[CDP-choline improves the postoperative rehabilitation of patients with cerebral risk].
To evaluate the efficacy of CDP-choline to prevent from brain damages after surgery for high risk patients, 210 patients receiving pre and post operative parenteral CDP-choline were compared to 204 controls (mean age 73 years) in a multicenter open randomised study. Quality and delay of anesthetic recovery were assessed. Cognitive screening test and self-control scale (simplified Mini Mental Status test and Barthel Index) were performed the day before and the first and fourth day after surgery. CDP-choline does not enhance quality or delay of anesthetic recovery but increases the percentage of subjects with a better fourth post-operative than preoperative cognitive and self-control test (p less than 0.05).
Bricourt
M O
MO
Département d'anesthésie-réanimation, Hôpital Corentin-Celton, Issy-les-Moulineaux.
Ghnassia
M D
MD
Legout-Montdargent
V
V
D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D012307:Risk Factors
D003566:Cytidine Diphosphate Choline
Amélioration par la CDP-choline de la récupération post-opératoire de sujets à risque cérébral.