A review of techniques for the analysis of boron in the development of neutron capture therapy agents.
The resurgence of interest in neutron capture therapy, which uses boron-10 labelled compounds and neutron irradiation as a technique for the treatment of cancer, has been accompanied by the application of a new generation of techniques for the analysis and imaging of boron in biological matrices. In this review, a description is given of the requirements for boron neutron capture agents and the achievements to date of the analytical techniques.
Moore
D E
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Department of Pharmacy, University of Sydney, Australia.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001895:Boron / Q000032:analysis* / Q000627:therapeutic use; D002151:Calorimetry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D009369:Neoplasms / Q000628:therapy; D013054:Spectrophotometry, Atomic / Q000379:methods
D000970:Antineoplastic Agents; D001895:Boron