[The effect of 1,25-dihydroxycholecalciferol on immunity and the clinical state and on parameters of phospho-calcium metabolism in dialyzed patients].
Sixteen months of administration of 1,25-dihydroxycalciferol (Rocaltrol) to twelve patients with chronic renal failure led to a substantial reduction of infectious complications during the investigation period and to improvement of the clinical condition of the patients evaluated with regard to bone and muscle pain. In laboratory indicators of immunity the authors observed an increase of the originally reduced values of phagocytosis of C, albicans and candidacidal after two weeks' administration of the drugs. Changes in the ratio of sub-populations of lymphocytes were apparent also after 16 months therapy: the authors observed a continuous decline of the lymphocyte B and lymphocyte T4 ratio and rise of the cytotoxic suppressor fraction CD8+ of lymphocytes. The different trend of changes of some immunological, biochemical and clinical indicators was apparent when the patients were subdivided according to the aetiology of renal failure.
Bartůnková
J
J
Oddĕlení klinické imunologie 1. lékarské fakulty Univerzity Karlovy, Praha.
Sulková
S
S
Fucíková
T
T
Marecková
H
H
Válek
A
A
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D016131:Lymphocyte Subsets / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects; D010758:Phosphorus / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects
D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium
Vilv 1,25-dihydroxycholekalciferolu na imunitní a klinický stav a na parametry fosfokalciového metabolismu dialyzovaných pacientů.