Antimicrobial activity of E-4441, a representative azetidine quinolone.
E-4441 is a third-generation difluoroquinolone characterized by the presence in position 7 of an azetidine ring, disubstituted in position 3 by amine and methyl groups. E-4322 is another difluoroquinolone which differs from the former in having a 3-acetidinol substitution in position 7. E-4441 shows satisfactory levels of activity, both in vitro and in vivo, its activity against G(+) aerobic bacteria and anaerobic bacteria being generally notable.
Esteve
M
M
Laboratorios Dr. Esteve S.A., Barcelona, Spain.
Moros
M
M
Coll
R
R
Xicota
M A
MA
Llovera
S
S
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015363:Quinolones
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C069877:E 4441