[Role of rat thymus chromatin lipids in response to the harmful effect of gamma-radiation].
In vitro incubation of thymocytes with [2-14C]acetate results in a more intensive label incorporation into chromatin lipids as compared to nuclear lipids. The deleterious effect of gamma-irradiation leads to specific changes in [2-14C]acetate incorporation into the total fraction of phosphatidylcholine-phosphatidylserine and chromatin sphingomyelin. This is paralleled with an increase in the ratio of specific radioactivities of chromatin cardiolipin and nuclear cardiolipin. The changes in specific radioactivities of sphingomyelin, phosphatidylcholine-phosphatidylserine and cardiolipin suggest a role of phospholipids in the mechanisms of regulating the activity of intranuclear structures.
Kulagina
T P
TP
Kolomiĭtseva
I K
IK
Kaznacheev
Iu S
IuS
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002784:Cholesterol / Q000032:analysis; D002843:Chromatin / Q000528:radiation effects*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000528:radiation effects*
D002843:Chromatin; D010743:Phospholipids; D002784:Cholesterol
Uchastie lipidov khromatina timotsitov krys v otvetnykh reaktsiiakh na povrezhdaiushchee vozdeĭstvie gamma-radiatsii.