The effect of glutathion on the reaction of cis-and trans-diamminedichloroplatinum(II) with DNA.
Differential pulse polarography study was used to investigate the influence of glutathion on cis- and trans-DDP induced alterations of DNA structure. Though the applied concentration of glutathion has no effect on the reaction on DNA with cis-DDP, it greatly modifies the reaction with trans isomer. This may be an important reason for the ineffectiveness of the trans-DDP as an antitumor drug.
Oliński
R
R
Institute of Biochemistry, University of Lódz, Poland.
D000818:Animals; D002417:Cattle; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000302:isolation & purification; D005978:Glutathione / Q000494:pharmacology*; D011048:Polarography; D013950:Thymus Gland
D004247:DNA; D005978:Glutathione; D002945:Cisplatin