[The immunological implications of breast cancer: the physiopathological aspects and possible therapeutic strategies in our experience].
The authors, after a short review on the physiopathological patterns which regulate the function of the immunological system in patients with neoplastic disease, report their clinical prospect study, performed on a population of 71 patients affected by breast cancer. The study has the aim to demonstrate the advantage of a complete immunological monitoring, and the efficacy of a prophylactic and therapeutic treatment with thymic hormones. Results of the study can be summarized as follow: 1) very low rate of septic complications. 2) Better results as to blood cells impairement in the group submitted to both chemo- and immunotherapy. 3) In the same group, the performance status (Karnofsky index) remained above 80% in most of cases. It is underlined in this study, the hypothesis of the prognostic value pertaining to the indexes of functionality of the immune system. Authors have indeed pointed out that early metastatic spread has been observed in the two patients, treated in 1st stage with surgery and immunotherapy, but not responding with improvement of biological data. This topic has to be developed in further studies, with the aim of changing and increasing the criteria for the staging of tumors, as the authors suggest.
Trerè
M
M
I Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.
Ciliberti
M
M
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D015166:Monitoring, Immunologic; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D013951:Thymus Hormones / Q000627:therapeutic use
D013951:Thymus Hormones
Implicazioni immunologiche nel ca. della mammella: aspetti fisiopatologici e possibili strategie terapeutiche, nella nostra esperienza.