[Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr].
During our screening of pharmacologically active principles from Indonesian medicinal plants by a hypothermic effect the methanol-extract of Brucea javanica (L.) Merr. has been found to exhibit a lethal toxicity to mice. The toxic components were isolated and identified with bruceoside A and B and yadanzioside F. Correction of 13C-nuclear magnetic resonance assignment was also mentioned.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Gao
L H
LH
Yamazaki
M
M
D000818:Animals; D005334:Fever / Q000139:chemically induced*; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity*; D010946:Plants, Medicinal / Q000032:analysis*; D036702:Quassins
D010936:Plant Extracts; D036702:Quassins; C020236:bruceoside A; C068162:bruceoside B; C068163:yadanzioside F; D005900:Glaucarubin