A three-year evaluation of hemostatic function in Singaporean Norplant-2 rod acceptors.
A longitudinal study of hemostatic function was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraception. The results at the end of three years indicate a possible increased predisposition to thrombosis, as evidenced by significant increases in platelet count and aggregability. The prothrombin time (PT) and activated partial thromboplastin time (APTT) continued to remain shortened at the end of three years of use. There was also a general fall in most of the vitamin K coagulation factors. There is thus still an indication of a possible enhanced potential for hypercoagulation at the end of three years of Norplant-2 rod use.
Singh
K
K
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Viegas
O A
OA
Ratnam
S S
SS
D003271:Contraceptive Agents, Female / Q000009:adverse effects / Q000494:pharmacology*; D004343:Drug Implants; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel; D008137:Longitudinal Studies; D009644:Norgestrel / Q000009:adverse effects / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D012846:Singapore; D013923:Thromboembolism / Q000139:chemically induced*
D003271:Contraceptive Agents, Female; D004343:Drug Implants; D009644:Norgestrel; D016912:Levonorgestrel