title: Interethnic genetic differentiation: GM polymorphism in eastern Senegal.
abstract: Analysis of GM polymorphism has been performed on 1,806 individuals representing three sympatric ethnic groups--Bedik, Fulani, and Mandenkalu--of eastern Senegal. Haplotype frequencies estimated by maximum likelihood have been used to compute common genetic pools between the three samples and a number of other sub-Saharan African populations. Despite extreme linguistic and sociocultural differentiations and very high levels of endogamy, especially in the Bedik and Niokholo Mandenkalu, the three populations share about 90%-95% of their haplotype frequencies in a system which commonly provides strong genetic differentiations. This supports the view that, despite its importance at a large continental scale level, as it is discussed for a set of populations from many regions of sub-Saharan Africa, sociocultural differentiation usually has little effect on local genetic diversity.
authors.affiliation: Centre d'Hémotypologie du C.N.S.R., Hôpital Purpan, Toulouse.
authors.forename: M
authors.initials: M
authors.lastname: Blanc
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Mazas
authors.forename: N H
authors.initials: NH
authors.lastname: Van Blyenburgh
authors.forename: A
authors.initials: A
authors.lastname: Sevin
authors.forename: G
authors.initials: G
authors.lastname: Pison
authors.forename: A
authors.initials: A
authors.lastname: Langaney
mesh_terms: D003710:Demography; D005006:Ethnicity; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D011336:Probability; D012675:Senegal
chemical_list: D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains