[Is the qualitative research of benzodiazepines by the EMIT method and diazocopulation in accidental poisoning in children relevant?].
A retrospective study was undertaken to evaluate the relevance of benzodiazepine detection in 42 children with accidental poisoning. Immunoenzymatic assay for benzodiazepine in serum and colorimetric method in urines were positive respectively in 3 and 4 patients only. Several reasons could explain these results: the high detection threshold, the different drug reactivity according to the molecular structure and the great delay between intoxication and toxicology analysis. An advised physician should not prescribe a toxicological analysis after a small quantity of benzodiazepine ingestion.
Dutertre
J P
JP
Services de Pharmacologie Clinique et de Pédiatrie, Hôpital Bretonneau, C.H.U. Tours.
Autret
E
E
Breteau
M
M
Grenier
B
B
Rolland
J C
JC
Laugier
J
J
D001569:Benzodiazepines / Q000737:chemistry* / Q000506:poisoning; D002675:Child, Preschool; D003124:Colorimetry / Q000379:methods; D005602:France; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies
D001569:Benzodiazepines
La recherche qualitative de benzodiazépines par la méthode EMITSt et la diazocopulation au cours des intoxications accidentelles de l'enfant est-elle pertinente?