[Changes in the aminopeptidase activity in the brain neurons of rats subjected long-term to alcoholic intoxication].
A histochemical investigation was made of aminopeptidase activities using L-leucine-beta-naphthylamide and D, L-alanine-beta-naphthylamine as respective substrates in the rat's sensomotor cortex neurons during the period of ethanol withdrawal after a prolonged alcohol intoxication. Alcohol intoxication of the rat continued for 8 months. Different dynamics of aminopeptidase activities was shown depending on the substrate used during ethanol withdrawal. The results are discussed from the point of view of the existence of multiple forms of aminopeptidase in the brain and of their involvement in protein metabolism in pathological states.
Kazakova
O M
OM
Khokhrina
N T
NT
Uzbekov
M G
MG
D000409:Alanine / Q000031:analogs & derivatives / Q000378:metabolism; D000437:Alcoholism / Q000201:enzymology*; D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D006651:Histocytochemistry; D007930:Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D009044:Motor Cortex / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D013379:Substrate Specificity; D013997:Time Factors
C028104:alanine-beta-naphthylamide; C040135:leucine-beta-naphthylamide; D000626:Aminopeptidases; D007930:Leucine; D000409:Alanine
Izmenenie aktivnosti aminopeptidaz v neĭronakh golovnogo mozga krys, dlitel'no podvergavshikhsia alkogol'noĭ intoksikatsii.