The pressure and volume dependence of the rate of wash-out in the bovine eye.
The rate of increase of outflow facility (the wash-out rate) was measured in bovine eyes at 6 and 15 mm Hg. The time-rate-of-change of facility was less at 6 mm Hg (0.20: delta facility/hour) than at 15 mm Hg (0.44). However, when the data was analyzed as a function of volume passing through the outflow system, the volume-rate-of-change of facility was the same at 6 (0.35: delta facility/ml) and 15 mm Hg (0.34). This was consistent with the hypothesis of macromolecules "washing-out" of the aqueous outflow system, if these macromolecules were saturable in the perfusate.
Johnson
M
M
Massachusetts Institute of Technology, Cambridge.
Chen
A
A
Epstein
D L
DL
Kamm
R D
RD
D000818:Animals; D001082:Aqueous Humor / Q000502:physiology*; D002417:Cattle; D007429:Intraocular Pressure; D010477:Perfusion