[Discordance between clinical and immunological aspects in a case of chronic B-type lymphoproliferative syndrome].
Chronic lymphoproliferative disorders are extremely heterogeneous from a clinical, morphological and immunological point of view. The paper reports the case of a woman with chronic prolymphocytic leukemia. The neoplastic clone revealed the typical immunological features of pre-B lymphocytes, which are at an earlier stage of differentiation in respect to prolymphocytes. After polychemotherapy (CEOP) the phenotype of the neoplastic cells shifted to an immunological pattern typical of B lymphocytes.
Bisail
M
M
Università degli Studi di Sassari, Istituto di Clinica Medica, Ospedale Civile, Sassari.
Cassisa
L
L
Manca
M
M
Casula
S
S
Fele
G
G
Malavasi
A
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use; D015251:Epirubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D010641:Phenotype; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013237:Stereoisomerism; D014750:Vincristine / Q000627:therapeutic use
D015251:Epirubicin; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone
Discordanza tra aspetti clinici ed immunologici in un caso di sindrome linfoproliferativa cronica di tipo B.