title: Anticoagulant properties of placenta protein 4 (annexin V).
abstract: A placenta protein, originally termed PP4, was found to inhibit the aPTT in a concentration-dependent manner. PP4 which turned out to be identical with a vascular anticoagulant of the annexin type, inhibits the blood clotting process by binding of the essential lipids in a reaction which is dependent on calcium ions. Also in the presence of calcium PP4 combines with platelet membranes neutralizing their procoagulant effect. By fluorescence-microscopy binding of PP4 to stimulated macrophages is shown. The antithrombotic effect of PP4 is demonstrated by means of thrombelastography of human blood. Coagulation triggered by the addition of thromboplastin/lipid-mixtures is extinguished by PP4.
authors.affiliation: Research Laboratories of Behringwerke AG, Marburg, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Römisch
authors.forename: U
authors.initials: U
authors.lastname: Schorlemmer
authors.forename: K
authors.initials: K
authors.lastname: Fickenscher
authors.forename: E P
authors.initials: EP
authors.lastname: Pâques
authors.forename: N
authors.initials: N
authors.lastname: Heimburger
mesh_terms: D000925:Anticoagulants; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000502:physiology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D010314:Partial Thromboplastin Time; D011257:Pregnancy Proteins / Q000502:physiology*; D011485:Protein Binding; D013916:Thrombelastography; D015054:Zymosan / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D008055:Lipids; D011257:Pregnancy Proteins; D015054:Zymosan