title: [Use of derivative UV spectroscopy to monitor the percutaneous absorption of befunolol-HCL].
abstract: Second-order derivative UV spectroscopy was used to measure the transfer of befunolol-HCl across full-thickness rabbit skin in vitro. The effect of penetration enhancers, azone-PG and PEG-400, on permeation course of befunolol-HCl was studied. A type of horizontal diffusion cell was employed. Permeability coefficients were measured in normal saline and in solutions containing the enhancing agents. The results indicated that befunolol-HCl may be an interesting candidate for transdermal administration and azone-PG highly and significantly increases the skin permeation of the drug in the solvent system tested.
authors.affiliation: Department of Pharmaceutical Science, Shengyang College of Pharmacy.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: J M
authors.initials: JM
authors.lastname: Zheng
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D011412:Propanolamines / Q000493:pharmacokinetics*; D011817:Rabbits; D012869:Skin Absorption / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001381:Azepines; D011412:Propanolamines; C035229:laurocapram; C006034:befunolol