Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells.
The ability of eukaryotic organisms of the same genotype to vary in developmental pattern or in phenotype according to varying environmental conditions is frequently associated with changes in extrachromosomal circular DNA (eccDNA) sequences. Although variable in size, sequence complexity, and copy number, the best characterized of these eccDNAs contain sequences homologous to chromosomal DNA which indicates that they might arise from genetic rearrangements, such as homologous recombination. The abundance of repetitive sequence families in eccDNAs is consistent with the notion that tandem repeats and dispersed repetitive elements participate in intrachromosomal recombination events. There is also evidence that a fraction of this DNA has characteristics similar to retrotransposons. It has been suggested that eccDNAs could reflect altered patterns of gene expression or an instability of chromosomal sequences during development and aging. This article reviews some of the findings and concepts regarding eccDNAs and sequence plasticity in eukaryotic genomes.
Gaubatz
J W
JW
Department of Biochemistry, University of South Alabama College of Medicine, Mobile 36688.
D000818:Animals; D001483:Base Sequence; D004270:DNA, Circular / Q000235:genetics*; D015321:Gene Rearrangement; D005796:Genes; D005838:Genotype; D006801:Humans; D010641:Phenotype; D011995:Recombination, Genetic
D004270:DNA, Circular