[Use of the "Sartorius" cutaneous absorption simulator for transdermal pharmaceutical forms of NSAIDs].
We report the results of the in vitro-release of the active ingredients (flurbiprofen and ibuprofen) from dermal form obtained by the Sartorius Absorption simulator SM16750. The results show that the choice of the excipients is basic. Using NSAID, the aqueous gel can be considered the suitable formulation to obtained a good in vitro-release. The quantities of the active ingredients released during the time are plotted in diagrams.
Valenti
M
M
Gruppo Formenti, Laboratori di Ricerca, Origgio (Va) Italy.
Bandi
G L
GL
Passarotti
C
C
Fossati
A
A
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D005480:Flurbiprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005480:Flurbiprofen; D007052:Ibuprofen
Utilizzazione del simulatore di assorbimento cutaneo "Sartorius" per la messa a punto di forme farmaceutiche transdermiche contenenti FANS.