Effect of low mole fraction of trehalose dicorynomycolate from Corynebacterium diphtheriae on water permeability and electrical capacitance of lipid bilayer membranes.
The effect of incorporation of different proportions of trehalose dicorynomycolates (TDC) into lecithin bilayer membranes was studied. It was found that TDC, induces a 14% decrease of water osmotic permeability (42.6 +/- 3.9 to 36.8 +/- 2.7 microns/s) at 1.6 mole%, suggesting that this substance leads to an increase of the degree of packing of the constituent lipid molecules. A condensing effect of TDC was also apparent from membrane electrical capacitance (Cm) measurement. By incorporating TDC into bilayer membranes, the value of Cm experienced a decrease of 29% at 1.6% mole fraction. This finding was taken to reflect an increase in membrane thickness, known in many examples, to be related to the condensing effect.
Imasato
H
H
Instituto de Física e Química de São Carlos da Universidade de São Paulo, Departamento de química e Física Molecular, Brazil.
Procópio
J
J
Tabak
M
M
Ioneda
T
T
D003311:Cord Factors; D003353:Corynebacterium diphtheriae; D004553:Electric Conductivity; D006017:Glycolipids; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010539:Permeability; D014867:Water / Q000493:pharmacokinetics*
D003311:Cord Factors; D006017:Glycolipids; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D014867:Water; C043399:6,6'-dicorynomycolyl trehalose