[Tuberculosis sequelae: secondary fungal infections].
The antibody activities against Aspergillus fumigatus, Cryptococcus neoformans and Coccidioides immmitis by complement fixation (CF) were examined for active and cured pulmonary tuberculosis in 1985, and against Aspergillus fumigatus and Candida albicans by indirect hemagglutination (IHA) and counterimmunoelectrophoresis (CIE) in 1986. The antibody activity against Aspergillus by CF was positive in 8.6% of the sera and negative against Cryptococcus, and Coccidioides. The IHA results were positive in 2.9% against Aspergillus and in 44.9% against Candida. The CIE results were positive in 19.5% against Aspergillus and in 16.3% against Candida. Based on chest X-ray films, the development of pulmonary candidiasis was non-specific but that of pulmonary aspergilloma in tuberculous cavities was specific. Before aspergillomas were formed, the tuberculous cavities had become thin-walled. Then the cavities increased or decreased in size. It is postulated that the cavity has tension when check-valved by mycetome in the drainage bronchus, and becomes smaller or distinct when ventilated inadequately. In cases cavities do not change in size due to intracavitary proliferation of Aspergillus, the wall of cavity is rough, prominent, or opaque.
Iwata
H
H
Department of Microbiology, Fukui Medical School, Japan.
Miwa
T
T
Takagi
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001228:Aspergillosis / Q000209:etiology*; D002177:Candidiasis / Q000209:etiology*; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications*