Anticalculus effect of a fluoride dentifrice containing triclosan and a copolymer.
A 3-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer, as compared to a placebo dentifrice. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold Index calculus scores obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base or a placebo dentifrice containing 0.243% sodium fluoride in a silica base. A total of 79 adult male and female subjects completed the study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at greater than 97% level of confidence.
Lobene
R R
RR
Forsyth Dental Center, Boston, MA 02115.
Battista
G W
GW
Petrone
D M
DM
Volpe
A R
AR
Petrone
M E
ME
D000328:Adult; D003728:Dental Calculus / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008875:Middle Aged; D011145:Polyvinyls / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
D003802:Dentifrices; D004338:Drug Combinations; D008298:Maleates; D011145:Polyvinyls; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014260:Triclosan; D012969:Sodium Fluoride