title: [Morpho-functional state of the spermatogenic epithelium in rats under chronic inhalation effects of dispersible 2K orange azo dye].
abstract: The article contains a morphofunctional evaluation of spermatogenic epithelium state in rats after chronic inhalation of Orange-25 disperse azo dye. The result of the study revealed gonadotoxic effects at both concentration levels 28.5 mg/m3 and 5.6 mg/m3, which manifested themselves through violations in the spermatozoa functional states and changes in the seminiferous epithelium morphometric indices. Judging from the affection of the blood, the concentration 28.5 mg/m3 can be considered toxic, and 5.6 mg/m3 can be regarded liminal. Thus, the gonadotoxic effect was a secondary one, as in male rats in both groups, a hemotoxic effect was revealed at toxic and liminal dosage concentrations.
authors.forename: S E
authors.initials: SE
authors.lastname: Khipko
authors.forename: L I
authors.initials: LI
authors.lastname: Paranich
authors.forename: V I
authors.initials: VI
authors.lastname: Zvezdaĭ
authors.forename: N A
authors.initials: NA
authors.lastname: Vashuk
authors.forename: L N
authors.initials: LN
authors.lastname: Iashina
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage / Q000633:toxicity*; D001557:Benzenesulfonates / Q000008:administration & dosage / Q000633:toxicity*; D004396:Coloring Agents / Q000008:administration & dosage / Q000633:toxicity*; D004848:Epithelium / Q000033:anatomy & histology; D008297:Male; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D013783:Textile Industry
chemical_list: D001391:Azo Compounds; D001557:Benzenesulfonates; D004396:Coloring Agents; C014722:2-naphthol orange
vernacular_title: Morfofunktsional'noe sostoianie spermatogennogo épiteliia krys pri khronicheskom ingaliatsionnom vozdeĭstvii azokrasitelia dispersnogo oranzhevogo 2K.