Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks.
We performed filtration surgery in glaucomatous monkeys to determine if bioerodible polyanhydride disks that contained 5-fluorouridine (5-FUR) prolonged the success of the operation. First, in vitro studies demonstrated that 5-fluorouridine was released from the disks for at least 16 days in a bioactive form that inhibited fibroblast proliferation. Next, a preliminary series of six eyes suggested that using disks that contained 5-fluorouridine extended the intraocular pressure-lowering effect of filtration surgery. This finding was confirmed in eight additional eyes of four animals in which one eye received a disk with 5-fluorouridine and the other received a disk without the drug. The duration of success of the operation was significantly longer in the eyes that received polyanhydride with 5-fluorouridine (mean +/- SD, 26.0 +/- 9.2 days) than in the controls (8.5 +/- 4.0 days). The histologic findings of the experimental eyes correlated with their prolonged clinical success.
Jampel
H D
HD
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Md.
Leong
K W
KW
Dunkelburger
G R
GR
Quigley
H A
HA
D000818:Animals; D002478:Cells, Cultured; D003315:Cornea / Q000473:pathology; D003652:Decanoic Acids / Q000008:administration & dosage* / Q000633:toxicity; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects; D005402:Fistula / Q000473:pathology; D005901:Glaucoma / Q000601:surgery*; D000882:Haplorhini; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D011091:Polyesters / Q000008:administration & dosage* / Q000633:toxicity; D011183:Postoperative Complications / Q000473:pathology; D011379:Prognosis; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
D003652:Decanoic Acids; D004337:Drug Carriers; D011091:Polyesters; C001943:5-fluorouridine; C055401:decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; D014529:Uridine