Double-blind, placebo-controlled, multi-centre trial of the efficacy and tolerance of niflumic acid ('Nifluril') capsules in the treatment of tonsillitis in adults.
A double-blind, placebo-controlled study was carried out in 231 adult patients suffering from acute diffuse pharyngitis or acute tonsillitis with fever and dysphagia to assess the effectiveness of niflumic acid combined with standard antibiotic therapy in relieving pain and inflammation. Patients were allocated at random to receive either 4 capsules of 250 mg niflumic acid or placebo daily in addition to 1.5 million units phenoxymethyl penicillin for 4 to 5 days. Clinical assessments before and after 2 and 4 days of treatment showed that there was faster resolution of fever, pain, adenopathy, pharyngeal congestion and dysphagia, and improved patient comfort in the niflumic acid group. Few side-effects were recorded and there were only 4 drop-outs due to side-effects in patients receiving niflumic acid.
Sauvage
J P
JP
Hôpital Dupuytren, Service ORL, Limoges, France.
Ditisheim
A
A
Bessede
J P
JP
David
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D003680:Deglutition Disorders / Q000145:classification / Q000188:drug therapy / Q000209:etiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009539:Nicotinic Acids / Q000627:therapeutic use*; D009544:Niflumic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010404:Penicillin V / Q000627:therapeutic use*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D014069:Tonsillitis / Q000150:complications / Q000188:drug therapy*
D009539:Nicotinic Acids; D010919:Placebos; D009544:Niflumic Acid; D010404:Penicillin V