title: Epidermal Langerhans' cells in elderly patients with decubital ulcers.
abstract: Langerhans' cells in the sacral epidermis 8-10 cm from the lesion of elderly patients (mean age 74 years) with decubital ulcers were studied ultrastructurally and compared with the patients' own normal epidermis from the upper leg, with age-matched normal controls, and with young normal controls (mean age 43 years). High percentages of Langerhans' cells (ranging between 30 and 50%) without dendrites were found in patient epidermis from the sacral region near the lesion and similar percentages in normal skin from the patients' upper leg. In both elderly and young controls, Langerhans' cells without dendrites found in the epidermis of the upper leg were fewer, ranging between 13 and 33%. The density of Langerhans' cells in adjacent sites of the same epidermis was non-homogeneous, being in the range of 0.56-1.19% in patient sacral epidermis, 0.69-1.31% in patient normal leg epidermis, 0.63-4.17% in leg epidermis of the elderly controls, and 0.63-3.94% in leg epidermis of the young controls. The majority of the Langerhans' cells in both patients and controls were located near the basal cell layer and in the mid-epidermis. The percentage of Langerhans' cells found in patient sacral epidermis (0.84 +/- 0.08%) and in their leg epidermis (0.87 +/- 0.15%) was significantly lower than in the elderly controls (1.91 +/- 0.30%) and young controls (1.84 +/- 0.24%). The low percentage of Langerhans' cells in the epidermis of patients with decubital ulcers may affect the healing process of the lesions.
authors.affiliation: Unit of Electron Microscopy, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Kohn
authors.forename: D
authors.initials: D
authors.lastname: Kohn
authors.forename: D
authors.initials: D
authors.lastname: Schiller
mesh_terms: D000328:Adult; D000368:Aged; D004817:Epidermis / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000473:pathology*; D012016:Reference Values