title: Infant botulism: case report and clinical update.
abstract: Infant botulism occurs in infants between 1 week and 11 months of age and results from the in vivo production of neurotoxin by Clostridium botulinum. The clinical spectrum ranges from asymptomatic carriers, through various degrees of paralysis, to sudden death. The classic clinical presentation is an afebrile child with constipation and generalized weakness manifested by poor head control, poor suck, and weak cry. Symptoms can progress to include cranial nerve palsies, respiratory arrest, and adynamic ileus. Treatment is supportive in an intensive care setting. Antibiotics and antitoxin are not indicated. The morbidity and mortality is less than 3% in hospitalized patients and complete recovery can be expected. The environmental and dietary factors associated with infection are discussed.
authors.affiliation: Department of Emergency Medicine, Bethesda Naval Hospital, MD.
authors.forename: A
authors.initials: A
authors.lastname: Jagoda
authors.forename: G
authors.initials: G
authors.lastname: Renner
mesh_terms: D001906:Botulism / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003014:Clostridium botulinum / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D010289:Parenteral Nutrition, Total; D010406:Penicillins / Q000627:therapeutic use; D011379:Prognosis; D013396:Suction
chemical_list: D010406:Penicillins