title: An experimental randomized study of six different ventilatory modes in a piglet model with normal lungs.
abstract: A randomized study of 6 ventilatory modes was made in 7 piglets with normal lungs. Using a Servo HFV 970 (prototype system) and a Servo ventilator 900 C the ventilatory modes examined were as follows: SV-20V, i.e. volume-controlled intermittent positive-pressure ventilation (IPPV); SV-20VIosc, i.e. volume-controlled ventilation (IPPV) with superimposed inspiratory oscillations; and SV-20VEf, i.e. volume-controlled ventilation (IPPV) with expiratory flush of fresh gas; HFV-60 denotes low-compressive high-frequency positive-pressure ventilation (HFPPV) and HVF-20 denotes low-compressive volume-controlled intermittent positive-pressure ventilation; and SV-20P denotes pressure-controlled intermittent positive-pressure ventilation. With all modes of ventilation a PEEP of 7.5 cm H2O was used. In the abbreviations used, the number denotes the ventilatory frequency in breaths per minute (bpm). HFV indicates that all gas was delivered via the HFV 970 unit. The ventilatory modes described above were applied randomly for at least 30 min, aiming for a normoventilatory steady state. The HFV-60 and the HFV-20 modes gave lower peak airway pressures, 12-13 cm H2O compared to approximately 17 cm H2O for the other ventilatory modes. Also the mean airway pressures were lower with the HFV modes 8-9 cm H2O compared to 11-14 cm H2O for the other modes. The gas distribution was evaluated by N2 wash-out and a modified lung clearance index. All modes showed N2 wash-out according to a two-compartment model. The SV-20P mode had the fastest wash-out, but the HFV-60 and HFV-20 ventilatory modes also showed a faster N2 wash-out than the others.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anestesiology and Intensive Care, University Hospital, Uppsala, Sweden.
authors.forename: J B
authors.initials: JB
authors.lastname: Nielsen
authors.forename: U H
authors.initials: UH
authors.lastname: Sjöstrand
authors.forename: S W
authors.initials: SW
authors.lastname: Henneberg
mesh_terms: D000403:Airway Resistance; D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D015633:Extravascular Lung Water / Q000737:chemistry; D006439:Hemodynamics; D006611:High-Frequency Jet Ventilation / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D008176:Lung Volume Measurements; D008991:Monitoring, Physiologic; D011175:Positive-Pressure Respiration; D013552:Swine