title: Development of long-acting nitrate delivery systems.
abstract: In this paper pharmaceutical and biopharmaceutical aspects on the development of long-acting nitrate delivery systems are reviewed. Basic considerations and requirements are also discussed. Recent product development activities are presented, with an emphasis on nitroglycerin in transdermal form and oral isosorbide-5-mononitrate controlled-release formulations.
authors.affiliation: Pharmaceutical Research and Development, AB Hässle, Mölndal, Sweden.
authors.forename: U E
authors.initials: UE
authors.lastname: Jonsson
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000787:Angina Pectoris / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D009566:Nitrates / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage
chemical_list: D003692:Delayed-Action Preparations; D009566:Nitrates; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate