Effects of triglycylvasopressin on portal pressure and portal bile acid concentration in normal and cirrhotic rats.
The effects of triglycylvasopressin on portal vein pressure and portal bile acid concentration after oral loading with chenodeoxycholic acid were evaluated in normal and cirrhotic rats. Triglycylvasopressin significantly reduced the portal vein pressure and portal bile acid concentration in both populations (normal: portal vein pressure 21.2%, p less than 0.05; portal bile acid concentration 43.2%, p less than 0.005; cirrhotic: portal vein pressure 19.8%, p less than 0.025; portal bile acid concentration 20.3%, p less than 0.05). Both in normal and cirrhotic rats, portal vein pressure and portal bile acid concentration resulted correlated. These results support that the combined determination of portal vein pressure and portal bile acid concentration could represent an interesting approach to the study of drugs which are potentially active on portal circulation and could indirectly provide information as to portal flow.
Testa
R
R
Department of Gastroenterology, University of Genova, Italy.
Ghia
M
M
Mereto
E
E
Dagnino
F
F
Grasso
A
A
Lapertosa
G
G
Celle
G
G
D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008106:Liver Cirrhosis, Experimental / Q000097:blood*; D008236:Lypressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D011169:Portal Vein / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D000077585:Terlipressin
D001647:Bile Acids and Salts; D002635:Chenodeoxycholic Acid; D008236:Lypressin; D000077585:Terlipressin