[Renal effect of isoflurane].
Isoflurane is a pentafluorinated methyl ether and can be metabolized to inorganic fluoride in man. Nephrotoxicity may be developed after it's administration. The present study was carried out to evaluate the effects of isoflurane on renal hemodynamic and excretory function in 15 patients. The systolic, diastolic and mean arterial pressure and renal function were measured before, during and after induction of anesthesia by isoflurane. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were estimated by the clearances of paraaminohippuric acid and inulin, respectively. The results showed that a slight reduction in systolic pressure but no significant change in diastolic and mean blood pressures were found during anesthesia. There were 30% and 50% reductions in RPF and GFR, respectively. The filtration fraction increased significantly. Simultaneous decreases in urine flow, absolute and fractional excretions of sodium, absolute excretion of potassium, osmolar clearance and free water reabsorption rate were observed during isoflurane anesthesia. However, the blood pressure and renal function returned to pre-anesthesia levels 30-60 minutes after termination of anesthesia. These data suggest that isoflurane induces renal depressive effect which is reversible and temporary.
Chou
Y P
YP
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center.
Huang
W C
WC
Chang
C L
CL
Lin
C Y
CY
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004573:Electrolytes / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects
D004573:Electrolytes; D007530:Isoflurane