Specific in vitro IgG subclass synthesis and lymphocyte proliferation responses in herpes virus encephalitis.
Cerebrospinal fluid, peripheral blood lymphocytes (PBL) and sera from 5 patients with herpes simplex encephalitis (HSVE), 3 with varicellae zoster (VZV) meningoencephalitis and 5 with encephalitis of unknown origin (NUD) were analyzed. Lymphocytes from both blood and CSF were shown to synthesize anti-VZV IgG subclasses in VZV meningoencephalitis and anti-HSV IgG subclasses in HSVE. The subclass patterns of CSF and in vitro synthesized anti-viral IgG were similar, suggesting that a considerable portion of the antiviral IgG subclasses detected are synthesized in the CNS compartment. Antigen presentation in vitro seemed to produce a heterologous IgG4 and/or 3 response in 3 patients. Lymphocyte proliferation was detectable in response to HSV and VZV, respectively.
Mathiesen
T
T
Department of Virology, Karolinska Institute, Stockholm, Sweden.
Olding-Stenkvist
E
E
Linde
A
A
Olsson
O
O
Wahren
B
B
D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D002478:Cells, Cultured; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000382:microbiology; D006561:Herpes Simplex / Q000150:complications / Q000276:immunology*; D006562:Herpes Zoster / Q000150:complications / Q000276:immunology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis*; D007142:Immunoglobulin gamma-Chains / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains