Effect of sera from acute lymphoblastic leukemia children on proliferation and differentiation of HL-60 promyelocytic leukemia cell line.
Influence of sera of children with ALL on character (dispersed or compact) and composition (granulocyte or macrophage) of colonies, formed from the human promyelocytic leukemia cell line HL-60, was estimated. An increased activities stimulating formation of dispersed G and M colonies was found in the sera of patients before therapy. Dynamics of colonies formation and their composition in the course of treatment point to some changes in the serum the levels of these activities with a tendency to full normalization in remission.
Swiderska
J
J
Department of Biochemical Diagnostics, Institute of Laboratory Diagnostics, Medical School, Białystok.
Szmitkowski
M
M
Kondracka
E
E
D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002648:Child; D006098:Granulocytes / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D014407:Tumor Cells, Cultured / Q000473:pathology