title: Influence of central and peripheral norepinephrine on the antibody response.
abstract: This paper intends to study the effect on the antibody response of profound, or mild variations of (central and peripheral) noradrenergic activity. An intraperitoneal injection of 6-hydroxydopamine (100 mg/kg) at the time of immunization impaired the anti-sheep-erythrocyte antibody response in both normal mice and in mice previously denervated with 6-hydroxydopamine; treatment with 6-hydroxydopamine, 7 days before immunization, did not affect the response. This suggests either a direct effect of the neurotoxin on the antibody response or an indirect effect via denervation and supersensitivity. Therapeutic doses of guanethidine (0.5-2.5 mg/kg) which do not damage the adrenergic axons, affected marginally and transiently the antibody response to sheep erythrocytes. Intracisternal injection of 6-hydroxydopamine (a 75-ug pulse, or three 25-ug pulses), DSP4 (a 75-ug pulse), or guanethidine (three 100-ug pulses) did not alter either the anti-trinitrophenyl natural-antibody response or the anti-sheep-erythrocyte antibody response. Swimming (at 32 degrees C) transiently and slightly enhanced the anti-sheep-erythrocyte (IgM) antibody response. It is proposed that the physiological fluctuations in the level of (central or peripheral) noradrenergic activity transiently and minimally influence the antibody response.
authors.affiliation: Department of Microbiology and Immunology, A.B. Chandler Medical Center, University of Kentucky, Lexington.
authors.forename: J
authors.initials: J
authors.lastname: Vidal
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001596:Benzylamines / Q000494:pharmacology; D002490:Central Nervous System / Q000502:physiology*; D002946:Cisterna Magna; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D007274:Injections, Intraperitoneal; D051379:Mice; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D010525:Peripheral Nerves / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology; D013563:Sympathectomy, Chemical; D013566:Sympathomimetics / Q000494:pharmacology
chemical_list: D001596:Benzylamines; D006892:Hydroxydopamines; D013566:Sympathomimetics; D016627:Oxidopamine; C012102:DSP 4; D009638:Norepinephrine; D006145:Guanethidine