The effects of thiamin on the tissue distribution of lead.
The effects of thiamin on the tissue distribution of lead were evaluated in Sprague-Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg-1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg-1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P less than 0.0001), liver (P less than 0.0001) and kidney (P less than 0.0001) concentrations of lead. Thiamin (50 mg kg-1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg-1 body weight). The combined treatment was more effective than the respective individual treatments.
Kim
J S
JS
Department of Veterinary Physiological Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Blakley
B R
BR
Rousseaux
C G
CG
D000818:Animals; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000494:pharmacology*; D014018:Tissue Distribution
D007854:Lead; D004492:Edetic Acid; D013831:Thiamine