Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo.
Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal-treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.
Niu
J Z
JZ
Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield Hospital, Victoria, Australia.
Wang
Y Y
YY
Qiao
M
M
Gowans
E
E
Edwards
P
P
Thyagarajan
S P
SP
Gust
I
I
Locarnini
S
S
D000818:Animals; D004279:DNA, Viral / Q000378:metabolism*; D004372:Ducks / Q000382:microbiology; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D015611:Hepatitis B Virus, Duck / Q000187:drug effects* / Q000254:growth & development; D008099:Liver / Q000382:microbiology; D010946:Plants, Medicinal; D014779:Virus Replication
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens