Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
Intravesical instillation of 2-phenyl-1,4-benzoquinone (PBQ), a metabolite of sodium o-phenylphenate (Na-OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor-initiating activity was observed with either Na-OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na-OPP urinary bladder carcinogenesis.
Hasegawa
R
R
Division of Pathology, National Institute of Hygienic Sciences, Tokyo.
Furukawa
F
F
Toyoda
K
K
Sato
H
H
Takahashi
M
M
Hayashi
Y
Y
D000283:Administration, Intravesical; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D001713:Biphenyl Compounds; C004369:2-phenylphenol