[Incidence of pathologic ammonia concentrations in the plasma in children with seizure disorders treated with Convulsofin/Convulex and other anticonvulsants in comparison with children with brain damage and healthy children].
In healthy children plasma ammonia concentrations show values from 12.3 to 57.2 mumol/l (80%-range) (group I). We also measured plasma ammonia in epilepsy patients with valproate therapy (group II) and epilepsy patients treated with other anticonvulsiva (group III). In a fourth group there were children with various cerebral lesions without episodes and without anticonvulsiva therapy. There were significant differences between group I and group II and group II and group IV respectively. But no significant differences were found between the patients who were treated with valproate and the patients with cerebral lesions. The data does not allow the plasma ammonia concentration to be taken as a control parameter in children treated with valproate. Ammonia estimation at the beginning of therapy, however, may be used as risk indicator.
Wiedemann
G
G
Klinik und Poliklinik für Kindermedizin, Medizinischen Akademie Erfurt.
Haupt
M
M
Rommel
A
A
Rommel
K F
KF
Biesenbach
R
R
Schmidt
W
W
D000293:Adolescent; D000641:Ammonia / Q000097:blood*; D000927:Anticonvulsants / Q000009:adverse effects*; D001925:Brain Damage, Chronic / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid; D000641:Ammonia
Untersuchungen zur Häufigkeit pathologischer Ammoniakkonzentrationen im Plasma bei Kindern mit Anfallsleiden unter der Behandlung mit Convulsofin/Convulex und anderer Antikonvulsiva im Vergleich zu Kindern mit Zerebralschäden und gesunden Kindern.