In vitro and in vivo fluorescence monitoring of photosensitizers.
The use of steady state fluorescence spectroscopy in the detection and monitoring of potential photochemotherapeutic agents is examined. Problems associated with both in vitro and in vivo fluorescence measurements are investigated, and typical data are presented. Recent results on the use of fluorescence in pharmacokinetic studies are discussed, and the relative merits of in vitro vs. in vivo methods are outlined.
Pottier
R
R
Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, Ontario.
D000818:Animals; D011166:Porphyrins / Q000032:analysis* / Q000493:pharmacokinetics; D011838:Radiation-Sensitizing Agents / Q000032:analysis* / Q000493:pharmacokinetics; D013050:Spectrometry, Fluorescence / Q000379:methods
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents