title: Intratympanic gentamycin in severe Ménière's disease.
abstract: From 1982 to 1987, 20 patients with disabling attacks of vertigo and severe hearing loss due to unilateral Ménière's disease were treated with local intratympanic gentamycin. In 18 patients control of vertiginous attacks was achieved. Hearing deteriorated in 8 patients. In spite of complete control of attacks a disabling ablation type of unsteadiness and dizziness affected 7 patients. Two patients required additional treatment after 5-8 months remission. Intratympanic gentamycin seems to be a less useful method of treating severe unilateral Ménière's disease than previously stated. It is, however, a possible alternative to surgical labyrinthectomy with a fair chance of residual hearing preservation.
authors.affiliation: Department of Otolaryngology, University of Oulu, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Laitakari
mesh_terms: D004432:Ear, Middle; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D008876:Middle Ear Ventilation
chemical_list: D005839:Gentamicins