title: MR imaging of optic nerve lesions: value of gadopentetate dimeglumine and fat-suppression technique.
abstract: Eleven patients with known or suspected optic nerve lesions and eight normal subjects were examined with spin-echo technique at 1.5 T with unenhanced T1-weighted imaging, IV gadopentetate-dimeglumine-enhanced T1-weighted imaging, and enhanced T1-weighted imaging with fat suppression. Two pathologically proved and four presumed optic nerve meningiomas demonstrated significant enhancement and were best seen with the fat-suppression technique. None of the three presumed optic nerve gliomas nor the optic nerves of normal subjects demonstrated qualitative enhancement. We conclude that the use of a fat-suppression technique with gadopentetate dimeglumine enhancement improves delineation of enhancing optic nerve lesions. This technique should be useful for evaluating other anatomic regions where enhancing tissue marginates fat.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
authors.forename: L E
authors.initials: LE
authors.lastname: Hendrix
authors.forename: J B
authors.initials: JB
authors.lastname: Kneeland
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
authors.forename: D L
authors.initials: DL
authors.lastname: Daniels
authors.forename: J
authors.initials: J
authors.lastname: Szumowski
authors.forename: A L
authors.initials: AL
authors.lastname: Williams
authors.forename: L P
authors.initials: LP
authors.lastname: Mark
authors.forename: L F
authors.initials: LF
authors.lastname: Czervionke
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D004338:Drug Combinations; D005682:Gadolinium; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013012:Sorbitol / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D013012:Sorbitol; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA