Site-dependent action of intracerebroventricular 5-hydroxytryptamine on the cold-stimulated thyrotropin secretion in male rats.
The effects of central 5-hydroxytryptamine (5-HT) infusions on the cold-stimulated thyrotropin (TSH) levels were studied in male rats. Stainless-steel cannulas were implanted stereotaxically into the anterior or the posterior third ventricle or just lateral to the hypothalamic paraventricular nuclei bilaterally 7 days before experiments. Infusion of 5-HT (4.5 and 9 micrograms/rat) into the posterior third ventricle attenuated significantly the cold-stimulated TSH levels. Inversely, infusion of 5-HT (9 micrograms/rat) into the anterior third ventricle augmented significantly the TSH cold response. Bilateral 5-HT infusions into the vicinity of the hypothalamic paraventricular nuclei did not affect the TSH cold response. Serum prolactin levels increased significantly after 5-HT administration into the anterior and the posterior third ventricle, but no consistent effect on growth hormone (GH) levels could be detected. Infusion of 5-HT into the anterior and the posterior third ventricle decreased body temperature irrespective of the observed hormonal response to 5-HT. The results are in favor of a dual and possibly site-dependent role for 5-HT in the regulation of the cold-stimulated TSH secretion in the rat. The opposite effects of 5-HT on the TSH cold response may result from the predominant inhibition of either the thyrotropin-releasing hormone or the somatostatin-secreting cell groups.
Toivonen
M
M
Research Unit of Neurobiology, University of Helsinki, Finland.
Rauhala
P
P
Männistö
P T
PT
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002552:Cerebral Ventricles; D003080:Cold Temperature; D013006:Growth Hormone / Q000097:blood; D007263:Infusions, Parenteral; D008297:Male; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000008:administration & dosage / Q000502:physiology*; D013972:Thyrotropin / Q000378:metabolism*
D012701:Serotonin; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone