title: IgG and IgM antibodies immunoreacting with a 2,3-diacyl trehalose-2'-sulphate in sera from leprosy patients.
abstract: The distribution of IgG and IgM antibodies immunoreacting with the sulpholipid I (SLI) and sulpholipid IV (SLIV) of Mycobacterium tuberculosis was examined in sera from leprosy patients. It was found that the immunological reactions correlated with the clinical spectrum of leprosy; and in multibacillary patients, antibody titres declined in response to successful treatment. The serological patterns were similar to the PGL I patterns, however, the IgG responses towards the sulpholipids were predominant over the IgM responses in the case of the sulpholipid antigens.
authors.affiliation: Unité de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Cruaud
authors.forename: M C
authors.initials: MC
authors.lastname: Potar
authors.forename: H L
authors.initials: HL
authors.lastname: David
authors.forename: F
authors.initials: F
authors.lastname: Papa
authors.forename: J
authors.initials: J
authors.lastname: Torgal-Garcia
authors.forename: F
authors.initials: F
authors.lastname: Maroja
authors.forename: A T
authors.initials: AT
authors.lastname: Orsi-Souza
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology; D004187:Disaccharides; D004797:Enzyme-Linked Immunosorbent Assay; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007918:Leprosy / Q000276:immunology*; D009166:Mycobacterium leprae / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014199:Trehalose / Q000031:analogs & derivatives
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004187:Disaccharides; D006017:Glycolipids; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C045169:phenolic glycolipid I, Mycobacterium leprae; D014199:Trehalose