title: Regional cerebral blood flow imaging: a quantitative comparison of technetium-99m-HMPAO SPECT with C15O2 PET.
abstract: The aim of this study was to compare technetium-99m-hexamethylpropyleneamineoxime (99mTc-HMPAO) single-photon emission computed tomography (SPECT) with regional cerebral blood flow (rCBF) imaging using positron emission tomography (PET). As investigation of dementia is likely to be one of the main uses of routine rCBF imaging, 18 demented patients were imaged with both techniques. The PET data were compared quantitatively with three versions of the SPECT data. These were, first, data normalized to the SPECT cerebellar uptake, second, data linearly corrected using the PET cerebellar value and, finally, data Lassen corrected for washout from the high flow areas. Both the linearly-corrected (r = 0.81) and the Lassen-corrected (r = 0.79) HMPAO SPECT data showed good correlation with the PET rCBF data. The relationship between the normalized HMPAO SPECT data and the PET data was nonlinear. It is not yet possible to obtain rCBF values in absolute units from HMPAO SPECT without knowledge of the true rCBF in one reference region for each patient.
authors.affiliation: Department of Bio-Medical Physics and Bio-Engineering, Aberdeen Bio-Medical Imaging Cyclotron Centre, Aberdeen, Scotland, UK.
authors.forename: H G
authors.initials: HG
authors.lastname: Gemmell
authors.forename: N T
authors.initials: NT
authors.lastname: Evans
authors.forename: J A
authors.initials: JA
authors.lastname: Besson
authors.forename: D
authors.initials: D
authors.lastname: Roeda
authors.forename: J
authors.initials: J
authors.lastname: Davidson
authors.forename: M G
authors.initials: MG
authors.lastname: Dodd
authors.forename: P F
authors.initials: PF
authors.lastname: Sharp
authors.forename: F W
authors.initials: FW
authors.lastname: Smith
authors.forename: J R
authors.initials: JR
authors.lastname: Crawford
authors.forename: R H
authors.initials: RH
authors.lastname: Newton
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D002245:Carbon Dioxide; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D015161:Dementia, Multi-Infarct / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002250:Carbon Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D002245:Carbon Dioxide; D019690:Technetium Tc 99m Exametazime