[The photosensitization of uveal melanoma cells by ionizing radiation].
A study of the character of changes in melanoma cells "in vitro" subjected to successive beta-radiation and light energy of low intensity has revealed a more expressed loss of cells as compared with a "pure" ionizing action. Essential differences in the cells density in the monolayer appear already by the 3d-8th day and reach the maximum 2-3 weeks later. The dynamics of changes in the cells density isn't connected with the cellular type of the tumor and initial density isn't connected with the cellular type of the tumor and initial density of their distribution in the monolayer. The duration of the culture existence becomes shorter. If monolayers not subjected to the action perished after 54.0 +/- 6.2 days, after beta-radiation 35.2 +/- 2.4 days later, then after combined action they perished 17.2 +/- 2.6 days later. Thus, the effect was revealed that is actually opposite to a recently discovered phenomenon of photoreactivation of ionizing injury. Despite difficulty of interpreting possible mechanisms of the discovered phenomenon, it is already possible to suggest about its possibility to be used in treatment of pigmentary new formations.
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D001610:Beta Particles / Q000627:therapeutic use; D003116:Color; D006801:Humans; D008027:Light; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000473:pathology / Q000528:radiation effects; D014604:Uveal Neoplasms / Q000473:pathology / Q000532:radiotherapy*
O fotosensibilizatsii kletok uveal'nykh melanom ioniziruiushchim izlucheniem.