Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/macrophages.
Accumulation of ornithine decarboxylase (ODC) mRNA was investigated in human monocytes and mouse peritoneal macrophages. Treatment of both populations of mononuclear phagocytes with bacterial lipopolysaccharide induced a marked and rapid increase in the accumulation of the ODC gene transcript. A similar phenomenon, albeit less pronounced, was also observed following treatment of human monocytes with human recombinant interferon-gamma. These results suggest a role for ODC, and therefore polyamines, in the regulation of mononuclear phagocyte functions.
Messina
L
L
Institute of General Pathology, University of Catania, Italy.
Arcidiacono
A
A
Spampinato
G
G
Malaguarnera
L
L
Berton
G
G
Kaczmarek
L
L
Messina
A
A
D000818:Animals; D015152:Blotting, Northern; D002478:Cells, Cultured; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D009000:Monocytes / Q000502:physiology*; D009955:Ornithine Decarboxylase / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D011994:Recombinant Proteins
D008070:Lipopolysaccharides; D012333:RNA, Messenger; D011994:Recombinant Proteins; D007371:Interferon-gamma; D009955:Ornithine Decarboxylase