title: In vitro activity of cefpirome compared with other third generation cephalosporins against nosocomial isolates in Argentina.
abstract: The in vitro activity of cefpirome was evaluated against strains that showed conflicting results for third generation cephalosporins. Against isolates with derepressed inducible chromosomal cephalosporinase (n = 40) cefpirome was the sole cephalosporin with an MIC90 in the susceptible range; Klebsiella spp. with plasmid-mediated beta-lactamases (broad spectrum SHV-2 or SHV-2 type) (n = 40) remained most susceptible to ceftizoxime and cefpirome; against aminoglycoside-resistant Pseudomonas aeruginosa (n = 50), cefpirome was as active as ceftazidime and cefoperazone; against oxacillin-susceptible and oxacillin-resistant Staphylococcus spp., (n = 40), cefpirome was more active than other third generation cephalosporins but killing was inadequate against both oxacillin-resistant staphylococci and enterococci.
authors.affiliation: Department of Infectious Diseases and Microbiology, Universidad Católica, Buenos Aires, Argentina.
authors.forename: J M
authors.initials: JM
authors.lastname: Casellas
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: N
authors.initials: N
authors.lastname: Orellana
authors.forename: M I
authors.initials: MI
authors.lastname: Morosini
authors.forename: M C
authors.initials: MC
authors.lastname: Negri
authors.forename: S
authors.initials: S
authors.lastname: Arduino
mesh_terms: D001118:Argentina; D001419:Bacteria / Q000187:drug effects*; D002510:Cephalosporinase / Q000032:analysis; D002511:Cephalosporins / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D000097572:Cefpirome
chemical_list: D002510:Cephalosporinase; D002511:Cephalosporins; D000097572:Cefpirome