[Development of press-coated tablets with controlled-release effect with a base of poly-d(-)-3-hydroxybutyric acid].
A new drug delivery system with controlled-release effect based on press-coated tablets using poly-D(-)-3-hydroxybutyric acid (Poly-HB) is presented. Model investigations show that the coating of a drug containing core with an indifferent matrix consisting of Poly-HB, a channeling agent (sodium chloride, potassium nitrate or lactose) and the initial dose of the drug leads to a zero-order release kinetics. The system is applicable for oral and parenteral dosage of various drugs.
Korsatko-Wabnegg
B
B
Institut für Pharmazeutische Chemie, Karl-Franzens-Universität Graz, Osterreich.
D020155:3-Hydroxybutyric Acid; D002626:Chemistry, Pharmaceutical; D006885:Hydroxybutyrates / Q000737:chemistry*; D007700:Kinetics; D013608:Tablets, Enteric-Coated
D006885:Hydroxybutyrates; D013608:Tablets, Enteric-Coated; D020155:3-Hydroxybutyric Acid
Entwicklung von Manteltabletten mit "Controlled-Release"-Effekt auf der Basis von Poly-D(-)-3-hydroxybuttersäure.