Respiratory and sedative effects of clobazam and clonazepam in volunteers.
1. The respiratory and psychomotor effects of two benzodiazepines used mainly as anticonvulsants were compared in healthy volunteers, using a double-blind placebo controlled design. 2. Clobazam (10 and 20 mg) produced significantly fewer psychomotor side effects than clonazepam (0.5 and 1 mg). Neither drug at either dose affected the ventilatory response to CO2. 3. Although clonazepam produced significant effects on psychomotor performance, these did not correlate with plasma drug concentration. 4. Our studies provide further evidence that at the doses chosen clobazam is considerably less sedating than clonazepam. Further investigation is required into the tolerance profile of both drugs in patients.
Wildin
J D
JD
Department of Physiological Sciences, University of Manchester.
Pleuvry
B J
BJ
Mawer
G E
GE
Onon
T
T
Millington
L
L
D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000494:pharmacology; D000078306:Clobazam; D002998:Clonazepam / Q000097:blood / Q000494:pharmacology*; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D011187:Posture; D011597:Psychomotor Performance / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D012016:Reference Values; D012119:Respiration / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D002245:Carbon Dioxide; D000078306:Clobazam; D002998:Clonazepam