Clinical use of the determination of serotonin in whole blood.
Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the whole-blood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used.
Kremer
H P
HP
Psychiatric Hospital Endegeest, Oegstgeest, The Netherlands.
Goekoop
J G
JG
Van Kempen
G M
GM
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D003907:Dexamethasone / Q000494:pharmacology; D016666:Fluvoxamine; D006801:Humans; D008297:Male; D010091:Oximes / Q000627:therapeutic use; D012701:Serotonin / Q000097:blood*; D014191:Tranylcypromine / Q000627:therapeutic use
D010091:Oximes; D012701:Serotonin; D014191:Tranylcypromine; D003907:Dexamethasone; D016666:Fluvoxamine