title: Serum CA-125 levels do not depend on ovarian steroidogenesis.
abstract: To investigate the relationship between CA-125 production and ovarian steroidogenesis, serum CA-125 levels were evaluated in patients with normal pelvis in different ovarian endocrine situations: (1) during the menstrual cycle, (2) during stimulatory treatment with gonadotropin for the induction of ovulation, and (3) during suppression treatment with gonadotropin-releasing hormone agonists. In spite of the spontaneous or the markedly induced variations of estradiol (E2) or ovarian volume, CA-125 levels remained unvaried in all patients. Moreover, CA-125 serum levels did not correlate with the increasing values of the plasma E2 or ovarian volume. In conclusion, steroidogenetic activity of the ovary is unlikely to affect CA-125 production.
authors.affiliation: Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lanzone
authors.forename: A M
authors.initials: AM
authors.lastname: Fulghesu
authors.forename: C
authors.initials: C
authors.lastname: Guida
authors.forename: R
authors.initials: R
authors.lastname: Muscatello
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002064:Buserelin / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D010060:Ovulation / Q000187:drug effects / Q000502:physiology; D012189:Retrospective Studies
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D004958:Estradiol; D002064:Buserelin