Hepatic bilirubin and UDP-glucuronate levels in Bolivian squirrel monkeys exhibiting fasting hyperbilirubinemia.
1. Bolivian squirrel monkeys (BoSMs), which are animal models for Gilbert's syndrome, have 40% less hepatic bilirubin UDP-glucuronyltransferase (BR-UPPG-T) activity than Brazilian squirrel monkeys (BrSMs). 2. Although fasting results in similar decreases in hepatic UDP-glucose and UDP-glucuronate levels in both simian subspecies, increased activities (55%) of BR-UDPG-T are induced only in the fasted control BrSMs, which do not exhibit the marked fasting hyperbilirubinemia (FH). 3. Total hepatic bilirubin (BR) concentrations were 50% greater in both fed and fasted BoSMs when compared to BrSMs. 4. Hepatic unconjugated BR levels increase upon fasting only in Gilbert-like BoSMs, reaching concentrations twice that observed in BrSMs. 5. Elevated hepatic BR levels in fasted BoSMs may reflect BR overproduction or inadequate glucuronidation. 6. The increased BR-UDPG-T activity induced in BrSMs during fasting could compensate in-part for the UDPGA depletion and prevent the marked FH as observed in BoSMs.
Myers
B A
BA
California Primate Research Center, Davis.
Lawton
M P
MP
Ruegg
C L
CL
Bruss
M L
ML
Cornelius
C E
CE
D000818:Animals; D001663:Bilirubin / Q000097:blood / Q000378:metabolism*; D005215:Fasting; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006932:Hyperbilirubinemia / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D012453:Saimiri; D014532:Uridine Diphosphate Glucose / Q000378:metabolism; D014535:Uridine Diphosphate Glucuronic Acid / Q000097:blood / Q000378:metabolism*; D014539:Uridine Diphosphate Sugars / Q000378:metabolism*
D014539:Uridine Diphosphate Sugars; D014535:Uridine Diphosphate Glucuronic Acid; D006003:Glycogen; D014453:Glucuronosyltransferase; D001663:Bilirubin; D014532:Uridine Diphosphate Glucose