Long-range effects of direct-hit ultraviolet and particle radiation in oncogene activation.
A simple statistical analysis shows that the oncogene-activation effect of chemical carcinogens cannot be explained if one takes into account only short-range effects. As one of the most probable solid state physical long-range effects, the generation at the site of carcinogen binding of travelling solitary waves, which can interfere with DNA-blocking protein interactions, is discussed. It has been shown that the direct hit carcinogenic effects on DNA by ultraviolet--or particle radiation can also be explained by the generation of solitary waves (in the latter case the first step is a collective plasma oscillation which decays to individual local excitations and ionizations).
Ladik
J J
JJ
Laboratory of National Foundation for Cancer Research, Friedrich-Alexander-University Erlangen-Nürnberg, FRG.
D004247:DNA / Q000528:radiation effects; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects*; D009857:Oncogenes / Q000528:radiation effects*; D011827:Radiation; D013223:Statistics as Topic; D014466:Ultraviolet Rays
D004247:DNA