Synthesis of azathia analogues of platelet activating factor with polyheterosidechains.
The synthesis of azathia analogues of the platelet activating factor with oxygen and sulphur-containing sidechains is reported. The starting point is 1-acetylthio-3-hydroxy-2-propaneamine-HCl, which permits the formation of the thioether and the acetamido linkage in one step. The phosphocholine part is introduced via 2-chloro-2-oxo-1,3,2-dioxaphospholane and subsequent ring opening with trimethylamine under pressure.
Zeidler
J M
JM
Pharmazeutisches Institut, Universität Tübingen, F.R.G.
Zimmermann
W
W
Roth
H J
HJ
D002845:Chromatography / Q000379:methods; D010742:Phospholipid Ethers / Q000737:chemistry*; D010743:Phospholipids / Q000138:chemical synthesis* / Q000302:isolation & purification; D010972:Platelet Activating Factor / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010742:Phospholipid Ethers; D010743:Phospholipids; D010972:Platelet Activating Factor