Oestrogen treatment reduces duration of experimental allergic neuritis in rats and suppresses T cell responses to myelin.
The effects of oestrogen and pregnancy on the disease course of experimental allergic neuritis (EAN) in rats were investigated. Pregnant rats were totally protected from EAN and long term 17-beta-oestradiol treatment significantly shortened the disease duration. Lymph node cells from oestrogen treated rats had a suppressed proliferative response when stimulated with myelin or PPD, both when the response was measured immediately after cell preparation and after 72 h cell culture in vitro. Serum levels of IgG antibodies against myelin, P2 or PPD did not differ between treated and non-treated rats although oestrogen treated rats had significantly higher levels of total IgG. Immunohistochemical stainings of nerve roots showed less intensive invasion of T lymphocytes in the oestrogen treated group while immunoreactivity to both class I and II major histocompatibility complex antigens did not differ in between the groups. These findings show that oestrogen ameliorates EAN and suggest that this effect is mediated by suppression of T cell dependent immunity. Factors in addition to oestrogen may be operative during pregnancy when a total protection from EAN is obtained.
Strigård
K
K
Department of Neurology, Karolinska Institutet, Huddinge Hospital, Stockholm, Sweden.
Holmdahl
R
R
Olsson
T
T
D000818:Animals; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D007142:Immunoglobulin gamma-Chains / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D009186:Myelin Sheath / Q000276:immunology*; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D007142:Immunoglobulin gamma-Chains; D004958:Estradiol