Primaquine-induced oxidative stress in isolated hepatocytes as a result of reductive activation.
Silva
J M
JM
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
O'Brien
P J
PJ
D000818:Animals; D001711:Biotransformation; D002470:Cell Survival / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D011319:Primaquine / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D006861:Hydrogen Peroxide; D005978:Glutathione; D011319:Primaquine