Efficacy of ampicillin versus trimethoprim-sulfamethoxazole in a mouse model of lethal enterococcal peritonitis.
Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 10(3)-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.
Chenoweth
C E
CE
Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
Robinson
K A
KA
Schaberg
D R
DR
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D013293:Enterococcus faecalis; D005260:Female; D007273:Injections, Intramuscular; D051379:Mice; D008815:Mice, Inbred Strains; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D013290:Streptococcal Infections / Q000188:drug therapy / Q000401:mortality; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination