Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses.
IgA isotype responses are regulated by at least two compartments including those of CD4+ Th2 type cells and cytokines produced by these cells. Interaction of CD4+ Th cells and APC via TCR and Ag-MHC II leads to activation of Th2 type cells. This would allow for secretion of cytokines, especially IL-5 and IL-6 which are key cytokines for the terminal differentiation of B cells into Ig secreting cells. Further, expression of Fc alpha RII on CD4+ Th2 cells could be important for the recruitment of sIgA+ B cells which would allow selective interactions of Th2 cells and sIgA + B cells via Fc alpha RII. This could lead to selectively transfer of IL-5 and IL-6 to sIgA + B cells from CD4+ Th2 cells.
Kiyono
H
H
Department of Oral Biology, Microbiology and Medicine, University of Alabama, Birmingham 35294.
Taguchi
T
T
Aicher
W K
WK
Beagley
K W
KW
Fujihashi
K
K
Eldridge
J H
JH
McGhee
J R
JR
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D011961:Receptors, Fc; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D016207:Cytokines; C036832:Fc(alpha) receptor; D007070:Immunoglobulin A; D011961:Receptors, Fc