Autoimmune neutropenia and Hodgkin's disease: successful treatment with intravenous gammaglobulin.
We describe a child with Hodgkin's disease (HD) who presented with profound neutropenia, secondary to an antineutrophil antibody. The patient responded to intravenous immunoglobulin (IVIG), with prompt and sustained improvement in total white blood cell count (WBC) and absolute neutrophil count (ANC). The literature pertaining to autoimmune cytopenias complicating HD is reviewed, as well as the role of IVIG in management of these disorders.
Gordon
B G
BG
Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198-2185.
Kiwanuka
J
J
Kadushin
J
J
D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy*; D002648:Child; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007116:Immunization, Passive; D007262:Infusions, Intravenous; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000276:immunology / Q000628:therapy*