title: Michaelis-Menten pharmacokinetics of phenytoin in adult Malaysian patients.
abstract: We reviewed our data from 122 records of patients taking phenytoin for the treatment of various types of epilepsy and selected 15 (age range 10-43 years old) who were on phenytoin alone to calculate Michaelis-Menten pharmacokinetic parameters. The average Vm and Km for this age group was found to be 8.45 mg/kg/day and 6.72 mg/litre, respectively. Km was independent of age and weight. Vm correlated well with weight but there was no relationship with age.
authors.affiliation: Therapeutic Drug Monitoring Services, Hospital USM, Kubang Kerian, Kelantan, Malaysia.
authors.forename: R
authors.initials: R
authors.lastname: Ismail
authors.forename: A F
authors.initials: AF
authors.lastname: Rahman
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D010672:Phenytoin / Q000493:pharmacokinetics*; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D010672:Phenytoin