Disseminated intravascular coagulation and myocardial infarction in a haemophilia B patient during therapy with prothrombin complex concentrates.
A case of disseminated intravascular coagulation (DIC) and fatal myocardial infarction in a haemophilia B patient is described. DIC occurred after 4 days of therapy with unactivated prothrombin complex concentrates during the post-operative period. Therapy with fresh frozen plasma, heparin and antithrombin III concentrates was started without efficacy; after autopsy myocardial infarction was evident.
Chistolini
A
A
Department of Human Biopathology, University La Sapienza, Rome, Italy.
Mazzucconi
M G
MG
Tirindelli
M C
MC
La Verde
G
G
Ferrari
A
A
Mandelli
F
F
D001779:Blood Coagulation Factors / Q000009:adverse effects* / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D002836:Hemophilia B / Q000150:complications / Q000188:drug therapy*; D006552:Hernia, Inguinal / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D011300:Preoperative Care
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates