Comparison between bronchial response to inhaled hypoosmolar and isoosmolar solutions of sodium cromoglycate after exercise challenge.
The effectiveness of a sodium cromoglycate isoosmolar solution (288 mOsmol/L) versus hypoosmolar commercial solution (40 mOsmol/L) was studied in 14 asthmatic children with exercise-induced asthma. The mean FEV1 after exercise in patients pretreated with a sodium cromoglycate hypotonic solution compared with FEV1 at rest was -2% +/- 10%. The mean FEV1 after exercise in patients pretreated with an isotonic solution compared with FEV1 at rest was 3% +/- 6%. This statistically significant difference (P less than .01) proves that the effectiveness of sodium cromoglycate can be improved by raising the osmolarity to isotonic levels.
Soferman
R
R
Institute of Pulmonary and Allergic Diseases, Sackler School of Medicine, Tel Aviv University.
Kivity
S
S
Marcus
B
B
Topilsky
M
M
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests
D004205:Cromolyn Sodium