[Increase of liver enzymes during treatment of myocardial infarct using intravenous nitro-derivatives].
A transitory serum elevation of hepatocellular enzyme alanine-aminotransferase (ALT) and gamma GT is reported during i.v. treatment with nitroderivatives of acute myocardial infarction. authors have reviewed 144 case (105 males and 39 females) admitted to the emergency ward for acute myocardial infarction: of the 144 cases reviewed, 54 males and 16 females (48.6% of the total) presented a significative increase of ALT and gamma GT, up to the maximum value of 220 U/l, during the first week of continuous i.v. therapy with nitroderivatives. This elevation was transient, with return to normal values during the first month. The AA postulate that this increase is dose-dependent, linked to individual susceptibility and possibly due to the production of free oxygen radicals.
Borghi
E
E
I Divisione di Medicina generale, U.S.L. 14, Cecina.
Rossini
D
D
Giomi
N
N
Roventini
L
L
Vecce
R
R
Fontanive
P
P
Schembri
S
S
Maurini
V
V
Carnicelli
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*
D000410:Alanine Transaminase; D005996:Nitroglycerin; D005978:Glutathione
Aumento di enzimi di pertinenza epatica in corso di trattamento dell'infarto miocardico con nitroderivati per via endovenosa.