title: Presence of gamma interferon in human acute and congenital toxoplasmosis.
abstract: The production of gamma interferon in acute acquired and congenital toxoplasmosis was studied. Gamma interferon was produced at significant titers (P less than 0.001) in the course of both congenital toxoplasmosis and acquired toxoplasmosis at an early stage of infection, when Toxoplasma gondii was multiplying. Its presence in fetal blood was correlated with the positive inoculation of fetal blood or amniotic fluid into mice (95%). The data suggest that the fetus is able to synthesize gamma interferon as early as week 21 of pregnancy. This test, easily and rapidly performed, could be included among those useful for diagnosing fetal toxoplasmic disease.
authors.affiliation: Service de Microbiologie, Hôpital Saint Vincent de Paul, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Raymond
authors.forename: M H
authors.initials: MH
authors.lastname: Poissonnier
authors.forename: P H
authors.initials: PH
authors.lastname: Thulliez
authors.forename: F
authors.initials: F
authors.lastname: Forestier
authors.forename: F
authors.initials: F
authors.lastname: Daffos
authors.forename: P
authors.initials: P
authors.lastname: Lebon
mesh_terms: D000208:Acute Disease; D015415:Biomarkers; D005260:Female; D005312:Fetal Blood / Q000382:microbiology; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014123:Toxoplasmosis / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000276:immunology*
chemical_list: D015415:Biomarkers; D007371:Interferon-gamma