[Thyroid myopathy. Effect of treatment with thyroid hormones].
We studied 20 patients afflicted with primary hypothyroidism and treated with thyroid hormone replacements, with the aim of evaluating the clinical, biochemical, EMG and anatomo-pathological effects. Cramps, as well as subjective and objective proximal muscular weakness, disappeared. Seric CPK was normalized in all cases after 1-8 weeks of treatment. EMG myopathic patterns faded away in all cases. Anatomopathological changes took longer to observe; 5 cases with new biopsy showed an isolate atrophy of type II fibers, one of them after 18 months in treatment; type I fibers had mitochondrial accumula without change compared to the initial biopsy. There was a clear tendency for the destroyed fibers to become normalized and for the structures similar to the "core" to vanish.
del Palacio
A
A
Servicio de Medicina Interna, Hospital 12 de Octubre, Madrid.
Trueba
J L
JL
Cabello
A
A
Gutiérrez
E
E
Moya
I
I
Fernández Miranda
C
C
García Albea
E
E
Ricoy
J R
JR
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D013963:Thyroid Hormones / Q000627:therapeutic use*
D013963:Thyroid Hormones
Miopatía tiroidea. Efecto del tratamiento con hormonas tiroideas.