title: 3-O-methyl-D-glucose uptake by erythrocytes of normal and diabetic subjects.
abstract: The uptake of 3-O-[14C]methyl-D-glucose was measured in erythrocytes of normal and non-insulin-dependent diabetic subjects. In normal subjects, the uptake of the sugar was rapid, saturable, temperature-sensitive and inhibited by cytochalasin B. Over 30 s incubation at 20 degrees C, the uptake of 3-O-[14C]methyl-D-glucose (20 mM) was lower in diabetic than in normal subjects. These findings raise the view that an alteration of hexose transport into insulin-insensitive cells may participate to the perturbation of glucose homeostasis in diabetic patients.
authors.affiliation: Endocrinology and Diabetes Unit, Hospital Clinic, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Gomis
authors.forename: C
authors.initials: C
authors.lastname: Tomas
authors.forename: A
authors.initials: A
authors.lastname: Novials
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D019325:3-O-Methylglucose; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008757:Methylglucosides / Q000097:blood*; D008875:Middle Aged
chemical_list: D008757:Methylglucosides; D019325:3-O-Methylglucose