title: Derivatives of (R,S)-1-N-(theophyllinyl-7'-ethyl)-amino-2-propanol with antiarrhythmic activity.
abstract: Three (R,S)-1-N-(theophyllinyl-7'-ethyl)-amino-2-propanol derivatives were obtained as soluble hydrochlorides and tested in four models of experimental arrhythmia. Two compounds 1a and 2 have shown antiarrhythmic properties and very low toxicity.
authors.affiliation: Department of Chemical Technology of Drugs, Copernicus Medical Academy, Kraków, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Eckstein
authors.forename: J
authors.initials: J
authors.lastname: Zajaczkowska
authors.forename: L
authors.initials: L
authors.lastname: Samochowiec
authors.forename: M
authors.initials: M
authors.lastname: Maksjan
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives*
chemical_list: D000889:Anti-Arrhythmia Agents; D013806:Theophylline