Dopexamine: studies in the general intensive care unit and after liver transplantation.
1. It has been suggested that the use of dopaminergic agents in the critically ill patient may reduce the incidence of renal failure and hence mortality. 2. Dopexamine hydrochloride is a new synthetic catecholamine. Like dopamine, it stimulates dopaminergic receptors. It also stimulates beta 2-adrenoceptors. Unlike dopamine, dopexamine has minimal effect at beta 1-adrenoceptors and no alpha-adrenoceptor activity. 3. Stimulation of renal dopaminergic and beta 2-adrenoceptors independently results in dilation of the renal vasculature. A natriuresis and diuresis is also promoted by dopaminergic stimulation. 4. A comparison between the administration of low dose dopamine and dopexamine in patients undergoing orthotopic liver transplantation resulted in less renal impairment and failure in the dopexamine group, although this did not achieve statistical significance. 5. Dopexamine elimination is reduced in the absence of hepatic function. 6. A patient with terminal liver failure was treated with dopexamine and although oxygen delivery was unchanged, oxygen consumption doubled. This suggests that dopexamine affects other organs as well as the kidneys.
Burns
A
A
John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge, UK.
Gray
P A
PA
Bodenham
A R
AR
Park
G R
GR
D003422:Critical Care; D004298:Dopamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000517:prevention & control; D008102:Liver Circulation / Q000187:drug effects; D016031:Liver Transplantation; D012079:Renal Circulation / Q000187:drug effects
C046318:dopexamine; D004298:Dopamine