Long-term plasma exchange via Cimino fistula in patients with hypercholesterolemia.
Two patients with familial hypercholesterolemia were treated by long-term plasma exchange via an arteriovenous Cimino shunt using unselective membrane separation. Cholesterol was lowered to 40 percent (+/-3) of peak levels by each procedure. Sieving coefficient was 0.76 (+/-0.12). With a mean exchange interval of 11 days (+/-2), the peak cholesterol levels decreased from 406 mg per dl (+/-28) to 322 mg per dl (+/-27), the LDL fraction from 338 mg per dl (+/-9) to 265 mg per dl (+/-25) whereas the HDL fraction remained unchanged at 28 mg per dl (+/-4). Electrocardiographic stress testing improved in the first patient after treatment for 12 months.
Passfall
J
J
Klinikum Steglitz, Medizinische Klinik, Berlin.
Keller
F
F
Arntz
H R
HR
D000328:Adult; D001166:Arteriovenous Shunt, Surgical; D002784:Cholesterol / Q000302:isolation & purification; D008076:Cholesterol, HDL / Q000302:isolation & purification; D008078:Cholesterol, LDL / Q000302:isolation & purification; D004562:Electrocardiography; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008567:Membranes, Artificial; D002784:Cholesterol