Hypersensitivity reaction after orgotein (superoxide dismutase) administration.
Orgotein is being increasingly used in the treatment of some inflammatory disorders. Up to now no hypersensitivity reaction has been reported. We present the case of an allergic reaction demonstrated by both, "in vivo" and "in vitro" tests. This finding further supports the need for an adequate control during and after orgotein administration.
Corominas
M
M
Allergy Unit, Hospital de Bellvitge Princeps d'Espanya, Barcelona, Spain.
Bas
J
J
Romeu
A
A
Valls
A
A
Massip
E
E
González
L
L
Mestre
M
M
Buendía
E
E
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D015153:Blotting, Western; D002478:Cells, Cultured; D003875:Drug Eruptions / Q000209:etiology*; D005832:Genital Diseases, Male / Q000209:etiology*; D006801:Humans; D007428:Intradermal Tests; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008667:Metalloproteins / Q000009:adverse effects* / Q000627:therapeutic use; D010411:Penile Induration / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008667:Metalloproteins; D013482:Superoxide Dismutase; C005180:orgotein