title: [Mechanisms of exertion dyspnea in cardiac insufficiency].
abstract: Effort dyspnea in cardiac failure corresponds to a subjective perception of difficulty in breathing which is itself secondary to a disproportion between the central bulbar respiratory regulation and the level of pulmonary ventilation attained. In cardiac failure, this situation is the result of dysfunction of both the respiratory apparatus and the skeletal striated muscle during exercise. During exercise a rise in left ventricular end diastolic pressure causes: a reduction in pulmonary compliance. The bronchial and alveolar capillaries drain into the pulmonary veins. The congestion of these capillaries and the resulting oedema makes the lung "stiffer"; an increase in the resistances of the small airways due to direct compression by congested bronchial vessels. The physiological dead space increases: the respiratory muscles ventilate pulmonary zones which are not perfused to no benefit. The reduction of pulmonary compliance, the increased resistances of the airways and of the physiological dead space all contribute to increase the work of the respiratory muscles. In addition to these mechanical phenomena, there is greater stimulation of the respiratory centre in the brain stem by the metabolic abnormalities of the skeletal striated muscles. During effort, they rapidly function under anaerobic conditions and the resulting hyperproduction of lactate and carbon dioxide stimulates the respiratory centres.
authors.affiliation: Service des maladies cardio-vasculaires et service d'exploration fonctionnelle, hôpital Cochin, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Cabanes
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
mesh_terms: D015308:Anaerobic Threshold; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology*; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D005082:Physical Exertion; D012119:Respiration; D012125:Respiratory Center / Q000503:physiopathology
vernacular_title: Mécanismes de la dyspnée d'effort de l'insuffisance cardiaque.