Development of long-acting nitrate delivery systems.
In this paper pharmaceutical and biopharmaceutical aspects on the development of long-acting nitrate delivery systems are reviewed. Basic considerations and requirements are also discussed. Recent product development activities are presented, with an emphasis on nitroglycerin in transdermal form and oral isosorbide-5-mononitrate controlled-release formulations.
Jonsson
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Pharmaceutical Research and Development, AB Hässle, Mölndal, Sweden.
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000787:Angina Pectoris / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D009566:Nitrates / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage
D003692:Delayed-Action Preparations; D009566:Nitrates; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate