Intraarticular osmic acid in postinfectious arthritis persisting after treated bacterial arthritis.
We describe 4 patients successfully treated with intraarticular osmic acid for post-infectious arthritis persisting after apparent eradication of bacteria from the infected joint. In addition the bactericidal effect of osmic acid in vitro is demonstrated. We conclude that treatment with osmic acid carries no risk of iatrogenic infection; on the contrary, an antibacterial effect seems likely.
Järvinen
P
P
Rheumatism Foundation Hospital, Heinola, Finland.
von Essen
R
R
Nissilä
M
M
D000328:Adult; D001170:Arthritis, Infectious / Q000188:drug therapy*; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009993:Osmium Tetroxide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000302:isolation & purification
D009993:Osmium Tetroxide