Triiodothyronine (T3) increases cisplatin nephrotoxicity in young and adult rats.
The influence of pretreatment with triiodothyronine (T3) on cisplatin (CP)-induced nephrotoxicity was investigated in 10- and 55-day-old rats. Triiodothyronine pretreatment enhanced CP proteinuria in young and adult rats, and increased blood urea nitrogen concentration in 55-day-old rats. As T3 decreased Pt concentrations in renal tissue, the enhanced nephrotoxicity of CP by T3 must have another mechanism. Enhanced CP nephrotoxicity is discussed in connection with an increase of glutathione concentration obtained in renal tissue as a consequence of T3 pretreatment.
Appenroth
D
D
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, GDR.
Gambaryan
S
S
Bakhteeva
V
V
Winnefeld
K
K
Schröter
H
H
Gerhardt
S
S
Bräunlich
H
H
D000375:Aging / Q000378:metabolism / Q000502:physiology / Q000652:urine; D000818:Animals; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000493:pharmacokinetics / Q000633:toxicity*; D004357:Drug Synergism; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D019803:Glutathione Disulfide; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology*; D014556:Urine
D014284:Triiodothyronine; D005978:Glutathione; D002945:Cisplatin; D019803:Glutathione Disulfide