A method to predict the percutaneous permeability of various compounds: shed snake skin as a model membrane.
Penetration of various compounds through shed snake skin was measured in vitro to examine the effect of lipophilicity and molecular size of a compound on permeability through this model membrane. The permeabilities were found to be controlled by the lipophilicity and the molecular size of the permeant. The smaller and the more lipophilic the compound, the greater the permeability. Equations have been developed to predict the permeability from the molecular weight and the distribution coefficient of a compound. Further, the lipophilicity of shed snake skin is similar to that of human skin and the response of shed snake skin to the molecular size of a permeant is more similar to human skin than to hairless mouse skin. Considering the similarities between shed snake skin and human stratum corneum in terms of structure, composition, and permeability characteristics, the same considerations may apply to permeability through human stratum corneum.
Itoh
T
T
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66045.
Magavi
R
R
Casady
R L
RL
Nishihata
T
T
Rytting
J H
JH
D000818:Animals; D002463:Cell Membrane Permeability; D006854:Hydrocortisone / Q000737:chemistry / Q000493:pharmacokinetics; D007052:Ibuprofen / Q000737:chemistry / Q000493:pharmacokinetics; D007213:Indomethacin / Q000737:chemistry / Q000493:pharmacokinetics; D007660:Ketoprofen / Q000737:chemistry / Q000493:pharmacokinetics; D008954:Models, Biological; D008970:Molecular Weight; D009288:Naproxen / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D011374:Progesterone / Q000737:chemistry / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism*; D012911:Snakes
D011374:Progesterone; D009288:Naproxen; D007660:Ketoprofen; D006854:Hydrocortisone; D007052:Ibuprofen; D007213:Indomethacin