[Experimental validation of the use of RNA hydrolysate (ENKAD) in chemical burns of the cornea].
The influence of ENKAD on the course of a severe alkaline burn of the cornea was studied in 158 rabbits (316 eyes). Cytochemically, regularity in correlations of separate amino acids: cystin, cysteine, arginine and glutaminic acid in cellular proteins of the intact cornea was established and their disorder in dynamics of the burn process is shown. Comparative assessment of therapeutic effectiveness of ultrasound, applications, subconjunctival injections and phonophoresis of ENKAD has shown that a combined usage of ultrasound and ENKAD has the most expressed positive action on the course of the burn process of the corneal burn, such as acceleration of corneal epithelialization that accomplished, on the average, by the 9.3 +/- 0.3 day (in the control--by the 20.8 +/- 1.8 day), rapid disappearance of its perifocal edema--11.05 +/- 0.7 (in the control - 29.7 +/- 1.1) day, better outcomes after the burn (in 37.5% of cases superficial limited opacifications were formed, in the control--in 7.1%). One of the factors of therapeutic action of ENKAD phonophoresis is its normalizing influence on disturbed correlation of amino acids in proteins. The results obtained allow to recommend to include ENKAD phonophoresis into a complex treatment of patients with eye burns.
Andrushkova
O A
OA
Plevinskikh
V P
VP
Iakimenko
S A
SA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000188:drug therapy* / Q000378:metabolism; D003228:Conjunctiva; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D065306:Corneal Injuries; D004353:Drug Evaluation, Preclinical; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D006651:Histocytochemistry; D007267:Injections; D009843:Oligoribonucleotides / Q000008:administration & dosage / Q000627:therapeutic use*; D015612:Phonophoresis; D011817:Rabbits; D012265:Ribonucleotides / Q000008:administration & dosage / Q000627:therapeutic use*; D014464:Ultrasonic Therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009843:Oligoribonucleotides; D012265:Ribonucleotides; C031373:ENKAD
Eksperimental'noe obosnovanie primeneniia gidrolizata RNK (ENKAD) pri khimicheskikh ozhogakh rogovitsy.