title: Citrate anticoagulation during in vivo simulation of slow hemofiltration.
abstract: Citrate anticoagulation has been used as an alternative to heparin for hemodialysis in high-risk patients; however, its use in hemofiltration has not been well studied. We examined citrate in 6 patients placed on slow hemofiltration for up to 6 h duration. During the experiments, the systemic citrate level increased from a baseline average of 0.15 to 0.55 mmol/l, and then decreased to 0.27 mmol/l. The citrate was freely filtered. The systemic total and ionized calcium decreased very slightly and no untoward effects were noted. Anticoagulation was successful. This preliminary study suggests that citrate anticoagulation can be used in slow hemofiltration.
authors.affiliation: Department of Medicine, University of Washington, Seattle.
authors.forename: S
authors.initials: S
authors.lastname: Ahmad
authors.forename: K T
authors.initials: KT
authors.lastname: Yeo
authors.forename: W M
authors.initials: WM
authors.lastname: Jensen
authors.forename: D
authors.initials: D
authors.lastname: Landicho
authors.forename: B
authors.initials: B
authors.lastname: Gregory
authors.forename: J L
authors.initials: JL
authors.lastname: Moritz
authors.forename: M
authors.initials: M
authors.lastname: Kenny
mesh_terms: D002118:Calcium / Q000097:blood; D002951:Citrates / Q000008:administration & dosage* / Q000494:pharmacology; D019343:Citric Acid; D005260:Female; D006440:Hemofiltration / Q000295:instrumentation; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D006435:Renal Dialysis
chemical_list: D002951:Citrates; D019343:Citric Acid; D002118:Calcium