[Synthesis and analgesic activity of the derivatives of 3-methyl fentanyl].
Six analogues of 1-substituted-3-methylfentanyl were synthesized. All of them are liquid compounds. Preliminary pharmacological results showed that some compounds of 1-beta-substituted vinylethyl-3-methyl derivatives of fentanyl have strong analgesic activity with typical morphine-like action.
Zhu
G Z
GZ
Institute of Pharmaceutical Chemistry, PLA, Beijing.
Li
Y
Y
Yan
S M
SM
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship
D000700:Analgesics; C030592:3-methylfentanyl; D005283:Fentanyl