title: Inhibition of BFU-E in vitro growth and of burst-promoting activity of T lymphocytes by serum of chronic uremic patients receiving hemodialysis.
abstract: The effects of uremic serum on the in vitro growth of normal BFU-E and on the burst-promoting activity by normal T-lymphocytes were evaluated separately. The effect of hemodialysis on the removal of possible serum inhibitor(s) was also tested. Sera of 12 uremic patients were shown to provoke a 60% inhibition of the in vitro growth of normal BFU-E and almost complete abolition of burst-promoting activity by T lymphocytes. While hemodialysis significantly removed the inhibition of uremic sera on BFU-E growth, it was rather ineffective in removing the inhibitor(s) of T lymphocytes. The different effects of uremic serum on BFU-E and on T lymphocytes are discussed.
authors.affiliation: Istituto Scientifico di Medicina Interna, Università di Genova, Italia.
authors.forename: L
authors.initials: L
authors.lastname: Morra
authors.forename: A
authors.initials: A
authors.lastname: Ponassi
authors.forename: F
authors.initials: F
authors.lastname: Moccia
authors.forename: G
authors.initials: G
authors.lastname: Gurreri
authors.forename: G
authors.initials: G
authors.lastname: Bessone
authors.forename: G S
authors.initials: GS
authors.lastname: Mela
authors.forename: C
authors.initials: C
authors.lastname: Sacchetti
mesh_terms: D000328:Adult; D000368:Aged; D002455:Cell Division; D002469:Cell Separation / Q000379:methods; D002908:Chronic Disease; D003114:Colony-Forming Units Assay / Q000379:methods; D015672:Erythroid Precursor Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000502:physiology*; D014511:Uremia / Q000097:blood* / Q000628:therapy