[The criterial significance of the histochemical manifestations of the nephrotoxic effect of mercury in its complex uptake into the body].
Certain aspects of kidney metabolism under a complex organism exposure to mercury have been studied. Different kinds of the heavy metal effect on various chains of metabolism have been established, dependent on the concentration and duration of mercury intake, which is evidence of the many mechanisms and ways of detoxication process. Oxido-reduction enzymes activity is changed due to direct mercury exposure, as well as due to disturbances in boundness of metabolic processes in which these enzymes are involved. The peculiarity of thiolysis mercury effect is the influence of mercury on protein metabolism enzymes--glutamate dehydrogenase (GDG) and NADF-dependent GDG, which is closely related to restructuring of oxidation-reduction kidney functions.
Ermachenko
A B
AB
Danilov
Iu V
IuV
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D002908:Chronic Disease; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008628:Mercury / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008630:Mercury Poisoning / Q000201:enzymology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D008628:Mercury
Kriterial'naia znachimost' gistokhimicheskikh proiavleniĭ nefrotoksicheskogo éffekta rtuti pri kompleksnom postuplenii ee v organizm.