Lack of effect of enoximone on the pharmacokinetics of digoxin in patients with congestive heart failure.
The aim of this study was to investigate if the concomitant administration of the positive inotropic drug enoximone (100 mg tid) has any effect on the morning through levels of the cardiac glycoside digoxin in 17 patients with congestive heart failure (NYHA II-IV). Plasma concentrations of digoxin were 1.05 +/- 0.37 ng/mL before enoximone, 0.95 +/- 0.31 ng/mL at the end of the enoximone treatment period of 1 week and 0.95 +/- 0.36 ng/mL 1 week after cessation of enoximone treatment. Thus, concomitant administration of enoximone had no effect on plasma concentrations of digoxin while on the other hand the hemodynamics as assessed by NYHA-classification and determination of the heart volume improved significantly.
Trenk
D
D
Department of Clinical Pharmacology, Rehabilitationszentrum, Bad Krozingen, Federal Republic of Germany.
Hertrich
F
F
Winkelmann
B
B
Glauner
T
T
Dieterich
H A
HA
Jähnchen
E
E
D000368:Aged; D000369:Aged, 80 and over; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017335:Enoximone; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D007093:Imidazoles; D004077:Digoxin; D017335:Enoximone