[In vivo activation of the kallikrein-kinin system of rats by human Hageman factor fragments].
Administration of factor XIIf prepared from human plasma activated the kallikrein-kinin system in vivo. In rats there was a decrease in kallikreinogen as well as a short decrease of the mean arterial blood pressure. The results described are of importance for the research of pathogenesis of shock.
Taucher
M
M
Institut für Pathologische Biochemie, Medizinischen Hochschule Carl Gustav Carus Dresden.
Herzmann
K
K
Kühne
H
H
Scheuch
D W
DW
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005174:Factor XII / Q000494:pharmacology*; D006801:Humans; D016234:Kallikrein-Kinin System / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000209:etiology*
D010446:Peptide Fragments; D005174:Factor XII
In-vivo-Aktivierung des Kallikrein-Kinin-Systems der Ratte mit humanem Hageman-Faktor-Fragment.