title: Degenerative changes, DNA synthesis and mitotic activity in rat liver following single and repeated exposure to fenarimol.
abstract: Degenerative changes were observed in liver of rats treated with single and repeated doses of fenarimol (250 mg/kg body weight x day). Regenerative changes i.e. increase in: DNA synthesis, hepatic DNA, mitotic activity and number of binuclear hepatocytes, were also noted.
authors.affiliation: Department of Sanitary Toxicology National Institute of Hygiene, Warsaw, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Palut
authors.forename: J
authors.initials: J
authors.lastname: Kopeć-Szlezak
mesh_terms: D000818:Animals; D002452:Cell Count / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D011743:Pyrimidines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005659:Fungicides, Industrial; D011743:Pyrimidines; D004247:DNA; C033789:fenarimol