title: Failure of prolonged treatment with ciprofloxacin in acute infections due to Brucella melitensis.
abstract: A randomized prospective, pilot study was performed to compare the efficacy of oral ciprofloxacin (750 mg or 1000 mg bd) with standard oral antimicrobial therapy (rifampicin plus doxycycline) in the treatment of acute infection with Brucella melitensis. All antimicrobial drugs were administered for 42 days. Although all patients responded rapidly, five of the six patients receiving ciprofloxacin relapsed following cessation of therapy. There were no relapses among the patients who received doxycycline/rifampicin. Despite its in-vitro activity against B. melitensis (MIC 0.5 mg/l), ciprofloxacin, administered twice daily, does not appear to constitute adequate therapy for acute brucellosis.
authors.affiliation: Clinical Infectious Disease Unit, Meir Hospital, Kfar Saba, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Lang
authors.forename: R
authors.initials: R
authors.lastname: Raz
authors.forename: T
authors.initials: T
authors.lastname: Sacks
authors.forename: M
authors.initials: M
authors.lastname: Shapiro
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002006:Brucellosis / Q000188:drug therapy* / Q000382:microbiology; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011897:Random Allocation; D012008:Recurrence; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D002939:Ciprofloxacin; D004318:Doxycycline; D012293:Rifampin