[Negative inotropic effect of flecainide on the post-ischemic heart with limited contractile function].
The hemodynamic effects of 7 min i.v. flecainide were examined in rats with postischemic left ventricular dysfunction. For quantification of contractile function the isovolumic left ventricular pressure generating capacity and dp/dtmax were determined. Fifteen min after infusion the isovolumic maximum pressure was reduced for 33 mm Hg after flecainide (2 mg/kg; n = 12), whereas in the controls only a minimal reduction (12 mm Hg; n = 13) was found; dp/dtmax was also significantly reduced after flecainide. The results indicate - in contrast to prior investigations on normal hearts - a considerable negative action of 2 mg/kg flecainide i.v. on postischemic myocardium with reduced contractile function.
Hoffmeister
H M
HM
Medizinische Klinik, Abt. III, Universität Tübingen.
Hörmann
H P
HP
Beyer
M
M
Seipel
L
L
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D005424:Flecainide / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D005424:Flecainide
Negativ inotrope Wirkung von Flecainid bei postischämischen Herzen mit eingeschränkter kontraktiler Funktion.