title: A pilot study of neoadjuvant chemotherapy with 5-fluorouracil and cisplatin with surgical resection and postoperative radiation therapy and/or chemotherapy in adenocarcinoma of the esophagus.
abstract: Fifteen patients with potentially resectable adenocarcinoma of the esophagus were treated with two cycles of preoperative chemotherapy with 5-fluorouracil (5-FU) and cisplatin (DDP). Response to chemotherapy was evaluated by comparative barium swallow, computerized chest tomography, esophagoscopy, and change in clinical symptomatology. Eleven patients (73%) were resected, two (13%) were explored and found inoperable, and two (13%) were not subjected to surgery (one because of death related to toxicity and one due to progressive disease). Ten of eleven patients (91%) had gross residual tumor. One patient (9%) had residual microscopic disease only. One patient (7%) had complete clinical responses (CCR), five (33%) had partial clinical response (PCR), and nine (60%) had no response (NR). Five of 15 patients (or 45% of resected patients) remain free of disease. Median survival time was 18.47 months for all patients and 23.83 months for resected patients.
authors.affiliation: Medical Services Massachusetts General Hospital, Harvard Medical School, Boston.
authors.forename: R W
authors.initials: RW
authors.lastname: Carey
authors.forename: A D
authors.initials: AD
authors.lastname: Hilgenberg
authors.forename: N C
authors.initials: NC
authors.lastname: Choi
authors.forename: D J
authors.initials: DJ
authors.lastname: Mathisen
authors.forename: H C
authors.initials: HC
authors.lastname: Grillo
authors.forename: J C
authors.initials: JC
authors.lastname: Wain
authors.forename: D L
authors.initials: DL
authors.lastname: Logan
authors.forename: C
authors.initials: C
authors.lastname: Bromberg
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011184:Postoperative Period; D016019:Survival Analysis
chemical_list: D002945:Cisplatin; D005472:Fluorouracil