The effect of treatment with interferon-gamma on type II collagen-induced arthritis.
We have investigated the effects of recombinant murine interferon-gamma (rIFN-gamma) on type II collagen-induced arthritis (CA) in DBA/l mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN-gamma, at 10(5) U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti-CII antibody responses may partly explain the inhibition of CA by rIFN-gamma. The possible role of the anti-inflammatory effect of systemic IFN-gamma in the inhibition of CA is discussed.
Nakajima
H
H
Research Institute, Daiichi Pharmaceutical Co., Tokyo, Japan.
Takamori
H
H
Hiyama
Y
Y
Tsukada
W
W
D000818:Animals; D001168:Arthritis / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis; D007371:Interferon-gamma / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D011994:Recombinant Proteins
D007074:Immunoglobulin G; D011994:Recombinant Proteins; D007371:Interferon-gamma; D003094:Collagen