The mouse spleen white pulp response to continuous hypoxia. A digital image processing analysis.
Ninety days old male mice of the CFW strain, placed under standard conditions for studies of periodicity, showed a 24 hours variation pattern in the spleen white pulp surface, in cross sections. This pattern was modified by hypoxia during the first 18 hours of continuous treatment. Since this time onwards a new steady state was reached, although the spleen of hypoxic animals was always smaller than in the controls. As the modifications were measured in pixel counts -a magnitude which can be easily transformed into square micrometers- they can be attributed to a real size variation and not to an apparent growth and decay due to environmental vasoactive phenomena.
Nessi de Aviñón
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Instituto de Biología Celular, Facultad de Medicina, UBA, Buenos Aires, Argentina.
Bengtsson
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D000818:Animals; D001794:Blood Pressure; D002940:Circadian Rhythm; D006411:Hematopoiesis, Extramedullary; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D013154:Spleen / Q000473:pathology / Q000503:physiopathology*