Oxygen-transport fluid based on perfluorochemicals: effects on liver biochemistry.
The effects of (1) i.v. injection of various perfluorochemical (PFC) emulsions, (2) different fractions of the non-ionic poloxamer surfactant, Pluronic F-68, or (3) i.p. injection of component PFC oils have been studied separately in male and female rats. Injection of 10 ml/kg body wt of either Fluosol-DA 20% (F-DA) or a novel perfluorodecalin emulsion containing a C-16 oil additive in male rats increased liver weight up to 7 days later; no corresponding effect occurred in response to injection of Oxypherol (FC-43). Liver weight was also increased in female rats at 72 hr after injection of the novel emulsion but this was less pronounced than in males; liver weight in female rats was unchanged in response to injection of either F-DA or FC-43 but was 12% greater at 72 hr after injection of FDC oil. Mean liver microsomal cytochromes P-450 concentrations in male rats were increased 2-3 fold at 72 hr after injection of either FDC, F-DA or the novel emulsion; a less pronounced increase was also seen at 7 days in animals receiving the novel emulsion. No significant alterations in cytochromes activity occurred in response to injection of FTPA, FTBA, the C-16 oil, FC-43 or either commercial grade or purified pluronic solution. Liver cytochromes P-450 concentrations in female rats were unaffected by any of the experimental treatments.
Lowe
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KC
Department of Zoology, University of Nottingham, UK.
Armstrong
F H
FH
D000818:Animals; D001802:Blood Substitutes / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D006895:Hydroxyethyl Starch Derivatives; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C008807:perfluorotributylamine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D003577:Cytochrome P-450 Enzyme System