Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw.
Casearins G-R, new cytotoxic clerodane diterpenes have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). Their structures have been elucidated by spectroscopic methods and chemical conversions, and their structure-activity relationships have been discussed.
Morita
H
H
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Nakayama
M
M
Kojima
H
H
Takeya
K
K
Itokawa
H
H
Schenkel
E P
EP
Motidome
M
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes