title: Single-lumen vs double-lumen catheters for total parenteral nutrition. A randomized, prospective trial.
abstract: Multilumen catheters have been condemned for hyperalimentation based on reports of infection rates between 10% and 25% in uncontrolled studies. Because of the potential usefulness of multilumen catheters, we studied infection rates in a prospective, randomized trial. All patients requiring total parenteral nutrition were randomized to either single- or double-lumen catheters. Single-lumen catheters were used for dextrose-amino acids only. Medications or fat emulsions were given either by another central line or peripherally. Double-lumen catheters were used for dextrose-amino acid solutions, compatible medications, and fat emulsions. Catheters were cultured (48 single lumen and 53 double lumen) from 112 patients who successfully completed the study. No patients in either group developed catheter sepsis. We concluded that parenteral nutrition can be given as safely via double-lumen catheters as single-lumen catheters when strict protocols are established and followed.
authors.affiliation: Department of Veterans Affairs Medical Center, Long Beach, Calif.
authors.forename: B H
authors.initials: BH
authors.lastname: Johnson
authors.forename: E B
authors.initials: EB
authors.lastname: Rypins
mesh_terms: D001424:Bacterial Infections / Q000209:etiology; D002408:Catheters, Indwelling; D015986:Confounding Factors, Epidemiologic; D006801:Humans; D010289:Parenteral Nutrition, Total / Q000009:adverse effects / Q000295:instrumentation*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic