title: Biological effect of interferon-gamma during the course of experimental infection of rat by Schistosoma mansoni.
abstract: We demonstrate here that a second mechanism of platelet activation dependent on lymphokine could also take place in the expression of platelet cytotoxicity against Schistosoma mansoni in vitro. Indeed, IgE, as previously described, but also IFN-gamma, present in the sera of infected rats, together induce platelets from normal rats into cytotoxic effectors for the parasitic larvae. This second mechanism appears also effective in vivo since the passive transfer of normal platelets treated by recombinant IFN-gamma (rIFN-gamma) and the administration of rIFN-gamma to rats conferred a protective immunity to S. mansoni.
authors.affiliation: Centre d'Immunologie et de Biologie Parasitaire, INSERM 167, Lille, France.
authors.forename: V
authors.initials: V
authors.lastname: Pancré
authors.forename: H
authors.initials: H
authors.lastname: Schellekens
authors.forename: P
authors.initials: P
authors.lastname: Van der Meide
authors.forename: H
authors.initials: H
authors.lastname: Vorng
authors.forename: A
authors.initials: A
authors.lastname: Delanoye
authors.forename: A
authors.initials: A
authors.lastname: Capron
authors.forename: C
authors.initials: C
authors.lastname: Auriault
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000503:physiopathology*
chemical_list: D011994:Recombinant Proteins; D007073:Immunoglobulin E; D007371:Interferon-gamma