Helium microwave-induced plasma mass spectrometric detection for reversed-phase high-performance liquid chromatography.
Reversed-phase high-performance liquid chromatography (HPLC) is directly coupled to helium microwave-induced plasma mass spectrometry (He MIP-MS) for the element-selective detection of halogenated organic compounds. Absolute detection limits are approximately 50 pg Br for brominated compounds, 1 pg I for iodinated compounds, and 10 ng Cl for chlorinated compounds. The linear dynamic range for Br- and I-containing compounds is 3-4 orders of magnitude. However, the linear range for chlorinated species is severely limited by high background at m/z = 35. The relative standard deviation for repetitive injections is less than 10%. The helium microwave-induced plasma is operated at moderate powers (300-350 W) and with a total helium consumption of 6-8 L/min. The effect of organic solvents on the background mass spectrum is investigated.
Heitkemper
D
D
Department of Chemistry, University of Cincinnati, OH 45221.
Creed
J
J
Caruso
J A
JA
D001965:Bromides / Q000032:analysis; D002712:Chlorides / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006371:Helium; D007455:Iodine / Q000032:analysis; D013058:Mass Spectrometry / Q000379:methods*; D008872:Microwaves
D001965:Bromides; D002712:Chlorides; D006371:Helium; D007455:Iodine