Potentiated depression of indirectly evoked twitch tension of rat soleus muscle following arterial blood occlusion in the presence of ketamine.
The presence of ketamine, in a dose insufficient to depress the indirectly evoked twitch tension of soleus muscle, was shown to significantly potentiate the depression of the indirectly evoked twitch tension following a 10-min occlusion of the arterial blood to this muscle. Since ketamine was known to be an uncoupling agent in oxidative phosphorylation, it was possible that its uncoupling property potentiated the effect of the 10-min blood occlusion to depress the indirectly evoked twitch tension of soleus muscle.
Wong
K K
KK
Department of Pharmacology, National Yang-Ming Medical College Taipei, Taiwan, Republic of China.
D000818:Animals; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000098:blood supply*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007649:Ketamine; D010424:Pentobarbital