Nephropathy in asymptomatic patients with active Schistosoma mansoni infection.
In this study 240 patients with active Schistosoma mansoni infection with no symptoms suggestive of glomerular disease were subjected to investigation. All were evaluated clinically and their urine was examined for proteinuria. Out of the 240 patients 48 (20%) had proteinuria as detected by the dipstick test. All these patients were found to be free of any secondary cause other than schistosomiasis which could explain their proteinuria. Out of these 48 patients, 15 agreed to be subjected to kidney biopsy. When examined by light microscopy and immunofluorescent microscopy, kidney biopsies showed positive findings in 8 cases. These were mainly focal mesangial proliferation and immunofluorescent deposits which were mainly IgM and C3. We have concluded that early kidney lesions could be detected in 20% of this particular group of patients.
Sobh
M
M
Department of Internal Medicine, Urology and Nephrology Center, Mansoura University, Egypt.
Moustafa
F
F
el-Arbagy
A
A
el-Din
M S
MS
Shamaa
S
S
Amer
G
G
D000293:Adolescent; D000328:Adult; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000473:pathology / Q000652:urine
D003176:Complement C3; D007075:Immunoglobulin M