title: Primary skeletal Ewing's sarcoma in Down syndrome.
abstract: Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.
authors: Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
authors: J A
authors: JA
authors: Bridge
authors: J R
authors: JR
authors: Neff
authors: D A
authors: DA
authors: Borek
authors: D A
authors: DA
authors: Hackbarth
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002871:Chromosome Banding; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D012512:Sarcoma, Ewing / Q000150:complications* / Q000235:genetics / Q000473:pathology