title: X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster.
abstract: Mutants of Drosophila melanogaster that are sensitive to chemical mutagens were analyzed for sensitivity to X-rays and for the capacity to repair single-strand DNA breaks induced by X-rays. Analysis of X-ray sensitivity demonstrated that 74% of the mutants assayed display some X-ray sensitivity, with 75% of the sensitive lines being extremely sensitive. Repair of single-strand breaks was assayed after both high and low doses of irradiation in order to permit detection of repair over a wide range of damage. The results of this investigation fail to show a correlation between X-ray sensitivity and this particular repair process. Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection.
authors.affiliation: Department of Genetics, University of California, Davis 95616.
authors.forename: D R
authors.initials: DR
authors.lastname: Oliveri
authors.forename: P V
authors.initials: PV
authors.lastname: Harris
authors.forename: J B
authors.initials: JB
authors.lastname: Boyd
mesh_terms: D000818:Animals; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000528:radiation effects; D007700:Kinetics; D009153:Mutagens; D009154:Mutation; D011836:Radiation Tolerance; D014965:X-Rays
chemical_list: D004277:DNA, Single-Stranded; D009153:Mutagens