Nuclear magnetic resonance spectra and molecular structure of mesna.
Mesna (2-mercapto-ethane sulfonic acid sodium salt) is used as a reliably acting uroprotector in cancer chemotherapy with oxazaphosphorine cytostatics. 1H-, 13C[1H]- and C,H-COSY-NMR-spectra are analyzed. In solution state mesna exists predominantly in a trans-rotameric form. These findings are supported by hypothetical gas-phase-structures of mesna, simulated via the program system MOPAC.
Hägele
G
G
Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, Fed. Rep. of Germany.
Batz
M
M
Peters
R
R
Niemeyer
U
U
Engel
J
J
D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000032:analysis*; D008956:Models, Chemical; D015394:Molecular Structure
D008623:Mercaptoethanol; D015080:Mesna