Effects of various nitrates on pulmonary wedge pressure in acute myocardial infarction.
122 patients with acute myocardial infarction showing a positive antianginal response to nitroglycerin were examined. With the patients under continuous haemodynamic control including pulmonary artery catheterization the circulatory response to various nitrates administered orally, sublingually or transdermally was investigated. A safe time interval was determined for each drug to ensure stability of the attained wedge pressure reduction.
Roshchin
S I
SI
Department of Internal Diseases, M. Gorky Medical Institute, Donetsk, USSR.
Berezov
V M
VM
Varlamov
A M
AM
Boch
V K
VK
Roshchina
G N
GN
Verzilov
S N
SN
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000286:Administration, Sublingual; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D009566:Nitrates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005996:Nitroglycerin / Q000494:pharmacology / Q000627:therapeutic use; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D009566:Nitrates; D014665:Vasodilator Agents; D005996:Nitroglycerin