Biological activity of two photoactive benzocoumarins.
The effect on DNA synthesis in cell cultures exerted by two photoactive benzocoumarins were studied. A favourable ratio between inhibition of DNA synthesis and the irradiation time periods was found in these compounds. This activity is substantially due to their ability to produce a monofunctional adduct with DNA.
Dianzani
C
C
Institute of Pharmacology and Experimental Therapy, University of Turin, Italy.
Silvestro
L
L
Viano
I
I
D000818:Animals; D002478:Cells, Cultured; D003374:Coumarins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D011564:Furocoumarins / Q000494:pharmacology; D008730:Methoxsalen / Q000494:pharmacology; D014466:Ultraviolet Rays
D003374:Coumarins; D011564:Furocoumarins; C069509:3H-naphtho(2,1-b)pyran-3-one; D004247:DNA; C069508:9-(3-diethylaminopropyloxy)-3H-naphtho(2,1-b)pyran-3-one; C011659:angelicin; D008730:Methoxsalen