Effect of ultrasound monitoring of follicular growth on the conception rate. A clinical study.
Periovulatory ultrasonography (POUS) was performed on 59 anovulatory women over 523 treatment cycles. Follicular development was stimulated with either clomiphene citrate (CC) or human menopausal gonadotropin (hMG). Thirty-one pregnancies were induced; 23 went to term. Three factors were considered in evaluating the incidence of conception: the patient's age, drug use and the presence or absence of POUS. There was no evidence that the pregnancy rate after POUS differed from that without it (estimated conception rate ratio = 1.2:1, P = .76). Similarly, conceptus viability was not demonstrably different whether POUS was used or not (P = 1.00). However, the data show a strong advantage of hMG over CC in achieving conception (estimated conception rate ratio = 5.85, P less than .0001) and no disadvantage in conceptus viability (P = 1.00). The data also suggest that in women less than 30 years of age with polycystic ovaries, ovulation induction is easier to achieve and the conception rate higher than in older women. There was no evidence that POUS decreased the conception rate or increased fetal wastage.
Abdul-Karin
R W
RW
Department of Obstetrics and Gynecology, State University of New York Health Science Center, Syracuse 13210.
Terry
F M
FM
Badawy
S Z
SZ
Sheehe
P R
PR
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005306:Fertilization; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D014463:Ultrasonography / Q000009:adverse effects*
D002996:Clomiphene; D008596:Menotropins