[Beta-pancreatic function in adult patients with GH deficiency].
We investigated the beta-pancreatic function in response to a standard oral glucose tolerance test (OGTT) and a tolbutamide test in a group of GH-deficient adult subjects and in a group of control subjects. Fasting plasma glucose levels were normal in all subjects; the insulin levels, basal (0.19 +/- 0.02 vs 0.99 +/- 0.08) and, as n-AUC, after OGTT (195.2 +/- 23 vs 520.5 +/- 69) and tolbutamide test (33.6 +/- 4.4 vs 177.7 +/- 12.1) (means +/- ES), were significantly lower (p less than 0.001) in the GH-deficient subjects compared to controls. These data indicate a reduced beta-cell activity, secondary to absence of trophic effect of GH on pancreatic beta-cells, in GH-deficient adults.
Ardizzi
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Centro Auxologico Italiano di Piancavallo, IRCCS, Università di Milano.
Guzzaloni
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G
Grugni
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Moreni
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G
Sartorio
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Conti
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A
Morabito
F
F
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007515:Islets of Langerhans / Q000503:physiopathology*; D008297:Male; D014044:Tolbutamide
D001786:Blood Glucose; D013006:Growth Hormone; D014044:Tolbutamide
Studio della funzionalità beta-pancreatica in pazienti adulti con deficit di GH.