[Phenomenon of enzymatic imprinting in adult animals].
An inductor of a system of multifunctional monooxygenases, the sovol, being applied to hepatectomized adult rats, produced an enzymatic imprinting, which was expressed in a long-term increase in the aryl hydrocarbon hydroxylase, 7-ethoxycoumarin-deethylase and amidopyrine-N-demethylase activities, as well as in the metabolic activation of benzo (a)-pyrene by the liver S9-fraction in the Salmonella/microsome assay. The phenomena of enzymatic imprinting in adult animals, primarily described, is a reflection of response universality of proliferative cells upon inductors action.
Khudoleĭ
V V
VV
Mizgirev
I V
IV
Maĭorova
I G
IG
D015660:7-Alkoxycoumarin O-Dealkylase / Q000096:biosynthesis*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001564:Benzo(a)pyrene / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005470:Fluorometry; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology; D051381:Rats
D001564:Benzo(a)pyrene; C053040:Sovol; D011078:Polychlorinated Biphenyls; D015660:7-Alkoxycoumarin O-Dealkylase; D001189:Aryl Hydrocarbon Hydroxylases; D010089:Oxidoreductases, N-Demethylating
Fenomen fermentativnogo imprintinga u vzroslykh zhivotnykh.