title: Electrophoretic characterizations of cross-linked fibrinogen derivatives in blood and vascular tissue by zonal immobilization on glyoxyl agarose.
abstract: Direct immunoprobing of electrophoregrams of plasma and intimal protein on glyoxyl agarose and composite-gels with polyacrylamide have uncovered novel modes of cross-linking of fibrinogen that differ from those previously characterized. These modes of cross-linking involve the A alpha-chains of fibrinogen and hybrid cross-linking of alpha- and gamma-chains.
authors.affiliation: Research Institute of the Cleveland Clinic Foundation, OH 44195.
authors.forename: J R
authors.initials: JR
authors.lastname: Shainoff
authors.forename: R
authors.initials: R
authors.lastname: Valenzuela
authors.forename: R
authors.initials: R
authors.lastname: Graor
authors.forename: D A
authors.initials: DA
authors.lastname: Urbanic
authors.forename: P M
authors.initials: PM
authors.lastname: DiBello
mesh_terms: D004587:Electrophoresis, Agar Gel / Q000379:methods; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000302:isolation & purification; D006038:Glyoxylates; D006801:Humans; D007202:Indicators and Reagents; D046911:Macromolecular Substances; D012685:Sepharose; D014652:Vascular Diseases / Q000097:blood*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D006038:Glyoxylates; D007202:Indicators and Reagents; D046911:Macromolecular Substances; C070399:glyoxyl agarose; D005340:Fibrinogen; D012685:Sepharose