[Action of antioxidants on membrane-toxic effects of anticholinesterase agents].
It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate. Thus, antioxidants are pathogenetic drugs for treatment of poisonings with cholinesterase inhibitors.
Zatsepin
E P
EP
Churaev
N N
NN
Uspenskaia
T A
TA
Tirzit
G D
GD
Dubur
G Ia
GIa
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004095:Dihydropyridines / Q000494:pharmacology / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008294:Malathion / Q000506:poisoning; D008297:Male; D051379:Mice; D051381:Rats
D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D004095:Dihydropyridines; D008294:Malathion
Vliianie antioksidantov na membranotoksicheskie éffekty antikholinésteraznykh sredstv.