Correction of serious iron overload in a chronic hemodialysis patient by recombinant human erythropoietin and removal of red blood cells: confirmation by follow-up liver biopsy.
A chronic hemodialysis case, a 46-year-old woman with secondary hemosiderosis induced by parenteral iron and blood transfusion due to a refractory anemia, was effectively treated with recombinant human erythropoietin and the removal of red blood cells. The cumulative dose of the iron removed was 5,712 mg. Plasma ferritin decreased from 8,290 to 2,203 micrograms/l during 18 months. Concomitantly, liver histology performed before and after the therapy revealed a prominent regression of the deposited iron.
Onoyama
K
K
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka City, Japan.
Nakamura
S
S
Yamamoto
M
M
Kawadoko
T
T
Nanishi
F
F
Komoda
T
T
Murai
K
K
Fujishima
M
M
D000753:Anemia, Refractory / Q000628:therapy; D001706:Biopsy; D001803:Blood Transfusion; D004906:Erythrocyte Count; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006486:Hemosiderosis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007501:Iron / Q000009:adverse effects* / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects*
D011994:Recombinant Proteins; D004921:Erythropoietin; D005293:Ferritins; D007501:Iron