A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells.
We describe the cloning and characterization of the mouse MOK-2 gene, a new member of the Krüppel family of zinc finger proteins. Sequencing of both cDNA and genomic clones showed that the predicted MOK-2 protein consists of seven zinc finger domains with only five additional amino acids. The finger domains of MOK-2 are highly homologous to one another but not to those of other zinc finger proteins. MOK-2 is preferentially expressed in transformed cell lines, brain tissue, and testis tissue. Its possible role in cellular transformation is discussed.
Ernoult-Lange
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M
Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892.
Kress
M
M
Hamer
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D008667:Metalloproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping
D004268:DNA-Binding Proteins; D008667:Metalloproteins; D012333:RNA, Messenger