Phosphate and pepsin adsorptions by a new boehmite compound and aluminum hydroxide.
A new microcrystalline compound of aluminum oxide hydroxide (tentatively named PT-A) was synthesized in the hope of providing a better phosphate adsorbent for future clinical use than the currently marketed aluminum hydroxide gels (ALG). An X-ray diffraction study demonstrated a boehmite structure in PT-A but an amorphous structure in ALG. PT-A was more stable in pH change than ALG; in elution tests in artificial gastric and intestinal solutions, aluminum ion eluted from PT-A was maximally 10% of the amount from ALG at pH 1.2; and was undetectable at pH 6.8, at which point ALG still showed some aluminum elution. Phosphate-adsorbing efficacy of PT-A and ALG in vitro was about the same at pH 1.2; however, it was four times greater in PT-A than in ALG at pH 6.8, indicating that PT-A will be effective in the intestine. PT-A also adsorbed pepsin but the amount was at most the same or much less than that adsorbed by ALG, which depended on pH in solution.
Nishida
M
M
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Yoshimura
Y
Y
Kawada
J
J
Ookubo
A
A
Kagawa
T
T
Ikawa
A
A
Hashimura
Y
Y
Suzuki
T
T
D000327:Adsorption; D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000627:therapeutic use; D000537:Aluminum Oxide; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D010434:Pepsin A / Q000302:isolation & purification*; D010710:Phosphates / Q000097:blood / Q000302:isolation & purification*
D005782:Gels; D010710:Phosphates; D000536:Aluminum Hydroxide; C069471:aluminum oxide hydroxide; D010434:Pepsin A; D000537:Aluminum Oxide