title: Respiratory deterioration during growth hormone therapy in a case of congenital nemaline myopathy.
abstract: Congenital nemaline myopathy (CNM) is generally classified as a non-progressive or slowly progressive neuromuscular disease. We describe a boy with CNM and an isolated partial growth hormone (GH) deficiency. From the onset of GH therapy his respiratory capacity deteriorated rapidly. The possible association between this deterioration and GH therapy is discussed.
authors.affiliation: Department of Paediatrics, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Logghe
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: F
authors.initials: F
authors.lastname: Jennekens
authors.forename: J E
authors.initials: JE
authors.lastname: Pruijs
mesh_terms: D000293:Adolescent; D013006:Growth Hormone / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D007040:Hypoventilation / Q000139:chemically induced* / Q000209:etiology; D008297:Male; D009132:Muscles / Q000187:drug effects; D009468:Neuromuscular Diseases / Q000150:complications / Q000151:congenital*; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000209:etiology; D012600:Scoliosis / Q000150:complications
chemical_list: D013006:Growth Hormone