Gastrointestinal activities of a new pirenzepine-analog, nuvenzepine, in the cat.
Nuvenzepine, a new pirenzepine-analog, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. On ileal motor activity, the compound showed a potency 10 times greater than that of pirenzepine, and, although to a lesser extent, it was also active, unlike pirenzepine, on colonic stimulated motility. Furthermore, in conscious cats, nuvenzepine inhibited pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine. The observed differences between antisecretory and antispastic activities displayed by nuvenzepine and pirenzepine suggest that the new pirenzepine-analog may act on gastrointestinal functions through an additional non-anticholinergic mechanism.
Barocelli
E
E
Istituto di Farmacologia e Farmacognosia, Facoltà di Farmacia, Università di Parma, Italy.
Chiavarini
M
M
Gentile
A
A
Lavezzo
A
A
Impicciatore
M
M
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002415:Cats; D003106:Colon / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005769:Gastrointestinal Motility; D007082:Ileum / Q000187:drug effects; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D010890:Pirenzepine / Q000494:pharmacology
D001570:Benzodiazepinones; D010890:Pirenzepine; C064721:nuvenzepine; D010434:Pepsin A