Imaging of ovarian cancer with radiolabelled monoclonal antibodies.
This article presents the state of the art of immunoscintigraphy (IS) of ovarian cancer. We will review the monoclonal antibodies (MoAbs) used in clinical trials: (HMFG1/2, OC125, H317, H17E2, NDOG2 and 791T/36). We conclude that none of the afore mentioned MoAbs are clearly superior and that IS cannot yet replace laparotomy for the diagnosis of ovarian cancer but may have a role in the follow-up of ovarian cancer, in timing second-look surgery and assessing the response/TD treatment.
van Kranenburg
D L
DL
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
van Kroonenburgh
M J
MJ
Trimbos
J B
JB
Fleuren
G J
GJ
Pauwels
E K
EK
D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D015201:Meta-Analysis as Topic; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal