Rapid diagnosis of tuberculous meningitis by polymerase chain reaction (PCR).
Using a rapid and highly sensitive method for the diagnosis of tuberculous meningitis by polymerase chain reaction (PCR), we detected the Mycobacterium tuberculosis genome in CSF of 5 of 6 patients with clinically diagnosed tuberculous meningitis. The genome was not present in CSF from 10 patients with other types of meningitis and 10 normal controls.
Kaneko
K
K
Department of Neurology, Niigata University, Japan.
Onodera
O
O
Miyatake
T
T
Tsuji
S
S
D000328:Adult; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction / Q000379:methods*; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000382:microbiology
D004269:DNA, Bacterial