Heterogeneity of pseudohypoparathyroidism type I from the aspect of urinary excretion of calcium and serum levels of parathyroid hormone.
Urinary excretion of calcium (Ca) was measured in 9 patients with pseudohypoparathyroidism (PHP) type I--3 with Albright's hereditary osteodystrophy (AHO): AHO(+) and 6 without AHO: AHO(-)--and in 13 with idiopathic hypoparathyroidism (IHP), treated with active vitamin D3 (1,25(OH)2D3 or 1 alpha OHD3) to maintain serum Ca levels at 8.4-9.5 mg/dl. Fasting urinary excretion of Ca in PHP was significantly lower than that in IHP. Moreover, fasting urinary excretion of Ca in PHP AHO(+) was lower than that in PHP AHO(-). This difference was also seen in the urine after oral loading of Ca. Urinary excretion of sodium (Na) was not different between PHP AHO(+) and PHP AHO(-). Serum levels of immunoreactive PTH in PHP AHO(+) were higher than those in PHP AHO(-). The difference in urinary excretion of Ca between PHP AHO(+) and PHP AHO(-) may come from the difference in the circulating levels of PTH.
Mizunashi
K
K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Furukawa
Y
Y
Sohn
H E
HE
Miura
R
R
Yumita
S
S
Yoshinaga
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000008:administration & dosage / Q000652:urine*; D005215:Fasting; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011547:Pseudohypoparathyroidism / Q000097:blood / Q000145:classification* / Q000652:urine; D012964:Sodium / Q000652:urine
D010281:Parathyroid Hormone; D012964:Sodium; D002118:Calcium