title: Plasma vitamin E response in sheep dosed intraruminally or intraduodenally with various alpha-tocopherol compounds.
abstract: A total of 24 sheep were used to study two routes of vitamin E administration: intraruminal (IR) and intraduodenal (ID). For each route of administration, 12 sheep were divided into 3 groups of 4, and each group received one of the following vitamin E treatments (mg/kg body weight): treatment 1, D-alpha-tocopherol (60 mg); treatment 2, D-alpha-tocopherol acetate (70 mg); treatment 3, DL-alpha-tocopherol (90 mg). The results showed that two major indices of bioavailability, i.e. concentration maximum and the area under the plasma concentration time-curve, were higher following IR administration than ID administration for all three vitamin E compounds used in this experiment. In sheep dosed intraruminally no difference was observed between the three vitamin E preparations in their plasma vitamin E response. For the ID administration the peak of plasma vitamin E concentration was lower after D-alpha-tocopherol acetate dosing than with the other two preparations. The results indicated a beneficial effect of rumen environment on the availability of vitamin E supplements.
authors.affiliation: Animal Research Centre, Agriculture Canada, Ottawa, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Hidiroglou
authors.forename: G
authors.initials: G
authors.lastname: Butler
authors.forename: M
authors.initials: M
authors.lastname: Ivan
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001682:Biological Availability; D001835:Body Weight; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D012417:Rumen / Q000187:drug effects / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*
chemical_list: D014810:Vitamin E