The effect of ofloxacin on the immune system of elderly patients.
In twenty elderly patients with infectious diseases, some immune parameters were evaluated before and after treatment with ofloxacin. Results showed that the number of T cells, B cells, gamma-Interferon plasma concentrations and serum immunoglobulin levels were not affected following ten days treatment (600 mg/per day). These data suggest that this antibiotic does not affect the immune parameters studied. However, inhibition of other immune functions cannot be excluded.
Munno
I
I
Cattedra di Immunologia, Università degli Studi Di Bari, Italy.
Arpinelli
F
F
Benedetti
M
M
Spoglianti
R
R
Ferlini
A
A
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007371:Interferon-gamma / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007371:Interferon-gamma; D015242:Ofloxacin