title: Protracted anuria due to active vasoconstriction in primary or secondary malignant hypertension.
abstract: Anuria complicated the malignant phase of hypertension in twelve patients (ten males and two females). Five were black; five had primary hypertension; one had HBs virus angiitis; the six remaining cases suffered from previously documented renal disease, including two with Berger's disease. Renal angiography showed interruption of renal blood flow as far as the main branches of the renal artery and/or a false impression of 'cortical necrosis' and of 'renal infarcts'. In contrast, renal biopsy did not show irreversible vascular damage. Thus, anuria was mainly functional and due to active renal vasoconstriction. This was confirmed by the subsequent course; diuresis resumed after 1 week to 24 months of dialysis. Repeat angiography in six cases showed recovery of renal circulation and disappearance of 'cortical infarcts', even when plasma renin activity remained elevated and hypertension was not controlled. In one case captopril induced a new reversible episode of anuria. These observations suggest that active vasoconstriction with prolonged anuria might be due to some vasoconstrictive substance other than angiotensin II.
authors.affiliation: Service de Néphrologie, Hôpital Avicenne, Bobigny, France.
authors.forename: A
authors.initials: A
authors.lastname: Meyrier
authors.forename: L
authors.initials: L
authors.lastname: Becquemont
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: J P
authors.initials: JP
authors.lastname: Laaban
mesh_terms: D000328:Adult; D001002:Anuria / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D004231:Diuresis; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006974:Hypertension, Malignant / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D006435:Renal Dialysis
chemical_list: D005665:Furosemide