title: The metabolism of trimipramine in the rat.
abstract: Studies on the metabolism of the tricyclic antidepressant trimipramine, 5-(3-dimethylamino-2-methylpropyl)-10,11-dihydro-5H-dibenz[b,f]azepine, in the rat are described. Many metabolites of trimipramine (TMP) were isolated from rat urine after enzymatic hydrolysis and their structures were identified by a gas chromatographic/mass spectrometric method, before and after appropriate chemical derivatization. Besides unchanged TMP, 20 metabolites were characterized (underivatized, and after acetylation), of which 12 had undergone alicyclic (C10 or C11) oxidation. This is a hitherto unreported metabolic pathway for TMP in the rat.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
authors.forename: R T
authors.initials: RT
authors.lastname: Coutts
authors.forename: M S
authors.initials: MS
authors.lastname: Hussain
authors.forename: R G
authors.initials: RG
authors.lastname: Micetich
authors.forename: M
authors.initials: M
authors.lastname: Daneshtalab
authors.forename: G B
authors.initials: GB
authors.lastname: Baker
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014299:Trimipramine / Q000378:metabolism* / Q000652:urine; D014556:Urine / Q000737:chemistry
chemical_list: D014299:Trimipramine