Audiometry as a possible indicator of quinine plasma concentration during treatment of malaria.
The spread of chloroquine-resistant malaria has led to a resurgence of quinine in clinical use. One of the well-known side effects of quinine, reversible hearing loss, is closely related to the plasma concentration. We suggest that this hearing effect could be used as an aid in therapy control when quinine drug assay is not available.
Karlsson
K K
KK
Department of Audiology, Huddinge University Hospital, Sweden.
Hellgren
U
U
Alván
G
G
Rombo
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001301:Audiometry, Pure-Tone; D006312:Hearing Loss, Bilateral / Q000139:chemically induced; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D010963:Plasmodium falciparum; D011803:Quinine / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use
D011803:Quinine