Praziquantel inhibits Schistosoma mansoni attachment in vitro.
Male adult Schistosoma mansoni worms were placed in a glass dish containing Tyrode solution and observed for 15 min after addition of praziquantel (0.01 to 1 microM). Praziquantel promoted a concentration- and time-dependent inhibition of sucker-mediated attachment of the worm. Attachment inhibition was correlated with shortening of the parasite. We propose that the rapid and total inhibition of worm attachment observed in vitro with 1 microM praziquantel indicates that therapeutic concentrations of this drug should promote a rapid hepatic shift, in vivo, which may facilitate host tissue reaction.
da-Silva
S P
SP
Departamento de Farmacologia Básica e Clínica, Universidade Federal do Rio de Janeiro, Brasil.
Noel
F
F
D000818:Animals; D066298:In Vitro Techniques; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011223:Praziquantel / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects / Q000502:physiology*
D007552:Isotonic Solutions; C037692:Tyrode's solution; D011223:Praziquantel