title: Functional and morphological relationships between the feline main pancreatic and bile duct sphincters.
abstract: To analyze the relationships between the bile duct and main pancreatic duct sphincters, the resistance to flow through these sphincters was studied simultaneously with perfusion techniques in anesthetized cats. Basal flow resistance was higher in the pancreatic sphincter than in the bile duct sphincter. The pressure in one duct system was not affected by the flow in the other. The muscular activities in the sphincters were usually well coordinated. Distention of the upper biliary tract or the pancreatic duct system reduced the flow resistance in both sphincters. Cholecystokinin-8 (0.01 micrograms), duodenal distention, and sublingual glyceryl trinitrate (0.4 mg) also relaxed both sphincters, whereas secretin in a dose that induced pancreatic secretion had no consistent effect. Morphine increased flow resistance in both systems. These functional studies indicate that the 2 sphincters share smooth muscle fibers at the level where the flow resistances arise, and there are thus no grounds for separate control of the sphincters. There was no evidence of a functionally common sphincter ampulla. The conclusions drawn from the manometric results were supported by morphological findings in this study.
authors.affiliation: Department of Surgery, University of Göteborg, Sahlgrenska Hospital, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Thune
authors.forename: S
authors.initials: S
authors.lastname: Friman
authors.forename: N
authors.initials: N
authors.lastname: Conradi
authors.forename: J
authors.initials: J
authors.lastname: Svanvik
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002415:Cats; D002766:Cholecystokinin / Q000494:pharmacology; D003135:Common Bile Duct / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D010183:Pancreatic Ducts / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D012633:Secretin / Q000494:pharmacology; D009803:Sphincter of Oddi / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology
chemical_list: D012633:Secretin; D009020:Morphine; D002766:Cholecystokinin; D005996:Nitroglycerin