title: Medical treatment of acute spinal cord injuries.
abstract: The injury was performed with 600 g-cm/weight on the spinal cord of 40 cats with T8-9 laminectomy in this study. Ten cats were given 10 mg/kg naloxone i.v. 1 h after injury. Ten cats were given 2 mg/kg thyrotropin-releasing hormone (TRH) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. Intravenous lidocaine was begun 30 min after injury in ten cats, administered as 1.5 mg/kg over the initial 5 min, 3 mg/kg over the next 30 min and 1 mg/kg every 30 min for 4 h. The remaining ten cats were given only saline (control group). TRH-treated cats showed significantly better histopathological scores than either naloxone- or lidocaine-treated animals (KW:13.65, P less than 0.50).
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Trabzon, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ceylan
authors.forename: M
authors.initials: M
authors.lastname: Kalelioğlu
authors.forename: G
authors.initials: G
authors.lastname: Aktürk
authors.forename: F
authors.initials: F
authors.lastname: Aktürk
authors.forename: S
authors.initials: S
authors.lastname: Ceylan
mesh_terms: D000208:Acute Disease; D000818:Animals; D002415:Cats; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone; D008012:Lidocaine