title: N-acetylation and debrisoquine type oxidation polymorphism in Caucasians--with reference to age and sex.
abstract: Phenotypes of the N-acetylation and debrisoquine type oxidation polymorphism were determined with sulfamethazine and debrisoquine in 145 healthy volunteers (31-80 years, 64 males, 81 females) of a North-East German area. Seventeen (11.7%) were poor metabolizers of debrisoquine and 81 (55.9%) slow acetylators of sulfamethazine. No significant correlations between the frequencies of oxidation and acetylation phenotypes, age, and sex were found. Only a tendency of rapid acetylators to accumulate among individuals above 60 years was noticed. Parameters of phenotyping were not influenced by sex. With age, metabolic ratios of N-acetylation but not of oxidation phenotyping increased. The urinary excretion (0-8 hours) of debrisoquine, sulfamethazine and their metabolites was strikingly reduced in the elderly. Misclassifications of acetylation phenotyping cannot be excluded because of the age dependent kinetics of the test drug.
authors.affiliation: Department of Clinical Pharmacology, University of Greifswald, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Siegmund
authors.forename: W
authors.initials: W
authors.lastname: Hanke
authors.forename: M
authors.initials: M
authors.lastname: Zschiesche
authors.forename: G
authors.initials: G
authors.lastname: Franke
authors.forename: K E
authors.initials: KE
authors.lastname: Biebler
authors.forename: A
authors.initials: A
authors.lastname: Wilke
mesh_terms: D000107:Acetylation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic / Q000502:physiology*; D012727:Sex Characteristics; D044465:White People / Q000235:genetics*
chemical_list: D003647:Debrisoquin