title: Cleavage of zearalenone-glycoside, a "masked" mycotoxin, during digestion in swine.
abstract: Comparative analyses of cereal samples pretreated with or without beta-glucosidase indicate the presence of zearalenone-glycoside. To examine the stability of zearalenone-glycoside during digestion, mixed feed was artificially contaminated with synthesized zearalenone-4-beta-D-glucopyranoside (395 micrograms/kg) and fed to a pig over a period of 14 days. The metabolites detected in feces and urine samples were zearalenone and alpha-zearalenol. These results demonstrate that zearalenone-4-beta-D-glucopyranoside is decomposed during digestion and the aglucone, zearalenone, is released. Since zearalenone-glycoside is not detected during routine analysis, but hydrolysed during digestion, it seems likely that such "masked mycotoxins" are involved in cases of mycotoxicoses.
authors: Institute for Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, University of Munich.
authors: M
authors: M
authors: Gareis
authors: J
authors: J
authors: Bauer
authors: J
authors: J
authors: Thiem
authors: G
authors: G
authors: Plank
authors: S
authors: S
authors: Grabley
authors: B
authors: B
authors: Gedek
mesh_terms: D000821:Animal Feed; D000818:Animals; D004063:Digestion; D005260:Female; D005506:Food Contamination; D005960:Glucosides / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism*; D006868:Hydrolysis; D009183:Mycotoxins / Q000378:metabolism*; D012118:Resorcinols / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*; D015025:Zearalenone / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D005960:Glucosides; D006027:Glycosides; D009183:Mycotoxins; D012118:Resorcinols; C050324:zearalenone-4-glucopyranoside; D015025:Zearalenone