title: Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone.
abstract: In this review, the properties, pharmaceutical profile, and metabolism of Azone are described, and the mechanism of its action in facilitating transdermal drug delivery is discussed. It is concluded that the compound is safe for human use, and of value in enhancing the cutaneous absorption of many types of drugs.
authors.affiliation: Gronigen Centre for Drug Research, University of Groningen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Wiechers
authors.forename: R A
authors.initials: RA
authors.lastname: de Zeeuw
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D005079:Excipients; D006801:Humans
chemical_list: D001381:Azepines; D005079:Excipients; C035229:laurocapram