title: The role of B cells for in vivo T cell responses to a Friend virus-induced leukemia.
abstract: B cells can function as antigen-presenting cells and accessory cells for T cell responses. This study evaluated the role of B cells in the induction of protective T cell immunity to a Friend murine leukemia virus (F-MuLV)-induced leukemia (FBL). B cell-deficient mice exhibited significantly reduced tumor-specific CD4+ helper and CD8+ cytotoxic T cell responses after priming with FBL or a recombinant vaccinia virus containing F-MuLV antigens. Moreover, these mice had diminished T cell responses to the vaccinia viral antigens. Tumor-primed T cells transferred into B cell-deficient mice effectively eradicated disseminated FBL. Thus, B cells appear necessary for efficient priming but not expression of tumor and viral T cell immunity.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle 98195.
authors.forename: K R
authors.initials: KR
authors.lastname: Schultz
authors.forename: J P
authors.initials: JP
authors.lastname: Klarnet
authors.forename: R S
authors.initials: RS
authors.lastname: Gieni
authors.forename: K T
authors.initials: KT
authors.lastname: HayGlass
authors.forename: P D
authors.initials: PD
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D005622:Friend murine leukemia virus / Q000276:immunology*; D005805:Genes, MHC Class I; D007116:Immunization, Passive; D007942:Leukemia, Experimental / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens