Surgical analgesia for knee arthroscopy with epidural lignocaine and sufentanil--effect of varying sufentanil doses.
In a double blind trial the additional analgesic effect of the combination of epidural lignocaine 2% + epinephrine 1/200,000 with varying epidural Sufentanil doses was studied per- and postoperatively in patients undergoing arthroscopy of the knee. Fifty patients were randomly divided into five groups. They received epidural lignocaine 2% + epinephrine 1/200,000 in addition with respectively 0, 20, 30, 40 or 50 micrograms Sufentanil. There was no additional surgical analgesia when Sufentanil was added. On the other hand, at 40 and 50 micrograms of Sufentanil significantly more patients demonstrated respiratory depression and pronounced sedation during surgery as compared to lignocaine alone. Patients in these groups had better postoperative analgesia. In addition nausea, vomiting and pruritus were seen in some patients at all doses of Sufentanil.
Reynvoet
M
M
Department of Anesthesiology, St. Maartensziekenhuis, Burg. Vercruysselaan, Kortrijk, Belgium.
Dionys
J
J
Vermaut
G
G
Van Aken
H
H
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000328:Adult; D015360:Analgesia, Epidural; D000700:Analgesics / Q000008:administration & dosage*; D000767:Anesthesia, Epidural; D001182:Arthroscopy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D017409:Sufentanil
D000759:Adjuvants, Anesthesia; D000700:Analgesics; D008012:Lidocaine; D017409:Sufentanil; D005283:Fentanyl