title: Treatment failure in trichomoniasis and persistence of the parasite after Lactobacillus immunotherapy; two case reports.
abstract: This report describes the clinical and laboratory observations on two patients with a Trichomonas vaginalis infection resistant to metronidazole. The metronidazole resistance was confirmed in in vitro cultures under aerobic conditions, after in vitro cultivation of the strains. Trichomonas infection persisted during high-dose intravenous metronidazole administration and Lactobacillus immunotherapy was unsuccessful in both patients.
authors.affiliation: Department of Obstetrics and Gynaecology, St. Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: van der Weiden
authors.forename: W I
authors.initials: WI
authors.lastname: van der Meijden
authors.forename: D H
authors.initials: DH
authors.lastname: Bogchelman
authors.forename: A M
authors.initials: AM
authors.lastname: Polderman
mesh_terms: D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007779:Lactobacillus acidophilus; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000188:drug therapy / Q000469:parasitology / Q000628:therapy*
chemical_list: D008795:Metronidazole