[Induction of micronuclei in polychromatic erythrocytes from mouse bone marrow following intraperitoneal administration of halogenated benzenes].
The mutagenicity of halogenated benzenes, including three isomers of tri- and tetrachlorobenzenes (TCB, TeCB) was studied on male Swiss CD1 mice by MN test. The data presented show that all the halogenated benzenes tested were found to be clastogenic apart from 1,2,3,5-TeCB. No significant differences were observed in the clastogenic activities of TCB-isomers and TeCB-isomers.
Parrini
M
M
Istituto Nazionale per la Ricerca sul Cancro, Genova.
Bolognesi
C
C
Roggieri
P
P
D000818:Animals; D001554:Benzene / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002722:Chlorobenzenes / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
D002722:Chlorobenzenes; C030387:1,2,3,5-tetrachlorobenzene; D001554:Benzene
Induzione di micronuclei in eritrociti policromatici di midollo osseo di topo in seguito a somministrazione intraperitoneale di alogeno-benzeni.