title: Echocardiographic changes in patients with heterozygous and homozygous familial hypercholesterolemia: correlation with clinical findings.
abstract: 59 heterozygous and 6 homozygous patients with familial hyperchole sterolemia were screened for atherosclerosis of the aortic root and cardiac valves by echocardiography. Pathological echocardiographic changes were found in 59% of heterozygotes and in all homozygotes. In heterozygotes, aortic root sclerosis usually appears after the age of 30 and its frequency increases progressively with age. Homozygotes showed severe changes before the age of 10. In heterozygotes, a pathological echocardiogram correlated strongly with the presence of overt coronary heart disease. Echocardiography proved to be a useful non-invasive method for better evaluation of the individual coronary risk in patients with familial hypercholesterolemia.
authors.affiliation: Medizinische Poliklinik, Universität München.
authors.forename: F
authors.initials: F
authors.lastname: Tatò
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.forename: S
authors.initials: S
authors.lastname: Schewe
authors.forename: W
authors.initials: W
authors.lastname: Pinter
authors.forename: G
authors.initials: G
authors.lastname: Wolfram
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000235:genetics; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000235:genetics; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000000981:diagnostic imaging* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol