The effect of ethanol and serotonin on blood vessels of the rat.
In in vitro conditions ethanol dose-dependently contracts the isolated tail artery and aorta of the rat. In concentration 0.03 M ethanol did not change the perfusing pressure in isolated vessels, but potentiated the contracting action of serotonin. In concentration of 0.1 M ethanol did not change the sensitivity of blood vessels to serotonin, and in concentration of 0.3 M inhibited it. Statistically significant changes were observed only in tail artery. The tail artery isolated from the rat receiving a single dose of ethanol (2 g/kg) displayed decreased sensitivity to action of serotonin. Chronic administration of ethanol (6 g/kg/day for 14 days) did not change the serotonin-induced contraction of the isolated tail artery of the rat. The present data indicate that ethanol modifies the sensitivity of rat blood vessels to serotonin.
Malinowska
B
B
Department of Pharmacodynamics, Medical Academy, Białystok, Poland.
Pietraszek
M
M
Chabielska
E
E
Pawlak
D
D
Buczko
W
W
D000818:Animals; D001011:Aorta / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D012701:Serotonin; D000431:Ethanol