[Immunoregulatory effects of monomer T4 from Tripterygium wilfordii hook. I. Immunoregulatory effects of T4 on NK activity of mouse splenocytes].
Effects of monomer T4 on NK activity of mouse splenocytes were determined both in vitro and in vivo by means of a classical I-UdR release assay. The results showed that monomer T4 exhibited dose-dependent double-regulatory inhibiting enhancing effects, ie, T4 of low dosage enhanced the percentage of NK cytotoxicity and LU numbers, while a high dosage showed dose-dependent inhibition. The double-regulatory effects of monomer T4 might be important for evaluation of the therapeutic effects of Tripterygium wilfordii Hook in future clinical practice.
Lou
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Institute of Dermatology, Nanjing.
Xu
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W
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D051379:Mice; D029757:Tripterygium
D004365:Drugs, Chinese Herbal