[Protective effects of nicorandil on lipid peroxidation in ischemic and reperfused myocardium of rabbits].
The experiments of recirculating blood perfusion device showed that nicorandil (Nic) 0.15 mmol/L significantly decreased the content of malondialdehyde (MDA), inhibited the release of creatine kinase (CK), counteracted the increase of coronary vascular resistance (CR), and abolished the reperfusion-induced arrhythmias in isolated rabbit hearts during ischemia and reperfusion. The results indicate that Nic has protective effects on myocardial ischemic and reperfused damage, which may relate to the prevention of lipid peroxidation.
Zhang
Y M
YM
Department of Pharmacology, Fourth Military Medical University, Xi-an, China.
Zhao
D H
DH
Sheng
B H
BH
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D020108:Nicorandil; D011817:Rabbits; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil; D008315:Malondialdehyde; D003402:Creatine Kinase