A new detector for fully automatic peptide synthesis.
A new method of monitoring the rate of reactions in solid-phase peptide synthesis is described. A conductivity detector in the reaction cell (patent applied for) enables the deprotection, washing and subsequent coupling stages to be examined in detail. The half-lives of the reactions can be calculated and hence the optimum reaction times can be predicted. Difficult sequences are sensed and appropriate action taken completely automatically.
Fox
J E
JE
School of Biochemistry, University of Birmingham, U.K.
D000595:Amino Acid Sequence; D001671:Biochemistry / Q000295:instrumentation*; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides