Conformational comparison in the growth hormone family.
1. The method of Kubota et al. [Biochim. biophys. Acta 701, 242-252 (1982)] was applied to several members of the growth hormone family in order to examine their conformational homology. 2. The method neither detects differences between rat, cow, sheep, horse and alpaca hormones, nor between monkey and human hormones. 3. Lack of homology between primate and non-primate growth hormones was found in segments 42-49 and 184-191. The first fragment could be linked to species-specificity.
Rivero
J L
JL
Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
Cascone
O
O
Biscoglio de Jimenez Bonino
M J
MJ
D000818:Animals; D002161:Camelids, New World; D002417:Cattle; D013006:Growth Hormone; D000882:Haplorhini; D006736:Horses; D006801:Humans; D011487:Protein Conformation; D051381:Rats; D013045:Species Specificity
D013006:Growth Hormone