title: [Post-transfusion purpura. An unknown cause of acute immune thrombocytopenia. 4 new cases].
abstract: Post-transfusion purpura is characterized by the occurrence of acute immune thrombocytopenia 5 to 10 days after transfusion of platelet-containing blood products in subjects who had been alloimmunized to specific platelet antigens. Four cases are reported here. Three of these 4 patients, who had a rare PLA1 platelet phenotype, had developed, during a previous sensitization (pregnancy n = 2, transfusion n = 1), an allo antibody directed against PLA1 antigen. The fourth patient presented a specific anti-PLA2 antibody. Thrombocytopenia (platelet count between 4 and 40 x 10(9)/1) appeared 1 to 12 days after the responsible transfusion and showed as haematomas (n = 3) or haemoptysis (n = 1). One patient was asymptomatic and remained untreated. The remaining 3 patients received corticosteroids orally associated, in one case, with infusions of human immunoglobulin concentrates. Thrombocytopenia was corrected within 5 to 13 days. In such cases, whenever another blood transfusion is necessary, a preventive treatment with perfectly platelet-free blood products is mandatory. Platelet depletion by freezing-thawing of red cell concentrates is probably not always sufficient, since recurrence was observed with such a product in one of our patients. The exact cause of immune destruction of autologous platelet remains a mystery.
authors: Centre départemental de transfusion sanguine, Hôpital Henri Mondor, Créteil.
authors: B
authors: B
authors: Godeau
authors: P
authors: P
authors: Fromont
authors: A
authors: A
authors: Bettaieb
authors: N
authors: N
authors: Duedari
authors: P
authors: P
authors: Bierling
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000276:immunology*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011233:Precipitin Tests; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000209:etiology* / Q000276:immunology; D012008:Recurrence; D012189:Retrospective Studies; D065227:Transfusion Reaction
vernacular_title: Le purpura post-transfusionnel. Une cause méconnue de thrombopénie aiguë immunologique. Quatre nouveaux cas.