title: Genetic restriction of protective immunity to Plasmodium yoelii sporozoites.
abstract: Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8+ T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.
authors.affiliation: Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814.
authors.forename: W R
authors.initials: WR
authors.lastname: Weiss
authors.forename: M F
authors.initials: MF
authors.lastname: Good
authors.forename: M R
authors.initials: MR
authors.lastname: Hollingdale
authors.forename: L H
authors.initials: LH
authors.lastname: Miller
authors.forename: J A
authors.initials: JA
authors.lastname: Berzofsky
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D007116:Immunization, Passive; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D010967:Plasmodium yoelii / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan