Noradrenaline turnover in the tissues of uraemic rats.
In female Wistar rats with acute renal failure a decrease of noradrenaline concentration in the heart, spleen and kidney was ascertained. Noradrenaline concentration after alpha-methyl-p-tyrosine and 6-hydroxydopamine in the heart, spleen and kidney was significantly lower than in the control group. In the adrenals a decrease of catecholamine level after alpha-methyl-p-tyrosine and 6-hydroxydopamine has been noted in the controls. The changes in tissue noradrenaline concentration are evidence of a dysfunction in the adrenergic nervous system in uraemic rats.
Ksiazek
A
A
Department of Nephrology, Medical School, Lublin, Poland.
Solski
J
J
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008781:Methyltyrosines / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism; D014511:Uremia / Q000378:metabolism*; D019805:alpha-Methyltyrosine
D002395:Catecholamines; D006892:Hydroxydopamines; D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D016627:Oxidopamine; D009638:Norepinephrine