title: Disseminated intravascular coagulation and myocardial infarction in a haemophilia B patient during therapy with prothrombin complex concentrates.
abstract: A case of disseminated intravascular coagulation (DIC) and fatal myocardial infarction in a haemophilia B patient is described. DIC occurred after 4 days of therapy with unactivated prothrombin complex concentrates during the post-operative period. Therapy with fresh frozen plasma, heparin and antithrombin III concentrates was started without efficacy; after autopsy myocardial infarction was evident.
authors.affiliation: Department of Human Biopathology, University La Sapienza, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Chistolini
authors.forename: M G
authors.initials: MG
authors.lastname: Mazzucconi
authors.forename: M C
authors.initials: MC
authors.lastname: Tirindelli
authors.forename: G
authors.initials: G
authors.lastname: La Verde
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D001779:Blood Coagulation Factors / Q000009:adverse effects* / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D002836:Hemophilia B / Q000150:complications / Q000188:drug therapy*; D006552:Hernia, Inguinal / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D011300:Preoperative Care
chemical_list: D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates