[Antiglaucoma ophthalmic agents with prolonged action based on macromolecular excipients. 1. In vitro studies].
Hydrogels and Hydrosols based on sodium carboxymethyl-cellulose (NaCMC), polyvinylpyrrolidone (PVP) and polyacrylic acids (PAS) Carbopol 940, Scopacryl D 339 (PAS-B) and PAS-Fluka (PAS-F) were investigated in vitro for rheological properties and pilocarpine release. The gels showed diffusion coefficients in the series Carbopol 940 1% greater than NaCMC 3% greater than PAS-F 3.5% greater than PVP K 90 23% greater than PAS-B 8% greater than PAS-F 7%. Especially PAS-F proved suitable for prolonged release, also in liquid preparations. Lyophilizated pilocarpine polymer-salts which were prepared from PAS-F and pilocarpine base, both in effect of retardation and in drug stability showed important advantages compared with aqueous solution of pilocarpine.
Pergande
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Sektion Chemie, Humboldt-Universität zu Berlin.
Keipert
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D000180:Acrylic Resins; D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D004355:Drug Stability; D005079:Excipients; D005901:Glaucoma / Q000188:drug therapy*; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage*; D011205:Povidone; D013242:Sterilization; D014783:Viscosity
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005079:Excipients; D009883:Ophthalmic Solutions; D010862:Pilocarpine; C006903:carbopol 940; D011205:Povidone; D002266:Carboxymethylcellulose Sodium
Antiglaukomatosahaltige Ophthalmika mit prolongierter Wirkung auf Basis makromolekularer Hilfsstoffe. Teil 1: In vitro-Untersuchungen.