[Effects of At-211 alpha irradiation on Ehrlich ascites tumor cells].
The biological effect of 211At alpha-particles has been investigated using the Chinese hamster fibroblasts and Ehrlich carcinoma cells growth in vitro. The mean energy of 211At alpha-particles is 6.8 MeV, LET in tissue is 70-160 keV/microns; the half-life period of decomposition of 211At is 7.2 h. The end-points used were a decrease in the mitotic activity, an elevation of the number of degenerating cells, cell with chromosome aberrations and the cell survival. The RBE of alpha-particles in comparison with 60Co gamma-rays is close to 3.
Shmakova
N L
NL
Norseev
Iu V
IuV
Waĭnson
A A
AA
Siuch
Z
Z
Fadeeva
T A
TA
Fomenkova
T E
TE
Khalkin
V A
VA
Cherebatenko
A P
AP
D000512:Alpha Particles; D000818:Animals; D001246:Astatine / Q000378:metabolism / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy*; D006224:Cricetinae; D003412:Cricetulus; D004735:Energy Transfer; D005347:Fibroblasts / Q000528:radiation effects; D006207:Half-Life; D008954:Models, Biological; D011882:Radiotherapy, High-Energy; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D001246:Astatine
Deĭstvie alfa-izlucheniia 211-At na kletki astsitnogo raka Erlikha.