[Alpha-1 inhibition. Prevention of coronary risk factors].
Although diuretics and beta-blockers are efficient in treating high blood pressure and in decreasing the occurrence of strokes, these therapeutics have deleterious effects concerning lipidic metabolism, therefore worsening another cardiovascular risk factor. A comparative study evaluates the effects of prazosin and atenolol on plasmatic lipids of hypertensive patients. The results of this study confirm that prazosin can avoid an increase in plasmatic lipids. This therapy could therefore be prescribed to improve the ratio risk/benefit of the hypertensive therapy.
Rouffy
J
J
Service de Médecine Interne, Hôpital Saint-Louis, Paris.
D001262:Atenolol / Q000627:therapeutic use; D003327:Coronary Disease / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors
D003692:Delayed-Action Preparations; D008055:Lipids; D001262:Atenolol; D011224:Prazosin
L'inhibition alpha 1. Prévention des facteurs de risque coronarien.