[Improvement in the effects of radiation therapy with BRM].
The effects of radiation therapy and Sonifilan (SPG; a glucan produced by Schizophyllum commune) on the control of the primary lesion of human uterine cervix cancer and the experimental metastasis with mice were studied. SPG had excellent effects on the uterine cervix cancer compared with radiation therapy alone. Furthermore, immunohistochemical study showed that tumor infiltrated monocytes in good responders were mainly occupied with helper/induced T lymphocytes. SPG also suppressed the experimental lung metastasis especially with radiation therapy. Metastatic tumor infiltrated monocytes were many macrophages, which was the same as in inoculated local tumor.
Inomata
T
T
Dept. of Radiology, Kochi Med. School.
Ogawa
Y
Y
Nishioka
A
A
Maeda
T
T
Seguchi
H
H
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary / Q000628:therapy; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D012566:Sizofiran / Q000627:therapeutic use*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy
D012566:Sizofiran