DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.
To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".
Blankenstein
T
T
Institut für Immunologie, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
Qin
Z H
ZH
Li
W Q
WQ
Diamantstein
T
T
D000818:Animals; D001483:Base Sequence; D015321:Gene Rearrangement; D007426:Genes, Intracisternal A-Particle; D015850:Interleukin-6 / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D010954:Plasmacytoma / Q000235:genetics*
D015850:Interleukin-6