Pre-erythrocytic stage malaria parasites: non-circumsporozoite protein antigens.
A series of non-circumsporozoite proteins found in pre-erythrocytic parasites are being developed as putative vaccine candidates. It is anticipated that these will be useful in addition to, rather than instead of, the CS (circumsporozoite) vaccines. It is likely that a greater understanding of the basic biology of malaria parasite-host relationships will lead to development of improved malarial vaccines.
Hollingdale
M R
MR
Biomedical Research Institute, Rockville, MD 20852.
Aikawa
M
M
Chen
G X
GX
Meis
J F
JF
Sakhuja
K
K
Sina
B
B
Zhu
J D
JD
D000818:Animals; D000953:Antigens, Protozoan / Q000302:isolation & purification*; D000954:Antigens, Surface / Q000302:isolation & purification; D006360:Heat-Shock Proteins / Q000302:isolation & purification; D006801:Humans; D010962:Plasmodium berghei / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000302:isolation & purification
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D006360:Heat-Shock Proteins; D014614:Vaccines, Synthetic