title: pH-dependent fluoride inhibition of catalase activity.
abstract: The inhibitory effects of fluoride on several catalases were examined over a range of pH conditions. Preparations of bovine-liver catalase were sensitive to fluoride under acidic conditions. Catalase activity associated with whole-cell preparations of Actinomyces viscosus NP 311A remained relatively constant between pH 3.0 and 8.0 and was inhibited by fluoride in a pH-dependent manner. Fluoride was also observed to enhance hydrogen peroxide killing of A. viscosus NP 311A under acidic pH conditions. Results suggest that some catalase enzymes, including those associated with common plaque bacteria, may be inhibited by fluoride in a pH-dependent manner.
authors.affiliation: University of Connecticut Health Center, Farmington.
authors.forename: E A
authors.initials: EA
authors.lastname: Thibodeau
authors.forename: T F
authors.initials: TF
authors.lastname: Keefe
mesh_terms: D000190:Actinomyces / Q000201:enzymology*; D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002417:Cattle; D003773:Dental Plaque / Q000382:microbiology; D006861:Hydrogen Peroxide; D006863:Hydrogen-Ion Concentration; D012969:Sodium Fluoride / Q000494:pharmacology*
chemical_list: D012969:Sodium Fluoride; D006861:Hydrogen Peroxide; D002374:Catalase