title: [Lymphocyte subpopulations in the evolution of brucellosis].
abstract: We have sequentially studied for one year CD3+, CD4+, CD8+, CD11b+, and CD20+ lymphocyte subpopulations in 52 brucellosis patients whose diagnosis was confirmed by hemoculture. We observe at diagnosis a decreased percentage of CD4+ lymphocytes with an increase in CD8+ and inverted CD4+/CD8+ ratio, which was greater in patients with an evolution longer than 4 weeks (p less than 0.05) returning to normal very slowly. The percentage of monocytes was also increase at diagnosis (p less than 0.01) and at their second month CD3+ an CD20+ subpopulations did not suffer any changes during the follow up period. Patients were divided into two groups according to whether one or two anti-Brucella IgG peaks were observed in ELISA throughout the evolution. Patients in whom IgG titer decreased uninterruptedly, the inversion of the ratio during the first two months was greater, while those patients who suffered a relapse showed a simultaneous new decrease in CD4/CD8 ratio (p less than 0.05).
authors.affiliation: Servicios de Inmunología, Hospital Universitario San Carlos.
authors.forename: E
authors.initials: E
authors.lastname: Gazapo
authors.forename: J
authors.initials: J
authors.lastname: González Lahoz
authors.forename: J L
authors.initials: JL
authors.lastname: Subiza
authors.forename: M
authors.initials: M
authors.lastname: Baquero
authors.forename: M A
authors.initials: MA
authors.lastname: Figueredo
authors.forename: E
authors.initials: E
authors.lastname: Gómez de la Concha
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D002003:Brucella abortus / Q000276:immunology; D002006:Brucellosis / Q000188:drug therapy / Q000276:immunology*; D002469:Cell Separation / Q000379:methods; D004359:Drug Therapy, Combination; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016131:Lymphocyte Subsets / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Subpoblaciones linfocitarias en la evolución de la brucelosis.