[Serotonin uptake of thrombocytes as a measure of thrombogenicity of adsorbents].
Serotonin intake into platelets is an active carrier-mediated metabolic achievement. This uptake may be reduced by unphysiological irritation on platelet membrane. Therefore, it is suitable for judgement of thrombogenicity of biomaterials. The 14C serotonin intake after blood contact with various adsorbents was investigated: Haemoresin (GDR), Adsorba 300 C (USSR) and syrendivinylbenzencopolymer FK 1621 (GDR). Only by the latter the serotonin intake was significantly reduced with 72.5 +/- 2.0% in comparison with siliconized glas (84.0 +/- 1.5%; p less than 0.001). Precision and analytical sensitivity of the method are high with a variation coefficient of 1.5 to 3.5%.
Frick
U
U
Institut für Pathologische, Abteilung für Blutspende- und Transfusionswesen.
Möritz
K U
KU
Wiedenhöft
I
I
Frick
G
G
Kraatz
G
G
D000327:Adsorption; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007688:Kidneys, Artificial; D008567:Membranes, Artificial; D010974:Platelet Aggregation / Q000502:physiology*; D012701:Serotonin / Q000097:blood*
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D012701:Serotonin
Serotoninaufnahme der Thrombozyten als Mass für die Thrombogenität von Adsorbentien.