title: [Preventive systemic cyclosporin A in risk keratoplasty].
abstract: Systemic cyclosporin A prophylaxis was applied in 18 high-risk corneal transplants. Immunoreactions occurred in three cases. They correlated with too low serum level of cyclosporin A. Two of them could be reversed by an increase of cyclosporin A dosage in combination with an intensive corticosteroid therapy. Four corneal transplants failed from persistent severe basic disease. Eleven corneal transplants remained clear during the follow-up (5-33 months). A constant trough cyclosporin A serum level of 100-120 ng/ml has been shown to exert efficient immunomodulating effects. We currently judge a postoperative prophylaxis period of 6 to 12 months with cyclosporin A to be sufficient in most high-risk cases.
authors.affiliation: Univ.-Augenklinik Düsseldorf.
authors.forename: V
authors.initials: V
authors.lastname: Rossa
authors.forename: R
authors.initials: R
authors.lastname: Sundmacher
authors.forename: P
authors.initials: P
authors.lastname: Heering
mesh_terms: D000284:Administration, Oral; D003316:Corneal Diseases / Q000601:surgery*; D003318:Corneal Opacity / Q000517:prevention & control; D016039:Corneal Transplantation / Q000379:methods*; D003524:Cyclosporins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D003524:Cyclosporins
vernacular_title: Systemische Ciclosporin A-Prophylaxe bei Risiko-Keratoplastiken.