title: Third place--Resident Clinical Science Award 1990. The in vivo and in vitro effect of phenylephrine (Neo Synephrine) on nasal ciliary beat frequency and mucociliary transport.
abstract: Twenty volunteers with normal noses were studied to determine the effect of phenylephrine on nasal ciliary function. In vivo study of this drug was performed in 15 patients and revealed a significant increase in their ciliary beat frequency from a control of 11 Hz to 12.03 Hz (p = 0.001). Mucociliary transit times in these volunteers were also studied, revealing a mean of 9.9 minutes prestimulation and 10.2 minutes poststimulation, which was not statistically significant (p = 0.77). Five additional subjects donated ciliated mucosal samples for in vitro analysis of varying concentrations of this agent that showed a significant ciliostimulatory effect at lower concentrations (0.01%), with a progressive cilioinhibitory effect at higher concentrations (0.25%, 0.5%). The 0.05% concentration showed no significant change in ciliary activity compared to control measurements. These data demonstrate that phenylephrine has a ciliostimulatory effect in vivo, as well as in appropriate concentrations in vitro, and should be safe and relatively nontoxic to the mucociliary apparatus for short-term use.
authors.affiliation: Department of Otolaryngology, Mayo Clinic-Rochester, MN 55901.
authors.forename: P P
authors.initials: PP
authors.lastname: Phillips
authors.forename: T V
authors.initials: TV
authors.lastname: McCaffrey
authors.forename: E B
authors.initials: EB
authors.lastname: Kern
mesh_terms: D001363:Awards and Prizes; D002478:Cells, Cultured; D002923:Cilia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects*; D009666:Nose / Q000187:drug effects*; D010036:Otolaryngology; D010656:Phenylephrine / Q000494:pharmacology*; D012016:Reference Values; D014481:United States
chemical_list: D010656:Phenylephrine