Synergistic action of clotrimazole and certain anionic surfactants may be due to ion pair formation.
A synergistic effect of clotrimazole and certain anionic surfactants against a strain of Candida albicans was confirmed. Measurement of apparent partition coefficients indicated that lipophilic ion pairs between clotrimazole and anionic surfactants were formed. It is suggested that the synergistic effect of the drugs may be due to ion pair formation.
Pedersen
M
M
Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark.
D002176:Candida albicans / Q000187:drug effects; D003022:Clotrimazole / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*
D013501:Surface-Active Agents; D003022:Clotrimazole