title: Clinical results with subcutaneous implants containing 3-keto desogestrel.
abstract: Eight healthy women using one Silastic implant of 30 mm length filled with 3-keto desogestrel, the active metabolite of desogestrel, were studied for 36-664 days. The release rate of 3-keto desogestrel was quite constant and around 30 micrograms/day. No ovulations occurred. One woman was amenorrheic, while the others had different bleeding patterns, often with periods of spotting. No other side effects were recorded. The mean plasma levels of 3-keto desogestrel were 0.9 nmol/l after 1 month and 0.5 nmol/l after 12 months. 3-Keto desogestrel was less effective than testosterone, estradiol or levonorgestrel in displacing 3H-dihydrotestosterone from SHBG. It is concluded that contraception with 3-keto desogestrel delivered through an implant is a promising method for further investigation. With a single implant we found a duration of at least one year.
authors.affiliation: Department of Obstetrics and Gynecology, University of Uppsala, Sweden.
authors.forename: S E
authors.initials: SE
authors.lastname: Olsson
authors.forename: V
authors.initials: V
authors.lastname: Odlind
authors.forename: E
authors.initials: E
authors.lastname: Johansson
mesh_terms: D001667:Binding, Competitive; D003277:Contraceptives, Oral, Combined; D017135:Desogestrel; D013196:Dihydrotestosterone / Q000378:metabolism; D004343:Drug Implants; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008598:Menstruation / Q000187:drug effects*; D009644:Norgestrel / Q000378:metabolism; D009652:Norpregnenes / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
chemical_list: D003277:Contraceptives, Oral, Combined; D004343:Drug Implants; D009652:Norpregnenes; D045167:Progesterone Congeners; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; C044815:etonogestrel; D009644:Norgestrel; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D016912:Levonorgestrel; D017135:Desogestrel