[The effect of amino acids in the asparagine family on the aspartate kinase and homoserine dehydrogenase of ethionine-resistant mutants of Pseudomonas putida].
The activity of aspartate kinase and homoserin dehydrogenase from ethionine resistant mutants Pseudomonas putida 25 and 6 have been studied as affected by amino acids from the family of asparagine. They are characterized by a capacity to the surplus synthesis of methionine. It is shown that mutants have negative regulation of the level of activity of the studied enzymes. It is supposed that the mutations (or mutation) could take place which affected properties of enzymes, which participated directly in the biosynthesis of methionine, in the analogue resistant clones 25 and 6.
Polodienko
O B
OB
Chistoserdov
A Iu
AIu
Totskiĭ
V N
VN
Tsygankov
Iu D
IuD
D001216:Asparagine / Q000096:biosynthesis / Q000494:pharmacology*; D001222:Aspartate Kinase / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005001:Ethionine / Q000037:antagonists & inhibitors*; D006715:Homoserine Dehydrogenase / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D009154:Mutation / Q000187:drug effects*; D011549:Pseudomonas / Q000187:drug effects* / Q000201:enzymology
D001216:Asparagine; D006715:Homoserine Dehydrogenase; D001222:Aspartate Kinase; D005001:Ethionine
Vliianie aminokislot asparaginovogo semeĭstva na aktivnost' aspartatkinazy i gomoserindegidrogenazy étioninrezistentnykh mutantov Pseudomonas putida.