title: Tissue plasminogen activator followed by percutaneous transluminal coronary angioplasty: one-year TIMI phase II pilot results. TIMI Investigators.
abstract: The TIMI phase II pilot study enrolled 288 patients with acute myocardial infarction who were treated with recombinant tissue plasminogen activator (rt-PA) within 4 hours of symptom onset and who were assigned to coronary angioplasty of the infarct-related vessel 18 to 48 hours after rt-PA treatment. The patients were followed to ascertain (1) vital status; (2) whether they suffered a recurrent myocardial infarction; (3) whether they received coronary angioplasty or bypass grafting; and (4) whether they were rehospitalized for a cardiac event. Risk factors for these events or combination of these events were identified and reported. The estimated 6-week, 6-month, and 1-year cumulative event rate of death or myocardial infarction was 9.1 +/- 1.7%, 12.9 +/- 2.0%, and 13.6 +/- 2.0%, respectively. With the exception of repeat hospital admissions, most of the above cardiac events occurred early during the patients' follow-up course. Cox proportional hazard analyses revealed that continuing chest pain after rt-PA administration, history of congestive heart failure, low systolic blood pressure at the time of initial evaluation, and history of hypertension increased the risk of death or recurrent myocardial infarction, while a history of chest discomfort at baseline evaluation and older age was predictive of future hospitalization or a revascularization procedure.
authors.affiliation: Maryland Medical Research Institute, Incorporated, Baltimore, MD 21210.
authors.forename: B R
authors.initials: BR
authors.lastname: Chaitman
authors.forename: B W
authors.initials: BW
authors.lastname: Thompson
authors.forename: M J
authors.initials: MJ
authors.lastname: Kern
authors.forename: M G
authors.initials: MG
authors.lastname: Vandormael
authors.forename: M B
authors.initials: MB
authors.lastname: Cohen
authors.forename: N A
authors.initials: NA
authors.lastname: Ruocco
authors.forename: R E
authors.initials: RE
authors.lastname: Solomon
authors.forename: E
authors.initials: E
authors.lastname: Braunwald
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001794:Blood Pressure; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy*; D010865:Pilot Projects; D011379:Prognosis; D012008:Recurrence; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator