title: Heterogeneity of rat plasma albumin and drug binding.
abstract: Rat plasma albumin fractionated by Sephadex G-75 (superfine) gel filtration from freshly prepared rat plasma was further separated into three major fractions by chromatofocusing column chromatography. All the fractionated albumins had high binding affinity for the fluorescent probe 8-anilino-1-naphthalenesulfonic acid, as the model compound for acidic drugs, and were found to be immunologically identical.
authors.affiliation: Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: T
authors.initials: T
authors.lastname: Horie
authors.forename: T
authors.initials: T
authors.lastname: Mishima
authors.forename: Y
authors.initials: Y
authors.lastname: Minamide
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Awazu
mesh_terms: D000817:Anilino Naphthalenesulfonates / Q000378:metabolism*; D000818:Animals; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D005227:Fatty Acids / Q000032:analysis; D005456:Fluorescent Dyes; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D005779:Immunodiffusion; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D013050:Spectrometry, Fluorescence
chemical_list: D000817:Anilino Naphthalenesulfonates; D005227:Fatty Acids; D005456:Fluorescent Dyes; D012709:Serum Albumin; C027132:1-anilino-8-naphthalenesulfonate