[Problems posed by the development of exogenous surfactants for the treatment of hyaline membrane disease].
The hyaline membrane disease (HMD) is a respiratory distress occurring at birth of some premature infants, attributed to an endogenous pulmonary surfactant deficiency. The present treatments are iatrogenic and inefficient for the most diseased infants. The exogenous surfactant supplementation intends to give to the baby formulations playing in vivo the role of the natural surfactant. The research developed for the formulation and the diffusion of these exogenous surfactants have to solve physicochemical problems but also of industrial production and of safety use. In spite of their adequate physicochemical and pharmacological properties, surfactants of natural sources, for industrial grounds, are not still distributed at a large scale. The efficiency of artificial surfactants is variable, and the use of non-biodegradable molecules in several preparations let to safety problems. The development of new types of artificial surfactants, more efficient and safe, implies a better knowledge of the physico-chemical mechanisms intervening in the pulmonary surfactant dynamics.
Denizot
B A
BA
Laboratoire de Physicochimie des Surfaces, Faculté de Pharmacie, Châtenay-Malabry.
Tchoreloff
P C
PC
Bonanno
L M
LM
Proust
J E
JE
Lindenbaum
A
A
Dehan
M
M
Puisieux
F
F
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D006819:Hyaline Membrane Disease / Q000188:drug therapy*; D007231:Infant, Newborn; D011663:Pulmonary Surfactants / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry* / Q000627:therapeutic use
D011663:Pulmonary Surfactants; D013501:Surface-Active Agents
Les problèmes posés par la mise au point de surfactants exogènes pour le traitement de la maladie des membranes hyalines.