[Anti-arrhythmic effects of matrine].
Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.
Zhang
B H
BH
Department of Pharmacology, College of Basic Medicine, Beijing Medical University, China.
Wang
N S
NS
Li
X J
XJ
Kong
X J
XJ
Cai
Y L
YL
D000157:Aconitine; D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001464:Barium; D017609:Barium Compounds; D002712:Chlorides; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011807:Quinolizines; D051381:Rats; D000093842:Matrines
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; D011807:Quinolizines; C024986:barium chloride; D001464:Barium; D000157:Aconitine; D000093842:Matrines