Postnatal development of the glycine cleavage system in rat liver.
The development of the glycine cleavage system was studied in liver mitochondrial extracts from neonatal and adult rats. The enzyme activity in 2-day-old pups was 29.3% of that measured in the adult and was found to increase in an age-dependent manner. Measurement of hepatic free amino acid concentrations at the neonatal ages showed that glycine levels were highest at 2 days and at 14 days were about 48% of those in the 2-day-old pups. Serine levels did not change between the age of 2 and 14 days. A developmental delay in the glycine cleavage system is responsible for the high levels of glycine in the neonatal rat liver.
Kalbag
S S
SS
Nassau County Medical Center, Department of Pediatrics, State University of New York, East Meadow 11554.
Palekar
A G
AG
D000375:Aging / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D050960:Aminomethyltransferase; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005260:Female; D005998:Glycine / Q000378:metabolism*; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D019877:Hydroxymethyl and Formyl Transferases; D008099:Liver / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*
D000596:Amino Acids; D012694:Serine; D014166:Transferases; D019877:Hydroxymethyl and Formyl Transferases; D012696:Glycine Hydroxymethyltransferase; D050960:Aminomethyltransferase; D005998:Glycine