title: Determination of antitubercular drugs in human plasma by HPLC through direct injection.
abstract: A simple and efficient method is described for the direct determination of Isoniazide (INH) and Pyrazinamide (PZAm) in human plasma, based on reversed-phase HPLC. A number of other antitubercular drugs such as p-Aminosalycylic acid (PAS), Streptomycin (STM) and Ethambutol (ETH) and the major metabolites of the two investigated drugs, namely N-Monoacetylisoniazide (AcINH) and Pyrazinoic acid (PZAc), were shown not to interfere with the assay method. A potential application of the method to routine clinical monitoring of antitubercular drugs is discussed.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Bari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Altomare
authors.forename: A
authors.initials: A
authors.lastname: Carotti
authors.forename: S
authors.initials: S
authors.lastname: Cellamare
authors.forename: G
authors.initials: G
authors.lastname: Leogrande
authors.forename: D
authors.initials: D
authors.lastname: De Vito
mesh_terms: D000995:Antitubercular Agents / Q000097:blood*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D006801:Humans
chemical_list: D000995:Antitubercular Agents