Pulmonary surfactant secretion in the type II pneumocytes in inflamed condition.
Basal PC secretion in the type II pneumocytes from bronchitic rats was the same as that in the type II pneumocytes from normal rats. Neutrophils activated by opsonized zymosan or PMA, stimulated PC secretion in type II pneumocytes without causing any cell damage. The stimulation required close accession or attachment of neutrophils and type II pneumocytes and was not affected by the pretreatment with either SOD, catalase, AA861 or alpha 1-antitrypsin.
Oda
Y
Y
Department of Pharmacological Science, Faculty of Pharmaceutical Science, Kumamoto University, Japan.
Kai
H
H
Takaki
K
K
Yasunaga
T
T
Murahara
K
K
Kasano
M
M
Takahama
K
K
Miyata
T
T
D000818:Animals; D001991:Bronchitis / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D015054:Zymosan / Q000494:pharmacology
D011663:Pulmonary Surfactants; D015054:Zymosan