5-Hydroxytryptamine1A receptors and behavioral responses.
The special role of behavioral studies in attempting to understand the substrates for the psychotherapeutic actions of 5-hydroxytryptamine1A (5-HT1A)-selective agents, such as buspirone and other azapirones, is reviewed. The effects of buspirone and related drugs is discussed in three different types of behavioral studies: (1) unconditioned behaviors elicited by 5-HT agonists; (2) drug discrimination studies; and (3) conditioned behaviors that predict clinical drug effects. These studies have helped define important neuropharmacologic actions on 5-HT receptors that may contribute to therapeutic effects in anxiety and depression. Finally, critical problems for advancing our understanding of the association between 5-HT receptor subtypes and behavior are discussed.
Lucki
I
I
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-4283.
Wieland
S
S
D000818:Animals; D001519:Behavior / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D006801:Humans; D011985:Receptors, Serotonin / Q000502:physiology*
D011985:Receptors, Serotonin