Effect of aspartate and glutamate on carbon tetrachloride induced liver damage in rats.
Liver necrosis was produced in rats by administering 3 doses of a mixture of carbon tetrachloride + olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aspartate and glutamate administration (100 mg/kg, ip) significantly reduced these elevated levels of AST, ALT, and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in aspartate and glutamate pretreated animals as observed macroscopically and histologically.
Singh
J
J
Department of Pharmacology and Pathology, Medical College, Rohtak, India.
Garg
K N
KN
Mehrotra
G C
GC
D000818:Animals; D001224:Aspartic Acid / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors; D056486:Chemical and Drug Induced Liver Injury; D005971:Glutamates / Q000627:therapeutic use*; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D001224:Aspartic Acid; D002251:Carbon Tetrachloride