title: Synthesis of two new angiotensin II analogs.
abstract: The synthesis of two new angiotensin II analogs: [Des-Arg2, epsilon Ahx1]-angiotensin (II (1) and [Des-His0)-angiotensin (II (2) is reported. Rather strong agonist activity shows analog (1)-78% and weak-analog (2)-30% of the contractile activity of angiotensinamide. None of the synthesized peptides has antagonist activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Medical Academy, Warszawa, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Paruszewski
authors.forename: R
authors.initials: R
authors.lastname: Matusiak
authors.forename: W
authors.initials: W
authors.lastname: Janiec
authors.forename: J
authors.initials: J
authors.lastname: Folwarczna
authors.forename: L
authors.initials: L
authors.lastname: Sliwiński
authors.forename: M
authors.initials: M
authors.lastname: Pytlik
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II