Formulation and in vitro-in vivo evaluation of sustained-release lithium carbonate tablets.
The release of lithium carbonate incorporated into polymethylmethacrylate, polyvinyl chloride, hydrogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability.
Ciftçi
K
K
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey.
Capan
Y
Y
Oztürk
O
O
Hincal
A A
AA
D000328:Adult; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000032:analysis; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged
D003692:Delayed-Action Preparations; D005079:Excipients; D016651:Lithium Carbonate; D008094:Lithium