Long arm deletion of chromosome 7 unrelated to original karyotype in recurrent t(8;21) acute myeloblastic leukemia.
We describe a chromosomal abnormality, 7q-, unrelated to the original karyotype in a patient with recurrent t(8;21) acute myeloblastic leukemia. The 7q-, del(7)(q22q34), was seen in otherwise karyotypically normal cells. Cyclophosphamide was administered for 5 months during the maintenance therapy. Our observations indicate that unrelated karyotypes, besides karyotypic evolution, may be implicated in tumor cell heterogeneity and may support the previous documentation of a possibly causal relationship between chemotherapy and development of 7q-. A larger study will be required to elucidate the biologic significance, if any, of the unrelated karyotypes.
Taniwaki
M
M
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Nakagawa
H
H
Tanaka
S
S
Nishigaki
H
H
Horiike
S
S
Nishida
K
K
Tsuda
S
S
Misawa
S
S
Inazawa
J
J
Abe
T
T
D000328:Adult; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D012008:Recurrence; D014178:Translocation, Genetic