Time-resolved laser-induced fluorescence spectroscopy for enhanced demarcation of human atherosclerotic plaques.
We report on the enhanced demarcation between human atherosclerotic plaques and normal vessel wall obtained using time-resolved detection of laser-induced fluorescence rather than the customary time-integrated monitoring technique. A frequency-doubled mode-locked and cavity-dumped continuous wave dye laser was used for picosecond pulse generation at 320 nm, and photon-counting techniques were employed for the time-resolved signal monitoring from human aorta samples in vitro. Implications for imaging fluorescence angioscopy and spectroscopic guidance in laser ablation of plaque are indicated.
Andersson-Engels
S
S
Department of Physics, Lund Institute of Technology, Sweden.
Johansson
J
J
Stenram
U
U
Svanberg
K
K
Svanberg
S
S
D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007834:Lasers; D013050:Spectrometry, Fluorescence / Q000379:methods*