title: Sympathetic secretory response to hypercapnic acidosis in swine.
abstract: We studied the effect of graded acute hypercapnic acidosis (HA) on sympathetic neural activation in 15 juvenile farm swine in vivo. In seven animals with acute HA, plasma norepinephrine (NE) concentration increased progressively from 189 +/- 34 to 483 +/- 80 pg/ml (P less than 0.04) as arterial CO2 partial pressure (PaCO2) increased in steps from 40 to 80 Torr (pH 7.17 +/- 0.01). Plasma epinephrine (EPI) concentration increased from 30 +/- 15 to 125 +/- 66 pg/ml (P = NS) over the same change in PaCO2. At PaCO2 of 110 Torr, plasma NE increased 3.4-fold above maximal basal concentrations; plasma EPI was 1.8-fold greater than basal under the same conditions. With HA, systemic vascular resistance (SVR) decreased from 1,748 +/- 110 to 1,392 +/- 145 dyn.s.cm-5 (P less than 0.0002), cardiac output (CO) increased from 3.4 +/- 0.3 to 4.3 +/- 0.3 l/min (P less than 0.01), and heart rate (HR) increased from 117 +/- 11 to 154 +/- 17 beats/min (P less than 0.03). To demonstrate that catecholamine secretion was related directly to acidosis caused by an increase in PaCO2, HCO3- was infused in eight other swine to buffer extracellular acute HA (pH 7.37 +/- 0.01 at PaCO2 of 80 Torr). Buffering attenuated the increase in plasma NE, which remained within the normal range at PaCO2 of 80 Torr. The decrease in SVR and increases in CO and HR also were also attenuated by HCO3- buffering of HA. We demonstrate the effects of graded acute HA on endogenous secretion of catecholamine and on the associated hemodynamic responses in swine.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Chicago, Illinois 60637.
authors.forename: J D
authors.initials: JD
authors.lastname: Brofman
authors.forename: A R
authors.initials: AR
authors.lastname: Leff
authors.forename: N M
authors.initials: NM
authors.lastname: Munoz
authors.forename: C
authors.initials: C
authors.lastname: Kirchhoff
authors.forename: S R
authors.initials: SR
authors.lastname: White
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D013552:Swine; D013564:Sympathetic Nervous System / Q000378:metabolism*
chemical_list: D002245:Carbon Dioxide; D009638:Norepinephrine; D004837:Epinephrine