Is vitamin D necessary for skeletal integrity in the elderly?
Serum 1.25 dihydroxyvitamin D concentrations were reduced in elderly patients with femoral neck fractures, irrespective of the presence of osteomalacia. This reduction was not attributable to a decrease in vitamin D binding protein. The low rate of bone turnover in these elderly patients might reduce the requirement for vitamin D and protect against the development of osteomalacia. Serum vitamin D metabolite concentration cannot be used as a screening test for osteomalacia in these patients.
Thompson
S P
SP
Department of Biochemistry, University Hospital, Queen's Medical Centre, Nottingham, England.
Wilton
T J
TJ
Hosking
D J
DJ
White
D A
DA
Pawley
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002117:Calcitriol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005265:Femoral Neck Fractures / Q000097:blood / Q000188:drug therapy; D006801:Humans; D005779:Immunodiffusion; D008875:Middle Aged; D010018:Osteomalacia / Q000097:blood / Q000188:drug therapy; D011485:Protein Binding; D064030:S100 Calcium Binding Protein G / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy
D064030:S100 Calcium Binding Protein G; D014807:Vitamin D; D002117:Calcitriol