title: Potential of bifonazole for direct lethal action.
abstract: Time-kill type experiments were designed to assess the potential of bifonazole, a topical antifungal imidazole-containing drug, for its capacity to exert growth phase-dependent direct physicochemical lethal action against opportunistic yeast pathogens. Test organisms included two strains of Candida albicans and one of Candida parapsilosis. In contrast to the reference imidazole miconazole, which rapidly killed yeast cells in late lag to early logarithmic phase at concentrations between 10(-5) and 10(-4) M, bifonazole was inhibitory but not lethal. Bifonazole appears to lack a significant capacity for growth phase-dependent direct lethal action against Candida species.
authors.affiliation: VA Medical Center, Minneapolis, MN 55417.
authors.forename: W H
authors.initials: WH
authors.lastname: Beggs
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; C036596:bifonazole