Serotonin-stimulated prolactin secretion may not involve the dopaminergic system.
The possible involvement of the dopaminergic system in the serotonin (5-HT)-stimulated prolactin (PRL) secretion was tested in this study. Adult female rats were ovariectomized for two weeks and treated with estrogen (polyestradiol phosphate, 0.1 mg/rat, sc) for 6 days before use. They either received pretreatment with alpha-methyl-p-tyrosine (250 mg/kg BW, ip), a dopamine (DA) synthesis inhibitor, or two DA antagonists, domperidone and haloperidol (0.1 mg/kg BW, iv) before receiving 5-HT (1 mg/kg BW, iv) or quipazine (1 mg/kg BW, iv), a 5-HT agonist. Blockade of DA synthesis or antagonism of DA action invariably induced elevated plasma PRL levels. 5-HT or quipazine, however, could still induce significant PRL secretion on top of the increased PRL levels. Minor difference was found between the action of domperidone and that of haloperidol. In conclusion, the dopaminergic system may not be involved in the action of 5-HT to stimulate PRL secretion.
Tai
M H
MH
Institute of Physiology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
Teo
K L
KL
Pan
J T
JT
D000818:Animals; D004294:Domperidone / Q000494:pharmacology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D011954:Receptors, Dopamine; D012701:Serotonin; D004294:Domperidone; D019805:alpha-Methyltyrosine; D011388:Prolactin; D006220:Haloperidol