[Severe poisoning with intravenous phenytoin in the newborn. Value of peritoneal dialysis].
A severe poisoning with intravenous phenytoin in a newborn was treated with peritoneal dialysis in spite of its reported poor effectiveness, the drug being 90% protein-bound. During 10 hours, 1.41 mg/hr were eliminated by biotransformation and 1.80 mg/hr were removed with peritoneal dialysis allowing to suppress quickly life threatening cardiac side effects. This efficacy may be explained by an increase in the unbound protein fraction and a diffusion speed through the peritoneum higher than in older patients.
Narcy
P
P
Département de Pédiatrie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
Zorza
G
G
Taburet
A M
AM
Mersch
J M
JM
Devictor
D
D
Huault
G
G
D001711:Biotransformation; D001919:Bradycardia / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010530:Peritoneal Dialysis / Q000592:standards*; D010672:Phenytoin / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy*
D010672:Phenytoin
Intoxication grave par la phénytoïne intraveineuse chez le nouveau-né. Intérêt de la dialyse péritonéale.