[The hemodynamic reactions of hypertension patients taking the calcium antagonists finoptin and korinfar].
As many as 98 patients suffering from essential hypertension (EH) were examined for the effects of verapamil and nifedipine. The hemodynamics and heart contractility were estimated by means of echocardiography on an "Aloka D-280" outfit (Japan). The following parameters of the cardio- and hemodynamics were computed: the stroke and minute blood volumes, cardiac index, mean velocity of ventricular evacuation, performance of the left heart, energy consumption by the myocardium, arterial pressure (systolic, diastolic and mean), total peripheral vascular resistance, ejection fraction, and the rate of circulatory shortening of myocardial fibers. Analysis of the effects of verapamil and nifedipine on the cardio- and hemodynamics in EH patients has demonstrated that in addition to their unidirectional action manifested by a steady hypotensive effect, the drugs under consideration produced an action of different directions as regards certain essential parameters in a considerable number of the patients.
Goloshchapov
O A
OA
Goldabin
V I
VI
Geller
A L
AL
Mashin
A A
AA
D000328:Adult; D004341:Drug Evaluation; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D014700:Verapamil; D009543:Nifedipine
Gemodinamicheskie reaktsii u bol'nykh gipertonicheskoĭ bolezn'iu na priem antagonistov kal'tsiia finoptina i korinfara.