[Changes in the morphological structure of the skin and internal organs of guinea pigs after multiple epicutaneous exposures to furfural, a distillate of D-11 mineral oil and their combinations].
Experimental multiple epicutaneous exposure of guinea pigs to furfural and D-11 mineral oil distillate and their combinations in various concentrations has resulted in structural changes of the skin and viscera. These changes were dose-dependent. Combined exposure to both agents resulted in more grave disorders than isolated exposures in the same doses.
Agakishiev
D D
DD
D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005662:Furaldehyde / Q000633:toxicity*; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008899:Mineral Oil / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D008899:Mineral Oil; D005662:Furaldehyde
Izmenenie morfologicheskoĭ struktury kozhi i nekotorykh vnutrennikh organov morskikh svinok posle mnogokratnogo épikutannogo vozdeĭstviia furfurola, distilliata mineral'nogo masla D-11 i ikh kombinatsiĭ.