[A lymphotropic method of therapy for patients with fresh forms of syphilis (clinical and experimental research)].
Experimental study of benzylpenicillin procain salt kinetics in lymphotropic and intramuscular administration of 600,000 U has revealed a more intensive saturation of the lymph system and a longer persistence of high concentrations of the drug in the blood serum, organs and tissues of the body after lymphotropic administration, as against intramuscular one. Comparison of the efficacies of 16-day courses of therapy of patients with fresh syphilis with benzylpenicillin procain salt administered lymphotropically (once daily, 600,000 U) or intramuscularly (twice daily, the same dose) has shown the advantages of the former method as regards the therapeutic, pharmacokinetic, and economic aspects.
Zoirov
P T
PT
Khaĭdarov
K Kh
KKh
Isaeva
M S
MS
Iskhaki
D F
DF
D000293:Adolescent; D000328:Adult; D000818:Animals; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007272:Injections, Intralymphatic; D007273:Injections, Intramuscular; D008875:Middle Aged; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000493:pharmacokinetics; D013587:Syphilis / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors; D014018:Tissue Distribution
D010402:Penicillin G Procaine
Limfotropnyĭ metod terapii bol'nykh svezhimi formami sifilisa (kliniko-éksperimental'nye issledovaniia).