title: Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid-liquid extraction.
abstract: Benzalkonium chloride was assayed by on-line extraction of the benzalkonium ion with picrate to chloroform. The absorbance of picrate was measured. The extractions were performed with a home-made flow injection extraction unit. Calibration curves (1.5-180 x 10(-4)% w/v) were straight lines (r = 0.9993) and the relative standard deviation of a series of injections was less than or equal to 2%. Pharmaceutical benzalkonium preparations, containing xylometazoline, timolol, phenylephrine or carbachol could also be assayed. The method was compared with a modified HPLC assay.
authors.affiliation: Utrecht University, Department of Pharmaceutical Analysis, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Halvax
authors.forename: G
authors.initials: G
authors.lastname: Wiese
authors.forename: J A
authors.initials: JA
authors.lastname: Arp
authors.forename: J M
authors.initials: JM
authors.lastname: Vermeer
authors.forename: W P
authors.initials: WP
authors.lastname: van Bennekom
authors.forename: A
authors.initials: A
authors.lastname: Bult
mesh_terms: D001548:Benzalkonium Compounds / Q000032:analysis*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid
chemical_list: D001548:Benzalkonium Compounds