[Immunoglobulin class and light chain type of oligoclonal bands in CSF in children with CNS infectious diseases].
Agarose gel electrophoresis and immunofixation of CSF and serum from 16 patients aged from 1 day to 13 years with CNS infectious diseases (5 with purulent meningitis, 5 with aseptic meningitis, 4 with acute encephalitis, 1 with subdural empyema and 1 with SSPE) revealed oligoclonal IgG bands in 10 cases. In 4 cases, a high CSF/serum albumin ratio was recognized without an increase of IgG-index, probably representing a systemic immune response. Neither IgA nor IgM bands were recognized. IgG light chain was examined in 7 cases and IgG kappa bands predominated in 6 cases. IgG lambda bands predominance presented in only one case. Free IgG kappa or lambda chain was not found. These results suggested that the measurement of not only IgG-index but oligoclonal bands may have a diagnostic usefulness to know about local production of immunoglobulins in CSF.
Sakuta
R
R
Department of Pediatrics, Nihon University School of Medicine, Tokyo.
Hiyoshi
K
K
Yanagida
K
K
Fujita
Y
Y
Okubo
O
O
Utsumi
Y
Y
D000293:Adolescent; D002493:Central Nervous System Diseases / Q000276:immunology*; D002555:Cerebrospinal Fluid / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000276:immunology*
D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins