Low-grade primary B-cell lymphoma of the lung. An immunohistochemical, molecular, and cytogenetic study of a single case.
A case of primary low-grade pulmonary lymphoma is described. The histologic features conformed to those laid down by Saltzstein for a diagnosis of "pseudolymphoma." However, the immunocytochemical and molecular investigations confirmed the tumor to be a low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Cytogenetic studies revealed an abnormal karyotype with a translocation t(1;14). This is the first reported case of an abnormal karyotype in a case of a lymphoma of MALT.
Wotherspoon
A C
AC
Department of Histopathology, University College and Middlesex School of Medicine, London, United Kingdom.
Soosay
G N
GN
Diss
T C
TC
Isaacson
P G
PG
D000943:Antigens, Differentiation / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D007150:Immunohistochemistry; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D015260:Neprilysin; D011951:Receptors, Complement / Q000378:metabolism; D017464:Receptors, Complement 3d; D014178:Translocation, Genetic / Q000235:genetics
D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D004273:DNA, Neoplasm; D007146:Immunoglobulin lambda-Chains; D011951:Receptors, Complement; D017464:Receptors, Complement 3d; D015260:Neprilysin