[New route of 2-N-(carboxypropylamino)-2-deoxy-D-glucopyranose synthesis].
A new route to 2-N-(carboxypropylamino)-2-deoxy-D-glucopyranose synthesis is reported, involving the Schiff-base derivative of beta-D-glucosamine with benzyl 4-oxobutyrate. Improvement in the synthesis of benzyl-4-oxobutyrate is also described. Biological compounds action was investigated by evaluating sedative and dopaminergic activities on male mice.
Couffignal
R
R
Laboratoire de Chimie des Médiateurs Moléculaires, Université Pierre et Marie Curie, Paris.
Dardoize
F
F
Goasdoue
C
C
Goasdoue
N
N
Laborit
H M
HM
Topall
G
G
D000818:Animals; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D018492:Dopamine Antagonists; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives*
D018492:Dopamine Antagonists; D006993:Hypnotics and Sedatives; C071453:2-N-(carboxypropylamino)-2-deoxyglucopyranose; D005680:gamma-Aminobutyric Acid; D003847:Deoxyglucose
Nouvelle voie de synthèse de 2-N-(carboxypropylamino)-2-désoxy-D-glucopyranose.