[Wilson's disease in East Germany: in retrospect and perspectives -- an evaluation].
Wilson's disease is an autosomal recessive inherited metabolic disorder due to a disturbance of copper metabolism. Although the primary genetic defect is not known a longlife treatment is necessary for establishing a negative copper balance by removing the metal of the abnormal body stores. Experiences in handling with this disease in our country over a period of 20 years are reported. Especially epidemiologic findings, the diagnostic procedures and the strategies in therapeutic regimes are discussed. Future advances in genomic diagnostics are mentioned.
Lössner
J
J
Klinik für Neurologie der Karl-Marx-Universität Leipzig.
Bachmann
H
H
Siegemund
R
R
Kühn
H J
HJ
Günther
K
K
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005859:Germany, East / Q000453:epidemiology; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D015994:Incidence
Wilsonsche Erkrankung in der DDR: Rückblick und Ausblick--eine Bilanz.