Actions of endothelin-1 on prostaglandin production by gestational tissues.
Endothelin-1 (10(-11)M-10(-7)M) was incubated with human umbilical vein endothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F2 alpha production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition.
Mitchell
M D
MD
Department of Obstetrics and Gynecology, University of Utah Medical Center, Salt Lake City.
Romero
R J
RJ
Lepera
R
R
Rittenhouse
L
L
Edwin
S S
SS
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000650:Amnion / Q000187:drug effects / Q000378:metabolism; D003656:Decidua / Q000187:drug effects / Q000378:metabolism; D015232:Dinoprostone / Q000096:biosynthesis; D016232:Endothelins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D014471:Umbilical Veins / Q000187:drug effects / Q000378:metabolism
D016232:Endothelins; D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone