title: An online technique for estimating cerebral carbon dioxide reactivity.
abstract: A technique for measuring cerebral reactivity using transcranial pulsed Doppler ultrasound is described; the system includes a spectrum analyser and capnometer. Data acquisition and manipulation is under software control. Main stem middle cerebral artery blood velocity is monitored continuously using the transcranial Doppler technique, whilst the operator initiates data collection and controls the inspired gas composition. The calculation of cerebral CO2 reactivity is based upon linear regression analysis of normalized, time-averaged middle cerebral velocity on end-tidal pCO2 and is displayed graphically. Measurement of middle cerebral CO2 reactivities can be completed within 15 min. Results from two subjects, a healthy volunteer and a patient with occlusive disease, are shown to illustrate the technique.
authors.affiliation: Division of Radiological Sciences, Guys Hospital, London, UK.
authors.forename: M C
authors.initials: MC
authors.lastname: Patel
authors.forename: M G
authors.initials: MG
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Kontis
authors.forename: T S
authors.initials: TS
authors.lastname: Padayachee
authors.forename: R G
authors.initials: RG
authors.lastname: Gosling
mesh_terms: D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000097:blood / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004562:Electrocardiography; D001330:Electronic Data Processing; D006801:Humans; D008838:Microcomputers; D009862:Online Systems; D012016:Reference Values; D012984:Software; D012985:Software Design; D014463:Ultrasonography / Q000379:methods*
chemical_list: D002245:Carbon Dioxide