[Studies on chemical protectors against radiation. XXX. Radioprotective substances of cnidii rhizoma].
Radiation protective effects of the methanol extract and its fractions of Cnidii Rhizoma on lethality and skin injury induced by X-irradiation were studied. As a result of these studies, it was observed that significant protective effects exist in both ether and water soluble portions prepared from the above methanol extract, and two of the active principles in the ether and water soluble ones were identified as ferulic acid and adenosine, respectively.
Ohta
S
S
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Sakurai
N
N
Sato
Y
Y
Inoue
T
T
Shinoda
M
M
D000241:Adenosine / Q000302:isolation & purification; D000818:Animals; D003373:Coumaric Acids / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D000432:Methanol; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents
D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D011837:Radiation-Protective Agents; C004999:ferulic acid; D000241:Adenosine; D000432:Methanol