Alteration of intestinal enzyme activities associated with extensive large-colon resection in horses.
Lactase, maltase, sucrase, and alkaline phosphatase activities were determined in the intestinal mucosa from 3 locations in the small intestine and 4 locations in the large intestine 1 year after extensive large-colon resection (group 1; n = 5) and 1 year after sham operation (group 2; n = 3) in horses. Lactase, maltase, and sucrase activities were similar (P greater than 0.05) between group-1 and group-2 horses in all locations measured in the intestinal tract. Alkaline phosphatase activity in the remaining large colon of group-1 horses was significantly (P less than 0.05) greater than the activity in the large colon of group-2 horses. Decreased apparent digestion of phosphorus and a negative phosphorus balance are persistent features of large-colon resection in horses. Increases in alkaline phosphatase activity in the remaining colon of horses with extensive large-colon resection may be a specific functional adaptive mechanism that attempts to counteract the derangements in phosphorus metabolism.
Bertone
A L
AL
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Toofanian
F
F
Stashak
T S
TS
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D003082:Colectomy / Q000662:veterinary; D003106:Colon / Q000201:enzymology / Q000601:surgery; D005260:Female; D005696:Galactosidases / Q000378:metabolism*; D006736:Horses / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000601:surgery; D007420:Intestine, Large / Q000201:enzymology* / Q000601:surgery; D007421:Intestine, Small / Q000201:enzymology*; D008297:Male; D013393:Sucrase / Q000378:metabolism*; D013997:Time Factors; D000520:alpha-Glucosidases / Q000378:metabolism*; D001616:beta-Galactosidase / Q000378:metabolism*
D000469:Alkaline Phosphatase; D005696:Galactosidases; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase