Comparison of effects of magnesium valproate and sodium valproate on the action potential of isolated papillary muscle from guinea pigs and dogs.
A comparison of the effects of magnesium valproate (MV) and sodium valproate (SV) on the action potential of isolated papillary muscle from guinea pigs and dogs was made in this study. The results in both animals were as follows: MV and SV induced a slight reduction of slope plateau of action potential and prolongation of action potential duration (APD). What is more, APD50 and APD90 were prolonged significantly, thus the ratio of APD90/APD25 was increased. The effective refractory period (ERP) was prolonged significantly. MV or SV showed no effects on action potential amplitude, overshoot, resting potential and phase 0 upstroke velocity. The above results suggested that MV and SV might play an antiarrhythmic role and that their effects were analogic. The mechanism of MV and SV inducing significant prolongation of APD50, APD90, and ERP, might be closely related to the slow-down of the velocity of K+ efflux during plateau and repolarization of phase 3 by radical of valproate and the slow-down of velocity of K+ efflux of repolarization of phase 3 in particular. These results showed that there was no difference in SV and MV action on guinea pigs and dogs.
Ding
B C
BC
Department of Physiology, Hunan Medical University, Changsha.
Gao
Z Y
ZY
Wu
M
M
Pi
X J
XJ
Wang
H Q
HQ
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004285:Dogs; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010210:Papillary Muscles / Q000502:physiology*; D015221:Potassium Channels / Q000187:drug effects; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology*
D015221:Potassium Channels; D014635:Valproic Acid