[Changes in the glycolytic pathway in patients with essential arterial hypertension].
The defect of the sodium pump of the blood cell membrane in patients with essential blood hypertension, can induce changes in the metabolic use of ATP, especially at glucolytic pathway level. We studied the blood levels of ATP (32.51 +/- 10.80 mg/100 ml), 2,3-DPG (0.82 +/- 0.47 mumol/ml), piruvate (0.36 +/- 0.16 mg/100 ml) and lactate (18.88 +/- 4.53 mg/dl), of a group of 50 patients with essential blood hypertension and of 50 healthy persons in the control group (17.09 +/- 6.37 mg/100 ml, 0.45 +/- 0.23 mumol/ml, 0.33 +/- 0.15 mg/100 ml and 17.32 +/- 3.85 mg/dl respectively). There were statistically significant differences between ATP (p less than 0.0005) levels and 2,3-DPG and lactate (p less than 0.05). These results force us to study the presence of those changes on peripheral tissues to see whether they play an important role in hypertension complications, especially in respect of the vascular wall.
Pérez Cano
R
R
Departamento de Medicina, Hospital Clínico Universitario, Sevilla.
Murillo del Castillo
C
C
Moruno García
R
R
Oliván Martínez
J
J
Montoya García
M
M
Galan Galán
F
F
Garrido Peralta
M
M
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000368:Aged; D004163:Diphosphoglyceric Acids / Q000097:blood; D006019:Glycolysis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid
D004163:Diphosphoglyceric Acids; D007773:Lactates; D011773:Pyruvates; D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate
Alteraciones de la vía glucolítica en pacientes con hipertensión arterial esencial.