title: One shot of high-dose amikacin: a working hypothesis.
abstract: Recent information suggests that single, large daily dosages of amikacin are less nephrotoxic. The killing rate of amikacin for Escherichia coli and Pseudomonas aeruginosa also suggests to put emphasis on a high peak value. A decrease of 3 log10 CFU/ml was observed for E. coli and P. aeruginosa at 64 and 128 micrograms/ml in 20 min. In comparison, the killing rate of piperacillin was dose-independent and about 6 h were required for a reduction of 10(3) CFU/ml of P. aeruginosa. In theory, the way to proceed in the future would possibly be the one-shot administration of amikacin, followed by a long course of a beta-lactam antibiotic.
authors.affiliation: Department of Microbiology, Brugmann University Hospital Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Yourassowsky
authors.forename: M P
authors.initials: MP
authors.lastname: Van der Linden
authors.forename: F
authors.initials: F
authors.lastname: Crokaert
mesh_terms: D000583:Amikacin / Q000008:administration & dosage* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D010878:Piperacillin / Q000008:administration & dosage* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin; D010878:Piperacillin