Effect of selective monoamine oxidase A and B inhibitors on footshock induced aggression in paired rats.
Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats. The doses and pretreatment times of the inhibitors used were based on an earlier reported in vivo dose-response and time-course study. In addition, apomorphine, a dopaminergic receptor agonist, and beta-phenylethylamine, a preferred substrate for MAO-B, were also used to garner corroborative evidence. The results of the study indicate that selective MAO-A inhibitors are likely to attenuate FIA by augmenting central serotonergic activity, while selective MAO-B inhibitors accentuate the behaviour by facilitating dopaminergic activity. A permissive role for noradrenaline could not be delineated by the available data.
Datla
K P
KP
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Bhattacharya
S K
SK
D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003010:Clorgyline / Q000494:pharmacology*; D005260:Female; D008297:Male; D008995:Monoamine Oxidase / Q000145:classification / Q000502:physiology; D009526:Nialamide / Q000494:pharmacology*; D010146:Pain; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology*
D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline; D001058:Apomorphine; D009526:Nialamide