[The role of testosterone metabolism in the hypothalamus in regulating the gonadotropic function of the hypophysis in male pre- and postpubertal rats].
Experiments were staged on immature (21 days) and mature (3.5 mos.) Wistar male rats to investigate the influence of the aromatase inhibitor 1, 4, 6-androstatriene-3, 17-dione on the activity of the aromatase and 5 alpha-reductase enzymatic complexes of the hypothalamus and the blood levels of LH and testosterone (T). The formation of 5 alpha-dehydrotestosterone against a background of aromatase activity inhibition was increased in mature rats and was unchanged in immature animals. The blood levels of LH and T were increased, the reaction of LH in immature animals being more marked. A conclusion has been made of a role of T aromatic transformations in the hypothalamus in tonic inhibition of LH secretion by endogenous T and a possible involvement of this mechanism in the maturation of male rats.
Reznikov
A G
AG
Sinitsyn
P V
PV
D000733:Androstatrienes / Q000494:pharmacology; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D047072:Aromatase Inhibitors; D042944:Cholestenone 5 alpha-Reductase; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood* / Q000187:drug effects; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology*; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000378:metabolism*
D000733:Androstatrienes; D047072:Aromatase Inhibitors; C011658:androsta-1,4,6-triene-3,17-dione; D013739:Testosterone; D007986:Luteinizing Hormone; D010088:Oxidoreductases; D001141:Aromatase; D042944:Cholestenone 5 alpha-Reductase
Rol' metabolizma testosterona v gipotalamuse v reguliatsii gonadotropnoĭ funktsii gipofiza u samtsov krys pre- i postpubertatnogo vozrasta.