[Oxygen-derived free radicals. Their role in cardiology].
Oxygen-derived free radicals are highly reactive molecules characterized by the presence of an unpaired electron in one of its outer orbitals. They have been found responsible for some pathologic phenomenons which in the field of cardiology, occurs during tissue reperfusion of a previously ischemic area. Ischemia predisposes an outburst in the production of these molecules upon the reintroduction of oxygen during reperfusion. Animal experimental models have been designed to reduce the damages induced by free radicals using various pharmacologic agents. It is probable that these agents may form a part of the conventional treatment of certain cardiac pathologies in the future.
Iglesias
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I
Dpto. de Cardiología, Facultad de Medicina, Universidad de Navarra, Pamplona.
García Bolao
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I
Aparici
M
M
Alzamora
P
P
Alegría
E
E
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D005112:Extracorporeal Circulation; D005609:Free Radicals; D016027:Heart Transplantation; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity; D010101:Oxygen Consumption / Q000187:drug effects
D005609:Free Radicals; D010100:Oxygen
Radicales libres derivados de oxígeno. Su papel en Cardiología.