title: Photodynamic therapy in lung and gastrointestinal cancers.
abstract: Twelve central bronchial carcinoma patients and two gastrointestinal (GI) tract (oesophageal and colonic) early-stage cancer patients were treated with photodynamic therapy (PDT). Haematoporphyrin (HP/5, Jacopo Monico, Italy) at a dose of 5 mg kg-1 body weight was used as photosensitizer. Laser light at 628.2-630 nm generated by two different laser systems (gold vapour laser (I.P. Optics, Sofia, Bulgaria) in lung cancer cases and an argon dye laser system (Spectra Physics, Mountain View, U.S.A.) in GI tract cancers) was used. Lung cancers were irradiated 48 h after drug administration and GI tract cancers were irradiated 72 h after infusion of the photosensitizer. Both tumour sites were treated with a total energy dose in the range 350-600 J cm-2. Efficiency of PDT in lung cancer was evaluated by X-rays and endoscopic and functional respiratory tests for bronchial de-obstruction. Complete remission after PDT of GI tract cancers was considered to be tumour eradication (histologically and cytologically proved) and a tumour-free interval of at least 12 months.
authors.affiliation: Department of Surgery and Endoscopy, Bulgarian Medical Academy, Sofia.
authors.forename: S
authors.initials: S
authors.lastname: Karanov
authors.forename: D
authors.initials: D
authors.lastname: Kostadinov
authors.forename: M
authors.initials: M
authors.lastname: Shopova
authors.forename: P
authors.initials: P
authors.lastname: Kurtev
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy* / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D007834:Lasers; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010778:Photochemotherapy
chemical_list: D000970:Antineoplastic Agents; D006415:Hematoporphyrins; C066095:hematoporphyrin HP-5