Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs.
Butenafine is a new antifungal benzylamine. The efficacy of butenafine was investigated in an experimental tinea pedis model in guinea pigs, which is pathologically similar to natural infections in humans. Butenafine (0.1 ml) in 0.2 to 1.0% solutions was applied to the site of infection. Treatment was started on day 10 postinfection and was continued for 20 days. Butenafine applied once daily exhibited excellent dose-related therapeutic efficacy. The efficacy of butenafine was significantly superior to those tolnaftate, clotrimazole, and bifonazole.
Arika
T
T
Central Research Laboratories, Kaken Pharmaceutical Co., Ltd., Tokyo, Japan.
Yokoo
M
M
Maeda
T
T
Amemiya
K
K
Yamaguchi
H
H
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001596:Benzylamines / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D014008:Tinea Pedis / Q000188:drug therapy* / Q000382:microbiology; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D001596:Benzylamines; D009281:Naphthalenes; C067594:butenafine