title: Failure of influenza vaccine to prevent two successive outbreaks of influenza A H1N1 in a school community.
abstract: Forty nine of the 149 boys (33%) at a preparatory school fell ill at the beginning of the autumn term 1986 with symptoms of influenza. One hundred and eighty two of the 470 pupils (39%) in the senior part of the same school had similar symptoms of influenza at the beginning of the spring term 1987. A new variant of influenza A H1N1 virus was isolated from both outbreaks and shown to be antigenically similar to A/Taiwan/1/86. The attack rate among pupils who had previously received trivalent influenza vaccine containing A/Chile/1/83 H1N1 antigen was not significantly different from the rate among those who had never been vaccinated. It is concluded that annual vaccination of all boarding school pupils may be inappropriate.
authors.affiliation: Public Health Laboratory, Chelmsford.
authors.forename: E L
authors.initials: EL
authors.lastname: Teare
authors.forename: J C
authors.initials: JC
authors.lastname: Rawes
authors.forename: P
authors.initials: P
authors.lastname: Chakraverty
authors.forename: N D
authors.initials: ND
authors.lastname: Noah
authors.forename: D
authors.initials: D
authors.lastname: Webster
authors.forename: T
authors.initials: T
authors.lastname: Corcoran
authors.forename: J
authors.initials: J
authors.lastname: Oxford
mesh_terms: D004196:Disease Outbreaks / Q000517:prevention & control*; D004739:England; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D012574:Schools; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines