title: Effects of auranofin on endothelium dependent contractions in isolated rat aorta.
abstract: Auranofin (10(-6) and 10(-5)M) reduces the acetylcholine induced relaxation in the isolated rat aorta. Contractions induced by phenylephrine and 5-hydroxytryptamine are enhanced by auranofin 10(-6)M only when endothelium is present. At higher concentration (10(-5)M), it antagonizes the agonist-induced contractions either in the presence or absence of endothelium.
authors.affiliation: Laboratory of Pharmacology, Erasmus Hospital, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Fontaine
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Fang
authors.forename: G
authors.initials: G
authors.lastname: Berkenboom
authors.forename: J P
authors.initials: JP
authors.lastname: Famaey
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001310:Auranofin / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
chemical_list: D010656:Phenylephrine; D012701:Serotonin; D001310:Auranofin; D000109:Acetylcholine