Ethanol decreases choice accuracy in a radial maze delayed test.
1. The effect of acute ethanol on memory was studied in an eight-arm radial maze by interposing a 15-s or 1-h delay between the rat's fourth and fifth arm choices. 2. Ethanol (1.0 g/kg) was injected intraperitoneally 5 min prior to the first set of 4-arm choices, therefore being present since the acquisition of the trial-unique event. 3. The results showed 1) a decrease in choice accuracy only in the final 4 arm choices after the 1-h delay, and 2) that errors consisted of re-entries into arms chosen before the delay was imposed. The data further support the contention that ethanol impairs retention of working memory.
Oliveira
M G
MG
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Kireeff
W
W
Hashizume
L K
LK
Bueno
O F
OF
Masur
J
J
D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012153:Retention, Psychology / Q000187:drug effects; D013037:Spatial Behavior; D013647:Task Performance and Analysis
D000431:Ethanol