[Synthesis and pharmacologic testing of 1-oxo-pyridazine and 1-oxo-phthalazine-2-acetic acid derivatives].
The title compounds, starting from variously substituted beta-benzoylpropionic or beta-benzoylbenzoic acids, were prepared by cyclocondensation with alpha-ethylhydrazinoacetate monohydrochloride and subsequent alcaline hydrolysis or aminolysis of the 2-carbethoxymethyl-1,2,5,6-tetrahydro-1-oxo-pyridazines or 1,2-dihydro-1-oxo-phthalazines respectively. The 1-oxo-phthalazines 42 and 34 have a weak anticonvulsive effect. Like a large number of the other synthezized compounds, they show a central sedative component and are relatively nontoxic.
Horn
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Sektion Biowissenschaften der Universität Leipzig.
Morgenstern
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Unverferth
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D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000085:Acetates; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D010793:Phthalazines; D011724:Pyridazines
Synthese und pharmakologische Testung von 1-oxo-pyridazin-bzw. 1-Oxo-phthalazin-2-essigs5aaurederivaten.