title: [Diverse hemostatic abnormalities in a patient with biclonal multiple myeloma].
abstract: A 58-year-old female was referred to us because of M-proteinemia and anemia. Bone marrow showed normal cellularity with 14.8% of atypical plasma cells. Serum electrophoresis on cellulose acetate membrane revealed a single M-peak (56.9%). Immunoelectrophoresis showed large M-bows against anti-IgA and anti-lambda, together with small M-bows against anti-IgG and anti-kappa of the same electrophoretic mobility. In the urine, lambda type Bence Jones protein was found. The skull X-ray showed multiple punched out lesions. APTT was 61 seconds, fibrinogen 118 mg/dl, factor VIII clotting activity 25% with normal factor VIII related antigen, and factor IX clotting activity 38%. Circulating anticoagulants were not detected. These hemostatic abnormalities were thought ascribable to the interference of clotting activities by paraproteins. On the 33rd hospital day, she suffered from intracerebral hemorrhage, which was possibly due to these hemostatic abnormalities.
authors.affiliation: Third Department of Internal Medicine, Nippon Medical School.
authors.forename: I
authors.initials: I
authors.lastname: Komiya
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K Z
authors.initials: KZ
authors.lastname: Dan
authors.forename: S
authors.initials: S
authors.lastname: Kuriya
authors.forename: T
authors.initials: T
authors.lastname: Nomura
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications*; D009194:Myeloma Proteins / Q000378:metabolism*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D009194:Myeloma Proteins