Interaction of intravenous methylprednisolone with oral cyclosporin.
The plasma cyclosporin values during 17 consecutive rejection episodes in 13 renal allograft recipients have been monitored by high-performance liquid chromatography and radioimmunoassay. In response to anti-rejection therapy with intravenous methylprednisolone, there was a significant increase of greater than 100 ng/ml on only three occasions. We suggest that elevated cyclosporin values during rejection episodes should not be dismissed as the result of steroid therapy and that the original diagnosis must be reviewed.
Ubhi
C S
CS
University Department of Surgery, St. James's University Hospital, Leeds, UK.
Woodhouse
L
L
Giles
G R
GR
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D007275:Injections, Intravenous; D016030:Kidney Transplantation; D008775:Methylprednisolone / Q000494:pharmacology*; D011863:Radioimmunoassay
D003524:Cyclosporins; D008775:Methylprednisolone