Influence of hyperbaric oxygenation on bilirubin and ditaurobilirubin auto-oxidation and porphyrin-sensitized photo-oxidation.
Oxygen concentration controls the reaction rate of porphyrin-sensitized photo-oxidation under constant experimental conditions. The rate of bilirubin and ditaurobilirubin auto-oxidation and meso-tetra-(4-sulphonatophenyl) porphine-sensitized photo-oxidation in aqueous solution increases by about 3.5 times in 0.5 MPa of oxygen. Use of hyperbaric oxygenation in the photodynamic therapy of tumours and in the phototherapy of jaundice is proposed.
Jirsa
M
M
Department of Clinical Biochemistry, Charles University, Faculty of Medicine, Prague, Czechoslovakia.
Síp
M
M
Jirsa
M
M
D001663:Bilirubin / Q000031:analogs & derivatives*; D006801:Humans; D006931:Hyperbaric Oxygenation; D010084:Oxidation-Reduction; D010100:Oxygen; D010778:Photochemotherapy; D010789:Phototherapy; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D013654:Taurine / Q000031:analogs & derivatives*
D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D013654:Taurine; C016136:tetraphenylporphine sulfonate; C046673:ditaurobilirubin; D001663:Bilirubin; D010100:Oxygen