Evaluation of glucose transport in malignant glioma by PET.
Using dynamic PET mode and 18FDG, glucose transport in patients with gliomas were investigated. The values for transfer rate constants k1*, k2*, k3*, and glucose consumption were found to be low in the low-grade glioma as compared to those of the high-grade glioma and the contralateral cerebral cortex. The differences were statistically significant with the exception of k2*. There were no statistically significant differences between the high-grade glioma and the contralateral cerebral cortex. In contrast, the distribution volumes k1*/k2* and k1*/(k2* + k3*) were low in high-grade glioma and the difference between the high-grade glioma and the contralateral cerebral cortex was statistically significant. A difference in k1*/(k2* + k3*) was noted between the low-grade and the high-grade gliomas. Thus, the distribution volumes are most sensitive for differentiation between high-grade glioma and cerebral cortex.
Ishikawa
M
M
Department of Neurosurgery, Kyoto University, Japan.
Kikuchi
H
H
Nishizawa
S
S
Yonekura
Y
Y
D001692:Biological Transport; D002540:Cerebral Cortex / Q000378:metabolism; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism*; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose