title: Mechanisms in microbial evolution.
abstract: Molecular genetic studies with prokaryotic microorganisms reveal that many different molecular processes contribute to the formation of spontaneous mutations. Besides infidelities in DNA replication and the consequences of environmental mutagens, enzyme-mediated DNA rearrangements bring about important, evolutionarily relevant alterations in the genetic information. Particular attention is given in this article to site-specific recombination at secondary crossover sites and to the transposition of mobile genetic elements with relaxed target specificity. Besides these diverse processes of genomic mutation the acquisition of genetic information from other organisms plays an uncontested role in microbial evolution. Enzymes and organelles mediating any of these mutational processes can be looked at as biological functions acting at the level of populations for the needs of biological evolution, rather than to fulfill the needs of individual living organisms.
authors.affiliation: Department of Microbiology, University of Basel, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Arber
mesh_terms: D001419:Bacteria / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D003434:Crossing Over, Genetic; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D011995:Recombination, Genetic
chemical_list: D004269:DNA, Bacterial