Design of enzyme inhibitors using iterative protein crystallographic analysis.
Appelt
K
K
Agouron Pharmaceuticals, Inc., La Jolla, California 92037.
Bacquet
R J
RJ
Bartlett
C A
CA
Booth
C L
CL
Freer
S T
ST
Fuhry
M A
MA
Gehring
M R
MR
Herrmann
S M
SM
Howland
E F
EF
Janson
C A
CA
D003461:Crystallography; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D013940:Thymidylate Synthase