title: Hemolysin is required for extraintestinal dissemination of Listeria monocytogenes in intragastrically inoculated mice.
abstract: In this study we demonstrated that a hemolytic strain of Listeria monocytogenes, but not a nonhemolytic mutant derived from it, translocated in substantial numbers to the mesenteric lymph nodes, spleen, and liver after intragastric inoculation of mice. Growth at 4 degrees C prior to inoculation did not increase the virulence of the nonhemolytic mutant. These results indicate that hemolytic activity is required for the virulence of L. monocytogenes via the gastrointestinal tract, as has been shown previously for parenteral challenge.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
authors.forename: J T
authors.initials: JT
authors.lastname: Roll
authors.forename: C J
authors.initials: CJ
authors.lastname: Czuprynski
mesh_terms: D000818:Animals; D006460:Hemolysin Proteins / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology*; D008089:Listeria monocytogenes / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D008088:Listeriosis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009928:Organ Specificity; D014774:Virulence
chemical_list: D006460:Hemolysin Proteins