Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae).
Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.
Harada
K
K
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Matsuura
K
K
Suzuki
M
M
Watanabe
M F
MF
Oishi
S
S
Dahlem
A M
AM
Beasley
V R
VR
Carmichael
W W
WW
D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000032:analysis*; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins; D052998:Microcystins; D010456:Peptides, Cyclic / Q000032:analysis* / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D008387:Marine Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; C063855:microcystin RR; C057862:cyanoginosin LR