Nontoxic concentration of ceftazidime and flomoxef sodium for intravitreal use--evaluated by in-vitro ERG.
The effects of ceftazidime (CAZ) and flomoxef sodium (FMOX) on the in-vitro electroretinogram (ERG) of albino rabbits were studied. The a-wave, the b-wave and the oscillatory potential (OP) were unchanged by 0.3mM (0.19mg/ml) CAZ-containing solution. The OP was suppressed by 0.5mM (0.32mg/ml) CAZ. The a-wave, the b-wave and the OP were unchanged by 0.5mM (0.26mg/ml) FMOX. The OP was suppressed and its peak latency was delayed by 2mM (0.52mg/ml) FMOX. The concentration of 0.3mM (0.19mg/ml) CAZ was higher than its minimum inhibitory concentration (MIC) against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Serratia marcescens and Propionibacterium acnes. The concentration of 0.5mM (0.26mg/ml) FMOX was higher than its MIC against Staphylococcus aureus, Staphylococcus epidermidis, Serratia marcescens and Propionibacterium acnes.
Tanabe
J
J
Department of Ophthalmology, Kanazawa University School of Medicine, Japan.
Kitano
K
K
Suzuki
T
T
Okayama
Y
Y
Mochizuki
K
K
Kawasaki
K
K
D000818:Animals; D002442:Ceftazidime / Q000633:toxicity*; D002511:Cephalosporins / Q000633:toxicity*; D004596:Electroretinography / Q000187:drug effects*; D009877:Endophthalmitis / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D066298:In Vitro Techniques; D009991:Oscillometry; D010477:Perfusion; D011817:Rabbits; D012160:Retina / Q000502:physiology*; D014822:Vitreous Body / Q000502:physiology*
D002511:Cephalosporins; D002442:Ceftazidime; C045693:flomoxef