Cardiovascular responses, hemodynamics and oxygen transport to tissue during moderate isovolemic hemodilution in pigs.
In conclusion, in contrast to many reports obtained from dogs, in pigs the rise in CO during moderate isovolemic hemodilution is, besides the increased venous return, more induced by increased work performance of the heart and less by a decreased SVR. The rise in CO did not compensate for the decrease in oxygen transport capacity. Our results confirm most of the reported findings in humans at the same stage of hemodilution. Besides changes in hemodynamics, in our study a gradual decreased oxygen affinity of hemoglobin could be observed. That the pig animal model for studying hemodilution and oxygen transport to the tissue is more appropriate than the dog model is open to discussion.
Trouwborst
A
A
Department of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
Tenbrinck
R
R
Fennema
M
M
Bucx
M
M
van der Broek
W G
WG
Trouwborst-Weber
B K
BK
D000818:Animals; D001693:Biological Transport, Active; D001810:Blood Volume / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006438:Hemodilution / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D013552:Swine; D014655:Vascular Resistance / Q000502:physiology
D006454:Hemoglobins; D010100:Oxygen