[Vasomotility of the bronchial circulation in cardiac failure].
The bronchial circulation is a physiological left-to-left shunt; the venous return of the bronchial arteries vascularising the intra-pulmonary bronchi drains directly into the left heart chambers. In cardiac failure, increased left ventricular filling pressures affects the bronchial circulation and causes stasis and congestion. Congestion of the arterial and venous bronchial microcirculation leads to thickening of the bronchial mucosa and submucosa, resulting in a tendency to obstruct small and medium-sized airways. The bronchial circulation can be explored indirectly in cardiac failure by the spirometric response to adrenergic agonists and antagonists administered by inhalation: bronchial vasomotor phenomena explain the symptomatology of cardiac asthma and also seem to play a role in the genesis of the dyspnoea of effort in patients with cardiac failure.
Cabanes
L
L
Service de cardiologie et d'exploration fonctionnelle, hôpital Cochin, Paris, France.
Weber
S
S
Lockhart
A
A
Guerin
F
F
D001980:Bronchi / Q000098:blood supply* / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000037:antagonists & inhibitors; D008729:Methoxamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology*
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D008729:Methoxamine; D010646:Phentolamine
Vasomotricité de la circulation bronchique dans l'insuffisance cardiaque.