title: Carcinogenesis induced by black pepper (Piper nigrum) and modulated by vitamin A.
abstract: Painting and feeding of mice with 2mg of an extract from black pepper on 3 days a week for 3 months results in a significant increase of the number of tumor-bearing mice. Tumor incidence is reduced in those groups of experimental animals receiving 5 or 10mg Vitamin A-palmitate twice weekly for 3 months by feeding or painting during and subsequent to application of pepper extract. Feeding of mice with powder of black pepper in diet (50g/3kg food) has no impact on carcinogenesis.
authors.affiliation: Zoology Department, Faculty of Science, Alexandria University, Egypt.
authors.forename: M H
authors.initials: MH
authors.lastname: Shwaireb
authors.forename: H
authors.initials: H
authors.lastname: Wrba
authors.forename: M M
authors.initials: MM
authors.lastname: el-Mofty
authors.forename: A
authors.initials: A
authors.lastname: Dutter
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003212:Condiments / Q000633:toxicity; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010936:Plant Extracts / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D014801:Vitamin A