[Persistence of the influenza virus in children with congenital CNS pathology].
Sick infants born to mothers who experienced influenza during pregnancy were examined. The cerebrospinal fluid, serum and blood cells were collected from such children with signs of congenital immune deficiency and progressive pathology of the central nervous system. None of the specimens yielded infectious influenza virus, but by means of molecular hybridization virus-specific genetic sequences were found in small amounts in the cerebrospinal fluid and serum and in high concentrations in blood cells. Persistence of genes NP, M and H1 of influenza A/H1N1 virus was observed in the blood cells of one infant for 83 days (the observation period). At the same time, the lack of antibodies to viral M protein in serum of this baby was demonstrated by the immune blotting method.
Zuev
V A
VA
Tentsov
Iu Iu
IuIu
Shevchenko
A M
AM
Rzhaninova
A A
AA
Nefedova
N B
NB
Ignatova
N G
NG
Bukrinskaia
A G
AG
D000914:Antibodies, Viral / Q000097:blood; D002493:Central Nervous System Diseases / Q000151:congenital / Q000276:immunology / Q000382:microbiology*; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007251:Influenza, Human / Q000382:microbiology; D008297:Male; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics
D000914:Antibodies, Viral; D004279:DNA, Viral; D012367:RNA, Viral
Persistentsiia virusa grippa u deteĭ s vrozhdennoĭ patologieĭ TsNS.