title: Cefodizime, a new 2-aminothiazolyl cephalosporin: physicochemical properties, toxicology and structure-activity relationships.
abstract: Cefodizime is a 2-aminothiazolyl cephalosporin for parenteral use. Cefodizime has a bisubstituted thiothiazole moiety in position 3 of the cephem nucleus. The presence of this moiety does not alter the in-vitro antibacterial activity, or safety in animal studies, which are similar to those of cefotaxime, but results in an apparent long elimination half-life in rodents and dogs, and in novel immunological properties.
authors.affiliation: Centre de recherche Roussel-Uclaf, Romainville, France.
authors.forename: A
authors.initials: A
authors.lastname: Bryskier
authors.forename: T
authors.initials: T
authors.lastname: Procyk
authors.forename: M T
authors.initials: MT
authors.lastname: Labro
mesh_terms: D000818:Animals; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D002439:Cefotaxime; C033356:cefodizime