[Preparation of monodesethylamodiaquine from human urine].
60 mg of monodesethylamodiaquine, the active metabolite of amodiaquine were prepared by extraction from human urine, at pH 11-12, using ethyl acetate. The purification was carried out by medium pressure liquid chromatography. The identity and the purity of the compound were checked by thin layer chromatography, 1H nuclear magnetic resonance and mass spectrometry.
Ménager
S
S
Groupe de Pharmacochimie, Faculté de Médecine, Saint-Etienne-du-Rouvray.
Lafont
O
O
Chrétien
P
P
Bryskier
A
A
D000655:Amodiaquine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000652:urine; D000962:Antimalarials / Q000302:isolation & purification / Q000652:urine*; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D000962:Antimalarials; D000655:Amodiaquine; C047386:desethylamodiaquine
Préparation de monodéséthylamodiaquine à partir d'urines humaines.