Destructive bone lesions in chronic granulocytic leukemia.
Bone involvement in Chronic Granulocytic Leukemia (CGL) is rare. We describe here five such patients who presented with severe localized bone pain with involvement of femur neck, skull, tibia-upper end and spine. Lesions were osteolytic in three of them. Blast crisis was present in four of them. Survival was poor in all except one who presented in chronic phase. Bone involvement in CGL carries a poor prognosis.
Kumar
L
L
Department of Medical Oncology and Pathology, Cancer Institute (WIA), Tamilnadu, India.
Majhi
U
U
Shanta
V
V
D000328:Adult; D001752:Blast Crisis / Q000473:pathology*; D001847:Bone Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008297:Male; D008875:Middle Aged