[Detection of B-cell marker of rheumatism using monoclonal antibodies D8/17 in families of patients with rheumatism (report 1)].
Results of clinico-genealogical and immunogenetic examination of 220 persons including 150 patients suffering from rheumatism and members of their families have been presented. The object of the examination was a B-cell marker carriership to be determined by means of monoclonic antibodies D8/17 with the use of the microlymphocytotoxic method. The marker carriership was detected in 96 per cent of probands-patients with rheumatism and in 40.3 per cent of their relatives and in 6.7 per cent of healthy individuals of the control group. A possible contribution of the B-cell marker to rheumatism liability was suggested. A further study of the role of the given marker in rheumatism has been found advisable.
Shostak
N A
NA
Anokhin
V N
VN
Kazakova
T V
TV
Morozova
E I
EI
Zolkina
I V
IV
Voĭlokova
R Ia
RIa
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012216:Rheumatic Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology
D000911:Antibodies, Monoclonal; D005819:Genetic Markers
Vyiavlenie B-kletochnogo markera revmatizma s pomoshch'iu monoklonal'nykh antitel D8/17 v sem'iakh bol'nykh revmatizmom (soobshchenie 1).