The influence of ethanol on the distribution of amitriptyline and nortriptyline in rats.
The influence of ethanol in single and multiple doses on concentration-time profile of amitriptyline (1) and nortriptyline (2) in rat serum, brain, heart, and liver was studied. AUC0-6 values were calculated and statistically compared as well as cmax values in serum and tissues. Ethanol inhibited N-demethylation of 1 and therefore 2 has not been detected in biological material. AUC0-6 and cmax values were less than in control group. All AUC0-6 and cmax values for 1 in ethanol treated groups of rats were statistically significant compared with the control group.
Negrusz
A
A
Toxicological Department, Medical Academy Cracov, Kraków, Poland.
Brandys
J
J
Piekoszewski
W
W
D000639:Amitriptyline / Q000493:pharmacokinetics*; D000818:Animals; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009661:Nortriptyline / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000639:Amitriptyline; D000431:Ethanol; D009661:Nortriptyline