title: Pregnancy following combined growth hormone--pulsatile GnRH treatment in a patient with hypothalamic amenorrhoea.
abstract: A patient with hypothalamic amenorrhoea and a poor response in terms of pituitary growth hormone (GH) to acute administration of growth hormone-releasing factor has been treated with pulsatile gonadotrophin-releasing hormone (GnRH) combined with GH to induce ovulation. GH was administered daily until signs of ovulation were detected. The luteal phase was supported by pulsatile GnRH only. Combined treatment gave an improved follicular recruitment, higher plasma levels of 17 beta-oestradiol and an earlier ovulation, compared to the previous cycle with pulsatile GnRH only. The result was a twin pregnancy which ended with the birth of two healthy male babies. The role of GH in potentiating the ovarian response to gonadotrophins, as well as the GH secretion abnormalities associated with dysfunctions of the hypothalamic - pituitary - gonadal axis, might provide a rationale for combined GH and pulsatile GnRH treatment in such patients.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Modena, Policlinico, Via del Pozzo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Volpe
authors.forename: G
authors.initials: G
authors.lastname: Coukos
authors.forename: P G
authors.initials: PG
authors.lastname: Artini
authors.forename: M
authors.initials: M
authors.lastname: Silferi
authors.forename: F
authors.initials: F
authors.lastname: Petraglia
authors.forename: M
authors.initials: M
authors.lastname: Boghen
authors.forename: G D
authors.initials: GD
authors.lastname: D'Ambrogio
authors.forename: A R
authors.initials: AR
authors.lastname: Genazzani
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D013007:Growth Hormone-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D010062:Ovulation Induction; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000187:drug effects*; D011673:Pulsatile Flow
chemical_list: D004958:Estradiol; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone