title: [Human fetal homograft to the nigrostriatal system for the treatment of Parkinson's disease].
abstract: Four cases of transplant to the brain (striatum) of the ventral mesencephalic area (VMA) and three adrenal glands (A) to patients with Parkinson's disease are described as a new alternative for the improvement of this disease. The patients who received VMA showed a very significant improvement in the rigidity, bradykinesia, alterations in walking and posture, as well as the facial expression. Three of the four patients have returned to work. The group that received A tissue, showed a discreet improvement in the rigidity and bradykinesia, but none in the other signs of the disease. These patients are able to accomplish their daily needs, but two are unable to return to work. The differences which we observed between patients receiving VMA and A transplants, might be related to the heterogeneity of the disease, although we believe that the type of graft was responsible of these differences. Our results with the use of VMA, as well as that of other groups, are encouraging, although it is important to clearly establish that it is a procedure which is still in an experimental phase, requiring caution, and should only be practiced in highly qualified centers of clinical research.
authors.affiliation: Unidad de Investigación Clínica en Neurología y Neurocirugía, IMSS, México, D.F.
authors.forename: I
authors.initials: I
authors.lastname: Madrazo
authors.forename: R
authors.initials: R
authors.lastname: Franco-Bourland
authors.forename: F
authors.initials: F
authors.lastname: Ostrosky
authors.forename: M
authors.initials: M
authors.lastname: Aguilera
authors.forename: C F
authors.initials: CF
authors.lastname: Cuevas
authors.forename: H
authors.initials: H
authors.lastname: Castrejón
authors.forename: G
authors.initials: G
authors.lastname: Guízar-Sahagún
authors.forename: E
authors.initials: E
authors.lastname: Magallon
mesh_terms: D000311:Adrenal Glands / Q000196:embryology / Q000637:transplantation*; D000328:Adult; D000368:Aged; D016380:Brain Tissue Transplantation; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005260:Female; D016332:Fetal Tissue Transplantation; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000601:surgery*
chemical_list: D003524:Cyclosporins; D007980:Levodopa
vernacular_title: El homotrasplante fetal humano al sistema nigroestriado para el tratamiento de la enfermedad de Parkinson.