Antibacterial activity of fluoroquinolones in combination with zidovudine.
Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or Pseudomonas aeruginosa. Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.
Lewin
C S
CS
Department of Bacteriology, University of Edinburgh Medical School.
Allen
R A
RA
Amyes
S G
SG
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D015365:Enoxacin / Q000008:administration & dosage*; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000008:administration & dosage*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D015363:Quinolones; D012475:Salmonella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D015215:Zidovudine / Q000008:administration & dosage*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015365:Enoxacin; D015215:Zidovudine; D002939:Ciprofloxacin; D015242:Ofloxacin; C053091:lomefloxacin