Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment.
We report results of allogeneic bone marrow transplantation in an 8-year-old boy with acute megakaryoblastic leukemia characterized by intense fibrosis together with 20% blast cells in the bone marrow, who was transplanted without preceding chemotherapy for remission induction. Conditioning comprised cytosine arabinoside, cyclophosphamide and total body irradiation. The donor was his HLA-identical sister. The patient is well with minor chronic graft-versus-host disease and normal hematologic values 670 days post-transplant.
Bullorsky
E O
EO
Department of Hematology, British Hospital of Buenos Aires, Argentina.
Shanley
C M
CM
Stemmelin
G
G
Venditti
J
J
Lajous
J R
JR
D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications* / Q000601:surgery; D008297:Male; D055728:Primary Myelofibrosis / Q000209:etiology / Q000601:surgery*; D012074:Remission Induction; D014184:Transplantation, Homologous