title: Bupropion: new therapy for depression.
abstract: Bupropion is one of the most recently approved antidepressant drugs. The drug differs in chemical structure from the tricyclic antidepressants. It mechanism of action is unknown. Bupropion weakly blocks dopamine uptake, but this property does not seem to account for the antidepressant effects. In clinical trials, bupropion has shown satisfactory antidepressant action compared with placebo. Because long-term effects are not well established, bupropion should be discontinued after several months of therapy.
authors.affiliation: Hahnemann University School of Medicine, Philadelphia, Pennsylvania.
authors.forename: M
authors.initials: M
authors.lastname: Feinberg
mesh_terms: D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016642:Bupropion; D003863:Depression / Q000188:drug therapy; D006801:Humans; D011427:Propiophenones / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion