[Enzymatic induction with phenobarbital and 3-methylcholanthrene in rats exposed to normobaric oxygen].
Induction by phenobarbital and 3-methylcholanthrene of enzymes metabolizing xenobiotics in rat exposed 55 hrs to hyperoxia, is maintained. The level of microsomal pulmonary and hepatic cytochrome P-450 has even increased. In rat protected against a hyperoxia 6 days, stimulation of UDP-glucuronosyltransferase does not decrease and malondialdehydes level does not change. These results assume the probable role of enzymatic induction in the tolerance to hyperoxia induced in rast by treatment with phenobarbital and 3- methylcholanthrene.
Nasraoui
A
A
Institut National de Nutrition de Tunis, Bab Saâdoun.
Pocidalo
J J
JJ
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D005609:Free Radicals; D008107:Liver Diseases / Q000188:drug therapy* / Q000201:enzymology; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D008748:Methylcholanthrene / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010100:Oxygen / Q000506:poisoning*; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011041:Poisoning / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen; D010634:Phenobarbital
Induction enzymatique par le phénobarbital et par le 3-méthylcholanthrène chez le rat exposé à l'oxygène normobare.