Inhalation exposure to respiratory sensitising chemicals down-regulates guinea pig IgE and pulmonary responses.
Inhalation exposure of the guinea pig to the respiratory sensitising chemicals trimellitic anhydride (TMA) or diphenylmethane di-isocyanate down-regulated the IgE antibody response to subsequent systemic challenge with alum-precipitated hapten-protein conjugate. The suppression was isotype and hapten specific, challenge with unrelated hapten-protein conjugate resulting in high-titre IgE and IgGl antibody responses. Preliminary results indicate that the down-regulation of the IgE response to TMA markedly reduced the capacity of the animals to undergo a bronchoconstriction response following challenge with an aerosol of TMA, suggesting that the initial route of exposure may have profound effects upon the development of occupational respiratory allergy.
Dearman
R J
RJ
ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.
Botham
P A
PA
D000280:Administration, Inhalation; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D003485:Cyanates / Q000008:administration & dosage / Q000276:immunology*; D015536:Down-Regulation; D005260:Female; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D017953:Isocyanates; D008168:Lung / Q000276:immunology*; D010796:Phthalic Anhydrides / Q000008:administration & dosage / Q000276:immunology*; D001559:Benzhydryl Compounds
D000941:Antigens; D003485:Cyanates; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D017953:Isocyanates; D010796:Phthalic Anhydrides; C015559:trimellitic anhydride; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds