title: Quantitative analysis of basal dendrites of prefrontal pyramidal cells after chronic alcohol consumption and withdrawal in the adult rat.
abstract: The effects of chronic alcohol consumption and withdrawal on the organization of the basal dendrites of layer III pyramidal cells of the prelimbic cortex were studied in groups of rats fed on alcohol for 6 or 18 months, and in a group fed for 12 months, then switched to water for a further 6 months (withdrawal group). Three-dimensional analysis of the dendritic arborizations showed an age-dependent increase in several dendritic parameters, but a net stability was found in the metrical parameters between alcohol-fed and respective control rats. Conversely, a dendritic impoverishment occurred in the withdrawal group. The linear density of dendritic spines remained stable in all groups studied. Together with the previously found marked loss of the neurons after alcohol consumption and withdrawal, these findings point to a decrease in the available targets for afferents and therefore to the presence of probable functional alterations as a consequence of those in the connectivity patterns of the prelimbic area occurring under these conditions.
authors.affiliation: Department of Anatomy, Porto Medical School, Alameda Hernâni Monteiro, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Cadete-Leite
authors.forename: M C
authors.initials: MC
authors.lastname: Alves
authors.forename: M M
authors.initials: MM
authors.lastname: Paula-Barbosa
authors.forename: H B
authors.initials: HB
authors.lastname: Uylings
authors.forename: M A
authors.initials: MA
authors.lastname: Tavares
mesh_terms: D000430:Alcohol Withdrawal Delirium / Q000473:pathology*; D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D003712:Dendrites / Q000187:drug effects / Q000648:ultrastructure*; D000431:Ethanol / Q000633:toxicity*; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol