Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing-hormone-releasing hormone.
To examine the role of neuropeptide Y (NPY) in the first luteinizing hormone (LH) surge of puberty, the effect of passive immunoneutralization of NPY with antiserum against NPY (anti-NPY) injected centrally (third ventricle) or peripherally (jugular vein) was studied in pubertal female rats on the day of first proestrus. Both peripheral and central anti-NPY administration reduced the magnitude of the LH surge during the afternoon of first proestrus; however, the central route of administration appeared to be most effective. Centrally administered anti-NPY also reduced the magnitude of proestrous LH-releasing hormone (LHRH) release into pituitary portal blood in these rats. These results suggest that endogenous NPY plays a facilitatory role in the generation of the LHRH surge necessary for preovulatory gonadotropin release and puberty.
Minami
S
S
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman.
Frautschy
S A
SA
Plotsky
P M
PM
Sutton
S W
SW
Sarkar
D K
DK
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007106:Immune Sera; D007986:Luteinizing Hormone / Q000378:metabolism*; D009478:Neuropeptide Y / Q000276:immunology / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000502:physiology*
D007106:Immune Sera; D009478:Neuropeptide Y; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone