title: Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.
abstract: Eighty-nine patients with uncomplicated gonorrhea, including 31 patients (34.8%) infected with penicillinase-producing strains of Neisseria gonorrhoeae, were treated with oral ofloxacin (single 400-mg dose) or intramuscular ceftriaxone (250-mg dose). All 47 patients who received ofloxacin and 41 of 42 patients who received ceftriaxone were cured.
authors.affiliation: Department of Medicine, State University of New York Health Science Center, Brooklyn.
authors.forename: J M
authors.initials: JM
authors.lastname: Covino
authors.forename: M
authors.initials: M
authors.lastname: Cummings
authors.forename: B
authors.initials: B
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Benes
authors.forename: K
authors.initials: K
authors.lastname: Draft
authors.forename: W M
authors.initials: WM
authors.lastname: McCormack
mesh_terms: D000328:Adult; D002443:Ceftriaxone / Q000627:therapeutic use*; D002692:Chlamydia trachomatis / Q000187:drug effects; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology*; D015242:Ofloxacin / Q000627:therapeutic use*; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*
chemical_list: D002443:Ceftriaxone; D015242:Ofloxacin; D010405:Penicillinase