Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition.
Thirty-four adults undergoing long-term parenteral nutrition (TPN) were treated either with or without intravenous taurine for less than or equal to 24 mo. Statistical comparisons were carried out in eight patients randomly assigned to receive intravenous taurine, usually 10 mg.kg-1.d-1, and 10 patients not receiving taurine. Compared with normal adults, baseline plasma taurine and urine taurine-creatinine ratios were decreased in both groups and platelet taurine was reduced in the taurine-treated group. During taurine treatment the mean of the mean values for taurine became normal in plasma and platelets and remained normal in erythrocytes, granulocytes, and lymphocytes; urine taurine-creatinine ratios rose to approximately five times normal. During follow-up, patients not given taurine had plasma, erythrocyte, and granulocyte taurine and urine taurine-creatinine ratios below normal values and the concentrations of taurine-treated patients. Their platelet taurine was also subnormal. Thus, 10 mg taurine.kg-1.d-1 intravenously normalizes plasma and blood cell taurine concentrations in long-term TPN patients.
Kopple
J D
JD
Department of Medicine, School of Medicine, UCLA, Torrance 90509.
Vinton
N E
NE
Laidlaw
S A
SA
Ament
M E
ME
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry; D003404:Creatinine / Q000652:urine; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006098:Granulocytes / Q000737:chemistry; D006801:Humans; D007262:Infusions, Intravenous; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D013654:Taurine / Q000097:blood / Q000494:pharmacology* / Q000652:urine
D013654:Taurine; D003404:Creatinine