title: Synthesis of 3-aryl-2-substituted-4(3H)-quinazolines as potential antimicrobial agents.
abstract: Three new series of 4(3H)-quinazolinone derivatives were synthesized, namely: [3-Aryl-4(3H)-quinazolinon-2-yl]-methylenehydrazino-(N- substituted)-thiocarbamides, 3-Aryl-2-(3-substituted-4-phenyl-2,3-dihydrothiazol-2-ylidenehy drazonomethyl)-4 (3H)-quinazolinones and 3-Aryl-2-(3-substituted-4-oxothiazolidin-2-ylidenehydrazonometh yl)-4(3H)-quinazolinones. The antimicrobial activities of the synthesized compounds were also studied.
authors.affiliation: Departement of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Farghaly
authors.forename: A
authors.initials: A
authors.lastname: Mohsen
authors.forename: M E
authors.initials: ME
authors.lastname: Omar
authors.forename: M A
authors.initials: MA
authors.lastname: Khalil
authors.forename: M A
authors.initials: MA
authors.lastname: Gaber
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001409:Bacillus cereus / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011799:Quinazolines