title: Childhood brain tumor: presentation at younger age is associated with a family tumor history.
abstract: In a registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p = 0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.
authors.affiliation: Harvard Medical School, Boston.
authors.forename: A
authors.initials: A
authors.lastname: Sussman
authors.forename: A
authors.initials: A
authors.lastname: Leviton
authors.forename: E N
authors.initials: EN
authors.lastname: Allred
authors.forename: C
authors.initials: C
authors.lastname: Aschenbrener
authors.forename: D F
authors.initials: DF
authors.lastname: Austin
authors.forename: F H
authors.initials: FH
authors.lastname: Gilles
authors.forename: E T
authors.initials: ET
authors.lastname: Hedley-Whyte
authors.forename: L N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: J L
authors.initials: JL
authors.lastname: Lyon
authors.forename: G M
authors.initials: GM
authors.lastname: Swanson
mesh_terms: D000367:Age Factors; D001932:Brain Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D008297:Male; D008527:Medulloblastoma / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D012042:Registries