Transplantation of islets of Langerhans isolated by Trowell's T8 medium in outbred rats: effect of cyclosporine.
This study was carried out to investigate the efficacy of cyclosporine to prolong islets isolated by collagenase in Trowell's T8 medium and Ficoll gradient separation. Our results demonstrate that a short course of cyclosporine is effective in minimizing rejection of transplanted islets in outbred rats.
al-Abdullah
I H
IH
Department of Organ Transplantation, Faculty of Medicine, Kuwait University, Safat.
Kumar
M S
MS
al-Adnani
M S
MS
Abouna
G M
GM
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient; D003470:Culture Media; D003524:Cyclosporins / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000601:surgery*; D005362:Ficoll; D006084:Graft Rejection; D006085:Graft Survival; D007515:Islets of Langerhans / Q000166:cytology*; D016381:Islets of Langerhans Transplantation / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D003470:Culture Media; D003524:Cyclosporins; D005362:Ficoll