Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2.
Hb Davenport is a new, stable alpha chain variant, that was detected in two members of a Caucasian family living in Iowa. Hematological data were within normal limits. It is characterized by an Asn----His replacement at position alpha 78. Mild acidic hydrolysis of the large alpha T-9 peptide, separation of the resulting fragments by reversed phase high performance liquid chromatography, and sequence analysis of a few of these peptides greatly facilitated the identification of this substitution.
Wilson
J B
JB
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Webber
B B
BB
Plaseska
D
D
de Alarcon
P A
PA
McMillan
S K
SK
Huisman
T H
TH
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001216:Asparagine / Q000235:genetics; D005260:Female; D006455:Hemoglobins, Abnormal / Q000737:chemistry* / Q000235:genetics; D006639:Histidine / Q000235:genetics; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D009154:Mutation
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; C070263:hemoglobin Davenport; D006639:Histidine; D001216:Asparagine