title: [Study of intestinal absorption of calcium using 47Ca and whole body counter in renal calculosis with hypercalciuria].
abstract: Intestinal calcium absorption was studied using orally administered 47Ca and whole body counting. Using this method, we examined 82 patients suffering from recurrent calcium urolithiasis associated with idiopathic hypercalciuria, to evaluate the incidence of elevated intestinal absorption of this ion. An oral dose of 111 kBq (3 microCi) of 47Ca chloride, together with 250 mg of stable calcium as carrier, was given to each patient. Two hours and one week later, the total body radioactivity of each subject was measured. The retention of 47Ca, as percentage of the administered dose, was then calculated. The measurements were performed with a whole body counter consisting of a two-crystal moving system with shadow shield. Forty age-matched healthy volunteers were also examined. The whole body retention of 47Ca resulted significantly higher (p less than 0.0002) in the group of patients than in the control sample, whose m +/- SD was 22.0 +/- 6.0%. In particular, by defining the normality range as 10-34% (m +/- 2SD of control results), enhanced intestinal absorption of calcium was found in 28% of the examined patients. The use of this simple examination seems to be helpful in the physiopathologic assessment of subjects suffering from calcium urolithiasis and idiopathic hypercalciuria and consequently, in their appropriate management.
authors.affiliation: Servizio di Medicina Nucleare, Ospedale di Circolo di Varese.
authors.forename: S
authors.initials: S
authors.lastname: Garancini
authors.forename: G
authors.initials: G
authors.lastname: Roncari
authors.forename: R
authors.initials: R
authors.lastname: Novario
authors.forename: M
authors.initials: M
authors.lastname: Broggini
authors.forename: V
authors.initials: V
authors.lastname: Bottà
authors.forename: E
authors.initials: E
authors.lastname: Gianneo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D002122:Calcium Chloride / Q000008:administration & dosage; D002132:Calcium Radioisotopes; D002648:Child; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000378:metabolism* / Q000652:urine; D008297:Male; D008875:Middle Aged; D014915:Whole-Body Counting
chemical_list: D002132:Calcium Radioisotopes; D002122:Calcium Chloride; D002118:Calcium
vernacular_title: Studio dell'assorbimento intestinale del calcio mediante 47Ca e misure con whole body counter nella calcolosi renale con ipercalciuria.