Glucose alters rat liver S9-mediated mutagenesis, metabolism and DNA-binding of aflatoxin B1.
The administration of 30% glucose in drinking water to rats for 48 h caused a significant increase in the hepatic S9-mediated mutagenicity of aflatoxin B1, in Salmonella typhimurium TA100 and in the binding of alfatoxin B1, to calf thymus DNA in vitro. These effects correlated with a reduction in the metabolism and detoxification of aflatoxin B1, by S9 from glucose-treated rats and suggest that the oral intake of sugar may affect the hepatocarcinogenicity of aflatoxin B1.
Teel
R W
RW
Department of Physiology and Pharmacology, Loma Linda University School of Medicine, CA 92350.
Strother
A
A
D000284:Administration, Oral; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008110:Liver Extracts / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D000348:Aflatoxins; D008110:Liver Extracts; D014316:Tritium; D004247:DNA; D016604:Aflatoxin B1; D005947:Glucose