Alterations of the endoalveolar surfactant after surgery with extracorporeal circulation.
In 10 patients who required extracorporeal circulation (ECC) during surgery, we studied the damage induced by surgery to the pulmonary surfactant and the effectiveness of ambroxol in preventing changes in the phospholipid pool. There were 5 control patients and 5 patients who were given 1 g/day of ambroxol on the 4 days prior to and the 4 days after surgery. To follow changes in phospholipid concentrations, bronchoalveolar lavage (BAL) was performed before surgery and 24 h and 8 days after ECC. Phospholipids were assayed in the BAL liquid by two-dimensional thin-layer chromatography. There were marked decreases in total phosphorus and quantitative alterations of individual phospholipid species in the surfactant of the control group, but not in the patients treated with ambroxol.
Marcatili
S
S
Department of Phthisiology, I Medical Faculty, University of Naples, Italy.
Guarino
C
C
Giannattasio
A
A
Marcatili
A
A
Festa
M
M
Cautiero
V
V
Marini
M G
MG
Pierfederici
P
P
Dell'Orso
S
S
Cotrufo
M
M
D000328:Adult; D000551:Ambroxol / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002855:Chromatography, Thin Layer; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D006801:Humans; D008171:Lung Diseases / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis; D011183:Postoperative Complications / Q000517:prevention & control*; D011663:Pulmonary Surfactants / Q000502:physiology*
D010743:Phospholipids; D011663:Pulmonary Surfactants; D000551:Ambroxol