Anticardiolipin syndrome in childhood: a report of two cases.
We describe two children with an otherwise unexplained deep vein thrombosis associated with high titer anticardiolipin antibodies (ACA) of the IgG class and circulating lupus anticoagulant (LAC). One of these patients had persistent proteinuria but neither had systemic lupus erythematosus. Our observation suggests that ACA and LAC assays should be performed in children with thromboembolic disease even when no underlying autoimmune disease can be found.
Ravelli
A
A
Pediatric Clinic, University of Pavia, Italy.
Caporali
R
R
Bianchi
E
E
Viola
S
S
Solmi
M
M
Montecucco
C
C
Martini
A
A
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology; D001779:Blood Coagulation Factors / Q000276:immunology / Q000302:isolation & purification; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D013577:Syndrome; D013924:Thrombophlebitis / Q000276:immunology*
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor