Intermediate filaments in DMBA-induced mammary adenocarcinomas in rats.
Experimental DMBA (7,12-dimethylbenzanthracene)-induced mammary tumours in rats were studied. Microscopic examination revealed a high rate of adenocarcinomas (95.3% in 148 mammary tumours studied). An immunohistochemical study of cytoskeleton intermediate filaments (I.F.) showed cytokeratins in neoplastic epithelial cells; myoepithelial cells expressed cytokeratins, vimentin and desmin. Finally we propose the immunocytochemical localization of desmin as a useful method to recognize myoepithelial proliferation areas in mammary tumours.
Peña
L
L
Department of Animal Pathology II, Veterinary School, Complutense University of Madrid, Spain.
Flores
J M
JM
Castaño
M
M
Gonzalez
M
M
D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007382:Intermediate Filaments / Q000737:chemistry*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D007381:Intermediate Filament Proteins