title: Involvement of the phosphoinositol (PI) system in the mechanism of hormonal imprinting.
abstract: Certain components of the phosphoinositol (PI) system are present in the unicellular Tetrahymena. Treatment of Tetrahymena with insulin did not alter the relative proportions of the examined six phospholipid components (PIP2, PIP, phosphatidylcholine, phosphatidylethanolamine, PI, PA), but the primary interaction (imprinting) with insulin accounted for an about 75% decrease in the PIP2-level and an about 20% increase in the phosphatidylethanolamine level. The experimental results strongly suggest that hormonal imprinting accounted for adjustment of the second messenger systems of Tetrahymena to an energy saving level.
authors.affiliation: Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Kovács
authors.forename: G
authors.initials: G
authors.lastname: Csaba
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D007328:Insulin / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000502:physiology*; D010743:Phospholipids / Q000378:metabolism; D015290:Second Messenger Systems / Q000187:drug effects*; D013769:Tetrahymena pyriformis / Q000187:drug effects / Q000378:metabolism
chemical_list: D007328:Insulin; D010716:Phosphatidylinositols; D010743:Phospholipids