title: Biological evaluation of 99mTc labelled cis-platinum containing benzyliminodiacetic acids as potential tumour imaging agents.
abstract: The synthesis of three new potential tumour-imaging radiopharmaceuticals in which a cis-platin derivative is attached to benzyl iminodiacetic acid, a ligand capable of forming a stable complex with 99mTc, has previously been reported by us [Awaluddin et al. Appl. Radiat. Isot. 38, 671-674 (1987)]. We have now carried out extensive biodistribution studies on these compounds as well as on two fragments of their structures which do not contain platinum. The results suggest that the presence of platinum is not essential for the tumour-localizing properties of the radiopharmaceuticals.
authors: Pharmacy Department, University of Queensland, St Lucia, Australia.
authors: J J
authors: JJ
authors: Jacobs
authors: D J
authors: DJ
authors: Maddalena
authors: J G
authors: JG
authors: Wilson
authors: A
authors: A
authors: Awaluddin
authors: J
authors: J
authors: King-Christopher
authors: D W
authors: DW
authors: Bourne
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D007098:Imino Acids / Q000493:pharmacokinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013047:Specific Pathogen-Free Organisms; D014018:Tissue Distribution
chemical_list: D007098:Imino Acids; D002945:Cisplatin