title: Cellular role of DNA polymerase I.
abstract: Escherichia coli possesses three well-established DNA polymerases, I, II, and III. DNA polymerase I (Pol I) is the main repair polymerase in E. coli and also has a minor but important role in chromosomal replication. A major advantage of Pol I as an experimental system is its simplicity; unlike other replication enzymes, it is active as a single subunit. To a large extent, mutagenesis appears to be the result of (dis)functions of the DNA replication machinery. It is the purpose of this review to provide an integrated view of this relationship with particular emphasis on the role of Pol I in mutagenic events.
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Savic
authors.forename: M
authors.initials: M
authors.lastname: Jankovic
authors.forename: T
authors.initials: T
authors.lastname: Kostic
mesh_terms: D004256:DNA Polymerase I / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D016296:Mutagenesis / Q000502:physiology; D011995:Recombination, Genetic / Q000502:physiology; D013014:SOS Response, Genetics / Q000502:physiology
chemical_list: D004256:DNA Polymerase I