Enhanced intestinal permeability to 51Cr-labeled EDTA in dogs with small intestinal disease.
Intestinal permeability in dogs with small intestinal disease was measured by quantitation of 24-hour urinary excretion of 51Cr-labeled EDTA following intragastric administration. Permeability was high in dogs with a variety of naturally acquired small intestinal diseases including wheat-sensitive enteropathy of Irish Setters, small intestinal bacterial over-growth, and giardiasis, and permeability was decreased after successful treatment. These findings indicate that the assessment of intestinal permeability may be a useful technique for detecting small intestinal disease and for monitoring the efficacy of treatment in dogs.
Hall
E J
EJ
Department of Veterinary Pathology, University of Liverpool, UK.
Batt
R M
RM
D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism / Q000662:veterinary; D002446:Celiac Disease / Q000378:metabolism / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D004492:Edetic Acid / Q000378:metabolism*; D005260:Female; D005873:Giardiasis / Q000378:metabolism / Q000662:veterinary; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000378:metabolism / Q000662:veterinary*; D007411:Intestinal Diseases, Parasitic / Q000378:metabolism / Q000662:veterinary; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010539:Permeability
D004492:Edetic Acid