Hairy cell leukemia preferentially expresses the IgG3-subclass.
Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.
Kluin-Nelemans
H C
HC
Department of Hematomorphology and Immunotyping, University Hospital, Leiden, The Netherlands.
Krouwels
M M
MM
Jansen
J H
JH
Dijkstra
K
K
van Tol
M J
MJ
den Ottolander
G J
GJ
Dreef
E J
EJ
Kluin
P M
PM
D000943:Antigens, Differentiation / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification*; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D011961:Receptors, Fc / Q000378:metabolism; D017452:Receptors, IgG
D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG