Pentavalent antimonial nephrotoxicity in the rat.
Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sbv (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis.
Veiga
J P
JP
Departamento de Clínica Médica, Faculdade de Ciéncias da Saúde, Universidade de Brasília, Brasil.
Khanam
R
R
Rosa
T T
TT
Junqueira Júnior
L F
LF
Brant
P C
PC
Raick
A N
AN
Friedman
H
H
Marsden
P D
PD
D000818:Animals; D000981:Antiprotozoal Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008297:Male; D008536:Meglumine / Q000633:toxicity*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000633:toxicity*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D014867:Water; D008536:Meglumine; D000077485:Meglumine Antimoniate; D012964:Sodium