title: Hypofibrinolysis associated with vasculopathy in non insulin dependent diabetes mellitus.
abstract: The pathogenesis of diabetic vasculopathy has been related to modifications in hemostasis and fibrinolysis. 50 non insulin dependent diabetes mellitus patients have been studied. Euglobulin clot lysis time, fibrin plate, tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PAI) activity, Protein C and S, cholesterol, triglycerides and Hb A1c were determined in blood samples. Diabetic patients showed decreased fibrinolytic activity, as measured by ECLT, with clearly increased PAI levels. Fibrinolytic response to venous occlusion was lower than normal. Vascular complications were associated both with an even higher PAI activity and with a decreased fibrinolytic response to venous occlusion. Elevated PAI activity and decreased fibrinolytic response to stimulus may contribute to vascular disease in diabetes.
authors.affiliation: Haematology Department, Ramon y Cajal Hospital, Madrid, Spain.
authors.forename: L J
authors.initials: LJ
authors.lastname: García Frade
authors.forename: H
authors.initials: H
authors.lastname: de la Calle
authors.forename: M C
authors.initials: MC
authors.lastname: Torrado
authors.forename: J I
authors.initials: JI
authors.lastname: Lara
authors.forename: L
authors.initials: L
authors.lastname: Cuellar
authors.forename: A
authors.initials: A
authors.lastname: García Avello
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator