[The mechanisms of the decrease in prostatic mass in rats during the administration of estrogenic preparations into the cerebrospinal fluid].
Experiments on albino male rats have shown that the endoliquor administration of estrogens at low doses results in the inhibition of proliferative processes in the prostatic tissues comparable with that observed at the administration of doses two orders larger, and at the subcutaneous administration. A study of the possible mechanism of the observed phenomenon has shown that this effect is associated with the fact that in such a way of estrogen administration conditions are created for deeper inhibition of the production of gonadotropins by the adenohypophysis, and as a result of it a decrease in the androgen level is observed leading to the inhibition of proliferative processes in the prostatic tissues.
Bordiushkov
Iu N
IuN
Kuz'menko
V N
VN
Kirsanova
L D
LD
D000818:Animals; D002555:Cerebrospinal Fluid / Q000187:drug effects*; D003864:Depression, Chemical; D004028:Dienestrol / Q000008:administration & dosage*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007267:Injections; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D010636:Phenols / Q000008:administration & dosage*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D010636:Phenols; D013739:Testosterone; D004054:Diethylstilbestrol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004028:Dienestrol; C000937:diethylstilbestrol dipropionate
Mekhanizmy snizheniia massy predstatel'noĭ zhelezy krys pri éndolikvornom vvedenii éstrogennykh preparatov.