title: Observations on the incidence and significance of linear irregularities in the course of major retinal blood vessels in the fundus of the rat.
abstract: The ophthalmoscopic examination of rats receiving drug administered by daily intravenous bolus injection for 6 months revealed an increase in the incidence and amplitude of linear irregularities in retinal blood vessels with a tendancy towards tortuosity which appeared to be related to treatment. Subsequent critical observation of groups of untreated rats, and rats dosed orally with a vasodilator suggest this phenomenum may be related to haemodynamic mechanisms; and that more attention should be given to the dose volume administered intravenously in this species to avoid the detection of such ocular artefacts.
authors.affiliation: Smithkline Beecham Pharmaceuticals, Essex, England.
authors.forename: A C
authors.initials: AC
authors.lastname: Buckwell
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity; D005260:Female; D005654:Fundus Oculi; D007275:Injections, Intravenous; D008297:Male; D010781:Photography; D051381:Rats; D011919:Rats, Inbred Strains; D012171:Retinal Vessels / Q000187:drug effects*; D014665:Vasodilator Agents / Q000633:toxicity
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents