Ivermectin binds avidly to plasma proteins.
Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.
Klotz
U
U
Dr. Margarete-Fischer-Bosch Institut für Klinische Pharmakologie, Stuttgart, FRG.
Ogbuokiri
J E
JE
Okonkwo
P O
PO
D001798:Blood Proteins / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007559:Ivermectin / Q000097:blood* / Q000493:pharmacokinetics; D011485:Protein Binding
D001798:Blood Proteins; D007559:Ivermectin