Indirect continuous automatic determination of pharmaceuticals by atomic absorption spectroscopy.
The implementation of continuous separation techniques such as precipitation, liquid-liquid and solid-liquid extraction in FIA manifolds coupled on-line with an atomic absorption spectrometer for the determination of active components (sulphonamides, local anaesthetics, amphetamines, benzodiazepines, chloramphenicol and methadone) in pharmaceuticals and biological fluids is systematically described. The basic features of the analytical methodologies described (sensitivity, selectivity, precision and rapidity) are also discussed and critically compared.
Valcárcel
M
M
Department of Analytical Chemistry, University of Córdoba, Spain.
Gallego
M
M
Montero
R
R
D000662:Amphetamines / Q000032:analysis; D000779:Anesthetics, Local / Q000032:analysis; D001322:Autoanalysis; D001960:Bromazepam / Q000032:analysis; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013054:Spectrophotometry, Atomic / Q000295:instrumentation*; D013449:Sulfonamides / Q000032:analysis
D000662:Amphetamines; D000779:Anesthetics, Local; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D013449:Sulfonamides; D001960:Bromazepam