title: [Study of toxicity and antineoplastic activity of 14-substituted derivatives of rubomycin and carminomycin].
abstract: Toxicity and antitumor activity of five derivatives of rubomycin and carminomycin were studied in animals. The derivatives were prepared by modification of the methyl C-14 group. These were the following: 14-chlorrubomycin, 14-chlorcarminomycin, 14-salicyloyloxyrubomycin, 14-salicyloyloxycarminomycin and 14-quinaldinoyloxyrubomycin. The chemotherapeutic study revealed that, in their activity, all the compounds were inferior to the starting antibiotics. Unlike the other derivatives, 14-chlorcarminomycin induced a significant inhibition of leukemia P-388 development (the average lifespan of the mice amounted to 165 per cent as compared to the control). However, in the magnitude of its effect, the derivative was inferior to carminomycin.
authors.forename: L A
authors.initials: LA
authors.lastname: Ul'ianova
authors.forename: O I
authors.initials: OI
authors.lastname: Iudina
authors.forename: V E
authors.initials: VE
authors.lastname: Tarasova
authors.forename: N G
authors.initials: NG
authors.lastname: Shepelevtseva
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: L S
authors.initials: LS
authors.lastname: Povarov
authors.forename: L E
authors.initials: LE
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D002360:Carubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000633:toxicity; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*
chemical_list: C064079:14-salicyloyldaunorubicin; C064080:14-salicyloylcarubicin; C064078:14-chlorodaunorubicin; C064081:14-quinaldinoyloxydaunorubicin; C064077:14-chlorocarubicin; D002360:Carubicin; D003630:Daunorubicin
vernacular_title: Izuchenie toksichnosti i protivoopukholevoĭ aktivnosti 14-zameshchennykh proizvodnykh rubomitsina i karminomitsina.