[The effect of myosin from the human myocardium on quantitative T-lymphocyte values--active rosettes in patients with myocardial infarct and stenocardia].
The aim of the investigation is to study the influence of human myocardium myosin on the quantitative values of T-lymphocytes examined as active rosettes [correction of rosellae] in patients with ischemic heart disease. The study included 99 patients with ischemic heart disease, 49 of them with myocardial infarction and 50--with stenocardia. The controls were 61 clinically healthy donors. It was established that the active rosettes [correction of rosellae] in the patients with myocardial infarction were significantly less than in the controls (p less than 0.05). A significant inhibiting action of the human myocardium myosin on the active rosettes [correction of rosellae] was manifested (p less than 0.002). This action in the patients with stenocardia was less expressed (p less than 0.05). Myosin from a striated muscle did not exert an inhibiting action (p greater than 0.1). The results prove the participation of human myocardium myosin in the pathogenetic mechanism of T-lymphocytes suppression in patients with ischemic heart disease.
Manev
V
V
Penkova
K
K
Ivanov
G
G
Ivanova
I
I
Grigorov
M
M
Nedialkova
V
V
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000276:immunology*; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D003327:Coronary Disease / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology*; D009206:Myocardium / Q000276:immunology*; D009218:Myosins / Q000302:isolation & purification / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D009218:Myosins
Izsledvane na vliianieto na miozin ot choveshki miokard vŭrkhu kolichestvenite stoĭnosti na T-limfotsitite--aktivni rozetki pri bolni s infarkt na miokarda i stenokardiia.