[Effect of fasting and elemental carbohydrate feeding on the liver resistance to the action of cytostatics].
To study the influence of cyclophosphamide and methotrexate on the function of isolated perfused liver, and the hepatoprotective effect of starvation and parenteral glucose feeding, the authors conducted 57 tests on the rabbit liver. It was established that addition of cyclophosphamide, and, especially, of methotrexate into the perfusate negatively affected the function of the isolated perfused liver. Parenteral glucose feeding produced a protective effect on the isolated liver against the detrimental action of both methotrexate and cyclophosphamide.
Kozlov
S A
SA
Zinov'ev
Iu V
IuV
D000818:Animals; D003470:Culture Media; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005215:Fasting / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008727:Methotrexate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D010288:Parenteral Nutrition; D011817:Rabbits
D003470:Culture Media; D003520:Cyclophosphamide; D005947:Glucose; D008727:Methotrexate
Vliianie alimentarnogo golodaniia i élementnogo uglevodnogo pitaniia na rezistentnost' pecheni k deĭstviiu tsitostatikov.