[Experimental combination chemotherapy of YNK01, a novel analog of cytarabine, with other antitumor agents].
Combined activity of 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone 5'-(sodium octadecyl phosphate) monohydrate, YNK01, with other antitumor agents was studied with mouse P388 and L1210 leukemia in vivo. The two-drug combinations with doxorubicin, daunorubicin, mitomycin C, cisplatin or vincristine showed marked synergistic effects against P388 leukemia. However, YNK01 plus methotrexate showed additive or competitive effect. Among these combinations, the combination with doxorubicin showed greatest activity and the number of cured mice were observed in a wide dose range. In a three-drug combination with daunorubicin and 6-mercaptopurine against L1210 leukemia, the combined effect was more synergistic than two-drug combinations with each of the three drugs. From these results, YNK 01 is expected to be a useful agent in combination chemotherapy.
Uchida
T
T
Research Laboratories, Nippon Kayaku Co., Ltd.
Nagahata
T
T
Arakawa
M
M
Ekimoto
H
H
Takahashi
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001088:Arabinonucleotides / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003568:Cytidine Monophosphate / Q000008:administration & dosage* / Q000031:analogs & derivatives; D003597:Cytosine Nucleotides / Q000008:administration & dosage*; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004357:Drug Synergism; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy*; D015122:Mercaptopurine / Q000008:administration & dosage; D051379:Mice; D008811:Mice, Inbred DBA; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D001088:Arabinonucleotides; D003597:Cytosine Nucleotides; D008937:Mitomycins; C061162:1-arabinofuranosylcytosine-5'-stearylphosphate; D016685:Mitomycin; D014750:Vincristine; D004317:Doxorubicin; D015122:Mercaptopurine; D003568:Cytidine Monophosphate; D002945:Cisplatin; D003630:Daunorubicin