[The effect of thrombocytes on the inhibition of granulocyte adherence induced by the ionophore A 23187 in multiple sclerosis].
In patients with disseminated sclerosis and in a control group inhibition of granulocyte adherence was investigated after stimulation with the ionophore A23187 and the effect of autologous thrombocytes on this reactivity was investigated. The granulocyte adherence was not markedly influenced in the described experimental set-up by the ionophore alone not by incubation with thrombocytes alone. The ionophoretic stimulation of granulocytes incubated with thrombocytes caused marked inhibition of leucocyte adherence in healthy controls and to a significantly smaller extent in patients with multiple sclerosis without corticosteroid treatment. In patients treated with corticosteroids this response was not observed. The results suggest a change of membrane properties, dependent on thrombocytes, in the early stage of non-specific granulocyte activation in patients with multiple sclerosis.
Mayer
M
M
Ustav klinické a experimentální neurologie Univerzity Palackého, Olomouc.
D001792:Blood Platelets / Q000502:physiology*; D000001:Calcimycin / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology
D000001:Calcimycin
Vliv trombocytů na inhibici granulocytární adherence indukovanou ionoforem A23187 u roztrousené sklerózy mozkomísní.