title: Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue?
abstract: Adipose tissue is the chief reservoir of the essential fatty acids (n-3 and n-6). To study the incorporation of the dietary n-3 fatty acids eicosapentaenoic acid (EPA) (20:5) and docosahexaenoic acid (DHA) (22:6), and a unique monounsaturated fatty acid, cetoleic acid (22:1n-11), into adipose tissue, rabbits were fed two different processed fish oils: MaxEPA (high in EPA and DHA; Seven Sea Ltd, Hull, UK) and herring oil (high in cetoleic acid). EPA and DHA increased from 0% of total adipose tissue fatty acid, in the adipose tissue of control rabbits to 2.2% and 4.9%, respectively, in MaxEPA-fed rabbits. The DHA-to-EPA ratio in the adipose tissue was higher than that in the diet, indicating alternative metabolic pathways for EPA. In the adipose tissue of herring-oil-fed rabbits, cetoleic acid increased from 0% to 7.9% of total fatty acids. The deposition of EPA and DHA was 1.8% and 2.8%, respectively. Our data indicated that these unique long-chain unsaturated fatty acids from dietary fish oils were readily incorporated into the fat stores from whence they could be mobilized.
authors: Department of Medicine, Oregon Health Sciences University, Portland 97201.
authors: D S
authors: DS
authors: Lin
authors: W E
authors: WE
authors: Conner
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D004281:Docosahexaenoic Acids / Q000032:analysis; D015118:Eicosapentaenoic Acid / Q000032:analysis; D004883:Erucic Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D004883:Erucic Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D014280:Triglycerides; D004281:Docosahexaenoic Acids; C015058:cetoleic acid; D015118:Eicosapentaenoic Acid