Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels.
Mutations in the period (per) gene of Drosophila melanogaster affect both circadian and ultradian rhythms. Levels of per gene product undergo circadian oscillation, and it is now shown that there is an underlying oscillation in the level of per RNA. The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.
Hardin
P E
PE
Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254.
Hall
J C
JC
Rosbash
M
M
D000818:Animals; D002940:Circadian Rhythm; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005246:Feedback; D005786:Gene Expression Regulation; D009043:Motor Activity / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D012260:Ribonucleases
D029721:Drosophila Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; D011506:Proteins; D012333:RNA, Messenger; D012260:Ribonucleases