A genotoxicological study of the new local anaesthetic carbamate derivatives carbisocaine, heptacaine and pentacaine.
The potential mutagenic activity of three carbamate derivatives with local anaesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster.
Siekel
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Institute of Biochemistry and Biotechnology, Comenius University, Bratislava, Czechoslovakia.
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D002219:Carbamates / Q000633:toxicity; D004260:DNA Repair / Q000187:drug effects; D004331:Drosophila melanogaster / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005055:Euglena / Q000187:drug effects / Q000235:genetics; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D010880:Piperidines / Q000633:toxicity; D012486:Salmonella typhimurium / Q000235:genetics
D000779:Anesthetics, Local; D002219:Carbamates; D009153:Mutagens; D010880:Piperidines; C013549:heptacaine; C010618:pentacaine; C046030:carbizocaine