title: Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells.
abstract: We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-1-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release. These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium, which might be involved in the developments of vascular complications and atherosclerosis.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
authors.forename: K
authors.initials: K
authors.lastname: Ohnaka
authors.forename: R
authors.initials: R
authors.lastname: Takayanagi
authors.forename: F
authors.initials: F
authors.lastname: Umeda
authors.forename: H
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D002417:Cattle; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D016232:Endothelins; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D008353:Mannitol / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism*; D010793:Phthalazines / Q000494:pharmacology
chemical_list: D016232:Endothelins; D010455:Peptides; D010793:Phthalazines; C042829:ponalrestat; D008353:Mannitol; D005947:Glucose