The management of heart transplant recipients treated with cyclosporine in Ireland: monitoring of cyclosporine concentrations in blood.
Thirty seven cardiac transplants have taken place at the National Cardiac Centre in Ireland since 1985. Data is presented on three still-surviving male patients aged 19 to 42 who received cardiac transplants in 1985 and 1986. Circulating levels of blood cyclosporine were measured by high pressure liquid chromatography and radioimmunoassay; plasma creatinine and bilirubin were also measured. In one of these patients the distribution of cyclosporine in blood was measured by high pressure liquid chromatography in a long term study. For all three patients cyclosporine levels in blood were compared with the daily dose of cyclosporine and biochemical and histopathological parameters.
Kyne
F
F
Department of Biochemistry, Mater Misericordiae Hospital, Dublin, Ireland.
Maguire
S
S
UaConaill
D
D
O'Broin
S
S
Clarke
E
E
McCann
S
S
Dervan
P
P
Wood
A E
AE
D000328:Adult; D001706:Biopsy; D002851:Chromatography, High Pressure Liquid / Q000592:standards*; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005069:Evaluation Studies as Topic; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D010949:Plasma / Q000737:chemistry; D011863:Radioimmunoassay / Q000592:standards*; D012680:Sensitivity and Specificity
D003524:Cyclosporins