in the stroma of red blood cells and in a decrease of their pool in the blood plasma as well as in a reduction of the content of phosphatidylserine and phosphatidylethanolamine towards the plasma pool. The bronchial secretion was established to have an elevated content of malonic dialdehyde, diene conjugates and active phospholipases. The indicated membrane destabilizing processes occurring in patients with acute complicated pneumonia, who are in urgent conditions, dictate the necessity of including antioxidants and membrane stabilizers into the multimodality treatment of the disease.
Sultanov
A T
AT
Shamsiev
F S
FS
Krylov
V I
VI
Shermatov
K S
KS
Alimov
A V
AV
Fishelev
G I
GI
D000208:Acute Disease; D002675:Child, Preschool; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism*; D011014:Pneumonia / Q000150:complications / Q000378:metabolism*; D012131:Respiratory Insufficiency / Q000209:etiology; D013183:Sputum / Q000378:metabolism*
D010743:Phospholipids
Klinicheskoe znachenie issledovaniia fosfolipidov pri ostroĭ tiazhelo protekaiushcheĭ pnevmonii u deteĭ rannego vozrasta.