The effects of long-term using once-a-month injectable contraceptive norethisterone enanthate/estradiol valerate on coagulation in the Chinese.
Sixty-four Chinese women were studied for the effects of injecting once-a-month contraceptive norethisterone enanthate/estradiol valerate between 2 to 4 1/2 years on certain coagulation and fibrinolytic parameters, and 59 women not receiving any steroidal contraception were controls. In both groups there was no significant change in PT, fibrinogen, factor X activity, AT III antigen, AT III activity and fibrinolytic activity expressed by euglobulin lysis time. There was no significant difference in mean levels of factor VIIIR:Ag between the two groups, although a sub-group women in treatment group had higher than accepted levels of factor VIIIR:Ag.
Meng
Y X
YX
WHO Clinical Collaborating Center for Research in Human Reproduction, Zhejiang Academy of Medical Sciences, Hangzhou, People's Republic of China.
Jiang
H Y
HY
Lu
F Y
FY
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D002681:China; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007267:Injections; D008137:Longitudinal Studies; D009640:Norethindrone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012307:Risk Factors
D003271:Contraceptive Agents, Female; D004958:Estradiol; C024319:norethindrone enanthate; D009640:Norethindrone