[Autoantibodies to 5 types of collagen in patients with circumscribed scleroderma].
Elevated levels of autoantibodies to types I-V collagens were detected in local scleroderma patients. In 75 percent of cases the levels of autoantibodies to types I and III collagens were elevated, in 30 percent to type II collagens, in 25 percent to type IV collagens, and in 20 percent to type V collagens. Anticollagen autoantibody levels did not differ from the normal values in the patients with a prolonged (for more than a year) remission. A reduction of these antibody levels almost to the normal values was achieved in 10-12 months after tigason therapy during a prolonged clinical remission. The ratio between autoantibodies to types I and II collagens was found to be a constant both in the donors and patients with local scleroderma.
Samsonov
V A
VA
Gareginian
S A
SA
Polevaia
O Iu
OIu
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002908:Chronic Disease; D003094:Collagen / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000276:immunology*
D001323:Autoantibodies; D003094:Collagen
Autoantitela k kollagenam 5 tipov u bol'nykh ogranichennoĭ sklerodermieĭ.