title: [Adsorptive stripping voltammetry of chlorprothixene at glassy carbon electrode].
abstract: A new electrochemical stripping method for measuring the antipsychotic drug chlorprothixene was reported. The drug, which was adsorbed on the surface of glassy carbon electrode, showed a sharp oxidative stripping peak at about +0.7 V (vs. Ag-AgCl) in voltammetry. The response was linear over the 0.01-1 microgram/ml concentration range. The detection limit was 2 ng/ml, about 400 times higher than UV method. The electrode surface was polished with alumina between the measurements to activate the electrode and provide good reproducibility. The open circuit accumulation/medium exchange/stripping voltammetry scheme has been proposed to avoid interference. The method has been used for direct determination of chlorprothixene in tablets and urine samples.
authors.affiliation: Department of Chemistry, Hangzhou University.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Peng
authors.forename: Z P
authors.initials: ZP
authors.lastname: Yang
authors.forename: R S
authors.initials: RS
authors.lastname: Lu
mesh_terms: D002749:Chlorprothixene / Q000032:analysis*; D004566:Electrodes
chemical_list: D002749:Chlorprothixene