A controlled study for gender selection.
OBJECTIVE
To evaluate the success for gender selection of insemination with a sample of semen separated by a serum albumin density separation gradient.


METHODS
We retrospectively compared the gender outcome of conceptions of couples who conceived spontaneously with those who conceived secondary to an insemination with separated semen.


METHODS
Private practice of one author (M.A.K.).


METHODS
The study group consisted of 48 pregnancies of couples who conceived by the separation technique. The control group consisted of 46 pregnancies of couples who initially presented for consultation for gender selection but conceived spontaneously.


METHODS
In the study group, one timed intrauterine insemination with separated semen was performed per cycle, with a mean of 2.3 cycles per couple. Patients desiring a female were also treated with clomiphene citrate and human chorionic gonadotropin.


METHODS
The gender outcome of the pregnancies of the two groups was evaluated based on the known desired gender.


RESULTS
The success rate for conceiving a desired male was 56.5% in the study group and 60.9% in the control group (P = 1.000). Of couples seeking females, 78.6% of the procedure group versus 35.3% of the control group were successful (P = 0.019).


CONCLUSIONS
This study debates the albumin gradient as definitively enriching the proportion of Y-bearing sperm after in vitro separation.
Jaffe
S B
SB
College of Physicians and Surgeons of Columbia University, New York, New York.
Jewelewicz
R
R
Wahl
E
E
Khatamee
M A
MA
D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient; D005260:Female; D006801:Humans; D007317:Insemination, Artificial, Homologous / Q000379:methods; D008297:Male; D012189:Retrospective Studies; D012743:Sex Preselection / Q000379:methods*; D013094:Spermatozoa