Effects of maternal exposure to trioxane on postnatal development in rats.
Female rats were given by gavage every other day from days 2 to 20 of gestation an aqueous solution of trioxane at daily doses equal to 0.025; 0.075 and 0.15 LD50 (0.19: 0.58 and 1.16 g/kg). Maternal exposure to trioxane at the highest dose resulted in death of most neonates a few days after birth. Viability and postnatal growth of the offspring of dams that were given 0.19 and 0.58 g/kg were not affected. Transitional depression of exploratory locomotor activity in female offspring and a decrease of active avoidance acquisition were observed in adult male and female offspring from the 0.58 g/kg group, whereas a dose of 0.19 g trioxane /kg did not affect the behavioral performance of progeny.
Sitarek
K
K
Department of Occupational Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Barański
B
B
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D006128:Growth / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008431:Maternal-Fetal Exchange; D009043:Motor Activity / Q000187:drug effects; D009153:Mutagens / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D006571:Heterocyclic Compounds; D009153:Mutagens; C011374:s-trioxane