Frequency of light chain deposition nephropathy relative to renal amyloidosis and Bence Jones cast nephropathy in a necropsy study of patients with myeloma.
The frequency of light chain deposition nephropathy relative to renal amyloidosis and Bence Jones cast nephropathy was determined in a necropsy study of 57 patients with myeloma. The diagnosis of light chain deposition nephropathy was established by immunofluorescence microscopic examination of kidney tissue demonstrating linear deposits of a single light chain isotype along tubular and other renal basement membranes, and by electron microscopy, which showed the characteristic granular nature of the deposits. In this study, 3 patients (5%) had kappa light chain deposition nephropathy, 6 (11%) had renal amyloidosis, and 18 (32%) had Bence Jones cast nephropathy. The data indicate that light chain deposition nephropathy is a rare complication of multiple myeloma.
Iványi
B
B
Department of Pathology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D001536:Bence Jones Protein; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007668:Kidney / Q000276:immunology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000276:immunology*; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence / Q000379:methods; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology*
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D001536:Bence Jones Protein