Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 microM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.
Quasthoff
S
S
Physiologisches Institut, Technischen Universität München, F.R.G.
Franke
C
C
Hatt
H
H
Richter-Turtur
M
M
D000255:Adenosine Triphosphate / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D004095:Dihydropyridines / Q000494:pharmacology*; D004594:Electrophysiology; D005905:Glyburide / Q000494:pharmacology; D006801:Humans; D009132:Muscles / Q000378:metabolism*; D010847:Picolines / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D011714:Pyrans / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*
D001578:Benzopyrans; D004095:Dihydropyridines; D010847:Picolines; D015221:Potassium Channels; D011714:Pyrans; D011758:Pyrroles; D019806:Cromakalim; C061043:aprikalim; C061050:bimakalim; D000255:Adenosine Triphosphate; D005905:Glyburide