Fanconi's anemia: genetic and molecular aspects of the defect.
Several features of Fanconi's anemia (FA) are reported: relative inefficiency in the processing of DNA cross-links and monoadducts, hypomutability at the two loci analysed, complementation of the cytogenetic defect by cocultivation with mouse cells and homology of the FA group A with the mouse cellular mutant MCS attempts to clone and characterise a DNA fragment which complements the defect. The relation between observed features and predisposition to leukemia are discussed.
Moustacchi
E
E
Institut Curie, Biologie, URA 1292 du CNRS, Paris, France.
Guillouf
C
C
Fraser
D
D
Rosselli
F
F
Diatloff-Zito
C
C
Papadopoulo
D
D
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D004351:Drug Resistance; D005199:Fanconi Anemia / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005816:Genetic Complementation Test; D006801:Humans; D006822:Hybrid Cells; D007940:Leukemia L5178 / Q000235:genetics; D008647:Mesocricetus / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D016296:Mutagenesis; D014170:Transformation, Genetic
D004273:DNA, Neoplasm; D004247:DNA