The interaction of adenosine diphosphoribosyl transferase (ADPRT) with a cruciform DNA.
Adenosine Diphosphoribosyl Transferase is a eucaryotic nuclear protein that catalyses the transfer of ADP-ribose moiety of NAD+ to itself and other cellular proteins. DNA is required for this post-translational modification process. We present novel evidence that Adenosine Diphosphoribosyl Transferase interacts with the base of plasmid pUC7 cruciform. We speculate that, unlike a sequence-specific DNA binding protein, the transferase may recognize an unusual DNA conformation.
Sastry
S S
SS
Department of Pharmacology, School of Medicine, University of California, San Francisco 94143-0130.
Kun
E
E
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004269:DNA, Bacterial / Q000378:metabolism; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010957:Plasmids; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011485:Protein Binding; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D013950:Thymus Gland / Q000201:enzymology
D004269:DNA, Bacterial; D011065:Poly(ADP-ribose) Polymerases