title: [Demonstration of LH inhibitor(s) in sheep and human sera].
abstract: In mature rat Leydig cells, the testosterone output (24 ng/10(6) Leydig cells/4hrs.) is increased 10 fold by LH; the addition of serum from either control or castrated or hypophysectomized rams inhibits (60%) the LH-stimulated testosterone production. Similarly, the incubation of immature rat Leydig cells with sera from hypophysectomized patients leads to a diminution (70 and 30% respectively) of both basal (0.98 ng) and LH stimulated (3.44 ng) testosterone biosynthesis. These data suggest the existence of an LH inhibitor (or inhibitors) in blood from ram and human; in addition, this substance is not only of testicular origin and is not an LH-related molecule.
authors.affiliation: I.N.R.A., Nouzilly.
authors.forename: N
authors.initials: N
authors.lastname: Boujrad
authors.forename: I
authors.initials: I
authors.lastname: Denis
authors.forename: V
authors.initials: V
authors.lastname: Papadopoulos
authors.forename: C
authors.initials: C
authors.lastname: Pisselet
authors.forename: P
authors.initials: P
authors.lastname: Bouchard
authors.forename: M A
authors.initials: MA
authors.lastname: Drosdowsky
authors.forename: M T
authors.initials: MT
authors.lastname: Hochereau de Reviers
authors.forename: S
authors.initials: S
authors.lastname: Carreau
mesh_terms: D000818:Animals; D006801:Humans; D007016:Hypophysectomy; D007985:Leydig Cells / Q000378:metabolism; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors* / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051381:Rats; D012756:Sheep / Q000097:blood*; D013739:Testosterone / Q000096:biosynthesis
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone
vernacular_title: Mise en évidence d'un (ou des) inhibiteur(s) de LH dans les sérums ovin et humain.