title: [Benzisoselenazolinones and their derivatives, a new series of anti-inflammatories and antioxidants].
abstract: Ebselen, a benzisoselenazolinone, displays antiinflammatory properties and antioxidant capacity similar to the enzyme glutathione peroxydase. Structural modifications were realized. The presence of substituents ortho to selenium, and in particular of a dipolar group such as -NO2, led to an interesting modification of the pharmacological properties.
authors.affiliation: Université de Liège, Service de Chimie Organique, Belgique.
authors.forename: M
authors.initials: M
authors.lastname: Renson
authors.forename: N
authors.initials: N
authors.lastname: Dereu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000975:Antioxidants / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology*; D054833:Isoindoles; D051379:Mice; D016566:Organoselenium Compounds; D012643:Selenium / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D012643:Selenium
vernacular_title: Les benzisosélénazolinones et leurs dérivés, nouvelle série d'antiinflammatoires et d'antioxydants.