In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations.
The food components chlorophyllin, beta-carotene and alpha-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa. Each of these natural protective compounds inhibited by 70-85% the clastogenic effects induced by the mutagen. When 2 or 3 of these antimutagens were administered simultaneously no additive effects were observed. alpha-Linolenic acid methyl ester was the most effective antimutagen under the experimental conditions.
Renner
H W
HW
Federal Research Centre for Nutrition, Karlsruhe, F.R.G.
D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D002734:Chlorophyll / Q000031:analogs & derivatives*; D002735:Chlorophyllides / Q000494:pharmacology*; D002869:Chromosome Aberrations; D006224:Cricetinae; D008041:Linoleic Acids / Q000494:pharmacology*; D013852:Thiotepa / Q000037:antagonists & inhibitors* / Q000633:toxicity; D019207:beta Carotene
D002735:Chlorophyllides; D008041:Linoleic Acids; D019207:beta Carotene; D002734:Chlorophyll; C005575:methyl linoleate; D002338:Carotenoids; D013852:Thiotepa; C007020:chlorophyllin