title: [Altered composition of gangliosides in the erythrocyte membrane and in the plasma of alcoholic patients].
abstract: Gangliosides were isolated from plasma and membranes of erythrocytes of alcoholics. The pattern of gangliosides were compared with the data of healthy donors. Up to 7 fractions of gangliosides could been detected after extraction, purification by column chromatography and fractionation by TLC. In alcoholics the main ganglioside fractions of plasma GM3 were increased (52.6%) and GD3 were decreased (17.5%). The GM3 and GD1b fraction of erythrocytes membranes were decreased significantly in alcoholics.
authors.affiliation: Institut für Pathologische Biochemie, Medizinischen Akademie Magdeburg.
authors.forename: V S
authors.initials: VS
authors.lastname: Westphal
authors.forename: U
authors.initials: U
authors.lastname: Haselhorst
authors.forename: V
authors.initials: V
authors.lastname: Kielstein
authors.forename: H
authors.initials: H
authors.lastname: Schenk
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood*; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005732:Gangliosides / Q000097:blood*; D006801:Humans
chemical_list: D005732:Gangliosides
vernacular_title: Veränderte Zusammensetzung für Ganglioside in den Membranen der Erythrozyten und im Plasma alkoholabhängiger Kranker.