title: [Selection by means of KB cells of substances and extracts potentially active in cancer chemotherapy].
abstract: Several synthetic, semi-synthetic and natural compounds as well as plant extracts were screened for their growth inhibition activity on KB cells. The most active ones were naphthoquinones and derivatives of pyrido [4,3-b]carbazole alkaloids, with inhibition dose (ID50) less than 4 micrograms/ml. Of the crude extracts of several plants screened, Vellozia caput-ardeae showed to be the most active.
authors.affiliation: Seção de Farmacologia, Instituto Biológico, São Paulo.
authors.forename: O C
authors.initials: OC
authors.lastname: Fávaro
authors.forename: M M
authors.initials: MM
authors.lastname: De Oliveira
authors.forename: M A
authors.initials: MA
authors.lastname: Rossini
authors.forename: C R
authors.initials: CR
authors.lastname: Kamakura
authors.forename: A V
authors.initials: AV
authors.lastname: Pinto
authors.forename: M do C
authors.initials: Mdo C
authors.lastname: Pinto
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007624:KB Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic
vernacular_title: Seleção por meio de células KB de substâncias e extratos potencialmente ativos em quimioterapia do câncer.