[Interferon alpha-2a treatment of 26 patients with chronic non-A non-B hepatitis. Predictive factors of response].
The type and predicting factors of response to alpha interferon therapy have been studied in 26 patients with chronic non-A non-B hepatitis. Interferon was administered three times weekly during 6 months at a dose of 3 millions units/day. Eleven patients (42 percent) had serum alanine aminotransferase levels below 1.5 times the upper limit of normal range at the end of treatment. Only eight (31 percent) patients had persistent normalization of seric alanine aminotransferase value, 6 months after the end of the interferon treatment. The main factors involved in the response to therapy were age, apparent duration of the disease, and mode of contamination: patients who responded to interferon were younger, had a shorter duration of hepatitis and a parenterally transmitted disease.
Lunel-Fabiani
F
F
Service d'Hépato-Gastroentérologie, Hôpital de la Pitié-Salpêtrière, Paris.
Guivarch
P
P
Valla
D
D
Grippon
P
P
Marques
M A
MA
Huraux
J M
JM
Le Charpentier
Y
Y
Levy
V G
VG
Bousquet
O
O
Opolon
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D007370:Interferon Type I; D000410:Alanine Transaminase
Traitement par l'interféron alpha-2a de 26 cas d'hépatites chroniques non A-non B. Etude des facteurs prédictifs de réponse.