Acute changes in osmolality and renin and respiratory control of arterial PCO2 and [H+].
To investigate whether osmoreceptor mechanisms or the renin-angiotensin system might be involved in respiratory regulation of H+ homeostasis, plasma osmolality was acutely lowered by approximately 10 mOsm in 7 awake mongrel dogs by a gastric water load (20 ml.kg-1 distilled, deionized water). Plasma renin activity (PRA) was measured as an indicator of angiotensin II levels. During these studies PaCO2 and [H+]a reflected the spontaneous level of ventilation (VE); higher levels of VE were correlated with lower PaCO2 and [H+]a, indicating a nonchemical drive to breathe. Stimulation of ventilation to lower PaCO2 following the water load was positively correlated with increase in PRA and decrease in plasma osmolality, but not with change in osmolality alone. An increased VE, a decreased ventilatory response curve (VRC) threshold for PaCO2, and a lower PaCO2 occurred with increase in PRA. Conversely, a lower or acutely decreased PRA, due to administration of arginine vasopressin, was correlated with a lower VE, an increase in the VRC threshold for PaCO2, and a higher PaCO2. Ventilatory control of PaCO2 during acute lowering of osmolality may be related to a central inter-action between osmolality and the renin-angiotensin system.
Anderson
J W
JW
Department of Physiology, Queen's University, Kingston, Ontario, Canada.
Sarda
I R
IR
Jennings
D B
DB
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood*; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D009994:Osmolar Concentration; D010313:Partial Pressure; D010953:Plasma Volume / Q000502:physiology; D012083:Renin / Q000097:blood* / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D014667:Vasopressins / Q000494:pharmacology; D014692:Ventilation-Perfusion Ratio / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D014667:Vasopressins; D000804:Angiotensin II; D002245:Carbon Dioxide; D000803:Angiotensin I; D012083:Renin