Enhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate.
The effect of phorbol 12,13-dibutyrate on calcium ionophore (A23187)-induced release of vasoactive intestinal polypeptide from enteric nerves was examined. A23187 caused release of vasoactive intestinal polypeptide dose dependently and phorbol 12,13-dibutyrate (100 nM) markedly shifted the dose-response curve of A23187 to the left. The significance of these findings will be discussed in relation to the mechanism of release of vasoactive intestinal polypeptide from enteric nerves.
Belai
A
A
Department of Anatomy and Developmental Biology, University College London, U.K.
Dale
M M
MM
Burnstock
G
G
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide; D015240:Phorbol 12,13-Dibutyrate; D000001:Calcimycin; D011493:Protein Kinase C