[The inhibiting effect of ortofen and dexamethasone on the development of tumors of the cervix uteri and vagina].
The effects of nonsteroidal and steroidal drugs ortophen and dexamethasone on carcinogenesis of the uterine cervix and vagina were studied on mice. Intravaginal applications of a 0.1% solution of 7,12-dimethylbenz(a)anthracene, 2 times a week for 8 weeks, induced cervical and vaginal carcinomas in 67% of cases in 35 weeks. Ortophen (20 mg/l of drinking water) and dexamethasone (1 mg/kg of feed) used on completion of carcinogen effect decreased the incidence of cervical and vaginal carcinomas and diminished mortality of the tumors.
Bespalov
V G
VG
Aleksandrov
V A
VA
Troian
D N
DN
Lidak
M Iu
MIu
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004008:Diclofenac; D015127:9,10-Dimethyl-1,2-benzanthracene; D003907:Dexamethasone
Tormoziashchiĭ éffekt ortofena i deksametazona na razvitie éksperimental'nykh opukholeĭ sheĭki matki i vlagalishcha.