[The oxidative metabolic indices of phagocytizing and immunocompetent cells in patients with pulmonary tuberculosis].
Overall 94 patients with different patterns of pulmonary tuberculosis were examined for glutathione peroxidase (GP), glutathione reductase, glucose 6-phosphate dehydrogenase (G 6-PDH) and superoxide dismutase activity in neutrophils and lymphocytes. Chemiluminescence was used to study the capacity of neutrophils to generate free oxygen forms. Neutrophils showed functional deficiency of GP and G 6-PDH. The decrease of the oxygen-producing capacity of neutrophils, unbalance of glutathione-conjugated enzymes in lymphocytes were revealed either. The role of the alterations enumerated in the reduction of function of phagocytizing and immunocompetent cells in patients with pulmonary tuberculosis is discussed.
Muminov
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TA
D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D002469:Cell Separation; D005260:Female; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D010084:Oxidation-Reduction; D010587:Phagocytosis / Q000502:physiology*; D014397:Tuberculosis, Pulmonary / Q000201:enzymology*
D000975:Antioxidants
Pokazateli okislitel'nogo metabolizma fagotsitiruiushchikh i immunokomponentnykh kletok u bol'nykh tuberkulezom legkikh.