title: Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
abstract: Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.
authors.affiliation: Department of Medicine, University of California, San Francisco 94143.
authors.forename: C A
authors.initials: CA
authors.lastname: Landis
authors.forename: G
authors.initials: G
authors.lastname: Harsh
authors.forename: J
authors.initials: J
authors.lastname: Lyons
authors.forename: R L
authors.initials: RL
authors.lastname: Davis
authors.forename: F
authors.initials: F
authors.lastname: McCormick
authors.forename: H R
authors.initials: HR
authors.lastname: Bourne
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D000236:Adenoma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005947:Glucose; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006966:Hyperprolactinemia; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010911:Pituitary Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology
chemical_list: D013006:Growth Hormone; D019204:GTP-Binding Proteins; D005947:Glucose