Effect of polyoxyethylene-modified superoxide dismutase on recovery of myocardial dysfunction after coronary stenosis in dogs.
The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs. SOD-POE or saline was administered i.v. 30 min before reperfusion. Changes in hemodynamic variables and SS by CSPT were similar in both groups. However, the SOD-POE group showed improved recovery of SS compared with the control group. Results indicate that oxygen-derived free radicals may partially be involved in the genesis of myocardial dysfunction after CSPT-induced regional ischemia.
Noguchi
K
K
Department of Pharmacology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Ojiri
Y
Y
Kinjo
N
N
Moromizato
H
H
Nakasone
J
J
Sakanashi
M
M
D000818:Animals; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology*; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D015425:Myocardial Reperfusion; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013610:Tachycardia / Q000209:etiology
D011092:Polyethylene Glycols; D013482:Superoxide Dismutase