In vitro activities of seven quinolone derivatives against Neisseria gonorrhoeae.
The in vitro activities of ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, norfloxacin, ofloxacin, and pefloxacin against 10 penicillinase-producing N. gonorrhoeae strains (PPNG's), 10 non-PPNG's, 10 non-penicillinase-producing penicillin-resistant chromosomally mediated N. gonorrhoeae strains (CMRNG's) 3 N. gonorrhoeae strains with a decreased sensitivity against quinolones compounds and one tetracycline-resistant penicillinase-producing N. gonorrhoeae (TRNG/PPNG), strain were evaluated in this study. The non PPNG, PPNG, CMRNG and TRNG/PPNG strains showed good to excellent sensitivity to the quinolones tested. The N. gonorrhoeae strains with a decreased sensitivity against quinolones showed higher MIC (minimum inhibitory concentration) values.
van der Willigen
A H
AH
Department of Dermatology, University Hospital, Rotterdam-Dijkzigt, The Netherlands.
Degener
J E
JE
Vogel
M
M
Stolz
E
E
Wagenvoort
J H
JH
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006069:Gonorrhea / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010405:Penicillinase / Q000378:metabolism
D042462:4-Quinolones; D000890:Anti-Infective Agents; D010405:Penicillinase