title: Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function.
abstract: Regional cerebral blood flow (rCBF) was assessed in 40 chronic male schizophrenic patients (20 medicated, 20 unmedicated) and 31 matched normal controls with Dynamic Single-photon Emission Computed Tomography (D-SPECT). Blind analyses of normalized color-coded tomograms revealed significant bifrontal and bitemporal rCBF deficits in the patient group. Frontal flow deficits were most prominent in paranoid patients (n = 21) and right temporal deficits were most prominent in nonparanoid patients (n = 19). These relative regional declines were observed within the context of significantly elevated hemispheric blood flow in schizophrenics compared with controls. Reduced left frontal rCBF was associated with neuropsychological impairment on the Wisconsin Card Sorting Test and Luria-Nebraska Battery. Increased hemispheric CBF was correlated with the presence of positive schizophrenic symptoms. Medication status was unrelated to rCBF. These findings demonstrate that hypofrontality has important implications for cognitive function in some schizophrenic individuals.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas.
authors.forename: R G
authors.initials: RG
authors.lastname: Paulman
authors.forename: M D
authors.initials: MD
authors.lastname: Devous
authors.forename: R R
authors.initials: RR
authors.lastname: Gregory
authors.forename: J H
authors.initials: JH
authors.lastname: Herman
authors.forename: L
authors.initials: L
authors.lastname: Jennings
authors.forename: F J
authors.initials: FJ
authors.lastname: Bonte
authors.forename: H A
authors.initials: HA
authors.lastname: Nasrallah
authors.forename: J D
authors.initials: JD
authors.lastname: Raese
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology*; D005625:Frontal Lobe / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011581:Psychological Tests; D012039:Regional Blood Flow; D012559:Schizophrenia / Q000503:physiopathology*; D012563:Schizophrenia, Paranoid / Q000503:physiopathology*; D013702:Temporal Lobe / Q000098:blood supply*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002245:Carbon Dioxide