title: Molecular and cellular aspects of early B-cell development.
abstract: The molecular mechanisms underlying pre-B cell growth and immunoglobulin gene rearrangement have been actively investigated. Some growth factors for B-cell precursors as well as some genes activating V(D)J recombination have been identified. Furthermore, the molecular structure and signaling capacity of the surface immunoglobulin of pre-B cells have been characterized.
authors.affiliation: Max-Planck Institute for Immunobiology, Freiburg, FRG.
authors.forename: T
authors.initials: T
authors.lastname: Tsubata
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002455:Cell Division; D016207:Cytokines / Q000235:genetics; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics; D005803:Genes, Immunoglobulin; D007136:Immunoglobulins / Q000235:genetics; D013234:Stem Cells / Q000166:cytology
chemical_list: D016207:Cytokines; D007136:Immunoglobulins