title: Development of a laboratory robotic system for automated bioanalytical methods--II. A robot computer program for guarding totally automated bioanalytical methods.
abstract: The application of fully automated, unattended sample preparation performed by a laboratory robot for the analysis of drugs in biological samples requires the prevention of system failures which may arise in the on-line coupled chromatographic system or in other components of the robotic system. A computer program has been developed which can help to detect such problems. The control program for the robotic sample preparation contains a number of safety measures to intercept robotic or human errors. A routine is implemented, guarding for chromatographic malfunctions and errors in dispensing liquids by the robot. After detection of trouble, sample preparation is interrupted.
authors.affiliation: Pharma Bio-Research International B.V., Assen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Wieling
authors.forename: J
authors.initials: J
authors.lastname: Hempenius
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeuring
authors.forename: J H
authors.initials: JH
authors.lastname: Jonkman
authors.forename: P M
authors.initials: PM
authors.lastname: Coenegracht
authors.forename: D A
authors.initials: DA
authors.lastname: Doornbos
mesh_terms: D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003201:Computers; D006801:Humans; D012371:Robotics; D012984:Software; D013806:Theophylline / Q000097:blood*
chemical_list: D013806:Theophylline