Inhibition of chlorpromazine-induced catalepsy by the 5-HT-1A ligands pindolol and buspirone in mice.
Neuroleptics such as chlorpromazine and haloperidol are capable of inducing catalepsy in rodents. Non-selective 5-hydroxytryptamine (5-HT) antagonists such as methysergide reduce the cataleptic effect of haloperidol. The present study was designed to evaluate the participation of 5-HT-1A receptors in chlorpromazine-induced catalepsy in mice. Pindolol and buspirone, two putative 5-HT-1A receptor ligands, were used. Pretreatment with these drugs reduced the cataleptic effect of chlorpromazine. Clomipramine, a 5-HT neuronal uptake blocker, reversed the inhibitory effect of buspirone. Pretreatment with clomipramine alone caused a potentiation of neuroleptic-induced catalepsy. These results suggest that central 5-HT-1A receptors play an important role in neuroleptic-induced catalepsy in mice.
Silva
S R
SR
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil.
Futuro-Neto
H A
HA
Pires
J G
JG
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D002746:Chlorpromazine / Q000037:antagonists & inhibitors*; D002997:Clomipramine / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D010869:Pindolol / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects*
D011985:Receptors, Serotonin; D010869:Pindolol; D006220:Haloperidol; D002997:Clomipramine; D002065:Buspirone; D002746:Chlorpromazine