[Influence of local anesthetics and narcotics on the energy metabolism of Ehrlich ascites tumor cells].
The suitability of Ehrlich ascites tumour cells as a test object for potential drugs affecting ATP-producing or consuming processes directly or indirectly is made likely by actions of local anesthetics and narcotics on the energy metabolism of these cells. The influence of local anesthetics on cation transport and Ca+(+)-dependent processes as well as the inhibition of NADH-ubiquinone reductase by narcotics is demonstrated for Ehrlich ascites tumour cells, too.
Buttgereit
F
F
Institut für Biochemie, Bereich Medizin (Charite), Humboldt-Universität zu Berlin, DDR.
Müller
M
M
Rapoport
S M
SM
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D016660:NAD(P)H Dehydrogenase (Quinone); D009294:Narcotics / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D011808:Quinone Reductases / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
D000779:Anesthetics, Local; D009294:Narcotics; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D010100:Oxygen; D002118:Calcium
Einfluss von Lokalanästhetika und Narkotika auf den Energiestoffwechsel von Ehrlich-Ascites-Tumorzellen.