title: The syndrome of abnormal chromatin clumping in leucocytes: clinical and biological study of a case.
abstract: The authors report the clinical and biological findings of a case of a rare haematological malignant entity, morphologically characterised by a bizarre nuclear abnormality in granulocytes, consisting of exaggerated chromatin clumping and apparent fragmentation of the nucleus, with a loss of segmentation. They emphasize the coexistence of proliferative and dysplastic characteristics as a distinctive marker of this disorder and suggest it may represent a distinct rare morphological entity among the atypical chronic myeloid leukaemias, Ph1 and ber negative.
authors.affiliation: Dipartimenti di Medicina Interna (Sez. Clinica Medica II) e di Bioloiga Animale, Università, IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Invernizzi
authors.forename: P
authors.initials: P
authors.lastname: Custodi
authors.forename: P
authors.initials: P
authors.lastname: de Fazio
authors.forename: G
authors.initials: G
authors.lastname: Bergamaschi
authors.forename: C
authors.initials: C
authors.lastname: Fenoglio
authors.forename: G
authors.initials: G
authors.lastname: Ricevuti
authors.forename: V
authors.initials: V
authors.lastname: Rosti
authors.forename: L M
authors.initials: LM
authors.lastname: Zambelli
authors.forename: E
authors.initials: E
authors.lastname: Ascari
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure*; D003114:Colony-Forming Units Assay; D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000473:pathology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000145:classification; D009378:Neoplasms, Multiple Primary; D009504:Neutrophils / Q000502:physiology / Q000648:ultrastructure*; D009857:Oncogenes; D010212:Papilloma; D001749:Urinary Bladder Neoplasms
chemical_list: D014408:Biomarkers, Tumor; D002843:Chromatin