title: Cisplatin-induced anemia: a potential interference with iron metabolism at erythroid progenitors level.
abstract: To elucidate the potential mechanisms of anemia induced by cisplatin (CDDP) we have evaluated hemolysis, dyserythropoiesis, ferrokinetics and cytotoxicity on erythroid progenitors in 12 patients treated by a CDDP-containing combination chemotherapy and in 6 patients treated by a similar combination but without CDDP. Eight patients, from the CDDP treated group, experienced a pronounced anemia. None had signs of hemolysis. Ferrokinetic study showed a very deep and protracted decrease of 59Fe incorporation during the chemotherapy cycle and the following 2 weeks. These results, along with a normal medullary erythroblastic cellularity, suggest that CDDP induces a deep but transient erythropoiesis alteration leading to anemia in some cases.
authors: Service Onco-Hematologie, CHU Hautepierre, Strasbourg, France.
authors: P
authors: P
authors: Dufour
authors: J P
authors: JP
authors: Bergerat
authors: M
authors: M
authors: Eber
authors: P
authors: P
authors: Renaud
authors: V
authors: V
authors: Karcher
authors: C
authors: C
authors: Giron
authors: M J
authors: MJ
authors: Leroy
authors: F
authors: F
authors: Oberling
mesh_terms: D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D015672:Erythroid Precursor Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D010752:Phosphoramide Mustards / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D010752:Phosphoramide Mustards; D004317:Doxorubicin; D007501:Iron; D002945:Cisplatin