[Comparison of chlorthalidone and sustained-action nifedipine in the treatment of mild to moderate arterial hypertension].
The effectiveness and safety of sustained action nifedipine (NF) were compared to those of chlorthalidone (CL) in two groups of 35 and 37 patients with mild to moderate hypertension followed up for 4 months. There was a significant reduction in blood pressure (BP) after 15 days of therapy. The degree of control was acceptable with both drugs. A second drug was required in 20% patients of the NF group and in 30.8% of CL group. The therapeutic goal (BP less than 160/95) was achieved in 86.7% of patients in CL group and in 48.4% of those in NF group. We found 48.8% of dropouts in the NF group and none in CL group. There was a significant increase in blood glucose in CL group and a reduction of uric acid and an increase of HDL-cholesterol in NF group. Both drugs are useful to treat hypertension, although NF has the drawback of a high dropout rate and CL induces abnormalities in biochemical parameters.
Martínez de la Iglesia
J
J
MF y C UD Córdoba.
de Diego Cabrera
M S
MS
González Santos
C
C
Iribarren Marín
M A
MA
Calderón de la Barca Gázquez
J M
JM
Pérula Torres
L
L
D000368:Aged; D002752:Chlorthalidone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D003692:Delayed-Action Preparations; D009543:Nifedipine; D002752:Chlorthalidone
Comparación de la clortalidona y nifedipina retardada en el tratamiento de la hipertensión arterial leve-moderada.