title: Possible protein binding displacement interaction between glibenclamide and metolazone.
abstract: The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
authors.affiliation: Department of Clinical Pharmacology, Glenfield General Hospital, Leicester, UK.
authors.forename: S
authors.initials: S
authors.lastname: George
authors.forename: A
authors.initials: A
authors.lastname: McBurney
authors.forename: A
authors.initials: A
authors.lastname: Cole
mesh_terms: D000368:Aged; D001667:Binding, Competitive; D001798:Blood Proteins / Q000378:metabolism*; D003956:Dialysis; D004232:Diuretics / Q000378:metabolism*; D005905:Glyburide / Q000378:metabolism* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008788:Metolazone / Q000378:metabolism* / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects
chemical_list: D001798:Blood Proteins; D004232:Diuretics; D005905:Glyburide; D008788:Metolazone