Inducible expression of the proto-oncogene c-fos in transgenic mice.
We have generated transgenic mouse lines expressing the proto-oncogene c-fos under the control of the interferon inducible Mx promotor. We found low expression in skeletal muscle, brain and salivary glands and a very high expression in spleen, liver, thymus, heart and kidney. Despite this transgenic c-fos expression we have not yet detected any phenotypic changes in these mouse lines.
Bachiller
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European Molecular Biology Laboratory, Heidelberg, FRG.
Rüther
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U
D000818:Animals; D000998:Antiviral Agents / Q000235:genetics; D019204:GTP-Binding Proteins; D005786:Gene Expression Regulation; D051379:Mice; D008822:Mice, Transgenic; D064547:Myxovirus Resistance Proteins; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos
D000998:Antiviral Agents; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D019204:GTP-Binding Proteins