Correlation between neopterin, interferon-gamma and haemoglobin in patients with haematological disorders.
In this study, we further investigated a possible link between activation of cell-mediated immunity and anaemia in patients with haematological neoplasias. We compared serum concentrations of interferon-gamma and neopterin with haemoglobin levels. Significantly increased interferon-gamma and neopterin concentrations indicated persistent activation of cell-mediated immunity. Neopterin levels correlated significantly to interferon-gamma concentrations and inversely to haemoglobin levels. The data indicate an association between activated macrophages and the development of anaemia in patients with haematological neoplasias.
Denz
H
H
Department of Internal Medicine, University of Innsbruck, Austria.
Fuchs
D
D
Huber
H
H
Nachbaur
D
D
Reibnegger
G
G
Thaler
J
J
Werner
E R
ER
Wachter
H
H
D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000276:immunology; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006402:Hematologic Diseases / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019798:Neopterin
D006454:Hemoglobins; D001708:Biopterins; D019798:Neopterin; D007371:Interferon-gamma