[Biotransformation of the anticholinesterase agent, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine].
Biotransformation of the anticholinesterasic agent 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine was studied in the laboratory rat. In the animal urine, the main identified metabolites were 9-amino-7-hydroxy-1,2,3,4-tetrahydroacridine and its conjugate with glucuronic acid, or sulfuric acid, as well as 9-amino-1-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine and 9-amino-2-hydroxy-7-methoxy-1,2,3,4-tetrahydroacridine. A part of the drug was excreted in an unchanged form.
Patocka
J
J
Vojenská lékarská akademie J.E. Purkynĕ, Hradec Králové.
Bielavský
J
J
D000818:Animals; D001711:Biotransformation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013619:Tacrine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D013619:Tacrine; C016222:7-methoxytacrine
Biotransformacní studie anticholinesterazika 9-amino-7-methoxy-1,2,3,4-tetrahydroakridinu.