title: Effects of ozone exposure on experimental asthma in guinea pigs sensitized with ovalbumin through the airway.
abstract: As ozone (O3) is known to cause airway inflammation and hyperresponsiveness, we examined the effects of O3 exposure (1, 3, or 5 ppm, 2 h) on sensitization and provocation in guinea pigs sensitized with ovalbumin (OA) through the airway. In groups exposed to O3 before sensitization, 5 ppm increased the production of IgG1 antibodies and decreased the OA sensitization threshold from 0.01 to 0.002%. In those exposed before provocation, 1, 3, or 5 ppm of O3 decreased the OA provocation threshold from 0.5 to 0.02%, and this enhancement appeared to depend on airway hyperresponsiveness. We conclude that O3 exposure may play an important role in causing asthmatic attacks rather than enhancing allergic sensitization.
authors.affiliation: First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sumitomo
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Okubo
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D001249:Asthma / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D010047:Ovalbumin / Q000276:immunology*; D010126:Ozone / Q000633:toxicity*
chemical_list: D007074:Immunoglobulin G; D010126:Ozone; D010047:Ovalbumin