title: Hibiclens keratopathy. A clinicopathologic case report.
abstract: A 39-year-old woman developed a painful, red eye immediately following oral surgery associated with preoperative preparation of her face with the antiseptic, Hibiclens. Epithelial and stromal edema was observed 2 weeks after surgery and progressed to diffuse bullous keratopathy. This led to penetrating keratoplasty 10 months later. Light and electron microscopic findings of the cornea included epithelial edema with bullous changes, marked loss of keratocytes, a thickened Descemet's membrane, and an attenuated, disrupted endothelial cell layer. These findings demonstrate the corneal damage that may occur following ocular exposure to Hibiclens.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, Ohio 44195-5024.
authors.forename: G A
authors.initials: GA
authors.lastname: Varley
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: S C
authors.initials: SC
authors.lastname: Benes
authors.forename: J T
authors.initials: JT
authors.lastname: McMahon
authors.forename: Z N
authors.initials: ZN
authors.lastname: Zakov
authors.forename: A
authors.initials: A
authors.lastname: Fryczkowski
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D015715:Corneal Edema / Q000139:chemically induced / Q000473:pathology; D003319:Corneal Stroma / Q000187:drug effects / Q000648:ultrastructure; D003886:Descemet Membrane / Q000187:drug effects / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008855:Microscopy, Electron, Scanning
chemical_list: C010882:chlorhexidine gluconate; D002710:Chlorhexidine