title: Modulation of neuronal activity of locus coeruleus in rats induced by excitatory amino acids.
abstract: The excitatory actions on the unit activities of locus coeruleus induced by excitatory amino acids were studied. Quinolinic acid 10 nmol and N-methyl-D-aspartate (NMDA) 4 nmol icv markedly increased unit discharge of locus coeruleus neurons. The excitatory action was fully antagonized by icv 4 nmol D,L-2-amino-7-phosphonoheptanoic acid, a specific NMDA receptor antagonist. Excitatory effect induced by quinolinic acid is possibly mediated by excitatory amino acid receptors in locus coeruleus.
authors.affiliation: Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing.
authors.forename: H X
authors.initials: HX
authors.lastname: Ping
authors.forename: H Q
authors.initials: HQ
authors.lastname: Wu
authors.forename: G Q
authors.initials: GQ
authors.lastname: Liu
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004594:Electrophysiology; D005971:Glutamates / Q000494:pharmacology; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D009474:Neurons / Q000502:physiology; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D005971:Glutamates; D011805:Quinolinic Acids; C011829:glutamic acid diethyl ester; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid