Patients with erosive lichen planus may have antibodies directed to a nuclear antigen of epithelial cells: a study on the antigen nature.
Two patients with erosive lichen planus and latent HBV infection who had circulating antibodies directed to nuclei of epithelial cells are described. The nature of such antigen has been investigated by indirect immunofluorescence, double immunodiffusion, counterimmunoelectrophoresis, enzyme-linked immunosorbent assay, enzyme treatments, and immunoblotting. The antigen cannot be identified as RNP, histone, soluble nuclear protein, nDNA, or ssDNA. It may be a DNA protein complex and preliminary immunoblotting data support the thesis that it may be a multimolecular complex.
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Department of Dermatology, University of Genoa, Italy.
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D034961:Antigens, Nuclear; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D015151:Immunoblotting; D005779:Immunodiffusion; D007122:Immunoelectrophoresis / Q000379:methods; D008010:Lichen Planus / Q000276:immunology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000276:immunology; D009061:Mouth Mucosa; D009687:Nuclear Proteins / Q000276:immunology*
D034961:Antigens, Nuclear; D009687:Nuclear Proteins