title: Fertility in couples heterozygous for the tyrosinemia gene in Saguenay Lac-St-Jean.
abstract: A case-control study of 84 couples from Saguenay-Lac-St-Jean, jointly heterozygous for the tyrosinemia gene, was done to determine whether the birth of an homozygous child affected their fertility rates. The mean number of children born to tyrosinemia and control couples between 1940 and 1986 was not different (p greater than 0.05). The knowledge that tyrosinemia was an autosomal recessive disorder, with risk of recurrence in these families, did not appear to modify reproductive behaviour. Fertility fell significantly in both the tyrosinemia and control families in the period of observation. This change reflects the decline in fertility of French Canadians in general during this period.
authors.affiliation: Inter-University Center for Research on Populations (SOREP), Université du Quebec, Chicoutimi, Canada.
authors.forename: M
authors.initials: M
authors.lastname: De Braekeleer
authors.forename: V
authors.initials: V
authors.lastname: Lamarre
authors.forename: C R
authors.initials: CR
authors.lastname: Scriver
authors.forename: J
authors.initials: J
authors.lastname: Larochelle
authors.forename: G
authors.initials: G
authors.lastname: Bouchard
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000235:genetics* / Q000517:prevention & control; D016022:Case-Control Studies; D005191:Family Characteristics; D005260:Female; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011792:Quebec; D014443:Tyrosine / Q000097:blood*
chemical_list: D014443:Tyrosine