title: [Biotransformation of the anticholinesterase agent, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine].
abstract: Biotransformation of the anticholinesterasic agent 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine was studied in the laboratory rat. In the animal urine, the main identified metabolites were 9-amino-7-hydroxy-1,2,3,4-tetrahydroacridine and its conjugate with glucuronic acid, or sulfuric acid, as well as 9-amino-1-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine and 9-amino-2-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine. A part of the drug was excreted in an unchanged form.
authors.affiliation: Vojenská lékarská akademie J.E. Purkynĕ, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Patocka
authors.forename: J
authors.initials: J
authors.lastname: Bielavský
mesh_terms: D000818:Animals; D001711:Biotransformation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D013619:Tacrine; C016222:7-methoxytacrine
vernacular_title: Biotransformacní studie anticholinesterazika 9-amino-7-methoxy-1,2,3,4-tetrahydroakridinu.