title: Transfers of frozen-thawed human embryos in cycles stimulated by HMG.
abstract: A total of 130 transfers of frozen-thawed (F-T) human embryos was carried out after moderate ovarian stimulation with human menopausal gonadotrophin (HMG). Embryos were replaced 3 days after the spontaneous luteinizing hormone (LH) surge or 4 days if ovulation was induced by human chorionic gonadotrophin (HCG). Embryos were thawed a few hours prior to transfer. One-hundred-and-twenty-three transfers were effective and 23 pregnancies were achieved. The rate of ongoing pregnancies per transfer was 17.9% (22/123). The survival rate of embryos originating from cycles stimulated by a combination of an LHRH analogue and HMG in a long protocol (LA-HMG protocol) was significantly lower when compared with the rate of embryos retrieved from clomiphene citrate-HMG (CC-HMG protocol) stimulated cycles (52 versus 67%, P less than 0.05). When fresh embryos originated from cycles stimulated with an LHRH analogue and HMG in a short protocol (SA-HMG protocol), the survival rate was not affected (59 versus 67%, NS). Although the difference was not significant, the ongoing pregnancy rate per transfer according to the three protocols from which the embryos originated seemed to be better with the SA-HMG protocol: 16% with the CC-HMG protocol, 14.5% with the LA-HMG protocol versus 27.6% with the SA-HMG protocol. The success rate was independent of the number of F-T transferred embryos if at least one embryo with 100% intact blastomeres was replaced.
authors.affiliation: Laboratoire de Biologie de la Reproduction et du Développement and L'Hôpital Edouard Herriot Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Lornage
authors.forename: D
authors.initials: D
authors.lastname: Boulieu
authors.forename: C
authors.initials: C
authors.lastname: Mathieu
authors.forename: J F
authors.initials: JF
authors.lastname: Guerin
authors.forename: M C
authors.initials: MC
authors.lastname: Pinatel
authors.forename: R
authors.initials: R
authors.lastname: James
authors.forename: C
authors.initials: C
authors.lastname: Alvarado
mesh_terms: D015925:Cryopreservation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005615:Freezing; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction
chemical_list: D008596:Menotropins