title: Liver biochemical and histological changes with graded amounts of total parenteral nutrition.
abstract: We sought to determine whether an excess in energy intake as total parenteral nutrition would result in liver biochemical and histological changes in the presence of a functional gastrointestinal tract. Three groups of rats were given amounts of total parenteral nutrition that provided either 25% (total parenteral nutrition-25), 100% (total parenteral nutrition-100), or 200% (total parenteral nutrition-200) of a rat's energy requirements. Rat chow and water were available ad libitum. Food intake decreased in proportion to the amount of total parenteral nutrition infused; it ceased with total parenteral nutrition-200. Liver glycogen and triglyceride concentrations were higher with high energy intake (total parenteral nutrition-100 and total parenteral nutrition-200), while total liver nitrogen concentrations remained unchanged. No cholestasis, inflammation, or fibrosis was seen histologically. Fatty vacuoles were increased with total parenteral nutrition (more so with total parenteral nutrition-200) but a prompt return to normal liver features was observed after cessation of total parenteral nutrition and the resumption of normal food intake.
authors.affiliation: Department of Surgery, University Hospital, State University of New York-Health Science Center, Syracuse 13210.
authors.forename: A C
authors.initials: AC
authors.lastname: Campos
authors.forename: A
authors.initials: A
authors.lastname: Oler
authors.forename: M M
authors.initials: MM
authors.lastname: Meguid
authors.forename: T Y
authors.initials: TY
authors.lastname: Chen
mesh_terms: D000818:Animals; D004435:Eating; D002149:Energy Intake; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009751:Nutritional Requirements; D010289:Parenteral Nutrition, Total; D051381:Rats; D011916:Rats, Inbred F344; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; D006003:Glycogen; D009584:Nitrogen