[Randomized study of the antiemetic efficacy of alizapride versus alizapride + dexamethasone].
We made a study on patients suffering from neoplasias treated with cisplatinum to compare antiemetic efficacy of alizapride or associated to dexamethasone. We divided patients in two groups. We somministred alizapride alone to the first group and alizapride plus dexamethasone to the second one. We evaluated presence or absence of emesis, its intensity and eventual tossic effects due to the drugs through an autocompilative questionnaire given to the patients. Our results didn't show important statistical differences between the two groups, though association with dexamethasone gets better emesis control. Alizapride anyway, didn't present important collateral effects, particularly extrapyramidal ones.
Epifani
C
C
Servizio di Oncologia Medica, Ospedale S. Anna, Como.
Scognamiglio
G
G
Prete
C
C
Alberio
F
F
Gini
G
G
Valli
M
M
D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011759:Pyrrolidines / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D011795:Surveys and Questionnaires; D014840:Vomiting, Anticipatory / Q000188:drug therapy*
D000932:Antiemetics; D011759:Pyrrolidines; D003907:Dexamethasone; C033968:alizapride
Studio randomizzato sull'efficacia antiemetica dell'alizapride versus alizapride + desametasone.