Evidence that weak promotion of carcinogen-initiated cells prevents their progression to malignancy.
Repeated promotion of 7,12-dimethylbenz[alpha]anthracene-initiated cells in mouse skin with 12-O-tetradecanoylphorbol-13-acetate (TPA) induces them to grow as premalignant skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated cells to papillomas and carcinomas could be prevented by exposing them previously to weak promoting regimens or to agents that mimic TPA activity.
Reddy
A L
AL
Department of Medicine, University of Washington, Seattle 98195.
Fialkow
P J
PJ
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D001592:Benzyl Alcohols / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010212:Papilloma / Q000139:chemically induced*; D011230:Precancerous Conditions; D012878:Skin Neoplasms / Q000139:chemically induced*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D001571:Benzoflavones; D001592:Benzyl Alcohols; D007211:Indoles; C066732:3-(N-acetylamino)-5-(N-decyl-N-methylamino)benzyl alcohol; C066733:6-(N-decylamino)-4-hydroxymethylindole; D014810:Vitamin E; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate; D003348:Cortisone