Using starburst dendrimers as linker molecules to radiolabel antibodies.
Starburst dendrimers, spherical polymers constructed from methyl acrylate and ethylenediamine, were successfully used to covalently couple synthetic porphyrins to antibody molecules. The dendrimers, as linker molecules, have great potential for increasing the specific activity of radiolabeled antibodies for tumor therapy and diagnosis.
Roberts
J C
JC
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
Adams
Y E
YE
Tomalia
D
D
Mercer-Smith
J A
JA
Lavallee
D K
DK
D000906:Antibodies; D002614:Chelating Agents; D055598:Chemical Phenomena; D002621:Chemistry; D003301:Copper Radioisotopes; D004591:Electrophoresis, Polyacrylamide Gel; D005029:Ethylenediamines; D000922:Immunotoxins; D007553:Isotope Labeling / Q000379:methods*; D008768:Methylmethacrylates; D015394:Molecular Structure; D011108:Polymers; D011166:Porphyrins
D000906:Antibodies; D002614:Chelating Agents; D003301:Copper Radioisotopes; D005029:Ethylenediamines; D000922:Immunotoxins; D008768:Methylmethacrylates; D011108:Polymers; D011166:Porphyrins; C062668:N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl)porphine