Respiratory function and liver cirrhosis.
Respiratory function was studied in 27 patients with liver cirrhosis and in a control group of 36 subjects. A significant difference in the overall comparison of the cirrhotic patients vs the control group was found only for average values of PEFR and FEF 25% (p less than 0.05); the significant reduction of PEFR was still present in ascitic subgroup. Considering other subgroups created vs control group, a restrictive alteration was observed in patients in Child's class C, with lower albumin levels and in presence of hyperbilirubinemia. An obstructive dysfunction was present in alcoholic cirrhotic patients. A significant decrease (p less than 0.05) of FEF 25-75% and FEF 75% (a specific small airways function index) was observed in patients with esophageal varices vs patients without varices, not related to ascites. The small airway functional alteration seems related to hemodynamic features of portal hypertension.
Caruso
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G
Cattedra di Terapia Media Sistematica, Università di Catania.
Catalano
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D
Corsaro
A
A
Salerno
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M
Sciuto
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L
Sciuto
V
V
Mazzone
O
O
D000368:Aged; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests