Soluble interleukin-2 receptor in vitro production by mononuclear cells from Hodgkin patients.
Lymphocytes of patients with Hodgkin's disease have a deficient production of Interleukin-2. Recently, a soluble form of the receptor for IL-2 has been demonstrated in human sera and in vitro-stimulated culture supernatants from human T lymphocytes. In the present paper we report the production of soluble IL-2R from peripheral blood mononuclear cells in H.D. The unstimulated MNC of patients released more sIL-2R than controls. No difference was observed between PHA-stimulated MNC of patients and controls. These preliminary findings suggest that soluble IL-2R may be provide a new tool for the study of immunological dysregulation in H.D.
Caruso
C
C
Istituto di Patologia generale, Università di Palermo, Italy.
Modica
M A
MA
Candore
G
G
Di Giulio
C
C
Galluzzo
A
A
Giordano
C
C
Di Marco
P
P
Gebbia
V
V
Tamone Reyes
M
M
Citarrella
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis* / Q000187:drug effects
D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2