[Early results of the studies of the effect of cimetidine on selected parameters of humoral and cellular immunity in patients with peptic ulcer].
The study aimed at evaluating an early effect of cimetidine on the blood IgG, IgA, IgM, number and functioning of T-cells in peripheral blood of patients with ulcerative disease. The study involved 27 patients (9 women and 8 men), aged between 27 and 70 years (mean 52.6 +/- 10.9 years). Nine of these patients suffered from the peptic ulcer and 8--from duodenal ulcer. Cell-mediated and humoral immunity were evaluated simultaneously in all patients prior to and after a 4-week treatment with cimetidine administered orally in the dose of 200 mg four times daily. Rosette test with theophylline and leukocyte migration test were used to assess cell-mediated immunity. It was found that cimetidine significantly increases blood serum IgG (p less than .01), the number of theophylline-resistant lymphocytes in TRFC-TR (P less than 0.01), and T-cell response to higher mitogen concentrations (PHA and Con-A) (p less than .005 and p less than .001, respectively).
Słotwiński
R
R
Katedry i Kliniki Chirurgii Gastroenterologicznej Instytutu Chirurgii, Warszawie.
Włodarska-Friszke
B
B
Muszyński
J
J
D000328:Adult; D000368:Aged; D002464:Cell Migration Inhibition; D002927:Cimetidine / Q000627:therapeutic use*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000187:drug effects*; D007958:Leukocyte Count; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D007136:Immunoglobulins; D002927:Cimetidine
Wczesne wyniki badań wpływu cymetydyny na wybrane parametry odporności humoralnej i komórkowej u chorych na chorobe wrzodowa.