Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas.
Frozen sections from 37 schwannomas of the VIII nerve were reacted with a panel of monoclonal antibodies to macrophage, lymphocyte, HLA-Dr invariant chain and nuclear proliferation antigens. A moderate number of macrophages was demonstrated in 96% of tumours. CD8- and CD4-lymphocytes were detected in slightly smaller numbers in up to 87% and 23% of tumours respectively. B-lymphocytes were present in only 2/32 cases and NK-cells were absent from all 16 cases tested. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 13/24 tumours. These findings may represent evidence for a degree of cellular immune response. Occasional cells featuring nuclear proliferation were detected in 15/27 cases.
Rossi
M L
ML
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Jones
N R
NR
Esiri
M M
MM
Havas
L
L
Nakamura
N
N
Coakham
H B
HB
D002467:Cell Nucleus / Q000473:pathology; D006684:HLA-DR Antigens; D006801:Humans; D007111:Immunity, Cellular; D016131:Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D009464:Neuroma, Acoustic / Q000276:immunology / Q000473:pathology*
D006684:HLA-DR Antigens