Effect of dopamine depletion upon the K(+)-evoked release of CCK from superfused striatal slices.
The effect of a lack of dopamine (DA) in the striatum upon the K(+)-evoked release of cholecystokinin (CCK) from superfused rat striatal slices has been studied. Two pharmacological tools were used to deplete the nigrostriatal DA system: administration of alpha-methyl-p-tyrosine which competitively inhibits DA synthesis and lesions with 6-hydroxydopamine of the medial forebrain bundle. In both cases there was a significant inhibition of the K(+)-evoked release of CCK. The observed effects might be relevant on pathological conditions implying depletion of the DA system.
Sierralta
J
J
Department of Cell and Molecular Biology, Catholic University, Santiago, Chile.
Gysling
K
K
D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D006892:Hydroxydopamines; D066298:In Vitro Techniques; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009498:Neurotoxins; D016627:Oxidopamine; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D019805:alpha-Methyltyrosine
D006892:Hydroxydopamines; D008781:Methyltyrosines; D009498:Neurotoxins; D019805:alpha-Methyltyrosine; D016627:Oxidopamine; D002766:Cholecystokinin; D011188:Potassium; D004298:Dopamine