Focal experimental epilepsy in rabbits.
The present study aimed at producing a chronic model of focal epilepsy in rabbits. In group A (30 rabbits) 0.05 ml alumina gel was injected in the right sensorimotor cortex, while in group B (10 rabbits) normal saline was injected in the same region. The observation period lasted 70 days. All group A animals developed spontaneous focal or focal initiated seizures that continued throughout the study. The rate of seizures varied in different animals. Both interictal and ictal epileptiform activities were recorded in the ECoGs. Histological examination showed a typical alumina granuloma with gliotic reaction adjacent to the granuloma.
Bostantjopoulou
S
S
2nd University Department of Neurology, Ahepa Hospital, Thessaloniki, Greece.
Katsarou
Z
Z
Milonas
I
I
Taskos
N
N
Logothetis
J
J
D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005071:Evoked Potentials / Q000187:drug effects; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced; D013238:Stereotaxic Techniques
D000536:Aluminum Hydroxide