HLA-DR expression in macaque neuroendothelial cells in vitro and during SIV encephalitis.
HLA-DR expression in neuroendothelial cells (NEC) was studied during the course of SIV encephalitis in rhesus monkeys. HLA-DR determinants were detected on NEC in monkeys with SIV encephalitis, but not in control animals. In situ hybridization with an SIV probe indicated that HLA-DR expression was not a consequence of SIV replication within NEC. Cultured rhesus NEC stimulated with gamma interferon expressed HLA-DR to a higher degree than cultured brain fibroblasts or astrocytes. These data support the contention that NEC participate in retrovirus-induced inflammation and autoimmunity within the central nervous system.
Beilke
M A
MA
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Riding In
D
D
Hamilton
R
R
Stone
G A
GA
Jordan
E K
EK
Brashears
G
G
Nusbaum
W
W
Huddleston
D
D
Gibbs
C J
CJ
Gravell
M
M
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000382:microbiology / Q000473:pathology; D002478:Cells, Cultured; D004660:Encephalitis / Q000276:immunology / Q000382:microbiology*; D004730:Endothelium, Vascular / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000032:analysis*; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification; D013116:Spinal Cord / Q000382:microbiology / Q000473:pathology
D006684:HLA-DR Antigens