Common epileptic pathway in amygdaloid bicuculline and electrical kindling demonstrated by transferability.
The transferability between amygdaloid bicuculline kindling and electrical kindling was studied in rats. Electrically kindled animals exhibited stage 5 generalized seizures on the first injection of bicuculline, in contrast to the 3-7 injections required in controls. Similarly, bicuculline-kindled animals reached stage 5 after significantly fewer electrical stimulations than controls; two-thirds of the bicuculline-kindled animals began in stage 1 but skipped stages 3 and 4 on their way to stage 5. These data indicate that a common generalization mechanism exists in both types of kindling, but the process of progression from local seizure to generalized seizure may be immature in bicuculline kindling.
Uemura
S
S
Department of Psychiatry, Miyazaki-Shinkeika Saga Hospital, Kyoto, Japan.
Kimura
H
H
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D001640:Bicuculline