Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.
Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of both serotonin uptake sites in frontal cortex and dopamine uptake sites in striatum, suggesting serotonergic and dopaminergic axons terminals were compressed in the smaller brain volumes. The density of S2 serotonin receptors in MAM-lesioned frontal cortex was decreased probably due to down-regulation, while densities of D1 and D2 dopamine receptors in striatum were identical between MAM-lesioned rats and control rats.
Watanabe
M
M
Department of Psychiatry, National Defense Medical College, Saitama, Japan.
Kinuya
M
M
Mamiya
G
G
Tatsunuma
T
T
Nagayoshi
M
M
Matsutani
T
T
Tsukada
Y
Y
D000014:Abnormalities, Drug-Induced / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*; D012016:Reference Values; D012701:Serotonin / Q000378:metabolism*; D013723:Teratogens
D011985:Receptors, Serotonin; D013723:Teratogens; D012701:Serotonin; D008746:Methylazoxymethanol Acetate; C030667:methylazoxymethanol; D004298:Dopamine