Heat conductivity and skin temperature at the treatment of ischemic heart disease with curantyl and isoptin.
Forty one patients with ischaemic heart disease (IHD) of the age 60 +/- 12.3 years were hospitalized and treated two weeks with Curantyl (Dipyridamol) which was applied per os in a dose of 75 mg 3 times, and after another two weeks 34 of them wass applied Isoptin (Verapamil) in a dose of 40 mg 3 times daily. The heat conductivity (J.m-1, sec-1.degree C.10(-2), HC) and skin temperature (degree C, ST) were examined at the isothermic level 2 cm above the inner ankle by the apparatus Fluvograph 2 of Hartmann and Braun A. G. (BRD). The HC after Isoptin application above the left and right ankle was in 34 patients increased significantly (p less than 0.001). In patients with IHD after Curantyl application the HC and ST was significantly decreased above the left and right ankle in 9 (21.9%) and in 12 (30.0%), respectively. Curantyl could deteriorate HC and so to worsen legs ulceration healing and to point ap ischemia in patients with associated chronic postphlebitic syndrome with ulcera crurium.
Kollár
J
J
Institute of Experimental Medicine, University P. J. Safarik, Kosice, Czechoslovakia.
Uhrík
J
J
Hejj
F
F
D001833:Body Temperature Regulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004176:Dipyridamole / Q000627:therapeutic use*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D011186:Postphlebitic Syndrome / Q000503:physiopathology; D012881:Skin Temperature / Q000187:drug effects*; D014700:Verapamil / Q000627:therapeutic use*
D004176:Dipyridamole; D014700:Verapamil