Effect of antibodies to human seminal plasma inhibin on spermatogenesis and sperm agglutination in adult male rats.
In vitro incubation of rat epididymal sperm with antiserum to human seminal plasma inhibin (As hSPI) caused agglutination of the sperm. In vivo administration of As hSPI to adult male rats resulted in a significant decrease in testicular as well as epididymal sperm counts. Furthermore, the majority (almost 90%) of the epididymal sperm were agglutinated. When these animals were mated with normal cycling females, significant reduction in fertility was observed.
Vanage
G R
GR
Institute for Research in Reproduction (ICMR), Bombay, India.
Gopalkrishnan
K
K
Sheth
A R
AR
D000818:Animals; D000906:Antibodies; D005298:Fertility; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007265:Inhibins / Q000037:antagonists & inhibitors / Q000276:immunology; D008297:Male; D051381:Rats; D012661:Semen / Q000276:immunology*; D012671:Seminiferous Tubules / Q000033:anatomy & histology / Q000276:immunology; D013073:Sperm Agglutination / Q000276:immunology*; D013076:Sperm Count; D013091:Spermatogenesis / Q000276:immunology*; D013737:Testis / Q000033:anatomy & histology / Q000276:immunology
D000906:Antibodies; D007265:Inhibins; D005640:Follicle Stimulating Hormone