[Effects of the enkephalins on natural killer cytotoxicity].
Spleen mononuclear cells of BALB/C mice and YAC-1 cells were used in this experiment. Leucine enkephalin or methionine enkephalin at time 0 was added to cell cultures and the amount of the enzyme lactate dehydrogenase released from lysed target cells was determined 22 hours after incubation. There were on average 41% (5% to 60.7%) and 63% (46.8% to 78%) enhancements of natural killer activity in the presence of leucine enkephalin (1 x 10(-11)-1 x 10(-3) mg/ml) and methionine enkephalin (1 x 10(-15)-1 x 10(-3) mg/ml) respectively. The results showed that opioid peptides can modify NK cell function.
Lin
J
J
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D002478:Cells, Cultured; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine