Prospective controlled study of androgen effects on red cell oxygen transport and work capacity in chronic hemodialysis patients.
Effects of androgens on red blood cell (RBC) oxygen transport, RBC metabolism and work capacity in chronic hemodialysis patients were evaluated in a prospective controlled study. Compared to control subjects, patients given nandrolone decanoate had a sustained fall in RBC ATP and a transient rise in RBC DPG but P50 values were unchanged. Despite increases in RBC mass of 16-44% on androgen therapy, exercise on the treadmill improved in only 1 patient and actually declined in 3 others. Thus, these preliminary observations suggest that androgens may not improve hemoglobin-oxygen transport and that androgen-induced increases in red cell mass may only balance increased tissue oxygen requirements produced by these anabolic hormones.
Hendler
E D
ED
Department of Medicine, Veterans Administration Medical Center, West Haven, Conn.
Solomon
L R
LR
D045930:Anabolic Agents / Q000627:therapeutic use*; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D004911:Erythrocyte Volume / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005080:Exercise Test; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D010100:Oxygen / Q000097:blood*; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate; D010100:Oxygen