[Does pulmonary air embolism affect the pulsatility of pulmonary capillary blood flow in dogs?].
The difference in the uptake rate through the lungs between nitrous oxide and oxygen has been shown to represent the pulmonary capillary blood flow (Qc). The pulsatility of Qc, defined as the ratio of maximum Qc and mean Qc (Qc max/Qc), the ratio of Qc max and stroke volume (Qc max/SV), and the ratio of systolic Qc and SV (Vsyst/SV), has been also shown to indicate the pulmonary vasodilation as well as vasoconstriction. We measured Qc by means of body plethysmography in dogs with pulmonary air embolism, in order to evaluate its effect on the pulmonary vasculature. Ten adult dogs were anesthetized with pentobarbital and pancuronium, and were mechanically ventilated. A volume of air (0.5 ml/kg) was injected into the central vein. Although there was no significant change in systemic blood pressure, cardiac output, heart rate, and airway pressure after the injection of air, pulmonary arterial pressure and pulmonary vascular resistance increased significantly. Qc, Qc max, Qc max/Qc, and Qc max/SV decreased significantly after the air injection. Since these findings suggest that the pulmonary air embolism provoked pulmonary vasoconstriction, and attenuated the pulsatility of Qc, optimal pulmonary vasodilation therapy would be recommended to improve the pulmonary hypertension secondary to pulmonary air embolism.
Iwao
Y
Y
Department of Anesthesiology, Kyorin University School of Medicine, Tokyo.
Masuda
J
J
Ochiai
R
R
Higa
S
S
Takeda
J
J
Sekiguchi
H
H
Nagano
M
M
D000818:Animals; D002196:Capillaries / Q000503:physiopathology; D004285:Dogs; D004618:Embolism, Air / Q000503:physiopathology*; D008168:Lung / Q000098:blood supply*; D011655:Pulmonary Embolism / Q000503:physiopathology*; D011673:Pulsatile Flow / Q000502:physiology