Pindolol inhibits the development of hypoxic pulmonary vasoconstriction.
We examined the effects of beta-adrenoceptor antagonists, propranolol and pindolol, on hypoxic pulmonary vasoconstriction using isolated, blood-perfused dog lung lobes. Pindolol markedly inhibited the development of hypoxic pulmonary vasoconstriction, whereas propranolol had no effect. The different role of the drugs on hypoxic pulmonary vasoconstriction is discussed.
Takashio
T
T
First Department of Internal Medicine, Asahikawa Medical College, Hokkaido, Japan.
Yamashita
H
H
Onodera
S
S
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D010869:Pindolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
D011433:Propranolol; D010869:Pindolol