title: [Skin spots, skin nodules, gangrene of the toes].
abstract: A 42-year-old man with multiple cutaneous neurofibromacules, café-au-lait and gangrene of toes was diagnosed having neurofibromatosis in 1976. An aortography performed because of severe hypertension had shown a coarctation and bilateral renal artery stenosis in 1982. Conservative antihypertensive therapy with an ACE-inhibitor, a vasodilatating agent and a diuretic resulted in gradual normalisation of blood pressure values. A recent follow-up revealed minimal progression of neurofibromatosis and hypertensive lesions documenting a benign course for over 13 years.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: T
authors.initials: T
authors.lastname: Mengden
authors.forename: B
authors.initials: B
authors.lastname: Marincek
authors.forename: A
authors.initials: A
authors.lastname: Zynamon
authors.forename: W
authors.initials: W
authors.lastname: Vetter
mesh_terms: D000328:Adult; D001017:Aortic Coarctation / Q000150:complications / Q000000981:diagnostic imaging; D001027:Aortography; D005734:Gangrene; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D012078:Renal Artery Obstruction / Q000150:complications / Q000000981:diagnostic imaging; D014034:Toes / Q000473:pathology
vernacular_title: Hautflecken, Hautknoten, Zehengangrän.