[Antitumor effectiveness and nephrotoxicity of oxoplatinum].
Studies on such transplantable murine tumors as MOPC-21 plasmacytoma and Krebs-2 carcinoma showed oxoplatinum course administration to produce necrosis in solid tumors and pronounced alterations in surviving tumor cells. Single applications of 15 or 20 mg/kg were followed by an increase in the mean survival of Krebs-2 ascites carcinoma--bearing mice by one half. Oxoplatinum--induced changes in the renal tissue ranged from moderate under continuous administration to acute renal failure after high--dose treatment. Such diuretics as diacarb, furosemide and, particularly, mannitol did not interfere with oxoplatinum activity against solid and ascites tumors but assured less pronounced structural disorders in the kidney as compared to oxoplatinum alone.
Aref'eva
A K
AK
Rykov
V A
VA
Mitrokhina
L N
LN
D000086:Acetazolamide / Q000008:administration & dosage; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008353:Mannitol / Q000008:administration & dosage; D051379:Mice; D010954:Plasmacytoma / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents; D008353:Mannitol; D005665:Furosemide; D000086:Acetazolamide; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV
Protivoopukholevaia éffektivnost' i nefrotoksichnost' oksoplatiny.