title: [Rupture of a healthy uterus in a prostaglandin-induced abortion in the second trimester].
abstract: The authors report one case of uterine rupture in a non scarred uterus when an analogue of prostaglandin E2 was being transfused. It was Sulprostone used to terminate a pregnancy because of fetal death in utero after 27 weeks of amenorrhea. This case history and an analysis of the literature makes it possible to point out the need to reach the diagnosis before signs become too severe and to show that pharmacological knowledge of the drug has to be improved as well as the ways of administering prostaglandin analogue. This is to be conducted together with improving the ways of terminating pregnancies in the second trimester. It shows that mechanical accidents can occur even where there are no obvious risk factors. In this case, pain continued from the time of the rupture under epidural anaesthesia. The physiopathology is reviewed. Finally, conservative treatment of the uterus should be carried out whenever possible in order to allow a new pregnancy to occur and to lessen the morbidity of the operation.
authors.affiliation: Clinique Universitaire de Gynécologie-Obstétrique, Hôpital Saint-Antoine, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Larue
authors.forename: L
authors.initials: L
authors.lastname: Marpeau
authors.forename: M
authors.initials: M
authors.lastname: Percque
authors.forename: J
authors.initials: J
authors.lastname: Castiel
authors.forename: X
authors.initials: X
authors.lastname: Guettier
authors.forename: P
authors.initials: P
authors.lastname: Maghioracos
authors.forename: J
authors.initials: J
authors.lastname: Barrat
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects; D000032:Abortion, Therapeutic / Q000009:adverse effects* / Q000379:methods; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005313:Fetal Death / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D014463:Ultrasonography; D014597:Uterine Rupture / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; C016767:sulprostone; D015232:Dinoprostone
vernacular_title: Rupture d'un utérus sain lors d'une interruption de grossesse par prostaglandines au deuxième trimestre.