MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course.
In rabbits, 3 mg/kg Ro 19-6327 p.o., induced complete monoamine oxidase type B (MAO-B) inhibition in striatum, cerebral cortex, liver and platelets for about 12 h. In healthy human volunteers complete inhibition of platelet MAO was obtained with only 5 mg Ro 19-6327. After 40 and 200 mg Ro 19-6327 the duration of complete MAO-B inhibition was prolonged to 12 and 24 hours, respectively. Changes in brain MAO-B in humans after Ro 19-6327 are likely to be faithfully reflected by platelet MAO activity.
Kettler
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Pharmaceutical Department F. Hoffmann-La Roche Ltd. Basel, Switzerland.
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Dingemanse
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Da Prada
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D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000097:blood / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010848:Picolinic Acids / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; C059303:lazabemide; D008995:Monoamine Oxidase