The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections.
In an open study, continuous oral therapy with cyclooxygenase inhibitors (ibuprofen or indomethacin) reduced the incidence and frequency of recurrent eruptions in nine of 16 patients with herpes simplex virus infection. Retrospective analysis of seven cases indicated that natural killer cell enhancement assays might allow us to predict the clinical outcome of such treatment.
Wachsman
M
M
Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore.
Aurelian
L
L
Burnett
J W
JW
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors; D005260:Female; D006561:Herpes Simplex / Q000517:prevention & control*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D015994:Incidence; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012008:Recurrence
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007052:Ibuprofen; D007213:Indomethacin