Influence of co-dergocrine on platelet aggregation.
In the present investigation, we studied the influence of co-dergocrine mesylate (dihydroergotoxin mesylate) on platelet aggregation induced by adrenaline, adenosine diphosphate (ADP) and collagen in vitro. Platelet-rich plasma was incubated with increasing concentrations of co-dergocrine (1.5, 3.0, 6.0, 12.0, 24.0, and 48.0 micrograms/ml). The lowest concentration of co-dergocrine tested (1.5 micrograms/ml) inhibited adrenaline-induced aggregation by 97%. Higher concentrations of the compound caused similar degrees of inhibition. ADP-induced aggregation was only decreased significantly (20%, P less than 0.001) by the highest concentration of co-dergocrine, whereas collagen-induced aggregation was not affected. Our results demonstrate that co-dergocrine selectively inhibits platelet aggregation triggered by adrenaline in vitro.
Santos
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Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Brasil.
Rodrigues
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D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors*; D003094:Collagen / Q000037:antagonists & inhibitors*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D004088:Dihydroergotoxine; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine