Monosomy 7, leukaemia and immunoglobulin heavy chain gene rearrangement.
We describe the haematological findings and clinical course of a 15-year-old male who presented with a spontaneous acute lymphoblastic leukaemia. The lymphoid origin of the leukaemia was supported by cell surface antigen studies and immunoglobulin heavy chain gene analysis. Bone marrow karyotype was simple monosomy 7 and the lymphoblasts expressing the myeloid associated antigen CD 33. Both of these features have been previously shown to indicate a poor prognosis. The findings in this patient support a previous hypothesis that monosomy 7 can arise at the stem cell level.
Barnett
D
D
Department of Haematology, Northern General Hospital, Sheffield, England.
Wodzinski
M A
MA
Watmore
A
A
D000293:Adolescent; D002897:Chromosomes, Human, Pair 7; D015321:Gene Rearrangement / Q000235:genetics*; D006651:Histocytochemistry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D016130:Immunophenotyping; D007621:Karyotyping; D008297:Male; D009006:Monosomy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains