title: [Anti-inflammatory effects of verapamil, nifedipine and nicardipine].
abstract: Anti-inflammatory effects of calcium antagonists verapamil (Ver), nifedipine (Nif) and nicardipine (Nic) were compared. They all produced significant inhibitions in acute and chronic inflammatory models in a dose-dependent manner. The ED30 in the capillary permeability were: Ver 18, Nif 12 and Nic 8 mg/kg, respectively. In the xylene-induced swelling of mouse ears, the ED30 were: Ver 39, Nif 14, and Nic 25 mg/kg, respectively. In the carrageenan paw edema of mice, and in the acetic acid-induced pleurisy and cotton granuloma of rats these drugs inhibited inflammatory responses at 5 or 10 mg/kg. Nif showed a greater effect than Ver and Nic on the paw edema, and Ver showed greater effects than NIf and Nic on the pleurisy and granuloma. At 10 mg/kg they depressed the PGE2 content measured by radioimmunoassay in inflammatory tissues of carrageenan paw edema of mice.
authors.affiliation: Department of Pharmacology, Xinjiang Medical College, Urümqi, China.
authors.forename: W R
authors.initials: WR
authors.lastname: Chen
authors.forename: Y X
authors.initials: YX
authors.lastname: Yang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zheng
authors.forename: S Y
authors.initials: SY
authors.lastname: A
authors.forename: F
authors.initials: F
authors.lastname: Liu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002199:Capillary Permeability / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000378:metabolism; D008297:Male; D051379:Mice; D009529:Nicardipine / Q000494:pharmacology*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014700:Verapamil; D009529:Nicardipine; D009543:Nifedipine; D015232:Dinoprostone