Failure of demonstrated clinical efficacy of antibiotic-bonded continuous ambulatory peritoneal dialysis (CAPD) catheters.
Previous in vitro, in vivo, and a preliminary clinical report have demonstrated efficacy of noncovalently bonding antibiotics to the surface of continuous ambulatory peritoneal dialysis (CAPD) catheters in decreasing infectious complications. A larger prospective randomized clinical trial was completed. Eighty-six patients with chronic renal failure were enrolled in the study and randomized to receive either a surfactant treated or untreated control catheter. All catheters were soaked in cefoxitin at the time of insertion. Groups were comparable in terms of pre-existing illnesses, age, and gender. No differences were shown in the incidence of catheter-tract infections, peritonitis or mechanical complications. There was also no differences in microbiologic culture results. Therefore, it is concluded that this clinical trial did not demonstrate a reduction in catheter-related infectious complications by antibiotic bonding.
Trooskin
S Z
SZ
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.
Harvey
R A
RA
Lennard
T W
TW
Greco
R S
RS
D001424:Bacterial Infections / Q000517:prevention & control*; D002408:Catheters, Indwelling; D002440:Cefoxitin; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000295:instrumentation*; D010538:Peritonitis / Q000517:prevention & control*; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents
D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D002440:Cefoxitin; C009543:tridodecylmethylammonium