Identification of an octamer-binding site in the human kappa light-chain enhancer.
Octamer motifs contribute to the function and tissue specificity of immunoglobulin heavy- and light-chain gene promoters and the heavy-chain enhancer. A variant octamer-binding site within a conserved region of the human kappa light-chain gene enhancer which contributes to the function of this enhancer has been identified.
Nelms
K
K
Institute of Human Genetics, University of Minnesota, Minneapolis 55455.
Van Ness
B
B
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D001665:Binding Sites; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004742:Enhancer Elements, Genetic; D015321:Gene Rearrangement; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism; D015345:Oligonucleotide Probes; D011401:Promoter Regions, Genetic; D012689:Sequence Homology, Nucleic Acid; D014162:Transfection
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D009687:Nuclear Proteins; D015345:Oligonucleotide Probes; D015500:Chloramphenicol O-Acetyltransferase