Effect of CGS 9896 on stress-induced gastric ulcer in rat.
1. The effects of CGS 9896, a partial benzodiazepine agonist, and chlordiazepoxide, a full benzodiazepine agonist, on stress-induced gastric ulcers as well as blood glucose were compared. 2. Ulceration in the glandular stomach was induced by 2 h restraint at 4 degrees C. 3. CGS 9896 reduced significantly the ulcer parameters but did not affect blood glucose. The effect of CGS 9896 was dose-dependently blocked by the benzodiazepine antagonist flumazepil. 4. Chlordiazepoxide reduced the ulcer parameters but increased blood glucose. 5. Since CGS 9896 lacks sedative effects but reduced ulcer parameters, the anti-ulcer and sedative effects of drugs acting at benzodiazepine receptors are disassociated. 6. Benzodiazepine-induced hyperglycaemia does not play a major role in the anti-ulcer effects.
Najim
R A
RA
Department of Pharmacology, College of Medicine, University of Baghdad, Iraq.
Karim
K H
KH
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology; D003080:Cold Temperature; D004359:Drug Therapy, Combination; D005442:Flumazenil / Q000494:pharmacology; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy*; D013312:Stress, Physiological
D011720:Pyrazoles; D001569:Benzodiazepines; D005442:Flumazenil; D002707:Chlordiazepoxide; C034704:2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one