A case of malignant mastocytosis with near-haploid, near-diploid, and polyploid cells in the bone marrow.
Chromosome analysis in bone marrow cells of a 41-year-old woman with malignant mastocytosis (MM) revealed near-haploid (59%), near-diploid (36%), and polyploid (5%) cells. Near-haploid cells had a mode of 25 chromosomes with variable disomy and nullisomy of particular chromosomes. Disomy for chromosome 19 and chromosome 20 were most common. A 17p+ marker was observed in all cells. Other structural chromosomal changes were dicentrics, ring chromosomes, translocations, and double minutes. The modal chromosome number in near-diploid cells was 46 with a range of 41-52. The majority of cells with 46 chromosomes were pseudodiploid and only a few had a normal female karyotype. As in near-haploid cells, various structural chromosomal changes were found. The 17p+ marker was also present in occasional cells suggesting a relationship between the two tumor cell populations. Chromosome numbers in polyploid cells ranged from 70 to about 600. Identical copies of dicentrics or markers were identified in some cells.
Bauchinger
M
M
Institut für Strahlenbiologie, GSF, Neuherberg/München, F.R.G.
Mezger
J
J
D000328:Adult; D001853:Bone Marrow / Q000473:pathology* / Q000648:ultrastructure; D002871:Chromosome Banding; D004171:Diploidy; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D007946:Leukemia, Mast-Cell / Q000235:genetics* / Q000473:pathology; D008415:Mastocytosis / Q000235:genetics* / Q000473:pathology; D011003:Ploidies; D011123:Polyploidy