[Successful treatment of advanced gastric cancer with multiple liver metastasis by combination chemotherapy using mitomycin C, 5-fluorouracil, and high-dose leucovorin: a case report].
A 68-year-old woman complaining of severe iron deficiency anemia was found to have an advanced gastric cancer (poorly differentiated adenocarcinoma) with multiple liver metastases. The patients was treated three times with combination chemotherapy using a monthly schedule consisting of bolus infusion of mitomycin C (10 mg/m2) on day 1, continuous infusion of 5-fluorouracil (600 mg/m2) on day 1 to 6, and continuous infusion of high-dose leucovorin (300 mg/body) on day 1 to 6, with concomitant oral administration of dipyridamole (300 mg/day) over 14 days. Endoscopically, cancerous ulcer in the primary gastric lesion improved like a healed peptic ulcer. Metastatic lesions in the liver almost disappeared on computed tomography. The most prominent side effect was oral mucositis which was tolerable and healed in a week. This regimen appears potentially useful in the treatment of gastric cancer.
Nomura
M
M
First Dept. of Internal Medicine, Faculty of Medicine, Kyushu University.
Nakano
S
S
Kudou
J
J
Ishibashi
O
O
Niho
Y
Y
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D008937:Mitomycins; D016685:Mitomycin; D002955:Leucovorin; D005472:Fluorouracil