title: Human polymorphonuclear leukocyte response to Pseudomonas aeruginosa grown in biofilms.
abstract: The interaction of human neutrophils with Pseudomonas aeruginosa biofilms was examined by using a chemiluminescence assay. The biofilms induced an oxidative burst response by polymorphonuclear leukocytes which was slow and only 25% of the response to planktonic bacteria. The reduced response to P. aeruginosa biofilms could play a role in the persistence of bacteria in chronic infections.
authors.affiliation: Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: E T
authors.initials: ET
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
authors.forename: K
authors.initials: K
authors.lastname: Lam
authors.forename: J W
authors.initials: JW
authors.lastname: Costerton
authors.forename: N
authors.initials: N
authors.lastname: Høiby
mesh_terms: D000464:Alginates / Q000032:analysis; D001422:Bacterial Adhesion / Q000276:immunology*; D002455:Cell Division; D015169:Colony Count, Microbial; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D010101:Oxygen Consumption; D011550:Pseudomonas aeruginosa / Q000276:immunology*
chemical_list: D000464:Alginates