Paroxysmal nocturnal hemoglobinuria: a study of 17 cases.
Retrospective analysis of 17 cases of paroxysmal nocturnal hemoglobinuria (PNH) was carried out. The presenting feature of anaemia and hemoglobin of less than 9 gm% were observed in all cases. Fever, jaundice and bleeding tendency were observed in 8, 8 and 7 cases respectively. Bone marrow examination revealed megaloblastic features, erythroid hyperplasia and hypocellularity in 8, 7 and 2 cases respectively. Fourteen cases were refractory to the treatment, while only 3 showed response.
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Department of Hematology, Seth G. S. M. C., Parel, Bombay, Maharashtra.
D000293:Adolescent; D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies