[The effect of emotional stress on the hormonal status indices, the level of cyclic nucleotides and the content of beta 2-microglobulin in the blood and thymic tissue during the use of a synthetic analog of thyroliberin].
After experiencing a conflict situation once or daily for 5 days, rats were divided into a group resistant to stress and a group predisposed to stress according to the post-stress involution of the thymus. Changes in biochemical values were revealed in emotional stress. Significant drop in the blood insulin level, a high cAMP/cGMP ratio level, and reduction of the beta 2-microglobulin level and the level of circulating immune complexes were found. The preparation PR-546 caused an increase of the insulin level in intact and experimental rats, which, however, did not lead to diminution of the stress reaction.
Petrova
T V
TV
Vasin
M V
MV
Koroleva
L V
LV
Semenova
L A
LA
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood; D003220:Conflict, Psychological; D005260:Female; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D009712:Nucleotides, Cyclic / Q000097:blood*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D001613:beta 2-Microglobulin / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D007328:Insulin; D009712:Nucleotides, Cyclic; D001613:beta 2-Microglobulin; C060662:PR 546; D013973:Thyrotropin-Releasing Hormone; D006854:Hydrocortisone
Vliianie émotsional'nogo stressa na nekotorye pokazateli gormonal'nogo statusa, uroven' tsiklicheskikh nukleotidov i soderzhanie beta 2-mikroglobulina v krovi i tkani timusa pri primenenii sinteticheskogo analoga tiroliberina.