title: Serum neopterin levels following intravenous endotoxin administration to normal humans.
abstract: Endotoxin was administered intravenously to five normal subjects. Measurement of serum neopterin levels demonstrated no significant change from baseline during the first 6 h after endotoxin administration, but were elevated two to four-fold at 24 h. In the three subjects in whom it was measured, a two-fold rise of the mean serum neopterin levels persisted at 48 h. The acute inflammatory events initiated by endotoxin administration to normal humans result in a delayed, but sustained, rise in serum neopterin levels which persists well after the acute phase response has subsided.
authors: National Eye Institute, National Institutes of Health, Bethesda, Maryland.
authors: J N
authors: JN
authors: Bloom
authors: A F
authors: AF
authors: Suffredini
authors: J E
authors: JE
authors: Parrillo
authors: A C
authors: AC
authors: Palestine
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000139:chemically induced; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D019798:Neopterin; D012772:Shock, Septic / Q000097:blood; D013997:Time Factors
chemical_list: D004731:Endotoxins; D001708:Biopterins; D019798:Neopterin