title: Synthesis and biological activity of novel carbocyclic nucleosides.
abstract: The syntheses of several novel carbocyclic nucleosides which incorporate the cyclopentene moiety of neplanocin A will be presented. These include modified pyrimidine derivatives of the very potent antitumor agent cyclopentenyl cytosine and carbocyclic analogues of the ketohexose nucleosides psicofuranine and psicofuranosyl cytosine.
authors.affiliation: Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: V E
authors.initials: VE
authors.lastname: Marquez
authors.forename: M
authors.initials: M
authors.lastname: Bodenteich
authors.forename: R R
authors.initials: RR
authors.lastname: Copp
authors.forename: B B
authors.initials: BB
authors.lastname: Lim
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry; D003562:Cytidine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D009705:Nucleosides; D003562:Cytidine; C045911:cyclopentenyl cytosine; C031096:neplanocin A; D000241:Adenosine; C014174:psicofuranine