Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite.
1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine. 2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer.
Voncken
P
P
INBIFO Institut für biologische Forschung, Köln, FRG.
Rustemeier
K
K
Schepers
G
G
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003367:Cotinine / Q000031:analogs & derivatives* / Q000652:urine; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007275:Injections, Intravenous; D008297:Male; D008647:Mesocricetus; D009538:Nicotine / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012015:Reference Standards; D012907:Smoking / Q000652:urine; D013237:Stereoisomerism
C001381:hydroxycotinine; D009538:Nicotine; D003367:Cotinine