A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG).
The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain starts with an "extra sequence". The amino acid sequence of this segment is Arg-Gln-Ser-Asp-Asp-Pro-Val-Leu-Arg-Gly-Thr-Thr-Val-Pro-Val-Thr-Glu and its reinitiation point is located at Val223 (Gal numbering), at the beginning of C mu 2. This sequence has no homology with any other protein included in the present databases.
Mihaesco
C
C
Laboratoire d'Immunochimie et d'Immunopathologie, U.108 INSERM, Hôpital Saint-Louis, Paris, France.
Ferrara
P
P
Guillemot
J C
JC
Congy
N
N
Gendron
M C
MC
Roy
J P
JP
Sizaret
P Y
PY
Mihaesco
E
E
D000595:Amino Acid Sequence; D006362:Heavy Chain Disease / Q000235:genetics*; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007075:Immunoglobulin M / Q000235:genetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009154:Mutation
D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M