title: Minimum airway pressure weaning. Weaning from mechanical ventilation at 50 breaths/minute by reduction of inflation pressure using a pressure generator.
abstract: Ten patients, whose lungs were ventilated initially with intermittent positive pressure ventilation at conventional rates after myocardial revascularisation or cardiac valvular surgery, were weaned using a valveless high frequency jet ventilator at a constant rate of 50 breaths/minute. The withdrawal of ventilation was achieved, when clinical criteria permitted, by reduction of the tidal volume preset on the jet ventilator in successive stages; this was effected by stepwise decreases in the jet driving pressure. This new mode of weaning at a constant rate of 50 breaths/minute is associated with minimum peak airway pressures. Synchronisation of the patient's breathing with the valveless ventilator is not required and weaning is tolerated well by the patient. Arterial oxygen tension and saturation were maintained throughout weaning and did not decline after extubation of the trachea.
authors.affiliation: Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London.
authors.forename: P S
authors.initials: PS
authors.lastname: Tan
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002245:Carbon Dioxide / Q000097:blood; D003422:Critical Care; D005260:Female; D006351:Heart Valves / Q000601:surgery; D006611:High-Frequency Jet Ventilation; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011312:Pressure; D013990:Tidal Volume; D015300:Ventilator Weaning / Q000379:methods*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen