title: A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.
abstract: A human cDNA encoding a novel protein in the helix-loop-helix family has been isolated by screening a bacteriophage expression library with a probe containing the binding site for major late transcription factor. The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
authors.affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: C S
authors.initials: CS
authors.lastname: Carr
authors.forename: P A
authors.initials: PA
authors.lastname: Sharp
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D006801:Humans; D015151:Immunoblotting; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008222:Lymphokines / Q000235:genetics*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D029584:Prostatic Secretory Proteins; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D008222:Lymphokines; D009363:Neoplasm Proteins; D029584:Prostatic Secretory Proteins; C064972:TFEB protein, human; D014157:Transcription Factors; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D004247:DNA