title: [Pathogenesis of alcohol-induced hyperlipidemia: case report of hypertriglyceridemia over 10,000 mg%].
abstract: A 53-year old woman developed excessive hypertriglyceridemia (greater than 10,000 mg/dl) with features of toxic liver damage after prolonged ethanol ingestion. Lipoprotein-lipase-activity was not decreased, apolipoprotein-C-II analysis, as shown by gel-electrophoresis, revealed a regular pattern. Treatment with parenteral nutrition and abstinence of ethanol resulted in a complete normalization of plasma triglycerides after transient remnant-hyperlipidemia. Decrease of triglycerides was accompanied by declining liver enzyme activities. As suggested by unimpaired activity of lipolysis, the extent of hypertriglyceridemia may be explained by a reversible receptor mediated defect of hepatic catabolism, aggravated by hepatic overproduction of triglyceride-rich-particles. Although receptor dysfunction is not yet understood, the transient appearance of remnant particles may be a helpful criteria in diagnosis of ethanol induced hypertriglyceridemia.
authors.affiliation: Arbeitsbereich Klinische Diätetik und Abteilung Gastroenterologie, Zentrum Innere Medizin Medizinischen Hochschule Hannover.
authors.forename: A
authors.initials: A
authors.lastname: Rahn
authors.forename: A
authors.initials: A
authors.lastname: Beigel
authors.forename: F W
authors.initials: FW
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Canzler
mesh_terms: D000437:Alcoholism / Q000097:blood* / Q000150:complications; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
vernacular_title: Pathogenese der alkoholinduzierten Hpyerlipidämie: Fallstudie einer Hypertriglyceridämie über 10,000 mg%.