[Contraceptives and ischemic cardiopathy].
The incidence of myocardial infarction is higher in women that use oral contraceptives. The most important pathophysiologic mechanisms are: a) modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus; b) blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity. At this moment there are several update publications concerning this matter; however most of the mechanisms involved in the increase of coronary heart disease in this specific group still remain unclear.
García-Bolao
I
I
Departamento de Cardiología y Cirugía Cardiovascular, Facultad de Medicina, Universidad de Navarra, Pamplona.
Alegría
E
E
Iglesias
I
I
Velasco
S
S
Alzamora
P
P
Fidalgo
M L
ML
D001161:Arteriosclerosis / Q000139:chemically induced; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D002784:Cholesterol / Q000378:metabolism*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D003327:Coronary Disease / Q000139:chemically induced*; D003920:Diabetes Mellitus / Q000139:chemically induced; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D011372:Progestins / Q000009:adverse effects; D013329:Structure-Activity Relationship
D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D011372:Progestins; D002784:Cholesterol
Contraceptivos y cardiopatía isquémica.