Cytogenetic analysis in patients with myelodysplastic syndrome.
Forty-six patients with myelodysplastic syndrome (MDS) were studied. Chromosomal abnormalities were observed in 20 of the 46 patients (43%). Abnormalities of chromosome No. 5 occurred in 6 patients (13%); four of them had a deletion of the long arm of this chromosome [del (5q)]. Four patients had monosomy 7 (8.6%), and six patients had trisomy 8 (13%). Our results suggest that chromosomal abnormalities, deletion (5q), monosomy 7 and trisomy 8, might play important roles in the pathogenesis of MDS.
Hu
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N
Cancer Institute, CAMS, Beijing.
Bian
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M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D008875:Middle Aged; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy