Denatonium saccharide as an aversive stimulus in a conditioned taste aversion paradigm.
The ability of denatonium saccharide (DS) to function as an aversive stimulus for the rat was studied in a conditioned taste-aversion paradigm in two experiments. Exp. 1 assessed the effects of DS during a 30-min. access period when only a saccharin solution was available. Exp. 2 assessed the effects of DS during both a 10- and a 30-min. access period when a saccharin solution and free water were available. The results showed that DS did not attenuate saccharin consumption reliably over all test days. The effect was most apparent during the 10-min. interval when free water was available. These results, together with previous reports, suggest that DS appears to function as a weak aversive stimulus in the rat.
June
H L
HL
University of the District of Columbia.
Hicks
L H
LH
Lewis
M J
MJ
Ross
S
S
D000818:Animals; D001245:Association Learning; D001362:Avoidance Learning; D003214:Conditioning, Classical; D004326:Drinking; D008297:Male; D000644:Quaternary Ammonium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste; D013652:Taste Threshold
D000644:Quaternary Ammonium Compounds; C053525:denatonium saccharide