[Enhancement of cell growth by human interferons].
The effects of human interferons (HuIFN) on the human osteosarcoma cells were examined. HuIFN-alpha, -beta and -gamma enhanced dose-dependently the cell growth. There was no difference in the degree of the enhancement of the cell growth among HuIFN-alpha, -beta and -gamma. The higher the cell density was, the lower the degree of the enhancement of the cell growth. When HuIFN-gamma was neutralized with anti-HuIFN-gamma, the enhancement of cell growth was not found.
Yamaguchi
N
N
Département de Microbiologie, Université Médicale de la Préfecture de Kyoto, Japan.
Tong
L J
LJ
Yamamura
Y
Y
Otsuka
G
G
Tamura
Y
Y
Kita
M
M
Imanishi
J
J
D000293:Adolescent; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D012516:Osteosarcoma / Q000473:pathology; D013268:Stimulation, Chemical; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007370:Interferon Type I; D007371:Interferon-gamma
Accélération de la croissance cellulaire par les interférons humains.