title: Nutrient and nonnutrient renal blood flow.
abstract: The role of prostaglandins in the distribution of total renal blood flow (TRBF) between nutrient and nonnutrient compartments was investigated in anesthetized mongrel dogs. Renal blood flow distribution was assessed by the xenon 133 freeze-dissection technique and by rubidium 86 extraction after ibuprofen treatment. Ibuprofen (13 mg/kg) significantly decreased TRBF by 16.3% +/- 1.2% (mean +/- SEM electromagnetic flow probe; p less than 0.005), but did not alter blood flows to the outer cortex (3.7 vs 4.3 ml/min per gram), the inner cortex (2.6 vs 2.7 ml/min per gram), and the other medulla (1.5 vs 1.5 ml/min per gram), which suggests a decrease in nonnutrient flow. In a separate group of animals the effect of reduced blood flow on the nutrient and nonnutrient components was determined by mechanically reducing renal arterial blood flow by 48%. Unlike the ibuprofen group, nutrient blood flows were proportionally reduced with the mechanical decrease in TRBF in the outer cortex (1.9 ml/min per gram, p less than 0.05), the inner cortex (1.4 ml/min per gram, p less than 0.05), and the outer medulla (0.8 ml/min per gram, p less than 0.01). These results indicate no shift between nutrient and nonnutrient compartments. Nutrient and nonnutrient renal blood flows of the left kidney were also determined by 86Rb extraction. After ibuprofen treatment, nonextracted 86Rb decreased to 12.1% from the control value of 15.6% (p less than 0.05). Mechanical reduction of TRBF did not significantly decrease the proportion of unextracted 86Rb (18.7%).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40292.
authors.forename: J S
authors.initials: JS
authors.lastname: Young
authors.forename: J C
authors.initials: JC
authors.lastname: Passmore
authors.forename: D A
authors.initials: DA
authors.lastname: Hartupee
authors.forename: C H
authors.initials: CH
authors.lastname: Baker
mesh_terms: D000818:Animals; D002860:Chromium Radioisotopes; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D015777:Eicosanoids / Q000378:metabolism*; D004912:Erythrocytes; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D007672:Kidney Cortex / Q000098:blood supply; D007679:Kidney Medulla / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects; D012414:Rubidium Radioisotopes; D014980:Xenon Radioisotopes
chemical_list: D002860:Chromium Radioisotopes; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D012414:Rubidium Radioisotopes; D014980:Xenon Radioisotopes; D007052:Ibuprofen