Symptoms and well-being during antihypertensive treatment with thiazide diuretics.
Diuretic drugs seem to be well tolerated during long-term antihypertensive treatment. Although they induce severe side effects necessitating withdrawal more often than placebo, the frequency of such withdrawals seem to be equal to that induced by beta-blocker treatment. The subjective tolerability as judged by questionnaires for symptoms and well being scores seems to indicate an over-all small improvement in patient well being. The effects in this respect seem to be similar to those exerted by a selective beta-blocker.
Berglund
G
G
Department of Medicine, General Hospital, Malmö, Sweden.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics; D004311:Double-Blind Method; D005260:Female; D006304:Health Status; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010919:Placebos; D011788:Quality of Life; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000523:psychology; D011795:Surveys and Questionnaires
D004232:Diuretics; D010919:Placebos; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D008790:Metoprolol