Anti-HIV antibodies and other serological and immunological parameters among normal Haitians in Montreal.
A matched-pair, cross-sectional study of lymphocyte and serological parameters associated with acquired immune deficiency syndrome (AIDS) in 189 randomly chosen, ostensibly healthy adult Haitian immigrants residing in Montreal matched for sex, age (within 5 years), and neighborhood of residence to 189 non-Haitian (Caucasian) controls was done in 1983-1984. Three years later (1986-1987), 41 of the Haitian study subjects and 83 of the non-Haitian controls participated in a follow-up study centered on lymphocyte parameters. A significantly greater number of Haitians than controls had produced antibodies to Toxoplasma gondii. In addition, a greater percentage of the Haitians than the controls were also producing antibodies to two other opportunistic pathogens frequently encountered in AIDS, cytomegalovirus and hepatitis B virus, implying that the Haitians in general had had greater exposure to a variety of infectious agents than had the controls. A few study participants were producing antibodies against two viruses that are related to the human immunodeficiency virus-type 1 (HIV-1), the human T-cell lymphotropic viruses I and II (HTLV-I and -II). Two Haitians and one control were producing antibodies against HTLV-I. One study subject and four controls were HTLV-II seropositive. The most interesting and surprising finding was that four (2.1%) of the Haitian study subjects but none of the controls were seropositive for HIV-1. These individuals, two of whom were women and two men, were asymptomatic. Although their individual lymphocyte parameter values fell in the normal range, as a group they had statistically significantly lower average values for their lymphocyte parameters than did the HIV-seronegative Haitian study objects.(ABSTRACT TRUNCATED AT 250 WORDS)
Frappier-Davignon
L
L
Preventive Medicine and Epidemiology Research Center, Institut Armand-Frappier, Université du Québec, Laval, Canada.
Walker
M C
MC
Adrien
A
A
el Badraoui
L A
LA
Desrosiers
M
M
O'Shaughnessy
M V
MV
Affoyon
F
F
Dupuy
J M
JM
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies / Q000032:analysis*; D015528:HIV Seroprevalence; D006205:Haiti / Q000208:ethnology; D006510:Hepatitis B Antibodies / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D011792:Quebec; D011897:Random Allocation; D011795:Surveys and Questionnaires; D014122:Toxoplasma / Q000276:immunology
D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D015483:HIV Antibodies; D006510:Hepatitis B Antibodies