title: Over-reinforcement protects against memory deficits induced by muscarinic blockade of the striatum.
abstract: It has been shown that blockade of muscarinic receptors of the anterior striatum (AS) induces significant impairments in the retrieval of stored information of a passive avoidance task, trained with conventional parameters of footshock, and that the same blockade is ineffective in altering short-term memory of this task. The results of the present experimental series showed that in conditions of over-reinforcement, microinjections of scopolamine into the AS shortly after training or before retention testing of passive avoidance, do not produce memory deficits when retention is assessed 30 min, 24 h or 48 h after training. It is suggested that after an enhanced learning experience (over-reinforcement) striatal cholinergic activity is not involved in short- and long-term memory functions.
authors.affiliation: Laboratorio de Psicofisiología, Universidad Veracruzana, Xalapa, Ver., México.
authors.forename: M A
authors.initials: MA
authors.lastname: Díaz del Guante
authors.forename: S
authors.initials: S
authors.lastname: Rivas-Arancibia
authors.forename: G
authors.initials: G
authors.lastname: Quirarte
authors.forename: R A
authors.initials: RA
authors.lastname: Prado-Alcalá
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D012054:Reinforcement, Psychology; D012601:Scopolamine / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D011976:Receptors, Muscarinic; D012601:Scopolamine