title: The relationship of documented destruction of specific cell types to complications and effectiveness in thalamotomy for tremor in Parkinson's disease.
abstract: Microstimulation and single unit recording techniques were used to explore the thalamus prior to performance of 18 thalamotomies in 13 patients. Identified tactile, kinesthetic and tremor-synchronous cells were mapped to scale. Lesion sizes were determined experimentally from lesions made in rat thalami and superimposed on the human maps. Effectiveness and complications were evaluated vis-à-vis documented destruction of tactile kinesthetic and tremor-synchronous cells.
authors.affiliation: Department of Neurosurgery, SUNY Health Science Center, Syracuse.
authors.forename: M W
authors.initials: MW
authors.lastname: Jones
authors.forename: R R
authors.initials: RR
authors.lastname: Tasker
mesh_terms: D001931:Brain Mapping / Q000295:instrumentation; D004558:Electric Stimulation / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery; D011183:Postoperative Complications / Q000503:physiopathology*; D013238:Stereotaxic Techniques / Q000295:instrumentation; D013787:Thalamic Nuclei / Q000503:physiopathology* / Q000601:surgery; D014202:Tremor / Q000503:physiopathology* / Q000601:surgery