Follicle-stimulating hormone stimulates inhibin in the serum of male monkeys (Macaca mulatta).
Three adult rhesus monkeys were injected intramuscularly with human FSH at doses of 2, 10 or 25 IU/kg in a cross-over design with 3-week intervals between injections. On each occasion a fourth animal received saline only as control. Serum levels of exogenous FSH were monitored by a fluoroimmunoassay specific for human FSH. Serum inhibin was measured by a heterologous radioimmunoassay. Each FSH injection was followed by a rise in serum inhibin in a dose-dependent manner. The half-life of human FSH in rhesus monkeys ranged from 25.1 to 32.9 h with no significant differences between doses. The rise of inhibin occurred with a lag time of 53.3 to 61.9 h after injection of FSH, independent of the dose administered. These findings support the concept that inhibin secretion in male primates is stimulated by FSH.
Fingscheidt
U
U
Institute of Reproductive Medicine of the University, Münster, FRG.
Weinbauer
G F
GF
Khan
S A
SA
Nieschlag
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000493:pharmacokinetics / Q000494:pharmacology*; D007265:Inhibins / Q000097:blood*; D008253:Macaca mulatta; D008297:Male; D008657:Metabolic Clearance Rate; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007265:Inhibins; D005640:Follicle Stimulating Hormone