title: Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates.
abstract: New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: M
authors.initials: M
authors.lastname: Rambaldi
authors.forename: A
authors.initials: A
authors.lastname: Locatelli
authors.forename: F
authors.initials: F
authors.lastname: Andreani
authors.forename: P
authors.initials: P
authors.lastname: Aresca
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles