title: [The relationship between the chemical structure and the antiarrhythmic action of ethacizine and its analogs].
abstract: The relationship between the chemical structure and the antiarrhythmic activity of phenothiazine derivatives--ethacizine and its analogues--was estimated quantitatively by the value of the antiarrhythmic effect on aconitine model in conscious rats. The lengthening of the side chain of nitrogen atom in position 10 of phenothiazine cycle by one methylene group as well as the substitution of demethylamine radical for diethylamine one increased the antiarrhythmic activity; the toxicity of the compound being also increased. Ethacizine was found to possess the highest antiarrhythmic activity and the greatest antiarrhythmic index.
authors.forename: A I
authors.initials: AI
authors.lastname: Turilova
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Berdiaev
authors.forename: A N
authors.initials: AN
authors.lastname: Grishchenko
authors.forename: Z P
authors.initials: ZP
authors.lastname: Senova
mesh_terms: D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D010640:Phenothiazines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C046818:ethacizine; D000157:Aconitine
vernacular_title: Sviaz' mezhdu khimicheskoĭ strukturoĭ i antiaritmicheskim deĭstviem étatsizina i ego analov.