Chronic cholestasis, paucity of bile ducts, red cell aplasia, and the Stevens-Johnson syndrome. An ampicillin-associated case.
The unique case of severe chronic cholestasis with paucity of bile ducts accompanied by pure red cell aplasia and the Stevens-Johnson syndrome in a 35-year-old woman after ampicillin ingestion is presented. The patient improved gradually and is asymptomatic 4 years later. Sequential histological and clinical follow-up substantiate the course of her disease.
Cavanzo
F J
FJ
Department of Pathology, Fundación Santa Fé de Bogotá, Colombia.
Garcia
C F
CF
Botero
R C
RC
D000328:Adult; D000667:Ampicillin / Q000009:adverse effects*; D001649:Bile Duct Diseases / Q000139:chemically induced*; D002779:Cholestasis / Q000139:chemically induced*; D002908:Chronic Disease; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D000667:Ampicillin