title: [Result of 3 years of screening for preclinical phase of juvenile insulin-dependent diabetes mellitus].
abstract: We screened 1,000 individuals for pre-type I diabetes mellitus: 927 were first degree relatives of patients treated at our institution, 31 other had related autoimmune diseases, 42 had fortuitously discovered slight hyperglycemia. Islet cell antibodies were present in 31 subjects, 13 adults and 18 children. Among these 18 children, 7 also had complement-fixing islet cell antibodies, and 5 anti-insulin antibodies. All but one initially had a normal insulin response to intravenous glucose. The child with the abolished response, as well as another whose insulin secretion fell down during the study period, became diabetic. Based on these preliminary data, we are developing large scale family screening of pre-type I diabetes.
authors.affiliation: Service d'Endocrinologie Pédiatrique, U 342 de l'INSERM, Hôpital Saint-Vincent-de-Paul, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Lesage
authors.forename: C
authors.initials: C
authors.lastname: Boitard
authors.forename: J C
authors.initials: JC
authors.lastname: Carel
authors.forename: M
authors.initials: M
authors.lastname: Dauvergne
authors.forename: M
authors.initials: M
authors.lastname: Roger
authors.forename: J L
authors.initials: JL
authors.lastname: Chaussain
authors.forename: P F
authors.initials: PF
authors.lastname: Bougnères
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis; D007515:Islets of Langerhans / Q000276:immunology; D008403:Mass Screening; D011236:Prediabetic State / Q000276:immunology*
chemical_list: D000906:Antibodies; D001323:Autoantibodies; D007330:Insulin Antibodies
vernacular_title: Bilan de trois années de dépistage de la phase préclinique du diabète juvénile insulino-dépendant.