[Delayed reaction in asthma].
IgE mediated type 1 hypersensitivity induces an immediate phase, during the minutes that follow contact with the allergen and is very often associated with a late phase that occurs during the hours that follow contact. The late phase of asthma induced by an IgE--dependent mechanism is linked with a cellular activation (lymphocytes, eosinophils) and release of different mediators (Paf Acether, LTB4, ECFA, MBP, EcP) from those of the immediate phase. Corticosteroids are well known as inhibitors of the late phase. Like cromoglycate, AZELASTINE inhibits both the immediate and late phases.
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School of Medicine, Department of Pediatrics, San Francisco, CA 94143.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D004285:Dogs; D004804:Eosinophils / Q000378:metabolism; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000276:immunology; D008689:Methacrylates / Q000627:therapeutic use; D009504:Neutrophils / Q000378:metabolism; D010793:Phthalazines / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D008689:Methacrylates; D010793:Phthalazines; D007073:Immunoglobulin E; C034364:ozagrel; C020976:azelastine
La réaction retardée dans l'asthme.