The comparison of early follicular and midluteal administration of long-acting gonadotropin-releasing hormone agonist.
Long-acting GnRH-a (D-Trp6 microcapsules, 3.2 mg) was intramuscularly injected, either in early follicular phase (group A) or midluteal phase (group B). Two hundred sixteen cycles were randomly allocated. Ovarian suppression was significantly more prompt in group B. Follicle cysts were diagnosed in 19% and 16% of groups A and B, respectively; their appearance and regression were significantly more rapid in group B cycles. More ampules of human menopausal gonadotropin were needed in group B. The number of oocytes retrieved was not significantly different between the groups. However, in group A more mature oocytes and more embryos with good morphology were achieved in the patients. Cancellation rate was 2.8% in groups A and B. Pregnancy rate and outcome were similar in both groups.
Ron-El
R
R
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Tel Aviv University, Zerifin, Israel.
Herman
A
A
Golan
A
A
van der Ven
H
H
Caspi
E
E
Diedrich
K
K
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008183:Luteal Phase; D008186:Luteolytic Agents; D010048:Ovarian Cysts / Q000473:pathology; D006080:Ovarian Follicle; D011247:Pregnancy; D011256:Pregnancy Outcome; D017329:Triptorelin Pamoate
D006063:Chorionic Gonadotropin; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone