title: A role for a new vascular enzyme in the metabolism of xenobiotic amines.
abstract: Although it has long been thought that environmental toxins may play an underlying role in vascular diseases such as atherosclerosis, this concept is not supported by any clear-cut experimental evidence of toxic metabolism by cardiovascular enzymes. In this study, we demonstrate that allylamine, a selective cardiovascular toxin in vivo, is actively metabolized in vitro by a purified vascular enzyme (semicarbazide-sensitive amine oxidase), which has been localized recently to vascular smooth muscle cells. Oxidative deamination of allylamine to a highly toxic aldehyde, acrolein, was blocked through enzyme inhibition by semicarbazide-sensitive amine oxidase suggests that this vascular enzyme's physiological role may include metabolism of exogenous amines.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston 77550.
authors.forename: P J
authors.initials: PJ
authors.lastname: Boor
authors.forename: R M
authors.initials: RM
authors.lastname: Hysmith
authors.forename: R
authors.initials: R
authors.lastname: Sanduja
mesh_terms: D000171:Acrolein / Q000378:metabolism; D000499:Allylamine / Q000378:metabolism; D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D000588:Amines / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003641:Deamination; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D013552:Swine; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D000588:Amines; D015262:Xenobiotics; D000499:Allylamine; D000171:Acrolein; D006631:Amine Oxidase (Copper-Containing)