Activated human granulocytes contract isolated human airways.
Human granulocytes activated with serum treated zymosan (0.2 mg/ml) contract isolated human airways. The magnitude of the contraction depends on the number of granulocytes and the proportion of eosinophils among the granulocytes. The contraction is blocked by a leukotriene C4/D4 (LTC4/D4) receptor antagonist and by inhibition of lipoxygenase. This suggests that eosinophils rather than neutrophils are implicated in this response, which seems to be caused by LTC4/D4.
Jongejan
R C
RC
Department of Pediatrics, Erasmus University/Sophia Children's Hospital, Rotterdam, The Netherlands.
de Jongste
J C
JC
Raatgeep
H C
HC
Bonta
I L
IL
Kerrebijn
K F
KF
D001980:Bronchi / Q000502:physiology*; D016084:Bronchoconstriction / Q000502:physiology*; D002867:Chromones / Q000494:pharmacology; D004804:Eosinophils / Q000502:physiology; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D009637:Masoprocol / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors; D015054:Zymosan / Q000494:pharmacology
D002867:Chromones; D013189:SRS-A; D009637:Masoprocol; C006312:FPL 55712; D015054:Zymosan