Studies on structures of some platinum complexes with 1,1-cyclopropanedicarboxylate.
The crystal structures of [Pt(NH3)2CPrDCA].H2O (I), [Pt(CH3NH2)2CPrDCA] (II), and [Pt(dmbn) CPrDCA].2.5H2O (III) (where CPrDCA is 1,1-cyclopropanedicarboxylate; dmbn is 2,3-dimethyl-2,3-butyldiamine) are determined. Compound I crystallizes in the orthorhombic space group Pnma with the cell dimensions: a = 6.517(2), b = 9.709(3), c = 14.205(5) A, Z = 4, R = 0.058. Compound II is monoclinic with space group P2(1)/n, a = 9.648(3), b = 8.720(2), c = 12.770(4) A, beta = 107.12(2), Z = 4, R = 0.059. Compound III belongs to the monoclinic system space group P2(1)/m with the cell dimensions: a = 6.494(1), b = 19.638(3), c = 6.606(1)A, beta = 94.44(1), Z = 2, R = 0.038. Electronic structures of the complexes are studied and the correlation between structure of the amine ligands and biological activity of the complexes is explored.
Dong
Y H
YH
Coordination Chemistry Institute, Nanjing University, PRC.
Feng
J C
JC
Huang
Z Y
ZY
Tang
W X
WX
Dai
A B
AB
Zhou
Z Y
ZY
Yu
K B
KB
D000970:Antineoplastic Agents / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003998:Dicarboxylic Acids; D009944:Organoplatinum Compounds; C069173:1,1-cyclopropanedicarboxylate