Management of low cardiac output syndrome after cardiac surgery using enoximone.
This case report describes the use of enoximone, a potent phosphodiesterase F-IV inhibitor with inotropic and vasodilator actions, to treat low output syndrome after cardiac surgery. The reduced cardiac output was unresponsive to a combination of inotropic drugs and intra-aortic balloon counterpulsation was contraindicated. Cardiac output was increased dramatically by enoximone, but systemic vascular resistance and perfusion pressure remained low until the addition of metaraminol.
White
D A
DA
Anaesthetic Department, Papworth Hospital, Cambridgeshire.
Latimer
R D
RD
Oduro
A
A
D000368:Aged; D002303:Cardiac Output, Low / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D004359:Drug Therapy, Combination; D017335:Enoximone; D006350:Heart Valve Prosthesis; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use; D008943:Mitral Valve; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy*
D002316:Cardiotonic Agents; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D008680:Metaraminol; D017335:Enoximone