Correlation of photically evoked afterdischarge parameters to the respiration rate and their modulation by basal forebrain and nucleus cuneiformis stimulation in the freely moving rat.
On 29 freely moving Long-Evans rats the correlations of various parameters of photically evoked afterdischarges (PhAD) with respiration rate were observed and statistically evaluated. Increasing respiration rate is related with PhAD of reduced amplitude, higher number per flash and increased frequency. PhAD show their best appearance at frequencies around 6.2 PhAD/s. At frequencies below 5.9 and above 6.4/s PhAD number and amplitude decreased. Electrical single impulse stimulation of the nucleus cuneiformis (Cnf) decreased PhAD trigger rate significantly stronger than basal forebrain (Bf) stimulation from 10 rats. The Cnf stimulation effects on PhAD continued longer than Bf stimulation effects which is also recognizable on the different modulations of the PhAD amplitude and frequency. After the desynchronizing stimulation effects, more synchronized PhAD were found, which indicates a desynchronization-synchronization sequence of the PhAD modulation after Bf and Cnf stimulation.
Bringmann
A
A
Institute for Neurobiology and Brain Research, Academy of Sciences, Magdeburg.
Klingberg
F
F
D000818:Animals; D001921:Brain / Q000502:physiology*; D004558:Electric Stimulation; D005074:Evoked Potentials, Visual; D005260:Female; D008636:Mesencephalon / Q000502:physiology*; D009068:Movement; D051381:Rats; D012119:Respiration; D014851:Wakefulness