title: Contrast manipulation and artifact assessment of 2D and 3D RARE sequences.
abstract: The extent of contrast manipulation and the assessment of characteristic artifacts in imaging studies of brain and knee as performed with novel variants of the Rapid Acquisition Relaxation Enhanced (RARE) sequence are reported. Methods of ordering the phase encoding within one or two echo trains are proposed for manipulating T2 contrast. Options for minimizing artifacts associated with the various schemes are discussed. The extent of T1 contrast manipulation in RARE sequences is explored by varying repetition rates in a signal averaging scheme and by applying inversion pulses prior to data acquisition. The results demonstrate that RARE sequences can be utilized for obtaining good quality images with a range of tissue contrast options similar to those associated with slower spin-echo methods. They also suggest that RARE applications need not be confined to highlighting long T2 fluid spaces, an application already well documented.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: S T
authors.initials: ST
authors.lastname: Wong
authors.forename: C
authors.initials: C
authors.lastname: Winalski
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000033:anatomy & histology; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007719:Knee Joint / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008433:Mathematics; D008962:Models, Theoretical; D009103:Multiple Sclerosis / Q000473:pathology; D009132:Muscles / Q000033:anatomy & histology; D012815:Signal Processing, Computer-Assisted