Response of tumor and host to hyperalimentation and antiglutamine treatments.
In two experiments, treatment of tumor-bearing (TB) rats with the glutamine antimetabolite, acivicin, reduced tumor growth during 14 days of total parenteral nutrition (TPN) that supplied 120% and 130% of the nutritional intake of non-TB control rats. The acivicin treatment or combination of acivicin with TPN produced increased carcass weights and decreased tumor/carcass ratios. Significant muscle saving was observed in TB rats receiving TPN or TPN and acivicin as compared to acivicin-treated TB rats maintained on rat chow. Tumor growth was not stimulated by TPN at 130% of ad libitum. intake with a calorie/nitrogen ratio of 102:1. However, when the calorie/nitrogen ratio was increased to 143:1, tumor growth was increased by TPN at 120% of ad libitum. intake. These results suggest that acivicin may prove useful in the stabilization of tumors in situations where tumor growth may be stimulated, such as during TPN.
Chance
W T
WT
Department of Surgery, University of Cincinnati Medical Center, Ohio.
Cao
L Q
LQ
Fischer
J E
JE
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000963:Antimetabolites / Q000627:therapeutic use*; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D010080:Oxazoles / Q000627:therapeutic use*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000628:therapy*
D000903:Antibiotics, Antineoplastic; D000963:Antimetabolites; D007555:Isoxazoles; D010080:Oxazoles; C006303:acivicin