The effect of long acting somatostatin analogue SMS 201.995 therapy on tumour kinetic measurements and serum tumour marker concentrations in primary rectal cancer.
Twelve patients with rectal carcinoma were treated for 2 weeks with the somatostatin analogue SMS 201.995. Effects of this therapy were assessed using serum marker concentration, Ki67 and gastrin-immunoreactivity of the primary tumour. In four out of 12 patients, a significant decrease in Ki67 immunoreactivity was seen during SMS 201.995 treatment while in the remaining eight patients there was no significant change in Ki67 expression. Four patients had elevated pretreatment serum carcinoembryonic antigen (CEA) levels. In two of these four patients, serum CEA levels fell modestly during SMS 201.995 therapy. This is the first clinical evidence that a somatostatin analogue can inhibit the growth of some colorectal cancers.
Iftikhar
S Y
SY
Department of Surgery, University Hospital, Nottingham, UK.
Watson
S A
SA
Morris
D L
DL
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D005755:Gastrins / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D019394:Ki-67 Antigen; D007700:Kinetics; D009687:Nuclear Proteins / Q000032:analysis*; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005755:Gastrins; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D015282:Octreotide