Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin belong to a novel family of actin ADP-ribosylating toxins. ADP-ribosylation of actin inhibits actin polymerization and G-actin-associated ATPase activity. The ADP-form of actin is ADP-ribosylated at a higher rate than actin with bound ATP. ADP-ribosylation of actin is reversible, a reaction, which is accompanied by reconstitution of actin ATPase activity.
Aktories
K
K
Rudolf-Buchheim Institut für Pharmakologie, Universität Giessen.
Geipel
U
U
Wille
M
M
Just
I
I
D000199:Actins / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D001081:Apyrase / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism*; D001905:Botulinum Toxins / Q000378:metabolism*; D003016:Clostridium perfringens / Q000032:analysis*
D000199:Actins; D001427:Bacterial Toxins; D000246:Adenosine Diphosphate Ribose; D001905:Botulinum Toxins; D001081:Apyrase