Cyclodextrin chiral stationary phases for liquid chromatographic separations of drug stereoisomers.
Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided.
Berthod
A
A
Department of Chemistry, University of Missouri-Rolla 65401.
Jin
H L
HL
Beesley
T E
TE
Duncan
J D
JD
Armstrong
D W
DW
D002853:Chromatography, Liquid; D003505:Cyclodextrins; D013237:Stereoisomerism
D003505:Cyclodextrins