Transforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression.
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide regulating several processes in ovarian cells. The growth of ovarian carcinoma cell lines (OVCAR-3, HTB-77, 2780 and CRL-1572) was reduced by TGF-beta in a dose related manner. The antiproliferative activity was not improved by combination with other biological response modifiers. Treatment with TGF-beta augmented the expression of interferon-gamma induced class I and II antigens of the major histocompatibility complex. The presentation of another antigen namely the tumor marker CA-125 on the cell surface was markedly reduced by TGF-beta.
Marth
C
C
Department of Obstetrics and Gynecology, Innsbruck University Clinic, Austria.
Lang
T
T
Koza
A
A
Mayer
I
I
Daxenbichler
G
G
D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000037:antagonists & inhibitors; D008285:Major Histocompatibility Complex / Q000187:drug effects; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology*; D011994:Recombinant Proteins / Q000494:pharmacology; D015291:Transforming Growth Factors / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D011994:Recombinant Proteins; D015291:Transforming Growth Factors; D007371:Interferon-gamma