[The comparative characteristics of the immunomodulating properties of protein A from Staphylococcus aureus of different origins].
The immunomodulating properties of highly purified staphylococcal protein A and its analog obtained by gene engineering techniques have been compared with those of commercial preparations. The comparison has shown that the differences observed in this investigation may be explained by the presence of admixtures of staphylococcal nature in commercial preparations. The preparations of highly purified staphylococcal and recombinant protein A stimulate humoral immune response and the processes of phagocytosis and do not show mitogenic activity with respect to T cells. The conclusion on the identity of the immunomodulating activity of the preparations of natural and recombinant protein A has been made.
Kondakov
K E
KE
Semenkova
L N
LN
Kosarev
I V
IV
Surovtseva
V M
VM
Surovtsev
V I
VI
Galaktionov
V G
VG
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology / Q000302:isolation & purification; D013205:Staphylococcal Protein A / Q000276:immunology* / Q000302:isolation & purification
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D011994:Recombinant Proteins; D013205:Staphylococcal Protein A
Sravnitel'naia kharakteristika immunomoduliruiushchikh svoĭstv belka A Staphylococcus aureus razlichnogo proiskhozhdeniia.