Corticosteroid regulation of gonadotropin secretion and induction of ovulation in the rat.
In the human polycystic ovarian syndrome, glucocorticoids have been demonstrated to have beneficial effects in inducing ovulation in a number of cases. These beneficial effects were assumed to be due to suppression of adrenal overproduction of androgens. However, the possibility exists that glucocorticoids may directly regulate gonadotropin secretion and thereby improve menstrual rhythm and ovulatory activity. Herein, we report that the corticoid, deoxycorticosterone, and the synthetic glucocorticoid, triamcinolone acetonide, like progesterone (P4), are able to induce luteinizing hormone and follicle-stimulating hormone surges and facilitate ovulation in the pregnant mare serum gonadotropin-primed rat. This effect is not shared by cortisol. Prolactin release was also stimulated by deoxycorticosterone, cortisol, and progesterone, but not by triamcinolone acetonide. Similar to progesterone, triamcinolone acetonide and deoxycorticosterone administration caused a loss of fluid retention in the uterus. This effect of triamcinolone acetonide and deoxycorticosterone may be related to progesterone action as opposed to anti-inflammatory action since cortisol had no effect on uterine fluid retention. These findings raise the possibility that the beneficial effects seen with glucocorticoids in inducing ovulation in polycystic ovarian syndrome may be due in part to their direct effects upon the release of gonadotropins.
Brann
D W
DW
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912-3000.
Putnam
C D
CD
Mahesh
V B
VB
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D014222:Triamcinolone Acetonide / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D000305:Adrenal Cortex Hormones; D006064:Gonadotropins, Equine; D003900:Desoxycorticosterone; D011374:Progesterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone