title: Evaluation of equine digital Starling forces and hemodynamics during early laminitis.
abstract: A carbohydrate overload model was used in 8 horses to evaluate Starling forces and hemodynamics of the digit during the prodromal stage of acute laminitis. A pump-perfused extracorporeal digital preparation was used to evaluate blood flow, arterial pressure, venous pressure, capillary pressure, isogravimetric capillary filtration coefficient, osmotic reflection coefficient, and vascular compliance. From these data, pre- and postcapillary resistances and pre- to postcapillary resistance ratios were determined. Vascular and tissue oncotic pressures were estimated from plasma and lymph protein concentrations, respectively. The osmotic reflection coefficient, an estimation of capillary permeability, was determined by means of the lymph protein wash-down technique. Using the collected data, tissue pressure in the digit was calculated by use of the Starling equation. In the isolated digit, mean isogravimetric capillary pressure was 55.13 mm of Hg, mean plasma and lymph oncotic pressures were 22.29 mm of Hg and 7.2 mm of Hg, respectively, the mean osmotic reflection coefficient was 0.66, the mean capillary filtration coefficient was 0.003 ml/min/mm of Hg/100 g, and mean interstitial fluid pressure was 44.82 mm of Hg. The high capillary pressure appeared to be caused by high vascular resistance from the venous side, predisposing to enhanced capillary filtration and interstitial fluid accumulation.
authors.affiliation: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: E S
authors.initials: ES
authors.lastname: Clark
authors.forename: J N
authors.initials: JN
authors.lastname: Moore
authors.forename: K W
authors.initials: KW
authors.lastname: Prasse
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology / Q000662:veterinary; D001794:Blood Pressure / Q000502:physiology*; D002196:Capillaries / Q000502:physiology*; D005534:Foot Diseases / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D005552:Forelimb; D006734:Horse Diseases / Q000209:etiology / Q000503:physiopathology*; D006736:Horses; D007441:Intubation, Gastrointestinal / Q000662:veterinary; D013213:Starch / Q000008:administration & dosage; D014690:Venous Pressure / Q000502:physiology
chemical_list: D013213:Starch