Treatment of radiation- and chemotherapy-induced stomatitis.
Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy. Most therapeutic regimens are empirical, with no scientific basis. The purpose of this study is to determine the efficacy of various topical solutions in the treatment of radiation- or chemotherapy-induced stomatitis. Eighteen patients were entered into a prospective double-blinded study to test several topical solutions: (1) viscous lidocaine with 1% cocaine; (2) dyclonine hydrochloride 1.0% (Dyclone); (3) kaolin-pectin solution, diphenhydramine plus saline (KBS); and (4) a placebo solution. Degree of pain relief, duration of relief, side effects, and palatability were evaluated. The results showed that Dyclone provided the most pain relief. Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, which averaged 50 minutes This study provides objective data and defines useful guidelines for treatment of stomatitis.
Carnel
S B
SB
Department of Otolaryngology-Head and Neck Surgery Service, Fitzsimons Army Medical Center, Aurora, CO 80045-5000.
Blakeslee
D B
DB
Oswald
S G
SG
Barnes
M
M
D000287:Administration, Topical; D003042:Cocaine / Q000627:therapeutic use; D004155:Diphenhydramine / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D007616:Kaolin / Q000627:therapeutic use; D008012:Lidocaine / Q000627:therapeutic use; D009061:Mouth Mucosa / Q000528:radiation effects*; D010368:Pectins / Q000627:therapeutic use; D011427:Propiophenones / Q000627:therapeutic use; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D014059:Tongue / Q000528:radiation effects
D004338:Drug Combinations; D011427:Propiophenones; C100063:dyclonine; D007616:Kaolin; D010368:Pectins; D004155:Diphenhydramine; D008012:Lidocaine; D003042:Cocaine