Lipopolysaccharide-induced inhibition of gastric acid and pepsin secretion in rats.
We used male Wistar rats to determine the effects of lipopolysaccharide (LPS) on gastric secretion. After pylorus ligation, 24-h fasted rats received i.p. injections of different doses of LPS dissolved in sterile saline. The amounts of gastric acid and pepsin secreted were determined 2, 4 or 8 h after injection. Small doses of LPS (10-1000 ng/rat) significantly inhibited the release of both gastric secretants as compared with control animals, and this inhibitory effect of LPS on gastric secretion was dose-related. The gastric antisecretory effect of LPS was still evident 8 h after injection, indicating that this action of LPS was long-lasting. These results suggest that LPS might be involved in the regulation of gastric secretion under certain pathophysiological conditions such as acute bacterial infections.
Uehara
A
A
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Okumura
T
T
Okamura
K
K
Takasugi
Y
Y
Namiki
M
M
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D011708:Pylorus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology
D008070:Lipopolysaccharides; D010434:Pepsin A