title: An in vivo study of neutrophil locomotion in relation to periodontal disease status and local chlorhexidine.
abstract: Neutrophil migration from skin window abrasions was studied in 10 patients with no history of periodontitis, 10 with localised juvenile or post-juvenile periodontitis, and 10 with chronic adult periodontitis. Filters contained either saline or chlorhexidine (0.002% or 0.02%). The leading front was measured in filters placed for 30 min after cell migration had been established for 2 h. Subjects in the juvenile/post juvenile group showed a reduced range of migration distances, but were still within the normal range when compared with the other 2 groups. Chlorhexidine at 0.002% tended to increase leading front distances, and 0.02% to decrease them. We conclude that: 1) migrating neutrophils in vivo may move less far in patients with a history of juvenile periodontitis; 2) chlorhexidine may inhibit cell migration, possibly decreasing the host response in vivo if applied at current therapeutic concentrations.
authors.affiliation: United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England.
authors.forename: K G
authors.initials: KG
authors.lastname: Seymour
authors.forename: T L
authors.initials: TL
authors.lastname: Watts
authors.forename: I E
authors.initials: IE
authors.lastname: Addison
authors.forename: B
authors.initials: B
authors.lastname: Johnson
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000276:immunology*; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D012884:Skin Window Technique
chemical_list: D002710:Chlorhexidine