title: Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.
abstract: Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.
authors.affiliation: Department of Genetics, Martin Luther University, Halle, DDR.
authors.forename: G
authors.initials: G
authors.lastname: Reuter
authors.forename: M
authors.initials: M
authors.lastname: Giarre
authors.forename: J
authors.initials: J
authors.lastname: Farah
authors.forename: J
authors.initials: J
authors.lastname: Gausz
authors.forename: A
authors.initials: A
authors.lastname: Spierer
authors.forename: P
authors.initials: P
authors.lastname: Spierer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics*; D006570:Heterochromatin; D008667:Metalloproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010766:Phosphorylation; D010858:Pigmentation / Q000235:genetics; D015183:Restriction Mapping; D013489:Suppression, Genetic
chemical_list: D004268:DNA-Binding Proteins; D006570:Heterochromatin; D008667:Metalloproteins; D004247:DNA