Chromatographic studies on the binding, action and metabolism of (-)-deprenyl.
Serum binding, the effect on striatal dopamine release and the metabolism of (-)-deprenyl [N-methyl-N-propargyl(2-phenyl-1-methyl)ethylammonium chloride], TZ-650 [N-methyl-N-propargyl(2-phenyl)ethylammonium chloride] and J-508 [N-methyl-N-propargyl(indanyl)ammonium chloride] were investigated using various chromatographic methods. A strong interaction between (-)-deprenyl and macroglobulins was found. Deprenyl enhanced the dopamine release from striatal slices of the rat brain and also inhibited the dopamine-DOPAC conversion. Deprenyl analogues showed either smaller or no effect. Hydroxylation of (-)-deprenyl takes place in the para position, in addition to the usual oxidative N-dealkylations, which are known from various metabolic studies on N-substituted phenylalkylamines.
Kalász
H
H
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Kerecsen
L
L
Knoll
J
J
Pucsok
J
J
D000818:Animals; D002845:Chromatography / Q000379:methods*; D005260:Female; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D010627:Phenethylamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000032:analysis / Q000378:metabolism* / Q000627:therapeutic use
D010627:Phenethylamines; D012642:Selegiline