Influence of dietary lipids on serum apoproteins AI and B and on intestinal synthesis of apo AI in the early weaning of piglets: comparison of saturated, unsaturated, and medium-chain triglycerides.
Early weaning of piglets induces a rapid decrease in the concentration of all plasma lipoproteins within 2 d. The decline was more progressive when 20% saturated fatty acid (lard) (SF) was added to the diet; saturated fatty acid was more effective than unsaturated fatty acid (sunflower oil) (UF). Medium-chain triglycerides had no protective effect. Intestinal synthesis of apoprotein AI was twofold higher in preweaning piglets than in adults (12.9% of total synthesis vs 5.9%, p less than 0.01) when measured in intestinal mucosa. On day 4 of weaning, synthesis was still at the preweaning level in all groups but on day 7 was maintained only by the SF diet (11.7%). We conclude that long-chain lipids, particularly saturated fatty acids, prevent a decrease in lipoproteins at weaning, mainly by maintaining intestinal apo AI synthesis at a high level.
Ansart
M C
MC
INSERM U 286, Faculté X Bichat, Paris, France.
Girard-Globa
A
A
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D001055:Apolipoproteins B / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D005224:Fats, Unsaturated / Q000008:administration & dosage / Q000378:metabolism*; D005227:Fatty Acids / Q000008:administration & dosage / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D009924:Organ Culture Techniques; D013552:Swine; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D014886:Weaning
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002788:Cholesterol Esters; D004041:Dietary Fats; D005224:Fats, Unsaturated; D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides