title: [Preparation of derivatives of the aldehydic functions of gossypol].
abstract: Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.
authors.affiliation: Laboratoire de Chimie des Substances thérapeutiques naturelles, UA CNRS n. 496, Centre d'Etudes pharmaceutiques, Châtenay-Malabry.
authors.forename: N
authors.initials: N
authors.lastname: Kunesch
authors.forename: M P
authors.initials: MP
authors.lastname: Barbier
authors.forename: A
authors.initials: A
authors.lastname: Dalkafouki
authors.forename: J E
authors.initials: JE
authors.lastname: Poisson
mesh_terms: D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism; D012545:Schiff Bases / Q000138:chemical synthesis
chemical_list: D011073:Polyamines; D012545:Schiff Bases; D006072:Gossypol
vernacular_title: Préparation de dérivés de la fonction aldéhyde du gossypol.