Fluvoxamine in the treatment of menstrually related mood disorders.
Twenty women with premenstrual complaints were treated in a double-blind placebo controlled trial during two consecutive menstrual cycles with fluvoxamine, a selective serotonin uptake blocker. A beneficial effect was found on somatic and affective symptoms in both treatment groups, the effect of fluvoxamine being not different from placebo. The results of this study do not support a role for serotonin in menstrually related affective symptoms.
Veeninga
A T
AT
Department of General Psychiatry, Psychiatric Hospital Veldwijk, Ermelo, The Netherlands.
Westenberg
H G
HG
Weusten
J T
JT
D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine; D006801:Humans; D008183:Luteal Phase; D008598:Menstruation; D019964:Mood Disorders / Q000188:drug therapy* / Q000523:psychology; D010091:Oximes / Q000627:therapeutic use*
D000928:Antidepressive Agents; D010091:Oximes; D016666:Fluvoxamine