[Analysis of the association of inherited predisposition to breast cancer with c-Ha-ras-1 oncogene alleles].
Polymorphism of the human c-Ha-ras-1 gene has been analysed in 66 BamHI restricted DNAs from blood of 35 patients with "inherited" breast cancer, 7 fibroadenoma patients, 13 healthy first-degree relatives and 11 unaffected controls. Two "common" and four "unusual" alleles were detected. The frequency of "common" (6.6 and 7.4 kb) and "unusual" (6.9 kb) alleles was identical to that in the control and unaffected groups (65.8, 17.1 and 7.1%). Rare alleles (7.6 and 7.8 kb) were only detected in breast cancer patients and in healthy first-degree relatives. A 8.0 kb allele specific for control patients was also detected. No absolute relationship between the genetic predisposition to breast cancer and the Ha-ras genotype was assumed.
Nefedov
M D
MD
Gar'kavtsev
I V
IV
Rogaev
E I
EI
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D011905:Genes, ras / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics
Analiz assotsiatsii nasledstvennoĭ predraspolozhennosti k raku molochnoĭ zhelezy s allel'nymi variantami c-Ha-ras-1 onkogena.