[Effect of pesticides on selected biochemical parameters in the serum and liver of rats].
The experiments were carried out on male Wistar rats, weighing 200-250 g. The animals received oil or oily solutions of carbaryl, parathion-methyl and IPO62 in doses of 0.5, 0.1 or 0.02 LD50. 1, 2, 4 or 24 h after the administration of pesticides, the activities of ChE and blood glucose level, liver glycogen level, FFA and TG concentrations in serum and TG level in liver were estimated. Comparing the enzymatic changes in acute intoxications with carbaryl, parathion-methyl or IPO62, in the same doses, it was found that mechanisms of efficacy of those compounds had different trends. Changes in the activities of such parameters as ChE in serum, BGR, AspAT and AlAT in serum and liver and blood glucose level depend on the dose of pesticides and this effect is observed for IPO62, parathion-methyl and carbaryl.
Pawłowska
D
D
Zakład Toksykologii, Akademia Medyczna, Białymstoku.
Moniuszko-Jakoniuk
J
J
Lukaszewicz-Hussain
A
A
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D012721:Carbaryl / Q000494:pharmacology*; D002709:Chlorfenvinphos / Q000031:analogs & derivatives* / Q000494:pharmacology; D002802:Cholinesterases / Q000097:blood*; D005966:Glucuronidase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D008743:Methyl Parathion / Q000494:pharmacology*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000378:metabolism*
D001786:Blood Glucose; D008112:Liver Glycogen; C014369:bromfenvinphos; D008743:Methyl Parathion; D000637:Transaminases; D002802:Cholinesterases; D005966:Glucuronidase; D002709:Chlorfenvinphos; D012721:Carbaryl
Wpływ pestycydów na wybrane parametry biochemiczne w surowicy i watrobie u szczurów.