title: Phenoxybenzamine reduces mortality associated with intracerebral injections of excitatory neurotoxins.
abstract: Intracerebral injections of kainic acid produce gross hematuria, renal cortical necrosis, and an associated high mortality. Hematuria is virtually eliminated and mortality significantly reduced by pretreatment with phenoxybenzamine.
authors.affiliation: Department of Psychology, University of Western Ontario, London, Canada.
authors.forename: C H
authors.initials: CH
authors.lastname: Vanderwolf
authors.forename: R K
authors.initials: RK
authors.lastname: Cooley
mesh_terms: D000818:Animals; D004027:Diencephalon; D006417:Hematuria / Q000401:mortality / Q000517:prevention & control*; D007267:Injections; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D007672:Kidney Cortex / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D009498:Neurotoxins / Q000037:antagonists & inhibitors*; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D013687:Telencephalon
chemical_list: D009498:Neurotoxins; D010643:Phenoxybenzamine; D007608:Kainic Acid