title: [A trial of adiuretin-SD use in von Willebrand's disease].
abstract: In healthy volunteer donors, intranasal instillation of adiuretin-SD in doses of 0.0002-0.001 mg/kg a day provoked an increase of the activity VIII:WF in the plasma and acceleration of euglobulin lysis. Out of 15 patients suffering from Willebrand's disease, the activity of Willebrand's factor rose in 9 patients. Activated partial thromboplastic time became shorter in all the patients. In addition, acceleration of euglobulin lysis was noted. In view of that fact adiuretin was used later in combination with aminocaproic acid (0.2 g/kg a day). All the patients suffering from menorrhagias demonstrated the lowering of hemorrhagic diathesis. The data obtained allow recommending the use of adiuretin combined with aminocaproic acid in patients suffering from Willebrand's disease.
authors.forename: V I
authors.initials: VI
authors.lastname: Belykh
authors.forename: S I
authors.initials: SI
authors.lastname: Belykh
mesh_terms: D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D013997:Time Factors; D014842:von Willebrand Diseases / Q000097:blood / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000032:analysis / Q000187:drug effects
chemical_list: D000614:Aminocaproates; D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin
vernacular_title: Opyt primeneniia adiuretina-SD pri bolezni Villebrands.