title: Free radical scavenging: a potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors.
abstract: Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10(-5) M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.
authors.affiliation: Department of Chemistry, Strathclyde University, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Chopra
authors.forename: J
authors.initials: J
authors.lastname: McMurray
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: H J
authors.initials: HJ
authors.lastname: Dargie
authors.forename: W E
authors.initials: WE
authors.lastname: Smith
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D002216:Captopril / Q000031:analogs & derivatives / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers; D006801:Humans; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D016166:Free Radical Scavengers; C044958:zofenopril; D002216:Captopril