Alteration in the levels of pyrazinamide in pleural fluid following simultaneous administration of prednisoline in patients of tubercular pleural effusion.
20 Patients of tuberculous pleural effusion were administered a combination of pyrazinamide (30 mg/kg) + isoniazid (300 mg) orally for 7 consecutive days and pyrazinamide was estimated by spectrophotometric method in serum and pleural fluid. Prednisolone was added to the above regimen for next 7 consecutive days and pyrazinamide was again estimated. The level of pyrazinamide in pleural fluid was 23.4 +/- 1.2 (micrograms/ml). Following addition of prednisolone the level increased (27.6 +/- 1.3) significantly (P less than 0.001). The serum pyrazinamide level was not influenced by simultaneous administration of prednisolone. The pleural fluid/serum pyrazinamide ratio was increased from 0.465 to 0.542 by the addition of prednisolone to therapeutic regimen.
Wagay
A R
AR
Department of Pharmacology, J.N. Medical College, A.M.U., Aligarh.
Singhal
K C
KC
Bhargava
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000378:metabolism*; D010996:Pleural Effusion / Q000209:etiology / Q000378:metabolism*; D011239:Prednisolone / Q000494:pharmacology*; D011718:Pyrazinamide / Q000097:blood / Q000493:pharmacokinetics*; D014376:Tuberculosis / Q000150:complications / Q000378:metabolism*
D011718:Pyrazinamide; D011239:Prednisolone