title: [Long-term effects of indapamide in left ventricular hypertrophy in patients with hypertension].
abstract: Left ventricular hypertrophy is a major and independent cardiovascular risk factor in hypertension. The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. At the end of the trial, the left ventricular mass index decreased significantly from 172 +/- 11 to 147 +/- 11 g/m2 (p less than 0.001). Therefore, in contrast to the other diuretics which have been studied, indapamide seems able to induce regression of the left ventricular hypertrophy complicating hypertension.
authors: Hôpital Pitié-Salpêtrière, Paris.
authors: M
authors: M
authors: Komajda
authors: K
authors: K
authors: Klimczak
authors: J
authors: J
authors: Evans
authors: B
authors: B
authors: Boutin
authors: F
authors: F
authors: Brackman
authors: D
authors: D
authors: Guez
authors: Y
authors: Y
authors: Grosgogeat
mesh_terms: D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007190:Indapamide
vernacular_title: Effets à long terme de l'indapamide sur l'hypertrophie ventriculaire gauche de l'hypertendu.