[The role of the serotoninergic system of the brain in cimetidine-stimulated prolactin secretion].
Pharmacological studied were made on serotoninergic drugs (5-hydroxytryptophane, metisergid and p-chlorphenylalanin) to clarify mechanisms of cymetidine-stimulating secretion of prolactin. The experiments were carried out on white male rats at two stages: the first stage, in which dose-dependent influence of cymetidine on the release of prolactin was determined; and second stage, in which studies with indicated serotoninergic drugs after their 5-day administration were made on prolactin content after treatment with cymetidine in two doses of 20 mg/kg and 80 mg/kg of body mass. Prolactin content was determined in sera of male rats by a radioimmunological method. The results showed the influence of drugs--agonists and antagonists of serotonine on the release of prolactin after cymetid action and gave foundation to discuss them as a possible serotoninergic mechanism after cymetidine-stimulating secretion of prolactin. The results indicate the possibilities for clinical trial of serotoninergic drugs as correction of the side effect of cymetidine on prolactin secretion.
Boiadzhieva
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002927:Cimetidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011388:Prolactin / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D011985:Receptors, Serotonin; D002927:Cimetidine; D011388:Prolactin
Prouchvaniia vŭrkhu na serotoninergichnata sistema na mozŭka pri tsimetidinstimuliranata sekretsiia na prolaktin.