[Acute severe dyspnea as a side effect of drugs. Report from the CHDM (Comprehensive Hospital Drug Monitoring)].
This "syndrome" has been observed in 4 of 23,935 in-patients registered in the years 1974-1987 in the Comprehensive Hospital Drug Monitoring (Bern/St. Gallen), with 6 reactions. Signs of an attack of bronchial asthma, laryngeal or pulmonary edema or a (heart-)circulatory event were not observed. Each patient was cyanotic and 3 had the feeling of impending death. The eliciting drugs were penicillin-G (twice) and cefazolin (once), given i.v.; iron dextran i.m. (once); pitressin tannate i.m. (once) and dicobalt edetate (Kelocyanor) i.v.(once). In each case the reaction started during or shortly after injection of the drug; the duration of the reaction in 5 of these events was 20-80 minutes. The pathomechanism could be a special form of anaphylactic reaction with acute pulmonary hypertension, comparable to IgE-induced anaphylaxis in the rabbit or aggregate anaphylaxis in the monkey or the dog. Further observations are needed for more detailed study.
Hoigné
R
R
Medizinische Klinik, Zieglerspital Bern.
Jaeger
M D
MD
Hess
T
T
Wymann
R
R
Müller
U
U
Galeazzi
R
R
Maibach
R
R
Künzi
U P
UP
D000208:Acute Disease; D000328:Adult; D001127:Arginine Vasopressin; D002437:Cefazolin / Q000009:adverse effects; D002614:Chelating Agents / Q000009:adverse effects; D003490:Cyanosis / Q000139:chemically induced; D064420:Drug-Related Side Effects and Adverse Reactions; D004417:Dyspnea / Q000139:chemically induced*; D004492:Edetic Acid / Q000009:adverse effects; D005260:Female; D006801:Humans; D007505:Iron-Dextran Complex / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000009:adverse effects; D014667:Vasopressins / Q000009:adverse effects
D002614:Chelating Agents; C016671:pitressin tannate; D014667:Vasopressins; D001127:Arginine Vasopressin; C028222:cobalt-ethylenediamine tetraacetic acid chelate; D007505:Iron-Dextran Complex; D004492:Edetic Acid; D002437:Cefazolin; D010400:Penicillin G
Akute schwere Dyspnoe als Medikamentennebenwirkung. Mitteilung aus dem CHDM (Comprehensive Hospital Drug Monitoring).