Effects of organophosphates on bioelectrical activity of the brain.
Effects on electroencephalogram of acute and chronic exposure of two main groups of organophosphates: classic anticholinesterases (OP) and new bicyclic organophosphates (PTBO) are described. The role of muscarinic receptors of the midbrain reticular formation in the mechanism of action of OP and the possible mechanism of action of PTBO as blockers of a chloride ionophore of the GABA receptor complex are presented. The mechanism of convulsive activity of both groups are also discussed.
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Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warszawa, Poland.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects*; D007531:Isoflurophate / Q000494:pharmacology; D008464:Mecamylamine / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology; D011220:Pralidoxime Compounds / Q000494:pharmacology; D011817:Rabbits
D001643:Bridged Bicyclo Compounds; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D011220:Pralidoxime Compounds; D007531:Isoflurophate; D008464:Mecamylamine; D001285:Atropine; D003975:Diazepam