Persistent Schistosoma mansoni infection in Yemeni immigrants to Israel.
Following sporadic reports on persistent Schistosoma mansoni (S.m) infections in Israelis of Yemeni origin, we systematically surveyed a group of 129 individuals who immigrated to Israel 38 years ago. Physical examination was uneventful in all members of the study group. A single stool examination revealed S.m eggs in 15 of 129 subjects (12%). Specific anti-S.m. IgE was detected in the sera of 48 individuals (37%). Among the 15 egg-positives, 14 had specific IgE (sensitivity 93.3%), but only 80 of the 114 egg-negatives were also negative for specific IgE (specificity 70%). This specific IgE positivity among egg-negatives in the study group (34/114) and its complete absence from two control groups, one of them comprising Yemenites born in Israel, suggest either an S.m infection with low egg output stemming from a low worm burden or low fecundity of senescent worms, or occult infections. Since the S.m infections could not have been contracted in Israel, our findings point to inordinately persistent infections in the members of our study group, and incidentally also to the diagnostic usefulness of specific IgE testing in such cases.
Hornstein
L
L
Immunology Laboratory, Lady Davis Carmel Hospital, Haifa, Israel.
Lederer
G
G
Schechter
J
J
Greenberg
Z
Z
Boem
R
R
Bilguray
B
B
Giladi
L
L
Hamburger
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000909:Antibodies, Helminth / Q000032:analysis; D004641:Emigration and Immigration; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012555:Schistosomiasis mansoni / Q000208:ethnology* / Q000276:immunology / Q000469:parasitology; D015006:Yemen / Q000208:ethnology
D000909:Antibodies, Helminth; D007073:Immunoglobulin E