Influence of tea and coffee beverages on prostacyclin synthesis by the rat aorta.
Influences of 2.5 and 5% (w/v) aqueous tea and coffee beverages administered ad lib. to rats for two weeks on PGI2 synthesis by the rat thoracic aorta in vitro were investigated using a rat platelet antiaggregatory bioassay and HPLC methods. The 2.5% beverages did not affect PGI2 synthesis; however, the 5% beverages significantly decreased PGI2 synthesis. The observed decreases were significantly abolished in presence of exogenous arachidonic acid suggesting a beverage-induced inhibition of precursor release. The ability of the beverages to inhibit PGI2 synthesis may partly contribute towards better understanding of the biochemical mechanisms underlying some of the beverages-induced actions in vivo.
el Tahir
K E
KE
Department of Pharmacology and Pharmaceutical Chemistry, College of Pharmacy, Kind Saud University, Riyadh, Kingdom of Saudi Arabia.
Hamad
E A
EA
Ageel
A M
AM
Abu Nasif
M A
MA
Gadkarim
E A
EA
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D003069:Coffee; D004326:Drinking; D011464:Epoprostenol / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013662:Tea
D003069:Coffee; D013662:Tea; D011464:Epoprostenol