Mixed acenannellated metallotetraazaporphins: a new class of amphiphilic photosensitizers for the photodynamic therapy of cancer.
The first synthesis of amphiphilic mixed acenannellated metallotetraazaporphins compounds, designed with the aim of improving cell membrane penetration, is described and the preliminary results on their photocytotoxicity are presented.
Gaspard
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Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France.
Margaron
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Tempête
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Thi
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D001372:Aza Compounds / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008027:Light; D008665:Metalloporphyrins / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy*; D010777:Photochemistry; D010778:Photochemotherapy / Q000379:methods*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects
D001372:Aza Compounds; D008665:Metalloporphyrins; D011838:Radiation-Sensitizing Agents