title: Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.
abstract: The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.
authors.affiliation: Department of Immunology, Hellenic Anticancer Institute, Athens, Greece.
authors.forename: C N
authors.initials: CN
authors.lastname: Baxevanis
authors.forename: S
authors.initials: S
authors.lastname: Frillingos
authors.forename: K
authors.initials: K
authors.lastname: Seferiadis
authors.forename: G J
authors.initials: GJ
authors.lastname: Reclos
authors.forename: P
authors.initials: P
authors.lastname: Arsenis
authors.forename: A
authors.initials: A
authors.lastname: Katsiyiannis
authors.forename: E
authors.initials: E
authors.lastname: Anastasopoulos
authors.forename: O
authors.initials: O
authors.lastname: Tsolas
authors.forename: M
authors.initials: M
authors.lastname: Papamichail
mesh_terms: D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D007519:Isoantigens / Q000008:administration & dosage; D010835:Phytohemagglutinins / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D007376:Interleukin-2; D007519:Isoantigens; D010835:Phytohemagglutinins; D011498:Protein Precursors; D015375:Receptors, Interleukin-2; C040782:prothymosin alpha; D013947:Thymosin