Anti-tuberculous drugs and sideroblastic anaemia.
Two cases of sideroblastic anaemia associated with antituberculous therapy are reported. The first, in whom there was a constitutional chromosomal abnormality and peripheral neuropathy, recovered on withdrawal of isoniazid and pyridoxine treatment. The other, who had been given a four-drug combination including isoniazid and pyrazinamide and recovered on the withdrawal of isoniazid alone, highlights the increasing likelihood of this complication in patients treated for tuberculosis, since this drug combination has regained popularity in recent years.
Sharp
R A
RA
Department of Haematology, Ninewells Hospital, Dundee.
Lowe
J G
JG
Johnston
R N
RN
D000328:Adult; D000756:Anemia, Sideroblastic / Q000139:chemically induced*; D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular