title: Effect of gammahydroxybutyrate on intracranial pressure, mean systemic arterial pressure and cerebral perfusion pressure in experimentally induced brain oedema of the rat.
abstract: The effect of gammahydroxybutyrate (GHB) on ICP, systemic arterial pressure and cerebral perfusion pressure in the experimentally induced brain oedema of the rat was examined. 400 mg/kg GHB reduced significantly ICP (11.74 +/- 1.20 mm Hg; control: 16.20 +/- 8.89 mm Hg; p less than 0.01) while increasing mean systemic arterial pressure (109.89 +/- 6.35 mm Hg; control: 89.65 +/- 4.22 mm Hg; p less than 0.05) and cerebral perfusion pressure (98.11 +/- 6.79 mm Hg; control: 73.84 +/- 5.25 mm Hg; p less than 0.02). In the dose-effect curve 200 mg/kg GHB show an increase in mean systemic arterial pressure from 89.60 +/- 9.35 mm Hg to 97.60 +/- 3.48 mm Hg (p less than 0.02) and 400 mg/kg GHB to 108.00 +/- 5.20 mm Hg (p less than 0.001) mean systemic arterial pressure. Thus, the decrease in intracranial pressure is not due to a reduction in the mean systemic arterial pressure, but GHB does reduce the ICP while increasing mean systemic arterial pressure and cerebral perfusion pressure. GHB may be a useful adjunct to neurosurgical therapy in controlling elevated ICP.
authors.affiliation: Department of Neurosurgery, University of Innsbruck, Austria.
authors.forename: C A
authors.initials: CA
authors.lastname: Plangger
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000494:pharmacology*
chemical_list: D012978:Sodium Oxybate