Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties.
The requirements for activity in a tumour-photosensitizing drug are outlined. A series of metallo tetrasulphonatophthalocyanines are shown to be inactive in an in vivo assay of tumour photosensitization; however, some less water-soluble compounds (hydroxylated derivatives of octaethylchlorin and octaethylbacteriochlorin) are shown to possess promising activity.
Bonnett
R
R
Department of Chemistry, Queen Mary and Westfield College, London U.K.
Nizhnik
A N
AN
White
S G
SG
Berenbaum
M C
MC
D000818:Animals; D002460:Cell Line; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C006969:chlorin