The lupus anticoagulant, anticardiolipin antibodies, and recurrent miscarriage.
The presence of antibodies to cardiolipin and the lupus anticoagulant were investigated in 189 couples with recurrent abortion. Abnormal coagulation results as measured by an elevation of the APTT or KCT were found in 6% and 7% of patients, respectively; however, the lupus anticoagulant was detected in only 3% of patients. Anticardiolipin antibody levels higher than normal were found in 15% of patients. There was no significant difference between parameters in primary as compared to secondary recurrent aborters or subfertile compared to fertile recurrent aborters. The success of the next pregnancy could not be predicted by any of the laboratory tests.
Taylor
M
M
Department of Haematology and Immunology, Royal Women's Hospital, Melbourne, Australia.
Cauchi
M N
MN
Buchanan
R R
RR
D000026:Abortion, Habitual / Q000209:etiology / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids / Q000276:immunology*; D011247:Pregnancy; D012008:Recurrence
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids