title: [Exponential analysis of the relationship between ST segment depression and heart rate during exercise in patients with ischemic cardiopathy].
abstract: ST segment displacement sensitivity and specificity during exercise in the detection of myocardial ischemia are controversial, even when using mathematical approaches such as a linear regression analysis of ST/heart rate slope. In an attempt to see whether an exponential fit (ST = A-B*exp (-K*RR] of ST/heart rate relation during exercise could increase the diagnostic accuracy of exercise test in the detection of myocardial ischemia, we studied 165 patients (141 men and 24 women, mean age: 56 +/- 10 years) undergoing a simultaneous radionuclide assessment of regional ventricular function and myocardial perfusion at rest and at peak exercise in 4 hours by means of 2 injections of 99mTc-MIBI. Normal radionuclide findings were found in 4 subjects, whereas exercise-induced myocardial ischemia was detected in 90 patients with no evidence of previous myocardial infarction, and in 71 patients with previous myocardial infarction. ST segment depression was present at peak exercise in no normal subject, and in 52.2% and 60.4% of ischemic and infarcted patients, respectively, achieving a sensitivity of 55.9%, a specificity of 100% and a diagnostic accuracy of 57%. A, B and K coefficients of exponential analysis showed a wide variability among patients; however, the algebraic sign of K coefficient was negative in 50% of normal subjects versus 9.9% of patients (chi 2-test: p less than 0.02), thus achieving a sensitivity of 90.1%, a specificity of 50% and a diagnostic accuracy of 89.1% in the detection of exercise-induced myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: II Cattedra di Malattie dell'Apparato Cardiovascolare, Università degli Studi La Sapienza, Roma.
authors.forename: M
authors.initials: M
authors.lastname: Ciavolella
authors.forename: F
authors.initials: F
authors.lastname: Monti
authors.forename: P E
authors.initials: PE
authors.lastname: Puddu
authors.forename: C
authors.initials: C
authors.lastname: Giannitti
authors.forename: D
authors.initials: D
authors.lastname: Scali
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
vernacular_title: Analisi esponenziale del rapporto fra sottolivellamento del tratto ST e frequenza cardiaca durante sforzo in pazienti con cardiopatia ischemica.