New analogues of rosaramicin isolated from a Micromonospora strain. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
Antibiotics 6108 A1, B, C and D, a new series of analogues of rosaramicin, were found together with rosaramicin, juvenimicin A4 and M-4365 A1 from the cultured broth of strain BA06108 which was assigned to be a new species of Micromonospora. 6108 A1 and C showed inhibitory activity against Gram-positive and some Gram-negative bacteria as potent as rosaramicin and exhibited low acute toxicity in mice. However, 6108 B showed less potent antimicrobial activity and 6108 D showed higher toxicity than those two antibiotics.
Funaishi
K
K
Okazaki Research Laboratory, Banyu Pharmaceutical Co., Ltd., Japan.
Kawamura
K
K
Satoh
F
F
Hiramatsu
M
M
Hagiwara
M
M
Okanish
M
M
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D050260:Carbohydrate Metabolism; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D007933:Leucomycins / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008847:Micromonospora / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D015394:Molecular Structure; D012988:Soil Microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy
D007933:Leucomycins; C066089:antibiotic 6108A1; C066090:antibiotic 6108B; C066091:antibiotic 6108C; C066088:antibiotic 6108D; C060286:rosaramicin