Association of neutrophil alkaline phosphatase activity and glycosylated haemoglobin in diabetes mellitus.
We determined neutrophil alkaline phosphatase (NAP) activity in diabetic patients in conjunction with HbA1c levels. NAP was estimated using semiquantitative cytochemical technique, and we studied its activity in different groups of diabetic patients. We found that NAP score is correlated with the HbA1c level. Non-diabetic patients were used as controls, in whom NAP score and HbA1c were found normal. In diabetic patients the NAP activity and the HbA1c level were altered similarly during the various phases of the disease. Our findings indicate that NAP score could be used as a simple new parameter for diabetes. The pathophysiologic mechanism of our observations needs further investigation.
Tsavaris
N B
NB
Second Department of Internal Medicine-Propaedeutic Evangelisomos Hospital, University of Athens School of Medicine, Greece.
Pangalis
G A
GA
Variami
E
E
Karabelis
A
A
Kosmidis
P
P
Raptis
S
S
D000469:Alkaline Phosphatase / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005215:Fasting / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D009504:Neutrophils / Q000201:enzymology*; D012016:Reference Values
D000469:Alkaline Phosphatase; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin