title: [The usefulness of event-related negativity in demonstrating the therapeutic effects of nootropic drugs using cerebrolysin as an example].
abstract: This study investigated the usefulness of the Contingent Negative Variation (CNV) in the assessment of therapeutic efficacy of a nootropic substance, Cerebrolysin. A total of 41 geriatric patients with the diagnosis of moderate organic brain syndrome of different etiology were included in this randomized placebo-controlled double-blind study. After ten Cerebrolysin- plus multi-vitamins-Infusions, the treatment group of 27 patients showed a significant CNV-amplitude increase as compared to pre-treatment values. In the placebo group of 14 patients CNV-amplitudes even decreased after ten Infusions with multi-vitamins alone. These findings were interpreted in line with the vigilance model of nootropic drug effects as a vigilance-increasing effect of Cerebrolysin, i.e. as an increased neuronal performance readiness. The results confirmed the usefulness of the CNV method by providing an EEG-index of nootropic drug effects.
authors.affiliation: Institut für Forensische Psychiatrie, Universität und Neuropsychogeriatrische Abteilung.
authors.forename: B
authors.initials: B
authors.lastname: Kofler
authors.forename: C
authors.initials: C
authors.lastname: Erhart
authors.forename: P
authors.initials: P
authors.lastname: Erhart
authors.forename: G
authors.initials: G
authors.lastname: Harrer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000627:therapeutic use*; D003265:Contingent Negative Variation / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy*
chemical_list: D000596:Amino Acids; C006952:cerebrolysin
vernacular_title: Die Brauchbarkeit der ereigniskorrelierten Negativität zum Nachweis therapeutischer Wirkungen von Nootropika am Beispiel von Cerebrolysin.