Relevance of immuno-contraceptive vaccines for population control. I. Hormonal immunocontraception.
Human chorionic gonadotropin--subunit beta (beta-hCG) has been so far most extensively studied antigen for immuno-contraceptive properties. Studies of vaccination of non-human primates has been so far controversially reported since some antisera obtained from baboons immunized with beta-hCG had shown cross-reactivity to other tissues. Despite these problems and concerns about the complete safety of this first generation vaccine, a decision has been made to proceed with a limited clinical trials with this vaccine. Results from these trials are encouraging and indicate that contraceptive antibody titers can be achieved with permissible adjuvants. Neutralization of LH and/or FSH by circulating antibodies may impede their action and interfere with the maturation of gametes. Gonadotropin releasing hormone can be also a suitable target for immunological attack.
Gupta
S K
SK
Gamele Antigens Unit, National Institute of Immunology, JNU Campus, New Delhi, India.
Koothan
P T
PT
D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors / Q000276:immunology; D003269:Contraception, Immunologic / Q000379:methods*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors / Q000276:immunology; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000276:immunology; D006801:Humans; D008297:Male; D011155:Population Control / Q000379:methods*; D014612:Vaccines
D006063:Chorionic Gonadotropin; D014612:Vaccines; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone