Therapeutic effects of topical dexamethasone on experimental brain tumours and peritumoural brain oedema.
Topical application of dexamethasone to brain tumour bed retains its biological effectiveness in controlling peritumoural brain oedema, possibly through the oncolytic mechanism (cytostatic effect). The question rises, whether the systemic administration of dexamethasone can be duplicated with dexamethasone topically to the brain tumour bed.
Ikeda
Y
Y
Department of Neurosurgery, Nippon Medical School, Tokyo, Japan.
Carson
B S
BS
Long
D M
DM
D000287:Administration, Topical; D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000517:prevention & control*; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D012016:Reference Values; D013046:Specific Gravity
D003907:Dexamethasone