title: Enhanced in-vitro activity of liposome-trapped penicillin-G against Pseudomonas aeruginosa.
abstract: The growth inhibition of four Pseudomonas aeruginosa strains by liposome-trapped penicillin-G was investigated. There were indications of an association of the efficacy of liposomal penicillin-G with the nature of the 0-antigenic polymeric side chain. Namely, P28-800 and PCF-95 strains, characterized by a rough polysaccharide chain, were the most susceptible, whereas strain P28-0, possessing an intact lipopolysaccharide, resisted the activity of the entrapped drug. Among the rough strains, P642, a beta-lactamase producer, was not affected by the encapsulated drug. The composition of liposomes seems to have a significant impact in arresting the growth of the P. aeruginosa strain.
authors.affiliation: Department of Experimental Physiology, School of Health Sciences, Athens, Greece.
authors.forename: H
authors.initials: H
authors.lastname: Kotsifaki
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: G
authors.initials: G
authors.lastname: Panagiotidou
authors.forename: A C
authors.initials: AC
authors.lastname: Vatopoulos
authors.forename: C
authors.initials: C
authors.lastname: Economopoulou
authors.forename: N J
authors.initials: NJ
authors.lastname: Legakis
mesh_terms: D002118:Calcium / Q000494:pharmacology; D004337:Drug Carriers; D008070:Lipopolysaccharides / Q000378:metabolism; D008081:Liposomes; D010400:Penicillin G / Q000008:administration & dosage* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D008070:Lipopolysaccharides; D008081:Liposomes; C064821:beta-lactamase PSE-1; D001618:beta-Lactamases; D010400:Penicillin G; D002118:Calcium