Hepatic drug conjugation/deconjugation systems in hepatosplenic schistosomiasis.
The biotransformation capacity of the liver is altered in hepatosplenic schistosomiasis being more in favor of deconjugation pathways. These alterations should be considered when xenobiotics are administered and in studies of hepatic toxicity and carcinogenicity.
el Mouelhi
M
M
Pharmacology Department, Faculty of Medicine, Assiut University, Cairo, Egypt.
Mansour
M M
MM
D000818:Animals; D001711:Biotransformation; D005966:Glucuronidase / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006099:Granuloma / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012555:Schistosomiasis mansoni / Q000201:enzymology*; D013154:Spleen / Q000201:enzymology; D013429:Sulfatases / Q000378:metabolism; D015238:Sulfotransferases / Q000378:metabolism
D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D015238:Sulfotransferases; D013429:Sulfatases; D005966:Glucuronidase