title: [Determination of anti-mycobacteria antibody titers by ELISA for the early diagnosis of tuberculosis].
abstract: Determination of anti-mycobacteria antibody titers by ELISA for the early diagnosis of tuberculosis was critically reviewed from methodological point of view. Especially, the method of data-handling to calculate the antibody titers from optical density values obtained by ELISA and also the method to evaluate the clinical usefulness of this test were reassessed. Determination of anti-mycobacteria antibody titer by ELISA is highly sensitive and satisfactorily specific, and far more useful than, or at least as useful as, various on-going methods for the early diagnosis of pulmonary as well as extra-pulmonary tuberculosis. This test should be included in a routine examination system for the diagnosis of tuberculosis in the clinical laboratories.
authors.affiliation: Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose.
authors.forename: I
authors.initials: I
authors.lastname: Toida
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial