title: [Reversal of high-dose fentanyl anesthesia by naloxone: analysis of factors attenuating respiratory and hemodynamic responses to naloxone].
abstract: The respiratory and hemodynamic responses to postoperative reversal by naloxone of high-dose fentanyl anesthesia were studied in 101 patients after open heart surgery. Respiratory and hemodynamic changes after drip infusion of naloxone were minimum. Change of systolic blood pressure (BPs), mean blood pressure (BPm), CVP and PO2 were statistically significant. BPs increased for 3.8 +/- 14.0 mmHg, BPm increased for 1.6 +/- 8.2 mmHg. CVP decreased for 0.4 +/- 2.1 mmHg, and PO2 decreased for 8.6 +/- 3.4 mmHg. Severe side effect was not observed. Multi-factorial analysis revealed that the abrupt recovery of consciousness from anesthesia and acidosis were the most important factors that attenuate hemodynamic response to naloxone.
authors.affiliation: Department of Anesthesia and Intensive Care, Hiroshima City Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Takatori
authors.forename: T
authors.initials: T
authors.lastname: Asanobu
authors.forename: S
authors.initials: S
authors.lastname: Kawakami
authors.forename: H
authors.initials: H
authors.lastname: Naito
authors.forename: T
authors.initials: T
authors.lastname: Higashi
authors.forename: K
authors.initials: K
authors.lastname: Kouno
authors.forename: H
authors.initials: H
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Kurasako
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Tada
mesh_terms: D000762:Anesthesia Recovery Period; D005283:Fentanyl / Q000037:antagonists & inhibitors*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009270:Naloxone / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects
chemical_list: D009270:Naloxone; D005283:Fentanyl