title: The role of surgery in the treatment of localized Ewing's sarcoma.
abstract: This study includes 193 patients affected with localized Ewing's sarcoma and treated at the Rizzoli Orthopaedic Institute between April 1972 and May 1988. It is the purpose of this study to evaluate the efficacy of surgical treatment with regard to the prognosis of patients affected with E.S. and to define its indications as well as its limits as compared with radiotherapy. Ninety patients were treated surgically: 13 underwent amputation (localization of the disease in the leg and foot), 4 underwent debulking, 48 had resection of the tumor without any reconstruction (expendable bones), while for 25 other patients resection of the tumor required alloplastic or allograft replacement. In cases of E.S. localized in the pelvis and spine, surgery did not obtain improvement in prognosis. In the other sites, the percentage of disease-free patients increased from 57% to 72% in cases where surgery +/- radiotherapy was used instead of radiotherapy alone, while the percentage of local recurrences decreased from 18% to 5.5%, respectively. As for functional results, the highest incidence of excellent to good scores was obtained with surgery associated with radiotherapy (69%). The incidence of complications was only slightly different for the two groups.
authors.affiliation: Centro Tumori Ossei, Istituto Ortopedico Rizzoli, Bologna.
authors.forename: A
authors.initials: A
authors.lastname: Sudanese
authors.forename: A
authors.initials: A
authors.lastname: Toni
authors.forename: D
authors.initials: D
authors.lastname: Ciaroni
authors.forename: M
authors.initials: M
authors.lastname: Avella
authors.forename: D
authors.initials: D
authors.lastname: Dallari
authors.forename: P
authors.initials: P
authors.lastname: Picci
authors.forename: G
authors.initials: G
authors.lastname: Bacci
authors.forename: E
authors.initials: E
authors.lastname: Barbieri
authors.forename: A
authors.initials: A
authors.lastname: Mancini
authors.forename: M
authors.initials: M
authors.lastname: Campanacci
mesh_terms: D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D011182:Postoperative Care; D011300:Preoperative Care; D012074:Remission Induction; D012512:Sarcoma, Ewing / Q000150:complications / Q000453:epidemiology / Q000601:surgery*