A new intracellular flush solution improves renal transplant preservation.
A new renal preservation flush solution (PB-2) has been developed to minimize the ischemic injury processes that occur during hypothermic storage and reperfusion and that can decrease renal viability and survival. Development of the new formulation took into account the intracellular and biological interactions that occur pre- and post-transplantation. PB-2 was compared with the conventional standardized Collins-2 flush solution in the preservation of autografts in dogs and was found to provide significantly improved renal recovery, viability, and survival. Studies to test the new solution in human renal allograft transplant preservation are planned.
Bretan
P N
PN
Harbor/UCLA Transplant Service, University of California, Los Angeles.
Novick
A C
AC
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage; D004285:Dogs; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology* / Q000379:methods; D009926:Organ Preservation / Q000379:methods*; D015427:Reperfusion Injury / Q000378:metabolism; D012996:Solutions
D003524:Cyclosporins; D012996:Solutions