[2 year interferon therapy of metastatic carcinoid tumor].
A 39 year old male patient was treated with daily 5 X 10(6) IU interferon alpha 2b s.c. for 22 months because of advanced carcinoid tumor. Objective response was achieved with greater than 50% reduction of 5-HIAA-excretion. Multiple metastases (liver, lung, bones, thyroid gland) were not progressing in size. An unintentional omission of treatment resulted in a rapid biochemical and morphological tumor progression. Reversibility was achieved with reinstitution of effective interferon therapy. Thus, interferon therapy of advanced carcinoid tumor is able to induce a long-term objective response. It seems to be superior to conventional chemotherapy.
von Scheidt
W
W
Medizinische Klinik I, Klinikum Grosshadern, Universität München.
Böhm
M
M
Huber
I
I
Habersetzer
R
R
Jacob
K
K
Markl
A
A
Autenrieth
G
G
D000328:Adult; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008134:Long-Term Care; D008175:Lung Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D009362:Neoplasm Metastasis; D011994:Recombinant Proteins
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Zweijährige Interferon-Therapie eines metastasierten Carcinoids.