Relief of chronic burning pain in Fabry disease with neurotropin.
Neurotropin, an extract from the inflamed skin of vaccinia virus-inoculated rabbits, was effective in the relief of sharp or burning pain induced by pyrexia, hot weather, bathing, or exercise in 2 siblings with Fabry disease. Neither neurotropin nor carbamazepine mono-therapy relieved the episodic colicky pain in 1 patient; however, therapy with both drugs eliminated the pain completely. This result suggests that the mechanisms underlying the analgesic actions of both drugs may be complementary in ameliorating the pain of Fabry disease, even though the mechanism underlying the pain has not been clearly elucidated.
Inagaki
M
M
Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
Ohno
K
K
Ohta
S
S
Sakuraba
H
H
Takeshita
K
K
D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D000795:Fabry Disease / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D010375:Pedigree; D011134:Polysaccharides / Q000627:therapeutic use*
D000700:Analgesics; D011134:Polysaccharides; D002220:Carbamazepine; C010491:neurotropin