title: Retrospective study of lithium use for institutionalized mentally retarded individuals with behavior disorders.
abstract: Severely and profoundly mentally retarded institutionalized residents (N = 74) who received lithium carbonate for various behavior disorders were followed in a 10-year retrospective study. Their disorders had not been responsive to other medications or treatments. Behavioral data had been recorded regularly and coordinated with medication use. Subjects who demonstrated a sustained major reduction or elimination of behavioral symptoms were classified as lithium responders (n = 31). Characteristics that indicated greater likelihood of response included older age and presenting symptoms of psychosis, although all characteristics studied were seen in both the responder and nonresponder group.
authors.affiliation: Clinical Faculty, University of Florida College of Medicine.
authors.forename: H R
authors.initials: HR
authors.lastname: Langee
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008094:Lithium / Q000008:administration & dosage*; D016651:Lithium Carbonate; D008297:Male; D012189:Retrospective Studies; D012652:Self Mutilation / Q000188:drug therapy; D012920:Social Behavior Disorders / Q000188:drug therapy* / Q000523:psychology
chemical_list: D016651:Lithium Carbonate; D008094:Lithium