Treatment with pulsatile luteinizing hormone-releasing hormone modulates folliculogenesis in response to ovarian stimulation with exogenous gonadotropins in patients with polycystic ovaries.
Combined treatment with pulsatile LH-RH and hMG, given to eight patients who had anovulation associated with PCO and resistant to CC, significantly reduced the number of large follicles induced by hMG alone. A direct effect of pulsatile LH-RH on the ovary is postulated. This combined treatment eased the problems of multifollicular development, thereby increasing efficiency and reducing complications in patients with PCO stimulated by gonadotropins.
Homburg
R
R
Cobbold Laboratories, Middlesex Hospital, London, United Kingdom.
Kilborn
J
J
West
C
C
Jacobs
H S
HS
D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007016:Hypophysectomy; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000187:drug effects*; D010053:Ovary / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011673:Pulsatile Flow
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins