title: Radiolabeling of a monoclonal antibody with N-succinimidyl para-[77Br]bromobenzoate.
abstract: A preliminary study involving the radiolabeling of an anti-melanoma antibody through conjugation of a radiobrominated small molecule, N-succinimidyl para-[77Br]bromobenzoate, has been accomplished in 22% overall yield when no-carrier-added radiobromine was employed. In vitro analyses demonstrated that the radiobrominated antibody was immunocompetent, retaining 80% of the unlabeled antibody immunoreactivity.
authors.forename: D S
authors.initials: DS
authors.lastname: Wilbur
authors.forename: M D
authors.initials: MD
authors.lastname: Hylarides
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry*; D001967:Bromine Radioisotopes; D006801:Humans; D007553:Isotope Labeling
chemical_list: D000911:Antibodies, Monoclonal; D001967:Bromine Radioisotopes