title: Cognitive effects of valproate.
abstract: The effects of valproate on cognition are usually considered to be minimal, but few formal neuropsychological studies are available. We studied the psychomotor performances of 20 seizure-free epileptics during fixed valproate monotherapy and after its withdrawal. Our findings suggest some adverse effects of valproate which appear to be completely reversible after withdrawal.
authors.affiliation: Institute of Neurology, University of Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gallassi
authors.forename: A
authors.initials: A
authors.lastname: Morreale
authors.forename: S
authors.initials: S
authors.lastname: Lorusso
authors.forename: G
authors.initials: G
authors.lastname: Procaccianti
authors.forename: E
authors.initials: E
authors.lastname: Lugaresi
authors.forename: A
authors.initials: A
authors.lastname: Baruzzi
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid