Human immunodeficiency virus vpr product is a virion-associated regulatory protein.
The vpr product of the human immunodeficiency virus type 1 (HIV-1) acts in trans to accelerate virus replication and cytopathic effect in T cells. Here it is shown that the HIV-1 viral particle contains multiple copies of the vpr protein. The vpr product is the first regulatory protein of HIV-1 to be found in the virus particle. This observation raises the possibility that vpr acts to facilitate the early steps of infection before de novo viral protein synthesis occurs.
Cohen
E A
EA
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Dehni
G
G
Sodroski
J G
JG
Haseltine
W A
WA
D015704:CD4 Antigens / Q000032:analysis; D003062:Codon / Q000235:genetics; D016336:Gene Products, vpr; D005814:Genes, Viral; D005838:Genotype; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008970:Molecular Weight; D015183:Restriction Mapping; D012191:Retroviridae Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D015534:Trans-Activators / Q000378:metabolism*; D014162:Transfection; D014771:Virion / Q000235:genetics* / Q000378:metabolism; D014779:Virus Replication; D054325:vpr Gene Products, Human Immunodeficiency Virus
D015704:CD4 Antigens; D003062:Codon; D016336:Gene Products, vpr; D012191:Retroviridae Proteins; D015534:Trans-Activators; D054325:vpr Gene Products, Human Immunodeficiency Virus