[Inhibition of rat heart and kidney allograft rejection by photochemical treatment of the recipient].
After temporary posttransplant PUVA treatment of graft recipients the survival time of rat heart and kidney allografts was significantly prolonged. In the semiallogeneic F1 model all kidney transplant recipients survived without rejection signs. The mechanism of action should be cleared especially the role of cis-urocanic acid and the introduction of the method into clinical organ transplantation is discussed.
Oesterwitz
H
H
Urologische Klinik, Krankenhauses im Friedrichshain.
Gruner
S
S
Schneider
W
W
D000818:Animals; D006084:Graft Rejection / Q000187:drug effects* / Q000528:radiation effects; D006085:Graft Survival / Q000187:drug effects* / Q000528:radiation effects; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008730:Methoxsalen / Q000627:therapeutic use*; D009336:Necrosis; D010778:Photochemotherapy; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous; D014466:Ultraviolet Rays
D008730:Methoxsalen
Beeinflussung der Abstossungsreaktion allogener Rattenherz- und Nierentransplantate durch eine photochemische Empfängerbehandlung.