The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients.
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.
Dmoszyńska-Giannopoulou
A
A
Department of Haematology and Nephrology, Medical School, Lublin, Poland.
Janicka
L
L
Sokołowska
B
B
Ksiazek
A
A
Orłowska
G
G
Janicki
K
K
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D006435:Renal Dialysis; D013442:Sulfinpyrazone / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D014810:Vitamin E; D013442:Sulfinpyrazone