A low-incidence red cell antigen JAL associated with two unusual Rh gene complexes.
A multilaboratory investigation during several years has identified a low incidence antigen JAL on the red cells of 7 propositi. JAL appears to be associated with two unusual Rh complexes, one of which produces a depressed C antigen and the other a depressed c antigen. Family studies strongly suggest that the JAL antigen is encoded by the RH locus. Anti-JAL has been implicated in haemolytic disease of the newborn and is thus considered to be a clinically significant antibody.
Lomas
C
C
Medical Research Council Blood Group Unit, London, UK.
Poole
J
J
Salaru
N
N
Redman
M
M
Kirkley
K
K
Moulds
M
M
McCreary
J
J
Nicholson
G S
GS
Hustinx
H
H
Green
C
C
D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D007519:Isoantigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D008297:Male; D015337:Multicenter Studies as Topic; D012204:Rh-Hr Blood-Group System / Q000235:genetics* / Q000276:immunology
D007518:Isoantibodies; D007519:Isoantigens; D012204:Rh-Hr Blood-Group System