[Substantiation of the use of pepsidil in secretory insufficiency of the digestive glands caused by antitubercular drugs].
The experiments on rats were undertaken to study the action of pepsidil to make up for the biosynthesis deficiency of digestive enzymes in the stomach and pancreas caused by antituberculous drugs (methazide + PAS, isoniazid + PAS, isoniazid + rifampicin + ethambutol). It was proved that pepsidil reduced an inhibiting action of antituberculous drugs on the activity of gastroenteric tract proteinases. The given condition should be taken into account when antituberculous treatment is conducted.
Storozhuk
P G
PG
Kolesnikov
V V
VV
Malan'ina
N S
NS
Popova
Iu A
IuA
D000818:Animals; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000172:deficiency*; D004353:Drug Evaluation, Preclinical; D010450:Endopeptidases / Q000096:biosynthesis / Q000378:metabolism; D004790:Enzyme Induction; D004791:Enzyme Inhibitors; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D010434:Pepsin A / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000627:therapeutic use*; D051381:Rats; D014357:Trypsin / Q000172:deficiency*; D014361:Trypsin Inhibitors; D014376:Tuberculosis / Q000188:drug therapy* / Q000201:enzymology
D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D014361:Trypsin Inhibitors; D010450:Endopeptidases; D002918:Chymotrypsin; D014357:Trypsin; D010434:Pepsin A
Obosnovanie ispol'zovaniia pepsidila pri sekretornoĭ nedostatochnosti pishchevaritel'nykh zhelez, vyzvannoĭ protivotuberkuleznymi preparatami.