[Cryptococcosis in AIDS: therapeutic concepts].
Cryptococcosis is the most common life-threatening mycosis with AIDS. The combination therapy based on amphotericin B and flucytosine is furthermore the therapy of first choice, even after introduction of fluconazole. With a therapy maintained over a period of 6 weeks the combination is nearly always successful; a shorter treatment period leads to minor treatment success. Since no elimination of the pathogen is possible in cryptococcosis with AIDS a permanent relapse prevention is necessary. In this prevention strategy fluconazole is highly effective and at present the drug of first choice; it is as effective as amphotericin B. An additional advantage is the possibility of oral application.
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II. Medizinische Klinik, Klinikums Rudolf Virchow (Wedding), Freien Universität Berlin.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000666:Amphotericin B / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000627:therapeutic use*; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans
D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine
Cryptococcose bei AIDS: Therapeutische Konzepte.