Coproduction of surfactin and iturin A, lipopeptides with surfactant and antifungal properties, by Bacillus subtilis.
Of the 13 strains of Bacillus subtilis tested for the coproduction of the lipopeptide surfactin and the antifungal lipopeptides of the iturin family, only 1 produced both lipopeptides with a high yield. The cultures were made in a synthetic medium. Several L-amino acids and various carbon sources were good substrates for the lipopeptide production. The maximum yield of surfactin was about 110 mg/liter and that of iturin A about 39 mg/liter/absorbance unit for the best strain, B. subtilis S 499.
Sandrin
C
C
Laboratoire de Biochimie Microbienne, Université Claude Bernard, Lyon I, France.
Peypoux
F
F
Michel
G
G
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000378:metabolism; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D002855:Chromatography, Thin Layer; D055666:Lipopeptides; D008074:Lipoproteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013501:Surface-Active Agents / Q000302:isolation & purification / Q000378:metabolism*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001426:Bacterial Proteins; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C009365:surfactin peptide; C013579:iturin A