[Immunoglobulin E in ankylosing spondylarthritis].
Ankylosing spondylarthritis (AS) patients (n-95) were examined for IgE concentrations using radioimmunoassay (commercial kits "Pharmacia"). Elevated IgE concentrations (greater than 100 Ku/l) were recorded in 16% out of 45 patients with central AS and in 40% out of 50 patients with peripheral AS (p less than 0.05). High IgE levels showed frequent association with a CIC rise and extraarticular manifestations (uveitis, focal nephritis). It is suggested that AS extraarticular signs arise in response to vascular affection due to IgE overproduction and formation of IgE-containing immune complexes.
Guseĭnov
N I
NI
Agababova
E R
ER
Nasonov
E L
EL
Lebedin
Iu S
IuS
Pospelov
L E
LE
Baenskiĭ
A V
AV
D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D011863:Radioimmunoassay; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*
D007074:Immunoglobulin G
Immunoglobulin E pri ankiloziruiushchem spondiloartrite.