Effect of chronic clonidine treatment on urinary growth hormone excretion and linear growth in children with short stature.
Eleven prepubertal children with short stature were treated with clonidine (0.15 mg/m2 daily) for a period of 1 year. The effect of this drug was evaluated on both clinical (growth velocity, height standard deviation scores for chronological age and bone age) and hormonal (urinary growth hormone excretion and insulin-like growth factor I) parameters. Our study shows that long-term clonidine administration in children with short stature did not result in significant differences in growth velocity, height standard deviation scores for chronological age and bone age, insulin-like growth factor I or in urinary growth hormone excretion.
Sanmartí
A
A
Endocrinology Section, Hospital Germans Trias i Pujol, Badalona, Spain.
Lucas
A
A
Granada
M L
ML
Salinas
I
I
Reverter
J L
JL
Cuatrecasas
J M
JM
Foz
M
M
Audi
L
L
D001827:Body Height / Q000187:drug effects*; D002648:Child; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000187:drug effects / Q000652:urine*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000187:drug effects; D008297:Male
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D003000:Clonidine