title: Simulation of human sleep: ultradian dynamics of electroencephalographic slow-wave activity.
abstract: The typical declining trend of electroencephalographic (EEG) slow-wave activity (SWA) within a sleep period is represented in the two-process model of sleep regulation by an exponentially decaying process (Process S). The model has been further elaborated to simulate not only the global changes of SWA, but also the dynamics within non-rapid-eye-movement (non-REM) sleep episodes. In this new model, the initial intraepisodic buildup of SWA is determined by the combined action of an exponentially increasing process and a saturation process, whereas its fall at the end of an episode is due to an exponentially decreasing process. The global declining trend of SWA over consecutive episodes results from the monotonic decay of the intraepisodic saturation level. In contrast to Process S in the two-process model, this decay is not represented by an exponential function, but is proportional to the momentary level of SWA. REM sleep episodes are triggered by an external function. The model allows one to simulate the ultradian pattern of SWA for baseline nights as well as changes induced by a prolonged waking period, a daytime nap, a partial slow-wave sleep deprivation, or an antidepressant drug.
authors: Institute of Pharmacology, University of Zürich, Switzerland.
authors: P
authors: P
authors: Achermann
authors: A A
authors: AA
authors: Borbély
mesh_terms: D000161:Acoustic Stimulation; D000204:Activity Cycles / Q000502:physiology*; D000328:Adult; D002997:Clomipramine / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D008297:Male; D008959:Models, Neurological; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology
chemical_list: D002997:Clomipramine