title: Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.
abstract: Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of both serotonin uptake sites in frontal cortex and dopamine uptake sites in striatum, suggesting serotonergic and dopaminergic axons terminals were compressed in the smaller brain volumes. The density of S2 serotonin receptors in MAM-lesioned frontal cortex was decreased probably due to down-regulation, while densities of D1 and D2 dopamine receptors in striatum were identical between MAM-lesioned rats and control rats.
authors.affiliation: Department of Psychiatry, National Defense Medical College, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Kinuya
authors.forename: G
authors.initials: G
authors.lastname: Mamiya
authors.forename: T
authors.initials: T
authors.lastname: Tatsunuma
authors.forename: M
authors.initials: M
authors.lastname: Nagayoshi
authors.forename: T
authors.initials: T
authors.lastname: Matsutani
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013723:Teratogens
chemical_list: D011985:Receptors, Serotonin; D013723:Teratogens; D012701:Serotonin; D008746:Methylazoxymethanol Acetate; C030667:methylazoxymethanol; D004298:Dopamine