title: Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity.
abstract: Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor (protein kinase C) may be involved in the increased renal vascular resistance associated with cyclosporine A-induced nephrotoxicity.
authors.affiliation: Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
authors.forename: P
authors.initials: P
authors.lastname: Nambi
authors.forename: M
authors.initials: M
authors.lastname: Pullen
authors.forename: H L
authors.initials: HL
authors.lastname: Wu
authors.forename: D P
authors.initials: DP
authors.lastname: Brooks
mesh_terms: D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003524:Cyclosporins / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000378:metabolism*; D014655:Vascular Resistance
chemical_list: D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003524:Cyclosporins; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D011493:Protein Kinase C