Childhood brain tumor: presentation at younger age is associated with a family tumor history.
In a registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p = 0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.
Sussman
A
A
Harvard Medical School, Boston.
Leviton
A
A
Allred
E N
EN
Aschenbrener
C
C
Austin
D F
DF
Gilles
F H
FH
Hedley-Whyte
E T
ET
Kolonel
L N
LN
Lyon
J L
JL
Swanson
G M
GM
D000367:Age Factors; D001932:Brain Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008527:Medulloblastoma / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D012042:Registries