title: A state space model of local energy exchange and circulatory control.
abstract: Based on the assumption that the maintenance of the energy content of the living tissue was the goal of the control, a generalized model of the regulation of local circulation was developed. The goodness of the model realised on a microcomputer was verified by the good fits of simulation with various physiological reactions obtained in animal experiments that were performed in cats anaesthetized with alpha-chloralose (50 mg/kg, i.v.). The reactions were elicited by tilting the animal (45 degrees head up) and by obstructing hindlimb blood flow by means of inflation of a pressure cuff. The appropriateness of energetic considerations of the hypothesis and the properness of the construction of the model was confirmed also by the similarity of the simulated static and dynamic pressure-flow and flow-temperature characteristics, respectively, with those obtained in animal experiments reported in the literature. The performance of the model suggests that the well-known regulatory phenomena of the local circulation are the results of a set point-free control system.
authors.affiliation: National Institute of Neurosurgery, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Füzes
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004735:Energy Transfer; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D013696:Temperature