[Induced cell fusion in the contact zone of cells with affected and unaffected surfaces. I].
The change in capacity of the cell fusion stimulated with polyethylenglycol is applied as a criterion of accumulation of noxiously transformed properties of cell surfaces. Similar changes are induced with substances employed as follows: chinuclidyl benzilate, atropiniumsulphate, tetrahydroaminacridine. The dynamics of releasing these substances is also tracked by dynamics of fusions capacity. In the area of contact of cells both noxiously influenced and uninfluenced, the decrease in capacity of fusions is also observed. At least a part of toxical substance is so released outside the cells. The former is then linked to the surfaces of unfluenced cells. This is an example of transfer of substance linked with the cell surface which is concerned.
Hroch
M
M
Katedra Biologie, Anatomie, Histologie a Embryologie LF UK, Hradec Králové.
D001285:Atropine / Q000494:pharmacology; D002459:Cell Fusion / Q000187:drug effects*; D002462:Cell Membrane / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology; D011813:Quinuclidinyl Benzilate / Q000494:pharmacology; D013619:Tacrine / Q000494:pharmacology
D011092:Polyethylene Glycols; D013619:Tacrine; D011813:Quinuclidinyl Benzilate; D001285:Atropine
Indukovaná bunĕcná fúze v zónĕ kontaktu bunĕk s ovlivnĕnými a neovlivnĕnými povrchy I.