[Pharmacological correction of ketamine-impaired spatial memory of rats].
Ketamine in dose 10 mg/kg increased the number of erroneous choices of rats with spatial strategy and didn't effect searching accuracy of rats with non-spatial strategy in 8-arm radial maze. Ketamine in doses 1 and 5 mg/kg disrupted rat short-term memory in delayed response reaction. Physostigmine and aspartic acid, but not haloperidol, diminished ketamine amnesia, therefore ketamine impaired the interaction of cholinergic and glutamate/aspartatergic neurons of hippocampal areas.
Kovalev
G V
GV
Sazhin
V A
VA
Kuleshova
I P
IP
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D007649:Ketamine / Q000009:adverse effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D013037:Spatial Behavior
D001224:Aspartic Acid; D007649:Ketamine; D010830:Physostigmine; D006220:Haloperidol
Farmakologicheskaia korrektsiia narushennoĭ ketaminom prostranstvennoĭ pamiati krys.