title: [The semisynthetic production of pharmacologically active flavone derivatives. I. The pharmaco-toxicological properties of theophylline-rutozide (TR 1722)].
abstract: The pharmaco-toxicological properties of the compound theophylline-rutozide, termed conventionally TR-1722, are presented. Studied comparatively with aminophylline, it presents important advantages: soluble in water, the aqueous solutions have a pH close to the physiological one and are stable. It induces a weaker excitation on the central nervous system as compared to aminophylline, but its antihistaminic and anti-inflammatory properties are slightly increased. The physicochemical and pharmacological properties of TR 1722 recommend it for the patients with asthma and associated arterial hypertension or obstructive bronchopneumopathy associated with pulmonary hypertension.
authors.affiliation: Disciplina de chimie farmaceutică, Institutul de Medicină şi Farmacie Iaşi.
authors.forename: G
authors.initials: G
authors.lastname: Dănilă
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
mesh_terms: D000628:Aminophylline / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001986:Bronchial Spasm / Q000188:drug therapy; D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D005419:Flavonoids / Q000138:chemical synthesis*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D051381:Rats; D012431:Rutin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D013806:Theophylline / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005419:Flavonoids; C068270:theophylline-rutozide; D000628:Aminophylline; D012431:Rutin; D013806:Theophylline
vernacular_title: Cercetări privind obţinerea prin semisinteză a unor derivaţi flavonici farmacologic activi. I. Unele însuşiri farmaco-toxicologice ale teofilin-rutozidului (TR 1722).