Acceleration of chromosome aberrations in senescence-accelerated strains of mice.
Age-related changes in the frequency of chromosome aberrations were examined using bone marrow cells of senescence-accelerated strains of mice (SAM). An accelerated senescence-prone strain, SAM-P/1, showed a striking increase in the frequency of chromosome aberrations, from age 3 to 8 months, whereas an accelerated senescence-resistant strain, SAM-R/1, at the same ages showed only a slight increase. Both these strains were derived from the same ancestral strain (AKR/J). The rate of increase of chromosome aberration frequency paralleled the advancement of senescence in both strains. These observations suggest that there are genetic factors which closely relate to chromosomal instability and acceleration of the senescence processes.
Nisitani
S
S
Department of Senescence Biology, Kyoto University, Japan.
Hosokawa
M
M
Sasaki
M S
MS
Yasuoka
K
K
Naiki
H
H
Matsushita
T
T
Takeda
T
T
D000375:Aging / Q000235:genetics*; D000818:Animals; D001853:Bone Marrow / Q000254:growth & development; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D007621:Karyotyping; D008017:Life Expectancy; D051379:Mice; D008805:Mice, Inbred A / Q000254:growth & development; D008806:Mice, Inbred AKR / Q000254:growth & development; D008810:Mice, Inbred C57BL / Q000254:growth & development; D008817:Mice, Mutant Strains / Q000254:growth & development*