title: [Acute hepatitis and pneumonitis associated with nitrofurantoin].
abstract: Nitrofurantoin is widely used in the prophylaxis and treatment of urinary tract infections. Most untoward side-effects are mild and due to gastrointestinal intolerance. More severe side-effects consist of acute and chronic pulmonary reactions, liver damage, blood dyscrasias and peripheral neuropathy. Nitrofurantoin is a rare cause of hepatic injury, with a spectrum of toxic reactions ranging from acute, self-limited, hepatocellular or cholestatic injury to chronic active hepatitis. We present a case of acute hepatic injury and pneumonitis related to nitrofurantoin. When this drug is given periodic clinical and laboratory monitoring is important.
authors.affiliation: Dept. of Medicine, Zevulun Clinic, Kiryat Motzkin.
authors.forename: A
authors.initials: A
authors.lastname: Kursbaum
authors.forename: E
authors.initials: E
authors.lastname: Rottenstreich
mesh_terms: D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D009582:Nitrofurantoin / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
chemical_list: D009582:Nitrofurantoin