Immunocytochemistry of the cell nucleus.
This electron microscopic review addresses in situ immunocytochemistry of the mammalian cell nucleus with special reference to the use of autoantibodies, which are the major source of antinuclear antibodies. The localization of many key nuclear antigens is documented and immunocytochemical data are related to the major functional processes of transcription and processing of RNA and to replication of DNA.
Raska
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W. M. Keck Autoimmune Disease Center, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Ochs
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Salamin-Michel
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D000818:Animals; D000974:Antibodies, Antinuclear; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure*; D004247:DNA / Q000648:ultrastructure; D006801:Humans; D016253:Microscopy, Immunoelectron; D012261:Ribonucleoproteins / Q000648:ultrastructure
D000974:Antibodies, Antinuclear; D012261:Ribonucleoproteins; D004247:DNA