Day-case surgery: enhanced recovery with flumazenil.
In an open, randomized, parallel group study of 84 adult patients undergoing elective day-case urological surgery the specific benzodiazepine antagonist flumazenil was shown to reverse effectively subjective postoperative sedation due to midazolam and enabled 83% of patients to recover and be ready for potential discharge within 15 min of surgery (control group 24% p less than 0.001). The significantly shorter recovery time has benefits in terms of increased patient cooperation and reduced demands on postoperative nursing care. The implications of these findings for day-case surgery are discussed.
Birch
B R
BR
Department of Minimally Invasive Surgery, Royal Northern Hospital, London.
Anson
K M
KM
Clifford
E
E
Miller
R A
RA
D000328:Adult; D000368:Aged; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage*; D006801:Humans; D008012:Lidocaine; D008297:Male; D008874:Midazolam / Q000037:antagonists & inhibitors; D008875:Middle Aged; D011184:Postoperative Period; D016032:Randomized Controlled Trials as Topic; D014570:Urologic Diseases / Q000601:surgery*
D005442:Flumazenil; D008012:Lidocaine; D008874:Midazolam