[The effect of aspirin and indomethacin on intracellular pH and on the activation of the Na+/H+ antiporter in neutrophils].
Using microfluorometry, aspirin and indomethacine effects on intracellular pH and Na+/H+ neutrophilic antiporter activation were studied. Aspirin and indomethacine were shown to decrease intracellular pH of quiescent neutrophil cells. Aspirin completely blocked basifying of cytoplasm, which is resulted from Na+/H+ neutrophilic antiporter activation.
Piruzian
L A
LA
Galkina
S I
SI
D001241:Aspirin / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000097:blood*
D003208:Concanavalin A; D006859:Hydrogen; D012964:Sodium; D001241:Aspirin; D001920:Bradykinin; D007213:Indomethacin
Vliianie aspirina i indometatsina na vnutrikletochnyĭ pH i aktivatsiiu Na+/H+ antiportera neĭtrofilov.