Pharmacokinetic behavior of ciprofloxacin both in native cardiac and porcine valves treated in glutaraldehyde.
When judging a probable therapeutic success for antibiotic management of bioprosthetic endocarditis, sufficient drug levels in heterologous valve tissues play a very important role. The pharmacokinetic behavior of ciprofloxacin was investigated in native and porcine valvular tissues and compared with plasma levels during a 90- to 120-min period of surgery. Analysis was carried out by HPLC using excised valvular tissues (Hancock T 505). In all, 15-20 patients were investigated in each group. The antibiotics were administered intravenously or per os. Tissue concentrations after onset of the procedures showed ciprofloxacin plasma concentrations of 2.09-0.47 micrograms g in the native and 3.98-1.99 micrograms/g in the heterologous valvular tissues.
Kalmár
P
P
Department of Cardiovascular and Experimental Surgery, University of Hamburg, FRG.
Goecke
N
N
Kraas
E
E
Menzel
T
T
D000328:Adult; D000368:Aged; D000447:Aldehydes; D000818:Animals; D001705:Bioprosthesis; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005260:Female; D005976:Glutaral; D006350:Heart Valve Prosthesis; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010210:Papillary Muscles / Q000378:metabolism; D013552:Swine
D000447:Aldehydes; D002939:Ciprofloxacin; D005976:Glutaral