title: Acute and long-term effects of viral bronchiolitis in infancy.
abstract: About 1% of infants are admitted to hospital with acute bronchiolitis; 85% of cases are caused by infection with Respiratory Syncytial Virus (RSV). The pathophysiological changes during the acute illness are inflammatory obstruction in the small airways with submucosal cellular infiltration, epithelial necrosis and mucous plugging; FRC increases and dynamic compliance falls. Failure to respond to bronchodilator drugs suggests that muscle spasm contributes relatively little to the airway narrowing. Affected infants become increasingly dyspnoeic and hypoxic for 3-4 days then spontaneously improve. After an attack of acute bronchiolitis up to 75% of children have recurrent lower respiratory tract symptoms, many continue to have hyperinflated lungs and bronchial hyperresponsiveness. In the majority, symptoms of cough and wheezing have subsided by the time they start school, but abnormalities of small airway function are detectable at least 13 years later. Children with a genetic predisposition to atopy do not appear to have an increased risk of developing bronchiolitis. Evidence of genetic predisposition to bronchial hyperresponsiveness in those with persistent wheezing is controversial. There is little to suggest that neonatal lung damage or an adverse home environment are important factors in determining susceptibility to post-bronchiolitis wheezing. IgE antibodies to RSV, and leukotriene C4, are found more frequently in the respiratory secretions of infants who wheeze during and after bronchiolitis than in those who do not. The possibility of viral-induced alteration of the immune response at the time of infection needs further investigation.
authors.affiliation: Department of Child Health, King's College Hospital, London, United Kingdom.
authors.forename: J F
authors.initials: JF
authors.lastname: Price
mesh_terms: D001985:Bronchial Provocation Tests; D001990:Bronchiolitis, Viral / Q000150:complications*; D003371:Cough / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D012130:Respiratory Hypersensitivity / Q000209:etiology; D012135:Respiratory Sounds / Q000209:etiology; D012136:Respiratory Syncytial Viruses / Q000472:pathogenicity; D010253:Respirovirus Infections / Q000150:complications*