title: Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man.
abstract: The three members of the jun proto-oncogene family c-jun, jun b and jun D were mapped on the mouse chromosome by in situ hybridization. The c-jun locus is on chromosome 4 subregion C5----C7, whereas jun B and jun D are co-localized on chromosome 8 subregion C. RFLP analysis of interspecific hybrids confirmed the mapping of jun B and D and showed that they are situated about 7.3 +/- 3.5 cM apart. Thus despite their possible origin from a single ancestral gene they are not closely linked on the chromosome. Using the same probes, we showed that the human genome also contains sequences homologous to the mouse jun B and jun D. They are located on human chromosome 19 p13.2, a region that may be involved in chromosomal translocation in acute lymphocytic leukemia (ALL), acute nonlymphocytic leukemia (ANLL) and malignant melanoma (MEL). Finally, the present data identify a new segmental homology between mouse and human chromosomes.
authors.affiliation: INSERM U242, Hôpital d'enfants de la Timone, Marseille, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: D
authors.initials: D
authors.lastname: Simon-Chazottes
authors.forename: S
authors.initials: S
authors.lastname: Hirai
authors.forename: R P
authors.initials: RP
authors.lastname: Ryseck
authors.forename: Z
authors.initials: Z
authors.lastname: Galcheva-Gargova
authors.forename: J L
authors.initials: JL
authors.lastname: Guénet
authors.forename: J F
authors.initials: JF
authors.lastname: Mattei
authors.forename: R
authors.initials: R
authors.lastname: Bravo
authors.forename: M
authors.initials: M
authors.lastname: Yaniv
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors