[Physico-chemical studies of aluminum hydroxide in biological preparations preserved in different conditions].
An observation of physico-chemical properties of 0.5% Al(OH)3 and vaccines adsorbed to it (Di, Te, Di-Te, Di-Te-Per) stored for 3-24 months in various pH (5, 7, 8) and temperatures -18 degrees, +37 degrees, +45 degrees and +65 degrees was carried out. For this purpose an analysis of sedimentation rate, microscopic observation and ++roentgenographic analysis were performed. It was found that a decrease of storage temperature of Al(OH)3 gel and vaccines down to -18 degrees C resulted in some changes in structure and morphology of this absorbent (big precipitates) and it led to a significant increase of sedimentation rate.
Aleksandrowicz
J
J
Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Drozdz
M
M
Fiejka
M
M
Kurzatkowski
W
W
D000276:Adjuvants, Immunologic / Q000032:analysis; D000536:Aluminum Hydroxide / Q000032:analysis*; D011232:Chemical Precipitation; D004168:Diphtheria Toxoid / Q000032:analysis*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D011309:Preservation, Biological / Q000379:methods*; D013696:Temperature; D013745:Tetanus Toxoid / Q000032:analysis*
D000276:Adjuvants, Immunologic; D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid; D000536:Aluminum Hydroxide
Ocena fizyko-chemicznego stanu wodorotlenku glinu w biopreparatach przechowywanych w róznych warunkach.