title: Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat.
abstract: Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg morphine pellet). Of the 12 withdrawal signs scored, the only significant changes observed after ibogaine (compared with vehicle control) was a decrease in grooming (10 mg kg-1) and an increase in teeth chatter (5 mg kg-1). In spite of ibogaine's apparent interaction with several neurotransmitter receptor systems, it does not alleviate opioid withdrawal in this animal model at non-tremorigenic (5 and 10 mg kg-1) or tremorigenic (20 and 40 mg kg-1) doses.
authors: Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
authors: L G
authors: LG
authors: Sharpe
authors: J H
authors: JH
authors: Jaffe
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D009021:Morphine Dependence; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*; D014202:Tremor / Q000139:chemically induced
chemical_list: D009270:Naloxone; D007050:Ibogaine