Osteoporosis and diabetes: lessons from the diabetic BB rat.
The spontaneously diabetic BB rat was used to study the effect of diabetes on bone. Short-term diabetes (3-4 weeks) resulted in a state of low bone turnover, characterized by a severe decrease in osteoblast/osteoid surface and bone mineral apposition rate on histology, and in serum osteocalcin concentrations. If diabetes was long-term (12 weeks), the parameters of low bone formation were associated with histological evidence of osteoporosis and a decreased bone strength; the relative bone calcium concentration remained normal in diabetes. We conclude that long-standing diabetes results in a low-turnover osteoporosis.
Verhaeghe
J
J
Laboratory of Experimental Medicine and Endocrinology, K.U. Leuven, Belgium.
Visser
W J
WJ
Einhorn
T A
TA
Bouillon
R
R
D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000209:etiology*; D051381:Rats; D011913:Rats, Inbred BB; D013977:Tibia / Q000473:pathology
D015675:Osteocalcin