Behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in monkeys.
Subcutaneous injections of a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in monkeys induced distinct behavioural changes characterized by head weaving, hindlimb extension and upper limb fluttering. The effects were dose-dependent and were similar to the 5-HT syndrome induced in rats by 8-OH-DPAT. The 5-HT receptor antagonist, metergoline, attenuated the behavioural syndrome seen in response to 8-OH-DPAT. These results suggest that 8-OH-DPAT induces a 5-HT1A receptor-mediated behavioural syndrome in monkeys as well as in rodents.
Mizuta
E
E
Department of Neurology, Utano National Hospital, Kyoto, Japan.
Yamaguchi
M
M
Kuno
S
S
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D008711:Metergoline; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin