title: Peritoneal dialysis for acute renal failure: overfeeding resulting from dextrose absorbed during dialysis.
abstract: Peritoneal dialysis is a relatively safe and effective form of therapy for acute renal failure (ARF). As dextrose in the dialysate provides the osmotic gradient to achieve fluid removal, frequent exchanges with dialysate containing high dextrose is occasionally used to achieve negative balance in fluid overloaded patients. It has previously been shown that dextrose absorption from the peritoneal cavity is significant. Using indirect calorimetry and analyzing the dialysate effluent for its dextrose concentration, we studied the effects of high dextrose-containing dialysate in five patients with ARF. Despite minimal intake of calories, all patients had an RQ greater than 1.0 consistent with net lipogenesis resulting from dextrose absorbed from the peritoneal cavity. Four of five patients absorbed greater than 500 g of dextrose over 24 h. As overfeeding could lead to hepatic steatosis, increased CO2 production with worsening of respiratory failure, and hyperglycemia, the risks of using high dextrose-containing dialysate fluids should be weighed carefully against potential benefits. When nutritional support is indicated in such patients, contribution of dextrose calories from dialysate fluid should be taken into account.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA.
authors.forename: S
authors.initials: S
authors.lastname: Manji
authors.forename: S
authors.initials: S
authors.lastname: Shikora
authors.forename: M
authors.initials: M
authors.lastname: McMahon
authors.forename: G L
authors.initials: GL
authors.lastname: Blackburn
authors.forename: B R
authors.initials: BR
authors.lastname: Bistrian
mesh_terms: D000042:Absorption; D058186:Acute Kidney Injury / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D002245:Carbon Dioxide / Q000032:analysis; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010530:Peritoneal Dialysis; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D002245:Carbon Dioxide; D005947:Glucose