Anti-ulcer effect in rats of bitter cardamon constituents.
The effects of bitter cardamon (the fruit of Alpinia oxphylla), used as a medicine and a condiment, on HCl/ethanol-induced gastric lesions in rats were examined. The acetone extract at 50 mg/kg, p.o. significantly inhibited gastric lesions by 57.0%. An analysis of the active constituents in the acetone extract was performed using column chromatography. Nootkatone at 20 mg/kg, p.o. significantly inhibited gastric lesion. These results suggest that nootkatone, the sesquiterpenoid is an important constituent in stomach medications containing bitter cardamon.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Li
Y H
YH
Tamai
Y
Y
D000818:Animals; D000897:Anti-Ulcer Agents; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats
D000897:Anti-Ulcer Agents; D010936:Plant Extracts