title: Coexistent double gammopathy, myeloproliferative disorder, and malignant lymphoma.
abstract: The authors report a patient with coexistent double gammopathy, a Philadelphia chromosome-negative, bcr rearrangement-negative myeloproliferative disease resembling chronic myelocytic leukemia and a malignant lymphoma of B-cell origin. The double gammopathy consisted of IgM (kappa) and IgG (kappa). Peripheral blood, spleen, and marrow lymphocytes had primarily an IgG (kappa) isotype, whereas lymph node lymphocytes had predominantly an IgM (kappa) surface isotype. Increased numbers of marrow lymphocytes stained doubly for both IgM (kappa) and IgG (kappa). The results suggest that doubly isotypic as well as single isotypic lymphocytes contributed to the double gammopathy. Organ localization differed for lymphocytes with different antibody isotypes. This cluster of findings has not been described previously.
authors.affiliation: Department of Medicine, University of Health Sciences, Chicago Medical School, Illinois.
authors.forename: E P
authors.initials: EP
authors.lastname: Ornellas
authors.forename: M M
authors.initials: MM
authors.lastname: LeBeau
authors.forename: M
authors.initials: M
authors.lastname: Venkataraman
authors.forename: W
authors.initials: W
authors.lastname: Thomas
authors.forename: B R
authors.initials: BR
authors.lastname: Amin
authors.forename: C A
authors.initials: CA
authors.lastname: Westbrook
authors.forename: M P
authors.initials: MP
authors.lastname: Westerman
mesh_terms: D000368:Aged; D001402:B-Lymphocytes; D015321:Gene Rearrangement; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000235:genetics / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D008223:Lymphoma / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics / Q000276:immunology; D010677:Philadelphia Chromosome
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains