title: Plasma von Willebrand factor concentration and thyroid function in dogs.
abstract: Plasma von Willebrand factor antigen concentration was determined in 15 dogs with suspected hypothyroidism, in 1 dog with hyperthyroidism, and in 14 euthyroid dogs. The mean +/- SEM von Willebrand factor:antigen concentration in hypothyroid dogs (47.1% +/- 12.6%) was significantly decreased (P less than 0.0005), compared with that in euthyroid dogs (94.7 +/- 5.6%). Four hypothyroid dogs were given thyroxine for 1 month and all 4 had an increase in von Willebrand factor:antigen concentration. The plasma von Willebrand factor:antigen concentration was 200% in the hyperthyroid dog. Seemingly, reduced concentrations of plasma von Willebrand factor:antigen can be found in dogs in association with congenital von Willebrand disease or with von Willebrand disease acquired through hypothyroidism.
authors.affiliation: Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
authors.forename: S
authors.initials: S
authors.lastname: Avgeris
authors.forename: C D
authors.initials: CD
authors.lastname: Lothrop
authors.forename: T P
authors.initials: TP
authors.lastname: McDonald
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000276:immunology; D004285:Dogs; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000276:immunology / Q000662:veterinary; D007037:Hypothyroidism / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D008297:Male; D011863:Radioimmunoassay / Q000662:veterinary; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*; D014842:von Willebrand Diseases / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis* / Q000276:immunology
chemical_list: D014841:von Willebrand Factor; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine