Interleukin-2, anti-interleukin-2 receptor antibody, and activation of macrophages.
Macrophages treated with IFN-gamma and IL-2 before exposure to parasites develop the ability to resist infection with amastigotes of Leishmania major. In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors or antigens. Thus, antibodies to the IL-2 receptor act as agonists of IL-2 in the induction of a biologic activity in macrophages, and macrophages, a nonproliferating cell type, respond to signals transmitted through the beta chain of the IL-2 receptor.
Belosevic
M
M
Department of Cellular Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
Nacy
C A
CA
D000818:Animals; D000911:Antibodies, Monoclonal; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000494:pharmacology; D007376:Interleukin-2 / Q000502:physiology*; D007895:Leishmania tropica; D007896:Leishmaniasis / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D011971:Receptors, Immunologic / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D015398:Signal Transduction
D000911:Antibodies, Monoclonal; D007376:Interleukin-2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma