The red cell charge in steroid--responsive nephrotic syndrome.
It has been suggested that the negative charge on the surface of red blood cells (RBC) may reflect the charge on the glomerular capillaries. Measurements were made of RBC charge in patients with steroid-responsive nephrotic syndrome (SRNS) based on the binding of a cationic dye, alcian blue. There was no difference found between patients in relapse and in normal controls. We conclude that RBC charge measurements are not a reliable indicator of the glomerular charge barrier and a more specific method is required.
Murugasu
B
B
Department of Paediatrics, National University of Singapore.
Yap
H K
HK
Tay
A H
AH
D000328:Adult; D000423:Alcian Blue; D001485:Basement Membrane / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004594:Electrophysiology; D004910:Erythrocyte Membrane / Q000502:physiology*; D006801:Humans; D009404:Nephrotic Syndrome / Q000097:blood* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D000423:Alcian Blue