Cerebral ischemia, locomotor activity and spatial mapping.
A 5-min bilateral occlusion of the carotid arteries produced large increases in gerbil locomotor activity that persisted for a week of daily testing after the ischemic episode. In a second group of animals, 5 days of pre-exposure to the open-field prior to inducing ischemia blocked the development of increased locomotor activation. These results suggest that the increased locomotor activity resulting from cerebral ischemic damage is not a simple form of motor hyperactivity. Instead, this change in behavior may represent a reduction of the ischemic animal's ability to form spatial maps.
Wang
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Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Corbett
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D000818:Animals; D001931:Brain Mapping; D002470:Cell Survival / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000523:psychology*; D009043:Motor Activity / Q000502:physiology*