Inhibition of ornithine-decarboxylase produced by S(+) and R(-) ibuprofen in rats.
The differences between the S(+) and R(-) ibuprofen enantiomers in anti-inflammatory activity were assayed by measuring the release of 14CO2 in rats treated with labelled 14COOH-ornithine. Furthermore we investigated in vitro the inhibitory activity on ornithine-decarboxylase and the anti-inflammatory activity of R(-) and S(+) ibuprofen by using the carrageenin-induced paw oedema test in the rat.
Bruni
G
G
Institute of Pharmacology, University of Siena, Italy.
Runci
F M
FM
Fiaschi
A I
AI
Segre
G
G
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004926:Escherichia coli / Q000201:enzymology; D007052:Ibuprofen / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D065108:Ornithine Decarboxylase Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D065108:Ornithine Decarboxylase Inhibitors; D002245:Carbon Dioxide; D002351:Carrageenan; D007052:Ibuprofen