title: [Malignant melanoma of the vulva and vagina (a report of 4 cases and review of the literature)].
abstract: Three women with malignant melanocarcinoma of the vulva and one woman with malignant melanocarcinoma of the vagina were treated at the gynecological clinic of the National Oncological Center for the period of 1983-1988. The mean age of the patients was 52 years. In all patients melanocarcinoma was IV-V degree according to Crark as in 2 women it was pigmented, but in 2 women--achromatic. Radical vulvectomy was performed on patients with melanocarcinoma of the vulva as in 2 patients inguino-femoral lymph dissection according to Ducuing was made, but pelvic lymph dissection according to Taussing was performed in 1 woman as well. The operation of Werthaim-Meigs and extirpation of the vagina was performed in the woman with melanocarcinoma of the vagina. Two of the patients died after 13 and 28 months after the primary treatment due to generalization of the process, but 2 of the patients developed a relapse of the disease 10 and 14 months after treatment. Anterior and posterior exenteration of the pelvis was performed in the woman with a relapse of the vaginal melanocarcinoma. Two patients are still alive for a period of 6 and 8 months and chemotherapy continues. A literary review is presented and possibilities for more effective treatment are discussed.
authors.forename: G
authors.initials: G
authors.lastname: Chakalova
authors.forename: T
authors.initials: T
authors.lastname: Kŭrlov
authors.forename: A
authors.initials: A
authors.lastname: Karag'ozov
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D011182:Postoperative Care; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014844:Vulva / Q000601:surgery; D014846:Vulvar Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine
vernacular_title: Malignen melanom na vulvata i vlagalishteto (s prinos na 4 sluchaia i literaturen obzor).