Erythromycin induces expression of the chloramphenicol acetyltransferase gene cat-86.
The plasmid gene cat-86 specifies chloramphenicol-inducible chloramphenicol acetyltransferase in Bacillus subtilis. This gene, like the erythromycin-inducible erm genes, is regulated by translational attenuation. Here we show that cat-86 is also inducibly regulated by erythromycin. cat-86 does not confer resistance to erythromycin.
Rogers
E J
EJ
Department of Biological Sciences, University of Maryland Baltimore County, Catonsville 21228.
Lovett
P S
PS
D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics*; D001483:Base Sequence; D002701:Chloramphenicol / Q000494:pharmacology; D015500:Chloramphenicol O-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics*; D004790:Enzyme Induction; D004917:Erythromycin / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000187:drug effects*; D005809:Genes, Regulator; D007700:Kinetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010957:Plasmids; D014176:Protein Biosynthesis
D004917:Erythromycin; D002701:Chloramphenicol; D015500:Chloramphenicol O-Acetyltransferase