Perfluorochemicals for gas transport and improvement of cell cultures.
This paper has considered the effects and potential application of PFCs, their emulsions and emulsion components for regulating growth and metabolic functions of microbial, animal and plant cells in culture. PFCs will help to overcome problems encountered in conventional culture systems (e.g. limited gas supply, mechanical damage), especially where cells are grown to high density. While the commercial potential of PFCs for in vitro systems has not yet been fully exploited, the most exciting areas for future developments are in the culture of animal and plant cell lines of importance in biotechnology and medicine.
King
A T
AT
Department of Zoology, University of Nottingham, UK.
Mulligan
B J
BJ
Lowe
K C
KC
D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005466:Fluorocarbons / Q000494:pharmacology*; D005740:Gases / Q000378:metabolism*; D059828:Plant Cells; D010944:Plants / Q000187:drug effects / Q000378:metabolism; D011060:Poloxalene / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism
D005466:Fluorocarbons; D005740:Gases; D011060:Poloxalene