IgD-receptor-positive human T lymphocytes. I. Modulation of receptor expression by oligomeric IgD and lymphokines.
Studies with human myeloma-derived IgD have demonstrated the existence of IgD-R on peripheral blood T cells. These receptors, which are detected by rosetting with IgD-coated ox E (IgD-rosette-forming cells), are competitively inhibited by IgD, but not by IgM or IgG. Similar results were obtained with human T cell clones and T hybridomas derived from such clones either by rosetting assays or by staining with biotinylated-IgD. In agreement with studies of murine IgD-R+ cells, human IgD-R can be up-regulated by exposure of peripheral blood T cells, T cell clones, and hybridomas derived from such clones, to oligomeric IgD, but not monomeric IgD. Human IgD-R can also be induced by IL-2, IL-4, and IFN-gamma. In contrast with studies of murine IgD-R, which are expressed primarily by CD4+ cells, phenotyping studies show that both the CD4+ and CD8+ human T cell subsets are capable of expressing IgD-R.
Coico
R F
RF
Department of Microbiology, City University of New York Medical School, NY 10031.
Tamma
S L
SL
Bessler
M
M
Wei
C F
CF
Thorbecke
G J
GJ
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D002460:Cell Line; D006801:Humans; D007072:Immunoglobulin D / Q000502:physiology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology*; D010641:Phenotype; D011961:Receptors, Fc; D011971:Receptors, Immunologic / Q000032:analysis*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D015854:Up-Regulation
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D007072:Immunoglobulin D; D008222:Lymphokines; D011961:Receptors, Fc; D011971:Receptors, Immunologic; C050855:immunoglobulin D receptor