Interferon-gamma and the sexual dimorphism of autoimmunity.
The sexual difference in the incidence of autoimmune diseases has remained an enigma for many years. In the examination of the induction of autoimmunity in transgenic mice, evidence has been obtained further implicating the lymphokine interferon-gamma in the etiology of autoimmunity. Sex steroid regulation of the production of this molecule, as well as other cytokines, may help explain the gender-specific differences in the immune system, including autoimmunity.
Sarvetnick
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Department of Developmental Biology, Genetech, Inc., South San Francisco, CA 94080.
Fox
H S
HS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000503:physiopathology*; D015551:Autoimmunity; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D012739:Gonadal Steroid Hormones / Q000494:pharmacology / Q000502:physiology; D006649:Histocompatibility Antigens / Q000096:biosynthesis; D006801:Humans; D007108:Immune Tolerance; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000494:pharmacology / Q000502:physiology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology; D008954:Models, Biological; D009928:Organ Specificity; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011987:Receptors, Steroid / Q000032:analysis; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens; D016207:Cytokines; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D006649:Histocompatibility Antigens; D011987:Receptors, Steroid; D011993:Recombinant Fusion Proteins; D007371:Interferon-gamma