Intramedullary neutrophil phagocytosis by histiocytes in autoimmune neutropenia of infancy.
We describe a case of autoimmune neutropenia of infancy in which active phagocytosis of mature myeloid cells by bone marrow histiocytes was observed. This finding in the routine hematological investigation has not been reported so far and might be helpful in suggesting the diagnosis of autoimmune neutropenia of infancy, and also in understanding the pathogenesis of peripheral neutropenia in this disease.
Shimizu
H
H
Department of Pediatrics, Aichi Medical University, Japan.
Sawada
K
K
Katano
N
N
Sasaki
K
K
Kawai
S
S
Fujimoto
T
T
D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D005260:Female; D006644:Histiocytes / Q000276:immunology*; D006801:Humans; D007223:Infant; D009503:Neutropenia / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology*; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000276:immunology