title: Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia.
abstract: The known triterpenes 3-oxofriedelan-29-oic acid [1], 3-oxofriedelan-28-oic acid [2], and 28,29-dihydroxyfriedelan-3-one [3] have been isolated from Maytenus diversifolia. Compounds 1-3 demonstrated cytotoxicity against the A-549 lung carcinoma cells with ED50 values of 0.21, 1.18, and 0.64 micrograms/ml, respectively.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
authors.forename: H
authors.initials: H
authors.lastname: Nozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
authors.forename: S
authors.initials: S
authors.lastname: Hirono
authors.forename: R
authors.initials: R
authors.lastname: Kasai
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes