Comparative study of cefuroxime axetil and procaine penicillin in the treatment of uncomplicated gonorrhoea.
A total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.
Kinghorn
G R
GR
Department of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield, UK.
Spencer
R C
RC
Smith
T K
TK
Woolley
P D
PD
Patel
R
R
Robinson
A J
AJ
D000284:Administration, Oral; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002584:Cervix Uteri / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010614:Pharynx / Q000382:microbiology; D011355:Prodrugs / Q000008:administration & dosage / Q000627:therapeutic use*; D012007:Rectum / Q000382:microbiology; D014521:Urethra / Q000382:microbiology
D011355:Prodrugs; D010402:Penicillin G Procaine; D002444:Cefuroxime; C040738:cefuroxime axetil