[Changes in phosphatidylinositol levels in the blood and its components in patients with leukemia].
Continuous thin-layer chromatography was used in the assay of phosphatidylinositol (PI) content in the blood and its fragments. A significant reduction in the level of these compounds was recorded in leukemia patients as compared to that in normal donors and anemia patients. The reduction of PI level in the blood may evidence that the enzymatic systems of the blood cells have partially lost their capacity for maintaining the homeostasis of these compounds. The treatment of leukemia patients with lanvis, myleran and chlorambucil improved the general condition of the patients and normalized their clinico-laboratory parameters. A significant rise of PI level in the blood and its fragments as compared to the levels before the treatment was observed in these patients. The data obtained could be used in clinical practice for complex diagnosis of leukemia as well as for the patient follow-up during the treatment with varying drugs.
Sliusar'
N N
NN
Kargapolov
A V
AV
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy; D007962:Leukocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008875:Middle Aged; D010716:Phosphatidylinositols / Q000097:blood*; D013268:Stimulation, Chemical
D010716:Phosphatidylinositols
Izmenenie soderzhaniia fosfatidilinozitov v krovi i ee fragmentakh u bol'nykh leĭkozami.