A canine model of hyperdynamic sepsis induced by intestinal ischemia.
A hyperdynamic sepsis model was developed in dogs. It is based on a 3-hour clamping of the arteries supplying the middle portion of the jejunum. The ensuing sepsis has a course of several days, during which the animals were studied in the conscious state. 2/3 of the animals developed a sustained 32-108 per cent increase in cardiac output, and survived 7 days or more. In the other 1/3 of the animals, the cardiac output was lower than the control value and all these animals died within 5 days. There were no differences between the two groups in other parameters examined. Sepsis caused a steady, slight decrease in mean arterial pressure, an increase in heart rate, and leukocytosis. The plasma levels of epinephrine and norepinephrine showed a sustained, significant elevation. The level of thromboxane B2 was high only on the first day of sepsis, and that of plasma renin activity on the first 2 days. Necrosis and edema of jejunal villi were demonstrated histologically in the early period. Hemocultures were positive in only 5 of 11 animals examined, suggesting the predominant role of absorbed toxins. This model simulates human sepsis well and is suitable for the study of pathophysiologic mechanisms in hyperdynamic sepsis.
Nagy
S
S
Institute of Experimental Surgery, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Tárnoky
K
K
Tutsek
L
L
Boros
M
M
Karácsony
G
G
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit; D006439:Hemodynamics / Q000502:physiology*; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D007583:Jejunum / Q000098:blood supply*; D007958:Leukocyte Count; D008297:Male; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D000469:Alkaline Phosphatase; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine