title: HLA DQ alpha/beta molecule associated with the susceptibility to insulin-dependent diabetes mellitus. A model for HLA/autoimmune disease association.
abstract: We have proposed a molecular model of susceptibility to Insulin-Dependent Diabetes Mellitus (IDDM) based on the proportional expression at the cell surface of the following susceptible (S-S) HLA-DQ heterodimere composed of a chain DQ alpha Arg 52 positive (S) and a chain HLA-DQ beta Asp 57 negative (S). All other DQ alpha/beta chains associations are considered as protective molecules. This model allows a predictive scale of risk for the disease.
authors.affiliation: INSERM U93, Hôpital Saint-Louis, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Khalil
authors.forename: I
authors.initials: I
authors.lastname: Deschamps
authors.forename: V
authors.initials: V
authors.lastname: Lepage
authors.forename: L
authors.initials: L
authors.lastname: Morin
authors.forename: F
authors.initials: F
authors.lastname: Galibert
authors.forename: L
authors.initials: L
authors.lastname: Degos
authors.forename: J
authors.initials: J
authors.lastname: Hors
mesh_terms: D000483:Alleles; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D012306:Risk
chemical_list: D006683:HLA-DQ Antigens