[Synthesis of ganoderma alkaloid A and B].
Ganoderma alkaloid A (IA, 1-isopentyl-2-formyl-5-hydroxymethylpyrrole) and B (IB, 1-phenylethyl-2-formyl-5-hydroxymethylpyrrole) were discovered in the hypha of deep fermented Ganoderma capense. Both are new pyrrole alkaloids. In order to provide samples for bioassay, we completed the synthesis of these new alkaloids and their acetyl derivatives. The route of synthesis included six steps. The whole yields were 20.7% for IA and 24.7% for IB. Synthetic IA and IB were found to be identical with the natural compounds by comparison of spectral data. IA and IB showed some antiinflammatory activity in animal experiments.
Yang
J J
JJ
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Yu
D Q
DQ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000302:isolation & purification; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D011124:Polyporaceae / Q000032:analysis; D011758:Pyrroles / Q000138:chemical synthesis* / Q000302:isolation & purification
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; C067951:ganoine; C067952:ganodine