Heparin by alternative routes of administration.
In a study investigating the bioavailability of heparin administered by different routes, we also compared its bioavailability in the dog after oral administration of two enteric-coated formulations, one containing a heparin preparation (ITF-300) and the other sodium heparin. After administration of the formulation containing sodium heparin, there was no heparin in plasma, but when the formulation containing ITF-300 was given, plasma heparin levels were detectable.
Andriuoli
G
G
Department of Pharmacology, Italfarmaco Research Center, Milan, Italy.
Bossi
M
M
Caramazza
I
I
Zoppetti
G
G
D000284:Administration, Oral; D000818:Animals; D001681:Biological Assay; D004285:Dogs; D006493:Heparin / Q000008:administration & dosage*; D008297:Male; D013608:Tablets, Enteric-Coated
D013608:Tablets, Enteric-Coated; D006493:Heparin