Specific responses to two unrelated antigens in mice made orally tolerant to one of them.
BDF1 and B10 mice, either normal or exclusively fed egg white diluted in water, were immunized with ovalbumin (OVA), sheep erythrocytes (SRBC) or OVA + SRBC. BDF1, but not B10, mice became tolerant to OVA and presented a 100% increase in the total number of immunoglobulin-secreting cells in the spleen. Immunization with OVA + SRBC markedly increased the response to OVA, except in tolerant BDF1 mice, and had no effect on the anti-SRBC PFC response, except in normal (non-tolerant) BDF1 mice.
Carvalho
C R
CR
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Vaz
N M
NM
D000818:Animals; D000918:Antibody Specificity / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
D010047:Ovalbumin