title: Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men.
abstract: OBJECTIVE
  To determine the prevalence, incidence, and persistence of positivity for antibodies to hepatitis C virus (anti-HCV) and the potential for sexual transmission of the virus.
  
  
  METHODS
  A cohort analysis covering 1981-9 comparing estimated cumulative incidences of and seroconversion rates for anti-HCV with those of hepatitis B core antibody (anti-HBc) and antibodies to the human immunodeficiency virus (anti-HIV).
  
  
  METHODS
  Copenhagen and Aarhus, Denmark.
  
  
  METHODS
  259 Male members of a Danish homosexual organisation.
  
  
  METHODS
  Correlations of prevalence and incidence with a wide range of sexual lifestyle variables.
  
  
  RESULTS
  Only four (1.6%) subjects were positive for anti-HCV in 1981. The estimated cumulative incidence of positivity for anti-HCV was 4.1% in 1984 (seroconversion rate during 1981-4 (2.5%)) and remained at 4.1% in 1989 (seroconversion rate nil during 1984-9). In contrast, positivity for anti-HBC rose from 44.0% in 1981 to 52.7% in 1984 (seroconversion rate 15.5%) and 58.8% in 1989 (seroconversion rate 12.9%), and that for anti-HIV rose from 8.8% to 24.0% (seroconversion rate 16.7%) and 30.1% (seroconversion rate 8.0%) respectively. Three anti-HCV positive patients seroreverted three to five years later. None of the anti-HCV positive subjects had had a transfusion and only one gave a past history of intravenous drug use. Variables in sexual lifestyle correlated with the presence of anti-HBc but not with that of anti-HCV.
  
  
  CONCLUSIONS
  In contrast with hepatitis B virus and HIV, sexual transmission of hepatitis C virus seems to be a rare event. Furthermore, antibodies to the virus may become undetectable after several years.
authors.affiliation: Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Melbye
authors.forename: R J
authors.initials: RJ
authors.lastname: Biggar
authors.forename: P
authors.initials: P
authors.lastname: Wantzin
authors.forename: K
authors.initials: K
authors.lastname: Krogsgaard
authors.forename: P
authors.initials: P
authors.lastname: Ebbesen
authors.forename: N G
authors.initials: NG
authors.lastname: Becker
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D006679:HIV Seropositivity / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis; D006510:Hepatitis B Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012747:Sexual Partners; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology / Q000276:immunology*; D013997:Time Factors
chemical_list: D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies