The effect of praziquantel on the circulating antigen SJ 70 in murine schistosomiasis japonica.
A circulating schistosome 70 kDa antigen (SJ 70) has been detected in the sera of mice infected with Schistosoma japonicum. For the detection of this antigen, a double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was employed. SJ 70 is first detected in the serum of S. japonicum-infected mice 4 weeks after infection. Antigen levels rise rapidly, plateau by 7 weeks after infection, and remain relatively unchanged for at least another 9 weeks. In mice infected with S. japonicum for 7 weeks and then treated with praziquantel (100 mg/kg body weight), there is a significant decrease in serum antigen levels within 2 weeks after treatment, and an almost complete disappearance of antigen from the serum 3-4 weeks after treatment.
Carter
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Vanderbilt University, Nashville, Tennessee.
Fu
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Colley
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D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051379:Mice; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*; D012044:Regression Analysis; D012549:Schistosoma japonicum / Q000187:drug effects / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000276:immunology
D000947:Antigens, Helminth; D011223:Praziquantel