Frequency of the -alpha 3.7 thalassemia deletion in the non-white Cuban population.
DNA analysis of the alpha-globin gene cluster showed that the frequency of the -alpha 3.7 deletion in the non-white cuban population is about 0.12, in agreement with a 47% admixture of the original African slaves introduced in the island. In the S-S homozygotes the frequency is slightly higher (.18), probably due to a selective advantage produced by the presence of alpha-thalassemia in sickle cell patients.
Martinez
G
G
Instituto de Hematologia e Inmunologia, La Habana, Cuba.
Ferreira
R
R
Hernandez
A
A
Di Rienzo
A
A
Felicetti
L
L
Colombo
B
B
D000755:Anemia, Sickle Cell / Q000150:complications / Q000235:genetics; D044383:Black People / Q000235:genetics; D002872:Chromosome Deletion; D003462:Cuba; D004247:DNA / Q000032:analysis; D005787:Gene Frequency; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D005810:Multigene Family; D013789:Thalassemia / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics
D005914:Globins; D004247:DNA