Developing nonsteroidal anti-inflammatory drugs (NSAIDs) with decreased gastrointestinal (GI) toxicity.
NSAID-induced gastropathy is an important iatrogenic disorder that must be addressed in the development of NSAIDs. A scheme for clinical evaluation is described and salsalate is discussed as a prototype.
Goldlust
B
B
Clinical Research, 3M Pharmaceuticals, St. Paul, MN 55144.
Doucette
M
M
Verduyn
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000633:toxicity; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans
D000894:Anti-Inflammatory Agents, Non-Steroidal