title: Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid.
abstract: The nucleotide sequence of the SHV-5 beta-lactamase gene, subcloned from a plasmid of Klebsiella pneumoniae, was determined. The amino acid changes thought to be responsible for the extended substrate profile of SHV-5 are Gly----Ser234 and Glu----Lys235. SHV-5 is identical to SHV-4, except for Leu----Arg201, which accounts for the difference in apparent pI of the two enzymes.
authors.affiliation: Laboratoire de Microbiologie Médicale, Université Paris VI, France.
authors.forename: D
authors.initials: D
authors.lastname: Billot-Klein
authors.forename: L
authors.initials: L
authors.lastname: Gutmann
authors.forename: E
authors.initials: E
authors.lastname: Collatz
mesh_terms: D001483:Base Sequence; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases