[Use of monoclonal antibodies for studying cytochrome P-450 forms. Use of interspecies homology of amino acid sequence].
The current research on utilization of monoclonal antibodies for isolation of cytochrome P-450 forms, substrate specificity determination, localization in tissues and contribution in DNA adduct formation is reviewed in this paper. Usefulness of monoclonal antibodies directed against rodent cytochrome P-450 isoenzymes to human investigations is emphasized.
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Zakładu Genetyki Człowieka, Polskiej Akademii Nauk w Poznaniu.
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D000595:Amino Acid Sequence / Q000235:genetics; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D000911:Antibodies, Monoclonal; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D005796:Genes / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D011817:Rabbits; D051381:Rats
D000596:Amino Acids; D000911:Antibodies, Monoclonal; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System
Zastosowanie przeciwciał monoklonalnych do oznaczania odmian cytochromów P-450. Wykorzystanie miedzygatunkowych homologii sekwencji aminokwasów.