[Clinical study of fifty cases of Klinefelter's syndrome].
The authors report the clinical manifestations of 50 cases of Klinefelter's Syndrome proven by chromosome studies. The number of cases with the genotype of 47 XXY, 46 XY/47 XXY, 46 XX/47 XXY and 48 XXXY were 42, 6, 1 and 1 respectively. The chief complaint of 68% of the patients was maldevelopment of sex and that of 26% was gynecomastia. One fourth of the patients was born when their mothers' age already exceeded 35. About 1/5 had low intelligence. Secondary sexual characteristics were absent in all the patients. About 2/5 had gynecomastia. The average testicular volume was 4.0-1.3 ml, but no sperm was found in their semen. Their serum testosterone concentration decreased to 5.4 +/- 5.3 mM/L, but the serum TeBG, FSH and LH levels were significantly increased to 66.8 +/- 22.0 nM/L, 24.7 +/- 7.1 IU/L and 12.3 +/- 7.3 IU/L.
Xiang
H D
HD
Department of Endocrinology, Peking Uning Medical College Hospital, Beijing.
Shi
Y F
YF
Wu
Q Y
QY
D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006177:Gynecomastia / Q000150:complications; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications / Q000175:diagnosis*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone