title: Pleural eosinophil infiltration induced by PAF-acether is not a desensitizable phenomenon.
abstract: This study investigated the effect of successive daily intrathoracic (it) injections of PAF-acether upon its demonstrated ability to generate eosinochemotaxin(s). Repeated administration of PAF-acether led to a selective state of desensitization, characterized by a gradual reduction of its ability to induce exudation. Concomitantly, however, there was a progressive pleural accumulation of eosinophils leading to a 7-fold increase in the eosinophil counts after the 4th restimulation. The generation of eosinochemotaxin(s) elicited by PAF-acether was not modified by desensitization, as detected by transferring the cell-free pleural fluid from donor to recipient animals. We conclude that, in contrast to exudation, eosinophil tissue infiltration induced by PAF-acether is not a desensitizable phenomenon.
authors.affiliation: Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil.
authors.forename: P M
authors.initials: PM
authors.lastname: Silva
authors.forename: M A
authors.initials: MA
authors.lastname: Martins
authors.forename: H C
authors.initials: HC
authors.lastname: Castro-Faria-Neto
authors.forename: P T
authors.initials: PT
authors.lastname: Bozza
authors.forename: H N
authors.initials: HN
authors.lastname: Cruz
authors.forename: M T
authors.initials: MT
authors.lastname: Dias
authors.forename: R S
authors.initials: RS
authors.lastname: Cordeiro
authors.forename: B B
authors.initials: BB
authors.lastname: Vargaftig
mesh_terms: D000818:Animals; D002449:Cell Aggregation / Q000187:drug effects; D004802:Eosinophilia / Q000139:chemically induced*; D004804:Eosinophils / Q000502:physiology*; D005260:Female; D008297:Male; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D010996:Pleural Effusion / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010972:Platelet Activating Factor