[Biosynthests of glutathione in yeasts].
From 3091 strains of yeast, a strain of Candida sp K11 was selected which can produce 18 mg glutathione (GSH) by one gram of the dried cells in the presence of L-CySH in the culture medium. The original strain K11 was subjected to mutagenesis by ultraviolet irradiation and a strain of analogue-antimetabolic mutant K11 UE 126 was selected on the plate of GSH metabolic analogue ethionine. The content of GSH in the K11 UE 126 cells increased by 49.7% over the original strain K11 even without adding L-CySH in the culture medium.
Zhan
G Y
GY
Shaanxi Institute of Microbiology, Xian.
Tian
P
P
Liu
W D
WD
Ye
M
M
D002175:Candida / Q000378:metabolism* / Q000528:radiation effects; D003545:Cysteine; D005978:Glutathione / Q000096:biosynthesis*; D009154:Mutation
D005978:Glutathione; D003545:Cysteine