title: Experimental study of a newly developed bilayer artificial skin.
abstract: A bilayer artificial skin composed of an outer layer of silicone polymer and an inner sponge layer of collagen containing chondroitin 6-sulphate was developed by modifying the technique proposed by Yannas et al. The artificial skin was placed on the skin defects on the backs of rats. Histological observation indicated that fibroblasts and capillaries infiltrated into the pores and filled in lattice spaces, resulting in synthesis of the connective tissue matrix and absorption of the original network of collagen and chondroitin 6-sulphate. Epidermal cells migrated from the edge of the wound between the two layers. Post-operative contracture in the wound with the artificial skin was significantly less than in the control.
authors.affiliation: Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Isshiki
authors.forename: Y
authors.initials: Y
authors.lastname: Tamada
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials; D002809:Chondroitin Sulfates; D003094:Collagen; D003286:Contracture / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012828:Silicones; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D012828:Silicones; D002809:Chondroitin Sulfates; D003094:Collagen