[Selective inhibitory effects of experimental potassium depletion on urinary excretion of prostanoids and their possible functional significance].
The urinary concentrations of prostaglandins(PG) E2, 6-keto-PGF1 alpha (6KPGF) and thromboxane (Tx) B2 were measured by RIA method during both hypotonic polyuria (oral water load) and subsequent antidiuresis (low-dose infusion of lysine-8-vasopressin). The study was performed on healthy women either in normal potassium balance (N, n = 14) or sustained potassium depletion (D3, n = 6). Potassium depletion (KD) was induced by low potassium dietary intake (less than or equal to 10 mmol/d) and natriuretic treatment over a period of 8 days; the net losses of NaCl and H2O were replaced; the cumulative potassium deficit was 198 +/- 22 mmol. Further studies were performed after indomethacin treatment in both experimental conditions. 1) As compared to normal potassium balance in KD group the urinary prostanoid excretions were reduced even in absence of significant differences in urinary flow rate. The urinary excretion of 6KPGF was more impaired than that of TxB2 in both polyuria and antidiuresis. 2) Indomethacin inhibited the urinary prostanoid excretions in normal potassium balance and KD groups. The urinary excretion of PGE2 was more impaired than that of both 6KPGF and TxB2.
Agnoli
G C
GC
Cattedra di Semeiotica Medica dell'Università di Bologna.
Borgatti
R
R
Cacciari
M
M
Garutti
C
C
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
D000328:Adult; D004231:Diuresis; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D009318:Natriuresis; D011188:Potassium / Q000008:administration & dosage; D011191:Potassium Deficiency / Q000652:urine*; D011453:Prostaglandins / Q000652:urine*
D011453:Prostaglandins; D011188:Potassium; D007213:Indomethacin
Effetti inibitori selettivi della deplezione potassica sperimentale sulla escrezione urinaria dei prostanoidi e loro possibile significato funzionale.