title: [The evolution of signal receptor proteins: conserved regions and the similarity to GTP-binding proteins].
abstract: A sequence comparison of signal receptor proteins (SR) was carried out using computer techniques based on physicochemical characteristics of amino acids. A new method of conserved regions determination for a family of proteins is described. Visual pigments have four, and all SR--three such regions in the cytoplasmic loops. Possible functional significance of these regions is discussed. We also report here that the family of SR is similar with the family of G-proteins involved in extracellular signal transduction. Both families have similar regions consisting of 7-8 amino acids and a number of identical amino acids distributed on the considerable part of the polypeptide chain of the proteins. These facts may indicate that the whole ensemble of the proteins participating in transmembrane signalling pathways (or some part of it) could evolve from a common progenitor. At the same time, similar structure elements of members of the mentioned protein families my be functionally important for protein-protein interaction.
authors.forename: D I
authors.initials: DI
authors.lastname: Frishman
authors.forename: A L
authors.initials: AL
authors.lastname: Berman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019204:GTP-Binding Proteins / Q000032:analysis*; D008433:Mathematics; D008969:Molecular Sequence Data; D011485:Protein Binding; D021382:Protein Sorting Signals / Q000032:analysis*; D015398:Signal Transduction
chemical_list: D021382:Protein Sorting Signals; D019204:GTP-Binding Proteins
vernacular_title: Evoliutsiia signal'nykh retseptornykh belkov: konservativnye uchastki i skhodstvo s GTF-sviazyvaiushchimi belkami.