Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.
The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.
Yamaguchi-Iwai
Y
Y
Department of Viral Oncology, Kyoto University, Japan.
Satake
M
M
Murakami
Y
Y
Sakai
M
M
Muramatsu
M
M
Ito
Y
Y
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics*; D011905:Genes, ras; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D013724:Teratoma; D014157:Transcription Factors / Q000235:genetics*; D014162:Transfection
D004268:DNA-Binding Proteins; D016755:Proto-Oncogene Proteins c-jun; D012334:RNA, Neoplasm; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases