title: The role of immunocytochemical assays in the diagnosis of stereotactic biopsies from intracranial tumors.
abstract: A selected panel of monoclonal antibodies (MoAbs) directed to distinct tumor associated antigens (TAA) has been tested to define the capability of these reagents to differentiate among metastatic carcinoma, lymphoma and primary brain tumor on cytologic specimens obtained with stereotactic techniques. Results obtained on 50 patients bearing either single or multiple brain lesions demonstrated that immunocytochemical (ICC) methods can distinguish between primary brain tumor and brain metastasis suggesting, in 90% of patients with cryptic primary neoplasia, the site of origin of the tumor.
authors.affiliation: National Institute for Cancer Research, Regina Elena, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mottolese
authors.forename: C M
authors.initials: CM
authors.lastname: Carapella
authors.forename: M
authors.initials: M
authors.lastname: De Santis
authors.forename: R
authors.initials: R
authors.lastname: Mastrostefano
authors.forename: L
authors.initials: L
authors.lastname: Raus
authors.forename: M
authors.initials: M
authors.lastname: Salzano
authors.forename: N
authors.initials: N
authors.lastname: Pericoli
authors.forename: A
authors.initials: A
authors.lastname: Riccio
authors.forename: P G
authors.initials: PG
authors.lastname: Natali
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001706:Biopsy / Q000379:methods; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000175:diagnosis; D013238:Stereotaxic Techniques
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm