Octamer-binding proteins in diverse hemopoietic cells.
The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which binds the octamer element (ATTTGCAT). We have further examined the role of this octamer element in directing the lymphoid-specific expression of the immunoglobulin H enhancer. No direct relationship was found between the levels of expression of the Cmu gene and oct-2. Indeed, variable amounts of oct-2 were detected in all of the hemopoietic lineage cells tested in this study.
Cockerill
P N
PN
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.
Klinken
S P
SP
D000818:Animals; D015152:Blotting, Northern; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000502:physiology*; D004742:Enhancer Elements, Genetic; D015870:Gene Expression; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology; D050813:Octamer Transcription Factor-2; D012333:RNA, Messenger / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D009687:Nuclear Proteins; D050813:Octamer Transcription Factor-2; C489206:Pou2f2 protein, mouse; D012333:RNA, Messenger; D014157:Transcription Factors