Carcinogenesis induced by black pepper (Piper nigrum) and modulated by vitamin A.
Painting and feeding of mice with 2mg of an extract from black pepper on 3 days a week for 3 months results in a significant increase of the number of tumor-bearing mice. Tumor incidence is reduced in those groups of experimental animals receiving 5 or 10mg Vitamin A-palmitate twice weekly for 3 months by feeding or painting during and subsequent to application of pepper extract. Feeding of mice with powder of black pepper in diet (50g/3kg food) has no impact on carcinogenesis.
Shwaireb
M H
MH
Zoology Department, Faculty of Science, Alexandria University, Egypt.
Wrba
H
H
el-Mofty
M M
MM
Dutter
A
A
D000284:Administration, Oral; D000818:Animals; D003212:Condiments / Q000633:toxicity; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010936:Plant Extracts / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
D010936:Plant Extracts; D014801:Vitamin A