[Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides].
Total and non-sedimentable activity of cathepsins A, B, C and D in rat liver tissue as well as activity of these lysosomal proteinases in blood serum were studied during intragastric administration of tetramethyl thiuramdisulfide (TMTD), polymartsine and tsineb within 30 days at a dose of 1/20 LD50. The enzymatic activity alterations, which involved a decrease in total activity of lysosomal proteinases and an increase of the activity in non-sedimentable fraction and blood serum, were distinctly decreased in series: TMTD--polymartsine--tsineb. The data obtained suggest that structure-functional state of lysosomes was considerably altered in response to the effect of dithiocarbamate-containing pesticides.
Shubitidze
T M
TM
Busova
T N
TN
Riazanova
R A
RA
Tabagari
S I
SI
D000818:Animals; D002219:Carbamates; D010450:Endopeptidases / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D000637:Transaminases / Q000378:metabolism
D002219:Carbamates; D007306:Insecticides; D000637:Transaminases; D010450:Endopeptidases
Strukturno-funktsional'noe sostoianie lizosomnogo apparata pecheni krys pri deĭstvii pestitsidov ditiokarbamatnogo riada.