title: [Activity of cefapirin against bacterial strains isolated from acute otitis media in children].
abstract: The antibacterial activity of cefapirin was tested against 210 strains isolated from the auricular exudate of childrens' acute otitis media. For 112 strains of Haemophilus studied (20% secreted a beta-lactamase), the MIC 50 and 90 of cefapirin were 2 and 4 mg/l respectively. Ten strains of Branhamella catarrhalis were tested (9 secreted a beta-lactamase) and the MIC ranged from 0.25 to 4 mg/l. Against Streptococcus pneumoniae, cefapirin has an extremely high activity with MIC 50 and 90 less than 0.06 mg/l. Of the strains of Staphylococcus aureus sensitive to meticillin, one had a MIC less than 0.06 mg/l, and 11 had a MIC = 0.25 mg/l. For 14 strains of Enterobacteriaceae studied, we obtained a MIC 50 of 8 mg/l and a MIC 90 of 32 mg/l. The results show that cefapirin is an antibiotic particularly suitable for the treatment of acute otitis media.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Simonet
authors.forename: J L
authors.initials: JL
authors.lastname: Herrmann
authors.forename: P
authors.initials: P
authors.lastname: Gehanno
authors.forename: M
authors.initials: M
authors.lastname: Veron
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002514:Cephapirin / Q000494:pharmacology*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects; D006190:Haemophilus / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D001936:Moraxella catarrhalis / Q000187:drug effects; D010033:Otitis Media / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002514:Cephapirin
vernacular_title: Activité de la céfapirine sur des souches bactériennes isolées d'otite moyenne aiguë de l'enfant.