[Effect of histamine on the action potential of the maxillary nerve in rabbits].
The significant enhancement of action potential as recorded from rabbit maxillary nerve with topically applied 1.0 mmol/L histamine on the nasal mucosa was completely blocked by pretreatment with diphenhydramine (H1 antagonist) but not with cimetidine (H2 antagonist). This fact gives new support to the concept that histamine exerts its pathological effect on nasal mucosa at least partly via an afferent nervous pathway of the trigeminal nerve.
Yang
P
P
First Affiliated Hospital, Hunan Medical University, Changsha.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004525:Efferent Pathways / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D008442:Maxillary Nerve / Q000502:physiology*; D009297:Nasal Mucosa / Q000187:drug effects; D011817:Rabbits; D014276:Trigeminal Nerve / Q000502:physiology
D002927:Cimetidine; D006632:Histamine; D004155:Diphenhydramine