The antiatherogenic effects of components isolated from pollen typhae.
Based on the results of previous investigations that pollen Typhae, a Traditional Chinese Medicine, Had antiatherogenic effects, several components were isolated successively from the drug and their effects on porcine aortic endothelial cell (EC) and smooth muscle cell (SMC) cultures as well as on platelet aggregation were examined. 12 components isolated from Pollen Typhae have been identified on their chemical structures and biological effects. 4 of them showed different evident antiatherogenic effects. 1) Isorhamnetin-3-O-rhamnosyl-glucoside could stimulate EC to produce tPA and PGI2; 2) Quercetin-3-O-neohesperidose could protect EC from injury by fibrin, as well as raise tPA activity; 3) beta-Sitosterol palmitate could inhibit SMC proliferation and 4) beta-Sitosterol glucoside showed an inhibitory effect on platelet aggregation. These results would provide some information for the search of new drugs in the treatment and prevention of atherosclerosis.
Zhao
J
J
Shanghai Ins. of Hematol., Shanghai 2nd Med. Univ., China.
Zhang
C Y
CY
Xu
D M
DM
Huang
G Q
GQ
Xu
Y L
YL
Wang
Z Y
ZY
Fang
S D
SD
Chen
Y
Y
Gu
Y L
YL
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004187:Disaccharides / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D011464:Epoprostenol / Q000096:biosynthesis*; D005337:Fibrin / Q000494:pharmacology; D044948:Flavonols; D006569:Hesperidin / Q000031:analogs & derivatives / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors; D011058:Pollen / Q000032:analysis*; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D012855:Sitosterols / Q000494:pharmacology; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*
D004187:Disaccharides; D004365:Drugs, Chinese Herbal; D044948:Flavonols; D010975:Platelet Aggregation Inhibitors; D012855:Sitosterols; C064869:quercetin-3-O-neohesperidose; C025473:gamma-sitosterol; C064868:isorhamnetin-3-O-rhamnosyl(1-2)glucoside; D005337:Fibrin; D011794:Quercetin; D011464:Epoprostenol; D006569:Hesperidin; D010959:Tissue Plasminogen Activator