title: [A comparative study of the antiheparin activity and acute toxicity of stellins].
abstract: The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.
authors.forename: L V
authors.initials: LV
authors.lastname: Grigorova
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Rozkin
authors.forename: V K
authors.initials: VK
authors.lastname: Rybin
authors.forename: V S
authors.initials: VS
authors.lastname: Efimov
authors.forename: N V
authors.initials: NV
authors.lastname: Makarov
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D029941:Fish Proteins; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D011479:Protamines / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
chemical_list: D029941:Fish Proteins; D006494:Heparin Antagonists; D011479:Protamines; C029829:protamine B, Acipenser gueldenstaedtii; C025098:Stellin; C029828:protamine A, Acipenser stellatus
vernacular_title: Sravnitel'noe issledovanie antigeparinovoĭ aktivnosti i ostroĭ toksichnosti stellinov.