title: [Cerebral malformation of the conceptus associated with maternal bacterial endocarditis and with aortic valve replacement during pregnancy].
abstract: A twenty-three years old woman, without previous heart disease developed endocarditis with negative bloods cultures on the fourth month of her third pregnancy. Fever was controlled through antibiotics, however she developed cardiac insufficiency and was submitted to surgery for replacement of aortic valve with a bioprosthesis. The post operative period showed no problems and the patient was discharged on the forty second day after admission. On the thirty ninth week of pregnancy she gave cesarean birth, without complications. The newly born, apgar 5 (1 min.) and 7 (5 min) presented signs of neurological problems, characterized on the second month as a cerebral atrophy. Among various possible factors, the most likely would be cardiopulmonary bypass circulation as the cause of the neurological malformation.
authors.affiliation: Instituto do Coração das Clínicas-FMUSP.
authors.forename: W S
authors.initials: WS
authors.lastname: Avila
authors.forename: M
authors.initials: M
authors.lastname: Grinberg
authors.forename: F
authors.initials: F
authors.lastname: Tarasoutchi
authors.forename: P
authors.initials: P
authors.lastname: Pomerantzeff
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
authors.forename: A
authors.initials: A
authors.lastname: Jatene
authors.forename: F
authors.initials: F
authors.lastname: Pileggi
mesh_terms: D000328:Adult; D001021:Aortic Valve; D001284:Atrophy / Q000209:etiology; D001921:Brain / Q000473:pathology*; D005314:Embryonic and Fetal Development; D004697:Endocarditis, Bacterial / Q000601:surgery*; D005260:Female; D005323:Fetal Monitoring; D006333:Heart Failure / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000601:surgery*
vernacular_title: Malformação cerebral do concepto associada à endocardite infecciosa materna e à substituição da valva aórtica durante a gestação.