Translocation (16;21)(p11;q22) in acute monoblastic leukemia with erythrophagocytosis.
A patient with acute monoblastic leukemia with erythrophagocytosis and a t(16;21) (p11;q22), poor response to chemotherapy, early relapse, and a short survival of ten months is presented. Hematologically, this patient could be considered as a case of FAB M5b/t(8;16) but without the characteristic chromosomal translocation, i.e., there is no visible alteration on chromosome 8 and the breakpoint on chromosome 16 appears to be very proximal. These findings are briefly discussed in the light of other variants.
Marosi
C
C
First Department of Medicine, University of Vienna, Austria.
Bettelheim
P
P
Geissler
K
K
Lechner
K
K
Köller
U
U
Haas
O A
OA
Chott
A
A
Hagemeijer
A
A
D000328:Adult; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D004912:Erythrocytes; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000145:classification / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010587:Phagocytosis; D014178:Translocation, Genetic