[Further studies of the respiratory stimulating effect of thyrotropin releasing hormone in the human].
The results of animal experiments, neuroanatomical and neurophysiological investigations reported in the literature suggest a central influence of TRH on respiration. In a group of 18 test subjects receiving 400 micrograms of thyrotropin releasing hormone i. v., we were able to demonstrate a clear stimulation of respiration on the basis of lung function parameters. We observed a highly significant increase (p less than 0.001) in minute volume from 8.2 to 10.6 l/minute, and in the PETO2 from 101.5 to 109.8 mmHg. TRH administered via a peripheral vein can reach areas of the brain via preformed passages in the tissue around the ventricles, and thus exercise an effect on the central respiration centres. Additional peripheral influences may be assumed.
Nink
M
M
III. Medizinische Klinik-Schwerpunkte, Universitätsklinikum Mainz.
Krause
U
U
Heuberger
W
W
Huber
I
I
Lehnert
H
H
D000328:Adult; D006801:Humans; D007262:Infusions, Intravenous; D008176:Lung Volume Measurements; D008297:Male; D010100:Oxygen / Q000097:blood*; D012119:Respiration / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D010100:Oxygen
Weitere Untersuchungen über die atemstimulierende Wirkung von Thyreotropin Releasing Hormon (TRH) beim Menschen.