Alterations in the composition of human stratum corneum lipids induced by inflammation.
Changes in the composition of human stratum corneum lipids (SCL) were studied at various times after an induced inflammatory reaction. Three kinds of injury were inflicted: 3 MED of ultraviolet radiation, 3 MED of solar radiation or 30 strippings of the horny layer with plastic tape. The SCL were evaluated qualitatively and quantitatively at short intervals. Marked changes in the SCL were detected between the 9th and the 11th day. With all 3 insults, the SCL increased quantitatively and showed a more polar pattern, i.e. a decrease in neutral fractions and an increase in the polar ones. These changes were synchronous with the marked shedding which occurs between the 9th and the 11th day. These findings have implications for the role of lipids in stratum corneum cohesiveness.
Chatenay
F
F
Laboratory de Recherche, Aulnay Sous Bois, France.
Corcuff
P
P
Saint-Leger
D
D
Leveque
J L
JL
D000293:Adolescent; D000328:Adult; D004817:Epidermis / Q000737:chemistry* / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000378:metabolism*; D012867:Skin / Q000293:injuries; D013261:Sterols / Q000032:analysis; D013472:Sunlight / Q000009:adverse effects; D013997:Time Factors; D014280:Triglycerides / Q000032:analysis; D014466:Ultraviolet Rays / Q000009:adverse effects
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D013261:Sterols; D014280:Triglycerides