Effects of a moderate dose of alcohol on blood lipids and lipoproteins postprandially and in the fasting state.
Effects of a moderate dose of alcohol on blood lipids and lipoproteins were studied in volunteers of two age groups (20-30 and 45-55 years), each consisting of eight healthy men. The alcohol (30 g in red port and wine) was consumed during a standard dinner. Two blood samples were drawn: one in the postprandial phase, and one the next morning after fasting overnight. In the postprandial phase, one hour after intake, alcohol increased high-density lipoprotein cholesterol (HDL-C) by 11.5%, triglycerides (TG) by 15.3% and apolipoprotein A2 (Apo-A2) by 7.3% (P = 0.002, P = 0.044 and P = 0.024, respectively). The increase in HDL-C appeared to be mainly attributed to the HDL2-C subfraction which increased by 15.3% (P = 0.066). Furthermore, the increases in HDL-C, HDL2-C and TG were more pronounced in the middle-aged men then in the young men. After fasting overnight the effects of alcohol had disappeared.
Veenstra
J
J
Department of Nutrition, TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Ockhuizen
T
T
van de Pol
H
H
Wedel
M
M
Schaafsma
G
G
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D016633:Apolipoprotein A-II; D001054:Apolipoproteins A / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism*; D000431:Ethanol / Q000493:pharmacokinetics; D005215:Fasting / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D016633:Apolipoprotein A-II; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004044:Dietary Proteins; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D000431:Ethanol