[Intravenous pentoxifylline in Fontaine stage II and III peripheral arterial diseases].
Thirty patients with lower limb arterial disease (15 Fontaine stage II, 15 stage III) were treated for two weeks with continuous pentoxifylline infusion (1 g daily). In all cases, a significant improvement of the Winsor index was obtained: in stage II from 0.57 +/- 0.11 to 0.67 +/- 0.15 (p less than 0.008), and in stage III from 0.43 +/- 0.20 to 0.58 +/- 0.19 (p less than 0.042). In patients who could be submitted to treadmill exercise, the average distance increased from 216 +/- 88 m to 314 +/- 187 m (p less than 0.05) while distance walked without pain increased from 124 +/- 76 m to 199 +/- 153 (p less than 0.05).
Giansante
C
C
Istituto di Clinica Medica Generale e Terapia Medica, Università degli Studi di Trieste.
Di Chiara
A
A
Fiotti
N
N
Mauri
F
F
Sorrentino
A
A
Spanghero
M
M
Tomasin
L
L
Calabrese
S
S
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage*
D010431:Pentoxifylline
La pentossifillina per via endovenosa nell'arteriopatia periferica al II e III stadio Fontaine.