Mechanocardiographic effects of ACE-inhibitors.
Twenty-one subjects who suffered a recent medium sized anterior myocardial infarction conditioning a mild congestive heart failure were randomly allocated to treatment with captopril (25 mg b.i.d., 10 pts) or placebo (11 pts). After 2 months of therapy the group on the active treatment showed a significant increase of apexcardiographic protodiastolic filling period duration reflecting a clear cut decrease of mean pulmonary capillary wedge pressure (from 14 +/- 2 to 7 +/- 3 mm Hg) while patients on placebo did not show any difference in respect to baseline. Neither treatment significantly modified the PEP/LVET ratio despite a significant increase of left ventricular ejection fraction in patients receiving captopril (from 37 +/- 4% to 43 +/- 5%). Cardiac response to ACE-inhibitors can thus be noninvasively monitored by apexcardiography.
Mortarino
G
G
Cardiac Rehabilitation Department, Ospedale di Cuasso al Monte, Italy.
Ghiringhelli
S
S
Onofri
M
M
Trudu
A
A
Corda
G
G
Lepori
G
G
D002216:Captopril / Q000627:therapeutic use*; D002339:Carotid Arteries / Q000503:physiopathology; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007702:Kinetocardiography; D008297:Male; D008875:Middle Aged; D010701:Phonocardiography; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects
D002216:Captopril