Structure and activities of the ski oncogene.
The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusion protein with N-terminal gag and other viral sequences. The cellular homologue of v-ski, c-ski, is a large gene comprising at least 70 kb and containing at least seven coding exons. V-ski consists of most of the first five coding exons of c-ski. The proteins encoded by both genes are nuclear proteins that bind DNA and contain recognised motifs common to known nuclear regulatory proteins. A c-ski-related gene called sno has also been recently identified and, like c-ski, it is expressed in several human tumour cell lines.
Colmenares
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Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, OH 45267-0524.
Stavnezer
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D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009857:Oncogenes / Q000235:genetics / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C060614:SKI protein, human