title: [The characteristics of the development in houseflies of resistance to synergized and nonsynergized permethrin].
abstract: Peculiarities of the development of room fly resistance during selection with permetrine have been studied in the laboratory conditions. A strain possessing a 50-fold level of resistance to permetrine has been obtained. A range of cross-resistance of this strain to insecticides of various chemical classes has been determined. It has been established that the basic mechanism regulating resistance to permetrine is an increase in cytochrome P-450 monooxygenases. Resistance can be overcome using a mixture consisting of permetrine and monooxygenase inhibitor piperonylbutoxide. The mixture retains its efficacy in almost 20 generations; later on the development of resistance to the mixture is accompanied by an increase in the level of resistance to nonsynergized piretroides and other preparations.
authors.forename: T A
authors.initials: TA
authors.lastname: Pereguda
authors.forename: T M
authors.initials: TM
authors.lastname: Agashkova
mesh_terms: D000818:Animals; D004351:Drug Resistance; D004357:Drug Synergism; D006793:Houseflies; D007306:Insecticides; D026023:Permethrin; D011722:Pyrethrins
chemical_list: D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin
vernacular_title: Osobennosti razvitiia rezistentnosti komnatnykh mukh k sinergizirovannomu i nesinergizirovannomu permetrinu.