title: Infection of human gastrointestinal cells by HIV-1.
abstract: Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission.
authors.affiliation: Department of Surgery, University of Texas Health Science Center, San Antonio.
authors.forename: M P
authors.initials: MP
authors.lastname: Moyer
authors.forename: R I
authors.initials: RI
authors.lastname: Huot
authors.forename: A
authors.initials: A
authors.lastname: Ramirez
authors.forename: S
authors.initials: S
authors.lastname: Joe
authors.forename: M S
authors.initials: MS
authors.lastname: Meltzer
authors.forename: H E
authors.initials: HE
authors.lastname: Gendelman
mesh_terms: D002478:Cells, Cultured; D003106:Colon / Q000382:microbiology*; D003588:Cytopathogenic Effect, Viral; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000166:cytology / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology*; D013997:Time Factors; D014779:Virus Replication