Ethanol decreases the level of sulfhydryl compounds in red blood cells and changes their hematological pattern in rats.
The level of sulfhydryl compounds in red blood cells (RBCs) and plasma and some haematological parameters were investigated in rats treated with ethanol for 4 weeks (daily dose of 6g/kg, 30% w/v, p.o.). After ethanol ingestion, the significant decrease of non-protein - SH groups were observed in RBCs and plasma. In treated rats, the mean corpuscular haemoglobin concentration (MCHC) was decreased and the mean corpuscular volume (MCV) was increased. There is a positive correlation between these two parameters and decreased content of sulfohydryl groups in RBCs.
Chwiecko
M
M
Department of Inorganic and Analytical Chemistry, Medical Academy, Białystok, Poland.
Pawlowska
D
D
Holownia
A
A
Farbiszewski
R
R
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D006403:Hematologic Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000097:blood*
D013438:Sulfhydryl Compounds; D000431:Ethanol