[Synthesis and antitumor activity of new analogs of anthracycline antibiotics modified by aglycon].
Anthracycline antibiotics widely used, along with their semisynthetic analogues, in human cancer chemotherapy, are O-glycosides having as aglycon 7,8,9,10-tetrahydronaphtacenequinone-5,10-with some hydroxy groups, a side chain at C-9 and sugar(s) residues, usually at C-7. The review includes the most important studies on the chemical modification of the aglycon moiety of daunorubicin, doxorubicin and carminomycin during last ten years. Activity of the compounds on experimental tumours is described and their structure-activity relationship is discussed.
Olsuf'eva
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D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents
Sintez i protivopukholevaia aktivnost' novykh analogov antratsiklinovykh antiviotikov, modifitsirovannykh po aglikonu.