Plasticisers, another burden for asthmatics?
The widely used plasticiser di(2-ethylhexyl)phthalate (DEHP) has been reported to have some toxicological effects on pulmonary tissue. Inhalation of DEHP may cause pulmonary edema and bronchial asthma. Moreover intravenous injection of DEHP induces pulmonary inflammation and hemorrhage of the lungs. We now report that DEHP might cause bronchial hyperresponsiveness. The metabolite of DEHP mono(2-ethylhexyl)phthalate (MEHP) induces in vitro a dose-dependent increase in -log EC50 for methacholine dose response curves in rat tracheal tissue. Moreover MEHP induces a decrease in maximal effect of the methacholine dose response curve. We concluded that DEHP due to the formation of MEHP in vivo, may cause bronchial hyperresponsiveness.
Doelman
C J
CJ
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
Borm
P J
PJ
Bast
A
A
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D004051:Diethylhexyl Phthalate / Q000494:pharmacology / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D010968:Plasticizers / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea / Q000187:drug effects
D007546:Isoquinolines; D010879:Piperazines; D010968:Plasticizers; D016210:Methacholine Chloride; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate