[Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].
The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.
Lu
X D
XD
Department of Pharmacology, Xi-an Medical University, China.
Zhao
G S
GS
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010210:Papillary Muscles / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D008787:Metoclopramide