Mucorales and deferoxamine: from saprophytic to pathogenic state.
Rhinocerebral mucormycosis can be a rapidly fatal course disease if the institution of treatment is delayed. We describe a case of a long-term dialysis patient in which the role of a siderophore such as Deferoxamine in promoting mucormycosis is discussed. The frequent lack of early diagnosis, itself subsequent to a break away from the standard diagnostic tools (apart from biopsy and culture) makes the survival prognosis particularly critical.
Vandevelde
L
L
ENT Dept., Brugmann University Hospital.
Bondewel
C
C
Dubois
M
M
De Vuyst
M
M
D003676:Deferoxamine / Q000009:adverse effects*; D015521:Ethmoid Sinusitis / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000601:surgery; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects; D012851:Sinus Thrombosis, Intracranial / Q000209:etiology*; D014057:Tomography, X-Ray Computed
D003676:Deferoxamine