Can growth hormone increase, after clonidine administration, predict the dose of human menopausal hormone needed for induction of ovulation?
Recent observations claimed that growth hormone (GH) administration increased the sensitivity of the ovary to gonadotropin stimulation. These findings prompted us to assess whether ovarian response to human menopausal gonadotropin (hMG) is correlated to GH reserve. Before hMG administration, 25 patients were tested for GH reserve by administration of clonidine. Of the 25 patients, 8 showed a significant increase in GH (9.2 +/- 4.5 ng/mL) and needed a significantly lower dose of hMG/human chorionic gonadotropin to elicit a good ovarian response than the 17 patients who did not respond to clonidine administration may help to estimate the initial dose range of hMG necessary for induction of ovulation.
Menashe
Y
Y
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Lunenfeld
B
B
Pariente
C
C
Frenkel
Y
Y
Mashiach
S
S
D000284:Administration, Oral; D000328:Adult; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008596:Menotropins / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction
D008596:Menotropins; D013006:Growth Hormone; D003000:Clonidine