[Massive delayed-action verapamil poisoning].
An 18-year old woman developed cardiogenic shock after ingestion of 16.8 g of a sustained release form of verapamil. Severe left ventricular diastolic dysfunction was demonstrated. For the first time muscular involvement was observed with myalgia and elevation of the MM isoenzyme of creatinine kinase. The efficacy isoproterenol and the need for prolonged treatment are emphasised.
Hagège
A
A
Service de cardiologie, hôpital Boucicaut, Paris.
Masquet
C
C
Beaufils
P
P
Slama
R
R
D000293:Adolescent; D002304:Cardiac Pacing, Artificial; D003402:Creatine Kinase / Q000097:blood; D003692:Delayed-Action Preparations; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use; D009135:Muscular Diseases / Q000139:chemically induced; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000628:therapy; D016277:Ventricular Function, Left / Q000187:drug effects; D014700:Verapamil / Q000097:blood / Q000506:poisoning*
D003692:Delayed-Action Preparations; D014700:Verapamil; D003402:Creatine Kinase; D007545:Isoproterenol
Intoxication massive par le vérapamil à libération prolongée.