[Articular manifestations in Wegener's disease. Report of 13 cases].
Seventeen cases of Wegener's granulomatosis have been reviewed in search of articular involvement. Articular symptoms were present in 13 cases (76 p. cent), and were inaugural in 9 cases (53 p. cent). Six of these patients experienced arthralgias, which were most often migratory, and were inaugural in 3 cases. Seven patients had arthritides, which were inaugural in 6 cases; they were fixed and additive in 6 of these 7 cases, making up a distal polyarthritis in 3 patients, and an oligoarthritis in the 3 other ones; they were transient and migratory in 1 case. The 3 cases of distal polyarthritis were inaugural and fulfilled the ARA criteria for rheumatoid arthritis; two of them were accompanied by nodules which were quite identical to rheumatoid ones. There was no axial involvement. Joint involvement was not destructive and had a favourable course under disease treatment. Myalgias were present in 3 cases, one of which simulated Horton's disease. Biological manifestations chiefly consisted of marked inflammatory changes. Antineutrophil cytoplasm antibodies were present in 11 out of 16 patients in whom they were searched; among 6 of these patients who had active disease, they were present in 5. The antibody level decreased as treatment reduced disease activity and suppressed joint involvement. Joint involvement in Wegener's granulomatosis seems to be the inconstant hallmark of disease activity. It requires no specific treatment.
Alcalay
M
M
Service de Rhumatologie, CHRU La Miletrie, Poitiers.
Azais
I
I
Pallier
B
B
Touchard
G
G
Patte
F
F
Brugier
J C
JC
Debiais
F
F
Preud'homme
J L
JL
Ingrand
P
P
Babin
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis; D001168:Arthritis / Q000097:blood / Q000209:etiology* / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D007592:Joint Diseases / Q000097:blood / Q000209:etiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010146:Pain / Q000209:etiology; D012189:Retrospective Studies
D000906:Antibodies
Les manifestations articulaires de la maladie de Wegener. A propos de 13 observations.