title: Radiosurgery of cerebral arteriovenous malformations with the dynamic stereotactic irradiation.
abstract: From December 1986 through December 1988, 33 patients with inoperable arteriovenous malformation (AVM) were treated in our center with the dynamic stereotactic radiosurgery, which uses a standard 10 MV isocentric linear accelerator. There were 18 females and 15 males with a median age of 26 years (range: 9-69) and a median follow-up time of 16 months (range: 7-32). The arteriovenous malformation volumes treated ranged from 0.2 to 42 cm3. The prescribed doses at the isocenter varied from 50 to 55 Gy and were given as a single fraction in the majority of the patients (31/33). Late complications consisting of intracranial bleeding and/or hemiparesis were observed in three patients. To date, 21 patients underwent repeat angiographic studies at 1 year post-treatment. A complete obliteration of the lesion was achieved in 38% of these patients. For the patients whose arteriovenous malformation nidus was covered by a minimum dose of 25 Gy, the total obliteration rate was 61.5% (8/13), whereas none of the patients who had received less than 25 Gy at the edge of the nidus obtained a total obliteration. Our preliminary analysis at 1 year post-radiosurgery reveals results comparable to those previously reported for other radiosurgical techniques for the same follow-up period.
authors.affiliation: Dept. of Radiation Oncology, McGill University, Montréal, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Souhami
authors.forename: A
authors.initials: A
authors.lastname: Olivier
authors.forename: E B
authors.initials: EB
authors.lastname: Podgorsak
authors.forename: M
authors.initials: M
authors.lastname: Pla
authors.forename: G B
authors.initials: GB
authors.lastname: Pike
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011882:Radiotherapy, High-Energy / Q000379:methods; D013238:Stereotaxic Techniques