Lidocaine absorption and metabolism after oropharyngeal application in young and young-elderly adults.
The purpose of this study was to evaluate the effect of age on lidocaine absorption and metabolism after application to the oropharynx and vocal cords in a manner similar to preparation for flexible fiberoptic bronchoscopy. Five healthy volunteers were studied in each of two age groups: from 25 to 37 and 60 to 68 years of age. Each volunteer had a total of lidocaine 300 mg administered as a gargle, gel, or directly to the vocal cords. Blood samples and expectorant were collected to determine concentrations of lidocaine and its metabolites, monoethylglycinxylidide (MEGX) and glycinxylidide (GX). No differences in peak plasma lidocaine concentrations, 2.09 +/- 1.28 mumol/L (1 microgram/mL = 4.27 mumol/L) in young subjects, and 2.35 +/- 0.85 mumol/L in young-elderly subjects, or lidocaine AUC were seen between the two age groups. Lidocaine recovered in expectorant ranged from 96 to 168 mg. This study suggests that, over the age range studied, increased age does not impair lidocaine absorption from the oropharynx or lidocaine metabolism when topical lidocaine is used during flexible fiberoptic bronchoscopy.
Watson
W A
WA
University of Missouri-Kansas City.
Sands
M F
MF
Barlow
J C
JC
Lener
M E
ME
Wilton
J H
JH
D000042:Absorption; D000328:Adult; D000367:Age Factors; D000368:Aged; D004304:Dosage Forms; D005782:Gels; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D009960:Oropharynx / Q000378:metabolism; D013183:Sputum / Q000737:chemistry; D014827:Vocal Cords / Q000378:metabolism
D004304:Dosage Forms; D005782:Gels; D008012:Lidocaine; C001306:glycinexylidide; C001173:monoethylglycinexylidide