title: [Severe anaphylactoid reactions after intravenous corticosteroids. Report of a case and review of the literature].
abstract: We report a case of fatal anaphylactic reaction to intravenous methylprednisolone succinate therapy developed in a 51 year old asthmatic man with aspirin intolerance and undetermined myocarditis. 14 similar cases were found in literature and analysed: asthma and aspirin intolerance seem to be risk factors; the organism reacts against either unconjugated corticoid or esterified corticoid principally its succinate salt; the mechanism of these reactions remains not clear; it may be either a true allergic reaction or a non specific reaction.
authors.affiliation: Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers.
authors.forename: P
authors.initials: P
authors.lastname: Laine-Cessac
authors.forename: H
authors.initials: H
authors.lastname: Moshinaly
authors.forename: J P
authors.initials: JP
authors.lastname: Gouello
authors.forename: P
authors.initials: P
authors.lastname: Geslin
authors.forename: P
authors.initials: P
authors.lastname: Allain
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000150:complications; D004342:Drug Hypersensitivity / Q000150:complications; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate; D001241:Aspirin
vernacular_title: Réactions anaphylactoïdes graves après corticoïdes intraveineux. A propos d'un cas et revue de la littérature.