title: [Accelerated desensitization to Dermatophagoides pteronyssinus mites in children with asthma. Results of two years of immunotherapy].
abstract: 16 children with chronic asthma were given a rush immunotherapy with standardized Dermatophagoides Pteronyssinus extracts. For two years, the dose of 10 IR was injected monthly. Before this rush, six children have received a typical immunotherapy ineffective on asthma. Examination of clinical, medication, immuno-allergologic and functional parameters were recorded before and at 6, 12 and 24 months of the follow-up. Rush immunotherapy was well tolerated. Substantial improvement of asthmatic syndrome was seen in 12 children. Skin sensitivity decreased significantly since 6 months (p less than 0.001). Laboratory results were not changed. At 24 months, improvement of CRF Helium was showed (p less than 0.01). This study with two years follow-up shows that specific immunotherapy is efficacy and possible in children with severe asthma. Symptom, medication, functional scores were substantial improvement.
authors.forename: P
authors.initials: P
authors.lastname: Le Roux
authors.forename: B
authors.initials: B
authors.lastname: Le Luyer
mesh_terms: D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000379:methods*; D004391:Dust / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D008297:Male; D008925:Mites / Q000276:immunology*; D012129:Respiratory Function Tests; D012882:Skin Tests
chemical_list: D004391:Dust; D007073:Immunoglobulin E
vernacular_title: Désensibilisation accélérée aux acariens dermatophagoïdes pteronyssinus dans l'asthme de l'enfant. Bilan de deux années d'immunothérapie.