Potential Shigella flexneri 2a and Shigella sonnei I live vaccinal strains. Characterization of immunogenicity in animal models.
Rats and rabbits were immunized intraintestinally with different doses of virulent and nonvirulent live Shigella flexneri 2a and Shigella sonnei I strains. The nonvirulent strains had one or two attenuating markers. The period of excretion with the faeces of the bacteria and of their polysaccharide antigens, the proliferation of antigen-binding and antibody-producing cells in the spleens and gut-associated lymphoid tissues and the levels of antibodies in sera and faeces were studied. Attenuated strains S. flexneri 2a 77 and S. sonnei I 3359 induced the most potent and long lasting local immune response.
Denchev
V
V
Institute of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Sumerska
T
T
Marinova
S
S
Vassilev
T
T
Panova
I
I
Linde
K
K
D000818:Animals; D000917:Antibody Formation; D001428:Bacterial Vaccines; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006801:Humans; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012763:Shigella flexneri / Q000276:immunology*; D012764:Shigella sonnei / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014611:Vaccination
D001428:Bacterial Vaccines