Dependence of cerebral capillary hematocrit on red cell flow separation at bifurcations: a computer simulation study.
The influence of preferential red cell entry into microvascular branches with higher flow on microvessel hematocrit distribution was studied by mathematical modeling in a reconstructed cerebrocortical microvascular network. More heterogeneous hematocrit distribution was obtained at stronger cell partitioning. Small variations in the cell separation parameter resulted in significantly different hematocrit distributions. The significance of these findings in vivo should be further evaluated.
Hudetz
A G
AG
Department of Physiology, Medical College of Wisconsin, Milwaukee.
D000818:Animals; D002196:Capillaries / Q000033:anatomy & histology / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D004912:Erythrocytes / Q000502:physiology*; D006400:Hematocrit; D008954:Models, Biological; D051381:Rats