title: MR imaging of experimental and clinical thrombi at 1.5 T.
abstract: We have previously reported that the T1 and T2 of experimental clots at 0.47 T varies considerably depending upon the method used in their preparation. However, these studies, while relevant to midfield imaging, may not reflect accurately the behavior of such thrombi at higher field strengths. Accordingly, we studied the T1 and T2 at 1.5 T of experimental thrombi prepared by several methods and compared these results with the relaxation times of clinical deep venous thrombi measured in situ in patients. The relationship between the T2 values for the different clot preparation methods was different at 1.5 T than at 0.47 T. The combined use of thrombin and epsilon-amino caproic acid produced thrombi with T1 and T2 indistinguishable from clinical deep venous thrombi.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: J C
authors.initials: JC
authors.lastname: Bass
authors.forename: L W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: H D
authors.initials: HD
authors.lastname: Sostman
mesh_terms: D015119:Aminocaproic Acid / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods; D012044:Regression Analysis; D013053:Spectrophotometry; D013917:Thrombin / Q000032:analysis; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D014867:Water / Q000032:analysis
chemical_list: D014867:Water; D013917:Thrombin; D015119:Aminocaproic Acid