Refeeding after starvation in the rat: comparative effects of lipids, proteins and carbohydrates on jejunal and ileal mucosal adaptation.
To compare the tropic effect of different dietary nutrients on mucosal adaptation in the jejunum and ileum, adult rats were submitted to a 96-h period of starvation and refed isocaloric liquid diets (1.5 kcal ml-1) containing either protein (casein), carbohydrate (starch) or lipids. In the jejunum, 4 days of starvation caused mucosal hypoplasia, villus and crypt shortening and a decrease in the total activity of disaccharidases with the exception of lactase which was markedly enhanced. In contrast, mucosal hypoplasia was incomplete in the ileum which exhibited an increase in crypt depth and in the specific and total activities of disaccharidases and of aminopeptidase. Compared with protein and carbohydrates, lipids exerted the strongest stimulatory effect for mucosal regeneration. In the jejunum as well as in the ileum, mucosal mass parameters, villus length, crypt depth and lactase activity did reverse towards their initial value within 1-3 days of refeeding lipids, even though the animals received only one-third of their normal daily caloric intake. Our results indicate that the pattern of response to fasting differs between the proximal and distal small intestine, and that the intestinal changes induced by starvation are rapidly reversed by refeeding small amounts of a diet rich in fat.
Buts
J P
JP
Paediatric Gastroenterology and Nutrition, University of Louvain, Brussels, Belgium.
Vijverman
V
V
Barudi
C
C
De Keyser
N
N
Maldague
P
P
Dive
C
C
D000818:Animals; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D005502:Food; D007082:Ileum / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D007583:Jejunum / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects*; D013217:Starvation / Q000503:physiopathology*
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins