title: [Acidotropic effect of chelating agents on insulinocytes].
abstract: The acidotropic effect of chelates on insulocytes was demonstrated in experiments on dogs, cats, rabbits, rats, golden hamsters, and mice. On penetrating the cells these agents react with zinc and accumulate as complexes in the lysosome-segregation apparatus. The extent of damages occurring in the insulocytes in this case is determined by the amount of zinc bound by these agents.
authors.forename: V A
authors.initials: VA
authors.lastname: Eshchenko
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D002415:Cats; D006224:Cricetinae; D004230:Dithizone / Q000494:pharmacology*; D004285:Dogs; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008647:Mesocricetus; D051379:Mice; D011817:Rabbits; D051381:Rats; D015032:Zinc / Q000378:metabolism
chemical_list: D004230:Dithizone; D015032:Zinc
vernacular_title: Atsidotropnoe deĭstvie khelantov na insulotsity.