A re-evaluation of the HSA-piroxicam interaction.
Piroxicam binding to HSA was studied using equilibrium dialysis and fluorescence methods. It was shown that this drug, like its analogs isoxicam and tenoxicam, binds to the apazone locus (site I area) and to a lesser extent to the diazepam site (site II). The piroxicam binding to HSA can be modulated by various specific ligands--apazone, warfarin, diazepam, ibuprofen--and these drug interactions have to be considered not only as potential displacement from the HSA binding sites but also in terms of induced allosteric effects.
Brée
F
F
Service Hospitalo-Universitaire de Pharmacologie, Faculté de Médecine, Creteil, France.
Urien
S
S
Nguyen
P
P
Riant
P
P
Albengres
E
E
Tillement
J P
JP
D001032:Apazone / Q000378:metabolism; D001665:Binding Sites; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D010894:Piroxicam / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D010894:Piroxicam; D001032:Apazone; D003975:Diazepam; D007052:Ibuprofen