Application of solid-phase extraction to the isolation and determination of paracetamol and its metabolites.
A series of clean-up columns for solid-phase extraction (SPE) were packed with various C18 phases of different physico-chemical surface properties. These SPE columns were used for the isolation and determination of paracetamol and its metabolites from biological samples. The packing with a monomeric structure of chemically bonded phase showed the best recovery of tested substances in urine.
el Mouelhi
M
M
Institute of Toxicology, University of Tübingen, FRG.
Buszewski
B
B
D000082:Acetaminophen / Q000032:analysis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D006801:Humans; D013056:Spectrophotometry, Ultraviolet
D000082:Acetaminophen