[Studies on antitumor drugs: the synthesis of N',N"-dispirotripiperaziniums].
In order to search for new antitumor drugs, sixteen N',N"-dispirotripiperazine derivatives were synthesized from N',N"-dispirotripiperazinium dichloride dihydrochloride by substitution, acylation and Mannich reaction. Six compounds were selected for preliminary pharmacological test. The result showed that five compounds possess inhibitory action against carcinoma S37 in rats. The inhibitory activity of compounds VI and X was 55.0% and 41.9% respectively.
Chen
H C
HC
Department of Chemistry, Zhengzhou University.
Liu
Z Z
ZZ
Li
R T
RT
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012511:Sarcoma 37 / Q000188:drug therapy; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D010879:Piperazines; D013141:Spiro Compounds; C069536:N,N''-dispirotripiperazine