title: Activated human granulocytes contract isolated human airways.
abstract: Human granulocytes activated with serum treated zymosan (0.2 mg/ml) contract isolated human airways. The magnitude of the contraction depends on the number of granulocytes and the proportion of eosinophils among the granulocytes. The contraction is blocked by a leukotriene C4/D4 (LTC4/D4) receptor antagonist and by inhibition of lipoxygenase. This suggests that eosinophils rather than neutrophils are implicated in this response, which seems to be caused by LTC4/D4.
authors.affiliation: Department of Pediatrics, Erasmus University/Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: R C
authors.initials: RC
authors.lastname: Jongejan
authors.forename: J C
authors.initials: JC
authors.lastname: de Jongste
authors.forename: H C
authors.initials: HC
authors.lastname: Raatgeep
authors.forename: I L
authors.initials: IL
authors.lastname: Bonta
authors.forename: K F
authors.initials: KF
authors.lastname: Kerrebijn
mesh_terms: D001980:Bronchi / Q000502:physiology*; D016084:Bronchoconstriction / Q000502:physiology*; D002867:Chromones / Q000494:pharmacology; D004804:Eosinophils / Q000502:physiology; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D009637:Masoprocol / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors; D015054:Zymosan / Q000494:pharmacology
chemical_list: D002867:Chromones; D013189:SRS-A; D009637:Masoprocol; C006312:FPL 55712; D015054:Zymosan