Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels.
In a double-blind study the effects of troxerutine were assessed in patients with chronic venous insufficiency. The aim of this clinical pharmacological research was to evaluate, after a single oral dose: haemocoagulative and fibrinolytic balance, haemorheological changes and venous function. Correlation between such changes and simultanously assayed plasma drug levels was evaluated. The data obtained seems to give to troxerutine a more enlarged pharmacological characterization, especially regarding its demonstrated profibrinolytic and rheological activities. The maximal pharmacodynamic effects appeared simultaneous with the plasma drug peak.
Auteri
A
A
Institute of Medical Pathology, University of Siena, Italy.
Blardi
P
P
Frigerio
C
C
de Lillo
L
L
di Perri
T
T
D000328:Adult; D000925:Anticoagulants / Q000097:blood / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D013056:Spectrophotometry, Ultraviolet; D014652:Vascular Diseases / Q000188:drug therapy*
D000925:Anticoagulants; D006896:Hydroxyethylrutoside; C005865:troxerutin