[Treatment of mesothelioma with interferon gamma and interleukin 2].
Interferon gamma was first used in 10 patients with mesothelioma in doses of 20 x 10(6) IU administered intrapleurally twice a week for 2 months without success, then in 25 patients (12 in stage I, 11 in stage II or IV) in doses of 40 x 10(6) IU. Out of 20 assessable patients, 4 showed complete response (CR) confirmed at thoracoscopy or thoracotomy; 1 stage I patient and 1 stage II patients showed partial response (PR). Interleukin 2 was administered by continuous intrapleural infusion in increasing dosage. Out of 3 stage I patients, 1 showed CR and 2 showed PR; 4 partial responses were observed in 11 stage II, III or IV patients. The 5/15 CR rate at stage I is exceptional in mesothelioma. In stage II patients the effectiveness and modalities of treatment require further investigations.
Boutin
C
C
Hôpital de la Conception, Marseille.
Viallat
J R
JR
Astoul
P
P
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D010994:Pleura; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D013906:Thoracoscopy
D007376:Interleukin-2; D007371:Interferon-gamma
Le traitement des mésothéliomes par interféron gamma et interleukin 2.