Genetic heterogeneity of the human glutathione transferases: a complex of gene families.
The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationships between the various isoenzymes, their deficiencies and the physical locations of their genes.
Board
P
P
Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra ACT.
Coggan
M
M
Johnston
P
P
Ross
V
V
Suzuki
T
T
Webb
G
G
D000818:Animals; D005796:Genes; D005982:Glutathione Transferase / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D006824:Hybridization, Genetic; D007527:Isoenzymes / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008099:Liver / Q000201:enzymology; D010641:Phenotype
D007527:Isoenzymes; D005982:Glutathione Transferase