Effect of rubidium on the course of illness and the circadian rectal temperature in a 66-year-old depressive woman.
Rubidium (Rb+) has an antidepressive effect and shortens the circadian period in animals, whereas Li+, another alcalic metal, lengthens it. When we treated a depressive Li+ nonresponder with Rb+, we found an improvement of depression as well as a phase advance of the temperature rhythm in relation to the rest-activity rhythm.
Pflug
B
B
Zentrum der Psychiatrie, J.W. Goethe-Universität, Frankfurt/Main, F.R.G.
Köhler
W
W
Carella
A B
AB
Schmidt
K P
KP
Demisch
L
L
D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D012413:Rubidium / Q000627:therapeutic use*
D008094:Lithium; D012413:Rubidium