Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium.
The effects of sodium nitrite (NaNO2) and catechol or 3-methoxycatechol in combination were examined in male F344 rats. Animals were treated with 0.3% NaNO2 in the drinking water and 0.8% catechol or 2% 3-methoxycatechol in powdered diet for 24 weeks. While catechol or 3-methoxycatechol alone induced low incidences of mild or moderate hyperplasia, simultaneous administration of NaNO2 markedly enhanced the degree of hyperplasia and papilloma formation. In contrast, induction of submucosal hyperplasia and adenomas in the glandular epithelium was reduced. Thus, the results indicate that NaNO2 can modulate the metabolism of antioxidants, so that, possibly via production of new active moieties, targeting of forestomach epithelium is enhanced.
Hirose
M
M
First Department of Pathology, Nagoya City University Medical School.
Fukushima
S
S
Hasegawa
R
R
Kato
T
T
Tanaka
H
H
Ito
N
N
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D002396:Catechols / Q000008:administration & dosage*; D004357:Drug Synergism; D004848:Epithelium / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D006965:Hyperplasia; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012977:Sodium Nitrite / Q000008:administration & dosage*; D013270:Stomach / Q000033:anatomy & histology / Q000187:drug effects* / Q000473:pathology; D013272:Stomach Diseases / Q000139:chemically induced*; D013274:Stomach Neoplasms / Q000139:chemically induced
D000975:Antioxidants; D002396:Catechols; C066344:3-methoxycatechol; C034221:catechol; D012977:Sodium Nitrite