title: Acquired haemolytic anaemia due to isohaemagglutinins of donor origin following ABO-minor-incompatible kidney transplantation.
abstract: Of 1041 renal allograft transplantations performed in our centre, 142 (13.6%) were carried out with ABO-minor-incompatible kidneys. Anti-recipient ABO antibodies were found in two of 34 patients treated with cyclosporin. These two cases of severe but self-limited haemolysis due to anti-A1 and anti-B, respectively, are reported in detail. Among 108 azathioprine-treated patients no evidence of the disorder was found. The condition should be suspected in any recipient with an unexpected reduction in haematrocrit or other signs of haemolysis after ABO-minor-incompatible organ transplantation.
authors.affiliation: Department of Clinical Immunology, University Hospital, Aarhus, Denmark.
authors.forename: J V
authors.initials: JV
authors.lastname: Povlsen
authors.forename: A
authors.initials: A
authors.lastname: Rasmussen
authors.forename: H E
authors.initials: HE
authors.lastname: Hansen
authors.forename: O
authors.initials: O
authors.lastname: Fjeldborg
authors.forename: F
authors.initials: F
authors.lastname: Kissmeyer-Nielsen
authors.forename: M
authors.initials: M
authors.lastname: Madsen
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
chemical_list: D000017:ABO Blood-Group System; D003524:Cyclosporins; D006388:Hemagglutinins; D001379:Azathioprine