title: Causative agents of acute diarrhoea in the first 3 years of life: hospital-based study.
abstract: During the 2 years of the study, 402 patients and an equal number of age- and sex-matched controls were investigated for the presence of diarrhoeal pathogens. Pathogenic organisms were recovered from 277 (68.9%) patients and 97 (24.1%) controls. In the patient group, possible bacterial pathogens were found in 210 (52.2%) cases. Enteropathogenic Escherichia coli (EPEC) was the most frequently found potential pathogen, being recovered in 132 cases (32.8%) with serotypes 026, 086, 0111 and 0124 being the most frequently identified. Other bacterial pathogens identified were enterotoxigenic E. coli (ETEC) 57 (14.2%), Shigella 13 (3.2%) and Salmonella eight (2%). Rotavirus was identified in 33 (8.2%) cases. Mixed bacterial and viral infections were also seen in 26 (6.5%) cases. In the control group, enteric pathogens were recovered from 97 (24.1%) specimens. The most common bacterial pathogen found in this group was again EPEC (40, 9.9%), with serogroups 018, 044, 0111 and 0126 being the most frequent. Giardia lamblia and Entamoeba histolytica were found in 31 (7.7%) and 10 (2.5%) controls, respectively. Rotavirus was found in 16 (4%) controls. The results of both centres where the study was performed (Karachi and Rawalpindi) were compared.
authors.affiliation: Pakistan Medical Research Council, Central Research Centre, National Institute of Health, Islamabad.
authors.forename: M
authors.initials: M
authors.lastname: Mubashir
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: R
authors.initials: R
authors.lastname: Baqai
authors.forename: J
authors.initials: J
authors.lastname: Iqbal
authors.forename: A
authors.initials: A
authors.lastname: Ghafoor
authors.forename: S
authors.initials: S
authors.lastname: Zuberi
authors.forename: M I
authors.initials: MI
authors.lastname: Burney
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology*; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007411:Intestinal Diseases, Parasitic / Q000453:epidemiology; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D014777:Virus Diseases / Q000453:epidemiology