Tumor uptake of [48V]vanadyl-chlorine e6Na as a tumor-imaging agent in tumor-bearing mice.
[48V]Vanadyl-chlorine e6Na (48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were higher than those of 48V-labeled Pheo (48V-Pheo), and 48V-Chl showed a clear tumor image with low accumulation in liver, depending on the biodistribution of metal-free Chl having an affinity with tumor. 48V-Chl seems to be more suitable than 48V-Pheo as a tumor-imaging agent for photodynamic therapy of tumors.
Iwai
K
K
Laboratory of Nutrition, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Kimura
S
S
Ido
T
T
Iwata
R
R
D000818:Animals; D001345:Autoradiography; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D014638:Vanadates / Q000138:chemical synthesis / Q000493:pharmacokinetics*
D009942:Organometallic Compounds; C063041:vanadyl pheophorbide complex; C067998:vanadyl-chlorine e(6); D002734:Chlorophyll; D014638:Vanadates