Interaction of thiourea with rat lung protein.
Administration of the pulmonary edemagenic agent [14C]Thiourea [( 14C]TU) to adult rats results in heterogeneous binding to lung protein. Indirect evidence suggests that TU may be binding to the amino acid cysteine, possibly via the SH moiety. The nature of the adduct is not known, but appears to involve one major and several minor species.
Hollinger
M A
MA
Department of Pharmacology, School of Medicine, School of Veterinary Medicine University of California, Davis 95616.
Giri
S N
SN
D000818:Animals; D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000502:physiology; D008168:Lung / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D013890:Thiourea / Q000378:metabolism*
D005978:Glutathione; D013890:Thiourea; D003545:Cysteine