title: [A comparative evaluation of the permeability of the dura mater in parturients and the efficacy of epidural anesthesia using morphine following cesarean section].
abstract: Spinal dura mater permeability has been compared in 15 women dead in labour or of severe multiple combined traumas. The quantitative index for the assessment of transmeningeal morphine and dicaine diffusion was permeability coefficient calculated according to Fick's equation. It has been shown that in late pregnancy dura mater permeability for morphine and dicaine increases by 18.6% and 23.5%, respectively. However, a decrease of the diffusion barrier is not clinically manifested during epidural morphine analgesia due to an equivalent increase in the rate of intravascular opiate adsorption. The conclusion is made that it is advisable to add the usual adrenaline dose (1:200,000) to the anesthetic solution to enhance the degree of anesthesia adequacy and to decrease the danger of the onset of general narcotic and respiratory depression on the fetus in the early neonatal period.
authors.forename: I A
authors.initials: IA
authors.lastname: Vitenbek
mesh_terms: D000328:Adult; D016362:Analgesia, Obstetrical; D002585:Cesarean Section; D004388:Dura Mater; D005260:Female; D006801:Humans; D009020:Morphine / Q000493:pharmacokinetics; D010149:Postoperative Pain / Q000517:prevention & control*; D010539:Permeability; D011247:Pregnancy; D013748:Tetracaine / Q000493:pharmacokinetics
chemical_list: D013748:Tetracaine; D009020:Morphine
vernacular_title: Sopostavitel'naia otsenka pronitsaemosti tverdoĭ mozgovoĭ obolochki u rodil'nits i éffektivnosti épidural'noĭ analgezii morfinom posle kesareva secheniia.