Neuropeptide Y (NPY)-containing nerves in mammalian ureter.
The distribution of neuropeptide Y in the ureter of the rat, rabbit, and man has been determined by radioimmunoassay and chromatographic analysis of the tissue extract. The localization of neuropeptide Y-immunoreactivity has been identified by immunocytochemistry. A regional distribution of neuropeptide Y was found; highest concentrations being present in the ureterovesical junction. Throughout the ureter, neuropeptide Y-immunoreactive nerve fibers were identified to surround the blood vessels and a few plexuses of neuropeptide Y-containing nerves were present within the muscle layers. Neuropeptide Y was not present within ganglion cells. Treatment of rats with 6-hydroxydopamine resulted in a significant reduction of neuropeptide Y concentrations in the upper, middle, and lower thirds of the ureter. This depletion in extractable neuropeptide Y was associated with morphologic changes typical of axonal degeneration of the neuropeptide Y-containing nerve fibers.
Allen
J M
JM
Department of Medicine, Royal Postgraduate Medical School, London, England.
Rodrigo
J
J
Kerle
D J
DJ
Darcy
K
K
Williams
G
G
Polak
J M
JM
Bloom
S R
SR
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D007124:Immunoenzyme Techniques; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism; D009478:Neuropeptide Y / Q000032:analysis*; D016627:Oxidopamine; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000033:anatomy & histology / Q000378:metabolism; D014513:Ureter / Q000294:innervation* / Q000378:metabolism
D006892:Hydroxydopamines; D009478:Neuropeptide Y; D016627:Oxidopamine