[Studies on uranium mobilization agents. IV. Synthesis of N, N'-bis-[N-carboxymethyl-(2,3-dihydroxy-5-carbomethoxy) benzylaminoacetyl]-alpha, omega-diamines].
In continuation of searching for effective antidotes against uranium intoxication, a series of N,N'-bis-[N-carboxymethyl-(2,3-dihydroxy-5-carbomethoxy) benzylaminoacetyl]-alpha, omega-diamines was synthesized by reacting 2,3-dihydroxy-5-carbomethoxybenzylamine diacetic acid with diamines of different chain lengths. Their effects on the elimination of uranyl nitrate from rats were tested. Most of them were found to be more effective than the reported uranium chelating agents as Tiron and Phosphicine and compound IIa was shown to be the most promising. The results of pharmacological studies will be published elsewhere.
Chen
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WZ
Shanghai Institute of Materia Medica, Academia Sinica.
Xie
Y Y
YY
D000818:Animals; D000931:Antidotes / Q000138:chemical synthesis*; D002614:Chelating Agents / Q000138:chemical synthesis; D003959:Diamines / Q000138:chemical synthesis*; D062385:Hydroxybenzoates / Q000138:chemical synthesis*; D051381:Rats; D014501:Uranium
D000931:Antidotes; D002614:Chelating Agents; D003959:Diamines; D062385:Hydroxybenzoates; D014501:Uranium