title: Controlled trial of twice a day versus once a day cimetidine therapy for duodenal ulcer.
abstract: A randomized controlled trial was carried out to compare the efficacy of conventional 400 mg twice daily dose of cimetidine with single bedtime 800 mg dose, in 40 patients with endoscopically proven duodenal ulcer. At repeat endoscopy after four weeks of therapy, complete ulcer healing was achieved in 78% of patients on twice daily dosage and 79% of patients on single daily dosage. A more convenient single nocturnal dosage of cimetidine is as effective in the treatment of duodenal ulcer as a twice daily dosage in the Indian population.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: R
authors.initials: R
authors.lastname: Kochhar
authors.forename: B B
authors.initials: BB
authors.lastname: Gupta
authors.forename: M K
authors.initials: MK
authors.lastname: Goenka
authors.forename: S K
authors.initials: SK
authors.lastname: Mehta
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D011307:Drug Prescriptions; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D002927:Cimetidine