The role of cytochrome P450IIE1 in bioactivation of acetaminophen in diabetic and acetone-treated mice.
Jeffery
E H
EH
College of Veterinary Medicine, Institute for Environmental Studies, University of Illinois, Urbana-Champaign 61801.
Arndt
K
K
Haschek
W M
WM
D000082:Acetaminophen / Q000493:pharmacokinetics* / Q000633:toxicity; D000096:Acetone / Q000494:pharmacology; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*
D000096:Acetone; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D010089:Oxidoreductases, N-Demethylating; D004121:Dimethyl Sulfoxide