The validity of animal models in the search for drugs for the aging brain.
The search for drugs of use in the treatment of age-associated memory impairment, multi-infarct dementia, and Alzheimer's disease is frustrated by the expense or inadequacy of animal models of these conditions. We hope that this critical review of existing models will stimulate the use and proper interpretation of the best of these models, and encourage thinking in devising new models.
Pepeu
G
G
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Pepeu
I M
IM
Casamenti
F
F
D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans