[The effect of insulin on the lipid composition of the erythrocyte membranes of diabetics].
A study is presented of the dynamics of components of lipid spectrum of erythrocytic membrane in insulin-dependent type of diabetes mellitus against the background of traditional types of treatment (Porcine insulin and insulin-zinc-suspension) and use of monospike and monocomponent insulins. Insulins of high purity were found to produce a normalizing effect on the disturbances of the lipid composition. Thus, cholesterol indices normalized in 2-3 months. The level of general phospholipids and dien conjugates improved as well. The changes were accompanied by positive changes in the fraction ratio of phospholipids while disorders of the fraction of phosphatidylcholine remained abnormal and low values phosphatidylinosite were registered.
Kozlov
G S
GS
Buĭdina
T A
TA
Pribytkov
Iu N
IuN
D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D013535:Suspensions; D015032:Zinc / Q000627:therapeutic use
D007328:Insulin; D008563:Membrane Lipids; D013535:Suspensions; D015032:Zinc
Vliianie insulina na lipidnyĭ sostav membrany éritrotsitov bol'nykh sakharnym diabetom.