Propofol in cesarean section. A pharmacokinetic and pharmacodynamic study.
The induction properties and pharmacokinetics of propofol, 2.5 mg/kg i.v., were studied in twelve unpremedicated healthy pregnant patients at term. The onset of anesthesia was rapid (27.7 +/- 7.3 sec) and the quality of induction, maintenance of and rapid recovery from anesthesia were clinically very acceptable. On the basis of Apgar scores and blood gas analyses of the feto-placental unit, propofol appears to be a safe alternative to other available induction agents. The pharmacokinetics of propofol in pregnant women (n = 8) were described by a high value for total body clearance (mean 2189.6 ml/min) and a short elimination half-life (mean 24.1 min). There was no correlation between the pharmacokinetic parameters determined for propofol and some pharmacodynamic observations during the induction of anesthesia (n = 8), nor was there any correlation between drug levels of propofol in the feto-placental unit and blood-gas tensions and pH values or Apgar scores (n = 12).
Kanto
J
J
Dept. of Anesthesiology, Turku University Central Hospital, Finland.
Rosenberg
P
P
D000328:Adult; D000762:Anesthesia Recovery Period; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011247:Pregnancy; D015742:Propofol / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D014469:Umbilical Arteries; D014471:Umbilical Veins
D015742:Propofol