title: Maternal and fetal catecholamines and uterine incision-to-delivery interval during elective cesarean.
abstract: The fetal sympathoadrenal system is activated during periods of intrauterine stress such as inadequate uterine perfusion. During cesarean, the period of interruption of utero-placental blood flow is extended as the time interval from uterine incision to delivery increases. An increasing uterine incision-to-delivery interval with spinal or general anesthesia has been associated with a poorer neonatal outcome. This association has not been demonstrated previously in patients undergoing cesarean delivery under epidural anesthesia. We investigated the correlation between prolonged uterine incision-to-delivery intervals, fetal catecholamine concentrations, and fetal blood gas values at delivery in 25 parturients undergoing cesarean under epidural anesthesia and in 28 under spinal anesthesia. Infants delivered after prolonged uterine incision-to-delivery intervals had significantly lower pH values in both the epidural and spinal groups. With longer uterine incision-to-delivery intervals, umbilical arterial norepinephrine concentrations were increased significantly. Umbilical arterial pH values were significantly lower in infants with higher umbilical arterial catecholamine concentrations. The importance of minimizing the uterine incision-to-delivery interval, regardless of the type of anesthetic selected, is demonstrated.
authors.affiliation: Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: A M
authors.initials: AM
authors.lastname: Bader
authors.forename: S
authors.initials: S
authors.lastname: Datta
authors.forename: G R
authors.initials: GR
authors.lastname: Arthur
authors.forename: E
authors.initials: E
authors.lastname: Benvenuti
authors.forename: M
authors.initials: M
authors.lastname: Courtney
authors.forename: M
authors.initials: M
authors.lastname: Hauch
mesh_terms: D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002245:Carbon Dioxide / Q000097:blood; D002585:Cesarean Section; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009638:Norepinephrine / Q000097:blood*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen; D009638:Norepinephrine; D004837:Epinephrine