title: Phase II trial of Didemnin B in patients with advanced renal cell carcinoma.
abstract: Twenty-three patients with advanced renal cell cancer were treated with Didemnin B. One partial response was achieved (5%) in 21 evaluable patients. An allergic reaction was noted in four patients including one patient with anaphylaxis. Didemnin B is not recommended in the treatment of renal cell carcinoma.
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: R
authors.initials: R
authors.lastname: Motzer
authors.forename: H
authors.initials: H
authors.lastname: Scher
authors.forename: D
authors.initials: D
authors.lastname: Bajorin
authors.forename: C
authors.initials: C
authors.lastname: Sternberg
authors.forename: G J
authors.initials: GJ
authors.lastname: Bosl
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D047630:Depsipeptides; D004341:Drug Evaluation; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D015507:Drugs, Investigational; D010456:Peptides, Cyclic; C030051:didemnins