[Early prognostic significance of hepatitis B surface antigen specific circulating immune complexes in acute type B viral hepatitis].
A total of 120 patients with acute viral hepatitis B was investigated for the presence of circulating immune complexes, HBsAg-specific immune complexes, and the behavior of some other immune parameters (immunoglobulins, rosette inhibitory factor RIF, histamine induced inhibition of spontaneous rosette forming lymphocytes). Pathologically elevated levels of circulating immune complexes were seen in 89 per cent of patients, often related to extrahepatic signs in the prodromal phase. In 95.7 per cent of them, HBsAg-containing complexes were found. There were no differences in the behavior of immune complexes between patients with recovery and patients developing chronic hepatitis B. On the contrary, the levels of RIF and differences in the inhibitory effect of histamine on rosette forming test of patient's lymphocytes did allow to distinguish patients with recovery from patients with development of chronic hepatitis B early in the course.
Markus
R
R
Infektionsklinik, Städtischen Krankenhauses Berlin-Prenzlauer Berg.
D000936:Antigen-Antibody Complex / Q000032:analysis* / Q000276:immunology; D006509:Hepatitis B / Q000175:diagnosis* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008077:Lipoproteins, LDL / Q000032:analysis; D011379:Prognosis; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens; D008077:Lipoproteins, LDL; C022060:rosette-inhibiting factor
Untersuchungen zur frühprognostischen Bedeutung hepatitis-B-surface-antigen-spezifischer zirkulierender Immunkomplexe bei akuten Virushepatitiden Typ B.