title: Spectrophotometric determination of tilidine using bromocresol green and bromophenol blue.
abstract: A spectrophotometric method is described for the determination of tilidine in its dosage forms (injection, drops, suppositories). The method is based on ion-pair extraction with chloroform at pH 3.5 using bromocresol green or bromophenol blue as the ion-pairing reagents. The spectrophotometric measurements are carried out at the absorption maxima at 415 and 411 nm, respectively.
authors.affiliation: Institute of Pharmaceutical Chemistry Faculty of Pharmacy, Belgrade, Yugoslavia.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Dobrila
authors.forename: S
authors.initials: S
authors.lastname: Ljiljana
authors.forename: Z
authors.initials: Z
authors.lastname: Ljiljana
mesh_terms: D001961:Bromcresol Green; D001978:Bromphenol Blue; D007202:Indicators and Reagents; D013053:Spectrophotometry / Q000379:methods; D013993:Tilidine / Q000032:analysis*
chemical_list: D007202:Indicators and Reagents; D001978:Bromphenol Blue; D001961:Bromcresol Green; D013993:Tilidine