title: Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
abstract: Intravesical instillation of 2-phenyl-1,4-benzoquinone (PBQ), a metabolite of sodium o-phenylphenate (Na-OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor-initiating activity was observed with either Na-OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na-OPP urinary bladder carcinogenesis.
authors.affiliation: Division of Pathology, National Institute of Hygienic Sciences, Tokyo.
authors.forename: R
authors.initials: R
authors.lastname: Hasegawa
authors.forename: F
authors.initials: F
authors.lastname: Furukawa
authors.forename: K
authors.initials: K
authors.lastname: Toyoda
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D001713:Biphenyl Compounds; C004369:2-phenylphenol