Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells.
We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity.
Bianchi
M
M
Laboratory of Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Mantovani
A
A
Erroi
A
A
Dinarello
C A
CA
Ghezzi
P
P
D000551:Ambroxol / Q000494:pharmacology*; D002478:Cells, Cultured; D004926:Escherichia coli; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D000551:Ambroxol