Effect of parenteral oestrogen on the coagulation system in patients with prostatic carcinoma.
Patients with prostatic carcinoma on oral oestrogen therapy have an altered coagulation system and suffer cardiovascular side effects. Oestrogens--especially oral oestrogens--are potent inducers of liver synthesised proteins, including coagulation factors. We have assessed the effect of non-oral oestrogen on the coagulation system in patients with prostatic carcinoma. Twelve patients were given monthly intramuscular injections of 320 mg polyoestradiol phosphate (PEP). No additional oestrogens were given. No change was found in any of the coagulation factors, including factor VII, with the exception of a significant decrease in antithrombin III. No patient, including 38 patients treated with PEP, had any cardiovascular complications after a mean follow-up period of 12.9 +/- 0.7 months; 76% of the patients responded to treatment. Parenteral administration of oestrogen caused a less marked change in the coagulation system than oral administration and should be the treatment of choice for prostatic carcinoma.
Henriksson
P
P
Department of Medicine, Huddinge Hospital, Sweden.
Blombäck
M
M
Eriksson
A
A
Stege
R
R
Carlström
K
K
D000990:Antithrombin III / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis; D003174:Complement C1 Inactivator Proteins; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000008:administration & dosage* / Q000627:therapeutic use; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010958:Plasminogen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*
D001779:Blood Coagulation Factors; D001798:Blood Proteins; D003174:Complement C1 Inactivator Proteins; D045166:Estradiol Congeners; C031220:urokinase inhibitor; D004958:Estradiol; D000990:Antithrombin III; D005167:Factor VII; D005169:Factor VIII; D005340:Fibrinogen; D010958:Plasminogen; C008958:polyestradiol phosphate