Alloantibody anti-Gerbich: blood transfusion problems and family studies.
In a patient with myelodysplastic syndrom complement fixing IgG1 anti-Ge three weeks after Ge positive serologically compatible blood transfusion was found. The patient and one of his children were Ge-1, -2, -3. Red cells were elliptocytic. The patient's nonconsanguineous wife and other family members were Ge positive. In the red cell membranes of Ge negative persons glycophorin C was lacking. Abnormal glycophorin was present in the red cell membranes of all family members. Anti-Ge appeared to be of no clinical significance. Transfusion of serologically incompatible Ge positive blood provided beneficial effect. After this transfusion anti-Ge disappeared from the serum and was not detected at the whole follow-up, although the patient received Ge positive blood several times. Immunological tolerance towards Ge antigen is suggested.
Kuśnierz-Alejska
G
G
Department of Serology, Institute of Haematology, Warszawa, Poland.
Seyfried
H
H
Jaśkiewicz
E
E
Janczarski
M
M
D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology*; D001803:Blood Transfusion; D005192:Family Health; D006801:Humans; D007518:Isoantibodies / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001789:Blood Group Antigens; D007518:Isoantibodies