[Effects of prostaglandin E1 on cerebral blood flow, cerebrospinal fluid pressure, and spinal subarachnoidal compliance].
In enflurane-anesthetized subjects, controlled hypotension was induced by the intravenous administration of prostaglandin E1 (PGE1), and its effects on the cerebral blood flow (CBF) and intracranial pressure (ICP) were investigated by using changes in the flow velocity of the ophthalmic artery (OPA) and cerebrospinal fluid pressure (CSFP) as indices, respectively. After measurements of these hemodynamic variables, the spinal subarachnoidal compliance was also determined, and its relationship with the flow velocity in the ophthalmic artery and CSFP was investigated. The results of the study suggest that PGE1 causes no significant changes in CSFP and that cerebral blood flow is well-maintained despite a reduction in cerebral perfusion pressure.
Sugimoto
N
N
Department of Anesthesiology, School of Medicine, Jikei University, Tokyo.
Shudo
Y
Y
Takagi
Y
Y
D000527:Alprostadil / Q000494:pharmacology*; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003187:Compliance / Q000187:drug effects*; D006801:Humans; D013346:Subarachnoid Space / Q000187:drug effects*
D000527:Alprostadil