Cerebral blood flow responses to inhaled carbon dioxide in schizophrenia.
Carbon dioxide (CO2) is a potent cerebrovasodilator; even mild changes in CO2 are associated with marked changes in cerebral blood flow (CBF). We measured CBF before and after 5% CO2 inhalation in 19 medicated patients with schizophrenia and 16 normal volunteers. Another group of 16 volunteers had 2 CBF measurements under resting conditions. Although both patients and controls showed marked CBF increase during CO2 inhalation, the CBF response was significantly less in the patients. Change in CBF per mm of CO2 was lower in the patients. The second group of controls did not show significant differences between the 2 resting CBF measurements.
Mathew
R J
RJ
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Wilson
W H
WH
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002245:Carbon Dioxide / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D002245:Carbon Dioxide