Cardiovascular effect of skimmianine in rats.
Skimmianine, a general component contained in the plants of Rutaceae, was found to have a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats. A similar inhibitory action was also observed in the isolated atria. Moreover, skimmianine produced a nonspecific blockade of the cardiovascular functions at higher concentration.
Cheng
J T
JT
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, Republic of China.
Chang
S S
SS
Chen
I S
IS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology
D011804:Quinolines; D012701:Serotonin; C035932:skimmianine; D009638:Norepinephrine