The initiation of chromosomal DNA replication in eukaryotes.
Eukaryotic DNA replication initiates at many sites on each chromosome during the S phase of the cell cycle. Each origin of replication lies in a unique chromosomal environment and can be regulated in different cell types both at the level of utilization and the time of initiation during S phase. In this review, we examine the control and the mechanism of eukaryotic origin function.
Diffley
J F
JF
Cold Spring Harbor Laboratory, NY 11724.
Stillman
B
B
D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000648:ultrastructure; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D016196:S Phase / Q000235:genetics