Histamine: a neurotransmitter that influences food intake?
Brain histamine levels in rats in various states of water balance were raised by blocking histamine catabolism with metoprine. Acute administration of this drug caused a significant reduction in food intake. This finding suggests a possible role of histamine in the regulation of food intake.
D000818:Animals; D001921:Brain / Q000187:drug effects; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005493:Folic Acid Antagonists / Q000494:pharmacology; D006632:Histamine / Q000502:physiology*; D008297:Male; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005493:Folic Acid Antagonists; C006308:metoprine; D006632:Histamine; D011739:Pyrimethamine