Hemorheologic effects of Meclomen including effect in malignant melanoma.
Sodium Meclofenamate, (Meclomen) (M) is a non-steroidal anti-inflammatory drug, which inhibits both cyclooxygenases and lipooxygenases of the arachidonic acid cascade (AA). (M) inhibited adenosine diphosphosphate (ADP) induced platelet aggregation, arachidonic acid (AA) induced platelet aggregation and collagen induced platelet aggregation. (M) inhibited platelet factor 3 availability when measured by Stypven clotting time. Red cells from patients with advanced malignancies and normal red cells stored in blood banks exhibited loss of deformability. (M) enhanced red cell deformability in these blood samples.
Mahafzah
M
M
Department of Medicine, Sister's of Charity Hospital, Buffalo, NY.
Stadler
S
S
Qazi
K
K
Ambrus
J L
JL
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001809:Blood Viscosity / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004907:Erythrocyte Deformability / Q000187:drug effects*; D016859:Lipoxygenase Inhibitors; D008469:Meclofenamic Acid / Q000494:pharmacology*; D008545:Melanoma / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010977:Platelet Factor 3 / Q000032:analysis; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D062367:ortho-Aminobenzoates; D016718:Arachidonic Acid; D010977:Platelet Factor 3; D008469:Meclofenamic Acid; D003094:Collagen