title: The effects of dorsal noradrenergic bundle lesions on spatial learning, locomotor activity, and reaction to novelty.
abstract: The dorsal noradrenergic bundle (DNB) of male Wistar rats was lesioned bilaterally using intracerebral injections of 6-hydroxydopamine neurotoxin. Some of the rats were trained in a water maze using an "alternation" strategy, where the two positions of the hidden platform in the pool were changed between successive trials in the daily tests, and other rats in a water maze, where the temperature of the water was lowered to about 11 degrees C. The rats trained in the cold-water maze were also tested in open-field and saccharin neophobia tests. No differences were found between the two groups in learning of water maze tasks or in locomotor activity in the open-field tests. However, the saccharin neophobia test revealed an increased neophobia in the DNB-lesioned rats.
authors.affiliation: Department of Neurology, University of Kuopio, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Valjakka
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
authors.forename: J
authors.initials: J
authors.lastname: Sirviö
authors.forename: S
authors.initials: S
authors.lastname: Nieminen
authors.forename: M
authors.initials: M
authors.lastname: Airaksinen
authors.forename: R
authors.initials: R
authors.lastname: Miettinen
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D004924:Escape Reaction / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000502:physiology
chemical_list: D009638:Norepinephrine