title: Hypophosphatemic rickets with hypocalciuria following long-term treatment with aluminum-containing antacid.
abstract: We present what we believe is the first case of rickets following prolonged treatment with aluminum containing antacids that bind phosphate, in an 18-year-old mentally retarded boy with cerebral palsy and spastic quadriplegia. As expected, serum calcitriol was increased and urinary phosphate excretion was very low. However, in contrast to all published cases of antacid induced hypophosphatemic osteomalacia in adults, despite a substantial increase in bone resorption reflected by urinary total hydroxyproline excretion, urinary calcium excretion was low rather than high, and significant hypocalcemia occurred after antacids were ceased and a phosphate salt administered. We suggest that the skeleton was so under-mineralized because of growth during prolonged phosphate deficiency, possibly augmented by anticonvulsant administration and immobilization, that increased bone resorption did not release enough calcium to cause hypercalciuria, or to prevent hypocalcemia during resumption of normal mineralization.
authors.affiliation: Department of Medicine, Henry Ford Hospital, Detroit, Michigan.
authors.forename: J
authors.initials: J
authors.lastname: Foldes
authors.forename: R
authors.initials: R
authors.lastname: Balena
authors.forename: A
authors.initials: A
authors.lastname: Ho
authors.forename: A M
authors.initials: AM
authors.lastname: Parfitt
authors.forename: M
authors.initials: M
authors.lastname: Kleerekoper
mesh_terms: D000293:Adolescent; D000536:Aluminum Hydroxide / Q000009:adverse effects*; D000863:Antacids / Q000009:adverse effects*; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000652:urine*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008607:Intellectual Disability; D008276:Magnesium Hydroxide / Q000009:adverse effects*; D008297:Male; D010710:Phosphates / Q000172:deficiency*; D011859:Radiography; D012279:Rickets / Q000139:chemically induced* / Q000000981:diagnostic imaging; D012841:Simethicone / Q000009:adverse effects*
chemical_list: D000863:Antacids; D004338:Drug Combinations; D010710:Phosphates; C008570:aluminum hydroxide, magnesium hydroxide, simethicone drug combination; D000536:Aluminum Hydroxide; D012841:Simethicone; D002117:Calcitriol; D008276:Magnesium Hydroxide; D006909:Hydroxyproline; D002118:Calcium