title: Disease mechanisms in venous ulceration.
abstract: Disease mechanisms in venous ulceration are poorly understood. Recent hypotheses have postulated two separate mechanisms to explain the extensive microcirculatory damage which leads, eventually, to ulceration. A number of treatments, based on the suggested pathogenesis, have been undertaken and this review critically examines these theories in the light of the results of these treatments.
authors.affiliation: Department of Surgery, University College and Middlesex School of Medicine, Middlesex Hospital, London.
authors.forename: S
authors.initials: S
authors.lastname: Sarin
authors.forename: T R
authors.initials: TR
authors.lastname: Cheatle
authors.forename: P D
authors.initials: PD
authors.lastname: Smith
authors.forename: J H
authors.initials: JH
authors.lastname: Scurr
mesh_terms: D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D014652:Vascular Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D014655:Vascular Resistance