title: LDL cholesterol: its regulation and manipulation.
abstract: Elevated plasma LDL cholesterol concentrations result primarily from two mechanisms: LDL overproduction and loss of hepatic receptor-dependent LDL removal. This knowledge can be used to lower plasma cholesterol and thereby retard or even reverse atherosclerosis. Pharmacologic agents are useful, as are dietary approaches.
authors.affiliation: Department of Medicine, University of Texas Southwestern Medical Center, Dallas.
authors.forename: J M
authors.initials: JM
authors.lastname: Dietschy
mesh_terms: D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000628:therapy; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000502:physiology; D011973:Receptors, LDL / Q000502:physiology
chemical_list: D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D011973:Receptors, LDL