Absorption of ciprofloxacin administered through a nasogastric or a nasoduodenal tube in volunteers and patients receiving enteral nutrition.
The absorption of ciprofloxacin was higher when administered through a nasoduodenal tube than through a nasogastric tube, indicating that even though acidic gastric pH is needed for rapid disintegration, dissolved ciprofloxacin might not be stable in the gastric environment. If the length of exposure or the different gastric environment in each individual affects the overall absorption of ciprofloxacin, this could explain the reported variability in ciprofloxacin absorption and suggests the need for the development of an enteric-coated tablet. Further studies are needed to fully characterize the absorption of ciprofloxacin in patients with different illnesses, gastric transit times, gastrointestinal environments and of different ages.
Yuk
J H
JH
Department of Pharmacy, Hartford Hospital, CT 06115.
Nightingale
C H
CH
Quintiliani
R
R
Yeston
N S
NS
Orlando
R
R
Dobkin
E D
ED
Kambe
J C
JC
Sweeney
K R
KR
Buonpane
E A
EA
D000042:Absorption; D000368:Aged; D001682:Biological Availability; D001835:Body Weight; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004750:Enteral Nutrition; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged
D002939:Ciprofloxacin