title: Acute tumor lysis syndrome in a patient with chronic myelogenous leukemia in blast crisis: role of high-dose Ara-C.
abstract: A patient with chronic myelogenous leukemia (CML) in lymphoid blast crisis developed acute tumor lysis syndrome following administration of high-dose busulfan, cyclophosphamide and cytarabine (Ara-C) in preparation for allogeneic bone marrow transplantation. Preconditioning cytoreduction, close monitoring and rapid institution of therapeutic measures were required to avoid renal failure and a fatal outcome. Acute tumor lysis syndrome has not been reported in marrow transplant patients receiving conventional preparative regimens as treatment for CML in blast crisis, and it is likely that its occurrence in this patient was precipitated by high-dose Ara-C.
authors.affiliation: Pittsburgh Cancer Institute Adult Bone Marrow Transplant Unit, University of Pittsburgh, PA.
authors.forename: D
authors.initials: D
authors.lastname: Przepiorka
authors.forename: R
authors.initials: R
authors.lastname: Gonzales-Chambers
mesh_terms: D000208:Acute Disease; D000328:Adult; D001752:Blast Crisis / Q000150:complications* / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000379:methods; D003561:Cytarabine / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007674:Kidney Diseases / Q000517:prevention & control; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D015275:Tumor Lysis Syndrome / Q000209:etiology* / Q000473:pathology
chemical_list: D003561:Cytarabine