Persistent light reactivity from systemic quinine.
A 41-year-old black female with psoriasis developed photosensitivity and a Koebner reaction while receiving phototherapy. She had been receiving oral quinine intermittently for muscle cramps. Photobiological evaluation revealed a strongly positive photopatch test to quinine sulfate and a marked persistent reduction in the minimal erythema dose to solar-simulated radiation in the uninvolved skin. There were no abnormal reactions to UVA. The photosensitivity is still present 3 years after the withdrawal of quinine. These features are similar to those observed previously in persistent light reactors to topical photosensitizers.
Guzzo
C
C
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Kaidbey
K
K
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011565:Psoriasis / Q000188:drug therapy / Q000532:radiotherapy; D011803:Quinine / Q000009:adverse effects*; D012008:Recurrence; D014467:Ultraviolet Therapy / Q000009:adverse effects
D011803:Quinine