title: Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications.
abstract: This review describes the microencapsulation of pharmaceuticals using the technique of emulsification-solvent evaporation. Guidelines are given for development of encapsulation processes for drugs with either high or low aqueous solubilities. Methods for microsphere characterization and assessment are detailed. The properties of a range of encapsulating polymers are described with examples of drugs encapsulated. The article concludes by speculating the clinical potential of microsphere-based drug delivery systems.
authors.affiliation: Department of Pharmaceutical Sciences, University of Nottingham, U.K.
authors.forename: P J
authors.initials: PJ
authors.lastname: Watts
authors.forename: M C
authors.initials: MC
authors.lastname: Davies
authors.forename: C D
authors.initials: CD
authors.lastname: Melia
mesh_terms: D000818:Animals; D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions; D006801:Humans; D008863:Microspheres; D012997:Solvents
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004655:Emulsions; D012997:Solvents