Fibrinolytic responses to 1-desamino-8-D-arginine-vasopressin in patients with congenital nephrogenic diabetes insipidus.
Fibrinolytic responses to infusion of 1-desamino-8-D-arginine-vasopressin (DDAVP) were assessed in 6 males with congenital nephrogenic diabetes insipidus (NDI), 6 carriers of the NDI gene and 6 normal control subjects. Tissue-type plasminogen activator (t-PA) activity and antigen increased significantly in normal subjects, while plasminogen activator inhibitor (PAI) activity decreased. None of these changes were observed in patients with NDI. In 2 female carriers, normal fibrinolytic responses were seen, while in the other carriers responses were delayed. These findings are consistent with the concept of a general V2-receptor defect in congenital NDI. DDAVP tests are of limited use in NDI carrier detection.
Knoers
N
N
Department of Pediatrics, Catholic University Nijmegen, The Netherlands.
Brommer
E J
EJ
Willems
H
H
van Oost
B A
BA
Monnens
L A
LA
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D003919:Diabetes Insipidus / Q000097:blood / Q000151:congenital*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000151:congenital*; D008297:Male; D015849:Plasminogen Inactivators / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator; D003894:Deamino Arginine Vasopressin