[The immunomodulating properties and antitumor activity of block copolymers of ethylene oxide and propylene oxide (proxanols)].
Influence of block copolymers of ethylene and propylene oxides (proxanols) on the human natural killer activity was studied. Proxanols had no effect on the lymphocytes viability and increased their cytotoxic activity against target cells K 562 in vitro. Certain antitumor properties of proxanols were demonstrated in vivo (especially for ascitic tumors). The proxanols activity was chiefly determined by the membranotropic properties of its main polymer chain.
Topchieva
I N
IN
Erokhin
V N
VN
Burlakova
E B
EB
Khrutskaia
M M
MM
Kupriianova
T A
TA
Bykovskaia
S Iu
SIu
D000276:Adjuvants, Immunologic; D000818:Animals; D000970:Antineoplastic Agents; D002478:Cells, Cultured / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011060:Poloxalene / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D011060:Poloxalene
Immunomoduliruiushchie svoĭstva i protivoopukholevaia aktivnost' bloksopolimerov okisi étilena i okisi propilena (proksanolov).