title: [Antianaphylactic components of Asarum forbsii Maxin].
abstract: From the ethyl acetate extract of Asarum forbesii Maxin, four new constituents, asarumin A(I), B(II), C(III) and D(IV), were isolated along with elemicin (V), trans-asarone(VI) and linoleic acid(VII). The structures of the new compounds were elucidated as methyl 3 S-benzoyloxy-2 S-hydroxy-2-isopropylbutyrate for I, methyl 2 R-benzoyloxyisopentanoate for II, methyl 2 R-trans-cinnamoyloxyisopentanoate for III and methyl 2 R-piperonyloyloxyisopentanoate for IV. Compounds I, II, III and VII showed weak inhibition of PCA in rats, but the other compounds were inactive.
authors.affiliation: Department of Antiasthmatic Drugs, Zhejiang Medical University.
authors.forename: R L
authors.initials: RL
authors.lastname: Bian
authors.forename: Q M
authors.initials: QM
authors.lastname: Xie
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Asai
authors.forename: T
authors.initials: T
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Kishi
mesh_terms: D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D014631:Valerates / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001565:Benzoates; D002087:Butyrates; D002934:Cinnamates; D004365:Drugs, Chinese Herbal; D008041:Linoleic Acids; D014631:Valerates; C069458:asarumin A; C069459:asarumin B; C069460:asarumin C; D019787:Linoleic Acid