Third place--Resident Clinical Science Award 1990. The in vivo and in vitro effect of phenylephrine (Neo Synephrine) on nasal ciliary beat frequency and mucociliary transport.
Twenty volunteers with normal noses were studied to determine the effect of phenylephrine on nasal ciliary function. In vivo study of this drug was performed in 15 patients and revealed a significant increase in their ciliary beat frequency from a control of 11 Hz to 12.03 Hz (p = 0.001). Mucociliary transit times in these volunteers were also studied, revealing a mean of 9.9 minutes prestimulation and 10.2 minutes poststimulation, which was not statistically significant (p = 0.77). Five additional subjects donated ciliated mucosal samples for in vitro analysis of varying concentrations of this agent that showed a significant ciliostimulatory effect at lower concentrations (0.01%), with a progressive cilioinhibitory effect at higher concentrations (0.25%, 0.5%). The 0.05% concentration showed no significant change in ciliary activity compared to control measurements. These data demonstrate that phenylephrine has a ciliostimulatory effect in vivo, as well as in appropriate concentrations in vitro, and should be safe and relatively nontoxic to the mucociliary apparatus for short-term use.
Phillips
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PP
Department of Otolaryngology, Mayo Clinic-Rochester, MN 55901.
McCaffrey
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TV
Kern
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EB
D001363:Awards and Prizes; D002478:Cells, Cultured; D002923:Cilia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects*; D009666:Nose / Q000187:drug effects*; D010036:Otolaryngology; D010656:Phenylephrine / Q000494:pharmacology*; D012016:Reference Values; D014481:United States
D010656:Phenylephrine