title: De novo biosynthesis of FSH like peptide by the human prostate.
abstract: Human benign prostatic hyperplasia tissue is able to synthesize immunoreactive FSH (IR FSH) in vitro. The prostatic FSH is similar to pituitary FSH as evident by co-elution on Sephadex G-100. High performance gel filtration chromatography and Western blot analysis. Immunocytochemical localization studies indicate positive staining in the cytoplasm of prostatic epithelial cells. There is a two fold increase in the concentration of immunoreactive FSH in benign hyperplastic tissue as compared to normal prostate.
authors.affiliation: Institute for Research in Reproduction (ICMR), Bombay, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Hurkadli
authors.forename: M G
authors.initials: MG
authors.lastname: Shah
authors.forename: D S
authors.initials: DS
authors.lastname: Pardanani
authors.forename: A R
authors.initials: AR
authors.lastname: Sheth
mesh_terms: D015153:Blotting, Western; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004847:Epithelial Cells; D005640:Follicle Stimulating Hormone / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D006965:Hyperplasia; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011863:Radioimmunoassay
chemical_list: D005640:Follicle Stimulating Hormone