[Hemodynamic adaptation during extracorporeal perfusion and arteriovenous extracorporeal CO2 removal].
During an animal study using five bastard dogs the hemodynamic relations during extracorporeal perfusion with an arteriovenous circuit and extracorporeal CO2 removal (ECCO2-R) were analyzed. We utilised a prototype circuit (Promed, West-Germany) which is by diminution and using silicon rubber adapted to the application in newborn. A silicon lung (Scimed, 0.8 m2, ECCO2-R) was used in the circuit. During the six hours perfusion period a main arterial blood pressure of 83 +/- 17 mmHg and an extracorporeal blood flow of 412 +/- 56 ml/min was found using arteriovenous perfusion via the femoral artery and vein. We found a statistical significant correlation (r = 0.66) between the main arterial blood pressure and the extracorporeal blood flow. Further more there was a significant correlation between the arterial PCO2 and the blood flow through membrane lung (r = 0.81). In conclusion our animal experiments approved the possibility of hemodynamic adaptation to an arteriovenous circuit as well as effectiveness of CO2 removal via such circuit.
Schmidt
S
S
Universitäts-Frauenklinik Bonn.
Hultquist
K A
KA
Bindl
L
L
Gorissen-Bosselmann
S
S
Bartlett
R H
RH
Krebs
D
D
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood*; D004285:Dogs; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D008567:Membranes, Artificial; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012828:Silicones
D008567:Membranes, Artificial; D012828:Silicones; D002245:Carbon Dioxide; D010100:Oxygen
Hämodynamische Adaptation während extrakorporaler Perfusion und Arteriovenösem ECCO2-R.