title: Is vitamin D necessary for skeletal integrity in the elderly?
abstract: Serum 1.25 dihydroxyvitamin D concentrations were reduced in elderly patients with femoral neck fractures, irrespective of the presence of osteomalacia. This reduction was not attributable to a decrease in vitamin D binding protein. The low rate of bone turnover in these elderly patients might reduce the requirement for vitamin D and protect against the development of osteomalacia. Serum vitamin D metabolite concentration cannot be used as a screening test for osteomalacia in these patients.
authors.affiliation: Department of Biochemistry, University Hospital, Queen's Medical Centre, Nottingham, England.
authors.forename: S P
authors.initials: SP
authors.lastname: Thompson
authors.forename: T J
authors.initials: TJ
authors.lastname: Wilton
authors.forename: D J
authors.initials: DJ
authors.lastname: Hosking
authors.forename: D A
authors.initials: DA
authors.lastname: White
authors.forename: E
authors.initials: E
authors.lastname: Pawley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002117:Calcitriol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005265:Femoral Neck Fractures / Q000097:blood / Q000188:drug therapy; D006801:Humans; D005779:Immunodiffusion; D008875:Middle Aged; D010018:Osteomalacia / Q000097:blood / Q000188:drug therapy; D011485:Protein Binding; D064030:S100 Calcium Binding Protein G / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000188:drug therapy
chemical_list: D064030:S100 Calcium Binding Protein G; D014807:Vitamin D; D002117:Calcitriol