title: The influence of posttraumatic parenteral calorie and nitrogen supply upon the cumulative nitrogen balance.
abstract: The aim of the study was to describe the influence of posttraumatic calorie and nitrogen (N) supply upon the cumulative N-balance by analyzing the literature of the past 18 years. Three groups of patients were formed, in which nutritional therapy was performed following trauma of differing severity: (1) patients following moderate trauma-N-losses 10-15 g/day; (2) patients following severe trauma--N-losses 15-20 g/day; and (3) polytraumatised patients--N-losses more than 20 g/day. The data gained for the calorie and N-supplies as well as for the N-balances in each group of patients served as a basis for the calculation of regression analyses of higher order; in these the cumulative N-balance was regarded as a function of the calorie and the N-supply: NBcum = f (C, N) Whilst for the group of polytraumatized patients only statements for a nutrient supply of about 20-30 kcal/kg BW/day and 0.2-0.3 g N/kg BW/day are possible, due to the limited data available, general statements about the different influence of calorie and N-supply can be made for nutritional therapy after moderate and major trauma; the calculated functions reveal that the N-supply influences the N-balance decisively, whereas the calorie supply exerts only a slight N-sparing effect. The mathematically calculated optimum of the N-supply after severe trauma is 0.2 g/kg BW/day, corresponding to an amino acid supply of 1.25 g/kg BW/day.
authors.affiliation: Clinic of Anaesthesiology, Medical Faculty, University of Technology, Aachen, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Behrendt
authors.forename: V
authors.initials: V
authors.lastname: Bogatz
authors.forename: G
authors.initials: G
authors.lastname: Giani
mesh_terms: D000465:Algorithms; D002149:Energy Intake / Q000502:physiology*; D006801:Humans; D009104:Multiple Trauma / Q000503:physiopathology / Q000628:therapy*; D009584:Nitrogen / Q000008:administration & dosage* / Q000378:metabolism; D009751:Nutritional Requirements; D010289:Parenteral Nutrition, Total / Q000379:methods*; D011183:Postoperative Complications / Q000503:physiopathology / Q000628:therapy*; D012984:Software
chemical_list: D009584:Nitrogen