Blood-brain barrier disruption following CPR in piglets.
We studied blood-brain barrier (BBB) integrity in immature piglets during the following cardiopulmonary resuscitation (CPR). As in our previous work in the dog, there was no disruption during CPR after eight minutes of cardiac arrest, or immediately following resuscitation using a small molecule, alpha-aminoisobutyric acid. However, unlike the dog, where the BBB remained intact, we found delayed disruption of the BBB four hours after resuscitation. Young animals may be more prone to a delayed increase in BBB permeability after cardiac arrest and CPR.
Schleien
C L
CL
Johns Hopkins Medical Institutions, Department of Anesthesiology/Critical Care Medicine, Baltimore, Maryland.
Koehler
R C
RC
Shaffner
D H
DH
Traystman
R J
RJ
D000621:Aminoisobutyric Acids / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002199:Capillary Permeability; D004554:Electric Countershock; D012151:Resuscitation; D013552:Swine
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid