Hemodynamic effects of Gd-DTPA administered via rapid bolus or slow infusion: a study in dogs.
The hemodynamic effects of rapid (10 sec) versus slow (1 min) IV injection of Gd-DTPA were compared in normal, pentobarbital-anesthetized mongrel dogs. Hypertonic mannitol and isotonic saline were used as equiosmotic and equivolumetric controls. Two dose levels of Gd-DTPA were administered: 0.1 mmol/kg and 0.5 mmol/kg, corresponding to dose volumes of 0.2 and 1.0 ml/kg, respectively. The rapid injection of a high dose (0.5 mmol/kg) produced a transient decrease in arterial blood pressure (21 mm Hg, p less than .001), which returned to control values within 1 min after the injection. Slow IV infusion at this high dose had no statistically significant hemodynamic effects. There were no statistically significant effects of the lower dose (0.1 mmol/kg) administered as a bolus or by infusion, nor of the saline or osmotic control solutions. These results suggest that acute hemodynamic effects of Gd-DTPA are not observed at clinically relevant doses and the vasodilation observed at a higher dose may result from a direct action of the contrast agent.
Sullivan
M E
ME
Berlex Laboratories, Inc., Wayne, NJ.
Goldstein
H A
HA
Sansone
K J
KJ
Stoner
S A
SA
Holyoak
W L
WL
Wiggins
J R
JR
D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D019786:Gadolinium DTPA; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D004369:Pentetic Acid / Q000008:administration & dosage* / Q000494:pharmacology
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA