title: Effect of prolonged physical exercise on the fibrinolytic system.
abstract: The effect of a test marathon race on plasma fibrinolytic activity (FA) was studied in 16 endurance athletes before, immediately after, 3 h, and 31 h after the run. Tissue plasminogen activator (t-PA) activity increased about 31-fold immediately after the run. Similar increases were found in t-PA antigen concentration. Plasminogen activator inhibitor (PAI) was not detectable immediately after the race and was significantly decreased 3 h (P less than 0.05) and 31 h (P less than 0.01) later. B beta 15-42 peptide increased by 0.63 pmol.ml-1 (P less than 0.001), D-dimer by 68.3 ng.ml-1 (P less than 0.05). Euglobulin lysis time (ELT) was reduced from 109 to 18 min (P less than 0.001). The increased t-PA activity and t-PA antigen concentration disappeared in the course of the first 3 h after exertion. ELT also reached its pre-exercise levels at this time. Thirty-one hours after the race ELT and t-PA antigen levels were slightly but significantly reduced (P less than 0.05), whereas B beta 15-42 peptide remained increased (P less than 0.05). t-PA activity was unchanged compared with pre-exercise values. It seems that the exercise-induced FA is mainly caused by the marked increase of t-PA antigen and t-PA activity.
authors.affiliation: Institut für Leistungsmedizin (LLZ), FU Berlin, Federal Republic of Germany.
authors.forename: L
authors.initials: L
authors.lastname: Röcker
authors.forename: M
authors.initials: M
authors.lastname: Taenzer
authors.forename: W K
authors.initials: WK
authors.lastname: Drygas
authors.forename: H
authors.initials: H
authors.lastname: Lill
authors.forename: B
authors.initials: B
authors.lastname: Heyduck
authors.forename: H U
authors.initials: HU
authors.lastname: Altenkirch
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D015444:Exercise; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010447:Peptide Hydrolases / Q000378:metabolism; D010807:Physical Endurance; D011517:Prothrombin Time; D012420:Running; D012712:Serum Globulins / Q000378:metabolism; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D012712:Serum Globulins; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator