Circadian variation of methyleugenol anesthesia in albino rats.
In Wistar rats synchronized to a 12-h light/12-h dark cycle (lights on from 08:00 to 20:00 h), the ip injection of methyleugenol (200 mg/kg) at 08:00, 12:00 and 16:00 h significantly increased the sleeping time (time between loss and recovery of righting reflex) when compared to animals anesthetized at 20:00, 24:00 and 04:00 h. These data provide another example of the importance of circadian rhythms in biological systems and their practical relevance to pharmacology.
Sousa
M B
MB
Departamento de Fisiologia, Universidade Federal do Rio Grande do Norte, Natal, Brasil.
Ximenes
M F
MF
Mota
M T
MT
Moreira
L F
LF
Menezes
A A
AA
D000758:Anesthesia; D000777:Anesthetics; D000818:Animals; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D005054:Eugenol / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000777:Anesthetics; C005223:methyleugenol; D005054:Eugenol