title: Subfornical organ lesion decreases sodium appetite in the sodium-depleted rat.
abstract: The effect of subfornical organ (SFO) lesion on various models of ingestive behaviour was investigated in rats. Intake of water after 24 h water deprivation or systemic administration of hypertonic NaCl were not altered by SFO lesions. Intake of food or water after 24 h of food deprivation were not altered by SFO lesions. Intake of NaCl after furosemide-induced Na depletion was decreased by ablation of the SFO. This decrease in Na intake was ameliorated by pretreatment with a low dose of captopril. These results suggest that the SFO is involved in Na intake after Na depletion, but not in water or food intake following periods of water or food deprivation, respectively. The observation that a low dose of captopril can eliminate the decrease in Na appetite which occurred subsequent to SFO lesion suggests that other brain areas may also participate in Na-depletion-induced Na appetite.
authors.affiliation: Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Weisinger
authors.forename: D A
authors.initials: DA
authors.lastname: Denton
authors.forename: R
authors.initials: R
authors.lastname: Di Nicolantonio
authors.forename: D K
authors.initials: DK
authors.lastname: Hards
authors.forename: M J
authors.initials: MJ
authors.lastname: McKinley
authors.forename: B
authors.initials: B
authors.lastname: Oldfield
authors.forename: P G
authors.initials: PG
authors.lastname: Osborne
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology*; D002216:Captopril / Q000494:pharmacology; D003681:Dehydration / Q000503:physiopathology; D004326:Drinking / Q000502:physiology; D004435:Eating / Q000502:physiology; D006815:Hunger / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000172:deficiency*; D012982:Sodium, Dietary / Q000008:administration & dosage; D013356:Subfornical Organ / Q000502:physiology*
chemical_list: D012462:Saline Solution, Hypertonic; D012982:Sodium, Dietary; D002216:Captopril; D012964:Sodium