In vitro effect of synthetic flavanoids on astrovirus infection.
In this study we investigated the activity of halogeno-, cyano- and amidino-isoflavenes, isoflavans and flavans on the multiplication of human astroviruses. These are naked small round viruses which have been recognized as causative agents of human gastroenteritis, and whose capsid proteins are similar to those of picornaviruses. Although all drugs tested caused a dose-dependent reduction of viral antigen synthesis as monitored by immunofluorescence, the chloro derivatives were the most effective.
Superti
F
F
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Università di Roma La Sapienza, Italy.
Seganti
L
L
Orsi
N
N
Desideri
N
N
Stein
M L
ML
Tinari
A
A
Marziano
M L
ML
Donelli
G
G
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D005419:Flavonoids / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D007529:Isoflavones / Q000494:pharmacology*; D001257:Mamastrovirus / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D011817:Rabbits; D014777:Virus Diseases / Q000188:drug therapy*; D014713:Viruses, Unclassified / Q000187:drug effects*
D000956:Antigens, Viral; D000998:Antiviral Agents; D005419:Flavonoids; D007529:Isoflavones