Biodegradable lysine diisocyanate-based poly(glycolide-co-epsilon-caprolactone)-urethane network in artificial skin.
A biodegradable lysine diisocyanate-based poly(glycolide-co-epsilon-caprolactone)urethane network has been evaluated as a material for the construction of a macroporous bottom layer (dermal analogue) in a two-layer artificial skin. High rates of in vitro degradation were observed; degradation of the porous poly(glycolide-co-epsilon-caprolactone)urethane networks was faster in vivo than in vitro. Subcutaneous implantation in guinea pigs showed that the porous polyurethane networks allowed rapid cell ingrowth, degraded almost completely 4-8 wk after implantation and evoked no adverse tissue reaction.
Bruin
P
P
Department of Polymer Chemistry, University of Groningen, The Netherlands.
Smedinga
J
J
Pennings
A J
AJ
Jonkman
M F
MF
D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001673:Biodegradation, Environmental; D003485:Cyanates; D006168:Guinea Pigs; D008239:Lysine / Q000031:analogs & derivatives; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000138:chemical synthesis; D019736:Prostheses and Implants; D012867:Skin
D001672:Biocompatible Materials; D003485:Cyanates; D011091:Polyesters; C062968:lactide-caprolactone copolymer; D008239:Lysine