title: Morphological effects of the catechol estrogens on rat epididymal epithelia.
abstract: The 2-hydroxy and 4-hydroxyestradiols (2-/4-OHE2) caused marked cytotoxic effects, including vacuolation and nuclear changes, in rat epididymal epithelia, after exposure to very low levels (40 ng/rat/week) for 20 weeks. The effects of the 2-/4-OHE2 metabolites were more pronounced than that of estradiol-17 beta (E2).
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Pretoria, South Africa.
authors.forename: J C
authors.initials: JC
authors.lastname: Seegers
authors.forename: L B
authors.initials: LB
authors.lastname: Nieuwoudt
authors.forename: W S
authors.initials: WS
authors.lastname: Joubert
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects / Q000648:ultrastructure*; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002393:Estrogens, Catechol; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D002393:Estrogens, Catechol; D004958:Estradiol; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol