[The effect of ginger on serotonin induced hypothermia and diarrhea].
One of the important medicinal properties of ginger is known to remove chills caused by common cold and to warm body. In the present study, acetone extract of ginger at 100 mg/kg p.o. significantly inhibited serotonin (5-HT) induced hypothermia. Therefore, the active constituents of ginger were further examined. The acetone extract was functioned into 4 fractions by column chromatography. Fractions 1 and 2 showed significant activity. Fraction 2 was further purified and [6]-shogaol which was obtained from fraction 2-2, at 10 mg/kg p.o. was shown to inhibit 5-HT induced hypothermia. Anticathartic activity is known to be one of the medicinal effects of ginger. In the present study, acetone extract of ginger at 75 mg/kg p.o., significantly inhibited 5-HT induced diarrhea. In order to clarify the active constituents, the acetone extract was fractionated into 4 fractions by silica gel chromatography. Fractions 2 and 3, which was especially effective, were further purified and [6]-shogoal, [6]-dehydrogingerdione, [8]- and [10]-gingerol were found to have an anticathartic action. [6]-Shogaol was more potent than [6]-dehydrogingerdione, [8]- and [10]-gingerol.
Huang
Q
Q
Kyoto Pharmaceutical University, Japan.
Matsuda
H
H
Sakai
K
K
Yamahara
J
J
Tamai
Y
Y
D000096:Acetone / Q000494:pharmacology*; D000818:Animals; D002396:Catechols / Q000494:pharmacology; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D005233:Fatty Alcohols / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced / Q000188:drug therapy*; D007650:Ketanserin / Q000494:pharmacology; D051379:Mice; D010869:Pindolol / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal; D012701:Serotonin / Q000494:pharmacology*
D002396:Catechols; D005233:Fatty Alcohols; D010936:Plant Extracts; D000096:Acetone; D012701:Serotonin; C040115:shogaol; C007845:gingerol; D007650:Ketanserin; D010869:Pindolol