Endothelium-dependent relaxation induced by sodium fluoride in the rabbit ear artery.
Sodium fluoride (NaF) produced concentration-dependent relaxation of isolated rabbit ear artery precontracted with norepinephrine. In contrast, an arterial preparation with the endothelium rubbed off did not relax, but contracted in response to NaF. NaF-induced relaxation was not influenced by indomethacin but was inhibited by methylene blue or NG-monomethyl-L-arginine. The results indicate that NaF relaxes the artery by releasing a so-called EDRF.
Tsuru
H
H
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
D000818:Animals; D001158:Arteries / Q000378:metabolism*; D004423:Ear / Q000098:blood supply*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D011817:Rabbits; D012969:Sodium Fluoride / Q000494:pharmacology*
D009569:Nitric Oxide; D012969:Sodium Fluoride