The effects of O-(beta-hydroxy-ethyl)-rutosides (HR) on acute lymphoedema in rats' thighs, with and without macrophages.
The effect of O-(beta-hydroxy-ethyl)-rutosides (HR), injected subcutaneously, was investigated on experimental acute lymphoedema in rat thighs. The oedema was reduced from a 30% increase over the normal weight, to one of 13%. When the macrophages were destroyed by the intraperitoneal injection of silica (for eight days before the initiation of lymphoedema) the oedema of the thigh increased to 41% - thus showing the importance of these cells in limiting high-protein oedemas. When HR was given to animals treated with silica the oedema was no longer reduced (42%). Thus HR reduces a high-protein oedema substantially via the macrophages.
Casley-Smith
J R
JR
Henry Thomas Laboratory (Microcirculation Research), Univ. of Adelaide, Australia.
Casley-Smith
J R
JR
D000818:Animals; D006614:Hindlimb; D006896:Hydroxyethylrutoside / Q000627:therapeutic use*; D008209:Lymphedema / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D006896:Hydroxyethylrutoside; D011506:Proteins