Tubular sodium handling in cirrhotic patients with ascites as analysed by the renal lithium clearance method.
The proximal and distal sodium reabsorption were calculated from lithium clearance in 21 healthy controls and 24 cirrhotic patients with ascites after 4 days under a sodium-restricted diet. The values of fractional lithium clearance were lower in patients than in controls (7.37 +/- 0.87 vs. 18.13 +/- 1.76%, P less than 0.001). Fractional proximal sodium reabsorption was increased in patients compared with controls (92.8 +/- 1.1 vs. 81.8 +/- 1.7%, P less than 0.001). No differences were found in fractional distal sodium reabsorption between controls and patients (96.9 +/- 0.8 vs. 98.6 +/- 0.1%). When patients were separated into two subgroups according to their sodium balance, it was found that fractional distal sodium reabsorption was increased in patients whose balance remained positive, compared with patients on a negative sodium balance (98.99 +/- 0.26 vs. 94.11 +/- 1.50%, P less than 0.05). In addition, the natriuretic response to a specific dose of spironolactone was higher in patients on positive sodium balance compared with patients on negative sodium balance (per cent increase in natriuresis after spironolactone 300 mg day-1: 355.24 +/- 73.98 vs. 84.21 +/- 15.8%, P less than 0.01). We conclude that proximal sodium reabsorption is increased in cirrhotics with ascites. In addition, distal sodium reabsorption is enhanced only in those patients which exhibit avid sodium retention.
Diez
J
J
Department of Medicine, School of Medicine, University of Zaragoza, Spain.
Simon
M A
MA
Anton
F
F
Indart
F J
FJ
Prieto
J
J
D000328:Adult; D000368:Aged; D001201:Ascites / Q000150:complications / Q000378:metabolism; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008094:Lithium / Q000493:pharmacokinetics; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009318:Natriuresis; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage
D012982:Sodium, Dietary; D008094:Lithium; D012964:Sodium