Effects of aluminum on erythroidal cells in bone marrow in rats.
The study has been carried out on Wistar rats. The aim of the present study was to trace the effect of aluminum on erythroidal cells in bone marrow in rats. The number of proerythroblast after 10 days of experiment with aluminum slowly decreased up to 80 days of experiments. However, the number of basophilic erythroblasts after 10 days insignificantly increased but after 20 days gradually decreased up to 80 days of experiments. The bone marrow polichromatic erythroblasts after 10 days of experiment slightly decreased, however after 20, 40 and 80 days of experiments the values decreased significantly. The quality of orthochromatic erythroblasts after 10 days of experiments dropped and after 20, 40 and 80 days of experiments significantly decreased compared to the control value. Aluminum also brings about histological changes in the bone marrow. The statistical significant reductions of hemoglobin and hematocrit levels were found in the aluminum exposed rats.
Zaman
K
K
Laboratory of Experimental Haematology and Toxicology, Jagellonian University, Kraków, Poland.
Dabrowski
Z
Z
Miszta
H
H
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001491:Basophils / Q000166:cytology / Q000187:drug effects; D001854:Bone Marrow Cells; D004900:Erythroblasts / Q000166:cytology* / Q000187:drug effects; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D006454:Hemoglobins; D000535:Aluminum