title: Frequency of the -alpha 3.7 thalassemia deletion in the non-white Cuban population.
abstract: DNA analysis of the alpha-globin gene cluster showed that the frequency of the -alpha 3.7 deletion in the non-white cuban population is about 0.12, in agreement with a 47% admixture of the original African slaves introduced in the island. In the S-S homozygotes the frequency is slightly higher (.18), probably due to a selective advantage produced by the presence of alpha-thalassemia in sickle cell patients.
authors.affiliation: Instituto de Hematologia e Inmunologia, La Habana, Cuba.
authors.forename: G
authors.initials: G
authors.lastname: Martinez
authors.forename: R
authors.initials: R
authors.lastname: Ferreira
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
authors.forename: A
authors.initials: A
authors.lastname: Di Rienzo
authors.forename: L
authors.initials: L
authors.lastname: Felicetti
authors.forename: B
authors.initials: B
authors.lastname: Colombo
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000235:genetics; D044383:Black People / Q000235:genetics; D002872:Chromosome Deletion; D003462:Cuba; D004247:DNA / Q000032:analysis; D005787:Gene Frequency; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D005810:Multigene Family; D013789:Thalassemia / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005914:Globins; D004247:DNA