[Effects of perilymphatic perfusion with cisplatin on the cochlear potential in guinea pigs].
The effects of three concentrations of cisplatin, administered by acute perilymphatic perfusion on the endocochlear potential (EP) and the cochlear microphonic potential (CM) of the guinea pig cochleae, at 1 kHz are reported. No change in EP magnitude was discovered and a concentration-dependent reduction in CM amplitude occurred during 60 minutes' perfusion period. The results suggest that cisplatin-induced hearing loss is not necessarily progressive degradation of EP.
Wu
D Z
DZ
Shuguang Hospital, Shanghai College of Traditional Chinese Medicine.
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects*; D003052:Cochlear Aqueduct / Q000187:drug effects; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006312:Hearing Loss, Bilateral / Q000139:chemically induced
D002945:Cisplatin