[Salivary testosterone levels in normal boys at puberty].
Salivary testosterone (Salivary-T) was measured in 133 normal boys at puberty (8-14 years old) and 21 adult males (24-36 years old) by using radioimmunoassay. Also, a simultaneous measurement was performed on salivary-T and serum total testosterone (Total-T) and free testosterone (Free-T) in order to study the correlation between saliva and serum. The results were summarized as follows: (1) Good correlations were observed in the values between Salivary-T and Total-T or Free-T. The correlation coefficient value was 0.54 between Salivary-T and Total-T, 0.84 between Salivary-T and Free-T when measured by DPC kit. Correlation coefficient value was 0.59 between Salivary-T by Wien kit and Total-T by DPC kit, also 0.77 between Salivary-T by Wien kit and Free-T by DPC kit. (2) Salivary-T, in the mean level, increased by age. The most rapid increase of Salivary-T was observed at 13 years of age. (3) Diurnal change of Salivary-T was observed at 13 years of age through adult age. Salivary-T level was highest in the morning and declined toward evening. (4) These results suggest that Salivary-T measurement was highly reliable and applicable for use in the monitoring of androgen status.
Umehara
T
T
Department of Urology, Sapporo Medical College.
Kumamoto
Y
Y
Mikuma
N
N
Itoh
N
N
Nanbu
A
A
Nitta
S
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D011627:Puberty / Q000378:metabolism*; D011863:Radioimmunoassay; D012463:Saliva / Q000737:chemistry*; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000032:analysis*
D013739:Testosterone