Influence of diuretics on brachial artery diameter and distensibility in hypertensive patients.
Blood pressure, brachial artery diameter and pulse wave velocity were determined before and after diuretic treatment in 2 groups of hypertensive patients treated either by indapamide (2.5 mg per d) or by canreonate (50 mg per d). Brachial artery diameter, measured from pulsed Doppler flowmetry, and pulse wave velocity, evaluated from mechanography, did not alter significantly despite a significant blood pressure reduction. The study indicates that, in hypertensive patients of middle age, diuretics did not change brachial artery diameter and distensibility, whether the drug caused an increase or a decrease in plasma potassium levels.
Laurent
S
S
Department of Internal Medicine, Broussais Hospital, Paris, France.
Lacolley
P M
PM
Cuche
J L
JL
Safar
M E
ME
D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D002191:Canrenoic Acid / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D014463:Ultrasonography
D004232:Diuretics; D002191:Canrenoic Acid; D007190:Indapamide; D011188:Potassium