title: The disposition of tert-butyl-D-serine in the rat.
abstract: 1. Following intravenous administration of 14C-tert-butyl-D-serine to rats, radioactivity was eliminated rapidly via the kidneys. 2. One metabolite was detected in urine and was identified as the N-acetyl derivative of tert-butyl-serine. 3. Elimination was more rapid in female than male rats.
authors.affiliation: Drug Metabolism Section, ICI Pharmaceuticals, Macclesfield, UK.
authors.forename: S
authors.initials: S
authors.lastname: Knott
authors.forename: A
authors.initials: A
authors.lastname: Warrander
authors.forename: P J
authors.initials: PJ
authors.lastname: Phillips
authors.forename: J R
authors.initials: JR
authors.lastname: Harding
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D015262:Xenobiotics
chemical_list: D002247:Carbon Isotopes; D015262:Xenobiotics; C063265:tert-butylserine; D012694:Serine