Indomethacin affects the development of tolerance to ethanol-induced diuresis.
The present study analyzes the effect of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were treated with ethanol (2 g kg-1 day-1, ip) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treated simultaneously with ethanol plus indomethacin (5 mg/kg, ip, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indomethacin prevented the development of tolerance to the diuretic effect of ethanol but had no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol.
Morato
G S
GS
Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
Rosas
A M
AM
Bittencourt
S C
SC
Chacon
A M
AM
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004361:Drug Tolerance; D000431:Ethanol / Q000037:antagonists & inhibitors*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D000431:Ethanol; D007213:Indomethacin