Effect of neuropeptide Y on jejunal water and ion transport in humans.
Neuropeptide Y is a neurotransmitter in enteric and postganglionic sympathetic neurons. In animal models of intestinal water and ion transport, neuropeptide Y decreases stimulated secretion but has no consistent effect on basal transport. In the present study, the effect of neuropeptide Y on jejunal water and electrolyte transport in healthy volunteers was investigated under basal conditions and during intestinal secretion induced by intraluminal administration of prostaglandin E2. The triple-lumen tube technique was used for perfusion of the small intestine with a plasmalike electrolyte solution containing polyethylene glycol as a nonabsorbable volume marker. After an initial control period (saline IV) neuropeptide Y was administered IV at a dose of 400 pmol.kg-1.h-1. Neuropeptide Y significantly increased net absorption of water, sodium, potassium, and chloride under basal conditions. The peptide significantly reduced the secretion of these electrolytes induced by an intraluminal prostaglandin E2 concentration of 5 mumol/L and reduced net water secretion by 36%. The results of the current study suggest that neuropeptide Y can change intestinal water and ion transport from secretion toward absorption.
Holzer-Petsche
U
U
Department of Internal Medicine, Karl Franzens University, Graz, Austria.
Petritsch
W
W
Hinterleitner
T
T
Eherer
A
A
Sperk
G
G
Krejs
G J
GJ
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000097:blood / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D001639:Bicarbonates; D002712:Chlorides; D009478:Neuropeptide Y; D014867:Water; D012964:Sodium; D015232:Dinoprostone; D011188:Potassium