title: [Pure red cell aplasia in chronic lymphatic leukemia. Successful treatment using immunosuppression].
abstract: The authors describe two cases of chronic lympocytic leukaemia complicated by pure red cell aplasia of autoimmune origin. The first patient achieved complete recovery of erythropoiesis after short-term immunosuppression by means of cyclophosphamide and prednisone. The second patient did not respond to the same combination of immunosuppressive drugs and remission was achieved by administration of antithymocyte globulin. In the discussion the authors deal with contemporary knowledge of the pathogenesis of autoimmune erythroblastopenia and mechanismus of action of antithymocyte globulin.
authors.affiliation: I. interní klinika fakultní nemocnice KUNZ, Plzen.
authors.forename: M
authors.initials: M
authors.lastname: Svojgrová
authors.forename: J
authors.initials: J
authors.lastname: Slechtová
authors.forename: V
authors.initials: V
authors.lastname: Koza
authors.forename: P
authors.initials: P
authors.lastname: Panzner
authors.forename: V
authors.initials: V
authors.lastname: Cepelák
mesh_terms: D000368:Aged; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000628:therapy*; D013601:T-Lymphocytes
chemical_list: D000961:Antilymphocyte Serum; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Cistá aplázie erythropoézy u chronické lymfatické leukémie. Uspĕsná lécba imunosupresí.