title: [Pharmacokinetic methods for achieving and maintaining stationary plasma levels in the venous administration of drugs].
abstract: Proceeding from extensive review of the available literature, the authors discuss the possibilities which pharmacokinetic modelling offers for achieving precise dosage of intravenously administered drugs. Problems associated with the development of pharmacokinetic models depending on the distributive characteristics of the drugs in the body and the desired plasma concentration are principally discussed. Concrete examples for attaining and maintaining stationary plasma concentrations of some intravenously administered drugs in anesthesiologic practice and intensive treatment are indicated.
authors.forename: I
authors.initials: I
authors.lastname: Iamboliev
authors.forename: D
authors.initials: D
authors.lastname: Genov
mesh_terms: D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods*; D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations
vernacular_title: Farmakokinetichni metodi za dostigane i poddŭrzhane na statsionarni plazmeni niva pri venozno vŭvezhdane na medikamentite.