Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity.
Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.
Sumoto
K
K
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Irie
M
M
Mibu
N
N
Miyano
S
S
Nakashima
Y
Y
Watanabe
K
K
Yamaguchi
T
T
D004249:DNA Damage; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology
D011719:Pyrazines; C017737:tagatosazine; C069873:deoxyfructosazine