Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei.
Seselidiol [1], a new polyacetylene, has been isolated from the roots of Seseli mairei. On the basis of chemical and spectroscopic evidence, its structure has been established as heptadeca-1,8(Z)-diene-4,6-diyne-3,10-diol. Seselidiol and its acetate have been demonstrated to show moderate cytotoxicity against KB, P-388, and L-1210 tumor cells.
Hu
C Q
CQ
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Chang
J J
JJ
Lee
K H
KH
D000114:Acetylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D001704:Biopolymers; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D053281:Enediynes; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D015394:Molecular Structure; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D001704:Biopolymers; D004365:Drugs, Chinese Herbal; D053281:Enediynes; D011108:Polymers; C066691:seselidiol; D000114:Acetylene