title: [Synthesis and antitumor activity of new analogs of anthracycline antibiotics modified by aglycon].
abstract: Anthracycline antibiotics widely used, along with their semisynthetic analogues, in human cancer chemotherapy, are O-glycosides having as aglycon 7,8,9,10-tetrahydronaphtacenequinone-5,10-with some hydroxy groups, a side chain at C-9 and sugar(s) residues, usually at C-7. The review includes the most important studies on the chemical modification of the aglycon moiety of daunorubicin, doxorubicin and carminomycin during last ten years. Activity of the compounds on experimental tumours is described and their structure-activity relationship is discussed.
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents
vernacular_title: Sintez i protivopukholevaia aktivnost' novykh analogov antratsiklinovykh antiviotikov, modifitsirovannykh po aglikonu.