[Changes in electric activity of neurons of dorsal raphe nuclei in the development of generator of pathologically enhanced excitation in the nociceptive system].
In the experiments on rats it was proved by the method of extracellular registration of impulse neuron activity of dorsal raphe nucleus, that the formation of generator of pathologically enhanced excitation (GPEE) in nociceptive structures of spinal brain underlying the pain syndrome of spinal origin, results in a change of electric neuron activity of dorsal raphe nucleus. These changes are manifested by growing number of background nucleus neurons, the increase of middle frequency of discharges, and assuming pack character of impulse activity. These changes are greater marked in a ventral nucleus part, than in a dorsal one, which is evident of the activation of this antinociceptive system structure. The changes of electric activity of dorsal raphe neurons are stable for a long time after GPEE is formed in nociceptive system, and participate in suppression of GPEE and corresponding pain syndrome.
Kryzhanovskiĭ
G N
GN
Igon'kina
S I
SI
Trubetskaia
V V
VV
D000818:Animals; D004594:Electrophysiology; D008297:Male; D009474:Neurons / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011903:Raphe Nuclei / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
Izmeneniia élektricheskoĭ aktivnosti neĭronov dorsal'nogo iadra shva pri razvitii generatora patologicheski usilennogo vozbuzhdeniia v notsitseptivnoĭ sisteme.