Removal of immunosuppressive substance in cancer patients' serum.
Anemia-inducing substance (AIS) appears in plasma as cancer progresses. In this study, a non-coated charcoal column was used to remove AIS from the cachectic plasma obtained from patients with advanced cancer. AIS could be completely removed by 6 cycles of adsorption using this column. Similar data were obtained in an experiment using VX-2-transplanted rabbits. These observations raised the possibility that plasmapheresis with a non-coated charcoal column may be available as a new means of immunotherapy for advanced cancer.
Ishiko
O
O
Department of Obstetrics and Gynecology, Osaka City University Medical School.
Deguchi
M
M
Tatsuta
I
I
Naka
K
K
Hirai
K
K
Nakata
S
S
Honda
K
K
Sugawa
T
T
D001685:Biological Factors / Q000302:isolation & purification*; D001798:Blood Proteins / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000628:therapy; D002606:Charcoal; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007167:Immunotherapy; D010051:Ovarian Neoplasms / Q000150:complications / Q000276:immunology* / Q000628:therapy; D010956:Plasmapheresis
D001685:Biological Factors; D001798:Blood Proteins; D002606:Charcoal