title: Tissue plasminogen activator in peripheral arterial thrombolysis.
abstract: Thirty acute peripheral arterial thromboses in 28 patients were treated with local low-dose intra-arterial recombinant tissue plasminogen activator (t-PA). All patients received 0.5 mg h-1 t-PA and 15 also received 250 units h-1 of intra-arterial heparin. Overall limb salvage at 30 days was 83 per cent (25 out of 30 limbs). Mean(s.d.) ankle/brachial index was increased by 0.53(0.26) and there was no significant difference between the group receiving t-PA alone and that receiving t-PA and heparin. No strokes or major haemorrhages occurred but there were four (13 per cent) minor haematomas associated with the catheter entry site. There were four (13 per cent) deaths from myocardial infarction occurring between 5 and 21 days after treatment. Rethrombosis occurred in four cases (13 per cent). In two patients following t-PA alone, rethrombosis occurred after 2 and 11 days. Limb salvage was achieved with a successful repeat thrombolysis and a femoropopliteal graft respectively. Rethrombosis after t-PA and heparin occurred after 30 days in two patients due to poor run-off and extensive proximal atheromatous disease respectively. t-PA is a safe, effective thrombolytic agent when given as a low-dose intra-arterial infusion. The addition of low-dose heparin does not produce any significant benefit.
authors.affiliation: Department of Vascular Surgery, University Hospital, Nottingham, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Berridge
authors.forename: R H
authors.initials: RH
authors.lastname: Gregson
authors.forename: G S
authors.initials: GS
authors.lastname: Makin
authors.forename: B R
authors.initials: BR
authors.lastname: Hopkinson
mesh_terms: D000208:Acute Disease; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D006801:Humans; D007866:Leg / Q000098:blood supply; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator