Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a seleno-organic compound with glutathione peroxidase-like activity in vitro, was compared with indomethacin, BW 755C, and levamisole as an inhibitor of carrageenan- and CVF (cobra venom factor)-induced paw oedema in the rat. The antiinflammatory potency of ebselen against CVF-induced oedema (ED50 = 56 mg/kg p.o.) was similar to that of BW 755C, while indomethacin was weakly active in this model, and levamisole exerted stronger activity. In the carrageenan model, ebselen exhibited weak inhibitory potency, like BW 755C, while indomethacin markedly inhibited this inflammatory response, and levamisole was inactive. Unlike cyclooxygenase inhibitors, ebselen produced almost no gastric irritation in rats up to 316 mg/kg p.o. Moreover, ebselen inhibited significantly diclofenac-induced gastric intolerance at 31.6 and 316 mg/kg p.o. Thus, ebselen represents a new tool for antiinflammatory therapy.
Leyck
S
S
Rhône-Poulenc/Nattermann, Cologne Research Centre, FRG.
Parnham
M J
MJ
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles / Q000494:pharmacology*; D004008:Diclofenac / Q000037:antagonists & inhibitors; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004546:Elapid Venoms / Q000037:antagonists & inhibitors; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D054833:Isoindoles; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D016566:Organoselenium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D004546:Elapid Venoms; D054833:Isoindoles; D016566:Organoselenium Compounds; C016310:cobra venom factor; D004008:Diclofenac; D007978:Levamisole; C042986:ebselen; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D012643:Selenium; D007213:Indomethacin