Viral persistence and immune dysfunction.
Viruses can persist for years without provoking an effective host immune response or otherwise causing the cell destruction characteristic of an acute viral infection. Clinically relevant principles, generalizable to many persistent viruses, are exemplified by measles and lymphocyte choriomeningitis viruses. The LCMV model indicates that viral persistence and the anergic state are reversible.
Oldstone
M B
MB
Department of Neuropharmacology, Scripps Clinic and Research Foundation, La Jolla, Calif.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*; D014780:Viruses / Q000235:genetics / Q000276:immunology
D000936:Antigen-Antibody Complex