title: Mixed acenannellated metallotetraazaporphins: a new class of amphiphilic photosensitizers for the photodynamic therapy of cancer.
abstract: The first synthesis of amphiphilic mixed acenannellated metallotetraazaporphins compounds, designed with the aim of improving cell membrane penetration, is described and the preliminary results on their photocytotoxicity are presented.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France.
authors.forename: S
authors.initials: S
authors.lastname: Gaspard
authors.forename: P
authors.initials: P
authors.lastname: Margaron
authors.forename: C
authors.initials: C
authors.lastname: Tempête
authors.forename: T H
authors.initials: TH
authors.lastname: Thi
mesh_terms: D001372:Aza Compounds / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008027:Light; D008665:Metalloporphyrins / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy*; D010777:Photochemistry; D010778:Photochemotherapy / Q000379:methods*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects
chemical_list: D001372:Aza Compounds; D008665:Metalloporphyrins; D011838:Radiation-Sensitizing Agents