title: Short chain diol metabolism in human disease states.
abstract: Recent clinical studies have shown the presence of two short chain diols, meso-2,3-butanediol and D/L-2,3-butanediol, and in most cases 1,2-propanediol in either serum or urine collected from humans in several apparently unrelated disease states: congenital propionic and methylmalonic acidemia, premature infants, and alcoholics both in the presence and absence of ethanol. In addition 1,2-propanediol has been shown in patients during prolonged starvation, and in patients with diabetic keto-acidosis. No common defect is known to exist in these metabolic states. Understanding how these compounds are produced in clinically well-defined diseases such as methyl malonic and propionic aciduria, however, may help explain how and why these compounds are produced in alcoholics.
authors.affiliation: Laboratory of Metabolism and Molecular Biology, National Institute on Alcoholism and Alcohol Abuse, Rockville, MD 20852.
authors.forename: J P
authors.initials: JP
authors.lastname: Casazza
authors.forename: B J
authors.initials: BJ
authors.lastname: Song
authors.forename: R L
authors.initials: RL
authors.lastname: Veech
mesh_terms: D000093:Acetoin / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism; D002072:Butylene Glycols / Q000378:metabolism*; D016883:Diabetic Ketoacidosis / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008661:Metabolism, Inborn Errors / Q000378:metabolism; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000378:metabolism*
chemical_list: D002072:Butylene Glycols; D011409:Propylene Glycols; C026978:2,3-butylene glycol; D019946:Propylene Glycol; D000093:Acetoin