The effect of oxidizing agents on cell division and shape.
Certain oxidizing agents such as vitaminK(VK) and lipid peroxides were found to suppress an increase in cytoplasmic Ca2+ concentration by growth factors, and inhibit on cell proliferation. These oxidizing agents induced a marked change in cell shape. In a detailed analysis of each phase in the cell cycle, the inhibition of an increase in cytoplasmic Ca2+ and cell division occurred only when the agents were added at G0/G1 phase. The addition to S or M phase cells did not influence in cytoplasmic Ca2+ and cell division. These experimental results suggest that these oxidizing agents may inhibit the transfer of stimulation signals from growth factors by acting on cell membrane sites and suppress subsequent DNA replication and mitotic division.
Tomono
M
M
Department of Biochemistry, Toho University School of Medicine.
Urayama
T
T
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D003593:Cytoplasm / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D003864:Depression, Chemical; D006801:Humans; D007399:Interphase / Q000187:drug effects; D008054:Lipid Peroxides / Q000494:pharmacology*; D051379:Mice; D015290:Second Messenger Systems / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014812:Vitamin K / Q000494:pharmacology*
D008054:Lipid Peroxides; D014812:Vitamin K; D002118:Calcium