title: [Determination of the sensitivity of tuberculosis bacteria to pyrazinamide using human macrophage culture].
abstract: Increasing interest is being shown in the antituberculous drug pyrazinamide. An in-vitro model using cultures of human blood macrophages was tested with 8 different Mycobacterium tuberculosis trains. A good correlation was found between the susceptibility of the strains to pyrazinamide and the Kinetics in the macrophage culture.
authors.affiliation: Webb-Waring Lung Institute, University of Colorado Health Sciences Center, Denver.
authors.forename: M
authors.initials: M
authors.lastname: Salfinger
authors.forename: A J
authors.initials: AJ
authors.lastname: Crowle
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011718:Pyrazinamide / Q000494:pharmacology*
chemical_list: D011718:Pyrazinamide
vernacular_title: Bestimmung der Empfindlichkeit von Tuberkulosebakterien gegenüber Pyrazinamid mit Hilfe humaner Makrophagenkultur.