Fatty acid composition of adipocyte membrane phospholipids and stored triglycerides in infants receiving total parenteral nutrition.
Fatty acid (FA) composition of membrane phospholipids (PL) and stored triglycerides (TG) from adipose tissue was studied in eight infants aged 1 to 4 months receiving total parenteral nutrition (TPN) since birth. During this period, essential fatty acid (EFA) intake consisted exclusively of soybean oil emulsion administered by intravenous route (Intralipid 20%) representing 301 +/- 88 mg/kg/24 hr of linoleic acid and 58 +/- 18 mg/kg/24 hr of alpha-linolenic acid, or 2.3 +/- 0.6% and 0.4 +/- 0.1%, respectively, of total energy intake. The results were compared with those of eight control infants of the same age receiving orally a normal milk diet with an intake of 660 +/- 260 mg/kg/24 hr of linoleic acid and 101 +/- 35 mg/kg/24 hr of alpha-linolenic acid, or 4.5 +/- 0.7% and 0.7 +/- 0.3%, respectively, of total energy intake. Although their EFA intake was significantly lower (p less than 0.01) and administered only parenterally, after 1 to 4 months the infants receiving TPN still had a membrane phospholipid FA pattern of adipose tissue which was not significantly different from that of normal children of the same age. In stored adipocyte TG, the percentage of linoleic acid was significantly lower (p less than 0.01) in infants receiving TPN. This is probably of nutritional importance as at this stage of life the child builds up its stores of EFA. The proportion of the other fatty acids in adipocyte TG was not significantly modified.
Harant
I
I
Groupe d'Etudes en Nutrition Infantile, Chu Purpan, Toulouse, France.
Ghisolfi
J
J
Couvaras
O
O
Garcia
J
J
Vaysse
P
P
Thouvenot
J P
JP
D000273:Adipose Tissue / Q000032:analysis* / Q000166:cytology; D005227:Fatty Acids / Q000032:analysis*; D006801:Humans; D007223:Infant; D008563:Membrane Lipids / Q000032:analysis*; D010289:Parenteral Nutrition, Total; D010743:Phospholipids / Q000032:analysis*; D014280:Triglycerides / Q000032:analysis*
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D014280:Triglycerides