Oncogenes and anti-oncogenes.
The study of oncogenes offers insights into many steps in signal transduction. Rapid progress is possible because of the combination of biochemistry and genetics--unique in vertebrate cell biology--the availability of specific clones and antibodies, sequence information, dominant mutants, and biochemical assays of function. The wealth of detail on oncogenes and proto-oncogenes continues to increase dramatically. Hopefully, in the next year or two some of the gaps will be filled in and all the steps along at least one pathway from the cell membrane to the nucleus will be understood.
Cooper
J A
JA
Fred Hutchinson Cancer Research Center, Seattle, Washington.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000502:physiology; D020690:GTPase-Activating Proteins; D006801:Humans; D008540:Meiosis / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology; D015689:Oncogene Protein p21(ras) / Q000502:physiology; D009857:Oncogenes / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011506:Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D015689:Oncogene Protein p21(ras)