title: MR and CT of tuberous sclerosis: linear abnormalities in the cerebral white matter.
abstract: A review of MR and CT images in five patients, 8 months to 22 years old, diagnosed as having tuberous sclerosis, revealed linear abnormalities in the cerebral white matter. A linear abnormality connecting a subependymal nodule to a subcortical lesion was shown in two patients as an area of hypointensity on T1-weighted MR images and as an area of hyperintensity on T2-weighted images. These appeared as faintly high-density areas on CT images. Seventeen linear abnormalities extending from the ventricle to the cortex with a subependymal nodule or subcortical lesion on each end were visible in all five patients as areas of hyperintensity on the T2-weighted images. On the T1-weighted images, only nine hypointense lines were noted. CT scans did not show these latter lines. Linear abnormalities in cerebral white matter are suggestive of lesions of demyelination, dysmyelination, hypomyelination, or lines of migration disorder. MR imaging, especially T2-weighted, is particularly sensitive in detecting these abnormalities.
authors.affiliation: Department of Radiology, Nara Medical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Kichikawa
authors.forename: A
authors.initials: A
authors.lastname: Fukusumi
authors.forename: Y
authors.initials: Y
authors.lastname: Watabe
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: H
authors.initials: H
authors.lastname: Otsuji
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: H
authors.initials: H
authors.lastname: Uchida
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology*