title: Free haemagglutinin in inactivated whole virus influenza vaccines.
abstract: While studying the haemagglutinin content of whole virus inactivated influenza vaccines by the single radial diffusion test and quantitative electron microscopy, it was found that not all haemagglutinin measured by single radial diffusion was bound to virions, a part of it being in a free state. The influence of unbound haemagglutinin on the immunogenicity of whole virus inactivated influenza vaccine is discussed. In addition, the use of single radial diffusion for the assessment of unbound haemagglutinin is suggested.
authors.affiliation: Tarassevich State Research Institute for Standardization and Control of Medical Biological Preparations, Moscow, U.S.S.R.
authors.forename: L N
authors.initials: LN
authors.lastname: Kastrikina
authors.forename: V I
authors.initials: VI
authors.lastname: Minaev
authors.forename: N I
authors.initials: NI
authors.lastname: Lonskaya
authors.forename: G I
authors.initials: GI
authors.lastname: Bizhanov
mesh_terms: D002850:Chromatography, Gel; D006389:Hemagglutinins, Viral / Q000032:analysis* / Q000276:immunology; D005779:Immunodiffusion; D007252:Influenza Vaccines / Q000032:analysis*; D008854:Microscopy, Electron; D015164:Vaccines, Inactivated / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis; D014771:Virion / Q000032:analysis
chemical_list: D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D014764:Viral Proteins