Human Caki-1 cells are the first model for extraneuronal transport of noradrenaline (uptake2) which is based on a clonal cell line.
The neurotransmitter noradrenaline is inactivated by active transport out of the synaptic cleft--either back into the adrenergic neuron or into extraneuronal cells. Transport studies on isolated cells provide many advantages. However, an experimental model for the extraneuronal uptake of noradrenaline which is based on a clonal cell line was not known until now. The human renal carcinoma cell line Caki-1 is the first clonal cell line known to express the extraneuronal transport system for noradrenaline.
Schömig
E
E
Department of Pharmacology, University of Würzburg, Federal Republic of Germany.
Babin-Ebell
J
J
Schönfeld
C L
CL
Russ
H
H
Trendelenburg
U
U
D000818:Animals; D002460:Cell Line; D002927:Cimetidine / Q000494:pharmacology; D002999:Clone Cells / Q000378:metabolism; D003345:Corticosterone; D006801:Humans; D007545:Isoproterenol / Q000031:analogs & derivatives; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009132:Muscles / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D009893:Opossums; D011342:Procainamide / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
C008401:metiprenaline; D002927:Cimetidine; D011802:Quinidine; D011342:Procainamide; D007545:Isoproterenol; D003345:Corticosterone; D009638:Norepinephrine