title: The effect of nimodipine on outcome after head injury: a prospective randomised control trial. The British/Finnish Co-operative Head Injury Trial Group.
abstract: To study the effect of nimodipine on the outcome of head injury, three hundred and fifty-two patients who were not obeying commands were randomised to placebo or nimodipine (2 mg per hour intravenously for 7 days). The 2 groups were well matched for important prognostic features. Six months after injury, more of the patients who were given nimodipine had a favourable outcome (moderate/good recovery) than in the control group, but the increase in favourable outcome (8%) was not significant statistically.
authors.affiliation: Department of Neurosurgery, Southern General Hospital, Belfast.
authors.forename: G
authors.initials: G
authors.lastname: Teasdale
authors.forename: I
authors.initials: I
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Bell
authors.forename: J
authors.initials: J
authors.lastname: Gray
authors.forename: R
authors.initials: R
authors.lastname: Gullan
authors.forename: U
authors.initials: U
authors.lastname: Heiskanan
authors.forename: P V
authors.initials: PV
authors.lastname: Marks
authors.forename: H
authors.initials: H
authors.lastname: Marsh
authors.forename: A D
authors.initials: AD
authors.lastname: Mendelow
authors.forename: G
authors.initials: G
authors.lastname: Murray
mesh_terms: D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use*; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D009553:Nimodipine