Severe ischemia of the hand following intra-arterial promazine injection: effects of vasodilation, anticoagulation, and local thrombolysis with tissue-type plasminogen activator.
Promazine hydrochloride was injected accidentally in the antecubital artery of a 42-year-old woman, resulting in severe ischemia of the second and third fingers of her right hand which lasted for four days before she was hospitalized. Vasodilation by combining axillary plexus block and intravenous sodium nitroprusside did not improve ischemia and local thrombolysis was performed using recombinant tissue-type plasminogen activator (50 mg over 8 hours), resulting in normalization of digital pressure in one of the two affected fingers. The outcome was favourable and amputation could be avoided.
Bounameaux
H
H
Department of Medicine, University Hospital of Geneva, Switzerland.
Schneider
P A
PA
Huber-Sauteur
E
E
Jolliet
P
P
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000139:chemically induced* / Q000628:therapy; D009599:Nitroprusside / Q000008:administration & dosage; D011395:Promazine / Q000008:administration & dosage / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000008:administration & dosage; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage
D011994:Recombinant Proteins; D009599:Nitroprusside; D006493:Heparin; D010959:Tissue Plasminogen Activator; D011395:Promazine