[Preliminary evaluation of the effectiveness of induction chemotherapy with cisplatin and 5-fluorouracil in patients with advanced squamous cell carcinoma of the head and neck].
Results of combined treatment with the use of induction chemotherapy with cisplatinum and 5-fluorouracil in 28 patients with advanced squamous cell head and neck cancer are presented. Treatment schedule included cisplatinum 100 mg/m2 i.v. in day 1 and 5-fluorouracil 100 mg/m2/24 hour in days 1-5. Complete or partial regression was observed in 15 patients (53%) Radical radiotherapy was subsequently used in 18 patients and 6 were irradiated palliatively++. One year symptom-free survival was achieved in 10 patients (36%).
Migdał
K
K
Kliniki Radioterapii Centrum Onkologii Instytutu im. Marii Skodowskiej-Curie, Oddział, Krakowie.
Korzeniowski
S
S
Skołyszewski
J
J
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction
D002945:Cisplatin; D005472:Fluorouracil
Wstepna ocena skuteczności chemioterapii indukcyjnej cisplatyna i 5-fluorouracilem chorych na zaawansowanego płaskonabłonkowego raka głowy i szyi.