Comparison of prostacyclin production of human gastroepiploic artery and saphenous vein.
The prostacyclin production of the gastroepiploic artery (GEA) and saphenous vein (SV) were studied in 5 patients undergoing coronary artery revascularization. The GEA produced 90.0 +/- 11.9, 132.4 +/- 13.7, and 191.1 +/- 21.8 pg/mg tissue (mean +/- standard error of the mean) of 6-keto-prostaglandin F1 alpha (prostacyclin metabolite) after 2.5, 5.0, and 10.0 minutes, respectively, of incubation in Krebs-Henseleit buffer at 37 degrees C. The SV produced 39.8 +/- 7.0, 66.7 +/- 9.1, and 123.6 +/- 15.1 pg/mg tissue of 6-keto prostaglandin F1 alpha after 2.5, 5.0, and 10.0 minutes, respectively, of incubation. The GEA produced significantly more 6-keto-prostaglandin F1 alpha than SV at all three sampling times up to ten minutes of incubation (p less than 0.01). Prostacyclin is a potent vasodilator and an inhibitor of platelet aggregation. Prostacyclin production by the internal mammary artery was reported to be much higher than that of SV, and the patency rate of internal mammary artery grafts is reported to be better than that of SV grafts in coronary artery revascularization. Therefore, our results suggest that the patency rate of GEA grafts may be better than that of SV grafts in coronary artery revascularization. The GEA is a promising and excellent graft from the biochemical point of view.
Oku
T
T
Department of Thoracic Surgery, Osaka Medical College, Japan.
Yamane
S
S
Suma
H
H
Satoh
H
H
Koike
R
R
Sawada
Y
Y
Takeuchi
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D001158:Arteries / Q000378:metabolism*; D003331:Coronary Vessels / Q000601:surgery; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D009852:Omentum / Q000098:blood supply; D012501:Saphenous Vein / Q000378:metabolism*; D013270:Stomach / Q000098:blood supply; D014654:Vascular Patency
D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol