[The effect of benzofurocaine on acute inflammation in rats and on the activity of prostaglandin synthetase in vitro].
Benzofurocaine similarly to ortophen (voltaren) causes dose-dependent suppression of acute inflammatory reactions induced in rats by carragheenin, serotonin and histamine, protects animals from absolutely lethal dose of cellulose sulphate. When administered in a dose of 0.79 X 10(-3) M, benzofurocaine exerts no effect on the activity of prostaglandin synthetase.
Stepaniuk
G I
GI
Stoliarchuk
A A
AA
Mevkh
A T
AT
Igumnova
N D
ND
D000208:Acute Disease; D000779:Anesthetics, Local / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001572:Benzofurans; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects / Q000201:enzymology
D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac; C040205:benzofurocaine
Vliianie benzofurokaina na ostroe vospalenie u krys i aktivnost' prostaglandinsintetazy in vitro.