Effect of vitamin A acid on papillomas induced by irradiated bed bugs in rabbit skin.
The preventive effect of vitamin A acid (13-cis-retinoic acid) on skin papillomas induced in rabbits (Oryctolagus cuniculus) by the bite of bed bugs (Cimex lectularius) pre-irradiated with gamma rays was investigated. Painting the papillomas with an oily 13-cis-retinoic acid suspension twice a week in a dose of 25 mg/kg body weight leads to significant regression of these structures.
Sakr
S A
SA
Department of Zoology, Faculty of Science, Menoufia University, Shebin El-Koom, Egypt.
D000818:Animals; D000970:Antineoplastic Agents; D001511:Bedbugs / Q000528:radiation effects; D008297:Male; D010212:Papilloma / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology; D014212:Tretinoin / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014212:Tretinoin