[Analgesic and anticonvulsive effect of midazolam via intrathecal administration in the rat].
We have studied analgesic and anticonvulsive effect of midazolam by means of tail-flick test and electroshock respectively. The drug was administered via cervical and lumbar intrathecally in chronically implanted rats. Total doses were 50, 125, and 250 microg. Control animals received 0.3125, 0.625, 1.25 and 2.5 mg intraperitoneally. Degree of sedation was also measured with a motor activity scale with the purpose of correlating sedation with analgesic and anticonvulsive effect. Tail-flick test was carried out 5 and 30 minutes after the administration of midazolam. Results showed that lumbar intrathecal midazolam has analgesic effect in tail-flick test whereas cervical intrathecal or intraperitoneal midazolam has no analgesic effect and shows a non significant hyperalgesic trend. Cervical intrathecal and intraperitoneal midazolam has anticonvulsive effect. As sedative effect of the administered doses increases, there was also a not significant trend to shorten latency period of tail-flick test and to increase anticonvulsive effect.
González-Darder
J M
JM
Departamento de Neurocirugía, Facultad de Medicina, Universidad de Cádiz.
Gómez-Cárdenas
E
E
Segura-Pastor
D
D
Carrasco
M S
MS
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004597:Electroshock; D007278:Injections, Spinal; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D000700:Analgesics; D000927:Anticonvulsants; D008874:Midazolam
Acción analgésica y anticonvulsionante del midazolam administrado por vía intratecal en la rata.