Modulation of oxytocin and vasopressin release from rat neurosecretosomes: the roles of VIP oxytocin and GABA.
The effects of vasoactive intestinal polypeptide (VIP), of a selective oxytocin antagonist and of GABA on basal and stimulated oxytocin and vasopressin release from isolated neurosecretory endings were investigated. Superfusion of the secretosomes with VIP (10(-7) M) induced an increased basal and stimulated release of both oxytocin and vasopressin. Addition of the oxytocin antagonist induced a decrease of the stimulated oxytocin release as compared to the control which indicated a positive feedback mechanism of oxytocin on oxytocin release. In presence of GABA (1 or 50 microM) no change in basal or stimulated oxytocin and vasopressin release was observed.
Falke
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Sektion Elektronenmikroskopie, Universität Ulm, FRG.
D000818:Animals; D005246:Feedback / Q000502:physiology; D008297:Male; D009411:Nerve Endings / Q000378:metabolism; D009489:Neurosecretion / Q000187:drug effects*; D010121:Oxytocin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D010904:Pituitary Gland, Posterior / Q000294:innervation* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D014667:Vasopressins / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
C055830:KB 5-21; D014667:Vasopressins; D014660:Vasoactive Intestinal Peptide; D010121:Oxytocin; D005680:gamma-Aminobutyric Acid