Applications of integrated cell models: novel predictions on the behaviour of red cells and reticulocytes.
The power of mathematical cell models to predict novel behaviour concerned with the volume, pH and ion content regulation of red cells and reticulocytes is illustrated with three examples. Experimental results support the theoretical predictions.
Lew
V L
VL
Physiological Laboratory, Cambridge University, UK.
Freeman
C J
CJ
Ortiz
O E
OE
Bookchin
R M
RM
D000755:Anemia, Sickle Cell / Q000378:metabolism; D000818:Animals; D002412:Cations / Q000378:metabolism; D002463:Cell Membrane Permeability; D004912:Erythrocytes / Q000502:physiology*; D006451:Hemoglobin, Sickle / Q000502:physiology; D006801:Humans; D006982:Hypertonic Solutions; D008954:Models, Biological; D012156:Reticulocytes / Q000502:physiology*
D002412:Cations; D006451:Hemoglobin, Sickle; D006982:Hypertonic Solutions