title: Thin-layer chromatography and densitometry in drug assay: comparison of methods for monitoring valproic acid in plasma.
abstract: A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 micrograms ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Corti
authors.forename: A
authors.initials: A
authors.lastname: Cenni
authors.forename: G
authors.initials: G
authors.lastname: Corbini
authors.forename: E
authors.initials: E
authors.lastname: Dreassi
authors.forename: C
authors.initials: C
authors.lastname: Murratzu
authors.forename: A M
authors.initials: AM
authors.lastname: Caricchia
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D003720:Densitometry / Q000379:methods; D014635:Valproic Acid / Q000097:blood*
chemical_list: D014635:Valproic Acid