title: Effects of tracer blood measurement noise on glucose metabolic rate estimation.
abstract: Tracer kinetic modeling with Positron Emission Tomography (PET) requires measurements of the time-activity curves in both plasma (PTAC) and tissue (TTAC) to estimate physiological parameters. However, the estimation usually ignores the measurement noise in plasma tracer activity curves. The accuracy and reliability of the physiological parameters estimated by ignoring such noise are not well understood. In this paper, computer simulations were performed to investigate the influence of input measurement noise on the accuracy of estimates. The results show that input measurement noise causes considerable variability in the parameter estimates.
authors.affiliation: Basser Department of Computer Science, University of Sydney, N.S.W., Australia.
authors.forename: D
authors.initials: D
authors.lastname: Feng
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Fulton
authors.forename: B
authors.initials: B
authors.lastname: Hutton
authors.forename: J
authors.initials: J
authors.lastname: Morris
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003198:Computer Simulation; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008954:Models, Biological; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose