Evaluation of the effects of gallopamil in patients with effort angina by transesophageal atrial pacing two-dimensional echocardiography.
Transesophageal atrial pacing (TAP) 2D echocardiography was performed after placebo (P) and gallopamil (G) (0.03 mg/kg iv) in 12 patients with stable, reproducible, effort angina. If compared to P study, during G the following changes were observed: 3 out of the 12 patients did not experience angina, time to ST-1mm increased from 5.3 +/- 1.3 to 6.6 +/- 1.6 min (p less than 0.05), wall motion score was improved both at 130 b/min (15.3 +/- 4.1 drug P, 17 +/- 4.8 drug G, p less than 0.01) and at 150 b/min (10.9 +/- 5.7 drug P, 12.8 +/- 6.3 drug G, p = 0.07). In conclusion, gallopamil has a beneficial effect on atrial pacing induced ischemia: it increases pacing time to ischemic threshold and reduces during ischemia the extent of dysfunctional myocardium.
Iliceto
S
S
Division of Cardiology, University of Bari, Italy.
Caiati
C
C
Piccinni
G
G
Tota
F
F
De Martino
G
G
Marangelli
V
V
Rizzon
P
P
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002304:Cardiac Pacing, Artificial; D004452:Echocardiography; D005260:Female; D005711:Gallopamil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture
D005711:Gallopamil