title: Circadian variation of methyleugenol anesthesia in albino rats.
abstract: In Wistar rats synchronized to a 12-h light/12-h dark cycle (lights on from 08:00 to 20:00 h), the ip injection of methyleugenol (200 mg/kg) at 08:00, 12:00 and 16:00 h significantly increased the sleeping time (time between loss and recovery of righting reflex) when compared to animals anesthetized at 20:00, 24:00 and 04:00 h. These data provide another example of the importance of circadian rhythms in biological systems and their practical relevance to pharmacology.
authors.affiliation: Departamento de Fisiologia, Universidade Federal do Rio Grande do Norte, Natal, Brasil.
authors.forename: M B
authors.initials: MB
authors.lastname: Sousa
authors.forename: M F
authors.initials: MF
authors.lastname: Ximenes
authors.forename: M T
authors.initials: MT
authors.lastname: Mota
authors.forename: L F
authors.initials: LF
authors.lastname: Moreira
authors.forename: A A
authors.initials: AA
authors.lastname: Menezes
mesh_terms: D000758:Anesthesia; D000777:Anesthetics; D000818:Animals; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D005054:Eugenol / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000777:Anesthetics; C005223:methyleugenol; D005054:Eugenol