Role of estradiol in regulating ovarian follicular atresia in rhesus monkeys: a review.
The present studies show that estradiol-17B (E2) implanted s.c. in rhesus monkeys for 24 hours reliably induces atresia of the dominant follicle (DF). Analysis of contents of the atretic DF revealed a reduction in cell viability and levels of steroids. These atretogenic effects of E2 could be mimicked by local application, but were not reversed by exogenous gonadotropins. E2 also had a direct effect on inhibiting steroid secretion by follicle cells in vitro. From these studies, we concluded that the effect of E2 is exerted at least in part at the ovarian level; this suggests that estrogen produced locally by the DF could have a physiologic role in controlling atresia of other follicles.
Hutz
R J
RJ
Department of Biological Sciences, University of Wisconsin-Milwaukee.
Dierschke
D J
DJ
Wolf
R C
RC
D000818:Animals; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005496:Follicular Atresia / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008253:Macaca mulatta / Q000502:physiology*; D008954:Models, Biological; D009865:Oocytes / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects*; D011897:Random Allocation
D004343:Drug Implants; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone