Development of a laboratory robotic system for automated bioanalytical methods--II. A robot computer program for guarding totally automated bioanalytical methods.
The application of fully automated, unattended sample preparation performed by a laboratory robot for the analysis of drugs in biological samples requires the prevention of system failures which may arise in the on-line coupled chromatographic system or in other components of the robotic system. A computer program has been developed which can help to detect such problems. The control program for the robotic sample preparation contains a number of safety measures to intercept robotic or human errors. A routine is implemented, guarding for chromatographic malfunctions and errors in dispensing liquids by the robot. After detection of trouble, sample preparation is interrupted.
Wieling
J
J
Pharma Bio-Research International B.V., Assen, The Netherlands.
Hempenius
J
J
Jeuring
H J
HJ
Jonkman
J H
JH
Coenegracht
P M
PM
Doornbos
D A
DA
D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003201:Computers; D006801:Humans; D012371:Robotics; D012984:Software; D013806:Theophylline / Q000097:blood*
D013806:Theophylline