The pathogenesis of cholestasis.
How does cholestasis develop when there is no obvious obstruction, destruction, or malformation of bile ducts? Recent findings on bile formation and flow are reviewed, and two models of intrahepatic cholestasis are presented: one of rapid onset, which is bile acid induced, and the other of slow onset, which is estrogen induced. Potential clinical correlations are discussed.
Zimniak
P
P
Department of Internal Medicine, University of Arkansas College of Medicine, Little Rock.
Radominska
A
A
Lester
R
R
D001646:Bile / Q000502:physiology; D001647:Bile Acids and Salts / Q000502:physiology; D002779:Cholestasis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008102:Liver Circulation / Q000502:physiology; D008954:Models, Biological
D001647:Bile Acids and Salts