Changes in the levels of catecholamines, hexokinase and glucose 6-phosphate dehydrogenase in red cell aging.
The activity of the enzymes hexokinase and glucose 6-phosphate dehydrogenase and the level of catecholamines were measured in isolated rat Red Blood Cells (RBC) during cellular aging. The results clearly showed a linear decline in the two enzyme profiles with corresponding increase in age of RBC. A decrease of 75-85% in the activities were found in the oldest cell fractions as compared to the youngest. The levels of glycosylated haemoglobin and catecholamines were found to increase with aging. A correlation can probably be established between the enzyme activities, the levels of glycosylated haemoglobulin and catecholamines during aging.
Nehal
M
M
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Azam
M
M
Baquer
N Z
NZ
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004837:Epinephrine / Q000097:blood*; D004905:Erythrocyte Aging / Q000502:physiology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006593:Hexokinase / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D015415:Biomarkers; D004837:Epinephrine; D005954:Glucosephosphate Dehydrogenase; D006442:Glycated Hemoglobin; D006593:Hexokinase; D009638:Norepinephrine