[The role of prostacyclin and thromboxane in the antihypertensive action of enalapril].
Enalapril produces an inhibition of the angiotensin-renin system, correlating the pre-therapy plasmatic renin activity with blood pressure decrease, during its administration. This does not always happen, data to the contrary existing in literature, suggesting that there are some other acting mechanisms. We studied 34 hypertensive patients, whose blood pressure levels were controlled by Enalapril at a mean dosage of 12.32 +/- 0.9. Determining plasmatic concentration of 6-keto PGF1a (a prostacyclin metabolite), T x B2 (a thromboxane A2 metabolite), their distribution, plasmatic renin activity and a radiological and biochemical study. We found a significant increase in their distribution and plasmatic renin at the end of the essay. The results suggest a possible double active mechanism: angiotension-renin and prostaglandins systems, owing to the imbalance occurring between prostacyclin and thromboxane, the first named being the most favoured. This, together with easy application and the lack of side effects, made this drug useful for treatment of blood hypertension.
Suárez Morano
J
J
Departamento de Medicina Interna, Universitario Virgen del Rocío, Sevilla.
Oliván Martínez
J
J
Castillo Ferrando
J R
JR
Garrido Peralta
M
M
Serrano Molina
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D013929:Thromboxane B2 / Q000097:blood*; D013997:Time Factors
D011460:Prostaglandins F; D013929:Thromboxane B2; D004656:Enalapril; D011464:Epoprostenol; C100006:prostaglandin F1
Papel de la prostaciclina y tromboxano en la acción antihipertensiva del enalapril.