title: High-dose leucovorin, fluorouracil and oral dipyridamole in the treatment of advanced colorectal cancer.
abstract: Fifty-five patients with advanced colorectal cancer were treated with the combination of leucovorin (LV), fluorouracil (FU) and dipyridamole (DP). Two (4%) patients achieved a clinical complete remission, 4 (7%) a partial remission, 24 (44%) had stable disease while 25 (45%) patients progressed during the chemotherapy period. Median survival was 47 weeks and median time to progression 19.5 weeks. Major toxicities included diarrhea (66%), leukopenia (45%), anemia (50%) and nausea/vomiting (44%). In conclusion, the addition of oral DP does not appear to improve the efficacy of the standard LV/FU regimen in patients with advanced colorectal cancer.
authors.affiliation: AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Fountzilas
authors.forename: A
authors.initials: A
authors.lastname: Zisiadis
authors.forename: P
authors.initials: P
authors.lastname: Kosmidis
authors.forename: G
authors.initials: G
authors.lastname: Basdanis
authors.forename: P
authors.initials: P
authors.lastname: Makrantonakis
authors.forename: A
authors.initials: A
authors.lastname: Paspatis
authors.forename: D
authors.initials: D
authors.lastname: Tsavdaridis
authors.forename: N
authors.initials: N
authors.lastname: Tsavaris
authors.forename: O
authors.initials: O
authors.lastname: Aletras
authors.forename: A
authors.initials: A
authors.lastname: Tourkantonis
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004176:Dipyridamole / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012004:Rectal Neoplasms / Q000188:drug therapy*
chemical_list: D004176:Dipyridamole; D002955:Leucovorin; D005472:Fluorouracil