Sodium D-lactate infusion of panic disorder patients.
Nineteen patients with panic disorder received sodium D,L-lactate (racemic) and pure sodium D-lactate infusions in a pilot study. Sodium D-lactate, which is less metabolically active than L-lactate, produced panic attacks in half the patients. D-Lactate also produced hypocapnia and alkalosis, indicating hyperventilation. These findings suggest that metabolism of lactate is not necessary for the induction of panic in susceptible patients. D-Lactate appears similar to other agents that cause panic in its capacity to stimulate respiration in the preliminary study.
Gorman
J M
JM
Biological Studies Unit, New York State Psychiatric Institute, NY.
Goetz
R R
RR
Dillon
D
D
Liebowitz
M R
MR
Fyer
A J
AJ
Davies
S
S
Klein
D F
DF
D000328:Adult; D000379:Agoraphobia / Q000503:physiopathology; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005239:Fear; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006985:Hyperventilation / Q000139:chemically induced / Q000503:physiopathology; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D019344:Lactic Acid; D008297:Male; D010200:Panic; D010698:Phobic Disorders / Q000139:chemically induced / Q000503:physiopathology*; D010710:Phosphates / Q000097:blood; D010865:Pilot Projects; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013237:Stereoisomerism
D001639:Bicarbonates; D007773:Lactates; D010710:Phosphates; D011773:Pyruvates; D002245:Carbon Dioxide; D019344:Lactic Acid; D019289:Pyruvic Acid; D002118:Calcium