Charge densities of atoms of conjugated styryl ketones having activity against L1210 leukemia cells.
Electron density calculations were undertaken on several atoms in a series of 3-substituted-4-phenyl-3-buten-2-ones in order to gain insight into the molecular features which affect charge densities. The results indicate that substituents at position 3 alter the electron densities of the olefinic group but have little effect on the acetyl function. The compounds were tested against L1210 cells in vitro, and the results suggest that electronic--but not steric--factors are important in affecting cytotoxicity. The most active compound was 3-phenylmethylene-2,4-pentanedione (1c) with an ED50 value of 1.06 x 10(-8) M.
Dimmock
J R
JR
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Erciyas
E
E
Sidhu
K K
KK
Luo
X
X
Mezey
P G
PG
Allen
T M
TM
Murray
L
L
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology*; D013343:Styrenes / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D007659:Ketones; D013343:Styrenes