[Six cases of Sjögren's syndrome with lichen mucosae--studies on the histopathology of salivary gland and clinical manifestation of sicca features in the patients with lichen mucosae].
A case of a 54-year old man with lichen mucosae and Sjögren's syndrome was reported. Clinical and histopathological analysis was made on the presence of sicca features in 6 patients with lichen mucosae. All patients complained either xerophthalmia or xerostomia and 5 out of 6 cases showed specific lymphocytic foci seen in Sjögren's syndrome in addition to lichenoid tissue reaction in the specimen obtained from buccal mucosae. Objective keratoconjunctivitis sicca was demonstrated in 3 cases. Immunologically, abnormal laboratory findings were observed in 5 cases (4 cases with a positive ANA and 3 cases with a positive anti microsome antibody). These findings suggest that lichen mucosae might develop in a close association with Sjögren's syndrome and relationship between these two disease was discussed in this article.
Tanei
R
R
Department of Dermatology, Kitasato University School of Medicine.
Katayama
I
I
Katou
I
I
Ota
Y
Y
Nishiyama
S
S
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000276:immunology / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology*
D000974:Antibodies, Antinuclear