Effect of polychlorinated biphenyl (Aroclor 1260) on histology of kidney and thyroid of rats.
Gross histological alteration in kidney and thyroid structures were observed in male Wistar rats fed polychlorinated biphenyls (PCBs; Aroclor 1260) at 50 and 100 ppm level in normal commercial diet for 120 days. While the kidney showed glomerulonephritis, degenerative changes in the proximal and distal tubules and increased cellularity of glomeruli, thyroid showed degeneration of follicles, fibrosis of follicles and lymphocytic infiltration followed by thyroiditis.
Rao
C V
CV
Department of Zoology, St. Xavier's College, Bombay, India.
Banerji
S A
SA
D000284:Administration, Oral; D000818:Animals; D001140:Aroclors / Q000008:administration & dosage / Q000633:toxicity*; D005921:Glomerulonephritis / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013966:Thyroiditis / Q000139:chemically induced*
D001140:Aroclors; C026987:aroclor 1260; D011078:Polychlorinated Biphenyls