[Comparison of the value of serum caffeine and bile acid concentrations as indicators of liver injury].
In 56 patients with various liver diseases and in 15 healthy controls fasting serum concentrations of caffeine (HPLC method) and total endogenous bile acids (enzymatic-spectrophotometric assay) were determined. Serum caffeine concentrations were significantly higher in patients with chronic hepatitis or liver cirrhosis than in controls but no differences was found between patients with obstructive jaundice and controls. Contrary to caffeine, fasting serum bile acids concentrations were higher in all patients groups than in controls. In all studied groups there was no correlation between caffeine and serum bile acids estimations. In patients with liver cirrhosis there was correlation between caffeine test and the Child's classification score. However, no correlation existed between the Child's classification and the serum bile acids concentration. Our data suggest that fasting serum caffeine concentration is more usefull indicator of liver injury than determination of total endogenous serum bile acids.
Habior
A
A
Kliniki Gastroenterologii i Przemiany Materii Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Ostrowski
J
J
Trzeciak
L
L
Wojciechowski
K
K
D000328:Adult; D001647:Bile Acids and Salts / Q000097:blood*; D002110:Caffeine / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged
D001647:Bile Acids and Salts; D002110:Caffeine
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