title: Usefulness of high-frequency analysis of signal-averaged surface electrocardiograms in acute myocardial infarction before and after coronary thrombolysis for assessing coronary reperfusion.
abstract: The incidence of late potentials on the signal-averaged electrocardiogram before and after coronary thrombolysis was studied in 54 patients with an acute myocardial infarction of less than or equal to 5 hours' duration and with an angiographically documented total occlusion of the infarct-related coronary artery on admission. A significant (p = 0.038) 50% relative reduction in the incidence of late potentials was observed in the group of 35 patients who underwent reperfusion: from 16 of 35 (46%) before to 8 of 35 (23%) at 120 minutes after the start of thrombolytic treatment. No significant reduction was seen in the 19 patients in whom thrombolysis was unsuccessful: from 8 of 19 (42%) before to 7 of 19 (37%) afterward. Despite successful recanalization, late potentials persisted or newly developed after thrombolytic therapy in 8 of 54 patients (15%). It is concluded that successful thrombolysis reduces the incidence of late potentials on the signal-averaged electrocardiogram but that the sensitivity and specificity of this finding are not high enough to allow reliable monitoring of coronary reperfusion at the bedside.
authors.affiliation: Instituto do Coraçao (INCOR), University of Sao Paulo, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Tranchesi
authors.forename: M
authors.initials: M
authors.lastname: Verstraete
authors.forename: F
authors.initials: F
authors.lastname: Van de Werf
authors.forename: C P
authors.initials: CP
authors.lastname: de Albuquerque
authors.forename: B
authors.initials: B
authors.lastname: Caramelli
authors.forename: O C
authors.initials: OC
authors.lastname: Gebara
authors.forename: W I
authors.initials: WI
authors.lastname: Pereira
authors.forename: P
authors.initials: P
authors.lastname: Moffa
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
authors.forename: F
authors.initials: F
authors.lastname: Pileggi
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*; D015425:Myocardial Reperfusion; D011994:Recombinant Proteins / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator