title: Immunosuppression in caprine trypanosomiasis: effects of acute Trypanosoma congolense infection on antibody response to anthrax spore vaccine.
abstract: Trypanosoma congolense infected goats were vaccinated with Bacillus anthracis spore vaccine to determine the effect of such infection on the humoral immune response to the vaccine. The anti-anthrax antibody levels were severely depressed in infected goats. When trypanocidal therapy was administered to T. congolense infected goats 14 days after infection they developed antibody levels against Bacillus anthracis similar to uninfected controls.
authors.affiliation: Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nairobi, Kenya.
authors.forename: D M
authors.initials: DM
authors.lastname: Mwangi
authors.forename: W K
authors.initials: WK
authors.lastname: Munyua
authors.forename: P N
authors.initials: PN
authors.lastname: Nyaga
mesh_terms: D000208:Acute Disease; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001408:Bacillus anthracis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D005260:Female; D015511:Goat Diseases / Q000097:blood / Q000276:immunology*; D006041:Goats; D006400:Hematocrit / Q000662:veterinary; D007108:Immune Tolerance; D008297:Male; D013171:Spores, Bacterial / Q000276:immunology; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000097:blood / Q000276:immunology / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines