A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy.
Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called "striosomes". In addition, a number of typical "woolly fibers" were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive "woolly fibers" appearance was less well recognizable in the GPe from all the PSP patients examined.
Matsumoto
S
S
Bluestone Laboratory, Division of Neuropathology, Montefiore Medical Center, Bronx, NY 10467.
Goto
S
S
Hirano
A
A
D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D004744:Enkephalin, Methionine / Q000032:analysis*; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D009928:Organ Specificity; D011699:Putamen / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*
D004744:Enkephalin, Methionine