Structure of a hepatotoxic pentapeptide from the cyanobacterium Nodularia spumigena.
The structure of a hepatotoxic peptide from the cyanobacterium Nodularia spumigena was determined using 1D and 2D proton nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. The toxin was a cyclic pentapeptide (mol. wt 824.5) with the structure cyclo-(beta-methylisoAsp-Arg-Adda-isoGlu-N-methylde hydrobutyric acid) (Adda: 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid).
Sandström
A
A
Department of Bioorganic Chemistry, University of Uppsala, Sweden.
Glemarec
C
C
Meriluoto
J A
JA
Eriksson
J E
JE
Chattopadhyaya
J
J
D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000633:toxicity*; D000458:Cyanobacteria; D008099:Liver / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism; D010084:Oxidation-Reduction; D014269:Trifluoroacetic Acid / Q000378:metabolism
D001427:Bacterial Toxins; D009842:Oligopeptides; D014269:Trifluoroacetic Acid