Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.
RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.
Kato
N
N
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
Shimotohno
K
K
VanLeeuwen
D
D
Cohen
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002822:Choriocarcinoma / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007256:Information Systems; D008667:Metalloproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011533:Proviruses / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics; D014158:Transcription, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*; D015032:Zinc / Q000378:metabolism
D004268:DNA-Binding Proteins; D008667:Metalloproteins; D012333:RNA, Messenger; D004247:DNA; D015032:Zinc