Monosodium glutamate and tranylcypromine administration in healthy subjects.
The authors administered 400 to 1600 mg of monosodium glutamate and placebo to five healthy males while they were medication-free and again while they were receiving the monoamine oxidase inhibitor tranylcypromine, after having received the drug daily for at least 2 weeks. Monosodium glutamate produced no consistent changes in either blood pressure or heart rate in subjects receiving tranylcypromine. Spontaneous hypertensive episodes were observed in two subjects. These blood pressure increases also occurred with tranylcypromine alone and were unrelated to monosodium glutamate administration. Diet was not violated during these episodes.
Balon
R
R
Department of Psychiatry, Wayne State University.
Pohl
R
R
Yeragani
V K
VK
Berchou
R
R
Gershon
S
S
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005971:Glutamates / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D010919:Placebos; D012970:Sodium Glutamate / Q000494:pharmacology*; D014191:Tranylcypromine / Q000009:adverse effects / Q000494:pharmacology*
D005971:Glutamates; D010919:Placebos; D014191:Tranylcypromine; D012970:Sodium Glutamate