Reactivity toward cysteine of antimicrobial carbamimidothioic acid phenylalkylesters salts.
The rates of reaction toward cysteine of a series of carbamimidothioic acid phenylmethylesters halides were investigated in phosphate buffer pH 7.4 at 37 degrees C under pseudo-first-order conditions. The reaction involves nucleophilic attack of cysteine on the C-S bond of isothiouronium mojety and corresponding benzenemethanethiols were detected as product of the reaction. Apparent first-order rate constants were determined.
Tait
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A
Dipartimento di Scienze Farmaceutiche, University of Modena, Italy.
Di Bella
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M
D000890:Anti-Infective Agents / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry* / Q000494:pharmacology
D000890:Anti-Infective Agents; D013859:Thiocarbamates; D003545:Cysteine