title: Stress-induced desensitization of the cardiovascular response to noradrenaline in unanesthetized rats.
abstract: The present study was undertaken in order to analyse the effect of swimming stress on the blood pressure response to noradrenaline (NA) in unanesthetized rats. Swimming induced a desensitization of the blood pressure response to NA which was not blocked by previous animal treatment with prazosin (0.1 mg/kg). However, rats submitted to stress showed increased sensitivity to the prazosin blocking effect. The results suggest that swimming-induced desensitization of the cardiovascular response to NA is mediated by alpha rather than beta-1 adrenoceptors.
authors.affiliation: Departamento de Fisiologia e Biofísica, Universidade Estadual de Campinas, Brasil.
authors.forename: M C
authors.initials: MC
authors.lastname: Martins
authors.forename: R C
authors.initials: RC
authors.lastname: Spadari
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D005082:Physical Exertion / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013550:Swimming
chemical_list: D009638:Norepinephrine; D011224:Prazosin