[The apomorphine test for diagnosis of parkinsonian syndrome].
Apomorphine is a powerful dopaminergic drug, able to improve cardinal symptoms of Parkinson's disease in few minutes, when injected subcutaneously. We administered different doses of apomorphine s.c. against placebo in 25 patients with a Parkinsonian syndrome, with the aim of discriminating Parkinson's disease from other Parkinsonism. A positive response to apomorphine was predictive (88%) of good responsiveness to levodopa therapy. Our data, together with those of other groups, indicate that apomorphine test is a useful tool in the diagnosis of Parkinsonian syndromes.
Piccini
P
P
Istituto di Clinica Neurologica, Università di Pisa.
Del Dotto
P
P
Napolitano
A
A
Pardini
C
C
Bonuccelli
U
U
D000368:Aged; D001058:Apomorphine; D003937:Diagnosis, Differential; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy; D010302:Parkinson Disease, Secondary / Q000175:diagnosis* / Q000188:drug therapy
D007980:Levodopa; D001058:Apomorphine
Il test all'apomorfina nella diagnosi delle sindromi parkinsoniane.