[Relations between overweight, thrombophilia and cardiovascular risk].
Seventy-one healthy subjects, aged 20 to 60, 19 males and 52 females, body mass index (BMI) 19 to 40, were enrolled in the study. None of them were smokers, or affected by hyperlipidemia, arterial hypertension or impaired glucose tolerance. We measured plasminogen activators inhibitor (PAI) activity, C-peptide levels, plasma fibrinolytic activity. We found a correlation between BMI and plasma fibrinolytic activity (r = -0.382, p less than 0.005), between BMI and PAI (r = 0.353, p less than 0.005), between BMI and C-peptide (r = 0.694, p less than 0.001) and between PAI and C-peptide (r = 0.404, p less than 0.02). Our data show a correlation between obesity and low fibrinolytic activity, probably due to high PAI levels. In obesity impaired fibrinolytic activity, maybe linked to hyperinsulinemia, could induce thrombophilic state.
Craveri
A
A
Corso Pareggiato di Semeiotica Medica dell'Università degli Studi di Milano, Ospedale San Paolo.
Tornaghi
G
G
Ranieri
R
R
Paganardi
L
L
D000328:Adult; D002096:C-Peptide / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors / Q000097:blood; D015849:Plasminogen Inactivators; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications
D002096:C-Peptide; D015849:Plasminogen Inactivators; D010960:Plasminogen Activators
Relazione tra sovrappeso corporeo, trombofilia e rischio cardiovascolare.