title: The efficacy of tobramycin in the treatment of ulcerative colitis.
abstract: This paper reports a double-blind placebo-controlled trial of oral tobramycin in acute ulcerative colitis. Eighty-four patients with an acute relapse of ulcerative colitis were randomized to receive oral tobramycin or placebo for 1 week as an adjunct to steroid therapy. At endpoint, 31 of 42 (74%) in the tobramycin group achieved complete symptomatic remission compared with 18 of 42 (43%) in the placebo group (P = 0.008). The tobramycin group achieved better histological scores (P less than 0.05) at endpoint. These findings show that treatment with oral tobramycin improves the short-term outcome of patients with ulcerative colitis in relapse.
authors.affiliation: Gastroenterology Unit, General Infirmary, Leeds, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Burke
authors.forename: A T
authors.initials: AT
authors.lastname: Axon
authors.forename: S A
authors.initials: SA
authors.lastname: Clayden
authors.forename: M F
authors.initials: MF
authors.lastname: Dixon
authors.forename: D
authors.initials: D
authors.lastname: Johnston
authors.forename: R W
authors.initials: RW
authors.lastname: Lacey
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014031:Tobramycin / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D014031:Tobramycin