[Expression of HLA-class I and II antigens on basal cell carcinoma].
Sixteen cases of Basal Cell Carcinoma have been tested with monoclonal antibodies to HLA-class I, beta 2-microglobulin, HLA-DR, DP and DQ antigens immunohistochemically using frozen tissues. HLA-class I antigens were expressed weakly on BCC in thirteen and fifteen out of sixteen cases using two different monoclonal antibodies respectively. beta 2-microglobulin was expressed differently with the same intensity as normal epidermis in 6 cases, weaker than normal epidermis in 8 cases and absent in 2 cases. There is no correlation with the expression of HLA-class I between histological type and lymphocyte infiltration. On the other hand, HLA-DR, DP and DQ antigens were positive in 4, 3 and 3 cases respectively. But the percentage of positive cells for HLA-class II were only 1-2%. The expression of HLA-DR antigen was most strongest among HLA-class II antigens.
Nakamura
T
T
Department of Dermatology, Kumamoto University Medical School.
Kageshita
T
T
Hirai
S
S
Kimura
T
T
Yoshii
A
A
Ono
T
T
Arao
T
T
D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology*
D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II