title: [Cefixime treatment in different bacterial infections in the ENT region].
abstract: The clinical efficacy and tolerance of cefixime were evaluated in an open uncontrolled clinical trial including 37 patients suffering from ENT-infections. The MIC90 values of this new oral cephalosporin against gram-negative pathogens are less than 1 mg/l. The antibacterial activity of cefixime against gram-negative pathogens is stronger than that of other oral cephalosporins. Cefixime was administered for five to twelve days twice daily in a dose of 200 mg. In one patient the treatment with cefixime was discontinued after five days due to perioral dermatitis. In 33 of 36 patients cure or distinct improvement was observed after cefixime treatment, showing a clinical success rate of 91.7%. Causative organisms were isolated in 17 of 37 patients (47.2%). After the cefixime therapy the causative organisms were eradicated in 13 of 17 patients (76.5%). The tolerance of cefixime is comparable with that of other oral cephalosporins.
authors.affiliation: Klinik für Hals-Nasen-Ohrenheilkunde, Medizinische Universität, Lübeck, Germany.
authors.forename: W W
authors.initials: WW
authors.lastname: Schlenter
authors.forename: R
authors.initials: R
authors.lastname: Blessing
authors.forename: K
authors.initials: K
authors.lastname: Pelz
authors.forename: U
authors.initials: U
authors.lastname: Benner
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy; D020682:Cefixime; D002439:Cefotaxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*; D014069:Tonsillitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D020682:Cefixime; D002439:Cefotaxime
vernacular_title: Cefiximbehandlung bei verschiedenen bakteriellen Infektionen im HNO-Bereich.