title: [Variations of vasoactive intestinal peptide (VIP) concentration in the lung of asthmatic patients].
abstract: The vasoactive intestinal peptide (VIP) concentrations in the pulmonary and systemic arterial blood were evaluated in 11 asthmatic patients in symptom-free period and during methacholin induced broncospasm. The basal venous and arterial mean values do not significantly differ. A significant difference was observed after bronchial challenge. This could be caused by an increased VIP pulmonary production as a defensive mechanism. No correlation was found between bronchial reactivity (as PD20-FEV1 Methacholin) and VIP concentrations.
authors.affiliation: ISMI - Instituto Scientifico di Medicina Interna, Genova.
authors.forename: G
authors.initials: G
authors.lastname: Bottino
authors.forename: P
authors.initials: P
authors.lastname: Moscatelli
authors.forename: G
authors.initials: G
authors.lastname: Antgognozzi
authors.forename: R
authors.initials: R
authors.lastname: De Grandi
authors.forename: C
authors.initials: C
authors.lastname: Augeri
authors.forename: A
authors.initials: A
authors.lastname: Garfagnini
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
chemical_list: D014660:Vasoactive Intestinal Peptide
vernacular_title: Variazioni del peptide intestinale vasoattivo (VIP) nel passaggio attraverso il polmone nella malattia asmatica.