Effect of subacute exposure to nitrogen dioxide on the airway responsiveness of guinea pig.
Subacute (7 days) exposure of guinea pigs to 4 ppm NO2 induces transient airway hyperresponsiveness to inhaled histamine (His)-aerosol as does acute exposure to higher concentration of NO2. Thromboxane A2 may play an important role in this transient airway hyperresponsiveness.
Kobayashi
T
T
Department of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Shinozaki
Y
Y
D000388:Air; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008689:Methacrylates / Q000494:pharmacology; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D013997:Time Factors
D008689:Methacrylates; D013930:Thromboxane-A Synthase; C034364:ozagrel; D009585:Nitrogen Dioxide