Debrisoquine hydroxylation and sulfamethazine acetylation in a Chinese population.
Both debrisoquine hydroxylation and sulfamethazine acetylation phenotypes were studied in the same native Chinese population. Debrisoquine hydroxylation status was determined by HPLC assay of debrisoquine metabolic ratio in urine after a single oral dose of 10 mg debrisoquine. Three poor metabolizers were found in 220 subjects (1.36%). One hundred and one subjects of this population previously debrisoquine phenotyped were also tested for acetylation phenotyping on a separate occasion. Their acetylation status were determined by HPLC assay of "% acetylation" after a single oral dose of 1 g sulfamethazine. Twenty (19.8%) slow acetylators were found. There were no significant association between the 2 metabolic pathways.
Xu
X M
XM
Institute of Clinical Pharmacology, Shanghai Medical University, China.
Jiang
W D
WD
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D002851:Chromatography, High Pressure Liquid; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism*
D013418:Sulfamethazine; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin