[The met-enkephalin and beta-endorphin content of the blood in the early period after acute blood loss in rats].
The experiments have been performed on 164 rats and 110 mice. Met-enkephalin and beta-endorphin concentration was established to increase in the blood in the early period after acute blood loss in rats who survived after 24 hours of a follow up in the group of animals, who died during 24 hours follow up, the momentary beta-endorphin increase was noted at the 1st minute of the experiment; met-enkephalin contents in blood wasn't essentially changed. mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period. The correlation between arterial pressure values and beta-endorphin and met-enkephalin contents in the blood wasn't defined. The opioid peptides' ability to increase the organism stability to hypoxia was determined. Beta-endorphin and met-enkephalin significance in the pathogenesis of a posthemorrhagic period in acute blood loss is being discussed.
Zoloev
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GK
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D004744:Enkephalin, Methionine / Q000097:blood*; D006470:Hemorrhage / Q000097:blood* / Q000503:physiopathology; D051379:Mice; D008815:Mice, Inbred Strains; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*
D004744:Enkephalin, Methionine; D001615:beta-Endorphin
Soderzhanie met-énkefalina i beta-éndorfina v krovi v rannem periode posle ostroĭ krovopoteri u krys.