Effect of subacute insecticide exposure on body weight, drug responses & electrical convulsions in mice.
Effect of subacute insecticide exposure was studied in male albino mice treated with phosphamidon, propoxur or aldrin at 1/40 LD50 dose intraperitoneally daily for 8 wk. The parameters studies included body weight, pentobarbitone (50 mg/kg) sleeping time, chlorpromazine (6 mg/kg) induced motor incoordination and convulsions induced by leptazol (100 mg/kg) and electrical stimulation (18 mA for 0.2 msec). While body weight and electrically induced convulsions were not affected, the effect of various drugs was significantly decreased. The observed changes may be due to the induction of hepatic drug metabolising enzymes by the insecticides. The study suggests that certain dose adjustment of drugs may be necessary in those exposed to insecticides over long periods.
Agarwal
A K
AK
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Sankaranarayanan
A
A
Sharma
P L
PL
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D004347:Drug Interactions; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D010573:Pesticide Residues / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D007306:Insecticides; D010573:Pesticide Residues; D010424:Pentobarbital; D002746:Chlorpromazine; D010433:Pentylenetetrazole