title: Retinol binding protein: a short half life determinant of protein non enzymatic glycation in diabetes.
abstract: The non enzymatic glycation of circulating and structural proteins is the main biochemical consequence of the chronic hyperglycaemia of diabetes mellitus. Retinol binding protein (RPB) is a 21K plasma globulin with an half life of 12 hr; its non enzymatic glycation may reflect the variation of short term metabolic control (1-4 days). In this study two blood samples were withdrawn at four days interval from 24 non insulin dependent diabetic patients. Glycated RBP was measured by a two-site immunoradiometric assay and its variations correlated with the correspondent changes in the blood glucose level. A significant correlation (r = 0.471; p less than 0.02) was found between the time 4/time 0 ratios of glycated RBP and the time 4/time 0 ratios of blood glucose. These data suggest that measurement of non-enzymatically glycated RBP may be a useful tool to evaluate the short term state of non enzymatic glycation in diabetes.
authors: Cattedra Endocrinologia, University of Rome La Sapienza, Italy.
authors: M
authors: M
authors: Sensi
authors: M R
authors: MR
authors: Bruno
authors: L
authors: L
authors: Valente
authors: G P
authors: GP
authors: Cioccia
authors: M
authors: M
authors: Chianelli
authors: P
authors: P
authors: Pozzilli
mesh_terms: D015415:Biomarkers; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006031:Glycosylation; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054839:Retinol-Binding Proteins, Plasma
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma