Lymphocyte immunization generates immunosuppressive factors in women with recurrent abortions.
Women with recurrent spontaneous abortions of unknown etiology were treated with injection of their partner's lymphocytes. The effect of lymphocyte immunization is evaluated by various immunological tests. The results demonstrate the appearance of immunosuppressive factors, especially P4 protein, present in normal pregnancy, which inhibits cellular cytotoxicity.
Fizet
D
D
Service d'Immunologie Cellulaire, Centre de Transfusion et d'Hématologie, Bordeaux, France.
Bouzgarrou
R
R
Vezon
G
G
D000026:Abortion, Habitual / Q000276:immunology / Q000517:prevention & control*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007163:Immunosorbent Techniques; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D017710:Lymphocyte Transfusion; D008297:Male; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology; D016176:T-Lymphocyte Subsets
D011257:Pregnancy Proteins