Synthesis and in vivo activity of some porphyrindione derivatives with potential in photodynamic therapy.
A number of synthetic bacteriochlorins were prepared from porphyrindiones. The potential of these compounds as sensitizers for photodynamic therapy was examined using the FANFT-induced urothelial cell carcinoma (AY-27) transplanted into rats. In a number of cases, tumor regression was significant following treatment with both drug and light.
Morgan
A R
AR
Department of Chemistry University of Toledo, OH 43606.
Garbo
G M
GM
Keck
R W
RW
Skalkos
D
D
Selman
S H
SH
D000818:Animals; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis* / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis*; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D007202:Indicators and Reagents; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents