title: Ethanol decreases the level of sulfhydryl compounds in red blood cells and changes their hematological pattern in rats.
abstract: The level of sulfhydryl compounds in red blood cells (RBCs) and plasma and some haematological parameters were investigated in rats treated with ethanol for 4 weeks (daily dose of 6g/kg, 30% w/v, p.o.). After ethanol ingestion, the significant decrease of non-protein - SH groups were observed in RBCs and plasma. In treated rats, the mean corpuscular haemoglobin concentration (MCHC) was decreased and the mean corpuscular volume (MCV) was increased. There is a positive correlation between these two parameters and decreased content of sulfohydryl groups in RBCs.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Medical Academy, Białystok, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Chwiecko
authors.forename: D
authors.initials: D
authors.lastname: Pawlowska
authors.forename: A
authors.initials: A
authors.lastname: Holownia
authors.forename: R
authors.initials: R
authors.lastname: Farbiszewski
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D006403:Hematologic Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D013438:Sulfhydryl Compounds; D000431:Ethanol