[Ultrastructural changes in the body wall and gut of Clonorchis sinensis in rats after albendazole treatment].
The effect of albendazole on the body wall and gut of Clornorchis sinensis was studied with transmission and scanning electron microscopes after albendazole administration to rats infected with Chonorchis sinensis at a single dose of 150 mg/kg. The results showed that swelling and adhesion of the projections of the tegument and gut microvilli occurred 1h after medication. Necrosis and disruption of the projections and the gut microvilli were seen at the 24th h. By the 72nd h, detachment of the partial projections were seen. The dynamic process of the damages observed on the tegument was identical with that of the gut microvilli (Figs. 1-10).
Li
B Z
BZ
Department of Parasitology, China Medical University.
Pang
X L
XL
Deng
L J
LJ
Yu
X H
XH
Zhang
Z W
ZW
Cao
Y M
YM
Liu
R D
RD
Zhang
F H
FH
Zhao
Y Y
YY
Su
R P
RP
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D003003:Clonorchiasis / Q000188:drug therapy / Q000469:parasitology*; D003004:Clonorchis sinensis / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D015766:Albendazole