title: The mutations previously designated as flightless-I3, flightless-O2 and standby are members of the W-2 lethal complementation group at the base of the X-chromosome of Drosophila melanogaster.
abstract: By using a well defined panel of chromosomal deficiencies, duplications and lethals, we have mapped three mutations causing flightlessness, flightless-I3, flightless-O2 and standby, to a single lethal complementation group (termed W-2) at the base of the X-chromosome of D. melanogaster. We also show that a fourth flightless mutation, termed grounded, previously mapped near to the base of the X-chromosome, is distal to the cytogenetic interval 18F to 20F. Mutants homozygous for the flightless-I3, flightless-O2 and standby mutations exhibit abnormalities of myofibrillar arrangements in the indirect flight muscles. They have distorted Z-bands and the myofibrils are often displaced from their normal parallel arrangement. These viable flightless mutations are all hypomorphs since the homozygous deficiency of the W-2 X-chromosomal region is lethal to the organism.
authors.affiliation: Molecular Neurobiology Group, Research School of Biological Sciences, Australian National University, Canberra ACT.
authors.forename: G L
authors.initials: GL
authors.lastname: Miklos
authors.forename: H G
authors.initials: HG
authors.lastname: De Couet
mesh_terms: D000483:Alleles; D000818:Animals; D002503:Centromere / Q000648:ultrastructure; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005426:Flight, Animal; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D005838:Genotype; D008938:Mitosis; D009132:Muscles / Q000648:ultrastructure; D009154:Mutation; D014960:X Chromosome