title: Intragastric device for weight loss. Effect on energy intake in dogs.
abstract: It remains unclear whether or not intragastric devices promote weight loss. To elucidate if an intragastric balloon reduces energy intake by a placebo effect of inducing satiety, five free-feeding dogs had balloons inserted via a gastric cannula. Meal intake was assessed with the balloons inflated to 200 and 500 ml with saline and compared with intake during a control period when the animals maintained stable weight. Average energy intake during the control period was 0.3 MJ/kg/day. Inflation to 200 ml had no significant effect on intake (0.31 MJ/kg/day), whereas inflation to 500 ml significantly reduced energy intake to 0.14 MJ/kg/day (P less than 0.0001). An intragastric balloon does create aversion to feeding, presumably by producing satiety, but the effect is volume dependent.
authors.affiliation: University Department of Surgery, Manchester Royal Infirmary, UK.
authors.forename: D
authors.initials: D
authors.lastname: Durrans
authors.forename: T V
authors.initials: TV
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Holt
mesh_terms: D000818:Animals; D004285:Dogs; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D015905:Gastric Balloon; D008297:Male; D008991:Monitoring, Physiologic; D010418:Pentagastrin / Q000494:pharmacology; D012528:Satiety Response / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*
chemical_list: D010418:Pentagastrin