Hemoglobin H disease complicated iron overload and HLA expression in Chinese.
HLA-A,B antigens were typed in 15 patients with Hemoglobin H disease; 10 of them had iron overloading. No significant HLA antigen specificity was identified to be at risk as compared with 170 controls. However, HLA-A11 was suggested to have significant negative risk, and may have a protective effect. (RR = 0.1, p = 0.0015). It seems that increased iron absorption in Hemoglobin H disease is not genetically associated with idiopathic hemochromatosis and certain HLA antigen expressions.
Chow
M P
MP
Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Hsu
H C
HC
Yung
C H
CH
Chau
W K
WK
Peng
H W
HW
Tsay
S H
SH
Tse
E
E
Lin
C K
CK
D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D015234:HLA-A Antigens / Q000378:metabolism; D015235:HLA-B Antigens / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012306:Risk; D013624:Taiwan; D013789:Thalassemia / Q000276:immunology / Q000378:metabolism*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D007501:Iron