title: [Chronic neutrophilic leukemia: apropos of 2 cases and review of the literature].
abstract: Two patients with chronic neutrophilic leukemia, a rare myeloproliferative syndrome, are reported with a review of the literature. The major features of the 34 collected cases (including the two patients reported here) were persistent leukocytosis simulating a leukemoid reaction, hepatosplenomegaly, hyperuricemia, increased vitamin B12 blood level, increased leukocyte alkaline phosphatase and absence of the Philadelphia chromosome. Infection was the leading cause of death. Concomitant multiple myeloma was found in eight patients.
authors.affiliation: Servicio de Medicina Interna, Hospital La Paz, Facultad de Medicina, Universidad Autónoma, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Hidalgo
authors.forename: J
authors.initials: J
authors.lastname: Camacho
authors.forename: J
authors.initials: J
authors.lastname: Fernández
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: F
authors.initials: F
authors.lastname: Poveda
authors.forename: J M
authors.initials: JM
authors.lastname: Peña
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D007955:Leukemoid Reaction / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications
vernacular_title: Leucemia neutrofílica crónica: a propósito de dos casos y revisión de la literatura.