Effect of verapamil on intestinal absorption of calcium in the rat.
The effect of verapamil in vitro, and the in vivo effect of both oral and parenteral verapamil administration on intestinal absorption was tested using everted gut sacs of duodenum, jejunum, distal ileum and proximal colon in rats. In the in vivo study, the effect of verapamil on blood levels of calcium, phosphorus and 1.25(OH)2D3, was investigated and a complete calcium balance was performed. In vitro, verapamil (1.5 mM) inhibited calcium absorption by the duodenum and colon only. Oral verapamil led to a reduction in the blood level of 1.25(OH)2D3. However, both oral and parenteral verapamil had no effect on the intestinal absorption, urinary secretion and consequently on the calcium balance.
Gafter
U
U
Department of Nephrology, Hasharon Hospital, Petah-Tiqva, Israel.
Barak
H
H
Hirsh
J
J
Edelstein
S
S
Levi
J
J
D000818:Animals; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002132:Calcium Radioisotopes; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D008297:Male; D010758:Phosphorus / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D010758:Phosphorus; D014700:Verapamil; D002117:Calcitriol; D002118:Calcium