6-Hydroxydopamine lesions of the olfactory tubercle do not alter (+)-amphetamine-conditioned place preference.
Rats received bilateral infusions of 6-hydroxydopamine into the olfactory tubercle, resulting in a substantial (89%) local depletion of dopamine. This treatment did not significantly alter conditioned place preference produced by (+)-amphetamine, suggesting that the mesolimbic dopaminergic projection to olfactory tubercle does not mediate the rewarding effects of (+)-amphetamine in rats.
Clarke
P B
PB
Department of Pharmacology and Therapeutics, McGill University, Montral, Canada.
White
N M
NM
Franklin
K B
KB
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001931:Brain Mapping; D002755:Choice Behavior / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects*; D009833:Olfactory Pathways / Q000187:drug effects; D009949:Orientation / Q000187:drug effects*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D000661:Amphetamine; D004298:Dopamine; D009638:Norepinephrine