Changes in myelinated nerve fibers and skeletal muscle of rats exposed to high doses of permethrin.
Neurological signs and segmental demyelination in a cervical nerve were observed in rats treated orally with permethrin (300 mg/kg/day) for 5 days. Inflammatory and degenerative signals were recorded in the diaphragm muscle. These effects were more intense with the trade grade than with the technical grade product. The possible influence of the percentage of cis:trans isomers on the intensity of the observed effects is discussed.
Cavaliere
M J
MJ
Instituto Adolfo Lutz, São Paulo, Brazil.
Maeda
M Y
MY
Shih
L W
LW
Puga
F R
FR
D000818:Animals; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000473:pathology; D026023:Permethrin; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin