Interpretive criteria for disk diffusion susceptibility testing of mupirocin, a topical antibiotic.
Five hundred gram-positive clinical bacterial isolates were tested for susceptibility to mupirocin by broth microdilution and disk diffusion methods (5- and 10-micrograms disks). All but 1 of 330 staphylococci (including 100 oxacillin-resistant Staphylococcus aureus) were susceptible to less than or equal to 1.0 micrograms of mupirocin per ml. With a susceptible MIC breakpoint of less than or equal to 2.0 micrograms/ml, the corresponding zone diameter breakpoints were greater than or equal to 14 mm for 5-micrograms disks and greater than or equal to 16 mm for 10-micrograms disks. With either disk potency, susceptible staphylococci were effectively separated from more resistant gram-positive species such as the enterococci and gram-positive bacilli.
Fuchs
P C
PC
St. Vincent Hospital and Medical Center, Portland, Oregon 97225.
Jones
R N
RN
Barry
A L
AL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005227:Fatty Acids / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016712:Mupirocin; D012016:Reference Values
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D016712:Mupirocin