title: Synthesis and absolute configurations of the cytotoxic polyacetylenes isolated from the callus of Panax ginseng.
abstract: Panaxacol (1) and dihydropanaxacol (2), cytotoxic polyacetylenes isolated from the callus of Panax ginseng, were synthesized starting from D-(-)-diethyl tartrate. The absolute configuration of 1 was determined to be 9R, 10R and the absolute configuration at C-3 of 2 was tentatively assigned as 3S by the application of the R(+)-alpha-methoxy-alpha-(trifluoro methyl)phenylacetyl (MTPA) method.
authors.affiliation: Nihon University, College of Pharmacy, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: N
authors.initials: N
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Kirisawa
mesh_terms: D000480:Alkynes / Q000032:analysis / Q000138:chemical synthesis*; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D053280:Diynes; D006018:Glycols / Q000032:analysis / Q000138:chemical synthesis*; D008968:Molecular Conformation; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal
chemical_list: D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D053280:Diynes; D006018:Glycols; C065780:panaxacol; C065781:dihydropanaxacol