Genome instability as a consequence of DNA-repair and immune system abnormalities.
The cellular level analysis of 720 clinically persons with cytogenetic abnormalities has been performed in this study. Of them 25% showed an increased number of cells with cytogenetic abnormalities. Repeated examination of these patients allowed to "eliminate" sporadic cases of genome instability from the given group. The remaining, 30% of cases, had reliable decrease in excision repair and significant changes in immunoreactivity. At the same time a decrease of activity of DNA-repair synthesis was noticed in donors with a higher number of cells with cytogenetic aberrations.
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Tomsk Medical Institute, Department of Genetics, USSR.
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D004260:DNA Repair / Q000235:genetics*; D004912:Erythrocytes / Q000473:pathology; D006801:Humans; D007154:Immune System Diseases / Q000097:blood / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology