Iron overload in untransfused patients with hemoglobin H disease.
Two Chinese patients with hemoglobin (Hb) H disease without a history of blood transfusion developed iron overload at the age of 45 and 53 years, respectively. Human leukocyte antigen (HLA) system types of these 2 patients were A19, A11, B13, B62 and A2, A24, BW55, respectively, which are not related to the common haplotypes for idiopathic hemochromatosis. Since severe iron loading is a rare clinical manifestation in untransfused patients with Hb H disease, the iron overload in both patients may be due to environmental or underlying genetic factors.
Lin
C K
CK
Division of Hematology, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Peng
H W
HW
Ho
C H
CH
Yung
C H
CH
D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000235:genetics / Q000378:metabolism*
D007501:Iron