Proteolysis in neuropeptide processing.
The paper reviews the functions of proteolytic enzymes in processing intracellular peptides. The enzymes may "activate" precursors of active peptides, "inactivate" active peptides by their degradation to biologically inactive forms, and "change" the peptides degrading biologically active forms to smaller peptides of different biological activity. The results of own studies on angiotensin II and its fragments are quoted to illustrate how various fragments of the peptide may display various biological activity.
Wiśniewski
K
K
Department of Pharmacology, Chair of Pharmacology, Medical Academy, Bialýstok, Poland.
Braszko
J
J
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D009479:Neuropeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000502:physiology*; D051381:Rats
D009479:Neuropeptides; D010446:Peptide Fragments; D000804:Angiotensin II; D010447:Peptide Hydrolases