Inhibition of tissue prostaglandin synthesis during third molar surgery: use of preoperative fenbufen.
Preoperative administration of a non-steroidal anti-inflammatory drug (fenbufen) reduced immediate postoperative pain in a group of 38 patients undergoing removal of mandibular third molars, compared to placebo. However, overall pain experience and morbidity were not significantly improved suggesting that there was no clinical benefit derived from interference with tissue prostaglandin synthesis at the time of surgery.
Smith
A C
AC
Department of Oral and Maxillofacial Surgery, Nottingham General Hospital.
Brook
I M
IM
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000517:prevention & control*; D010654:Phenylbutyrates / Q000627:therapeutic use*; D010919:Placebos; D011292:Premedication; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D010654:Phenylbutyrates; D010919:Placebos; D011448:Prostaglandin Antagonists; C010725:fenbufen