[Change of myocardial glucose and free fatty acid metabolism and effect of electroacupuncture on them during experimental myocardial angina].
This study was designed to observe the effect of electroacupuncture applied at "Neiguan" point on myocardial Glucose (GLU) and Free fatty acid (FFA) metabolism of dogs with experimental myocardial angina, experimental myocardial angina model was set up in 20 healthy mongrel dogs with reducing the volume of blood flow of left anterior descending coronary (LAD) and intracoronary administration of bradykinin. The results showed that arterial-venous difference of glucose (GLUa-v) was increased significantly and arterial-venous difference of free fatty acid (FFAa-v) was decreased significantly after experimental myocardial angina. with prolongation of the period of myocardial ischemia and increase of the times of myocardial angina, in control group, GLUa-v was increased lightly and FFAa-v was markedly decreased (P less than 0.05), this showed that FFA uptake of ischemic myocardium was markedly decreased. Electroacupuncture at bilateral "Neiguan" point resulted significant decrease of GLUa-v and slight increase of FFAa-v. There were statistical significance between the two groups (P less than 0.05) in GLUa-v and FFA-v. Aterial blood free fatty acid had not significant change after experimental myocardial angina and electroacupuncture had not marked effect on it. The above results indicated that experimental myocardial angina result in metabolic disorders of myocardial glucose and free fatty acid. Electroacupuncture may reduce glucose uptake and increase free fatty acid uptake of ischemic myocardium. Thus improved metabolic disorder of ischemic myocardium.
Gao
C
C
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Meng
J
J
Fu
W
W
Song
L
L
D015670:Acupuncture Therapy; D000787:Angina Pectoris / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D004285:Dogs; D015671:Electroacupuncture; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D005947:Glucose