The renin-angiotensin system in hypertension: an update.
Although renin and angiotensin are still a puzzle, we are learning where some of the pieces fit. Recent studies indicate that in addition to ameliorating hypertension, ACE inhibitor therapy can prolong life in patients with severe congestive failure. Development of renin inhibitors and angiotensin II receptor antagonists may provide greater therapeutic specificity.
Brunner
H R
HR
Division of Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
D000804:Angiotensin II / Q000502:physiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001920:Bradykinin / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D012083:Renin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D000092502:Renin Inhibitors
D000804:Angiotensin II; D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin; D012083:Renin; D000092502:Renin Inhibitors