The ZFY gene family in humans and mice.
For several years, ZFY (zinc finger gene on the Y chromosome) was considered the best candidate for the human testis-determining gene TDF. This gene and its close relatives have been intensely studied in the hope of understanding the molecular biology of sex determination, particularly in humans and mice. Now that there is overwhelming evidence that ZFY and TDF are distinct loci, we are left with a large body of data, and a question: what do these genes really do?
Koopman
P
P
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, London, UK.
Ashworth
A
A
Lovell-Badge
R
R
D000818:Animals; D005075:Biological Evolution; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D051379:Mice; D005810:Multigene Family; D012732:Sex Determination Analysis; D013737:Testis / Q000378:metabolism; D014157:Transcription Factors; D014998:Y Chromosome; D016335:Zinc Fingers / Q000235:genetics*
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human