The effects of anti-CD4 and anti-CD8 antibody treatment on placental growth and function in allogeneic and syngeneic murine pregnancy.
During pregnancy, maternal immune recognition of paternal alloantigens has been shown to result in an increased influx of maternal T cells into the spleen, draining lymph nodes and decidua. In previous studies we have shown that polyclonal or monoclonal anti-T cell antibody treatment of allogeneically pregnant mice results in decreased placental proliferation and phagocytosis in vivo. In the present study we compare the effect of such antibody treatment during allogeneic and syngeneic pregnancy. We show that monoclonal anti-CD8 treatment of both types of pregnant females reduces placental proliferation and phagocytosis. Anti-CD4 antibody treatment, on the other hand, only affects placental proliferation, indicating that there is a complex network of immune interactions affecting placental growth and function.
Athanassakis
I
I
Department of Immunology, University of Alberta, Edmonton, Canada.
Chaouat
G
G
Wegmann
T G
TG
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D000961:Antilymphocyte Serum; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens; D005260:Female; D008212:Lymphocyte Depletion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010587:Phagocytosis; D010920:Placenta / Q000276:immunology*; D010929:Placentation; D011247:Pregnancy; D013601:T-Lymphocytes / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000961:Antilymphocyte Serum; D015704:CD4 Antigens; D016827:CD8 Antigens