UV-irradiation potentiates the antimutagenicity of p-aminobenzoic and p-aminosalicylic acids in Salmonella typhimurium.
UV-irradiation (254 nm, 10 or 20 J/cm2) of p-aminobenzoic acid (PABA) and p-aminosalicylic acid (NaPAS) potentiated their antimutagenicity towards N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in Salmonella typhimurium. Their inhibitory action towards the formation of the mutagen N-methyl-N-nitrosourea from the nitrosation mixture of N-methylurea and nitrite was also increased by UV-irradiation. In contrast, UV-irradiated PABA exhibited no inhibitory effects towards the mutagenicity of sodium azide or 3-azidoglycerol. Neither PABA nor NaPAS nor their UV-irradiation products were themselves mutagenic in the Ames assay.
Gichner
T
T
Institute of Experimental Botany, Prague, Czechoslovakia.
Baburek
I
I
Velemínský
J
J
Kappas
A
A
D010129:4-Aminobenzoic Acid / Q000494:pharmacology* / Q000528:radiation effects; D010131:Aminosalicylic Acid / Q000494:pharmacology* / Q000528:radiation effects; D001386:Azides / Q000633:toxicity; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D008770:Methylnitrosourea / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D011409:Propylene Glycols / Q000633:toxicity; D012486:Salmonella typhimurium / Q000235:genetics*; D019810:Sodium Azide; D013268:Stimulation, Chemical; D014466:Ultraviolet Rays
D001386:Azides; D009153:Mutagens; D011409:Propylene Glycols; D008769:Methylnitronitrosoguanidine; D010131:Aminosalicylic Acid; D008770:Methylnitrosourea; C052086:azidoglycerol; D019810:Sodium Azide; D010129:4-Aminobenzoic Acid