[Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract].
Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically. A high concentration (0.075%) FR74366 showed sufficient effects both to prevent and reverse cataract, but low concentrations (0.025%) FR74366 was not effective as 0.075% FR74366. These results indicate that FR74366 can be useful drug for cataract.
Tsuji
T
T
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Matsumoto
Y
Y
Mori
K
K
Ikebe
H
H
Terubayashi
H
H
Akagi
Y
Y
Tanimoto
T
T
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005690:Galactose; D011799:Quinazolines / Q000627:therapeutic use*; D051381:Rats; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D011799:Quinazolines; C064920:FR 74366; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; D005690:Galactose