[Experimental emphysema following intravenous injection of trypsin].
The injection of trypsin provokes a decrease of the circulating antiproteases. Its effect on an elastase-induced emphysema is negligible. Paradoxically, emphysema is quantitatively demonstrated in rats treated with trypsin alone: an influx of polymorphonuclear leucocytes into the lung is observed during the acute phase of experiment.
Reichart
E
E
Unité de Recherche, I.N.S.E.R.M. U. n. 14, Vandoeuvre-les-Nancy.
Plenat
F
F
Boerkmann
P
P
Vignaud
J M
JM
D000818:Animals; D004646:Emphysema / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D007275:Injections, Intravenous; D008168:Lung / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010196:Pancreatic Elastase / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000008:administration & dosage / Q000494:pharmacology*
D010196:Pancreatic Elastase; D014357:Trypsin
Emphysème expérimental consécutif à une injection intraveineuse de trypsine.