Free radical scavenging: a potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors.
Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10(-5) M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.
Chopra
M
M
Department of Chemistry, Strathclyde University, U.K.
McMurray
J
J
Stewart
J
J
Dargie
H J
HJ
Smith
W E
WE
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D002216:Captopril / Q000031:analogs & derivatives / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers; D006801:Humans; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy
D000806:Angiotensin-Converting Enzyme Inhibitors; D016166:Free Radical Scavengers; C044958:zofenopril; D002216:Captopril