Evidence for a role of brain thyrotropin-releasing hormone (TRH) on stress gastric lesion formation in rats.
Specific polyclonal antibodies raised against synthetic thyrotropin-releasing hormone (TRH) infused intracerebroventricularly (ICV) significantly decreased gastric lesions induced by cold restraint stress. The antiulcer effect of immunologic blockade of brain TRH was specific. Normal rabbit serum or antibodies raised against somatostatin, alpha-MSH, Leu-enkephalin, gonadotropin-releasing hormone and atrial natriuretic factor were ineffective. These findings suggest that brain TRH may play an important role in experimental stress ulcer formation.
Hernandez
D E
DE
Division of Gastroenterology, University of Southern California, Los Angeles 90033.
Arredondo
M E
ME
Xue
B G
BG
Jennes
L
L
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D007106:Immune Sera / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications*; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism / Q000502:physiology*
D007106:Immune Sera; D013973:Thyrotropin-Releasing Hormone