Comparison of cell growth in different parts of breast cancers.
This study was performed to answer the question: which parts of breast cancers are active in terms of proliferation as measured by the Ki-67 antibody and in terms of cell division as measured by the mitotic index. Forty-six breast samples were studied, including 34 breast cancers and 12 benign conditions. The intraductal component of infiltrating breast cancers showed a significantly lower proliferation index than the infiltrating component. The cells at the periphery of infiltrating tumour strands showed a higher proliferation activity than the cells in the core. These findings suggest that infiltration advances through preferential active growth of the cells at the invasion front.
Verhoeven
D
D
Department of Pathology, University Hospital, Antwerp, Belgium.
Bourgeois
N
N
Derde
M P
MP
Kaufman
L
L
Buyssens
N
N
D000954:Antigens, Surface; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division; D006801:Humans; D019394:Ki-67 Antigen; D008940:Mitotic Index
D000954:Antigens, Surface; D019394:Ki-67 Antigen