title: Three-dimensional display of myocardial perfusion: detection of ischemic lesions using a new image subtraction method.
abstract: A recent, commercially available computer program for the three-dimensional (3D) display of single-photon emission tomography (SPET) data was used to study myocardial perfusion in patients with coronary artery disease (CAD). To enable the detection of small ischemic lesions, the authors proposed a new "distance-substraction" method: after suitable centering of the axial slices, 3D "distance-shaded" images of the stress study were subtracted from the corresponding views of the rest study. With this technique, small changes in surface-to-observer distance were highlighted, thus enabling us to detect nontransmural ischemic areas of the myocardium. General characteristics and possibilities of the subtraction technique were tested on a simple myocardial phantom. Some clinical results of the application of this method on CAD patients are presented and discussed. In CAD patients in whom only nontransmural ischemic lesions are present, the subtraction of "distance-shaded" images is decisive for a correct diagnosis.
authors.affiliation: Servizio di Fisica Sanitaria, Arcispedale S. Maria Nuova, USL, Reggio Emilia, Italy.
authors.forename: P P
authors.initials: PP
authors.lastname: Ferretti
authors.forename: G
authors.initials: G
authors.lastname: Borasi
authors.forename: D
authors.initials: D
authors.lastname: Salvo
authors.forename: D
authors.initials: D
authors.lastname: Serafini
authors.forename: A
authors.initials: A
authors.lastname: Versari
mesh_terms: D003287:Contrast Media; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D015609:Organotechnetium Compounds; D013382:Subtraction Technique; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003287:Contrast Media; D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi