title: Clinical applications of fluorescence in situ hybridization.
abstract: We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberrations important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.
authors.affiliation: Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA 94550.
authors.forename: D C
authors.initials: DC
authors.lastname: Tkachuk
authors.forename: D
authors.initials: D
authors.lastname: Pinkel
authors.forename: W L
authors.initials: WL
authors.lastname: Kuo
authors.forename: H U
authors.initials: HU
authors.lastname: Weier
authors.forename: J W
authors.initials: JW
authors.lastname: Gray
mesh_terms: D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D005821:Genetic Techniques; D006801:Humans; D008856:Microscopy, Fluorescence; D009693:Nucleic Acid Hybridization; D015341:Nucleic Acid Probes
chemical_list: D015341:Nucleic Acid Probes