Comparison of the diuretic effect and absorption of a single dose of furosemide and free and the fixed combinations of furosemide and triamterene in healthy male adults.
The absorption and diuretic effect of furosemide 40 mg alone (F), and of the free (F + T) and the fixed (FT) combinations of furosemide 40 mg and triamterene 50 mg have been compared in 12 healthy young men. A slight reduction in the area under the concentration-time curve (AUC) of plasma furosemide was found for the fixed combination (AUC480) F2.58 micrograms.h.ml-1; F + T 2.46 micrograms.h.ml-1; FT 1.97 micrograms.h.ml-1. There was a significant reduction in the AUC480 of plasma triamterene (F + T 204.9 micrograms.h.l-1; FT 130.2 micrograms.h.l-1). Sodium excretion after F + T and FT was more pronounced than after F (F + T 302 mmol; FT 311 mmol; F259 mmol). When compared to F alone, there was a reduction in the 24-hour potassium excretion after F + T as well as after FT (F 121 mmol; F + T 104 mmol; FT 107 mmol). It is concluded that the absorption of triamterene was significantly reduced after ingestion of the fixed combination tablet. However, in healthy male adults this had no influence on its natriuretic and potassium-sparing effect as compared to the free combination.
van Meyel
J J
JJ
Department of Pharmacology and Clinical Pharmacology, University of Nijmegen, The Netherlands.
Tan
Y
Y
Smits
P
P
Russel
F G
FG
van Ginneken
C A
CA
Gribnau
F W
FW
D000042:Absorption; D000293:Adolescent; D000328:Adult; D004338:Drug Combinations; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008297:Male; D014223:Triamterene / Q000493:pharmacokinetics / Q000494:pharmacology*
D004338:Drug Combinations; D005665:Furosemide; D014223:Triamterene