title: [Structure-activity status of the rat liver lysosomal apparatus upon the action of dithiocarbamate pesticides].
abstract: Total and non-sedimentable activity of cathepsins A, B, C and D in rat liver tissue as well as activity of these lysosomal proteinases in blood serum were studied during intragastric administration of tetramethyl thiuramdisulfide (TMTD), polymartsine and tsineb within 30 days at a dose of 1/20 LD50. The enzymatic activity alterations, which involved a decrease in total activity of lysosomal proteinases and an increase of the activity in non-sedimentable fraction and blood serum, were distinctly decreased in series: TMTD--polymartsine--tsineb. The data obtained suggest that structure-functional state of lysosomes was considerably altered in response to the effect of dithiocarbamate-containing pesticides.
authors.forename: T M
authors.initials: TM
authors.lastname: Shubitidze
authors.forename: T N
authors.initials: TN
authors.lastname: Busova
authors.forename: R A
authors.initials: RA
authors.lastname: Riazanova
authors.forename: S I
authors.initials: SI
authors.lastname: Tabagari
mesh_terms: D000818:Animals; D002219:Carbamates; D010450:Endopeptidases / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D000637:Transaminases / Q000378:metabolism
chemical_list: D002219:Carbamates; D007306:Insecticides; D000637:Transaminases; D010450:Endopeptidases
vernacular_title: Strukturno-funktsional'noe sostoianie lizosomnogo apparata pecheni krys pri deĭstvii pestitsidov ditiokarbamatnogo riada.