[Metabolism of cartilaginous tissues of rats under the effects of corticoids. Dose-dependent effect of the glycosaminoglycan-peptide complex].
The incorporation of labelled sulfate in knee articular cartilage and in xiphoid process cartilage was studied by autohistoradiography in the rat. Sulfate incorporation was decreased by the systemic administration of dexamethasone. A dose-dependent correction of this decrease was produced by the simultaneous administration of glycosaminoglycanes-peptides complex.
Annefeld
M
M
Robapharm SA, Bâle, Suisse.
D000818:Animals; D001345:Autoradiography; D002356:Cartilage / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000494:pharmacology*; D008297:Male; D010455:Peptides / Q000494:pharmacology; D011509:Proteoglycans / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism; D013462:Sulfur Radioisotopes
D006025:Glycosaminoglycans; D010455:Peptides; D011509:Proteoglycans; D013431:Sulfates; D013462:Sulfur Radioisotopes; D003907:Dexamethasone
Etude du métabolisme des tissus cartilagineux du rat sous l'action des corticoïdes. Effet dose-dépendant du complexe glycosaminoglycanes-peptides.