Effect of Asparagus racemosus (Shatavari) on gastric emptying time in normal healthy volunteers.
Asparagus racemosus (Shatavari) is used in Ayurveda for dyspepsia (amlapitta) and as a galactogogue. It was hence compared with a modern drug, metoclopramide, which is used in dyspepsia to reduce gastric emptying time. Gastric emptying half- time (GE t1/2) was studied in 8 healthy male volunteers using a cross-over design. The basal GE t1/2 in volunteers was 159.9 +/- 45.9 min (mean +/- SD) which was reduced to 101 +/- 40.8 min by Shatavari (p less than 0.001) and to 85.3 +/- 21.9 by metoclopramide (p less than 0.001). Metoclopramide and Shatavari did not differ significantly in their effects.
Dalvi
S S
SS
Department of Pharmacology, Seth G. S. Medical College, Bombay, Maharashtra.
Nadkarni
P M
PM
Gupta
K C
KC
D000328:Adult; D000818:Animals; D018492:Dopamine Antagonists; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008515:Medicine, Ayurvedic; D008787:Metoclopramide / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D018492:Dopamine Antagonists; D010936:Plant Extracts; D008787:Metoclopramide