title: [Antimycobacterial acting 2-hydroxyquinolizin-4-ones].
abstract: Reaction of ethyl 2-pyridyl acetates and activated malonates (magic malonates) leads to 1-ethoxycarbonyl-2-hydroxy-quinolizin-4-ones, which yield the corresponding C-1 unsubstituted derivatives by hydrolysis and decarboxylation. These compounds are catalytically hydrogenated to afford the corresponding tetrahydro derivatives. Significant inhibitory effects on mycobacterium tuberculosis H 37 Ra are shown, a structure-activity relationship is discussed.
authors.affiliation: Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität Frankfurt.
authors.forename: G
authors.initials: G
authors.lastname: Dannhardt
authors.forename: T
authors.initials: T
authors.lastname: Kappe
authors.forename: W
authors.initials: W
authors.lastname: Meindl
authors.forename: B
authors.initials: B
authors.lastname: Schober
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D011807:Quinolizines
vernacular_title: Antimykobakteriell wirksame 2-Hydroxychinolizin-4-one.