[Effect of allopurinol on the indicators of immunity in podagra and experimental hyperuricemia].
The authors studied the immunity indices in patients with gout against the background of a long-term (one year) therapy with allopurinol, and in animals with experimental hyperuricemia. During treatment the authors observed normalization of blood immunoglobulin M level, a considerable decrease in circulating immune complexes and anti-renal antibodies, a tendency to a rise in the function of T-lymphocytes, great enhancement of the activity of polymorphonuclear phagocytes in tests with Staphylococci and nitro-blue tetrazolium. Mechanisms of action of the given drug are discussed.
Siniachenko
O V
OV
Nikolenko
Iu I
IuI
Diadyk
A I
AI
Bortnik
V A
VA
Okushko
R V
RV
D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006073:Gout / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D051381:Rats; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000097:blood*
D014527:Uric Acid; D000493:Allopurinol
Vliianie allopurinola na pokazateli immuniteta pri podagre i éksperimental'noĭ giperurikemii.