[Antiprolifirative effect of chlorbutin and sensitivity of patients with glomerulonephritis to this drug].
Children suffering from different forms of glomerulonephritis were examined for the sensitivity of peripheral blood lymphocytes to the antiproliferative action of chlorambucil in vitro. All the patients were given chlorambucil treatment in accordance with a 4-component scheme. As a result, in 15 patients (group I), a complete clinicolaboratory remission was attained. In 8 patients, (group II), the treatment results were estimated as a partial remission and in 8 patients (group III), the treatment turned out ineffective. In 14 patients of group I, the sensitivity of peripheral blood lymphocytes to the antiproliferative action of chlorambucil was viewed as high whereas in 7 patients of group III as low. Peripheral blood lymphocytes from group II patients had a low sensitivity to chlorambucil. The prognostic value of the laboratory test suggested is under discussion.
Pukhal'skiĭ
A L
AL
Toptygina
A P
AP
Dolomanova
O E
OE
Naumova
V I
VI
Torubarova
N A
NA
D000293:Adolescent; D000328:Adult; D000477:Alkylating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D002699:Chlorambucil / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male
D000477:Alkylating Agents; D007166:Immunosuppressive Agents; D002699:Chlorambucil
Antiproliferativnoe deĭstvie khlorbutina i chuvstvitel'nost' bol'nykh glomerulonefritom k terapii etim preparatom.