Triiodothyronine accelerates the synthesis of synapsin I in developing neurons from fetal rat brain cultured in a synthetic medium.
The effect of Triiodothyronine (T3) on Synapsin I appearance in rat cortical neurons has been investigated in vitro. Neuronal cultures from 16-day-old fetal rat brain grown in the absence of T3, express immunohistochemically detectable Synapsin I at the 14th day in vitro. The addition of the hormone to the culture medium determines an early (at the 7th day in vitro) appearance of fluorescent dots specific for Synapsin I.
Salemi
G
G
Istituto di Neuropsichiatria, Universitá degli Studi di Palermo, Italy.
Ferraro
D
D
Savettieri
G
G
D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D002478:Cells, Cultured; D003470:Culture Media; D005333:Fetus / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D016704:Synapsins; D014284:Triiodothyronine / Q000494:pharmacology*
D003470:Culture Media; D009419:Nerve Tissue Proteins; D016704:Synapsins; D014284:Triiodothyronine