Towards a new era: is coronary artery disease reversible?
There is increasing evidence that conventional lipid-lowering therapy can arrest the progression of coronary atherosclerosis. Trials are now under way to determine whether more radical reduction of low-density-lipoprotein cholesterol will reverse atherosclerosis and lead to regression of coronary lesions. The ability to effect such reductions has been markedly enhanced by the introduction into clinical practice of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Thompson
G R
GR
MRC Lipoprotein Team, Hammersmith Hospital, London, UK.
D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors