title: Epileptic attack, delirium, and a Creutzfeldt-Jakob-like syndrome during mianserin treatment.
abstract: Our report concerns 2 patients who developed delirium after an epileptic attack during mianserin treatment. In both cases the EEG showed a change with periodic sharp slow complexes similar to that seen in Creutzfeldt-Jakob disease. The symptoms subsided, however, and the EEG normalized after the antidepressant was discontinued, suggesting a noxious response to mianserin. If Creutzfeldt-Jakob-like changes in the EEG occur, the possible effect of antidepressant medication should be considered.
authors.affiliation: Department of Psychiatry, Kuopio University Central Hospital, Kuopio, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Koponen
authors.forename: S
authors.initials: S
authors.lastname: Honkonen
authors.forename: J
authors.initials: J
authors.lastname: Partanen
authors.forename: P J
authors.initials: PJ
authors.lastname: Riekkinen
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000139:chemically induced*; D003693:Delirium / Q000139:chemically induced*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D008803:Mianserin