Evidence of selective interaction between adenosine deaminase and acid phosphatase polymorphisms in fetuses carried by diabetic women.
Possible selective interaction between genetic polymorphisms of acid phosphatase locus 1 (ACP1) and adenosine deaminase (ADA) has been investigated in a sample of 211 infants from diabetic women, and in 350 consecutive infants from normal women. Newborns from diabetic pregnancies carrying the ADA2 allele show a lower proportion of BA and CB phenotypes (heterozygotes for the main allele of ACP1 system), compared with both their mothers and normal infants. The observation suggests that, in a diabetic environment, intrauterine selection may act against double heterozygotes for the ACP1 and ADA systems.
Bottini
E
E
Chair of Human Development, 2nd University of Rome, School of Medicine, Italy.
Gerlini
G
G
Lucarini
N
N
Amante
A
A
Gloria-Bottini
F
F
D000135:Acid Phosphatase / Q000096:biosynthesis*; D000243:Adenosine Deaminase / Q000096:biosynthesis*; D001724:Birth Weight; D003920:Diabetes Mellitus / Q000201:enzymology*; D005260:Female; D005333:Fetus / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011254:Pregnancy in Diabetics
D000135:Acid Phosphatase; D000243:Adenosine Deaminase