Developmental immunohistochemistry of membrane proteins in the brain coded by a gene on human chromosome 21.
A monoclonal antibody, OK-2, against membrane proteins coded by a gene on chromosome 21 was obtained using hamster/human hybrid cells as an antigen, and used for a developmental study on the brains of Down's syndrome (DS) cases. The membrane proteins recognized by OK-2 were expressed earlier in neurons and vessels of DS brains than in normal brains, the difference being more marked in the temporal lobe than in the frontal lobe. This over-expression of the membrane proteins in DS brains, especially in the temporal lobe, may be related to the pathogenesis of or predisposition to Alzheimer type dementia in elderly DS cases.
Takashima
S
S
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Kuruta
H
H
Mito
T
T
Konomi
H
H
Obata
R
R
Onodera
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D009419:Nerve Tissue Proteins