Chronic myelocytic leukaemia with unusual (27 years) complete remission terminating in acute undifferentiated leukaemia: a clinical and karyotypic study.
A case of clinically typical CML (300 x 10(6)/l leukocytes, 400 x 10(6)/l platelets, splenomegaly) is presented. After complete remission induced by busulphan, no clinical or haematological abnormalities were observed for 27 years until the development of acute leukaemia (type M1), which was rapidly fatal after a brief chemotherapy-induced remission. The cytogenetic findings were also original: no chromosome Ph1 (during remission 3 years after the onset of the disease), no translocation (banding study 5 years later), and no bcr/abl rearrangement (during the terminal phase).
Najean
Y
Y
Department of Nuclear Medicine, Hospital Saint-Louis, Paris, France.
Miclea
M
M
Tanzer
J
J
Lessard
M
M
Sigaux
F
F
D002066:Busulfan / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D013997:Time Factors
D002066:Busulfan