Comparison of two hemodialysis membranes, polyacrylonitrile and cellulose acetate, on complement and coagulation systems.
Two hemodialysis membranes, polyacrilonitrile (AN 69) and cellulose acetate (CA), were compared for their effects on complement and hemostasis. Two groups of 5 patients, in dialysis for more than 5 years, were successively dialysed for 4 weeks periods with each type of membrane. We measured C3a (complement activation), platelets and beta-thromboglobulin (platelet activation), thrombin-antithrombin III complexes and fibrinopeptide A (coagulation activation), using C-Reactive Protein as a control for dilution effects. As previously shown, activation of complement was more important with CA than with AN 69 (p less than 0.01). In contrast, activation of coagulation (increase in fibrinopeptide A and thrombin-antithrombin III complexes) was more pronounced with AN 69 than with CA. This study emphasizes the need to consider different biological systems when the bioincompatibility of a hemodialysis membrane is evaluated.
Moll
S
S
Department of Medicine, University Cantonal Hospital, Geneva, Switzerland.
De Moerloose
P
P
Reber
G
G
Schifferli
J
J
Leski
M
M
D000180:Acrylic Resins / Q000009:adverse effects*; D000181:Acrylonitrile / Q000009:adverse effects* / Q000031:analogs & derivatives; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism; D001672:Biocompatible Materials; D001777:Blood Coagulation / Q000187:drug effects*; D002482:Cellulose / Q000009:adverse effects / Q000031:analogs & derivatives*; D003167:Complement Activation / Q000187:drug effects*; D015926:Complement C3a / Q000378:metabolism; D005260:Female; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects*; D010447:Peptide Hydrolases / Q000378:metabolism; D010976:Platelet Count / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation; D001620:beta-Thromboglobulin / Q000378:metabolism
D000180:Acrylic Resins; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009570:Nitriles; C046193:antithrombin III-protease complex; D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; C005062:acetylcellulose; C016892:AN-69; D015926:Complement C3a; D000990:Antithrombin III; D002482:Cellulose; D010447:Peptide Hydrolases; D000181:Acrylonitrile