[Macroprolactinemia in a child].
An hyperprolactinemia, with basal serum prolactin levels ranging from 41 to 135 ng/ml was found to be coincidentally associated with psychosocial dwarfism in a 11 year-old boy. Sephadex G 100 exclusion chromatography showed that the predominating form of immunoreactive prolactin levels ranging from 41 to 135 ng/ml was found to be weight, differing from the regular occurrence of a 22 kilodalton major variant. Prolactin levels increased under TRH (increments between 29 and 76%) but were not blunted by bromocriptine at a dose of 2.5 mg/day. This so-called macroprolactinemia syndrome should be searched for whenever a discrepancy is noted between clinical symptoms and blood prolactin levels.
Weill
J
J
l'Unité d'Endocrinologie Pédiatrique, Hôpital A. Calmette, Lille.
Petit
S
S
Stuckens
C
C
Descamps
Y
Y
Racadot
A
A
Boersma
A
A
Ponte
C
C
D000293:Adolescent; D001971:Bromocriptine / Q000627:therapeutic use; D002850:Chromatography, Gel; D004392:Dwarfism / Q000150:complications*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D011388:Prolactin / Q000097:blood
D001971:Bromocriptine; D011388:Prolactin
Macroprolactinémie chez un enfant.