title: Synergistic effect of promethazine with gentamycin in frequently recurring pyelonephritis.
abstract: The effects of promethazine were studied in children with frequently recurring pyelonephritis which was not associated with urological abnormalities. The results of three methods of treatment were compared: 10 children were given a combination of gentamycin and promethazine for 7 days (Group 1), 11 received gentamycin treatment alone for 10 days (Group 2), and 19 (Group 3) were on long-term oral antibiotic prophylaxis (5.6 +/- 2.1 years) with episodes of intensive treatment of recurrences. In a 3-year follow-up period, the number of pyelonephritis recurrences was significantly lower in Group 1 than in Groups 2 and 3. Six out of 19 children in Group 3 had renal scarring. The authors suggest a synergistic effect between gentamycin and promethazine therapy. Promethazine increases antibiotic sensitivity, which could contribute to the elimination of recurring urinary tract infections.
authors.affiliation: Department of Microbiology, Szent-Györgyi Albert University Medical School, Szeged, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Molnár
authors.forename: I
authors.initials: I
authors.lastname: Haszon
authors.forename: T
authors.initials: T
authors.lastname: Bodrogi
authors.forename: E
authors.initials: E
authors.lastname: Martonyi
authors.forename: S
authors.initials: S
authors.lastname: Turi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011398:Promethazine / Q000627:therapeutic use*; D011704:Pyelonephritis / Q000175:diagnosis / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D005839:Gentamicins; D011398:Promethazine