Prostacyclin versus thromboxane metabolite excretion: changes in pregnancy and labor.
Urinary TXB2 and 6-keto-PGF1 alpha were measured by high pressure liquid chromatography combined with radioimmunoassay, in order to determine whether or not urinary excretion of 6-keto-PGF1 alpha and TXB2 followed a same pattern in pregnancy and labor. The excretion of 6-keto-PGF1 alpha was higher than that of TXB2 in both non-pregnant and pregnant women, but the ratio between them increased in pregnancy. The urinary excretion of both 6-keto-PGF1 alpha and TXB2 excretion was significantly increased (p less than 0.001) in pregnancy. Labor was associated with a much wider inter-individual variation in the excretion of 6-keto-PGF1 alpha and TXB2 than observed in pregnancy and in non-pregnant women. Also, the ratio between the two compounds varied more in labor than in pregnancy. The data indicate that the urinary levels of these two compounds do not follow a single well-determined pattern in pregnancy and labor.
Noort
W A
WA
Department of Obstetrics, Leiden University Hospital, The Netherlands.
Keirse
M J
MJ
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D011464:Epoprostenol / Q000652:urine*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000652:urine*; D011247:Pregnancy / Q000652:urine*; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000652:urine; D013931:Thromboxanes / Q000652:urine*
D013931:Thromboxanes; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol