title: [Results of treatment of Hodgkin's disease in children. Observation of 203 cases treated with modified MVPP regimen combined with local radiotherapy].
abstract: Totally 209 children were treated within 1971-1982. Complete remission was achieved in 95.6%. Recurrence was noted in 36 patients (18.6%); 20 patients (9.9%) died due to progression of the disease and 9 patients (4.4%) because of complications. The first remission remains constantly in 150 patients for 63-206 months, including that after completion of therapy during 45-206 months. Asymptomatic 5- and 10-year survivals are the following: 82.9% and 80.1% respectively; 5- and 10-year survivals 91.9% and 89.8%, respectively. Expanded experience served as base to design a new regimen (introduced in 1988) which is being supposed to reduce untoward reaction by decreasing the number of MVPP cycles and irradiation doses.
authors.affiliation: Kliniki Hematologii Dzieciecej IP AM w Krakowie.
authors.forename: W
authors.initials: W
authors.lastname: Balwierz
authors.forename: J
authors.initials: J
authors.lastname: Armata
authors.forename: A
authors.initials: A
authors.lastname: Moryl-Bujakowska
authors.forename: T
authors.initials: T
authors.lastname: Depowska
authors.forename: U
authors.initials: U
authors.lastname: Radwańska
authors.forename: M
authors.initials: M
authors.lastname: Kaczmarek
authors.forename: M
authors.initials: M
authors.lastname: Ochocka
authors.forename: E
authors.initials: E
authors.lastname: Stańczak
authors.forename: D
authors.initials: D
authors.lastname: Sońta-Jakimczyk
authors.forename: M
authors.initials: M
authors.lastname: Sroczyńska
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D012008:Recurrence; D012074:Remission Induction; D015996:Survival Rate; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D008466:Mechlorethamine; D014747:Vinblastine; D011239:Prednisolone
vernacular_title: Wyniki leczenia choroby Hodgkina u dzieci. Obserwacja 203 przypadków leczonych zmodyfikowana chemioterapia MVPP skojarzona z miejscowym napromienianiem.