title: [Lyophilized cartilage--an antibiotic carrier].
abstract: Human lyophilized bruised costal cartilage was tested in vitro for its ability to act as a carrier medium for antibiotics. A remarkable capacity of accumulating streptomycin, gentamicin, tobramycin, vancomycin and ciprofloxacin was observed; whereas beta-lactum antibiotics and fosfomycin were released at a high rate. This release pattern was not influenced by the sterilization procedure, but rather by the size of the cartilage granula. Lyophilized cartilage--rehydrated in antibiotic-solutions--be helpful adjunct in the surgical management of osseous infections.
authors.affiliation: Universitätsklinik für Zahn-, Mund- und Kieferheilkunde, Innsbruck.
authors.forename: W
authors.initials: W
authors.lastname: Puelacher
authors.forename: F
authors.initials: F
authors.lastname: Allerberger
authors.forename: E
authors.initials: E
authors.lastname: Waldhart
authors.forename: E
authors.initials: E
authors.lastname: Semenitz
authors.forename: M P
authors.initials: MP
authors.lastname: Dierich
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002356:Cartilage / Q000502:physiology*; D005612:Freeze Drying; D006801:Humans; D014677:Pharmaceutical Vehicles
chemical_list: D000900:Anti-Bacterial Agents; D014677:Pharmaceutical Vehicles
vernacular_title: Lyophilisierter Knorpel--ein Antibiotikaträger.