Penetration of clindamycin, cefoxitin, and metronidazole into pelvic peritoneal fluid of women undergoing diagnostic laparoscopy.
A single dose of clindamycin, cefoxitin, or metronidazole was administered to each of 30 women. The mean concentration of cefoxitin in pelvic fluid at 1 h exceeded those of the other two drugs (P less than 0.007). Cefoxitin concentrations were inferior to those of the other drugs when compared with the published MIC for 90% of Bacteroides fragilis strains.
Berger
S A
SA
Department of Microbiology, Tel-Aviv Medical Center, Israel.
Kupferminc
M
M
Lessing
J B
JB
Gorea
A
A
Gull
I
I
Peyser
M R
MR
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D002440:Cefoxitin / Q000493:pharmacokinetics*; D002981:Clindamycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008795:Metronidazole / Q000493:pharmacokinetics*; D010388:Pelvis
D008795:Metronidazole; D002981:Clindamycin; D002440:Cefoxitin