Degenerative changes, DNA synthesis and mitotic activity in rat liver following single and repeated exposure to fenarimol.
Degenerative changes were observed in liver of rats treated with single and repeated doses of fenarimol (250 mg/kg body weight x day). Regenerative changes i.e. increase in: DNA synthesis, hepatic DNA, mitotic activity and number of binuclear hepatocytes, were also noted.
Palut
D
D
Department of Sanitary Toxicology National Institute of Hygiene, Warsaw, Poland.
Kopeć-Szlezak
J
J
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D011743:Pyrimidines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D005659:Fungicides, Industrial; D011743:Pyrimidines; D004247:DNA; C033789:fenarimol