Effects of interleukin-1 alpha on migration of canine neutrophils in vitro and in vivo.
Inflammatory cell activation by interleukin-1 (IL-1) has been the subject of studies in laboratory animals and man, and was the aim of the present study. At physiological concentrations of 0.01-100 units/ml, human recombinant IL-1 alpha was shown to be a chemokinetic and chemotactic agent for canine neutrophils in vitro and to cause dose-dependent and selective neutrophil infiltration following intradermal injection of 1 or 250 units. The findings support a putative role for IL-1, and IL-1-induced products such as IL-8, as mediator of immunoinflammatory reactions in which neutrophil infiltration is prominent.
Thomsen
M K
MK
Department of Pharmacology, Leo Pharmaceutical Products, Ballerup, Denmark.
Thomsen
H K
HK
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004285:Dogs / Q000276:immunology*; D005260:Female; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000166:cytology*; D011994:Recombinant Proteins; D012867:Skin / Q000276:immunology
D007375:Interleukin-1; D011994:Recombinant Proteins