Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia.
From May 1980 to December 1989, 107 consecutive patients with non-constitutional severe aplastic anemia underwent bone marrow transplantation at our institution using cyclophosphamide and thoraco-abdominal irradiation as conditioning regimen. During the same period, 40 patients with Fanconi anemia were also grafted after a similar conditioning, giving a total series of 147 patients. With a mean follow-up of 64 months, four male patients developed a solid malignant tumor, a number that leads to an 8-year cumulative incidence rate of 22% (eg, relative risk to general population = 41, P less than .001). These results should be considered as a warning to clinicians who follow these successfully grafted long-term patients.
Socié
G
G
Bone Marrow Transplant Unit, Hôpital Saint-Louis, Paris, France.
Henry-Amar
M
M
Cosset
J M
JM
Devergie
A
A
Girinsky
T
T
Gluckman
E
E
D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005199:Fanconi Anemia / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies