title: Blood coagulation alterations after embolic occlusion of the renal circulation.
abstract: Alterations in blood coagulation and fibrinolysis after embolic occlusion of renal adenocarcinoma were investigated in 11 patients. Peripheral vein blood was collected before, 2 hours after and on the first, third and fifth to seventh day after embolization. Five patients had renal vein blood sampling before and 2 hours after embolization. Increased levels of fibrinogen, plasminogen and antiplasmin were found on days 1-3. Antithrombin III showed a slight decrease between days 1 and 3 after embolization. All measured variables were lower in renal vein compared with simultaneous samples from peripheral vein. In renal vein samples, consumption of antiplasmin and antikallikrein was indicated. Fibrinopeptide A (FPA) was increased, with a mean maximum 2 hours after embolization. The findings seemed mainly to monitor acute phase reaction but also activation of blood coagulation and fibrinolysis. Embolization might be used as a human model of coagulation activation and acute phase reaction.
authors.affiliation: Department of Surgery, Södersjukhuset, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Törngren
authors.forename: L E
authors.initials: LE
authors.lastname: Almgård
authors.forename: M
authors.initials: M
authors.lastname: Blombäck
authors.forename: U
authors.initials: U
authors.lastname: Norming
authors.forename: C R
authors.initials: CR
authors.lastname: Nyman
mesh_terms: D000210:Acute-Phase Reaction / Q000209:etiology; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009132:Muscles; D012079:Renal Circulation
chemical_list: D001779:Blood Coagulation Factors