Thrombocytopathy due to a defect of the platelet membrane complex.
A new type of primary thrombocytopathy is described. Three main alterations were found: (1) a defect of the aggregation reaction with ADP, epinephrine and collagen and a normal response to ristocetin and arachidonic acid; (2) a moderate deficiency of platelet procoagulant activity, and (3) a combined hypertrophy of the two membrane systems of the platelet--the open canalicular and the dense tubular. The latter defect is shown as an abnormal membrane complex situated on one of the platelet poles. This thrombocytopathy is discussed as a new variety of primary platelet disorder.
Canizares
C
C
Department of Hematology, Hospital Andrade Marin, IESS, Quito, Ecuador.
Vivar
N
N
Grijalva
J
J
D000328:Adult; D001791:Blood Platelet Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D001792:Blood Platelets / Q000648:ultrastructure*; D002462:Cell Membrane / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D013499:Surface Properties