In-vitro synergy testing of nine antimicrobial combinations against Listeria monocytogenes.
In-vitro antimicrobial synergy against Listeria monocytogenes was assessed using nine combinations in chequerboard (bacteriostatic) tests and time-kill (bactericidal) studies. Ampicillin/gentamicin and trimethoprim/sulphamethoxazole were the most synergistic combinations in bacteristatic tests, whereas gentamicin with ampicillin, trimethoprim or vancomycin and trimethoprim/sulphamethoxazole were the most synergistic in bactericidal tests. Gentamicin-containing combinations were most effective at killing L. monocytogenes and those containing rifampicin least effective.
MacGowan
A P
AP
Department of Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK.
Holt
H A
HA
Reeves
D S
DS
D000900:Anti-Bacterial Agents; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008089:Listeria monocytogenes / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents