title: 24-month follow-up of multiple sclerosis patients treated with cyclophosphamide.
abstract: 15 patients with remitting-progressive multiple sclerosis received a course of intravenous cyclophosphamide followed by a booster dose every 60 days for 2 years. There were no severe short or medium term side effects. Half of the patients presented clinical stabilization and substantially unchanged Kurtzke rating at 2 year follow-up. Since the aim was stabilization only, our findings argue for continuation of the study in young patients with very short shift.
authors.affiliation: Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma.
authors.forename: E
authors.initials: E
authors.lastname: Millefiorini
authors.forename: M
authors.initials: M
authors.lastname: Di Giovanni
authors.forename: S
authors.initials: S
authors.lastname: Bernardi
authors.forename: M G
authors.initials: MG
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Di Giampietro
authors.forename: D
authors.initials: D
authors.lastname: Gambi
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012720:Severity of Illness Index
chemical_list: D003520:Cyclophosphamide