Two-year carbohydrate metabolism studies in women using a norethindrone or levonorgestrel triphasic oral contraceptive.
Carbohydrate metabolism was prospectively studied in 28 women using triphasic oral contraceptives (TOC) for two years. They were tested using a 100-gram oral glucose tolerance test with measurements of plasma glucose and insulin levels during the three-hour test. The women were randomly assigned to either a norethindrone-containing TOC or a levonorgestrel-containing TOC. Both types of drugs contained the estrogen ethinyl estradiol. No significant changes were noted in the norethindrone TOC group. The levonorgestrel TOC two-year test had a significant elevation of the 0.5- and 2-hour plasma glucose values and the fasting insulin value. These data show that the two triphasic oral contraceptive preparations affect carbohydrate metabolism differently.
Spellacy
W N
WN
Department of Obstetrics and Gynecology, University of Illinois College of Medicine 60612.
Ellingson
A B
AB
Tsibris
J C
JC
D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism*; D003277:Contraceptives, Oral, Combined / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D016912:Levonorgestrel; D009640:Norethindrone / Q000378:metabolism*; D009644:Norgestrel / Q000378:metabolism*; D011446:Prospective Studies
D001786:Blood Glucose; D003277:Contraceptives, Oral, Combined; D007328:Insulin; D009644:Norgestrel; D016912:Levonorgestrel; D009640:Norethindrone