Effect of tamoxifen and kallikrein on sperm parameters including hypoosmotic swelling test in subfertile males. A retrospective analysis.
151 subfertile men presenting OAT-syndrome were investigated in respect of an improvement of sperm parameters under therapy with tamoxifen, kallikrein and combined treatment of both drugs. After therapy with 30 mg tamoxifen per day (75 patients), a significant elevation of density and swelling test was seen. Medication with 600 IE kallikrein per day (36 patients) revealed only a slight improvement of motility. Also combined treatment of 30 mg tamoxifen with 600 IE kallikrein per day produced only an elevation of motility without any significant change of other sperm parameters.
Höbarth
K
K
Department of Urology, University of Vienna, Medical School, Austria.
Lunglmayr
G
G
Kratzik
C
C
D004359:Drug Therapy, Combination; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000503:physiopathology*; D007610:Kallikreins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009845:Oligospermia / Q000188:drug therapy / Q000503:physiopathology*; D009994:Osmolar Concentration; D012189:Retrospective Studies; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013577:Syndrome; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D013629:Tamoxifen; D007610:Kallikreins