[The effect of x-ray irradiation on the cytochrome P-450-dependent mono-oxygenase system of the liver in different animal species].
The whole X-irradiation (7 Gy) of male rat, mouse and guinea-pig caused in general similar alterations in the content of cytochrome P-450 and aminopyrine-N-demethylase activity in liver microsomes. On the 5-7th day after irradiation the parameters were 39-79% of the normal level. The same postradiation changes were observed in females of these animal species but in females of rats and guinea-pigs the effect was less expressed. The depression of activity in liver microsomal cytochrome P-450-dependent monooxygenase system has been concluded to be one of the characteristic features of acute form in radiation damage.
Akhalaia
M Ia
MIa
Deev
L I
LI
Platonov
A G
AG
Khakimov
A
A
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology / Q000528:radiation effects*; D010105:Oxygenases / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013997:Time Factors; D014916:Whole-Body Irradiation
D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
Vliianie rentgenovskogo oblucheniia na tsitokhrom P-450-zavisimuiu monooksigenaznuiu sistemu pecheni u razlichnykh vidov zhivotnykh.