Chromosome abnormalities of gastric cancer detected in cancerous effusions.
The chromosomes were examined in cancerous effusions obtained from 7 patients with gastric cancer. In 1 patient, the modal chromosome number was 46 with a normal chromosome complement in the majority of the cells examined. The other 6 patients revealed numerical and structural aberrations. Among the structural rearrangements detected, chromosome 3 was involved in the short arm and in the long arm, each in three patients; bands p25, q21, q23, and q27 were recurrently involved and a band q23 was lost in 3 patients. Rearrangements of chromosome 5 in the long arm and of chromosome 17 at or near the centromere were also observed in three patients each. Gains of chromosome 7 was seen in 5 patients and of chromosome 13 in 4. Some of these alterations may be specific for gastric cancer.
Misawa
S
S
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Horiike
S
S
Taniwaki
M
M
Tsuda
S
S
Okuda
T
T
Kashima
K
K
Abe
T
T
Sugihara
H
H
Noriki
S
S
Fukuda
M
M
D000328:Adult; D001202:Ascitic Fluid / Q000235:genetics; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*