[The effect of China-made amrinone on myocardial infarction and arrhythmia in dogs].
Six dogs underwent 15 min left anterior descending (LAD) coronary artery occlusion (CAO) with 1 hour's reperfusion for 3 times. Fifteen min after CAO (control), CAO during amrinone (Amr), and CAO during isoprenaline, sigma ST (mV) and ST (mV) were 66 +/- 26 and 8 +/- 2.72 +/- 61 and 9 +/- 4.90 +/- 48 and 11 +/- 6 respectively, 24h after LAD CAO, dP/dt max (kPa/s) and HR (heart beats/min) were 483 +/- 93 and 211 +/- 36 respectively. Intravenous Amr by 1, 5, 3 and 6 mg/kg increased dP/dt max to 630 +/- 79, 583 +/- 116 and 500 +/- 148; HR to 223 +/- 44, 232 +/- 45 and 239 +/- 54; and also decreased SBP, DBP and LVEDP. Amr caused neither change in percentage of non-sinus beats, nor ventricular fibrillation. These results suggested that in myocardial infarction and arrhythmia, Amr could still be of positive inotropic effect. Amr worsened myocardial infarction in nonfailing heart, but it did not aggravated arrhythmia after myocardial infarction.
Xu
D
D
Department of Pharmacology, School of Pharmacy.
Yang
Z
Z
D000676:Amrinone / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D013268:Stimulation, Chemical
D000676:Amrinone