title: Cephradine (Velosef) penetration of mandibular bone.
abstract: The concentration of cephradine in serum and mandibular bone was assayed in 28 patients undergoing 3rd molar surgery following a single 1 g intravenous injection. Serum and cortical bone samples taken simultaneously, contained mean cephradine concentrations of 42.11 micrograms/ml and 2.61 micrograms/g respectively. These results, when compared with those reported for other bony sites including the femoral head and knee, show a reduced bone penetration with a bone-to-serum ratio of approximately 0.06:1.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Turner Dental School, University Dental Hospital of Manchester, England.
authors.forename: R J
authors.initials: RJ
authors.lastname: Middlehurst
authors.forename: J P
authors.initials: JP
authors.lastname: Rood
mesh_terms: D000328:Adult; D002511:Cephalosporins / Q000032:analysis*; D002515:Cephradine / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008334:Mandible / Q000032:analysis*; D008964:Molar, Third / Q000601:surgery; D011292:Premedication; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D002515:Cephradine