title: Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers.
abstract: The pharmacokinetics of dimetindene (dimethindene maleate, Fenistil, CAS 3614-69-5) were studied after its intravenous and oral administration to 8 healthy male volunteers. Serum concentrations were measured for 48 h using an enzyme-linked immunosorbent assay. Pharmacokinetic parameters (AUC, t1/2, CLs, Vd and F) were calculated using the clearance approach.
authors.affiliation: Clinical Pharmacology, Zyma S.A., Nyon, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Arnera
authors.forename: M
authors.initials: M
authors.lastname: Wermeille
authors.forename: M
authors.initials: M
authors.lastname: Wellman
authors.forename: J B
authors.initials: JB
authors.lastname: Llull
authors.forename: M A
authors.initials: MA
authors.lastname: Althaus
authors.forename: L P
authors.initials: LP
authors.lastname: Balant
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002849:Chromatography, Gas; D004115:Dimethindene / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004797:Enzyme-Linked Immunosorbent Assay; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
chemical_list: D004115:Dimethindene