title: Penetration of ciprofloxacin into the aqueous humour of the uninflamed human eye after oral administration.
abstract: One hundred and one patients received oral ciprofloxacin prior to elective cataract removal. The quinolone content of the aqueous humour ranged from 2.7% to 15.4% of the corresponding serum level. The mean aqueous peak exceeded 0.4 mg/l between 2 and 3.5 h after administration. The highest aqueous concentration was achieved with a 1 g dose. In uninflamed eyes oral ciprofloxacin achieved intraocular concentrations that are bactericidal for Gram-negative bacteria including Pseudomonas aeruginosa. It may prove useful in the treatment of established intraocular infection and in prophylaxis prior to silastic implants.
authors.affiliation: Bacteriology Department, Southern General Hospital, Glasgow, UK.
authors.forename: G
authors.initials: G
authors.lastname: Sweeney
authors.forename: A I
authors.initials: AI
authors.lastname: Fern
authors.forename: G
authors.initials: G
authors.lastname: Lindsay
authors.forename: M W
authors.initials: MW
authors.lastname: Doig
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D002939:Ciprofloxacin