Possible lymphocyte effects on lactase expression by mouse jejunal enterocytes.
Jejunal intraepithelial lymphocyte numbers fall and lactase activity increases during early infection with the intestinal parasite Nematospiroides dubius. Both these variables later return to values found in control mice. These results support the view that local immune reactions, suppressed by the presence of N. dubius, normally inhibit lactase expression by mouse enterocytes.
Savidge
T C
TC
Department of Cell Biology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
Smith
M W
MW
Kilshaw
P J
PJ
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D016827:CD8 Antigens; D005696:Galactosidases / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007583:Jejunum / Q000166:cytology / Q000201:enzymology* / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000201:enzymology / Q000276:immunology*; D009351:Nematospiroides dubius / Q000276:immunology; D001616:beta-Galactosidase / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D005696:Galactosidases; D001616:beta-Galactosidase