[Pharmacokinetics of mepivacaine and lidocaine after epidural administration].
We compare plasma concentrations of mepivacine (MPV) and lidocaine (LDC) after epidural injection in 20 patients. Samples were drawn at 1, 5, 10, 15, 20, 60, and 120 minutes after administration. Absorption from epidural space is equally fast for both anesthetic agents (t max 20 +/- 7 minutes for MPV and 25 +/- 12 minutes for LDC) resulting in high values of Cmax: 7.8 +/- 3.3 microg/ml for MPV and 2.6 +/- 0.7 microg/ml for LDC (p less than 0.001). Mean values of K and Vd were 0.0076 +/- 0.0020 minutes-1 for MPV versus 0.0087 +/- 0.0032 minutes-1 for LDC and 0.9 +/- 0.7 1/kg for MPV versus 1.8 +/- 0.6 1/kg for LDC (p less than 0.001).
Laguarda Rodrigo
M
M
Servicios de Anestesiología y Reanimación y Farmacia Hospitalaria, Hospital Lluís Alcanyís, Xàtiva, Valencia.
Sánchez Alcaraz
A
A
Sangrador García
G
G
Botello Miro
J
J
Herrero Gracia
C
C
D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged
D008012:Lidocaine; D008619:Mepivacaine
Farmacocinética de la mepivacaína y de la lidocaína tras su administración epidural.