title: Central nervous system effects of lactate infusion in primates.
abstract: The concentration of total lactate in cisternal fluid increased threefold, from 12.3 +/- 2.1 to 37.6 +/- 8.9 mg/dl, during a 20-min intravenous infusion of 1 M racemic sodium lactate (10 mEq/kg) in 3 anesthetized, mechanically ventilated baboons. Rises in cisternal lactate lagged behind arterial lactate increases, but occurred during the time interval in which susceptible humans typically panic in response to lactate infusion. Subsequent to cisternal lactate increases, cisternal pH and HCO3- concentration progressively increased during a 105-min interval following lactate infusion. No consistent changes in cisternal pCO2 occurred during or subsequent to lactate infusion. These preliminary findings fail to support the hypothesis that lactate-induced panic is mediated by increasing central nervous system pCO2. Instead, these data demonstrate that lactate can rapidly increase in the central nervous system during lactate infusion, suggesting new lines of investigation for studying the mechanisms responsible for lactate-induced panic.
authors.affiliation: Department of Psychiatry, University of Washington, Seattle.
authors.forename: S R
authors.initials: SR
authors.lastname: Dager
authors.forename: J M
authors.initials: JM
authors.lastname: Rainey
authors.forename: M A
authors.initials: MA
authors.lastname: Kenny
authors.forename: A A
authors.initials: AA
authors.lastname: Artru
authors.forename: G D
authors.initials: GD
authors.lastname: Metzger
authors.forename: D M
authors.initials: DM
authors.lastname: Bowden
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000139:chemically induced; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000134:cerebrospinal fluid; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid* / Q000494:pharmacology*; D019344:Lactic Acid; D010200:Panic; D010215:Papio / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid