[Interaction of quartz with human erythrocyte membrane--major protein changes and the effect of aluminium citrate].
The changes of the major proteins of human erythrocyte membrane by quartz were analysed by SDS-polyacrylamide gel electrophoresis. The relative mobility of proteins remained unchanged, whilst the relative abundance of Band 3 and PAS-1 proteins decreased (stained with Coomassie blue and PAS). The adsorption of Band 3 on to quartz were dose- and time-dependent. Aluminium citrate can inhibit the quartz adsorptive activity. The results support that the membrane damage of quartz is related to interacting with Band 3 proteins.
Zhang
B
B
School of Public Health, Beijing Medical University.
D001457:Anion Exchange Protein 1, Erythrocyte / Q000187:drug effects*; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects*; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D011791:Quartz
D001457:Anion Exchange Protein 1, Erythrocyte; D002951:Citrates; D004391:Dust; D011791:Quartz; D019343:Citric Acid