title: Plasma free N-terminal fibronectin 30-kDa domain as a marker of endothelial dysfunction in type 1 diabetes mellitus.
abstract: The plasma free N-terminal fibronectin 30-kDa domain was measured in 44 type 1 diabetic patients and in 20 healthy subjects. A significantly raised mean concentration of a free N-terminal fibronectin 30-kDa domain was found in plasma of diabetic patients with proliferative retinopathy as compared with healthy persons (P less than 0.001). A positive correlation was observed between free N-terminal fibronectin 30-kDa domain and von Willebrand factor in plasma of all examined subjects (r = 0.62, P less than 0.01). A similar correlation was present between 30-kDa domain and albuminuria (r = 0.56, P less than 0.01). However, no relationship was found between fibronectin 30-kDa domain and control of diabetes as assessed by fructosamine concentration. The free N-terminal fibronectin 30-kDa domain may be used as a marker of actual endothelial cell dysfunction in diabetes.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Skrha
authors.forename: I
authors.initials: I
authors.lastname: Vacková
authors.forename: J
authors.initials: J
authors.lastname: Kvasnicka
authors.forename: V
authors.initials: V
authors.lastname: Stibor
authors.forename: P
authors.initials: P
authors.lastname: Stolba
authors.forename: H
authors.initials: H
authors.lastname: Richter
authors.forename: H
authors.initials: H
authors.lastname: Hörmann
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D015415:Biomarkers; D005353:Fibronectins; D010446:Peptide Fragments