title: [Gene rearrangement in leukemia].
abstract: In this report we summarize our experiences based on the gene rearrangement study of 111 leukaemic patients of different kind. The lymphocyte DNA of the patients was studied for rearrangement of the immunoglobulin light chain constant-, the heavy chain joining- and the T cell receptor beta chain constant region. Our data have well supplemented the results of the monoclonal antibody experiments. In 33 cases the DNA study was in good agreement with the immunological data. In 42 our data helped in gave different results, immunological results. In 11 cases evaluating the DNA and immunological data indicating the necessity of further investigation. The results were inconclusive in 25 cases. As a conclusion we consider the gene rearrangement study to be useful for diagnostic purposes.
authors.affiliation: Országos Haematológiai és Vértranszfúziós Intézet, Budapest.
authors.forename: J
authors.initials: J
authors.lastname: Földi
authors.forename: G
authors.initials: G
authors.lastname: Kardos
authors.forename: A
authors.initials: A
authors.lastname: Király
authors.forename: M
authors.initials: M
authors.lastname: Magyar
authors.forename: A
authors.initials: A
authors.lastname: Mód
authors.forename: K
authors.initials: K
authors.lastname: Pálóczi
authors.forename: A
authors.initials: A
authors.lastname: Poros
authors.forename: T
authors.initials: T
authors.lastname: Révész
authors.forename: G
authors.initials: G
authors.lastname: Szandtner
authors.forename: J
authors.initials: J
authors.lastname: Szelényi
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002648:Child; D004247:DNA / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D007147:Immunoglobulin Light Chains / Q000276:immunology; D007938:Leukemia / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D004247:DNA
vernacular_title: Génátrendezödés leukaemiákban.