Role of somatic mutation in atherosclerosis.
Thus, plaque DNAs from two widely different classes of organisms exhibit similar molecular alterations, which are comparable to those previously described for a number of tumor DNAs. These findings represent the first direct demonstration that mutational events may be critical in the etiology of arteriosclerotic plaques.
Penn
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Department of Environmental Medicine, New York University Medical Center, NY 10016.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000235:genetics*; D002273:Carcinogens; D002999:Clone Cells / Q000473:pathology; D006801:Humans; D009130:Muscle, Smooth / Q000473:pathology; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics; D014162:Transfection; D014780:Viruses / Q000472:pathogenicity
D002273:Carcinogens