Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats.
Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow. Similar effects were not observed with administration of MAO A inhibitors. These observations suggest that activation of central dopamine and norepinephrine receptors, particularly in NACB, are involved in the control of gastric mucosal function.
Xing
L P
LP
Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Washington
J
J
Seaton
J
J
Kauffman
G
G
D000818:Animals; D003080:Cold Temperature; D004298:Dopamine / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000294:innervation / Q000502:physiology*; D008297:Male; D008995:Monoamine Oxidase / Q000502:physiology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D012039:Regional Blood Flow; D012149:Restraint, Physical
D008996:Monoamine Oxidase Inhibitors; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine