The role of insulin in the control of triacyglycerol (TG) in the rat skeletal muscles.
The role of insulin in the control of triacyglycerol (TG) in different types of skeletal muscle has not been fully recognized so the aim of the present study was to fill this gap. The experiments were carried out on control rats, those fed with olive oil or fed with the oil and treated with insulin and on streptozotocin diabetic animals at rest and there after exercise till exhaustion. The level of TG was measured in the white and red layers of the vastus lateralis, the soleus and the diaphragm. It was found that acute feeding with olive oil had no effect on TG level in either muscle type examined. Insulin administered to rats fed with oil increased TG level in the red vastus. Streptozotocin diabetes caused an increase in TG level in muscles with high oxidative potential. Exercise lowered the level of TG only in the red vastus of the diabetic rats. It is concluded that insulin may increase muscle TG level. Accumulation of TG in muscles of rats with acute diabetes is likely to be a result of the high plasma free fatty acid concentration. Acute insulin deficiency did not affect the muscle TG response to exercise.
Górska
M
M
Clinic of Endocrinology Medical School, Białystok.
Rutkiewicz
J
J
Górski
J
J
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D009132:Muscles / Q000378:metabolism*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism*
D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides