A comparison of 131I-labeled antibodies, 2-deoxy-2-[18F]fluoro-D-glucose and 68Ga-EDTA in the imaging of human tumor xenografts in nude mice.
Three different biological properties--glucose metabolism, gallium imaging and antigen-antibody interaction--have been targeted to image human tumor xenografts implanted in nude mice. Seventy-two experiments were performed in 25 nude mice. Two types of human tumors were used: colorectal carcinoma SW 1116 and melanoma WM 9. Immunoscintigraphic studies produced the highest tumor sampling and confirmed earlier findings that F(ab')2 fragments generate better tumor images than whole antibodies.
Brownell
A L
AL
University Central Hospital of Helsinki, Meilahti Hospital, Laboratory Department, Finland.
Karonen
S L
SL
Korpela
H
H
Lindroth
L
L
Aaltonen
J
J
Nikkinen
P
P
Lindgren
J
J
D000818:Animals; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000276:immunology; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D003837:Deoxy Sugars; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004492:Edetic Acid; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D006801:Humans; D007457:Iodine Radioisotopes; D008545:Melanoma / Q000000981:diagnostic imaging*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D003837:Deoxy Sugars; D005462:Fluorine Radioisotopes; D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D004492:Edetic Acid