title: Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
abstract: A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.
authors.affiliation: Department of Biochemistry, New York University School of Medicine, New York 10016.
authors.forename: G T
authors.initials: GT
authors.lastname: Drivas
authors.forename: A
authors.initials: A
authors.lastname: Shih
authors.forename: E
authors.initials: E
authors.lastname: Coutavas
authors.forename: M G
authors.initials: MG
authors.lastname: Rush
authors.forename: P
authors.initials: P
authors.lastname: D'Eustachio
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D019204:GTP-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D015723:Gene Library; D011905:Genes, ras; D006801:Humans; D007256:Information Systems; D008969:Molecular Sequence Data; D005810:Multigene Family; D015345:Oligonucleotide Probes; D012689:Sequence Homology, Nucleic Acid; D013724:Teratoma / Q000235:genetics*
chemical_list: D015345:Oligonucleotide Probes; D019204:GTP-Binding Proteins