Pharmacokinetics of teicoplanin in burn patients.
The pharmacokinetics of teicoplanin were studied in 21 adult burn patients and in 5 healthy controls. All subjects were given a single dose of teicoplanin, 10 mg/kg i.v. The pharmacokinetic parameters of teicoplanin were calculated using a tri-exponential model. Three parameters were investigated--burn surface area, creatinine clearance and time of administration after injury (3 days, 8-10 days and 15-20 days respectively). The elimination half-life was not significantly different between the control group (47 +/- 6 hours), the group with a burn surface area greater than 40% (64 +/- 38 hours), and the group with a burn surface area of 25-30% (44 +/- 15 hours). Trough serum concentrations at 12 hours were consistently less than 8 mg/l in all groups. There was some degree of correlation between creatinine clearance and renal clearance of teicoplanin (p = 0.03; r = 0.44). However, there was no correlation between burn surface area and creatinine clearance, or between the time of administration and creatinine clearance. Non-renal clearance of teicoplanin was unaffected by a large burn surface area. The conclusions from this study are as follows. Burn surface area and time of administration after injury are not predictive factors for the determination of an appropriate dose regimen. Trough serum concentrations at 12 hours emphasize the need for a further intravenous bolus. Burn patients with a high creatinine clearance (greater than 140 ml/min) should be carefully monitored.
Potel
G
G
Laboratoire d'Antibiothérapie Expérimentale et Clinique, Faculté de Médecine, Nantes, France.
Moutet
J
J
Bernareggi
A
A
Le Normand
Y
Y
Meigner
M
M
Baron
D
D
D000328:Adult; D000368:Aged; D002056:Burns / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D006020:Glycopeptides / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008875:Middle Aged; D017334:Teicoplanin
D006020:Glycopeptides; D017334:Teicoplanin; D003404:Creatinine