Prostaglandins and the dog stomach: effects of misoprostol on the proportion of mucosa to muscle and on the proportion of different epithelial cell types.
Dogs were given an oral dose of 300 micrograms/kg/day of the prostaglandin E1 analogue, misoprostol for 11 weeks. The relative areas of the main components of the fundus and antrum per unit area of serosa were quantified. While the volume occupied by the muscle layers did not change, there was an increase in mucosal volume in both sites. The relative volume fraction of the main mucosal cell types was then determined by a point counting technique. Misoprostol very highly significantly increased the fraction of mucosal volume occupied by surface mucus cells, and also significantly decreased the volume fraction of the parietal cells.
Goodlad
R A
RA
Imperial Cancer Research Fund, Histopathology Unit, London, UK.
Madgwick
A J
AJ
Moffatt
M R
MR
Levin
S
S
Allen
J L
JL
Wright
N A
NA
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002452:Cell Count / Q000187:drug effects; D004285:Dogs; D005088:Exocrine Glands / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D016595:Misoprostol; D009093:Mucus; D010295:Parietal Cells, Gastric / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D016595:Misoprostol; D000527:Alprostadil