[The bioequivalence of intramuscular and subcutaneous administration of a formulation of oxytetracycline in the young bull].
A bioequivalence study was performed in 6 bullocks to compare intramuscular (im) and subcutaneous (sc) routes for repeated treatments with an oxytetracycline formulation. Basic pharmacokinetic parameters were determined after a 10 mg/kg intravenous administration. Bioavailabilities for both im et sc routes were close to 85%. The pharmacokinetic parameters were used to perform an analysis of variance, and to determine the 95% confidence intervals and Westlake symmetrical confidence intervals. The two routes were significantly different regarding maximum concentration. The following symmetrical confidence intervals were calculated: area under the curve (+/- 20%), minimum concentration (+/- 51.5%), period during which plasma concentration was above 1 microgram/ml (+/- 25%). The two routes were bioequivalent for the area under curve.
Sanders
P
P
Centre National d'Etudes Vétérinaires et Alimentaires, Laboratorire des Médicaments Vétérinaires, Fougères, France.
Guillot
P
P
D000704:Analysis of Variance; D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D010118:Oxytetracycline
Etude de la bioéquivalence des voies d'administration intramusculaire et sous-cutanée pour une formulation d'oxytétracycline chez le taurillon.