EGF receptor induction and insulin-EGF overlap in Tetrahymena.
Offspring generations of Tetrahymena pretreated (imprinted) with insulin showed a greater binding capacity for the hormone than offspring of untreated ones. The epidermal growth factor (EGF) imprinted for insulin to a greater degree than insulin itself, and vice versa: insulin imprinted for EGF more efficiently than EGF itself. These phenomena can be explained by the overlap of insulin and EGF on one another's receptors in Tetrahymena.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Kovács
P
P
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D013768:Tetrahymena / Q000378:metabolism*
D007328:Insulin; D066246:ErbB Receptors