Brain neurotransmitter changes in three patients who had a fatal hyperthermia syndrome.
The authors examined the autopsied brains from three patients who had a fatal hyperthermia syndrome. There was marked hypothalamic noradrenaline depletion in all three patients, severe brain choline acetyltransferase deficiency with nucleus basalis cell loss in two patients, and mild to moderate brain choline acetyltransferase loss in one patient. Striatal dopamine metabolite/dopamine ratio was below normal in two patients and not elevated, as would be expected after short-term neuroleptic administration, in the third. This suggests that reduced capability (aggravated by the cholinergic deficit) of the nigrostriatal dopamine system to respond adequately to stress and/or neuroleptic-induced receptor blockade may be important in the development and course of fatal hyperthermia syndrome.
Kish
S J
SJ
Clarke Institute of Psychiatry, University of Toronto, Ont., Canada.
Kleinert
R
R
Minauf
M
M
Gilbert
J
J
Walter
G F
GF
Slimovitch
C
C
Maurer
E
E
Rezvani
Y
Y
Myers
R
R
Hornykiewicz
O
O
D000293:Adolescent; D000328:Adult; D001344:Autopsy; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D001923:Brain Chemistry; D002389:Catatonia / Q000378:metabolism* / Q000473:pathology; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D003342:Corpus Striatum / Q000032:analysis / Q000473:pathology; D004298:Dopamine / Q000032:analysis*; D005260:Female; D005334:Fever / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007031:Hypothalamus / Q000032:analysis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000378:metabolism* / Q000473:pathology; D009638:Norepinephrine / Q000032:analysis*; D013377:Substantia Innominata / Q000032:analysis / Q000473:pathology; D013577:Syndrome
D002795:Choline O-Acetyltransferase; D004298:Dopamine; D009638:Norepinephrine