Additional predictive value of serum unsaturated vitamin B12 proteins in multiple myeloma.
The distribution of serum cobalamin-binding proteins was studied in 30 patients with low-grade multiple myeloma and in 26 patients with high-grade myeloma. The mean total cobalamin concentration (holotranscobalamin I and II) was similar in both groups of patients. We found a marked rise in total unsaturated binding cobalamin capacity mainly due to an increase in apotranscobalamin II (apo-TC II) in patients with high-grade myeloma. There was also a positive correlation between serum beta-2-microglobulin (B2M) and apo-TC II in myeloma patients. Our results indicate that pretreatment measurement of serum apo-TC II could supplement B2M as a prognostic guide.
Arnalich
F
F
Department of Medicine, La Paz Hospital, Facultad Autonoma de Medicina, Madrid, Spain.
Zamorano
A F
AF
Martinez-Hernández
P
P
Pena
J M
JM
Barbado
F J
FJ
Vázquez
J J
JJ
D000368:Aged; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D011379:Prognosis; D014155:Transcobalamins / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000032:analysis
D014155:Transcobalamins; D001613:beta 2-Microglobulin