title: Increase of sulfadiazine effect against Toxoplasma gondii by using watermelon or cantaloupe seeds.
abstract: In an experimental model the anti--Toxoplasma effect of watermelon and cantaloupe seeds, together with sulfadiazine (Sd7.5 and Sd15) given by oral route, were studied. Combination of any of these seeds with the drug was able to increase the survival time and cure some tachyzoite infected mice. The effect was produced either by peeled or complete seeds and more significant results were obtained when Sd7.5 and 10(3) tachyzoite inoculum was used in the model. Some Toxoplasma oocyst infected mice were cured with the seeds alone (75% for watermelon, 37,5 or 50% for cantaloupe. Body weight variations are independent of the treatment with Sd alone or in combination with watermelon or cantaloupe seeds.
authors.affiliation: Departamento de Parasitología, Facultad de Microbiología, Universidad de Costa Rica.
authors.forename: M
authors.initials: M
authors.lastname: Chinchilla
authors.forename: R
authors.initials: R
authors.lastname: Marín
authors.forename: G
authors.initials: G
authors.lastname: Catarinella
mesh_terms: D000818:Animals; D001835:Body Weight; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D012639:Seeds; D013411:Sulfadiazine / Q000627:therapeutic use*; D014122:Toxoplasma / Q000187:drug effects*; D014123:Toxoplasmosis / Q000188:drug therapy
chemical_list: D010936:Plant Extracts; D013411:Sulfadiazine