title: Signal transduction for chemotaxis in Dictyostelium amoebae.
abstract: The signal for chemotaxis in D. discoideum is cyclic AMP. This molecule binds to cell surface receptors and triggers the production of inositol (1,4,5)trisphosphate which releases Ca2+ from non-mitochondrial stores. The subsequent chain of signal transduction events brings about the polymerization of cytoskeletal actin (associated with pseudopodium formation) within five seconds and the formation of a peak of cyclic GMP within 10 s. Evidence from streamer F mutants indicates that the cyclic GMP regulates the association of myosin with the cytoskeleton that occurs at 25-50 s and that this phenomenon is concerned with elongation of the amoebae during chemotactic movement.
authors.affiliation: Department of Biochemistry, University of Oxford, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Newell
authors.forename: G N
authors.initials: GN
authors.lastname: Europe-Finner
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Gammon
authors.forename: C A
authors.initials: CA
authors.lastname: Wood
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002633:Chemotaxis / Q000502:physiology*; D003599:Cytoskeleton / Q000737:chemistry; D004023:Dictyostelium / Q000502:physiology*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium