title: Observations on the intestinal colonization by Pseudomonas aeruginosa in newborn infants.
abstract: We studied the intestinal flora of 23 newborns, whose meconium had yielded a pure culture of Pseudomonas aeruginosa on blood agar medium. Twelve infants had a single serotype of P. aeruginosa in their meconium, 10 had a second serotype and the last infant was carrying three distinct ones. The maximum levels of P. aeruginosa observed during the first week of life were variable among the infants: 1 x 10(3) to 1 x 10(10) CFU/g of stools. The levels diminished progressively afterwards, and after 1 year of age only 1 of the 13 infants examined remained a carrier of P. aeruginosa. In 11 infants a second or a third serotype occurred during the course of the study. The serotypes that appeared secondarily always disappeared before the initial ones. Antibiotics: ampicillin + gentamicin or cefotaxime + netilmicin and colistin which were given to 8 infants had no clear effect on P. aeruginosa levels. Four infants had delayed colonization by Escherichia coli of greater than or equal to 10 days. All 4 had high levels of P. aeruginosa: 1 x 10(7) to 1 x 10(10) CFU/g stool, and antibiotic therapy, rendering it impossible to assess which was the cause of this delay. This colonization by P. aeruginosa did not lead to any clinical trouble.
authors.affiliation: Laboratoire de Biologie, CHR Orléans, France.
authors.forename: E
authors.initials: E
authors.lastname: Borderon
authors.forename: J C
authors.initials: JC
authors.lastname: Thieffry
authors.forename: O
authors.initials: O
authors.lastname: Jamet
authors.forename: D
authors.initials: D
authors.lastname: Poisson
authors.forename: C
authors.initials: C
authors.lastname: Boisseau
authors.forename: I A
authors.initials: IA
authors.lastname: Farid
mesh_terms: D002439:Cefotaxime / Q000627:therapeutic use; D003091:Colistin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D007410:Intestinal Diseases / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008470:Meconium / Q000382:microbiology; D009428:Netilmicin / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012703:Serotyping; D013982:Ticarcillin / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D005839:Gentamicins; D009428:Netilmicin; D013982:Ticarcillin; D002439:Cefotaxime; D003091:Colistin