Synthesis and biological activity of novel carbocyclic nucleosides.
The syntheses of several novel carbocyclic nucleosides which incorporate the cyclopentene moiety of neplanocin A will be presented. These include modified pyrimidine derivatives of the very potent antitumor agent cyclopentenyl cytosine and carbocyclic analogues of the ketohexose nucleosides psicofuranine and psicofuranosyl cytosine.
Marquez
V E
VE
Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Bodenteich
M
M
Copp
R R
RR
Lim
B B
BB
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry; D003562:Cytidine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D009705:Nucleosides; D003562:Cytidine; C045911:cyclopentenyl cytosine; C031096:neplanocin A; D000241:Adenosine; C014174:psicofuranine