Increased levels of beta-human atrial natriuretic peptide-like immunoreactivity in chronically overloaded atrial tissue.
The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase in beta-human ANP-LI (beta-hANP-LI). Both total ANP-LI and beta-hANP-LI levels were associated with the presence of atrial fibrillation and with increased atrial pressure. Plasma beta-hANP-LI levels were also increased in mitral disease. These results suggest that human atrium with hemodynamic overloads is characterized by increased tissue levels of ANP and by a shift to the beta-hANP form.
Naruse
M
M
Department of Medicine, Tokyo Women's Medical College, Japan.
Hiroe
M
M
Naruse
K
K
Nagata
M
M
Ohno
H
H
Hashimoto
A
A
Koyanagi
H
H
Sekiguchi
M
M
Demura
H
H
Hirosawa
K
K
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000276:immunology / Q000378:metabolism*; D001794:Blood Pressure; D002908:Chronic Disease; D006325:Heart Atria / Q000378:metabolism / Q000503:physiopathology; D006331:Heart Diseases / Q000378:metabolism* / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D015394:Molecular Structure; D009206:Myocardium / Q000378:metabolism*; D011863:Radioimmunoassay
D009320:Atrial Natriuretic Factor