title: More precise localization of the gene for Hunter syndrome.
abstract: A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27-Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene (Zmax = 6.57 at theta max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman et al. (1986, Arch. Dis. Child. 58: 911-915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection.
authors.affiliation: U.73 (INSERM), Génétique et pathologie foetale, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Le Guern
authors.forename: P
authors.initials: P
authors.lastname: Couillin
authors.forename: I
authors.initials: I
authors.lastname: Oberlé
authors.forename: N
authors.initials: N
authors.lastname: Ravise
authors.forename: J
authors.initials: J
authors.lastname: Boue
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008126:Lod Score; D008297:Male; D051379:Mice; D016532:Mucopolysaccharidosis II / Q000235:genetics*; D010375:Pedigree; D014960:X Chromosome
chemical_list: D005819:Genetic Markers