Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
The present study was carried out to test the effects of L-alpha-glycerylphosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in man. Thirty-two healthy young volunteers were randomly allocated to four different groups. They were given a ten day pretreatment with either L-alpha-GFC or placebo, p.o., and on the eleventh day either scopolamine or placebo, i.m. Before and 0.5, 1, 2, 3, and 6 h after injection the subjects were given attention and mnemonic tests. The findings of this study indicate that the drug is able to antagonize impairment of attention and memory induced by scopolamine.
Canal
N
N
Department of Neurology, S. Raffaele Institute, University of Milan, Italy.
Franceschi
M
M
Alberoni
M
M
Castiglioni
C
C
De Moliner
P
P
Longoni
A
A
D000328:Adult; D000647:Amnesia / Q000139:chemically induced / Q000517:prevention & control*; D001288:Attention / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D011292:Premedication; D012601:Scopolamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D005997:Glycerylphosphorylcholine; D012601:Scopolamine