Immunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissues.
The theory of 'homing' mechanism has been proposed to explain the association of malignant lymphoma involving multiple sites of mucosa-associated lymphoid tissue (MALT). DNA rearrangement in the peripheral blood and bone marrow specimens of 20 patients with MALT lymphoma were studied utilizing JH and C beta gene probes, aiming to detect circulating lymphoma cells and unrecognized bone marrow involvement. Our search for malignant cells in the peripheral blood was unrewarding and the 'homing' theory remained unproven. However, the study of DNA rearrangement showed to be useful in determining the malignant nature of abnormal lymphoid aggregates found in the bone marrow of these patients.
Liang
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R
University Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Chan
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Chan
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TK
Todd
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Ho
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D000328:Adult; D001853:Bone Marrow / Q000032:analysis / Q000276:immunology*; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology; D009092:Mucous Membrane / Q000276:immunology
D015342:DNA Probes; D004273:DNA, Neoplasm