Immunological classification of 31 multiple myeloma patients.
Thirty-one multiple myeloma patients were classified chiefly by heavy and light chain detection of myeloma protein (M protein). The results were as follows: 19 out of the 31 cases belonged to the IgG class, including the following subclasses--IgG1-lambda, 7; IgG1-k, 5; IgG3-lambda, 1; IgG3-k, 2; double M myeloma, 2 (IgG3-lambda + IgG2-k, IgG1-lambda + IgG4-lambda); IgG-lambda, 1; and IgG1-k 1. Seven cases were light chain diseases, of which 4 belonged to lambda type, 2 were k, and one was a double light chain disease. Five cases belonged to the IgA class (IgA-lambda, 3; IgA-k, 2). We found no correlation between electrophoretic mobility and the antigenicity of M protein even within subclasses, and the highly concentrated BJP in urine had a tendency to form light chain polymers, possibly along different polymerization pathways.
Qiu
W X
WX
Fujian Medical College, Fuzhou.
Huang
N H
NH
Wu
G H
GH
D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D009101:Multiple Myeloma / Q000145:classification* / Q000276:immunology; D009194:Myeloma Proteins / Q000032:analysis
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins