title: Prevalence of novel repeat sequences in and around the P1 operon in the genome of Mycoplasma pneumoniae.
abstract: The presence of numerous different repetitive elements in the genome of Mycoplasma pneumoniae has been documented by several laboratories. One which we previously identified, denoted as SDC1, has now been further characterized, verified to be distinct from those discussed in previous publications and shown to lack homology to several other species of Mycoplasma when tested under our stringency conditions. As many as eight versions of the SDC1-type repeat, which is more than 400 bp long, are scattered throughout the genome of M. pneumoniae. The prototype for SDC1 is found within a gene encoding a putative 130-kDa membrane-binding protein lying just downstream from the gene encoding the cytadhesin protein P1. In fact, all of the reported M. pneumoniae repetitive elements have at least one representative either within or adjacent to the P1 operon; many if not all of these lie within open reading frames. The function of these repetitive elements is still unclear.
authors.affiliation: Curriculum in Genetics, University of North Carolina School of Medicine, Chapel Hill 27599.
authors.forename: S D
authors.initials: SD
authors.lastname: Colman
authors.forename: P C
authors.initials: PC
authors.lastname: Hu
authors.forename: K F
authors.initials: KF
authors.lastname: Bott
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009177:Mycoplasma pneumoniae / Q000235:genetics*; D009876:Operon; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004269:DNA, Bacterial