title: Intracerebroventricular infusions of insulin increase vasopressin release in rats.
abstract: 1. The role of cerebral insulin or insulin-like immunoreactive substance (ILI) on arginine-vasopressin (AVP) release using rats was investigated. Feeding rats with a high salt diet for 4 weeks significantly decreased the contents of ILI in both the hypothalamus and pituitary gland. Intracerebroventricular infusions of insulin (4 and 40 micrograms/min for 30 min) increased plasma AVP concentrations dose-dependently without hypoglycaemia, but decreased hypothalamic and pituitary contents of AVP. 2. These results indicate that ILI in the brain may play a role in the secretion of AVP, and that this mechanism could be operated to control a water-sodium balance.
authors.affiliation: Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Matsusawa
authors.forename: I
authors.initials: I
authors.lastname: Ikegaki
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Hirabayashi
authors.forename: M
authors.initials: M
authors.lastname: Yoshimura
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology; D002552:Cerebral Ventricles / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001685:Biological Factors; D007328:Insulin; D001127:Arginine Vasopressin