title: Fibrin tissue adhesive sealant for the prevention of CSF leakage following transsphenoidal microsurgery.
abstract: Fibrin glue (Beriplast, Behring or Tissucol, Immuno) was used for 126 sublabial transseptal transsphenoidal operations in 119 patients from April 1981 to March 1987 in a variety of sellar pathologies together with septal bone and spongycel to seal the sellar floor and the anterior wall of the sphenoid sinus. The incidence of postoperative rhinorrhea was 1.6%. A review of the literature revealed an incidence of 1.5%-9.6% with the use of autologous tissue for sellar packing such as fat or muscle; fibrin glue combined with autologous grafts led to postoperative rhinorrhea in 1%-4.4%. The present results support the view that sellar and sphenoidal sealing with fibrin glue instead of muscle or fat tissue does not raise the incidence of postoperative rhinorrhea.
authors.affiliation: Department of Neurosurgery, University of Gent, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Van Velthoven
authors.forename: G
authors.initials: G
authors.lastname: Clarici
authors.forename: L M
authors.initials: LM
authors.lastname: Auer
mesh_terms: D000236:Adenoma / Q000601:surgery*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000517:prevention & control*; D003397:Craniopharyngioma / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008866:Microsurgery / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010911:Pituitary Neoplasms / Q000556:secondary / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D012086:Reoperation; D013101:Sphenoid Sinus / Q000601:surgery*
chemical_list: D015718:Fibrin Tissue Adhesive