The disposition of tert-butyl-D-serine in the rat.
1. Following intravenous administration of 14C-tert-butyl-D-serine to rats, radioactivity was eliminated rapidly via the kidneys. 2. One metabolite was detected in urine and was identified as the N-acetyl derivative of tert-butyl-serine. 3. Elimination was more rapid in female than male rats.
Knott
S
S
Drug Metabolism Section, ICI Pharmaceuticals, Macclesfield, UK.
Warrander
A
A
Phillips
P J
PJ
Harding
J R
JR
D000818:Animals; D002247:Carbon Isotopes; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D015262:Xenobiotics
D002247:Carbon Isotopes; D015262:Xenobiotics; C063265:tert-butylserine; D012694:Serine