[The nature of the pancreatic hormone secretion and of the metabolic indices during the acute and chronic administration of peroral hypoglycemic preparations].
A comparative study of the effect of acute and chronic administration of sulfanilureal sugar lowering drugs (glipizide and glibenclamide) on the secretion of the pancreatic hormones, indices of microcirculation, the level of triglycerides and nonesterified fatty acids was conducted. Patients with primary detected diabetes mellitus with normal body mass and obesity of I-III degrees were investigated. The principal differences in insulinotropic action of sugar lowering drugs in various groups of patients and significant differences in the mechanism of their hypoglycemic action at varying time of treatment indicate the necessity of a strictly differentiated approach to subscription of these drugs for patients with primary detected diabetes mellitus.
Belovalova
I M
IM
Gamburtseva
T D
TD
Kniazeva
A P
AP
Matveeva
L S
LS
Starosel'tseva
L K
LK
D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D004341:Drug Evaluation; D005913:Glipizide / Q000008:administration & dosage; D005905:Glyburide / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008875:Middle Aged; D009765:Obesity; D010187:Pancreatic Hormones / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D007004:Hypoglycemic Agents; D010187:Pancreatic Hormones; D005905:Glyburide; D005913:Glipizide
Izuchenie kharaktera sekretsii gormonov podzheludochnoĭ zhelezy i nekotorykh metabolicheskikh pokazateleĭ pri ostrom i khronicheskom vvedenii peroral'nykh sakharoponizhaiushchikh preparatov.