[The evaluation of thyroid suppression test in predicting the outcome of Graves' disease treated by short-term antithyroid drugs].
One hundred and fifteen new patients with Graves' hyperthyroidism were received thyroid suppression test after cessation of 6 month course of drug therapy. The results of follow up for another 12 months were that one of them had lost, 48 cases were in remission, and 66 cases had relapsed. The present study shows that thyroid suppression test, including the 4th, 6th and 24th hour suppression rates, is useful in predicting the outcome of drug therapy. The effect of 6th hour suppression rate is better than that of 24th and 4th hours, with 75.8% sensitivity, 75.0% specificity and 75.4% accuracy when 30% of thyroid suppression rate is as out-off point which is decided by ROC curve. It is suggested that 6 hour 30% suppression rate is better than the traditional 24 hour 50% suppression rate in the prediction of outcome of drug therapy.
Wei
S
S
Cheng
Y
Y
Xu
S
S
Li
W
W
Deng
H
H
D000328:Adult; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008713:Methimazole / Q000008:administration & dosage* / Q000627:therapeutic use; D011379:Prognosis; D013960:Thyroid Function Tests
D007457:Iodine Radioisotopes; D008713:Methimazole