[Effects of combination chemotherapy with topical application of 5-FU ointment to mice's tongue and UFT].
After oral administration of UFT and lingual topical application of 5-FU ointment to normal mice, the change of the concentration of 5-FU and Uracil in the tongue, liver and blood serum were studied. We compared with UFT only group, 5-FU ointment only group and the both combination chemotherapy group. 1. As for the tongue concentrations, 5-FU levels in both combination chemotherapy group and 5-FU ointment only group were higher compared to UFT only group. There was no difference between combination chemotherapy and 5-FU ointment only group. Uracil at 21-days in combination chemotherapy group were higher than others. 2. The liver concentrations of 5-FU at 21-days was significantly higher. 3. The blood serum concentrations of 5-FU in both combination chemotherapy and 5-FU ointment only groups revealed similar results. Thereafter, combination chemotherapy in oral region with topical application of 5-FU ointment and UFT may be effective.
Tateishi
A
A
First Dept. of Oral Surgery, Kyushu Dental College.
Sakaki
Y
Y
Kameyama
Y
Y
Hara
I
I
Yamada
N
N
D000284:Administration, Oral; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009824:Ointments; D005641:Tegafur / Q000008:administration & dosage / Q000493:pharmacokinetics; D014059:Tongue / Q000378:metabolism*; D014498:Uracil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D009824:Ointments; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil