title: Coproduction of surfactin and iturin A, lipopeptides with surfactant and antifungal properties, by Bacillus subtilis.
abstract: Of the 13 strains of Bacillus subtilis tested for the coproduction of the lipopeptide surfactin and the antifungal lipopeptides of the iturin family, only 1 produced both lipopeptides with a high yield. The cultures were made in a synthetic medium. Several L-amino acids and various carbon sources were good substrates for the lipopeptide production. The maximum yield of surfactin was about 110 mg/liter and that of iturin A about 39 mg/liter/absorbance unit for the best strain, B. subtilis S 499.
authors.affiliation: Laboratoire de Biochimie Microbienne, Université Claude Bernard, Lyon I, France.
authors.forename: C
authors.initials: C
authors.lastname: Sandrin
authors.forename: F
authors.initials: F
authors.lastname: Peypoux
authors.forename: G
authors.initials: G
authors.lastname: Michel
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000378:metabolism; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D002855:Chromatography, Thin Layer; D055666:Lipopeptides; D008074:Lipoproteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013501:Surface-Active Agents / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001426:Bacterial Proteins; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C009365:surfactin peptide; C013579:iturin A