[Protective effect of ascorbic acid in cells of people exposed to cobalt chloride].
The workers contacting with cobalt chloride for 10 years and more have been receiving 50 mg ascorbic acid for 30 days. DNA repair was analysed after this procedure in lymphocytes cultivated in vitro according to following criteria: reactivation and induced mutagenesis of vaccinia virus as well as formation of DNA breaks and their resynthesis upon treatment with cobalt chloride and 4-nitro-quinoline-1-oxide.
L'vova
G N
GN
Chopikashvili
L V
LV
Vasil'eva
I M
IM
Zasukhina
G D
GD
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D001205:Ascorbic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D003035:Cobalt / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000382:microbiology; D009153:Mutagens; D016273:Occupational Exposure; D014616:Vaccinia virus / Q000235:genetics
D009153:Mutagens; D003035:Cobalt; D015112:4-Nitroquinoline-1-oxide; C018021:cobaltous chloride; D001205:Ascorbic Acid
Zashchitnoe deĭstvie askorbinovoĭ kisloty v kletkakh liudeĭ, kontaktiruiushchikh s khloridom kobal'ta.