title: Antibacterial activity of fluoroquinolones in combination with zidovudine.
abstract: Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or Pseudomonas aeruginosa. Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.
authors.affiliation: Department of Bacteriology, University of Edinburgh Medical School.
authors.forename: C S
authors.initials: CS
authors.lastname: Lewin
authors.forename: R A
authors.initials: RA
authors.lastname: Allen
authors.forename: S G
authors.initials: SG
authors.lastname: Amyes
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D015365:Enoxacin / Q000008:administration & dosage*; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000008:administration & dosage*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D015363:Quinolones; D012475:Salmonella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D015215:Zidovudine / Q000008:administration & dosage*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015365:Enoxacin; D015215:Zidovudine; D002939:Ciprofloxacin; D015242:Ofloxacin; C053091:lomefloxacin