Role of HLA class II molecules expressed on hematopoietic progenitor cells.
The fixation of monoclonal antibodies (MoAb) to the molecule HLA-DR induced an augmentation of thymidine uptake by bone marrow cells, an increased formation of granulo-monocytic colonies and the activation of membrane phospholipase C (PLC) in hematopoietic progenitor cell (HPC) population. The molecule DR expressed on HPC is therefore implicated in signal transduction leading to hematopoietic differentiation.
Mascle
F
F
Laboratoire d'Immunogénétique Moléculaire, Institut des Cordeliers, Paris, France.
Mooney
N
N
Devergie
A
A
Gluckman
E
E
Charron
D
D
D000911:Antibodies, Monoclonal; D002455:Cell Division / Q000276:immunology; D003114:Colony-Forming Units Assay; D006681:HLA-D Antigens / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D010738:Type C Phospholipases / Q000378:metabolism
D000911:Antibodies, Monoclonal; D006681:HLA-D Antigens; D010738:Type C Phospholipases