[Lyophilized cartilage--an antibiotic carrier].
Human lyophilized bruised costal cartilage was tested in vitro for its ability to act as a carrier medium for antibiotics. A remarkable capacity of accumulating streptomycin, gentamicin, tobramycin, vancomycin and ciprofloxacin was observed; whereas beta-lactum antibiotics and fosfomycin were released at a high rate. This release pattern was not influenced by the sterilization procedure, but rather by the size of the cartilage granula. Lyophilized cartilage--rehydrated in antibiotic-solutions--be helpful adjunct in the surgical management of osseous infections.
Puelacher
W
W
Universitätsklinik für Zahn-, Mund- und Kieferheilkunde, Innsbruck.
Allerberger
F
F
Waldhart
E
E
Semenitz
E
E
Dierich
M P
MP
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002356:Cartilage / Q000502:physiology*; D005612:Freeze Drying; D006801:Humans; D014677:Pharmaceutical Vehicles
D000900:Anti-Bacterial Agents; D014677:Pharmaceutical Vehicles
Lyophilisierter Knorpel--ein Antibiotikaträger.