Differentiation control in cell cycle and development based on the alterations of higher-order chromatin structure. Theory and applications to radiation and chemical action.
A theoretical model of genes switching during development and cell cycle is proposed. The model is based on the assumption concerning the connection between differentiation state and distribution of chromatin domains in the nucleus. Radiation and chemicals action as supposed in the model is realized not at the DNA secondary structure level, but by the damage of chromatin supramolecular states spectrum and transition probabilities between states.
Andreev
S G
SG
Department of Radiation Physics and Biophysics, Moscow Engineering Physics Institute, USSR.
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004249:DNA Damage; D005812:Genes, Switch; D006801:Humans; D008957:Models, Genetic; D008968:Molecular Conformation; D013816:Thermodynamics
D002843:Chromatin