Screening for potential in vivo phototoxicity in the lens/retina.
The eye is particularly vulnerable to damage from the phototoxic side effects of drugs since it is constantly subjected to ambient light. Presented here are several screens that can be used to determine the potential of drugs to cause light damage to the eye. These include a simple screen that takes into account the optical properties of the eye and the absorption spectra of the various drugs. This can be used to omit various drugs as potential photooxidants in the eye. In addition a second, more detailed screen is presented. This can be used to determine a) the quantitative potential for a drug to cause photooxidative damage in the eye, b) the mechanism by which it occurs and c) the in vivo verification of phototoxicity.
Roberts
J E
JE
Division of Science and Mathematics, Fordham University, New York City, NY 10023.
Dillon
J
J
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects / Q000528:radiation effects*; D008027:Light / Q000009:adverse effects*; D009883:Ophthalmic Solutions / Q000633:toxicity*; D010787:Photosensitivity Disorders / Q000175:diagnosis*; D012160:Retina / Q000187:drug effects / Q000528:radiation effects*; D013050:Spectrometry, Fluorescence; D013057:Spectrum Analysis
D009883:Ophthalmic Solutions