The tumor necrosis factors: cachectin and lymphotoxin.
The extensive tissue damage associated with endotoxemia and the phenomenon of tumor necrosis are both triggered by cachectin and lymphotoxin--two leukocyte products with potentially toxic effects on virtually every organ system. Understanding the role of these cytokines in the pathogenesis of inflammation may lead to effective therapy for a wide range of diseases.
Beutler
B
B
University of Texas Southwestern Medical School, Dallas.
D000818:Animals; D000855:Anorexia / Q000209:etiology; D001424:Bacterial Infections / Q000097:blood; D015870:Gene Expression; D006801:Humans; D008233:Lymphotoxin-alpha; D009369:Neoplasms / Q000097:blood; D009374:Neoplasms, Experimental / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha