[Reduction of antibiotic treatment of bacterial meningitis in children. Value of C-reactive protein monitoring].
The duration of antibiotic treatment of bacterial meningitis is always a topical issue. In our study (58 children), 21 of 24 meningococcal meningitis were treated for 4 or 5 days, 16 of 22 Haemophilus influenzae and 4 of 6 pneumococcal meningitis were treated for 7 days without increase in neurologic sequelae. A return of blood CRP levels to normal values was observed in all these patients simultaneously. Thus, CRP seems to be a good biological parameter for discussing treatment discontinuation. Furthermore, in some complications such as subdural effusion, a new increase of CRP levels was observed after the 5th day. A sequential follow-up of CRP levels at days J0, 5, 7, 10, seems a very useful tool for management of bacterial meningitis.
Astruc
J
J
Clinique des Maladies Infectieuses B, Centre Gui de Chauliac, Montpellier.
Taillebois
L
L
Rodière
M
M
Peskine
F
F
D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis*; D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000097:blood / Q000188:drug therapy*; D008585:Meningitis, Meningococcal / Q000097:blood / Q000188:drug therapy*; D008586:Meningitis, Pneumococcal / Q000097:blood / Q000188:drug therapy*
D002511:Cephalosporins; D002097:C-Reactive Protein
Raccourcissement du traitement antibiotique des méningites bactériennes de l'enfant. Intérêt de la surveillance de la C-réactive protéine.