Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin.
There were no statistically significant differences in final body weight or in food intake among groups of rats fed for 7 wk various fats of animal origin (lard fat and cod liver oil) or vegetable origin (corn, soybean and canola oils); the fats were fed as 10% of the diet (by wt) and were of varied fatty acid composition. Nevertheless, the mean weights of the kidneys from cod liver oil-fed animals were significantly higher than those of all other dietary groups. Platelets of rats from the groups receiving the animal fat contained significantly lower levels of linoleic acid, 18:2(n-6) [a precursor of arachidonic acid, 20:4(n-6)], than did platelets from rats receiving the fat of vegetable origin. Although the soybean-, canola- and cod liver oil-fed animals received substantial quantities of (n-3) fatty acids [alpha-linolenic acid, 18:3(n-3); eicosapentaenoic acid, 20:5(n-3); and docosahexaenoic acid, 22:6(n-3)], only the platelets of the latter two groups contained detectable levels of these fatty acids along with their products of elongation/desaturation/retroconversion. Platelets of the cod liver oil-fed group contained significantly less arachidonic acid, a major precursor of eicosanoids, than did those from all other dietary groups. However, platelet arachidonic levels also varied markedly among the other dietary groups. Diet-induced fatty acid changes observed in platelets of various dietary groups may influence platelet responses, including secretion, aggregation and biosynthesis of eicosanoids.
Piché
L A
LA
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
Mahadevappa
V G
VG
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000032:analysis; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002849:Chromatography, Gas; D003060:Cod Liver Oil / Q000008:administration & dosage* / Q000032:analysis; D004041:Dietary Fats / Q000008:administration & dosage* / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000032:analysis; D005395:Fish Oils / Q000008:administration & dosage*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage* / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008041:Linoleic Acids; D010938:Plant Oils; D016718:Arachidonic Acid; D003060:Cod Liver Oil; D019787:Linoleic Acid