title: Dosage of colloidal bismuth subcitrate in duodenal ulcer healing and clearance of Campylobacter pylori.
abstract: Sixty consecutive patients with endoscopically proven duodenal ulcers were given colloidal bismuth subcitrate tablets either as 120 mg q.d.s. or 240 mg b.d., in a randomized single-blind study. The efficacy of each regimen was determined by endoscopic examination and antral biopsy at 4 weeks; if the ulcer remained unhealed, treatment was continued and endoscopy repeated at 8 weeks. The ulcer-healing efficacy of the two regimens was identical; however, in the four times daily group only 27% remained Campylobacter pylori positive after 8 weeks of treatment compared with 58% of the twice-daily group. Similarly, only 21% of twice daily patients were free of histological gastritis compared with 42% of the four times daily patients.
authors.affiliation: Department of Gastroenterology, Meath Hospital, Dublin, Republic of Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Coghlan
authors.forename: L
authors.initials: L
authors.lastname: Hutchinson
authors.forename: D
authors.initials: D
authors.lastname: Gilligan
authors.forename: D
authors.initials: D
authors.lastname: McKenna
authors.forename: C
authors.initials: C
authors.lastname: Keane
authors.forename: E
authors.initials: E
authors.lastname: Sweeney
authors.forename: C
authors.initials: C
authors.lastname: O'Morain
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003102:Colloids; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005756:Gastritis / Q000188:drug therapy / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D016037:Single-Blind Method
chemical_list: D000897:Anti-Ulcer Agents; D003102:Colloids; D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate