Arachidonic acid metabolites in carbon tetrachloride-induced liver injury.
The changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue of rats with carbon tetrachloride (CCl4)-induced liver injury were studied. As a result, after the administration of CCl4, the levels of LTs increased at an early stage while the levels of PGs increased at a later stage. This suggests that LTs may have an adverse effect on liver injury induced by CCl4, and that PGs may not have a direct effect on liver injury. In addition, serum GOT and GPT levels improved with the administration of AA-861, a 5-lipoxygenase inhibitor, while these levels did not change with the administration of indomethacin, a cyclooxygenase inhibitor. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury.
Kawada
N
N
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Mizoguchi
Y
Y
Kobayashi
K
K
Yamamoto
S
S
Morisawa
S
S
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D016227:Benzoquinones; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D007213:Indomethacin; D015289:Leukotrienes / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors; D008099:Liver / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D011809:Quinones; D051381:Rats; D011919:Rats, Inbred Strains
D016227:Benzoquinones; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D011453:Prostaglandins; D011809:Quinones; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007213:Indomethacin