title: Potentiation of cisplatin lethality by bacterial lipopolysaccharide pretreatment in mice.
abstract: The present study was designed to determine whether bacterial endotoxin (LPS) affects the lethality of cisplatin. Mice treated with LPS (1 mg/kg, i.p.) 24 hr and 1 hr before cisplatin had markedly increased the lethality and nephrotoxicity of cisplatin.
authors.affiliation: Department of Pharmacology & Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: R
authors.initials: R
authors.lastname: Ohzeki
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011292:Premedication
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; D002945:Cisplatin