Molecular neuroanatomy of MAO-A and MAO-B.
A selective, quantitative and high resolution technique (in vitro and in vivo enzyme radioautography) has been used to reveal the tissue distribution and abundance of MAO-A and MAO-B in the central nervous system and peripheral organs in the rat. The in vitro approach was also used to map the enzymes in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found to code for MAO-A and MAO-B respectively and not vice versa.
Saura Marti
J
J
Pharma Research CNS, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Kettler
R
R
Da Prada
M
M
Richards
J G
JG
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009420:Nervous System / Q000033:anatomy & histology / Q000201:enzymology*; D009693:Nucleic Acid Hybridization; D010848:Picolinic Acids / Q000378:metabolism; D051381:Rats; D013844:Thiazoles / Q000378:metabolism
D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; D013844:Thiazoles; C063456:Ro 41-1049; C059303:lazabemide; D008995:Monoamine Oxidase