title: [Diabetes, malnutrition and growth retardation].
abstract: We investigated the cellular mechanisms responsible for growth hormone (GH) resistance in diabetes and malnutrition in the rat. In insulin-dependent diabetes, a post-receptor defect participates in GH resistance. During fasting, there is a loss of liver GH binding sites. Dietary protein restriction causes a post-receptor defect. This defect can be attributed to the combined effects of decreased liver IGF-I mRNA content and impaired message translation.
authors.affiliation: Unité de Diabétologie et Nutrition, Faculté de Médecine, l'Université catholique de Louvain-en-Woluwe.
authors.forename: J M
authors.initials: JM
authors.lastname: Ketelslegers
authors.forename: M
authors.initials: M
authors.lastname: Maes
authors.forename: D
authors.initials: D
authors.lastname: Maiter
authors.forename: J P
authors.initials: JP
authors.lastname: Thissen
authors.forename: S
authors.initials: S
authors.lastname: Triest
authors.forename: L E
authors.initials: LE
authors.lastname: Underwood
authors.forename: A E
authors.initials: AE
authors.lastname: Lambert
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005215:Fasting / Q000378:metabolism; D006130:Growth Disorders / Q000378:metabolism*; D013006:Growth Hormone / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats; D011986:Receptors, Somatotropin / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism
chemical_list: D011986:Receptors, Somatotropin; D013002:Somatomedins; D013006:Growth Hormone
vernacular_title: Diabète, malnutrition et retard de croissance.