title: [The effect of calcium channel blockers on myoclonus induced by DDT].
abstract: Behaviour syndrome induced by P, p'-DDT in rats constitutes an experimental pattern of myoclonia whose neurochemical basis is not yet clear. In this paper, effects of some calcium canal antagonists (CCA) have been studied. Nicardipine, verapamil and diltiazem significantly reduce myoclonia intensity, whereas flunarizine and cinarizine (the two diphenylalkylamines) enhance it. Mechanisms involved are unknown and it is not possible to foresee the clinical usefulness of CCA in these changes.
authors.affiliation: Departamento de Investigación, Centro Ramón y Cajal, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: Rabasa
authors.forename: C
authors.initials: C
authors.lastname: Tabernero
authors.forename: B
authors.initials: B
authors.lastname: Pardo
authors.forename: J
authors.initials: J
authors.lastname: García de Yébenes
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003634:DDT; D004305:Dose-Response Relationship, Drug; D005260:Female; D009207:Myoclonus / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D003634:DDT
vernacular_title: Efecto de los antagonistas de los canales de calcio sobre las mioclonías inducidas por DDT.