Possible protein binding displacement interaction between glibenclamide and metolazone.
The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
George
S
S
Department of Clinical Pharmacology, Glenfield General Hospital, Leicester, UK.
McBurney
A
A
Cole
A
A
D000368:Aged; D001667:Binding, Competitive; D001798:Blood Proteins / Q000378:metabolism*; D003956:Dialysis; D004232:Diuretics / Q000378:metabolism*; D005905:Glyburide / Q000378:metabolism* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008788:Metolazone / Q000378:metabolism* / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects
D001798:Blood Proteins; D004232:Diuretics; D005905:Glyburide; D008788:Metolazone