Modeling the hemodynamic response to dopamine in acute heart failure.
A descriptive incremental nonlinear single-input-multiple-output (SIMO) model of the hemodynamic response [cardiac output (CO) and mean aortic pressure (MAP)] to the inotropic drug dopamine in acute ischemic heart failure was constructed to facilitate the design of closed-loop control systems. The structure of the CO component of the model is a first-order system with a sigmoidal relationship. The MAP component is a first-order system with a threshold. Parameter identification was performed on data collected during positive step (drug on) and negative step (drug off) testing using multiple levels (2-6 mcg/kg/min) of infusion of dopamine in a canine model of acute ischemic heart failure. Parameter estimation utilized a least squares objective function and a linearized form of the step response of the model in the time domain. The model provides good approximations to the mean empirical responses.
Gingrich
K J
KJ
Department of Anesthesia, National Naval Medical Center, Bethesda, Md 20814.
Roy
R J
RJ
D000818:Animals; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008955:Models, Cardiovascular
D004298:Dopamine