title: [Hemodynamic adaptation during extracorporeal perfusion and arteriovenous extracorporeal CO2 removal].
abstract: During an animal study using five bastard dogs the hemodynamic relations during extracorporeal perfusion with an arteriovenous circuit and extracorporeal CO2 removal (ECCO2-R) were analyzed. We utilised a prototype circuit (Promed, West-Germany) which is by diminution and using silicon rubber adapted to the application in newborn. A silicon lung (Scimed, 0.8 m2, ECCO2-R) was used in the circuit. During the six hours perfusion period a main arterial blood pressure of 83 +/- 17 mmHg and an extracorporeal blood flow of 412 +/- 56 ml/min was found using arteriovenous perfusion via the femoral artery and vein. We found a statistical significant correlation (r = 0.66) between the main arterial blood pressure and the extracorporeal blood flow. Further more there was a significant correlation between the arterial PCO2 and the blood flow through membrane lung (r = 0.81). In conclusion our animal experiments approved the possibility of hemodynamic adaptation to an arteriovenous circuit as well as effectiveness of CO2 removal via such circuit.
authors.affiliation: Universitäts-Frauenklinik Bonn.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: K A
authors.initials: KA
authors.lastname: Hultquist
authors.forename: L
authors.initials: L
authors.lastname: Bindl
authors.forename: S
authors.initials: S
authors.lastname: Gorissen-Bosselmann
authors.forename: R H
authors.initials: RH
authors.lastname: Bartlett
authors.forename: D
authors.initials: D
authors.lastname: Krebs
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood*; D004285:Dogs; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D008567:Membranes, Artificial; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012828:Silicones
chemical_list: D008567:Membranes, Artificial; D012828:Silicones; D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Hämodynamische Adaptation während extrakorporaler Perfusion und Arteriovenösem ECCO2-R.