Dexamethasone does not influence infarct size but causes haemorrhage in baboons with cerebral infarcts.
15 baboons with permanent occlusion of the left MCA were randomly treated with dexamethasone (n = 8; 1 mg/kg day) or 0.9% NaCl (n = 5). Dexamethasone did not reduce the resulting infarct size. However, steroid treated animals had more brain tissue affected by haemorrhage, although this did not seem to affect survival.
Hartmann
A
A
Neurologische Universitätsklinik Bonn, Federal Republic of Germany.
Ebhardt
G
G
Rommel
T
T
Meuer
A
A
D000818:Animals; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology*; D010215:Papio
D003907:Dexamethasone