Biological studies on 1,2-benzisothiazole derivatives. III. Evaluation of antibacterial, antifungal and DNA-damaging activities of 1,2-benzisothiazolin-3-ones.
The in vitro evaluation of the antibacterial, antifungal and DNA-damaging properties of some 1,2-benzisothiazolin-3-one derivatives is described. Antibacterial activity against Gram+ microorganisms (Bacillus subtilis and Staphylococcus aureus) was demonstrated in some N-alkoxybenzyl, N-aryl and N-alkoxyphenyl derivatives. Antifungal activity turned out to be strongly affected by the substituents considered. Some derivatives exhibited selective activity against the fungi used. Poor antimicrobial activity was observed in the N-chlorocarbonylphenyl and N-carboxyamidophenyl derivatives. None of the compounds tested turned out to have any genotoxic properties.
Massimo
G
G
Istituto di Tecnica Farmaceutica, Università di Parma, Italy.
Zani
F
F
Coghi
E
E
Bellotti
A
A
Mazza
P
P
D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004249:DNA Damage; D005658:Fungi / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009153:Mutagens; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
D009153:Mutagens; D013844:Thiazoles