Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers.
The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2, CLs, Vd and F) were calculated using the clearance approach.
Arnera
V
V
Clinical Pharmacology, Zyma S.A., Nyon, Switzerland.
Wermeille
M
M
Wellman
M
M
Llull
J B
JB
Althaus
M A
MA
Balant
L P
LP
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002849:Chromatography, Gas; D004115:Dimethindene / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004797:Enzyme-Linked Immunosorbent Assay; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D004115:Dimethindene