[The immunomodulating properties of a macro glycopeptide isolated from serum. II. The activation of macrophages and polymorphonuclear cells].
The stimulating properties of three fractions of a glucomacropeptide consisting of different carbohydrate and peptide components were studied. The phagocytic activity of polymorphonuclears was increased on the 24th hour and of macrophages on the 3rd day after application of the preparations to mice. In vitro fraction 3 stimulates the lysozyme activity and the synthesis of proteins and Clq of the macrophages complement. These properties of the cells are collaborated by the established ultrastructural changes. The different composition of the fractions determines their immunostimulating effect.
Neĭchev
Kh
Kh
Ivanovska
N
N
Shirova
L
L
Slavcheva
E
E
Stoianova
P
P
Georgiev
D
D
Abrashev
I
I
Velcheva
P
P
Ianchev
I
I
D000276:Adjuvants, Immunologic; D000818:Animals; D015922:Complement C1q / Q000187:drug effects / Q000276:immunology; D006020:Glycopeptides / Q000302:isolation & purification / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D046911:Macromolecular Substances; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D009113:Muramidase / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D046911:Macromolecular Substances; D010446:Peptide Fragments; D015922:Complement C1q; D009113:Muramidase
Imunomodulirashti svoĭstva na gliukomakropeptid, izoliran ot surovatka. II. Aktivirane na makrofagi i polimorfonukleari.