[The effect of nizoral and tinidazole on neutrophilic phagocytic activity in patients with rubromycosis and candidiasis].
Nisoral and tinidasole effects on Trichophyton rubrum and Candida albicans ability to be destroyed by neutrophils were under study, as were the characteristics of neutrophil phagocytic activity in patients with various forms of trichophytosis and candidiasis over the course of nisoral or tinidasole therapy or combined therapy with both the drugs. Tinidasole and more so nisoral were found to enhance neutrophilic fungicidal activity towards Tr. rubrum and C. albicans. Combined therapy with nisoral and tinidasole distinctly augmented the counts of Ns-RFC and Nc-RFC and increased the values of the phagocytic index and the phagocytic number. Combined administration of the drugs was conducive to elevation of the neutrophilic ability to destroy the fundal elements.
Katsitadze
A G
AG
Khomasuridze
L A
LA
Sharashenidze
V N
VN
Mzhavanadze
N V
NV
D000293:Adolescent; D000328:Adult; D002176:Candida albicans / Q000276:immunology; D002179:Candidiasis, Cutaneous / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D014005:Tinea / Q000188:drug therapy* / Q000276:immunology; D014011:Tinidazole / Q000627:therapeutic use*; D014249:Trichophyton / Q000276:immunology
D014011:Tinidazole; D007654:Ketoconazole
Vliianie nizorala i tinidazola na fagotsitarnuiu aktivnost' neĭtrofilov bol'nykh rubromikozom i kandidozom.