[An acute experimental study on the combinations of aluminum and fluorine in various ratios].
The joint actions were assessed by four methods after male Wistar rats had been acutely intoxicated with nine proportional mixtures of Al and F. Strong antagonistic effects of Al on F were observed in the mixtures, in which the ratio of Al to F ranged from 0.8:0.2 to 0.1:0.9. The optimum ratio of Al to F for antagonism ranged from 0.3:0.7 to 0.1:0.9 without periorbital bleeding that was a regular finding in Al acute toxicity on the rat to be seen. When the amount of Al in the mixture was below 5% or above 90%, no antagonistic effect was shown. The kinetics on the absorption under the condition of Al and F existing simultaneously is still unknown, and warrants further investigation.
Li
D
D
Xiao
B
B
Dong
Q
Q
Li
S
S
Zhan
C
C
D000535:Aluminum / Q000494:pharmacology / Q000633:toxicity*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002712:Chlorides / Q000494:pharmacology / Q000633:toxicity*; D005459:Fluorides / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D005459:Fluorides