Pyrrolobenzodiazepine and related systems. I. Synthesis and pharmacological evaluation of new 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives.
Some new 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives substituted at the 5 position have been synthesized and tested to evaluate their antidepressant and neuropsychopharmacological activities. The antinociceptic action of these compounds has been also assayed. The introduction of an ethoxycarbonyl group at the 4 position generally decreased the antidepressant effect.
Massa
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Dipartimento Studi Farmaceutici, Facoltà di Farmacia, Università Di Roma La Sapienza.
Artico
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M
Mai
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Corelli
F
F
Pantaleoni
G C
GC
Giorgi
R
R
Ottaviani
D
D
Cagnotto
A
A
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central; D011597:Psychomotor Performance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011955:Receptors, Drug / Q000378:metabolism
D000700:Analgesics; D000927:Anticonvulsants; D000928:Antidepressive Agents; D009125:Muscle Relaxants, Central; D011619:Psychotropic Drugs; D011955:Receptors, Drug