Pilot study to determine the interaction of oxiracetam with antiepileptic drugs.
Oxiracetam, a nootropic drug, could be of potential use in the treatment of memory disturbances in patients with epilepsy who are using antiepileptic drugs. The half-life of oxiracetam appears to be influenced by the concomitant use of carbamazepine or valproic acid, necessitating more frequent administration of oxiracetam than is recommended for other conditions. No effect was observed on the serum concentrations of these antiepileptic drugs by oxiracetam. Long term concurrent use of oxiracetam and antiepileptic agents does not appear to be contraindicated.
van Wieringen
A
A
Institut voor Epilepsiebestrijding, Heemstede, The Netherlands.
Meijer
J W
JW
van Emde Boas
W
W
Vermeij
T A
TA
D000328:Adult; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D000078306:Clobazam; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011619:Psychotropic Drugs / Q000097:blood / Q000493:pharmacokinetics*; D011759:Pyrrolidines / Q000097:blood / Q000493:pharmacokinetics*; D014635:Valproic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D011619:Psychotropic Drugs; D011759:Pyrrolidines; D001569:Benzodiazepines; D000078306:Clobazam; D002220:Carbamazepine; D014635:Valproic Acid; C040619:oxiracetam