Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins.
The interaction of alpha-, beta- and gamma-cyclodextrins with the anthracycline antibiotics doxorubicin and daunorubicin was investigated by LC, circular dichroism (CD) and absorption spectroscopy. All studies were performed in aqueous media at different temperatures and pH values. The anthracyclines complex only with gamma-cyclodextrin. Lineweaver-Burk and Scott's plots were used to calculate the stability constants of the anthracycline-gamma-cyclodextrin inclusion complexes.
Bekers
O
O
Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
Beijnen
J H
JH
Otagiri
M
M
Bult
A
A
Underberg
W J
WJ
D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet
D003505:Cyclodextrins; D004317:Doxorubicin; D003630:Daunorubicin