The cellular functions of small GTP-binding proteins.
A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.
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Chester Beatty Laboratories, Institute of Cancer Research, London, Great Britain.
D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D011905:Genes, ras; D008954:Models, Biological; D015689:Oncogene Protein p21(ras) / Q000502:physiology*; D018631:ras Proteins
D005656:Fungal Proteins; D019204:GTP-Binding Proteins; D015689:Oncogene Protein p21(ras); D018631:ras Proteins