[Prevention of influenza A. Effectiveness and tolerance of rimantadine hydrochloride].
The prophylactic effectiveness of rimantadine hydrochloride (RH) during an outbreak of influenza A was evaluated in a double-blind study versus placebo (P). After identification of 111 homes with one affected member, 301 household contacts were enrolled and given either RH (151 contacts from 56 households) or a placebo (150 contacts from 55 households). Each treatment was given for ten days. Overall, at least one contact developed influenza in 8 of the 56 RH group households and 19 of the 55 placebo group households (p = 0.013). Numbers of contacts who developed influenza were 8/151 in the RH group and 26/150 in the placebo group. When only the 49 homes where influenza was confirmed by virological studies were considered, these numbers were 4/28 in the RH group and 10/21 in the placebo group (p = 0.011). Adverse effects were seen in 18 of the 151 subjects given RH (11.9 per cent) and 6 of the 150 subjects given the placebo (4 per cent). RH appeared as an effective prophylactic agent in a confirmed influenza A outbreak and was satisfactorily tolerated.
Bricaire
F
F
Service des Maladies infectieuses et tropicales, Hôpital Bichat-Claude-Bernard, Paris.
Hannoun
C
C
Boissel
J P
JP
D000218:Adamantane / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D005602:France; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D010919:Placebos; D011292:Premedication; D012299:Rimantadine / Q000009:adverse effects / Q000627:therapeutic use*
D010919:Placebos; D012299:Rimantadine; D000218:Adamantane
Prévention de la grippe A. Efficacité et tolérance du chlorhydrate de rimantadine.