Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum.
Passively transferred immune serum provided significantly greater protection to BALB/c mice against attenuated Brucella abortus 19 than against virulent strain 2308, whether serum donors had been infected with strain 19 or 2308. In contrast, immune T cells conferred better protection upon recipients challenged with the homologous strain of B. abortus. It is hypothesized that strain 2308, but not strain 19, can survive in macrophages after opsonization and that epitopes which induce protective cell-mediated immunity may differ between strains 19 and 2308.
Araya
L N
LN
Department of Veterinary Microbiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Winter
A J
AJ
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage; D002003:Brucella abortus / Q000276:immunology; D002006:Brucellosis / Q000517:prevention & control*; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology
D000907:Antibodies, Bacterial