[The antitumor activity of Lactobacillus casei--the direct effects of L. casei to human tumor cell lines].
The effects of somatic components of Lactobacillus casei (L. casei) were studied on cell growth in vitro. L. casei was able to suppress the growth of MT-2, MT-4 cells from adult T-cell leukemia, Molt-4 cells from acute lymphoblastic leukemia and U-937 cells from promonocytic leukemia. This effect was obviously different from the cytotoxicity of Vinbrastin, an anti-cancer drug. Flow cytometric experiments employing BrdU-anti BrdU antibody demonstrated an increase of cells in G1 + G0 phases (pre-DNA synthesis phases) by the treatment of L. casei, therefore L. casei maybe acts as a low grade inhibitor of the protein synthesis. PC-treated L. casei had no more inhibition on cell growth than the non-treated one.
Katayama
Y
Y
Department of Microbiology, Osaka Medical College.
D002453:Cell Cycle; D006801:Humans; D007780:Lacticaseibacillus casei / Q000502:physiology*; D007938:Leukemia / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000382:microbiology / Q000473:pathology