[The biological properties of monoclonal antibodies to the cytolysin of Legionella pneumophila].
The study of the biological properties of monoclonal antibodies (McAb) to L. pneumophila cytolysin has been carried out. These McAb have been shown to possess no capacity for the in vitro neutralization of cytolysin and the protection of guinea pigs from aerosol infection with L. pneumophila. Still the protective effect of the McAb under study has been observed in experiments with the intraperitoneal infection of guinea pigs, which is indicative of the possibility, in principle, of involving humoral immunity into the protection of the body from Legionella infection.
Spitsyn
S V
SV
Barkhatova
O I
OI
Drobyshevskaia
E I
EI
Belyĭ
Iu F
IuF
Petrosov
V V
VV
Tartakovskiĭ
I S
IS
Nesterenko
V G
VG
D000281:Administration, Intranasal; D000336:Aerosols; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D003603:Cytotoxins / Q000276:immunology*; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D007875:Legionella / Q000276:immunology*; D007877:Legionnaires' Disease / Q000209:etiology / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C
D000336:Aerosols; D000911:Antibodies, Monoclonal; D003603:Cytotoxins
Issledovanie biologicheskikh svoĭstv monoklonal'nykh antitel k tsitolizinu Legionella pneumophila.