Physico-chemical characterization of a new salt of ibuprofen.
A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of -8.84 kcal mol-1.
Suleiman
M S
MS
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid.
Najib
N M
NM
Hassan
M A
MA
Abdel-Hamid
M E
ME
D002082:Butylamines / Q000737:chemistry; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002855:Chromatography, Thin Layer; D003460:Crystallization; D007052:Ibuprofen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008853:Microscopy / Q000379:methods; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D002082:Butylamines; C025397:tert-butylamine; D007052:Ibuprofen