title: DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.
abstract: To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".
authors.affiliation: Institut für Immunologie, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Blankenstein
authors.forename: Z H
authors.initials: ZH
authors.lastname: Qin
authors.forename: W Q
authors.initials: WQ
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Diamantstein
mesh_terms: D000818:Animals; D001483:Base Sequence; D015321:Gene Rearrangement; D007426:Genes, Intracisternal A-Particle; D015850:Interleukin-6 / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D010954:Plasmacytoma / Q000235:genetics*
chemical_list: D015850:Interleukin-6