A non-archimedean theory of interaction of chemical compounds with membranes.
The permeability of procaine across axon membranes and the effect of formaldehyde (FA), crotonic aldehyde (CA) and glutaraldehyde (GA) on the compound action potential of frog sciatic nerve was studied by utilizing a non-archimedean (NA) model of the relaxation process. Such models allow a characterization of biosystems exhibiting more than one time scale. Expansions using Laguerre polynomials have been obtained for relaxation functions. The new approach is tested by fitting the model to the experimental data of other authors, and then applying to extract molecular level information from macroscopic data.
Iordache
O
O
Polytechnical Institute of Bucharest, Department of Chemical Engineering, Romania.
Isopescu
R
R
Isopescu
A
A
Frangopol
P T
PT
D000200:Action Potentials; D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D005557:Formaldehyde / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology; D008433:Mathematics; D008566:Membranes / Q000502:physiology*; D008954:Models, Biological; D008959:Models, Neurological; D011343:Procaine / Q000378:metabolism*; D011898:Ranidae; D012584:Sciatic Nerve / Q000502:physiology*
D000447:Aldehydes; D005557:Formaldehyde; D011343:Procaine; C012796:2-butenal; D005976:Glutaral