The role of membrane water permeability in characterization of pathologically altered human stomach tissues: NMR studies.
Comparative NMR studies of normal and pathologically altered human stomach tissues were performed on the basis of proton T1 relaxation time measurements in the presence of high external concentrations of relaxation (contrast) agents manganese ethylenediaminetetraacetic acid (Mn-EDTA) and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). Diffusion permeability of the cell membrane to water, Pd, was determined by measuring the longest proton T1 component sensitive to the exchange of water molecules through the cell membrane. Pathologically altered tissues showed substantially higher (2 to 10 times) average cell membrane permeabilities to water.
Srejić
R
R
Institute of General and Physical Chemistry, Belgrade, Yugoslavia.
Popov
D V
DV
Boricić
I
I
Zuvela
M
M
D002463:Cell Membrane Permeability; D003287:Contrast Media; D004492:Edetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis*
D003287:Contrast Media; D009942:Organometallic Compounds; D008345:Manganese; D004369:Pentetic Acid; D004492:Edetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA