The effect of hemodialysis and hemoperfusion on serum valproic acid concentration.
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/l yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valproic acid from the body.
Kandrotas
R J
RJ
Moses H. Cone Memorial Hospital, Greensboro, NC.
Love
J M
JM
Gal
P
P
Oles
K S
KS
D005260:Female; D006464:Hemoperfusion / Q000009:adverse effects*; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013226:Status Epilepticus / Q000188:drug therapy; D014635:Valproic Acid / Q000097:blood* / Q000627:therapeutic use
D014635:Valproic Acid