[Effect of thrombolytic, anticoagulant and anti-thrombocytic therapy on the development of left-ventricular thrombosis and the incidence of thromboembolic complications in patients with myocardial infarction].
To reveal the effects produced by thrombolytic and anticoagulative therapies on the formation of left ventricular mural thrombosis (LVT) and the frequency of thromboembolic events, a prospective randomized study was performed in 285 patients with primary transmural myocardial infarction. LVT was diagnosed from the serial two-dimensional echocardiographic findings. No significant effect of the therapy with thrombolytic and anticoagulative agents was found on the incidence and periods of intracavitary LVT development. There was a significant reduction in the incidence of LVT during early (less than 3 hours) reperfusion of the occluded coronary artery. Anticoagulative and antiplatelet therapies performed within the first month of myocardial infarction decrease the risk for systemic thromboembolism in patients with diagnosed LVT.
Chikvashvili
D I
DI
Rado
Iu
Iu
Staroverov
I I
II
Ruda
M Ia
MIa
D001777:Blood Coagulation / Q000187:drug effects; D003327:Coronary Disease / Q000517:prevention & control*; D003328:Coronary Thrombosis / Q000209:etiology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D010974:Platelet Aggregation / Q000187:drug effects; D012307:Risk Factors; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy
D006493:Heparin; D013300:Streptokinase; D005996:Nitroglycerin
Vliianie tromboliticheskoĭ iantitrombotsitarnoĭ terapii na razvitie tromboza levogo zheludochka i chastoty tromboémbolicheskikh oslozh- neniĭ u bol'nykh infarktom miokarda.