Treatment failure in trichomoniasis and persistence of the parasite after Lactobacillus immunotherapy; two case reports.
This report describes the clinical and laboratory observations on two patients with a Trichomonas vaginalis infection resistant to metronidazole. The metronidazole resistance was confirmed in in vitro cultures under aerobic conditions, after in vitro cultivation of the strains. Trichomonas infection persisted during high-dose intravenous metronidazole administration and Lactobacillus immunotherapy was unsuccessful in both patients.
van der Weiden
R M
RM
Department of Obstetrics and Gynaecology, St. Franciscus Gasthuis, Rotterdam, The Netherlands.
van der Meijden
W I
WI
Bogchelman
D H
DH
Polderman
A M
AM
D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007779:Lactobacillus acidophilus; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000188:drug therapy / Q000469:parasitology / Q000628:therapy*
D008795:Metronidazole