[The effect of the oxime HI-6 on miosis induced by topical administration of sarin and VX in the rabbit eye].
Effect of oxime HI-6 to rabbit miosis induced by the topical sarin and VX administration is presented. It has been found that effects of both toxins are better antagonized by parenteral than by topical HI-6 administration. The sarin antagonizing effect was found more effective. It has been also confirmed that there was no significant difference concerning the oxime HI-6 effect when topically administered either as 2.5% hypertonic or isotonic solution. Opposite to PAM-2, HI-6 effect was better in parenteral and topical administration of isotonic solutions, and less effective in local administration of hypertonic solutions.
Macić
I
I
Institut za farmaciju, Vojnomedicinska Akademija.
Vojvodić
V
V
Knezević
D
D
Maksimović
M
M
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage / Q000494:pharmacology*; D015877:Miosis / Q000139:chemically induced* / Q000503:physiopathology; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000008:administration & dosage / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012524:Sarin / Q000633:toxicity*
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009946:Organothiophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D012524:Sarin; C009680:VX-agent; C022870:asoxime chloride
Delovanje oksima HI-6 na miozu oka kunića, izazvanu lokalnom primenom sarina i VX-a.