title: Deep brain stimulation in the treatment of chronic pain in man: where and why?
abstract: In current clinical practice, two brain structures are stimulated for the relief of chronic pain, namely the somatosensory thalamic nuclei (VPL-VPM) and the periventricular and periaqueductal gray matter (PVG-PAG). Whereas stimulation of the VPL-VPM is almost exclusively used for the treatment of deafferentation pain, stimulation of the PVG-PAG is mostly used in cases of nociceptive pain. We present our results of VPL-VPM stimulation in 36 patients with deafferentation pain. Initial pain relief was obtained in 61% of patients. To-day, after a mean follow-up of more than 4 years, 30% are still pain free. This success rate was found to be lower than the mean reported success rate of 57%, based on a survey of the world literature. Upon reviewing the literature, it was apparent that the reported success rates vary considerably between different authors. Some tentative explanations are given for this large discrepancy in success rate. The mechanisms by which electrical stimulation of the VPL-VPM suppresses deafferentation pain remain to be elucidated. Recent clinical and experimental findings suggest that a dopaminergic mechanism might be involved.
authors.affiliation: Department of Neurology and Neurosurgery, University of Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Gybels
authors.forename: R
authors.initials: R
authors.lastname: Kupers
mesh_terms: D001921:Brain / Q000502:physiology*; D002908:Chronic Disease; D004599:Electric Stimulation Therapy; D006801:Humans; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D013788:Thalamus / Q000502:physiology