Deletion of a tripeptide sequence from the growth-factor domain of tissue-type plasminogen activator prolongs in vivo circulation.
Browne
M J
MJ
Department of Biotechnology, Smith Kline Beecham, Epsom, Surrey, United Kingdom.
Chapman
C G
CG
Dodd
I
I
Esmail
A F
AF
Robinson
J H
JH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism / Q000493:pharmacokinetics; D006168:Guinea Pigs; D008297:Male; D008657:Metabolic Clearance Rate; D008969:Molecular Sequence Data; D009154:Mutation; D010959:Tissue Plasminogen Activator / Q000235:genetics / Q000378:metabolism / Q000493:pharmacokinetics*
D006133:Growth Substances; D004247:DNA; D010959:Tissue Plasminogen Activator