title: New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae).
abstract: New antitumor clerodane diterpenes, named casearins A-F, have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). These structures have been completely elucidated by two dimensional nuclear magnetic resonance, circular dichroism spectroscopy, X-ray analysis, and chemical evidences.
authors.affiliation: Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
authors.forename: N
authors.initials: N
authors.lastname: Totsuka
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: Y
authors.initials: Y
authors.lastname: Iitaka
authors.forename: E P
authors.initials: EP
authors.lastname: Schenkel
authors.forename: M
authors.initials: M
authors.lastname: Motidome
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D006224:Cricetinae; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000032:analysis*; D012510:Sarcoma 180 / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes