[The effect of sodium valproate on the electrical stability of the heart in experimental myocardial infarct].
It was shown in experiments on rats that sodium valproate, an activator of the stress limiting GABAergic system, prevents drop of cardiac fibrillation electric threshold in experimental myocardial infarction and restricts the development of extra-systole occurring in stimulation of the vagus nerve in rats with myocardial infarction. The possible mechanism of this effect is discussed.
Shabunina
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EV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004562:Electrocardiography; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D014630:Vagus Nerve / Q000502:physiology; D014635:Valproic Acid / Q000627:therapeutic use*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control
D014635:Valproic Acid
Vliianie natriia val'proata na élektricheskuiu stabil'nost' serdtsa pri éksperimental'nom infarkte miokarda.