Epidermal growth factor receptors and prognosis in primary breast cancer.
A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy). EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors.
Spyratos
F
F
Laboratoire des récepteurs hormonaux, Centre René Huguenin, Saint-Cloud, France.
Delarue
J C
JC
Andrieu
C
C
Lidereau
R
R
Champème
M H
MH
Hacène
K
K
Brunet
M
M
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005500:Follow-Up Studies; D005784:Gene Amplification; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012189:Retrospective Studies
D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors