Electrocardiographic changes induced by levamisole hydrochloride in the guinea-pig.
The effects of various i.v. doses of levamisole on the ECG of the anaesthetized guinea-pigs were determined. At 6 mg/kg there were no changes in the heart rate, P-R and Q-T intervals and no cardiotoxic effects were observed. At 10 and 20 mg/kg these parameters were affected little but cardiotoxic effects, mainly ventricular extrasystoles lasting from a few seconds to several minutes, were observed in five out of 10 animals that received either of the two doses. No animal died during the 1 h period of observation. It would appear that levamisole is much less toxic to the guinea-pig heart than to the heart of the rat.
Onuaguluchi
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Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu.
Igbo
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IN
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D007978:Levamisole / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats
D007978:Levamisole