Behavioral toxicity of anticholinesterases in primates: chronic pyridostigmine and soman interactions.
Dose rates for continuous infusion of pyridostigmine bromide required to inhibit 30% and 60% of normal serum cholinesterase activity in rhesus monkeys were determined. The effects of continuous pyridostigmine infusion at these dose-rates on the behavioral toxicity of 5 daily repeated low-dose exposures to a toxic organophosphate (soman) were determined not be deleterious; in fact, they were slightly (and variably) protective. Relative to controls (5-day soman ED50 = 0.89 micrograms/kg/day), pyridostigmine infusions producing 30% and 60% inhibition produced 5-day ED50s of 1.25 and 1.11 micrograms/kg/day, respectively. Variability in response to the pyridostigmine-soman combinations appeared to be greater than in response to daily soman exposure without pyridostigmine infusion.
Blick
D W
DW
Systems Research Laboratories Division of Arvin/Calspan, Brooks AFB, TX.
Kerenyi
S Z
SZ
Miller
S
S
Murphy
M R
MR
Brown
G C
GC
Hartgraves
S L
SL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002802:Cholinesterases / Q000097:blood; D015918:Infusion Pumps, Implantable; D008253:Macaca mulatta; D008297:Male; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D012999:Soman / Q000037:antagonists & inhibitors*
D012999:Soman; D002802:Cholinesterases; D011729:Pyridostigmine Bromide