Periodic histopathological and ultrastructural changes of excess vitamin A on oral carcinogenesis.
In this study initially a precancerous condition, leukoplakia, was develop at 6 weeks treatment of DMBA whereas in the animals treated both DMBA + Vit. A, leukoplakia was seen at 10 weeks followed by papilloma or nodules at 12 weeks. Tumours induced by DMBA were more in number than DMBA + Vit. A treated tumours. The histological and ultrastructural changes were enhanced and prominent in DMBA treated animals at 12 weeks, where as these changes were considerably less in animals treated with DMBA + vit. A at 12 weeks.
Kandarkar
S V
SV
Cell Biology Division, Cancer Research Institute, Bombay, India.
Sirsat
S M
SM
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D006224:Cricetinae; D005260:Female; D007972:Leukoplakia, Oral / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene