[Pharmacological interactions between diltiazem and thiopental. A study on an electrophysiological model of guinea pig isolated papillary muscle. Value of positive inotropic agent].
This study was designed to assess in vitro the effects of Thiopental alone and Thiopental--Dobutamine association on control and on Diltiazem pretreated papillary muscle. The Diltiazem treatment do not increase the negative inotropic effect of Thiopental but the effect of Dobutamine is less important in pretreated group. The Diltiazem treatment protect to arrhythmogenic action of Thiopental and Thiopental-Dobutamine association.
Stimmesse
B
B
Département d'Anesthésie Réanimation, Centre Hospitalier et Universitaire Jean Minjoz, Besançon.
Kantelip
J P
JP
Coste
Y
Y
Capellier
G
G
Barale
F
F
Magnin
P
P
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004110:Diltiazem / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology; D004347:Drug Interactions; D006168:Guinea Pigs; D008954:Models, Biological; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects*; D013874:Thiopental / Q000009:adverse effects / Q000494:pharmacology*
D004280:Dobutamine; D004110:Diltiazem; D013874:Thiopental
Interactions pharmacologiques entre diltiazem et thiopental. Etude sur un modèle électrophysiologique de muscle papillaire isolé de cobaye. Intérêt d'un inotrope positif.