[Macrophages from healthy adults release TNF-alpha after exposure to Pneumocystis carinii of murine origin. Preliminary study].
The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.
Tamburrini
E
E
Istituto di Clinica delle Malattie Infettive, Università Cattolica del S. Cuore, Roma.
De Luca
A
A
Ventura
G
G
Maiuro
G
G
Siracusano
A
A
Ortona
E
E
Antinori
A
A
D000328:Adult; D000818:Animals; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011010:Pneumocystis / Q000276:immunology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha
Macrofagi di soggetti adulti sani rilasciano TNF-alfa dopo esposizione a Pneumocystis carinii di origine murina. Studio preliminare.