Interferon-related mental deterioration and behavioral changes in patients with renal cell carcinoma.
Five out of 38 patients (13%) with metastatic renal cell carcinoma had mental deterioration 3 weeks to 13 months after the start of treatment with recombinant interferon alpha-C. Metastatic spread to the brain, paraneoplastic effect of the tumor on the central nervous system and other causes of dementia were excluded. Computed tomography of the brain in these patients was normal and the width of the cerebral sulci and ventricles did not correlate with the severity of dementia. Specific patterns of atrophy were not seen. General deterioration, assessed by the change in Karnofsky performance status, was associated with dementia. The dementia may have been caused by a neurotoxic effect of interferon.
Merimsky
O
O
Department of Oncology, Tel Aviv Sourasky Center, Ichilov Hospital, Israel.
Reider-Groswasser
I
I
Inbar
M
M
Chaitchik
S
S
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000523:psychology*; D003072:Cognition Disorders / Q000139:chemically induced; D003704:Dementia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed
D007370:Interferon Type I; D011994:Recombinant Proteins