The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema.
Critical elements of the mechanisms of emphysema remain to be clarified. However, taken together, the existing evidence supports the concept that alveolar matrix destruction ensues as the regulatory interplay between oxidant and protease expression is subverted. The final common pathway of matrix destruction links the inherited and acquired forms of emphysema through the ultimate expression of unimpeded neutrophil elastase.
Gadek
J E
JE
Division of Pulmonary and Critical Care Medicine, Ohio State University College of Medicine, Columbus.
Pacht
E R
ER
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D011656:Pulmonary Emphysema / Q000201:enzymology*; D012907:Smoking / Q000009:adverse effects; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D000975:Antioxidants; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D010447:Peptide Hydrolases