Synthetic and pharmacological studies on some transition metal chelates involving N-pyrimidino benzamide-2-carboxylic acid as ligand.
N-pyrimidino benzamide-2-carboxylic acid (NPBCA) and its Cu(II), Ni(II), Co(II), Zn(II), and Mn(II) chelates have been synthesized and characterized by using elemental analyses, molar conductance, molecular weight determination, magnetic moment, infrared, and electronic spectra. Antifungal activity of the synthesized compounds has been screened on common fungi, viz., Aspergillus niger, Aspergillus nidulense, and Candida albicans at 28 degrees C and antibacterial activity has been observed on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria at 37 degrees C. Anti-inflammatory and ulcerogenic potential of the synthesized compounds have been discussed.
Nagar
R
R
Department of Chemistry, Agra University, Khandari, India.
Mohan
G
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008280:Magnetics; D008297:Male; D008670:Metals; D008970:Molecular Weight; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D014456:Ulcer / Q000139:chemically induced
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D002614:Chelating Agents; D008024:Ligands; D008670:Metals; D011743:Pyrimidines; C069841:N-pyrimidinobenzamide-2-carboxylic acid