title: Reversal of resistance to doxorubicin with cepharanthine in murine P388 leukemia cells.
abstract: Cytotoxic effect in vitro and antitumor effect in vivo of doxorubicin (DOX) combined with cepharanthine were investigated on DOX-resistant murine P388 leukemia (P388/R) cells. Cepharanthine was minimally cytotoxic in the cell line, but reversed DOX-resistance in a dose-related manner in P388/R cells. The administration of cepharanthine to mice bearing the P388 leukemia enhanced the antitumor activity of DOX. These results indicate that cepharanthine is an effective agent to reverse DOX-resistant cells.
authors.affiliation: Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujimura
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: I
authors.initials: I
authors.lastname: Maekawa
authors.forename: S
authors.initials: S
authors.lastname: Furusawa
authors.forename: H
authors.initials: H
authors.lastname: Kawauchi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D007941:Leukemia P388 / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014407:Tumor Cells, Cultured / Q000187:drug effects; D052117:Benzodioxoles
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D004317:Doxorubicin; C006947:cepharanthine; D052117:Benzodioxoles