title: [Effectiveness and tolerance of long-term uricosuric treatment].
abstract: In an open-controlled, randomized trial over 24 weeks, the serum uric acid lowering effect of a daily dose of 100 mg allopurinol in combination with 20 mg benzbromarone compared to 300 mg allopurinol only was investigated on a total of 60 patients suffering from hyperuricemia. Both preparations led to a decrease of the serum uric acid value to normal. In those patients however, who had received the combination the reduction of the serum uric acid level was more pronounced. Tolerance was generally good. Side-effects were not reported.
authors.forename: H
authors.initials: H
authors.lastname: Berg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000008:administration & dosage* / Q000009:adverse effects; D001553:Benzbromarone / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006073:Gout / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007669:Kidney Calculi / Q000097:blood / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D004338:Drug Combinations; D014527:Uric Acid; D001553:Benzbromarone; D000493:Allopurinol
vernacular_title: Untersuchungen zur Wirksamkeit und Verträglichkeit einer längerfristigen harnsäuresenkenden Behandlung.