G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain.
We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.
Okada
F
F
Health Administration Center, Hokkaido University, Sapporo, Japan.
Crow
T J
TJ
Roberts
G W
GW
D000368:Aged; D001479:Basal Ganglia / Q000378:metabolism*; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism*
D019204:GTP-Binding Proteins