title: Diaphragmatic fatigue is associated with decreased inositol 1,4,5-trisphosphate formation.
abstract: The ability of the rat diaphragm to produce inositol 1,4,5-trisphosphate (InsP3) in response to a maximal contractile stimulus was determine in vitro in both fatigued and nonfatigued diaphragms. InsP3 was produced during a maximal contraction of the diaphragm. After inducing fatigue, there was a significant reduction in the production of InsP3 compared with that in nonfatigued muscle. The maximal force generated by the diaphragm was also decreased after fatigue. A significant positive linear correlation was found between the force developed by the diaphragm and the amount of InsP3 liberated.
authors.affiliation: Department of Pharmacology, Louisiana State University Medical Center, Shreveport 71130.
authors.forename: J H
authors.initials: JH
authors.lastname: Zavecz
authors.forename: W M
authors.initials: WM
authors.lastname: Anderson
authors.forename: K
authors.initials: K
authors.lastname: Phillips
authors.forename: L
authors.initials: L
authors.lastname: McNatt
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D009119:Muscle Contraction; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D015544:Inositol 1,4,5-Trisphosphate