title: Early pathomorphological changes and intracranial volume-pressure: relations following the experimental sagittal sinus occlusion.
abstract: Saggital sinus occlusion was produced in cats. The intracranial volume-pressure relations were studied using the lumbar infusion tests. Right after occlusion ICP rised from 7.1 +/- 1.8 to 12.4 +/- 4.1 mmHg. The values of outflow resistance and volume-pressure response increased also and remained significantly unchanged with only slight decrease of the volume-pressure response. The morphometric study of the surface veins showed the dilatation of the veins draining to the occluded saggital sinus for about 10-20%. No signs of the blood-brain barrier disruption were observed.
authors.affiliation: Department of Neurosurgery, Medical Research Centre, Polish Academy of Sciences, Warsaw.
authors.forename: K
authors.initials: K
authors.lastname: Tychmanowicz
authors.forename: Z
authors.initials: Z
authors.lastname: Czernicki
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
authors.forename: G
authors.initials: G
authors.lastname: Pawłowski
authors.forename: G
authors.initials: G
authors.lastname: Uchman
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002415:Cats; D002555:Cerebrospinal Fluid / Q000502:physiology; D003392:Cranial Sinuses; D005074:Evoked Potentials, Visual; D007427:Intracranial Pressure; D011312:Pressure; D012851:Sinus Thrombosis, Intracranial / Q000473:pathology* / Q000503:physiopathology; D014664:Vasodilation