Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures.
1. Wistar rats of a strain presenting spontaneous petit mal-like seizures were injected intraperitoneally with graded doses of 14 non-monoamine oxidase inhibitor antidepressants and the immediate effects on behavior and the EEG were recorded. 2. Amineptine and nomifensine, the two drugs interacting with dopaminergic neurotransmission, reduced the duration of spontaneous spike-wave discharges (SWD) and were thus potentially antiepileptic. 3. Trazodone increased SWD duration. 4. The antidepressants, imipramine-like (imipramine, chlorimipramine, desipramine, metapramine and amitriptyline) and non-imipraminic (minaprine, maprotiline, viloxazine, mianserin, fluvoxamine and indalpine), and the 3 noted above, had potentially convulsive effects.
Warter
J M
JM
Clinique Neurologique, Hôpital Civil, Strasbourg, France.
Tranchant
C
C
Marescaux
C
C
Depaulis
A
A
Lannes
B
B
Vergnes
M
M
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013997:Time Factors
D000928:Antidepressive Agents