[Autoimmune hemolytic anemia due to anti-e autoantibody of IgM class-report of a case].
A 83-year-old woman, complaining of jaundice and anemia, was diagnosed as autoimmune hemolytic anemia (AIHA) with bilirubin gall stones. Her red blood cell (RBC) group was A, Rh (D) +, but the details were indefinite due to transfusions previously repeated, while anti-C3d serum reacted positively in the direct antiglobulin test. Her serum reacted with RBC other than R2R2 in the albumin (37 degrees C) method and in the bromelin method, the reaction turning out negative after the pretreatment with 2ME. These findings indicated the autoantibody was anti-e of IgM class, which had been so far rarely reported in Japan.
Okubo
S
S
Blood Transfusion Unit of Kansai Medical University, Osaka, Japan.
Ishida
T
T
Yasunaga
K
K
D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies / Q000032:analysis*; D015933:Complement C3d / Q000032:analysis; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007075:Immunoglobulin M; D012204:Rh-Hr Blood-Group System; D015933:Complement C3d