title: Rapid diagnosis of tuberculous meningitis by polymerase chain reaction (PCR).
abstract: Using a rapid and highly sensitive method for the diagnosis of tuberculous meningitis by polymerase chain reaction (PCR), we detected the Mycobacterium tuberculosis genome in CSF of 5 of 6 patients with clinically diagnosed tuberculous meningitis. The genome was not present in CSF from 10 patients with other types of meningitis and 10 normal controls.
authors.affiliation: Department of Neurology, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: O
authors.initials: O
authors.lastname: Onodera
authors.forename: T
authors.initials: T
authors.lastname: Miyatake
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction / Q000379:methods*; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial