[Fetal hemolytic disease in a patient immunized by six antibodies: diagnosis and treatment].
A case of severe haemolytic disease of the fetus due to six rare alloantibodies is described. In a pregnant women at 23 weeks gestation after the finding of a positive indirect Coombs test maternal antibodies have been precisely identified and titrated: anti-I: 1/23, anti-c: 1/64, anti-S: 1/16, anti-Fya: 1/128, anti-M: 1/64, anti-Jka: 1/32000. Fetal blood group, free and red blood cell adherent antibodies have been investigated on fetal blood samples obtained by means of cord centesis. A compatible donor has been found. Severe fetal anemia has been corrected by ultrasound guided intrauterine transfusions (one abdominal and two intravascular transfusions) with positive outcome of the pregnancy.
Tantalo
V
V
Istituti Clinici di Perfezionamento Centro Trasfusionale e di Immunoematologia, Università di Milano.
Rossi
E
E
Gianotti
G A
GA
Morotti
R
R
Zuliani
G
G
Buscaglia
M
M
Galligani
M
M
D000328:Adult; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
D007518:Isoantibodies
Malattia emolitica fetale in una paziente immunizzata da sei anticorpi: diagnosi e trattamento.