title: Solution-phase synthesis of alpha-rat atrial natriuretic peptide (alpha-rANP).
abstract: alpha-Rat atrial natriuretic peptide (alpha-rANP) was synthesized by assembling five peptide fragments in solution, followed by HF-dimethylselenide-m-cresol deprotection and subsequent air-oxidation. Synthetic alpha-rANP exhibited more potent diuretic and natriuretic activity in rats than synthetic alpha-hANP.
authors: Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
authors: M
authors: M
authors: Yoshida
authors: M
authors: M
authors: Shimokura
authors: Y
authors: Y
authors: Fujiwara
authors: T
authors: T
authors: Fujisaki
authors: K
authors: K
authors: Akaji
authors: Y
authors: Y
authors: Kiso
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis*; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats
chemical_list: D009320:Atrial Natriuretic Factor