Effect of pirazolac on prostanoid synthesis by human gastric mucosa in vitro.
Pirazolac concentration-relatedly inhibited the accumulation of prostanoids in incubates of human gastric mucosa, but this inhibition was less than that by indomethacin and other commonly used non-steroidal anti-inflammatory drugs. This difference may explain the claim that pirazolac is less damaging to the stomach.
Tavares
I A
IA
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, UK.
Bennett
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008861:Microsomes / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*; D011720:Pyrazoles / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D011458:Prostaglandins E; D011720:Pyrazoles; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C046317:pirazolac; D007213:Indomethacin