Antifungal combination therapy in localized candidosis.
A mouse model of localized candidosis in air-filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5-FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5-FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5-FC + Amph B was also tested against Candida albicans strains showing various degrees of 5-FC-resistance. A significant reduction in 5-FC-resistant mutants was seen after the treatment with the combination.
Polak
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Fa. Hoffmann-La Roche Ltd., Basel, Switzerland.
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D001393:Azoles / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000627:therapeutic use*; D051379:Mice
D001393:Azoles; D000666:Amphotericin B; D005437:Flucytosine