N3-arylspiroimidazolidine-2,4-diones N3-arylspiroimidazolidine-2-thio-4-ones and 4-hydroxy derivatives. Synthesis and anthelmintic activity.
The synthesis of new N3-arylciclohexanespiroimidazolidine-2,4-diones, N3-arylciclohexanespiroimidazolidine-2-tio-4-ones and the 4-hydroxy derivatives is described and their structures discussed on the basis of I.R. and 1H-N.R.M. data. The anthelmintic activity of these compounds was tested.
Espada
M
M
Dpto. de Quimica Orgánica y Farmacéuticia, Facultad de Farmacia, Universidad Complutense, Madrid, España.
Pedregal
C
C
Alonso
A
A
López
C
C
Salazar
L
L
Martinez
M M
MM
Guillén
J L
JL
Martinez
A R
AR
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D004757:Enterobius / Q000187:drug effects; D006369:Heligmosomatoidea / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010124:Oxyuroidea / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
D000871:Anthelmintics; D007093:Imidazoles; D013141:Spiro Compounds; D013871:Thiones