title: Femoral strain adaptation after total hip replacement: a comparison of cemented and porous ingrowth components in canines.
abstract: The purpose of this study was to investigate if experimental strain analysis is predictive of femoral adaptation after total hip replacement (THR). Ten large adult dogs underwent unilateral THR with identical implants. Five implants were press fit for porous ingrowth fixation, and five were cemented. Four months after surgery femora were harvested. Strain gauge rosettes were applied to the femora at eight proximal locations. Femora were compressively loaded on the head of the femur or femoral component. Strain data represented three conditions: preoperative, acutely postoperative, and four-month postoperative. The unoperated femur of each dog was used to simulate preoperative and acutely postoperative behavior of the contralateral implanted femur. Strains from each condition were compared. Transverse femoral sections were obtained through the levels of the strain gauges. Fine detailed radiographs were used to quantify morphological changes. Results showed cemented and uncemented implantations produce similar trends but different amounts of bone adaptation. Adaptations were generally consistent in direction with strain perturbations caused by implantation, but the extent of adaptation did not strongly correlate with the magnitude of perturbations. Also, there was no consistent trend towards normalization of altered strains. Results suggest that strain perturbations after THR may be mechanical triggers for morphological changes, but caution is required when predicting the extent of these changes or the autoregulatory role of strain.
authors.affiliation: Division of Orthopaedic Surgery, School of Veterinary Medicine, University of Wisconsin, Madison.
authors.forename: R
authors.initials: R
authors.lastname: Vanderby
authors.forename: P A
authors.initials: PA
authors.lastname: Manley
authors.forename: D M
authors.initials: DM
authors.lastname: Belloli
authors.forename: S S
authors.initials: SS
authors.lastname: Kohles
authors.forename: R J
authors.initials: RJ
authors.lastname: Thielke
authors.forename: A A
authors.initials: AA
authors.lastname: McBeath
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006622:Hip Prosthesis; D011859:Radiography; D013314:Stress, Mechanical
chemical_list: D001843:Bone Cements