Ultraviolet irradiation of the skin attenuates calcitonin gene-related peptide mRNA expression in rat dorsal root ganglion cells.
Calcitonin gene-related peptide (CGRP) mRNA expression in rat dorsal root ganglion cells was measured by polymerase chain reaction after ultraviolet (UV) irradiation of the skin. The aim was to investigate whether a noninvasive peripheral lesion set by UV irradiation influences neuropeptide gene expression thus possibly contributing to the pathophysiology of the UV erythema. Forty-eight hours after irradiation, when the inflammatory response of the skin was at its maximum, there was a decrease in CGRP mRNA levels to 50% of the control values. The results demonstrate that exposure of the peripheral receptive field to noxious UV radiation affects neuropeptide gene expression in primary sensory neurons.
Gillardon
F
F
II. Physiologisches Institut, Universität Heidelberg, F.R.G.
Morano
I
I
Zimmermann
M
M
D000818:Animals; D001483:Base Sequence; D015740:Calcitonin Gene-Related Peptide / Q000096:biosynthesis / Q000235:genetics*; D004890:Erythema / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D015870:Gene Expression; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D012333:RNA, Messenger; D015740:Calcitonin Gene-Related Peptide