Absence of zinc cytotoxicity. Effect of short-term zinc oral administration on rat gastric mucosa.
Zinc ions have been reported to stabilize cellular membranes, protecting the gastric mucosa against a wide variety of ulcerative agents. The treatment with zinc sulfate intragastrically administered as one dose (20 mg/kg body weight) daily for 30 consecutive days did not modify the normal aspect of rat gastric mucosa as observed by electron scanning microscopy. Furthermore, the X-ray microanalysis of the lysosome content performed on different gastric mucosa cells did not show the zinc element. These results suggest that zinc ion is a relatively nontoxic element for the rat gastric mucosa.
Rodrigues
L E
LE
Departamento de Biofunção, Universidade Federal da Bahia, Salvador, Brasil.
Mathias
C M
CM
Siry
P
P
Galle
P
P
D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc