title: Possible typhus-group infection in New York State: presentation of four suspect cases.
abstract: Epidemiologic investigations were recently conducted on four cases which were reported in New York State in 1986 and 1987, three of which were within one family. These included hospital chart reviews, case or family interviews, animal trappings, and ectoparasite surveys. Serologic tests and immunoblots were performed on blood samples obtained from these patients. All four patients had acute febrile illnesses; two required hospitalization and one died. Microimmunofluorescence test results using Rickettsia typhi and R. prowazekii antigens showed a greater than or equal to 4-fold increase in titer with paired sera from three patients. The remaining patient had a single serum titer of 4096 with both antigens. In addition, sera from all patients reacted with R. typhi in the immunoblot test and, from the three patients for whom sera were available, also with R. prowazekii. Results suggest that the four patients were exposed to the typhus-group rickettsiae or to an organism which shares a common epitope(s).
authors.affiliation: Bureau of Communicable Disease Control, New York State Department of Health, Albany 12237.
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: P F
authors.initials: PF
authors.lastname: Smith
authors.forename: K E
authors.initials: KE
authors.lastname: Hechemy
authors.forename: M E
authors.initials: ME
authors.lastname: Veltman
authors.forename: R
authors.initials: R
authors.lastname: Deibel
authors.forename: R
authors.initials: R
authors.lastname: Gallo
authors.forename: R W
authors.initials: RW
authors.lastname: Stevens
authors.forename: N
authors.initials: N
authors.lastname: Ionascu
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009518:New York; D012283:Rickettsia prowazekii / Q000276:immunology; D012284:Rickettsia rickettsii / Q000276:immunology; D012286:Rickettsia typhi / Q000276:immunology; D014438:Typhus, Epidemic Louse-Borne / Q000175:diagnosis*
chemical_list: D000907:Antibodies, Bacterial