Treatment of cutaneous sarcoidosis with chloroquine. Review of the literature.
Systemic corticosteroids may be either contraindicated or not efficacious in treating the cutaneous manifestations occurring in 20% to 35% of patients with systemic sarcoidosis. Chloroquine phosphate has been reported to be a valuable alternative therapy for cutaneous lesions of sarcoidosis. With a judiciously determined daily dosage and regular 6-month ophthalmologic follow-up examinations, the risk of developing retinopathy can be avoided, because the daily dosage rate rather than total dose accumulation determines the development of chloroquine-induced retinopathy. We reviewed the efficacy and safety of chloroquine and its role in the treatment of cutaneous sarcoidosis.
Zic
J A
JA
Division of Dermatology, Vanderbilt School of Medicine, Nashville, Tenn. 37232.
Horowitz
D H
DH
Arzubiaga
C
C
King
L E
LE
D002738:Chloroquine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012507:Sarcoidosis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*
D002738:Chloroquine