Subclassification of peripheral dopamine receptors.
1. There is convincing evidence to suggest that two DA-receptor subtypes exist in the periphery, that can at best be differentiated by the potency of the antagonists SCH 23390 and domperidone: at DA-1 receptors the order of potency is SCH 23390 much greater than domperidone, at DA-2 receptors it is domperidone much greater than SCH 23390. 2. As in the adrenergic, muscarinic or 5-HT-receptor field, future studies employing both molecular biology and pharmacological approaches will show whether such a subclassification is sufficient to explain all peripheral effects of DA or whether DA-1 and DA-2 receptors have to be subdivided into further subtypes.
Brodde
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OE
Biochemisches Forschungslabor, Medizinische Klinik, Universitätsklinikum Essen, Germany.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000145:classification* / Q000187:drug effects / Q000378:metabolism
D001552:Benzazepines; D011954:Receptors, Dopamine; D004294:Domperidone