Evidence for a reduced heparin cofactor II biological activity in diabetes.
A reduction of heparin cofactor II (HCII) biological activity, despite its normal plasma concentration, is reported in insulin-dependent diabetic patients. A good linear correlation between HCII activity and concentration is present in normal controls but not in diabetics. In these subjects HCII activity correlates inversely with fasting blood glucose and glycated proteins but not with Hb A1. These data demonstrate the presence of a depressed HCII activity in the presence of its normal plasma concentration in insulin-dependent diabetics and suggest a role for short-term metabolic control in conditioning this phenomenon.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italia.
Quatraro
A
A
Dello Russo
P
P
Marchi
E
E
Milani
M R
MR
Giugliano
D
D
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D015844:Heparin Cofactor II / Q000378:metabolism*; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male
D001786:Blood Glucose; D001798:Blood Proteins; D015844:Heparin Cofactor II