title: Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 51Cr-EDTA clearance, creatinine clearance, serum creatinine and beta 2 microglobulin.
abstract: Glomerular filtration rates (GFR) were measured with 51Cr-EDTA in 38 patients (aged 40-75 years) with homozygous sickle cell disease and compared with serum beta 2 microglobulin concentrations in 38 patients and with creatinine clearance in 21 patients. GFR estimated with 51Cr-EDTA was closely correlated with single serum creatinine measurements and the inverse of serum beta 2 microglobulin. Creatinine clearance was also found to be correlated, but values were, on average, 32% below those obtained by the 51Cr-EDTA method, and this difference was significant. It is concluded that measurements of beta 2 microglobulin, single serum creatinine, and creatinine clearance are valuable indicators of GFR in homozygous sickle cell disease. Measurement of beta 2 microglobulin was a useful and reliable method of estimating GFR from single plasma measurements and is therefore a useful means of screening the population.
authors.affiliation: Department of Nuclear Medicine, John Radcliffe Hospital, Oxford.
authors.forename: S A
authors.initials: SA
authors.lastname: Aparicio
authors.forename: S
authors.initials: S
authors.lastname: Mojiminiyi
authors.forename: J D
authors.initials: JD
authors.lastname: Kay
authors.forename: B J
authors.initials: BJ
authors.lastname: Shepstone
authors.forename: K
authors.initials: K
authors.lastname: de Ceulaer
authors.forename: G R
authors.initials: GR
authors.lastname: Serjeant
mesh_terms: D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000503:physiopathology*; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D004492:Edetic Acid / Q000378:metabolism; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008657:Metabolic Clearance Rate; D008722:Methods; D008875:Middle Aged; D012805:Sickle Cell Trait / Q000378:metabolism / Q000503:physiopathology*; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D002860:Chromium Radioisotopes; D001613:beta 2-Microglobulin; D004492:Edetic Acid; D003404:Creatinine