[The genetic regulation of host response to inoculation with Mycobacterium bovis (BCG) and Mycobacterium tuberculosis H37RV].
Vaccination with M. bovis (BCG) essentially prolonged survival time (ST) of several strain mice, with the exception, of CBA/N, infected with M. tuberculosis H37Rv. ST of CBA/N, differing from CBA by xid mutation, was not prolonged by vaccination. Mouse strains with alternative alleles of BCG gene (s and r) and fzy gene as a genetic marker for Bcg5 were used for segregation analysis. It was shown that ST, the level of DTH reaction of mice infected with M. tuberculosis H37Rv, and protective effect of BCG vaccination did not depend on Bcg gene. However, Bcg gene, apparently, regulate the DTH response to PPD in mice only vaccinated with M. bovis (BCG).
Nikonenko
B V
BV
Mezhlumova
M B
MB
Moroz
A M
AM
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis / Q000235:genetics* / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D014376:Tuberculosis / Q000235:genetics / Q000276:immunology / Q000401:mortality; D014774:Virulence / Q000235:genetics / Q000276:immunology
D001500:BCG Vaccine
Geneticheskaia reguliatsiia otveta khoziaina na vvedenie Mycobacterium bovis (BCG) i Mycobacterium tuberculosis H37RV.