Auto-immune spondylodiscitis associated with collagen induced arthritis in rats: high field MRI findings.
The spinal involvement of the tail was studied in Wistar Furth rats immunized with bovine native type II collagen. Focal caudal autoimmune spondylodiscitis occurred 5 weeks after sensitization, as assessed histopathologically. High field Magnetic Resonance Imaging (MRI) was useful in depicting these caudal abnormalities that were related to juxta-diskal enthesitis. The occurrence of such inflammatory enthesopathies could serve as an experimental approach for physiopathological and therapeutical studies of spondylarthropathies.
Gillet
P
P
Department of Pharmacology, URA CNRS 1288, Université de Nancy, Vandoeuvre Les Nancy.
Fener
P
P
Escanyé
J M
JM
Walker
P
P
Bannwarth
B
B
Jouzeau
J Y
JY
Drelon
E
E
Floquet
J
J
Netter
P
P
Robert
J
J
D000818:Animals; D001169:Arthritis, Experimental / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D001327:Autoimmune Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D003094:Collagen; D015299:Discitis / Q000209:etiology / Q000473:pathology*; D005260:Female; D008279:Magnetic Resonance Imaging; D011859:Radiography; D051381:Rats; D011920:Rats, Inbred WF; D013623:Tail / Q000000981:diagnostic imaging / Q000473:pathology
D003094:Collagen