[Effects of alminoprofen on the allergic reactions].
The effects of alminoprofen, a nonsteroidal anti-inflammatory agent, on the experimental animal models of allergic reactions were examined and compared with those of ibuprofen. Alminoprofen at 30 mg/kg given intraduodenally significantly suppressed passive anaphylactic bronchoconstrictions, while ibuprofen did not at the same doses. In vitro studies revealed that alminoprofen, in contrast to ibuprofen, exerted an inhibitory effect on arachidonate 5-lipoxygenase activity which initiates the bio-synthesis of leukotrienes. Alminoprofen inhibited arachidonic acid-induced ear edema in mice and homologous passive cutaneous anaphylaxis in rats at high doses, while ibuprofen did not at the high doses. From its characteristic feature of inhibitory effects on 5-lipoxygenase activity and the experimental model of type I allergic reaction, it is suggested that alminoprofen is a new type of nonsteroidal anti-inflammatory agent.
Kojima
E
E
Central Research Laboratories, Fujirebio, Inc., Hachioji, Japan.
Tamura
N
N
Higashide
Y
Y
Lee
B
B
Yamaura
T
T
Ohnishi
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D016084:Bronchoconstriction / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D006168:Guinea Pigs; D007052:Ibuprofen / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C027953:alminoprofen; D001094:Arachidonate 5-Lipoxygenase; D007052:Ibuprofen