title: After the epidemic: follow up study of HIV seroprevalence and changing patterns of drug use.
abstract: OBJECTIVE
  To follow up known intravenous drug users to determine current health state and drug use, compare characteristics with those of recent drug users, and examine HIV exposure and serostate.
  
  
  METHODS
  Subjects were identified from conventional general practice records and recruited from 1980 to the end of 1985; they were followed up during 1987 and 1988 and compared with drug users identified in the same way but recruited after 1985.
  
  
  METHODS
  General practice and community in north west Edinburgh. Follow up conducted throughout the United Kingdom.
  
  
  METHODS
  Subjects known to have injected illegal drugs before 1986 (n = 203) and since that time.
  
  
  METHODS
  Mortality from and prevalence of HIV seropositivity and various parameters indicative of abstinence.
  
  
  RESULTS
  Of the 203 subjects in the follow up group, 189 (93%) were traced; 16 (8%) had died and the remaining 173 (85%) were interviewed. In all, 146 (72% of the follow up cohort) had been tested for HIV antibodies, 94 (64%) having positive and 52 (36%) negative results; 57 (28%) had not been tested. Of the 65 subjects in the recently recruited group, 51 (79%) had been tested for HIV, 15 (29%) having positive results. A further 21 (43%) were currently negative for HIV antibody but still at risk. Thirty three (19%) of those followed up were confirmed abstinent, although more (about half) showed evidence of diminished drug injecting. Age correlated strongly with abstinence (p less than 0.001). One third of the group currently used cannabis, buprenorphine, dihydrocodeine, or diazepam. When the two groups were analysed together there was a strong association between the date of starting injecting and HIV seropositivity (chi 3 = 23.81, df = 2, p less than 0.001), with a peak around 1980-3.
  
  
  CONCLUSIONS
  Although only a fifth of the followed up group were convincingly abstinent, a much larger group showed evidence of prolonged periods of remission. Overall, much use of oral drugs was confirmed and worrying trends towards taking buprenorphine and benzodiazepines were evident. The peak incidence of starting drug use and the comparatively low seroprevalence of HIV in the newer drug users probably explain the anomalous high seroprevalence in Edinburgh drug users during 1980-5. The epidemic of HIV during the first half of the 1980s in the group suggests that the virus was probably being transmitted because of a pattern of behaviour. Changing patterns of HIV transmission suggest a need to concentrate on heterosexual transmission as the main problem in the future.
authors.affiliation: Edinburgh Drug Addiction Study, Muirhouse Medical Group, Edinburgh.
authors.forename: C A
authors.initials: CA
authors.lastname: Skidmore
authors.forename: J R
authors.initials: JR
authors.lastname: Robertson
authors.forename: A A
authors.initials: AA
authors.lastname: Robertson
authors.forename: R A
authors.initials: RA
authors.lastname: Elton
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000635:transmission; D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D015528:HIV Seroprevalence / Q000639:trends; D006304:Health Status; D006801:Humans; D008297:Male; D011446:Prospective Studies; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000453:epidemiology*; D019966:Substance-Related Disorders / Q000150:complications; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology