Hemodynamic mechanisms of emerging portal hypertension caused by schistosomiasis in the hamster.
A hamster model of schistosomiasis has provided the first opportunity to sequentially examine the early phases of the development of portal hypertension in a natural model of chronic liver disease. Groups of hamsters were infected with 50 cercariae of Schistosoma mansoni and underwent hemodynamic evaluation at intervals of 5, 8, 12 and 20 wk after infection. A progressive rise in intrahepatic resistance (from 4.0 +/- 0.4 to 8.4 +/- 1.0 mm Hg min.ml-1.gm liver weight [p less than 0.01]) appeared to play a major role in the initial stages of evolving portal hypertension. A gradual decline in portal blood flow (from 2.1 +/- 0.3 to 1.3 +/- 0.1 ml.min-1.gm-1 liver weight [p less than 0.01]) was only partially compensated for by an increase in hepatic arterial flow. Accordingly, by week 20, total hepatic blood flow decreased 23%. Liver weight that increased markedly between 5 and 12 wk after infection, as a result of the acute accumulation of obstructing granulomas, stabilized between wk 12 and 20, while a gradual but progressive rise in hepatic collagen content was seen. Portal pressure increased 75% during the study period. Chronic examination of this natural model should help define the pathogenesis of the complications of portal hypertension and contribute to the basis for effective intervention in this disease process.
Morgan
J S
JS
Veterans Administration Medical Center, West Haven, Connecticut 06516.
Groszmann
R J
RJ
Rojkind
M
M
Enriquez
R
R
D000818:Animals; D003094:Collagen / Q000032:analysis; D006224:Cricetinae; D004195:Disease Models, Animal; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000503:physiopathology*; D008099:Liver / Q000032:analysis / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology; D008102:Liver Circulation; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D011168:Portal System; D011446:Prospective Studies; D012555:Schistosomiasis mansoni / Q000503:physiopathology*; D013997:Time Factors; D014655:Vascular Resistance
D003094:Collagen