Role of the source of phosphate salt in improving the mineral balance of parenterally fed low birth weight infants.
Because the monobasic potassium phosphate salt (monobasic) improves the solubility of calcium and phosphorus in amino acid plus dextrose solutions, compared with the current mixtures of monobasic plus dibasic salts (dibasic), we tested the bioavailability and clinical effects of monobasic in 16 parenterally fed low birth weight infants at standard (n = 8) and high levels (n = 8) of mineral intakes. A constant infusion of macronutrients and vitamin D was provided in a crossover design of two four-day periods. With standard intakes of calcium (35 mg/kg/day, 0.9 mmol/kg/day) and phosphorus (30 mg/kg/day, 1 mmol/kg/day), there was no difference between monobasic and dibasic regimens on balance data or plasma biochemical monitoring (calcium, phosphorus, pH, carbon dioxide pressure, base excess, 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D). With the use of the monobasic regimen, the mineral intakes were doubled without precipitation in the infusate: calcium, 70 mg/kg/day (1.8 mmol/kg/day), and phosphorus, 55 mg/kg/day (1.7 mmol/kg/day). This led to increased apparent retention of both calcium (63 +/- 5 mg/kg/day, 1.58 +/- 0.12 mmol/kg/day) and phosphorus (52 +/- 4 mg/kg/day, 1.67 +/- 0.14 mmol/kg/day) compared with that for standard levels of mineral intake. The improvement of calcium-phosphorus balance was accompanied by more severe calciuria (9 +/- 2 mg/kg/day, 0.2 +/- 0.05 mmol/kg/day) and by metabolic compensation for an increased acid load. In addition to the possibility of exceeding the buffering capacity of the infant, this relative acidosis could also be evidence of improved bone mineralization.
Chessex
P
P
Centre de recherche, Hôpital Sainte-Justine, Montreal, Quebec, Canada.
Pineault
M
M
Brisson
G
G
Delvin
E E
EE
Glorieux
F H
FH
D000596:Amino Acids / Q000008:administration & dosage; D002118:Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005865:Gestational Age; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight / Q000378:metabolism* / Q000652:urine; D007231:Infant, Newborn; D010289:Parenteral Nutrition, Total; D010710:Phosphates / Q000494:pharmacology*; D010758:Phosphorus / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D011188:Potassium / Q000494:pharmacology*; D017680:Potassium Compounds; D012995:Solubility
D000596:Amino Acids; D010710:Phosphates; D017680:Potassium Compounds; D010758:Phosphorus; C013216:potassium phosphate; D005947:Glucose; D011188:Potassium; D002118:Calcium