Extension of the Loo-Riegelman method to pharmacokinetic data at steady state.
The method of Loo and Riegelman is often used to calculate the relative amount absorbed as a function of time from plasma concentration data which follow a two-compartment open model. The method, however, is applicable only to single-dose data, whereas there is sometimes interest in the absorption-time profile at steady state after multiple doses. The method is modified here so that it can be applied to steady-state data and its use with a practical example is illustrated.
Nüesch
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EA
Biostatistics Department, Clinical Research, Sandoz Pharma Ltd., Basle, Switzerland.
D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption; D017275:Isradipine; D008954:Models, Biological; D010599:Pharmacokinetics; D011725:Pyridines / Q000494:pharmacology; D013223:Statistics as Topic
D002121:Calcium Channel Blockers; D011725:Pyridines; D017275:Isradipine