Prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery, a comparative placebo controlled clinical trial.
A clinical double-blind placebo controlled trial was carried out in 136 patients to test the value of the prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery. The three patient groups were uniform with regard to the background data such as age and weight of the patients and the clinical status of the operated tooth, as well as to the observations made at surgery. No statistically significant differences were found between the study groups in the parameters used for evaluation. The results indicate that neither penicillin nor tinidazole have more effect on postoperative complications following operative extraction of wisdom teeth, than placebo tablets.
Happonen
R P
RP
Institute of Dentistry, University of Turku, Finland.
Bäckström
A C
AC
Ylipaavalniemi
P
P
D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D008297:Male; D008334:Mandible; D008964:Molar, Third / Q000601:surgery*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010404:Penicillin V / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D014011:Tinidazole / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects*
D009593:Nitroimidazoles; D014011:Tinidazole; D010404:Penicillin V