title: [The determination of the optimal inoculation dose of an oral cholera chemical bivalent vaccine in a controlled experiment].
abstract: 276 volunteers aged 19 years and over were placed under observation in the course of the trial of oral cholera vaccine in tablets, containing choleragen toxoid, O-antigens of serovars Inaba and Ogawa and a number of Vibrio cholerae exoenzymes, for safety, reactogenic properties and immunological effectiveness. The vaccine was found to produce no reactions in a dose of 1-4 tablets; the administration of 3 tablets (300,000 binding units of the toxoid and 10,000 units of O-antigens, serovars Inaba and Ogawa) was shown to induce the most intensive synthesis of both antitoxins and vibriocidal antibodies in the blood sera of volunteers, as well as IgA coproantibodies. The oral vaccine was found to have an advantage over parenteral vaccines due to the absence of reactogenic properties and the formation of local immunity: coproantibodies appeared in 80% and 9% of the vaccinees respectively.
authors.forename: A A
authors.initials: AA
authors.lastname: Sumarokov
authors.forename: N R
authors.initials: NR
authors.lastname: Ivanov
authors.forename: M N
authors.initials: MN
authors.lastname: Dzhaparidze
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Reznikov
authors.forename: E A
authors.initials: EA
authors.lastname: Rystsova
authors.forename: G P
authors.initials: GP
authors.lastname: Nikitina
authors.forename: L Ia
authors.initials: LIa
authors.lastname: Matusevich
authors.forename: A A
authors.initials: AA
authors.lastname: Popov
authors.forename: M N
authors.initials: MN
authors.lastname: Plotnikova
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Shustov
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D000075202:Contraindications; D005243:Feces / Q000737:chemistry; D006801:Humans; D007114:Immunization; D013607:Tablets; D013997:Time Factors; D014734:Vibrio cholerae / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D013607:Tablets
vernacular_title: Opredelenie optimal'noĭ privivochnoĭ dozy oral'noĭ kholernoĭ khimicheskoĭ bivalentnoĭ vaktsiny v kontroliruemom opyte.