[Transient reduction of ventricular tachycardia with adenosine-5'-triphosphate. A possible action of ATP on purinergic receptors].
The authors report the case of a 46 year old man in whom a regular, wide complex tachycardia was terminated temporarily by the injection of adenosine-5'-triphosphate (ATP:Striadyne); endocavitary electrophysiological studies showed the tachycardia to be of ventricular origin. After aminophylline, an inhibitor of certain purinergic receptors, the tachycardia could be reproduced at will and was sustained whereas only short runs of tachycardia could be induced under basal conditions. The mode of action of the ATP on this type of tachycardia could be a direct effect of the molecule on the purinergic receptors specifically inhibited by aminophylline.
Scanu
P
P
Service de soins intensifs cardiologiques, hôpital Côte de Nacre, CHU de Caen.
Grollier
G
G
Dorey
H
H
Gofard
M
M
Bonnet
H
H
Guilleman
D
D
Besson
C
C
Potier
J C
JC
D000255:Adenosine Triphosphate / Q000494:pharmacology / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011983:Receptors, Purinergic / Q000187:drug effects; D013610:Tachycardia / Q000188:drug therapy*
D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate
Réduction transitoire d'une tachycardie ventriculaire par l'adénosine-5'-triphosphate. Action possible de l'ATP sur les récepteurs purinergiques.