title: MRI contrast enhancement by MnTPPS of experimental brain tumours in rats.
abstract: In the experimental F98 rat glioma model the nuclear magnetic resonance contrast agent MnTPPS was used to increase the contrast between tumour and peritumourous brain tissue. By evaluating pre- and postcontrast CPMG echo trains after different dose and circulation times of MnTPPS, the transverse relaxation time T2, the magnetization extrapolated to the time zero M (0), and the contrast ratio Rc of the magnetizations in neoplastic and normal tissues were determined. According to these data a maximum contrast is obtained a few hours after injection of 0.25 mmol MnTPPS/kg bw, using spin echo pulse sequences with short repetition times TR (1,100 ms), and short spin echo time TE (25 ms).
authors.affiliation: Max-Planck-Institut für neurologische Forschung, Abteilung für experimentelle Neurologie, Cologne, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Bockhorst
authors.forename: M
authors.initials: M
authors.lastname: Hoehn-Berlage
authors.forename: M
authors.initials: M
authors.lastname: Kocher
authors.forename: K A
authors.initials: KA
authors.lastname: Hossmann
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005910:Glioma / Q000175:diagnosis*; D007089:Image Enhancement; D009682:Magnetic Resonance Spectroscopy; D008665:Metalloporphyrins; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D003287:Contrast Media; D008665:Metalloporphyrins; C056661:manganese(III)tetraphenylporphine sulfonate