title: A non-hormonal therapeutic alternative in cervico-vaginal dystrophies.
abstract: The pharmaco therapeutic effect of polydeoxyribonucleotide vaginal suppositories in two dosages (PDRN 1,65 mg and PDRN 5 mg)* on vaginal dystrophy was studied. 40 women, aged more than forty, in surgical or physiological climacteric with cervico-vaginal dystrophy were examined. The study was carried out according to the double-blind method, randomized, between groups. Both treatments produced important ameliorations of subjective symptomatology and objective signs. No significant difference emerged between the two preparations. PDRN was proved to be a valid alternative to local hormonal therapies.
authors.affiliation: Divisione Ostetrico Ginecologica, Ospedale di Livorno.
authors.forename: M P
authors.initials: MP
authors.lastname: Maresi
authors.forename: L
authors.initials: L
authors.lastname: Baldi
authors.forename: L
authors.initials: L
authors.lastname: Balatresi
authors.forename: G
authors.initials: G
authors.lastname: Bogi
authors.forename: T
authors.initials: T
authors.lastname: Civello
authors.forename: A
authors.initials: A
authors.lastname: Cosimi
authors.forename: R
authors.initials: R
authors.lastname: De Santis
authors.forename: M
authors.initials: M
authors.lastname: Guarnotta
authors.forename: F
authors.initials: F
authors.lastname: Baisi
authors.forename: A
authors.initials: A
authors.lastname: Parente
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D011089:Polydeoxyribonucleotides / Q000008:administration & dosage*; D013488:Suppositories; D002577:Uterine Cervical Diseases / Q000188:drug therapy* / Q000473:pathology; D014621:Vagina / Q000473:pathology; D014623:Vaginal Diseases / Q000188:drug therapy* / Q000473:pathology; D014626:Vaginal Smears
chemical_list: D011089:Polydeoxyribonucleotides; D013488:Suppositories