title: Haemodynamics of leg veins during a 30-days-6 degrees head-down bedrest with and without lower body negative pressure.
abstract: Venous distensibility of the lower limbs was assessed in six healthy men who were submitted twice successively to 1 month of -6 degrees head-down bedrest, with and without lower body negative pressure (LBNP) (LBNP subjects and control subjects, respectively). Venous capacity (delta Vv,max, in ml.100 ml-1) of the legs was determined by mercury strain gauge plethysmography with venous occlusion. Plethysmographic measurements were made on each subject before (Dc), during (D6 and D20) and after (5th day of recovery, D+5) bedrest. During bedrest, LBNP was applied daily, several times a day to the subjects submitted to this procedure. Results showed a gradual increase in Vv,max (ml.100 ml-1) throughout the bedrest, both in the control group [delta Vv,max = 2.11 SD 0.54 at Dc, 2.69 SD 0.29 at D6, 4.39 SD 2.08 at D20, 2.39 SD 0.69 at D+5, P less than 0.001 (ANOVA)] and in the LBNP group [delta Vv,max = 2.07 SD 0.71 at Dc, 2.85 SD 1.19 at D6, 3.75 SD 1.74 at D20, 2.43 SD 0.94 at D+5, P less than 0.001 (ANOVA)], without significant LBNP effect. These increases were of the same order as those encountered during spaceflight. It is concluded that -6 degrees head-down bedrest is a good model to simulate the haemodynamic changes induced by exposure to weightlessness and that LBNP did not seem to be a good technique to counteract the adverse effects of weightlessness on the capacitance vessels of the lower limbs. This latter conclusion raises the question of the role and magnitude of leg venous capacitance in venous return and cardiac regulation.
authors.affiliation: C.E.R.M.A. = Centre d'Etudes et de Recherches de Médecine Aérospatiale, Brétigny-sur-Orge, France.
authors.forename: F
authors.initials: F
authors.lastname: Louisy
authors.forename: C
authors.initials: C
authors.lastname: Gaudin
authors.forename: J M
authors.initials: JM
authors.lastname: Oppert
authors.forename: A
authors.initials: A
authors.lastname: Güell
authors.forename: C Y
authors.initials: CY
authors.lastname: Guezennec
mesh_terms: D000328:Adult; D001510:Bed Rest / Q000379:methods; D006112:Gravitation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000502:physiology; D008297:Male; D010991:Plethysmography; D013997:Time Factors; D014680:Veins / Q000502:physiology; D014893:Weightlessness