Tyrosine phosphorylation and the regulation of cell growth: growth factor-stimulated tyrosine phosphorylation of phospholipase C.
The significance of tyrosine phosphorylation in cell growth and transformation has been addressed. While the details of how tyrosine kinases actually function in mitogenic signal transduction is not fully understood, recent evidence suggests that phosphoinositide metabolism may have a significant role in growth factor signal transduction. Interestingly, one of phosphatidylinositol-specific phospholipase C isozymes is an excellent substrate for growth factor receptor tyrosine kinases. In this review, the current understanding of growth factor-mediated phosphoinositide metabolism and tyrosine phosphorylation of phospholipase C, is discussed.
Nishibe
S
S
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN 37232-0146.
Carpenter
G
G
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D010738:Type C Phospholipases / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D006133:Growth Substances; D014443:Tyrosine; D010738:Type C Phospholipases