title: Transgenic mice as immune system models.
abstract: In the past year, transgenic mice have continued to be powerful models for the investigation of various features of the immune system, particularly for studies of lymphocyte differentiation and tolerance. Major achievements have included the definition of intra-thymic selection events in T-cell differentiation, and the demonstration of extra-thymic tolerance resulting from clonal energy.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Morahan
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D005544:Forecasting; D007107:Immune System; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology*; D008954:Models, Biological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
chemical_list: D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell