title: Influence of pH adjustment agents on the biologic behavior of osmium-191 impurity in iridium-191m generator eluates.
abstract: The influence of four pH adjustment agents on the biologic behavior of osmium-191 (191Os) impurity in 191Os/191mIr generator eluates was studied. Extended body clearance and biodistribution studies were performed in mice. The solutions to be injected were obtained by eluting generators with a 0.9% NaCl solution at pH 1. The pH of these eluates was adjusted to 5-9 with succinate, phosphate, lysine or NaOH solution. Our results demonstrate that the biologic behavior of these generator eluates is significantly dependent on the agent used for pH adjustment. Buffering with lysine leads to the best results: (a) the mice show no adverse reaction after injection of 150 human doses and the body clearance is very rapid and (b) more than 75% I.D. at 24 hr postinjection. Preliminary calculations based on these results suggest a significant decrease in the estimated patient radiation dose when lysine buffered 191Os/191mIr generator eluates are used for radionuclide angiography.
authors.affiliation: Radiopharmaceutical Department, Soreq Nuclear Research Center, Yavne, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Weininger
authors.forename: D
authors.initials: D
authors.lastname: Issachar
authors.forename: E
authors.initials: E
authors.lastname: Lubin
authors.forename: M
authors.initials: M
authors.lastname: Zabari
authors.forename: J
authors.initials: J
authors.lastname: Trumper
mesh_terms: D000818:Animals; D002021:Buffers; D006863:Hydrogen-Ion Concentration; D007495:Iridium; D007554:Isotopes; D008239:Lysine / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009992:Osmium / Q000493:pharmacokinetics; D010710:Phosphates / Q000494:pharmacology; D011868:Radioisotopes; D011876:Radionuclide Generators; D012972:Sodium Hydroxide / Q000494:pharmacology; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid; D014018:Tissue Distribution
chemical_list: D002021:Buffers; D007554:Isotopes; D010710:Phosphates; D011868:Radioisotopes; D013386:Succinates; D009992:Osmium; D007495:Iridium; D012972:Sodium Hydroxide; D019802:Succinic Acid; D008239:Lysine; C018279:sodium phosphate