Effect of bacterial endotoxin on placentation of rats.
The effect of bacterial endotoxin on placentation in rats was studied on 160 CFY pregnant rats. Based on this experiment, it was concluded that (i) the endotoxin (1 mg/animal i.p.) inhibited placentation (in 90% of animal). (ii) The endotoxin-induced fetopathy almost exclusively resulted in abortion. (iii) The fetuses reacted to endotoxin with relatively the same degrees of susceptibility. (iv) The growth of surviving fetuses seemed to be undisturbed. (v) Endotoxin-induced damages in mothers first of all depend on the individual susceptibility of these pregnant animals and (vi) the endotoxin tolerance induced by radio-detoxified endotoxin (TOLERIN) significantly protects both the mothers and the fetuses against endotoxin challenge.
Szöcs
G
G
Department of Radiation Application, Fréderic Joliot-Curie National Research Institute of Radiobiology and Radiohygiene, Budapest, Hungary.
Csordás
T
T
Bertók
L
L
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology / Q000528:radiation effects*; D004926:Escherichia coli; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D008070:Lipopolysaccharides / Q000009:adverse effects*; D010929:Placentation / Q000187:drug effects*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology*; D051381:Rats
D004731:Endotoxins; D008070:Lipopolysaccharides; C010797:tolerin