title: A three-year evaluation of hemostatic function in Singaporean Norplant acceptors.
abstract: In a longitudinal study involving 100 Singaporean women, results indicate that the acceptors persist in having a possibly increased predisposition to thrombosis, as evidenced by a significant increase in platelet count and aggregability. Furthermore, the shortened prothrombin time and activated partial thromboplastin time, together with changes in vitamin K factors, still indicate the possible enhanced potential for hypercoagulation.
authors.affiliation: Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D001779:Blood Coagulation Factors / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D004343:Drug Implants; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel; D008137:Longitudinal Studies; D009644:Norgestrel / Q000009:adverse effects / Q000494:pharmacology*; D013927:Thrombosis / Q000139:chemically induced
chemical_list: D001779:Blood Coagulation Factors; D003271:Contraceptive Agents, Female; D004343:Drug Implants; D009644:Norgestrel; D016912:Levonorgestrel