Potentiation of antitumor activity of pirarubicin by chlorpromazine in mice bearing doxorubicin-resistant P388 leukemia.
Chlorpromazine enhanced the cytotoxicity of pirarubicin against doxorubicin-resistant P388 leukemia cells in colony forming assays. Chlorpromazine also prolonged the survival of mice bearing doxorubicin-resistant P388 leukemia, when given in combination with pirarubicin.
Shibata
H
H
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Maekawa
I
I
Furusawa
S
S
Kawauchi
H
H
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002746:Chlorpromazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice
D004317:Doxorubicin; C027260:pirarubicin; D002746:Chlorpromazine