[Antianaphylactic components of Asarum forbsii Maxin].
From the ethyl acetate extract of Asarum forbesii Maxin, four new constituents, asarumin A(I), B(II), C(III) and D(IV), were isolated along with elemicin (V), trans-asarone(VI) and linoleic acid(VII). The structures of the new compounds were elucidated as methyl 3 S-benzoyloxy-2 S-hydroxy-2-isopropylbutyrate for I, methyl 2 R-benzoyloxyisopentanoate for II, methyl 2 R-trans-cinnamoyloxyisopentanoate for III and methyl 2 R-piperonyloyloxyisopentanoate for IV. Compounds I, II, III and VII showed weak inhibition of PCA in rats, but the other compounds were inactive.
Bian
R L
RL
Department of Antiasthmatic Drugs, Zhejiang Medical University.
Xie
Q M
QM
Kobayashi
M
M
Asai
M
M
Ishiguro
T
T
Kishi
T
T
D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D014631:Valerates / Q000737:chemistry / Q000302:isolation & purification*
D001565:Benzoates; D002087:Butyrates; D002934:Cinnamates; D004365:Drugs, Chinese Herbal; D008041:Linoleic Acids; D014631:Valerates; C069458:asarumin A; C069459:asarumin B; C069460:asarumin C; D019787:Linoleic Acid