title: Atrophy of compartments of rat lymph nodes related to an entry of lethally altered lymphocytes.
abstract: This paper reports the occurrence of an accumulation of lethally altered lymphocytes in the subcapsular sinus of a compartment or compartments of some lymph nodes, an unusual feature best developed in nodes of the mesenteric site in aging athymic animals. Many of these cells are rod-like. In other compartments, similar lymphocytes occurred at various depths in the nodal parenchyma. This was accompanied by the disappearance of a compartment's populations of normal lymphoid cells. The observations reveal that lymphocytes, altered in a tissue, may reach the subcapsular sinus of the draining node compartment and migrate into its parenchyma which then undergoes atrophy. The likely involvement of mast cells is discussed.
authors.affiliation: Départment d'Anatomie, Université de Montréal, Québec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Sainte-Marie
authors.forename: F S
authors.initials: FS
authors.lastname: Peng
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement / Q000502:physiology; D008198:Lymph Nodes / Q000473:pathology* / Q000503:physiopathology; D008214:Lymphocytes / Q000473:pathology* / Q000502:physiology; D008407:Mast Cells / Q000473:pathology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains