Pharmacokinetics of eltoprazine in healthy subjects.
The pharmacokinetics of eltoprazine in healthy male subjects was investigated after intravenous and oral dosing in one study, and after oral dosing of 14C-eltoprazine in a second study. It was shown that the absorption of eltoprazine from the gastro-intestinal tract was complete, and that absolute bioavailability was 100%. The mean elimination half-life of eltoprazine in plasma was about 8 hours. Approximately 40% of the dose was excreted unchanged in urine.
van Harten
J
J
Duphar B.V., Drug Disposition Department, Weesp, The Netherlands.
Mathlener
I S
IS
Raghoebar
M
M
D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D010879:Piperazines; C063828:eltoprazine