title: Biological activity of two photoactive benzocoumarins.
abstract: The effect on DNA synthesis in cell cultures exerted by two photoactive benzocoumarins were studied. A favourable ratio between inhibition of DNA synthesis and the irradiation time periods was found in these compounds. This activity is substantially due to their ability to produce a monofunctional adduct with DNA.
authors.affiliation: Institute of Pharmacology and Experimental Therapy, University of Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Dianzani
authors.forename: L
authors.initials: L
authors.lastname: Silvestro
authors.forename: I
authors.initials: I
authors.lastname: Viano
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003374:Coumarins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D011564:Furocoumarins / Q000494:pharmacology; D008730:Methoxsalen / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D003374:Coumarins; D011564:Furocoumarins; C069509:3H-naphtho(2,1-b)pyran-3-one; D004247:DNA; C069508:9-(3-diethylaminopropyloxy)-3H-naphtho(2,1-b)pyran-3-one; C011659:angelicin; D008730:Methoxsalen