title: [Effect of structure of hapten carrying model substances on contact reaction: DNP conjugates of stereoisomers of alpha-alanine following DNCB sensitization].
abstract: By means of epicutaneous tests under standard conditions we studied the cell-mediated contact sensitivity to dinitrophenyl (DNP) conjugates of the stereoisomeric amino acids L-alpha-alanine and D-alpha-alanine, respectively, in patients sensitized with dinitrochlorobenzene (DNCB). There was no difference in the number of positive skin responses with the two enantiomeric compounds DNP-L-alpha-alanine (16/26) and DNP-D-alpha-alanine (17/26). However, as in earlier studies, no patient has shown a positive reaction to the position-isomeric DNP-beta-alanine.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Martin-Luther-Universität Halle, Wittenberg.
authors.forename: G
authors.initials: G
authors.lastname: Schwartze
authors.forename: D
authors.initials: D
authors.lastname: Lübbe
mesh_terms: D000409:Alanine / Q000276:immunology*; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology*; D004137:Dinitrochlorobenzene; D005260:Female; D006241:Haptens / Q000276:immunology*; D006801:Humans; D008297:Male; D010328:Patch Tests; D013329:Structure-Activity Relationship
chemical_list: D004136:Dinitrobenzenes; D004137:Dinitrochlorobenzene; D006241:Haptens; D000409:Alanine
vernacular_title: Der Einfluss der Struktur haptentragender Modellsubstanzen auf die Kontaktreaktion: DNP-Konjugate der Stereoisomeren des alpha-Alanins nach DNCB-Sensibilisierung.