[Evaluation of hematopoietic and stromal cells-precursors in children with neutropenia].
The content of hemopoietic and stromal precursor-cells was studied in the bone marrow of 46 children with congenital neutropenia and of 2 children with chronic benign neutropenia. It was found that the number of GM-CFC and F-CFC in the bone marrow of patients with chronic benign neutropenia did not differ from that in the control group of normal children, and the lowering of the neutrophil number in the blood was, probably, associated with their redistribution mechanism or increased destruction in the body. Multiple defects of hemopoietic and stromal tissue were detected in children with a hereditary form of congenital neutropenia when anomalous proliferation of F-CFC and disorders in GM-CFC differentiation led to hypoplasia of granulocytic growth stem and neutropenia.
Gerasimova
L P
LP
Kisliak
N S
NS
Mamedova
E A
EA
Finogenova
N A
NA
D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D009503:Neutropenia / Q000097:blood* / Q000151:congenital / Q000473:pathology; D009504:Neutrophils / Q000473:pathology*
Otsenka krovetvornykh i stromal'nykh kletok-predshestvennikov pri neĭtropeniiakh u deteĭ.