[Effect of chronic enalapril treatment on prorenin, renin and sex hormones during the menstrual cycle in patients with essential hypertension].
Since angiotensin II seems to be involved in the process of ovulation we studied the effect of chronic enalapril on plasma prorenin, renin, estradiol, progesterone, LH and FSH during the menstrual cycle in ten essential hypertensive women. Our data show that peripheral blockade of A I conversion does not affect the pituitary guidance and the ovarian hormonal response of the menstrual cycle and, we can speculate, that it does not interfere with the process of ovulation.
Troffa
C
C
Centro Ipertensione, Clinica Medica, Università di Sassari.
Tonolo
G
G
Manunta
P
P
Pinna Parpaglia
P
P
Madeddu
P
P
Melis
M G
MG
Soro
A
A
Pala
F
F
Pazzola
A
A
Patteri
G
G
D000328:Adult; D000804:Angiotensin II / Q000502:physiology; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D004792:Enzyme Precursors / Q000097:blood*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008597:Menstrual Cycle / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects
D004792:Enzyme Precursors; D012739:Gonadal Steroid Hormones; D000804:Angiotensin II; D004656:Enalapril; D012083:Renin
Effetti del trattamento cronico con enalapril su prorenina, renina ed ormoni sessuali durante il ciclo mestruale in pazienti ipertese essenziali.