Axonal neuropathy with monoclonal IgG kappa that binds to a neurofilament protein.
We report a 74-year-old woman with a slowly progressive sensory motor axonal neuropathy and a monoclonal IgG-kappa that bound to a 68-kd axonal protein identified as the low molecular weight neurofilament protein. The sera of control subjects and disease controls did not bind to neurofilament protein.
Nemni
R
R
Department of Neurology, University of Milan, Istituto Scientifico S. Raffaele, Italy.
Feltri
M L
ML
Fazio
R
R
Quattrini
A
A
Lorenzetti
I
I
Corbo
M
M
Canal
N
N
D000368:Aged; D001369:Axons; D004594:Electrophysiology; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000378:metabolism*; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010265:Paraproteinemias / Q000378:metabolism*; D013497:Sural Nerve / Q000473:pathology
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007381:Intermediate Filament Proteins