Modification of glybenclamide hypoglycaemia by verapamil in rabbits.
The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycaemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycaemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycaemic response of glybenclamide.
Saxena
K K
KK
Department of Pharmacology, L.L.R.M. Medical College, Meerut.
Lata
S
S
Saxena
R S
RS
Kumar
A
A
Srivastava
V K
VK
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D001786:Blood Glucose; D014700:Verapamil; D005905:Glyburide