Hydrodynamic properties of connective-tissue polysaccharides.
The major hydrodynamic properties of the connective-tissue polysaccharides are those that describe polysaccharide-water interaction as embodied in their osmotic-pressure and hydraulic-conductivity properties. This study shows that, for polysaccharides such as chondroitin sulphate, hyaluronate and the heparin-like polysaccharides, their hydrodynamic properties depend primarily on the presence of the uronic residue and the nature of the glycosidic linkage. Other parameters such as the degree of N-acetylation and sulphation were found not to influence these properties to any great extent. These studies particularly delineate structural-functional aspects of the connective-tissue polysaccharides in terms of their primary structure.
Comper
W D
WD
Department of Biochemistry, Monash University, Clayton, Vic., Australia.
Zamparo
O
O
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002807:Chondroitin; D002809:Chondroitin Sulfates; D003238:Connective Tissue; D004058:Diffusion; D006025:Glycosaminoglycans; D006493:Heparin; D006820:Hyaluronic Acid; D007632:Keratan Sulfate; D007700:Kinetics; D015394:Molecular Structure; D011509:Proteoglycans; D051381:Rats; D013552:Swine
D006025:Glycosaminoglycans; D011509:Proteoglycans; D006820:Hyaluronic Acid; D006493:Heparin; D002807:Chondroitin; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate