title: Prothrombinex-induced thrombosis and its management with regional plasminogen activator in hepatic failure.
abstract: Fulminant hepatic failure causes a bleeding diathesis as a result of impaired synthesis of hepatic clotting factors, thrombocytopenia, fibrinolysis and disseminated intravascular coagulation. Administration of clotting factor concentrates can cause thrombosis in patients with acute hepatic failure. Regional infusion of recombinant tissue-type plasminogen activator may be used to induce local thrombolysis. A case report of a five-year-old child is presented and the literature is reviewed.
authors.affiliation: Royal Children's Hospital, Parkville, Vic.
authors.forename: B J
authors.initials: BJ
authors.lastname: Anderson
authors.forename: S R
authors.initials: SR
authors.lastname: Keeley
authors.forename: N D
authors.initials: ND
authors.lastname: Johnson
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology; D001779:Blood Coagulation Factors / Q000009:adverse effects*; D001916:Brachial Artery; D002675:Child, Preschool; D005260:Female; D005542:Forearm / Q000098:blood supply; D006501:Hepatic Encephalopathy / Q000150:complications*; D006801:Humans; D011884:Radius / Q000098:blood supply; D011994:Recombinant Proteins; D013927:Thrombosis / Q000139:chemically induced* / Q000188:drug therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D001779:Blood Coagulation Factors; D011994:Recombinant Proteins; C025667:prothrombin complex concentrates; D010959:Tissue Plasminogen Activator