title: The value of preoperative radiotherapy response to maximizing laryngeal conservation in early stage supraglottic carcinoma.
abstract: This study is a retrospective review between 1976 and 1986 of 12 patients with T1(1) and T2(11) NO supraglottic cancers which were managed by a method that utilized planned preoperative radiotherapy (45-51 Gy) to the primary and bilateral necks. If adequate tumor response (greater than 75% reduction in size) was noted by laryngoscopy, therapy was completed at levels of 65-70 Gy to the primary. If a lesser tumor response was noted, the patient underwent supraglottic laryngectomy. Six patients completed primary radiotherapy (RT-RT) and six patients underwent supraglottic laryngectomy (RT-SG). There was evidence of residual tumor in three of six RT-SG patients. No tumor recurred at any site. Laryngeal function was preserved in all patients. Absolute survival was 58% at 67 months. This approach is oncologically sound and permits maximal laryngeal conservation.
authors.affiliation: Division of Otolaryngology Head and Neck Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
authors.forename: F G
authors.initials: FG
authors.lastname: Fedok
authors.forename: M
authors.initials: M
authors.lastname: Strauss
authors.forename: J
authors.initials: J
authors.lastname: Stryker
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies