[Cardiac toxicity of 5-fluorouracil. Reflections on a case].
The authors relate a case of spasm occurring during cisplatin and 6-fluorouracil combination chemotherapy. The cardiotoxicity of 5-F.U., and namely the risk of coronary spasm, has been known since 1969. However, few cases have been reported in France. Referring themselves to the case of interest and to literature sources, the authors review current pathogenic hypotheses and specify the precautions commanded by the prescription of any protocol that includes 5-F.U.
Perreau
P
P
Service d'ORL, Hôpital Broussais, Paris.
Jaulmes
H
H
Bokowy
C
C
Demaldent
J E
JE
D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000209:etiology; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged
D005472:Fluorouracil
Toxicité cardiaque du 5-fluoro-uracile. Réflexions à propos d'un cas.