Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates.
New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.
Andreani
A
A
Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
Rambaldi
M
M
Locatelli
A
A
Andreani
F
F
Aresca
P
P
Bossa
R
R
Galatulas
I
I
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D007211:Indoles