title: Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin.
abstract: There were no statistically significant differences in final body weight or in food intake among groups of rats fed for 7 wk various fats of animal origin (lard fat and cod liver oil) or vegetable origin (corn, soybean and canola oils); the fats were fed as 10% of the diet (by wt) and were of varied fatty acid composition. Nevertheless, the mean weights of the kidneys from cod liver oil-fed animals were significantly higher than those of all other dietary groups. Platelets of rats from the groups receiving the animal fat contained significantly lower levels of linoleic acid, 18:2(n-6) [a precursor of arachidonic acid, 20:4(n-6)], than did platelets from rats receiving the fat of vegetable origin. Although the soybean-, canola- and cod liver oil-fed animals received substantial quantities of (n-3) fatty acids [alpha-linolenic acid, 18:3(n-3); eicosapentaenoic acid, 20:5(n-3); and docosahexaenoic acid, 22:6(n-3)], only the platelets of the latter two groups contained detectable levels of these fatty acids along with their products of elongation/desaturation/retroconversion. Platelets of the cod liver oil-fed group contained significantly less arachidonic acid, a major precursor of eicosanoids, than did those from all other dietary groups. However, platelet arachidonic levels also varied markedly among the other dietary groups. Diet-induced fatty acid changes observed in platelets of various dietary groups may influence platelet responses, including secretion, aggregation and biosynthesis of eicosanoids.
authors.affiliation: Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Piché
authors.forename: V G
authors.initials: VG
authors.lastname: Mahadevappa
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000032:analysis; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002849:Chromatography, Gas; D003060:Cod Liver Oil / Q000008:administration & dosage* / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage* / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000032:analysis; D005395:Fish Oils / Q000008:administration & dosage*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage* / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008041:Linoleic Acids; D010938:Plant Oils; D016718:Arachidonic Acid; D003060:Cod Liver Oil; D019787:Linoleic Acid