[The radiation sensitizing activity of metronidazole and iso-metronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole)].
The effect of irradiation, metronidazole and iso-metronidazole on survival and number of tumor cells was analysed in vitro in mice that were inoculated with La-hemocytoblastosis--or Ehrlich-ascites-tumor cells after processing. It was shown that metronidazole and iso-metronidazole nearly have the same radiosensitizing activity on these conditions. The effect was dependent on concentration of compounds and cell type. With intraperitoneal application the iso-metronidazole was eliminated from Lewis-lung-carcinoma more slowly than from blood.
Proskurjakov
S J
SJ
Labor für Molekularbiologie, AdmW, UdSSR, Obninsk.
Smoryzanova
O A
OA
Rjabcenko
N I
NI
Dedenkov
A N
AN
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D066298:In Vitro Techniques; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; C031624:isometronidazole
Die radiosensibilisierende Aktivität von Metronidazol und iso-Metronidazol (1-(2-Hydroxyäthyl)-2-Methyl-4-Nitroimidazol).