title: Tissue plasminogen activator and penetrating keratoplasty.
abstract: We report a patient who developed severe intraocular fibrin formation following penetrating keratoplasty and vitrectomy surgery. The fibrin response worsened despite aggressive treatment with topical steroids. On the second postoperative day, 25 micrograms of intracameral tissue plasminogen activator was administered, resulting in rapid resolution of the fibrin response. The graft remained clear. We believe tissue plasminogen activator may be useful in selected cases of severe, recalcitrant postkeratoplasy fibrin formation.
authors.affiliation: Department of Ophthalmology, William Beaumont Hospital, Royal Oak, Mich.
authors.forename: D G
authors.initials: DG
authors.lastname: Heidemann
authors.forename: G A
authors.initials: GA
authors.lastname: Williams
authors.forename: M S
authors.initials: MS
authors.lastname: Blumenkranz
mesh_terms: D005128:Eye Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008875:Middle Aged; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014821:Vitrectomy / Q000009:adverse effects*
chemical_list: D005337:Fibrin; D010959:Tissue Plasminogen Activator