The transition of benign to malignant in epithelial and mesenchymal tumours.
Following publication in this journal of a 4 mutation-model of oncogenesis some points of controversy emerged which are discussed. In particular an explanation is offered for the differences in histogenesis of epithelial and non-epithelial tumours. Some clinical features of benign tumours are also clarified.
Koten
J W
JW
Instituut voor Pathologie, Academisch Ziekenhuis Utrecht, The Netherlands.
Den Otter
W
W
D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D012509:Sarcoma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*