title: Penicillin-binding protein 2 is essential for the integrity of growing cells of Escherichia coli ponB strains.
abstract: Analysis of Escherichia coli pbpA(Ts) or rodA(Ts) strains defective for penicillin-binding protein (PBP) 1A or PBP 1B indicated that the activity of PBP 2 is essential to prevent cell lysis in PBP 1B(-) strains and suggested that PBP 2 is active or activatable in rodA(Ts) mutants under restrictive conditions.
authors.affiliation: Centro de Biología Molecular, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: García del Portillo
authors.forename: M A
authors.initials: MA
authors.lastname: de Pedro
mesh_terms: D000560:Amdinocillin / Q000494:pharmacology; D001426:Bacterial Proteins; D002352:Carrier Proteins; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*; D006602:Hexosyltransferases / Q000235:genetics / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D002267:Muramoylpentapeptide Carboxypeptidase; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases / Q000235:genetics / Q000378:metabolism*; D013696:Temperature; D014161:Transduction, Genetic
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D000560:Amdinocillin