title: [Atopic dermatitis. IV. The role of proteinase inhibitors in the pathogenesis, assessment of the severity and the prognosis of the disease].
abstract: Examinations of 59 patients with atopic dermatitis have revealed increased content of the major inhibitors of proteinases, a relationship between the patients' age and alpha 2-macroglobulin level in both the patients and the reference group normal subjects. Detection of correlations between alpha 1-proteinase inhibitor and serum IgE as well as between C1 inactivator and C3c have lead to a supposition on the contribution of proteinase inhibitors in the modulation of immune reactions. Clinical features of atopic dermatitis in alpha 1-proteinase inhibitor deficiency and in various blood serum IgE levels are discussed.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Sergeev
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Reznikov
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood; D003876:Dermatitis, Atopic / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011480:Protease Inhibitors / Q000097:blood*
chemical_list: D011480:Protease Inhibitors; D007073:Immunoglobulin E
vernacular_title: Atopicheskiĭ dermatit. IV. Rol' ingibitorov proteinaz v patogeneze, otsenke tiazhesti i prognoze zabolevaniia.