title: [Contraceptives and ischemic cardiopathy].
abstract: The incidence of myocardial infarction is higher in women that use oral contraceptives. The most important pathophysiologic mechanisms are: a) modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus; b) blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity. At this moment there are several update publications concerning this matter; however most of the mechanisms involved in the increase of coronary heart disease in this specific group still remain unclear.
authors.affiliation: Departamento de Cardiología y Cirugía Cardiovascular, Facultad de Medicina, Universidad de Navarra, Pamplona.
authors.forename: I
authors.initials: I
authors.lastname: García-Bolao
authors.forename: E
authors.initials: E
authors.lastname: Alegría
authors.forename: I
authors.initials: I
authors.lastname: Iglesias
authors.forename: S
authors.initials: S
authors.lastname: Velasco
authors.forename: P
authors.initials: P
authors.lastname: Alzamora
authors.forename: M L
authors.initials: ML
authors.lastname: Fidalgo
mesh_terms: D001161:Arteriosclerosis / Q000139:chemically induced; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D002784:Cholesterol / Q000378:metabolism*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D003327:Coronary Disease / Q000139:chemically induced*; D003920:Diabetes Mellitus / Q000139:chemically induced; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D011372:Progestins / Q000009:adverse effects; D013329:Structure-Activity Relationship
chemical_list: D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D011372:Progestins; D002784:Cholesterol
vernacular_title: Contraceptivos y cardiopatía isquémica.