[Diphenylhydantoin induces an alteration in immune system cellular functions: an in vitro study of platelet and granulocyte aggregation].
In vitro experiments were performed in order to clarify the influence of phenytoin on human granulocyte and platelet function. Therapeutic anticonvulsant concentrations of the drug significantly reduced the granulocyte aggregation produced by formyl-methionyl-leucyl-phenilalanine; phytoemoaglutinin-induced granulocyte aggregation was unaffected by phenytoin. In the same range of concentrations the drug was able to inhibit ADP-, epinephrine- and collagen-induced platelet aggregation. The possible in vivo implications of these data are discussed.
Pasotti
D
D
Dipartimento di Medicina Interna e Terapia Medica, Sezione di Patologia Medica I, Università di Pavia.
Mazzone
A
A
Antoniello
N
N
Ricevuti
G
G
D002449:Cell Aggregation / Q000187:drug effects; D004347:Drug Interactions; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D010672:Phenytoin
La difenilidantoina induce alterazione delle funzioni delle cellule del sistema immunitario: studio in vitro dell'aggregazione delle piastrine e dei granulociti.