Myoplasmic phosphate metabolites in the integration of oxidative phosphorylation and contractile function in the myocardium.
The role of cytosolic concentrations of ADP, ATP, phosphocreatine, and Pi in the regulation of energy turnover in the myocardium has been investigated. For this purpose pool sizes of cytosolic adenine nucleotides or total creatine were significantly reduced, and creatine kinase activity completely inhibited. The findings show that the cytosolic ADP, the [ATP]/[ADP] ratio, and the phosphorylation potential are not uniformly related to the intensity of contractile function and the oxidative phosphorylation rate. Other mechanisms of coordination of these processes have to be taken into account.
Kupriyanov
V V
VV
Institute of Experimental Cardiology, Academy of Medical Sciences of the USSR, Moscow.
Lakomkin
V L
VL
Kapelko
V I
VI
Saks
V A
VA
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008928:Mitochondria / Q000201:enzymology; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates; D003402:Creatine Kinase; D007545:Isoproterenol