title: In vivo and in vitro degradation of monofilament absorbable sutures, PDS and Maxon.
abstract: Two new absorbable monofilament suture materials polydioxanone and Maxon are being employed increasingly in abdominal surgery because of increased strength retention and decreased tissue reactivity compared with previously available materials. As part of our investigation of the behaviour of suture materials, 3-0 sutures of polydioxanone and Maxon were enclosed in nylon pouches, a technique developed for in vivo experiments to prevent cellular interaction with implanted devices. The pouched sutures were gas sterilized, then implanted in either the extrafascial space or peritoneal cavity for periods of 1-5 wk. Sterilized sutures were also incubated in Ringer's lactate at 37 degrees C. Tensile strength of the exposed sutures was measured. For a given suture material and duration of incubation, there was no significant difference in tensile strength degradation among the three test environments. Although the strength of unexposed Maxon is greater than that of polydioxanone, the residual strength of Maxon decreases more rapidly in use, so that, after 2 wk, the strength of polydioxanone is greater. Scanning electron microscope examination of the suture surfaces reveals that polydioxanone develops surface crazing with time, whereas the surface morphology of Maxon remains relatively unaltered.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, University of Louisville, KY 40292.
authors.forename: S A
authors.initials: SA
authors.lastname: Metz
authors.forename: N
authors.initials: N
authors.lastname: Chegini
authors.forename: B J
authors.initials: BJ
authors.lastname: Masterson
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D005260:Female; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016687:Polydioxanone; D011091:Polyesters; D011108:Polymers; D011817:Rabbits; D013537:Sutures; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D016687:Polydioxanone; C046409:polyglyconate