[The effect of insulin on thrombocytopoiesis and thrombocytopoietin biosynthesis in rats].
The influence of insulin on the number of thrombocytes of male and female rats as well as on the percentage of 75Selenomethionine (75Se-M) incorporated, on bone marrow megakaryocytes and thrombocytopoietic activity of the plasma was studied under normal conditions. It was established that a 3-day administration of insulin induced in both go groups of rats an increase in thrombocyte number, in the percentage of incorporated 75Se-M, in bone marrow megakaryocytes as well as in their total number and in all stages from I to IV with shift to mature cellular forms (III and IV stages). The thrombocytopoietic activity of the plasma was raised as well. In conclusion it could be said that insulin stimulates strongly thrombocytopoiesis in rats as it raises considerably the biosynthesis of its specific humoral regulator thrombocytopoietin. This effect of insulin does not demonstrate sex dependence.
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D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008533:Megakaryocytes / Q000166:cytology / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013926:Thrombopoietin / Q000096:biosynthesis / Q000187:drug effects*
D007328:Insulin; D013926:Thrombopoietin
Vliianie insulina vŭrkhu trombotsitopoezata i biosintezata na trombotsitopoetin u plŭkhove.