[THe mechanism of the hypotensive effect of glycerin].
In a group of healthy persons, changes in intraocular pressure, indices of hemodynamics of the eye (by the method of rheo-ophthalmography), changes in the heart's rate were studied before and after peroral usage of glycerine in a traditional dose. Authentic fall of intraocular pressure was recorded. Changes in blood filling of the eye proved to be unauthentic. Rheo-ophthalmographic investigations confirmed the leading role of the osmotic factor in the action of glycerine on the eye. It was firstly shown that the slowing down of the heart's rate after the usage of glycerine is likely to be of a neurotropic character. It is recommended to consider the mentioned facts in clinical practice.
Kostenko
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D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents; D004341:Drug Evaluation; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D012016:Reference Values; D013997:Time Factors
D000959:Antihypertensive Agents; D005990:Glycerol
O mekhanizme gipotenzivnogo éffekta glitserina.