Amyloid beta-protein precursor is associated with extracellular matrix.
The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
Klier
F G
FG
La Jolla Cancer Research Foundation, CA.
Cole
G
G
Stallcup
W
W
Schubert
D
D
D000682:Amyloid / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D002460:Cell Line; D005109:Extracellular Matrix / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D011498:Protein Precursors