Determination of imipenem in human plasma, urine and tissue by high-performance liquid chromatography.
A simple and reliable HPLC method is described for the new beta-lactam antibiotic imipenem; suitable extraction procedures for the drug in human plasma, urine and prostatic tissue are described. The figures of merit for the assays are reported and examples given of their application.
Carlucci
G
G
Dipartimento di Chimica, Università degli Studi dell'Aquila, Italy.
Biordi
L
L
Vicentini
C
C
Bologna
M
M
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015378:Imipenem / Q000032:analysis* / Q000097:blood / Q000652:urine; D008297:Male; D011467:Prostate / Q000737:chemistry
D015378:Imipenem