title: Use of selected visceral protein measurements in the comparison of branched-chain amino acids with standard amino acids in parenteral nutrition support of injured patients.
abstract: Twenty injured patients in the intensive care unit were randomized to receive parenteral nutrition with either 21% (STD) or 46% (HBC) branched-chain amino acids to compare the response of nitrogen balance (NB), somatomedin-C/insulin-like growth factor I (SMC), circulating fibronectin (FBN), and prealbumin (PA). NB was measured and serum collected for SMC, FBN, and PA on days 1, 4, 7, 14, and 21 of nutritional intervention. The treatment groups did not differ significantly for age, weight, injury severity score, trauma score, Apache II score, acute-phase protein concentrations, or type of injury. Comparison of baseline measurements revealed no significant differences in SMC, FBN, or PA. Both groups received similar doses of nonprotein energy and nitrogen. Baseline urea nitrogen excretion was slightly higher in the STD group (216 +/- 55 vs 268 +/- 54 mg/kg/day p = 0.049). Although NB was significantly improved over baseline during subsequent study days, there were no differences between groups after the day-1 measurement. SMC increased significantly from baseline on day 4 in the STD group, on day 7 in the HBC group, and on days 14 and 21 in both groups. There was no significant difference in SMC concentrations between groups on any day. Each group demonstrated a significant increase in PA from baseline on days 7, 14, and 21; however, no difference was seen when groups were compared. FBN increased significantly from baseline on day 14 in the HBC group and on days 7 and 14 in the STD group. FBN measurements were significantly different between groups on day 14 (STD, 179 +/- 71 vs HBC, 229 +/- 59 micrograms/ml; p less than 0.05). NB, PA, SMC, and FBN improve significantly during parenteral nutrition of traumatized patients. With the measured variables, there appears to be no significant difference between STD or HBC amino acids when used as part of parenteral nutrition in injured patients.
authors.affiliation: Department of Clinical Pharmacy, University of Tennessee, Memphis 38163.
authors.forename: D A
authors.initials: DA
authors.lastname: Kuhl
authors.forename: R O
authors.initials: RO
authors.lastname: Brown
authors.forename: K L
authors.initials: KL
authors.lastname: Vehe
authors.forename: B A
authors.initials: BA
authors.lastname: Boucher
authors.forename: R W
authors.initials: RW
authors.lastname: Luther
authors.forename: K A
authors.initials: KA
authors.lastname: Kudsk
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use*; D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D005353:Fibronectins / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D011228:Prealbumin / Q000032:analysis; D011446:Prospective Studies; D011506:Proteins / Q000032:analysis*; D014781:Viscera / Q000032:analysis*; D014947:Wounds and Injuries / Q000097:blood / Q000378:metabolism / Q000628:therapy*
chemical_list: D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D005353:Fibronectins; D011228:Prealbumin; D011506:Proteins; D007334:Insulin-Like Growth Factor I; D009584:Nitrogen