Relative bioavailability of (+/-)-verapamil hydrochloride administered in tablets and chewing gum.
The absorption of verapamil administered orally in chewing gum (23.4-29.7 mg) and perorally in tablets (80 mg) to seven healthy volunteers in a study using an open cross-over design, was compared. Following peroral administration the mean +/- SD AUC/D was (5.4 +/- 1.9) x 10(-3) micrograms ml-1 h per microgram dose and after administration of chewing gum (6.6 +/- 2.3) x 10(-3) micrograms ml-1 h per microgram dose (NS). The AUC ratio of verapamil to the metabolite norverapamil was 1.5 after oral and 0.8 after peroral administration, indicating that a part of the verapamil administered in chewing gum was absorbed through the oral mucosa.
Christrup
L L
LL
Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark.
Bonde
J
J
Rasmussen
S N
SN
Rassing
M R
MR
D000328:Adult; D002638:Chewing Gum; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D013607:Tablets; D014700:Verapamil / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002638:Chewing Gum; D013607:Tablets; D014700:Verapamil