Carmofur-induced organic mental disorders.
Organic mental disorder was observed in a 29-year-old female in the prognostic period after the onset of carmofur-induced leukoencephalopathy. Symptoms such as euphoria, emotional lability and puerile attitude noted in the patient were diagnosed as organic personality syndrome according to the criteria defined in the DSM-III-R. It is referred to as a frontal lobe syndrome. Brain CT revealed a periventricular low density area in the frontal white matter and moderate dilatation of the lateral ventricles especially at the bilateral anterior horns. Consequently, carmofur-induced leukoencephalopathy may uncommonly result in organic personality syndrome in the residual state. It may be attributed to the structural damage to the frontal lobe.
Suzuki
T
T
Department of Psychiatry, University of Tsukuba, Japan.
Koizumi
J
J
Uchida
K
K
Shiraishi
H
H
Hori
M
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000328:Adult; D000970:Antineoplastic Agents; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D005500:Follow-Up Studies; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009483:Neuropsychological Tests; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; C017367:carmofur; D005472:Fluorouracil