Effect of heat inactivation of HIV on specific serum proteins and tumour markers.
The effect on the concentrations of specific serum proteins and tumour markers, of heat-treating samples at 56 degrees C for 30 min to inactivate HIV, was investigated. Statistically significant decreases, that may affect clinical decisions, were observed for alpha-1-antitrypsin, beta-2-microglobulin, IgE, fibrinogen, C1-esterase inhibitor and CA125. Statistical, but not clinically significant, changes were observed for alpha-1-acid glycoprotein, C3, haptoglobin, IgA, IgG, IgM and transferrin. A significant decrease in the alpha-1 band was observed on protein electrophoresis.
Gleeson
M
M
Hunter Immunology Unit, Royal Newcastle Hospital, NSW, Australia.
Herd
L
L
Burns
C
C
D001665:Binding Sites; D014408:Biomarkers, Tumor; D001798:Blood Proteins / Q000378:metabolism*; D003657:Decision Making; D006678:HIV / Q000254:growth & development*; D006358:Hot Temperature; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D014775:Virus Activation
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D009363:Neoplasm Proteins