title: Insulin-like growth factor I (IGF-I) levels in follicular fluid from human preovulatory follicles: correlation with serum IGF-I levels.
abstract: Insulin-like growth factor I (IGF-I) levels were measured in both serum and fluid of preovulatory follicles (n = 156) in 43 women undergoing in vitro fertilization (IVF). The mean IGF-I level in follicular fluid (FF) was significantly lower than in serum (0.52 +/- 0.02 IU/L versus 0.66 +/- 0.23 IU/L), and FF levels were significantly correlated with individual serum IGF-I levels as well as with follicular size and FF volume but not with oocyte maturity, granulosa cell appearance, or IVF. This suggests that FF IGF-I levels cannot serve as a clinical indicator for the degree of oocyte/granulosa cell differentiation or a predictor for IVF. Serum IGF-I levels were inversely correlated with the number of human menopausal gonadotropin ampules administered during treatment, suggesting that IGF-I might enhance ovarian gonadotropic stimulation.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco 94143.
authors.forename: J
authors.initials: J
authors.lastname: Rabinovici
authors.forename: P
authors.initials: P
authors.lastname: Dandekar
authors.forename: M J
authors.initials: MJ
authors.lastname: Angle
authors.forename: S
authors.initials: S
authors.lastname: Rosenthal
authors.forename: M C
authors.initials: MC
authors.lastname: Martin
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000032:analysis* / Q000502:physiology; D005498:Follicular Phase; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000032:analysis* / Q000166:cytology; D013002:Somatomedins / Q000032:analysis*
chemical_list: D013002:Somatomedins; D004958:Estradiol; D008596:Menotropins; D007334:Insulin-Like Growth Factor I