title: Application of a simplified in-vivo test system for determining chloroquine resistance in Plasmodium falciparum.
abstract: A simplified in-vivo test system was applied to detect chloroquine resistance in malaria patients in Shahjahanpur district (Uttar Pradesh) in India. In 27.6% of cases RIII resistance was observed. This in-vivo method is a simple and useful test for the early detection of chloroquine-resistant falciparum infections and for the management of these patients with alternative therapy.
authors.affiliation: Malaria Research Centre, Sadar Bazar, Shahjahanpur, India.
authors.forename: R N
authors.initials: RN
authors.lastname: Prasad
authors.forename: H
authors.initials: H
authors.lastname: Prasad
authors.forename: K J
authors.initials: KJ
authors.lastname: Virk
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D013415:Sulfalene / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C050416:metakelfin; D002738:Chloroquine; D013415:Sulfalene; D011739:Pyrimethamine