[Effect of indapamide preparations on myocardial contractility and hemodynamics in patients with hypertension].
The hemodynamics and myocardial contractility were studied in 64 patients with Stages I-II hypertensive disease during 12-week monotherapy with indapamide agents (Fludex, Arifon, Lorvas). Their antihypertensive effect occurred 7-8 days later, with its peak at week 4, and was recorded in 64% patients, by normalizing the above parameters in 48% who had mainly lower or normal ejection and higher peripheral resistance. Improvement of hemodynamic and myocardial contractile parameters was parallel to a reduction in blood pressure.
Sadykov
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D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007190:Indapamide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D000959:Antihypertensive Agents; D007190:Indapamide
Vliianie preparatov indapamida na sokratitel'nuiu funktsiiu miokarda i gemodinamiku bol'nykh gipertonicheskoĭ bolezn'iu.