Ultraviolet-mediated antimycotic activity of alpha-terthienyl on Microsporum cookei.
Alpha-terthienyl (alpha-T) in the presence of UV-A irradiation reduced the growth rate of Microsporum cookei. In the dark, alpha-T accumulated in small diffuse vacuoles within the hyphae. After UV-A treatment, alpha-T caused damage to the membranes of the nucleus, mitochondria and endoplasmic reticulum. Plasmolytic and autolytic changes occurred resulting in plasma membrane breakage and cell wall aberrations. UV-A activated alpha-T would appear to target membrane proteins.
Mares
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Institute of Botany, University of Ferrara, Italy.
Fasulo
M P
MP
Bruni
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A
D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008864:Microsporum / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D013876:Thiophenes / Q000494:pharmacology*; D014466:Ultraviolet Rays
D013876:Thiophenes; C019101:alpha-terthienyl