title: Effect of bromocriptine administration during mid-pregnancy on the ovary function in the pig.
abstract: Plasma concentrations of prolactin, luteinizing hormone (LH), progesterone, estradiol-17 beta and androgens testosterone with dihydrotestosterone were determined in pregnant gilts (n = 6) administered bromocriptine (BR) from 37-42 days of pregnancy. Blood samples were daily taken at 2h-intervals from day 34 to 45 of pregnancy. BR treatment reduced (p less than 0.001) prolactin secretion from 14.8 +/- 0.9 ng/ml to 8.6 +/- 1.1 and 5.5 +/- 0.7 during the initial 1-3 and 4-6 days of treatment, respectively. Following cessation of BR treatment prolactin returned to the pre-treatment concentrations (14.5 +/- 1.0). BR did not alter LH during the first 3 days of treatment but decreased LH on days 4-6 (1.5 +/- 0.1 vs 2.1 +/- 0.2, p less than 0.05). Bromocriptine evoked a 20% increase (p less than 0.05) in estradiol-17 beta during days 1-3 following onset of treatment, however it suppressed androgen concentrations from 10.7 +/- 1.2 to 5.6 +/- 0.4 pg/ml in the same period. Suppression of prolactin from day 37-42 with a concurrent decrease of LH from day 40-42 of gestation did not affect maintenance of pregnancy and surprisingly was associated with a temporary elevation of progesterone. We conclude that prolactin has no luteotrophic properties during midpregnancy in gilts.
authors.affiliation: Department of Animal Physiology, University of Agriculture and Technology, Olsztyn/Poland.
authors.forename: B
authors.initials: B
authors.lastname: Szafrańska
authors.forename: A J
authors.initials: AJ
authors.lastname: Ziecik
mesh_terms: D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013552:Swine / Q000502:physiology*; D013739:Testosterone / Q000097:blood
chemical_list: D013196:Dihydrotestosterone; D001971:Bromocriptine; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone