Response to IL-6 stimulation of human hepatoblastoma cells: production of pancreatic secretory trypsin inhibitor.
LPS-stimulated macrophage conditioned medium and IL-6 markedly stimulated the secretion of PSTI by cultured hepatoblastoma cells. The mechanism underlying the cellular response of IL-6-induced secretion of PSTI was investigated. Among the agents affecting the signal transduction pathways, forskolin significantly induced PSTI secretion whereas PMA or A23187 did not, suggesting that IL-6 induced PSTI secretion is mediated by cAMP dependent protein kinase A.
Yasuda
T
T
Second Department of Surgery, Osaka University Medical School, Japan.
Ogawa
M
M
Murata
A
A
Oka
Y
Y
Uda
K
K
Mori
T
T
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D016207:Cytokines; D006801:Humans; D015850:Interleukin-6 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008213:Lymphocyte Activation; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000096:biosynthesis*; D014361:Trypsin Inhibitors / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
D001685:Biological Factors; D016207:Cytokines; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014361:Trypsin Inhibitors; D005576:Colforsin; D000001:Calcimycin; D014359:Trypsin Inhibitor, Kazal Pancreatic; D003513:Cycloheximide; D013755:Tetradecanoylphorbol Acetate