title: [Clinical pharmacologic study of Tri-Regol tablets (new oral triphase contraceptives)].
abstract: Clinical pharmacological investigations have been carried out with the new oral triphase contraceptive, Tri-RegolR. It has been established that pregnancy had not occurred during 235 cycles of 59 patients. Treatment had to be discontinued in two cases because of side effects which might have been caused by the preparation. Subjective and objective side effects occurred in 24 (10.2%) cases. During treatment with Tri-RegolR tablets proteo and steroid hormones--except prolactin--significantly decreased that phenomenon is characteristic of anovular cycle. Among patients that had previously prolonged treatment with Anteovin tablets did not occur hyperprolactinemia. Infertility would not be expected from prolonged administration of the preparation. From relative decrease of serum progesterone levels during treatment with the three preparations conclusion was drawn that the preparations did not prevent physiological conversion of endometrium.
authors.affiliation: Heves Megyei Tanács Kórház-Rendelöintézet, Szülészet-nögyógyászati osztály.
authors.forename: M
authors.initials: M
authors.lastname: Farkas
authors.forename: L
authors.initials: L
authors.lastname: Kovács
authors.forename: E
authors.initials: E
authors.lastname: Tasiné Tóth
mesh_terms: D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D003278:Contraceptives, Oral, Hormonal; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000009:adverse effects; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D009644:Norgestrel / Q000009:adverse effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
chemical_list: D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: A TRI-REGOL tabletta klinikai- farmakológiai vizsgálata (Uj, orális, trifázisos kontraceptivum).