Report on 604 six-antigen-matched transplants.
1. Two-year 6-antigen-matched graft survival was 82% for first grafts and 72% for second grafts compared to 72% and 60% for the controls. 2. Six-antigen-matched transplants had longer mean ischemia times and recipients had higher levels of antibodies but the effect of these factors was insignificant compared to their effect on the controls. 3. One reason for transplant loss among the 6-antigen-matched recipients was inadequate transplant size. When kidneys from young or old donors were transplanted into heavy recipients, graft survival was 74% compared to 88% for median-age donors. 4. Six-antigen-matched transplants with common phenotypes (greater than 4 cases) had 2-year graft survival of 87% compared to 76% for those which occurred only once. 5. Difficulties in tissue typing certain antigens was shown to have an effect. Six-antigen-matched transplants with antigens defined by at least 80% of the tissue typing laboratories had 89% 1-year graft survival compared to 73% for those with antigens which were more difficult to define. 6. There were fewer homozygous donors and more regraft transplants than expected.
Takemoto
S
S
Carnahan
E
E
Terasaki
P I
PI
D000367:Age Factors; D005500:Follow-Up Studies; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D010641:Phenotype; D012042:Registries; D011795:Surveys and Questionnaires; D014019:Tissue Donors; D014481:United States
D006680:HLA Antigens