[Influences of menopause and oophorectomy on bone metabolism and spinal bone mineral content].
The present study was performed on bone metabolism and spinal bone mineral content (BMC) in 3 groups of age- and body size-matched subjects: Thirty-three postmenopausal subjects, 37 oophorectomized (OPX) subjects and 22 premenopausal subjects. Serum levels of Alp and osteocalcin (OC) as indices of bone formation, U-Ca/cr and U-hydroxyproline (Hpr)/cr as indices of bone resorption, and Ca-regulating hormones, M-PTH, calcitonin (CT) and 1,25(OH)2D; were measured and spinal BMC was determined by QCT. Alp and OC levels were slightly higher in the postmenopausal group than in the OPX group and, in contrast, U-Ca/cr and U-Hpr/cr were slightly higher in the latter. The M-PTH level was slightly higher in the latter, and the CT level in the former. There was no difference in the 1,25(OH)2D level between two groups. For BMC, there was no difference between the two groups. The above results corresponded to the previously reported significant reductions in sex steroids. OPX seemed to affect bone metabolism more than menopause, there was no specific influence of OPX on spinal BMC as compared with QCT findings in postmenopausal subjects. Our previous study and the present study demonstrated that, at an interval of about 3 years after menopause or OPX, the endocrine system and bone metabolism tended to be more affected by OPX. However, BMC did not reflect any influence of OPX, or of menopause. There was no clear clinical difference between postmenopausal subjects and the OPX subjects with regard to the osteoporotic condition.
Ohta
H
H
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo.
Suda
Y
Y
Makita
K
K
Nozawa
S
S
Nemoto
K
K
D000469:Alkaline Phosphatase / Q000378:metabolism; D000735:Androstenedione / Q000378:metabolism; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D004970:Estrone / Q000378:metabolism; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D010052:Ovariectomy; D010758:Phosphorus / Q000378:metabolism; D013131:Spine / Q000378:metabolism*
D015675:Osteocalcin; D010758:Phosphorus; D004970:Estrone; D000735:Androstenedione; D000469:Alkaline Phosphatase; D002118:Calcium