title: Inverse relation between severity of psoriasis and serum 1,25-dihydroxy-vitamin D level.
abstract: The serum levels of calcium, inorganic phosphate, parathyroid hormone, calcitonin, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured in 34 patients with psoriasis vulgaris and compared with the severity of skin lesions. Severity of psoriasis was evaluated by three indices, the area-severity index (ASI), the area index (AI) and the severity index (SI), determined as the product of the area and severity, the area, and the severity of the individual skin lesions, respectively. The mean basal levels of these serum parameters were within the normal range. ASI and SI showed significant inverse correlations (r = -0.387, P less than 0.05 and r = -0.638, P less than 0.01, respectively) with the serum level of 1,25-dihydroxyvitamin D, but not with any other serum parameters, but AI was not correlated with any of these serum parameters. These data suggest that psoriatic patients are not deficient in 1,25-dihydroxyvitamin D, but that development of this skin disease may be related to a slightly decreased level of active metabolites of vitamin D or abnormalities in the responsiveness of the skin cells to them.
authors.affiliation: Department of Geriatric Medicine, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Fukuo
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
authors.forename: E
authors.initials: E
authors.lastname: Koh
authors.forename: S
authors.initials: S
authors.lastname: Imanaka
authors.forename: S
authors.initials: S
authors.lastname: Kitano
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002112:Calcifediol / Q000097:blood; D002116:Calcitonin / Q000097:blood; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011565:Psoriasis / Q000097:blood / Q000473:pathology*; D011863:Radioimmunoassay; D012720:Severity of Illness Index
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D002116:Calcitonin; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium