The effect of antidepressants on aversive periaqueductal gray stimulation in rats.
The selective serotonin (5-HT) uptake inhibitors fluvoxamine and sertraline had anti-aversive effects when administered acutely. Imipramine and clomipramine, which combine noradrenaline (NA) and 5-HT uptake blocking properties, did not have significant effects, whereas the mixed dopamine (DA)/NA uptake blocker nomifensine decreased the thresholds for escape from aversive periaqueductal gray stimulation. These results suggest that indirect 5-HT receptor activation suppresses periaqueductal gray aversion. Conversely, indirect DA and perhaps NA receptor activation appears to enhance periaqueductal gray aversion in rats.
Jenck
F
F
CNS Pharmacology Department, ORGANON International, Oss, The Netherlands.
Broekkamp
C L
CL
Van Delft
A M
AM
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D016666:Fluvoxamine; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009627:Nomifensine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010091:Oximes / Q000494:pharmacology; D010487:Periaqueductal Gray / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000378:metabolism; D020280:Sertraline
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D010091:Oximes; D009627:Nomifensine; D012701:Serotonin; D015057:1-Naphthylamine; D016666:Fluvoxamine; D007099:Imipramine; D020280:Sertraline; D004298:Dopamine; D009638:Norepinephrine