title: Near normalization of adolescent height with growth hormone therapy in very short children without growth hormone deficiency.
abstract: Ten prepubertal children with stature at or below the 1st percentile for height and without growth hormone deficiency received 0.3 U recombinant growth hormone per kilogram daily for 2 years before puberty. Their growth velocity increased from 4 +/- 0.3 cm/yr before treatment to 10.7 +/- 0.6 and 8.8 +/- 0.6 cm, respectively, during the first and second years of treatment, and then remained at 5.7 +/- 0.7 cm the year after the end of growth hormone administration. This resulted in a near normalization of adolescent height. Bone maturation paralleled chronologic age, and therefore the expected final height of the children increased by approximately 10 cm. Administration of growth hormone induced a reversible hyperinsulinemia, with moderate and transient changes in glucose metabolism. A prospective, randomized study, including an untreated cohort, will be needed to confirm the effects on final height and to determine the magnitude of the response in familial short stature.
authors.affiliation: Service d'Endocrinologie, Hôpital St Vincent de Paul, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Lesage
authors.forename: J
authors.initials: J
authors.lastname: Walker
authors.forename: F
authors.initials: F
authors.lastname: Landier
authors.forename: P
authors.initials: P
authors.lastname: Chatelain
authors.forename: J L
authors.initials: JL
authors.lastname: Chaussain
authors.forename: P F
authors.initials: PF
authors.lastname: Bougnères
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D002648:Child; D005240:Feasibility Studies; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy*; D013006:Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone