Carcinoma in situ of the cervix and its malignant potential. A lesson from New Zealand.
An overview of studies attempting to define the natural history of carcinoma in situ of the cervix suggests that 20-30% of lesions progress to invasive carcinoma within 5-10 years. This risk of invasion and the inability to predict when invasion might occur has been reinforced by a judicial enquiry in New Zealand so that protocols that include withholding treatment are no longer justifiable. Once a diagnosis of cervical carcinoma in situ is established appropriate treatment is mandatory.
Chang
A R
AR
Department of Pathology, University of Otago Medical School, Dunedin, New Zealand.
D002277:Carcinoma / Q000473:pathology / Q000517:prevention & control*; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007258:Informed Consent; D008403:Mass Screening; D009361:Neoplasm Invasiveness; D009520:New Zealand / Q000453:epidemiology; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy