Absorption of paracetamol from suppositories in geriatric patients with fecal accumulation in the rectum.
The bioavailability of paracetamol from suppositories was studied in 16 geriatric in-patients in stable clinical condition; 9 had significant amounts of feces in the rectum. Rectal accumulation of feces reduced the peak plasma paracetamol concentration by 32% (p = 0.05) and the AUC0-8h by 27% (p = 0.04). The peak concentration, however, appeared earlier among patients with rectal accumulation of feces. Compared to findings in 6 healthy young controls, geriatric patients had higher plasma concentrations of the main paracetamol metabolites.
Hagen
I J
IJ
University Department of Geriatric Medicine, Ullevaal Hospital, Oslo, Norway.
Haram
E M
EM
Laake
K
K
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D005244:Fecal Impaction / Q000378:metabolism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D012007:Rectum / Q000378:metabolism*; D013488:Suppositories / Q000493:pharmacokinetics*
D013488:Suppositories; D000082:Acetaminophen