title: Longitudinal and cross-sectional studies of the relationship between 6-keto PGF1 alpha and high density lipoproteins.
abstract: Two studies were performed to examine the relationship between Prostacyclin (PGI2) and high density lipoprotein cholesterol (HDL-C). A longitudinal study examined the stable metabolite of PGI2, 6-keto PGF1 alpha, along with HDL-C, and total cholesterol (TC) before (Week 0), during (Week 4), and after (Week 9) an eight week aerobic conditioning program. 6-keto PGF1 alpha was measured by radioimmunoassay using 125I, and HDL-C and TC were spectrophotometrically analysed. Maximal oxygen uptake and resting heart rate data obtained at Week 0 confirmed that the training group (E) was not different from the sedentary group (C). Results obtained at Week 9 indicated that maximal oxygen uptake was higher (p less than 0.05) and resting heart rate lower (p less than 0.05) in the E group, while these variables remained unchanged in group C. Levels of 6-keto PGF1 alpha, HDL-C, and TC did not differ between groups E and C when Week 0 was compared with Week 9. However, within the E group, significantly lower concentrations of 6-keto PGF1 alpha (p less than 0.05) and HDL-C (p less than 0.05) were found at Week 4 compared with Week 0. A cross-sectional study involving 52 subjects examined the relationship between 6-keto PGF1 alpha and several cardiovascular disease risk factors which included HDL-C. The only significant correlation (r = 0.50 p less than 0.05) observed was between 6-keto PGF1 alpha and HDL-C.
authors.affiliation: Defence and Civil Institute of Environmental Medicine, Toronto, Ontario, Canada.
authors.forename: J D
authors.initials: JD
authors.lastname: Symons
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood; D003430:Cross-Sectional Studies; D011464:Epoprostenol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010101:Oxygen Consumption; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D015121:6-Ketoprostaglandin F1 alpha; D002784:Cholesterol; D011464:Epoprostenol