[Interferences between nutrients in their absorption from the peritoneal cavity in rats].
With the aim of detecting possible interferences in the absorption of glucose, amino acids and fats we infused several combination of them into the peritoneal cavity of the Wistar rats. After intraperitoneal infusion of 2 mu Ci-L-glucose-C14 with 5 ml of D-glucose 5 per 100 and L-glucose-C14 with 5 ml of "16N" 3.5 per 100 in different groups of animals, we detected slight differences in plasma radioactivity one hour after infusion. We also found moderated differences in plasma radioactivity among the groups of animals infused with 1 mu Ci of fat radioactive amino acids plus 5 ml of D-glucose 5 per 100 and in the group infused with 1 mu Ci of 5-L-amino acid-C14 plus 5 ml of "16N" 3.5 per 100, after four hours of the infusion. We found no differences among those groups of animals infused with fat plus glucose and with fat plus amino acid with respect to those infused with fat alone. In summary, as glucose and amino acid absorption pathway are the same (capillary flow) seem reasonable that they interfere with each other when they are infused intraperitoneally. Fat infusion that not seem to interfere with other substrates possible due to the different absorption pathway (lymphatic channels) but further studies are needed to determine this.
Morán Penco
J M
JM
Departamento de Cirugía, UNEX, Facultad de Medicina, Universidad de Extremadura, Badajoz.
Mahedero Ruiz
G
G
Maciá Botejara
E A
EA
Salas Martínez
J
J
Blanco Alonso
M
M
D000042:Absorption; D000596:Amino Acids / Q000008:administration & dosage; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002250:Carbon Radioisotopes; D004347:Drug Interactions; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D007263:Infusions, Parenteral; D010529:Peritoneal Cavity / Q000502:physiology*; D051381:Rats
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005217:Fat Emulsions, Intravenous; D005947:Glucose
Interferencias entre nutrientes en su absorción desde la cavidad peritoneal de ratas.