title: Proximal gastric vagotomy with carbon dioxide laser: experimental studies in animals.
abstract: Proximal gastric vagotomy has been widely used as a surgical treatment for peptic ulcer disease. However, it is technically complex and time-consuming. Moreover, it may cause circulatory problems in the gastric mucosa. We have reported a new method of blood flow-preserving vagotomy with a carbon dioxide laser (CO2 laser vagotomy) developed in our laboratory. To assess its efficacy, we used cysteamine-induced ulcer and measured gastric mucosal blood flow in rats. The incidence of cysteamine-induced ulcer formation was reduced significantly in the group that underwent CO2 laser vagotomy compared with a group treated with proximal gastric vagotomy. Gastric mucosal blood flow was significantly better in the CO2 laser vagotomy group. Long-term follow-up of acid reduction was evaluated in dogs by the pentagastrin-stimulation test. Acid reduction in dogs was satisfactory during the 12 months of this study. CO2 laser vagotomy is a new, easy, time-saving, and circulatory-preserving technique for peptic ulcer disease.
authors.affiliation: First Surgical Department, National Defense Medical College, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kadota
authors.forename: K
authors.initials: K
authors.lastname: Mimura
authors.forename: S
authors.initials: S
authors.lastname: Kanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: S
authors.initials: S
authors.lastname: Tamakuma
mesh_terms: D000818:Animals; D002245:Carbon Dioxide; D003543:Cysteamine; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000601:surgery; D005753:Gastric Mucosa / Q000098:blood supply; D053685:Laser Therapy; D008297:Male; D010418:Pentagastrin; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D014629:Vagotomy, Proximal Gastric
chemical_list: D002245:Carbon Dioxide; D003543:Cysteamine; D010418:Pentagastrin