The effect of Chinese tea on the occurrence of esophageal tumors induced by N-nitrosomethylbenzylamine formed in vivo.
Five groups of rats (22 per group) were intubated with precursors of N-nitrosomethylbenzylamine (NMBzA), i.e., methylbenzylamine (1 mmol/kg body wt) and sodium nitrite (0.5 mmol/kg body wt), and with five different varieties of Chinese tea twice a week. One positive control group was intubated with precursors of NMBzA without tea, and a negative control group was given tap water and sodium nitrite only. After 12 weeks of treatment, significantly fewer lesions and papillomas in the esophageal mucosa were found in the tea-treated group than in the positive control group. The results confirmed the anticarcinogenic effects of Chinese tea in rats by blocking the in vivo formation of NMBzA.
Xu
Y
Y
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Chi
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H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010212:Papilloma / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013662:Tea
D002273:Carcinogens; D013662:Tea; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine