Reduction of adrenochrome by rat liver and brain DT-diaphorase.
Liver and brain exhibit DT-diaphorase activity with adrenochrome as a substrate; the latter is an o-quinone derived from the autoxidation of adrenaline exhibiting neurotoxic and cardiotoxic properties. The reaction is strongly inhibited by dicoumarol, a classical inhibitor of DT-diaphorase. DT-diaphorase-reduced adrenochrome undergoes autoxidation as shown by the oxygen uptake occurring during the reaction. It is proposed that, physiologically, DT-diaphorase might exert a protective role by maintaining adrenochrome in its reduced, non-toxic form.
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Centro Studio Fisiologia Mitocondriale, University of Padova, Italy.
Rigobello
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MP
Galzigna
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D000323:Adrenochrome / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone); D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011808:Quinone Reductases / Q000378:metabolism*; D011809:Quinones / Q000378:metabolism; D051381:Rats
D011809:Quinones; D009249:NADP; D000323:Adrenochrome; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases