Treatment of status asthmaticus--hormone changes before and after aminophylline i.v. drip therapy.
The treatment of status asthmaticus is one of the most important factors in controlling the patient with asthma attacks. We have studied hormone changes in status asthmaticus and considered what is the best treatment in the asthma attack condition in children. Antidiuretic hormone (ADH), renin activity, and aldosterone activity are elevated in severe asthma attack conditions, and these high levels are correlated with high levels in Wood's clinical score. It is theoretical that patients with dehydration and respiratory failure show such elevation in hormones, and it is well known that under such conditions beta 2-stimulant enhances renin production. From our study, it is concluded that beta 2-stimulant subcutaneous injection must be considered in status asthmaticus. In children, aminophylline i.v. drip therapy may be one of the best treatments in status asthmaticus.
Iikura
Y
Y
Department of Allergy, National Children's Hospital, Tokyo, Japan.
Kishida
M
M
Akasawa
A
A
Nagakura
T
T
Akimoto
K
K
Saito
H
H
Koya
N
N
Sasamoto
A
A
D000293:Adolescent; D000450:Aldosterone / Q000097:blood*; D000628:Aminophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012083:Renin / Q000097:blood*; D013224:Status Asthmaticus / Q000097:blood* / Q000188:drug therapy; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D000628:Aminophylline; D000450:Aldosterone; D012083:Renin