Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid-liquid extraction.
Benzalkonium chloride was assayed by on-line extraction of the benzalkonium ion with picrate to chloroform. The absorbance of picrate was measured. The extractions were performed with a home-made flow injection extraction unit. Calibration curves (1.5-180 x 10(-4)% w/v) were straight lines (r = 0.9993) and the relative standard deviation of a series of injections was less than or equal to 2%. Pharmaceutical benzalkonium preparations, containing xylometazoline, timolol, phenylephrine or carbachol could also be assayed. The method was compared with a modified HPLC assay.
Halvax
J J
JJ
Utrecht University, Department of Pharmaceutical Analysis, The Netherlands.
Wiese
G
G
Arp
J A
JA
Vermeer
J M
JM
van Bennekom
W P
WP
Bult
A
A
D001548:Benzalkonium Compounds / Q000032:analysis*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid
D001548:Benzalkonium Compounds