title: Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems.
abstract: Most evaluations of the contributions of possible alterations in serotonergic neurotransmission to the etiology and treatment of neuropsychiatric disorders preceded the recent explosion of information regarding multiple serotonin (5-HT) receptors and brain 5-HT subsystems. This review provides an appraisal of some examples where drugs acting at different 5-HT receptor subtypes have provided new treatment or have contributed to the development of knowledge regarding various neuropsychiatric disorders, including anxiety, panic disorder, obsessive-compulsive disorder, depression, schizophrenia, alcoholism, migraine, sexual dysfunction, and Alzheimer's disease.
authors.affiliation: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892.
authors.forename: D L
authors.initials: DL
authors.lastname: Murphy
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin