title: [Changes in the hemostasis system during long-term intravenous administration of nitroglycerin in the acute period of myocardial infarct].
abstract: Twenty seven patients were examined in the first hours of the onset of myocardial infarction for the hemostatic systems during a long-term intravenous administration of nitroglycerin (N). They were compared with 24 patients from a control group. N was found to reduce the signs of blood hypercoagulation, decrease platelet aggregation, increase fibrinolytic activity, and elevate antithrombin III levels. Hemostatic alterations were related to a hemodynamic response to nitroglycerin. Positive shifts in the hemostatic system were the most evident in the patients who exhibited higher cardiac output and lower signs of heart failure. In the patients without signs of heart failure, N deteriorated hemodynamic parameters, aggravated hypercoagulation and inhibited blood fibrinolytic activity.
authors.forename: D K
authors.initials: DK
authors.lastname: Broun
authors.forename: V K
authors.initials: VK
authors.lastname: Lazutkin
authors.forename: S V
authors.initials: SV
authors.lastname: Kuznetsov
authors.forename: N T
authors.initials: NT
authors.lastname: Samorukova
authors.forename: N K
authors.initials: NK
authors.lastname: Broun
mesh_terms: D001780:Blood Coagulation Tests; D006439:Hemodynamics / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D005996:Nitroglycerin
vernacular_title: Izmeneniia sistemy gemostaza pri dlitel'nom vnutrivennom vvedenii nitroglitserina v ostrom periode infarkta miokarda.