Maternal effect on micronucleus induction in MS/Ae mice.
MS/Ae mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.
Sutou
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Itoham Central Research Institute, Ibaraki, Japan.
Sato
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D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D003078:Colchicine / Q000494:pharmacology; D005111:Extrachromosomal Inheritance; D005260:Female; D008098:Litter Size; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D011247:Pregnancy
D008937:Mitomycins; D016685:Mitomycin; D015122:Mercaptopurine; D003078:Colchicine