title: [Double-blind controlled comparison of placebo and paracetamol in patients with G-6-PD deficiency].
abstract: In this study are reported 17 patients with G-6-PD deficiency. These subjects have been studied with double-blind trial between placebo and Paracetamol, looking for the possible hemolysis induced from drug in these children with G-6-PD deficiency. Hemolysis had been valued by various hematological parameters (Hb, erythrocyte count, reticulocytosis, bilirubinemia, haptoglobin, hemopexin, and survival of erythrocytes marked with Cr). The results (8 cases with placebo and 9 cases with paracetamol) demonstrate that paracetamol have not induced hemolysis in these G-6-PD deficient subjects.
authors.affiliation: 1 Clinica Pediatrica Istituto G. Gaslini, Università di Genova, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Cottafava
authors.forename: S
authors.initials: S
authors.lastname: Nieri
authors.forename: G
authors.initials: G
authors.lastname: Franzone
authors.forename: M
authors.initials: M
authors.lastname: Sanguinetti
authors.forename: L
authors.initials: L
authors.lastname: Bertolazzi
authors.forename: G
authors.initials: G
authors.lastname: Ravera
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000150:complications*; D006403:Hematologic Tests; D006801:Humans; D010919:Placebos
chemical_list: D010919:Placebos; D000082:Acetaminophen
vernacular_title: Confronto in doppio cieco controllato tra placebo e paracetamolo in soggetti carenti di G-6-PD.