Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds.
The effects of first and second generation hypoglycemic sulfonylureas on the incidence of ventricular ectopic beats and on the duration of transitional ventricular fibrillation in the ischemic rat heart were investigated. First generation sulfonylurea compounds (tolbutamide, carbutamide and gliclazide) in 105 preparations increased, while second generation sulfonylurea compounds (glibenclamide and glipizide) in 50 preparations decreased in a dose-dependent manner both the number of ventricular ectopic beats and the duration of transitional ventricular fibrillation during the first 30 min after ligation of the left anterior descending coronary artery. Therefore, second generation sulfonylureas should be preferred in the treatment of type 2 diabetics with ischemic heart diseases, if satisfactory metabolic control cannot be achieved by a treatment regimen and diet alone.
Ballagi-Pordány
G
G
National Institute of Cardiology, Research Department, Budapest, Hungary.
Köszeghy
A
A
Koltai
M Z
MZ
Aranyi
Z
Z
Pogátsa
G
G
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D002271:Carbutamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D005907:Gliclazide / Q000494:pharmacology; D005913:Glipizide / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013329:Structure-Activity Relationship; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D014044:Tolbutamide; D002271:Carbutamide; D005907:Gliclazide; D011188:Potassium; D005905:Glyburide; D005913:Glipizide