title: The experimental use of cocaine in human subjects.
abstract: Continuation of the practice of experimental administration of cocaine to cocaine-addicted volunteers has been recommended by some investigators. The author's view is that the risk of experimental use of cocaine outweighs its benefits and that this practice should not be pursued. The author describes the damaging effects of cocaine on the cardiovascular system, particularly its ability to induce myocardial band necrosis, and the unique reinforcing properties of the drug. The legal and ethical issues raised by the experimental use of cocaine are also discussed.
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: G G
authors.initials: GG
authors.lastname: Nahas
mesh_terms: D003042:Cocaine / Q000009:adverse effects*; D004992:Ethics, Medical; D006805:Human Experimentation; D006801:Humans; D035842:Research Subjects; D035844:Researcher-Subject Relations; D018570:Risk Assessment; D019966:Substance-Related Disorders
chemical_list: D003042:Cocaine