Change in sphingomyelinase activity in human epidermis during aging.
We have investigated the change in activity of sphingomyelinase in human whole epidermis during aging. The sphingomyelinase activity gradually decreased with the aging process; that of people aged eighty decreased to one fourth of that of people aged twenty in same area. This result indicates that the lipid metabolism may be altered in the epidermis during aging.
Yamamura
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T
Shiga Central Research Laboratories, Noevir Co. Ltd., Japan.
Tezuka
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002518:Ceramides / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000201:enzymology*; D005260:Female; D006801:Humans; D006868:Hydrolysis; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism
D002518:Ceramides; D013109:Sphingomyelins; D013108:Sphingomyelin Phosphodiesterase