title: Left ventricular dysfunction following ligation of the ductus arteriosus in the preterm baboon.
abstract: We evaluated the effect of early closure of the patent ductus arteriosus (PDA) on cardiac performance in a preterm baboon model of hyaline membrane disease. Eleven baboon fetuses were delivered at 75% gestation, resuscitated, and treated with conventional ventilation. The animals were divided into two groups, and underwent left thoracotomy at 2 hr of age. Group 1 (N = 5) had ductal infiltration with formalin to maintain ductal patency. Group 2 (N = 6) had ductal ligation. Hemodynamic parameters were compared between groups before and after surgical intervention. Examination of cardiovascular function was performed at intervals over a 24-hr period using two-dimensional, M-mode, and pulsed Doppler echocardiography. Ventricular performance was significantly worse in the ligation animals as demonstrated by reduced left and right ventricular outputs and reduced left ventricular shortening. However, pulmonary disease and arterial blood gases were not different. Early ligation was also associated with significantly increased systemic vascular resistance. We conclude that early ductal ligation leads to impaired ventricular performance in the premature primate. We hypothesize that the PDA may protect the immature ventricle by preventing pressure overload during adaptation to postnatal life.
authors.affiliation: Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
authors.forename: A F
authors.initials: AF
authors.lastname: Taylor
authors.forename: W R
authors.initials: WR
authors.lastname: Morrow
authors.forename: K P
authors.initials: KP
authors.lastname: Lally
authors.forename: J P
authors.initials: JP
authors.lastname: Kinsella
authors.forename: D R
authors.initials: DR
authors.lastname: Gerstmann
authors.forename: R A
authors.initials: RA
authors.lastname: deLemos
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004374:Ductus Arteriosus, Patent / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology*; D008026:Ligation; D009200:Myocardial Contraction; D010100:Oxygen / Q000097:blood; D010215:Papio; D011183:Postoperative Complications; D011652:Pulmonary Circulation; D014655:Vascular Resistance
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen