title: Evaluation of coagulation and fibrinolysis during the prodromal stages of carbohydrate-induced acute laminitis in horses.
abstract: The balance of coagulation and fibrinolysis was studied in 15 horses during the prodromal stages of acute laminitis induced by carbohydrate overload. Progression of the disease was stopped 12 to 24 hours before the expected onset of lameness in trial 1 (8 horses) and at the onset of lameness in trial 2 (7 horses). The end points in each trial were identified by specific changes in blood pressures (trial 1) and by changes in pulse, rectal temperature, and arterial pressure (trial 2) that were anticipated on the basis of original description of the experimental model. Blood samples for hemostasis evaluation were collected before and after carbohydrate overload in trial 1 and after carbohydrate overload in trial 2. Significant changes were not detected in platelet count, mean platelet volume, prothrombin time, activated partial thromboplastin time, fibrinogen concentration, plasminogen concentration, alpha-2-antiplasmin, antithrombin III, protein C, thromboxane B2, or fibrin(ogen) degradation product concentration. We concluded that an imbalance in coagulation and fibrinolysis is not pathogenic in the onset of experimentally induced equine acute laminitis. Because several test methods used to evaluate hemostasis in these horses were new, reference values for 34 healthy adult horses were established.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: K W
authors.initials: KW
authors.lastname: Prasse
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: J N
authors.initials: JN
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Duncan
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002241:Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects*; D002496:Central Venous Pressure / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects*; D005534:Foot Diseases / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D006439:Hemodynamics / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects; D006734:Horse Diseases / Q000097:blood / Q000209:etiology*; D006736:Horses; D007794:Lameness, Animal / Q000097:blood / Q000209:etiology; D013997:Time Factors
chemical_list: D002241:Carbohydrates