[Biologic action of promestriene on the genital tract of the castrated rat].
The study assessed the activity of promestrien administered by a local vaginal route in 16 rats castrated 60 days previously. The dose used was 5 mg per day for 10 days. Following treatment, animals were sacrificed and histological analyses revealed a remarkable proliferation of the vaginal epithelium, inhibition and restored trophism of the strome, whereas no estrogen stimulus was observed at the level of uterine mucous. This confirms the exclusively local action of promestrien which does not provoke undesirable side effects on other segments of the genital tract, and allows the therapeutic use of the hormone in different gynaecological pathologies.
Borrelli
A L
AL
I Facoltà di Medicina e Chirurgia, III Cattedra di Clinica Ostetrica e Ginecologica, Università degli Studi di Napoli.
Casolaro
A M
AM
Esposito
G
G
Berlingieri
D
D
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D009092:Mucous Membrane / Q000187:drug effects; D051381:Rats; D011960:Receptors, Estrogen / Q000502:physiology*; D014621:Vagina / Q000187:drug effects*
D011960:Receptors, Estrogen; D004958:Estradiol; C013657:promestriene
Attività biologica del promestriene sul tratto genitale della ratta castrata.