Interleukin-2 inhibits growth of fibroblasts derived from human bone marrow.
The adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells (CFU-F). We have demonstrated that recombinant interleukin-2 (r-IL2) inhibits growth of CFU-F by preventing their entry into S phase. This inhibition is not mediated by gamma-interferon, nor by T lymphocytes, and can be abrogated by anti-IL2 receptor antibody. r-IL2 may influence haematopoiesis by its effect on bone marrow CFU-F.
MacDonald
D
D
Department of Haematology, Westminster Hospital, London, UK.
Adams
J A
JA
McCarthy
D
D
Barrett
A J
AJ
D001685:Biological Factors / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003114:Colony-Forming Units Assay; D016207:Cytokines; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D001685:Biological Factors; D016207:Cytokines; D007376:Interleukin-2; D011994:Recombinant Proteins