Ovulation and successful pregnancy in a woman with ovarian failure after hypophysectomy and gonadotropin therapy.
A 38-year-old woman ovulated and conceived after administration of human menopausal gonadotropins despite a previous diagnosis of ovarian failure at age 18. Possible explanations include restoration of down-regulated gonadotropin receptors by development of a prolactinoma, spontaneous remission of autoimmune oophoritis, or prior tumor secretion of biologically inert gonadotropins.
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J H
JH
Department of Obstetrics and Gynecology, Cooper Hospital/University Medical Center, Robert Wood Johnson Medical School, Camden, New Jersey.
D000236:Adenoma / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D007016:Hypophysectomy; D008596:Menotropins / Q000627:therapeutic use*; D010049:Ovarian Diseases / Q000188:drug therapy*; D010060:Ovulation; D010911:Pituitary Neoplasms / Q000601:surgery; D011184:Postoperative Period; D011247:Pregnancy
D008596:Menotropins