Superoxide dismutase in psoriasis, squamous cell carcinoma and basal cell epithelioma: an immunohistochemical study.
Monoclonal antibodies against human Cu,Zn-superoxide dismutase (SOD) and Mn-SOD were used to stain frozen sections of normal and abnormal human skin. In normal human epidermis, the Cu,Zn-SOD antibody almost exclusively stained the basal cells. Mn-SOD antibody weakly stained the whole of the epidermis but more predominantly the basal cell layer. In psoriasis, Cu,Zn-SOD antibody mainly stained the basal cells of the lowest parts of the elongated rete ridges. Basal cells corresponding to the tip of the dermal papillae were weakly stained. Mn-SOD staining was considerably decreased in the psoriatic epidermis. In squamous cell carcinoma, staining with both Cu,Zn-SOD and Mn-SOD antibodies was decreased, and single cells positive for Cu,Zn-SOD were scattered throughout the tumour nests. In basal cell epithelioma, Cu,Zn-SOD staining was intense and diffusely distributed throughout the tumour nests, while Mn-SOD staining was absent.
Kobayashi
T
T
Department of Dermatology, Asahikawa Medical College, Japan.
Matsumoto
M
M
Iizuka
H
H
Suzuki
K
K
Taniguchi
N
N
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002280:Basal Cell Carcinoma / Q000201:enzymology*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D004817:Epidermis / Q000201:enzymology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000201:enzymology*; D012878:Skin Neoplasms / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000032:analysis* / Q000097:blood / Q000276:immunology
D000911:Antibodies, Monoclonal; D013482:Superoxide Dismutase