Influence of muramyl dipeptide on established experimental arthritis in rats.
The effects of MDP, a potent inducer of cytokines, were studied in four batches of Wistar Furth rats with established experimental arthritis. Arthritic rats were given a daily sc injection of 10, 100, 200 or 400 micrograms MDP respectively. Muramyl dipeptide increased the severity of clinical events in a dose-dependent manner, with the exception of the 10 micrograms dose which was ineffective. The levels of anti-collagen antibodies were not however significantly enhanced by MDP. Radiological lesions and histological changes were maximal at high dosage regimens. Paradoxically, the acute phase reactive alpha 1 glycoprotein was little affected by MDP treatment.
Jouzeau
J Y
JY
Department of Pharmacology, URA CNRS 1288, Nancy.
Drelon
E
E
Gillet
P
P
Bannwarth
B
B
Fener
P
P
Charrière
G
G
Payan
E
E
Chauvelot-Moachon
L
L
Batt
A M
AM
Floquet
J
J
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D011859:Radiography; D051381:Rats; D011920:Rats, Inbred WF
D006023:Glycoproteins; D007074:Immunoglobulin G; D000119:Acetylmuramyl-Alanyl-Isoglutamine