[Electrophysiological aspects of the effect of creatine phosphate on myocardial cellular activity in the normal state and in ischemia].
The electrophysiologic effects of phosphocreatine were assessed in isolated, superfused guinea pig ventricular tissues to gain an insight into its purported antiarrhythmic properties. Under normal conditions, 10 mM phosphocreatine significantly increased effective refractory period by 14.0 +/- 0.4%, but under ischemic-like conditions (hypoxia, hyperkalemia, acidosis) it showed no significant effect. Moreover, phosphocreatine reduced free [Ca2+]0 by nearly 20% and the changes induced by this compound in control tissues could be largely reproduced with an altered Tyrode's solution containing less than 0.6 mM Ca2+. The experiments suggest that phosphocreatine may act in a similar manner as class III antiarrhythmic agents on non-ischemic, normal tissue by mechanisms related in part to changes in extracellular Ca2+ composition.
Rozenshtraukh
L V
LV
Witt
R
R
Rozanski
G
G
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000889:Anti-Arrhythmia Agents; D003327:Coronary Disease / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009206:Myocardium / Q000166:cytology* / Q000473:pathology; D010725:Phosphocreatine / Q000494:pharmacology*; D011690:Purkinje Fibers / Q000166:cytology* / Q000473:pathology / Q000503:physiopathology; D016276:Ventricular Function
D000889:Anti-Arrhythmia Agents; D010725:Phosphocreatine
Elektrofiziologicheskie aspekty deĭstviia kreatinfosfata na kletochnuiu aktivnost' miokarda v normal'nykh usloviiakh i pri ishemii.