[New heterocyclic systems for thiophene-2-thiolates--synthesis and biological activity].
Dicyanketendithiolae reacts with equimolar amounts of halogenmethans, substituted with electron withdrawing groups, to give thiophene-2-thiolates. These compounds are used for the preparation of thieno[2,3-b]thiophenes, including several functional groups in 2- and 5-position. Anellation of 1,3-oxazin-, pyrimidin-, 1,2,3-triazin- or 1,4-oxazepin-cycles give hitherto unknown tri- and tetracyclic ring systems. Some of synthetised compounds show biological activity.
Briel
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Sektion Biowissenschaften der Universität Leipzig.
D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D002470:Cell Survival / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006967:Hypersensitivity / Q000517:prevention & control; D010077:Oxazepines / Q000138:chemical synthesis / Q000494:pharmacology; D010078:Oxazines / Q000138:chemical synthesis / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; D006571:Heterocyclic Compounds; D010077:Oxazepines; D010078:Oxazines; D011743:Pyrimidines; D013876:Thiophenes; D014227:Triazines
Neue Heterocyclensysteme aus Thiophen-2-thiolen--Synthese und biologische Aktivität.