[Immunomodulator effects of 2 kinds of interferon alpha on the in vitro synthesis of systemic and articular interleukin 1 in rheumatoid polyarthritis].
The authors have studied the synthesis of interleukin 1 by articular and circulating macrophages and the effect of two types of interferon alpha (IF) on this synthesis in 20 patients with untreated rheumatoid arthritis (RA). The articular and especially systemic interleukin levels in the RA patients are significantly higher than those of the test subjects. Interferon modifies in a very different way the production of interleukin 1 in the patients and in the test subjects. This is linked with the in vitro experimental conditions as well as the increase in the IL1 levels in the patients. The authors discuss the perspective therapeutics offered by this modulation of interleukin production by interferon.
Voicoulesco
C
C
Service de Microbiologie, Faculté de Médecine, Craiova, Roumanie.
Ghyka
G
G
Rogoz
S
S
Rosu
L
L
Dumitresco
M
M
Costache
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D007596:Joints / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D007375:Interleukin-1; D011994:Recombinant Proteins
Les effets immunomodulateurs de deux sortes d'interféron alpha sur la synthèse in vitro d'interleukine 1 systémique et articulaire au cours de la polyarthrite rhumatoïde.