title: Effect of low mole fraction of trehalose dicorynomycolate from Corynebacterium diphtheriae on water permeability and electrical capacitance of lipid bilayer membranes.
abstract: The effect of incorporation of different proportions of trehalose dicorynomycolates (TDC) into lecithin bilayer membranes was studied. It was found that TDC, induces a 14% decrease of water osmotic permeability (42.6 +/- 3.9 to 36.8 +/- 2.7 microns/s) at 1.6 mole%, suggesting that this substance leads to an increase of the degree of packing of the constituent lipid molecules. A condensing effect of TDC was also apparent from membrane electrical capacitance (Cm) measurement. By incorporating TDC into bilayer membranes, the value of Cm experienced a decrease of 29% at 1.6% mole fraction. This finding was taken to reflect an increase in membrane thickness, known in many examples, to be related to the condensing effect.
authors.affiliation: Instituto de Física e Química de São Carlos da Universidade de São Paulo, Departamento de química e Física Molecular, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Imasato
authors.forename: J
authors.initials: J
authors.lastname: Procópio
authors.forename: M
authors.initials: M
authors.lastname: Tabak
authors.forename: T
authors.initials: T
authors.lastname: Ioneda
mesh_terms: D003311:Cord Factors; D003353:Corynebacterium diphtheriae; D004553:Electric Conductivity; D006017:Glycolipids; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010539:Permeability; D014867:Water / Q000493:pharmacokinetics*
chemical_list: D003311:Cord Factors; D006017:Glycolipids; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D014867:Water; C043399:6,6'-dicorynomycolyl trehalose