Equivalency of human menopausal gonadotropin and follicle-stimulating hormone stimulation after gonadotropin-releasing hormone agonist suppression.
This study compares the use of human menopausal gonadotropin (hMG) versus follicle-stimulating hormone (FSH), after gonadotropin-releasing hormone agonist (GnRH-a) suppression for in vitro fertilization. Thirty-seven patients were randomized to ovarian stimulation with either hMG or pure FSH. The GnRH-a leuprolide acetate was administered to all patients beginning in the midluteal phase of the prior cycle and continuing until the day of human chorionic gonadotropin (hCG) administration. There were no significant differences between hMG and FSH cycles with regard to the day of hCG administration, mean peak estradiol levels, number of ampules of medication used, and number of oocytes aspirated, embryos transferred, or pregnancies. We conclude that there is no significant difference between hMG and FSH stimulation when used in conjunction with GnRH-a.
Edelstein
M C
MC
Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507.
Brzyski
R G
RG
Jones
G S
GS
Simonetti
S
S
Muasher
S J
SJ
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D008596:Menotropins / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D011256:Pregnancy Outcome
D010906:Pituitary Hormone-Releasing Hormones; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone