The additivity rule in the evaluation of health effects of combined exposure to solvents--does it hold?
On the basis of results obtained in experiments on animals exposed to mixtures of solvents the adequacy of additivity rule which is used in the evaluation of health effects of combined exposure to solvents is discussed. In the case of simultaneous exposure to mixture to toluen and xylene the modification of the additivity formula is proposed.
Sokal
J A
JA
Department of Toxicity Evaluation, Nofer Institute of Occupational Medicine, Lodz, Poland.
Korsak
Z
Z
D000818:Animals; D004781:Environmental Exposure; D008452:Maximum Allowable Concentration; D012997:Solvents; D014050:Toluene; D014992:Xylenes
D012997:Solvents; D014992:Xylenes; D014050:Toluene