Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs.
The influence of 22 flavonoids was studied on the arachidonic acid metabolism in sonicated sheep platelets. Flavones and flavonols possessing catechol groups inhibited 12-lipoxygenase. Sideritoflavone and quercetagetin-7-O-beta-D-glucoside were more selective than quercetin. Cirsiliol, hypolaetin, hypolaetin-8-O-beta-D-glucoside, gossypetin, gossypin, hibifolin and leucocyanidol were also 12-lipoxygenase inhibitors with some differences in potency and selectivity. Xanthomicrol was a weak cyclooxygenase inhibitor. These results suggest that lipoxygenase inhibition can play a role in the anti-inflammatory activity of hypolaetin-8-O-beta-D-glucoside, sideritoflavone, gossypin and hibifolin. On the other hand, the presence of sideritoflavone, hypolaetin-8-O-beta-D-glucoside, cirsiliol and xanthomicrol in several species of Sideritis may provide a basis for the use of such plants as anti-inflammatory agents.
Ferrándiz
M L
ML
Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Valencia, Spain.
Nair
A G
AG
Alcaraz
M J
MJ
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005419:Flavonoids / Q000494:pharmacology*; D007194:India; D010946:Plants, Medicinal / Q000032:analysis*; D012756:Sheep; D013030:Spain
D001095:Arachidonic Acids; D005419:Flavonoids; D016718:Arachidonic Acid