title: Hepatic fibrosis: new insights into pathogenesis.
abstract: From available clinical and experimental data, the deterioration of hepatocellular function associated with fibrosis may be ascribed, in part, to loss of biologic support provided by a normal extracellular matrix. These studies of pathogenesis are expected to clarify new points of therapeutic intervention and also to rationalize empiric therapies.
authors.affiliation: University of California, San Francisco, School of Medicine.
authors.forename: S L
authors.initials: SL
authors.lastname: Friedman
authors.forename: D M
authors.initials: DM
authors.lastname: Bissell
mesh_terms: D001485:Basement Membrane / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000166:cytology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000209:etiology* / Q000503:physiopathology