title: Pharmacokinetics of neomycin in sheep after intravenous, intramuscular, subcutaneous and intratracheal administration.
abstract: The pharmacokinetics and bioavailability of neomycin in sheep were investigated following intravenous, intramuscular, subcutaneous and intratracheal administration of 10 mg/kg. A rapid distribution phase (t 1/2 alpha, 3.16 min) was followed by a slower elimination phase (t1/2 beta, 1.98 h). The apparent volume of distribution was 304.69 ml/kg. Absorption half-lives were 18.62, 21.22 and 40.83 min and elimination half-lives 2.68, 2.82 and 2.55 h after IM, SC and IT administration, respectively. Bioavailabilities between 0.74 and 0.85 were obtained for the three routes of administration. Based on the bioavailability and disposition kinetics of neomycin, a twice daily IM dosage regimen should both be practical and adequate to maintain plasma neomycin concentrations within the pharmacologically active but nontoxic range.
authors.affiliation: Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Argentina.
authors.forename: J O
authors.initials: JO
authors.lastname: Errecalde
authors.forename: C E
authors.initials: CE
authors.lastname: Lanusse
authors.forename: M F
authors.initials: MF
authors.lastname: Landoni
mesh_terms: D000818:Animals; D001682:Biological Availability; D005260:Female; D007267:Injections / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D009355:Neomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012756:Sheep / Q000378:metabolism*
chemical_list: D009355:Neomycin