title: Total parenteral nutrition associated cholestasis: a predisposing factor for sepsis in surgical neonates?
abstract: Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 of them and 12 of these patients developed sepsis. In contrast, of the 79 patients on TPN that remained free from cholestasis, only 23 developed sepsis. The mortality rate for the TPNAC-group was substantially higher than for the group without TPNAC. It is suggested that development of TPNAC might lead to impairment of non-specific cellular immunity in neonates.
authors.affiliation: Department of Paediatric Surgery, Sophia Children's Hospital, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: A P
authors.initials: AP
authors.lastname: Bos
authors.forename: D
authors.initials: D
authors.lastname: Tibboel
authors.forename: F W
authors.initials: FW
authors.lastname: Hazebroek
authors.forename: J H
authors.initials: JH
authors.lastname: Bergmeijer
authors.forename: E J
authors.initials: EJ
authors.lastname: van Kalsbeek
authors.forename: J C
authors.initials: JC
authors.lastname: Molenaar
mesh_terms: D001424:Bacterial Infections / Q000209:etiology*; D002779:Cholestasis / Q000150:complications / Q000209:etiology*; D004065:Digestive System Abnormalities; D013505:Digestive System Surgical Procedures; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D018805:Sepsis / Q000209:etiology*