Morphine inhibits the ethanol-induced gastric damage in rats.
Morphine (0.1-2 mg/kg)--administered either orally (p.o.) or subcutaneously (s.c.)--inhibited the acidified ethanol-induced gastric damage in a dose-dependent manner. However, when morphine was given intracerebroventricularly no inhibition was observed. Naloxone (0.5 mg/kg, s.c. and p.o.) blocked the protective action of morphine. Bremazocine (0.05-1 mg/kg, p.o., s.c.) did not influence the ethanol-induced mucosal necrosis in a significant manner, but decreased (in the dose of 0.5 mg/kg, p.o., s.c.) the protective action of morphine. Morphine (1 mg/kg, s.c.) also reduced the ethanol-induced enhanced vascular permeability of gastric mucosa and naloxone (0.5 mg/kg, s.c.) inhibited this effect too. Indomethacin (10 mg/kg, p.o.) and the sulfhydryl alkylator N-ethylmaleimid (50 mg/kg, s.c.) decreased the protective action of morphine, suggesting a possible involvement of mucosal prostaglandins and sulfhydryls in the effect of morphine on ethanol-induced gastric erosions.
Gyires
K
K
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001575:Benzomorphans / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D000431:Ethanol / Q000037:antagonists & inhibitors*; D005033:Ethylmaleimide / Q000494:pharmacology; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D011453:Prostaglandins / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000700:Analgesics; D001575:Benzomorphans; D011453:Prostaglandins; D009270:Naloxone; D000431:Ethanol; D009020:Morphine; C027248:bremazocine; D005033:Ethylmaleimide; D007213:Indomethacin