Transcellular transactivation by the human immunodeficiency virus type 1 tat protein.
The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.
Helland
D E
DE
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Welles
J L
JL
Caputo
A
A
Haseltine
W A
WA
D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D015696:Gene Products, tat / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D011233:Precipitin Tests; D011401:Promoter Regions, Genetic; D015533:Transcriptional Activation; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus