A novel skeletal drug delivery system for anti-bacterial drugs using self-setting hydroxyapatite cement.
To solve the problem of delivering drugs to skeletal tissue at high enough local concentrations for desirable therapeutic effects, we report a novel approach using a self-setting hydroxyapatite cement, with cephalexin and norfloxacin as model drugs. After setting, the cement was transformed into hydroxyapatite with affinity for hard bone tissue. Continuous in-vitro drug release profiles from loaded cement pellets (0.9-4.8% by weight) in phosphate buffer at pH 7.4 and 37 degrees C followed the Higuchi equation.
Otsuka
M
M
Kobe Women's College of Pharmacy, Japan.
Matsuda
Y
Y
Yu
D
D
Wong
J
J
Fox
J L
JL
Higuchi
W I
WI
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D005079:Excipients; D006882:Hydroxyapatites / Q000737:chemistry*; D014961:X-Ray Diffraction
D000890:Anti-Infective Agents; D005079:Excipients; D006882:Hydroxyapatites