Use of sodium aurothiomalate during lactation.
The report concerns a mother who breast fed her infant whilst receiving sodium aurothiomalate for the treatment of rheumatoid arthritis. The milk:serum concentration ratio was not constant, reflecting the non-concurrence of the concentration-time profiles of gold in milk and maternal serum after i.m. injection. Gold was detected in the infant's serum. Calculations indicate that the weight-adjusted dose to the infant exceeded that received by the mother.
Bennett
P N
PN
Clinical Pharmacology Unit, Royal United Hospital, Bath, Avon.
Humphries
S J
SJ
Osborne
J P
JP
Clarke
A K
AK
Taylor
A
A
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006046:Gold / Q000097:blood / Q000378:metabolism; D006052:Gold Sodium Thiomalate / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007774:Lactation; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy
D006052:Gold Sodium Thiomalate; D006046:Gold