title: Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.
abstract: RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.
authors.affiliation: Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Shimotohno
authors.forename: D
authors.initials: D
authors.lastname: VanLeeuwen
authors.forename: M
authors.initials: M
authors.lastname: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002822:Choriocarcinoma / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007256:Information Systems; D008667:Metalloproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011533:Proviruses / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics; D014158:Transcription, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*; D015032:Zinc / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D008667:Metalloproteins; D012333:RNA, Messenger; D004247:DNA; D015032:Zinc