Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms.
The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.
Jensen
E T
ET
Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.
Kharazmi
A
A
Lam
K
K
Costerton
J W
JW
Høiby
N
N
D000464:Alginates / Q000032:analysis; D001422:Bacterial Adhesion / Q000276:immunology*; D002455:Cell Division; D015169:Colony Count, Microbial; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D010101:Oxygen Consumption; D011550:Pseudomonas aeruginosa / Q000276:immunology*
D000464:Alginates