Induction of hepatic tumors with butylated hydroxyanisole in the self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus.
The three-day-old larvae of self-fertilizing hermaphroditic fish Rivulus ocellatus marmoratus were fed a diet containing the antioxidant butylated hydroxyanisole (BHA) at levels of 0.01-0.8% for 12 days. Six months after BHA administration, hepatic tumors were found in all groups of BHA-treated fish. The BHA-induced tumor incidences were clearly dose-dependent. These results show that dietary BHA is hepatocarcinogenic in Rivulus even at 0.01% dose.
Park
E H
EH
Department of Biology, College of Natural Sciences, Hanyang University, Seoul, Korea.
Chang
H H
HH
Cha
Y N
YN
D000818:Animals; D002083:Butylated Hydroxyanisole; D015197:Carcinogenicity Tests; D005399:Fishes; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology
D002083:Butylated Hydroxyanisole