Effects of 5-fluorouracil on cultured rabbit lens epithelial cells.
The effects of 5-fluorouracil (5-FU) on growth and F-actin structure were investigated in cultured rabbit lens epithelial cells. A dose-inhibition study showed that for its antiproliferative effect on cells, the ID50 of 5-FU is 0.6 mg/l. This is similar to the value reported for subconjunctival fibroblasts and corneal epithelial cells. 5-FU does not affect the F-actin structure of the cells. Although cataract formation by 5-FU has not been reported, susceptibility of the lens epithelial cells to 5-FU should be considered when treating glaucoma patients with this drug.
Yamamoto
T
T
W.K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor.
Soong
H K
HK
Lichter
P R
PR
D000199:Actins / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005456:Fluorescent Dyes; D005472:Fluorouracil / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008856:Microscopy, Fluorescence; D011817:Rabbits
D000199:Actins; D005456:Fluorescent Dyes; D005472:Fluorouracil