Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse.
Age-associated changes in DNA methylation of the c-myc gene in liver were compared between humans and mice which have large differences in aging rate. Although the overall methylation profiles of the gene and their age-related changes were found to be similar, the rate of change was much slower in humans than in mice. It suggests that the age-associated alteration of c-myc gene methylation is closely related to biological aging rather than to chronological aging.
Ono
T
T
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Yamamoto
S
S
Kurishita
A
A
Yamamoto
K
K
Yamamoto
Y
Y
Ujeno
Y
Y
Sagisaka
K
K
Fukui
Y
Y
Miyamoto
M
M
Tawa
R
R
D000375:Aging; D000818:Animals; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D016259:Genes, myc; D005865:Gestational Age; D006801:Humans; D008099:Liver / Q000196:embryology / Q000254:growth & development*; D008745:Methylation; D051379:Mice; D008810:Mice, Inbred C57BL; D015183:Restriction Mapping
D004247:DNA