Disposition kinetics, renal clearance and excretion of ampicillin after oral administration in goats.
Disposition kinetics, renal clearance and urinary excretion of ampicillin were determined after oral administration of 10 mg/kg in 8 goats. Peak plasma concentration 1.86 +/- 0.14 mumol/l was attained at 117 +/- 11 min after oral administration. Half-time of absorption was 28.7 +/- 5.8 minutes and that of elimination was 135 +/- 15 minutes. Total area under plasma concentration versus time curve was 9.16 +/- 0.97 mumol.h/l. Total body clearance of ampicillin was 52.1 +/- 4.2 and renal clearance was 0.07 +/- 0.008 ml/min.kg. The renal handling of ampicillin involved glomerular filtration and back diffusion.
Nawaz
M
M
Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Tabassum
R
R
Iqbal
T
T
Perveen
Z
Z
D000042:Absorption; D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D003404:Creatinine / Q000652:urine; D005260:Female; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D007668:Kidney / Q000378:metabolism*
D000667:Ampicillin; D003404:Creatinine