title: [New valvular homografts. Prospects and limits of their viability. Report of 42 implantations].
abstract: The regain of interest in aortic homograft bioprostheses is related to the prospects of improved viability resulting from explanation from organ donors, preservation in rich tissue culture media, together with the progress made in techniques of cryopreservation. Viability studies examining morphology of electron microscopy and tests of tissue culture confirm this notion of longer viability. These properties raise hopes of satisfactory long-term results while acknowledging outstanding antigenic problems which require strict A-B-O system compatibility. The results of a preliminary series of 42 valve homografts implanted at Henri Mondor Hospital over the last 5 years are reported. Twenty-one bioprostheses were implanted on the right side in congenital heart disease with good results in every case. Twenty-one were implanted in the aortic position in children and show no signs of degeneration as yet. One poor result was related to a technical error in calibration. The rebirth of this technique raises certain hopes, especially in aortic valve replacement.
authors.affiliation: Service de chirurgie thoracique et cardiovasculaire, CHU Henri-Mondor, Créteil.
authors.forename: G
authors.initials: G
authors.lastname: Bloch
authors.forename: P
authors.initials: P
authors.lastname: Mesnildrey
authors.forename: M C
authors.initials: MC
authors.lastname: Hanotel
authors.forename: Y
authors.initials: Y
authors.lastname: Heurtematte
authors.forename: J P
authors.initials: JP
authors.lastname: Cachera
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: A
authors.initials: A
authors.lastname: Astier
authors.forename: F
authors.initials: F
authors.lastname: Beaujean
authors.forename: L
authors.initials: L
authors.lastname: Dubertret
authors.forename: P
authors.initials: P
authors.lastname: Galle
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve; D002470:Cell Survival; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D005347:Fibroblasts; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000379:methods*; D006801:Humans; D008297:Male; D011664:Pulmonary Valve; D014184:Transplantation, Homologous
vernacular_title: Les nouvelles homogreffes valvulaires. Espoirs et contraintes de leur viabilité. A propos de 42 implantations d'homogreffes.