Interferon-gamma enhances mRNA and surface expression of class I antigen on human extravillous trophoblast.
Human trophoblast cells with immunocytochemical characteristics of the extravillous population have been isolated from 1st trimester placentae. Treatment of these cells with IFN-gamma increases the expression of Class I antigens at both the cell surface and mRNA level. A similar increase in Class I antigens is also found in JEG-3 choriocarcinoma cells after treatment with IFN-gamma. The possibility that aberrant production of IFN-gamma may upset the fetal-maternal equilibrium in vivo is discussed.
Grabowska
A
A
Department of Pathology, University of Cambridge, UK.
Chumbley
G
G
Carter
N
N
Loke
Y W
YW
D000954:Antigens, Surface / Q000096:biosynthesis; D015152:Blotting, Northern; D002478:Cells, Cultured; D002822:Choriocarcinoma / Q000378:metabolism; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D012333:RNA, Messenger / Q000187:drug effects*; D014327:Trophoblasts / Q000378:metabolism
D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger; D007371:Interferon-gamma