Hemodynamic response to pumpless extracorporeal membrane oxygenation.
Respiratory support by means of arteriovenous extracorporeal membrane oxygenation driven by systemic arterial pressure, in contrast to pump-driven venoarterial extracorporeal membrane oxygenation, is attractive because of its simplicity and lack of trauma to formed blood elements. Although arteriovenous extracorporeal membrane oxygenation has been shown to improve arterial blood gases, useful levels of arteriovenous extracorporeal membrane oxygenation shunt flow may exert detrimental effects on systemic and pulmonary hemodynamics. Therefore the hemodynamic consequences of arteriovenous extracorporeal membrane oxygenation were studied in 11 dogs that were anesthetized, heparinized, and their lungs mechanically ventilated (FIO2 = 0.21) before and after induction of oleic acid pulmonary edema. The data indicate that arteriovenous extracorporeal membrane oxygenation shunt flows adequate to improve arterial blood gases resulted in significant changes in peripheral vascular resistance (-46%; p less than 0.05), systemic arterial blood pressure (-20%; p less than 0.05), and cardiac output (+110%; p less than 0.05). Dopamine infusion (5 micrograms/kg/min) proved to be more effective than volume expansion (15 ml/kg) in maintaining cardiac output, arterial blood pressure, and arterial blood gases. We conclude that pumpless arteriovenous extracorporeal membrane oxygenation, at flow rates adequate for respiratory support, can adversely alter systemic hemodynamics. However, these effects can be beneficially modulated by a moderate dose of inotropic medication.
Chapman
J
J
Division of Cardiothoracic Surgery, Case Western Reserve University, Cleveland, Ohio.
Adams
M
M
Geha
A S
AS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D019301:Oleic Acid; D009829:Oleic Acids; D010100:Oxygen / Q000097:blood; D011654:Pulmonary Edema / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy; D011659:Pulmonary Gas Exchange; D014655:Vascular Resistance
D009829:Oleic Acids; D002245:Carbon Dioxide; D019301:Oleic Acid; D010100:Oxygen; D004298:Dopamine