title: Allelic interactions at the shibire locus of Drosophila: effects on behavior.
abstract: This report describes a detailed behavioral study of four shi alleles, shits1, shits2, shits4, and shiST139, and their heteroallelic combinations. Flies of different heteroallelic combinations (shi/shi) were less sensitive to high temperature than the corresponding homozygotes. Among them, shits2/shits4 showed a striking reduction in temperature sensitivity. In contrast, different shi/+ heterozygotes were more severe in temperature sensitivity than the hemizygotes, Df/+. The hemizygous combinations of shi alleles over deficiency (shi/Df) were not completely lethal, with shits2 conferring distinctively higher and shits4 lower viability. A novel behavior, bang sensitivity, was also found in shi/Df. The results of allelic interactions suggest that the shi mutations examined appear to be antimorphic and that the shi gene products are likely to function in multimeric form.
authors.affiliation: Department of Biology, University of Iowa, Iowa City 52242.
authors.forename: Y T
authors.initials: YT
authors.lastname: Kim
authors.forename: C F
authors.initials: CF
authors.lastname: Wu
mesh_terms: D000483:Alleles; D000818:Animals; D001522:Behavior, Animal; D003433:Crosses, Genetic; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D009068:Movement; D009154:Mutation; D009424:Nervous System Physiological Phenomena; D013696:Temperature; D014732:Vibration; D014960:X Chromosome