title: Reversed-phase high-performance liquid chromatographic method for the assay of 1,4-dioxane in sulphated polyoxyethylene alcohol surfactants.
abstract: A rapid high-performance liquid chromatographic method has been developed for the assay of 1,4-dioxane in ethoxylated fatty alcohol sulphates. After solid-phase extraction using Bakerbond C18 cartridges, samples were directly analysed on a LiChrospher CH-8 reversed-phase column with UV detection at 200 nm and an acetonitrile-water eluent. Recovery of 1,4-dioxane from the surfactant matrix was 95.7% in the 40 to 120 micrograms g-1 range. The minimum quantifiable amount was 18 micrograms g-1. The procedure is simple, reproducible, specific and suitable for routine analyses of commercial surfactants.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Scalia
mesh_terms: D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004146:Dioxanes / Q000032:analysis*; D011092:Polyethylene Glycols; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents
chemical_list: D004146:Dioxanes; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; C025223:1,4-dioxane