title: [51Cr]EDTA intestinal permeability in children with cow's milk intolerance.
abstract: Making use of [51Cr]EDTA as a permeability marker, we measured intestinal permeability in a group of 20 children with proven cow's milk intolerance (CMI), a group of 17 children with similar complaints where CMI was excluded (sick controls), and a group of 12 control children. [51Cr]EDTA test results (mean +/- SD) were 6.85 +/- 3.64%, 3.42 +/- 0.94%, and 2.61 +/- 0.67% in the group with CMI, the sick control, and the control group, respectively. When compared to both control groups, patients with cow's milk intolerance (CMI) showed a significantly increased small bowel permeability. We conclude that the [51Cr]EDTA test can be helpful for the diagnosis of cow's milk intolerance.
authors.affiliation: Department of Pediatrics, Academic Hospital Maastricht, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Schrander
authors.forename: R W
authors.initials: RW
authors.lastname: Unsalan-Hooyen
authors.forename: P P
authors.initials: PP
authors.lastname: Forget
authors.forename: J
authors.initials: J
authors.lastname: Jansen
mesh_terms: D000818:Animals; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes; D002986:Clinical Trials as Topic; D004492:Edetic Acid; D005260:Female; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000378:metabolism*; D007787:Lactose Intolerance / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008892:Milk / Q000378:metabolism*; D010539:Permeability; D011877:Radionuclide Imaging
chemical_list: D002860:Chromium Radioisotopes; D004492:Edetic Acid