title: Role of HLA class II molecules expressed on hematopoietic progenitor cells.
abstract: The fixation of monoclonal antibodies (MoAb) to the molecule HLA-DR induced an augmentation of thymidine uptake by bone marrow cells, an increased formation of granulo-monocytic colonies and the activation of membrane phospholipase C (PLC) in hematopoietic progenitor cell (HPC) population. The molecule DR expressed on HPC is therefore implicated in signal transduction leading to hematopoietic differentiation.
authors.affiliation: Laboratoire d'Immunogénétique Moléculaire, Institut des Cordeliers, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Mascle
authors.forename: N
authors.initials: N
authors.lastname: Mooney
authors.forename: A
authors.initials: A
authors.lastname: Devergie
authors.forename: E
authors.initials: E
authors.lastname: Gluckman
authors.forename: D
authors.initials: D
authors.lastname: Charron
mesh_terms: D000911:Antibodies, Monoclonal; D002455:Cell Division / Q000276:immunology; D003114:Colony-Forming Units Assay; D006681:HLA-D Antigens / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D006681:HLA-D Antigens; D010738:Type C Phospholipases