The thyroglobulin gene is syntenic with the MYC and MOS protooncogenes and carbonic anhydrase II and maps to chromosome 14 in cattle.
Using a panel of bovine x Chinese hamster hybrid somatic cells, sequences homologous to genes spanning human chromosome arm 8q have been syntenically assigned in cattle. Thyroglobulin (TG), carbonic anhydrase II (CA2), and the protooncogenes MYC and MOS were assigned to a newly identified bovine syntenic group, U23. Additionally, in situ hybridization of the thyroglobulin probe to bovine metaphase chromosomes revealed this syntenic group to be on bovine chromosome 14 and the bovine thyroglobulin gene to reside at 14q12----q15.
Threadgill
D W
DW
Department of Veterinary Pathology, Texas A & M University, College Station 77843.
Fries
R
R
Faber
L K
LK
Vassart
G
G
Gunawardana
A
A
Stranzinger
G
G
Womack
J E
JE
D000818:Animals; D001345:Autoradiography; D015139:Blotting, Southern; D002256:Carbonic Anhydrases / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D006224:Cricetinae; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes / Q000235:genetics*; D013954:Thyroglobulin / Q000235:genetics*
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D013954:Thyroglobulin; D002256:Carbonic Anhydrases