Activity of DMBA, DMH and CP in triple- and single-dose rodent bone-marrow micronucleus assays.
1,2-Dimethylhydrazine, 7,12-dimethylbenzanthracene and cyclophosphamide were detected as positive using the triple-dose test protocol described by MacGregor (1989). Determination of the 3 day MLD may complicate the use of this test protocol.
Tinwell
H
H
ICI Central Toxicology Laboratory, Macclesfield, Cheshire, Great Britain.
Bandara
L
L
Ashby
J
J
D019813:1,2-Dimethylhydrazine; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000008:administration & dosage / Q000494:pharmacology*; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests / Q000379:methods; D009153:Mutagens / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D009153:Mutagens; D015127:9,10-Dimethyl-1,2-benzanthracene; D003520:Cyclophosphamide; D019813:1,2-Dimethylhydrazine