Evaluation of clinical isolates of Pseudomonas aeruginosa for ribosomal resistance to tobramycin.
The suggested use of tobramycin in selective decontamination of the digestive tract led to the investigation of the part played clinically by ribosomal resistance in Pseudomonas aeruginosa. Examination of 32 tobramycin-resistant isolates, both enzyme and non-enzyme producing, suggests that ribosomal resistance is clinically important.
Botha
P
P
Department of Medical Microbiology, University of the Orange Free State, Bloemfontein.
de Kock
M J
MJ
van Vuuren
C J
CJ
Fourie
S
S
van Heerden
C
C
D000818:Animals; D004352:Drug Resistance, Microbial; D005069:Evaluation Studies as Topic; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012270:Ribosomes / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology*
D014031:Tobramycin