title: [Multifactor analysis of the combined action of doxycycline and a peptidoglycan of microbial origin on the immune response].
abstract: Multifactorial analysis of the combined action of a microbial peptidoglycan and doxycycline on the immune response to antigens of the vaccine EV fraction 1 was made. Nomograms or equal level curves characterizing delayed hypersensitivity (DH) and antibody titers in various doses of the peptidoglycan and the antibiotic were plotted by the experimental data with a computer. The peptidoglycan had a pronounced immunomodulatory action on DH and antibody titers. However, the types of regulation of the both responses markedly differed. With multifactor analysis, the range of the values of the operating parameters, i.e. the drug doses and the time of their administration providing the required levels of DH and antibodies under the conditions of the combined therapy were defined.
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
authors.forename: L P
authors.initials: LP
authors.lastname: Ivanitskaia
authors.forename: L E
authors.initials: LE
authors.lastname: Bodunkova
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D004347:Drug Interactions; D005163:Factor Analysis, Statistical; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D010457:Peptidoglycan / Q000494:pharmacology*
chemical_list: D010457:Peptidoglycan; D004318:Doxycycline
vernacular_title: Mnogofaktornyĭ analiz kombinirovannogo deĭstviia doksitsiklina i peptidoglikana mikrobnogo proiskhizhdeniia na immunnyĭ otvet.