Identification of a single non-H-2 gene regulating graft-versus-host disease response.
Non-MHC loci have been shown to play an important role in the development and regulation of graft-vs-host disease (GVHD). In the murine model of GVHD under study, injection of C57BL/6 spleen cells into unirradiated (C57BL/6 x DBA/2)F1 hybrid recipient mice results in an acute form of GVHD characterized by CTL, suppressor cells, and runting. In contrast, injection of DBA/2 spleen cells into the same recipients results in a chronic form of GVHD that is characterized by a lack of CTL and hyperproduction of Ig and autoantibodies. After preliminary studies with the use of congenic mice showed that non-MHC loci were controlling GVHD responses in this model, genetic analysis of GVHD response of BXD recombinant inbred strains and (B10.D2 x DBA/2) X DBA/2 BC mice identified a single locus, Gvh, on chromosome 7 that controls whether acute or chronic GVHD results from injection of parental lymphocytes into unirradiated (C57BL/6 x DBA/2)F1 recipient mice.
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Department of Medicine, Rhode Island Hospital, Providence 02903.
D000818:Animals; D002874:Chromosome Mapping; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D006454:Hemoglobins / Q000235:genetics; D051379:Mice
D006183:H-2 Antigens; D006454:Hemoglobins