title: Glutaric aciduria type II: autopsy study of a case with electron-transferring flavoprotein dehydrogenase deficiency.
abstract: An autopsy study of glutaric aciduria type II in a 62-day-old Japanese boy is presented. The diagnosis was made by analysis of organic acids in the urine. Immunoblot analysis of liver homogenate confirmed the diagnosis, revealing absence of electron-transferring flavoprotein dehydrogenase. The major findings were fatty changes of variable degree in many organs and tissues, the most severe being found in cardiac myocytes, hepatocytes, renal tubular epithelium, and skeletal muscle fibers. Other pertinent findings included multicystic and dysplastic kidney, pulmonary alveolar proteinosis, and spongiosis and gliosis of the spinal cord. The thymus was markedly depleted, and lymphocytes in the lymph nodes were mainly B cells. Although some of these changes may have been secondary to the sepsis and immunosuppression complicating 2 months of intensive care, the abnormal organic acid metabolism with severe acidosis may have been a significant contributing factor.
authors.affiliation: Department of Pathology, Nagoya City University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kamiya
authors.forename: T
authors.initials: T
authors.lastname: Eimoto
authors.forename: H
authors.initials: H
authors.lastname: Kishimoto
authors.forename: T
authors.initials: T
authors.lastname: Tsudzuki
authors.forename: H
authors.initials: H
authors.lastname: Morishita
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: S I
authors.initials: SI
authors.lastname: Goodman
authors.forename: F E
authors.initials: FE
authors.lastname: Frerman
mesh_terms: D000138:Acidosis / Q000145:classification / Q000151:congenital* / Q000378:metabolism; D004579:Electron Transport; D044927:Electron-Transferring Flavoproteins; D044943:Fatty Acid Desaturases / Q000172:deficiency*; D005977:Glutarates / Q000652:urine*; D006801:Humans; D007223:Infant; D007506:Iron-Sulfur Proteins; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008661:Metabolism, Inborn Errors / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000172:deficiency*; D000587:Oxidoreductases Acting on CH-NH Group Donors
chemical_list: D044927:Electron-Transferring Flavoproteins; D005977:Glutarates; D007506:Iron-Sulfur Proteins; D009097:Multienzyme Complexes; D044943:Fatty Acid Desaturases; D000587:Oxidoreductases Acting on CH-NH Group Donors; C023120:electron-transferring-flavoprotein dehydrogenase; C035736:glutaric acid