Distribution of acid phosphatase and beta-glucuronidase in the hypoplastic cerebellum of jaundiced Gunn rats. An enzyme histochemical study.
Activities of acid phosphatase and beta-glucuronidase in the cerebella of young jaundiced (j/j) and non-jaundiced (j/+; control) Gunn rats were studied with the enzyme histochemical method. The cerebellum of j/+ rats showed high acid phosphatase activities in Purkinje cells and neurons in the cerebellar nuclei. In j/j rats, a number of neurons were lost and numerous microglialike cells with a high acid phosphatase activity appeared in the hypoplastic cerebellum. Although beta-glucuronidase activity was rarely detected in the control cerebellum, a high enzyme activity was observed associated with microglialike cells in j/j rats. The present results provide a cytological basis for the reported differential increase in the activities of these lysosomal enzymes in the j/j rat cerebellum.
Keino
H
H
Department of Perinatology, Institute for Developmental Research, Aichi Prefecture Colony, Japan.
Sato
H
H
Kashiwamata
S
S
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000002:abnormalities / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism*; D006651:Histocytochemistry / Q000379:methods; D007565:Jaundice / Q000201:enzymology*; D051381:Rats; D011911:Rats, Gunn
D000135:Acid Phosphatase; D005966:Glucuronidase