Proximal gastric vagotomy with carbon dioxide laser: experimental studies in animals.
Proximal gastric vagotomy has been widely used as a surgical treatment for peptic ulcer disease. However, it is technically complex and time-consuming. Moreover, it may cause circulatory problems in the gastric mucosa. We have reported a new method of blood flow-preserving vagotomy with a carbon dioxide laser (CO2 laser vagotomy) developed in our laboratory. To assess its efficacy, we used cysteamine-induced ulcer and measured gastric mucosal blood flow in rats. The incidence of cysteamine-induced ulcer formation was reduced significantly in the group that underwent CO2 laser vagotomy compared with a group treated with proximal gastric vagotomy. Gastric mucosal blood flow was significantly better in the CO2 laser vagotomy group. Long-term follow-up of acid reduction was evaluated in dogs by the pentagastrin-stimulation test. Acid reduction in dogs was satisfactory during the 12 months of this study. CO2 laser vagotomy is a new, easy, time-saving, and circulatory-preserving technique for peptic ulcer disease.
Kadota
T
T
First Surgical Department, National Defense Medical College, Saitama, Japan.
Mimura
K
K
Kanabe
S
S
Ohsaki
Y
Y
Tamakuma
S
S
D000818:Animals; D002245:Carbon Dioxide; D003543:Cysteamine; D004285:Dogs; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000601:surgery; D005753:Gastric Mucosa / Q000098:blood supply; D053685:Laser Therapy; D008297:Male; D010418:Pentagastrin; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D014629:Vagotomy, Proximal Gastric
D002245:Carbon Dioxide; D003543:Cysteamine; D010418:Pentagastrin