title: Efficacy of various single-dose regimens of ceftriaxone in uncomplicated acute gonococcal urethritis in adult males.
abstract: The therapeutic efficacy of single intramuscular doses of ceftriaxone (Rocephin; Roche) (62.5, 125 and 250 mg), administered without probenecid, was evaluated in 167 adult males with uncomplicated acute gonococcal urethritis. Cure rates of 100% were achieved at 62.5 mg and 250 mg. In the 125 mg dose group, Neisseria gonorrhoeae was isolated from 1 patient at follow-up after therapy. Reinfection was suspected, since this patient returned on day 10 and admitted to sexual contact 2 days previously. Side-effects were minimal, and patient acceptance was better for ceftriaxone dissolved in lignocaine than in sterile water. Chlamydia trachomatis was detected at follow-up in 14.4% patients, confirming that ceftriaxone has no significant effect on chlamydial infection and additional treatment is necessary for patients with coexistent infection.
authors.affiliation: Department of Medical Microbiology, University of Natal, Durban.
authors.forename: A A
authors.initials: AA
authors.lastname: Hoosen
authors.forename: N
authors.initials: N
authors.lastname: O'Farrell
authors.forename: K D
authors.initials: KD
authors.lastname: Coetzee
authors.forename: J
authors.initials: J
authors.lastname: van den Ende
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage*; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D005069:Evaluation Studies as Topic; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D014509:Ureaplasma / Q000302:isolation & purification; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D002443:Ceftriaxone