[Autologous marrow transplantation purged by heat--a case report. Niigata University BMT Team].
We presented here a case with ALL transplanted with autologous marrow cells cryopreserved after heat treatment. Bone marrow cells from a 17-year-old female patient in first complete remission were cryopreserved after treatment with heat (42 degrees C, 60 min) and interferon-alpha. Three and a half years later, at her 4th remission, she was treated with busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg) followed by autologous marrow infusion. The hemopoietic recovery after marrow infusion was prompt except in thrombopoietic lineage. She was doing well without limitation until leukemic relapse after 6 months. From this experience, marrow cells treated with heat and cryopreservation still include multipotent hemopoietic stem cells.
Kishi
K
K
First Department of Internal Medicine, Niigata University School of Medecine.
Higuchi
W
W
Moriyama
Y
Y
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D014182:Transplantation, Autologous