Formation and persistence of procoagulant and fibrinolytic activities in circulation after strenuous physical exercise.
Seven healthy male volunteers were subjected to exercise of short (STR; 1.7 km), middle (MTR; 4.8 km) and long (LTR; 10.5 km) term runs at a speed close to maximal capacity. Blood samples were drawn before, immediately after exercise and at intervals over the next 10 h. FVIIIR:Ag (von Willebrand factor) rose 2.2-3.2 fold and persisted at higher levels than baseline during the observation time. A spontaneous drop in FVII (p less than 0.03) was found immediately after STR (13.5 +/- 2.5%) and LTR (18.3 +/- 2.4%), whereas only a minor decrease (7.5 +/- 6.5%) occurred in MTR. The procoagulant activity of monocytes isolated from whole blood exposed to LPS showed a striking enhancement in STR and MTR. An immediate enhancement in fibrinolytic activity was found in all groups (p less than 0.03) assessed by increased plasma levels of t-PA and shortened whole blood clot lysis time (WBCLT). The transient shortening of WBCLT was succeeded by a tendency to prolongation of the lysis time. A 45-year old male differed markedly from the others by demonstrating an extreme and consistent prolongation of WBCLT. Thus, it has been speculated that strenuous exercise possibly makes a subject more susceptible to a thrombotic event.
Hansen
J B
JB
Institute of Medical Biology, University of Tromsø, Norway.
Wilsgård
L
L
Olsen
J O
JO
Osterud
B
B
D000328:Adult; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D001780:Blood Coagulation Tests; D015444:Exercise / Q000502:physiology*; D005167:Factor VII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013925:Thromboplastin / Q000378:metabolism; D013997:Time Factors; D014841:von Willebrand Factor / Q000378:metabolism
D001779:Blood Coagulation Factors; D008070:Lipopolysaccharides; D014841:von Willebrand Factor; D005167:Factor VII; D005340:Fibrinogen; D013925:Thromboplastin