[HLA antigens in juvenile rheumatoid arthritis].
Antigens of I class HLA system (locus A and B) were investigated in 67 patients of Latvian nationality suffering from juvenile rheumatoid arthritis (JRA). Associations of HLA antigens with juvenile rheumatoid arthritis partially coincided with the ones revealed earlier. Typing established an increased incidence of antigen B27 (p less than 0.01) and gaplotype A2, B40 (p less than 0.01). Antigen B15 possessed a protective action with respect to JRA. Interlocus combinations demonstrated a closer association with the disease than a single antigen. The authors also revealed markers of various clinico-anatomical variants of JRA.
Rumba
I V
IV
Sochnev
A M
AM
Kukaĭne
E M
EM
Burshteĭn
A M
AM
Benevolenskaia
L I
LI
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000209:etiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005819:Genetic Markers / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D007223:Infant; D007844:Latvia; D010641:Phenotype
D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen
Antigeny sistemy HLA pri iuvenil'nom revmatoidnom artrite.