Anti-HBc polymeric IgA antibodies in serum from acute hepatitis B patients.
Serum anti-HBc IgA antibodies can be demonstrated in acute hepatitis B patients. At first, they are mainly polymeric (p-IgA), whereas monomeric IgA (m-IgA) become detectable 3 months later. In most cases, anti-HBc IgA cannot be demonstrated after 6-12 months. From a diagnostic point of view, specific p-IgA can be regarded as a marker of active infection but, compared to IgM, their demonstration is more difficult.
Angeretti
A
A
Institute of Microbiology, Turin, Italy.
Ferrara
B
B
Biglino
A
A
Merlino
C
C
Negro Ponzi
A
A
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers; D003289:Convalescence; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology* / Q000302:isolation & purification; D011108:Polymers; D011863:Radioimmunoassay; D013997:Time Factors
D015415:Biomarkers; D006512:Hepatitis B Core Antigens; D007070:Immunoglobulin A; D011108:Polymers; C034639:polymeric IgA