title: A sterile male with 45,X0 and a Y;22 translocation.
abstract: Cytogenetic analysis of a 20-year-old sterile male revealed a 45,X0 karyotype with no evidence for Y-chromosomal material on any of the chromosomes analysed by Q-, G- and C-banding. DNA analysis with 17 different Y chromosome-derived probes revealed the presence of Yp DNA sequences in the patient's genome. In situ hybridization with the Yp-derived probe pJA36B disclosed a translocation of Y-chromosomal material onto the short arm of a chromosome 22.
authors.affiliation: Institut für Humangenetik, Universität Göttingen, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Arnemann
authors.forename: S
authors.initials: S
authors.lastname: Schnittger
authors.forename: G K
authors.initials: GK
authors.lastname: Hinkel
authors.forename: E
authors.initials: E
authors.lastname: Tolkendorf
authors.forename: J
authors.initials: J
authors.lastname: Schmidtke
authors.forename: I
authors.initials: I
authors.lastname: Hansmann
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002892:Chromosomes, Human, Pair 22; D015342:DNA Probes; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic; D014998:Y Chromosome
chemical_list: D015342:DNA Probes