The effect of perivascular denervation on endothelium-dependent relaxation to acetylcholine.
We have examined the effect of perivascular denervation on the ability of acetylcholine to produce endothelium-dependent relaxation in the isolated perfused mesenteric arterial bed. Treatment with capsaicin prevented the development of substance P and calcitonin gene-related peptide containing perivascular nerve fibres. Treatment with 6-hydroxydopamine prevented the development of catecholaminergic perivascular nerve fibres. In the arterial beds from capsaicin treated rats there was a depression of the ability of Acetylcholine to produce endothelium dependent relaxation. No change in endothelium-dependent relaxation to ACh was found in 6-hydroxydopamine treated rats.
Miller
M E
ME
Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Scott
T M
TM
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D003714:Denervation; D004730:Endothelium, Vascular / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology; D066298:In Vitro Techniques; D008638:Mesenteric Arteries / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D009569:Nitric Oxide / Q000096:biosynthesis; D016627:Oxidopamine; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D006892:Hydroxydopamines; D009569:Nitric Oxide; D016627:Oxidopamine; D000109:Acetylcholine; D002211:Capsaicin