[Production of human proteins in the blood of transgenic animals].
The human alpha 1-antitrypsin gene has been microinjected into rabbit embryos. A line of transgenic rabbits has thus been established. Human alpha 1-antitrypsin was found in the blood of transgenic animals at the concentration of 1 mg/ml plasma. The human protein was active and separable from its rabbit counterpart. This experiment demonstrates that it is possible to use blood from transgenic animals as a source of recombinant proteins.
Massoud
M
M
Institut national de la Recherche agronomique, Jouy-en-Josas.
Bischoff
R
R
Dalemans
W
W
Pointu
H
H
Attal
J
J
Schultz
H
H
Clesse
D
D
Stinnakre
M G
MG
Pavirani
A
A
Houdebine
L M
LM
D000818:Animals; D030801:Animals, Genetically Modified / Q000097:blood*; D005260:Female; D005796:Genes / Q000235:genetics; D006801:Humans; D008297:Male; D011817:Rabbits; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
D000515:alpha 1-Antitrypsin
La production de protéines humaines dans le sang d'animaux transgéniques.