Vasopressin and oxytocin modulation of melatonin secretion from rat pineal glands.
The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. Since vasopressin (VP)- and oxytocin (OT)-containing fibers innervate the pineal gland, the effects of VP and OT on melatonin release from perifused rat pineal glands were investigated. VP (10(-7) M) and OT (10(-6) M) decreased the basal melatonin secretion. No dose-dependent effect was observed. At high concentrations (10(-5)) these peptides potentiated the isoproterenol-induced increase of melatonin secretion. Below 10(-5) M no potentiation was observed. Fragments of VP ([pGlu4,Cys6]VP(4-9] and OT (pGlu4,Cys6]OT(4-9] did not display any effect on the isoproterenol-induced melatonin secretion.
Simonneaux
V
V
CNRS-URA 1332 Neurobiologie des fonctions rythmiques et saisonnières, Université Louis Pasteur, Strasbourg, France.
Ouichou
A
A
Burbach
J P
JP
Pévet
P
P
D000818:Animals; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D010121:Oxytocin / Q000502:physiology*; D010477:Perfusion; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000502:physiology*
D014667:Vasopressins; D010121:Oxytocin; D008550:Melatonin; D007545:Isoproterenol