[The effect of thymogen on the cell division processes in the corneal epithelium under physiological conditions and in an experimental thermal burn].
Experimental studies of the influence of a new pharmacologic preparation thymogene on the processes of cellular multiplication of the corneal epithelium in physiologic conditions and thermic burn of the eye in 140 rats. (280 eyes) have shown that in intact animals the preparation produces DNA synthesis in both systemic and local usage, that is most expressed by the 3d-5th day after its administration. The study of the influence of thymogene on reparative processes in rats with corneal burns has shown that administration of the preparation stimulates processes of cellular population in the corneal epithelium both in the early period (on the 3d day) and by the 14th day after burn trauma. This allows to consider thymogene a perspective preparation for a quicker healing of the cornea after burn trauma.
Koz'mova
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D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D065306:Corneal Injuries; D004151:Dipeptides; D004353:Drug Evaluation, Preclinical; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005126:Eye Burns / Q000188:drug therapy* / Q000473:pathology; D007273:Injections, Intramuscular; D008940:Mitotic Index / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; C060736:thymogen
Vliianie timogena na protsessy kletochnogo deleniia épiteliia rogovitsy v fiziologicheskikh usloviiakh i pri termicheskom ozhoge v éksperimente.