Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus.
In 87 randomly selected diabetic patients (67 type 1, 20 type 2) and 25 control subjects, gastric emptying of digestible solid and liquid meals and oesophageal transit of a solid bolus were measured with scintigraphic techniques. Gastrointestinal symptoms, autonomic nerve function and glycaemic control were evaluated in the diabetic patients. Gastric emptying and oesophageal transit were slower (P less than 0.001) in the diabetic patients compared with the control subjects, and each was delayed in about 40% of them. There was a relatively weak (r = 0.32; P less than 0.01) relationship between solid and liquid gastric emptying, and no significant correlation (r = 0.11, NS) between oesophageal transit and gastric emptying of the solid meal. Scores for upper gastrointestinal symptoms and autonomic nerve function correlated weakly (r = 0.21; P less than 0.05) with both oesophageal transit and gastric emptying. Gastric emptying of the liquid meal was slower (P less than 0.05) in patients with blood glucose concentrations greater than 15 mmol/l. These results indicate that gastric emptying in patients with diabetes mellitus should be assessed by liquid as well as by solid test meals and that oesophageal transit should not be used as a predictor of generalised diabetic gastroenteropathy.
Horowitz
M
M
Department of Medicine, Royal Adelaide Hospital, South Australia, Australia.
Maddox
A F
AF
Wishart
J M
JM
Harding
P E
PE
Chatterton
B E
BE
Shearman
D J
DJ
D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
D007205:Indium Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid; D004369:Pentetic Acid