Chemically-modified polysaccharides for enzymatically-controlled oral drug delivery.
Starch polysaccharides were investigated as bioerodible matrices for enzymatically-controlled oral drug delivery. Corn starch was ionically cross-linked with calcium chloride. It was found that the cross-linked starch could be used for entrapment and controlled release of bioactive molecules. The release rate of large molecules was degradation-dependent due to amylase activity, which might target the release to the intestine, when the particles were taken orally. The release of small molecules such as salicylic acid, was mainly by diffusion.
Kost
J
J
Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Shefer
S
S
D000284:Administration, Oral; D001673:Biodegradation, Environmental / Q000187:drug effects; D002021:Buffers; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011134:Polysaccharides / Q000737:chemistry*; D013213:Starch / Q000737:chemistry; D000516:alpha-Amylases / Q000494:pharmacology*
D002021:Buffers; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D011134:Polysaccharides; D013213:Starch; D000516:alpha-Amylases