title: Quinoline esters as potential antimalarial drugs: effect on relapses of Plasmodium cynomolgi infections in monkeys.
abstract: Two compounds of the quinoline ester series, WR 197236 (6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline ) and WR 194905 (4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonylquinoline++ +), exhibit anti-relapse activity against sporozoite-induced Plasmodium cynomolgi B infections in rhesus monkeys. Both the compounds have been found to be curative when given intramuscularly in 7 daily doses of 15 mg/kg, and no relapses were observed during the observation period of 120 d.
authors.affiliation: Division of Microbiology, Central Drug Research Institute, Lucknow, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000962:Antimalarials; D006912:Hydroxyquinolines; C069167:6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline; C069166:3-heptyl-4-hydroxy-7-methoxy-2-methylquinoline; C069168:4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonylquinoline