Modulation of zoxazolamine metabolism in carrageenan-induced inflammation in rats.
In male rats bearing carrageenan-induced paw edema twenty-four hours after treatment with carrageenan the duration of hexobarbital hypnosis was prolonged and the rate of hepatic hexobarbital metabolism was inhibited. By contrast, treatment with carrageenan potentiates zoxazolamine paralysis time and inhibits zoxazolamine metabolism in both male and female rats. Thus, sex-related differences in the rats bearing carrageenan-induced paw edema and inhibition of drug metabolism are apparently substrate dependent.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Sasaki
K
K
Yakayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002351:Carrageenan / Q000633:toxicity*; D004487:Edema / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D005528:Foot; D006591:Hexobarbital / Q000378:metabolism; D008297:Male; D010243:Paralysis / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013997:Time Factors; D015049:Zoxazolamine / Q000009:adverse effects / Q000378:metabolism*
D002351:Carrageenan; D015049:Zoxazolamine; D006591:Hexobarbital