Acquired haemolytic anaemia due to isohaemagglutinins of donor origin following ABO-minor-incompatible kidney transplantation.
Of 1041 renal allograft transplantations performed in our centre, 142 (13.6%) were carried out with ABO-minor-incompatible kidneys. Anti-recipient ABO antibodies were found in two of 34 patients treated with cyclosporin. These two cases of severe but self-limited haemolysis due to anti-A1 and anti-B, respectively, are reported in detail. Among 108 azathioprine-treated patients no evidence of the disorder was found. The condition should be suspected in any recipient with an unexpected reduction in haematrocrit or other signs of haemolysis after ABO-minor-incompatible organ transplantation.
Povlsen
J V
JV
Department of Clinical Immunology, University Hospital, Aarhus, Denmark.
Rasmussen
A
A
Hansen
H E
HE
Fjeldborg
O
O
Kissmeyer-Nielsen
F
F
Madsen
M
M
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
D000017:ABO Blood-Group System; D003524:Cyclosporins; D006388:Hemagglutinins; D001379:Azathioprine