[Variations of vasoactive intestinal peptide (VIP) concentration in the lung of asthmatic patients].
The vasoactive intestinal peptide (VIP) concentrations in the pulmonary and systemic arterial blood were evaluated in 11 asthmatic patients in symptom-free period and during methacholin induced broncospasm. The basal venous and arterial mean values do not significantly differ. A significant difference was observed after bronchial challenge. This could be caused by an increased VIP pulmonary production as a defensive mechanism. No correlation was found between bronchial reactivity (as PD20-FEV1 Methacholin) and VIP concentrations.
Bottino
G
G
ISMI - Instituto Scientifico di Medicina Interna, Genova.
Moscatelli
P
P
Antgognozzi
G
G
De Grandi
R
R
Augeri
C
C
Garfagnini
A
A
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide
Variazioni del peptide intestinale vasoattivo (VIP) nel passaggio attraverso il polmone nella malattia asmatica.