title: [The immunological effectiveness of small doses of diphtheria and tetanus anatoxins in the revaccination of children with allergy-altered reactivity and adults].
abstract: The possibility of decreasing the content of antigens in adsorbed diphtheria-tetanus toxoid, used for the booster immunization of children with allergically altered responsiveness and adults, is shown. Diphtheria toxoid in doses of 1-2.5 Lf and tetanus toxoid in doses of 1-2.5 binding units possessed sufficiently high immunological effectiveness in combination with low reactogenicity and good tolerance. In 6-12 months after booster immunization with decreased doses of toxoids 100% of children with allergy of different character and, respectively, 86-94% and 95% of adults have developed protective levels of antibodies to diphtheria and tetanus.
authors.forename: N A
authors.initials: NA
authors.lastname: Egor'kov
authors.forename: N M
authors.initials: NM
authors.lastname: Maksimova
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
authors.forename: V A
authors.initials: VA
authors.lastname: Fedotov
authors.forename: I A
authors.initials: IA
authors.lastname: Shchukina
authors.forename: Z B
authors.initials: ZB
authors.lastname: Izotova
authors.forename: O I
authors.initials: OI
authors.lastname: Glebova
authors.forename: A N
authors.initials: AN
authors.lastname: Lobanova
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations / Q000008:administration & dosage; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007117:Immunization, Secondary; D008875:Middle Aged; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D013745:Tetanus Toxoid
vernacular_title: Immunologicheskaia éffektivnost' malykh doz difteriĭnogo i stolbniachnogo anatoksinov pri revaktsinatsii deteĭ s allergicheski-izmenennoĭ reaktivnost'iu i vzroslykh.