Relationship between schistosomicidal drug efficacy, gonadal steroid hormonal changes and state of disease immunopathology in murine schistosomiasis mansoni.
The schistosomicidal efficacy of praziquantel (2 x 500 mg/kg), oxamniquine (1 x 100 mg/kg) and combined one-third the curative dose of each of them (333 mg/kg praziquantel + 33 mg/kg oxamniquine), were correlated to gonadal steroid hormonal changes and state of disease immunopathology, in mice infected with 100 Schistosoma mansoni (S. mansoni) cercariae. Maximum efficacy recorded with combination regimen particularly 4 weeks after treatment, was accompanied by maximum reduction in granuloma volume (65%), least fall in testosterone level (-56.2 and -60.2% in male and female mice respectively) and increased progesterone level (+33.9 and +81.5% in male and female mice respectively). These findings revealed a potentiated effect of combination therapy on mature infection and the possible involvement of gonadal steroid hormones in affecting the efficacy of schistosomicidal drugs and state of disease immunopathology.
Botros
S S
SS
Pharmacology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt.
Salama
S H
SH
Estafan
M Y
MY
Gomaa
N E
NE
Metwally
A A
AA
Ebeid
F A
FA
D000818:Animals; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000097:blood*; D005260:Female; D008297:Male; D051379:Mice; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000008:administration & dosage / Q000494:pharmacology*; D011223:Praziquantel / Q000008:administration & dosage / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood*; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000097:blood / Q000276:immunology / Q000473:pathology*; D012556:Schistosomicides / Q000494:pharmacology; D013739:Testosterone / Q000097:blood*
D009600:Nitroquinolines; D012556:Schistosomicides; D010073:Oxamniquine; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011223:Praziquantel