A case of alveolar rhabdomyosarcoma with a chromosomal translocation, t(2;13)(q37;q14).
We report on an alveolar rhabdomyosarcoma occurring in a 17-year-old girl. Histologically, the tumour exhibited a proliferation of small, round cells and formed alveolar structures. Immunohistochemical studies of the tumour cells showed desmin and creatine kinase MM positivity. In electron-microscopic studies, the tumour cells showed an abundance of glycogen granules, and myofilaments were recognized in the cytoplasm. Chromosome analysis revealed a translocation, t(2;13)(q37;q14), which is though to be common in this subtype of rhabdomyosarcoma. Conventional ultrastructural and immunohistochemical investigations and chromosome analysis thus appear to be a highly promising combination of methods for improved pathological diagnosis of alveolar rhabdomyosarcoma.
Nojima
T
T
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Abe
S
S
Yamaguchi
H
H
Matsuno
T
T
Inoue
K
K
D000293:Adolescent; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic