Is hepatitis C virus involved in hepatitis-associated aplastic anemia?
OBJECTIVE
To determine whether hepatitis C virus is involved in hepatitis-associated aplastic anemia.


METHODS
Retrospective analysis.


METHODS
Bone marrow transplantation unit.


METHODS
One hundred and eighteen patients with severe aplastic anemia, including 19 with hepatitis-associated aplasia, 61 with aplastic anemia of undetermined cause, and 38 with aplastic anemia related to an inherited syndrome or an acquired etiology.


RESULTS
There was no statistically significant difference in antihepatitis C virus antibodies between hepatitis-related aplastic anemia (15.8%; 95% CI, 4% to 36%) and aplasia of unknown (9.8%; CI, 5% to 22%) or known (7.9%; CI, 2% to 22%) cause. The antihepatitis C virus levels did not differ according to the cause of aplastic anemia. There was no relation between hepatitis C and hepatitis B virus serologies, regardless of cause.


CONCLUSIONS
Hepatitis C virus is not a frequent cause of non-A, non-B hepatitis-associated aplastic anemia. Either a non-A, non-B, non-C hepatitis virus is involved in non-A, non-B hepatitis-related aplasia or hepatitis C virus prevalence is underestimated in patients with hepatitis-related aplasia, possibly as a result of immunologic defects.
Pol
S
S
Hôpital Laënnec, Paris, France.
Driss
F
F
Devergie
A
A
Brechot
C
C
Berthelot
P
P
Gluckman
E
E
D000741:Anemia, Aplastic / Q000209:etiology*; D006508:Hepatitis Antibodies / Q000032:analysis; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D015995:Prevalence; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012698:Serologic Tests
D006508:Hepatitis Antibodies