Lack of genotoxic activity of metronidazole and P1 derivative in two eukaryotic tests.
Metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole] and P1 derivative [1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole] were investigated for their genotoxic activity in two eukaryotic tests: mitotic recombination in yeast and micronucleus test in mice. Both compounds showed no genotoxicity in these eukaryotic assays contrary to their well-documented mutagenic activity in microbial short-term tests.
Konopacka
M
M
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Grzybowska
E
E
Michalska
J
J
D000818:Animals; D005057:Eukaryotic Cells / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects*; D009152:Mutagenicity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D008795:Metronidazole; C069502:1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole