[Nitric oxide: from endogenous vasodilator to biologic mediator].
This paper review the actual knowledges about the physiological role of nitric oxide, sintetized from amino acid L-arginine. The nitric oxide sintetized in the vascular endothelium has a fundamental role in vascular tone, blood flow and arterial pressure control, acting stimulating guanylate cyclase on vascular smooth muscle. Nitric oxide could be considered the endogenous nitrovasodilator. Its action on the cardiovascular system are imitated by nitroglycerine, sodium nitroprusside and related compounds. Probably the disturbance in the synthesis or release of nitric oxide may be involved in the pathophysiology of hypertension, vasospasm and atherosclerosis. Recently has been shown that nitric oxide synthesis from L-arginine also occurs in other different cells like macrophages, central nervous system, liver, neutrophils, adrenal glands, playing different biological effects. Changes in nitric oxide synthesis or action in those systems, could be related to different pathological disorders as inflammation, atherosclerosis and cancer. The found of a substance as simple as nitric oxide, let suppose that we are in the presence of a biological mediator with a very early evolutionary origin, probably widespread in all the animal kingdom, and which represents the universal transduction system for activation of the soluble guanylate cyclase enzyme.
Berrazueta
J R
JR
Universidad de Cantabria, Hospital Nacional Marqués de Valdecilla, Santander.
López-Jaramillo
P
P
Moncada
S
S
D011464:Epoprostenol / Q000502:physiology; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology
D009569:Nitric Oxide; D011464:Epoprostenol
El óxido nítrico: de vasodilatador endógeno a mediador biológico.