[The cytopathic and cytogenetic sequelae of chronic inhalational exposure to formaldehyde on female germ cells and bone marrow cells in rats].
A study was made of cytopathological and cytogenetic effects of formaldehyde chronic inhalation, in doses 0.5 and 1.5 mg/m3, on the female rat's germ and marrow cells. The harmful effect of formaldehyde on germ cells (according to the patterns of early embryogenesis) is noted under the dose 1.5 mg/m3 only, while the reliable clastogenic and cytogenetic effects on the marrow cells were revealed even in the dose 0.5 mg/m3. It is concluded that the differences between effects of small doses of formaldehyde on different cell systems were evidently caused by the specific cell dynamics of these systems.
Kitaeva
L V
LV
Kitaev
E M
EM
Pimenova
M N
MN
D000280:Administration, Inhalation; D000782:Aneuploidy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D005557:Formaldehyde / Q000008:administration & dosage / Q000633:toxicity*; D008677:Metaphase / Q000187:drug effects; D010063:Ovum / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005557:Formaldehyde
Tsitopaticheskie i tsitogeneticheskie posledstviia khronicheskogo ingaliatsionnogo vozdeĭstviia formal'degida na zhenskie polovye kletki kostnogo mozga krys.