[Demonstration of BCR-ABL rearrangement in a patient with apparently Ph-negative chronic myeloid leukemia of 15 years' duration].
We have studied the haematologic cytogenetic and molecular features in a patient with Ph negative CML of 15 years of evolution. Cytogenetic analysis showed a normal karyotype in different studies. Molecular study showed rearrangement within bcr region. This gene fusion between c-abl oncogene and bcr gene is typical of the Ph chromosome. These results show the usefulness of performing a molecular study in those patients with Ph negative CML.
Valiente
A
A
Departamento de Genética, Hematología, Fundación Jiménez Díaz, Madrid.
Outeriño
J
J
Martín Calderín
F
F
Benítez
J
J
D000328:Adult; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis / Q000235:genetics*; D009857:Oncogenes; D010677:Philadelphia Chromosome
D004273:DNA, Neoplasm; D016044:Fusion Proteins, bcr-abl
Demostración de reordenamiento BCR-ABL en una paciente con leucemia mieloide crónica aparentemente Ph-negativa de 15 años de evolución.