title: Intestinal permeability in irritable bowel syndrome. Effect of diet and sodium cromoglycate administration.
abstract: We studied 14 patients with irritable bowel syndrome for the presence of increased intestinal permeability to food antigens and their responses to diet with and without disodium cromoglycate. After a standardized oral challenge with cow milk, serum beta-lactoglobulin was increased above control values in three patients. This finding did not correlate with response to hypoallergenic diet or treatment with disodium cromoglycate for 3 weeks. However over 50% of patients improved after diet with and without DSCG (2/5 on diet only and 5/7 with disodium cromoglycate of 12 evaluable cases). Since only two patients had elevated serum IgE levels, our results suggest that intolerance rather than hypersensitivity to foods may play a role in the disease. The tests we used to identify immunologic mechanisms could not predict which patients would do better on the diet and/or the drug.
authors.affiliation: Department of Allergy and Clinical Immunology, University La Sapienza, Rome.
authors.forename: R
authors.initials: R
authors.lastname: Paganelli
authors.forename: U
authors.initials: U
authors.lastname: Fagiolo
authors.forename: M
authors.initials: M
authors.lastname: Cancian
authors.forename: G C
authors.initials: GC
authors.lastname: Sturniolo
authors.forename: E
authors.initials: E
authors.lastname: Scala
authors.forename: G P
authors.initials: GP
authors.lastname: D'Offizi
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D003109:Colonic Diseases, Functional / Q000378:metabolism*; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000494:pharmacology; D004032:Diet; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007413:Intestinal Mucosa / Q000378:metabolism*; D007782:Lactoglobulins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000276:immunology; D010539:Permeability / Q000187:drug effects
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007074:Immunoglobulin G; D007782:Lactoglobulins; D007073:Immunoglobulin E; D004205:Cromolyn Sodium