Effects of dietary hyperlipidemia-hypercholesterolemia on rat erythrocytes.
We report in the present work that membrane fluidity in erythrocytes from rats under alimentary hyperlipidemia-hypercholesterolemia is slightly diminished despite the fact that in these cells the cholesterol/phospholipid molar ratio is nearly 45% higher than in erythrocytes from control animals. In addition, the erythrocyte count in the rats given the high-fat, high-cholesterol diet was normal. Only a slight reticulocytosis was observed in these animals although their erythrocytes showed a marked decrease in their ability to extrude sodium actively. A tentative explanation for these results is proposed on the basis of other findings suggesting cellular compensatory mechanisms.
de Lucio Cazana
F J
FJ
Department of Physiology and Pharmacology, University of Alcala de Henares, Madrid, Spain.
Rodriguez Puyol
M
M
Perez-Caballero
J
J
Jimenez Jimenez
A
A
Montes Duarte
A
A
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology*; D006937:Hypercholesterolemia / Q000097:blood* / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood* / Q000378:metabolism; D008297:Male; D008560:Membrane Fluidity; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000378:metabolism
D010743:Phospholipids; D002784:Cholesterol