title: The role of electrostatic forces in the interaction between the membrane and cytoskeleton of human erythrocytes.
abstract: Evidence is presented that electrostatic forces play a major role in the interaction between the cell membrane and cytoskeleton of human erythrocytes. Experiments were carried out on the effects of ionic strength variation, Ca2+ and Mg2+ ions, dimethonium ion and lipophilic ions on the release of spectrin from the erythrocyte ghost. In addition it was shown that the release of spectrin for fixed Ca2+ or Mg2+ concentration shows a maximum as a function of Na+ concentration. All results are consistent with the existence of a repulsive electrostatic force between membrane and cytoskeleton.
authors.affiliation: Department of Hematology, Ramban Medical Center, Haifa, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Kahana
authors.forename: S
authors.initials: S
authors.lastname: Streichman
authors.forename: B L
authors.initials: BL
authors.lastname: Silver
mesh_terms: D001241:Aspirin / Q000494:pharmacology; D008725:Bis-Trimethylammonium Compounds / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D004563:Electrochemistry; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007455:Iodine / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013049:Spectrin / Q000378:metabolism
chemical_list: D008725:Bis-Trimethylammonium Compounds; D002712:Chlorides; D013049:Spectrin; C047062:dimethonium; D007455:Iodine; D012964:Sodium; D008274:Magnesium; D001241:Aspirin; D002118:Calcium