The effect of tacrine on acetylcholine overflow in the heart.
Tacrine, 10(-6) M, enhanced the acetylcholine (ACh) overflow evoked in perfused chicken hearts by field stimulation (5 Hz, 1 min) from 183 to 346 pmol g-1 min-1. Increase to the same level were observed after pretreatment with diisopropylfluorophosphate (DFP) as well as after DFP plus 10(-6) M tacrine. Tacrine, 10(-5) M, caused further enhancement with or without DFP up to 851 pmol g-1 min-1. It was concluded that 10(-6) M tacrine enhanced the ACh overflow by choline esterase inhibition, whereas 10(-5) M tacrine caused, in addition, an increase of neuronal ACh release.
Lindmar
R
R
Department of Pharmacology, University of Mainz, F.R.G.
Löffelholz
K
K
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D004558:Electric Stimulation; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007531:Isoflurophate / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D013619:Tacrine / Q000494:pharmacology*
D007531:Isoflurophate; D013619:Tacrine; D000109:Acetylcholine