title: The impact of treatment on the natural history of endometriosis.
abstract: A group of 50 infertile female patients was assessed laparoscopically to study the natural history of endometriosis. They were treated either with danazol (n = 21), or diathermy ablation (n = 13) or had conservative surgery with postoperative danazol (n = 5) or were left untreated (n = 11). All these patients had second look laparoscopy performed after a mean interval of 12 months (range 9-18 months). Improvement was noted among 53% of those treated with danazol, 70% treated with diathermy, 80% treated with surgery and danazol and 27% of those left untreated. The status of endometriosis remained unchanged among 14% of those treated with danazol, 8% treated by diathermy and 9% of those left untreated. However, the disease became worse in the remaining women, 33% in the danazol treated group, 22% treated by diathermy, 20% treated with surgery and danazol and 64% of those left untreated. Thus treatment hinders progression in a majority of patients, and conversely, there is a small but definite spontaneous regression rate.
authors.affiliation: Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Mahmood
authors.forename: A
authors.initials: A
authors.lastname: Templeton
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003613:Danazol / Q000009:adverse effects / Q000627:therapeutic use; D003972:Diathermy / Q000009:adverse effects; D004715:Endometriosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005184:Fallopian Tube Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D010049:Ovarian Diseases / Q000209:etiology; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D003613:Danazol