[The humeral artery and clinical pharmacology].
Regional haemodynamic parameters such as blood flow, brachial artery diameter and forearm resistances may be measured or calculated non-invasively by pulsed Doppler techniques, and, in the absence of blood pressure changes, provide a method of observing and quantifying the vasomotor tone of small or large arteries. This type of study therefore allows characterisation of the vascular effects of drugs whether they be vasodilators or substances with a preferential mode of action on the myocardium. These effects can be situated with respect to the central hemodynamics in order to determine the presence of phenomena of regional redistribution of cardiac output, the regional vascular changes observed after taking a meal or in cardiac failure, with and without treatment; this should lead to a better understanding of the mode of action of drugs used in cardiovascular disease and also of the underlying physiopathological mechanisms.
Thuillez
C
C
Service de pharmacologie clinique, hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Giudicelli
J F
JF
D001132:Arm / Q000098:blood supply*; D001158:Arteries / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy; D004347:Drug Interactions; D006801:Humans; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents
Artère humérale et pharmacologie clinique.