title: [Intrathecal synthesis of immunoglobulins during acute viral meningitis with high cerebrospinal fluid protein levels].
abstract: The article deals with the results of examination of immunoglobulins (IgM, IgA, IgG) in the liquor and serum of 50 patients with acute viral meningitis and hyperproterinorashia over 1.0 g/l. The quantitative determination of immunoglobulins was done by the method of radial immunodiffusion according to Manzoni. The confirmation of intrathecal synthesis of immunoglobulins was done by liquor indexes. IGM intrathecal synthesis was found in 11 (22%) patients, IgA in 16 (32%) and IgG in 10 (20%) subjects. The daily amount of IgG synthesis in the central nervous system was 1.65-97.15 mg (mean 26.60 mg). The values of liquor indexes were decreased in later disease. This suggested the decrease of disappearance of immunoglobulin intrathecal synthesis. There were 26 control patients with meningism (meningeal syndrome with regular cytobiochemical finding in the liquor). IgG intrathecal synthesis was established in one patient with meningism. This finding was an extremely rare and unusual finding.
authors.affiliation: Dr. Kosta Todorović Institute of Infectious and Tropical Disease, University Clinical Centre, Belgrade.
authors.forename: S
authors.initials: S
authors.lastname: Nikolić
authors.forename: M
authors.initials: M
authors.lastname: Vujosević
mesh_terms: D000208:Acute Disease; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000276:immunology
chemical_list: D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins
vernacular_title: Intratekalna sinteza imunoglobulina u toku akutnih virusnih meningitisa sa hiperproteinorahijom.