Liposomes from soya phospholipids as percutaneous drug carriers. 1st communication: qualitative in vivo investigations with antibody-loaded liposomes.
The penetration behaviour of liposome (prepared from NAT 106)-incorporated proteins was investigated in vivo by use of monoclonal antibodies (MOAB) as model substances on the skin of young pigs. Within 20 min of topical application, an even distribution of liposome-incorporated antibodies through all skin layers could be shown by means of an immunohistochemical stain.
Artmann
C
C
Institut für Medizinische Balneologie und Klimatologie, Ludwig-Maximilians-Universität, Munich, Fed. Rep. of Germany.
Röding
J
J
Ghyczy
M
M
Pratzel
H G
HG
D000287:Administration, Topical; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D007150:Immunohistochemistry; D008081:Liposomes / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D012867:Skin / Q000033:anatomy & histology* / Q000378:metabolism; D012869:Skin Absorption; D013025:Glycine max / Q000032:analysis*; D013552:Swine
D000911:Antibodies, Monoclonal; D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids