title: Controlled comparison of buspirone and oxazepam in generalized anxiety.
abstract: The anxiolytic activity, the tolerance, and the withdrawal symptoms of buspirone and oxazepam were compared in two groups of 14 and 12 outpatients, respectively, suffering from generalized anxiety in a double-blind study with random allocation of patients. The 6-week active period was preceded and followed by 1 and 2 weeks on placebo, respectively. Clinical assessments were performed before and after the predrug placebo period and every 2 weeks thereafter and included Hamilton anxiety and depression scales and AMDP anxiety subscale. The initial daily dose was 15 mg buspirone or 45 mg oxazepam in 3 intakes and the mean final daily doses were 22.2 and 55.8 mg, respectively. Results showed a slower anxiolytic activity of buspirone compared to oxazepam with less improvement after 2 weeks of treatment. The rebound anxiety following abrupt discontinuation of the drug and the level of side effects did not significantly differ between the two compounds.
authors: Psychiatric Unit, Centre Hospitalier Universitaire de Liège, Belgium.
authors: M
authors: M
authors: Ansseau
authors: P
authors: P
authors: Papart
authors: M A
authors: MA
authors: Gérard
authors: R
authors: R
authors: von Frenckell
authors: G
authors: G
authors: Franck
mesh_terms: D000328:Adult; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D002065:Buspirone / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010076:Oxazepam / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D013375:Substance Withdrawal Syndrome / Q000523:psychology
chemical_list: D010076:Oxazepam; D002065:Buspirone