[Autoantibodies against the complement component C1q in systemic lupus erythematosus].
Autoantibodies against C1q, a subcomponent of the first complement component C1, could be detected in 49.4% of sera from patients with systemic lupus erythematosus (SLE). They are directed against the collagen-like portion of the C1q molecule and recognize only bound, but not fluid-phase C1q. The appearance of these autoantibodies in the course of SLE correlates with the detection of IgG in the C1q-Solid-Phase-Binding-assay, with high titres of dsDNA-antibodies and with depressed total complement activity (CH50) and C1q-values. Our investigations show that autoantibodies against the collagen-like portion of bound C1q but not immune complexes are the main constituent of C1q-binding IgG in SLE.
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Institut für Medizinische Mikrobiologie, Johannes Gutenberg Universität Mainz.
Heinz
H P
HP
Hartung
K
K
Loos
M
M
D001323:Autoantibodies / Q000302:isolation & purification*; D003167:Complement Activation; D015922:Complement C1q / Q000276:immunology*; D004247:DNA / Q000276:immunology / Q000302:isolation & purification; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D001323:Autoantibodies; D015922:Complement C1q; D004247:DNA
Autoantikörper gegen die Komplementkomponente C1q beim Systemischen Lupus Erythematodes.