Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications.
This review describes the microencapsulation of pharmaceuticals using the technique of emulsification-solvent evaporation. Guidelines are given for development of encapsulation processes for drugs with either high or low aqueous solubilities. Methods for microsphere characterization and assessment are detailed. The properties of a range of encapsulating polymers are described with examples of drugs encapsulated. The article concludes by speculating the clinical potential of microsphere-based drug delivery systems.
Watts
P J
PJ
Department of Pharmaceutical Sciences, University of Nottingham, U.K.
Davies
M C
MC
Melia
C D
CD
D000818:Animals; D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D006801:Humans; D008863:Microspheres; D012997:Solvents
D002214:Capsules; D004337:Drug Carriers; D004655:Emulsions; D012997:Solvents