[Incidence of antigen expression for HLA antigens A,B,C and DR in patients with atopic diseases in Poland].
Studies of several authors suggest an interdependence of atopic diseases and HLA antigens. Therefore, the authors evaluated an incidence of HLA antigens of classes I and II in patients with atopic disease and healthy individuals. The study involved 127 patients with atopy and 79 healthy blood donors. Anamnesis, results of skin tests and serum levels of allergenic-specific IgE served as the base of atopy diagnosis or exclusion. HLA antigens were assayed with a standard micro-lymphocytotoxic test using two series of standard anti-HLA sera. It enabled to detect 16 locus A-dependent antigens, 25 locus B-dependent and 8 locus C-dependent antigens as well as 8 antigens dependent on locus DR. Only antigen HLA-Bw53 was found more frequently in patients with atopic diseases suggesting its relation to atopy. The results concerning other HLA antigens did not confirm HLA antigens association with atopy suggested by other authors.
Kruszewski
J
J
III Kliniki Instytutu Medycyny Wewnetrznej, Warszawie.
Kłos
M
M
Nowak
J
J
Wasek
Z
Z
D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000276:immunology*; D012882:Skin Tests
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens
Czestość wystepowania antygenów HLA A, B, C i DR u chorych z chorobami atopowymi w Polsce.