The response of advanced prostatic cancer to a new non-steroidal antiandrogen: results of a multicenter open phase II study of Casodex. European/Australian Co-operative Group.
Casodex is a non-steroidal antiandrogen which shows marked peripheral selectivity in animals. As an antiandrogen, it has been shown in a dose ranging and an open phase II study to have fewer side-effects than traditional non-steroidal antiandrogens and to be very well tolerated. In the open phase II study, the 50 mg dose was used in 127 evaluable patients who have been treated for up to 1 year. Overall response (i.e. partial response [PR]) was 50% with a further 33% showing stabilization of disease.
Newling
D W
DW
Department of Urology, Free University of Amsterdam, The Netherlands.
D000368:Aged; D000369:Aged, 80 and over; D000813:Anilides / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D001940:Breast / Q000187:drug effects; D004244:Dizziness / Q000139:chemically induced; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009570:Nitriles; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014105:Tosyl Compounds
D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide