Insulin-like growth factor I (IGF-I) levels in follicular fluid from human preovulatory follicles: correlation with serum IGF-I levels.
Insulin-like growth factor I (IGF-I) levels were measured in both serum and fluid of preovulatory follicles (n = 156) in 43 women undergoing in vitro fertilization (IVF). The mean IGF-I level in follicular fluid (FF) was significantly lower than in serum (0.52 +/- 0.02 IU/L versus 0.66 +/- 0.23 IU/L), and FF levels were significantly correlated with individual serum IGF-I levels as well as with follicular size and FF volume but not with oocyte maturity, granulosa cell appearance, or IVF. This suggests that FF IGF-I levels cannot serve as a clinical indicator for the degree of oocyte/granulosa cell differentiation or a predictor for IVF. Serum IGF-I levels were inversely correlated with the number of human menopausal gonadotropin ampules administered during treatment, suggesting that IGF-I might enhance ovarian gonadotropic stimulation.
Rabinovici
J
J
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco 94143.
Dandekar
P
P
Angle
M J
MJ
Rosenthal
S
S
Martin
M C
MC
D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000032:analysis* / Q000502:physiology; D005498:Follicular Phase; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000032:analysis* / Q000166:cytology; D013002:Somatomedins / Q000032:analysis*
D013002:Somatomedins; D004958:Estradiol; D008596:Menotropins; D007334:Insulin-Like Growth Factor I