title: Erythroleukemia in a child associated with monosomy 7.
abstract: A case of erythroleukemia (EL) associated with monosomy 7 is reported. The EL was diagnosed 20 months after the initial diagnosis of monosomy 7 was made. An immunologic study of the blast cells using a monoclonal antibody was positive for glycophorin A, which suggested that they were of erythroid origin; this was confirmed by electron microscopy. Chemotherapy was started with low dose cytarabine. However, the patient had severe bone marrow suppression and died of pneumonia. Our case shows that monosomy 7 is an abnormality of the pluripotential stem cells, including erythroid cells, that resulted in a true erythroid neoplasm.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shitara
authors.forename: S
authors.initials: S
authors.lastname: Yugami
authors.forename: M
authors.initials: M
authors.lastname: Sotomatu
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Ijima
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
mesh_terms: D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7; D004912:Erythrocytes / Q000737:chemistry / Q000648:ultrastructure; D004920:Erythropoiesis; D006021:Glycophorins / Q000032:analysis; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D008297:Male; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000150:complications
chemical_list: D006021:Glycophorins