Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.
The activity of recombinant gamma interferon (rIFN-gamma) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis. Mice received either pyrimethamine or clindamycin alone or in combination with rIFN-gamma. Significantly increased survival and/or time to death was observed in animals treated with pyrimethamine or clindamycin in combination with rIFN-gamma compared to those that received treatment with any of the agents alone.
Israelski
D
D
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.
Remington
J
J
D000818:Animals; D002981:Clindamycin / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D007371:Interferon-gamma / Q000627:therapeutic use*; D051379:Mice; D011739:Pyrimethamine / Q000627:therapeutic use*; D011994:Recombinant Proteins; D015996:Survival Rate; D013997:Time Factors; D014124:Toxoplasmosis, Animal / Q000188:drug therapy* / Q000401:mortality
D004338:Drug Combinations; D011994:Recombinant Proteins; D002981:Clindamycin; D007371:Interferon-gamma; D011739:Pyrimethamine