[The effect of sodium benzyl-penicillin on the mean quantal levels of released acetylcholine].
Examined are effects of different doses of potassium (2.500 IU/ml) and sodium (5.000 IU/ml) (10.000 IU/ml) of benzylpenicillin on the mean quantum content (MQC) of the released acetylcholine in the phrenicus-hemidiaphragm specimens in rats. Very significant MQC decrease depending on the given antibiotic doses was found. Presented was hypothesis that the MQC decrease could result in the decreased Ca++ ion entering the terminal axoplasm under the benzylpenicillin molecule effect.
Dragić
S
S
Institut za eksperimentalnu medicinu, Vojnomedicinska Akademija, Medicinski Fakultet, Tuzla.
Malicević
Z
Z
Stamenović
B
B
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D003964:Diaphragm / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010400:Penicillin G / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000109:Acetylcholine; D010400:Penicillin G
Uticaj natrijumbenzil-penicilina na srednji kvantalni iznos oslobodenog acetilholina.