[The effect of the newly synthesized barbiturate HB-7, phenobarbital and pentobarbital on the GABA content of the brain in rats].
The content of GABA in the following regions of the brain: cerebellum, left and right hemisphere was studied on white male rats. The determination was made by the method of Sutton and Simmonds (1974). One control and 7 experimental groups were investigated. All examined substances were administered intraperitoneally and the animals were decapitated at their peak activity. The effect of newly synthesized hydroxyl amine barbiturate HB-7, administered in several doses, was studied, comparing it with the action of pentobarbital (PB) and of phenobarbital (PB). A considerable increase in the content of barbiturates was established in the cerebellum of rats under the influence of the applied barbiturates while the content of GABA in both large hemispheres was less affected by the administered compounds. A conclusion is made that a single administration of barbiturates affects the content of GABA in some cerebral structures of the rat.
Getova
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D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D010424:Pentobarbital / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000187:drug effects*
D000927:Anticonvulsants; C056510:2-hydroxylamine-5-ethyl-5-sec-pentylbarbituric acid; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D010634:Phenobarbital
Vliianie na novosinteziraniia barbiturat HB-7, fenobarbitala i pentobarbitala vŭrkhu sŭdŭrzhanieto na GAMK v mozŭk na plŭkh.