[Effect of clebopride on gastric emptying studied using a physiologic meal marked with Tc 99m colloid in subjects with non-ulcer dyspepsia].
The authors studied the action of clebopride on gastric emptying in subjects with non-ulcer dyspepsia by using radioactive isotopes. Eighteen subjects complaining of dyspeptic symptoms were studied in whom the tests undertaken had not shown organic lesions of the digestive tract. Tests with radioactive isotopes were performed before and after administration of clebopride (0.5 mg, three times daily for 15 days). In all patients gastric emptying time was normalized and gastric peristalsis became regular. In addition, in 85% of the patients, symptoms disappeared or were markedly reduced. Side effects requiring withdrawal of the drug were not observed. The above study, therefore, showed clebopride to be a useful drug for the treatment of non-ulcer dyspepsia, thus confirming data found in the literature.
Costa
R
R
Università degli Studi di Palermo, Istituto di Clinica Medica.
Cottone
C
C
Cirrincione
M
M
Chinnici
M
M
Scaffidi
A
A
D000328:Adult; D001549:Benzamides / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors
D001549:Benzamides; D013671:Technetium Tc 99m Sulfur Colloid; C014417:clebopride
Effetti della clebopride sullo svuotamento gastrico studiato con pasto fisiologico marcato con Tc99m coll. in soggetti con dispepsia non ulcerosa.