[The antiradiation activity and mechanism of action of dimethylaminodithiazines].
A new group of radioprotective agents, dimethylaminodithiazines, was discovered. The agents are effective when used in relatively small amounts and exert a radioprotective effect rapidly with both intraperitoneal and per os injections. The role of inhibition of oxidative processes and DNA biosynthesis in the mechanism of radioprotective action of dimethylaminodithiazines is discussed.
Vladimirov
V G
VG
Strel'nikov
Iu E
IuE
Amosova
S V
SV
Gavrilova
G M
GM
Gostevskaia
V I
VI
Petrov
A S
AS
Sharova
L A
LA
D000818:Animals; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D011836:Radiation Tolerance / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D011837:Radiation-Protective Agents; D013843:Thiazines; D004247:DNA; D013890:Thiourea
Issledovanie protivoluchevoĭ aktivnosti i mekhanizm deĭstviia dimetilaminoditiazinov.