title: Theophylline plasma clearance in critically ill geriatric patients receiving total parenteral nutrition and in control patients.
abstract: Mean values and standard deviations are reported for theophylline plasma clearance in 45 hospitalized geriatric patients (age greater than 65 years), distributed into two groups: Group I (n = 24) included critically ill patients admitted to the ICU on total parenteral nutrition (TPN). Group II (n = 21) included patients admitted to the Internal Medicine Ward without TPN. All patients were treated with a constant intravenous infusion of aminophylline. Group I patients had a lower mean theophylline clearance of 0.42 +/- 0.23 ml/kg/min compared to Group II 0.64 +/- 0.24 ml/kg/min (P = 0.003).
authors.affiliation: Department of Pharmaceutical Services, Lluis Alcanyis Hospital, Xátiva, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Sangrador
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Alcaraz
authors.forename: R
authors.initials: R
authors.lastname: Ubeda
authors.forename: P
authors.initials: P
authors.lastname: Ibañez
mesh_terms: D000367:Age Factors; D000368:Aged; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000628:therapy; D010289:Parenteral Nutrition, Total; D012044:Regression Analysis; D012907:Smoking; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D013806:Theophylline