The effect of prostanoids on the function of human eosinophils.
The effects of prostanoids on eosinophil cationic protein (ECP) release and eosinophil migration have been measured. ECP release was inhibited by prostanoids active on DP and EP receptors. In contrast the DP agonist protaglandin D2 enhanced eosinophil migration.
Butchers
P R
PR
Department of Peripheral Pharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
Vardey
C J
CJ
D001798:Blood Proteins / Q000378:metabolism*; D002465:Cell Movement / Q000187:drug effects; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D011453:Prostaglandins / Q000494:pharmacology*; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D011453:Prostaglandins; D012260:Ribonucleases