[Newly developed stenocardia: effect of diet with increased amount of polyunsaturated fatty acids of the omega-3 group on blood lipids and apolipoproteins].
The effects of omega-3 polyunsaturated fatty acids (PUSF), a 4-week fish diet--350 g of scomber a day, on the blood lipid-apolipoprotein spectrum were evaluated in 22 patients with primary angina pectoris as compared to 8 control subjects received hospital protein-, fat-, carbohydrate-, and calorie-balanced diet No. 10 differing in omega-3 PUSF content (5 and 0.03 g/day, respectively). The fish diet caused a significant reduction in total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) in patients with hypercholesterolemia, however, the normal cholesterol (under 200 mg/dl) and LDLC (under 130 mg/dl) levels were reached only in a small proportion of the patients. There was a hypotriglyceridemic effect of omega-3 PUSF that was more pronounced at initially high triglyceride concentrations. Heterogeneous changes were found in LDLC levels with the fish diet. i.e. from a great decrease at initially high LDLC levels to a small increase at initially low LDLC in patients with hypertriglyceridemia and low levels of high density lipoproteins. It was concluded that a fish diet should be included into a complex of measures aimed at the secondary prevention of coronary heart disease in patients with primary angina concurrent with hypercholesterolemia (even moderate) and hypertriglyceridemia unassociated with hypoalphacholesterolemia.
Kalinkina
O M
OM
Gratsianskiĭ
N A
NA
Perova
N V
NV
Metel'skaia
V A
VA
Zykova
V P
VP
Olfer'ev
A M
AM
Oganov
R G
RG
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000178:diet therapy*; D000818:Animals; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005399:Fishes; D006801:Humans; D000960:Hypolipidemic Agents; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000097:blood
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Vpervye voznikshaia stenokardiia: vliianie diety s povyshennym soderzhaniem polinenasyshchennykh zhirnykh kislot gruppy omega-3 na lipidy i apolipoproteiny krovi.