Studies on monensin toxicity in goats.
This study was carried out to examine the effect of orally administered monensin on the liver of goats. Goats given monensin at the rate of 55 mg/kg of feed (55 ppm) for three weeks showed clinical signs of anorexia and diarrhea, along with increased pentobarbital sleeping time and serum SDH level indicating the possible presence of hepatotoxicity. On the other hand, animals fed monensin at 11 ppm for three weeks or 8 mg/kg of body weight/day for five days showed no signs of hepatotoxicity.
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Toxicology Laboratory, School of Veterinary Medicine, Tuskegee University, Alabama 36088.
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D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D015511:Goat Diseases / Q000139:chemically induced*; D006041:Goats; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000662:veterinary*; D008297:Male; D008985:Monensin / Q000633:toxicity*
D008985:Monensin