Correlation of clinical and serological findings in patients with rheumatoid arthritis treated for one year with interferon-gamma.
Results of a large therapeutic trial of interferon-gamma in patients with rheumatoid arthritis (RA) are described. Of 110 RA-patients enrolled in this clinical trial, 46 were treated with interferon-gamma for 12 months. During the treatment period, dosage was reduced on an individual basis. There was a correlation between the improvement of clinical parameters, such as pain or morning stiffness, and the improvement of laboratory parameters such as erythrocyte sedimentation rate, anemia, leucocytosis or thrombocytosis. Interferon-gamma was well tolerated, and no organ toxicity was detected.
Sprekeler
R
R
Diakonissenkrankenhaus, Rotenburg, FRG.
Lemmel
E M
EM
Obert
H J
HJ
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000628:therapy*; D001772:Blood Cell Count / Q000187:drug effects; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011994:Recombinant Proteins; D012217:Rheumatoid Factor / Q000032:analysis
D000305:Adrenal Cortex Hormones; D011994:Recombinant Proteins; D007371:Interferon-gamma; D012217:Rheumatoid Factor