Pharmacokinetics of nicotine after application of a 30 cm2 nicotine patch under steady-state conditions.
Transdermal nicotine systems (Nicotinell 30) were applied daily to the skin of healthy nicotine-dependent smokers for 4 days. Blood samples were taken for the measurement of nicotine and cotinine in plasma using capillary gas chromatography with nitrogen detection. The plasma concentration-time profiles of nicotine and cotinine and the pharmacokinetic parameters cmax, tmax, AUC and the elimination half-life were determined under steady-state conditions. Nicotine levels after application of the 30 cm2 patch were in accord with published values for 10, 20 and 2 x 20 cm2 patches. The elimination half-life of nicotine after removal of the patch was longer than reported values obtained after i.v. application.
Caspary
S
S
Abteilung für Klinische Pharmakologie, Universitätsklinik Frankfurt, FRG.
Keller-Stanislawski
B
B
Huber
T
T
Merz
P G
PG
D000279:Administration, Cutaneous; D000328:Adult; D003367:Cotinine / Q000097:blood*; D006207:Half-Life; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012907:Smoking / Q000097:blood / Q000378:metabolism
D009538:Nicotine; D003367:Cotinine