Diagnostic and therapeutic value of testing stimulation of thyroid-stimulating hormone by thyrotropin-releasing hormone in 100 depressed patients.
The thyrotropin-releasing hormone (TRH) test was performed in 100 depressed patients, including 73 patients with a major depressive episode (MDE) according to DSM-III. Thirty-one patients subsequently received an antidepressant with a predominant serotoninergic action (indalpine or citalopram), and 27 patients received a noradrenergic antidepressant (maprotiline). The diagnostic value of the TRH test was not conclusive for any of the subgroups of depressed patients: MDE, MDE with melancholia or MDE in bipolar patients. Similarly, the value of the TRH test in the choice of antidepressant treatment according to the monoaminergic action was not convincing. These results are discussed in the light of the data of the international literature.
Vanelle
J M
JM
Department of Mental Health and Therapeutics, Sainte-Anne Hospital, Paris-Cochin University Clinic, France.
Poirier
M F
MF
Benkelfat
C
C
Galinowski
A
A
Sechter
D
D
Suzini de Luca
H
H
Lôo
H
H
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D015283:Citalopram / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D010880:Piperidines; D012702:Serotonin Antagonists; D015283:Citalopram; D008376:Maprotiline; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; C018181:indalpine