title: Immune function in lines of mice selected for high or low degrees of behavioral asymmetry.
abstract: Cerebral lateralization has been suggested to play a regulatory role in immune function. In this study, several measures of immune function were evaluated in mice selectively bred for either a strong (HI) or weak (LO) degree of behavioral asymmetry (paw preference) and compared to an unselected control population (HET). Both HI and LO animals had fewer spleen cells but higher degrees of [3H]thymidine incorporation into DNA (on a per cell basis) than HET mice. However, only HI mice had lower immune functions compared to HET controls manifest as reduced mixed leukocyte reaction (MLR), cytotoxic T lymphocyte (CTL) activity, and natural killer (NK) cell activity. These findings indicate that although both extremes in the degree of paw preference may be associated with deviations from the norm, a high degree of behavioral lateralization is associated with decreased immune responsiveness in this animal model.
authors: Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
authors: E
authors: E
authors: Fride
authors: R L
authors: RL
authors: Collins
authors: P
authors: P
authors: Skolnick
authors: P K
authors: PK
authors: Arora
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D007107:Immune System / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D011598:Psychoneuroimmunology; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology