Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.
Drivas
G T
GT
Department of Biochemistry, New York University School of Medicine, New York 10016.
Shih
A
A
Coutavas
E
E
Rush
M G
MG
D'Eustachio
P
P
D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D019204:GTP-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D015723:Gene Library; D011905:Genes, ras; D006801:Humans; D007256:Information Systems; D008969:Molecular Sequence Data; D005810:Multigene Family; D015345:Oligonucleotide Probes; D012689:Sequence Homology, Nucleic Acid; D013724:Teratoma / Q000235:genetics*
D015345:Oligonucleotide Probes; D019204:GTP-Binding Proteins