title: Treatment of anoestrous mares with a synthetic progestagen, allyloestrenol.
abstract: Anoestrous mares were treated with prostaglandin (n = 43) and those that did not respond to prostaglandin (n = 29) with a synthetic progestagen, allyloestrenol, at a dose of 0.05 mg/kg body mass for 12 days. After the cessation of the long-term per os gestagen blockade the animals were checked for heat and, if a preovulatory follicle could be palpated, 2000 IU hCG was administered to induce ovulation. In some animals the plasma 17 beta-oestradiol (E2) and progesterone (P4) levels were also followed up throughout the gestagen treatment and for 10-14 days thereafter. As the favourable oestrus rate (86.2%) and pregnancy rate (65.5%) indicate, the 12-day allyloestrenol treatment seems to be a reliable tool for induction of cycling in mares anoestrous early in the season. These results, supported by the E2 and P4 profiles, suggest that an important reason for anoestrus in mares is the absence of a functional corpus luteum that can be substituted for by exogenous gestagen administration. The timing of ovulation, however, should still be improved.
authors.affiliation: Department of Obstetrics and Reproduction, University of Veterinary Science, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Solti
authors.forename: K
authors.initials: K
authors.lastname: Eulenberger
authors.forename: D
authors.initials: D
authors.lastname: Kurth
authors.forename: L
authors.initials: L
authors.lastname: Schöne
mesh_terms: D000500:Allylestrenol / Q000494:pharmacology*; D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D004973:Estrus Synchronization / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D010062:Ovulation Induction / Q000662:veterinary; D011453:Prostaglandins / Q000494:pharmacology
chemical_list: D011453:Prostaglandins; D000500:Allylestrenol