Cross resistance between oxytetracycline and oxolinic acid in Aeromonas salmonicida associated with alterations in outer membrane proteins.
Oxytetracycline resistant mutants of Aeromonas salmonicida isolated from mutation frequency experiments showed decreased susceptibility to oxolinic acid. Outer membrane preparations of these resistant mutant strains revealed a major protein, with a molecular mass of approximately 37 kDa, which was not present in significant quantities in the parent strain.
Barnes
A C
AC
Department of Bacteriology, University of Edinburgh, Medical School, U.K.
Lewin
C S
CS
Hastings
T S
TS
Amyes
S G
SG
D000333:Aeromonas / Q000187:drug effects* / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010093:Oxolinic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000235:genetics
D001425:Bacterial Outer Membrane Proteins; D010093:Oxolinic Acid; D010118:Oxytetracycline