title: In vitro activities of seven quinolone derivatives against Neisseria gonorrhoeae.
abstract: The in vitro activities of ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 10 penicillinase-producing N. gonorrhoeae strains (PPNG's), 10 non-PPNG's, 10 non-penicillinase-producing penicillin-resistant chromosomally mediated N. gonorrhoeae strains (CMRNG's) 3 N. gonorrhoeae strains with a decreased sensitivity against quinolones compounds and one tetracycline-resistant penicillinase-producing N. gonorrhoeae (TRNG/PPNG), strain were evaluated in this study. The non PPNG, PPNG, CMRNG and TRNG/PPNG strains showed good to excellent sensitivity to the quinolones tested. The N. gonorrhoeae strains with a decreased sensitivity against quinolones showed higher MIC (minimum inhibitory concentration) values.
authors.affiliation: Department of Dermatology, University Hospital, Rotterdam-Dijkzigt, The Netherlands.
authors.forename: A H
authors.initials: AH
authors.lastname: van der Willigen
authors.forename: J E
authors.initials: JE
authors.lastname: Degener
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.forename: E
authors.initials: E
authors.lastname: Stolz
authors.forename: J H
authors.initials: JH
authors.lastname: Wagenvoort
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010405:Penicillinase / Q000378:metabolism
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D010405:Penicillinase