title: [Macrophages from healthy adults release TNF-alpha after exposure to Pneumocystis carinii of murine origin. Preliminary study].
abstract: The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.
authors.affiliation: Istituto di Clinica delle Malattie Infettive, Università Cattolica del S. Cuore, Roma.
authors.forename: E
authors.initials: E
authors.lastname: Tamburrini
authors.forename: A
authors.initials: A
authors.lastname: De Luca
authors.forename: G
authors.initials: G
authors.lastname: Ventura
authors.forename: G
authors.initials: G
authors.lastname: Maiuro
authors.forename: A
authors.initials: A
authors.lastname: Siracusano
authors.forename: E
authors.initials: E
authors.lastname: Ortona
authors.forename: A
authors.initials: A
authors.lastname: Antinori
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011010:Pneumocystis / Q000276:immunology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D014409:Tumor Necrosis Factor-alpha
vernacular_title: Macrofagi di soggetti adulti sani rilasciano TNF-alfa dopo esposizione a Pneumocystis carinii di origine murina. Studio preliminare.