title: Modulation of guinea pig airway reactivity by the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE).
abstract: The influence of the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE) on guinea pig tracheal reactivity to both contractile and relaxant agonists was investigated in vitro. 13-HODE induced an increased contraction of tracheal rings to histamine, whereas methacholine responsiveness was not significantly affected. Relaxant responses to isoprenaline and prostaglandin E2 were not influenced either.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Engels
authors.forename: P A
authors.initials: PA
authors.lastname: Henricks
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Linde
authors.forename: F P
authors.initials: FP
authors.lastname: Nijkamp
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008041:Linoleic Acids / Q000494:pharmacology*; D009119:Muscle Contraction; D014132:Trachea / Q000187:drug effects*
chemical_list: D008041:Linoleic Acids; C024348:13-hydroxy-9,11-octadecadienoic acid; D006632:Histamine