Thromboplastin activity of blood monocytes after total hip replacement.
Thromboplastin activity of monocytes from blood of seven patients with total hip replacement was investigated. At 24 h and 48 h after surgery, thromboplastin activity was significantly increased compared to the activity before surgery. Thromboplastin activity of endotoxin-stimulated monocytes was significantly increased at 24 h after surgery. There were no significant changes in Factor V after surgery, Factor VII was significantly lowered at 24 h after surgery, while Factor VIII and fibrinogen were significantly increased at 72 h after surgery. The results indicate that monocyte thromboplastin may be a thrombogenic factor after total hip replacement surgery.
Nygaard
O P
OP
Department of Orthopaedic Surgery, University of Tromsø, Norway.
Unneberg
K
K
Reikerås
O
O
Osterud
B
B
D000368:Aged; D004731:Endotoxins / Q000494:pharmacology; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*
D004731:Endotoxins; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005340:Fibrinogen; D013925:Thromboplastin