In vitro activity of cefpodoxime proxetil (U-76,252; CS-807) against Neisseria gonorrhoeae.
Cefpodoxime proxetil is an oral cephalosporin antibiotic. The in vitro activities of cefpodoxime (the active metabolite of cefpodoxime proxetil), ceftriaxone, and cefuroxime against both antibiotic-susceptible and antibiotic-resistant clinical isolates of Neisseria gonorrhoeae were determined. Cefpodoxime inhibited all penicillin-susceptible strains and penicillinase-producing strains at less than or equal to 0.015 microgram/ml; chromosomally resistant strains were inhibited by cefpodoxime at less than or equal to 0.125 microgram/ml.
Schaadt
R D
RD
Infectious Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
Yagi
B H
BH
Zurenko
G E
GE
D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D002443:Ceftriaxone / Q000493:pharmacokinetics / Q000494:pharmacology; D002444:Cefuroxime / Q000493:pharmacokinetics / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006207:Half-Life; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D000097627:Cefpodoxime Proxetil
D015296:Ceftizoxime; D002443:Ceftriaxone; D002444:Cefuroxime; D010405:Penicillinase; D000097627:Cefpodoxime Proxetil