[The antiarrhythmic action of piracetam].
It was found that a drug of the nootropic nature piracetam possessing pronounced antihypoxic properties eliminates calcium chloride-induced disturbances of the cardiac rhythm and significantly raises the threshold of atrial fibrillation during electrical stimulation. The drug's antiarrhythmic effect is followed by a decrease of the rhythm rate and an increase of the contraction amplitude. The animals treated with piracetam in a dose when its antiarrhythmic effects (300 mg/kg) exhibited a decrease of the membrane potential of erythrocytes as compared with control. Similar effects occurred in the animals treated with lidocaine. It can be concluded that in certain types of arrhythmias the use of piracetam restores the normal rhythm of contractions that is perhaps connected with its positive influence on metabolic processes in the myocardium.
Samvelian
V M
VM
Malakian
M G
MG
Badzhinian
S A
SA
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D008012:Lidocaine / Q000494:pharmacology / Q000627:therapeutic use; D008051:Lipid Bilayers / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008567:Membranes, Artificial; D010743:Phospholipids / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010743:Phospholipids; D008012:Lidocaine; D010889:Piracetam
Nekotorye aspekty antiaritmicheskogo deĭstviia piratsetama.