title: [Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by alpha-naphthylisothiocyanate in rats].
abstract: Sixty seven methanol extracts of crude drugs were examined for their effects to protect hepatic injury induced by alpha-naphthylisothiocyanate (ANIT) in rats. In terms of the release of intrahepatic enzymes and bilirubin into the serum, 19 extracts were found to suppress the increase in the concentration of serum bilirubin by ANIT. Out of the 19 extracts those of Berchemia Racemosa Caulis, Aurantii Nobilis Pericarpium, Polygoni Avicularis Herba and Gentianae Scabrae Radix, also inhibited the release of several intrahepatic enzymes used as parenchymal injury parameter.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kumazawa
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: S H
authors.initials: SH
authors.lastname: Tu
authors.forename: A
authors.initials: A
authors.lastname: Kamogawa
authors.forename: M
authors.initials: M
authors.lastname: Shinoda
mesh_terms: D015058:1-Naphthylisothiocyanate; D000818:Animals; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003864:Depression, Chemical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000201:enzymology; D008297:Male; D000432:Methanol; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004365:Drugs, Chinese Herbal; D015058:1-Naphthylisothiocyanate; D001663:Bilirubin; D000432:Methanol