Mercuric chloride inhibition of leucocyte migration.
The effects of mercuric chloride, at different concentrations, were tested on polymorphonuclear and mononuclear leucocyte migration by using the sealed capillary migration technique, and these effects were compared to influence on cell number and dye exclusion. A migration inhibition was obtained at 1.1 x 10(-5) M when tested on polymorphonuclear cells, while a concentration of 6.6 x 10(-5) inhibited the migration of mononuclear cells. Polymorphonuclear cells seemed to be more sensitive (were inhibited at a lower dose) to mercuric chloride as regards migration compared to cell number and dye exclusion, while mononuclear cells showed migration inhibition at about the same dose range as that which had effect on dye exclusion and cell number.
Nordlind
K
K
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Lidén
S
S
D002452:Cell Count; D002464:Cell Migration Inhibition; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology; D008627:Mercuric Chloride / Q000633:toxicity*; D008751:Methylene Blue; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology
D008627:Mercuric Chloride; D008751:Methylene Blue