Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts.
Although treatment of human macrophages or fibroblasts with human gamma interferon results in the inhibition of intracellular Toxoplasma gondii, murine gamma interferon stimulated only murine macrophages, not murine fibroblasts, to inhibit T. gondii. This species difference may be important in understanding the control of acute and chronic toxoplasmosis.
Schwartzman
J D
JD
Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908.
Gonias
S L
SL
Pfefferkorn
E R
ER
D000818:Animals; D005347:Fibroblasts / Q000469:parasitology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D013045:Species Specificity; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development; D014366:Tryptophan Oxygenase / Q000096:biosynthesis
D007371:Interferon-gamma; D014366:Tryptophan Oxygenase