Studies of pyrimidine metabolism during chick development: two enzymes involved in UMP breakdown.
The pattern of uridylate phosphatase and uridine phosphorylase has been studied in the liver, brain, heart and thigh muscles of the chick during development. The study of enzymes involved in pyrimidine metabolism confirms that differences in utilisation of the metabolic pathways exist during ontogenesis. In the liver, starting from the 12th day, an active metabolic pathway, leading to UMP via cytosine should be added to the catabolic ones. In the brain, the second period of embryogenesis should be characterized by a lower utilisation of the catabolic pathways and by an increase of the anabolic ones. In the heart, pyrimidine metabolism during development regards especially UMP. In skeletal muscle, pyrimidine metabolism shows low activity.
Wegelin
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Istituto di Istologia ed Embriologia generale, Università di Bologna.
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D015720:5'-Nucleotidase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology; D002642:Chick Embryo / Q000201:enzymology*; D006321:Heart / Q000196:embryology; D006868:Hydrolysis; D008099:Liver / Q000196:embryology / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D014542:Uridine Monophosphate / Q000378:metabolism*; D014543:Uridine Phosphorylase / Q000378:metabolism*
D014542:Uridine Monophosphate; D014543:Uridine Phosphorylase; D015720:5'-Nucleotidase