Modification of swine serum-induced bile duct lesion in BALB/c mice by cyclophosphamide.
Effects of cyclophosphamide (CY) on the antibody titer level and incidence and severity of swine serum (SS)-induced bile duct lesion (BDL) were examined. BDL induced by 0.2 ml of SS per head twice a week for 2 weeks was characterized by hyperplasia of biliary epithelial cells, proliferation of mucous glands, and periductal infiltration of eosinophils with mild fibrosis. CY showed no significant influence on the above-mentioned parameters at the dose levels of 140 and 210 mg/kg. On the other hand, CY lowered the antibody titer level and decreased the severity of BDL at the dose level of 280 mg/kg, and it suppressed the antibody response and BDL at the dose level of 280 x 2 mg/kg. Thus the antibody titer level and the severity of BDL were closely related each other.
Doi
K
K
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Honjo
K
K
Doi
C
C
Mitsuoka
T
T
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001652:Bile Ducts / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D001769:Blood / Q000276:immunology; D002761:Cholangitis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013552:Swine
D003520:Cyclophosphamide