[Dehydroepiandrosterone sulfate (DHEAS) concentration changes in clomiphene therapy?].
Plasma DHEAS levels were followed in 10 anovulatory patients, treated with 50 mg clomiphene citrate from the 5th to the 9th day of menstruation as well as 6 ovulatory women, who were taken as controls. A serum progesterone level of 13 nmol/l or more in the luteal phase was found in both, the treatment and the control group. This was considered to be a strong indication, that ovulation had occurred. A significant preovulatory increase in DHEAS levels was found neither in the treatment nor in the control group. A negative influence of DHEAS on the ripening of the follicles due to a single dose of 50 mg of clomiphene during 5 days of menstruation seems unlikely.
van der Weiden
R M
RM
Frauenklinik und Medizinisch-Diagnostisches Laboratorium, Rotterdam, Niederlande.
Hage
J C
JC
Helbing
A R
AR
Jansen
J W
JW
D000328:Adult; D000858:Anovulation / Q000097:blood / Q000188:drug therapy*; D002996:Clomiphene / Q000008:administration & dosage*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D002996:Clomiphene; D003687:Dehydroepiandrosterone; D011374:Progesterone; D019314:Dehydroepiandrosterone Sulfate
Dehydroepiandrosteronsulfat-(DHEAS-)Konzentrations-Anderungen während Clomiphen-Therapie?