title: [T and B lymphocytes and serum alpha 1-antitrypsin activity in children with bronchial asthma treated with broncho-vaxom].
abstract: The aim of this study was to evaluate an effect of Broncho-Vaxom treatment on T and B lymphocytes and serum alpha 1AT in children treated at "Zuch" sanatorium in Szczawno-spa. The trial involved 46 school aged children suffering from infectious or infectious-atopic asthma. The post-Broncho-Vaxom treatment values for T lymphocytes were significantly higher in infectious, and significantly lower for B lymphocytes in infectious-atopic asthma. Serum alpha 1AT activity in children suffering from infectious asthma decreased significantly after the treatment. A correlation between the efficacy of the treatment and the lymphocyte percentage was observed. In children with very effective clinical results of Broncho-Vaxom treatment, the significant increase in T lymphocyte, and decrease in B lymphocyte populations was observed. Changes in T and B lymphocyte percentage were analysed in respect to alpha 1AT pre-treatment activity. In children with high alpha 1AT value, T lymphocytes after the treatment increased significantly in infectious, and B lymphocytes decreased significantly in infectious-atopic group.
authors.affiliation: I Katedry i Kliniki Pediatrii AM we Wrocławiu.
authors.forename: J
authors.initials: J
authors.lastname: Wartenberg
authors.forename: J
authors.initials: J
authors.lastname: Lewandowska
authors.forename: M
authors.initials: M
authors.lastname: Pilarek
authors.forename: D
authors.initials: D
authors.lastname: Piltz
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001402:B-Lymphocytes / Q000187:drug effects*; D001419:Bacteria; D002457:Cell Extracts; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000095983:Bacterial Lysates
chemical_list: D000276:Adjuvants, Immunologic; D002457:Cell Extracts; D000515:alpha 1-Antitrypsin; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates
vernacular_title: Limfocyty T i B i aktywność alfa-1-antytrypsynowa u dzieci chorych na dychawice oskrzelowa leczonych preparatem Broncho-Vaxom.