title: Heart and heart-lung transplantation at the Johns Hopkins Hospital.
abstract: Since 1983, 120 patients have undergone heart transplantation and 18 patients have had heart-lung transplants at our institution. Transplantation is limited only by donor referrals but relaxation of donor criteria has increased donor availability. Immunosuppression currently consists of a 3-drug protocol of CsA, Aza, and P. Our current 1- and 5-year survival rates for heart transplants are 85% and 66%, respectively. The 1-year survival for heart-lung transplantation is 53%. Research continues in many areas of transplantation. The development of coronary artery disease in grafted hearts remains a problem. We have found that older donor age and Cmv infection are significant predictors of developing coronary disease. Routine successful extended heart-lung preservation has been difficult to achieve. A successful technique of prolonged preservation would allow for better matching, reduced logistics, and, potentially, increased numbers of donor organs.
authors.affiliation: Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: D L
authors.initials: DL
authors.lastname: Johnson
authors.forename: W A
authors.initials: WA
authors.lastname: Baumgartner
authors.forename: B A
authors.initials: BA
authors.lastname: Reitz
mesh_terms: D000367:Age Factors; D015142:Baltimore; D005500:Follow-Up Studies; D006084:Graft Rejection; D016027:Heart Transplantation / Q000276:immunology; D016041:Heart-Lung Transplantation / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D014019:Tissue Donors; D009927:Tissue and Organ Procurement