The influence of different combined oral contraceptives on the prevalence and severity of dysmenorrhea.
The influence of different oral contraceptives (OC) on the prevalence and severity of dysmenorrhea was investigated longitudinally (from age 19 to 24 years) in a representative sample of young women from an urban Swedish population. The women were grouped according to the type of OC used at the time of assessment: monophasic OC with low gestagen activity; progestogen-dominated monophasic OC; triphasic OC; neither OC nor an intrauterine device (IUD). At the age of 19 years, the severity of dysmenorrhea was lower in users of monophasic OCs with low gestagen activity (p less than 0.05) and users of progestogen-dominated monophasic OCs (p less than 0.001) compared to women who used neither OC nor an IUD. At 24 years of age, the severity of dysmenorrhea was lower in users of monophasic OCs with low gestagen activity (p less than 0.001), users of progestogen-dominated monophasic OCs (p less than 0.001) and users of triphasic OCs (p less than 0.001), compared to women who used neither OC nor an IUD. The severity of dysmenorrhea in women who did not use an OC or IUD when 19 years old was reduced in the same women who used OCs when 24 years old, compared (p less than 0.001) to women who still used neither an OC nor an IUD. There were no significant differences in the prevalence and severity of dysmenorrhea between the users of monophasic OCs, irrespective of progestagen activity, and users of triphasic preparations.
Milsom
I
I
Department of Obstetrics and Gynecology, University of Göteborg, East Hospital, Sweden.
Sundell
G
G
Andersch
B
B
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy*; D004997:Ethinyl Estradiol; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016912:Levonorgestrel; D008234:Lynestrenol / Q000627:therapeutic use; D008656:Mestranol / Q000627:therapeutic use; D009640:Norethindrone / Q000627:therapeutic use; D009644:Norgestrel / Q000627:therapeutic use
D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel; D008656:Mestranol; D008234:Lynestrenol; D009640:Norethindrone