Insulin stimulates postnatal development of renal tubular transport of p-aminohippurate.
The influence of repeated administration of insulin on renal tubular transport of PAH was investigated. There was a stimulating effect in young rats with an immature kidney function. The distinctly higher degree of accumulation in renal cortical slices is in accordance with the enhanced PAH excretion in 10- and 20-day-old animals.
Penzold
K
K
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena.
Bräunlich
H
H
D000818:Animals; D001692:Biological Transport; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D007684:Kidney Tubules / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D007328:Insulin; D010130:p-Aminohippuric Acid