Protective action of coenzyme A on paracetamol-induced tissue depletion of glutathione.
Paracetamol toxicity induced in mice a significant depletion in hepatic and renal glutathione concentrations. The administration of CoA in animals prevents the mortality induced by paracetamol and simultaneously prevents the reduction in renal and hepatic glutathione concentrations.
Bertelli
A
A
Department of Pharmacology, Chemotherapy and Medical Toxicology, Milan University, Italy.
Bertelli
A A
AA
Giovannini
L
L
Mian
M
M
Spaggiari
P
P
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D003065:Coenzyme A / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000032:analysis / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D000082:Acetaminophen; D005978:Glutathione; D003065:Coenzyme A