[Changes in phagocytosis of aerobic bacteria by neutrophils after exposure to subinhibitory concentrations of aztreonam and ciprofloxacin].
In the present research work we are performing a study on the effect of the antibiotic concentrations low minimal inhibitory concentration of aztreonam and ciprofloxacin on phagocytosis of aerobic bacteria by neutrophils (Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa). Both antibiotics induced an increased of phagocytosis by similar mechanisms. In our assay aztreonam and ciprofloxacin would not act directly on granulocyte but they would affect the bacteria increasing the opsonization and phagocytosis.
Gutiérrez Fernández
J
J
Departamento de Microbiología, Hospital Universitario, Facultad de Medicina, Universidad de Granada.
Alados Arboledas
J C
JC
Castillo Pérez
A M
AM
Maroto Vela
M C
MC
Piedrola de Angulo
G
G
D001398:Aztreonam / Q000008:administration & dosage / Q000494:pharmacology*; D001420:Bacteria, Aerobic; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects*
D002939:Ciprofloxacin; D001398:Aztreonam
Modificación de la fagocitosis de bacterias aerobias por los neutrófilos tras la exposición a concentraciones subinhibitorias de aztreonam y ciprofloxacino.