[Is there a hepatitis B virus (HBV) associated glomerulonephritis? Evaluation of the significance of HBV antigen deposition in the kidney].
In order to clarify the relationship between HBV infection and glomerulonephritis (GN) and to explore the significance and mechanism of HBV deposition in the kidney, renal biopsies from 60 patients with various forms of GN and HBV antigenemia (Agb) were compared with those from 59 age, sex and renal histology matched controls. The biopsies were studied with 4 layer PAP immunoperoxidase and immunofluorescence techniques using monoclonal antibodies to HBV surface (HBsAg), core (HBcAg) and e (HBeAg) antigens. All the 3 HBV antigens were detected in the kidneys of greater than 67% of the patients with membranous nephropathy and in greater than 64% of the cases with lupus nephritis regardless of the presence of HBV Agb or not. In certain patterns of primary GN, including mesangioproliferative GN, IgA nephropathy and membrano-proliferative GN. HBsAg in the kidney was more common in patients with HBs Agb than those without (47.7% vs 20.5%, P less than 0.05). No difference in HBcAg or HBeAg deposition was observed in patients with or without HBV Agb Granular deposition of HBV antigens was shown in the same pattern as that of Ig(s) and complement deposition. Renal HBV deposition correlated closely with the extent of other deposits. We concluded that the deposition of HBV antigens in kidney is often non-specific, although HBsAg is more commonly seen in some HBsAg carriers with primary GN Massive immune complex deposits seem to be the prerequisite of renal HBV deposition. The role of HBV in the development of GN is therefore not confirmed and further evaluation is needed for "HBV-TC nephritis".
Zhang
J H
JH
Department of Nephrology, Nanjing Army General Hospital.
Li
L S
LS
Zhou
H
H
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens