Single-dose subcutaneous iodine-131-iodohippurate for determination of renal plasma flow.
Subcutaneous administration of a single dose of 131I-iodohippurate was used for determination of renal plasma flow (RPF) in 20 subjects during water diuresis. Slow release of tracer (200 microCi) permitted serial clearance measurements over 5 hr that were compared to standard, constant infusion, PAH clearance (mean 379.5 +/- 34.9 ml/min/1.73 m2, range 50.9 to 696.3 ml/min/1.73 m2). RPF(Isotope) was 424.9 +/- 30.3 ml/min/1.73 m2 (range 144.4 to 746.5 ml/min/1.73 m2) and highly correlated with RPFPAH (r = 0.883, p less than 0.0001). This technique permits prolonged studies of renal plasma flow under steady-state conditions without constant infusion.
Grant
M E
ME
Department of Medicine, University of Kansas Medical Center, Kansas City.
Herron
K G
KG
MacDougall
M L
ML
Preston
D F
DF
Moore
W V
WV
Wiegmann
T B
TB
D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology / Q000628:therapy; D004231:Diuresis / Q000502:physiology; D006801:Humans; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000008:administration & dosage; D012079:Renal Circulation / Q000502:physiology*
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid