Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol.
Gossypol acetic acid was administered orally to 35 male volunteers at a dose of 20 mg once a day for 52-70 days in the loading phase and twice a week for 22 months in the maintenance phase. Sperm counts and the serum concentrations of LH, FSH, prolactin, testosterone and oestradiol were monitored regularly during treatment and for a follow-up period of 12 months. At around 90 days after treatment, all treated participants approached or attained azoospermia and remained at this level throughout the maintenance phase. By the end of the follow-up phase, eight treated men were still azoospermic, while sperm counts in the other 27 men were restored to normal levels. The only hormone that changed significantly during and after the treatment was FSH. From the 6th month of the treatment to the end of the follow-up phase, serum concentrations of FSH in the eight participants that reached irreversible azoospermia were significantly higher than in the other 27 men or in controls. It is suggested that monitoring of FSH levels might be of diagnostic use for identifying those participants with irreversible azoospermia during gossypol treatment.
Gu
Z P
ZP
Institute of Materia Medica, Chinese Academy of Sciences, Shanghai.
Wang
Y X
YX
Sang
G W
GW
Wang
W C
WC
Chen
Z X
ZX
Zhao
X J
XJ
Shao
Q X
QX
Jiang
Y
Y
D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005500:Follow-Up Studies; D006072:Gossypol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000097:blood / Q000139:chemically induced; D011388:Prolactin / Q000097:blood*; D011446:Prospective Studies; D011897:Random Allocation; D013076:Sperm Count; D013089:Spermatocidal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D013089:Spermatocidal Agents; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006072:Gossypol; C028178:gossypol acetic acid