title: Different doses of cefetamet pivoxil (Ro 15-8075) in the treatment of acute uncomplicated gonococcal urethritis in men.
abstract: In an open, dose-finding study, a 100% cure rate was observed in patients suffering from uncomplicated gonococcal urethritis who were treated with a single oral dose of either 1.2 g (n = 10), 0.8 g (n = 11), or 0.4 g (n = 10) of cefetamet pivoxil. The MICs of cefetamet for all gonococcal strains ranged from 0.001 to 0.12 micrograms/ml, and the MIC for 90% of the strains tested was 0.008 micrograms/ml. Cefetamet pivoxil was ineffective against Chlamydia trachomatis in 3 of 31 patients. Side effects were minor.
authors.affiliation: Department of Dermato-Venereology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: T T
authors.initials: TT
authors.lastname: Tio
authors.forename: I R
authors.initials: IR
authors.lastname: Sindhunata
authors.forename: J H
authors.initials: JH
authors.lastname: Wagenvoort
authors.forename: M F
authors.initials: MF
authors.lastname: Michel
authors.forename: E
authors.initials: E
authors.lastname: Stolz
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D015296:Ceftizoxime; C047445:cefetamet pivoxyl