title: Enhanced elimination of piroxicam by administration of activated charcoal or cholestyramine.
abstract: This study has compared the effect of repeated administration of charcoal and cholestyramine on the elimination of piroxicam. Eight young adults were given piroxicam as a single dose of 20 mg, on 3 separate occasions. On one of the occasions charcoal was also given. On another occasion cholestyramine was also administered. The mean elimination half-life after piroxicam alone was 53.1 h. This was reduced to 40.0 h by charcoal administration and to 29.6 h after administration of cholestyramine. In the second phase of the study 7 elderly subjects received piroxicam 20 mg for 14 days on two occasions. Cholestyramine administration at the end of one of the periods reduced the mean elimination half-life of piroxicam from 52.3 h to 27.3 h.
authors.affiliation: MRC Toxicology Research Unit, University of Otago, Dunedin, New Zealand.
authors.forename: D G
authors.initials: DG
authors.lastname: Ferry
authors.forename: L R
authors.initials: LR
authors.lastname: Gazeley
authors.forename: W J
authors.initials: WJ
authors.lastname: Busby
authors.forename: D M
authors.initials: DM
authors.lastname: Beasley
authors.forename: I R
authors.initials: IR
authors.lastname: Edwards
authors.forename: A J
authors.initials: AJ
authors.lastname: Campbell
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D002606:Charcoal / Q000494:pharmacology*; D002792:Cholestyramine Resin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D002792:Cholestyramine Resin; D010894:Piroxicam; D002606:Charcoal