Can premature luteinization in superovulation protocols be prevented by aspiration of an ill-timed leading follicle?
In 12 patients stimulated for in vitro fertilization and embryo transfer (IVF-ET), a single leading follicle developed, whereas the other follicles were 6 mm smaller. In 7 patients chosen at random (group A), the leading follicle was aspirated, whereas in the other 5 the leading follicle was allowed to continue growing (group B). Comparison of the hormonal pattern of both groups showed that a premature luteinizing hormone (LH) surge was avoided only in group A, and only in this group a second follicle aspiration for IVF-ET was done, and two pregnancies were achieved. In group B, aspiration for IVF-ET was canceled because of premature LH surge. It is suggested that aspiration of a single leading follicle during ovulation induction may be an efficient method to avoid premature LH surge enabling other follicles to develop up to the preovulatory stage.
Barash
A
A
Kaplan Hospital, Rehovot, Israel.
Shoham
Z
Z
Lunenfeld
B
B
Segal
I
I
Insler
V
V
Borenstein
R
R
D000328:Adult; D003338:Corpus Luteum / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle; D010060:Ovulation / Q000502:physiology*; D013396:Suction; D013480:Superovulation / Q000502:physiology*; D013997:Time Factors
D012739:Gonadal Steroid Hormones; D008596:Menotropins