title: [The pathogenesis of congenital thymus hyperplasia in children with immune defects].
abstract: Complex clinical and morphological studies were conducted into conditions of the thymus as well as of the lymphatic and neuro-endocrine systems in stillbirths and children up to five years of age. Thymic hormones in blood and thymic tissue were determined, as well. CTH, in most of these cases, was found to reflect dysfunction of the hypothalamic-hypophyseal system which eventually resulted in development of polyglandular endocrinopathy and congenital immune deficiency, primarily in the T-system. CTH has proved quite often to be associated with congenital malformations.
authors.affiliation: Lehrstuhl für Pathologische Anatomie des 1. Moskauer Medizinischen I.-M.-Setschenov-Instituts, Moskau, UdSSR.
authors.forename: O V
authors.initials: OV
authors.lastname: Zajratjanc
authors.forename: V V
authors.initials: VV
authors.lastname: Serov
authors.forename: L G
authors.initials: LG
authors.lastname: Kuzmenko
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000151:congenital*; D007223:Infant; D007231:Infant, Newborn; D008208:Lymphatic System / Q000473:pathology*; D008297:Male; D009490:Neurosecretory Systems / Q000473:pathology*; D013601:T-Lymphocytes; D013950:Thymus Gland / Q000737:chemistry / Q000473:pathology*; D013951:Thymus Hormones / Q000032:analysis / Q000097:blood; D013952:Thymus Hyperplasia / Q000151:congenital* / Q000209:etiology
chemical_list: D013951:Thymus Hormones
vernacular_title: Zur Pathogenese der angeborenen Thymushyperplasie (ATH) bei Kindern mit Immundefekten.