Adaptation of jejunal to colonic mucosal autografts in experimentally induced short bowel syndrome.
The behavior of jejunal to colonic mucosal autografts was studied in an experimental animal model of short bowel syndrome (SBS). Histological appearances, enterocyte enzyme activities, and in vitro glucose transport were studied at the donor and recipient graft sites in control, short-bowel syndrome, and gastrocolic fistula 5-week-old Sprague-Dawley rats. Small intestinal function was maintained in the jejunocolonic graft after 80% small bowel resection; animals in which small bowel was not resected showed loss of graft function and enzyme activity. This effect is dependent on the presence of jejunal chyme: after gastrocolic fistulae, the jejunum to colon grafts lost jejunal functional activities. Total parenteral nutrition did not alter graft behavior but improved the postoperative mortality of the procedures. The results provide additional information on intestinal adaptation in SBS.
Banerjee
A K
AK
Department of Clinical Biochemistry, King's College Hospital Medical School, London, UK.
Chadwick
S J
SJ
Peters
T J
TJ
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D003106:Colon; D005766:Gastrointestinal Contents; D005947:Glucose / Q000493:pharmacokinetics; D006085:Graft Survival / Q000502:physiology; D007408:Intestinal Absorption / Q000502:physiology; D007413:Intestinal Mucosa / Q000637:transplantation*; D007583:Jejunum / Q000637:transplantation*; D008286:Malabsorption Syndromes / Q000601:surgery*; D008297:Male; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D012778:Short Bowel Syndrome / Q000503:physiopathology / Q000601:surgery*; D016042:Transplantation, Heterotopic
D005947:Glucose