title: Influenza: pathogenesis and host defense.
abstract: Why does influenza virus variously eventuate in mild upper respiratory tract infection, bacterial pneumonia, or rapidly fatal viral pneumonia? The depth of infection is important. So is competence of immunologic effectors--local antibody (secretory IgA) for preventing URI, systemic antibody for preventing pneumonia, and cellular immunity for recovery from either.
authors.affiliation: University of Florida College of Medicine, Gainesville.
authors.forename: P A
authors.initials: PA
authors.lastname: Small
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007071:Immunoglobulin A, Secretory / Q000502:physiology; D007231:Infant, Newborn; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control / Q000635:transmission; D009975:Orthomyxoviridae / Q000472:pathogenicity* / Q000502:physiology; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000276:immunology; D011024:Pneumonia, Viral / Q000276:immunology / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007252:Influenza Vaccines