title: Acyclovir-induced acute tubulo-interstitial nephritis.
abstract: Two patients with presumed herpes simplex encephalitis developed severe non-oliguric acute renal failure shortly after acyclovir infusions. Renal function returned to normal in less than 3 weeks after discontinuation of acyclovir. Renal biopsies done during the acute phase demonstrated interstitial oedema, eosinophils and cellular aggregates in both and granulomata in the second case suggesting acyclovir-induced hypersensitivity interstitial nephritis.
authors.affiliation: Department of Medicine, Hamad General Hospital, Doha, Qatar.
authors.forename: A
authors.initials: A
authors.lastname: Rashed
authors.forename: B
authors.initials: B
authors.lastname: Azadeh
authors.forename: S H
authors.initials: SH
authors.lastname: Abu Romeh
mesh_terms: D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D004660:Encephalitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000212:Acyclovir