[Effects of praeruptorin C on isolated guinea pig atrium and myocardial compliance in patients].
Praeruptorin C (Pra-C, 2-methyl-,10-(acetyloxy)-9,10- dihydro-8,8-dimethyl-2-oxo-2H, 8H-benzo[1,2-b:3,4-b'] dipyran-9-ol ester of 2-butenoic acid) was first isolated by Chinese researcher. Pra-C 10 mumol/L reduced automatic rhythm and positive chronotropic effects of CaCl2 in right atrium. Its antagonistic effects on isoproterenol-mediated increase in beat rate were non-competitive with a pD'2 of 4.8. Pra-C 5-50 mumol/L shortened functional refractory period with little effects on the excitability and epinephrine-induced ecotopic automaticity. Modification of myocardial compliance during 2 wk oral Pra-C therapy in patients with hypertrophic cardiomyopathy was also investigated.
Wu
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Department of Cardiovascular Pharmacology, Nanjing Medical College, China.
Rao
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MR
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy; D003374:Coumarins / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D002121:Calcium Channel Blockers; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C058808:praeruptorin C