[Hierarchies in the structure and function of oxygen-binding proteins].
The structures of respiratory proteins such as hemoglobins and hemocyanins show obvious hierarchies. They belong to the class of allosteric macromolecules with cooperative functional properties, as do key metabolic enzymes. When examining the molecular mechanisms on which allostery and cooperativity are based, it could be shown for arthropod hemocyanins that the structural hierarchy of these macromolecules is reflected in a functional hierarchy. This relationship is described quantitatively in the "nesting" model. This model also offers explanations for the physiological significance of the prominent hierarchy of these molecules.
Decker
H
H
Zoologisches Institut der Universität, München, Bundesrepublik Deutschland.
Sterner
R
R
D000818:Animals; D006433:Hemocyanins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D046911:Macromolecular Substances; D008961:Models, Structural; D010100:Oxygen / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006454:Hemoglobins; D046911:Macromolecular Substances; D006433:Hemocyanins; D010100:Oxygen
Hierarchien in der Struktur und Funktion von sauerstoffbindenden Proteinen.