Hydrolysis and oxidation of 1H-benzotriazole-carboxylic acid esters by rat liver microsomes.
The 1H-benzotriazole-carboxylic acid esters under investigation were almost - with the exception of the tert.-butylester - completely hydrolyzed by rat liver microsomes. Some substrates were metabolically oxidized to a very small extent (less than 1%) yielding small amounts of possibly toxic metabolites after inhibition of the esterases with paraoxone.
Jacobi
S
S
Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main.
Hoffmann
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H
D000818:Animals; D002264:Carboxylic Acids / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet; D014230:Triazoles / Q000378:metabolism*
D002264:Carboxylic Acids; D014230:Triazoles