Failure of cholecystokinin to precipitate withdrawal in morphine-treated rats.
In a test of the possible antagonistic interaction between cholecystokinin (CCK) and morphine, morphine-dependent rats were injected with one of three doses of CCK or with naloxone immediately following the consumption of a novel saccharin solution. Whereas opiate-dependent rats injected with the opiate antagonist naloxone acquired an aversion to the saccharin solution (and displayed a dramatic weight loss), CCK was without effect. These data were discussed in relation to the possible pharmacological antagonism between CCK and the opiates.
Pournaghash
S
S
Department of Psychology, American University, Washington, DC 20016.
Riley
A L
AL
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002766:Cholecystokinin / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D009021:Morphine Dependence / Q000503:physiopathology* / Q000523:psychology; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D002766:Cholecystokinin