Theophylline plasma clearance in critically ill geriatric patients receiving total parenteral nutrition and in control patients.
Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patients admitted to the Internal Medicine Ward without TPN. All patients were treated with a constant intravenous infusion of aminophylline. Group I patients had a lower mean theophylline clearance of 0.42 +/- 0.23 ml/kg/min compared to Group II 0.64 +/- 0.24 ml/kg/min (P = 0.003).
Sangrador
G
G
Department of Pharmaceutical Services, Lluis Alcanyis Hospital, Xátiva, Spain.
Sánchez-Alcaraz
A
A
Ubeda
R
R
Ibañez
P
P
D000367:Age Factors; D000368:Aged; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000628:therapy; D010289:Parenteral Nutrition, Total; D012044:Regression Analysis; D012907:Smoking; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D013806:Theophylline