title: The prostacyclin analogue taprostene and recombinant human superoxide dismutase increase the permanent survival rate of endotoxemic rats.
abstract: The permanent survival rate of endotoxemic rats was studied. In 40 untreated control rats the survival rate 7 days after the endotoxin administration was 33%. The survival rate was increased to 40% with recombinant human superoxide dismutase (r-HSOD), to 55% (p less than 0.05) with the prostacyclin analogue Taprostene and to 70% (p less than 0.01) with the combination of r-HSOD and Taprostene (20 rats for each treatment group). r-HSOD and Taprostene provide significant and permanent protection in rat endotoxic shock.
authors.affiliation: Center of Research, Grünenthal GmbH, Aachen, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: T
authors.initials: T
authors.lastname: Matthiesen
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D004357:Drug Synergism; D004731:Endotoxins; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D008168:Lung / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins; D012772:Shock, Septic / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D013482:Superoxide Dismutase / Q000494:pharmacology*; D015996:Survival Rate
chemical_list: D004731:Endotoxins; D011994:Recombinant Proteins; C044101:endotoxin, Escherichia coli; C039188:taprostene; D011464:Epoprostenol; D013482:Superoxide Dismutase