title: [The effect of acute ACTH1-24 loading on the steroid hormone and prolactin content of the blood serum in women with hyperprolactinemia and hyperandrogenism].
abstract: Adrenocortical and ovarian function in women with hyperprolactinemia and hyperandrogenism was evaluated using the functional ACTH1-24-test (with syncorpin--25 U/ml), a radioimmunoassay was used to estimate the levels of II-OCS, androgens, progestins, estrogens and prolactin in the blood serum of 29 women with primary prolactinemic hypogonadism (HG), in 15--with hyperandrogenic ovarian dysfunction, in 27--with the hypothalamic syndrome of neuro-endocrine type, and in 13 healthy women. Marked interference of a clinical picture was found in patients with disturbed menstrual and reproductive function with relation to the presence of galactorrhea and hirsutism. All the examinees retained glucocorticoid function. Patients with hyperprolactinemia demonstrated an increase in the basal concentration of the ovarian androgen androstenedione in the absence of its response to ACTH. The level of 17-oxyprogesterone in them was decreased. A paradoxical response of prolactin to syncorpin was observed in patients with microprolactinemia, the syndrome of the "empty" Turkish saddle and functional type of HG.
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: G A
authors.initials: GA
authors.lastname: Mel'nichenko
authors.forename: T D
authors.initials: TD
authors.lastname: Bol'shakova
authors.forename: A F
authors.initials: AF
authors.lastname: Buniatian
authors.forename: E P
authors.initials: EP
authors.lastname: Gitel'
authors.forename: D E
authors.initials: DE
authors.lastname: Shilin
authors.forename: A A
authors.initials: AA
authors.lastname: Nosova
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D003366:Cosyntropin; D005260:Female; D005687:Galactorrhea / Q000097:blood; D006628:Hirsutism / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D007006:Hypogonadism / Q000097:blood; D007247:Infertility, Female / Q000097:blood; D008599:Menstruation Disturbances / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood; D011388:Prolactin / Q000097:blood / Q000187:drug effects*
chemical_list: D000728:Androgens; D003366:Cosyntropin; D011388:Prolactin
vernacular_title: Vliianie ostroĭ nagruzki AKTG1-24 na soderzhanie steroidnykh gormonov i prolaktina v syvorotke krovi zhenshchin s giperprolaktinemieĭ i giperandrogenieĭ.