title: The secretion of human growth hormone stimulated by human growth hormone releasing factor following severe cranio-cerebral trauma.
abstract: Patients suffering from severe cranio-cerebral trauma show alterations of the secretory patterns of thyroid stimulating hormone (TSH) and human growth hormone (HGH) which may be of prognostic significance. We studied 10 patients following severe brain injury and prospectively compared a new synthetic human growth hormone releasing factor (HGHRF) test with the thyrotropin releasing hormone (TRH) test. On admission, all patients had a Glasgow Coma Scale score of 3 or 4. All patients had a low T3 syndrome. In the patients who died the TSH response after stimulation with TRH was also absent. In the patients who survived a significant TSH increase was observed (p less than 0.05). In comparison to the patients who died those who survived showed a significant (p less than 0.001) HGH increase after HGHRF stimulation. This test might be useful as an additional tool in establishing early prognosis in patients with severe brain injury.
authors.affiliation: Department of Anesthesia, University Hospital of Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Gottardis
authors.forename: C
authors.initials: C
authors.lastname: Nigitsch
authors.forename: E
authors.initials: E
authors.lastname: Schmutzhard
authors.forename: M
authors.initials: M
authors.lastname: Neumann
authors.forename: C
authors.initials: C
authors.lastname: Putensen
authors.forename: J M
authors.initials: JM
authors.lastname: Hackl
authors.forename: W
authors.initials: W
authors.lastname: Koller
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D005260:Female; D015600:Glasgow Coma Scale; D013006:Growth Hormone / Q000096:biosynthesis / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013972:Thyrotropin / Q000096:biosynthesis / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D013974:Thyroxine