[Localized thoracic neuroblastoma: the role of surgery and therapeutic results. Apropos of 40 cases].
From 1982 to 1987, forty children with non-metastatic thoracic neuroblastoma were treated with a same therapeutic regimen. According to TNM staging, there were II CS I, 19 CS II and 10 CS III. All patients underwent surgery; thirty had primary surgical excision; in ten whose tumor were deemed uresectable, surgery was delayed until after a trial of chemotherapy. Operation was completed by several courses of chemotherapy in case of microscomic residual disease or lymph node involvement; radiotherapy was delivered in case of gross residual disease. Using this therapeutic approach. Event Free Survival is 92% with a median follow up of 40 months. Severe complications were rare and sequellae appear to be related to the disease i.e. neurologic consequence of cord compression.
Rubie
H
H
Service de Médecine Infantile B, CHU Purpan, Toulouse.
Hartmann
O
O
Giron
A
A
Lemoine
G
G
Guitard
J
J
Robert
A
A
Lemerle
J
J
D000008:Abdominal Neoplasms / Q000473:pathology / Q000601:surgery; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*
Neuroblastomes thoraciques localisées: place de la chirurgie et résultats thérapeutiques. A propos de 40 cas.