title: Neonatal treatment with phenobarbital, zixoryn and chloramphenicol lack of imprinting effect of zixoryn on microsomal enzyme activities.
abstract: Two potent microsomal enzyme inducing agents, phenobarbital and flumecinol (Zixoryn) as well as the microsomal enzyme inhibitor chloramphenicol (Chlorocid) were given subcutaneously to newborn rats in the first 5 days of their life. Microsomal cytochrome P-450 and b5 content and various cytochrome P-450 and P-448 dependent enzyme activities were measured at the age of 20 weeks. Phenobarbital had positive imprint effect on aminopyrine N-demethylase activity in female and on aniline hydroxylase activity in male rats. Flumecinol had no imprint effect. Chloramphenicol had a positive imprint on aniline hydroxylase activity in male rats. Sex differences in microsomal enzyme activities were not affected by the xenobiotics used.
authors.affiliation: Postgraduate Medical School, I. Department of Medicine, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Vas
authors.forename: I
authors.initials: I
authors.lastname: Szabó
authors.forename: M
authors.initials: M
authors.lastname: Kurcz
authors.forename: J
authors.initials: J
authors.lastname: Bence
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001559:Benzhydryl Compounds; D002701:Chloramphenicol; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C016914:flumecinol; D010634:Phenobarbital