The effects of zinc on the alveolar macrophage cytotoxicity due to Ni-coal dust.
The possibility of the combined effects on the alveolar macrophage cytotoxicity due to zinc and Ni-coal dust was studied. The parameters in the experiments were cellular ATP level in alveolar macrophage (AM), cellular K+ and Zn++ in AM and the surface morphological changes of AM. The experimental results showed that low zinc can protect the toxicity of Ni-coal dust on AM, and that the protective effects on the toxicity of Ni-coal dust by zinc are dependent on its dosage. The ATP level and K+ content in AM are sensitive indices in reflecting the cytotoxicity and can be used in detecting environmental toxic substances.
Wu
X F
XF
Institute of Industrial Health and Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou.
Zhang
Q F
QF
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003031:Coal; D004391:Dust / Q000009:adverse effects; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009532:Nickel / Q000633:toxicity*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000494:pharmacology*
D003031:Coal; D004391:Dust; D009532:Nickel; D000255:Adenosine Triphosphate; D015032:Zinc; D011188:Potassium