[A comparative study of the antiheparin activity and acute toxicity of stellins].
The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin.
Grigorova
L V
LV
Rozkin
M Ia
MIa
Rybin
V K
VK
Efimov
V S
VS
Makarov
N V
NV
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D029941:Fish Proteins; D006494:Heparin Antagonists / Q000494:pharmacology* / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D011479:Protamines / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
D029941:Fish Proteins; D006494:Heparin Antagonists; D011479:Protamines; C029829:protamine B, Acipenser gueldenstaedtii; C025098:Stellin; C029828:protamine A, Acipenser stellatus
Sravnitel'noe issledovanie antigeparinovoĭ aktivnosti i ostroĭ toksichnosti stellinov.