title: [The course of pregnancy in lupus anticoagulant syndrome].
abstract: More than 95 per cent of the pregnancies with circulating lupus anticoagulant (LA) without therapy lead to abortion or intrauterine death. We report on the course of a pregnancy in a patient, who developed deep venous thrombosis and circulating LA. One of the rare cases of successful pregnancy management without the common prednisolone-aspirin therapy, but with heparin-monotherapy associated with intensive medical and obstetrical surveillance under clinical conditions is reported. In spite of intermittent corticosteroid and immunoglobulin application, a healthy child was born, although normalisation of the aPTT and platelet count was not achieved. It seems, that an alternative concept of therapy may have been established.
authors.affiliation: Landesfrauenklinik Salzburg.
authors.forename: D
authors.initials: D
authors.lastname: Spitzer
authors.forename: A
authors.initials: A
authors.lastname: Staudach
authors.forename: B
authors.initials: B
authors.lastname: Riedl
authors.forename: H
authors.initials: H
authors.lastname: Traun
authors.forename: H
authors.initials: H
authors.lastname: Steiner
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D016682:Lupus Coagulation Inhibitor; D008775:Methylprednisolone / Q000008:administration & dosage; D010951:Plasma Exchange; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology; D011250:Pregnancy Complications, Hematologic / Q000276:immunology* / Q000628:therapy; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D013577:Syndrome; D013924:Thrombophlebitis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D006493:Heparin; D008775:Methylprednisolone
vernacular_title: Schwangerschaftsverlauf bei Lupus anticoagulans-Syndrom.