[Theoretical analysis of the continuous two-stage process of the biosynthesis of a metabolic product].
A mathematical model for continuous biosynthesis of a metabolite in a battery of two apparatuses with ideal agitation is described and analysed. In the first apparatus of the battery it is advisable to maintain a high specific rate of culture growth for continuous accumulation of young active biomass while in the second apparatus a low growth rate is expedient which provides a change in the culture metabolism to biosynthesis of the required product. To make the continuous two-stage process efficient, it is necessary to add an extremely concentrated solution of the nutrients to the second apparatus of the battery. Influence of the oxygen transport velocity on the maximum attainable concentration of the biomass and the process capacity by the required product was studied.
Shnaĭder
L E
LE
Biriukov
V V
VV
Maksimova
E A
EA
Sekoshin
V L
VL
D001431:Bacteriological Techniques / Q000295:instrumentation*; D001692:Biological Transport; D003470:Culture Media; D066298:In Vitro Techniques; D007218:Industrial Microbiology / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D010100:Oxygen / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D010118:Oxytetracycline / Q000096:biosynthesis*; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000254:growth & development / Q000378:metabolism*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors
D003470:Culture Media; D010406:Penicillins; D010100:Oxygen; D010118:Oxytetracycline
Teoreticheskiĭ analiz nepreryvnogo dvukhstadiĭnogo protsessa biosinteza produkta metabolizma.