title: Clinical evaluation of a new bilayer "artificial skin" composed of collagen sponge and silicone layer.
abstract: A bilayer "artificial skin" composed of an outer layer of silicone and an inner sponge layer of collagen and chondroitin sulphate has been developed by modifying the technique proposed by Yannas et al. (1980). Following experimental successes, the "artificial skin" was applied clinically. It was placed on the skin defects of 10 patients. Three weeks after application the outer layer of silicone sheet was peeled off and thin split thickness skin was grafted onto the newly synthesised dermis-like tissue. Secondary skin grafts took perfectly in all cases and postoperative appearance was satisfactory.
authors.affiliation: Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Isshiki
authors.forename: Y
authors.initials: Y
authors.lastname: Tamada
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000293:Adolescent; D000328:Adult; D001187:Artificial Organs; D001424:Bacterial Infections / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002809:Chondroitin Sulfates; D003094:Collagen; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000601:surgery; D012828:Silicones; D012867:Skin; D012878:Skin Neoplasms / Q000601:surgery; D016038:Skin Transplantation; D013524:Surgical Flaps
chemical_list: D012828:Silicones; D002809:Chondroitin Sulfates; D003094:Collagen