[Serum sialic acid bound to lipoproteins. Its contribution to the diagnosis and follow-up of melanoma].
Plasma lipid bound sialic acid (LSA) was measurement in 41 patients with malignant melanoma to determine the utility of this biochemical marker in the stating and in monitoring the post-operative follow-up. LSA was determined in 26 cases pre and post-operation, and in 15 cases only post-operation. Multiple determinations was done in 12 cases during two years of post-operative follow-up. Patients with preoperatory determination exhibited LSA levels significantly higher (p 0.0001) than the healthy control group. Relationship between LSA highest levels and tumoral size up 2 cm. in diameter was found (p 0.02). A second determination after 2 months of cases. LSA multiple post-operative controls showed continuing elevation of LSA levels up the normal rates was corresponding with metastasis in 100% of cases.
Sánchez Conejo-Mir
J
J
Departamento Dermatología Médico-Quirúrgica y Venerología, Facultad de Medicina de Sevilla.
Sotillo Gago
I
I
Camacho
F
F
Iglesias Huertas
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D011485:Protein Binding; D012794:Sialic Acids / Q000097:blood* / Q000378:metabolism; D012878:Skin Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000601:surgery
D014408:Biomarkers, Tumor; D008074:Lipoproteins; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid
Acido siálico sérico unido a lipoproteínas. Su aportación al diagnóstico y seguimiento en melanoma.