Bacteria-phagocyte interactions: emerging tactics in an ancient rivalry.
Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanisms, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular level, both the recognition of specific bacterial virulence determinants and their effects at specific sites in the phagocyte are also being identified. Knowledge of these interactions may permit the use of immunomodulators either to neutralize these virulence determinants or to enhance the bactericidal capabilities of the phagocyte.
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Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
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D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000503:physiopathology; D018407:Bacterial Physiological Phenomena; D002634:Chemotaxis, Leukocyte; D003165:Complement System Proteins / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D009895:Opsonin Proteins / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis; D010588:Phagosomes / Q000201:enzymology; D014774:Virulence
D016207:Cytokines; D009895:Opsonin Proteins; D003165:Complement System Proteins; D010100:Oxygen