Infections after auxiliary partial liver transplantation. Experiences in the first ten patients.
In ten auxiliary partial liver transplant recipients selective bowel decontamination (SBD) was used to reduce infections due to gram-negative microorganisms and fungi. During SBD no gram-negative infections occurred. Candida peritonitis was observed in one patient. After discontinuation of SBD serious infections of gram-negative origin did occur and three fungal infections were seen. SBD seems to have a favourable effect in reducing infections by gram-negative microorganisms and fungi. Most striking was the number of enterococcal infections that occurred. Five out of ten patients developed enterococcal infections which in two cases contributed to a fatal outcome. These infections occurred after increase of the number of enterococci in faeces and concomitant positive cultures of bile, ascites or wound drains. This increase could be due to the use of SBD. Also, the kind of biliary anastomosis may play an important role in the relatively high incidence of enterococcal infections. In the postoperative period, recurrence of hepatitis B infection in the liver graft was observed in all patients with cirrhosis due to this virus. Problems caused by other viral infections or protozoal infections remained limited in these ten patients.
van Zeijl
J H
JH
Department of Clinical Microbiology, University Hospital, Rotterdam, The Netherlands.
Kroes
A C
AC
Metselaar
H J
HJ
Willemse
P J
PJ
Bruining
H A
HA
Sluiters
J F
JF
Schalm
S W
SW
Terpstra
O T
OT
Michel
M F
MF
D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000209:etiology*; D001662:Biliary Tract Surgical Procedures; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006509:Hepatitis B / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011292:Premedication / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents