title: [Three cases of oligomeganephronia].
abstract: Three cases of bilateral renal hypoplasia with oligomeganephronia are reported. In all three patients urine abnormalities were pointed out by annual urine screening for school-children and they showed mild or moderate deterioration of renal function. One patient had repeated episodes of urinary tract infection, and bilateral vesico-ureteral reflux (grade III) was found by the voiding cystourethrography. Light microscopic findings of renal biopsy specimens were similar in three cases; significant hypertrophy of the glomerulus and tubulus; mild mesangial expansion, and interstitial changes. Further histological examination which was done in one case showed widespread foot process fusion, mesangial interposition and membrane-like structures by electron microscopy, and mesangial IgA deposition by immunofluorescence. Three was no alteration in immuno-staining pattern for basement membrane components, including type VI and V collagens, laminin and fibronectin, in the glomeruli.
authors.affiliation: Department of Pediatrics, Kinki University School of Medicine, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsubara
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: N
authors.initials: N
authors.lastname: Akano
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Takemura
authors.forename: S
authors.initials: S
authors.lastname: Maki
mesh_terms: D000293:Adolescent; D003182:Complement C5 / Q000378:metabolism; D050776:Complement C5b; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000002:abnormalities* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008853:Microscopy
chemical_list: D003182:Complement C5; D007070:Immunoglobulin A; D050776:Complement C5b