Pattern of relapses in sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys.
The pattern of sequential relapses in 10 rhesus monkeys following inoculation of sporozoites of Plasmodium cynomolgi B has been studied after administering curative dose of chloroquine (5 mg/kg base X 7 days) to eliminate blood parasitaemia after each relapse. Observation for periods ranging from 109 to 245 days showed that the interval between first six relapses was 19.3 +/- 6.77 days (1st relapse), 20.9 +/- 8.43 days (2nd relapse), 22.8 +/- 8.55 days (3rd relapse), 27.8 +/- 10.0 days (4th relapse), 31.67 +/- 11.50 days (5th relapse) and 32.5 +/- 16.26 days (6th relapse). The results of this study indicate a gradual extension of the relapse interval in successive relapses.
Puri
S K
SK
Sharma
P
P
Dutta
G P
GP
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D012008:Recurrence; D013997:Time Factors
D002738:Chloroquine