Tretinoin for the treatment of cutaneous graft-versus-host disease.
Chronic graft-versus-host disease (GVHD) of the skin is a common complication of allogeneic bone marrow transplantation. It can be resistant to common methods of systemic immunosuppression. We report successful treatment of a patient with progressive cutaneous GVHD that was resistant to cyclosporine and steroids after allogeneic marrow transplantation for acute myelogenous leukemia using topical tretinoin (Retin-A).
Gryn
J
J
Department of Neoplastic Diseases, Hahnemann University, Philadelphia, PA 19102.
Crilley
P
P
D000287:Administration, Topical; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D014212:Tretinoin