Growth hormone and somatomedin-C secretion in patients with polycystic ovarian disease. Their relationships with hyperinsulinism and hyperandrogenism.
Nineteen women with polycystic ovarian disease (PCO; 9 obese) and 15 normal ovulatory women (7 obese) were studied at their follicular phase. All patients had an oral glucose tolerance test (OGTT) before and after treatment with gonadotropin-releasing hormone (GnRH) agonist (Buserelin 400 micrograms/die s.c. for 8 weeks) to investigate the relationship between ovarian steroidogenesis and insulin and growth hormone (GH) and insulin-like growth factor (SmC) secretion. Luteinizing hormone, follicle-stimulating, estradiol, androstenedione, testosterone, dehydroepiandrosterone sulfate, cortisol, insulin, GH and SmC were measured basally at the time of OGTT. PCO patients showed higher androgen basal levels than control patients. All subjects showed a normal glycemic response to OGTT. The mean fasting level and area under the curve of plasma insulin were also significantly greater in PCO than in control patients (p less than 0.05), while GH and SmC plasma concentrations did not differ between the groups. Despite a considerable decrease in androgens and the similar levels in both PCO and control women, buserelin treatment did not determine any significant changes of insulin and GH-SmC secretion. GH and SmC did not correlate with ideal body weight (IBW), insulin or androgens, whereas insulin correlated with both testosterone and androstenedione levels (p less than 0.05) and with IBW (p less than 0.01); after the buserelin regimen only IBW remained related to plasma insulin (p less than 0.01). In conclusion results of this study confirm that hyperinsulinism is a characteristic picture of PCO and is related in an unclear way with hyperandrogenism and obesity.(ABSTRACT TRUNCATED AT 250 WORDS)
Lanzone
A
A
Department of Obstetrics and Gynecology, Università Cattolica S. Cuore, Rome, Italy.
Fulghesu
A M
AM
Pappalardo
S
S
Proto
C
C
Le Donne
M
M
Andreani
C L
CL
Muscatello
R
R
Caruso
A
A
Mancuso
S
S
D000328:Adult; D000735:Androstenedione / Q000097:blood; D002064:Buserelin / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D009765:Obesity / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D013002:Somatomedins / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D013002:Somatomedins; D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D013006:Growth Hormone; D005947:Glucose; D002064:Buserelin