[Obsessive-compulsive symptoms associated with panic disorder. Predictive factor of a good therapeutic response to fluvoxamine].
In a sample of 35 patients with a diagnosis of panic disorder or agoraphobia with panic attacks according DSM III criteria, the authors found 8 patients (23%) with obsessive compulsive symptoms. This subgroup and 7 patients without obsessive compulsive symptoms were treated with fluvoxamine, a selective serotonin uptake inhibitor in an 8 weeks open study (2 weeks wash out, 6 weeks treatment). At the end of the study, a dramatic reduction of anxiety was found in different rating scales. Ten patients improved and no panic attack was noted: 7 in the group with obsessive compulsive symptoms (N = 8) and 3 in the group without obsessive compulsive symptoms (N = 7). Interest of fluvoxamine in panic patients with obsessive compulsive symptoms who do not respond to common antipanic medication is suggested. Controlled studies are necessary to confirm these first results.
Servant
D
D
Unité de Psychopathologie et Alcoologie, C.H.U. de Lille, Hôpital de la Charité.
Bailly
D
D
Le Seac'h
H
H
Parquet
P J
PJ
D000328:Adult; D000379:Agoraphobia / Q000150:complications / Q000188:drug therapy*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D016666:Fluvoxamine; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy*; D010091:Oximes / Q000627:therapeutic use*; D010200:Panic / Q000187:drug effects*
D000928:Antidepressive Agents; D010091:Oximes; D016666:Fluvoxamine
Symptômes obsessionnels-compulsifs associés au trouble panique. Facteur prédictif d'une bonne réponse thérapeutique à la fluvoxamine.