title: Histiocytosis-X: role of histology and S-100 protein in grading the severity of disease.
abstract: Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.
authors.affiliation: Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.
authors.forename: S Y
authors.initials: SY
authors.lastname: Sane
authors.forename: K H
authors.initials: KH
authors.lastname: Nainaney
mesh_terms: D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D009418:S100 Proteins