[Tau protein and beta protein].
The main pathological features of Alzheimer's disease are Alzheimer neurofibrillary tangles and senile plaques. Recent biochemical research revealed that tangles are composed of tau protein and ubiquitin and amyloid in senile plaques is composed of beta protein which is a fragment of the membrane receptor protein. Although fraction, other data suggest that whole molecules become abnormal and aggregate into PHF. On the other hand, beta protein is a small cleavage product of the precursor protein. It is not concluded yet whether abnormal precursor proteins exist or not. Recent research in this field is reviewed.
Nukina
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Department of Neurology, Tokyo University.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009454:Neurofibrils / Q000378:metabolism; D016875:tau Proteins
D016229:Amyloid beta-Peptides; D008869:Microtubule-Associated Proteins; D016875:tau Proteins