title: Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.
abstract: The immunomodulatory activity of ginsenoside Rg1 from Panax ginseng was studied in mice using sheep red cells as the antigen. It was found that ginsenoside Rg1 at a dose of 10 mg/kg administered for three consecutive days before immunization increased the number of spleen plaque-forming cell, the titers of sera hemagglutinins as well as the number of antigen-reactive T-cells. Ginsenoside Rg1 also increased the number of T-helper cells with respect to the whole T-cell number and the splenocyte natural killer activity. Ginsenoside Rg1 induced an augmentation of the production of IL-1 by macrophages and exerted a direct mitogenic effect on microcultured thymus cells. Ginsenoside Rg1 also partly restored the impaired immune reactivity by cyclophosphamide treatment.
authors.affiliation: Department of Immunology, Bulgarian Academy of Science, Sofia.
authors.forename: B
authors.initials: B
authors.lastname: Kenarova
authors.forename: H
authors.initials: H
authors.lastname: Neychev
authors.forename: C
authors.initials: C
authors.lastname: Hadjiivanova
authors.forename: V D
authors.initials: VD
authors.lastname: Petkov
mesh_terms: D000818:Animals; D002452:Cell Count / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D036145:Ginsenosides; D006388:Hemagglutinins / Q000097:blood; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D012503:Saponins / Q000276:immunology* / Q000302:isolation & purification; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D036145:Ginsenosides; D006388:Hemagglutinins; D012503:Saponins; C035054:ginsenoside Rg1