[The immunomodulating action of interferon. The change in the rosette-forming activity of human blood lymphocytes under the influence of gamma-interferon and recombinant alpha 2-interferon].
The authors analyze their findings in the study on the effects of interferon preparations (immune gamma-interferon and recombinant alpha 2-interferon) on the ability of blood lymphocytes of dermatoses patients and normal subjects to enter the rosette formation. Preliminary cell treatment with gamma-interferon in vitro essentially influences lymphocytic rosette forming activity, the initial functional activity of cellular receptor system being of paramount importance here. gamma-interferon increased cellular rosette-forming activity and virtually did not influence the unchanged parameters in the patients with lowered values by spontaneous and early active E-RFC. Besides that immune interferon increased the count of 'heavy' rosettes detectable in spontaneous and active E-rosette formation. Recombinant alpha 2-interferon did not essentially alter the blood lymphocyte receptor system.
Avdeeva
Zh I
ZhI
Mazina
N M
NM
Krylov
O R
OR
Olisova
M O
MO
Lukasheva
T V
TV
Medunitsyn
N V
NV
D000276:Adjuvants, Immunologic; D000328:Adult; D002908:Chronic Disease; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008875:Middle Aged; D011711:Pyoderma / Q000276:immunology; D011994:Recombinant Proteins; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma
K immunomoduliruiushchemu deĭstviiu interferona. Izmenenie rozetkoobrazuiushcheĭ aktivnosti limfotsitov krovi cheloveka pod vliianiem gamma-interferona i rekombinantnogo al'fa 2-interferona.