title: Postnatal development of the glycine cleavage system in rat liver.
abstract: The development of the glycine cleavage system was studied in liver mitochondrial extracts from neonatal and adult rats. The enzyme activity in 2-day-old pups was 29.3% of that measured in the adult and was found to increase in an age-dependent manner. Measurement of hepatic free amino acid concentrations at the neonatal ages showed that glycine levels were highest at 2 days and at 14 days were about 48% of those in the 2-day-old pups. Serine levels did not change between the age of 2 and 14 days. A developmental delay in the glycine cleavage system is responsible for the high levels of glycine in the neonatal rat liver.
authors.affiliation: Nassau County Medical Center, Department of Pediatrics, State University of New York, East Meadow 11554.
authors.forename: S S
authors.initials: SS
authors.lastname: Kalbag
authors.forename: A G
authors.initials: AG
authors.lastname: Palekar
mesh_terms: D000375:Aging / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D050960:Aminomethyltransferase; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005260:Female; D005998:Glycine / Q000378:metabolism*; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism; D019877:Hydroxymethyl and Formyl Transferases; D008099:Liver / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D012694:Serine; D014166:Transferases; D019877:Hydroxymethyl and Formyl Transferases; D012696:Glycine Hydroxymethyltransferase; D050960:Aminomethyltransferase; D005998:Glycine