The prostacyclin analogue taprostene and recombinant human superoxide dismutase increase the permanent survival rate of endotoxemic rats.
The permanent survival rate of endotoxemic rats was studied. In 40 untreated control rats the survival rate 7 days after the endotoxin administration was 33%. The survival rate was increased to 40% with recombinant human superoxide dismutase (r-HSOD), to 55% (p less than 0.05) with the prostacyclin analogue Taprostene and to 70% (p less than 0.01) with the combination of r-HSOD and Taprostene (20 rats for each treatment group). r-HSOD and Taprostene provide significant and permanent protection in rat endotoxic shock.
Schneider
J
J
Center of Research, Grünenthal GmbH, Aachen, FRG.
Matthiesen
T
T
D000818:Animals; D016009:Chi-Square Distribution; D004357:Drug Synergism; D004731:Endotoxins; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D008168:Lung / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins; D012772:Shock, Septic / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D013482:Superoxide Dismutase / Q000494:pharmacology*; D015996:Survival Rate
D004731:Endotoxins; D011994:Recombinant Proteins; C044101:endotoxin, Escherichia coli; C039188:taprostene; D011464:Epoprostenol; D013482:Superoxide Dismutase