title: smellblind: a gene required for Drosophila olfaction.
abstract: In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and deficiency mapping are used to localize this gene, sbl, to cytogenetic position 14F6-15A2-3 on the X chromosome. Mutations of the locus are shown to produce severe defects not only in larval olfactory response to several volatile chemicals, but also in larval contact chemosensory response. Both sbl and olfDx9 give a robust response, however, in a new test of larval phototactic response, which we describe here. Both alleles are shown to be heat-sensitive lethals. Four additional recessive lethal alleles, two EMS-induced, one dysgenic, and one spontaneous, are also described.
authors.affiliation: Department of Biology, Yale University, New Haven, Connecticut 06511.
authors.forename: M
authors.initials: M
authors.lastname: Lilly
authors.forename: J
authors.initials: J
authors.lastname: Carlson
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D006358:Hot Temperature; D009154:Mutation; D010641:Phenotype; D011995:Recombination, Genetic; D012903:Smell / Q000502:physiology; D014960:X Chromosome