title: Treatment of hyperstimulation during in-vitro fertilization.
abstract: In 33 patients treated with a combination of an LHRH agonist (LHRH-A) and gonadotrophin in a long protocol, a biological hyperstimulation occurred (E2 greater than 2500 pg/ml on the day of HCG administration and 4722 +/- 1190 pg/ml the day after, with greater than 10 follicles greater than 12 mm on each ovary). The replacement of fresh embryos were deferred and LHRH-A was continued, and an endometrial biopsy was performed on the theoretical day of replacement (2 days after oocyte recovery). With this technique, we obtained a mean number of 17.9 +/- 7 oocytes, a fertilization rate of 49% and a replacement rate of 87% in a deferred cycles. The overall pregnancy rate of frozen-thawed embryos was 27% in the seven spontaneous cycles, 12 induced cycles and 10 artificial cycles. Only one severe hyperstimulation occurred and this case emphasizes that caution remains necessary even with this technique.
authors.affiliation: Department of Obstetrics and Gynaecology, Hôpital Tenon, University Paris VI, France.
authors.forename: J
authors.initials: J
authors.lastname: Salat-Baroux
authors.forename: S
authors.initials: S
authors.lastname: Alvarez
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: D
authors.initials: D
authors.lastname: Cornet
authors.forename: C
authors.initials: C
authors.lastname: Tibi
authors.forename: M
authors.initials: M
authors.lastname: Plachot
authors.forename: J
authors.initials: J
authors.lastname: Mandelbaum
mesh_terms: D004624:Embryo Transfer; D004958:Estradiol / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D010060:Ovulation; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000627:therapeutic use; D013480:Superovulation
chemical_list: D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone