title: [Anti-angina effect of amiodarone versus delayed-action propranolol. A double-blind randomized study].
abstract: Long-acting Propranolol (160 mg/day) and Amiodarone (200 mg/day after impregnation) were compared in chronic stable angina pectoris. Forty-three patients with stable angina of effort were included in a randomised double blind trial (19 in the amiodarone and 24 in the propranolol group). The duration of the study was 8 weeks; the placebo phase (2 weeks) was followed by 6 weeks of active treatment. An exercise stress test was performed before and after the treatment period. The number of episodes of angina and the consumption of glyceryl trinitrate decreased significantly (p less than 0.001) in the same proportion with both drugs with respect to the placebo period. The time to the appearance of criteria of positivity of the exercise stress test increased from 6.82 +/- 0.50 mn to 8.35 +/- 0.50 mn with amiodarone, and from 7.15 +/- 0.47 mn to 9.50 +/- 0.52 with the propranolol preparation. This improvement was very significant compared with the placebo phase (p less than 0.001) but the difference between the two drugs was not statistically significant (p = 0.39). The other parameters which were studied (time to onset of angina, total duration of exercise, maximum heart rate, double product, maximum ST depression) changed in a parallel fashion significantly versus placebo. There were no differences between the two treatment groups with the exception of the resting heart rate which decreased more in patients on propranolol (80.94 +/- 3.92 to 62.47 +/- 1.97) than in patients on amiodarone (84.87 +/- 2.63 to 73.41 +/- 2.01; p less than 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service de cardiologie, hôpital Cochin, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Varin
authors.forename: C
authors.initials: C
authors.lastname: Pelissier
authors.forename: M
authors.initials: M
authors.lastname: Legendre
authors.forename: G
authors.initials: G
authors.lastname: Delorme
authors.forename: O
authors.initials: O
authors.lastname: Dubourg
authors.forename: P
authors.initials: P
authors.lastname: Weiss
authors.forename: J P
authors.initials: JP
authors.lastname: Bourdarias
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D011433:Propranolol; D000638:Amiodarone
vernacular_title: Effet anti-angineux de l'amiodarone. Etude randomisée en double aveugle contre le propranolol retard.