Effects of non-steroidal antiphlogistics on mouse ear oedema induced with dithranol.
Mouse ear oedema induced with dithranol in mice of the CFLP strain was decreased significantly, in a dose-dependent manner, by the oral administration of the following non-steroids 60 minutes before induction of the oedema: piroxicam, proquazone, azapropazone, nifluminic acid and phenylbutazone. An approximately 50% inhibitory effect could be attained with the following doses: 3.3 mg/kg piroxicam, 5 mg/kg proquazone, 5 mg/kg azapropazone, and 1 mg/kg nifluminic acid. Administration of the largest dose (30 mg/kg) of phenylbutazone, used for comparison, resulted in an oedema decrease of 41%.
Gábor
M
M
Institute of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Rázga
Z
Z
D000818:Animals; D000875:Anthralin; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000875:Anthralin