Nutmeg oil: identification and quantitation of its most active constituents as inhibitors of platelet aggregation.
Three distilled or commercially available nutmeg oils were analysed and their chemical composition compared with their capacity to inhibit platelet aggregation in vitro. It could be clearly shown that eugenol and isoeugenol play the major role in the detected activity of nutmeg. Medicinally, it appears that nutmeg oil and nutmeg powder can be replaced by eugenol and/or isoeugenol.
Janssens
J
J
Department of Pharmaceutical Sciences, University of Antwerp (UIA), Wilrijk, Belgium.
Laekeman
G M
GM
Pieters
L A
LA
Totte
J
J
Herman
A G
AG
Vlietinck
A J
AJ
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003212:Condiments / Q000032:analysis*; D005054:Eugenol / Q000031:analogs & derivatives / Q000032:analysis; D066298:In Vitro Techniques; D010938:Plant Oils / Q000032:analysis / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D011817:Rabbits
D001095:Arachidonic Acids; D010938:Plant Oils; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D005054:Eugenol; C036643:isoeugenol