title: Significance of empty liposomes alone and as drug carriers in dermatotherapy.
abstract: The influence of three different liposome formulations (NAT 106, NAT 50, NAT 89), as empty liposomes and loaded with 0.05% betamethasone, on blood circulation in the corium was investigated by means of laser Doppler flowmetry. All three empty liposomes brought about a decrease in circulation. The maximum effect was reached 90 min after a 30-min occlusive application of the test preparations. Loading with betamethasone resulted in a significant increase in circulation after only 15 min. This increase in interpreted as a steroid effect. No comparable symptoms appeared with the application of base cream DAC (an O/W emulsion) or of betamethasone in base cream under identical experimental conditions.
authors.affiliation: Hautklinik am Städtischen Klinikum, Karlsruhe, and Nattermann Phospholipid GmbH, Cologne, Fed. Rep. of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Gehring
authors.forename: M
authors.initials: M
authors.lastname: Ghyczy
authors.forename: M
authors.initials: M
authors.lastname: Gloor
authors.forename: C
authors.initials: C
authors.lastname: Heitzler
authors.forename: J
authors.initials: J
authors.lastname: Röding
mesh_terms: D001623:Betamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage*; D010316:Particle Size; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply* / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D001623:Betamethasone