Activation antigens in patients with Sjögren's syndrome.
We report findings of a study of two receptors on mononuclear cells from patients with Sjögren's syndrome (SS). The two receptors, interleukin-2 receptor (IL-2), transferrin receptor (TfR), were identified using monoclonal antibodies anti-IL-2 and OKT9. We found that the IL-2 and TfR positive cells were significantly higher on mononuclear cells (MC) from peripheral blood (PB) of patients with SS than in healthy controls. The study revealed that the IL-2 and TfR positivity reflects systemic immune activation and correlates closely with the activity of SS.
Zeher
M
M
3rd Department of Medicine, Debrecen, University Medical School, Hungary.
Pálóczi
K
K
Szegedi
G
G
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D011990:Receptors, Transferrin / Q000097:blood*; D012859:Sjogren's Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015375:Receptors, Interleukin-2; D011990:Receptors, Transferrin