title: c-fos and c-myc expression in human endothelial cells as a function of different culture conditions.
abstract: Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Lampugnani
authors.forename: N
authors.initials: N
authors.lastname: Polentarutti
authors.forename: M
authors.initials: M
authors.lastname: Pedenovi
authors.forename: A
authors.initials: A
authors.lastname: Mantovani
authors.forename: E
authors.initials: E
authors.lastname: Dejana
authors.forename: F
authors.initials: F
authors.lastname: Colotta
mesh_terms: D001769:Blood; D002455:Cell Division; D002478:Cells, Cultured; D003470:Culture Media; D016228:Endothelial Growth Factors; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D015870:Gene Expression; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger / Q000235:genetics; D014471:Umbilical Veins
chemical_list: D003470:Culture Media; D016228:Endothelial Growth Factors; D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger