title: Neuropeptide Y (NPY)-containing nerves in mammalian ureter.
abstract: The distribution of neuropeptide Y in the ureter of the rat, rabbit, and man has been determined by radioimmunoassay and chromatographic analysis of the tissue extract. The localization of neuropeptide Y-immunoreactivity has been identified by immunocytochemistry. A regional distribution of neuropeptide Y was found; highest concentrations being present in the ureterovesical junction. Throughout the ureter, neuropeptide Y-immunoreactive nerve fibers were identified to surround the blood vessels and a few plexuses of neuropeptide Y-containing nerves were present within the muscle layers. Neuropeptide Y was not present within ganglion cells. Treatment of rats with 6-hydroxydopamine resulted in a significant reduction of neuropeptide Y concentrations in the upper, middle, and lower thirds of the ureter. This depletion in extractable neuropeptide Y was associated with morphologic changes typical of axonal degeneration of the neuropeptide Y-containing nerve fibers.
authors.affiliation: Department of Medicine, Royal Postgraduate Medical School, London, England.
authors.forename: J M
authors.initials: JM
authors.lastname: Allen
authors.forename: J
authors.initials: J
authors.lastname: Rodrigo
authors.forename: D J
authors.initials: DJ
authors.lastname: Kerle
authors.forename: K
authors.initials: K
authors.lastname: Darcy
authors.forename: G
authors.initials: G
authors.lastname: Williams
authors.forename: J M
authors.initials: JM
authors.lastname: Polak
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism; D009478:Neuropeptide Y / Q000032:analysis*; D016627:Oxidopamine; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000033:anatomy & histology / Q000378:metabolism; D014513:Ureter / Q000294:innervation* / Q000378:metabolism
chemical_list: D006892:Hydroxydopamines; D009478:Neuropeptide Y; D016627:Oxidopamine