Transforming growth factors type beta 1 and beta 2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-gamma and tumor necrosis factor-alpha.
The transforming growth factors (TGF) type beta 1 and beta 2 are regulatory cytokines strongly affecting rat astrocyte immune functions. Both cytokines suppressed presentation of autoantigen by astrocytes: highly encephalitogenic T cells cocultured with TGF-beta-treated astrocytes in the presence of myelin basic protein did not become activated to transfer experimental allergic encephalomyelitis, a central nervous system (CNS) autoimmune disease. Furthermore, TGF-beta 1 and -beta 2 antagonized hyperinduction of astrocyte major histocompatibility complex (MHC) class II antigen expression by interferon-gamma and tumor necrosis factor-alpha. Thus, TGF-beta might be a potential regulator of CNS inflammation.
Schluesener
H J
HJ
Clinical Research Unit for Multiple Sclerosis, Max-Planck-Society, Würzburg, F.R.G.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D001253:Astrocytes / Q000276:immunology* / Q000378:metabolism; D001324:Autoantigens / Q000276:immunology*; D002460:Cell Line; D015232:Dinoprostone / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007213:Indomethacin / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D051381:Rats; D015291:Transforming Growth Factors / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D014409:Tumor Necrosis Factor-alpha; D015291:Transforming Growth Factors; D007371:Interferon-gamma; D015232:Dinoprostone; D007213:Indomethacin