A role for T cells in the induction of airway hyperreactivity.
In this study we investigated a possible relationship of delayed type hypersensitivity (DTH), as a model for cellular IgE-independent immunity, with the induction of airway hyperreactivity. In PC1 (picryl chloride) sensitized BALB/c mice DTH-like lung infiltrates were found that were maximal 48 hr after intranasal hapten challenge. During the elicitation of this DTH-like reaction tracheal hyperreactivity to the cholinergic agonist carbachol could be detected from 2 hr after challenge with the homologous hapten and that was maximal after 48 hr.
Garssen
J
J
Department of Pharmacology, University of Utrecht, The Netherlands.
Van Loveren
H
H
Van der Vliet
H
H
Bot
H
H
Nijkamp
F P
FP
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006241:Haptens / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000473:pathology; D007114:Immunization; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010853:Picryl Chloride / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000209:etiology* / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology*; D014132:Trachea / Q000187:drug effects / Q000276:immunology
D006241:Haptens; D002217:Carbachol; D010853:Picryl Chloride