[Study of the relations between prazosin administration schedule for patients with subacute myocardial infarction and the type of central hemodynamics based on pharmacokinetic data].
The model-independent pharmacokinetics and hemodynamics were studied in 48 patients (35 males and 13 females; mean age, 60.0 +/- 1.3 years) with primary myocardial infarction of various sites. After a single dose of 2-5 mg prazosin, the mean prazosin molecule retention time, systemic clearance and distribution were found to be substantially different from those in the groups formed by the central hemodynamic types recorded before the drug administration. The interval between the maintenance doses was recommended to be 8 hours for the hypokinetic type, 7 hours for the hypovolemic type and 6 hours for the congestive and eukinetic types. In the models with "saturated" effects it was calculated that the optimal therapeutic effect of prazosin in patients with myocardial infarction was seen in the plasma concentration range of 50-80-100 ng/ml, whose attainment required its single dose of 3-5 mg 3-4 times a day during its course monotherapy.
Petrosian
Iu R
IuR
Gofman
A M
AM
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011224:Prazosin / Q000008:administration & dosage* / Q000493:pharmacokinetics
D011224:Prazosin
Zavisimost' rezhima naznacheniia prazozina bol'nym podostrym infarktom miokarda ot tipa ikh tsentral'noĭ gemodinamiki na osnove farmakokineticheskikh dannykh.