[Multifactor analysis of the combined use of an antibiotic and a low molecular weight immunomodulator of microbial origin in experimental plague infection].
Multifactorial analysis of the combined effect of rifampicin and a low molecular immunomodulator of microbial origin in experimental plague infection was performed. Synergism of the antibiotic used in the subtherapeutic doses and the immunomodulator was shown. By the results of the study polynomial statistic models of the second order describing the survival rate and average life-span of the experimental animals were developed and nomographs (equal level curves) were plotted for rapid estimating the therapy quantitative parameters. Optimization of the combined use of rifampicin and the immunomodulator on the basis of the multifactorial analysis was achieved.
Nikitin
A V
AV
Makarovskaia
L N
LN
Fomina
I P
IP
Ivanitskaia
L P
LP
Popova
G O
GO
Vinidchenko
N N
NN
Korganov
Ia N
IaN
Kudinova
M K
MK
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000096:biosynthesis; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005163:Factor Analysis, Statistical; D008017:Life Expectancy; D051379:Mice; D015233:Models, Statistical; D008970:Molecular Weight; D010930:Plague / Q000188:drug therapy* / Q000401:mortality; D012293:Rifampin / Q000008:administration & dosage*; D015996:Survival Rate
D000276:Adjuvants, Immunologic; D012293:Rifampin
Mnogofaktornyĭ analiz kombinirovannogo primeneniia antibiotika i nizkomolekuliarnogo immunomoduliatora mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnĭ infektsii.