Hyperbaric oxygen- and ethanol-induced infiltration of rat hepatic triglycerides and the protective action of coenzyme A.
The ethanol-induced increased synthesis of fatty acids in the liver is enhanced by hyperbaric oxygen exposure. Both lipid peroxidation and glutathione depletion are involved in these hepatic alterations. Coenzyme A can intervene in these mechanisms. The administration of CoA prevents hepatic lipid infiltration and the glutathione reduction induced in the rats by ethanol and hyperbaric oxygen exposure.
Bertelli
A
A
Department of Pharmacology, Chemotherapy and Medical Toxicology, Milan University, Italy.
Cerrati
A
A
Giovannini
L
L
Mian
M
M
Spaggiari
P
P
Bertelli
A A
AA
D000818:Animals; D003065:Coenzyme A / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008104:Liver Cirrhosis, Alcoholic / Q000517:prevention & control; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D014280:Triglycerides; D000431:Ethanol; D003065:Coenzyme A