[Buspirone: correlation of its anxiolytic and electroencephalographic effects].
The influence of diazepam (1 and 5 mg/kg, i. p.) and buspirone (5 and 10 mg/kg) on the Fourier's spectral EEG power of sensomotor cortex and a conflict behavior in freely moving rats were studied. Diazepam (1 mg/kg) and buspirone (5 mg/kg) produced slowing of EEG theta-activity. Large doses of diazepam and buspirone produced different and multiple EEG effects. To 15-1788 (10 mg/kg) completely antagonized all the effects of diazepam (5 mg/kg). The authors discuss possible mutual relations between the influence on EEG and anxiolytic effect of these tranquilizers.
Bogdanov
N N
NN
Voronina
T A
TA
Molodavkin
G M
GM
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005442:Flumazenil / Q000494:pharmacology; D005583:Fourier Analysis; D008297:Male; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects; D013997:Time Factors
D005442:Flumazenil; D003975:Diazepam; D002065:Buspirone
Buspiron: korreliatsii mezhdu anksioliticheskimi i élektroéntsefalograficheskimi éffektami.