[Effect of nitroglycerin preparations on indicators of central hemodynamics in patients with pulmonary tuberculosis complicated by chronic cor pulmonale].
The effect of nitroglycerin drugs on central hemodynamic indices in 198 patients with pulmonary tuberculosis and chronic nonspecific pulmonary diseases was investigated. These studies revealed that in pulmonary tuberculosis, nitroglycerin caused blood pooling in peripheral vessels, a decrease in the central hemodynamic indices and an increase in the right heart. A single dose of nitrogen, 2.6 mg, given to a patient with hypokinetic circulation leads to the improvement of the central hemodynamic indices (circulating blood volume (CBV), stroke and cardiac indices, lung CBV) due to less peripheral angiospasm, peripheral circulation normalization and better blood supply to the right heart. A fortnight nitrogen regimen in a dosage of 2.6 mg thrice a day makes it possible to normalize the central hemodynamic indices and decrease pressure in the pulmonary artery in patients with pulmonary tuberculosis complicated by a chronic pulmonary heart with a hypokinetic circulation.
Mar'iandyshev
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AO
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D011660:Pulmonary Heart Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000503:physiopathology*
D005996:Nitroglycerin
Vliianie preparatov nitroglitserina na pokazateli tsentral'noĭ gemodinamiki u bol'nykh tuberkulezom legkikh, oslozhnennym khronicheskim legochnym serdtsem.