Acarbose treatment and diabetic nephropathy in the Cohen diabetic rat.
Groups of Cohen diabetic rats, aged 30 days were treated with Acarbose (40 mg per 100 g sucrose diet) for 3, 5 and 7 months. Siblings of the same sex were used as controls and fed the sucrose diet alone. The dose of Acarbose was adjusted in a preliminary study and found to be tolerated by the animals. Acarbose treatment resulted in a significant reduction of the 2 hr postprandial blood glucose. No elevation of the plasma insulin was noted. A significant decreased incidence and severity of glomerulosclerosis was not in the 3 months Acarbose treated groups (P less than 0.05) and in the 5 and 7 months (P less than 0.01) in comparison with the controls. In the 7 months Acarbose treated group the longevity was significantly longer than in the control (P less than 0.05). In the 3 and 5 months groups, increased longevity was not apparent as the animals were sacrificed before having the opportunity to manifest the difference.
Cohen
A M
AM
Isotope Laboratory for Endocrine Research, Hadassah University Hospital, Jerusalem, Israel.
Rosenmann
E
E
D020909:Acarbose; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015994:Incidence; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000494:pharmacology / Q000627:therapeutic use*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014312:Trisaccharides; D020909:Acarbose