title: Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
abstract: The carcinogenic potential of caffeic acid, sesamol and catechol was examined in male and female F344 rats and B6C3F1 mice, groups of 30 animals being treated with diets containing 2% caffeic acid, 2% sesamol or 0.8% catechol for 104 weeks (rats) or 96 weeks (mice). Histological examination revealed that caffeic acid induced forestomach squamous cell carcinoma in 57% (P less than 0.001 vs. controls) and 50% (P less than 0.001) of male and female rats, respectively, whereas sesamol was associated with squamous cell carcinoma at incidences of 31% (P less than 0.001) in male rats, and 38% (P less than 0.001) and 17% (P less than 0.05) in male and female mice, respectively. Catechol induced glandular stomach adenocarcinomas in 54% (P less than 0.001) and 43% (P less than 0.001) of male and female rats, respectively. The results thus clearly demonstrated that all three antioxidants are carcinogenic in rodent stomach epithelia.
authors.affiliation: First Department of Pathology, Nagoya City University Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Hirose
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: T
authors.initials: T
authors.lastname: Shirai
authors.forename: R
authors.initials: R
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: E
authors.initials: E
authors.lastname: Asakawa
authors.forename: N
authors.initials: N
authors.lastname: Ito
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000633:toxicity*; D052117:Benzodioxoles; D001835:Body Weight; D002109:Caffeic Acids / Q000633:toxicity*; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D002396:Catechols / Q000633:toxicity*; D002934:Cinnamates / Q000633:toxicity*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology; D010636:Phenols / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012509:Sarcoma / Q000139:chemically induced / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000975:Antioxidants; D052117:Benzodioxoles; D002109:Caffeic Acids; D002273:Carcinogens; D002396:Catechols; D002934:Cinnamates; D010636:Phenols; C025583:sesamol; C034221:catechol; C040048:caffeic acid