title: Use of the 82Sr/82Rb generator in clinical PET studies.
abstract: The use of the 82Sr/82Rb generator in clinical positron emission tomography (PET) studies of myocardial perfusion has been described. An infusion pump is used to deliver the short-lived 82Rb from the generator to the patient. Various characteristics of the generator and the infusion system are described. The 82Rb yield was 69.8 +/- 13.3% and the 82Sr breakthrough was always less than the limit of 0.02 microCi/mCi 82Rb. The yield of 82Rb increased with the flow rate and the potency of the generator. Patients with coronary artery disease were studied for myocardial perfusion abnormalities by the 82Rb PET technique and images of excellent diagnostic quality were obtained.
authors.affiliation: Department of Nuclear Medicine, Cleveland Clinic Foundation, OH 44195-5074.
authors.forename: G B
authors.initials: GB
authors.lastname: Saha
authors.forename: R T
authors.initials: RT
authors.lastname: Go
authors.forename: W J
authors.initials: WJ
authors.lastname: MacIntyre
authors.forename: T H
authors.initials: TH
authors.lastname: Marwick
authors.forename: A
authors.initials: A
authors.lastname: Beachler
authors.forename: J L
authors.initials: JL
authors.lastname: King
authors.forename: D R
authors.initials: DR
authors.lastname: Neumann
mesh_terms: D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007260:Infusion Pumps; D011876:Radionuclide Generators; D012414:Rubidium Radioisotopes / Q000008:administration & dosage; D014055:Tomography, Emission-Computed
chemical_list: D012414:Rubidium Radioisotopes