[Synthesis of N2-aryl-triazinoylamoxicillins and N2-phenyl-N4-alkyl (aryl)-triazinoylamoxicillins and their antibacterial activity].
Sixteen derivatives of BL-P1908 were synthesized by reaction of 2-aryl-1, 2, 4-triazine -3, 5-dione -6-carboxylic acid, or 2-phenyl-4-alkyl (aryl) -1, 2, 4-triazine-3, 5-dione-6-carboxylic acid with amoxicillin. All of them are new compounds. Their chemical structures were determined by elemental analysis, IR and 1HNMR. Preliminary tests showed that all compounds have marked activities against standard G(+) and G(-) bacteria and five of them have certain characteristic of broad spectrum, but they have no activities against resistant strains S. aureus S1, E coli C1 and P. aeruginosa PS1 isolated from clinic.
Zhao
L X
LX
Shenyang College of Pharmacy.
Yao
Q X
QX
D000658:Amoxicillin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D014227:Triazines; D000658:Amoxicillin