Living-unrelated renal transplantation at the University of Wisconsin.
1. Use of LUrDs under a DST protocol results in a 70% actuarial graft survival at 6 years which is not statistically different from haploidentical or primary cadaver recipients transplanted over the same time period. 2. Sensitization is common, despite the use of Aza, especially in husband-to-wife donor-to-recipient relationship. 3. Rejection occurs frequently, despite the use of DST, however, it is usually reversible. The high rejection rate did not influence the quality of long-term graft survival with very few patients losing grafts to chronic rejection. 4. Expansion of the use of LUrDs could help provide additional organs for transplantation.
Pirsch
J D
JD
Department of Medicine, University of Wisconsin School of Medical, Madison.
D'Alessandro
A M
AM
Sollinger
H W
HW
Voss
B J
BJ
Knechtle
S J
SJ
Reed
A
A
Kalayoglu
M
M
Belzer
F O
FO
D000328:Adult; D002102:Cadaver; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D012189:Retrospective Studies; D014019:Tissue Donors; D014922:Wisconsin