title: [Specific hyposensitization of microbial allergy by using a synthetic artificial polyelectrolyte].
abstract: In this work the effectiveness of complex immunotherapy, including specific inhalation hyposensitization with the introduction of artificial synthetic polyelectrolite, was studied. Specific allergen produced a good effect (75%) in the inhalation hyposensitization of hemophilic allergy. The intramuscular injection of artificial synthetic polyelectrolite, made in addition to the inhalation of allergen, produced a better desensitizing effect than the separate administration of allergen or polyelectrolite. The multiple administration of polyelectrolite produced a desensitizing effect on allergic reactions of type I with the tendency towards the decrease of reactions of type IV. Good prospects for the development of methods for special treatment with homologous allergen in combination with NA-5 in cases of microbial sensitization under the control of immunocompetent cells were shown.
authors.forename: V P
authors.initials: VP
authors.lastname: Dobritsa
authors.forename: G S
authors.initials: GS
authors.lastname: Sukhodoeva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lisitsyn
authors.forename: E N
authors.initials: EN
authors.lastname: Ospanova
mesh_terms: D000179:Acrylates / Q000627:therapeutic use*; D000180:Acrylic Resins / Q000627:therapeutic use*; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000280:Administration, Inhalation; D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D003888:Desensitization, Immunologic / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006192:Haemophilus Infections / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D006193:Haemophilus influenzae / Q000276:immunology; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D007273:Injections, Intramuscular; D008297:Male; D011205:Povidone / Q000627:therapeutic use* / Q000031:analogs & derivatives; D011760:Pyrrolidinones / Q000627:therapeutic use*
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D000276:Adjuvants, Immunologic; D000485:Allergens; D011760:Pyrrolidinones; C043348:acrylic acid-N-vinylpyrrolidone copolymer; C042670:N-vinyl-2-pyrrolidinone; D011205:Povidone; C036658:acrylic acid
vernacular_title: Spetsificheskaia giposensibilizatsiia mikrobnoĭ allergii s ispol'zovaniem sinteticheskogo neprirodnogo poliélektrolita.