Cumulative reduction of primary skin tumor growth in UV-irradiated mice by the combination of retinyl palmitate and canthaxanthin.
The effects of dietary supplementation with retinyl palmitate, canthaxanthin, or the combination of both, on photocarcinogenesis was determined in pigmented C3H/HeN mice. The basal diet was the American Institute of Nutrition Diet 76A, to which was added 120 IU of retinyl palmitate per g diet, 1% canthaxanthin, or the combination of both. Administration of the diets began 18 weeks before the first UVB radiation (280-320 nm) treatment and continued throughout the study. The UV source was a bank of 6 Westinghouse FS40 lamps which delivered to the mice a total dose of 9.9 x 10(5) J/m2, delivered over 24 weeks. These diets significantly reduced the tumor burden per mouse induced by UV irradiation, however they did not influence tumor incidence. The combination of retinyl palmitate plus canthaxanthin was more effective than either agent alone at reducing autochthonous tumor growth, a result which has not been previously reported.
Gensler
H L
HL
Department of Radiation Oncology, University of Arizona College of Medicine, Tucson 85724.
Aickin
M
M
Peng
Y M
YM
D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D016644:Canthaxanthin; D002338:Carotenoids / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004224:Diterpenes; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D000084562:Retinyl Esters; D012867:Skin / Q000378:metabolism / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D002338:Carotenoids; D016644:Canthaxanthin