A preliminary study of the ocular hypotensive effects of bromocriptine in diabetic patients with autonomic neuropathy.
The effect of bromocriptine on intraocular pressure has been investigated in a group of 8 diabetic patients with autonomic neuropathy, to test the hypothesis that bromocriptine exerts its ocular hypotensive action through presynaptic dopamine receptors. Bromocriptine eye drops (0.025%) produced a significant fall in intraocular pressure in a control group of 8 matched normal volunteers, but this effect was not seen in the eyes of the diabetic patients. These results are consistent with a presynaptic site of action of bromocriptine.
al-Sereiti
M R
MR
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Turner
P
P
Gale
E A
EA
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011954:Receptors, Dopamine / Q000187:drug effects
D009883:Ophthalmic Solutions; D011954:Receptors, Dopamine; D001971:Bromocriptine