title: Listericidal activity of human neutrophil cathepsin G.
abstract: We demonstrate that cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule. The listericidal activity of cathepsin G occurred in a manner that was both time-dependent and concentration-dependent.
authors.affiliation: Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
authors.forename: C E
authors.initials: CE
authors.lastname: Alford
authors.forename: E
authors.initials: E
authors.lastname: Amaral
authors.forename: P A
authors.initials: PA
authors.lastname: Campbell
mesh_terms: D056649:Cathepsin G; D002403:Cathepsins / Q000494:pharmacology*; D002412:Cations; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008089:Listeria monocytogenes / Q000187:drug effects*; D009504:Neutrophils / Q000201:enzymology*; D012697:Serine Endopeptidases
chemical_list: D002412:Cations; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G