title: Effect of dexamethasone on IL-1 and IL-3-LA release by unstimulated human mononuclear cells.
abstract: The effect of dexamethasone on the in vitro release of IL-1 and IL-3-LA by human unstimulated mononuclear cells was studied. The drug elicited a dose-dependent effect on the production of both interleukins. In addition, a time course effect of dexamethasone on IL-3-LA was demonstrated. It appeared after 5 min of incubation, reached a maximal level after 15 min, and remained at that level after 24 h. The drug also caused a dose-dependent inhibitory effect on the ability of human mononuclear cells to incorporate [3H] uridine. The inhibitory effect of dexamethasone on these interleukins may serve as a partial explanation of the susceptibility to infection in patients treated with corticosteroids.
authors.affiliation: Department of Medicine B, Golda Medical Center, Hasharon Hospital, Petah Tikva, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Djaldetti
authors.forename: P
authors.initials: P
authors.lastname: Fishman
authors.forename: V
authors.initials: V
authors.lastname: Shtatlender
authors.forename: B
authors.initials: B
authors.lastname: Sredni
authors.forename: M
authors.initials: M
authors.lastname: Djaldetti
mesh_terms: D003864:Depression, Chemical; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007375:Interleukin-1 / Q000493:pharmacokinetics*; D007377:Interleukin-3 / Q000493:pharmacokinetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D013997:Time Factors
chemical_list: D007375:Interleukin-1; D007377:Interleukin-3; D003907:Dexamethasone