title: Cyclodextrin chiral stationary phases for liquid chromatographic separations of drug stereoisomers.
abstract: Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided.
authors.affiliation: Department of Chemistry, University of Missouri-Rolla 65401.
authors.forename: A
authors.initials: A
authors.lastname: Berthod
authors.forename: H L
authors.initials: HL
authors.lastname: Jin
authors.forename: T E
authors.initials: TE
authors.lastname: Beesley
authors.forename: J D
authors.initials: JD
authors.lastname: Duncan
authors.forename: D W
authors.initials: DW
authors.lastname: Armstrong
mesh_terms: D002853:Chromatography, Liquid; D003505:Cyclodextrins; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins