A mammary stimulating mitogen(s) from rat muscle: its possible influence in mammary tumorigenesis.
A mitogen has been shown to be present in rat abdominal muscle tissue, which could stimulate rat mammary cells grown in culture. Studies on the in vivo-stimulatory effects on the rat mammary gland, taking increase in DNA synthesis, mitotic index and wholemount preparation as the parameters, affirmed the presence of a mammary stimulating factor in the muscle tissue. Treatment of rat mammary glands with the crude mitogen preparation before and after a single gastric dose of 9,10-dimethyl-1,2-benzanthracene (DMBA), increased the mammary tumor incidence suggesting its possible influence in carcinogen-induced tumorigenesis in rats.
Rao
L S
LS
Biological Chemistry Division, Tata Memorial Centre, Parel, Bombay, India.
Banerji
A P
AP
D015127:9,10-Dimethyl-1,2-benzanthracene; D000005:Abdomen; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology*; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000209:etiology; D009132:Muscles / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000032:analysis* / Q000494:pharmacology
D006133:Growth Substances; D014020:Tissue Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene