Evidence that endogenous gamma interferon is produced early in Listeria monocytogenes infection.
It has been presumed that gamma interferon (IFN-gamma), which plays an essential role in antilisterial resistance, is produced late in Listeria monocytogenes infection. In the present study, however, IFN-gamma was detected in the bloodstreams and spleens of mice from days 1 to 4 of L. monocytogenes infection by both a double-sandwich enzyme-linked immunosorbent assay and an immunohistochemical technique, suggesting that endogenous IFN-gamma is produced early but not late in L. monocytogenes infection.
Nakane
A
A
Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.
Numata
A
A
Asano
M
M
Kohanawa
M
M
Chen
Y
Y
Minagawa
T
T
D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology*; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013997:Time Factors
D007371:Interferon-gamma