[The effect of calcium antagonists on the rate of gastric emptying in patients with duodenal peptic ulcer and the dumping syndrome].
Comparative evaluation of single-dose finoptin, corinfar and falicor by effect on gastric evacuation was conducted in 33 peptic ulcer and 48 postgastrectomy dumping syndrome patients. Finoptin was found to prolong the evacuation in contrast to corinfar which stimulated it. Nonsignificant delay in gastric evacuation occurred in falicor administration. When designing therapy of cardiovascular diseases associated with gastric evacuation, due consideration should be given to pharmacokinetic action of calcium antagonists and functional status of gastric evacuation. Finoptin is preferable in dumping syndrome, corinfar in slow gastric evacuation. In view of the above corinfar treatment is undesirable in postgastrectomy patients, otherwise they could develop rapid gastric stump evacuation and dumping syndrome.
Saakian
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AG
D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002908:Chronic Disease; D004377:Dumping Syndrome / Q000503:physiopathology*; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D009930:Organic Chemicals; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D009930:Organic Chemicals; C067932:falicor; D014700:Verapamil; D009543:Nifedipine
O vliianii antagonistov kal'tsiia na skorost' oporozhneniia zheludka ot pishchi u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki i demping-sindromom.