Renal and hemodynamic effects of dopamine in infants following cardiac surgery.
The renal and hemodynamic effects of dopamine were measured during the immediate postoperative period in six infants following repair of congenital cardiac defects. Dopamine was infused at rates of 5, 10, and 15 micrograms/kg/min. Cardiac index (CI) increased significantly at a dopamine infusion rate of 15 micrograms/kg/min. The glomerular filtration rate (GFR) and urine output increased at dopamine infusion rates of 5 and 10 micrograms/kg/min and returned to baseline at 15 micrograms/kg/min. No significant changes occurred in right atrial pressure (RAP), left atrial pressure (LAP), systemic artery pressure, systemic vascular resistance (SVR), or pulmonary vascular resistance (PVR). Heart rate (HR) increased slightly at a dopamine infusion rate of 15 micrograms/kg/min. Pulmonary artery pressure (PAP) increased significantly in only one patient. These data demonstrate that infants require high doses of dopamine to produce the hemodynamic effects seen in adults and that these higher doses may be used without adverse renal effects.
Outwater
K M
KM
Department of Pediatrics, Children's Hospital, Boston, MA.
Treves
S T
ST
Lang
P
P
Castaneda
A R
AR
Crone
R K
RK
D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006330:Heart Defects, Congenital / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects*; D015609:Organotechnetium Compounds; D010100:Oxygen / Q000097:blood; D004369:Pentetic Acid; D011651:Pulmonary Artery / Q000502:physiology; D016284:Technetium Tc 99m Pentetate; D014556:Urine / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects
D015609:Organotechnetium Compounds; D002245:Carbon Dioxide; D004369:Pentetic Acid; D010100:Oxygen; D004298:Dopamine; D016284:Technetium Tc 99m Pentetate