Progressive bone loss during long-term home total parenteral nutrition.
Metabolic bone disease occurs in patients receiving prolonged home total parenteral nutrition (HTPN). We studied bone-mass status in 10 patients (seven males, three females, age 19-66 years) who had been receiving HTPN for 0 to 67 months (mean 24 months), mostly for short-bowel syndrome. Four patients had spinal osteoporosis on radiograms. The density of various bone components at the wrist was measured noninvasively using a novel technique based on Compton scattering effect. The density of the cancellous and cortical bone was decreased in nine and six patients, respectively. During a follow-up period of up to 19 months, a further significant decrease in the density of both bone components was found. We conclude that prolonged HTPN is associated with an ongoing bone diminution, affecting mainly the cancellous bone.
Foldes
J
J
Jerusalem Osteoporosis Center, Israel.
Rimon
B
B
Muggia-Sullam
M
M
Gimmon
Z
Z
Leichter
I
I
Steinberg
R
R
Menczel
J
J
Freund
H R
HR
D000328:Adult; D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006701:Home Nursing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012778:Short Bowel Syndrome / Q000150:complications / Q000628:therapy