Ultra-rapid high-performance liquid chromatographic screening for phenothiazines in human samples.
A high-performance liquid chromatographic method is presented for the simultaneous identification and quantification of six commonly prescribed phenothiazines. Single-step extraction was achieved from alkaline samples with heptane - isoamyl alcohol (98.5 + 1.5), using prochlorperazine as an internal standard. A Spherisorb CN column was used, with a mobile phase of acetonitrile - acetate buffer (95 + 5). Detection was carried out at 254 nm.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Lamant
J M
JM
Mangin
P
P
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D010640:Phenothiazines / Q000097:blood*
D010640:Phenothiazines