[Virological evaluation of mumps meningitis following vaccination against mumps].
1) We report 5 cases of aseptic meningitis following vaccination against mumps. Of the 5 cases, 4 cases were diagnosed as mumps meningitis. 2 cases received monovalent mumps vaccine and the other 2 MMR vaccine. They consisted of 2 boys and 2 girls, aged 2 years and 2 months to 4 years and 5 months. The period between vaccination and symptoms ranged from 15 days to 20 days (mean 18 days). Cerebrospinal fluid of the cases contained 507 to 2688 cells/mm3. Eruption was observed in the 2 cases who received MMR vaccine, while parotid swelling was not seen in any case. 2) In all 4 cases, IgM antibody to mumps virus in the cerebrospinal fluid was detected by the ELISA or EIA methods. Causative organism of the fifth case was obscure. 3) PCR (Polymerase Chain Reaction) tests revealed that mumps virus isolated from 2 cases were of vaccine strain origin. 4) To evaluate the frequency of mumps meningitis following vaccination, it seems important to investigate carefully the number of children who received the vaccine and to exclude the cases of aseptic meningitis caused by other agents. On the other hand, cases of young infants tend to be overlooked because of atypical signs.
Mori
I
I
Department of Pediatrics, Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Torii
S
S
Hamamoto
Y
Y
Kanda
A
A
Tabata
Y
Y
Nagafuji
H
H
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008587:Meningitis, Viral / Q000209:etiology* / Q000382:microbiology; D009107:Mumps / Q000209:etiology* / Q000382:microbiology; D009108:Mumps Vaccine / Q000009:adverse effects*
D009108:Mumps Vaccine