title: MR imaging of infectious spondylitis.
abstract: MR images of 14 patients with pyogenic and three patients with tuberculous infectious spondylitis were studied to develop criteria for diagnosis. T1-weighted scans, 800/20 (TR/TE), were obtained in 17 patients and T2-weighted scans, greater than 2000/30,80, were obtained in 14. In seven patients, T2*-weighted scans (gradient-recalled acquisition into steady state, 25/15/5-7 degrees [TR/TE/flip angle]) and short-T1 inversion-recovery scans (STIR), 1400/150/40 (TR/TI/TE), as well as fat and water images (using a suppression technique), were obtained. Unenhanced and gadopentetate-dimeglumine-enhanced scans were obtained in four patients. In all but two patients with pyogenic infectious spondylitis, the T1-weighted sagittal scan showed characteristic findings: narrowed disk space, low signal intensity in the marrow of at least two adjacent vertebrae, subligamentous or epidural soft-tissue masses, and erosion of cortical bone. In one patient the T1-weighted scan was normal and abnormalities could be detected only on the T2-weighted scan. The remaining patient had abnormal marrow signal on the T1-weighted scan but only in one vertebral body. On T2-weighted images the major findings were a narrowed disk space with variable signal changes, abnormal high signal in marrow of at least two adjacent vertebrae, high-signal subligamentous or epidural masses, and cortical bone erosion. The findings in the three patients with tuberculous spondylitis included areas of increased and decreased signal intensity in vertebrae on T1-weighted images. Disk spaces were relatively spared given the extent of disease. Extraosseous soft-tissue components could be large. Bone erosion was best seen on the first echo of a T2-weighted sequence and on a water image; the latter was most reliable since it had no chemical-shift artifact. The use of gadopentetate dimeglumine could obscure or clarify MR findings, depending on the situation. T1- and T2-weighted MR images should be obtained for assessment of infectious spondylitis. STIR scans are particularly helpful. Fat images can be useful in subtle presentations, since they are very sensitive to marrow replacement, and gadopentetate dimeglumine may be helpful for epidural delineation of disease.
authors: Department of Diagnostic Radiology and Nuclear Medicine, Stanford University School of Medicine, CA 94305-5105.
authors: A
authors: A
authors: Thrush
authors: D
authors: D
authors: Enzmann
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013131:Spine / Q000473:pathology; D013166:Spondylitis / Q000175:diagnosis*; D014399:Tuberculosis, Spinal / Q000175:diagnosis