Stimulated platelets release amyloid beta-protein precursor.
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid beta-protein precursor could be involved in normal platelet physiology.
Cole
G M
GM
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.
Galasko
D
D
Shapiro
I P
IP
Saitoh
T
T
D000682:Amyloid / Q000276:immunology / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D001792:Blood Platelets / Q000378:metabolism*; D015153:Blotting, Western; D006801:Humans; D066298:In Vitro Techniques; D015759:Ionomycin / Q000494:pharmacology; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology*; D011498:Protein Precursors / Q000276:immunology / Q000378:metabolism*; D013917:Thrombin / Q000494:pharmacology
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D011498:Protein Precursors; D015759:Ionomycin; D013917:Thrombin