5-Fluorouracil derivatives. XX. Synthesis and antitumor activity of 5'-O-unsaturated acyl-5-fluorouridines.
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-pentenoyl derivative showed the highest antitumor activity.
Ozaki
S
S
Department of Resources Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Akiyama
T
T
Morita
T
T
Kumegawa
M
M
Nagase
T
T
Uehara
N
N
Hoshi
A
A
D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000970:Antineoplastic Agents; D005472:Fluorouracil