Synthesis and preliminary pharmacological assessment of novel gamma-hydroxybutyric acid derivatives.
Synthesis and properties of new N-substituted amides of alpha-(1,1-ethylenedioxy)-ethyl-gamma-hydroxybutyric acid are described. The compounds were obtained by aminolysis of 3-(1,1-ethylenedioxy)-ethyltetra-hydrofuran-2-on with primary alkylarylamines. Preliminary pharmacological assessment revealed that the compounds exert weaker influence on the central nervous system than the reference gamma-hydroxybutyric acid. Three of the novel compounds offered some protection against pentetrazole-induced tonic seizures in mice.
Malec
D
D
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Modzelewski
J
J
Malawska
B
B
Gorczyca
M
M
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000031:analogs & derivatives*
D000700:Analgesics; D012978:Sodium Oxybate; D010433:Pentylenetetrazole