title: Isoxazolylnaphthoquinone effects on the growth of Trypanosoma cruzi.
abstract: Knowing the need for new drugs against the etiologic agent of Chagas disease and considering the biological properties of naphthoquinones and isoxazoles, the effect of three isoxazolyl-naphthoquinones on the growth of Trypanosoma cruzi was studied. To evaluate the activity of the compounds on epimastigote forms, growth curves with different concentrations of 2-hydroxi-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-4 -imine (I), N-(3,4-dimethyl-5-isoxazolyl)-4-amino-1,2-naphthoquinone (II), 2-acetyl-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone-imine (III) and Nifurtimox as reference drug were made. The studies on the trypomastigote form were performed on two month old BALB/c mice, evaluating parasitemia on day 13 post infection. The results obtained with epimastigotes showed that all drugs induced alterations in motility, morphology, viability and/or lysis of parasites. For the treatments on trypomastigotes the best results were obtained with (I) which reduced parasitemia compared to untreated controls.
authors: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
authors: P I
authors: PI
authors: Amuchástegui
authors: E R
authors: ER
authors: Moretti
authors: B
authors: B
authors: Basso
authors: N
authors: N
authors: Sperandeo
authors: M M
authors: MM
authors: de Bertorello
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D007555:Isoxazoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D009284:Naphthols / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D009547:Nifurtimox / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D007555:Isoxazoles; D009284:Naphthols; D009285:Naphthoquinones; D014344:Trypanocidal Agents; C070801:2-acetyl-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone imine; C070800:2-hydroxy-N-(3,4-dimethyl-5-isoxazolyl)-1,4-naphthoquinone imine; C066271:N-(3,4-dimethyl-5-isoxazolyl)-4-amino-1,2-naphthoquinone; D009547:Nifurtimox