Selective induction of autocytotoxic activity through the CD3 molecule.
In the present study we show that when certain major histocompatibility complex-alloreactive CD8+ T cell clones with natural killer-like activity are stimulated through their CD3 molecules, in the absence of significant cross-linkage (as provided by Fab' fragments of OKT3 antibodies) they lose their interleukin 2 response. This is attributable to an induction of a nonspecific autocytolytic activity. These results suggest that activation of this process in some cytotoxic cells leads to an overall decrease in CTL activity and constitutes a possible mechanism of suppression of the immune response.
Bensussan
A
A
Hôpital Saint-Louis, INSERM, Paris.
Leca
G
G
Corvaïa
N
N
Boumsell
L
L
D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D001329:Autolysis; D017252:CD3 Complex; D002118:Calcium / Q000502:physiology; D002470:Cell Survival; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D002118:Calcium