title: Secretory dynamics of growth hormone in an acromegalic patient associated with Graves' disease.
abstract: The dynamics of GH secretion were investigated in an acromegalic patient with Graves' disease during treatment with antithyroid drugs and radioactive iodine. The mean (+/- SE) basal plasma GH levels were 16.5 +/- 0.9 and 7.8 +/- 0.7 micrograms/L during the hyperthyroid and euthyroid states, respectively. There was a positive correlation (r = 0.902) between basal GH and free T4 levels. Twenty-four-hour plasma GH and urinary GH excretion both increased during the thyrotoxic state. Intravenous administration of TRH induced a marked increase in plasma GH levels during euthyroidism and a modest increase when the patient was hyperthyroid, whereas GH release induced by GH-releasing hormone was not altered by thyroid status. These findings suggest that hyperthyroidism stimulated spontaneous GH secretion from the pituitary adenoma, but inhibited the stimulating effect of TRH.
authors.affiliation: Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shimatsu
authors.forename: H
authors.initials: H
authors.lastname: Murabe
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Tanoh
authors.forename: H
authors.initials: H
authors.lastname: Imura
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000378:metabolism*; D000328:Adult; D006111:Graves Disease / Q000150:complications / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012636:Secretory Rate; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone