title: [Rhabdomyolysis due to paraphenylenediamine (hair dye)--report of an autopsy case].
abstract: An autopsy case of rhabdomyolysis following homicidal intoxication of paraphenylenediamine was reported and the toxicological mechanism of PPD against skeletal muscles was discussed. The case was a 44 years old, previously healthy male, drinking a beverage containing PPD, prepared for a homicidal use. Total intake of PPD was about 3 g (63 mg/kg). Principal clinical manifestation of the patient was muscle rigor with tenderness, initially developed in the lower extremities and subsequently extending to all over the skeletal muscles. Laboratory examinations disclosed high CPK (137,600), LDH (3895), GOT (3400) and GPT (545), and leukocytosis (26600), indicating massive skeletal muscle necrosis. ECG revealed mild depression of ST junction in the II and aVF leads. Urine showed dark brownish discoloration and diminished in volume subsequently. Scattered necrosis of muscular fibers was observed in a biopsy of the femoral muscles. The consciousness was rather clear during the course. The patient collapsed suddenly and soon died in the course of about 30 hours. Clinically, the cause of death was thought to be acute renal failure due to rhabdomyolysis. Afterwards PPD was detected in the urine obtained in the hospital. Autopsy confirmed the clinical diagnosis: Renal collecting ductules and distal tubules were occluded by dark brownish myoglobin casts and its epithelium massively necrotized; Skeletal muscles showed scatteredly coagulation necrosis and were partially associated with inflammatory cell infiltration.
authors.affiliation: Department of Legal Medicine, Saitama Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Murai
authors.forename: K
authors.initials: K
authors.lastname: Yabe
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Hurukawa
mesh_terms: D000328:Adult; D006202:Hair Dyes / Q000506:poisoning*; D006708:Homicide; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology; D010655:Phenylenediamines / Q000506:poisoning*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D006202:Hair Dyes; D010655:Phenylenediamines; C029728:4-phenylenediamine