Listericidal activity of human neutrophil cathepsin G.
We demonstrate that cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule. The listericidal activity of cathepsin G occurred in a manner that was both time-dependent and concentration-dependent.
Alford
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Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
Amaral
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Campbell
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PA
D056649:Cathepsin G; D002403:Cathepsins / Q000494:pharmacology*; D002412:Cations; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008089:Listeria monocytogenes / Q000187:drug effects*; D009504:Neutrophils / Q000201:enzymology*; D012697:Serine Endopeptidases
D002412:Cations; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G