[Advantages of topical therapy with polydeoxyribonucleotide in reparative processes after cauterization: experience at a center for early diagnosis of genital neoplasms].
This paper evaluates the common practice of a topic medical treatment following cautery (or other kinds of microsurgery) of the uterine cervix. Firstly, a controlled clinical trial on 116 patients treated with kanamycin sulphate alternated to polydeoxyribonucleotide vaginal suppositories, and 124 controls has been conducted. Subjective parameters (leukorrhea, bloody discharge, odorous discharge, more than three weeks vaginal discharge, itching, pain, burning) and colposcopy (Schiller test reactivity, squamo-columnar junction location, abnormal transformation zones, vascular striae, deepithelialized areas or frail epithelium) appeared more favorable in the treated group, the colposcopic finding of phlogosis being the only unfavorable finding more frequent among the treated patients. Successively, a controlled double blind clinical trial with kanamycin sulphate alternated to placebo vs PDRN at different dosages has shown an increase in number of epithelial cells in the treated patients and a better stimulation of fibroblasts by higher dosages of active substance. These results show the efficacy of the studied post cautery treatment schedule, and of PDRN in particular.
Minorchio
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E
Cattedra di Patologia Ostetrica e Ginecologica, Università degli Studi di Milano.
Bianco
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V
Corso
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F
D000287:Administration, Topical; D002425:Cautery; D002584:Cervix Uteri / Q000473:pathology; D003127:Colposcopy; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007612:Kanamycin / Q000627:therapeutic use; D011089:Polydeoxyribonucleotides / Q000008:administration & dosage*; D002577:Uterine Cervical Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D011089:Polydeoxyribonucleotides; D007612:Kanamycin
Vantaggi della terapia topica con polidesossiribonucleotide sui processi riparativi post DTC: esperienza di un centro di diagnosi precoce delle neoplasie genitali.