Metabolic dynamics in the human red cell. Part III--Metabolic reaction rates.
The kinetics of the enzymatic reaction and transport rates that constitute the main metabolic pathways of the red cell metabolism are described. The red cell metabolic model consists of 33 dynamic mass balances that contain 41 enzymatic reaction rate laws and transmembrane processes. Our goal here is two-fold: the development of rate expressions for the individual biochemical reactions of the integrated red cell metabolism, and order of magnitudes estimates to gauge their dynamic properties in terms of response times and action scales of substrates, products and regulators.
Joshi
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Department of Chemical Engineering, University of Michigan, Ann Arbor 48109-2136.
Palsson
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BO
D000249:Adenosine Monophosphate / Q000378:metabolism; D001693:Biological Transport, Active; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010427:Pentose Phosphate Pathway / Q000502:physiology
D000249:Adenosine Monophosphate; D017301:Ca(2+) Mg(2+)-ATPase