title: [Diffuse noxious inhibitory controls: theoretical aspects applied to the effects of regional administration of morphine].
abstract: Assuming a relatively high background activity of convergent neurons, we have suggested that their pain-signalling message could consist in the contrast between the high rate of firing in the segmental neuronal pool induced by the painful focus and the D.N.I.C.-mediated silence of the remaining neuronal population. This notion is substantiated by several observations in the rat regarding morphine analgesia: a clear lifting of D.N.I.C. is observed following systemic (0.1-1 mg/kg; i.v.), intraventricular (0.6-2.5 micrograms) or intrathecal (15 micrograms) morphine. All these procedures could restore the initial level of background activity, analgesia resulting from the attenuation of the postulated contrast.
authors.affiliation: Unité de Recherches de Physiopharmacologie du Système Nerveux de l'INSERM (U. 161), Paris.
authors.forename: D
authors.initials: D
authors.lastname: Le Bars
authors.forename: D
authors.initials: D
authors.lastname: Bouhassira
authors.forename: L
authors.initials: L
authors.lastname: Villanueva
mesh_terms: D000818:Animals; D006801:Humans; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009433:Neural Inhibition; D009619:Nociceptors / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*; D012018:Reflex / Q000502:physiology*
chemical_list: D009020:Morphine
vernacular_title: Les contrôles inhibiteurs diffus induits par stimulations nociceptives (CIDN): aspects théoriques appliqués aux effets de l'administration régionale de morphine.