title: On the repair of thymine and thymidine bromohydrins: a possible new model for the damage and repair of nucleic acids.
abstract: Bromohydrins (2, 3, 4, and 5), oxidatively damaged products of thymine bases, were repaired on exposure to sunlight, heat, and/or some reagents to regenerate the thymine bases. A radical mechanism is proposed for the repair reaction with sunlight and heat. A hypothesis concerning the biological significance of thymidine in deoxyribonucleic acid is presented.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Harayama
authors.forename: R
authors.initials: R
authors.lastname: Yanada
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: F
authors.initials: F
authors.lastname: Yoneda
mesh_terms: D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D008956:Models, Chemical; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: C054175:thymidine bromohydrin; C069843:thymine bromohydrin; D013941:Thymine; D013936:Thymidine