[Assay of S-100+ Langerhans cells in cervical carcinoma].
Langerhans cells (LC) in the normal cervix (control, 19 cases) and cervical carcinoma in situ (CIS, 19 cases), interdigitating cells (IDC) and follicular dendritic cells (FDC) in obturator lymph node draining infiltrating cervical carcinoma (30 cases) were quantitatively assayed by ABC immunohistochemical method using anti-S-100 protein antibody. The results indicated that S-100+ LC in situ, S-100+ IDC and S-100+ FDC in obturator lymph node showed dendritic features with a specific distribution. The number of LC in situ in infiltrating carcinoma increased significantly as compared with CIS and control groups. There was no change in LC number between Grades II and III of squamous cell carcinoma. The number of IDC was significantly less in Stage II than in Stage I lesion. FDC number in different depths of invasion and clinical stages showed no obvious change. The results suggest that progression of cervical carcinoma is closely related to decrease in LC in situ and IDC in regional lymph node. Predominant immune response of the host to cervical carcinoma should be cellular immune.
Xie
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Women's Hospital, Zhejiang Medical College, Hangzhou.
D000906:Antibodies / Q000032:analysis; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000276:immunology*; D009361:Neoplasm Invasiveness; D009418:S100 Proteins / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D000906:Antibodies; D009418:S100 Proteins