title: [Safety of donors, quality of products, how much to reduce the quantity of citrate].
abstract: We examined 1,053 blood samples from 48 donors, for the effect of gradual reduction of citrate. We observed that: 1--Platelet count does not show any significant variation between 1/8 to 1/18 ratio. 2--In 13.3% of the cases, platelet clumping starts at 1/18 ratio. 3--There was no significant variation of the thrombin plasma level between 1/8 to 1/16 ratio (by measuring thrombin/ATIII complex). Our results show clearly that we can reduce the citrate ratio to 1/14 without expecting any adverse effect. Therefore we designated 1/14 as the security ratio. Parallel to this we also found that the average level +/- SD of ionized calcium is 100 +/- 10 muMol at 1/14 ratio.
authors.affiliation: C.T.S. Hôpital Paul Brousse, Villejuif.
authors.forename: P
authors.initials: P
authors.lastname: Farrokhi
authors.forename: S
authors.initials: S
authors.lastname: Marion
authors.forename: M
authors.initials: M
authors.lastname: Samama
authors.forename: M C
authors.initials: MC
authors.lastname: Gillon
authors.forename: C
authors.initials: C
authors.lastname: Suarez
authors.forename: A
authors.initials: A
authors.lastname: Bismuth
authors.forename: H
authors.initials: H
authors.lastname: Farahmand
authors.forename: P
authors.initials: P
authors.lastname: Debat
authors.forename: T
authors.initials: T
authors.lastname: Beugre
authors.forename: K
authors.initials: K
authors.lastname: Madani
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001782:Blood Donors; D001803:Blood Transfusion / Q000379:methods*; D002118:Calcium / Q000097:blood; D002951:Citrates; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism; D010976:Platelet Count
chemical_list: D002951:Citrates; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D002118:Calcium
vernacular_title: Sécurité des donneurs, qualité des produits jusqu'où diminuer la quantité de citrate.