Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis.
A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prevention of delayed rebound toxicity was documented. We suggest that this is the therapy of choice in similar individuals.
Rabetoy
G M
GM
Department of Internal Medicine (Nephrology Division), Naval Hospital, San Diego, Calif.
Price
C A
CA
Findlay
J W
JW
Sailstad
J M
JM
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000368:Aged; D004077:Digoxin / Q000276:immunology / Q000506:poisoning*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D009101:Multiple Myeloma / Q000150:complications*; D010956:Plasmapheresis; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis
D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin