[Reduction of reactivity to allergic rhinitis with intravenous administration of calcium. Clinical-experimental study on the effect of changes of local airway resistance after nasal allergen provocation].
The antiallergic activity of calcium was investigated in 25 patients with allergic rhinitis by nasal provocation with increasing doses of phleum pratense during a symptom free interval. Prior to that provocation, the patients received 9 mmol calcium (Calcium-Sandoz) i.v. or placebo respectively (double blind cross-over design). The concentration of serum calcium increased after calcium injection by 0.45 +/- 0.055 mmol/l. Calcium exerted a significant protective effect as compared to placebo: higher allergen doses, (p = 0.021) i.e. 20433 biological units/ml vs. 7494 biological units/ml, were required in order to induce a defined allergic reaction (50% decrease of nasal air flow). The data thus furnish evidence that intravenous calcium reduces the allergic response in type I allergy.
Bachert
C
C
Klinikum Mannheim Universität Heidelberg.
Drechsler
S
S
Keilmann
A
A
Seifert
E
E
Schmidt
R
R
Welzel
D
D
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D002118:Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000503:physiopathology
D002118:Calcium
Verminderung der Reaktivität bei Rhinitis allergica durch intravenöse Applikation von Kalzium. Klinisch-experimentelle Studie über die Beeinflussung des Atemwegswiderstandes nach nasaler Allergen-Provokation.