Serum CA-125 levels do not depend on ovarian steroidogenesis.
To investigate the relationship between CA-125 production and ovarian steroidogenesis, serum CA-125 levels were evaluated in patients with normal pelvis in different ovarian endocrine situations: (1) during the menstrual cycle, (2) during stimulatory treatment with gonadotropin for the induction of ovulation, and (3) during suppression treatment with gonadotropin-releasing hormone agonists. In spite of the spontaneous or the markedly induced variations of estradiol (E2) or ovarian volume, CA-125 levels remained unvaried in all patients. Moreover, CA-125 serum levels did not correlate with the increasing values of the plasma E2 or ovarian volume. In conclusion, steroidogenetic activity of the ovary is unlikely to affect CA-125 production.
Lanzone
A
A
Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Fulghesu
A M
AM
Guida
C
C
Muscatello
R
R
Caruso
A
A
Mancuso
S
S
D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002064:Buserelin / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies
D015295:Antigens, Tumor-Associated, Carbohydrate; D004958:Estradiol; D002064:Buserelin