Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis.
The effects of FUT-187 (6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate, CAS 103926-82-5), a novel synthetic protease inhibitor, were examined in experimental rat and canine models of pancreatitis. 1. FUT-187 significantly increased the survival of rats with trypsin- and phospholipase A2-induced pancreatitis in a dose-dependent manner (10-100 mg/kg, p.o.). 2. FUT-187 decreased plasma enzymatic activity reflecting the degree of pancreatitis in rats with ethionine-induced pancreatitis, and showed a tendency to ameliorate histopathological changes in the pancreas (10-100 mg/kg p.o.). 3. FUT-187 (10 mg/kg) produced an obvious improvement of various biochemical parameters of pancreatitis and also reduced histopathological changes in the pancreas in animals with experimental pancreatitis produced by the closed duodenal loop method. In addition, FUT-187 significantly increased the survival of dogs when given by direct administration into the lumen of the closed duodenal loop. The therapeutic effects of FUT-187 in experimental pancreatitis were nearly equal in most instances to those of camostat mesilate. Thus, FUT-187 would appear to be an effective new agent for the treatment of pancreatitis.
Murakami
H
H
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
Togawa
M
M
Takahashi
S
S
Kasahara
N
N
Yamamoto
J
J
Matsuura
N
N
Koshiyama
Y
Y
Ino
Y
Y
Oda
M
M
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D005001:Ethionine / Q000494:pharmacology; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010741:Phospholipases A; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin
D007093:Imidazoles; C058875:sepimostate mesilate; D010741:Phospholipases A; D054467:Phospholipases A2; D014357:Trypsin; D005001:Ethionine