title: Distribution of acid phosphatase and beta-glucuronidase in the hypoplastic cerebellum of jaundiced Gunn rats. An enzyme histochemical study.
abstract: Activities of acid phosphatase and beta-glucuronidase in the cerebella of young jaundiced (j/j) and non-jaundiced (j/+; control) Gunn rats were studied with the enzyme histochemical method. The cerebellum of j/+ rats showed high acid phosphatase activities in Purkinje cells and neurons in the cerebellar nuclei. In j/j rats, a number of neurons were lost and numerous microglialike cells with a high acid phosphatase activity appeared in the hypoplastic cerebellum. Although beta-glucuronidase activity was rarely detected in the control cerebellum, a high enzyme activity was observed associated with microglialike cells in j/j rats. The present results provide a cytological basis for the reported differential increase in the activities of these lysosomal enzymes in the j/j rat cerebellum.
authors.affiliation: Department of Perinatology, Institute for Developmental Research, Aichi Prefecture Colony, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Keino
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Kashiwamata
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000002:abnormalities / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism*; D006651:Histocytochemistry / Q000379:methods; D007565:Jaundice / Q000201:enzymology*; D051381:Rats; D011911:Rats, Gunn
chemical_list: D000135:Acid Phosphatase; D005966:Glucuronidase