[Determination of the activity of extracts of Echinaceae and Sabal in the treatment of idiopathic megabladder in women].
30 patients (25 to 76 years old), suffering from incontinence (18), pollakiuria (6) and dysuria (6) reveal at the urodynamic investigation (urovideo 2100 and neuromatic 2000M) an idiopathic large hypotonic bladder. 20 have been treated by Echinaceae (84 to 112 mg/a day) and sabalae (78 to 104 mg/a day) extracts (URGENIN: 90 to 120 drops/a day) during a mean time of 77 days. 10 have received 90 to 120 drops/a day of a placebo during a mean time of 52 days. The statistical evaluations have been carried on accord the STUDENT test for small numbers corrected by the FISHER factor. After placebo no modification of the symptomatology and no significant difference in the measures have been registered. After Urgenin: the bladder capacity, the residual urine and the compliance are significantly decreased; the detrusor pressure and the peak flow are significantly increased. The uretral pressure, the closure pressure and the uretral instability show a non-significant decrease. The modifications of the profilometers and sphincter EMG are not significant. In two cases bilateral vesico-renal refluxes have disappeared. The results of the study suggest that the neurotransmission is facilitated and that the smooth muscle fiber is activated by URGENIN. They measure the positive activity of Echinaceae and Sabalae extracts in the treatment of female idiopathic large hypotonic bladders.
Timmermans
L M
LM
Département d'Urologie, CHU-Vesale, Montigny le Tilleul.
Timmermans
L G
LG
D000328:Adult; D000368:Aged; D004338:Drug Combinations; D020900:Echinacea; D005260:Female; D006801:Humans; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics
D004338:Drug Combinations; D010936:Plant Extracts; C067956:urgenin; C030210:echinacin
Mesure de l'activité des extraits d'Echinaceae et de Sabal dans le traitement des mégavessies idiopathiques chez la femme.