[A neuropharmacological study of a hydroxazine derivative].
Neuropharmacological studies with the compound 2-methyl, 3-phenyl, 3-methyltransxydroxasino-propiophenon hydrochloride with cipher PS1, were carried out on rats as well as follow-up of development of drug dependence after continuous usage of the substance. The obtained showed that the compound S1 had stimulating influence on the central nervous system of amphetamine-like type. After prolonged administration of amphetamine and the compound PS1 it was established in rats that amphetamine induced development of tolerance and occurrence of hypersensitivity during withdrawal. The compound PS1 did not cause similar changes in rats after its chronic administration.
Ilarionov
I
I
Bantutova
I
I
Iakimova
K
K
D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009448:Neurochemistry; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D019966:Substance-Related Disorders / Q000209:etiology
D000662:Amphetamines; D006834:Hydrazines; D011427:Propiophenones
Nevrofarmakologichno prouchvane na edno khidroksazinovo proizvodno.