title: Anticoagulation instability with life-threatening complication after dietary modification.
abstract: Anticoagulation instability due to a change in intake of vitamin K after dietary modification was observed in 2 patients on long-term oral anticoagulants. One patient developed diffuse bruises treated conservatively with fresh frozen plasma transfusion and the other had a thrombosed aortic prosthesis which required emergency operation. To prevent such complications, dietary modification especially with food rich in vitamin K should be undertaken with care in patients on long-term oral anticoagulants.
authors.affiliation: Department of Medicine, Grantham Hospital, Aberdeen, Hong Kong.
authors.forename: W H
authors.initials: WH
authors.lastname: Chow
authors.forename: T C
authors.initials: TC
authors.lastname: Chow
authors.forename: T M
authors.initials: TM
authors.lastname: Tse
authors.forename: Y T
authors.initials: YT
authors.lastname: Tai
authors.forename: W T
authors.initials: WT
authors.lastname: Lee
mesh_terms: D000328:Adult; D001021:Aortic Valve; D001777:Blood Coagulation / Q000187:drug effects*; D004032:Diet; D004347:Drug Interactions; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D014812:Vitamin K / Q000008:administration & dosage* / Q000494:pharmacology; D014813:Vitamin K Deficiency / Q000150:complications; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D014812:Vitamin K; D014859:Warfarin