Activation of 1-hydroxymethylpyrene to an electrophilic and mutagenic metabolite by rat hepatic sulfotransferase activity.
Surh
Y J
YJ
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706.
Blomquist
J C
JC
Miller
J A
JA
D000818:Animals; D001711:Biotransformation; D002712:Chlorides / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009153:Mutagens / Q000378:metabolism; D011721:Pyrenes / Q000378:metabolism* / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced; D013466:Sulfurtransferases / Q000378:metabolism*
D002712:Chlorides; D009153:Mutagens; D011721:Pyrenes; D004247:DNA; C065833:1-hydroxymethylpyrene; D013466:Sulfurtransferases