Syntheses of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-cysteine and of some isotopically labelled (2H, 13C) analogues.
The chemical syntheses of human metabolites of S-carboxymethyl-L-cysteine (3) and S-methyl-L-cysteine (12) are described. The additional preparation of some 2H- and 13C-labelled isotopomers enabled the direct evaluation of the stabilities of 3 and 12 under physiological conditions and also facilitated the unambiguous assignments of the signals in the 13C-NMR spectra of all compounds mentioned.
Meese
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Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, FRG.
Specht
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Hofmann
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D002233:Carbocysteine / Q000138:chemical synthesis* / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy
D002233:Carbocysteine; C008425:S-methylcysteine; D003545:Cysteine