title: Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.
abstract: Isoelectric focusing on agarose gel was used to separate the isoenzymes of serum galactosyltransferase (uridine diphosphogalactose: N-acetylglucosaminyl galactosyltransferase, EC 2.4.1.22) from 8 healthy women, and 11 ovarian cancer patients of whom 4 were in clinical remission. In all cases, we found 7 major peaks with isoelectric points ranging from 4.0-5.4. The most acidic peaks were preferentially elevated in the tumor-bearing patients, particularly the peak with pI 4.44.
authors.affiliation: Laboratoire de Biochimie, UFR des Sciences Pharmaceutiques, Caen, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Malas
authors.forename: E
authors.initials: E
authors.lastname: Bar
authors.forename: P
authors.initials: P
authors.lastname: Gauduchon
authors.forename: F
authors.initials: F
authors.lastname: Sichel
authors.forename: J Y
authors.initials: JY
authors.lastname: Le Talaer
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000201:enzymology*; D005260:Female; D005700:Galactosyltransferases / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing / Q000379:methods; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D005700:Galactosyltransferases