[Changes in platelet aggregation, TXB2 and 6-keto-PGF1 alpha in surgical shock].
Platelet aggregation rate (PAR), plasma concentration of TXB2 and 6-Keto-PGF1 alpha were measured in 26 patients with shock (hypovolumic shock 10 and septic shock 16) and 10 controls. PAR, plasma TXB2 and 6-Keto-PGF1 alpha were increased during shock, with TXB2 increased more significantly than 6-Keto-PGF1 alpha, accordingly the TXB2/6-Keto-PGF1 alpha ratio were raised during shock, especially in the septic cases. PAR, plasma TXB2 and 6-Keto-PGF1 alpha will decrease while shock become subsiding, and elevate while shock become irreversible. As a rule, the change of PAR is parallel with the concentration of plasma TXB2. The speed of platelet aggregation and plasma TXB2 concentration were higher in eleven mortal cases.
Tian
L
L
Third Affiliated Hospital, Norman Bethune University of Medical Sciences, Changchun.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011379:Prognosis; D012773:Shock, Surgical / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha