[Behavior of various enzyme activities during high blood lactate and pyruvate levels in albino rats reared in a normobaric hypoxic atmosphere for 1 or 2 generations].
Albino rats Wistar family raised in normobaric hypoxic environment (10% O2 in N2) since one or two generations showed an increase in arterial blood creatine-kinase, glutamate-dehydrogenase, lactic-dehydrogenase, lactate and pyruvate when compared with normoxic controls. Moreover the values found in hypoxic rats of second generation were intermediate between those found in hypoxic rats of first generation and normoxic controls. These differences are probably due to an improved efficiency of the processes of cellular adaptation to the hypoxic environment when named species remain in hypoxic environment for more than one generation.
Licciardi
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A
Istituto di Fisiologia Umana, Università di Palermo.
Morici
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G
D000136:Acid-Base Equilibrium; D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D003402:Creatine Kinase / Q000097:blood*; D005969:Glutamate Dehydrogenase / Q000097:blood*; D000860:Hypoxia / Q000097:blood / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D003402:Creatine Kinase
Andamento di alcune attivita' enzimatiche, della lattatemia e piruvatemia in ratti albini allevati in ambiente ipossico normobarico da una o due generazioni.