title: Recovery of impaired pretreatment spermatogenesis in testicular cancer.
abstract: Light microscopic sperm analysis was done 24 months after treatment or later in 25 patients with testicular cancer with azoospermia or severe oligospermia (sperm cell count less than 10 x 10(6)/mL) after orchiectomy before further treatment. Treatment after orchiectomy consisted of abdominal irradiation, cisplatin-based chemotherapy, retroperitoneal surgery, a combination of the former treatment modalities, or a surveillance policy. At the time of post-treatment reassessment, 15 of the 25 patients had sperm cell concentrations of at least 10 x 10(6)/ml (7 of 14 patients in the azoospermia group; 8 of 11 patients in the oligospermia group). Eight patients fathered a child after discontinuation of treatment for testicular cancer. Recovery of spermatogenesis could be seen after all types of treatment. A highly increased pretreatment serum follicle-stimulating hormone was correlated with lack of sperm cell production recovery.
authors.affiliation: Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Oslo.
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: L
authors.initials: L
authors.lastname: Theodorsen
authors.forename: N
authors.initials: N
authors.lastname: Norman
authors.forename: T
authors.initials: T
authors.lastname: Aabyholm
mesh_terms: D000328:Adult; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009919:Orchiectomy; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology; D013736:Testicular Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D013737:Testis / Q000187:drug effects / Q000601:surgery
chemical_list: D005640:Follicle Stimulating Hormone; D002945:Cisplatin