title: Regional cerebral blood flow after a localized cerebral contusion in pigs.
abstract: Regional cerebral blood flow (rCBF) in anaesthetized pigs is investigated before and after an induced focal cerebral contusion. Mean intracranial pressure increased for a short period following the contusion and reduced perfusion pressure to 60% of control pressure. Forty five minutes later the mean intracranial pressure was still high and different from the control values. Global flow and cerebral production of CO2 increased concomitantly. In the cortical region where the contusion was visible macroscopically the rCBF diminished from 36.5 to 29.1 ml/min/100 g. In the rest of the grey matter the rCBF raised after the contusion with an increase away from the centre of the lesion. CBF of cortical grey matter in the region symmetrically to the contusion increased significantly more than in the traumatized hemisphere. White matter rCBF changed least in the region underlying the contusion, while an increase was observed away from the contusion and on the opposite side of the brain. The correlation between tension of CO2 in arterial blood and regional cerebral blood flow disappeared in the region of the contusion. The correlation between global metabolism and regional cerebral blood flow disappeared after the contusion in all regions. Local flow modulating factors influencing flow in the region of macroscopically visible injury has influence abating with distance from the centre of the injury together with a possible neuronally transmitted drive on flow in the opposite hemisphere.
authors: Department of Neurosurgery, Aarhus Kommunehospital, Denmark.
authors: F F
authors: FF
authors: Madsen
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D001924:Brain Concussion / Q000503:physiopathology*; D001931:Brain Mapping; D002245:Carbon Dioxide / Q000097:blood; D004292:Dominance, Cerebral / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D007427:Intracranial Pressure / Q000502:physiology; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow / Q000502:physiology; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen