Soluble products of Staphylococcus aureus-stimulated blood mononuclear cells in enhancing polymorphonuclear leukocyte degradation of bone.
Rapid, extensive loss of infected bone implies abnormal localized inflammatory cell activity. We have demonstrated, using a live bone Ca-45 release model, that polymorphonuclear leukocytes degrade bone in a dose dependent manner. Staphylococcus aureus-stimulated blood mononuclear leukocytes release soluble products in vitro that enhance that process. Despite the usually accepted roles of osteoclasts and their blood-borne monocytic precursors in normal bone remodelling, these results indicate that considerable early pathological infected bone loss may be attributable to inflammatory polymorphonuclear leukocytes.
Wang
J H
JH
Department of Orthopaedic Surgery, Christchurch School of Medicine, New Zealand.
Rogers
G R
GR
Allardyce
R A
RA
Gillespie
W J
WJ
D000818:Animals; D001862:Bone Resorption; D002118:Calcium / Q000378:metabolism*; D003470:Culture Media; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D051379:Mice; D009504:Neutrophils / Q000502:physiology*; D010019:Osteomyelitis / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism*
D003470:Culture Media; D002118:Calcium