[Genetic mechanisms for the regulation of natural killer cell activity].
The problems on genetic mechanisms of regulation of natural killer cells, participation of major histocompatibility complex in these processes are considered. The examples of mutations and hereditary diseases accompanied by disfunction of the natural killer activity are presented. It is supposed that genetic predisposition of natural killer activity depression can promote an increase in the risk of malignant and autoimmune diseases.
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D000818:Animals; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D009154:Mutation
Geneticheskie mekhanizmy reguliatsii deiatsel'nosti estestvennykh killernykh kletok.