[Immunohistochemical detection of chromogranin A and morphometric findings in pancreatic nesidioblastosis in children].
The histologic features and morphometric data of the endocrine pancreas (surgical specimens) of 12 infants suffering from persistent hyperinsulinemic hypoglycemia are reported. In 3 cases, a focal nesidioblastosis, in another 3 cases, a diffuse nesidioblastosis were observed. 2 infants demonstrate B-cell adenomata and 4 adenomata combined with a diffuse nesidioblastosis. In respect to volume density of the endocrine pancreas and diameter of the islets, there are no differences between cases with diffuse nesidioblastosis and age-matched controls. Structural changes of the endocrine pancreas in cases with nesidioblastosis are detectable by their chromogranin-A-immunoreactivity. Further investigations are necessary to clarify if there are disturbances in the relationships between chromogranin A and peptide hormones additionally to structural changes in the pancreas.
Kunz
J
J
Institut für Pathologie des Bezirkskrankenhauses Potsdam, Deutschland.
Haberland
H
H
Schmidt
A
A
Amendt
P
P
D000236:Adenoma / Q000150:complications / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis* / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010179:Pancreas / Q000473:pathology; D010182:Pancreatic Diseases / Q000150:complications / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins
Immunhistochemischer Chromogranin A-Nachweis und morphometrische Befunde bei frühkindlicher Nesidioblastose.