title: A non-invasive method for fractionated stereotactic irradiation of brain tumors with linear accelerator.
abstract: A new technique for fractionated stereotactic irradiation of intracranial lesions is described. The treatment is based on a versatile, non-invasive interface for stereotactic localization of the brain target imaged by computed tomography (CT), angiography or magnetic resonance tomography (MRT), and subsequent repetitive stereotactic irradiation of the target using a linear accelerator. The fractionation of the stereotactic irradiation was intended to meet the requirements of the basic principles of radiobiology. The radiophysical evaluation using phantoms, and the clinical results in a small number of patients, demonstrated a good reproducibility between repeated positionings of the target in the isocenter of the accelerator, and a high degree of accuracy in the treatment of brain lesions.
authors.affiliation: Department of Neurosurgery, University Hospital, Umeå, Sweden.
authors.forename: M I
authors.initials: MI
authors.lastname: Hariz
authors.forename: R
authors.initials: R
authors.lastname: Henriksson
authors.forename: P O
authors.initials: PO
authors.lastname: Löfroth
authors.forename: L V
authors.initials: LV
authors.lastname: Laitinen
authors.forename: N E
authors.initials: NE
authors.lastname: Säterborg
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011882:Radiotherapy, High-Energy / Q000379:methods*; D013238:Stereotaxic Techniques / Q000295:instrumentation / Q000592:standards; D014057:Tomography, X-Ray Computed