L-threodops increases extracellular norepinephrine levels in the brain: an in vivo study.
Extracellular norepinephrine levels in the striatum of normal rats increased significantly following the administration of L-threodops. When peripheral decarboxylase activity was inhibited with carbidopa, administration of the same dose of L-threodops induced a 2.5-fold greater increase in norepinephrine levels.
Brannan
T
T
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
Bhardwaj
A
A
Yahr
M D
MD
D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis*; D015103:Droxidopa / Q000494:pharmacology*; D005110:Extracellular Space / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012694:Serine / Q000031:analogs & derivatives*
D012694:Serine; D015103:Droxidopa; D002230:Carbidopa; D009638:Norepinephrine