[The sensitivity of a Plasmodium berghei strain resistant to artemisinin and other antimalarial preparations].
The development of P. berghei resistance to artemisin has been studied. The NArRs P. berghei strain which has 200 times lower sensitivity to artemisin was formed. Different degree cross-resistance was established with quinine, chloroquine, dabequine, mefloquine; a high fansidar's efficacy in respect to NArRs was observed.
Fedorova
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D000818:Animals; D000962:Antimalarials / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D037621:Artemisinins; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects*; D012692:Serial Passage; D012717:Sesquiterpenes / Q000037:antagonists & inhibitors* / Q000627:therapeutic use
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin
Chuvstvitel'nost' shtamma Plasmodium berghei, ustoĭchivogo k artemizininu i drugim protivomaliariĭnym preparatam.