title: Aerosol propellant interference with clinical mass spectrometers.
abstract: Metered dose inhalers containing halogenated propellants may interfere with mass spectrometer quantitation of halogenated inhalation anesthetics. We identify the propellant(s) in a commercially available metered dose inhaler that caused erroneous mass spectrometer readings. In addition, we identify the causes of different types of interference in different mass spectrometers.
authors.affiliation: Department of Anesthesiology, University of Washington, Seattle 98195.
authors.forename: E D
authors.initials: ED
authors.lastname: Kharasch
authors.forename: M
authors.initials: M
authors.lastname: Sivarajan
mesh_terms: D000335:Aerosol Propellants / Q000032:analysis*; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000032:analysis*; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000032:analysis; D004737:Enflurane / Q000032:analysis; D007530:Isoflurane / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods
chemical_list: D000335:Aerosol Propellants; D000777:Anesthetics; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; C007783:Freon 114; D004737:Enflurane; C005848:trichlorofluoromethane; D007530:Isoflurane; C007782:dichlorodifluoromethane