Vascular mediation of gastric mucosal damage and cytoprotection.
This review addresses questions surrounding the role of the mucosal circulation in damage and protection against chemical injury to the stomach. The modern history of the topic is briefly summarized, and widely used methods are appraised critically. The role of the circulation is examined in mucosal injury and in cytoprotection, and a new conceptual model is described which involves the vasculature and inflammatory mediators.
Jacobson
E D
ED
Department of Medicine, School of Medicine, University of Colorado, Denver 80262.
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology*