Serum apolipoprotein A-I in alcoholic patients with chronic calcifying pancreatitis.
Serum apolipoprotein A-I measurement was compared in alcoholic patients according to presence or absence of chronic pancreatitis and liver fibrosis. Among alcoholic patients without liver disease, apolipoprotein A-I was significantly lower in patients with chronic pancreatitis (157 +/- 70 mg/dl) than in patients without pancreatitis (209 +/- 74 mg/dl, p less than 0.001). In cirrhotic patients, apolipoprotein A-I was lower in patients with chronic pancreatitis (82 +/- 35 mg/dl) than in patients without pancreatitis (102 +/- 45 mg/dl), but this difference was not significant. The decrease of serum apolipoprotein A-I was independent of nutritional parameters whether or not there was cirrhosis. Immunohistochemical study of pancreatic samples with chronic pancreatitis showed that apolipoprotein A-I was located in the pancreatic fibrosis whereas lobules were unstained. This study suggests that apolipoprotein A-I is trapped by the pancreatic extracellular matrix and that this sequestration might explain, in part, the decrease of the serum apolipoprotein A-I.
Poynard
T
T
Service d'Hepato-Gastroentérologie, Hôpital Antoine Béclère, Clamart, France.
Bedossa
P
P
Jais
P
P
Abella
A
A
Naveau
S
S
Aubert
A
A
Lemaigre
G
G
Chaput
J C
JC
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000150:complications*; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000032:analysis / Q000097:blood*; D002114:Calcinosis / Q000150:complications*; D002908:Chronic Disease; D005109:Extracellular Matrix / Q000737:chemistry; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000737:chemistry; D010195:Pancreatitis / Q000097:blood / Q000150:complications* / Q000378:metabolism; D012189:Retrospective Studies
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A