Membrane-associated crystallization of calcium oxalate in vitro.
Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.
Khan
S R
SR
Department of Pathology, College of Medicine, University of Florida, Gainesville 22610.
Shevock
P N
PN
Hackett
R L
RL
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D003460:Crystallization; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D051381:Rats; D014545:Urinary Calculi / Q000378:metabolism / Q000503:physiopathology
D002129:Calcium Oxalate