[Differences in the renal handling of sodium according to the response to captopril].
We study the modifications of sodium tubular resorption, measured by lithium clearance after a single dosage of sublingual captopril, administered to 24 patients afflicted with nonfiltration after captopril produced an increase of proximal resorption of sodium, compensated by minor distal resorption, keeping a constant natriuresis. The different effects of captopril on blood pressure create 2 groups: a) patients who showed a decrease of blood pressure (n = 14), where a fall of distal resorption of sodium simultaneous with an increase of fractional sodium excretion was registered, and b) patients who did not experience changes in blood pressure nor changes after tubular function tests.
Muñiz Grijalvo
O
O
Unidad de Hipertensión, Hospital Virgen del Rocío, Sevilla.
Carneado de la Fuente
J
J
Villar Ortiz
J
J
Lapetra Peralta
J
J
Miranda Guisado
M
M
Martín Sanz
V
V
Molina Miró
J
J
D000042:Absorption; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007677:Kidney Function Tests / Q000379:methods; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism; D008094:Lithium; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism*
D016651:Lithium Carbonate; D008094:Lithium; D002216:Captopril; D012964:Sodium
Diferencias en el manejo renal de sodio según la respuesta al captopril.