Effect of murine recombinant interleukin-1 on brain oedema in the rat.
We investigated the effects of murine recombinant interleukin-1 (rIL-1, Du Pont) in vivo in the normal rat brain and here report both local and systemic effects of centrally administered rIL-1. Normal rats were given single or multiple atraumatic doses of either rIL-1 or and equal volume (5 microliters) of vehicle for control comparison. All dosages of intraparenchymal rIL-1 produced a uniform a hyperthermic response and concomitant lethargy. There was a related anorexia beyond fever duration. Histologic examination of intraparenchymal injection tracts revealed fibrillary whorls of oedema and a cellular infiltrate surrounding the rIL-1 tract, while similar changes were less prominent in control injection tracts. Repeated high doses of rIL-1 produced significantly higher concentrations of brain water as measured by the gravimetric technique. We conclude that rIL-1 is not only a potent chemoattractant, but is also an edigematic agent when administered in high doses.
Gordon
C R
CR
Division of Neurosurgery, Medical College of Virginia, Richmond.
Merchant
R S
RS
Marmarou
A
A
Rice
C D
CD
Marsh
J T
JT
Young
H F
HF
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins
D007375:Interleukin-1; D011994:Recombinant Proteins