[Relations of melatonin level and insufficiency of T and B immune components in children with acute viral neuroinfections].
A study was made of the content of melatonin, cortisol and indicators of cellular (E-rosette formation, 3H-lymphocyte blast transformation) and humoral (E AC-rosette formation, IgA, IgM IgG) immunity in 36 children with acute viral neuroinfections (encephalitis, encephalomyelitis, chorio-ependymitis, polyradiculoneuritis). The children's age ranged from 7 to 14 years. A significant correlation was determined between the levels of melatonin, cortisol, 3H-lymphocyte blast transformation and IgG. Variants of immunomodulating therapy are provided, bearing in mind the disorders revealed.
Evtushenko
S K
SK
Svechkin
O V
OV
Samsonenko
R A
RA
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008550:Melatonin / Q000097:blood*; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology* / Q000628:therapy; D012397:Rosette Formation; D014777:Virus Diseases / Q000097:blood / Q000276:immunology* / Q000628:therapy
D000276:Adjuvants, Immunologic; D007136:Immunoglobulins; D008550:Melatonin; D006854:Hydrocortisone
O vzaimosviazi urovnia melatonina i nedostatochnosti T- i B-zven'ev immuniteta u deteĭ s ostrymi virusnymi neĭroinfektsiiami.