Effect of antiplatelet drug therapy on the retinal vascular pattern in experimental diabetes mellitus.
We performed a study to evaluate the effect of acetylsalicylic acid (ASA) plus dipyridamole on the retinal vascular pattern over 3 months in rats with experimental diabetes mellitus. Rats treated with ASA alone showed a continuous vascular bed and less tortuous vessels than untreated diabetic rats. Rats treated with ASA plus dipyridamole showed a continuous vascular bed, scarce tortuous vessels and vascular diameters similar to those in nondiabetic control rats. The findings were related to aortic prostacyclin production: treatment with ASA alone produced a reduction in prostacyclin production, whereas treatment with ASA plus dipyridamole resulted in normal prostacyclin production. ASA alone or with dipyridamole inhibited collagen-induced aggregation in whole blood by 57% compared with the untreated diabetic rats.
de la Cruz
J P
JP
Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Spain.
Moreno
A
A
Sanchez de la Cuesta
F
F
García Campos
J
J
D000818:Animals; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000188:drug therapy; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D011464:Epoprostenol / Q000378:metabolism; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012171:Retinal Vessels / Q000187:drug effects* / Q000473:pathology
D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D003094:Collagen; D011464:Epoprostenol; D001241:Aspirin