Acute central nervous system complications after pulse steroid therapy in patients with systemic lupus erythematosus.
We describe 2 patients with systemic lupus erythematosus (SLE) who developed an acute psychosis and a cerebrovascular accident after pulse methylprednisolone therapy. A literature review revealed 8 additional patients with SLE with acute central nervous system complications after pulse therapy.
Wysenbeek
A J
AJ
Department of Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Leibovici
L
L
Zoldan
J
J
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D051379:Mice; D011605:Psychoses, Substance-Induced / Q000209:etiology / Q000473:pathology
D000305:Adrenal Cortex Hormones; D008775:Methylprednisolone