title: Effect of home total parenteral nutrition on body composition in patients with acquired immunodeficiency syndrome.
abstract: Malnutrition occurs commonly in patients with acquired immunodeficiency syndrome (AIDS). The efficacy of nutritional support is unknown. A prospective, longitudinal study was conducted to determine the effect of prolonged total parenteral nutrition on body composition in 12 AIDS patients. Five patients were malnourished because of problems with food intake or absorption, while seven had systemic infections, with or without a malabsorption syndrome. The AIDS patients gained body weight and body fat content in response to total parenteral nutrition, while mean body cell mass, estimated as total body potassium content, was unchanged. However, all five patients with altered intake or absorption had significant repletion of body cell mass which was significantly different from the patients with systemic infections. Calorie and nitrogen intake did not differ between the two groups. It is concluded that body mass repletion is possible in AIDS patients in whom malabsorption is the major pathogenetic factor in producing malnutrition and is less successful in patients with serious ongoing systemic diseases. Thus, the response to nutritional support is dependent on the particular clinical circumstances.
authors.affiliation: Gastrointestinal Division, St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10025.
authors.forename: D P
authors.initials: DP
authors.lastname: Kotler
authors.forename: A R
authors.initials: AR
authors.lastname: Tierney
authors.forename: J A
authors.initials: JA
authors.lastname: Culpepper-Morgan
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: R N
authors.initials: RN
authors.lastname: Pierson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000628:therapy*; D000328:Adult; D001823:Body Composition / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D006701:Home Nursing; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009748:Nutrition Disorders / Q000150:complications / Q000628:therapy*; D010289:Parenteral Nutrition, Total / Q000379:methods; D011446:Prospective Studies
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins