[Effect of dalargin on repair capacity of gastroduodenal mucosa in patients with duodenal ulcer].
Changes in the number of DNA-synthesizing nuclei of gastroduodenal mucosa in duodenal ulcer were monitored for patients treated with dalargin versus standard therapy (spasmolytics and antacids). In contrast to the standard treatment, dalargin 20-day administration produced a significant increase in the index of 3H-thymidine-labelled epithelial nuclei in fundal and duodenal bulb mucosa. The capacity for activating DNA synthesis in gastroduodenal mucosa may represent an essential mechanism of dalargin therapeutic action.
Timoshin
S S
SS
Alekseenko
S A
SA
Shtuka
A A
AA
D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D016099:Endoscopy, Gastrointestinal; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D012016:Reference Values; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na reparativnuiu sposobnost' gastroduodenal'noĭ slizistoĭ obolochki u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.