title: Monoclonal gammopathy and glomerulonephritis with organized microtubular deposits.
abstract: We report a case with IgG-kappa monoclonal gammopathy of unidentified significance (MGUS) and glomerulonephritis (GN) with organized microtubular deposits on electron microscopy (EM). Light microscopy (LM) examination showed exudative features and moderate extracapillary proliferation. An acute nephritic syndrome with a rapidly progressive renal failure was clinically manifest at the onset and during each relapse. The patient was treated with methylprednisolone pulses followed by oral prednisone, cyclophosphamide, plasmapheresis, and maintenance courses of chemotherapy. The response to treatment was good, with a temporary improvement of renal function and control of the downhill course over a 3-year follow-up.
authors.affiliation: Institute of Nephro-Urology, University of Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Rollino
authors.forename: R
authors.initials: R
authors.lastname: Coppo
authors.forename: G
authors.initials: G
authors.lastname: Mazzucco
authors.forename: D
authors.initials: D
authors.lastname: Roccatello
authors.forename: A
authors.initials: A
authors.lastname: Amore
authors.forename: B
authors.initials: B
authors.lastname: Basolo
authors.forename: G
authors.initials: G
authors.lastname: Martina
authors.forename: B
authors.initials: B
authors.lastname: Gianoglio
authors.forename: G
authors.initials: G
authors.lastname: Piccoli
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005921:Glomerulonephritis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008297:Male; D008870:Microtubules / Q000648:ultrastructure*; D010265:Paraproteinemias / Q000473:pathology* / Q000628:therapy
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains