[The sorption of a protein-polysaccharide complex isolated from Neisseria meningitidis serogroup B on aluminum hydroxide gels and the immunological activity of the sorbed preparations].
The protein-polysaccharide complex, isolated from group B N. meningitidis, is a variant of vaccine for the prophylaxis of group B N. meningitidis infection. In this investigation the influence of the complex of the physical properties of aluminium hydroxide gels, the amount of gel, pH and the duration of sorption on the process of sorption has been studied. Aluminium hydroxide has been shown to produce a stimulating effect on the response of mice to the polysaccharide and protein contained in the complex after immunization made in two injections. Gels with a smaller particle size have been found to possess greater adjuvant activity, as well as greater absorbing activity. The immunological activity of the complex, adsorbed ex tempore, has proved to be no different from that of the complex adsorbed in an hour.
Bugaev
L V
LV
Vartanian
Iu P
IuP
Karabak
V I
VI
Kil'diushevskaia
T V
TV
Kuvakina
V I
VI
Basnak'ian
I A
IA
Alliluev
A P
AP
Machul'skaia
K V
KV
Borovkova
V M
VM
Petrov
A B
AB
D000536:Aluminum Hydroxide; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology / Q000302:isolation & purification*; D001428:Bacterial Vaccines / Q000276:immunology / Q000302:isolation & purification; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005782:Gels; D006863:Hydrogen-Ion Concentration; D007114:Immunization; D007163:Immunosorbent Techniques; D008070:Lipopolysaccharides / Q000276:immunology / Q000302:isolation & purification*; D051379:Mice; D008808:Mice, Inbred CBA; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology; D010316:Particle Size; D012703:Serotyping; D013997:Time Factors
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D005782:Gels; D008070:Lipopolysaccharides; D000536:Aluminum Hydroxide
Sorbtsiia belkovo-polisakharidnogo kompleksa, vydelennogo iz Neisseria meningitidis serogruppy B, na geli gidroksida aliuminiia i immunologicheskaia aktivnost' sorbirovannykh preparatov.