[Effect of human semen and vaginal bacteria culture fluid on induction of cervical cancer in mice].
The effect of human semen and culture fluid of bacteria (SB) isolated from the cervix of carcinoma patients on the induction of cervical carcinoma by 20-methylcholanthrene (MCA) in mice was studied. It was found that cervical carcinoma could be induced by SB with an induction rate of 12%. That by MCA alone was 11.8% whereas the SB positive for inducing EB virus EA in Raji cells used in combination with MCA gave an induction rate of 54.2%. The experimental results indicated that SB was both carcinogenic and tumor promoting. The possible mechanism of action of SB is discussed.
Sun
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Institute of Virology, Hubei Medical College, Wuhan.
D000818:Animals; D001407:Bacillus / Q000302:isolation & purification / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D002584:Cervix Uteri / Q000382:microbiology*; D003043:Cocarcinogenesis; D005260:Female; D006801:Humans; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D012661:Semen; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology
D008748:Methylcholanthrene