[Comparative study of the toxicity of cyanic derivatives and/or aromatic amides].
The toxical potentiality of the cyanic radicle and the detoxicating characteristic of the amide group are studied following the evolution of the benzonitrile and benzamide toxicity when a cyanic or amide radicle is added to the original molecule. This comparative study shows that the presence of amide group has not always given a higher toxicity to the organic molecules that own it. It is the respective localization of the cyanic or amide radicles which appears to play the most important role.
Cheav
S L
SL
Laboratoire de Pharmacologie, UFR de Pharmacie, Tours.
Foussard-Blanpin
O
O
D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D051379:Mice; D009570:Nitriles / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001549:Benzamides; D009570:Nitriles; C014356:benzonitrile
Etude comparée de la toxicité de dérivés cyanés et/ou amides aromatiques.