Prostaglandin F2 alpha stimulates gluconeogenesis in the perfused rat liver and this effect is blunted in livers from endotoxin infused rats.
Prostaglandin F2 alpha stimulates gluconeogenesis from lactate plus pyruvate in perfused rat livers. Continuous endotoxin infusion for 30 h in vivo prior to F2 alpha stimulation blunts this effect.
Spitzer
J A
JA
Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.
Deaciuc
I V
IV
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005943:Gluconeogenesis / Q000187:drug effects*; D007700:Kinetics; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D015237:Dinoprost