Influence of branched chain amino acid infusions on wound healing.
Branched chain amino acids (BCAA) may serve as a major oxidative fuel for skeletal muscle during periods of starvation. This study compared the ability of protein-undernourished rats to heal musculo-aponeurotic wounds of the abdominal wall when they were infused with solutions containing 45% BCAA or 8% BCAA (conventional TPN). Although the provision of 45% BCAA tended to result in better nourished animals and significantly increased plasma glutamine concentrations, this was not associated with improved healing.
McCauley
R
R
University Department of Surgery, Royal Perth Hospital, Western Australia.
Platell
C
C
Hall
J
J
McCulloch
R
R
D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007262:Infusions, Intravenous; D007813:Laparotomy; D008297:Male; D010289:Parenteral Nutrition, Total; D011502:Protein-Energy Malnutrition / Q000503:physiopathology / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000597:Amino Acids, Branched-Chain