Corticosteroid- and furosemide-induced increase in proteinuria in nephrosis.
A corticosteroid- and furosemide-induced excessive increase in proteinuria developed in a 34-year-old nephrotic patient with focal glomerulosclerosis. The concentration of urinary protein increased almost in parallel with that of urinary glucose. This finding indicates that corticosteroids and/or furosemide can promote the disturbance of the tubular reabsorption mechanism together with increases in glomerular permeability and glomerular filtration rate.
Inoue
T
T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Okamura
M
M
Negoro
N
N
Fujisawa
M
M
Inariba
H
H
Takeda
T
T
Kanayama
Y
Y
D000328:Adult; D005665:Furosemide / Q000009:adverse effects*; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects*; D009401:Nephrosis / Q000150:complications*; D011507:Proteinuria / Q000139:chemically induced* / Q000209:etiology
D005665:Furosemide; D008775:Methylprednisolone