A syndrome of hyperandrogenism, insulin resistance, and acanthosis nigricans associated with polycystic ovary syndrome: clinical and laboratory features.
We describe an adolescent Japanese girl with acanthosis nigricans and irregular anovulatory menstruation following menarche. Serum LH levels were elevated, whereas serum FSH levels were within normal range. An exaggerated response to LHRH was observed. Further, serum androstenedione levels were markedly elevated. Ultrasonogram revealed bilateral polycystic changes of ovaries. She had a mild degree of insulin resistance. Insulin binding studies using erythrocytes demonstrated a decreased binding capacity of insulin. From the above findings, this patient presents the syndrome consisting of hyperandrogenism, insulin resistance, and acanthosis nigricans and also has clinical and biochemical features compatible with polycystic ovary syndrome.
Taketani
Y
Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Mizuno
M
M
D000052:Acanthosis Nigricans / Q000150:complications*; D000293:Adolescent; D000728:Androgens / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D000858:Anovulation / Q000150:complications; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007564:Japan; D008599:Menstruation Disturbances / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D013739:Testosterone / Q000097:blood
D000728:Androgens; D001786:Blood Glucose; D006065:Gonadotropins, Pituitary; D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D000735:Androstenedione