Experience with partial liver transplantation in Hannover.
Within a 7-year period 37 PLTx have been performed in 32 patients (25 children, 7 adults). Age at the time of operation was 5 years in two-thirds of all cases (23 of 37). Indications were elective in 17 patients and urgent in 20. The following types of PLTx were used: a LLL in 24 cases, a LL in 9, and a RL in 4. Three donor livers were split and transplanted into 2 recipients each. The body weight ratio between donors and recipients ranged from 0.9:1 to 12.3:1. Nineteen of 26 adult-donor livers were transplanted into pediatric recipients. Patient and graft survival following elective PLTx at 2 years was 69.7% and 50.5%, respectively, which was not significantly different from the results following urgent transplantation. Overall, 30-day mortality was 18.8% (6 of 32 patients) and was relative to the patients' clinical status at the time of transplantation. Graft loss in 29.7% (11 of 37 transplants) was due to liver-related causes such as chronic rejection (n = 5) and primary nonfunction (n = 4). Postoperative surgical complications were noted in 13 cases but were not different from those seen with WLTx. At present, 19 of 32 recipients (59.4%) are alive between 1 and 43 months following transplantation.
Ringe
B
B
Medizinische Hochschule Hannover, Klinik für Abdominal- und Transplantationschirurgie, Germany.
Burdelski
M
M
Rodeck
B
B
Pichlmayr
R
R
D000293:Adolescent; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005858:Germany; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D016031:Liver Transplantation / Q000379:methods* / Q000502:physiology; D012189:Retrospective Studies; D014019:Tissue Donors