Intragastric device for weight loss. Effect on energy intake in dogs.
It remains unclear whether or not intragastric devices promote weight loss. To elucidate if an intragastric balloon reduces energy intake by a placebo effect of inducing satiety, five free-feeding dogs had balloons inserted via a gastric cannula. Meal intake was assessed with the balloons inflated to 200 and 500 ml with saline and compared with intake during a control period when the animals maintained stable weight. Average energy intake during the control period was 0.3 MJ/kg/day. Inflation to 200 ml had no significant effect on intake (0.31 MJ/kg/day), whereas inflation to 500 ml significantly reduced energy intake to 0.14 MJ/kg/day (P less than 0.0001). An intragastric balloon does create aversion to feeding, presumably by producing satiety, but the effect is volume dependent.
Durrans
D
D
University Department of Surgery, Manchester Royal Infirmary, UK.
Taylor
T V
TV
Holt
S
S
D000818:Animals; D004285:Dogs; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D015905:Gastric Balloon; D008297:Male; D008991:Monitoring, Physiologic; D010418:Pentagastrin / Q000494:pharmacology; D012528:Satiety Response / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*
D010418:Pentagastrin