Barrel rotation in rats induced by SMS 201-995: suppression by ceruletide.
Intracerebroventricular administration of SMS 201-995 (5 micrograms/rat), a somatostatin analogue, induced barrel rotation in rats. Pretreatment with ceruletide (40 micrograms/100 g b. wt., IP) 3 days or 7 days prior to the injection of SMS 201-995 significantly inhibited the response rate of barrel rotation induced by SMS 201-995, but not that induced by arginine-vasopressin (1 microgram/rat, ICV). The suppressive effect of ceruletide on barrel rotation could be partially countered by MK-329, a selective peripheral CCK (CCK-A) receptor antagonist. Desulfated cerulein did not affect the barrel rotation induced by SMS 201-995. These findings suggest that ceruletide specifically suppresses the barrel rotation evoked by SMS 201-995 in a long-lasting manner possibly acting through CCK-A receptor.
Ishikawa
Y
Y
Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
Shimatsu
A
A
Murakami
Y
Y
Imura
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D020109:Devazepide; D007276:Injections, Intraventricular; D008297:Male; D008969:Molecular Sequence Data; D015282:Octreotide / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D001570:Benzodiazepinones; D010277:Parasympathomimetics; D001127:Arginine Vasopressin; D002108:Ceruletide; D002766:Cholecystokinin; D020109:Devazepide; D015282:Octreotide