Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.
The t(5;14)(q31;q32) translocation from B-lineage acute lymphocytic leukemia with eosinophilia has been cloned from two leukemia samples. In both cases, this translocation joined the IgH gene and the interleukin-3 (IL-3) gene. In one patient, excess IL-3 mRNA was produced by the leukemic cells. In the second patient, serum IL-3 levels were measured and shown to correlate with disease activity. There was no evidence of excess granulocyte/macrophage colony stimulating factor (GM-CSF) or IL-5 expression. Our data support the formulation that this subtype of leukemia may arise in part because of a chromosome translocation that activates the IL-3 gene, resulting in autocrine and paracrine growth effects.
Meeker
T C
TC
Department of Medicine, University of California, San Francisco.
Hardy
D
D
Willman
C
C
Hogan
T
T
Abrams
J
J
D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D003001:Cloning, Molecular; D003115:Colony-Stimulating Factors / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D004802:Eosinophilia / Q000209:etiology*; D005091:Exons; D015870:Gene Expression; D015321:Gene Rearrangement; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007377:Interleukin-3 / Q000235:genetics*; D015848:Interleukin-5 / Q000235:genetics; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis; D014178:Translocation, Genetic
D003115:Colony-Stimulating Factors; D004273:DNA, Neoplasm; D006133:Growth Substances; D007143:Immunoglobulin Heavy Chains; D007377:Interleukin-3; D015848:Interleukin-5; D012333:RNA, Messenger; D016178:Granulocyte-Macrophage Colony-Stimulating Factor