[Secretion of plasminogen activators and their inhibitors in corneal fibroblasts. Modification of this secretion in Schnyder's lens corneal dystrophy].
In this study, we have shown that the secretion of plasminogen activators (PA) by corneal fibroblasts from Schnyder dystrophy is much lower than that secreted by normal corneal fibroblasts. This defective secretion of PA was noted both in the supernatant of cell culture and on the cell surface. This anomaly is found in cultured fibroblasts and therefore is not related to environment modification. Since PA was implicated in remodeling of extracellular matrix, we hypothesized that this anomaly should be responsible for the corneal dystrophy.
Mirshahi
M
M
Unité 86 de l'I.N.S.E.R.M., Faculté de Médecine, Paris-VI.
Mirshahi
S S
SS
Soria
C
C
Lorans
G
G
Soria
J
J
Bureau
J
J
Thomaidis
A
A
Pouliquen
Y
Y
D002478:Cells, Cultured / Q000378:metabolism; D003315:Cornea / Q000166:cytology / Q000473:pathology*; D003317:Corneal Dystrophies, Hereditary / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D010960:Plasminogen Activators / Q000378:metabolism*; D015849:Plasminogen Inactivators / Q000378:metabolism*
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators
Sécrétion des activateurs du plasminogène et de leurs inhibiteurs par les fibroblastes cornéens. Modification de cette sécrétion dans la dystrophie cornéenne cristalline de Schnyder.