Gallium-67/stable gadolinium antagonism: MRI contrast agent markedly alters the normal biodistribution of gallium-67.
An 11-yr-old patient was scanned 96 hr after the administration of gallium-67 (67Ga). The scan emulated the biodistribution of a typical bone-seeking radipharmaceutical-rather than that of 67Ga. None of the factors previously identified with alteration of the biodistribution of 67Ga were found. However, the patient had been injected with gadopentetate in conjunction with magnetic resonance imaging 4 hr before receiving the 67Ga. Gadolinium appears to cause a strong carrier-like effect in 67Ga scans.
Hattner
R S
RS
Deparmtent of Radiology, University of California, San Francisco 94143-0252.
White
D L
DL
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000000981:diagnostic imaging*; D002648:Child; D004347:Drug Interactions; D005682:Gadolinium / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D014915:Whole-Body Counting
D005710:Gallium Radioisotopes; D005682:Gadolinium