Microalbuminuria is an early response following acute myocardial infarction.
Ninety-six patients admitted to two coronary care units with suspected acute myocardial infarction were studied. The diagnosis was confirmed in 44, the remaining 52 were used as a control group. The first urine passed after admission, together with early morning urines on the following 3 days, were saved in all patients. Urinary albumin and IgG were measured by automated immunoturbidimetry and expressed as the protein creatinine ratio in mg.mmol-1. The log mean (SD) albumin creatinine ratios for the first urine passed in the myocardial infarction and non-myocardial infarction patient groups were 6.2(4.2) and 1.3(3.4) respectively. The difference in log mean albumin creatinine ratio was 4.9 mg.mmol-1, 95% CI 3.4 to 6.2 mg.mmol-1; t = 6.127 df = 94, P less than 0.0001. The median IgG creatinine ratio for the first urine passed after admission in myocardial infarction patients was 1.0 mg.mmol-1 (95% CI 0.5 to 1.2) and for non-myocardial infarction patients 0.3 (95% CI 0.2 to 0.4). Increased urinary protein excretion appears to be an early and proportional response to acute myocardial infarction.
Gosling
P
P
Department of Biochemistry, Selly Oak Hospital, Birmingham, U.K.
Hughes
E A
EA
Reynolds
T M
TM
Fox
J P
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000209:etiology*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000652:urine*; D010539:Permeability; D011237:Predictive Value of Tests; D012044:Regression Analysis; D013997:Time Factors
D007074:Immunoglobulin G; D003404:Creatinine