Thyroidectomy reduces stress-induced prolactin secretion in rats. Participation of brain serotonergic systems.
Plasma prolactin levels were measured in thyroidectomized and sham-operated rats under immobilization stress. Thyroidectomy significantly reduced prolactin secretion during stress. The pretreatment of thyroidectomized rats with 6-chloro-2-[1-piperazinyl]- pyrazine (MK 212), a serotonin agonist that easily penetrates the blood-brain barrier, reversed the reduction in stress-induced prolactin release in the thyroidectomized group.
Ramalho
M J
MJ
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.
Reis
L C
LC
Nonaka
K
K
Antunes-Rodrigues
J
J
de-Castro-e-Silva
E
E
D000818:Animals; D001923:Brain Chemistry; D008297:Male; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis*; D013312:Stress, Physiological / Q000097:blood*; D013965:Thyroidectomy
D011719:Pyrazines; D011985:Receptors, Serotonin; C014896:6-chloro-2-(1-piperazinyl)pyrazine; D011388:Prolactin