title: Clinical evaluation of hypothermic ventricular fibrillation, multi-dose blood cardioplegia, and single-dose Bretschneider cardioplegia in coronary surgery.
abstract: 37 patients undergoing coronary revascularization were randomly assigned to three protocols for intraoperative myocardial protection: hypothermic ventricular fibrillation (HF) (n = 13), multi-dose blood cardioplegia (BCP) (n = 12) and single-dose Bretschneider's crystalloid cardioplegia (CCP) (n = 12). As intraoperative markers of ischemic damage myocardial ultrastructure, ATP, and CP contents were determined in left ventricular biopsy specimens taken before and after cardiac arrest. Release of serum enzymes (CK, CK-MB, LDH, SGOT) was determined pre- and postoperatively. Hemodynamic data were assessed before, during, and after operation. The incidence of low cardiac output, positive inotropic support, intraaortic balloon counterpulsation, peri-operative myocardial infarction, rhythm disturbances, and the rate of spontaneous defibrillation was compared between groups. The results show a better preservation of high energy phosphates in the BCP group as compared to the HF and CCP groups. Myocardial ultrastructure showed moderate ischemic damage in the hypothermic fibrillation group; in contrast, only slightly deteriorated cells were seen after cardiac arrest, when cardioplegia was used. The incidence of rhythm disturbances was 25% for HF and 42% for CCP. In contrast, only 17% of new rhythm disturbances were seen in the BCP group. Functional recovery (i.e. CI and SWI) of hearts protected with BCP was generally greater as compared to HF and CCP. Release of MB-creatine-kinase isoenzyme was higher in the HF group as compared to cardioplegia. Clinical outcome in terms of incidence of peri-operative infarction, positive inotropic support and low cardiac output was superior in the BCP group but not significantly different between groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Thoracic- and Cardiovascular Surgery, J. W. Goethe-University, Frankfurt/M, West-Germany.
authors.forename: F
authors.initials: F
authors.lastname: Beyersdorf
authors.forename: E
authors.initials: E
authors.lastname: Krause
authors.forename: K
authors.initials: K
authors.lastname: Sarai
authors.forename: B
authors.initials: B
authors.lastname: Sieber
authors.forename: N
authors.initials: N
authors.lastname: Deutschländer
authors.forename: G
authors.initials: G
authors.lastname: Zimmer
authors.forename: L
authors.initials: L
authors.lastname: Mainka
authors.forename: S
authors.initials: S
authors.lastname: Probst
authors.forename: M
authors.initials: M
authors.lastname: Zegelman
authors.forename: W
authors.initials: W
authors.lastname: Schneider
mesh_terms: D002314:Cardioplegic Solutions / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006324:Heart Arrest, Induced / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology; D011189:Potassium Chloride / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology
chemical_list: C039984:Bretschneider cardioplegic solution; D002314:Cardioplegic Solutions; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D005947:Glucose