title: Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferon-gamma in Lewis rats.
abstract: Experimental allergic encephalomyelitis (EAE) is an autoimmune inflammatory disease of the central nervous system (CNS) which causes paralysis. Several studies have reported the involvement of Ia antigen-expressing cells in the pathogenesis of EAE. Interferon-gamma (IFN-gamma) can induce Ia antigen expression on a wide range of cells. We examined the effect of IFN-gamma on EAE in Lewis rats. Systemically administered IFN-gamma did not change the disease course of EAE, whereas IFN-gamma applied locally into the ventricular system of the CNS resulted in complete suppression of clinical signs. Furthermore, we found that systemic administration of anti-IFN-gamma just prior to the onset of clinical symptoms resulted in a more severe disease course. We conclude that IFN-gamma is capable of exerting a suppressive action in EAE, possibly through induction of Ia antigen expression or through the induction of suppressive mechanisms locally in the CNS.
authors.affiliation: Department of Cell Biology, Free University, Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Voorthuis
authors.forename: B M
authors.initials: BM
authors.lastname: Uitdehaag
authors.forename: C J
authors.initials: CJ
authors.lastname: De Groot
authors.forename: P H
authors.initials: PH
authors.lastname: Goede
authors.forename: P H
authors.initials: PH
authors.lastname: van der Meide
authors.forename: C D
authors.initials: CD
authors.lastname: Dijkstra
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D002531:Cerebellum / Q000276:immunology / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D007124:Immunoenzyme Techniques; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007371:Interferon-gamma / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D008297:Male; D009900:Optic Nerve / Q000276:immunology / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D011994:Recombinant Proteins; D007371:Interferon-gamma