Dose-related effects of selective 5-HT2 receptor antagonists on slow wave sleep in humans.
The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169.369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the data cannot exclude involvement of the closely related 5-HT1c receptor in this effect.
Sharpley
A L
AL
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
Solomon
R A
RA
Fernando
A I
AI
da Roza Davis
J M
JM
Cowen
P J
PJ
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000502:physiology; D016713:Ritanserin; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
D010880:Piperidines; D011804:Quinolines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D016713:Ritanserin; C054363:2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline