title: Treatment of scars and keloids with a cream containing silicone oil.
abstract: The clinical effect of silicone cream containing 20% of silicone oil was tested on 47 patients with hypertrophic scars and keloids. A silicone cream/occlusive dressing technique, quite similar in manner to silicone gel treatment, resulted in a remarkable improvement of scars and keloids in 9 of 11 cases (82%) whereas the simple application of the cream onto the scars and keloids of 36 cases resulted in only mild improvement in 8 (22%). Using the chi-square test, a statistically significant difference was seen between these two treatments (p less than 0.01). From these findings, we suggest that occlusion and hydration are the principal modes of action of the silicone gel sheet method and our silicone cream/occlusive dressing technique.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: K
authors.initials: K
authors.lastname: Sone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007627:Keloid / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D012827:Silicone Oils / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology
chemical_list: D012827:Silicone Oils