In vivo effect of selenium on the mutagenic activity of aflatoxin B1.
Experiments were carried out to verify the effect of selenium on the mutagenic activity of AFB1. After 14 days of selenium administration to experimental animals (Chinese hamsters, Cricetulus griseus) in the form of 2 ppm Na2SeO3 solution available ad libitum the incidence of chromosomal aberrations in bone marrow cells due to a single p.o. administration of 5 mg AFB1 per 1 kg body weight was significantly reduced. The incidence of chromosomal aberrations was monitored till day 32 after AFB1 administration. A significant decrease in the frequency of aberrant cells, breaks and gaps was observed at almost any time during the investigation. 2 ppm Na2SeO3 solution itself did not enhance the frequency of chromosomal aberrations. The mechanism of the protective effect of selenium vis-a-vis the mutagenic and carcinogenic action of AFB1 remains obscure.
Petr
T
T
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Bárta
I
I
Turek
B
B
D016604:Aflatoxin B1; D000348:Aflatoxins; D000818:Animals; D001854:Bone Marrow Cells; D002273:Carcinogens; D002869:Chromosome Aberrations / Q000502:physiology*; D006224:Cricetinae; D003412:Cricetulus; D008297:Male; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D013997:Time Factors
D000348:Aflatoxins; D002273:Carcinogens; D016604:Aflatoxin B1; D012643:Selenium