title: Selective chemoprophylaxis guided by multifactorial analysis in superficial bladder cancer.
abstract: One hundred and five patients with superficial bladder cancer (60 primary and 45 recurrent tumors) entered a prospective chemoprophylaxis trial after transurethral resection of the tumor. The drug for chemoprophylaxis was chosen by a computer which received the tumor data and analyzed them through a previous program of recurrence risk factors (multivariant analysis). In comparison with the aleatory selection of the drug, this statistical computerized choice has diminished the recurrence index (from 8 to 3) and increased the interval free of disease (from 70 to 83.5 months) in this group of patients.
authors.affiliation: Service of Urology, La Fe Hospital, Valencia, Spain.
authors.forename: C D
authors.initials: CD
authors.lastname: Vera-Donoso
authors.forename: B
authors.initials: B
authors.lastname: Llopis
authors.forename: F
authors.initials: F
authors.lastname: Oliver
authors.forename: J
authors.initials: J
authors.lastname: Gallego
authors.forename: J
authors.initials: J
authors.lastname: Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez Cruz
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D004360:Drug Therapy, Computer-Assisted; D006801:Humans; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors; D013813:Therapy, Computer-Assisted; D013852:Thiotepa / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D013852:Thiotepa; D002945:Cisplatin