[Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol].
Stimulation of lipid peroxidation, accompanied by a decrease in activity of UDP-glucuronyl- and glutathione-S-transferases, was observed in rat liver microsomes within one day after gamma-irradiation. Maximal alteration of the patterns studied was detected within 5 days. Preadministration of alpha-tocopherol, within 14 days at a dose of 200 mg/kg of body mass, prevented distinctly the impairing effect of irradiation.
Legon'kova
L F
LF
Abakumov
G Z
GZ
Bushma
M I
MI
Lukienko
P I
PI
D000818:Animals; D005609:Free Radicals; D005720:Gamma Rays; D014453:Glucuronosyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism / Q000528:radiation effects; D011837:Radiation-Protective Agents; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D005609:Free Radicals; D011837:Radiation-Protective Agents; D014810:Vitamin E; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase
Izmenenie aktivnosti UDP-gliukuronozil-, gliutation-S-transferaz i perewkisnogo okisleniia lipidov mikrosom pecheni krys pri gamma-obluchenii i zashchitnoe deĭstvie alpha-tokoferola.