title: A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG).
abstract: The primary structure of a human mu heavy chain (DAG) protein is described. The native protein is a circular decamer with a molecular weight (Mr) of 500 kDa, each decamer being constituted of the constant domains C mu 2, C mu 3 and C mu4 and interlinked by 15 disulfide bridges. At its NH2-terminal each monomeric chain starts with an "extra sequence". The amino acid sequence of this segment is Arg-Gln-Ser-Asp-Asp-Pro-Val-Leu-Arg-Gly-Thr-Thr-Val-Pro-Val-Thr-Glu and its reinitiation point is located at Val223 (Gal numbering), at the beginning of C mu 2. This sequence has no homology with any other protein included in the present databases.
authors.affiliation: Laboratoire d'Immunochimie et d'Immunopathologie, U.108 INSERM, Hôpital Saint-Louis, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Mihaesco
authors.forename: P
authors.initials: P
authors.lastname: Ferrara
authors.forename: J C
authors.initials: JC
authors.lastname: Guillemot
authors.forename: N
authors.initials: N
authors.lastname: Congy
authors.forename: M C
authors.initials: MC
authors.lastname: Gendron
authors.forename: J P
authors.initials: JP
authors.lastname: Roy
authors.forename: P Y
authors.initials: PY
authors.lastname: Sizaret
authors.forename: E
authors.initials: E
authors.lastname: Mihaesco
mesh_terms: D000595:Amino Acid Sequence; D006362:Heavy Chain Disease / Q000235:genetics*; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007075:Immunoglobulin M / Q000235:genetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009154:Mutation
chemical_list: D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M