[Treatment of acute hepatic encephalopathy with flumazenil].
In animal studies as well as in a few cases in humans, the benzodiazepine antagonist flumazenil has been shown to reverse hepatic encephalopathy. The authors treated 3 patients with acute hepatic encephalopathy stage III or IV complicating cirrhosis. Two patients had an immediate recovery, maintained with a continuous infusion of flumazenil. In the third patient the clinical status dit not improve but the hepatic encephalopathy coexisted with major abnormalities in blood gases and electrolytes abnormalities, which could participate to the neurologic failure.
Viel
E
E
Département d'Anesthésie-Réanimation, Centre Hospitalier Régional et Universitaire, Nîmes.
de La Coussaye
J E
JE
Bassoul
B
B
Saissi
G
G
Eledjam
J J
JJ
D000208:Acute Disease; D005442:Flumazenil / Q000008:administration & dosage / Q000627:therapeutic use*; D015600:Glasgow Coma Scale; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged
D005442:Flumazenil
Traitement de l'encéphalopathie hépatique aiguë par le flumazénil.