[Candida esophagitis treated with a single dose of fluconazole in patients with HIV: presentation of 11 cases].
We have reviewed the efficacy of the use of fluconazole in patients with definitely proven Candida esophagitis (CE) associated with human immunodeficiency virus (HIV) infection, using a single 400 mg oral dose of fluconazole and evaluating the patient three days afterwards. This drug showed to be effective for the clinical and endoscopic cure in all patients (100%), and with microbiological cure in ten cases. There was no clinical feature of toxicity. The only side effect was an increased alkaline phosphatase and transaminase activity without hyperbilirubinemia, but this finding was not statistically significant (p greater than 0.05). Fluconazole, given in a single 400 mg dose, was absolutely effective to cure esophagitis in AIDS, thus permitting to avoid parenteral amphotericin.
Roig
P
P
Sección de Enfermedades Infecciosas, Hospital General Universitario de Valencia.
Martínez
A
A
Salavert
M
M
Nieto
A
A
Navarro
V
V
Medina
E
E
Carrasco
R
R
D000328:Adult; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D004941:Esophagitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012008:Recurrence
D015725:Fluconazole
La esofagitis candidiásica con dosis única de fluconazol en pacientes con VIH: presentación de 11 casos.