The effect of DR antigens, race, sex, and peak PRA on estimated median waiting time for a first cadaver kidney transplant.
1. Fifty-six DR phenotypes account for 95% of the population waiting for a transplant and who have received a transplant. There are 15 pairs that account for 46% of the population. Large differences in the distribution of DR phenotypes between the races were observed. 2. There do not appear to be significant differences among the 15 DR phenotypes in the rate of transplantation. There are, however, significant differences in the median waiting time to a first cadaver kidney transplant across the 15 DR phenotypes. 3. Blacks are not being transplanted in proportion to their numbers on the list of those awaiting a transplant. Blacks represent approximately 27% of the population waiting for a transplant, but represent only 22.6% of the population which receives a first cadaver kidney transplant. 4. The estimated median waiting time for Blacks is almost twice that of Whites. When age, peak PRA, DR phenotype, blood type, and sex are controlled, Blacks, when compared to Whites, are still 18% less likely to receive a first cadaver kidney transplant at any point in time.
Kallich
J D
JD
RAND Corporation, Santa Monica, California.
Wyant
T
T
Krushat
M
M
D044383:Black People; D002102:Cadaver; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D010641:Phenotype; D012737:Sex Factors; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014481:United States; D044465:White People; D001741:Black or African American
D006684:HLA-DR Antigens