Genetic analysis of the Shaker gene complex of Drosophila melanogaster.
The Shaker complex (ShC) spans over 350 kb in the 16F region of the X chromosome. It can be dissected by means of aneuploids into three main sections: the maternal effect (ME), the viable (V) and the haplolethal (HL) regions. The mutational analysis of ShC shows a high density of antimorphic mutations among 12 lethal complementation groups in addition to 14 viable alleles. The complex is the structural locus of a family of potassium channels as well as a number of functions relevant to the biology of the nervous system. The constituents of ShC seem to be linked by functional relationships in view of the similarity of the phenotypes, antimorphic nature of their mutations and the behavior in transheterozygotes. We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex.
Ferrús
A
A
Instituto Cajal, CSIC, Madrid, Spain.
Llamazares
S
S
de la Pompa
J L
JL
Tanouye
M A
MA
Pongs
O
O
D000200:Action Potentials; D000483:Alleles; D000782:Aneuploidy; D000818:Animals; D015139:Blotting, Southern; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D006579:Heterozygote; D008297:Male; D009030:Mosaicism; D005810:Multigene Family; D009154:Mutation; D010641:Phenotype; D015221:Potassium Channels / Q000378:metabolism*
D015221:Potassium Channels