Experimental research on the use of an antineoplastic drug with a bone implant.
In this experiment, we impregnated antineoplastic drugs into bone cement and polyporous ceramics in an attempt to develop a new material which could release the drug, as well as filling a postoperative bony defect. It was shown with cell culture that the drug can be delivered from these materials in vitro. Adriamycin-bone cement can release the drug over a period of 14 days in vitro and for 35 days in vivo in a goat. The times for the adriamycin-ceramic implant were respectively 16 days and 35 days. Microscopy showed only a mild foreign body macrocytic infiltration with the adriamycin-bone cement and a mild nonspecific inflammatory reaction with adriamycin-ceramic implant 9 weeks after operation. The results of treating rat sarcoma 180 with this drug-implant showed a tumour suppression rate of about 54% which is similar to that obtained with systemic chemotherapy. The implant not only fills the postoperative defect, but a high drug concentration locally is maintained, together a low systemic concentration.
Guan
W Y
WY
Othopaedic Department, Tongji Hospital, Wuhan, China.
Yi
W T
WT
Zhi
M Y
MY
Zhen
S S
SS
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001672:Biocompatible Materials; D001843:Bone Cements; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000601:surgery; D002516:Ceramics; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006041:Goats; D006367:HeLa Cells / Q000187:drug effects; D006882:Hydroxyapatites; D066298:In Vitro Techniques; D008297:Male; D008937:Mitomycins / Q000008:administration & dosage; D012510:Sarcoma 180 / Q000188:drug therapy
D001672:Biocompatible Materials; D001843:Bone Cements; D006882:Hydroxyapatites; D008937:Mitomycins; D004317:Doxorubicin; D002945:Cisplatin