Feline E. coli bacteremia--effects of misoprostol/scavengers or methylprednisolone on hemodynamic reactions and gastrointestinal mucosal injury.
Live E. coli were infused i.v. in cats to induce gastrointestinal mucosal injury and the gastric mucosa was exposed to bile and a luminal pH of 1. A gastric lesion index was calculated and intestinal injury was graded. The effects of i.v. methylprednisolone before and after induction of bacteremia were compared with those of intragastric misoprostol combined with i.v. superoxide dismutase (SOD) and catalase and with a control group. Methylprednisolone, but not misoprostol/SOD/catalase, significantly reduced the gastric lesion index (p less than 0.05). The duodenum/small intestine was significantly injured in 4/6, 2/6 and 4/6 cats in the misoprostol/SOD/catalase, methylprednisolone and control groups, respectively (NS). End gastric luminal pH was 3.9, 2.7 and 4.5 in the respective groups (p less than 0.05), with systemic arterial pH 7.15, 7.15 and 7.32 (NS). Mean arterial pressure and cardiac output were improved with methylprednisolone. Misoprostol/SOD/catalase reduced late hypotension. Pulmonary arterial pressure rose to c. 200% of basal in all groups. Methylprednisolone, but not misoprostol/SOD/catalase, thus protected the gastric mucosa from sepsis-induced gastric injury concomitant with reduced disappearance of protons from the gastric lumen, but did not significantly affect small-bowel damage. Hemodynamic responses were significantly improved in methylprednisolone-pretreated cats.
Arvidsson
S
S
Department of Surgery, University of Lund, Malmö General Hospital, Uppsala, Sweden.
Fält
K
K
Haglund
U
U
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D002374:Catalase / Q000008:administration & dosage*; D002415:Cats; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000187:drug effects*; D008775:Methylprednisolone / Q000008:administration & dosage*; D016595:Misoprostol; D009102:Multiple Organ Failure / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy*; D013276:Stomach Ulcer / Q000188:drug therapy; D013482:Superoxide Dismutase / Q000008:administration & dosage*
D000897:Anti-Ulcer Agents; D016595:Misoprostol; D002374:Catalase; D013482:Superoxide Dismutase; D000527:Alprostadil; D008775:Methylprednisolone