Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells.
The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids.
Djaldetti
R
R
Department of Medicine B, Golda Medical Center, Hasharon Hospital, Petah Tikva, Israel.
Fishman
P
P
Shtatlender
V
V
Sredni
B
B
Djaldetti
M
M
D003864:Depression, Chemical; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007375:Interleukin-1 / Q000493:pharmacokinetics*; D007377:Interleukin-3 / Q000493:pharmacokinetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D013997:Time Factors
D007375:Interleukin-1; D007377:Interleukin-3; D003907:Dexamethasone