title: A refined physical map of the long arm of human chromosome 16.
abstract: Mapping of 33 anonymous DNA probes and 12 genes to the long arm of chromosome 16 was achieved by the use of 14 mouse/human hybrid cell lines and the fragile site FRA16B. Two of the hybrid cell lines contained overlapping interstitial deletions in bands q21 and q22.1. The localization of the 12 genes has been refined. The breakpoints present in the hybrids, in conjunction with the fragile site, can potentially divide the long arm of chromosome 16 into 16 regions. However, this was reduced to 14 regions because in two instances there were no probes or genes that mapped between pairs of breakpoints.
authors.affiliation: Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, South Australia.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Chen
authors.forename: P C
authors.initials: PC
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Apostolou
authors.forename: E
authors.initials: E
authors.lastname: Baker
authors.forename: K
authors.initials: K
authors.lastname: Holman
authors.forename: S A
authors.initials: SA
authors.lastname: Lane
authors.forename: J K
authors.initials: JK
authors.lastname: Nancarrow
authors.forename: S A
authors.initials: SA
authors.lastname: Whitmore
authors.forename: R L
authors.initials: RL
authors.lastname: Stallings
authors.forename: C E
authors.initials: CE
authors.lastname: Hildebrand
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D015342:DNA Probes / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization
chemical_list: D015342:DNA Probes