title: Cerebral blood flow velocity recordings and the prediction of intracranial haemorrhage and ischaemia.
abstract: Doppler ultrasound was used to study prospectively cerebral and cardiovascular hemodynamics in a cohort of 120 preterm infants to see whether it was possible to predict infants at increased risk of developing cerebral pathology. The infants were divided into four outcome groups: Group I (n = 65, median gestation = 30 weeks) did not develop periventricular haemorrhage (PVH) nor periventricular leukomalacia (PVL) Group II (n = 43, median gestation = 28 weeks) developed PVH as the first or only cerebral lesion Group III (n = 7, median gestation = 29 weeks) developed PVL as the first or only cerebral lesion Group IV (n = 5, median gestation = 28 weeks) developed PVH and PVL simultaneously. Cerebral blood flow velocity (CBFV) and aorta blood flow velocity (ABFV) recordings made before the onset of PVH or PVL were compared between the four groups on each postnatal day but it was not possible to demonstrate a statistically significant difference between these variables in the four outcome groups. We conclude, therefore, that it is not possible to identify the infants who will go on to develop haemorrhage or ischaemic lesions on the basis of Doppler cerebral haemodynamic studies.
authors.affiliation: Department of Child Health, Leicester University Medical School, England.
authors.forename: D B
authors.initials: DB
authors.lastname: Shortland
authors.forename: M
authors.initials: M
authors.lastname: Levene
authors.forename: N
authors.initials: N
authors.lastname: Archer
authors.forename: D
authors.initials: D
authors.lastname: Shaw
authors.forename: D
authors.initials: D
authors.lastname: Evans
mesh_terms: D001011:Aorta / Q000502:physiology; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology; D004453:Echoencephalography; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D007969:Leukomalacia, Periventricular / Q000503:physiopathology; D015999:Multivariate Analysis; D011446:Prospective Studies