title: [Development of the fragments of embryonal spinal cord in a damaged peripheral nerve of a mature animal].
abstract: By means of morphological methods dynamics of the spinal cord development in 14-day-old rat embryos implanted into the sciatic nerve of mature rats have been studied. The implants preserve their viability during 5 months after the operation and their cells continue to differentiate beginning from neuroepithelial cells and neuroblasts up to young and mature neurons with histotypical signs of motoneurons. In 6 h and 1 day after transplantation the neuroepithelial cells continue their mitotic division. In 3 days, however, their mitotic activity decreases essentially and differentiation of neuroblasts begins. In 7 days the implants consist mainly of differentiated neuroblasts and glial cells. As demonstrates electron microscopy, in 30 days after the operation in the implants there is a well developed neuropil, where mature neurons, myelinated axons are situated and synaptic contacts are present.
authors.forename: E S
authors.initials: ES
authors.lastname: Petrova
authors.forename: E I
authors.initials: EI
authors.lastname: Chumasov
mesh_terms: D000367:Age Factors; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004622:Embryo, Mammalian; D016332:Fetal Tissue Transplantation; D005865:Gestational Age; D008854:Microscopy, Electron; D008938:Mitosis / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000473:pathology; D051381:Rats; D012584:Sciatic Nerve / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D013116:Spinal Cord / Q000166:cytology / Q000637:transplantation* / Q000648:ultrastructure
vernacular_title: Razvitie fragmentov émbrional'nogo spinnogo mozga krysy v povrezhdennom perifericheskom nerve vzroslogo zhivotnogo.