Increased activity of circulating polymorphonuclear leukocytes in acute myocardial infarction.
Acute myocardial infarction results in an increased sensitivity of circulating polymorphonuclear leukocytes to ex vivo aggregation. This increase was prevented by pretreatment of leukocytes with BW755, but not with aspirin, suggesting that the activation of blood leukocytes in infarction is due to a stimulation of cellular lipoxygenase.
Radomski
M
M
Medical Research Centre, Polish Academy of Sciences, Warsaw.
Herbaczyńska-Cedro
K
K
Ceremuzyński
L
L
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine / Q000494:pharmacology; D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D002449:Cell Aggregation / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D001241:Aspirin