title: Total hemolytic complement (CH50) and its fractions (C3 and C4) in the sera of diabetic patients with periodontitis.
abstract: The total hemolytic complement activity (CH50) and its fractions C3 and C4 were determined in 50 patients with Type II or non-insulin dependent diabetes mellitus (NIDDM) and 50 nondiabetic patients with periodontitis. The values were compared with those of 50 age and sex matched controls. An elevation of CH50 was observed in both the diabetic and nondiabetic patients, compared to controls. The diabetic patients with periodontitis showed a significantly higher complement activity compared to nondiabetic patients with periodontitis. The C3 and C4 values were significantly elevated in both diabetic and nondiabetic patients when compared with the control group. The elevation being more pronounced in diabetic groups.
authors.affiliation: Department of Periodontics Dental College, Trivandrum, Kerala, South India.
authors.forename: S
authors.initials: S
authors.lastname: Anil
authors.forename: P
authors.initials: P
authors.lastname: Remani
authors.forename: T
authors.initials: T
authors.lastname: Vijayakumar
authors.forename: P A
authors.initials: PA
authors.lastname: Joseph
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D015941:Complement Hemolytic Activity Assay; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D010518:Periodontitis / Q000097:blood* / Q000276:immunology
chemical_list: D003176:Complement C3; D003181:Complement C4