Cardiac and circulatory response to the intravenous administration of urapidil during general anaesthesia.
The authors have assessed the hypotensive response to the intravenous administration of urapidil bolus, during intra-operative hypertensive crises, in 42 patients undergoing general anaesthesia for surgery. Twenty-two of these patients underwent major vascular surgery and were monitored through catheters introduced into the radial and pulmonary arteries, to study the haemodynamic changes induced by urapidil. A significant reduction was observed in these values: systolic and diastolic arterial pressure, systolic and diastolic pulmonary pressure, pulmonary wedge pressure and systemic vascular resistance. A non-significant reduction was observed in central venous pressure and pulmonary vascular resistance. Heart rate and cardiac output remained unchanged. Systolic arterial pressure decreased 12% from the baseline in 81% of patients. The transient action of urapidil bolus in some cases (55%) suggests the need for urapidil infusion.
Fontana
F
F
Service of Anaesthesia, Intensive Care and Antalgic Therapy, S. Corona Hospital, Garbagnate Milanese, Milan, Italy.
Allaria
B
B
Brunetti
B
B
Arienta
R
R
Favaro
M
M
Trivellato
A
A
Rusconi
M G
MG
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil