title: [Report of five cases of major surgery during anticoagulant therapy after prosthetic valve replacement].
abstract: The major surgery for gastroduodenal ulcer, gastric cancer, esophageal cancer, and mediastinal tumor, were performed on 5 patients during anticoagulant therapy after prosthetic valve replacement. In the postoperative management, Dipyridamole (30 mg/day) was given in case 1, Heparin sodium (24,000 mu/day) in case 2, 3, and Gabexate Mesilate in case 4, 5. Postoperative course was uneventful in case 1, 3, 4, 5, intratracheal bleeding was recognized on the 3rd postoperative day and treated by reducing of heparin dose in case 2. Gabexate Mesilate was thought to be effective and free from complication in case 4, 5.
authors.affiliation: Department of Cardiovascular Surgery, Fukushima Medical College.
authors.forename: H
authors.initials: H
authors.lastname: Midorikawa
authors.forename: F
authors.initials: F
authors.lastname: Iwatani
authors.forename: T
authors.initials: T
authors.lastname: Igari
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Hagiwara
authors.forename: M
authors.initials: M
authors.lastname: Tanji
authors.forename: H
authors.initials: H
authors.lastname: Sadogawa
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Hoshino
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D004176:Dipyridamole / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D016670:Gabexate; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D009369:Neoplasms / Q000601:surgery*; D010437:Peptic Ulcer / Q000601:surgery*; D011182:Postoperative Care
chemical_list: D000925:Anticoagulants; D006146:Guanidines; D016670:Gabexate; D004176:Dipyridamole; D006493:Heparin