title: Synthesis and antinociceptive activity of ring substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxypiperidines.
abstract: A series of phenyl substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxylpiperidine were synthesized and their antinociceptive activity tested in mice and compared with morphine sulphate. All compounds demonstrated antinociceptive activity in both the hot plate and the writhing tests. The studies showed that the antinociceptive activity is dependable on both the nature and the position of the substituent on the phenyl ring. Antagonism study with naloxone suggests possible interaction of the new compounds with the opioid receptors.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: K A
authors.initials: KA
authors.lastname: al-Rashood
authors.forename: A E
authors.initials: AE
authors.lastname: Madani
authors.forename: O T
authors.initials: OT
authors.lastname: Ginawi
authors.forename: S A
authors.initials: SA
authors.lastname: Ashraf
authors.forename: H A
authors.initials: HA
authors.lastname: el-Obeid
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D007540:Isonipecotic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D007540:Isonipecotic Acids; D009270:Naloxone