The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury.
The effects of SA3443, a novel cyclic disulfide compound, on acute liver injuries induced by carbon tetrachloride (CCl4), D-galactosamine and DL-ethionine were studied in rats or mice. SA3443 (100-300 mg/kg, p.o.) significantly suppressed the increases of serum transaminase activity and liver triglyceride content in the CCl4 or DL-ethionine-induced model. Furthermore, SA3443 (300 mg/kg, p.o.) clearly reduced the formation of hepatic lipid peroxide in CCl4-treated rats. These results indicate that SA3443 protects the liver against acute liver injury.
Ishida
N
N
Central Research Laboratories, Santen Pharmaceutical Co., Ltd., Osaka, Japan.
Nakata
K
K
Tanaka
M
M
Takase
K
K
Mita
S
S
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001392:Azocines / Q000494:pharmacology*; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D004220:Disulfides / Q000494:pharmacology*; D005001:Ethionine; D005688:Galactosamine; D008054:Lipid Peroxides / Q000378:metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D001392:Azocines; D004220:Disulfides; D008054:Lipid Peroxides; D014280:Triglycerides; C069788:SA 3443; D005688:Galactosamine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005001:Ethionine