title: Antiulcer activity of some PG-like derivatives and their intermediates.
abstract: During a search on PG-like compounds as antiulcer drugs we synthetized some hetherocyclic derivatives. Some compounds of this series were found to be effective after oral administration in inhibiting restraint induced ulcers in the rat. Three of the most active compounds showed fairly good antiinflammatory activity in the carrageenin-induced rat paw oedema test and in the RPAR test.
authors.affiliation: Formenti Group, Research Laboratories, Origgio, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Passarotti
authors.forename: G L
authors.initials: GL
authors.lastname: Bandi
authors.forename: L
authors.initials: L
authors.lastname: Citerio
authors.forename: M
authors.initials: M
authors.lastname: Valenti
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis; D011465:Prostaglandins, Synthetic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D011465:Prostaglandins, Synthetic