Comparison of the binding characteristics of serum albumins from various animal species.
In order to develop an animal model to study the bilirubin displacing effect of various drugs, we compared the bilirubin binding ability of human, pig, dog, rabbit, hamster, rat, guinea pig, and cat albumin. These albumins were used also to study the binding of monoacetyldiaminodiphenyl sulfone (MADDS). Using human, rat, guinea pig, and rabbit albumin, we studied the effect of sulfisoxazole, ceftriaxone, and tin protoporphyrin on bilirubin binding. Our results demonstrate that each animal albumin has different binding characteristics for the various chemicals tested. This variable must be considered before using an animal as a model for studying factors influencing bilirubin deposition in the brain.
Robertson
A
A
Department of Pediatrics, East Carolina University School of Medicine, Greenville, N.C.
Karp
W
W
Brodersen
R
R
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism*; D002443:Ceftriaxone / Q000378:metabolism; D006224:Cricetinae; D003622:Dapsone / Q000031:analogs & derivatives / Q000378:metabolism; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D008665:Metalloporphyrins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*; D013045:Species Specificity; D013444:Sulfisoxazole / Q000378:metabolism; D013552:Swine
D000890:Anti-Infective Agents; D008665:Metalloporphyrins; D012709:Serum Albumin; D013444:Sulfisoxazole; D002443:Ceftriaxone; D003622:Dapsone; C018965:monoacetyldapsone; D001663:Bilirubin