Lack of tumorigenicity of aminopyrine orally administered to B6C3F1 mice.
To test the tumorigenic potential of aminopyrine, an antipyretic analgesic, it was administered in drinking water at levels of 0 (control), 0.04 and 0.08% to 50 male and 50 female B6C3F1 mice for 100 weeks, and the mice were subsequently maintained without aminopyrine for a further 4 weeks. The most frequent types of tumor, in both treated and control groups, were hepatocellular tumor in male mice and malignant lymphoma/lymphoid leukemia in female mice. No statistically significant differences were observed in the incidences of these tumors between treated and control groups. The incidences of several other tumors in male and female mice also showed no statistically significant differences between treated and control groups. Therefore, no tumorigenic effect of orally administered aminopyrine in B6C3F1 mice was apparent in the present study.
Inai
K
K
Second Department of Pathology, Hiroshima University School of Medicine.
Kobuke
T
T
Fujihara
M
M
Yonehara
S
S
Takemoto
T
T
Tsuya
T
T
Yamamoto
A
A
Tachiyama
Y
Y
Izumi
K
K
Tokuoka
S
S
D000284:Administration, Oral; D000632:Aminopyrine / Q000633:toxicity*; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012977:Sodium Nitrite / Q000633:toxicity
D000632:Aminopyrine; D012977:Sodium Nitrite