Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma.
A 48-year-old Japanese woman died of multiple myeloma (lambda light-chain type) with chronic renal failure. Histological examination revealed deposition of a homogeneous substance and crystals in the kidneys and thyroid gland. The homogeneous substance was stained with Congo red after permanganate treatment but did not stain with antibody to amyloid A protein, and it was recognized as AL-type amyloid. Crystals were not stained with Congo red, but crystals were stained with antibody to the lambda light chain. Since AL-type amyloid is considered to be derived from a myeloma light chain, the present case showed two different types of deposition, both of which were derived from the same myeloma protein.
Hirota
S
S
Department of Pathology, Osaka University Medical School, Japan.
Miyamoto
M
M
Kasugai
T
T
Kitamura
Y
Y
Morimura
Y
Y
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D003461:Crystallography; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007674:Kidney Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013959:Thyroid Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D000682:Amyloid; D007147:Immunoglobulin Light Chains