Long-term results with the Gn-RH analogue, buserelin, in metastatic prostate cancer.
LH-RH analogues have come into use to suppress the synthesis of testosterone by the testes and to induce palliation in advanced prostate cancer. Twenty-one patients were treated with buserelin (Hoe 766), and 19 were evaluable. Stages of disease were D1-D2. Seventeen patients responded to treatment, 3 patients are still in partial response, and 16 underwent progression. The median time to progression was 12 months (range, 3-36), and the median follow-up time was 10 months (mean, 25.4; range, 5-48).
Maffezzini
M
M
Divisione di Urologia, Istituto Scientifico San Raffaele, Milano, Italy.
Villa
E
E
Broglia
L
L
Francesca
F
F
Rigatti
P
P
D000368:Aged; D002064:Buserelin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D002064:Buserelin