[Comparative evaluation of the significance of various criteria of virulence of Mycobacterium tuberculosis].
The results of different criteria analysis and their interrelation in evaluating M. tuberculosis virulence for guinea-pigs are shown. 6- and 12-week indices, as their infectivity, dissemination, splenic index and lifespan are studied. It was demonstrated that the virulence index correlated with the intensity of Mycobacterium reproduction in the guinea-pig organs. The indices of virulence and dissemination are not correlated with the contaminating dose of Mycobacteria as well as the animals' lifespan. It is recommended to analyse a quantitative characteristics of virulence by means of its index by killing the guinea-pigs 6 weeks after their infection.
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D000818:Animals; D015169:Colony Count, Microbial; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000472:pathogenicity*; D013997:Time Factors; D014376:Tuberculosis / Q000209:etiology / Q000382:microbiology* / Q000401:mortality; D014774:Virulence / Q000502:physiology; D014781:Viscera / Q000382:microbiology*
Sravnitel'naia otsenka znachimosti razlichnykh kriteriev virulentnosti tuberkuleznykh mikobakterii.