[Effect of monocrotaline on human kidney cells].
The effect of monocrotaline on human kidney cells has been studied by means of monolayer cell culture, cytochemistry and 3H-thymidine incorporation. The result shows that this drug can inhibit cell DNA synthesis, featuring an irreversible damaging action to DNA templet. Also, when the process of glycolysis and saccharide utilization in the cells is inhibited, the amount of lactic acid produced decreases and the pH value becomes higher.
Yin
L
L
Shandong Academy of Medical Sciences, Jinan.
Zhang
F
F
D004247:DNA / Q000096:biosynthesis; D004249:DNA Damage; D005333:Fetus; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D016686:Monocrotaline; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology*
D007773:Lactates; D011763:Pyrrolizidine Alkaloids; D019344:Lactic Acid; D016686:Monocrotaline; D004247:DNA