title: [Immunoglobulin therapy of postoperative sepsis].
abstract: 35 patients with septic postoperative complications entered a prospectively randomized study. The clinical state of these patients was daily determined using the sepsis score described by Elebute and Stoner. Endotoxin and antithrombin III were measured in the plasma using the limulus-amoebocyte-lysat test for endotoxin determination. The septic patients were treated with an immunoglobulin preparation (Pentaglobin) administered by the intravenous route. This preparation is enriched in IgM and IgA. Due to the immunoglobulin therapy the endotoxin titres decreased; simultaneously a reduction of mortality and shortening of time of hospitalization and of mechanical ventilation were observed.
authors.affiliation: Chirurgische Universitätsklinik Köln-Lindenthal.
authors.forename: C
authors.initials: C
authors.lastname: Wesoly
authors.forename: N
authors.initials: N
authors.lastname: Kipping
authors.forename: R
authors.initials: R
authors.lastname: Grundmann
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D004731:Endotoxins / Q000032:analysis; D006801:Humans; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000627:therapeutic use; D007136:Immunoglobulins / Q000008:administration & dosage; D011183:Postoperative Complications / Q000628:therapy*; D011446:Prospective Studies; D018805:Sepsis / Q000628:therapy*
chemical_list: D004731:Endotoxins; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007136:Immunoglobulins; D000990:Antithrombin III
vernacular_title: Immunglobulintherapie der postoperativen Sepsis.