De novo astrocytoma following immunosuppression in neurofibromatosis.
A 45-year-old man with a 20-year history of neurofibromatosis (NF-1) developed a massive astrocytoma 15 months following heart transplantation. CT before immunosuppressive therapy was normal. This is the 1st report of a de novo astrocytoma following immunosuppression in NF-1 and may indicate a causal relationship.
Wijdicks
E F
EF
University Department of Neurology, Utrecht, The Netherlands.
Jambroes
G
G
Riccardi
V M
VM
D001254:Astrocytoma / Q000209:etiology*; D001932:Brain Neoplasms / Q000209:etiology*; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology*; D014057:Tomography, X-Ray Computed