title: The effect of multivalent cations on adhesion time for cellular adhesion to solid surfaces.
abstract: The dynamic behavior of the adhesion of a charge-regulated cell to a solid surface of constant potential is investigated. In particular, the effect of the presence of multivalent cations in the suspension medium on adhesion time is discussed. By neglecting the effect of hydrodynamic retardation and assuming that the bulk liquid phase is stagnant, we show that the presence of multivalent cations has the effect of retarding cell adhesion. At a fixed level of ionic strength, the adhesion time increases with the increase of the concentration of multivalent cations in the suspension medium, and decreases with the increase in magnitude of the Hamaker constant. For a fixed concentration of cations, the adhesion time decreases with the increase of ionic strength. The effect of the magnitude of Hamaker constant on adhesion time is appreciable if both the ionic strength and the concentration of cations are high.
authors.affiliation: Department of Chemical Engineering, Tunghai University, Taichung, Taiwan, R.O.C.
authors.forename: Y I
authors.initials: YI
authors.lastname: Chang
authors.forename: J P
authors.initials: JP
authors.lastname: Hsu
mesh_terms: D000818:Animals; D002412:Cations / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D013997:Time Factors
chemical_list: D002412:Cations