Sites of photosensitization by protoporphyrin and tin protoporphyrin in leukemia L1210 cells.
Studies with protoporphyrin (PP) and tin protoporphyrin (SnPP) were carried out to assess the effects of tin insertion on the sites of dye localization. Fluorescence emission spectra and studies on the sites of photodamage were consistent with a concentration of PP at membrane loci. In contrast, SnPP photodamage involved an intracellular site.
Kessel
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D
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201.
Schulz
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V
D000818:Animals; D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects; D003624:Darkness; D007939:Leukemia L1210 / Q000378:metabolism*; D008027:Light; D008665:Metalloporphyrins / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D011524:Protoporphyrins / Q000378:metabolism / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D008665:Metalloporphyrins; D011524:Protoporphyrins; D011838:Radiation-Sensitizing Agents; C032628:tin protoporphyrin IX