Effect of x-radiation to brain on cerebral glucose utilization in the rat.
We assessed, by means of the [14C]-2-deoxy-D-glucose autoradiography method, the effect of whole-brain x-radiation on local cerebral glucose utilization in the rat brain. Animals were exposed to conventional fractionation (200 +/- cGy/day given 5 days a week) to a total dose of 4000 cGy. Metabolic experiments were made 2 weeks after completion of the radiation exposure. In comparison with control and sham-irradiated animals, cerebral metabolic activity was diffusely decreased following irradiation. Statistically significant decreases in metabolic activity were observed in 13 of 27 brain regions studied. In general, brain areas with the highest basal metabolic rates showed the greatest percentage drop of glucose utilization. Post-irradiation metabolic alterations possibly provide an explanation for the syndrome of early delayed deterioration observed in humans after whole-brain radiotherapy.
D'Aquino
S
S
Institute of Oncology, Faculty of Medicine, University of Messina, Italy.
Cicciarello
R
R
D'Avella
D
D
Mesiti
M
M
Albiero
F
F
Princi
P
P
Gagliardi
M E
ME
Russi
E
E
D'Aquino
A
A
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects*; D002250:Carbon Radioisotopes; D016371:Cranial Irradiation; D003847:Deoxyglucose; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D003847:Deoxyglucose; D005947:Glucose