[Sensitivity of larvae of Drosophila melanogaster mutant mus(2)201G1 to various analgesics].
Sensitivity of larvae from mutagen-sensitive mus(2)201G1 mutant of Drosophila melanogaster to analgin, amidopyrine and antipyrine (4-64 mkmol/ml of medium) was studied. Relative frequency of flies homozygous for this mutation after combined development of homozygous and heterozygous flies in the medium with the analgetic was used as a criterion for larval sensitivity. It is shown that sensitivity of homozygotes was significantly higher than that of heterozygotes to all three analgetics. Relative sensitivity of homozygotes increased with the elevation of drugs concentration. The data obtained demonstrate the mutagenicity of the analgetics tested for Drosophila.
Mikheev
V S
VS
Imianitov
E N
EN
D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D004351:Drug Resistance; D007814:Larva / Q000187:drug effects / Q000235:genetics; D009154:Mutation
D000700:Analgesics; D000632:Aminopyrine; D004177:Dipyrone; D000983:Antipyrine
Analiz chuvstvitel'nosti lichinok mutanta mus(2)201G1 Drosophila melanogaster k nekotorym anal'getikam.