Exposure of rats to high concentrations of 1,1,1-trichloroethane and its effects on brain lipid and fatty acid composition.
Exposure of rats to 1,1,1-trichloroethane (TRI) (1200 p.p.m.) for 30 days resulted in changes in the fatty acid pattern of the brain ethanolamine phosphoglyceride. A decrease was observed in stearic acid (18:0) and arachidonic acid (20:4), while the 22-carbon (n-3) fatty acids were increased. These changes in the fatty acid pattern were similar to that observed previously in the rat for another solvent, perchloroethylene, at a lower exposure concentration (320 p.p.m). Both these solvents are little metabolised and it seems that a common mechanism exists whereby these solvents alter the fatty acid pattern of brain phospholipid upon exposure. The relatively low uptake of TRI makes a high exposure level (1200 p.p.m.) necessary to attain a blood concentration high enough for the changes to appear.
Kyrklund
T
T
Institute of Neurobiology, University of Göteborg, Sweden.
Haglid
K G
KG
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010714:Phosphatidylethanolamines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013750:Tetrachloroethylene / Q000097:blood / Q000633:toxicity; D014240:Trichloroethanes / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D014241:Trichloroethylene / Q000097:blood / Q000633:toxicity
D005227:Fatty Acids; D010714:Phosphatidylethanolamines; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D014241:Trichloroethylene; D013750:Tetrachloroethylene