Hb Fukutomi [alpha 126(H9)Asp----Val]: a new hemoglobin variant with high oxygen affinity.
Hb Fukutomi [alpha 126(H9)Asp----Val], a new hemoglobin variant with a high affinity for oxygen (log P50 = 0.201 at pH 7.0, normal = 1.087) was detected in a Japanese male during a screening survey. The amino acid substitution is located in the alpha 1 beta 1 contact of the tetramic molecule. Like other variants of the high oxygen affinity type Hb Fukutomi showed increased resistance to auto-oxidation. The tryptic peptide alpha T-13, that usually forms part of the trypsin-resistant core of the alpha chain, was cleaved off by trypsin in the new variant and released into the soluble fraction.
Hidaka
K
K
Department of Biochemistry, Kawasaki Medical School, Kurashiki, Japan.
Iuchi
I
I
Kobayashi
T
T
Katoh
K
K
Yaguchi
K
K
D000595:Amino Acid Sequence; D006455:Hemoglobins, Abnormal / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood; D011485:Protein Binding
D006455:Hemoglobins, Abnormal; C067964:hemoglobin Fukutomi; D010100:Oxygen