Serum carbonic anhydrase III and myoglobin concentrations in acute myocardial infarction.
Serum concentrations of myoglobin (S-Myo) and carbonic anhydrase III (S-CA III; EC 4.2.1.1), a skeletal muscle-specific protein, were measured by RIA in 26 patients with acute myocardial infarction, 14 patients with neuromuscular diseases, and six healthy subjects before and after physical exercise. S-Myo was increased in infarct patients, whereas S-CA III was not altered. In patients with neuromuscular diseases and in healthy subjects after physical exercise, both S-Myo and S-CA III were significantly increased. S-CA III and S-Myo also showed identical peak times, 2 h postexercise. The S-Myo/S-CA III ratio was always higher in infarct patients than in the other groups. Thus, the combination of S-CA III and S-Myo determinations is useful to differentiate whether serum myoglobin is originating from myocardium or from skeletal muscle.
Väänänen
H K
HK
Department of Anatomy, University of Oulu, Finland.
Syrjälä
H
H
Rahkila
P
P
Vuori
J
J
Melamies
L M
LM
Myllylä
V
V
Takala
T E
TE
D000328:Adult; D002256:Carbonic Anhydrases / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology*; D009211:Myoglobin / Q000097:blood*; D009468:Neuromuscular Diseases / Q000201:enzymology; D011863:Radioimmunoassay
D009211:Myoglobin; D003402:Creatine Kinase; D002256:Carbonic Anhydrases