title: Distribution of angiotensin II receptors in the brain of nonhuman primates.
abstract: Angiotensin II binding sites were demonstrated at discrete nuclei in the brain of three nonhuman primate species by autoradiography, using the agonist ligand, [Sar1]AII. Although there were some differences in location of the binding sites, all three species exhibited a characteristic pattern of distribution in areas related to water intake, vasopressin secretion, and blood pressure regulation through modulation of sympathetic activity. Studies in the cynomolgus monkey with the antagonist ligand, [Sar1,Ile8]AII, which localizes in pathways as well as nuclei, revealed novel regions of binding including the habenular-interpeduncular pathway, ventral bundle, and XII nerve, in addition to the X nerve. These data indicated that AII, as in other species, has a role in the central homeostatic control mechanisms in the primate.
authors.affiliation: Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD 20892.
authors.forename: M A
authors.initials: MA
authors.lastname: Millan
authors.forename: D M
authors.initials: DM
authors.lastname: Jacobowitz
authors.forename: K J
authors.initials: KJ
authors.lastname: Catt
authors.forename: G
authors.initials: G
authors.lastname: Aguilera
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D002143:Callitrichinae; D008252:Macaca fascicularis; D008566:Membranes / Q000032:analysis; D011945:Receptors, Angiotensin / Q000032:analysis* / Q000378:metabolism; D012453:Saimiri
chemical_list: D011945:Receptors, Angiotensin; D000804:Angiotensin II