title: [The biological properties of production strain 205 of the tick-borne encephalitis virus. Its virulence, thermostability and resistance to the action of urea].
abstract: The characterization of such properties of tick-borne encephalitis virus strain 205 and its clones as virulence, thermal stability and sensitivity to 2.5 M urea was obtained. The following combination of the genetic markers of strain 205 was established: mNic+, mNsc+, T50+, Ur. The clones possessed pronounced virulence, but showed different heat sensitivity (T50+, T50 +/-) and resistance to the action of urea (Ur and U +/-). At the early terms of observation, the clone isolated from a large viral plaque was more antigen-active.
authors.forename: I V
authors.initials: IV
authors.lastname: Kotykhov
authors.forename: N N
authors.initials: NN
authors.lastname: Kiseleva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Fedorov
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D004352:Drug Resistance, Microbial; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D006168:Guinea Pigs; D006358:Hot Temperature; D051379:Mice; D014508:Urea / Q000037:antagonists & inhibitors*; D014774:Virulence
chemical_list: D000956:Antigens, Viral; D014508:Urea
vernacular_title: Izuchenie biologicheskikh svoĭstv proizvodstvennogo shtamma 205 virusa kleshchevogo éntsefalita. Virulentnost', termostabil'nost' i ustoĭchivost' k deĭstviiu mocheviny.