Interstitial pneumonitis associated with ifosfamide therapy.
Ifosfamide and cyclophosphamide have many toxicities in common. Interstitial pneumonitis has not been reported previously as a side effect of ifosfamide therapy. The authors report the case of a 58-year-old woman who was treated with ifosfamide for soft tissue sarcoma. After the fifth cycle of chemotherapy she developed clinical evidence of interstitial pneumonitis, a diagnosis that was later confirmed at autopsy. The authors suggest that ifosfamide therapy was directly related to this patient's fatal case of interstitial pneumonitis.
Baker
W J
WJ
Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5001.
Fistel
S J
SJ
Jones
R V
RV
Weiss
R B
RB
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015080:Mesna / Q000008:administration & dosage; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology
D003606:Dacarbazine; D004317:Doxorubicin; D015080:Mesna; D007069:Ifosfamide