[Serum gamma interferon levels in relation to tumor necrosis factor and interleukin 2 receptor in patients with Kawasaki disease involving coronary-artery lesions].
Serum levels of gamma interferon (IFN-gamma) were determined by a sandwich radioimmunoassay in 45 patients with Kawasaki disease (KD), 14 with measles, 3 with streptococcal infection, 17 with anaphylactoid purpura, 6 with various vasculitis and also in 10 healthy children. Serum levels of IFN-gamma were seen to increase during the acute phase of KD and measles. In addition, serum levels of tumor necrosis factor (TNF) and interleukin 2 receptor (IL-2R) were measured simultaneously in 45 patients with KD. In KD patients with coronary-artery lesions (CAL), the percentage of positive cases for TNF (greater than or equal to 10 units/ml), IL-2R (greater than or equal to 1056 units/ml) and IFN-gamma (greater than or equal to 0.3 units/ml) was higher than that in patients without CAL. Several cytokines in association with activated monocytes/macrophages and T lymphocytes were detected in the serum during acute KD. These results suggest that aggressive activation of immuno-competent cells develops in KD involved CAL.
Matsubara
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Department of Pediatrics, School of Medicine, Juntendo University.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*; D011863:Radioimmunoassay; D015375:Receptors, Interleukin-2 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma