EEG development in early treated PKU patients from birth to 6 years of age.
In 126 early treated PKU patients (type I and type II) a close EEG follow up was performed from birth up to 6 years of age. A total of 1465 EEGs were performed before and after onset of dietary treatment and on 11 more subsequent occasions. The composition of the background activity was normal up to 6 years when only a small number of the children (19) showed no dominant alpha activity. The frequency of epileptiform activity of generalised as well as focal type was low in the first 2 years of life, but afterwards slightly enhanced in comparison to normal control groups. Other findings like generalised theta paroxysms or focal slow waves were rarely observed. Under a standardised protein load at 6 months (52 patients) and at 5 years of age (42 patients) a moderate generalised slowing of the background activity but no other abnormalities were noted.
Pietz
J
J
Ruprecht-Karls Universität Heidelberg, Kinderklinik, Federal Republic of Germany.
Lütcke
A
A
Sontheimer
D
D
Benninger
C
C
Pietz
B
B
Batzler
U
U
Heusser
A
A
D000375:Aging / Q000502:physiology*; D004569:Electroencephalography; D006801:Humans; D007231:Infant, Newborn; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy / Q000503:physiopathology*
D010649:Phenylalanine