Pure red cell aplasia following pernicious anemia.
A rare case of pure red cell aplasia (PRCA) in association with pernicious anemia is reported. A 40-year-old man presented with typical clinical and laboratory features of pernicious anemia and received intramuscular injections of vitamin B12, with satisfactory response. Anemia recurred 6 months later despite continued therapy, and the patient was noted to have PRCA, which was treated successfully with two courses of high-dose bolus methylprednisolone therapy. His peripheral mononuclear cells before the therapy suppressed colony formation of early erythroid precursors (BFU-E) from normal bone marrow; such a suppressive effect was not found after recovery from anemia.
Dan
K
K
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Ito
T
T
Nomura
T
T
D000328:Adult; D000752:Anemia, Pernicious / Q000150:complications* / Q000188:drug therapy; D001772:Blood Cell Count; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use
D014805:Vitamin B 12; D008775:Methylprednisolone