title: [Neurological involvement as manifestation of Behçet's disease. 4 clinical case reports].
abstract: We report four patients with Behçet's disease characterized by initial and predominant neurological signs and symptoms. In three cases, a clinical picture of relapsing meningoencephalitis preceded the appearance of the classical signs of the disease for several months or years; in the fourth case, an acute febrile aseptic meningitis coincided with the development of bipolar aphthosis and uveitis. Disease activity was linked to a blood inflammatory syndrome and neutrophilic leucocytosis. Acute phases were associated with CSF mixed pleocytosis and high protein content. Brain CT scans and MRI were very effective to detect lesions which are mainly located in the brain stem and basal ganglia. High-dose corticosteroids and, in cases of relapses, immunosuppressive drugs were required to treat these severe forms of Behçet's disease.
authors.affiliation: Service de Neurologie, UCL, Bruxelles.
authors.forename: M
authors.initials: M
authors.lastname: Gille
authors.forename: C J
authors.initials: CJ
authors.lastname: Sindic
authors.forename: P F
authors.initials: PF
authors.lastname: Laterre
authors.forename: P
authors.initials: P
authors.lastname: De Hertogh
authors.forename: J M
authors.initials: JM
authors.lastname: Hotermans
authors.forename: I
authors.initials: I
authors.lastname: Selak
authors.forename: C
authors.initials: C
authors.lastname: Laterre
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000134:cerebrospinal fluid / Q000150:complications* / Q000175:diagnosis; D002556:Cerebrospinal Fluid Proteins; D005260:Female; D006801:Humans; D008297:Male; D008581:Meningitis / Q000209:etiology*; D008590:Meningoencephalitis / Q000209:etiology*; D008875:Middle Aged; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000150:complications; D014605:Uveitis / Q000150:complications
chemical_list: D002556:Cerebrospinal Fluid Proteins
vernacular_title: Atteintes neurologiques révélatrices d'une maladie de Behçet. Quatre observations cliniques.