title: [Mechanical aspects of the development of artificial heart valves].
abstract: The development of an antithrombogenic coating permits a hybrid design for artificial heart valves. A substrate material optimized for its application is coated to meet the electrochemical requirements of improved hemocompatibility. But future progress in artificial heart valves requires an improvement in design as well as of the material. The basis of both aspects is the determination of such fundamental mechanical properties as the elasticity and plasticity of the valve ring and the deformation and fraction behaviour of the occluder. Analytical and numerical calculations of various different models result in different requirements for the substrate of ring and occluder. A combination of high elastic temper and low resistance to flow requires a ring material with a Young's modulus of 40 GPa or more, and a 0.2% proof stress to (Young's modulus)2/3 ratio of 0.3 MPa1/3. The best occluder materials should have a Young's modulus of more than 50 GPa and a flexural strength of at least 800 MPa. On the basis of these criteria, a heart valve consisting of a TiA15Fe2,5 ring and occluders made partially stabilized zirconia is introduced.
authors.affiliation: Zentralinstitut für Biomedizinische Technik, Universität Erlangen-Nürnberg.
authors.forename: A
authors.initials: A
authors.lastname: Bolz
authors.forename: M
authors.initials: M
authors.lastname: Schaldach
authors.forename: W
authors.initials: W
authors.lastname: Winter
mesh_terms: D001696:Biomechanical Phenomena; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D013499:Surface Properties
vernacular_title: Mechanische Aspekte bei der Entwicklung künstlicher Herzklappen.