Effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in mice.
The prophylactic and curative effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in MF-1 mice were assessed. The drugs were administered orally. At 240 mg/kg praziquantel, there was a reduction of 89.1% in adult worm recovery and a marked reduction in tissue deposited eggs. The reduction in adult worm recovery after dosing with 50 mg/kg oxamniquine was 89.2%. At low doses (40 mg/kg praziquantel and 30 mg/kg oxamniquine) administered at 11 days, 5 days and 3 h before and 5, 21 and 49 days after infection, the reduction in adult worm recovery was 0.0%, 65.1%, 58.8%, 33.6%, 0.0% and 76.0% for praziquantel and 0.0%, 66.0%, 60.0%, 41.3%, 10.8% and 79.0% for oxamniquine. Numbers of lung schistosomula and the size of hepatic granulomata were also reduced.
Ghandour
A M
AM
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Banaja
A A
AA
Shalaby
I M
IM
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D012529:Saudi Arabia; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000517:prevention & control
D009600:Nitroquinolines; D010073:Oxamniquine; D011223:Praziquantel