Paramagnetic oil emulsions as oral magnetic resonance imaging contrast agents.
The combination of a paramagnetic agent with an oil emulsion can uniformly enhance the small bowel. We discovered that the entire small bowel becomes homogeneously brighter than its surroundings when imaged with all commonly utilized pulse sequences. We have tried various combinations of ferric ammonium citrate, ferrous sulfate, gadolinium-DPTA and corn oil, olive oil and peanut oil. All paramagnetic oil emulsions tested were uniformly distributed throughout the small bowel, but the enhancement effect is much stronger with the ferric ammonium citrate and gadolinium-DPTA oil emulsions. We have also developed a mixture of Geritol, corn oil, ice cream and milk, which uniformly coats the small bowel wall, has good enhancement effect, tastes good, and is nutritious. With this dietary contrast, retroperitoneal structures including the pancreas can be well delineated. We conclude that the combination of a paramagnetic agent with an oil emulsion can work as a safe and effective magnetic resonance imaging (MRI) oral contrast agent with high patient acceptance.
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Department of Radiology, University of Florida College of Medicine, Gainesville 82610.
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D000818:Animals; D045424:Complex Mixtures; D003287:Contrast Media / Q000138:chemical synthesis; D003314:Corn Oil; D004655:Emulsions / Q000138:chemical synthesis; D005260:Female; D005290:Ferric Compounds; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007054:Ice Cream; D007089:Image Enhancement; D007421:Intestine, Small / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008892:Milk; D009942:Organometallic Compounds; D004369:Pentetic Acid; D010938:Plant Oils; D013649:Taste; D014803:Vitamin B Complex
D045424:Complex Mixtures; D003287:Contrast Media; D004655:Emulsions; D005290:Ferric Compounds; D009942:Organometallic Compounds; D010938:Plant Oils; D014803:Vitamin B Complex; D004369:Pentetic Acid; D003314:Corn Oil; C067316:Geritol; D005682:Gadolinium; D019786:Gadolinium DTPA