Transcutaneous oxygen tension during prostacyclin infusion in distal limb ischaemia.
Transcutaneous oxygen tension measurement is an established method for monitoring immediate drug actions. The effects of prostacyclins in advanced limb ischaemia are controversial. To evaluate the immediate effects of epoprostenol infusion (10 ng/kg/min) on forefoot circulation, ten patients with distal ischaemia lesions were evaluated. During infusions systemic blood pressure was lowered, toe temperature elevated but transcutaneous oxygen tension was not changed. These results suggest a vasodilating action of the epoprostenol but contradict immediate positive effects on skin oxygenation.
Lepäntalo
M
M
Fourth Department of Surgery, University Central Hospital, Helsinki, Finland.
Hietaniemi
K
K
D000328:Adult; D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005545:Forefoot, Human / Q000098:blood supply*; D006801:Humans; D007262:Infusions, Intravenous; D007511:Ischemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D013997:Time Factors
D011464:Epoprostenol; D010100:Oxygen