title: The identification of polyoxyethylene glycols and related compounds by capillary gas chromatography.
abstract: A sample work-up method for gas chromatographic profiling of polyoxyethylene glycol (PEG)-related compounds in pharmaceutical matrices is described. After a short sample clean-up, carbon-oxygen linkages are partially cleaved with 0.07 M boron tribromide in dichloromethane at room temperature. The reaction is stopped after 1 min by addition of 0.01 M HCl. The products are trimethylsilylated and injected onto a WCOT 50 m x 0.25 mm CP-SIL 5 CB fused silica column. Eleven model compounds, representing four common types of PEG-derivatives, have been evaluated by this method. The results show that characteristic profiles can be obtained from PEG-derivatives carrying different functional groups. Minimum detectable amounts are in the range of 200 micrograms.
authors.affiliation: Laboratory of Drug Analysis, Dr L. Willems-Instituut, Diepenbeek, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Leyssens
authors.forename: V
authors.initials: V
authors.lastname: Martens
authors.forename: E
authors.initials: E
authors.lastname: Royackers
authors.forename: H
authors.initials: H
authors.lastname: Penxten
authors.forename: A
authors.initials: A
authors.lastname: Verheyden
authors.forename: J
authors.initials: J
authors.lastname: Czech
authors.forename: J
authors.initials: J
authors.lastname: Raus
mesh_terms: D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D007202:Indicators and Reagents; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000032:analysis*; D012997:Solvents
chemical_list: D007202:Indicators and Reagents; D012997:Solvents; D011092:Polyethylene Glycols