The cosubstrate NADP(H) protects lysine 601 in the porcine NADPH-cytochrome P-450 reductase against pyridoxylation.
Lys601 in NADPH-cytochrome P-450 reductase is modified by reductive alkylation with pyridoxal 5'-phosphate (pyridoxylation). Lys601 is protected against modification by the cosubstrate NADP(H).
Müller
K
K
Biochemisches Institut (Fachbereich Humanmedizin), Justus Liebig Universität, Giessen, FRG.
Linder
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D
Lumper
L
L
D000478:Alkylation; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D008099:Liver / Q000201:enzymology; D008239:Lysine / Q000032:analysis*; D009249:NADP / Q000494:pharmacology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis* / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction / Q000187:drug effects; D011732:Pyridoxal Phosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013379:Substrate Specificity; D013552:Swine
D009249:NADP; D011732:Pyridoxal Phosphate; D009251:NADPH-Ferrihemoprotein Reductase; D008239:Lysine