Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways.
The effect of sensory neuropeptide depletion by systemic capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves), in guinea-pig trachea. Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors.
Stretton
C D
CD
Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
Belvisi
M G
MG
Barnes
P J
PJ
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009479:Neuropeptides / Q000172:deficiency*; D012677:Sensation / Q000502:physiology*; D014132:Trachea / Q000294:innervation*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D009479:Neuropeptides; D014660:Vasoactive Intestinal Peptide; D007545:Isoproterenol; D002211:Capsaicin