Effect of malathion on the initiation and elongation steps of transcription.
In isolated cell nuclei of pig thymus malathion, S-1,2-bis(ethoxycarbonyl)-ethyl-O,O-dimethyldithiophosphate inhibited both initiation and elongation of all three classes of nuclear RNA polymerases; proflavin was used as an inhibitor of initiation, and actinomycin, as an inhibitor of elongation.
Walter
Z
Z
Department of Molecular Genetics, University of Lódź, Poland.
Wiszkowska
H
H
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D007700:Kinetics; D008294:Malathion / Q000494:pharmacology*; D011370:Proflavine / Q000494:pharmacology; D013552:Swine; D013950:Thymus Gland / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*
D003609:Dactinomycin; D011370:Proflavine; D008294:Malathion