title: [Initial therapy of acute unilateral epididymitis using ofloxacin. I. Clinical and microbiological findings].
abstract: In a prospective study, 70 men suffering from uncomplicated acute unilateral epididymitis were treated initially with 2 x 200 mg ofloxacin p.o. per day for 14 days. Patients were reexamined at the end of therapy and again after 6 and 12 weeks. Patients were retreated when the pathogens had not been eliminated. Aetiologically epididymitis was caused in one-third of cases each by C. trachomatis (n = 20) and common urinary tract pathogens (n = 20); in the remaining one-third we found N. gonorrhoeae (n = 1). U. urealyticum (n = 3), or no pathogens (n = 26). At the first check-up examination, in 64/70 patients no pathogens were found. Relevant bacteria were still detected in 6 patients: C. trachomatis in 5 and E. aerogenes in 1. After 12 weeks, infection still persisted in 3 patients (E. coli, P. aeruginosa, enterococci). In vitro the microorganisms were invariably sensitive to ofloxacin. Due to abscess formation, surgical intervention became necessary in 6 patients. In 3 of these cases the causative agent was C. trachomatis. Regardless of the aetiology, after 12 weeks, in 20% of our patients the epididymis was still infiltrated and 14% complained of persistent symptoms.
authors.affiliation: Urologische Klinik, Justus Liebig Universität Giessen.
authors.forename: W
authors.initials: W
authors.lastname: Weidner
authors.forename: C
authors.initials: C
authors.lastname: Garbe
authors.forename: L
authors.initials: L
authors.lastname: Weissbach
authors.forename: J
authors.initials: J
authors.lastname: Harbrecht
authors.forename: K
authors.initials: K
authors.lastname: Kleinschmidt
authors.forename: H G
authors.initials: HG
authors.lastname: Schiefer
authors.forename: H J
authors.initials: HJ
authors.lastname: Friedrich
mesh_terms: D000208:Acute Disease; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001437:Bacteriuria / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D004823:Epididymitis / Q000188:drug therapy* / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D015242:Ofloxacin / Q000627:therapeutic use*; D011446:Prospective Studies; D014509:Ureaplasma / Q000302:isolation & purification
chemical_list: D015242:Ofloxacin
vernacular_title: Initiale Therapie der akuten einseitigen Epididymitis mit Ofloxacin. I. Klinische und mikrobiologische Befunde.