Effects of antiepileptic drugs and organic brain damage on SCE frequency in cerebral palsies.
In order to assess the genotoxic effects of antiepileptic drugs (AEDs), analysis of sister chromatid exchanges (SCEs) was performed in lymphocytes of three groups of males; epileptics with AED therapy, non-epileptics without AED therapy and healthy controls. The epileptics and non-epileptics were cases of severe cerebral palsies due to perinatal asphyxia. Possible confounding factors of SCE frequencies, such as age, smoking habit, drug usage other than AED, recent history of viral infection, etc. were controlled. The frequency of SCE per cell was 4.63 +/- 0.71 (mean +/- S.D.) in epileptics, 4.70 +/- 0.89 in non-epileptics and 3.84 +/- 0.56 in healthy controls. SCEs in both epileptics and non-epileptics were significantly higher (p less than 0.05) than those in controls. There was no significant difference of SCE frequency between epileptics and non-epileptics. These results suggested that no mutagenic effect of AED could be demonstrated as revealed by SCEs, and organic brain damage per se might influence the baseline SCE frequency. The possible explanations for such observations are discussed.
Yamamoto
K
K
Department of Pediatrics, National Nishitaga Hospital, Sendai, Japan.
Kohnosu
T
T
Nakagawara
K A
KA
Sakai
K
K
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002478:Cells, Cultured; D002547:Cerebral Palsy / Q000150:complications / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D012016:Reference Values; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000927:Anticonvulsants