title: Fine structure of calcitonin gene-related peptide-immunoreactive nerve fibres in the rat temporomandibular joint.
abstract: The distribution and fine structure of these nerve fibres was examined by immunoelectron microscopy. CGRP-immunoreactive fibres were seen in the nerve bundles, blood vessels and periosteum around the condyle as well as in the disc. These nerve fibres were unmyelinated and had diameters varying from 200 to 600 nm. They were completely or partially enclosed by Schwann cell cytoplasm and did not form synaptic contact with any cells. CGRP-immunoreactive nerve fibres may be sensory nature and this peptide could be involved in pain transmission and neurogenic inflammation.
authors.affiliation: First Department of Oral Anatomy, Osaka University, Faculty of Dentistry, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Wakisaka
authors.forename: M
authors.initials: M
authors.lastname: Akai
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D015740:Calcitonin Gene-Related Peptide; D003094:Collagen; D003238:Connective Tissue / Q000294:innervation; D003593:Cytoplasm / Q000648:ultrastructure; D008335:Mandibular Condyle / Q000294:innervation; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000648:ultrastructure*; D010521:Periosteum / Q000294:innervation; D051381:Rats; D012583:Schwann Cells / Q000648:ultrastructure; D013704:Temporomandibular Joint / Q000098:blood supply / Q000294:innervation*
chemical_list: D003094:Collagen; D015740:Calcitonin Gene-Related Peptide