The central inhibitory effect of interleukin-1 on gastric acid secretion.
The effect of interleukin-1 (IL-1) on gastric secretory functions was examined in pylorus-ligated conscious rats. Intracisternal (i.c.) injection of IL-1 beta (1-100 ng) induced dose-related, long-lasting inhibition of gastric acid output, which was due to the reductions of both the amount and the acid concentration of the gastric juice. A much higher dose of IL-1 alpha was required to achieve identical effects on gastric acid secretion when it was given by intravenous routes. The i.c. injection of IL-1 alpha also had an inhibition of gastric secretion. This inhibitory effect of i.c. applied IL-1 beta on gastric acid secretion was completely abolished in indomethacin-pretreated animals but not in reserpine-pretreated ones. These results suggest that IL-1 may have an inhibitory action on the regulation of gastric secretory functions by its central action which is dependent on the eicosanoid metabolism.
Ishikawa
T
T
Division of Psychosomatic Research, National Center of Neurology and Psychiatry, Ichikawa Chiba, Japan.
Nagata
S
S
Ago
Y
Y
Takahashi
K
K
Karibe
M
M
D000818:Animals; D001921:Brain / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007267:Injections; D007375:Interleukin-1 / Q000494:pharmacology*; D008026:Ligation; D008297:Male; D011708:Pylorus; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology
D007375:Interleukin-1; D012110:Reserpine; D007213:Indomethacin