[Anti-HCV and long-term prognosis in patients with non-A, non-B post-transfusion hepatitis].
Anti-HCV was tested in serial serum samples of 20 patients with non-A, non-B post-transfusion hepatitis (NANB-PTH) who had been followed for more than 3 years after the onset. The rate of chronicity of disease was significantly higher in anti-HCV positive patients (12 out of 14, 85.7%) than in anti-HCV negative patients (group 1) (1 out of 6 patients, 14.3%). Among 14 anti-HCV positive patients, 7 lost anti-HCV during the follow-up period (group 2) and 6 of these 7 patients revealed normalization of liver dysfunction before or after the disappearance of anti-HCV. To the contrary, remaining 7 patients whose anti-HCV sustained positive (group 3) did show persistent abnormal liver function tests. Anti-HCV titer was significantly higher in group 3 than in group 2 at the point of 1 year after PTH. The titration of anti-HCV at 1 year after the onset of PTH was thought to be useful for estimating the prognosis of patients with post-transfusion hepatitis type C.
Tanaka
E
E
Second Department of Internal Medicine, Shinshu University School of Medicine.
Kiyosawa
K
K
Sodeyama
T
T
Nakano
Y
Y
Shimizu
S
S
Seki
T
T
Furuta
S
S
Kameko
M
M
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006508:Hepatitis Antibodies / Q000378:metabolism*; D006526:Hepatitis C / Q000276:immunology* / Q000635:transmission; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D065227:Transfusion Reaction
D006508:Hepatitis Antibodies