title: Haemagglutination-inhibiting (HI) antibodies against strains of influenza A virus in horse and pig sera in Nigeria.
abstract: Sera from horses and pigs obtained from Lagos and Ibadan respectively were examined for haemagglutination-inhibiting (HI) antibodies to two strains each of H3N2 and H1N1 subtypes of influenza A virus. More horse sera had HI antibodies to the H3N2 than the H1N1 strains while pig sera reacted almost equally with strains of both subtypes. All the horse sera had HI antibodies to the two strains of H3N2 subtype (A/Mississippi/1/85 and A/Leningrad/360/86), while 87% and 14% of the horses examined were positive to A/Taiwan/1/86 and A/Chile/1/83. On the other hand HI antibody prevalence to the two subtypes in pigs are as follows, for H3N2 A/Mississippi/1/85 (86%), A/Victoria/3/75 (94%); for H1N1 A/Chile/1/83 (87%) and A/Taiwan 1/86 (79%). Analysis of the data by the Chi-square test showed significant difference between the prevalence of HI antibodies to the influenza A virus strains in horse sera examined while there was no significant difference between HI antibody prevalence to the four strains in pigs. The study shows that horses and pigs circulate influenza A virus in Nigeria and may serve as origin of human epidemics.
authors.affiliation: Department of Virology, College of Medicine, University of Ibadan, Nigeria.
authors.forename: O D
authors.initials: OD
authors.lastname: Olaleye
authors.forename: S A
authors.initials: SA
authors.lastname: Omilabu
authors.forename: S S
authors.initials: SS
authors.lastname: Baba
authors.forename: A H
authors.initials: AH
authors.lastname: Fagbami
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification*; D006385:Hemagglutination Inhibition Tests; D006736:Horses / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D009549:Nigeria; D013552:Swine / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral