Pharmaceutical application of biomedical polymers. XXIX. Preliminary study on film dosage form prepared from chitosan for oral drug delivery.
The potential of chitosan films containing diazepam as an oral drug delivery was investigated in rabbits. The results indicated that a film composed of a 1:0.5 drug-chitosan mixture might be an effective dosage form that is equivalent to the commercial tablet dosage forms. The ability of chitosan to form films may permit its use in the formulation of film dosage forms, as an alternative to pharmaceutical tablets.
Miyazaki
S
S
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
Yamaguchi
H
H
Takada
M
M
Hou
W M
WM
Takeichi
Y
Y
Yasubuchi
H
H
D000818:Animals; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan; D003692:Delayed-Action Preparations; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D011817:Rabbits
D003692:Delayed-Action Preparations; D002686:Chitin; D048271:Chitosan; D003975:Diazepam