title: [alpha 1-proteinase inhibitor in breast cancer].
abstract: Level of alpha 1-proteinase inhibitor (alpha 1-Pi) and antitryptic activity in blood serum were assessed in 167 patients with breast cancer and 30 cases of benign lesions. An increase in blood serum-alpha 1-Pi level was shown to be associated with tumor advancement but could not be regarded as a marker of cancer. Concentration of the inhibitor exceeded 8 mg/ml in 83.4% of cases with metastatic breast cancer but was as a rule, equal to or below that value in metastasis--free patients. Those two groups were prognostically different. Morphological analysis established a correlation between blood serum-alpha 1-Pi level, on the one hand, and grade of malignancy, degree of pathologic changes in tumor stroma and extent of lymph node involvement, on the other.
authors.forename: V P
authors.initials: VP
authors.lastname: Demidov
authors.forename: R I
authors.initials: RI
authors.lastname: Iakubovskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Karmakova
authors.forename: G I
authors.initials: GI
authors.lastname: Avdeev
authors.forename: A B
authors.initials: AB
authors.lastname: Komissarov
authors.forename: E E
authors.initials: EE
authors.lastname: Sorokin
authors.forename: T S
authors.initials: TS
authors.lastname: Kotova
mesh_terms: D001941:Breast Diseases / Q000175:diagnosis; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008207:Lymphatic Metastasis / Q000175:diagnosis; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: alfa1-Ingibitor proteinaz pri rake molochnoĭ zhelezy.