Transforming growth factor-beta inhibits lactogenic hormone induction of beta-casein expression in HC11 mouse mammary epithelial cells.
HC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms of beta-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-beta (TGF-beta) can inhibit beta-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-beta also inhibits DNA synthesis of HC11 cells. These findings suggest a possible role of TGF-beta as an inhibitor of functional differentiation in the mammary gland.
Mieth
M
M
Department of Cell Biology, Academy of Sciences, Berlin-Buch, GDR.
Boehmer
F D
FD
Ball
R
R
Groner
B
B
Grosse
R
R
D000818:Animals; D002364:Caseins / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D003907:Dexamethasone / Q000494:pharmacology; D004847:Epithelial Cells; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011388:Prolactin / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000494:pharmacology* / Q000502:physiology
D002364:Caseins; D006133:Growth Substances; D016212:Transforming Growth Factor beta; D003907:Dexamethasone; D011388:Prolactin; D004247:DNA