title: Gonadotropin response by postpartum mares to gonadotropin-releasing hormone.
abstract: We hypothesized that the LH response to GnRH would be greater as the interval from foaling increases, whereas the FSH response would decrease, and that corpus luteum function after the first ovulation would be similar to that after the second ovulation. At parturition, mares were assigned to receive GnRH (2 micrograms/kg) intravenously on 1) d 3 postpartum (n = 6); 2) d 6 postpartum (n = 6); 3) d 1 of first postpartum estrus (foal estrus) and again on d 1 of second postpartum estrus (n = 8). Blood was collected through an indwelling cannula at -2, -1 and 0 h relative to GnRH stimulation (basal concentrations) and at .25, .5, .75, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5 and 4.0 h post-GnRH. Samples were assayed for concentrations of LH and FSH. Basal concentrations of LH were lower (P less than .05) for mares given GnRH on d 3 postpartum than for mares on d 1 of foal estrus. A rise in concentrations of LH was noted within 30 min in all groups, but the response to GnRH on d 1 of the first estrus was less (P less than .05) than on d 1 of second postpartum estrus. As the interval from parturition increased, the amount of LH secreted in response to GnRH increased. The maximum response to GnRH was greater (P less than .05) during d 1 of the first estrus than on d 3 or 6 postpartum and was greater on d 1 of cycle 2 than on d 1 of cycle 1.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Colorado State University, Fort Collins 80523.
authors.forename: L A
authors.initials: LA
authors.lastname: Harrison
authors.forename: E L
authors.initials: EL
authors.lastname: Squires
authors.forename: T M
authors.initials: TM
authors.lastname: Nett
authors.forename: A O
authors.initials: AO
authors.lastname: McKinnon
mesh_terms: D000818:Animals; D004971:Estrus / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D006736:Horses / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D049590:Postpartum Period / Q000378:metabolism*; D011897:Random Allocation
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone