Influence of central and peripheral norepinephrine on the antibody response.
This paper intends to study the effect on the antibody response of profound, or mild variations of (central and peripheral) noradrenergic activity. An intraperitoneal injection of 6-hydroxydopamine (100 mg/kg) at the time of immunization impaired the anti-sheep-erythrocyte antibody response in both normal mice and in mice previously denervated with 6-hydroxydopamine; treatment with 6-hydroxydopamine, 7 days before immunization, did not affect the response. This suggests either a direct effect of the neurotoxin on the antibody response or an indirect effect via denervation and supersensitivity. Therapeutic doses of guanethidine (0.5-2.5 mg/kg) which do not damage the adrenergic axons, affected marginally and transiently the antibody response to sheep erythrocytes. Intracisternal injection of 6-hydroxydopamine (a 75-ug pulse, or three 25-ug pulses), DSP4 (a 75-ug pulse), or guanethidine (three 100-ug pulses) did not alter either the anti-trinitrophenyl natural-antibody response or the anti-sheep-erythrocyte antibody response. Swimming (at 32 degrees C) transiently and slightly enhanced the anti-sheep-erythrocyte (IgM) antibody response. It is proposed that the physiological fluctuations in the level of (central or peripheral) noradrenergic activity transiently and minimally influence the antibody response.
Vidal
J
J
Department of Microbiology and Immunology, A.B. Chandler Medical Center, University of Kentucky, Lexington.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001596:Benzylamines / Q000494:pharmacology; D002490:Central Nervous System / Q000502:physiology*; D002946:Cisterna Magna; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D007274:Injections, Intraperitoneal; D051379:Mice; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D010525:Peripheral Nerves / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology; D013563:Sympathectomy, Chemical; D013566:Sympathomimetics / Q000494:pharmacology
D001596:Benzylamines; D006892:Hydroxydopamines; D013566:Sympathomimetics; D016627:Oxidopamine; C012102:DSP 4; D009638:Norepinephrine; D006145:Guanethidine