Abnormality of platelet membrane glycoprotein GPIIb in a myelodysplastic syndrome with 3q inversion presenting with marked dysmegakaryopoiesis.
Platelet membrane glycoproteins were analyzed in a case of myelodysplastic syndrome with inv(3) (q21q26) presenting with prominent dysmegakaryopoiesis by three different labelling techniques for surface proteins. Markedly decreased level of platelet membrane glycoprotein GPIIb was observed in the patient's platelets by terminal sialic acid labelling method, whereas no significant changes in the levels of glycoproteins including GPIIb could be detected either by penultimate galactose labelling or by tyrosine/histidine labelling. These results indicate a decreased sialylation of GPIIb in the patient's platelets, implying aberrant process in thrombopoiesis in the disease.
Yufu
Y
Y
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hashimoto
M
M
Muta
K
K
Ideguchi
H
H
Nishimura
J
J
Nawata
H
H
D001856:Bone Marrow Examination; D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005260:Female; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D007621:Karyotyping; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000235:genetics; D009784:Occupational Diseases / Q000097:blood / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000032:analysis*; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics; D013326:Strontium Radioisotopes / Q000009:adverse effects
D010980:Platelet Membrane Glycoproteins; D013326:Strontium Radioisotopes