[Enhancement of mononuclear leukocyte-mediated anti-tumoral activity by cells of the B cell-line].
Cytotoxic activity of human mononuclear leukocytes (MNLs) against various tumor cell-line cells was induced by irradiated B cell-line cells. Each B cell-line cell was found to have a different potentiality and time kinetics on the induction of cytotoxicity. The enhancing effect of some B cell-line cells was found to be related to the IL-2 production from the MNLs, but not related to the IFN, TNF, and LT production. An analysis of the effector cells of the B cell-activating-killer cells (BAK) indicated that the population of the major effector cells were monocytes and NK cells. These results have provided evidence that B cell-line cells are capable of enhancing nonspecific cytotoxic activity of the MNLs, and that they might be new biological response modifiers of cancer immunotherapy.
Takamura
S
S
Dept. of Neurosurgery, Kumamoto Univ. Med. School.
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001402:B-Lymphocytes / Q000502:physiology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005910:Glioma / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D009000:Monocytes / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
D000911:Antibodies, Monoclonal; D007376:Interleukin-2; D007371:Interferon-gamma