title: [Long-term therapy with almitrine dimesilate has no effect on pulmonary hemodynamics at rest and during stress].
abstract: A 6-month double-blind study was conducted in 26 patients suffering from a severe obstructive disturbance of ventilation and respiratory insufficiency to find out the behaviour of blood gases and pulmonary haemodynamics under Almitrin treatment compared with placebo. The acute administration of 75 mg Almitrin resulted in a significant increase of PaO2 by 11.7 mmHg, as well as of PAPR by 4.4 mmHg. Statistical significance was seen only for the systolic pressure of the a. pulmonalis. After subsequent 6-month treatment with 3 x 25 mg Almitrin, a significantly higher PaO2 is seen at T6 than in the control group. Another additional administration of 75 mg Almitrin results in a further increase of PaO2 by 7.7 mmHg. At T6 the behaviour of pulmonary haemodynamics is identical in both groups A and P.
authors.affiliation: Karl-Hansen-Klinik, Bad Lippspringe.
authors.forename: W
authors.initials: W
authors.lastname: Böhning
authors.forename: B
authors.initials: B
authors.lastname: Winkelmann
authors.forename: H
authors.initials: H
authors.lastname: Worth
authors.forename: R
authors.initials: R
authors.lastname: Wettengel
authors.forename: M
authors.initials: M
authors.lastname: Brüch
authors.forename: H W
authors.initials: HW
authors.lastname: Breuer
authors.forename: M L
authors.initials: ML
authors.lastname: Müller-Höhl
authors.forename: J
authors.initials: J
authors.lastname: Nikolaus
mesh_terms: D015765:Almitrine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008134:Long-Term Care; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D012131:Respiratory Insufficiency / Q000188:drug therapy
chemical_list: D015765:Almitrine
vernacular_title: Die Langzeittherapie mit Almitrindimesilat hat keinen Einfluss auf die pulmonale Hämodynamik in Ruhe und unter Belastung.