The tenuous relationship between atriopeptin and sodium excretion.
The data reviewed here illustrate that circulating levels of atriopeptin between 3- and 12-fold above normal produce only modest and slowly developing renal responses. Left atrial distension produces a diuretic and natriuretic response that appears to be mediated by cardiac reflexes, not by the increase in circulating levels of atriopeptin. Similarly the natriuretic response to intravascular volume expansion occurs normally even if circulating atriopeptin is caused to decline during the volume expansion. Finally, plasma atriopeptin levels do not contribute to postprandial natriuresis, because circulating levels do not increase acutely in response to eating a meal containing sodium. It seems unlikely, therefore, that atriopeptin exerts a substantial effect on the regulation of sodium excretion under normal physiological conditions.
Goetz
K L
KL
Division of Experimental Medicine, St. Luke's Hospital and Foundation, Kansas City, Missouri 64111-9000.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D006801:Humans; D012964:Sodium / Q000652:urine*
D009320:Atrial Natriuretic Factor; D012964:Sodium