Aging and calcium metabolism.
It is imperative to understand calcium metabolism under a unified concept, despite the vast concentration difference among the three major calcium compartments in human body. Total body calcium homeostasis supported by adequate calcium intake and normal skeletal metabolism is quite important to maintain adequate extra- and intracellular calcium concentration gradient and consequent signal transduction system mediated by calcium entry into the cell. Aging and diseases are associated with blunting of the calcium concentration gradient, due to calcium deficiency and consequent secondary hyperparathyroidism.
Fujita
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Department of Medicine, Kobe University School of Medicine, Japan.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D001825:Body Fluid Compartments; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D005399:Fishes / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D006973:Hypertension / Q000378:metabolism; D006996:Hypocalcemia / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D010281:Parathyroid Hormone / Q000502:physiology; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism
D010281:Parathyroid Hormone; D014807:Vitamin D; D002116:Calcitonin; D002118:Calcium