Accumulation and distribution of aliphatic (n-nonane), aromatic (1,2,4-trimethylbenzene) and naphthenic (1,2,4-trimethylcyclohexane) hydrocarbons in the rat after repeated inhalation.
The concentrations of the C9 hydrocarbons n-nonane, 1,2,4-trimethylbenzene and 1,2,4-trimethylcyclohexane were measured in rat blood, brain and perirenal fat after exposures to 1000 p.p.m. of the individual compounds. Measurements were made by head space gas chromatography at the end of 12 hr exposures on days 1, 3, 7, 10 and 14 of the exposure periods. The relative concentrations of hydrocarbons in each organ were, brain: n-nonane "trimethylcyclohexane approximately trimethylbenzene, blood: trimethylbenzene "n-C9 greater than trimethylcyclohexane and perirenal fat: trimethylbenzene greater than n-nonane greater than trimethylcyclohexane, showing the widely different distribution properties of the different hydrocarbons. Brain/blood ratios of 11.4, 2.0 and 11.4, and fat/blood ratios of 113, 63 and 135 were found for n-nonane, trimethylbenzene and trimethylcyclohexane, respectively. A marked decrease in biological concentrations of trimethylbenzene and trimethylcyclohexane during the initial phase of exposure indicate that these hydrocarbons are capable of inducing their own metabolic conversion resulting in lower steady state levels. A special attention was made to n-nonane showing the highest concentration in brain concomitantly with a low blood concentration. This observation demonstrate that biological monitoring of occupational exposure by blood measurements not should be performed without knowledge of the distribution properties of the compounds investigated.
Zahlsen
K
K
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Trondheim, Norway.
Nilsen
A M
AM
Eide
I
I
Nilsen
O G
OG
D000042:Absorption; D000280:Administration, Inhalation; D000473:Alkanes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001555:Benzene Derivatives / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003510:Cyclohexanes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006838:Hydrocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000473:Alkanes; D001555:Benzene Derivatives; D003510:Cyclohexanes; D006838:Hydrocarbons; C069243:1,2,4-trimethylcyclohexane; C010313:pseudocumene; C017573:nonane