title: [2 year interferon therapy of metastatic carcinoid tumor].
abstract: A 39 year old male patient was treated with daily 5 X 10(6) IU interferon alpha 2b s.c. for 22 months because of advanced carcinoid tumor. Objective response was achieved with greater than 50% reduction of 5-HIAA-excretion. Multiple metastases (liver, lung, bones, thyroid gland) were not progressing in size. An unintentional omission of treatment resulted in a rapid biochemical and morphological tumor progression. Reversibility was achieved with reinstitution of effective interferon therapy. Thus, interferon therapy of advanced carcinoid tumor is able to induce a long-term objective response. It seems to be superior to conventional chemotherapy.
authors.affiliation: Medizinische Klinik I, Klinikum Grosshadern, Universität München.
authors.forename: W
authors.initials: W
authors.lastname: von Scheidt
authors.forename: M
authors.initials: M
authors.lastname: Böhm
authors.forename: I
authors.initials: I
authors.lastname: Huber
authors.forename: R
authors.initials: R
authors.lastname: Habersetzer
authors.forename: K
authors.initials: K
authors.lastname: Jacob
authors.forename: A
authors.initials: A
authors.lastname: Markl
authors.forename: G
authors.initials: G
authors.lastname: Autenrieth
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008134:Long-Term Care; D008175:Lung Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D009362:Neoplasm Metastasis; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
vernacular_title: Zweijährige Interferon-Therapie eines metastasierten Carcinoids.