title: Assignment of human prochymosin pseudogene to chromosome 1.
abstract: Chymosin is an extremely specific aspartatic protease responsible for milk coagulation. Chymosin is expressed in a number of mammalian offspring, yet its presence in the gastric tissue of human infants remains a matter of controversy. In any event, the human genome contains chymosin-related sequences that probably represent a pseudogene. Using DNA obtained from human x hamster somatic cell hybrids as the template and polymerase chain reaction, we have mapped the human prochymosin pseudogene to chromosome 1.
authors.affiliation: Department of Biochemistry and Biotechnology, University of Kuopio, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Kolmer
authors.forename: T
authors.initials: T
authors.lastname: Ord
authors.forename: L
authors.initials: L
authors.lastname: Alhonen
authors.forename: J M
authors.initials: JM
authors.lastname: Hyttinen
authors.forename: M
authors.initials: M
authors.lastname: Saarma
authors.forename: R
authors.initials: R
authors.lastname: Villems
authors.forename: J
authors.initials: J
authors.lastname: Jänne
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D012085:Chymosin / Q000235:genetics*; D006224:Cricetinae; D004247:DNA; D004792:Enzyme Precursors / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011544:Pseudogenes
chemical_list: D004792:Enzyme Precursors; D004247:DNA; C032443:prorennin; D012085:Chymosin