title: Luteal-phase defect induced by deprivation of FSH at a specific period of the follicular phase prevents pregnancy in the bonnet monkey (Macaca radiata).
abstract: Female bonnet monkeys were injected i.v. with 25 microliters antiserum to FSH on Days 5, 6 or 7 of the cycle: the length of the luteal phase was shortened but there was no alteration in cycle length. Proven fertile females (N = 6) were caged throughout the period of the experiment (6 cycles) with proven fertile males and treated with 25 microliters FSH antiserum on Day 7 of each of 3 successive cycles. Out of 18 cycle exposures during the treatment phase, 17 were ovulatory, but no pregnancies occurred. In the post-treatment phase, 5 monkeys became pregnant within 3 cycle exposures. These results show that it is possible to render female monkeys infertile by creating luteal insufficiency and this can be achieved repeatedly in a reproducible manner by depriving the cyclic females of FSH support on Day 7 of consecutive cycles.
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore.
authors.forename: N
authors.initials: N
authors.lastname: Ravindranath
authors.forename: N R
authors.initials: NR
authors.lastname: Moudgal
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000276:immunology / Q000502:physiology*; D005498:Follicular Phase / Q000502:physiology*; D007106:Immune Sera / Q000276:immunology; D008255:Macaca radiata; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*
chemical_list: D007106:Immune Sera; D005640:Follicle Stimulating Hormone