Susceptibilities of Mycobacterium fortuitum biovar. fortuitum and the two subgroups of Mycobacterium chelonae to imipenem, cefmetazole, cefoxitin, and amoxicillin-clavulanic acid.
MICs of imipenem, cefoxitin, cefmetazole, and amoxicillin-clavulanic acid were determined against 100 strains of Mycobacterium fortuitum and 200 strains of Mycobacterium chelonae. Imipenem and cefmetazole were more active against M. fortuitum than cefoxitin was, and imipenem (which inhibited 39% of strains at 8 micrograms/ml) was the only beta-lactam active against M. chelonae subsp. chelonae.
Wallace
R J
RJ
Department of Microbiology, University of Texas Health Center, Tyler 75710.
Brown
B A
BA
Onyi
G O
GO
D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015311:Cefmetazole / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D002969:Clavulanic Acids / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology; D015378:Imipenem / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D015311:Cefmetazole; D002440:Cefoxitin; D015378:Imipenem; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin