title: 1-Deamino-8-D-arginine vasopressin in the treatment of non-haemophilic patients with acquired factor VIII inhibitor.
abstract: 1-Deamino-8-D-arginine vasopressin (DDAVP) was administered to 3 patients with spontaneous factor VIII inhibitors. In 2 patients with baseline factor VIII levels above 1%, a marked increase of factor VIII activity after DDAVP infusion could be observed. No rise of factor VIII activity after DDAVP was seen in the 3rd patient with a baseline factor VIII level of less than 1%. Daily infusion of DDAVP resulted in a reduction of the efficacy, but the full effect could be retained when DDAVP was given at 48-hour intervals. The effect of DDAVP infusion on factor VIII levels in the 2 responding patients was superior to the treatment with 30 U/kg factor VIII concentrate and approximately equivalent to infusion of 45 U/kg factor VIII concentrate. DDAVP may be a useful and less expensive treatment for patients with acquired factor VIII inhibitors and a baseline factor VIII level of more than 1%.
authors.affiliation: First Department of Medicine, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Muhm
authors.forename: N
authors.initials: N
authors.lastname: Grois
authors.forename: P
authors.initials: P
authors.lastname: Kier
authors.forename: A
authors.initials: A
authors.lastname: Stümpflen
authors.forename: P
authors.initials: P
authors.lastname: Kyrle
authors.forename: I
authors.initials: I
authors.lastname: Pabinger
authors.forename: P
authors.initials: P
authors.lastname: Bettelheim
authors.forename: W
authors.initials: W
authors.lastname: Hinterberger
authors.forename: K
authors.initials: K
authors.lastname: Lechner
mesh_terms: D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy*; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D005169:Factor VIII / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D006801:Humans; D008297:Male
chemical_list: D005169:Factor VIII; D003894:Deamino Arginine Vasopressin