A case of primary osseous malignant immunoblastic B-cell lymphoma with intracytoplasmic mu lambda immunoglobulin inclusions.
Primary malignant lymphoma of bone, so-called Parker-Jackson reticulosarcoma, is a rare form of extranodal lymphoma with a relatively good prognosis. It often corresponds to B-cell lymphoma of high-grade malignancy. We report a case of mu lambda immunoblastic lymphoma showing two distinctive features: an abundant reactive T-lymphocytic population and unusual intra-cytoplasmic inclusions. These inclusions were PAS positive and consisted of monotypic mu lambda immunoglobulin localized in peculiar aggregates of rough endoplasmic reticulum. Their morphological appearances resembled the well-documented inclusions described in some varieties of non-Hodgkin's lymphoma.
Fiche
M
M
Service Central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu, Paris, France.
Le Tourneau
A
A
Audouin
J
J
Touzard
R C
RC
Diebold
J
J
D000368:Aged; D001859:Bone Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000378:metabolism*; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology* / Q000473:pathology
D007148:Immunoglobulin mu-Chains