Angioimmunoblastic lymphadenopathy with trisomy 3: the cells of the malignant clone are T cells.
A method involving simultaneous demonstration of the immunophenotype and the karyotype was applied to a case of angioimmunoblastic lymphadenopathy (AILD), in which the standard chromosome preparation revealed an aberrant clone with trisomy 3 and additional changes. The aberrant mitoses showed a positive reaction with the monoclonal T-cell antibody Leu 4 (CD3). This new method thus provides definite evidence that the malignant clone with trisomy 3, a characteristic finding in AILD, belongs to the T-cell population. Nevertheless, cytogenetically normal T cells were also found. Moreover, a cell from the same clone was found in the phytohemagglutinin-stimulated blood lymphocytes. This finding demonstrates that AILD may have a leukemic variant.
Schlegelberger
B
B
Department of Human Genetics, Christian Albrecht University, Kiel, West Germany.
Nölle
I
I
Feller
A C
AC
Bauer
E
E
Grote
W
W
D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics* / Q000276:immunology*; D016130:Immunophenotyping; D007621:Karyotyping; D016399:Lymphoma, T-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy