Genotoxicity of ethyl carbamate in the Drosophila wing spot test: dependence on genotype-controlled metabolic capacity.
Ethylcarbamate has a clear genotoxic potential in Drosophila melanogaster. In the somatic mutation and recombination test (SMART) it induces, in a dose-dependent manner, single spots as well as twin spots. The twin spots indicate a recombinogenic activity of ethyl carbamate. A strong strain difference demonstrates that the metabolic activation of ethyl carbamate to DNA binding metabolites most probably also in Drosophila involves cytochrome P450-dependent enzyme activities.
Frölich
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A
Institute of Toxicology, Swiss Federal Institute of Technology.
Würgler
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D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005260:Female; D005838:Genotype; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D014520:Urethane / Q000378:metabolism / Q000633:toxicity*; D014921:Wings, Animal
D009153:Mutagens; D014520:Urethane