Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.
Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage. In contrast, ibuprofen or diclofenac, while also retaining anti-inflammatory activity, produced marked gastrointestinal irritancy as evidenced by mucosal damage and blood loss.
Melarange
R
R
SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
Gentry
C
C
O'Connell
C
C
Blower
P R
PR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D002074:Butanones / Q000008:administration & dosage* / Q000633:toxicity; D002351:Carrageenan; D004008:Diclofenac / Q000008:administration & dosage* / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000503:physiopathology / Q000517:prevention & control; D007052:Ibuprofen / Q000008:administration & dosage* / Q000633:toxicity; D008297:Male; D000077430:Nabumetone; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D004008:Diclofenac; D002351:Carrageenan; D000077430:Nabumetone; D007052:Ibuprofen