title: Genetic variation, hippocampal mossy fibres distribution, novelty reactions and spatial representation in mice.
abstract: It is now well established that variation in hippocampal circuitry correlates with various behavioural measures. In order to formulate more precise hypotheses about the functional role of the supra (SP-MF) and intra-infra mossy fibres (IIP-MF) layers, we investigated their covariation with a large number of behavioural measures in the classic and the spatial open-field taken from a genetically heterogeneous population composed of subjects from 12 isogenic mice groups (9 inbred strains and 3 F1's). The hippocampus-behaviour intercorrelation matrix reveals that behavioural reactions and inferred psychological processes only correlate with IIP-MF. Detailed analysis of correlates shows that IIP-MF positively correlate with locomotor activity, rearings and central sector crossings in the classic open-field and correlate negatively with the short-term habituation index to the objects in the spatial open-field. Surprisingly the memory of the spatial arrangement of a set of objects does not correlate with any hippocampal measure.
authors.affiliation: Laboratoire d'Ethologie et de Psychophysiologie, UFR Sciences et Techniques, Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: Roullet
authors.forename: J M
authors.initials: JM
authors.lastname: Lassalle
mesh_terms: D000818:Animals; D001143:Arousal / Q000235:genetics* / Q000502:physiology; D001931:Brain Mapping; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006185:Habituation, Psychophysiologic / Q000235:genetics / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000235:genetics* / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology*; D012931:Social Environment; D013569:Synapses / Q000502:physiology