Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity.
Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor (protein kinase C) may be involved in the increased renal vascular resistance associated with cyclosporine A-induced nephrotoxicity.
Nambi
P
P
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
Pullen
M
M
Wu
H L
HL
Brooks
D P
DP
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003524:Cyclosporins / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000378:metabolism*; D014655:Vascular Resistance
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003524:Cyclosporins; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D011493:Protein Kinase C