Preventive effects of an immunostimulating product on recurrent infections of chronic bronchitis in the elderly.
The effect of an immunostimulating drug, OM-85 BV, was demonstrated on recurrent infection rates in 265 elderly patients with a defined state of chronic bronchitis, during a 6-month, double-blind, placebo-controlled trial. Patients receiving OM-85 BV presented less infections (p = 0.005) and a significantly reduced intake of antibiotics (p = 0.02) as compared to those receiving a placebo and the antibiotic intake was significantly reduced (p = 0.02).
Debbas
N
N
Centre de Recherche des Laboratoires Fournier, Dijon, France.
Derenne
J P
JP
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria; D001991:Bronchitis / Q000276:immunology / Q000628:therapy*; D002457:Cell Extracts; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D008297:Male; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000276:immunology / Q000628:therapy*; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D002457:Cell Extracts; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates