title: Clinical significance of the cytogenetics of acute leukemias.
abstract: Numerous chromosome abnormalities are repeatedly found in the acute leukemias. These abnormalities have both diagnostic and prognostic utility. Some abnormalities, such as the t(4;11) (q21;q23) and t(9;22) (q34;q11) are found in both lymphoid and myeloid leukemias. In both disorders, these rearrangements are associated with a poor prognosis. Some abnormalities are found exclusively in myeloid malignancies, e.g., the t(8;21) (q22;q22) and rearrangements of chromosome 16q22, both of which carry a good prognosis. Other abnormalities are found only in lymphoid malignancies, like those of chromosome 14 at band q11 which involve T lymphoblasts. T-cell receptor (TRC) genes have been mapped to the 14q11 band. Recombinations involving the TCR alpha gene and the myc oncogene have been found in the t(8;14) (q24;q11). Similar involvement of immunoglobulin heavy chain genes and the myc oncogene has been well documented in molecular studies of B-cell lymphoma patients with a t(8;14) (q24;q32).
authors: Dept. of Medicine, Roswell Park Cancer Institute.
authors: J L
authors: JL
authors: Machnicki
authors: C D
authors: CD
authors: Bloomfield
mesh_terms: D000208:Acute Disease; D002869:Chromosome Aberrations; D003582:Cytogenetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis