title: Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging.
abstract: Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor.
authors.affiliation: Department of Radiology, Children's Medical Center, Dallas, TX 75235.
authors.forename: N
authors.initials: N
authors.lastname: Rollins
authors.forename: D
authors.initials: D
authors.lastname: Mendelsohn
authors.forename: A
authors.initials: A
authors.lastname: Mulne
authors.forename: R
authors.initials: R
authors.lastname: Barton
authors.forename: J
authors.initials: J
authors.lastname: Diehl
authors.forename: N
authors.initials: N
authors.lastname: Reyes
authors.forename: F
authors.initials: F
authors.lastname: Sklar
mesh_terms: D000293:Adolescent; D001812:Blood-Brain Barrier / Q000528:radiation effects; D002528:Cerebellar Neoplasms / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008527:Medulloblastoma / Q000175:diagnosis*; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011832:Radiation Injuries / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA