title: Tissue-type plasminogen activator: intracoronary applications.
abstract: Intracoronary tissue-type plasminogen activator (t-PA) was employed successfully before, after, or in place of coronary artery angioplasty in four patients referred for emergency cardiac catheterization during evolving myocardial infarction. The potential roles of intracoronary thrombolysis, dose considerations for intracoronary t-PA, factors influencing the choice of plasminogen activator, and safety issues are discussed.
authors.affiliation: Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: A J
authors.initials: AJ
authors.lastname: Tiefenbrunn
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D003328:Coronary Thrombosis / Q000188:drug therapy; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator