title: Effects of an oral fat load on some prothrombotic markers in coronary heart patients.
abstract: The Authors studied the effects of an oral fat load with saturated fats on some recently identified molecular markers in order to assess a change in clotting balance in a prothrombotic sense. The series consists of 30 female subjects (mean age 46 +/- 4 yrs) suffering from coronary heart disease in the chronic phase (previous myocardial infarction, angor). Each subjects was kept on a standard diet and without drugs influencing the lipid and clotting balance. A venous blood withdrawal was done after an overnight fasting and three hours after an oral fat load (butter g 1/kg). For each sample the plasma levels of triglycerides, total cholesterol (enzymatic method), beta-thromboglobulin, d-dimer and tissue plasminogen activator (immunoenzymatic ELISA Methods, Boehringer Mannheim) were determined. The oral fat load caused a significant increase in triglycerides (p less than 0.05), whereas total cholesterol values remained almost unchanged. The values of beta-thromboglobulin showed a significant (p less than 0.05) reduction, whereas the ones of D-dimer (D-D) and tissue plasminogen activator showed a slight but not significant increase. The results demonstrated that the oral fat load did not cause any hemostatic change in prothrombotic sense; moreover, a reduction of the platelet activation is notable, probably dependent on the consumption of endogenous heparin involved in the lipoproteinlipase release.
authors.affiliation: Institute of Medical Clinic I, University of Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ferlito
authors.forename: C
authors.initials: C
authors.lastname: Di Mauro
mesh_terms: D000328:Adult; D015415:Biomarkers; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D008055:Lipids