Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.
The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acetylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system.
Nabeshima
T
T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Tohyama
K
K
Kameyama
T
T
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning; D001640:Bicuculline / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D011760:Pyrrolidinones / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology
D002491:Central Nervous System Agents; D011760:Pyrrolidinones; C058876:nefiracetam; D000431:Ethanol; D005442:Flumazenil; C036466:aniracetam; D002707:Chlordiazepoxide; D012601:Scopolamine; D001640:Bicuculline