Alpha 1-antichymotrypsin supports short-term survival of cerebral neurons in culture.
alpha 1-Antichymotrypsin (ACT) is a component of the amyloid deposits in Alzheimer's disease. To elucidate its biological activities in the central nervous system, dissociated cultures of rat cerebral neurons were grown in a serum-free medium containing ACT. The addition of ACT (0.1-1 microgram/ml) enhanced survival of microtubule-associated protein 2-immunoreactive neurons under the culture conditions examined.
Mizuguchi
M
M
Department of Medicine, University of British Columbia, Vancouver, Canada.
Kim
S U
SU
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D000514:alpha 1-Antichymotrypsin / Q000502:physiology*
D008869:Microtubule-Associated Proteins; D000514:alpha 1-Antichymotrypsin