Recurrent medulloblastoma: frequency of tumor enhancement on Gd-DTPA MR imaging.
Thirty-two children with medulloblastoma were evaluated postoperatively with conventional and gadolinium-enhanced MR imaging. Eleven patients had abnormal cranial MR studies; nine of these had recurrent tumor. In six patients recurrent tumor enhanced with Gd, while in the other three patients recurrent tumor did not enhance. The remaining two patients had areas of abnormal Gd enhancement that were caused by radiation-induced breakdown of the blood-brain barrier rather than by recurrent tumor. This study shows that not all recurrent medulloblastoma enhances and that the absence of Gd enhancement does not necessarily indicate the absence of recurrent tumor.
Rollins
N
N
Department of Radiology, Children's Medical Center, Dallas, TX 75235.
Mendelsohn
D
D
Mulne
A
A
Barton
R
R
Diehl
J
J
Reyes
N
N
Sklar
F
F
D000293:Adolescent; D001812:Blood-Brain Barrier / Q000528:radiation effects; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D009942:Organometallic Compounds; D004369:Pentetic Acid
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA