[The effect of PGI2 analogue on the warm ischemic changes in canine lung].
The purpose of this study is to evaluate the effect of PGI2 analogue on the warm ischemic injury in the reimplantation model of the lung. Twenty-five mongrel dogs were subjected to this experiment in which the left thoracotomy and complete left hilar stripping were performed. The dogs were divided into 4 groups. The control group (8 dogs) did not have any medical treatment. I2 1 microgram group (7 dogs) received PGI2 analogue in the amount of 1 microgram/kg/min for 30 min during hilar dissection. I2 50 ng group (5 dogs) received PGI2 analogue in the amount of 50 ng/kg/min for 30 minutes. Heparin group (5 dogs) received 100 U/kg of heparin after hilar stripping. Then left, PA, PV, and Bronchus were clamped for 1 hour to make the left lung a warm ischemic state. To evaluate the function of the left lung subjected for a warm ischemia, right pulmonary artery was occluded for 10 minutes and PaO2, PaCO2, Qs/Qt, pulmonary artery pressure, pulmonary vascular resistance, thromboxane B2, and 6-keto-PGF1 alpha were measured. Two hours after reperfusion, pulmonary microangiography and histological investigation were performed. As a result of warm ischemia, PaO2 was 158 mmHg with 70% FiO2 1 hour after reperfusion in control group, whereas it was maintained at as high as 299 mmHg in I2 1 microgram group. PaCO2, Qs/Qt, pulmonary artery pressure, as well as the pulmonary vascular resistance were almost normal throughout the experiment in I2 1 microgram group, but they gradually elevated in control group during the experiments. In the other two groups these parameter are not so satisfactory as in I2 1 microgram group.(ABSTRACT TRUNCATED AT 250 WORDS)
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Department of Surgery, Kobe University School of Medicine, Japan.
Yamashita
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D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D008168:Lung / Q000098:blood supply* / Q000648:ultrastructure; D016040:Lung Transplantation; D011652:Pulmonary Circulation; D013696:Temperature
D011464:Epoprostenol; C035847:ataprost