Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.
Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.
Reuter
G
G
Department of Genetics, Martin Luther University, Halle, DDR.
Giarre
M
M
Farah
J
J
Gausz
J
J
Spierer
A
A
Spierer
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics*; D006570:Heterochromatin; D008667:Metalloproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010766:Phosphorylation; D010858:Pigmentation / Q000235:genetics; D015183:Restriction Mapping; D013489:Suppression, Genetic
D004268:DNA-Binding Proteins; D006570:Heterochromatin; D008667:Metalloproteins; D004247:DNA