Urticaria with macroglobulinaemia. Disease activity associated alterations in immunoglobulins profile and bone marrow hypodiploidy.
A case of chronic urticaria-like lesions with macroglobulinaemia (Schnitzler syndrome) is described. This case is unique by its double IgM monocomponents and by the follow-up study which shows immunoglobulins modifications between cutaneous flare-up and remission. As 1 case had a lymphoma, we studied the mononuclear cells of the bone marrow of Schnitzler syndrome to raise a possible malignant evolution of that disorder, and we discovered a hypodiploid population, which we compared with similar studies of myeloma and monoclonal 'benign' gammopathies.
Bonnetblanc
J M
JM
Department of Dermatology, CHU Dupuytren, Limoges, France.
Drouet
M
M
Laplaud
P
P
Bedane
C
C
Bernard
P
P
D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002908:Chronic Disease; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007963:Leukocytes, Mononuclear / Q000032:analysis; D014581:Urticaria / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology / Q000473:pathology
D007075:Immunoglobulin M; D007136:Immunoglobulins; D004247:DNA