title: [Gonadotropic function of the hypophysis in girls with delayed puberty].
abstract: Radioimmune assay of serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 216 girls aged 13-18 years with pubertal delay (PD) unrelated to gonadal dysgenesis have shown that LH and FSH levels were normal in 48.1%; one or both gonadotropins were decreased in 17.1%, only LH level was increased in 13.9% and only FSH level in 12.6%. Hypergonadotropinemia was seen in 8.3% of the patients. Bioassay of total gonadotropin excretion was performed in 117 patients. Comparison of the radioimmune and biological assays suggested misproduction of the biologically active gonadotropins in a proportion of girls with PD. Hypoestrogenism in normogonadotropic PD appears to be related to regional blood and lymph flow disturbance.
authors.forename: S A
authors.initials: SA
authors.lastname: Levenets
authors.forename: E I
authors.initials: EI
authors.lastname: Plekhova
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Cherevatova
mesh_terms: D000293:Adolescent; D001681:Biological Assay; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D011628:Puberty, Delayed / Q000097:blood*; D011863:Radioimmunoassay
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Kharakter gonadotropnoĭ funktsii gipofiza u devochek s zaderzhkoĭ polovogo razvitiia.