title: Right and left ventricular performance after single and double lung transplantation. The Toronto Lung Transplant Group.
abstract: Twelve single lung and nine double lung transplant recipients were studied before transplantation and at 3 months and 1 year after transplantation with serial right and left ventricular radionuclide angiograms. The resting right ventricular ejection fraction increased in the double lung recipients from 31% +/- 5% before transplantation to 43% +/- 11% at 3 months after transplantation (p less than 0.05) and then remained stable to 1 year. The single lung recipients also demonstrated a significant rise in ejection fraction from 25% +/- 11% before transplantation to 36% +/- 12% at 3 months after transplantation. Again, this remained stable to 1 year. The exercise right ventricular ejection fraction also showed a significant posttransplantation rise in the double lung recipients (p less than 0.005) that remained stable to 1 year. In the single lung recipients a trend was seen for a rise in the exercise right ventricular ejection fraction that did not reach statistical significance by 1 year after transplantation. Neither group had a significant change in rest or exercise left ventricular ejection fraction. The systemic blood pressure increased significantly by 1 year after transplantation in both groups. The heart rate increase with exercise at 3 months after transplantation was significantly greater in the single lung group (42 +/- 13 beats/min) than in the double lung group (14 +/- 13 beats/min) (p less than 0.005). These data indicate that a significant improvement in right ventricular function occurs after single and double lung transplantation.
authors.affiliation: Division of Thoracic Surgery, University of Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Carere
authors.forename: G A
authors.initials: GA
authors.lastname: Patterson
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Maurer
authors.forename: R
authors.initials: R
authors.lastname: Grossman
mesh_terms: D000328:Adult; D001794:Blood Pressure; D005080:Exercise Test; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right