Monotone smoothing with application to dose-response curves and the assessment of synergism.
A spline-based procedure for monotone curve smoothing is proposed and is illustrated by application to dose-response curves. It is then shown how such smoothing can be applied to assess possible synergism or antagonism of two drugs.
Kelly
C
C
Department of Mathematics, University of California, San Diego, La Jolla 92093.
Rice
J
J
D000818:Animals; D001699:Biometry; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008433:Mathematics; D015233:Models, Statistical