[Microassay of plasma and erythrocyte metformin by high performance liquid chromatography].
The proposed HPLC method allows the quantification of plasma and intra-erythrocyte metformin after simple acid deproteinisation of blood samples and injection on a cation exchange column. Its speed and sensitivity are perfectly adapted to the needs of an invasive monitoring of diabetic patients treated with this hypoglycaemic.
Lacroix
C
C
Glucophage, Laboratoires Aron-Médicia, Lyon, France.
Danger
P
P
Wojciechowski
F
F
D000140:Acidosis, Lactic / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003920:Diabetes Mellitus / Q000188:drug therapy; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D008687:Metformin / Q000097:blood* / Q000627:therapeutic use; D008832:Microchemistry
D008687:Metformin
Microdosage de la metformine plasmatique et intraérythrocytaire par chromatographie en phase liquide.