Genetic restriction of protective immunity to Plasmodium yoelii sporozoites.
Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8+ T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.
Weiss
W R
WR
Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814.
Good
M F
MF
Hollingdale
M R
MR
Miller
L H
LH
Berzofsky
J A
JA
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D007116:Immunization, Passive; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D010967:Plasmodium yoelii / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000913:Antibodies, Protozoan