[The effect of antibiotics and immunostimulants on rickettsial persistence in experimental typhus infection].
A model of experimental typhus infection has shown that not only specific protection factors but also nonspecific ones are very important to remove Rickettsia prowazekii from macroorganisms. A complex application of antibiotics and drugs increasing immunobiological reactivity of the organism (prodigiosan, methyl uracil) noticeably decreases the rickettsia persistence level in the organism of experimental animals, the indices of specific and nonspecific protection being increased.
Klimchuk
N D
ND
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D011354:Prodigiozan / Q000627:therapeutic use; D012283:Rickettsia prowazekii / Q000187:drug effects* / Q000302:isolation & purification; D012293:Rifampin / Q000627:therapeutic use; D014438:Typhus, Epidemic Louse-Borne / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D014498:Uracil; C008378:6-methyluracil; D011354:Prodigiozan; D004318:Doxycycline; D012293:Rifampin
Vliianie antibiotikov i immunostimuliatorov na persistirovanie rikketsiĭ pri éksperimental'noĭ sypnotifoznoĭ infektsii.