[Pancreatic passenger leukocytes in organs obtained from cadaver donors for allotransplantation].
In previous studies we have demonstrated that human normal pancreata were populated by interstitial mononuclear cells constituted by dendritic cells (70%), macrophages (30%) and few B cells (less than 1%). Furthermore, the endocrine parenchyma and the centroacinar cells appeared negative for the detection of HLA-A,B,C molecules. In the present report, 15 pancreata from cadaver donors were studied by means of immunohistochemical methods. 5 out of 15 organs were found to contain a larger amount of interstitial hematic cells that were constituted mainly by macrophages and B cells, together with a small percentage of granulocytes and T cells. In such "infiltrated" pancreata both endocrine parenchyma and centroacinar cells displayed a positivity for HLA-A,B,C antigens. As HLA-class I antigens have importance in allo-recognition and rejection responses, our data suggest that pre-transplant biopsies may be useful for a better evaluation of the pancreatic tissue immunogenicity.
Leprini
A
A
Istituto di Anatomia Umana, Università degli studi di Genova.
Valente
U
U
Barocci
S
S
Fontana
I
I
Leprini
A E
AE
Bottero
S
S
Nocera
A
A
D002102:Cadaver; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D016035:Pancreas Transplantation / Q000276:immunology* / Q000473:pathology; D014019:Tissue Donors; D014181:Transplantation Immunology / Q000276:immunology*
D006680:HLA Antigens
I "passenger leukocytes" pancreatici in organi prelevati da donatore cadavere per allotrapianto.