Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.
Isoelectric focusing on agarose gel was used to separate the isoenzymes of serum galactosyltransferase (uridine diphosphogalactose: N-acetylglucosaminyl galactosyltransferase, EC 2.4.1.22) from 8 healthy women, and 11 ovarian cancer patients of whom 4 were in clinical remission. In all cases, we found 7 major peaks with isoelectric points ranging from 4.0-5.4. The most acidic peaks were preferentially elevated in the tumor-bearing patients, particularly the peak with pI 4.44.
Malas
J P
JP
Laboratoire de Biochimie, UFR des Sciences Pharmaceutiques, Caen, France.
Bar
E
E
Gauduchon
P
P
Sichel
F
F
Le Talaer
J Y
JY
D000368:Aged; D002277:Carcinoma / Q000201:enzymology*; D005260:Female; D005700:Galactosyltransferases / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing / Q000379:methods; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology*
D007527:Isoenzymes; D005700:Galactosyltransferases