title: Stress and morphine mediated changes in pituitary-adrenal axis in guinea-pigs.
abstract: 1. Changes in plasma levels of B-END and cortisol were investigated in guinea-pigs receiving either stressful stimuli for various lengths of time or i.p. injections of morphine or saline. 2. A decrease in B-END levels occurred when animals were stressed, whereas cortisol was not affected. 3. Morphine (50 mg/kg i.p.) enhanced B-END and cortisol levels 5 min after injection, whereas a decrease in B-END was seen at 30 min. 4. Saline (i.p.) produced a decrease of B-END levels 30 min after injection and an increase in cortisol 5 and 10 min after injection. These findings suggest that in the guinea-pig the response of pituitary-adrenal axis to stress or morphine could change depending upon the time of sampling.
authors: Department of Physiology and Pharmacology, University School of Medicine, Murcia, Spain.
authors: M V
authors: MV
authors: Milanés
authors: J
authors: J
authors: del Rio-García
authors: T
authors: T
authors: Fuente
authors: J A
authors: JA
authors: Martínez
authors: M L
authors: ML
authors: Vargas
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*; D001615:beta-Endorphin / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001615:beta-Endorphin; D009020:Morphine; D006854:Hydrocortisone