[Current role of the laboratory in the demonstration and follow up of monoclonal immunoglobulinopathy].
The interest of new methodologies (electrophoresis in agarose, immunofixation, quantitation of Ig G, Ig A, Ig M and light chains kappa/lambda ratio) to diagnose monoclonal gammopathies, was discussed. A strategy using a combination of these new procedures was exposed. Serum level of bêta-2 microglobulin can be used to monitor response to therapy in myeloma when the quantitation of monoclonal Ig is not possible.
Myara
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Laboratoire de Biochimie, Hôpital Broussais, Paris, France.
D000911:Antibodies, Monoclonal / Q000276:immunology; D001797:Blood Protein Electrophoresis; D019411:Clinical Laboratory Techniques / Q000639:trends*; D003449:Cryoglobulinemia / Q000145:classification / Q000175:diagnosis; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007122:Immunoelectrophoresis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis / Q000276:immunology*; D010265:Paraproteinemias / Q000175:diagnosis* / Q000276:immunology; D011507:Proteinuria / Q000175:diagnosis; D001613:beta 2-Microglobulin / Q000032:analysis
D000911:Antibodies, Monoclonal; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins; D001613:beta 2-Microglobulin
Rôle actuel du laboratoire dans la mise en évidence et le suivi d'une immunoglobulinopathie monoclonale.