title: [Effect of 4-week metoprolol treatment on clinical manifestations and cardiac hemodynamics in patients with ischemic heart disease].
abstract: Metoprolol was examined for its effects on clinical manifestations of the disease, peripheral hemodynamic and myocardial contractile parameters in 46 patients with coronary heart disease. The examination was performed during an acute drug test and continuous treatment for 4 weeks. The efficiency of the therapy was monitored by conventional clinical tools, bicycle ergometric test, studies of intracardiac hemodynamic parameters from echocardiographic evidence. With metoprolol, its antianginal effect was attained in 67.5% of the patients, there were significant antihypertensive and negative chronotropic effects and moderate cardiodepressive action.
authors.forename: O A
authors.initials: OA
authors.lastname: Vartanova
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage*; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D008790:Metoprolol
vernacular_title: Vliianie 4-nedel'noĭ terapii metoprololom na klinicheskie proiavleniia i kardiodinamiku u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.