Receptors for transferrin in pathogenic bacteria are specific for the host's protein.
Transferrin receptors detected by a solid-phase binding assay were shown to be specific for the host's transferrin in the representative bacterial pathogens Neisseria meningitidis (human), Pasteurella haemolytica (bovine), and Actinobacillus pleuropneumoniae (porcine). Consistent with the receptor specificity, iron-deficient bacteria were only capable of utilizing transferrin from the host as a source of iron for growth.
Schryvers
A B
AB
Department of Microbiology and Infectious Diseases, University of Calgary, Alta, Canada.
Gonzalez
G C
GC
D000188:Actinobacillus / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D000818:Animals; D002417:Cattle; D006801:Humans; D009345:Neisseria meningitidis / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D010325:Pasteurella / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D011990:Receptors, Transferrin / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine; D014168:Transferrin / Q000378:metabolism*
D011990:Receptors, Transferrin; D014168:Transferrin