Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.
T cell receptor signaling has been implicated in an intrathymic process of cell selection in which potentially harmful autoreactive precursors are deleted before they emigrate to the periphery. Recent work has shown that immature thymocytes undergo apoptosis, or programmed cell death, upon stimulation via the T cell antigen receptor, and it has been suggested that this mechanism may mediate deletion of the self-reactive clones during T cell development. Here we report that the accessory cell-derived T cell growth hormone interleukin-1 prevents T cell receptor-mediated thymocyte apoptosis by a mechanism that appears to involve protein kinase C activation. This effect may be relevant to the positive signaling that spares the appropriate precursors during the generation of functional T lymphocytes.
McConkey
D J
DJ
Department of Toxicology, Karolinska Institutet, Stockholm, Sweden.
Hartzell
P
P
Chow
S C
SC
Orrenius
S
S
Jondal
M
M
D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000187:drug effects*; D004075:Diglycerides / Q000378:metabolism; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000494:pharmacology*; D011948:Receptors, Antigen, T-Cell / Q000187:drug effects / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D004075:Diglycerides; D007375:Interleukin-1; D011948:Receptors, Antigen, T-Cell; D000001:Calcimycin; D004247:DNA; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium