NPY-induced inhibition of male copulatory activity is a direct behavioural effect.
In adult, sexually-experienced male rats, the intracerebroventricular injection of NPY caused a dose-related inhibition of copulatory behaviour, all parameters (mount, intromission and ejaculation latencies, mount and intromission frequencies, mean inter-intromission interval, post-ejaculatory interval) being significantly worsened at the dose of 8 micrograms/rat. Since rats were deprived of food during the behavioural test, it is concluded that inhibition of sexual behaviour is a 'true', direct behavioural effect of NPY, not due to a shift towards increased feeding.
Poggioli
R
R
Institute of Pharmacology, University of Modena, Italy.
Vergoni
A V
AV
Marrama
D
D
Giuliani
D
D
Bertolini
A
A
D000818:Animals; D003307:Copulation / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y