title: Indium-111-labeled leukocyte scintigraphy in hemodialysis access-site infection.
abstract: Bacterial sepsis, a significant complication of chronic hemodialysis, is generally the result of infection at the vascular access site. We retrospectively reviewed the utility of indium-111-(111In) labeled autologous leukocyte scintigraphy in 26 patients (30 scans) with synthetic vascular grafts, on chronic hemodialysis, in whom hemodialysis access site infection was a diagnostic consideration. Leukocyte scintigraphy correctly identified all fifteen access-site infections; there was one false-positive study, for an overall sensitivity and specificity of 100% and 93%, respectively. Of particular significance is the fact that in nine (60%) of the fifteen access-site infections, physical examination was normal. Our data indicate that 111In-labeled leukocyte scintigraphy is a useful procedure for the diagnosis of hemodialysis access-site infection, and it is especially valuable when physical examination of the access site is normal.
authors.affiliation: Andre Meyer Department of Physics-Nuclear Medicine, Mt. Sinai School of Medicine, New York, New York 10029.
authors.forename: C J
authors.initials: CJ
authors.lastname: Palestro
authors.forename: A
authors.initials: A
authors.lastname: Vega
authors.forename: C K
authors.initials: CK
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Vallabhajosula
authors.forename: S J
authors.initials: SJ
authors.lastname: Goldsmith
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000000981:diagnostic imaging* / Q000209:etiology; D001807:Blood Vessel Prosthesis; D005260:Female; D006801:Humans; D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011138:Polytetrafluoroethylene; D011877:Radionuclide Imaging; D006435:Renal Dialysis; D012189:Retrospective Studies
chemical_list: D006912:Hydroxyquinolines; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline; D011138:Polytetrafluoroethylene