Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.
Infection of the human lymphocyte CEM cell line with the HIV-1 (human immunodeficiency virus-1, LAV-1 strain) results in cell death. A fluoroquinolone antibiotic, ofloxacin, protected the infected cells from HIV-1-mediated cytolysis. Other fluoroquinolones, e.g. ciprofloxacin, norfloxacin, and enoxacin, also protected the infected cells from HIV-1-mediated cytolysis. The d-isomer of ofloxacin (DR-3354) was about 50-fold less effective than the l-isomer (DR-3355). Almost none of the rescued cells had detectable HIV-antigens and they could be maintained for long periods in vitro without drugs.
Nozaki-Renard
J
J
Department of Microbiology, Tokyo Medical College, Japan.
Iino
T
T
Sato
Y
Y
Marumoto
Y
Y
Ohta
G
G
Furusawa
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D015365:Enoxacin / Q000494:pharmacology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D009643:Norfloxacin / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*
D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin