Effects of mianserin on human sleep.
Sleep EEG and nocturnal penile tumescence (NPT) were investigated in 6 healthy men during placebo and mianserin administration and after mianserin withdrawal. The results were assessed in a historical comparison with those previously obtained with clomipramine. With mianserin, REM sleep was suppressed slightly. However, the suppressive effect of mianserin on REM sleep--based on the historical comparison--was significantly weaker than that of clomipramine throughout all the drug nights. Accordingly, a rebound increase in REM sleep was not observed after withdrawal. Less suppressive effects on NPT and disturbance of sexual function with mianserin than with clomipramine were observed. We suggest that a correlation between the prolonging effect on REM latency and the clinical antidepressant effect is limited to some antidepressants.
Maeda
Y
Y
Department of Neuropsychiatry, School of Medicine, Kanazawa University, Japan.
Hayashi
T
T
Furuta
H
H
Kim
Y
Y
Morikawa
K
K
Ishiguro
N
N
Ueno
K
K
Sano
J
J
Yamaguchi
N
N
D000293:Adolescent; D000328:Adult; D002997:Clomipramine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects*
D008803:Mianserin; D002997:Clomipramine