Alterations of intestinal permeability to sugars in infants following neonatal surgery.
The 12-h urinary elimination of orally ingested mannitol and lactulose was studied in 29 infants aged 3 days-20 months admitted in an intensive care unit of gastrointestinal surgery, and in 24 age-matched healthy controls. In patients with short bowel syndrome, there was a significant fourfold reduction in urinary mannitol elimination compared with controls. The lactulose/mannitol urinary ratio was significantly increased in patients with necrotizing enterocolitis (p less than 0.01) and in patients with disorders of intestinal propulsion during episodes of diarrhea with a monomorphic fecal flora (p less than 0.01). The urinary recovery of mannitol and lactulose after oral loads is a good marker of intestinal mucosal damage in infants with surgical disorders of the digestive tract.
Dupont
C
C
Department of Pediatrics, Hôpital Saint Vincent de Paul, Paris, France.
Goutail-Flaud
M F
MF
D004040:Dietary Carbohydrates / Q000378:metabolism; D004187:Disaccharides / Q000378:metabolism*; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007408:Intestinal Absorption / Q000502:physiology; D007792:Lactulose / Q000378:metabolism* / Q000652:urine; D008286:Malabsorption Syndromes / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism* / Q000652:urine; D011183:Postoperative Complications / Q000378:metabolism*
D004040:Dietary Carbohydrates; D004187:Disaccharides; D008353:Mannitol; D007792:Lactulose