[Oral contraceptive and hepatic effects].
The general use of synthetic estrogens like DC pointed out that near many skilled collateral effects, some others that are showing with a decrease of bile excretion (cholestasis), reversible with their administration interruption; with hepatic cells adenoma that are potentially premalignant and can transform into hepatocellular carcinoma; with vascular complications such as (most frequently in carcinomatousis) "hepatic peliosis" and "thrombosis" of suprahepatic veins (Budd-Chiari's syndrome). There is no overall increase in the incidence of gallbladder disease (cholelithiasis and cholecystitis).
Tarantino
G
G
Istituto di Medicina Interna e Malattie Dismetaboliche, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.
Morelli
L
L
Califano
C
C
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced / Q000503:physiopathology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced
D003278:Contraceptives, Oral, Hormonal
Contraccettivi orali e danno epatico.