title: Expression of MHC class II antigens during Xenopus development.
abstract: Larval and adult forms of the amphibian Xenopus differ in their MHC class II expression. In tadpoles, class II epitopes can be detected by monoclonal antibodies only on B cells, macrophages (whatever their location), spleen reticulum, thymus epithelium, and the pharyngobuccal cavity. In contrast, all adult T cells express class II on their surface. The transitions in class II expression occur at metamorphosis and are accompanied by other changes. The skin is invaded by class II positive dendritic cells, and the skin glands differentiate and also express class II. The gut, which expressed class II in discrete areas of the embryonic tissue, becomes invaded with B cells, and its epithelium also becomes class II positive.
authors: Basel Institute for Immunology, Switzerland.
authors: L
authors: L
authors: Du Pasquier
authors: M F
authors: MF
authors: Flajnik
mesh_terms: D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D007107:Immune System / Q000254:growth & development; D007814:Larva / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014018:Tissue Distribution; D014981:Xenopus / Q000254:growth & development* / Q000276:immunology*; D014982:Xenopus laevis / Q000254:growth & development / Q000276:immunology
chemical_list: D000949:Histocompatibility Antigens Class II