[The effect of inhibitors of ADP ribosylation on the restoration of the mitotic cycle and on DNA repair after the action of ionizing radiation in Chinese hamster cells].
Specific inhibitors of poly(ADP-ribose)polymerase-3-aminobenzamide and 3-metoxybenzamide (6, 12 mM) have been shown to: 1) reduce survival of X-irradiated CHO K1 cells to a slight degree; 2) increase S- and particularly G2-delays in X-irradiated cells, while progressing through the cell cycle as analysed by the DNA flow cytofluorimetry; 3) reduce effectiveness of DNA single-strand breaks repair. The above data suggest a definite role of ADP ribosylation in the cell repair activity.
Kirillova
T V
TV
Rozanov
Iu M
IuM
Seregina
T B
TB
Spivak
I M
IM
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D005260:Female; D008938:Mitosis / Q000187:drug effects* / Q000528:radiation effects; D010053:Ovary / Q000166:cytology; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D013997:Time Factors
D001549:Benzamides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C025160:3-aminobenzamide; D004247:DNA; C025159:3-methoxybenzamide
Vliianie ingibitorov ADF-ribozilirovaniia na vosstanovlenie mitoticheskogo tsikla i na reparatsiiu DNK posle deĭstviia ioniziruiushcheĭ radiatsii v kletkakh kitaĭskogo khomiachka.