[Putrescine in evaluation of the leukemic process in children].
Relationship between elevated putrescine level in urine and its presence in the blood and bone marrow was analyzed in 44 children with acute leukemia in the active stage. It has been shown that putrescine is a marker of activation of leukemic proliferation that is confirmed by the disease course character in patients with elevated putrescine level in urine (66.3 +/- 5.1 mumols/day) and its presence in the blood and bone marrow. Putrescine can serve as an early precursor of relapses during investigation of patients in the remission state.
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D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D011379:Prognosis; D011700:Putrescine / Q000737:chemistry / Q000378:metabolism*; D012074:Remission Induction
D011700:Putrescine
Putrescin v otsenke aktivnosti leĭkoznogo protsessa u deteĭ.