Perianal ulcer in disseminated histoplasmosis.
A 65-year-old man with stage I testicular seminoma, treated with surgery and radiation, had fever of unknown origin, adrenal insufficiency, and an isolated perianal ulcer. Tissue diagnosis of disseminated histoplasmosis was established by biopsy of the perianal ulcer, an unusual cutaneous manifestation of the disease. Treatment with amphotericin B resulted in rapid clinical improvement and complete healing of the perianal ulcer.
Recondo
G
G
Department of Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Sella
A
A
Ro
J Y
JY
Dexeus
F H
FH
Amato
R
R
Kilbourn
R
R
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001004:Anus Diseases / Q000188:drug therapy / Q000382:microbiology*; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D012883:Skin Ulcer / Q000188:drug therapy / Q000382:microbiology
D000666:Amphotericin B