title: The electrocardiographic changes in a case of flecainide overdose.
abstract: Flecainide acetate is a new potent class I antiarrhythmic agent. We report serial electrocardiographic changes occurring in a case of flecainide overdose. The initial flecainide serum level was three times greater than the upper therapeutic level. The prolonged electrocardiographic time intervals (PR and QRS) decreased in correlation with falling drug levels. As the case was associated with concomitant alcohol intoxication, we speculate about the protective effect of alcohol in order to explain our patient's benign clinical course.
authors.affiliation: Griffin Hospital, Derby.
authors.forename: P K
authors.initials: PK
authors.lastname: Chung
authors.forename: P
authors.initials: P
authors.lastname: Tuso
mesh_terms: D000328:Adult; D062787:Drug Overdose; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D005424:Flecainide / Q000097:blood / Q000506:poisoning*; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans
chemical_list: D005424:Flecainide