title: Meningeal dissemination of retinoblastoma: CT findings in eight patients.
abstract: Thirty-seven patients with retinoblastoma were evaluated prospectively by clinical examination, lumbar puncture, and CT. Eight (22%) of the 37 were found to have meningeal dissemination. The tumor was bilateral in three patients. Two cases showed no CT signs of local recurrence. Headache, nausea/vomiting, and restlessness were the most common symptoms. CT scans in these patients showed diffuse meningeal contrast enhancement, nodular masses, ependymal-subependymal enhancement, and ventricular dilatation. Our series of eight patients with meningeal spread illustrates a considerable range of dissemination patterns referable to retinoblastoma. One case illustrated the CT finding of multiple epidural metastases.
authors.affiliation: Department of Neuroimaging, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina.
authors.forename: F J
authors.initials: FJ
authors.lastname: Meli
authors.forename: C A
authors.initials: CA
authors.lastname: Boccaleri
authors.forename: J
authors.initials: J
authors.lastname: Manzitti
authors.forename: P
authors.initials: P
authors.lastname: Lylyk
mesh_terms: D002648:Child; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed