[Anatomo-histopathological and immunological correlations in chronic hepatitis].
An immunohistological survey was made of cryostat liver sections from 30 patients: 17 adults and 13 children affected by chronic hepatitis were studied. Immunofluorescent techniques were used to determine the following: HBsAg, HBcAg, HDV, IgG, serum antibodies, B lymphocytes and CD4+, CD8+ and activated T lymphocytes. The tissue antibody response and the inflammatory infiltrate was more evident in CAH than in CPH. The prevalent cell subpopulation in HBV hepatitis is represented by CD8+ while in non-A non-B and autoimmune forms by CD4+. Furthermore, in histologically more serious forms 75% of the T cells were activated with respect to 25% in non active forms. The difference was statistically significant.
Navone
C
C
I Clinica Malattie Infettive, Università degli Studi di Genova.
Mazzarello
G
G
D000328:Adult; D001706:Biopsy; D002648:Child; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000276:immunology* / Q000473:pathology; D006526:Hepatitis C / Q000276:immunology* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
Correlazioni anatomo-istopatologiche ed immunologiche nell'epatite cronica.