A case of bupropion-associated delirium.
The authors report a case of bupropion-associated delirium characterized by disorganized thinking, memory impairment, fear, and agitation but not disorientation, delusions, hallucinations, or other perceptual distortions. Symptom onset appeared to be dose-related, and a sustained therapeutic response was subsequently obtained at a lower dose of bupropion without recurrence of delirium. Abnormal bupropion metabolism and elevated plasma metabolite levels did not account for the adverse reaction, which instead was hypothesized to reflect dopaminergic effects of bupropion.
Dager
S R
SR
Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine, Seattle.
Heritch
A J
AJ
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D016642:Bupropion; D003693:Delirium / Q000139:chemically induced*; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D011427:Propiophenones / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion