title: [Bacteriocholia and cholic acid level in the bile in cholelithiasis].
abstract: Infection of the biliferous system in patients with cholelithiasis was shown to be the most frequent when the levels of cholic acid in bile were low. Physiological concentrations of cholic and deoxycholic acids have antimicrobial activity against organisms not adapted to the presence in bile. Outer drainage of the bile ducts was accompanied by an increase in the levels of cholic acid when at the background of outer decompression bacteria were eliminated from the biliferous system. In vitro studies revealed a synergistic antibacterial effect of cholic and deoxycholic acid combinations with cefazolin.
authors.forename: B M
authors.initials: BM
authors.lastname: Bekbergenov
authors.forename: N A
authors.initials: NA
authors.lastname: Sergeeva
authors.forename: P V
authors.initials: PV
authors.lastname: Podachin
authors.forename: B R
authors.initials: BR
authors.lastname: Gel'fand
authors.forename: M I
authors.initials: MI
authors.lastname: Filimonov
mesh_terms: D001646:Bile / Q000378:metabolism / Q000382:microbiology*; D002437:Cefazolin / Q000494:pharmacology; D002769:Cholelithiasis / Q000378:metabolism / Q000382:microbiology*; D002793:Cholic Acids / Q000378:metabolism*; D003470:Culture Media; D003840:Deoxycholic Acid / Q000378:metabolism*; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D002793:Cholic Acids; D003470:Culture Media; D005839:Gentamicins; D003840:Deoxycholic Acid; D002437:Cefazolin
vernacular_title: Bakteriokholiia i soderzhanie knolevoĭ kisloty v zhelchi pri zhelchnokamennoĭ bolezni.