title: Syntheses of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-cysteine and of some isotopically labelled (2H, 13C) analogues.
abstract: The chemical syntheses of human metabolites of S-carboxymethyl-L-cysteine (3) and S-methyl-L-cysteine (12) are described. The additional preparation of some 2H- and 13C-labelled isotopomers enabled the direct evaluation of the stabilities of 3 and 12 under physiological conditions and also facilitated the unambiguous assignments of the signals in the 13C-NMR spectra of all compounds mentioned.
authors.affiliation: Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, FRG.
authors.forename: C O
authors.initials: CO
authors.lastname: Meese
authors.forename: D
authors.initials: D
authors.lastname: Specht
authors.forename: U
authors.initials: U
authors.lastname: Hofmann
mesh_terms: D002233:Carbocysteine / Q000138:chemical synthesis* / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy
chemical_list: D002233:Carbocysteine; C008425:S-methylcysteine; D003545:Cysteine