[CNS-active substances: synthesis of epoxybenzoxocines].
The 2-(2-Bromophenyl)-acetaldehyde acetals 8 are treated with n-BuLi and the aldehydes 7 and 11 to form the hydroxyacetales 9 and 12, respectively. 9 is cyclized under acidic conditions to the epoxybenzoxocine 2; analogously 12 yields the epoxydibenzoxocine 14.
Wünsch
B
B
Institut für Pharmazie und Lebensmittelchemie, Universität München.
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D001643:Bridged Bicyclo Compounds; D002491:Central Nervous System Agents; D004852:Epoxy Compounds
ZNS-Wirkstoffe: Synthese von Epoxybenzoxocinen.