Identification of a beta-turn in the tertiary structure of a peptide fragment of the Alzheimer amyloid protein.
In an attempt to understand the three-dimensional structure of the Alzheimer amyloid protein, a fragment decapeptide was studied by nuclear magnetic resonance spectroscopy. Using two-dimensional techniques, protons close in space were identified and their interproton distances determined. These distances were then used as input data for distance geometry calculations. The resulting three-dimensional structures suggest the presence of a beta-turn in the C-terminus of the decapeptide.
Sorimachi
K
K
School of Pharmaceutical Chemistry, Victorian College of Pharmacy Ltd., Parkville, Victoria, Australia.
Craik
D J
DJ
Lloyd
E J
EJ
Beyreuther
K
K
Masters
C L
CL
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry*; D011487:Protein Conformation
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments