title: Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties.
abstract: The requirements for activity in a tumour-photosensitizing drug are outlined. A series of metallo tetrasulphonatophthalocyanines are shown to be inactive in an in vivo assay of tumour photosensitization; however, some less water-soluble compounds (hydroxylated derivatives of octaethylchlorin and octaethylbacteriochlorin) are shown to possess promising activity.
authors.affiliation: Department of Chemistry, Queen Mary and Westfield College, London U.K.
authors.forename: R
authors.initials: R
authors.lastname: Bonnett
authors.forename: A N
authors.initials: AN
authors.lastname: Nizhnik
authors.forename: S G
authors.initials: SG
authors.lastname: White
authors.forename: M C
authors.initials: MC
authors.lastname: Berenbaum
mesh_terms: D000818:Animals; D002460:Cell Line; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C006969:chlorin