Effect of prolactin (PRL) on lipoprotein lipase (LPL) activity in the rat fetal liver.
In order to clarify the possible involvement of PRL in the regulation of lipid metabolism, the influence of PRL on the levels of LPL activity in rat fetal liver was investigated. Rat fetuses at 18th day of gestation in one uterine horn were injected with o-PRL while those in the opposite horn with saline. Forty-eight hr later, the livers were removed from the fetuses, homogenized, defatted, dried overnight, and further homogenized to the enzyme suspension. The measurement of LPL activity in these suspensions revealed that LPL activity in the fetal liver treated with o-PRL was significantly higher than that of control. LPL activities in the rat fetal liver gradually increased until the time of birth as the gestation proceeded. These results suggest that PRL may be one of the factors regulating fetal lipid metabolism.
Machida
T
T
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
Taga
M
M
Minaguchi
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development; D005333:Fetus; D066298:In Vitro Techniques; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats
D011388:Prolactin; D008071:Lipoprotein Lipase