title: Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay.
abstract: Hepatitis C virus (HCV) antibody was detected in 1499 donor sera by radioimmunoassay using an antigen expressed in yeast from a cDNA clone of the HCV genome. Eighteen samples over 4200 counts per minute (cpm) were considered to contain infectious HCV because these recipients developed typical posttransfusion non-A, non-B hepatitis after transfusion. The antibody-positive sera were all within the normal range of ALT levels. This assay system is thus useful for the screening for blood transfusion.
authors.affiliation: Department of Surgery, Tokyo National Chest Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Miyamura
authors.forename: Q L
authors.initials: QL
authors.lastname: Choo
authors.forename: M
authors.initials: M
authors.lastname: Houghton
authors.forename: G
authors.initials: G
authors.lastname: Kuo
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D006526:Hepatitis C / Q000382:microbiology / Q000517:prevention & control*; D006518:Hepatitis Viruses / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D011994:Recombinant Proteins / Q000032:analysis
chemical_list: D000914:Antibodies, Viral; D011994:Recombinant Proteins