Effect of prolonged intravenous infusion of gludopa in humans and a preliminary study of its oral bioavailability.
Intravenous infusion of gamma-glutamyl-L-dopa (25 micrograms/kg/min) for 10 h in normal humans caused a natriuresis of 46.5 mmol of sodium without an increase in plasma renin activity and was associated with small but significant falls in blood pressure. In a second study the oral bioavailability of gludopa was estimated in normal subjects and found to be low (less than 2%). The increase in urine dopamine excretion and the natriuretic effect of gludopa were much larger after intravenous infusion than oral dosing.
Freestone
S
S
University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, Scotland.
Ellis
R
R
MacDonald
T M
TM
Lee
M R
MR
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D004298:Dopamine / Q000652:urine; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013997:Time Factors; D014556:Urine / Q000032:analysis
C017342:gamma-glutamyl DOPA; D004295:Dihydroxyphenylalanine; D004298:Dopamine