title: [Efficacy and tolerance of cyclosporin A in the treatment of multiple sclerosis].
abstract: The use and tolerance of cyclosporine A (Cy A) and azathioprine (AZA) are compared as long-term immunosuppression treatment for multiple sclerosis. 38 patients with multiple sclerosis were randomized and received either Cy A (5 mg/kg/d) or AZA (2 mg/kg/d) during 24 months. These patients were assessed clinically and with different biological parameters. The Cy A blood level was controlled, and Cy A was well tolerated without side effects forcing to stop the treatment. However, its benefits were limited when the different clinical scores are compared.
authors.affiliation: Service de neurologie, CHUV, Lausanne.
authors.forename: M
authors.initials: M
authors.lastname: Schluep
authors.forename: A J
authors.initials: AJ
authors.lastname: Steck
authors.forename: P A
authors.initials: PA
authors.lastname: Despland
authors.forename: F
authors.initials: F
authors.lastname: Regli
authors.forename: F
authors.initials: F
authors.lastname: Ochsner
authors.forename: E
authors.initials: E
authors.lastname: Berrut
authors.forename: G
authors.initials: G
authors.lastname: Gauthier
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D003524:Cyclosporins; D001379:Azathioprine
vernacular_title: Efficacité et tolérance de la cyclosporine A dans le traitement de la sclérose en plaques.