Aspects of quality of life on treatment with felodipine.
Quality of life has been assessed in a double-blind four week study comparing felodipine 5, 10, 20 mg and placebo added to metoprolol by adding two self-administered questionnaires to the conventional procedure for the evaluation of adverse events. None of the aspects related to general well-being was affected by felodipine. The subjective symptoms reported were mostly dose-related and so here mainly observed at the highest dose. Some of them, e.g. headache, were transient. It is concluded that felodipine in combination with metoprolol CR did not negatively influence the feeling of well-being of the patients. When the drug was given in low, individually adjusted doses, the symptoms normally associated with Ca antagonists were likely to be minimised.
Dimenäs
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E
Research Laboratories, AB Hässle, Mölndal, Sweden.
Wallander
M A
MA
Svärdsudd
K
K
Wiklund
I
I
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D015736:Felodipine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage; D008875:Middle Aged; D011788:Quality of Life; D016037:Single-Blind Method; D013223:Statistics as Topic; D011795:Surveys and Questionnaires
D008790:Metoprolol; D015736:Felodipine