title: Pediatric heart transplantation for congenital heart disease and cardiomyopathy.
abstract: Orthotopic heart transplantation has become an accepted therapy for adult patients with end-stage heart disease. In newborns and infants, this procedure is still controversial because of the unknown long-term results and the lack of donor organs. Since March 1988, we have performed orthotopic heart transplantation in 11 infants and children with hypoplastic left heart syndrome (n = 6), cardiomyopathy (n = 4), or congenital endocardial fibroelastosis (n = 1). The smallest infant was 3 days old and weighed 2,650 g. Four of 15 potential donors had to be refused for various medical reasons, and 4 were transferred to our hospital for organ retrieval. Seven hearts were procured remotely. We accepted weight mismatches up to 105% between donor and recipient. There were three perioperative deaths, two in patients 5 and 17 days old with hypoplastic left heart syndrome and 1 in a 2-year-old patient with a dilated cardiomyopathy. All 3 patients had drug-resistant right heart failure. A 2-year-old girl with a dilated cardiomyopathy died 2 months after transplantation owing to severe pulmonary embolism originating from the superior vena cava. The remaining 7 patients are alive and well between 1 month and 31 months after transplantation. Angiographic follow-up has not revealed signs of graft atherosclerosis at 2 years.
authors.affiliation: Department of Cardiovascular Surgery, Justus-Liebig-University, Giessen, Germany.
authors.forename: F W
authors.initials: FW
authors.lastname: Hehrlein
authors.forename: H
authors.initials: H
authors.lastname: Netz
authors.forename: R
authors.initials: R
authors.lastname: Moosdorf
authors.forename: F
authors.initials: F
authors.lastname: Dapper
authors.forename: H H
authors.initials: HH
authors.lastname: Scheld
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: J
authors.initials: J
authors.lastname: Boldt
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006330:Heart Defects, Congenital / Q000601:surgery*; D016027:Heart Transplantation / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015996:Survival Rate