Levamisole treatment of oligospermia.
On the basis of elevated levels of seminal plasma immunoglobulins and a decreased production of LMI in the presence of PPD, 6 patients (out of the idiopathic normogonadotrophic oligospermic group) were selected for a therapeutic trial with levamisole. The following regime of treatment was applied: 3 days on levamisole (150 mg per day) followed by a 10 day interval without treatment, for a period of three months. The sperm count increased in 5 out of 6 patients and motility increased in 2. At the same time a reduction in seminal plasma IgG levels was observed in all treated patients. A significant increase of EA rosettes was observed after treatment.
Würzburger
M I
MI
Endocrinology Department and Laboratory for Immunology, Zvezdara Medical Centre, Beograd.
Prelević
G M
GM
Brkić
S D
SD
Vucković
S
S
Despotović
N
N
Milović
V
V
D002464:Cell Migration Inhibition; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007978:Levamisole / Q000627:therapeutic use*; D016131:Lymphocyte Subsets; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000276:immunology
D007136:Immunoglobulins; D007978:Levamisole