title: Uranyl ion-catalyzed synthesis of several 8-substituted 2'-5'-oligoadenylates, and their properties.
abstract: We have synthesized 2'-5' linked oligomers from 8-substituted adenosine-5'-phosphorimidazolides using uranyl ion catalyst. 8-amino derivative, as highly susceptible to hydrolysis, gave short chained oligomers in a low yield, while the rest of 8-substituted or unsubstituted derivatives gave the corresponding oligomers in high yields. Properties of 8-substituted 2'-5' oligomers were studied applying spectrometer and through enzymatic digestion.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Sawai
mesh_terms: D000227:Adenine Nucleotides / Q000737:chemistry; D000241:Adenosine / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009843:Oligoribonucleotides / Q000737:chemistry; D011108:Polymers; D014501:Uranium / Q000737:chemistry*
chemical_list: D000227:Adenine Nucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; D011108:Polymers; D014501:Uranium; C023505:2',5'-oligoadenylate; D000241:Adenosine