Pharmacokinetic evaluation of conventional and controlled-release product of naproxen.
The bioavailability and pharmacokinetics of a new controlled-release tablet (CRT) of naproxen (750 mg tablet) have been determined, relative to an equivalent dose of conventional product (CT), by a cross-over study in twenty healthy volunteers. The two dosage forms were bioequivalent in terms of total AUC; however, the Cmax of the controlled-release product was lower, and the Tmax longer than that of the conventional product. The mean residence time and the absorption and elimination half-lives of the CRT were also substantially longer than those of the CT. The pharmacokinetic features offered by the novel formulation suggest that it may be suitable for once-daily dosing.
Palazzini
E
E
Alfa Wassermann S.p.A., Bologna, Italy.
Galli
G
G
Babbini
M
M
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D003692:Delayed-Action Preparations; D009288:Naproxen