title: Structure of a hepatotoxic pentapeptide from the cyanobacterium Nodularia spumigena.
abstract: The structure of a hepatotoxic peptide from the cyanobacterium Nodularia spumigena was determined using 1D and 2D proton nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. The toxin was a cyclic pentapeptide (mol. wt 824.5) with the structure cyclo-(beta-methylisoAsp-Arg-Adda-isoGlu-N-methylde hydrobutyric acid) (Adda: 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid).
authors.affiliation: Department of Bioorganic Chemistry, University of Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sandström
authors.forename: C
authors.initials: C
authors.lastname: Glemarec
authors.forename: J A
authors.initials: JA
authors.lastname: Meriluoto
authors.forename: J E
authors.initials: JE
authors.lastname: Eriksson
authors.forename: J
authors.initials: J
authors.lastname: Chattopadhyaya
mesh_terms: D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000633:toxicity*; D000458:Cyanobacteria; D008099:Liver / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism; D010084:Oxidation-Reduction; D014269:Trifluoroacetic Acid / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D009842:Oligopeptides; D014269:Trifluoroacetic Acid