title: Sodium D-lactate infusion of panic disorder patients.
abstract: Nineteen patients with panic disorder received sodium D,L-lactate (racemic) and pure sodium D-lactate infusions in a pilot study. Sodium D-lactate, which is less metabolically active than L-lactate, produced panic attacks in half the patients. D-Lactate also produced hypocapnia and alkalosis, indicating hyperventilation. These findings suggest that metabolism of lactate is not necessary for the induction of panic in susceptible patients. D-Lactate appears similar to other agents that cause panic in its capacity to stimulate respiration in the preliminary study.
authors.affiliation: Biological Studies Unit, New York State Psychiatric Institute, NY.
authors.forename: J M
authors.initials: JM
authors.lastname: Gorman
authors.forename: R R
authors.initials: RR
authors.lastname: Goetz
authors.forename: D
authors.initials: D
authors.lastname: Dillon
authors.forename: M R
authors.initials: MR
authors.lastname: Liebowitz
authors.forename: A J
authors.initials: AJ
authors.lastname: Fyer
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000503:physiopathology; D001639:Bicarbonates / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D005239:Fear; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006985:Hyperventilation / Q000139:chemically induced / Q000503:physiopathology; D007262:Infusions, Intravenous; D007773:Lactates / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D019344:Lactic Acid; D008297:Male; D010200:Panic; D010698:Phobic Disorders / Q000139:chemically induced / Q000503:physiopathology*; D010710:Phosphates / Q000097:blood; D010865:Pilot Projects; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013237:Stereoisomerism
chemical_list: D001639:Bicarbonates; D007773:Lactates; D010710:Phosphates; D011773:Pyruvates; D002245:Carbon Dioxide; D019344:Lactic Acid; D019289:Pyruvic Acid; D002118:Calcium