The role of phospholipase A2 in lipid peroxidation-induced fall of membrane potential of rat liver mitochondria.
Cumene hydroperoxide (230 microM)-induced fall of the membrane potential takes place only in Ca2(+)-loaded mitochondria. Inhibitor of phospholipase A2 p-bromphenacyl bromide prevents uncoupling of mitochondria, having no effect on the accumulation of lipid peroxidation products.
Gogvadze
V G
VG
Institute of Biological Physics, USSR Academy of Sciences, Pushchino.
Brustovetsky
N N
NN
Zhukova
A A
AA
D000098:Acetophenones / Q000494:pharmacology; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D004533:Egtazic Acid / Q000494:pharmacology; D015227:Lipid Peroxidation; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000201:enzymology*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats
D000098:Acetophenones; D001555:Benzene Derivatives; D004533:Egtazic Acid; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; C007164:cumene hydroperoxide; C006821:4-bromophenacyl bromide; D002118:Calcium