Effects of felodipine on atrial natriuretic peptide in hypertensive non-insulin dependent diabetes mellitus.
Eighteen patients with non-insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double-blind, randomised, cross-over study. Mean systemic blood pressure was significantly lower on felodipine, without producing a deleterious effect on diabetic control. Felodipine was associated with an increment in plasma renin concentration but plasma aldosterone and the renal outputs of sodium and dopamine were similar on both treatments. Plasma atrial natriuretic peptide levels were significantly reduced following felodipine treatment.
Jeffrey
R F
RF
Department of Medicine, Royal Infirmary, Edinburgh.
Capewell
S
S
Brown
J
J
Collier
A
A
Hajducka
C
C
Lee
M R
MR
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004311:Double-Blind Method; D015736:Felodipine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D001786:Blood Glucose; D009320:Atrial Natriuretic Factor; D012083:Renin; D015736:Felodipine