Are accessory molecules implicated in activation of T cells at the blood-retinal barrier?
Co-culture of rat retinal pigment epithelial (RPE) cells or retinal capillary endothelial (EC) cells with T lymphocytes from immunised syngeneic rats indicated that RPE cells but not EC could process retinal S-antigen and induce antigen specific T cell activation. Activation of lymphocytes by EC however was also antigen independent, and may be due to T cell (CD2) endothelial cell (LFA-3) ligand interactions which are functional on EC but not RPE.
Liversidge
J
J
Department of Ophthalmology, University of Aberdeen, UK.
Forrester
J V
JV
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology / Q000302:isolation & purification; D019393:Arrestin; D001813:Blood-Retinal Barrier / Q000276:immunology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology*; D005136:Eye Proteins / Q000276:immunology / Q000302:isolation & purification; D007371:Interferon-gamma / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000276:immunology*; D051381:Rats; D012171:Retinal Vessels / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D007371:Interferon-gamma