Results of psychological testing of patients aged 3-6 years.
Cognitive development of early treated PKU children (132) was investigated by intelligence tests, tests for visual perception, motor and language development. Deviations from test norms occurred at 5 years of age concerning performance IQ, mathematical thinking, and visual perception. With the exception of mathematical thinking, "normal" results were obtained at the age of 6 years. Correlation with levels of plasma Phe revealed a relation between quality of dietary control and performance IQ. Results are discussed in light of methodological aspects and with respect to treatment consequence.
Michel
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U
Ruprecht-Karls-Universität Heidelberg, Kinderklinik, Federal Republic of Germany.
Schmidt
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E
Batzler
U
U
D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D003430:Cross-Sectional Studies; D006801:Humans; D007361:Intelligence Tests; D007804:Language Development; D008137:Longitudinal Studies; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000097:blood / Q000178:diet therapy / Q000523:psychology*; D011581:Psychological Tests
D010649:Phenylalanine