Changes in serum enzyme activities in splanchnic ischemia shock.
Wistar male rats underwent a midline ventral abdominal incision under pentobarbital anaesthesia and were divided into two groups: the experimental rats were injected with 0.04 ml.kg-1 bodyweight Ethibloc (Ethicon-FRG) into a tributary of the superior mesenteric vein, close to the hepatic portal vein and the control, saline. The animals were sacrificed by decapitation on the 1st and on the 30th day after the treatment. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities are significantly increased at the 24 hr following the i.v. injection in the experimental rats. The 30th LDH5 level is decreased 19% in the experimental group from the ones in the control group. The serum activities of lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), gamma-glutamyl transpeptidase (GGTP) and serum cholinesterase do not differ substantially in the experimental group from these in the control group in the different periods of assessment.
Voinikova
I
I
Départment of Pathophysiology, Medical Academy, Sofia.
Dochev
D
D
Petkova
M
M
Suzuki
A
A
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000201:enzymology* / Q000503:physiopathology; D013152:Splanchnic Circulation
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase