title: Cellular and viral ligands that interact with the EGF receptor.
abstract: The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The structural and functional properties that are characteristic of the ligand family provide a basis for possible evolutionary relationships among the various ligands.
authors.affiliation: Oncogen, Seattle, WA 98121.
authors.forename: G J
authors.initials: GJ
authors.lastname: Todaro
authors.forename: T M
authors.initials: TM
authors.lastname: Rose
authors.forename: C E
authors.initials: CE
authors.lastname: Spooner
authors.forename: M
authors.initials: M
authors.lastname: Shoyab
authors.forename: G D
authors.initials: GD
authors.lastname: Plowman
mesh_terms: D000595:Amino Acid Sequence; D066258:Amphiregulin; D000818:Animals; D066255:EGF Family of Proteins; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000502:physiology; D066246:ErbB Receptors / Q000378:metabolism / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D008969:Molecular Sequence Data; D016211:Transforming Growth Factor alpha / Q000378:metabolism / Q000502:physiology; D014764:Viral Proteins / Q000378:metabolism
chemical_list: C587848:AREG protein, human; D066258:Amphiregulin; D066255:EGF Family of Proteins; D006023:Glycoproteins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D016211:Transforming Growth Factor alpha; D014764:Viral Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors