The effect of nimodipine on outcome after head injury: a prospective randomised control trial. The British/Finnish Co-operative Head Injury Trial Group.
To study the effect of nimodipine on the outcome of head injury, three hundred and fifty-two patients who were not obeying commands were randomised to placebo or nimodipine (2 mg per hour intravenously for 7 days). The 2 groups were well matched for important prognostic features. Six months after injury, more of the patients who were given nimodipine had a favourable outcome (moderate/good recovery) than in the control group, but the increase in favourable outcome (8%) was not significant statistically.
Teasdale
G
G
Department of Neurosurgery, Southern General Hospital, Belfast.
Bailey
I
I
Bell
A
A
Gray
J
J
Gullan
R
R
Heiskanan
U
U
Marks
P V
PV
Marsh
H
H
Mendelow
A D
AD
Murray
G
G
D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use*; D011379:Prognosis; D011446:Prospective Studies
D009553:Nimodipine