title: Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukaemia.
abstract: Gonadal function was assessed in 15 boys with acute lymphoblastic leukaemia (ALL) who had received testicular irradiation. The dose to the testes was 12 Gy in 12, 15 Gy in 1, and 24 Gy in 2 cases. All of those who had received 12 or 15 Gy had normal Leydig cell function, although high levels of gonadotropins suggest subclinical Leydig cell damage. The 2 who had 24 Gy had Leydig cell failure. All who were old enough to produce a semen specimen were azoospermic.
authors.affiliation: Royal Victoria Infirmary, Newcastle upon Tyne, England.
authors.forename: L A
authors.initials: LA
authors.lastname: Castillo
authors.forename: A W
authors.initials: AW
authors.lastname: Craft
authors.forename: J
authors.initials: J
authors.lastname: Kernahan
authors.forename: R G
authors.initials: RG
authors.lastname: Evans
authors.forename: A
authors.initials: A
authors.lastname: Aynsley-Green
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000532:radiotherapy*; D011863:Radioimmunoassay; D011879:Radiotherapy Dosage; D012661:Semen / Q000032:analysis; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone