[Insulin-dependent complement activity in the serum of patients with diabetes mellitus].
Complement system was comparatively evaluated in 68 patients with diabetes mellitus and 104 healthy subjects. Hemolytic activity was examined for components C1, C2, C3, C4 and C5, and overall activity of the classic pathways was defined. The complement status appeared different for men and women. Females demonstrated hypofunction of the majority of the complement components, subcompensation in the absence of angiopathies, in decompensation complicated by angiopathies the activity was enhanced. In uneventful course of diabetes mellitus in males component C4 was activated remaining above normal though reduced in decompensation with angiopathies. High complement level in females could serve an aggravating factor, it depends on the dose of exogenic insulin.
Kozlov
L V
LV
Ageev
V P
VP
Sizoĭ
M N
MN
Mel'nik
E I
EI
Dedov
I I
II
Shamkhalova
M Sh
MSh
Abugova
I A
IA
D000293:Adolescent; D000328:Adult; D003167:Complement Activation / Q000187:drug effects*; D003165:Complement System Proteins / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D007328:Insulin; D003165:Complement System Proteins
Insulinz visimaia aktivnost' komplementa v syvorotke bol'nykh sakharnym diabetom.