Lipids and thrombosis.
There is extensive evidence of important interactions between plasma lipoproteins and platelet function. Some population groups, particularly hypercholesterolaemic patients, have strong evidence of abnormal platelet function which is mediated by the binding of lipoproteins, especially oxidized LDL, to surface receptors. Additionally, abnormal plasma lipid levels precipitate membrane composition changes by increasing the cholesterol:phospholipid ratio. The resulting changes in microviscosity seem to affect transmembrane signalling and might in some cases influence receptor binding. This not only has important therapeutic implications with regard to lipid-lowering drug therapy but also with regard to the potential beneficial effects of dietary therapy.
Gasser
J A
JA
Betteridge
D J
DJ
D001792:Blood Platelets / Q000502:physiology; D004041:Dietary Fats / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D013927:Thrombosis / Q000178:diet therapy / Q000209:etiology*
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D008077:Lipoproteins, LDL