Nabumetone. Evidence for the lack of enterohepatic circulation of the active metabolite 6-MNA in humans.
Brett
M A
MA
Clinical Pharmacology Research Institute, Beecham-Wülfing GmbH & Co KG, Neuss, Federal Republic of Germany.
Buscher
G
G
Ellrich
E
E
Greb
W H
WH
Kurth
H J
HJ
Rülander
G
G
Schmerenbeck
B
B
Haddock
R E
RE
Thawley
A R
AR
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism* / Q000494:pharmacology; D002074:Butanones / Q000378:metabolism* / Q000494:pharmacology; D002792:Cholestyramine Resin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D004764:Enterohepatic Circulation / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D008297:Male; D000077430:Nabumetone; D009280:Naphthaleneacetic Acids / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D009280:Naphthaleneacetic Acids; D002792:Cholestyramine Resin; C044612:6-methoxy-2-naphthylacetic acid; D000077430:Nabumetone