Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis.
Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/- 42 pg/ml) in PDE, while IL-6 was undetectable in serum. In 6 patients with staphylococcal peritonitis, a tremendous increase in PDE levels of IL-6 was noted (range: 5,832-37,491 pg/ml), while serum IL-6 remained either undetectable or on a low level except in one case. After 5 days of antibiotic treatment, IL-6 levels in PDE returned to basal values. We conclude that CAPD results in an intraperitoneal secretion of IL-6 which is markedly but transiently increased during peritonitis episodes.
Goldman
M
M
Department of Nephrology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Vandenabeele
P
P
Moulart
J
J
Amraoui
Z
Z
Abramowicz
D
D
Nortier
J
J
Vanherweghem
J L
JL
Fiers
W
W
D001202:Ascitic Fluid / Q000737:chemistry*; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000378:metabolism* / Q000382:microbiology / Q000628:therapy; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000378:metabolism; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use
D015850:Interleukin-6; D014640:Vancomycin; D002437:Cefazolin