title: [Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract].
abstract: Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically. A high concentration (0.075%) FR74366 showed sufficient effects both to prevent and reverse cataract, but low concentrations (0.025%) FR74366 was not effective as 0.075% FR74366. These results indicate that FR74366 can be useful drug for cataract.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Ikebe
authors.forename: H
authors.initials: H
authors.lastname: Terubayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Akagi
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005690:Galactose; D011799:Quinazolines / Q000627:therapeutic use*; D051381:Rats; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
chemical_list: D011799:Quinazolines; C064920:FR 74366; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; D005690:Galactose