lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.
The T-lymphocyte-specific tyrosine kinase gene, lck, is expressed in T-lymphocyte cell lines, except for several human T-cell leukemia virus type I(HTLV-I)-transformed T-lymphocyte cell lines, which produce HTLV-I. By introducing an lck-expression vector, we found that lck product suppresses gene expression from HTLV-I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by lck.
Ohta
M
M
Virology Division, National Cancer Center Research Institute, Tokyo.
Morita
T
T
Shimotohno
K
K
D015500:Chloramphenicol O-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics*; D004790:Enzyme Induction; D015967:Gene Expression Regulation, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D013489:Suppression, Genetic; D014162:Transfection
D015500:Chloramphenicol O-Acetyltransferase; D011505:Protein-Tyrosine Kinases; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)