Long-term parenteral nutrition in unrestrained nonhuman primates: an experimental model.
A freely mobile jacket and tether system was developed for the investigation of total parenteral nutrition (TPN)-induced metabolic bone disease and complications of prolonged TPN in 12 Macaca fascicularis nonhuman primates. The animals received TPN for 49 +/- 7 d (means +/- SEM), providing 82 +/- 2 kcal.kg-1.d-1. Serum glucose increased from 3.6 +/- 0.2 mmol/L at baseline to 8.3 +/- 1.9 mmol/L (p less than 0.01) during TPN, and serum albumin decreased from 38 +/- 1 g/L at baseline to 29 +/- 1 g/L (p less than 0.001) during 2.75% amino acid TPN and 30 +/- 2 g/L (p less than 0.01) during 5% amino acid TPN infusion. No significant changes were seen in serum prealbumin, total protein, bilirubin, alanine aminotransferase, and 5'-nucleotidase during TPN infusion. Major complications included catheter sepsis, hyperglycemia, diarrhea, and premature death in six animals. Thus, metabolic complications of prolonged TPN support may be investigated in a freely mobile nonhuman primate.
Friday
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Department of Medicine, University of Washington, Seattle 98195.
Lipkin
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D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism / Q000401:mortality; D002408:Catheters, Indwelling / Q000009:adverse effects; D003967:Diarrhea / Q000209:etiology; D004195:Disease Models, Animal; D006943:Hyperglycemia / Q000209:etiology; D007262:Infusions, Intravenous; D008252:Macaca fascicularis; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D018805:Sepsis / Q000209:etiology