title: Increased levels of beta-human atrial natriuretic peptide-like immunoreactivity in chronically overloaded atrial tissue.
abstract: The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase in beta-human ANP-LI (beta-hANP-LI). Both total ANP-LI and beta-hANP-LI levels were associated with the presence of atrial fibrillation and with increased atrial pressure. Plasma beta-hANP-LI levels were also increased in mitral disease. These results suggest that human atrium with hemodynamic overloads is characterized by increased tissue levels of ANP and by a shift to the beta-hANP form.
authors: Department of Medicine, Tokyo Women's Medical College, Japan.
authors: M
authors: M
authors: Naruse
authors: M
authors: M
authors: Hiroe
authors: K
authors: K
authors: Naruse
authors: M
authors: M
authors: Nagata
authors: H
authors: H
authors: Ohno
authors: A
authors: A
authors: Hashimoto
authors: H
authors: H
authors: Koyanagi
authors: M
authors: M
authors: Sekiguchi
authors: H
authors: H
authors: Demura
authors: K
authors: K
authors: Hirosawa
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000276:immunology / Q000378:metabolism*; D001794:Blood Pressure; D002908:Chronic Disease; D006325:Heart Atria / Q000378:metabolism / Q000503:physiopathology; D006331:Heart Diseases / Q000378:metabolism* / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D015394:Molecular Structure; D009206:Myocardium / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D009320:Atrial Natriuretic Factor