Major histocompatibility complex regulation of the class of the immune response: the H-2d haplotype determines poor interferon-gamma response to several antigens.
The lymph node cells of CBA (H-2k), but not BALB/c (H-2d) mice, release interferon (IFN)-gamma into the supernatant when immunized with picryl chloride epicutaneously and then exposed to antigen (haptenized cells) in vitro 4 days later. The failure in IFN-gamma production maps to the major histocompatibility complex (MHC; H-2d) in the congenic BALB/c, BALB/k and BALB/b mice. The evidence that this is an MHC regulation of the class of response to a range of antigens and not a classical Ir gene effect is (a) the difference is seen with several antigens including picryl chloride, "oxazolone" and purified protein derivative of tuberculin and (b) BALB/c mice, which fail to produce IFN-gamma, show excellent contact sensitivity to picryl chloride. It was also found that the crosses between responder and nonresponder strains (CBA x BALB/c)F1 respond to antigen on responder cell but not on nonresponder cells. This influence of MHC on the class of the immune response is a possible basis for some of the associations of MHC with disease.
Asherson
G L
GL
Division of Immunological Medicine, Clinical Research Centre, Harrow, GB.
Dieli
F
F
Gautam
Y
Y
Siew
L K
LK
Zembala
M
M
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D064532:Histocompatibility Antigen H-2D; D007109:Immunity / Q000235:genetics*; D007371:Interferon-gamma / Q000096:biosynthesis*; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains
D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D007371:Interferon-gamma