Cytotoxicity on L1210 leukemic cells of beta-amanitin-concanavalin A and phallacidin-concanavalin A conjugates.
The conjugates beta-amanitin-concanavalin A and phallacidin concanavalin A were tested for direct cytotoxicity on L1210 lymphocytic leukemia cells by a combined in vitro-in vivo bioassay. Both conjugates exerted strong direct cytotoxicity on the tumour cells.
Zhelev
Z
Z
University School of Medicine, Department of Biology, Stara Zagora, Bulgaria.
Ilarionova
M
M
Zheleva
A
A
Alexiev
C
C
Halacheva
K
K
Todorov
D
D
D000546:Amanitins / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival; D003208:Concanavalin A; D003603:Cytotoxins / Q000633:toxicity*; D000922:Immunotoxins; D007939:Leukemia L1210; D010456:Peptides, Cyclic / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D000546:Amanitins; D003603:Cytotoxins; D000922:Immunotoxins; D010456:Peptides, Cyclic; D003208:Concanavalin A; C049197:beta-amanitin; C017613:phallacidin