title: Physico-chemical characterization of a new salt of ibuprofen.
abstract: A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of -8.84 kcal mol-1.
authors.affiliation: Faculty of Pharmacy, Jordan University of Science and Technology, Irbid.
authors.forename: M S
authors.initials: MS
authors.lastname: Suleiman
authors.forename: N M
authors.initials: NM
authors.lastname: Najib
authors.forename: M A
authors.initials: MA
authors.lastname: Hassan
authors.forename: M E
authors.initials: ME
authors.lastname: Abdel-Hamid
mesh_terms: D002082:Butylamines / Q000737:chemistry; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002855:Chromatography, Thin Layer; D003460:Crystallization; D007052:Ibuprofen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008853:Microscopy / Q000379:methods; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D002082:Butylamines; C025397:tert-butylamine; D007052:Ibuprofen