title: The reactive serine residue of epidermolytic toxin A.
abstract: Comparison of amino acid sequence data suggested that there may be a functional relationship between the staphylococcal epidermolytic toxins and V8 proteinase. The hypothesis was tested by treating epidermolytic toxin with di-isopropyl phosphorofluoridate, which bound specifically at serine-195, the homologue of the active-site serine residue of V8 proteinase.
authors.affiliation: Department of Biochemistry, Trinity College, Dublin, Ireland.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bailey
authors.forename: T P
authors.initials: TP
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D001427:Bacterial Toxins; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D005083:Exfoliatins; D007531:Isoflurophate; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D012689:Sequence Homology, Nucleic Acid; D012694:Serine; D012697:Serine Endopeptidases; D013211:Staphylococcus aureus / Q000378:metabolism*; D014357:Trypsin
chemical_list: D001427:Bacterial Toxins; D005083:Exfoliatins; D010446:Peptide Fragments; D007531:Isoflurophate; D012694:Serine; D012697:Serine Endopeptidases; C028344:glutamyl endopeptidase; D014357:Trypsin