Bone marrow findings in HIV infection: a pathological study.
The histopathologic changes of bone marrow during infection with the human immunodeficiency virus type 1 (HIV-1) are described. Bone marrow biopsies from 73 patients at different stages of HIV-1 infection were studied. Indications for biopsy included peripheral blood abnormalities, suspicion of lymphoma, or search for specific pathogens. Common histopathological features, suggestive of HIV-1 infection but nonpathognomonic were hypercellularity (67%), myelodysplasia (86.1%), plasmacytosis (98.6%), lymphocytic infiltration (31.1%) and histiocytic infiltration with or without granulomata (13.7%). Increases in reticulin fibers (54.7%), and stainable iron deposits, vascular congestion and serous atrophy of fat were frequent features. Opportunistic infections and neoplastic complications were detected in 7 cases: pathogens were demonstrated in 4 cases (Mycobacterium avium intracellulare (MAI), Cryptococcus neoformans, Toxoplasma gondii and Leishmania) and lymphoma in 3 cases (1 Burkitt lymphoma and 2 Hodgkin's disease). Bone marrow hypoplasia is usually a terminal event in AIDS and may be iatrogenic.
Marche
C
C
Tabbara
W
W
Michon
C
C
Clair
B
B
Bricaire
F
F
Matthiessen
L
L
D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000150:complications / Q000175:diagnosis; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006689:Hodgkin Disease / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006965:Hyperplasia; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis; D012307:Risk Factors