Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.
Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation.
Wright
J J
JJ
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Gunter
K C
KC
Mitsuya
H
H
Irving
S G
SG
Kelly
K
K
Siebenlist
U
U
D000595:Amino Acid Sequence; D002460:Cell Line; D002472:Cell Transformation, Viral; D004268:DNA-Binding Proteins / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics*; D006801:Humans; D008667:Metalloproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D013601:T-Lymphocytes; D015678:Viral Structural Proteins / Q000235:genetics*; D015032:Zinc / Q000378:metabolism*
D004268:DNA-Binding Proteins; D008667:Metalloproteins; D015678:Viral Structural Proteins; D015032:Zinc