title: Effect of an intravenous gammaglobulin preparation on the opsonophagocytic activity of preterm serum against coagulase-negative staphylococci.
abstract: Recent reports have described cases of septicaemia caused by coagulase-negative staphylococci in preterm neonates, mainly due to the use of artificial intravenous devices. It was of interest to examine if intravenous immunoglobulin therapy, known to be effective in group B streptococcal infections of neonates, had a similar beneficial effect in coagulase-negative staphylococcal infections. Opsonophagocytosis of coagulase-negative staphylococci by normal polymorphonuclear leukocytes in the presence of cord blood serum supplemented with the commercial IgG preparation 'Sandoglobulin' was investigated, using luminol-dependent chemiluminescence. It was found that with two different coagulase-negative staphylococcal strains, Sandoglobulin had a concentration-dependent enhancing effect on the chemiluminescent response. This effect was demonstrated in the presence of native as well as inactivated cord blood serum and in the presence of sera from preterm infants (28-33 weeks). It is concluded that intravenous Sandoglobulin therapy may be effective in the treatment of preterm infants with severe coagulase-negative staphylococcal infections.
authors.affiliation: Department of Pediatrics, Rambam Medical Center, Haifa, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Etzioni
authors.forename: N
authors.initials: N
authors.lastname: Obedeanu
authors.forename: S
authors.initials: S
authors.lastname: Blazer
authors.forename: A
authors.initials: A
authors.lastname: Benderly
authors.forename: D
authors.initials: D
authors.lastname: Merzbach
mesh_terms: D004341:Drug Evaluation; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D007275:Injections, Intravenous; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous