Rhabdomyosarcomatous differentiation in a neuroblastoma: a potential pitfall in the cytologic diagnosis of small round-cell tumors of childhood.
Rhabdomyoblasts demonstrating immunoreactivity for muscle-specific actin, desmin, and myoglobin were identified in smears obtained by aspiration from a large retroperitoneal mass in a 14-mo-old girl. Following a tentative diagnosis of a rhabdomyogenous neoplasm, retroperitoneal exploration and adrenalectomy demonstrated a stromal poor neuroblastoma with extensive rhabdomyogenous differentiation. The presence of a subpopulation of rhabdomyoblasts was not diagnostic of rhabdomyosarcoma when obtained by fine-needle aspiration from a retroperitoneal tumor composed predominantly of primitive small round cells.
Layfield
L J
LJ
Department of Pathology, University of California, Los Angeles 90024-1732.
Glasgow
B J
BJ
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014408:Biomarkers, Tumor; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000473:pathology*
D014408:Biomarkers, Tumor