[Experimental study on cisplatinum ototoxicity].
Cisplatinum is a potent antineoplastic agent. Ototoxicity is one of the most prominent side effects. This paper reports characteristics of cisplatinum ototoxicity experiments showed that cisplatinum had ototoxic effects, both on hair cells and spiral ganglion neurons. The ototoxicity effect on hair cells and spiral ganglion neurons was demonstrated in the study. The inhibition of protein synthesis and metabolism may be responsible for its ototoxicity. The ototoxicity is progressive. Administration of large dose produces ototoxicity more easily.
Li
L
L
First Affiliated Hospital, Bethune University of Medical Sciences, Changchun.
D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold; D002945:Cisplatin / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D008297:Male
D002945:Cisplatin