Effects of ofloxacin on cell-mediated immune response and lymphokine production.
The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of gamma-interferon, interleukin-2 and alpha-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in alpha-interferon production were observed, while other parameters remained unaffected by treatment.
Biglino
A
A
Institute of Infectious Diseases, University of Torino, Italy.
Forno
B
B
Pollono
A M
AM
Busso
M
M
Arpinelli
F
F
Benedetti
M
M
Pugliese
A
A
D000704:Analysis of Variance; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007370:Interferon Type I / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis*; D009522:Newcastle disease virus / Q000276:immunology; D015242:Ofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000276:immunology; D013745:Tetanus Toxoid / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000276:immunology
D007370:Interferon Type I; D007376:Interleukin-2; D037102:Lectins; D008222:Lymphokines; D013745:Tetanus Toxoid; D007371:Interferon-gamma; D015242:Ofloxacin