[Effects of trihexyphenidyl on basilar artery of rabbits and cerebrovascular circulation of rats].
Trihexyphenidyl (Tri) inhibited the contraction of rabbit basilar artery due to high K+ (45.6 mmol/L). IC50 was 2.9 +/- 0.7 mumol/L. The contractions of basilar and mesenteric arteries due to calcium and those of basilar artery and saphenous vein due to serotonin were noncompetitively. Tri inhibited myogenic activities of the portal vein strips of rats and increased the normal cerebral blood flow of rats to 19 +/- 7 ml/(min.100 g).
Zhang
G Q
GQ
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Qi
M
M
Ke
J
J
Zhang
Y G
YG
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014282:Trihexyphenidyl / Q000494:pharmacology*
D014282:Trihexyphenidyl