Anti-oestrogenic effect of clomiphene citrate in oestrogen-treated, hypogonadal women.
The effect of clomiphene on the pituitary response to exogenous LHRH was investigated in five hypogonadal women during long-term treatment with varying doses of oestrogen. In three of them, basal LH levels were low (less than 10 mIU/ml) and increased significantly after 8 days of treatment with clomiphene (100 mg/day). Clomiphene augmented the LH and FSH response to LHRH (an acute i.v. injection of 100 micrograms) and changed the pattern of response into that seen in the absence of the influence of ovarian steroids. We conclude that clomiphene exerts anti-oestrogenic effects on basal and LHRH-stimulated release of gonadotrophins in hypogonadal women during long-term treatment with oestrogen.
Messinis
I E
IE
Department of Obstetrics and Gynaecology, University of Aberdeen, Foresterhill, UK.
Templeton
A A
AA
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D010902:Pituitary Gland / Q000187:drug effects
D004965:Estrogen Antagonists; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone