[Features of incorporation of several antibiotics into erythrocyte ghosts--a system of targeted delivery of chemotherapeutic drugs].
Features of incorporation of cefazolin, ampicillin, kanamycin and gentamicin into erythrocytic shadows in patients with abdominal diseases and apparently healthy persons during hypoosmotic hemolysis were studied. The highest percentage of kanamycin and gentamicin incorporation into the erythrocytic shadows was observed. The parameter of the antibiotic incorporation from the incubation fluid into the erythrocytic shadows depended on the antibiotic type and dose. Rather significant resistance of the erythrocytic carriers with incorporated gentamicin to possible desorption and excretion of the antibiotic from the shadows into the blood flow was revealed which made their use possible for target release of antibiotics in the liver.
Zhumadilov
Zh Sh
ZhSh
Makarenkova
R V
RV
D000617:Aminoglycosides; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002437:Cefazolin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004910:Erythrocyte Membrane; D006461:Hemolysis; D006801:Humans; D008099:Liver / Q000378:metabolism; D009997:Osmotic Pressure; D010532:Peritoneal Diseases / Q000188:drug therapy
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D000667:Ampicillin; D002437:Cefazolin
Osobennosti vkliucheniia nekotorykh antibiotikov v éritrotsitarnye teni--sistemu tselenaproavlennoĭ dostavki khimioterapevticheskikh preparatov.