title: The effect of ofloxacin on the immune system of elderly patients.
abstract: In twenty elderly patients with infectious diseases, some immune parameters were evaluated before and after treatment with ofloxacin. Results showed that the number of T cells, B cells, gamma-Interferon plasma concentrations and serum immunoglobulin levels were not affected following ten days treatment (600 mg/per day). These data suggest that this antibiotic does not affect the immune parameters studied. However, inhibition of other immune functions cannot be excluded.
authors.affiliation: Cattedra di Immunologia, Università degli Studi Di Bari, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Munno
authors.forename: F
authors.initials: F
authors.lastname: Arpinelli
authors.forename: M
authors.initials: M
authors.lastname: Benedetti
authors.forename: R
authors.initials: R
authors.lastname: Spoglianti
authors.forename: A
authors.initials: A
authors.lastname: Ferlini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007371:Interferon-gamma / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007371:Interferon-gamma; D015242:Ofloxacin