title: Reactivity toward cysteine of antimicrobial carbamimidothioic acid phenylalkylesters salts.
abstract: The rates of reaction toward cysteine of a series of carbamimidothioic acid phenylmethylesters halides were investigated in phosphate buffer pH 7.4 at 37 degrees C under pseudo-first-order conditions. The reaction involves nucleophilic attack of cysteine on the C-S bond of isothiouronium mojety and corresponding benzenemethanethiols were detected as product of the reaction. Apparent first-order rate constants were determined.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tait
authors.forename: M
authors.initials: M
authors.lastname: Di Bella
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D013859:Thiocarbamates; D003545:Cysteine