title: The use of ketanserin for postoperative hypertension after abdominal surgery.
abstract: Eighteen adult patients who developed hypertension (systolic blood pressure greater than 160 mmHg, diastolic blood pressure greater than 90 mmHg or both) at the early recovery period after major abdominal surgery were included in the study. Following intravenous injection of 10 mg ketanserin, eleven out of eighteen patients (61%) had their systolic or diastolic blood pressure fell below the target mark (160 mmHg and 90 mmHg), and the decrease was statistically significant (p less than 0.01 up to 120 min). There was no statistically significant change in heart rate. Four patients (22%) responded to 20 mg of ketanserin. Three patients (17%) did not have significant decrease of the blood pressure after 20 mg of ketanserin and they received other antihypertensives instead. No severe hypotensive episode was noted. We concluded that ketanserin is a moderate, rapid-onset and safe antihypertensive agent in treating postoperative hypertension following major abdominal surgery.
authors.affiliation: Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: C C
authors.initials: CC
authors.lastname: Shu
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
authors.forename: T Y
authors.initials: TY
authors.lastname: Lee
authors.forename: P W
authors.initials: PW
authors.lastname: Lui
authors.forename: Y P
authors.initials: YP
authors.lastname: Daiy
authors.forename: J Y
authors.initials: JY
authors.lastname: Ma
authors.forename: L H
authors.initials: LH
authors.lastname: Chow
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D011985:Receptors, Serotonin / Q000187:drug effects
chemical_list: D011985:Receptors, Serotonin; D007650:Ketanserin