[Drug surveillance for adverse reactions in patients with human immunodeficiency virus infection].
Human immunodeficiency virus (HIV) carrier patients experience several secondary effects with drugs, being mainly skin reactions and myelosuppression. Owing to this, close observation of patients is necessary with regard to therapeutic and prophylactic schedules. In this paper, we describe the secondary effects of zidovudine in 60 patients of groups III and IV from CDC. The main toxicity was found in bone marrow; with anemia in 50% and leukopenia in 53% of patients. Finally, the more frequent secondary effects of therapy for opportunist infections are analysed. A guide for identifying the drugs' secondary effects is also included, based on our experience and on a wide range of literature reviews.
Valencia
M E
ME
Servicio de Medicina Interna, Hospital La Paz, Madrid.
Gil
A
A
Lavilla
P
P
Pintado
V
V
López Dupla
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000666:Amphotericin B / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D015774:Ganciclovir / Q000009:adverse effects; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D010419:Pentamidine / Q000009:adverse effects; D011358:Product Surveillance, Postmarketing; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects; D015215:Zidovudine / Q000009:adverse effects
D000995:Antitubercular Agents; D015215:Zidovudine; D010419:Pentamidine; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015774:Ganciclovir
Farmacovigilancia de reacciones adversas en pacientes con infección por el virus de la inmunodeficiencia humana.