Ventricular histamine concentrations and mast cell counts in the rat heart during acute ischaemia.
The ventricular histamine concentrations and mast cell counts of naive and disodium cromoglycate-treated rats subjected to acute left coronary artery ligation under pentobarbitone anaesthesia were examined. In naive animals, there was a significant increase in the right ventricular histamine level at 2 min following left coronary artery ligation. Left ventricular histamine concentrations tended to decrease, and were significantly lower than those of the right ventricle at 5 min. However there were no significant changes in mast cell counts of the right or left ventricles after left coronary artery ligation. Treatment with disodium cromoglycate did not significantly alter the ventricular mast cell counts, interfere with the changes in ventricular histamine concentrations, or the occurrence of early ventricular arrhythmias and haemodynamic changes in response to acute left coronary artery ligation. It is suggested that the increase in the right and decrease in the left ventricular histamine concentrations during acute myocardial ischaemia involves mainly the non-mast cell stores, instead of mast cell sources, of cardiac histamine.
Dai
S
S
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Ogle
C W
CW
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002452:Cell Count; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D003331:Coronary Vessels; D004205:Cromolyn Sodium / Q000494:pharmacology; D006352:Heart Ventricles / Q000166:cytology / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006632:Histamine / Q000378:metabolism*; D008026:Ligation; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D006632:Histamine; D004205:Cromolyn Sodium