Post-treatment protection with piperonyl butoxide against acetaminophen hepatotoxicity is associated with changes in selective but not total covalent binding.
Brady
J T
JT
Toxicology Program: Department of Pharmacology, University of Connecticut, Storrs 06269.
Birge
R B
RB
Khairallah
E A
EA
Cohen
S D
SD
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010882:Piperonyl Butoxide / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D000082:Acetaminophen; D010882:Piperonyl Butoxide