C-MYC: evidence for multiple regulatory functions.
The nuclear c-myc proto-oncogene promotes cell proliferation and can inhibit terminal differentiation as well as induce immortalisation in its oncogenic form. There is increasing evidence that c-myc exerts these biological activities by modulating transcription and by directly affecting the initiation of DNA replication. The regulation of these disparate activities may involve the carboxyl end of the c-myc protein, which is essential for transformation and autosuppression of c-myc transcription. Conserved motifs in this region of the c-myc protein may mediate complex formation and sequence-specific nucleic acid binding.
Penn
L J
LJ
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Laufer
E M
EM
Land
H
H
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004261:DNA Replication / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D016259:Genes, myc / Q000502:physiology*; D006801:Humans; D016350:Leucine Zippers / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D010449:Peptide Mapping; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000502:physiology; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic / Q000502:physiology
D004268:DNA-Binding Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc