Histone H1 and the regulation of transcription of eukaryotic genes.
Histone H1 plays a role in the formation of chromatin structure, both at the level of the nucleosome particle itself and in the formation of the higher-order structures of the chromatin fibre. Histone H1 is regarded as a part of a general repressor mechanism that ensures a strong and stable repression of gene expression. In addition to serving as a general repressor for relatively large chromatin fragments, histone H1 might also be involved in controlling the transcriptional activity of individual genes.
Zlatanova
J
J
Molecular Genetics Laboratory, Bulgarian Academy of Sciences, Sofia.
D000818:Animals; D002477:Cells; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure; D004247:DNA / Q000378:metabolism; D005057:Eukaryotic Cells; D005786:Gene Expression Regulation / Q000502:physiology*; D006657:Histones / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D006657:Histones; D004247:DNA