title: Clinical and parasitologic aspects of cryptosporidiosis in nonhuman primates.
abstract: Eighty-one cases of acute cryptosporidiosis were diagnosed among 157 (52%) infant primates, predominantly Macaca nemestrina, housed in the nursery unit of the Washington Regional Primate Research Center. The mean age at onset of oocyst passage was 38 +/- 25 days. The outbreak was confined to the nursery and no cases were detected among juvenile or adult primates housed in other rooms within the colony. All but one animal manifested symptoms of enteric infection, including severe diarrhea and dehydration. Infected animals excreted oocysts for a mean of 36 days (range 7-78 days). No reinfections occurred. Cryptosporidium was the second most common enteric pathogen detected in the population, after Campylobacter jejuni. The risk of infection was related to the length of time the animal was housed in the nursery and to social interaction with other monkeys. These findings are relevant to the understanding of the epidemiology of cryptosporidiosis among human infants and children in environments with close social interactions and minimal learned personal hygiene practices.
authors: Division of Infectious Disease, Seattle Veteran's Administration Medical Center, WA 98108.
authors: R A
authors: RA
authors: Miller
authors: M A
authors: MA
authors: Bronsdon
authors: L
authors: L
authors: Kuller
authors: W R
authors: WR
authors: Morton
mesh_terms: D000818:Animals; D002167:Campylobacter / Q000302:isolation & purification; D003457:Cryptosporidiosis / Q000453:epidemiology / Q000469:parasitology*; D003967:Diarrhea / Q000469:parasitology / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D008251:Macaca; D008252:Macaca fascicularis; D008254:Macaca nemestrina; D008992:Monkey Diseases / Q000469:parasitology*; D010215:Papio; D012760:Shigella / Q000302:isolation & purification; D013997:Time Factors