title: [Severe poisoning with intravenous phenytoin in the newborn. Value of peritoneal dialysis].
abstract: A severe poisoning with intravenous phenytoin in a newborn was treated with peritoneal dialysis in spite of its reported poor effectiveness, the drug being 90% protein-bound. During 10 hours, 1.41 mg/hr were eliminated by biotransformation and 1.80 mg/hr were removed with peritoneal dialysis allowing to suppress quickly life threatening cardiac side effects. This efficacy may be explained by an increase in the unbound protein fraction and a diffusion speed through the peritoneum higher than in older patients.
authors.affiliation: Département de Pédiatrie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
authors.forename: P
authors.initials: P
authors.lastname: Narcy
authors.forename: G
authors.initials: G
authors.lastname: Zorza
authors.forename: A M
authors.initials: AM
authors.lastname: Taburet
authors.forename: J M
authors.initials: JM
authors.lastname: Mersch
authors.forename: D
authors.initials: D
authors.lastname: Devictor
authors.forename: G
authors.initials: G
authors.lastname: Huault
mesh_terms: D001711:Biotransformation; D001919:Bradycardia / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010530:Peritoneal Dialysis / Q000592:standards*; D010672:Phenytoin / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy*
chemical_list: D010672:Phenytoin
vernacular_title: Intoxication grave par la phénytoïne intraveineuse chez le nouveau-né. Intérêt de la dialyse péritonéale.