2-Amino-2-oxazolines, III: Synthesis, structure, and preliminary pharmacological evaluation of cycloaddition compounds with unsaturated carboxylic esters.
The reaction of 5-substituted 2-amino-2-oxazolines with unsaturated carboxylic esters yielded 2,3,5,6-tetrahydro- and 2,3-dihydro-7H-oxazolo[3,2-a]pyrimidin-7-ones. The structure of these compounds was established by IR- and NMR-spectra and by X-ray crystallography. They were tested for anti-arrhythmic and hypocholesterolemic activities.
Forfar
I
I
Laboratoire de Chimie Physique, Faculté des Sciences Pharmaceutiques, Université de Bordeaux II, France.
Jarry
C
C
Leger
J M
JM
Carpy
A
A
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
D000889:Anti-Arrhythmia Agents; D000924:Anticholesteremic Agents; D002264:Carboxylic Acids; D004952:Esters; D010080:Oxazoles; D011744:Pyrimidinones