Myocardial calcifications in neonates and infants: a unique tissue reaction.
The deposit of calcium salts into myocardial cells represents the process of dystrophic calcification. Once it causes alterations in cellular calcium hemostasis, it can initiate deleterious events leading to ischemic myocardial injury and cell death. Myocardial calcifications in infants are markedly different from those in adults; calcifications are significantly more frequent in cases of myocardial necrosis in the young, and can be demonstrated microscopically without removal of necrotic fibers and scar formation, which are the adult's usual stages of response to myocardial necrosis. Important functional and clinical implications in myocardial calcification, other than serving as a marker for necrosis, relate to accelerated myocardial calcification after cardiac surgery in infants.
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Division of Cardiology, University Hospitals of Cleveland, Case Western Reserve University, OH 44106.
D002114:Calcinosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D009202:Cardiomyopathies / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008929:Mitochondria, Heart / Q000378:metabolism / Q000473:pathology; D009336:Necrosis
D002118:Calcium