[Clinical study of lung injury in acute pancreatitis].
Lung injury is a common and severe complication in acute pancreatitis. The pathogenesis of which has not been completely understood. To explore the mechanism of lung injury, ST and FFA and PLA in bronchoalveolar perfusate, FFA and PLA in blood were measured; clinical symptoms and chest film were analysed; blood gas analysis was performed. The results indicated that lung injury mostly occurs in ABNP and less in AEP. Pulmonary edema and atelectasis are essential changes of lung injury. It is believed that FFA is an important factor responsible for pulmonary edema. PLA, which plays the most important role in lung injury, not only results in atelectasis by degradating the SA in alveolar, but also induces pulmonary edema. The main reason for the increase of ST is the degradation of SA in alveolar. The levels of FFA and PLA in the blood may indicate the severity of acute pancreatitis. However, it remains unknown whether the synthesis of SA in patient with acute pancreatitis is inhibited.
Liao
C X
CX
Southwest Hospital, Third Military Medical University, Chongqing.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000378:metabolism; D010741:Phospholipases A / Q000032:analysis; D001261:Pulmonary Atelectasis / Q000209:etiology*; D011654:Pulmonary Edema / Q000209:etiology*; D011663:Pulmonary Surfactants / Q000032:analysis
D005230:Fatty Acids, Nonesterified; D011663:Pulmonary Surfactants; D010741:Phospholipases A