[Treatment of nausea and vomiting induced by a 24-hour i.v. infusion of cisplatin].
Nine advanced gastric cancer patients were given 17 courses of cisplatin administrations by means of a 24-hour intravenous infusion at a dose of 100 mg/m2. For an anti-emetic, 40 mg of metoclopramide was administered 5 times at 6-hour intervals, along with a 500 mg hydrocortisone administration at the start of the cisplatin infusion. Despite this preventative treatment, nausea and/or vomiting occurred in over one-third of all the courses. Thus, to combat this nausea and/or vomiting, a combination of lorazepam (1.5 mg/day, divided into 3 p.o.), dexamethasone (20, 10 and 10 mg by i.v. at 3, 8, and 24 hours, respectively, after start of the cisplatin infusion), and a 60 mg intravenous administration of metoclopramide (5 times at 6-hour intervals) was given, and it was found that this new method (Method IV) prevented both nausea and vomiting.
Nagai
H
H
Dept. of Gastroenterology, National Nagoya Hospital.
Suga
S
S
Horiuchi
Y
Y
Kyokane
K
K
Miwa
Y
Y
Aoki
Y
Y
Yasue
K
K
Noro
T
T
Kamikawa
R
R
Ninomiya
E
E
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008140:Lorazepam / Q000008:administration & dosage; D008787:Metoclopramide / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D005641:Tegafur; D014498:Uracil; D003907:Dexamethasone; D008787:Metoclopramide; D008140:Lorazepam; D002945:Cisplatin; D006854:Hydrocortisone