title: Evidence that Cache Valley virus induces congenital malformations in sheep.
abstract: An outbreak of congenital abnormalities occurred in sheep at San Angelo, Texas, between December 1986 and February 1987. Of 360 lambs born, 19.2% had arthrogryposis or other musculo-skeletal problems and hydranencephaly (AGH), and the total neonatal loss was 25.6%. In 1987, all ewes that were tested with AGH lambs had antibody to Cache Valley virus (CVV), whereas 62% of the ewes with normal lambs had CVV-specific antibody. Pre-colostral serum samples from AGH lambs had neutralizing antibody to CVV. An increase in prevalence of CVV-specific antibody, from 5% during the spring of 1986 to 63.4% during the winter of 1987, occurred during a time that included the gestation of these affected lambs, as well as a period of increased rainfall. The isolation of a CVV-related strain from a sentinel sheep in October 1987 confirmed the continued presence of this virus in the pasture where this outbreak occurred and provided a recent field strain for future studies.
authors.affiliation: Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
authors.forename: S I
authors.initials: SI
authors.lastname: Chung
authors.forename: C W
authors.initials: CW
authors.lastname: Livingston
authors.forename: J F
authors.initials: JF
authors.lastname: Edwards
authors.forename: R W
authors.initials: RW
authors.lastname: Crandell
authors.forename: R E
authors.initials: RE
authors.lastname: Shope
authors.forename: M J
authors.initials: MJ
authors.lastname: Shelton
authors.forename: E W
authors.initials: EW
authors.lastname: Collisson
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D001176:Arthrogryposis / Q000209:etiology / Q000662:veterinary; D002042:Bunyamwera virus / Q000276:immunology / Q000302:isolation & purification; D002044:Bunyaviridae Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000662:veterinary; D006832:Hydranencephaly / Q000209:etiology / Q000662:veterinary; D008297:Male; D009139:Musculoskeletal Abnormalities; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000662:veterinary*; D015995:Prevalence; D012756:Sheep; D012757:Sheep Diseases / Q000151:congenital* / Q000453:epidemiology / Q000209:etiology; D013781:Texas / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral