Gustative sensitivity to glucose improvement in diabetics after sulphonylurea.
Sensitivity of the gustatory receptor to glucose has been studied in 20 diabetic patients given tolbutamid and glibenclamid as treatment or examined in the tolbutamid tolerance test (TTT). Tolbutamid and glibenclamid treatment significantly improves the diabetic taste for glucose, both for detection threshold (DT) (p less than 0.01) and recognition threshold (RT) (p less than 0.001). Also in TTT there is a significant improvement of taste reception: DT falls at 2 h (p less than 0.05), RT falls more slowly at 3 h (p less than 0.05). There is no direct correlation between perception for sweet and glycemia and insulinemia increase in TTT. Our results suggest that glucose receptivity is dependent on a receptor glucose-insulin complex, and tolbutamid (and glibenclamid) besides its capacity to stimulate insulin secretion has even a peripheral action, at this receptor level.
Pereţianu
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D
Department of Endocrinology and Applied Immunology, Hospital of the 4th District, Bucharest.
Deleanu
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A
Tănase
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D013649:Taste / Q000187:drug effects* / Q000502:physiology; D013652:Taste Threshold / Q000187:drug effects / Q000502:physiology; D014044:Tolbutamide
D001786:Blood Glucose; D007328:Insulin; D013453:Sulfonylurea Compounds; D014044:Tolbutamide