Cyclosporine A prolonged survival time of parathyroid gland allograft in rats.
We divided the experimental animals into three groups. In the first group, only cyclosporine solvent containing no cyclosporine was given to rats. In the second group, cyclosporine A was given intraperitoneally from the 1st to the 5th days after transplantation at a daily dosage of 2 mg/100 g BW. In the third group, besides the first courses of cyclosporine A treatment as in group II, second and third courses were given on the 30th to 34th and 60th to 64th days after transplantation. Our results show that a relatively large dose given in a short course together with intermittent enhancement treatment proves much more effective than a short course without enhancement treatment.
He
X
X
PUMC Hospital, CAMS, Beijing.
Zhu
Y
Y
D000818:Animals; D002118:Calcium / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D010280:Parathyroid Glands / Q000637:transplantation*; D016105:Parathyroidectomy; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344
D003524:Cyclosporins; D002118:Calcium