Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.
Landis
C A
CA
Department of Medicine, University of California, San Francisco 94143.
Harsh
G
G
Lyons
J
J
Davis
R L
RL
McCormick
F
F
Bourne
H R
HR
D000172:Acromegaly / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D000236:Adenoma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005947:Glucose; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006966:Hyperprolactinemia; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010911:Pituitary Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology
D013006:Growth Hormone; D019204:GTP-Binding Proteins; D005947:Glucose