title: Investigation of the possible role of endotoxin, TXA2, PGI2 and PGE2 in experimentally induced rumen acidosis in cattle.
abstract: Rumen acidosis was induced experimentally with 70 g barley/kg b.w. in 2 rumen fistulated cows. The cows were followed for 80 h after the grain engorgement. Endotoxin was monitored in cell-free ruminal fluid and peripheral plasma together with inflammation mediators TXA2, PGI2 and PGE2 and several clinical and clinical-chemical parameters. The results do not support the theory of systemical endotoxemia due to a large increase in rumen endotoxin concentration in cattle suffering from rumen acidosis. However, both clinical and clinical-chemical data suggest that an endotoxicosis developed, but the levels of inflammation mediators TXB2, FGI2 and PGE2 were not significantly elevated in the peripheral circulation. An absorbtion of endotoxins and synthesis of inflammation mediators are therefore suggested to take place prehepatically.
authors.affiliation: Department of Clinical Studies, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Haubro Andersen
authors.forename: N
authors.initials: N
authors.lastname: Jarløv
mesh_terms: D000138:Acidosis / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D015232:Dinoprostone / Q000097:blood; D004731:Endotoxins / Q000032:analysis; D011464:Epoprostenol / Q000097:blood; D005260:Female; D012417:Rumen; D013272:Stomach Diseases / Q000209:etiology / Q000662:veterinary*; D013928:Thromboxane A2 / Q000097:blood
chemical_list: D004731:Endotoxins; D013928:Thromboxane A2; D011464:Epoprostenol; D015232:Dinoprostone