[The effect of thymosin (fraction 5) and taktivin on adrenocortical function in mice].
A study was made of the effect of the thymic factors thymosin (fraction 5) and tactivin on adrenocortical function of BALB/C mature mice. A single administration of thymosin at a dose of 1 micrograms/mouse causes a rise of the blood level of corticosterone in 3 h. Dexamethasone, a blocker of ACTH secretion, stops the thymosin effect. Thymosin does not influence adrenocortical production of corticosterone in vitro. A marked tendency to a decrease in the blood level of corticosterone is clearly observed 3 h after tactivin administration at doses of 0.1, 0.5 and 2.5 micrograms/mouse. Tactivin added to the adrenal glands in vitro causes dose-dependent suppression of corticosterone specific production. A conclusion is that both factors act in opposite directions on adrenal functioning, and their influence on the glands is mediated differently.
Ignat'eva
E V
EV
Chesnokova
V M
VM
Ivanova
L N
LN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013949:Thymus Extracts / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C033782:thymosin fraction 5; D012710:Serum Albumin, Bovine; D013947:Thymosin; D003907:Dexamethasone; C036191:T-activin; D003345:Corticosterone
Vliianie timozina (fraktsiia 5) i taktivina na funktsiiu kory nadpochechnikov u mysheĭ.