title: Influence of photoperiod and 6-methoxybenzoxazolinone on the reproductive axis of inbred LSH/Ss Lak male hamsters.
abstract: Adult male Syrian hamsters of the inbred LSH/Ss Lak strain were maintained under a 14L:10D light cycle until 13 weeks of age. At this point, they were implanted s.c. with elastomer capsules that were either empty or packed with 30-40 mg of 6-methoxybenzoxazolinone (6-MBOA), a compound found naturally in some monocotyledonous plants; half of the animals from each treatment group were then kept in long days (14L:10D) or transferred to short days (9L:15D). Testicular size was measured and blood samples collected from each hamster immediately before capsule implantation and again 2, 4, 6 and 8 weeks later. Within just 2 weeks of exposure to short days the mean plasma levels of LH and FSH had significantly declined, in both the control and 6-MBOA-treated animals, and were basal within 4 weeks. Testicular size closely followed these gonadotrophin changes; within 4-6 weeks the testes from all of the short-day hamsters had completely regressed to a prepubertal size. At the end of the experiment, at Week 8, the animals were killed and various components of the hypothalamo-pituitary-testicular axis were compared between the treatment groups. The pituitary content of FSH and LH, testicular weight, mean serum level of testosterone, but not hypothalamic LHRH content or pituitary gland weight, were considerably lower in the short-day than in the long-day hamsters, regardless of whether or not they had been chronically treated with 6-MBOA.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006.
authors.forename: H F
authors.initials: HF
authors.lastname: Urbanski
authors.forename: S O
authors.initials: SO
authors.lastname: Kim
authors.forename: M L
authors.initials: ML
authors.lastname: Connolly
mesh_terms: D000818:Animals; D001583:Benzoxazoles / Q000494:pharmacology*; D006224:Cricetinae; D005640:Follicle Stimulating Hormone / Q000032:analysis / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis / Q000276:immunology; D007106:Immune Sera; D008027:Light; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000737:chemistry; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D001583:Benzoxazoles; D007106:Immune Sera; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C031896:6-methoxybenzoxazolinone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone