title: Metabolic profiles and lipoprotein lipid concentrations in non-obese and obese patients with polycystic ovarian disease.
abstract: Clinical parameters, androgen status and lipoprotein lipid profiles were assessed in 10 non-obese and 10 obese patients with polycystic ovarian disease (PCOD) and reference subjects matched for age, height and weight. Both obese and non-obese women with PCOD had significantly higher androgen levels when compared to the reference groups. When comparison of lipoprotein lipid profiles were made between groups, non-obese women with PCOD had significantly higher total cholesterol, triglycerides and LDL-cholesterol levels than non-obese reference subjects. Obese PCOD women manifested significantly higher total cholesterol, LDL-cholesterol, cholesterol/HDL, and LDL/HDL values than did obese reference subjects. Correlations between serum androgens and lipoprotein lipid concentrations in PCOD and normal women were unhelpful. Both non-obese and obese patients with PCOD had significantly higher systolic and diastolic blood pressures (BPs) than the reference groups. Thus, both non-obese and obese women with PCOD manifest hyperandrogenaemia which may result in a male pattern of lipoprotein lipid concentrations.
authors.affiliation: Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Mahabeer
authors.forename: C
authors.initials: C
authors.lastname: Naidoo
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
authors.forename: I
authors.initials: I
authors.lastname: Jialal
authors.forename: K
authors.initials: K
authors.lastname: Reddi
authors.forename: S M
authors.initials: SM
authors.lastname: Joubert
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D000728:Androgens; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol