[The clinical pharmacology and efficacy of the new Soviet calcium antagonist foridon].
A total of 56 patients with coronary heart disease (CHD), angina pectoris of effort, functional classes II-III, were placed under observation. All the patients received 20 mg foridon (F), 20 mg corinfar (C), 80 mg anapriline (A). 24 patients were subjected to the continuous treatment with F (20 mg 4 times a day). The antianginal action of the drug was compared to the blood concentration on days 7, 14, 21, 28, 43 and 57 of the treatment with F. In 14 patients with angina pectoris and in 18 patients with essential hypertension, the efficacy of F and C was cross correlated. It has been demonstrated that F can be successfully used for the treatment of patients with CHD, angina pectoris of effort and (or) essential hypertension. The increase of the single dose of foridon from 20 to 40 mg does not result in the potentiation of its hypotensive effect. F and C provoke the highest rise of exercise tolerance with combined angina pectoris. Continuous concomitant administration of F and C with A leads to the potentiation of the antianginal action.
Kukes
V G
VG
Rumiantsev
A S
AS
Gneushev
E T
ET
Al'perovich
B R
BR
Svetyĭ
L I
LI
Nasyrov
M N
MN
Taratuta
T V
TV
D000787:Angina Pectoris / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D011433:Propranolol / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D011433:Propranolol; D009543:Nifedipine; C045912:ryodipine
Klinicheskaia farmakologiia i éffektivnost' novogo otechestvennogo antagonista kal'tsiia foridona.