title: [Characteristics of pathogenesis of acute leukemia in children].
abstract: The main components of acute leukemia pathogenesis have been considered from the current positions: origination of the leukemic clone, characteristics of leukemia tumor histogenesis, mechanisms of proliferation and differentiation of leukemic cells. The main pathogenetic differences of acute leukemia in children and adults have been traced. The importance of these differences for the clinical picture, prognosis and response to chemotherapy has been analyzed.
authors.forename: E B
authors.initials: EB
authors.lastname: Vladimirskaia
authors.forename: A G
authors.initials: AG
authors.lastname: Rumiantsev
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division / Q000502:physiology; D002648:Child; D002999:Clone Cells / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D009857:Oncogenes / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000209:etiology* / Q000235:genetics / Q000473:pathology
vernacular_title: Osobennosti patogeneza ostrykh leĭkozov u deteĭ.