title: [Cerebral aminopeptidase activity: effect of the administration of imipramine].
abstract: Imipramine is widely accepted as an effective antidepressant treatment. In this paper, changes in Lys- and Leu-aminopeptidase activities in several rat brain regions after imipramine treatment are described. Decreases of Lys-aminopeptidase activity in the olphactory bulbus, cerebellum, hypothalamus and pituitary gland were observed. In the same way, there were a decreases in Leu-aminopeptidase activity in the parietal and occipital cortices, cerebellum thalamus, hypothalamus and pituitary gland. It is suggested that these enzyme activities play a part in the imipramine action mechanism, possibly by regulating the activity of several neuroactive peptides.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao.
authors.forename: J M
authors.initials: JM
authors.lastname: de Gandarias
authors.forename: J
authors.initials: J
authors.lastname: Irazusta
authors.forename: E
authors.initials: E
authors.lastname: Echecarría
authors.forename: J
authors.initials: J
authors.lastname: Múgica
authors.forename: L
authors.initials: L
authors.lastname: Casis
mesh_terms: D000626:Aminopeptidases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D007099:Imipramine / Q000494:pharmacology*; D007931:Leucyl Aminopeptidase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D007099:Imipramine
vernacular_title: Actividad aminopeptidásica cerebral: efecto de la administración de imipramina.