Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion.
Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 60 and 430 ng/ml. Protein-stimulated acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 75 and 490 ng/ml. The mean pH of basal gastric secretions was 1.6 during placebo infusion and 4.6 when the mean plasma nizatidine concentration was 575 ng/ml.
Schneck
D W
DW
Lilly Laboratories for Clinical Research, Eli Lilly and Company, Indianapolis, IN.
Callaghan
J T
JT
Bergstrom
R F
RF
Obermeyer
B D
BD
Offen
W W
WW
D000328:Adult; D003864:Depression, Chemical; D004044:Dietary Proteins / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D016567:Nizatidine; D011897:Random Allocation; D012016:Reference Values; D013844:Thiazoles / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology
D004044:Dietary Proteins; D013844:Thiazoles; D016567:Nizatidine