Antitumor activity of methyl-4 H-1,2,4-benzothiadiazin-3-yl-carbamodithioate-S,S,-dioxide.
The antitumor activity of the methyl-6-chloro-4H-1,2,4-benzothiadiazin-3-yl-S-carbamothioate+ ++-S,S,-dioxide (1) and the methyl-4H-1,2,4-benzothiadiazin-3-yl-carbamodithioate-S,S-di oxide (2), has been evaluated. Compound 2 passed activity criteria for leukemia P388 and was also moderately active against transplanted mouse tumor L1210 leukemia and M5076 sarcoma.
Tait
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A
Dipartimento di Scienze Farmaceutiche, University of Modena, Italy.
Di Bella
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M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013829:Thiadiazines / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*
D000970:Antineoplastic Agents; D013829:Thiadiazines; D013859:Thiocarbamates; C069411:methyl-4H-1,2,4-benzothiadiazin-3-yl-carbamodithioate-S,S-dioxide