Simultaneous Doppler and thermodilution assessment of pulmonary artery flow during acute interventions in patients with chronic obstructive pulmonary disease.
Subcostal pulsed wave Doppler echocardiography of the right ventricular outflow tract was used to assess pulmonary arterial flow at basal conditions and during interventions in 20 patients with chronic obstructive pulmonary disease. The changes in the pulmonary flow induced by interventions ranged from -1.5 l/min to +4.18 l/min (73% to 183% of the basal value). When considered alone, heart rate changes induced by the interventions could explain 53% of the changes in pulmonary flow measured with thermodilution. When Doppler-assessed right ventricular stroke volume changes were also considered the coefficient of determination (R) increased to 77% (r = 0.88, p less than 0.001, SEE = 12%). Doppler echocardiography was less precise in predicting absolute basal values of pulmonary artery flow (r = 0.70, p less than 0.001, SEE = 1.00 l/min), probably indicating inaccurate assessment of the diameter of the right ventricular outflow tract.
Torbicki
A
A
Fondazione Clinica del Lavora, Medical Center Montescano, Pavia, Italy.
Tramarin
R
R
Fracchia
C
C
Mortara
A
A
Ambrosino
N
N
Pozzoli
M
M
Rampulla
C
C
Cobelli
F
F
D000286:Administration, Sublingual; D001783:Blood Flow Velocity / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D015150:Echocardiography, Doppler / Q000379:methods*; D005080:Exercise Test; D005541:Forced Expiratory Volume / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology* / Q000628:therapy; D009543:Nifedipine / Q000008:administration & dosage; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011651:Pulmonary Artery / Q000503:physiopathology*; D013815:Thermodilution / Q000379:methods*
D002245:Carbon Dioxide; D009543:Nifedipine; D010100:Oxygen