title: Ultrasound monitoring of testis and prostate maturation in hypogonadotropic hypogonadic males during gonadotropin-releasing hormone treatment.
abstract: The effects of the administration of gonadotropin-releasing hormone (GnRH) on the increase of testis and prostate volume was monitored by ultrasound in six patients affected by idiopathic hypogonadotropic hypogonadism. A significant increase of testis volume was observed after 90 and 180 days (6.65 versus 3.32 mL, 99.1% net increase and 8.47 mL, 176.8% increase, respectively) of pulsatile GnRH treatment. A similar increase of prostate volume was observed at day 90 (12.67 versus 7.78 mL, 70.3% net increase) and day 180 (14.70 mL, 97.7% increase). The ultrasound monitoring of the modifications of testis and prostate volume may represent a biological assay of the effects of GnRH treatment and offer additional data on the response of target organs to the hormonal treatment.
authors.affiliation: Postgraduate School of Andrology, University of Pisa Medical School, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Canale
authors.forename: V
authors.initials: V
authors.lastname: Mais
authors.forename: P
authors.initials: P
authors.lastname: Turchi
authors.forename: F
authors.initials: F
authors.lastname: Andreini
authors.forename: G B
authors.initials: GB
authors.lastname: Melis
authors.forename: G F
authors.initials: GF
authors.lastname: Menchini-Fabris
mesh_terms: D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use*; D011467:Prostate / Q000187:drug effects / Q000473:pathology*; D013737:Testis / Q000187:drug effects / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D006062:Gonadotropins; D010906:Pituitary Hormone-Releasing Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone