[The determination of specific IgE in allergy diagnosis. The clinical significance of specific IgE in drug allergies].
IgE-mediated allergic reactions to drugs may be diagnosed on the basis of anamnestic criteria, clinico-pathological manifestations as well as by the measurement of allergen-specific IgE. The concordance of these diagnostic procedures was investigated in 50 patients with a history of sensitivity to penicillin (12), sulphamethoxazole (9) or both (14), aspirin (2) and pyrazolones (13). All subjects displayed chronic urticaria/angioedema syndrome. Optimal concordance values were observed for penicillin and sulphamethoxazole, while no specific IgE were detected in the ASA-sensitive group. False positive results were noted in pyrazolone-sensitive patients with high total IgE levels. Based on these results, serological methods that detect drug-specific IgE may be carefully used as complementary diagnostic procedure only in those patients in whom an adverse reaction to antibiotics is suspected.
Spinozzi
F
F
Istituto di Clinica Medica I, Università degli Studi di Perugia.
Cimignoli
E
E
Gerli
R
R
Broccucci
L
L
Berchicci
P
P
Bertotto
A
A
Del Favero
A
A
D000918:Antibody Specificity; D001241:Aspirin / Q000009:adverse effects / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D010406:Penicillins / Q000009:adverse effects / Q000276:immunology; D011720:Pyrazoles / Q000009:adverse effects / Q000276:immunology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000276:immunology
D010406:Penicillins; D011720:Pyrazoles; D007073:Immunoglobulin E; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001241:Aspirin
Il dosaggio delle IgE-specifiche nella diagnostica allergica. Significato clinico delle IgE-specifiche nelle allergie a farmaci.