Motor performance decrement by midazolam: antagonism by Ro 15-1788 and CGS 8216.
Rats were trained in a fine motor control performance that required operation by a paw of a force transducer so that it remained between upper and lower limits of a force band for a continuous 1.5-sec period to deliver each food pellet. Acute doses of midazolam (0.75-3.0 mg/kg, SC) impaired indices of motor performance in a graded, dose-related fashion. When administered alone, Ro 15-1788 (0.1-5.0 mg/kg, SC) had no effect on motor behavior while CGS 8216 (0.5 and 1.0 mg/kg, IP) alone had small effects. In general, the motor performance decrements produced by midazolam were antagonized in a dose-related fashion by both Ro 15-1788 and CGS 8216.
Lau
C E
CE
Department of Psychology-Busch, Rutgers University, New Brunswick, NJ 08903.
Falk
J L
JL
Tang
M
M
D000818:Animals; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D005442:Flumazenil / Q000494:pharmacology*; D008297:Male; D008874:Midazolam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats
D011720:Pyrazoles; D001569:Benzodiazepines; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D008874:Midazolam