title: HIPDM-SPECT brain imaging in the presurgical evaluation of patients with intractable seizures.
abstract: We report the results of interictal and ictal HIPDM-SPECT brain imaging in 34 patients who eventually underwent temporal lobectomy for treatment of medically intractable complex partial seizures. Interictal studies revealed decreased regional cerebral perfusion (rCP) in the temporal lobe corresponding to the eventual site of surgery in 73% of the patients. Similarly, ictal study demonstrated increased rCP in 93% of the patients. In 69% of the patients, the SPECT studies were able to demonstrate both increased rCP on the ictal scan and decreased rCP on the interictal scan in the same location, corresponding to the eventual site of surgery. These results suggest that interictal and ictal SPECT brain imaging can be easily obtained and provide reliable localizing information in the presurgical evaluation of patients with medically intractable epilepsy.
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis.
authors.forename: W
authors.initials: W
authors.lastname: Shen
authors.forename: B I
authors.initials: BI
authors.lastname: Lee
authors.forename: H M
authors.initials: HM
authors.lastname: Park
authors.forename: A R
authors.initials: AR
authors.lastname: Siddiqui
authors.forename: H H
authors.initials: HH
authors.lastname: Wellman
authors.forename: R M
authors.initials: RM
authors.lastname: Worth
authors.forename: O N
authors.initials: ON
authors.lastname: Markand
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000601:surgery; D002648:Child; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D007462:Iodobenzenes; D008297:Male; D013702:Temporal Lobe / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007462:Iodobenzenes; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine