Vitamin A sorption to polyvinyl and polyolefin intravenous tubing.
The loss of vitamin A to plastic infusion tubing from a total parenteral nutrition solution was studied using an in vitro infusion system and HPLC quantification of vitamin A. Polyolefin tubing was compared to polyvinyl chloride at varied vitamin A concentration, infusion temperature, and flow rate. Significantly enhanced recovery of vitamin A was found with the polyolefin tubing compared to that of the polyvinyl chloride under all conditions tested. After 24 hours under the varied conditions of the study, vitamin A availability ranged from 47 to 87% with polyolefin and 19 to 74% with polyvinyl chloride. These differences may be expected to result in significantly greater vitamin A delivery from polyolefin compared to polyvinyl chloride tubing to patients treated in neonatal intensive care units.
Henton
D H
DH
Division of Digestive Diseases and Nutrition, Childrens Hospital of Los Angeles, California.
Merritt
R J
RJ
D007262:Infusions, Intravenous / Q000009:adverse effects / Q000295:instrumentation*; D008422:Materials Testing; D010289:Parenteral Nutrition, Total / Q000009:adverse effects / Q000295:instrumentation*; D010969:Plastics; D011090:Polyenes; D011143:Polyvinyl Chloride; D013997:Time Factors; D014801:Vitamin A
D010969:Plastics; D011090:Polyenes; D014801:Vitamin A; C035051:PL 732; D011143:Polyvinyl Chloride