title: [Antiphospholipid syndrome and cardiovascular disease].
abstract: Recurrent thrombosis, abortion and thrombocytopenia are the most frequent manifestation of antiphospholipid syndrome, which usually presents antibodies against some anionic phospholipids. A few years ago, this syndrome was considered as a manifestation of systemic lupus erythematosus; nowadays it is classified as an isolated systemic lupus erythematosus; nowadays it is classified as an isolated autoimmune disease. Hypotheses have been proposed to explain the origin of antiphospholipid antibodies, including infectious and autoimmune diseases with high titles of anticardiolipin antibodies. Genetic factors have also been involved. Laboratory tests of choice for the detection of anticardiolipin antibodies are RIA and ELISA tests; there are some structural differences among them depending on the underlying disease. Hypercoagulability and recurrent thrombosis are the main features of this entity; ischemic heart disease is in this context of outmost importance. Despite the lack of any clinically demonstrated association between antiphospholipid syndrome and ischemic heart disease, there are many "in vitro" studies that support this possibility.
authors.affiliation: Departamento de Cardiología y Cirugía Cardiovascular, Facultad de Medicina, Universidad de Navarra, Pamplona.
authors.forename: J I
authors.initials: JI
authors.lastname: García Bolao
authors.forename: I
authors.initials: I
authors.lastname: Iglesias
authors.forename: M L
authors.initials: ML
authors.lastname: Fidalgo
authors.forename: E
authors.initials: E
authors.lastname: Alegría
authors.forename: S
authors.initials: S
authors.lastname: Mejía
authors.forename: A
authors.initials: A
authors.lastname: Huelmos
authors.forename: C
authors.initials: C
authors.lastname: Garrote
mesh_terms: D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology; D003327:Coronary Disease / Q000276:immunology*; D005313:Fetal Death / Q000276:immunology; D006801:Humans; D010743:Phospholipids / Q000276:immunology*; D013577:Syndrome; D013921:Thrombocytopenia / Q000276:immunology; D013927:Thrombosis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D002308:Cardiolipins; D010743:Phospholipids
vernacular_title: Síndrome antifosfolípido y enfermedad cardiovascular.