The application of Fourier-transform Raman spectroscopy to the analysis of pharmaceuticals and biomaterials.
Near infrared Fourier-transform (FT) Raman spectroscopy is shown to be a useful spectroscopic tool for the molecular structural analysis of drugs and biomedical polymers. The technique has been applied to the non-invasive investigation of the hydrolytic degradation of a biodegradable polymer in water over a period of 15 days and to the analysis of a drug within a polymer vehicle over a wide drug concentration range. This work demonstrates the potential value of FT Raman spectroscopy in the field of pharmaceutical science.
Tudor
A M
AM
Department of Pharmaceutical Sciences, University of Nottingham, UK.
Melia
C D
CD
Binns
J S
JS
Hendra
P J
PJ
Church
S
S
Davies
M C
MC
D000812:Anhydrides / Q000032:analysis; D001672:Biocompatible Materials / Q000032:analysis*; D004809:Ephedrine / Q000032:analysis; D005079:Excipients; D005583:Fourier Analysis; D009638:Norepinephrine / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010656:Phenylephrine / Q000032:analysis; D011108:Polymers; D013059:Spectrum Analysis, Raman; D013566:Sympathomimetics / Q000032:analysis
D000812:Anhydrides; D001672:Biocompatible Materials; D005079:Excipients; D004364:Pharmaceutical Preparations; D011108:Polymers; D013566:Sympathomimetics; D010656:Phenylephrine; D004809:Ephedrine; D009638:Norepinephrine