Effect of donor parameters on primary graft failure and the recovery of acuity after keratoplasty.
A retrospective evaluation was made of 983 penetrating corneal grafts. Donor corneas stored in either K-Sol or McCarey-Kaufman media had a significantly greater rate of primary graft failure (about 2%) than those kept in moist chamber storage (0%). Selected subgroups of 50 corneas from each storage system were studied to determine the time taken to reach a postoperative acuity of 6/12. No significant correlation was found between this time and either the duration of storage of donor corneas or the age of donor. A significant delay in recovery of visual acuity was found with increasing age of recipient. The increased average time from donor death to surgery for K-Sol (56 hours) and McCarey-Kaufman (40 hours) corneas compared with moist chamber corneas (15 hours) facilitated the scheduling of surgery at the cost of increased chance of primary graft failure.
Halliday
B L
BL
Moorfields Eye Hospital, London.
Ritten
S A
SA
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates; D016039:Corneal Transplantation; D003470:Culture Media; D005839:Gentamicins; D006085:Graft Survival; D006531:HEPES; D006801:Humans; D008875:Middle Aged; D009930:Organic Chemicals; D011184:Postoperative Period; D012189:Retrospective Studies; D014019:Tissue Donors; D014021:Tissue Preservation; D014792:Visual Acuity
D003470:Culture Media; D005839:Gentamicins; C051174:K-Sol preserving medium; C015368:McCarey-Kaufman medium; D009930:Organic Chemicals; D002809:Chondroitin Sulfates; D006531:HEPES