Effect of adrenalectomy and demedullation on the stress-induced impairment of long-term potentiation.
In these three experiments, we investigated the effect of adrenalectomy and adrenal demedullation on the stress-induced impairment of long-term potentiation (LTP) in the rat hippocampal slice. In the first, adrenalectomy alone resulted in a significant reduction in LTP, while exposure to stress resulted in a further reduction. In the second, replacing corticosterone in adrenalectomized rats did not restore LTP. In the last experiment, demedullation resulted in a reduction in LTP similar to that induced by adrenalectomy, while exposure to stress did not result in a further reduction. In combination, these studies provide evidence that the adrenal medullary system modulates hippocampal plasticity and the stress-induced impairment of LTP.
Shors
T J
TJ
University of Southern California, Department of Psychology, Los Angeles.
Levine
S
S
Thompson
R F
RF
D000311:Adrenal Glands / Q000502:physiology*; D000313:Adrenal Medulla / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000502:physiology; D004558:Electric Stimulation; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*
D003345:Corticosterone