Fast atom bombardment mass spectrometry in the study of dopamine melanogenesis intermediates.
Fast atom bombardment was applied to the study of the intermediates of the reaction dopamine-tyrosinase after treatment with diazomethane. The identification of trimethoxyindoline, dopamine-o-quinone and dimethoxyindole was easily achieved by this ionization method, together with accurate mass measurements and collision experiments. The structures of these compounds are in agreement with those already hypothesized in studies on melanogenesis.
Allegri
G
G
Dipartimento di Scienze Farmaceutiche, Università di Padova, Italy.
Arban
R
R
Costa
C
C
Biasiolo
M
M
Curcuruto
O
O
Pozzan
A
A
Traldi
P
P
D004298:Dopamine / Q000378:metabolism*; D008543:Melanins / Q000096:biosynthesis*; D014442:Monophenol Monooxygenase / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment
D008543:Melanins; D014442:Monophenol Monooxygenase; D004298:Dopamine