[Selection by means of KB cells of substances and extracts potentially active in cancer chemotherapy].
Several synthetic, semi-synthetic and natural compounds as well as plant extracts were screened for their growth inhibition activity on KB cells. The most active ones were naphthoquinones and derivatives of pyrido [4,3-b]carbazole alkaloids, with inhibition dose (ID50) less than 4 micrograms/ml. Of the crude extracts of several plants screened, Vellozia caput-ardeae showed to be the most active.
Fávaro
O C
OC
Seção de Farmacologia, Instituto Biológico, São Paulo.
De Oliveira
M M
MM
Rossini
M A
MA
Kamakura
C R
CR
Pinto
A V
AV
Pinto
M do C
Mdo C
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007624:KB Cells
D000972:Antineoplastic Agents, Phytogenic
Seleção por meio de células KB de substâncias e extratos potencialmente ativos em quimioterapia do câncer.