Regulation of human megakaryocytopoiesis.
Megakaryocytopoiesis is a complex, highly regulated cellular and biologic process which leads to the production of platelets. The proliferation of megakaryocyte (MK) progenitors is mainly regulated by interleukin-3, granulocyte-macrophage colony-stimulating factor and an as yet uncharacterized MK colony-stimulating factor. The maturation of MKs to produce platelets is essentially regulated by interleukin-6 and thrombopoietin. Optimal megakaryocytopoiesis is controlled by appropriate combinations of positive and negative influence. Megakaryocytopoietic inhibition is controlled by transforming growth factor beta, platelet factor 4 and its related proteins, interferon-alpha and -gamma.
Han
Z C
ZC
INSERM U150, Institut des Vaisseaux et du Sang, Hôpital Lariboisière, Paris, France.
Bellucci
S
S
Caen
J P
JP
D001792:Blood Platelets / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D005246:Feedback; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D006131:Growth Inhibitors / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology*
D006131:Growth Inhibitors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor