Effects of commonly used NSAID's on gastric mucosa. A clinico-endoscopic and histopathological study.
Non steroidal anti-inflammatory drugs (NSAID's) are one of the most commonly used agents in clinical practice today. All these drugs are known to produce gastro-intestinal lesions. In the present study we found that aspirin, indomethacin and phenylbutazone caused gastric mucosal damage in 90.9%, 100%, respectively while ibuprofen and paracetamol caused gastric mucosal damage in 33.3% and 37.5% respectively. Thus latter two drugs were safer NSAID's. Further more we have demonstrated that endoscopic monitoring of the patients on NSAID's is a sensitive method of early detection of gastric mucosal damage. This monitoring may be particularly valuable in high risk subjects on NSAID's.
Misra
R
R
King Georges Medical College, Lucknow.
Pandey
H
H
Chandra
M
M
Chandra
M
M
Agarwal
P K
PK
Pandeya
S N
SN
D000082:Acetaminophen / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D001241:Aspirin / Q000009:adverse effects; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010113:Oxyphenbutazone / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D010113:Oxyphenbutazone; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin