[A multicenter study comparing nitrendipine and chlorthalidone in elderly hypertensive patients].
One hundred and eleven low-moderate hypertense elderly patients treated with nitrenpidine or chlortalidone were studied during 4 months either on monotherapy or in combination according to the therapeutic response observed. The therapeutic goal (diastolic arterial pressure less than 95 mmHg) was obtained in 92.4% of patients on nintrenpidine and in 49.1% on chlortidone, both on monotherapy (2 months) (p less than 0.001). At the end of the study 96.3% of patients reaches the therapeutic goal. Secondary effects were observed in 8.3% of patients on nitrenpidine and 6.1% on chlortalidone and in 11.1% of patients on combined treatment. No abnormalities were observed in blood biochemistry studied nor was there evidence of a significant influence of any of the two drugs on the patients quality of life which was evaluated through a specific questionnaire specially designed.
Guillén Llera
F
F
Servicio de Geriatría, Hospital de la Cruz Roja, Madrid.
Caballero
J C
JC
Guijarro
J L
JL
Reuss
J M
JM
Rodríguez Mañas
L
L
Sagués
F
F
Sempere
R
R
Tobares
N
N
Vigueras
S
S
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002752:Chlorthalidone / Q000627:therapeutic use*; D004361:Drug Tolerance; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009568:Nitrendipine / Q000627:therapeutic use*; D011788:Quality of Life; D013030:Spain; D011795:Surveys and Questionnaires
D009568:Nitrendipine; D002752:Chlorthalidone
Estudio multicéntrico comparativo entre nitrendipino y clortalidona en pacientes ancianos hipertensos.