Cimetidine and ranitidine may not cross-react to cause thrombocytopenia.
We report the case of a patient with peptic ulcer disease who developed cimetidine-induced thrombocytopenia. The thrombocytopenia resolved spontaneously following discontinuation of cimetidine, and did not recur with ranitidine. We concluded that cimetidine and ranitidine do not necessarily cross-react to induce thrombocytopenia. Thus the exclusion of both H2-blockers in the event that one has caused thrombocytopenia may not be justified.
Shalev
O
O
Department of Medicine, Hadassah University Hospital Mount Scopus, Jerusalem, Israel.
Seror
D
D
D000368:Aged; D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology; D011899:Ranitidine / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced*
D002927:Cimetidine; D011899:Ranitidine