title: L-threodops increases extracellular norepinephrine levels in the brain: an in vivo study.
abstract: Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.
authors.affiliation: Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: T
authors.initials: T
authors.lastname: Brannan
authors.forename: A
authors.initials: A
authors.lastname: Bhardwaj
authors.forename: M D
authors.initials: MD
authors.lastname: Yahr
mesh_terms: D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis*; D015103:Droxidopa / Q000494:pharmacology*; D005110:Extracellular Space / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000031:analogs & derivatives*
chemical_list: D012694:Serine; D015103:Droxidopa; D002230:Carbidopa; D009638:Norepinephrine