Anticonvulsive properties of F1933 (dulozafone) on kindled seizures in the rat.
The anticonvulsive properties of a new compound: F1933 (Dulozafone) were investigated in the amygdala kindling model and compared with those of diazepam. Both drugs protected fully kindled rats against generalized seizures but failed to suppress partial ictal events (amygdala afterdischarges and limbic seizures). The anticonvulsive action of F1933, administered at the ED100, was nearly reversed by the specific antagonist of benzodiazepines receptors; R015-1788 (Flumazenil), suggesting that the effect of F1933 is mediated by this receptor. These results also emphasize the usefulness of kindling to test antiepileptic drugs and to confirm their supposed profile of action.
Lerner-Natoli
M
M
CNRS UPR 41, Laboratoire de Médecine Expérimentale, Montpellier, France.
Rondouin
G
G
Stenger
A
A
Briley
M
M
D000083:Acetanilides / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004558:Electric Stimulation; D005442:Flumazenil / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control*
D000083:Acetanilides; D000927:Anticonvulsants; D005442:Flumazenil; C065732:dulozafone; D003975:Diazepam