The interaction of the benzimidazole dye Hoechst 8208 with nucleic acids.
The interaction of Hoechst 8208 (H8208) with DNA and synthetic polynucleotides has been studied by absorption, fluorescence, flow dichroism, circular dichroism (CD), and viscosity measurements. The results are compatible with an intercalative mode of H8208 binding.
Nakamura
H
H
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Hifumi
H
H
Kubota
Y
Y
D000814:Aniline Compounds / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D004396:Coloring Agents / Q000737:chemistry*; D004247:DNA / Q000187:drug effects*; D005453:Fluorescence; D009841:Oligonucleotides / Q000737:chemistry*; D013057:Spectrum Analysis; D014783:Viscosity
D000814:Aniline Compounds; D001562:Benzimidazoles; D004396:Coloring Agents; D009841:Oligonucleotides; C023989:H8208; D004247:DNA