IVF pregnancy after induction of an ovulatory endogenous gonadotrophin surge using an LHRH agonist nasal spray.
A successful human twin IVF pregnancy is reported after using a single 50 micrograms dose of LHRH agonist nasal spray (Buserelin) to induce an ovulatory endogenous gonadotrophin surge 34 h prior to oocyte collection. The couple had 10 years of primary male factor infertility, associated with significant anti-sperm antibodies. The clinical features and endocrine profile are presented.
Bentick
B
B
Academic Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
Shaw
R W
RW
Iffland
C A
CA
Burford
G
G
Bernard
A
A
D000281:Administration, Intranasal; D000328:Adult; D015551:Autoimmunity; D002064:Buserelin / Q000008:administration & dosage / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000276:immunology / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013094:Spermatozoa / Q000276:immunology; D014427:Twins
D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin