Hexachlorophene toxicosis in a litter of Doberman pinschers.
A litter of 5-week-old Doberman Pinschers with pustular dermatitis was treated dermally with a hexachlorophene-containing emulsion. Shortly after a second treatment, all of the puppies developed neurologic signs consisting of muscle tremors, ataxia, and apparent muscle weakness. The clinical history and signs, histologic lesions within the central nervous system, and measurement of hexachlorophene in liver and kidney tissue confirmed a diagnosis of hexachlorophene toxicosis.
Poppenga
R H
RH
Animal Health Diagnostic Laboratory, Michigan State University, College of Veterinary Medicine, East Lansing 48824.
Trapp
A L
AL
Braselton
W E
WE
Louden
C G
CG
Gumbs
J M
JM
Dalley
J B
JB
D000818:Animals; D000831:Animals, Newborn; D002490:Central Nervous System / Q000473:pathology; D004283:Dog Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004285:Dogs; D006582:Hexachlorophene / Q000032:analysis / Q000506:poisoning*; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D011041:Poisoning / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary
D006582:Hexachlorophene