[Effect of maternal virus-specific T-lymphocytes on pregnancy and fetal pathogenesis in experimental congenital influenza infection].
Inoculation of virus-specific cytotoxic lymphocytes (CTL) to pregnant mice infected with influenza virus was shown to result in a decrease of infectious virus concentration in the lungs and blood of mice as well as in the placentas and fetuses. With an increase in the dose of inoculated CTL, however, premature deliveries with stillbirths were observed as well as deaths of the mice, the highest frequency of fetal deaths being observed after infection of pregnant mice in the first half of pregnancy. It is not excluded that maternal virus-specific CTL played a role in the formation of developmental abnormalities and immunodeficient states in newborns.
Nefedova
N B
NB
Gordeeva
M S
MS
Zuev
V A
VA
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D016219:Immunotherapy, Adoptive; D009980:Influenza A virus / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000151:congenital / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000637:transplantation; D013997:Time Factors
Vliianie materinskikh virusspetsificheskikh T-limfotsitov na formirovanie patologii beremennosti i plodov pri éksperimental'noĭ vrozhdennoĭ grippoznoĭ infektsii.