title: An air quality data analysis system for interrelating effects, standards, and needed source reductions: Part 11. A lognormal model relating human lung function decrease to O3 exposure.
abstract: Forced expiratory volume in 1 second (FEV1) was measured in 21 men exercising while exposed to four O3 concentrations (0.0, 0.08, 0.10, and 0.12 ppm). A lognormal multiple linear regression model was fitted to their mean FEV1 measurements to predict FEV1 percent decrease as a function of O3 concentration and exposure duration. The exercise level used was probably comparable to heavy manual labor. The longest O3 exposure studied was 6 h. Extrapolating cautiously to an 8-h workday of heavy manual labor, the model predicts that O3 concentrations of 0.08, 0.10, and 0.12 ppm would decrease FEV1 by 9, 15, and 20 percent, respectively.
authors.affiliation: U.S. Environmental Protection Agency, Research Triangle Park, North Carolina.
authors.forename: R I
authors.initials: RI
authors.lastname: Larsen
authors.forename: W F
authors.initials: WF
authors.lastname: McDonnell
authors.forename: D H
authors.initials: DH
authors.lastname: Horstman
authors.forename: L J
authors.initials: LJ
authors.lastname: Folinsbee
mesh_terms: D000328:Adult; D005541:Forced Expiratory Volume; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D016011:Normal Distribution; D010126:Ozone / Q000633:toxicity*; D005082:Physical Exertion; D012044:Regression Analysis
chemical_list: D010126:Ozone