Formation of oxygenase and hydroperoxidase products by the pure reticulocyte lipoxygenase.
The pure reticulocyte lipoxygenase oxygenates free arachidonic acid to 15S- and 12S-HPETE in a ratio of about 10:1 15S-H(P)ETE or its methyl ester can be further converted by the lipoxygenase via three different types of reactions: (i) oxygenase reaction, (ii) hydroperoxidase reaction and (iii) leukotriene synthase reaction. Here we summarize the products formed from arachidonic acid by the reticulocyte lipoxygenase via these three types of reactions.
Kühn
H
H
Institute of Biochemistry, School of Medicine (Charité), Humboldt University, Berlin, GDR.
Wiesner
R
R
Schewe
T
T
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D015289:Leukotrienes / Q000378:metabolism; D008025:Ligases / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D012156:Reticulocytes / Q000201:enzymology*
D005231:Fatty Acids, Unsaturated; D015289:Leukotrienes; D008054:Lipid Peroxides; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D010544:Peroxidases; D008084:Lipoxygenase; D008025:Ligases