Influence of diazepam on the mitotic activity of adrenocortical cells in rats after unilateral adrenalectomy.
The effect of diazepam on adrenocortical cell proliferation was investigated in unilaterally adrenalectomized Wistar rats by evaluation of the mitotic ratio. Diazepam administration (5 mg/kg/day) was shown to decrease the mitotic index of the adrenal cortex on the 5th day after monoadrenalectomy, while on the 10th day after the operation the inhibitory effect became insignificant. The possible mechanism of diazepam action is discussed.
Zieleniewski
J
J
Clinic of Endocrinology, Academy of Medicine, Lódź, Poland.
Nowakowska-Jankiewicz
B
B
Stepień
H
H
Zieleniewski
W
W
D000302:Adrenal Cortex / Q000166:cytology*; D000315:Adrenalectomy; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003975:Diazepam