title: Fibrinogen, factor VII clotting activity and coronary artery disease severity.
abstract: To asses the relationship between fibrinogen, factor VII coagulant (VIIc) activity and extent of coronary artery disease, we studied 43 white males shown to have greater than 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and were classified as having 1, 2 or 3 vessel disease while 7 had 2 or 3 vessel disease, but no prior infarction. Groups were similar with regard to age, body mass index and blood pressure. In those with documented prior infarction, there was a significant relationship between the extent of atheroma and coagulation variables factor VIIc and fibrinogen. However, given a similar degree of atheroma, patients with prior infarction had significantly higher levels of factor VIIc activity compared with patients without such a history. These results corroborate those from prospective studies confirming a significant role for the coagulation system in the clinical manifestation of coronary artery disease.
authors.affiliation: Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Broadhurst
authors.forename: C
authors.initials: C
authors.lastname: Kelleher
authors.forename: L
authors.initials: L
authors.lastname: Hughes
authors.forename: J D
authors.initials: JD
authors.lastname: Imeson
authors.forename: E B
authors.initials: EB
authors.lastname: Raftery
mesh_terms: D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D005167:Factor VII / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D005167:Factor VII; D005340:Fibrinogen; D002784:Cholesterol