title: Iron overload in untransfused patients with hemoglobin H disease.
abstract: Two Chinese patients with hemoglobin (Hb) H disease without a history of blood transfusion developed iron overload at the age of 45 and 53 years, respectively. Human leukocyte antigen (HLA) system types of these 2 patients were A19, A11, B13, B62 and A2, A24, BW55, respectively, which are not related to the common haplotypes for idiopathic hemochromatosis. Since severe iron loading is a rare clinical manifestation in untransfused patients with Hb H disease, the iron overload in both patients may be due to environmental or underlying genetic factors.
authors.affiliation: Division of Hematology, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: H W
authors.initials: HW
authors.lastname: Peng
authors.forename: C H
authors.initials: CH
authors.lastname: Ho
authors.forename: C H
authors.initials: CH
authors.lastname: Yung
mesh_terms: D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000235:genetics / Q000378:metabolism*
chemical_list: D007501:Iron