Relevance of vascular PGI2 synthase to vascular prostacyclin production in Dahl rats susceptible to salt-induced hypertension.
To assess the roles of prostacyclin (PGI2) synthase in vascular PGI2 generation, the enzymatic activity was examined in the mesenteric artery of Dahl S rats in the prehypertensive or hypertensive stage. Elevation of blood pressure in Dahl S rats was accompanied by an increase of vascular PGI2 synthase activity. The enzymatic activity was positively correlated to the blood pressure value. Similarly, impaired vascular capacity to generate PGI2, which was observed in prehypertensive Dahl S rats, was restored to the control level of Dahl R rats with the elevation of blood pressure. These data indicate that vascular PGI2 synthase activity is increased with blood pressure elevation, thereby contributing to the restoration of vascular capacity to generate PGI2 in Dahl S rats.
Uehara
Y
Y
Second Department of Internal Medicine, University of Tokyo, Japan.
Ishimitsu
T
T
Iwai
J
J
Ishii
M
M
Sugimoto
T
T
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001808:Blood Vessels / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism / Q000502:physiology*; D004198:Disease Susceptibility; D011464:Epoprostenol / Q000096:biosynthesis*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D019746:Intramolecular Oxidoreductases; D007535:Isomerases / Q000378:metabolism / Q000502:physiology*; D008638:Mesenteric Arteries / Q000201:enzymology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D012965:Sodium Chloride; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D007535:Isomerases; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase