title: Non-functional malignant paraganglioma of the stomach.
abstract: We report the second case of a malignant paraganglioma of the stomach in a 56-year-old female patient. However, our case is the first investigated by immunohistochemistry and electron-microscopy. The tumour was characterized immunohistochemically by the presence of neurofilament protein, glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, chromogranin A, ACTH, leu-enkephalin and vasoactive intestinal polypeptide, and ultrastructurally by demonstration of neurosecretory granules and paranuclear intermediate filament whorls. Despite massive metastatic spread in the abdominal cavity, the patient is still alive 4 years after initial diagnosis.
authors.affiliation: Institute of Pathology, University of Graz Medical School, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Beham
authors.forename: P
authors.initials: P
authors.lastname: Steindorfer
authors.forename: L
authors.initials: L
authors.lastname: Auböck
authors.forename: F
authors.initials: F
authors.lastname: Waltner
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D010235:Paraganglioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed