title: Midazolam and flumazenil in the anaesthetic management of trigeminal nerve thermocoagulation.
abstract: A technique is described for the anaesthetic management of trigeminal nerve thermocoagulation by administration of repeated doses of midazolam and flumazenil. "Wake-up" times after administration of flumazenil in 20 patients were shorter than those reported during spontaneous recovery from methohexitone or propofol anaesthesia. The midazolam dose required for a second phase of sedation after antagonism of the first with flumazenil was significantly less than that for the first phase of sedation. There was no evidence of postoperative resedation. Reversal of sedation was associated with an increase in arterial pressure.
authors.affiliation: Department of Anaesthesia, National Hospital for Nervous Diseases, London.
authors.forename: A W
authors.initials: AW
authors.lastname: Harrop-Griffiths
authors.forename: N A
authors.initials: NA
authors.lastname: Watson
authors.forename: D A
authors.initials: DA
authors.lastname: Jewkes
mesh_terms: D015760:Alfentanil / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D004564:Electrocoagulation; D005425:Flicker Fusion / Q000187:drug effects; D005442:Flumazenil / Q000008:administration & dosage* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D013997:Time Factors; D014276:Trigeminal Nerve / Q000601:surgery; D014277:Trigeminal Neuralgia / Q000601:surgery*
chemical_list: D015760:Alfentanil; D005442:Flumazenil; D008874:Midazolam