[Diabetes, malnutrition and growth retardation].
We investigated the cellular mechanisms responsible for growth hormone (GH) resistance in diabetes and malnutrition in the rat. In insulin-dependent diabetes, a post-receptor defect participates in GH resistance. During fasting, there is a loss of liver GH binding sites. Dietary protein restriction causes a post-receptor defect. This defect can be attributed to the combined effects of decreased liver IGF-I mRNA content and impaired message translation.
Ketelslegers
J M
JM
Unité de Diabétologie et Nutrition, Faculté de Médecine, l'Université catholique de Louvain-en-Woluwe.
Maes
M
M
Maiter
D
D
Thissen
J P
JP
Triest
S
S
Underwood
L E
LE
Lambert
A E
AE
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005215:Fasting / Q000378:metabolism; D006130:Growth Disorders / Q000378:metabolism*; D013006:Growth Hormone / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats; D011986:Receptors, Somatotropin / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism
D011986:Receptors, Somatotropin; D013002:Somatomedins; D013006:Growth Hormone
Diabète, malnutrition et retard de croissance.