Synthesis of two new angiotensin II analogs.
The synthesis of two new angiotensin II analogs: [Des-Arg2, epsilon Ahx1]-angiotensin (II (1) and [Des-His0)-angiotensin (II (2) is reported. Rather strong agonist activity shows analog (1)-78% and weak-analog (2)-30% of the contractile activity of angiotensinamide. None of the synthesized peptides has antagonist activity.
Paruszewski
R
R
Department of Pharmaceutical Chemistry, Medical Academy, Warszawa, Poland.
Matusiak
R
R
Janiec
W
W
Folwarczna
J
J
Sliwiński
L
L
Pytlik
M
M
D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D000804:Angiotensin II