title: Osteoporosis and diabetes: lessons from the diabetic BB rat.
abstract: The spontaneously diabetic BB rat was used to study the effect of diabetes on bone. Short-term diabetes (3-4 weeks) resulted in a state of low bone turnover, characterized by a severe decrease in osteoblast/osteoid surface and bone mineral apposition rate on histology, and in serum osteocalcin concentrations. If diabetes was long-term (12 weeks), the parameters of low bone formation were associated with histological evidence of osteoporosis and a decreased bone strength; the relative bone calcium concentration remained normal in diabetes. We conclude that long-standing diabetes results in a low-turnover osteoporosis.
authors.affiliation: Laboratory of Experimental Medicine and Endocrinology, K.U. Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Verhaeghe
authors.forename: W J
authors.initials: WJ
authors.lastname: Visser
authors.forename: T A
authors.initials: TA
authors.lastname: Einhorn
authors.forename: R
authors.initials: R
authors.lastname: Bouillon
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000209:etiology*; D051381:Rats; D011913:Rats, Inbred BB; D013977:Tibia / Q000473:pathology
chemical_list: D015675:Osteocalcin