Combined effect of inhaled verapamil and sodium cromoglycate on the airway response to hypertonic saline.
We evaluated the airway effect of inhaled verapamil by comparing it to aerosolized sodium cromoglycate. Airway hyperreactivity was assessed using inhaled hypertonic saline. Sodium cromoglycate prevented bronchoconstriction in all the patients. Inhaled verapamil induced significant bronchial constriction in two patients. The combination of verapamil with sodium cromoglycate was as effective as sodium cromoglycate. It was concluded that inhaled verapamil is not effective in preventing bronchoconstriction induced by hypertonic saline.
Kivity
S
S
Institute of Pulmonary and Allergic Disease, Ichilov Hospital, Tel-Aviv University, Israel.
Yarchovsky
J
J
Greif
J
J
Topilsky
M
M
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects; D012462:Saline Solution, Hypertonic; D014700:Verapamil / Q000008:administration & dosage*
D012462:Saline Solution, Hypertonic; D014700:Verapamil; D004205:Cromolyn Sodium