title: Removal of immunosuppressive substance in cancer patients' serum.
abstract: Anemia-inducing substance (AIS) appears in plasma as cancer progresses. In this study, a non-coated charcoal column was used to remove AIS from the cachectic plasma obtained from patients with advanced cancer. AIS could be completely removed by 6 cycles of adsorption using this column. Similar data were obtained in an experiment using VX-2-transplanted rabbits. These observations raised the possibility that plasmapheresis with a non-coated charcoal column may be available as a new means of immunotherapy for advanced cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School.
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: M
authors.initials: M
authors.lastname: Deguchi
authors.forename: I
authors.initials: I
authors.lastname: Tatsuta
authors.forename: K
authors.initials: K
authors.lastname: Naka
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Nakata
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Sugawa
mesh_terms: D001685:Biological Factors / Q000302:isolation & purification*; D001798:Blood Proteins / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000628:therapy; D002606:Charcoal; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007167:Immunotherapy; D010051:Ovarian Neoplasms / Q000150:complications / Q000276:immunology* / Q000628:therapy; D010956:Plasmapheresis
chemical_list: D001685:Biological Factors; D001798:Blood Proteins; D002606:Charcoal