A new Igk-V gene family in the mouse.
We have identified and characterized a novel mouse Igk-V gene family, which we have designated Igk-V34. Southern hybridization and nucleotide sequence analysis indicate that this family is comprised of either one or two members in mice of different Igk haplotypes. The gene family members share between 95% and 98% sequence similarity, indicating that they diverged only recently during the evolution of the Igk locus. Sequence relationships between members of this family are discussed.
Valiante
N M
NM
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Caton
A J
AJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D005784:Gene Amplification; D005803:Genes, Immunoglobulin / Q000235:genetics*; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains