Aerosol propellant interference with clinical mass spectrometers.
Metered dose inhalers containing halogenated propellants may interfere with mass spectrometer quantitation of halogenated inhalation anesthetics. We identify the propellant(s) in a commercially available metered dose inhaler that caused erroneous mass spectrometer readings. In addition, we identify the causes of different types of interference in different mass spectrometers.
Kharasch
E D
ED
Department of Anesthesiology, University of Washington, Seattle 98195.
Sivarajan
M
M
D000335:Aerosol Propellants / Q000032:analysis*; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000032:analysis*; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000032:analysis; D004737:Enflurane / Q000032:analysis; D007530:Isoflurane / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods
D000335:Aerosol Propellants; D000777:Anesthetics; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; C007783:Freon 114; D004737:Enflurane; C005848:trichlorofluoromethane; D007530:Isoflurane; C007782:dichlorodifluoromethane