title: Inhibition of monoamine oxidase by esters and peptides of aromatic amino acids.
abstract: Methyl esters of aromatic a-amino acids, peptides with N-terminal tyrosine and C-terminal arginine, and amides of peptides with N-terminal aromatic amino acids all inhibit monoamine oxidases A and B from rat liver mitochondria with an IC50 of 0.2-3 mM.
authors.affiliation: Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR, Moscow.
authors.forename: V F
authors.initials: VF
authors.lastname: Pozdnev
authors.forename: V A
authors.initials: VA
authors.lastname: Pekkel'
authors.forename: L N
authors.initials: LN
authors.lastname: Aksenova
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D008996:Monoamine Oxidase Inhibitors; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D004952:Esters; D008996:Monoamine Oxidase Inhibitors; D009842:Oligopeptides