Release of iron from ferritin by 6-hydroxydopamine under aerobic and anaerobic conditions.
6-hydroxydopamine (6-OHDA) proved to be a very effective agent for iron release from ferritin. Iron release was enhanced in the presence of SOD, catalase and under anaerobic conditions. Ascorbic acid, a well known agent able to release iron from ferritin, increased the amount of released iron in more than an additive manner when used in combination with 6-OHDA. Similar to 6-OHDA, 6-hydroxydopa (Topa) and 1,2,4-benzenetriol were also able to release iron in large amounts; in contrast, catecholamines and other benzenediols were comparatively ineffective.
Lode
H N
HN
Children's Hospital, Dept. Hematology and Oncology, University of Tuebingen, FRG.
Bruchelt
G
G
Rieth
A G
AG
Niethammer
D
D
D000332:Aerobiosis; D000693:Anaerobiosis; D001205:Ascorbic Acid / Q000494:pharmacology; D002374:Catalase / Q000494:pharmacology; D005293:Ferritins / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D016627:Oxidopamine; D013482:Superoxide Dismutase / Q000494:pharmacology
D006892:Hydroxydopamines; D016627:Oxidopamine; D005293:Ferritins; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid