title: [Absence of various manifestations of adaptive response in Bacillus subtilis transformants].
abstract: Competent cells of Bacillus subtilis are more sensitive to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) than total population, exhibit higher level of spontaneous mutations to kanamycin resistance. However, the absolute number of mutated transformants doesn't rise with MNNG treatment in the range of 5 to 50 micrograms per ml. The adaptation to low concentrations of MNNG affects neither spontaneous nor MNNG-induced mutagenesis in the competent (transformed) cells, in contrast to their resistance which is stronger for the adapted transformants. The transformation by MNNG-treated plasmid pUB 110 doesn't reveal any difference between adapted and non-adapted cultures in transformation efficiency decline.
authors.forename: S V
authors.initials: SV
authors.lastname: Zherebtsov
mesh_terms: D000220:Adaptation, Biological; D001412:Bacillus subtilis / Q000235:genetics* / Q000502:physiology; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009154:Mutation; D010957:Plasmids; D014169:Transformation, Bacterial
chemical_list: D008769:Methylnitronitrosoguanidine
vernacular_title: Otsutstvie nekotorykh proiavleniĭ adaptivnogo otveta v transformantakh Bacillus subtilis.