Effect of prostaglandin E2 on urea synthesis and hepatic hemodynamics in rat livers. An in vivo/in vitro study.
The study was carried out on 30 rats. PGE2 was found to inhibit both the ammonium uptake and urea formation by hepatocytes, i.e. PGE2 inhibited the ornithine cycle in a non-recirculating perfusion of the liver. Simultaneously PGE2 inhibited liver oxygen uptake and raised portal pressure. Inhibition of urea synthesis in the liver and decrease of hepatic hemodynamics by PGE2 were also found in experiments in vivo. The PGE2 inhibiting effect on urea synthesis may be achieved mainly through decreasing hepatic blood flow and perhaps, by hypoxia.
Mitkov
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Department of Pathophysiology, Higher Medical Institute I. P. Pavlov, Plovdiv, Bulgaria.
D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D015232:Dinoprostone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D008102:Liver Circulation; D009952:Ornithine / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011169:Portal Vein / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000378:metabolism*
D000641:Ammonia; D014508:Urea; D009952:Ornithine; D015232:Dinoprostone; D010100:Oxygen