title: Treatment of intermittent claudication: two different mechanisms.
abstract: (1) After surgical reconstruction in patients with isolated arterial occlusions, prolongation of walking distance depends on the increase in blood flow, i.e. the improvement of muscular working capacity is due to a "flow mechanism". (2) After medical therapy, the prolongation of walking distance does not depend on the response of total blood flow. This is most probably attributable to a shift of blood to muscle capillaries, i.e. the improvement of muscular working performance is due to a "distribution mechanism". (3) Combined therapeutic use of both mechanisms may ensure optimal results in the treatment of intermittent claudication.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Linhart
authors.forename: I
authors.initials: I
authors.lastname: Vanĕk
mesh_terms: D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply; D012039:Regional Blood Flow / Q000502:physiology; D016138:Walking