title: Anticandidal properties of N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid oligopeptides.
abstract: Tri-, tetra-, and pentapeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inactivator of glucosamine 6-phosphate synthase of fungal origin (a key enzyme in the biosynthesis of macromolecular components of the fungal cell wall) have been synthesized and investigated as anticandidal agents. Structure-activity relationships of a series of peptides revealed that tripeptides were generally more active than the other peptides examined. In this study, the lysyl peptide, Lys-Nva-FMDP has been found to be the most active compound in the series.
authors.affiliation: Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Andruszkiewicz
authors.forename: S
authors.initials: S
authors.lastname: Milewski
authors.forename: T
authors.initials: T
authors.lastname: Zieniawa
authors.forename: E
authors.initials: E
authors.lastname: Borowski
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D000935:Antifungal Agents; D002176:Candida albicans / Q000187:drug effects*; D005650:Fumarates / Q000138:chemical synthesis / Q000494:pharmacology*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D000637:Transaminases / Q000037:antagonists & inhibitors*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D005650:Fumarates; D009842:Oligopeptides; D015091:beta-Alanine; C056276:N(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid; D000637:Transaminases; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D000409:Alanine