On the changes in peripheral red cells in mice exposed to vinyl chloride monomer.
The diseases known as the Vinyl Chloride Monomer (VCM) Syndrome include hepatic angiosarcoma, acroosteolysis and Raynaud's phenomenon. These, however, are known to be clinically recognizable from several to over 10 years after the actual exposure to VCM. By fluorescence microscopy the authors examined smeared samples of peripheral blood obtained from vinyl chloride workers, and observed the existence of basophilic stippled erythrocytes (BSE). In this paper, we report the changes of peripheral red cells during VCM exposure tests on mice. These changes in the peripheral blood could be observed as early as 24 hours after the start of the VCM exposure at higher concentrations, and in 72 hours even at comparatively lower VCM levels of 30 to 40 ppm. The tests have also confirmed that the rate of emergence of BSE differs according to the level of VCM and to the duration of VCM exposure.
Kudo
Y Y
YY
Department of Hygiene, St. Marianna University School of Medicine, Kawasaki, Japan.
Yamada
S
S
Nakamura
I
I
Sakaguchi
T
T
Sakaguchi
S
S
Ohe
T
T
Kamagata
H
H
Naito
A
A
Nakazawa
S
S
D000818:Animals; D001273:Atmosphere Exposure Chambers; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008856:Microscopy, Fluorescence; D012156:Reticulocytes / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D014752:Vinyl Chloride / Q000633:toxicity*
D014752:Vinyl Chloride