The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Aceclofenac is a new phenylacetic acid derivative provided with marked antiinflammatory, antiarthritic, analgesic and antipyretic activities in animal experimental models. While maintaining its potency Aceclofenac demonstrates better gastric tolerance and consequently offers greater potential security than other highly active agents such as Indomethacin and Diclofenac.
Grau
M
M
Department of Pharmacology and Toxicology, Prodesfarma Research Center, Sant Just Desvern, Barcelona, Spain.
Montero
J L
JL
Guasch
J
J
Felipe
A
A
Carrasco
E
E
Juliá
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D009288:Naproxen / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D009288:Naproxen; D010653:Phenylbutazone; C056498:aceclofenac; D007213:Indomethacin