title: Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity.
abstract: Two pyrazine derivatives [fructosazine (3) and deoxyfructosazine (6)] were simultaneously formed in a solution of D-glucosamine hydrochloride under various conditions. They showed deoxyribonucleic acid (DNA) strand breakage activity in plasmid pBR322 comparable to that of D-glucosamine. The DNA strand breakage by fructosazine (3) was stimulated by Cu2+.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sumoto
authors.forename: M
authors.initials: M
authors.lastname: Irie
authors.forename: N
authors.initials: N
authors.lastname: Mibu
authors.forename: S
authors.initials: S
authors.lastname: Miyano
authors.forename: Y
authors.initials: Y
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D004249:DNA Damage; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011719:Pyrazines; C017737:tagatosazine; C069873:deoxyfructosazine