[The ratio between the concentrations in mouse blood and tissues of active forms of diazepam measured by the radioreceptor method].
The summary levels of diazepam and its metabolites in the mouse serum, brain and liver tissues were determined by the radioreceptor assay after single intraperitoneal administration of seduxen in a dose of 4 mg/kg. The results showed synchronism of changes of the concentrations in the brain and liver and in the serum. The correlation coefficients between the brain or liver concentrations and the serum one were 0.82 and 0.91, respectively. The second peak of the tissue concentrations of diazepam active forms and the local minimum at this time in the serum were observed 2.5 hours after the drug administration. The results obtained may be considered as the experimental basis of using the blood diazepam active form concentrations measured by RRA for the therapeutic control of diazepam application in the clinic.
Beliaeva
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D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003975:Diazepam / Q000032:analysis / Q000493:pharmacokinetics*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051379:Mice; D011869:Radioligand Assay; D013997:Time Factors; D014018:Tissue Distribution
D003975:Diazepam
Sootnoshenie mezhdu kontsentratsiiami v krovi i tkaniakh mysheĭ aktivnykh form diazepama, izmerennykh radioretseptornym metodom.