title: Effect of vanadium, iodine and their interaction on growth, blood variables, liver trace elements and thyroid status indices in rats.
abstract: A two-factor, two-by-three factorially arranged experiment was performed to ascertain whether iodine affects the response of rats to vanadium deprivation. Male weanling Wistar-Kyoto rats were fed a 16% casein 68% acid-washed ground corn diet for 8 weeks. The variables were supplemental vanadium at 0 or 1 microgram/g and supplemental iodine at 0, 0.33 or 25 micrograms/g. Vanadium deprivation increased thyroid weight and thyroid weight/body weight ratio and decreased the concentration of vanadium in liver. Vanadium and iodine interacted such that, as dietary iodine was increased, plasma glucose increased in the vanadium-deficient rats but decreased in the vanadium-supplemented rats. Also, as dietary iodine was increased, thyroid peroxidase activity decreased; the decrease was more marked in the vanadium-supplemented than the vanadium-deprived rats. The findings suggest that vanadium may have a physiological role affecting iodine metabolism and thyroid function.
authors.affiliation: United States Department of Agriculture, Grand Forks Human Nutrition Research Center, N. Dak.
authors.forename: E O
authors.initials: EO
authors.lastname: Uthus
authors.forename: F H
authors.initials: FH
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects; D004032:Diet; D004347:Drug Interactions; D006128:Growth / Q000187:drug effects; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D007455:Iodine / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D013961:Thyroid Gland / Q000187:drug effects; D014131:Trace Elements / Q000378:metabolism; D014639:Vanadium / Q000494:pharmacology*
chemical_list: D014131:Trace Elements; D014639:Vanadium; D007455:Iodine; D007453:Iodide Peroxidase