title: Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
abstract: N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.
authors.affiliation: Department of Pharmacy, Jadavpur University, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Bhowmick
authors.forename: R
authors.initials: R
authors.lastname: Bose
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: S P
authors.initials: SP
authors.lastname: Pal
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D002927:Cimetidine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; C063763:N-phthaloyl-4-aminobutyric acid; C017069:bicuculline methiodide; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D002927:Cimetidine; D015097:3-Mercaptopropionic Acid; D001640:Bicuculline