title: Ovulation induction and pregnancies in 100 consecutive women with hypergonadotropic amenorrhea.
abstract: The efficacy of a technique of gonadotropin suppression and human menopausal gonadotropins (hMG) to induce ovulation in women with hypergonadotropic amenorrhea was evaluated in 100 consecutive women. Ovulation was achieved in 19% of cycles (68/361), the pregnancy rate per cycle was 5.2% (19/361), and the viable pregnancy rate was 2.2% (8/361). In the majority of the successful cases, estrogen was used to decrease the elevated luteinizing hormone and follicle-stimulating hormone levels, especially where the ethinyl estradiol therapy alone induced a rise in endogenous 17 beta-estradiol levels with hMG used to boost the follicle to maturation. Although the success rate is low, this technique can result in some successes in otherwise almost hopeless cases.
authors.affiliation: University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden.
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: K
authors.initials: K
authors.lastname: Nowroozi
authors.forename: J S
authors.initials: JS
authors.lastname: Chase
authors.forename: A
authors.initials: A
authors.lastname: Nazari
authors.forename: D
authors.initials: D
authors.lastname: Shapse
authors.forename: M
authors.initials: M
authors.lastname: Vaze
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004967:Estrogens / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006062:Gonadotropins / Q000097:blood; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000503:physiopathology / Q000628:therapy*; D016729:Leuprolide; D008596:Menotropins / Q000627:therapeutic use; D008875:Middle Aged; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors
chemical_list: D004967:Estrogens; D006062:Gonadotropins; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D004997:Ethinyl Estradiol; D008596:Menotropins; D016729:Leuprolide