title: Interleukin-2 inhibits growth of fibroblasts derived from human bone marrow.
abstract: The adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells (CFU-F). We have demonstrated that recombinant interleukin-2 (r-IL2) inhibits growth of CFU-F by preventing their entry into S phase. This inhibition is not mediated by gamma-interferon, nor by T lymphocytes, and can be abrogated by anti-IL2 receptor antibody. r-IL2 may influence haematopoiesis by its effect on bone marrow CFU-F.
authors.affiliation: Department of Haematology, Westminster Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: MacDonald
authors.forename: J A
authors.initials: JA
authors.lastname: Adams
authors.forename: D
authors.initials: D
authors.lastname: McCarthy
authors.forename: A J
authors.initials: AJ
authors.lastname: Barrett
mesh_terms: D001685:Biological Factors / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003114:Colony-Forming Units Assay; D016207:Cytokines; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D001685:Biological Factors; D016207:Cytokines; D007376:Interleukin-2; D011994:Recombinant Proteins