Uranyl ion-catalyzed synthesis of several 8-substituted 2'-5'-oligoadenylates, and their properties.
We have synthesized 2'-5' linked oligomers from 8-substituted adenosine-5'-phosphorimidazolides using uranyl ion catalyst. 8-amino derivative, as highly susceptible to hydrolysis, gave short chained oligomers in a low yield, while the rest of 8-substituted or unsubstituted derivatives gave the corresponding oligomers in high yields. Properties of 8-substituted 2'-5' oligomers were studied applying spectrometer and through enzymatic digestion.
Hirano
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Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
Mori
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Sawai
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H
D000227:Adenine Nucleotides / Q000737:chemistry; D000241:Adenosine / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009843:Oligoribonucleotides / Q000737:chemistry; D011108:Polymers; D014501:Uranium / Q000737:chemistry*
D000227:Adenine Nucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D011108:Polymers; D014501:Uranium; C023505:2',5'-oligoadenylate; D000241:Adenosine