title: [Action of sublingual nifedipine on left ventricular filling in hypertensive crisis].
abstract: We studied the left ventricular filling before and 15 minutes after sublingual absorption of one Nifedipine capsule in 33 untreated hypertensive patients (mean age: 68.6) without other cardiac disease and presenting an hypertensive access. This study was carried out with Doppler-echocardiography. Sample volume was set at the tips of mitral leaflets. The protocol included: early peak filling velocity (VE), atrial peak velocity (VA), mitral pressure half-time (T1/2), isovolumic relaxation time (TRIV), velocity time integral of total mitral curve (VTIT) and velocity time integral of atrial curve (VTIA). We also studied VE/VTIT ratio which has been correlated to peak filling rate/mitral stroke volume ratio in radionuclide angiography.
  
  
  RESULTS
  [table: see text] The variations of VA/VE, VTIA/VTIT, VE/VTIT and T1/2 are statistically significant but decrease of TRIV is not significant. The arterial blood pressure decreases from 184/103 to 153/83 and cardiac rate increases from 81.8 to 87.9 beats/minute.
  
  
  CONCLUSIONS
  On hypertensive emergencies sublingual nifedipine significantly improves rapid left ventricular filling without change of TRIV. Acceleration of cardiac rate is moderate.
authors: Service de cardiologie, centre hospitalier général, Saint-Dié, France.
authors: F
authors: F
authors: Viné
authors: J L
authors: JL
authors: Bourdon
authors: M F
authors: MF
authors: Bragard
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D006332:Cardiomegaly / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects*
chemical_list: D009543:Nifedipine
vernacular_title: Action de la nifédipine sublinguale sur le remplissage ventriculaire gauche dans le cadre de l'accès hypertensif.