[The usefulness of HIV serology in the follow up of vertical transmission of AIDS].
We study 37 children with mothers infected by human immunodeficiency virus type 1 (HIV-1) at birth and over the following three years. HIV-1 serology of these patients is reported, i.e., HIV-1 antigen p24 and antibodies using two commercially available enzymatic methods and Western blot. Throughout follow-up, IgG antibodies to HIV-1 showed a statistically significant tendency to decrease (p less than 0.001). After 12 months, 70% of the children lacked HIV-1 antibody banding by Western blot; this was taken to constitute a definitive criterion of lack of antibodies to HIV-1. Five children presented p24 antigenemia during the study, four persistently so. Of the patients over 18 months of age, 8 presented HIV-1 infection symptoms (30.7%), and three suffered AIDS (11.5%).
Tuset Ruiz
C
C
Sección de Inmunología del Servicio de Hematologia, Hospital General y Universitario de Valencia.
León Sebastia
P
P
Elorza Arizmendi
J
J
Tuset Ruiz
L
L
Vidal Rico
S
S
Tacons Mateu
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission*; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000276:immunology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D015483:HIV Antibodies
Utilidad de la serología del virus de la inmunodeficiencia humana tipo 1 en el seguimiento de la transmisión vertical del SIDA.