Switch-function of amino sugar on elsamicin A, a DNA binding antitumor antibiotic.
There are a considerable number of DNA binding natural products equipped with amino sugar residues. The amino sugar of elsamicin A significantly takes part in DNA binding and antitumor activity. In addition, we found that an acetylation of the amino group on elsamicin A sugar portion plays an important switch-function for the activity of elsamicin A. The biological implication of this switch has been discussed.
Uesugi
M
M
Institute for Chemical Research, Kyoto University, Japan.
Sugiura
Y
Y
D000107:Acetylation; D000606:Amino Sugars / Q000737:chemistry* / Q000378:metabolism; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001578:Benzopyrans; D004249:DNA Damage; D004270:DNA, Circular / Q000378:metabolism; D004278:DNA, Superhelical / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D006027:Glycosides; D015394:Molecular Structure
D000606:Amino Sugars; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D004270:DNA, Circular; D004278:DNA, Superhelical; D006027:Glycosides; C002185:chartreusin; C049904:elsamicin A