Treatment of severe pre-eclampsia by acetyl salicylic acid.
Low-dose Aspirin inhibits thromboxane A2 with minimal effects on prostacyclin and induces clinical improvements in pre-eclampsia. Two groups of pre-eclamptic women (10 in each) were treated either by low-dose acetyl salicylic acid (group I) or by conventional therapy (group II). Both groups showed a significant drop in systolic and diastolic blood pressure, a decrease in temperature, edema and albuminuria and an increase in urine volume. These effects were more significant in group I than in group II, except for the diastolic blood pressure. The obstetric progress and perinatal outcome were rather similar in both groups. These data offer a new potential therapeutic measure for the management of severe pre-eclampsia and call for further evaluation in a larger group of cases.
Toppozada
M
M
Department of Obstetrics and Gynaecology, Shatby Hospital, University of Alexandria, Egypt.
Khowessah
M
M
Shaala
S
S
Abd-Rabbo
S
S
Zoheir
A
A
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000188:drug therapy; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D001241:Aspirin