Prodromal symptoms in primary major depressive disorder.
Prodromal symptomatology was investigated, by means of a modified version of Paykel's Clinical Interview for Depression, in 15 outpatients at their first episode of primary major depressive disorder. Compared to normals, generalized anxiety and irritability were significantly more frequent. Impaired work and interests, fatigue, initial and delayed insomnia were also reported. Four patients who relapsed upon discontinuation of antidepressant treatment displayed the same prodromal symptomatology as in the initial episode.
Fava
G A
GA
Department of Psychology, University of Bologna, Italy.
Grandi
S
S
Canestrari
R
R
Molnar
G
G
D000328:Adult; D001008:Anxiety Disorders / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D007508:Irritable Mood; D008297:Male; D008875:Middle Aged; D009042:Motivation; D011569:Psychiatric Status Rating Scales; D012008:Recurrence