title: [Production of human proteins in the blood of transgenic animals].
abstract: The human alpha 1-antitrypsin gene has been microinjected into rabbit embryos. A line of transgenic rabbits has thus been established. Human alpha 1-antitrypsin was found in the blood of transgenic animals at the concentration of 1 mg/ml plasma. The human protein was active and separable from its rabbit counterpart. This experiment demonstrates that it is possible to use blood from transgenic animals as a source of recombinant proteins.
authors.affiliation: Institut national de la Recherche agronomique, Jouy-en-Josas.
authors.forename: M
authors.initials: M
authors.lastname: Massoud
authors.forename: R
authors.initials: R
authors.lastname: Bischoff
authors.forename: W
authors.initials: W
authors.lastname: Dalemans
authors.forename: H
authors.initials: H
authors.lastname: Pointu
authors.forename: J
authors.initials: J
authors.lastname: Attal
authors.forename: H
authors.initials: H
authors.lastname: Schultz
authors.forename: D
authors.initials: D
authors.lastname: Clesse
authors.forename: M G
authors.initials: MG
authors.lastname: Stinnakre
authors.forename: A
authors.initials: A
authors.lastname: Pavirani
authors.forename: L M
authors.initials: LM
authors.lastname: Houdebine
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000097:blood*; D005260:Female; D005796:Genes / Q000235:genetics; D006801:Humans; D008297:Male; D011817:Rabbits; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: La production de protéines humaines dans le sang d'animaux transgéniques.