[Experimental study of combined effects of benzo(a)pyrene and ortho-cresol on the body].
Ortho-cresol (o-cresol) produces a modifying influence on the effect produced by benz/a/pyrene (BP) under mice CC57B exposure to the combined peroral administration of the two chemicals. A low-toxic dose of o-cresol (Img) abruptly activates the effect of the same dose of BP (1 mg) according to all parameters (increase of the frequency, coefficient of multiplicity and degree of malignancy of tumours, shortening of the latency period) and somewhat inhibits its activity when administered before or after BP. Simultaneous administration of o-cresol in a ++super-toxic dose (10 mg) and BP in an optimal dose (5 mg) does not change the frequency of tumours, as compared to the control, however, inhibits the progression of induces neoplasms, which is manifest in the decrease of the frequency of malignancy, multiplicity of appearance and lengthening of the time of the onset of their malignization. Simultaneous administration of o-cresol in the dose relevant to the MAC for water does not change the carcinogenic activity of BP, which testifies to the necessity of sanitary control of observing hygienic regulations for both chemicals, as the most effective measure of prophylaxis of the malignant tumours morbidity of the population.
Ianysheva
N Ia
NIa
Balenko
N V
NV
Chernichenko
I A
IA
Bakanova
G N
GN
Lemeshko
L P
LP
Babiĭ
V F
VF
D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000009:adverse effects*; D003043:Cocarcinogenesis; D003408:Cresols / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D051379:Mice; D013274:Stomach Neoplasms / Q000139:chemically induced*
D003408:Cresols; D004338:Drug Combinations; D001564:Benzo(a)pyrene; C034047:2-cresol
Eksperimental'noe izuchenie kombinirovannogo deĭstviia benz(a)pirena i ortokrezola na organizm.