Antitumor effect of liposome-entrapped adriamycin administered via the portal vein.
We examined the distribution in tissues and antitumor effect of freeze-dried liposome-entrapped adriamycin (Lipo-ADM) administered via the portal vein to rabbits bearing VX2 tumors. Liposomes composed of egg phosphatidylcholine (cholesterol 50 mol%) were used as drug carriers. The liver concentration of ADM increased after delivery and cardiac uptake decreased compared with free drug treatment. The in vivo antitumor effect of Lipo-ADM was determined in rabbits inoculated with VX2 tumor. Repeated injections of free ADM via the portal vein prolonged the life span of tumor-bearing rabbits. The life span was further prolonged by Lipo-ADM treatment compared with the control group and the free ADM group. Histological examination revealed that the damage to the liver caused by Lipo-ADM administered via the portal vein did not differ from that observed in animals treated with free ADM. These results indicate that portal vein administration of Lipo-ADM may be more effective in dealing with liver metastases than treatment with free ADM and may be therapeutically useful without toxic side effects.
Ichino
T
T
First Department of Surgery, Nagoya City, University Medical School.
Yotsuyanagi
T
T
Mizuno
I
I
Akamo
Y
Y
Yamamoto
T
T
Saito
T
T
Kurahashi
S
S
Tanimoto
N
N
Yura
J
J
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers; D007275:Injections, Intravenous; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009368:Neoplasm Transplantation; D011169:Portal Vein; D011817:Rabbits; D014018:Tissue Distribution
D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase