title: The management of heart transplant recipients treated with cyclosporine in Ireland: monitoring of cyclosporine concentrations in blood.
abstract: Thirty seven cardiac transplants have taken place at the National Cardiac Centre in Ireland since 1985. Data is presented on three still-surviving male patients aged 19 to 42 who received cardiac transplants in 1985 and 1986. Circulating levels of blood cyclosporine were measured by high pressure liquid chromatography and radioimmunoassay; plasma creatinine and bilirubin were also measured. In one of these patients the distribution of cyclosporine in blood was measured by high pressure liquid chromatography in a long term study. For all three patients cyclosporine levels in blood were compared with the daily dose of cyclosporine and biochemical and histopathological parameters.
authors.affiliation: Department of Biochemistry, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: F
authors.initials: F
authors.lastname: Kyne
authors.forename: S
authors.initials: S
authors.lastname: Maguire
authors.forename: D
authors.initials: D
authors.lastname: UaConaill
authors.forename: S
authors.initials: S
authors.lastname: O'Broin
authors.forename: E
authors.initials: E
authors.lastname: Clarke
authors.forename: S
authors.initials: S
authors.lastname: McCann
authors.forename: P
authors.initials: P
authors.lastname: Dervan
authors.forename: A E
authors.initials: AE
authors.lastname: Wood
mesh_terms: D000328:Adult; D001706:Biopsy; D002851:Chromatography, High Pressure Liquid / Q000592:standards*; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005069:Evaluation Studies as Topic; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D010949:Plasma / Q000737:chemistry; D011863:Radioimmunoassay / Q000592:standards*; D012680:Sensitivity and Specificity
chemical_list: D003524:Cyclosporins