A follow-up study of colonic epithelial proliferation as a biomarker ina Native-American family with hereditary nonpolyposis colon cancer.
A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary nonpolyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normal range. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterizes the Native-American population in the American Southwest.
Lynch
P M
PM
Section of Gastrointestinal Oncology and Digestive Disease, M.D. Anderson Cancer Center, Houston, TX 77030.
Wargovich
M J
MJ
Lynch
H T
HT
Palmer
C
C
Lanspa
S
S
Drouhard
T
T
Lynch
J
J
D000328:Adult; D001345:Autoradiography; D014408:Biomarkers, Tumor / Q000032:analysis*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D003106:Colon / Q000378:metabolism; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007198:Indians, North American / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014316:Tritium
D014408:Biomarkers, Tumor; D014316:Tritium; D001973:Bromodeoxyuridine