title: Antiparkinsonian activity and dopamine receptor binding studies of imidazolone derivatives.
abstract: Mannich bases and styryl derivatives of imidazolones were evaluated for their antiparkinsonian activity. Two compounds showed potent antiparkinsonian activity. These active compounds also showed binding with dopamine receptors in striatal membrane preparation of rat brain.
authors.affiliation: Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Naithani
authors.forename: V K
authors.initials: VK
authors.lastname: Srivastava
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: J P
authors.initials: JP
authors.lastname: Barthwal
authors.forename: T K
authors.initials: TK
authors.lastname: Gupta
authors.forename: K
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents; D005260:Female; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*
chemical_list: D000978:Antiparkinson Agents; D007093:Imidazoles; D011954:Receptors, Dopamine