title: Study on thermostabilizers for trivalent oral poliomyelitis vaccine.
abstract: Different formulations of Trivalent Oral Poliomyelitis Vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs.
authors: Fundação Oswaldo Cruz, Depro I, Rio de Janeiro, Brasil.
authors: M L
authors: ML
authors: Leal
authors: F J
authors: FJ
authors: Lopes
authors: M H
authors: MH
authors: Carvalho
authors: H A
authors: HA
authors: Moura
authors: S A
authors: SA
authors: Soares
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D011055:Poliovirus Vaccine, Oral / Q000737:chemistry*; D012044:Regression Analysis; D013696:Temperature
chemical_list: D011055:Poliovirus Vaccine, Oral