Myocardial oxygen supply in coronary artery disease.
In patients with coronary artery disease investigated during cardiac catheterisation, myocardial blood flow and myocardial oxygen consumption were significantly decreased as compared to control patients without signs of coronary artery disease. At the same time left ventricular function was impaired. In addition to regional contraction abnormalities observed in 77% of the patients, mean heart index and mean left ventricular work were diminished and mean enddiastolic pressure elevated. Among the coronary artery disease group, patients with normal blood pressure had a significantly higher left ventricular enddiastolic pressure than patients with hypertension.
Thomas
M
M
Department of Physiology, University of Bonn, FRG.
Grote
J
J
Nitsch
J
J
D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D016277:Ventricular Function, Left / Q000502:physiology