title: Serum interleukin 6, C-reactive protein and pancreatic secretory trypsin inhibitor (PSTI) as acute phase reactants after major thoraco-abdominal surgery.
abstract: We measured serum immunoreactive interleukin 6 (IL-6) levels in patients after major thoraco-abdominal surgery and compared them with changes in serum C-reactive protein (CRP) and pancreatic secretory trypsin inhibitor (PSTI) levels. Serum IL-6 levels were elevated earlier than serum CRP or PSTI. There were significant relationships between the peak levels of serum IL-6 and the operation time (p less than 0.05) or the volume of blood loss during surgery (p less than 0.05), showing that serum IL-6 can be a useful laboratory test for the evaluation of tissue injuries due to surgical intervention. Though there was a significant relationship between the peak levels of IL-6 and CRP (p less than 0.01), there was no relationship between the peak levels of IL-6 and PSTI.
authors.affiliation: Second Department of Surgery, Osaka University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: J
authors.initials: J
authors.lastname: Nishijima
authors.forename: Y
authors.initials: Y
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmachi
authors.forename: N
authors.initials: N
authors.lastname: Hiraoka
authors.forename: T
authors.initials: T
authors.lastname: Niinobu
authors.forename: K
authors.initials: K
authors.lastname: Uda
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D004938:Esophageal Neoplasms / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D010195:Pancreatitis / Q000601:surgery; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000601:surgery; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood*; D014361:Trypsin Inhibitors / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic; D002097:C-Reactive Protein