MRI findings in the mild type of mucopolysaccharidosis II (Hunter's syndrome).
Neuroradiological findings in a 44-year-old male with the typical mild type of Hunter's disease are reported. Cranial MRI revealed patchy areas of increased and decreased signals in T1- and T2-weighted images in the thalamus and the basal ganglia giving rise to a honey comb-like appearance as a whole. The deep white matter showed high signals in the T2-weighted image. To our knowledge, the honey comb-like appearance has never been reported in this disorder. Deposition of mucopolysaccharides and/or glycolipids and increase in fluid content seem to be responsible for these changes.
Shimoda-Matsubayashi
S
S
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Kuru
Y
Y
Sumie
H
H
Ito
T
T
Hattori
N
N
Okuma
Y
Y
Mizuno
Y
Y
D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016532:Mucopolysaccharidosis II / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed