Modulating the microbial colonization of the gastrointestinal tract by oral administration of defined Escherichia coli strains. III. Lipopolysaccharide-specific IgA in the intestine after oral administration of Escherichia coli.
The assumption that local immunologic mechanisms are responsible for findings on the specific microbial colonization of the gastrointestinal tract of mice, is confirmed by results described in the present communication. Quantitative examination of intestinal lavage fluids after oral administration of germs by ELISA showed that (i) there is a critical dose above which a significant increase of IgA synthesis is observable; (ii) low antibody levels could be detected already in the untreated control group. It may be assumed that--regardless of the biological characteristics of the administered strain, namely, substrate and receptor competition--the stimulability of local immunity provides against permanent monocolonization with displacement of the autochthonous Enterobacteriaceae in adult and immunocompetent hosts.
Schröder
R
R
Institute of Medical Microbiology, Karl Marx University, Leipzig, FRG.
Blatz
R
R
Linde
K
K
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D004064:Digestive System / Q000276:immunology / Q000382:microbiology*; D004306:Dose-Response Relationship, Immunologic; D004926:Escherichia coli / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D008070:Lipopolysaccharides