Anticoagulant activity with dose-related response of glycoconjugates from bovine sublingual gland.
In this study we extracted glycoconjugates from bovine sublingual gland and attempted to investigate anticoagulant properties on blood coagulation of humans. To this purpose we performed the thromboelastographic technique and selective hemocoagulation screening tests. In particular, findings from screening tests indicated the occurrence of hemostatic effects on thrombin time (TT) and activated partial thromboplastin time (aPTT) with a response in a dose-related manner, whereas significant changes were not found on prothrombin time (PT).
Menghi
G
G
Dipartimento di Biologia Cellulare, Università di Camerino, Italy.
Piciotti
D
D
Luciani
S
S
Timperio
A M
AM
D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification; D001777:Blood Coagulation; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D006001:Glycoconjugates / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D013361:Sublingual Gland / Q000737:chemistry*
D000925:Anticoagulants; D006001:Glycoconjugates