[Effects of T-activin on the course of ischemic heart disease in cases of the development of sensitization to apoprotein B-containing lipoproteins].
A comprehensive clinicoimmunological examination was made of 105 male patients aged 35-65 years who suffered from coronary heart disease. The authors identified a group of 33 patients whose unstable course of angina pectoris was associated with pronounced apolipoprotein B sensitization, as well as with the presence of the autoimmune lipoprotein-antibody complex and abnormalities in the cellular link of immunity. All 33 patients received antianginal agents. Out of them, 15 patients took additionally a course of T-activin therapy to modulate immunological shifts. The results of the examination demonstrated that the immunomodulator exerted a beneficial effect both on the course of CHD (reduction in the number of anginal episodes, improvement of left ventricular contractility) and the immune system (recovery of T-suppressor function, disappearance of lipoprotein sensitization, decrease in the patient's blood detection rates of the autoimmune lipoprotein-antibody complexes from 83 to 28%). The highest effect was reached by T-activin 1.5-2 months following termination of the course therapy. Immunomodulating therapy is regarded as an additional approach to the treatment of CHD patients with marked lipoprotein sensitization.
Klimov
A N
AN
Lopukhin
Iu M
IuM
Almazov
V A
VA
Nagornev
V A
VA
Sergeeva
E G
EG
Pigarevskiĭ
P V
PV
Ogurtsov
R P
RP
Denisenko
A D
AD
Sofronov
B N
BN
Popov
V G
VG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D003327:Coronary Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B; D001323:Autoantibodies; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Vliianie T-aktivina na techenie ishemicheskoĭ bolezni serdtsa v sluchaiakh razvitiia sensibilizatsii k apoprotein-B-soderzhashchim lipoproteidam.