Male mediated teratogenic potential evaluation of new antifertility compound SMA in rabbit (Oryctolagus cuniculus).
The male mediated teratogenic potential of a new antifertility compound, styrene maleic anhydride (SMA), was evaluated in rabbits. No teratogenic potential was observed at the doses of 1.25 mg, 2.5 mg and 5.0 mg used in our experiment.
Sethi
N
N
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Srivastava
R K
RK
Singh
R K
RK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008299:Maleic Anhydrides / Q000494:pharmacology*; D011137:Polystyrenes / Q000494:pharmacology*; D011247:Pregnancy / Q000187:drug effects; D011256:Pregnancy Outcome; D011817:Rabbits; D015430:Weight Gain / Q000187:drug effects
D003272:Contraceptive Agents, Male; D008299:Maleic Anhydrides; D011137:Polystyrenes; C025704:Styromal