Enhanced in-vitro activity of liposome-trapped penicillin-G against Pseudomonas aeruginosa.
The growth inhibition of four Pseudomonas aeruginosa strains by liposome-trapped penicillin-G was investigated. There were indications of an association of the efficacy of liposomal penicillin-G with the nature of the 0-antigenic polymeric side chain. Namely, P28-800 and PCF-95 strains, characterized by a rough polysaccharide chain, were the most susceptible, whereas strain P28-0, possessing an intact lipopolysaccharide, resisted the activity of the entrapped drug. Among the rough strains, P642, a beta-lactamase producer, was not affected by the encapsulated drug. The composition of liposomes seems to have a significant impact in arresting the growth of the P. aeruginosa strain.
Kotsifaki
H
H
Department of Experimental Physiology, School of Health Sciences, Athens, Greece.
Tzouvelekis
L S
LS
Panagiotidou
G
G
Vatopoulos
A C
AC
Economopoulou
C
C
Legakis
N J
NJ
D002118:Calcium / Q000494:pharmacology; D004337:Drug Carriers; D008070:Lipopolysaccharides / Q000378:metabolism; D008081:Liposomes; D010400:Penicillin G / Q000008:administration & dosage* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D001618:beta-Lactamases / Q000378:metabolism
D004337:Drug Carriers; D008070:Lipopolysaccharides; D008081:Liposomes; C064821:beta-lactamase PSE-1; D001618:beta-Lactamases; D010400:Penicillin G; D002118:Calcium