Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.
E6123 inhibited antigen-induced bronchoconstriction, the development of bronchial hyperreactivity and eosinophil infiltration in the airway in passively sensitized guinea pigs and protected mice from anaphylactic death. The inhibitory effects of E6123 on anaphylactic response were very potent compared with those of WEB 2347 and Y-24180.
Sakuma
Y
Y
Tsukuba Research Lab., Eisai Co., Ltd., Ibaraki, Japan.
Tsunoda
H
H
Katayama
S
S
Harada
K
K
Obaishi
H
H
Shirato
M
M
Yamada
K
K
Miyazawa
S
S
Okano
K
K
Machida
Y
Y
D000707:Anaphylaxis / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D001381:Azepines / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology*
D000941:Antigens; D001381:Azepines; D010972:Platelet Activating Factor; D014230:Triazoles; C068033:E 6123