Acute promyelocytic leukemia in Crohn's disease. Case report and review of the literature.
A 19-year-old man with a documented 2-year history of Crohn's disease abruptly developed leukopenia and thrombocytopenia. A diagnosis of acute promyelocytic leukemia was established by bone marrow cytology. Chromosomal analysis of bone marrow aspirate revealed aberrations of no. 8 trisomy and translocation between no. 15 and no. 17 [46,XY,t(15q+,17q-)/47,XY,+8,t(15q+,17q-)]. Nine cases of Crohn's disease complicated by leukemia have been reported, including the present one; once again, a relationship between Crohn's disease and leukemia is suggested.
Orii
S
S
First Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
Sugai
T
T
Nakano
O
O
Yoshinari
H
H
Sato
S
S
D000328:Adult; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002898:Chromosomes, Human, Pair 8; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy