title: Prospective controlled study of androgen effects on red cell oxygen transport and work capacity in chronic hemodialysis patients.
abstract: Effects of androgens on red blood cell (RBC) oxygen transport, RBC metabolism and work capacity in chronic hemodialysis patients were evaluated in a prospective controlled study. Compared to control subjects, patients given nandrolone decanoate had a sustained fall in RBC ATP and a transient rise in RBC DPG but P50 values were unchanged. Despite increases in RBC mass of 16-44% on androgen therapy, exercise on the treadmill improved in only 1 patient and actually declined in 3 others. Thus, these preliminary observations suggest that androgens may not improve hemoglobin-oxygen transport and that androgen-induced increases in red cell mass may only balance increased tissue oxygen requirements produced by these anabolic hormones.
authors.affiliation: Department of Medicine, Veterans Administration Medical Center, West Haven, Conn.
authors.forename: E D
authors.initials: ED
authors.lastname: Hendler
authors.forename: L R
authors.initials: LR
authors.lastname: Solomon
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use*; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D004911:Erythrocyte Volume / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005080:Exercise Test; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D010100:Oxygen / Q000097:blood*; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis
chemical_list: D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate; D010100:Oxygen