Comparison of T suppressor factors from tumour-bearing mice and mice immunized with a monoclonal anti-idiotypic antibody.
Certain dosage schedules of a monoclonal anti-idiotypic antibody (related to a murine bladder carcinoma) were found to induce suppressor factor production by syngeneic mice. This suppressor factor resembled the factor from tumour-bearing mice with respect to idiotype specificity, possession of molecular markers (reactive with anti-IJ and B16G antibodies) and production by Lyt2+IJ+ T cells in spleen cell cultures. The two factors differed with respect to Igh restriction in an in vitro assay (leucocyte adherence inhibition) and ability to suppress the induction of delayed-type hypersensitivity to tumour antigen.
Greer
J M
JM
Department of Microbiology, University of Queensland, Brisbane, Australia.
Halliday
W J
WJ
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005354:Fibrosarcoma / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000276:immunology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D007143:Immunoglobulin Heavy Chains; D013491:Suppressor Factors, Immunologic