title: [Studies on the active constituents of Momordica charantia L].
abstract: Five compounds were isolated from the seeds of Momordica charantia. This paper reports their structure determination by spectral (IR, UV, HNMR, CNMR, and MS) and chemical methods. The structures of I, II, III, IV and V were elucidated as vacine, mycose, 3-O-(beta-D-glucopyranosyl)-24 beta-ethyl-5 alpha-cholesta-7, trans-22E, 25 (27)-trien-3 beta-ol, momorcharaside A and momorcharaside B respectively. Mycose was the first time found in this plant and compound III was the first time found in the genus Momordica. IV and V were new compounds. IV exhibited obvious inhibition of DNA and RNA syntheses in S 180 tumor cells in preliminary pharmacological studies.
authors.affiliation: Sichuan Institute of Chinese Materia Medica, Chongqing.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Zhu
authors.forename: Z C
authors.initials: ZC
authors.lastname: Zhong
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Luo
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007810:Lanosterol; D010946:Plants, Medicinal / Q000032:analysis*; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012510:Sarcoma 180 / Q000473:pathology; D012639:Seeds / Q000032:analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012334:RNA, Neoplasm; D014315:Triterpenes; C070692:momorcharaside B; C070691:momorcharaside A; D007810:Lanosterol