title: Specific responses to two unrelated antigens in mice made orally tolerant to one of them.
abstract: BDF1 and B10 mice, either normal or exclusively fed egg white diluted in water, were immunized with ovalbumin (OVA), sheep erythrocytes (SRBC) or OVA + SRBC. BDF1, but not B10, mice became tolerant to OVA and presented a 100% increase in the total number of immunoglobulin-secreting cells in the spleen. Immunization with OVA + SRBC markedly increased the response to OVA, except in tolerant BDF1 mice, and had no effect on the anti-SRBC PFC response, except in normal (non-tolerant) BDF1 mice.
authors.affiliation: Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
authors.forename: C R
authors.initials: CR
authors.lastname: Carvalho
authors.forename: N M
authors.initials: NM
authors.lastname: Vaz
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
chemical_list: D010047:Ovalbumin