title: Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs.
abstract: The influence of 22 flavonoids was studied on the arachidonic acid metabolism in sonicated sheep platelets. Flavones and flavonols possessing catechol groups inhibited 12-lipoxygenase. Sideritoflavone and quercetagetin-7-O-beta-D-glucoside were more selective than quercetin. Cirsiliol, hypolaetin, hypolaetin-8-O-beta-D-glucoside, gossypetin, gossypin, hibifolin and leucocyanidol were also 12-lipoxygenase inhibitors with some differences in potency and selectivity. Xanthomicrol was a weak cyclooxygenase inhibitor. These results suggest that lipoxygenase inhibition can play a role in the anti-inflammatory activity of hypolaetin-8-O-beta-D-glucoside, sideritoflavone, gossypin and hibifolin. On the other hand, the presence of sideritoflavone, hypolaetin-8-O-beta-D-glucoside, cirsiliol and xanthomicrol in several species of Sideritis may provide a basis for the use of such plants as anti-inflammatory agents.
authors.affiliation: Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Valencia, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Ferrándiz
authors.forename: A G
authors.initials: AG
authors.lastname: Nair
authors.forename: M J
authors.initials: MJ
authors.lastname: Alcaraz
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005419:Flavonoids / Q000494:pharmacology*; D007194:India; D010946:Plants, Medicinal / Q000032:analysis*; D012756:Sheep; D013030:Spain
chemical_list: D001095:Arachidonic Acids; D005419:Flavonoids; D016718:Arachidonic Acid