Perfluorochemical oxygen carriers and ischaemic tissues.
This paper has outlined the potential beneficial effects of emulsified PFCs for ischaemic tissue rescue. There are very strong indications that PFC emulsions will come to play an important part in the management of the ischaemic tissues. However, the immediate goal of future studies should be to assess the value of improved formulations in this context together with analysis of their mechanism(s) of action, both alone and in combination with other therapeutic agents.
Lowe
K C
KC
Dept. Zoology, University of Nottingham, University Park, UK.
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000628:therapy; D003327:Coronary Disease / Q000628:therapy; D004338:Drug Combinations; D005466:Fluorocarbons / Q000627:therapeutic use; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000628:therapy*
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C008807:perfluorotributylamine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination