High dose intact-immunoglobulin treatment for an HIV-infected asymptomatic carrier with hemophilia.
Intravenous administration of a high dose of intact-immunoglobulin to a human immunodeficiency virus (HIV) infected patient with hemophilia A, whose total lymphocyte and CD4 positive lymphocyte counts showed a decreasing tendency, resulted in a gradual rise in these cell counts. The results were quite reproducible on another occasions. Therefore, intravenous administration of gammaglobulin (IVGG) was thought to be effective for preventing further deterioration of cellular immunity and progression from asymptomatic carrier (AC) to AIDS related complex (ARC)/AIDS in hemophilia patients.
Akutsu
Y
Y
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Mori
K
K
Suzuki
S
S
Ishikawa
M
M
Sakai
H
H
D000328:Adult; D015658:HIV Infections / Q000150:complications / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007116:Immunization, Passive; D007143:Immunoglobulin Heavy Chains / Q000627:therapeutic use*; D007142:Immunoglobulin gamma-Chains / Q000627:therapeutic use*
D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains