Specific IgG and IgE responses to Dermatophagoides pteronyssinus in Sprague-Dawley rats.
Specific IgG and IgE antibodies against the mite Dermatophagoides pteronyssinus (Dp) have been determined in the serum of Sprague Dawley (SD) rats by enzyme linked immunosorbent assay (ELISA) and passive cutaneous anaphylaxis (PCA), respectively. Immunization of rats with Dp produces a rapid increase of serum specific IgE antibody levels which decrease when specific IgG antibodies start rising. The results indicate that the SD rat is a good model to induce a humoral immune response to allergen Dp.
Gilabert
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A
Departament de Ciències Fisiològiques Humanes i de la Nutrició, Facultat de Farmacia, Universitat de Barcelona, Spain.
Salgado
J
J
Franch
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A
Queralt
J
J
Torralba
A
A
D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008925:Mites / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007074:Immunoglobulin G; D007073:Immunoglobulin E