Bright light does not alter muscarinic receptor binding parameters.
Seasonal Affective Disorders (SADs) are disorders of mood characterized by recurrent episodes of illness with a fixed relationship to season. Winter depression is characterized by recurrent onset of depression in the fall or winter followed by spontaneous recovery in the spring. This syndrome is responsive to treatment with bright light. The pathophysiology of depressive disorders may involve central muscarinic mechanisms. This possibility led to a series of physiological studies. The authors now report that contrary to expectation, treatment with bright light did not decrease the density of muscarinic receptors in either the hypothalamus or striatum.
Giroux
M L
ML
Medical Scientist Training Program, Ohio State University, College of Medicine.
Malatynska
E
E
Dilsaver
S C
SC
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008027:Light; D008029:Lighting; D008297:Male; D019964:Mood Disorders / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012621:Seasons
D011976:Receptors, Muscarinic