title: Biochemical characterization of amyloid derived from the variable region of the kappa light chain subgroup III.
abstract: We report the clinical data and results of biochemical studies of amyloid in a postpartum patient. The amyloidosis was not associated with myeloma, and immunopathologic examination of the amyloid deposits gave inconclusive results. Biochemical analysis of the deposits proved that the amyloid protein JUN was derived from the variable region of the kappa light chain subgroup III and is homologous to a rarely expressed protein POM, which was previously shown to have rheumatoid factor activity. The significance of this association and the diagnostic problems associated with certain cases of amyloid derived from immunoglobulin light chain (type AL) are discussed.
authors.affiliation: Department of Pathology, New York University Medical Center, NY 10016.
authors.forename: M M
authors.initials: MM
authors.lastname: Picken
authors.forename: G R
authors.initials: GR
authors.lastname: Gallo
authors.forename: W
authors.initials: W
authors.lastname: Pruzanski
authors.forename: B
authors.initials: B
authors.lastname: Frangione
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000682:Amyloid / Q000235:genetics / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D007135:Immunoglobulin Variable Region / Q000378:metabolism*; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D008970:Molecular Weight; D049590:Postpartum Period
chemical_list: D000682:Amyloid; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains