title: 99mTc-human immunoglobulin (HIG)--first results of a new agent for the localization of infection and inflammation.
abstract: Technetium (99mTc) labelled, polyclonal human immunoglobulin (HIG) is a new agent that detects focal infection and inflammation. This new agent was compared in 40 patients with the accepted standard, namely 111In-oxine-labelled leucocytes. This comparison resulted in a sensitivity of 94% and a specificity of 96% for 99mTc-HIG when 111In-oxine leucocytes were defined as giving the true result. The new agent was shown to localize both sepsis and active inflammatory bowel disease (IBD). There was 100% concordance in the 16 patients with IBD who were imaged with both 99mTc-HIG and 111In-oxine leucocytes. Discordant results were obtained in one case of suspected osteomyelitis, which was false-positive on the 99mTc-HIG scan, and one case of pyrexia of unknown origin when the 99mTc-HIG was false-negative and the 111In-oxine leucocyte scan demonstrated accumulation of tracer in the caecum at 24 h post-injection. Normal distribution for 99mTc-HIG demonstrated activity in the kidneys and bladder and that 50% of the tracer is cleared through the kidneys during the first 24 h post-injection. There were no major or minor side-effects.
authors.affiliation: Institute of Nuclear Medicine, University College and Middlesex School of Medicine, London, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Buscombe
authors.forename: D
authors.initials: D
authors.lastname: Lui
authors.forename: G
authors.initials: G
authors.lastname: Ensing
authors.forename: R
authors.initials: R
authors.lastname: de Jong
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
mesh_terms: D001424:Bacterial Infections / Q000000981:diagnostic imaging*; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins; D007205:Indium Radioisotopes; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D007136:Immunoglobulins; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C065376:technetium Tc 99m immunoglobulin; C032950:indium oxine; D015125:Oxyquinoline; D013667:Technetium