[Glomerulonephropathy associated with hepatitis B virus (HBV) infection].
Forty-seven renal biopsies of glomerulonephropathy with persistent Australian antigenaemia (HBsAg is mostly positive) were studied with light microscope, electron microscope and direct immunofluorescence. Immunohistochemical method (ABC method) was used to examine HBsAg, HBeAg and HBcAg deposits in renal tissue. In addition 20 cases of idiopathic membranous nephropathy (MN) were studied for comparison. These 47 cases included 19 children and 28 adults. The results indicated that Australian antigens diffusely deposited in glomeruli in 14 cases (29.7%), with HBsAg in 7 cases (50.0%), HBeAg in 13 cases (92.8%) and HBcAg in 2 cases (14.3%). The 14 positive cases included 11 children and 3 adults. The pathologic types were membranous nephropathy in 12 and membranoproliferative glomerulonephritis in 2 cases. The membranous type was characterized by irregular thickening of capillary wall and double contour, bubble-like appearance and spike formation of glomerular basement membrane (GBM); immune complexes and electron dense deposits may be present in different sites of glomeruli. Coarse granular deposits of IgG and C3 along GBM were the principal pattern, but IgA, IgM and C1q were often present. Among the 20 idiopathic MN, 2 were found to have HBeAg deposition along GBM, one was a child and the other an adult IgG, IgA, IgM, C3 and C1q with HBeAg deposits were present in glomeruli.
Zhou
W Z
WZ
Department of Pathological, Beijing Medical University.
Zhang
W L
WL
Geng
L
L
D000328:Adult; D001707:Biopsy, Needle; D002353:Carrier State; D002648:Child; D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis; D006509:Hepatitis B / Q000150:complications*; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D008297:Male
D006511:Hepatitis B Antigens