Is the proliferation inhibition of K562 cells by cisplatin also a membrane effect?
Using K562 tumour cells as model, the effect of cisplatin on cellular morphology and electrolyte balance was examined by scanning electron microscopy and energy-dispersive X-ray microanalysis. The data imply that the membrane surface alterations are a secondary effect following cross-linking reaction of this drug with DNA.
Peschke
T
T
GDR Academy of Sciences, Central Institute for Microbiology and Experimental Therapy, Jena.
Nagy
I
I
Szállási
Z
Z
Schröer
H P
HP
D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D002945:Cisplatin / Q000494:pharmacology*; D004577:Electron Probe Microanalysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D008855:Microscopy, Electron, Scanning
D002945:Cisplatin