title: The pathology of experimental respiratory infection with Pasteurella multocida and Bordetella bronchiseptica in rabbits.
abstract: Groups of female New Zealand White rabbits, 8-10 weeks old, were inoculated intranasally with three different Pasteurella multocida serotypes (A:3, A:4 and A:12) or one of three Bordetella bronchiseptica strains of rabbit origin. Seven out of 18 rabbits died of experimental infection with P. multocida. B. bronchiseptica killed 3 out of the 8 animals inoculated with it. Deaths occurred between 3 and 6 days postinoculation (PI). In the rabbits that died of P. multocida inoculation, necropsy and histology revealed severe pleuritis with the accumulation of a remarkable amount of fibrinopurulent exudate in the thoracic cavity, serous rhinitis and tracheitis, acute hepatitis with necrotic foci in the parenchyma, and atrophy of the lymphoid organs and tissues. Rabbits killed 10 days PI developed only subacute serous rhinitis and hyperplasia of the lymphoid tissues. Rabbits that died of B. bronchiseptica inoculation showed acute serous rhinitis, acute catarrhal-fibrinopurulent pneumonia and mild pleuritis. As opposed to P. multocida inoculated animals, hepatitis and atrophy of the lymphoid tissues were not characteristic of these rabbits. Rabbits killed 10 days PI developed subacute purulent and necrotic pneumonia with remarkable macrophage proliferation, involving all lobes, and hyperplasia of the lymphoid tissues.
authors.affiliation: Central Veterinary Institute, Budapest, Hungary.
authors.forename: R
authors.initials: R
authors.lastname: Glávits
authors.forename: T
authors.initials: T
authors.lastname: Magyar
mesh_terms: D000818:Animals; D001885:Bordetella Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008099:Liver / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology; D010326:Pasteurella Infections / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits; D012137:Respiratory System / Q000473:pathology; D012141:Respiratory Tract Infections / Q000473:pathology / Q000662:veterinary*