[Transplant glomerulopathy. Anatomohistopathologic and ultrastructural aspects].
14 cases of transplant glomerulopathy have been observed in 254 specimen taken from 152 renal allografted patients. Lesions have been studied at light, immunofluorescence and ultrastructural level. Following morphological parameters have been evaluated by semiquantitative method: focal mesangial sclerosis, mesangial matrix, mesangial cellularity, glomerular basement membrane thickening, double contours and crescents. Intermediate and advanced stages prevailed with the evidence of capillary aneurysms in 2 out 14 cases. Electron microscopy showed thickening of the glomerular basement membrane with finely lamellar and electron lucent thickening of the lamina rara interna. Transplant glomerulopathy lesions need differential diagnosis with thrombotic microangiopathy and can be considered equivalent of chronic vascular rejection.
Sacchi
G
G
II Servizio di anatomia ed istologia patologica degli Spedali Civili di Brescia.
Fiorentino
M
M
Rodolfi
A
A
Benetti
A
A
Cannella
G
G
D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged
La glomerulopatia da trapianto. Aspetti anatomoistopatologici ed ultrastrutturali.