Antimetastatic and growth-inhibitory effects of N-acetylchitohexaose in mice bearing Lewis lung carcinoma.
N-Acetylchitohexaose, a water-soluble oligosaccharide was found to display a significant antimetastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40-50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after the tumor implantation (5 x 10(5) cells/mouse). It was also revealed that this hexaose had a significant growth-inhibitory effect against the local tumor of the same carcinoma (a 20-30% inhibition ratio), showing an enhancing effect on concomitant immunity in local tumor-resected mice. This oligosaccharide was also shown to enhance the tumoricidal effect of splenic T lymphocytes against LLC and P-815 mastocytoma cells and to increase the natural killer activity of splenic T lymphocytes, assayed with YAC-1 cells as the target.
Tsukada
K
K
Department of Microbiology, Tohoku College of Pharmacy, Miyagi.
Matsumoto
T
T
Aizawa
K
K
Tokoro
A
A
Naruse
R
R
Suzuki
S
S
Suzuki
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000276:immunology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009368:Neoplasm Transplantation; D009844:Oligosaccharides / Q000627:therapeutic use*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000970:Antineoplastic Agents; D009844:Oligosaccharides; C056529:N-acetylchitohexaose