Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.
Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.
Sugawara
K
K
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Hatori
M
M
Nishiyama
Y
Y
Tomita
K
K
Kamei
H
H
Konishi
M
M
Oki
T
T
D000577:Amides / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005285:Fermentation; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012694:Serine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000577:Amides; D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; C063282:eponemycin; D012694:Serine