Hepatic toxicity of vitamin A and synthetic retinoids.
Vitamin A and synthetic retinoids have recently been used increasingly in a variety of health related concerns. Hepatic toxicity is an uncommon but serious side-effect of several Vitamin A derivatives which may lead to cirrhosis. This review will focus on the clinical and pathologic findings of hepatic involvement in chronic hypervitaminosis A and on the evidence concerning the potential hepatotoxicity of currently available synthetic retinoids.
Fallon
M B
MB
Yale University School of Medicine, Liver Study Unit, New Haven, Connecticut 06510.
Boyer
J L
JL
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005050:Etretinate / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000209:etiology / Q000473:pathology; D015474:Isotretinoin / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male
D005050:Etretinate; D015474:Isotretinoin