Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors.
Significant positive effects could be achieved in a placebo-controlled double-blind study through the administration of 800 mg of garlic powder over a period of four weeks. Spontaneous thrombocyte aggregation disappeared, the microcirculation of the skin increased by 47.6% (from 0.63 +/- 0.13 to 0.93 +/- 0.22 mm/s), plasma viscosity decreased by 3.2% (from 1.25 +/- 0.34 to 1.21 +/- 0.43 mPas), diastolic blood pressure by 9.5% (from 74 +/- 9 to 67 +/- 5 mmHg), and blood glucose concentration by 11.6% (from 89.4 +/- 8.8 to 79.0 +/- 11.9 mg/dl). The vascular protection of garlic as atherosclerosis prevention by influencing the mentioned risk parameters for cardiovascular diseases must be pointed out. Especially interesting is the thrombocyte aggregation inhibiting effect. Thus, the application of garlic may be useful in case of acetylsalicyclic acid intolerance.
Kiesewetter
H
H
Department of Clinical Hemostasiology and Transfusion Medicine, University of the Saarland, Homburg.
Jung
F
F
Pindur
G
G
Jung
E M
EM
Mrowietz
C
C
Wenzel
E
E
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005737:Garlic; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D010979:Platelet Function Tests; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D010975:Platelet Aggregation Inhibitors; D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol