Report of studies on monoclonal antibodies (MABS) to complement components.
Twenty-five monoclonal antibodies (MABS) to complement components were evaluated according to the ISBT/ICSH protocol by twelve laboratories. Seven detected some form of C3c, but one of them, 174, did not react with EiC3b, although it was positive with 'EC3b' (Fruitstone). 174 may detect some form of enzyme sensitive C3b antigen, but C3a was not evaluated (present on 'EC3b' Fruitstone). Twelve of the antibodies were anti-C3d, one was an anti-C3g and five were anti-C4c.
Voak
D
D
Regional Transfusion and Immuno-Haematology Centre, Cambridge, U.K.
Nilsson
U
U
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D015932:Complement C3c / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D015935:Complement C4b; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D010446:Peptide Fragments
D000911:Antibodies, Monoclonal; D003181:Complement C4; D010446:Peptide Fragments; C033860:complement C4c; D015932:Complement C3c; D015935:Complement C4b; D003165:Complement System Proteins