Endocrine profile associated with estrogen and progesterone receptors in leiomyoma and normal myometrium.
In leiomyoma and normal myometrium estrogen receptors act independently at low or high levels of the normal serum steroid range in the menstrual cycle. It might be an inherent characteristic of leiomyomas, which results in their progressive growth in the absence of any abnormal stimulation. In the secretory phase of the menstrual cycle, serum progesterone suppresses estrogen receptor concentrations in leiomyoma. In the present study serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) showed direct as well as inverse correlations with estrogen and progesterone receptors in different phases of the menstrual cycle.
Sadan
O
O
Department of Obstetrics and Gynecology, Sackler Faculty of Medicine, Tel Aviv University at the Edith Wolfson Medical Center, Holon, Israel.
van Iddekinge
B
B
Savage
N
N
van der Walt
L A
LA
Zakut
H
H
D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007889:Leiomyoma / Q000032:analysis* / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D009215:Myometrium / Q000032:analysis*; D011374:Progesterone / Q000097:blood; D011959:Receptors, Estradiol / Q000032:analysis* / Q000502:physiology; D011980:Receptors, Progesterone / Q000032:analysis* / Q000502:physiology; D014594:Uterine Neoplasms / Q000032:analysis* / Q000503:physiopathology
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone