title: Formulation and in vitro-in vivo evaluation of sustained-release lithium carbonate tablets.
abstract: The release of lithium carbonate incorporated into polymethylmethacrylate, polyvinyl chloride, hydrogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Ciftçi
authors.forename: Y
authors.initials: Y
authors.lastname: Capan
authors.forename: O
authors.initials: O
authors.lastname: Oztürk
authors.forename: A A
authors.initials: AA
authors.lastname: Hincal
mesh_terms: D000328:Adult; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000032:analysis; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D016651:Lithium Carbonate; D008094:Lithium