Bleb formation in the renal epithelial cell line LLC-PK1 exposed to N2-methyl-9-hydroxyellipticinium acetate (celiptium).
In this short communication, the authors describe the dose-dependent formation, by the antitumour drug celiptium in vitro, of blebs in pig kidney epithelial cells, illustrating it by scanning electron micrographs. The mechanism of renal injury by celiptium is discussed by a survey of the relevant literature.
Raguenez-Viotte
G
G
INSERM Unité 295, U.E.R. Médecine-Pharmacie, Rouen, France.
Fillastre
J P
JP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004611:Ellipticines / Q000494:pharmacology* / Q000633:toxicity; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D007668:Kidney / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D013552:Swine
D000970:Antineoplastic Agents; D004611:Ellipticines; C027767:elliptinium