[Effect of antilymphocyte globulin on growth and erythroid differentiation of K-562 cells].
The influence of antilymphocytic globulin (ALG) on the proliferative activity and erythroid differentiation of erythromyeloid K-562 cells was studied. It has been established that ALG produces a dose-dependent inhibiting effect (20-150 micrograms of ALG/ml) on the proliferative activity of K-562 cells and induces erythroid differentiation of these cells that does not depend on the concentration of ALG used in the test. Pretreatment of K-562 cells with ALG increases their sensitivity to the following growth-inhibiting action of cytosine-arabinoside.
Blinov
M N
MN
Luganova
I S
IS
Vartanian
N L
NL
D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000473:pathology*; D006131:Growth Inhibitors; D006801:Humans; D066298:In Vitro Techniques; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000473:pathology*
D000961:Antilymphocyte Serum; D003470:Culture Media; D006131:Growth Inhibitors
Vliianie antilimfotsitarnogo globulina na rost i éritroidnuiu differentsirovku kletok linii K-562.