Hepatic fibrosis: new insights into pathogenesis.
From available clinical and experimental data, the deterioration of hepatocellular function associated with fibrosis may be ascribed, in part, to loss of biologic support provided by a normal extracellular matrix. These studies of pathogenesis are expected to clarify new points of therapeutic intervention and also to rationalize empiric therapies.
Friedman
S L
SL
University of California, San Francisco, School of Medicine.
Bissell
D M
DM
D001485:Basement Membrane / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000166:cytology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000209:etiology* / Q000503:physiopathology