title: Cross resistance between oxytetracycline and oxolinic acid in Aeromonas salmonicida associated with alterations in outer membrane proteins.
abstract: Oxytetracycline resistant mutants of Aeromonas salmonicida isolated from mutation frequency experiments showed decreased susceptibility to oxolinic acid. Outer membrane preparations of these resistant mutant strains revealed a major protein, with a molecular mass of approximately 37 kDa, which was not present in significant quantities in the parent strain.
authors.affiliation: Department of Bacteriology, University of Edinburgh, Medical School, U.K.
authors.forename: A C
authors.initials: AC
authors.lastname: Barnes
authors.forename: C S
authors.initials: CS
authors.lastname: Lewin
authors.forename: T S
authors.initials: TS
authors.lastname: Hastings
authors.forename: S G
authors.initials: SG
authors.lastname: Amyes
mesh_terms: D000333:Aeromonas / Q000187:drug effects* / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010093:Oxolinic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000235:genetics
chemical_list: D001425:Bacterial Outer Membrane Proteins; D010093:Oxolinic Acid; D010118:Oxytetracycline