Hormonal and renal responses to arterial chemoreceptor stimulation by almitrine in healthy and normotensive men.
Healthy and normotensive men (n = 11) were hospitalized and kept under controlled fluid and sodium intake (120 mequ/d) for 5 days. Their systemic arterial blood pressures as well as heart and breathing rates were measured, and venous blood and urine samples were collected at intervals of 1-4 h. Diuresis was induced by scheduled drinking of tea (150 ml/h). Electrolytes, osmolality, and creatinine were determined in both plasma and urine samples. Aldosterone, cortisol, and vasopressin concentrations were measured only in the plasma. On the 2nd and 3rd day of the experiments the participants received orally either a placebo-pill or 100 mg almitrine bismesylate (Vectarion). Each subject was tested in a placebo- and an almitrine experiment. The subjects responded to the almitrine treatment with a suppression of the plasma aldosterone content, a transient rise of glomerular filtration rate, a natriuresis and an increase of renal concentrating ability. In the placebo-experiments, only the transient rise of filtration rate was significant. The data indicate that almitrine, by stimulating the peripheral arterial chemoreceptors, suppresses plasma aldosterone and inhibits renal proximal sodium reabsorption by so far unknown mechanisms. They also suggest that oral and intravenous almitrine administrations, respectively, might differently affect renal hemodynamics and excretory function.
Wiersbitzky
M
M
Clinic of Internal Medicine, Ernst Moritz Arndt University, Greifswald.
Landgraf
R
R
Gruska
S
S
Oppermann
H
H
Schuster
R
R
Balke
F
F
Wedler
B
B
Honig
A
A
D000328:Adult; D000450:Aldosterone / Q000097:blood; D015765:Almitrine / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D002628:Chemoreceptor Cells / Q000187:drug effects*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005919:Glomerular Filtration Rate; D006339:Heart Rate; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male
D006728:Hormones; D001127:Arginine Vasopressin; D000450:Aldosterone; D015765:Almitrine; D003404:Creatinine; D006854:Hydrocortisone