[An electrophysiological analysis of the action of an antioxidant of the 3-hydroxypyridine class on the cerebral epileptic activity in rats with a cobalt-induced focus].
In experiments on albino male rats with chronically implanted electrodes and an epileptogenic focus in the cortical sensomotor region it was shown that a derivative of 3-hydroxy-pyridine (2-ethyl-6-methyl-3-hydroxypyridine) possesses the pronounced antiepileptic effect. The effect of the agent is related to the functional state of the epileptic system whose resistance to pharmacotherapy depends on the power of the determinant focus.
Aliev
A N
AN
Nerobkova
L N
LN
Voronina
T A
TA
Guseĭnov
D Ia
DIa
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002908:Chronic Disease; D003035:Cobalt; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000503:physiopathology; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D010847:Picolines; D003035:Cobalt; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Elektrofiziologicheskiĭ analiz deĭstviia antioksidanta iz klassa 3-oksipiridina na épilepticheskuiu aktivnost' mozga krys s kobal'tovym ochagom.