Kinetic analysis of drug release from hydrogels containing amphoteric surfactants.
A one compartment open model was used in order to describe chloramphenicol release from hydrogels containing amphoteric surfactants as gelling agents. Such interpretation seems to be more profitable than that based on Higuchi's root square equation. Using the proposed model it is possible to consider that drug release takes place from the water phase near the surface of membrane, rather than from the micellar phase in which drug seems to be immobilized.
Bialik
W
W
Department of Applied Pharmacy and Drug Technology, Faculty of Pharmacy, Medical University School of Silesia, Sosnowiec, Poland.
D002626:Chemistry, Pharmaceutical; D005782:Gels; D007700:Kinetics; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013501:Surface-Active Agents / Q000032:analysis / Q000737:chemistry
D005782:Gels; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents