Effect of ethanol on hepatic oxygenation: evidence of hepatic hypoxia.
The effects of low (1 g/kg body wt) and high doses (4 g/kg body wt) of ethanol on hepatic oxygenation in rats was investigated employing an in vivo microscopic and spectrophotometric system and also a micro oxygen electrode. The low dose of ethanol increased sinusoidal blood hemoglobin oxygenation (ISO2) at periportal regions in the liver lobule. The high dose of ethanol increased ISO2 at periportal regions, but decreased ISO2 at pericentral regions. The low dose of ethanol increased hepatic surface tissue PO2, but the high dose decreased this PO2. From these data it is concluded that the increase of hepatic blood flow, after administration of a low dose of ethanol, compensated for the increase of oxygen demand in hepatocytes but that administration of a high dose of ethanol reduced hepatic tissue oxygenation via an imbalance between delivery and demand of oxygen in pericentral regions of the liver lobule, resulting in local hypoxia in surface hepatic tissue.
Fukui
H
H
First Dept. of Medicine, Osaka University Medical School, Japan.
Sato
N
N
Kawano
S
S
Yoshihara
H
H
Hijioka
T
T
Eguchi
H
H
Goto
M
M
Matsunaga
T
T
Kubota-Kashio
S
S
Kamada
T
T
D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D000860:Hypoxia / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D010100:Oxygen