Metabolic control theory: the geometry of the triangle.
The definitions of flux control coefficients and elasticity coefficients as given in the Metabolic Control Theory are introduced by geometrical considerations. It is shown that a method to determine the (non-normalized) control coefficients from the elasticity coefficients as well as the well-known summation and connectivity relationships can easily be derived in a geometric way. This method is explained in the light of a simple example, but it can be applied to any metabolic system. A software implementation (program "control") and possible applications to biotechnology are briefly presented.
Mazat
J P
JP
IBCN-CNRS 1, Bordeaux, France.
Letellier
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Reder
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D001709:Biotechnology; D001711:Biotransformation; D003198:Computer Simulation; D004548:Elasticity; D008433:Mathematics; D008660:Metabolism; D008954:Models, Biological