Transcranial magnetic stimulation excites the labyrinthine segment of the facial nerve: an intraoperative electrophysiological study in man.
The site where transcranial magnetic stimulation (magStim) depolarizes the facial nerve was investigated in 6 patients who underwent surgery of the cerebellopontine angle (CPA). The facial nerve was stimulated (1) magnetically prior to craniotomy, (2) electrically near the brainstem (elREZ), (3) at the exit from the CPA into the facial canal (elPorus), and (4) in the stylomastoid fossa (elStylo). The range of latency differences (delta) of compound muscle action potentials (CMAPs) recorded from the ipsilateral mentalis muscle were as follows: delta elREZ-magStim: +0.5 to +1.1 ms (P less than or equal to 0.03, Wilcoxon test); delta elPorus-magStim: +0.2 to +0.5 ms (P less than or equal to 0.03); delta elStylo-magStim: +0.8 to +1.0 ms (P less than or equal to 0.03). On the basis of anatomical data and a facial nerve conduction velocity of 33-46 m/s in these patients, it was concluded that transcranial magnetic stimuli depolarized the facial nerve at a location 10-15 mm distal to its entrance into the facial canal. This corresponds to the end of the labyrinthine segment of the facial nerve, i.e. the transit zone where the nerve ceases to be surrounded by cerebrospinal fluid (CSF) with its high electrical conductivity and enters the high-resistance tissue of the petrous bone.
Schmid
U D
UD
Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213.
Møller
A R
AR
Schmid
J
J
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology* / Q000601:surgery; D001933:Brain Stem / Q000502:physiology; D007758:Ear, Inner / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology; D005154:Facial Nerve / Q000502:physiology*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010812:Physical Stimulation; D013035:Spasm / Q000601:surgery; D050781:Transcranial Magnetic Stimulation