Comparison of cytogenetic tests for monitoring overexposures from ionizing radiation.
The frequencies of chromosome aberrations induced by ionizing radiations were studied for use in assessment of doses in radiation accidents. The dose-effect relationships of formations of dicentric and acentric aberrations are compared with that of micronuclei detected in cultured human lymphocytes. The data suggest the applicability of micronucleus test as "biological dosimeter" with a similar sensitivity like the widely used dicentric analysis.
Kormos
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Frédéric Joliot-Curie, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Köteles
G J
GJ
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005069:Evaluation Studies as Topic; D005821:Genetic Techniques; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology / Q000528:radiation effects; D011832:Radiation Injuries / Q000175:diagnosis / Q000235:genetics*; D011834:Radiation Monitoring / Q000379:methods*