title: Ultrasonographic assessment of urinary tract lesions due to Schistosoma haematobium in Niger after four consecutive years of treatment with praziquantel.
abstract: A comparative study on the extent of urinary tract abnormalities detected by ultrasound was conducted in two villages in an irrigated area of Niger where the pretreatment prevalences were 64.3% and 58.8% respectively. Fewer bladder lesions (20% of abnormalities) and fewer renal lesions (6% of abnormalities) were observed after four consecutive years of follow-up and treatment with praziquantel in the study village as compared to the control village where 54% bladder abnormalities and 36% renal abnormalities were observed. This study suggests that morbidity due to Schistosoma haematobium infection can be reduced by annual treatment over several years in a highly endemic area without other associated interventions.
authors.affiliation: Laboratoire des Schistosomoses CERMES, OCCGE/ORSTOM, Niamey, Niger.
authors.forename: C
authors.initials: C
authors.lastname: Laurent
authors.forename: F
authors.initials: F
authors.lastname: Lamothe
authors.forename: M
authors.initials: M
authors.lastname: Develoux
authors.forename: B
authors.initials: B
authors.lastname: Sellin
authors.forename: F
authors.initials: F
authors.lastname: Mouchet
mesh_terms: D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D009548:Niger / Q000453:epidemiology; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D015995:Prevalence; D012553:Schistosomiasis haematobia / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D014463:Ultrasonography; D001743:Urinary Bladder / Q000473:pathology*; D014556:Urine / Q000469:parasitology
chemical_list: D011223:Praziquantel