title: Etoposide protects mice from radiation-induced bone marrow death.
abstract: Etoposide is known to inhibit the activity of topoisomerase II, and to possess radiosensitizing effects. In this paper we show that pretreatment of mice with etoposide one day before whole-body irradiation had a protective effect against radiation-induced bone marrow death. The LD50/30 of mice given radiation alone was 8.26 Gy while that of mice given etoposide one day before whole-body irradiation was 10.35 Gy. The number of endogenous colony-forming units surviving in whole body-irradiated mice was significantly increased by pretreatment with etoposide.
authors.affiliation: Division of Clinical Research, National Institute of Radiological Sciences, Chiba.
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: S
authors.initials: S
authors.lastname: Koike
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D005047:Etoposide / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011835:Radiation Protection; D014916:Whole-Body Irradiation
chemical_list: D005047:Etoposide