Serum glucose after intraperitoneal infusion of 5% dextrose solution.
OBJECTIVE
This study investigated the use of intraperitoneal (IP) glucose infusion as a therapy for hypoglycemia.


METHODS
Randomized, placebo-controlled, crossover design, with each animal serving as its own control.


METHODS
Laboratory investigation.


METHODS
Seven female New Zealand White rabbits with a mean weight of 3.7 kg.


METHODS
Each animal was subjected to three experiments separated by a four-day period. After baseline measurements, the following interventions were undertaken: Control day, no treatment; placebo day, 10 mL/kg 0.9% normal saline solution IP; and treatment day, 10 mL/kg 5% dextrose solution IP.


RESULTS
Serial serum glucose levels were obtained. Compared with control and placebo, the mean absolute serum glucose value of the treatment group was significantly higher beginning at ten minutes after intervention and continuing until conclusion of the study at 30 minutes. For these time points, the mean increase in serum glucose levels (percent change) of the treatment group compared with the control group was as follows: ten minutes, 15.5 mg/dL (0.86 mmol/L) (11%), P less than .01; 15 minutes, 20.6 mg/dL (1.14 mmol/L) (14%), P less than .01; 20 minutes, 36.5 mg/dL (2.03 mmol/L) (26%), P less than .001; and 30 minutes, 34.7 mg/dL (1.93 mmol/L) (24%), P less than .001.


CONCLUSIONS
Glucose instilled into the peritoneal cavity of rabbits is absorbed rapidly into the systemic circulation.
McNamara
R M
RM
Department of Emergency Medicine, Medical College of Pennsylvania, Philadelphia 19129.
Schoffstall
J M
JM
Fuerst
R S
RS
D000042:Absorption; D000818:Animals; D001786:Blood Glucose; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007003:Hypoglycemia / Q000188:drug therapy*; D007263:Infusions, Parenteral; D011817:Rabbits
D001786:Blood Glucose; D005947:Glucose