title: [Prophylactic effect of UFT on the recurrence of bladder cancer].
abstract: To evaluate the effect of UFT, a mixture of ftorafur and uracil in a ratio of 1:4, in preventing postoperative recurrence of bladder cancer, we performed a randomized controlled study with a non-medication group as control. UFT was given orally 400 mg a day for 6 months. Of 111 patients, 56 were given UFT and 55 were followed up without any medication. The non-recurrence rate in the group treated with UFT was 62.8% after 1 year and 36.3% after 2 years of follow up, and that of the control group was 45.7% and 39.5%, respectively. The rate of non-recurrence in the UFT group was significantly higher (p less than 0.05) than that of the control group during the period of follow up for 2 years. The incidence of side effects was 6.8% in UFT patients. These results indicate the clinical usefulness of prophylactic administration of UFT for bladder cancer patients.
authors.affiliation: Department of Urology, School of Medicine, Kanazawa University.
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Hisazumi
authors.forename: A
authors.initials: A
authors.lastname: Saka
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Kanda
authors.forename: I
authors.initials: I
authors.lastname: Mikawa
authors.forename: S
authors.initials: S
authors.lastname: Ejiri
authors.forename: T
authors.initials: T
authors.lastname: Miyagi
authors.forename: T
authors.initials: T
authors.lastname: Katsumi
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery
chemical_list: D005641:Tegafur; D014498:Uracil