[The ligand-dependent phosphorylation of epidermal growth factor receptors and the production of a secreted form of the receptor by cell strains of A-431 epidermoid carcinoma].
Primary reactions on the addition of the epidermal growth factor (EGF) were investigated for the strains of A-431 cells, resistant to the antiproliferative effect of EGF. In spite of differences of EGF reception in the obtained strains, the EGF receptors in membrane preparations of these strains maintain the phosphorylating ability after addition of EGF. The rate of internalization of 125I-EGF in normal and resistant cells is the same. The production of a secreted fragment of the EGF receptor in resistant cells is lower than in normal ones. Questions of regulation of production of the normal receptor and of its shortened secreted fragment are discussed.
Sorokin
A B
AB
Gudkova
D A
DA
Kudriavtseva
N V
NV
Nikol'skiĭ
N N
NN
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004351:Drug Resistance; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008024:Ligands; D010766:Phosphorylation / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D007457:Iodine Radioisotopes; D008024:Ligands; D004815:Epidermal Growth Factor; D066246:ErbB Receptors
Ligandzavisimoe fosforilirovanie retseptorov épidermal'nogo faktora rosta i produktsiia sekretiruemoĭ formy retseptora kletochnymi shtammami épidermoidnoĭ kartsinomy A-431.