title: [Comparative study of the toxicity of cyanic derivatives and/or aromatic amides].
abstract: The toxical potentiality of the cyanic radicle and the detoxicating characteristic of the amide group are studied following the evolution of the benzonitrile and benzamide toxicity when a cyanic or amide radicle is added to the original molecule. This comparative study shows that the presence of amide group has not always given a higher toxicity to the organic molecules that own it. It is the respective localization of the cyanic or amide radicles which appears to play the most important role.
authors.affiliation: Laboratoire de Pharmacologie, UFR de Pharmacie, Tours.
authors.forename: S L
authors.initials: SL
authors.lastname: Cheav
authors.forename: O
authors.initials: O
authors.lastname: Foussard-Blanpin
mesh_terms: D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D051379:Mice; D009570:Nitriles / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D001549:Benzamides; D009570:Nitriles; C014356:benzonitrile
vernacular_title: Etude comparée de la toxicité de dérivés cyanés et/ou amides aromatiques.