Massive hepatic enlargement with fatty change associated with ketoconazole.
Several forms of hepatic toxicity have been described with the antifungal agent ketoconazole. We report a case of massive liver enlargement with fatty infiltration presenting as gastric compression. This occurred in a young woman with AIDS taking ketoconazole as maintenance therapy for cryptococcal meningitis. This is the first reported case of ketoconazole causing fatty change in the liver.
Gradon
J D
JD
Division of Infectious Diseases, Maimonides Medical Center, Brooklyn, NY 11219.
Sepkowitz
D V
DV
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005234:Fatty Liver / Q000139:chemically induced* / Q000201:enzymology; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced* / Q000201:enzymology; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D007770:L-Lactate Dehydrogenase / Q000097:blood
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D007654:Ketoconazole