Towards an artificial cornea: surface modifications of optically clear, oxygen permeable soft contact lens materials by ammonia plasma modification technique for the enhanced attachment and growth of corneal epithelial cells.
The advent of high water content, oxygen permeable contact lens materials has made the intracorneal implants more feasible. A major obstacle encountered is the regrowth of a stable epithelium over the implant. Therefore, ammonia gaseous plasma modification technique was used to modify the surface chemical properties of soft contact lens material such as poly(2-hydroxyethyl methacrylate and methacrylic acid), PHEMA-MAA copolymer, in an attempt to enhance the cell attachment and growth of rabbit corneal epithelial cells.
Sipehia
R
R
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Garfinkle
A
A
Jackson
W B
WB
Chang
T M
TM
D000641:Ammonia; D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D003263:Contact Lenses, Hydrophilic; D003315:Cornea; D003432:Cross-Linking Reagents; D004848:Epithelium / Q000254:growth & development; D008422:Materials Testing; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; D019736:Prostheses and Implants; D014176:Protein Biosynthesis; D011817:Rabbits; D013499:Surface Properties
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; C059480:poly(hydroxyethyl methacrylate-methacrylic acid)hydrogel; D000641:Ammonia