title: The effects of acute moderate exercise on leukocyte and lymphocyte subpopulations.
abstract: The extent and duration of changes in circulating leukocyte and lymphocyte subpopulations, cortisol, and catecholamines were examined in 12 women who walked 45 min at 60% VO2max in a laboratory setting. A two-factor, 2 x 6 design with repeated measures on both factors was utilized. The first factor was condition (exercise and rest), and the second factor was time (six points of measurement over a 24-h period), with treatment order counterbalanced. The 45-min walk, in comparison with rest in a seated position, was associated with a significant but moderate leukocytosis and lymphocytosis immediately following the walk. The leukocytosis was still evident after 3 h of recovery and was primarily due to a neutrophilia. The change in lymphocyte count, relative to baseline levels and the control condition, lasted less than 1.5 h, with an increase in the natural killer (CD16 and/or CD56) and cytotoxic T cell component (CD3 and CD16 and/or CD56) (NKCT) representing approximately two-thirds of the lymphocytosis and T cells (CD5) the other third. A significant decrease in the CD4:CD8 ratio was seen, with cytotoxic/suppressor (CD8) cells increasing and helper/inducer (CD4) cells demonstrating little change in comparison with baseline. This seems to have been due to a subpopulation of CD8 (low density antigen) cells, probably natural killer cells. The 45-min walk had no effect on plasma cortisol and epinephrine levels relative to the rest condition but was associated with a moderate increase in norepinephrine.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Health Science, School of Public Health, Loma Linda University, CA.
authors.forename: D C
authors.initials: DC
authors.lastname: Nieman
authors.forename: S L
authors.initials: SL
authors.lastname: Nehlsen-Cannarella
authors.forename: K M
authors.initials: KM
authors.lastname: Donohue
authors.forename: D B
authors.initials: DB
authors.lastname: Chritton
authors.forename: B L
authors.initials: BL
authors.lastname: Haddock
authors.forename: R W
authors.initials: RW
authors.lastname: Stout
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000328:Adult; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D007962:Leukocytes; D008214:Lymphocytes; D008218:Lymphocytosis / Q000209:etiology; D008875:Middle Aged; D010101:Oxygen Consumption; D011897:Random Allocation