Suppressor T-lymphocyte dysfunction in MCNS: role of the H2 histamine receptor-bearing suppressor T lymphocytes.
To evaluate the number and function of suppressor T cells in children with minimal change nephrotic syndrome (MCNS), we performed an inhibition test of rosette formation and measured leukocyte procoagulant activity. The number of histamine H2 receptor-bearing T lymphocytes (histamine H2 R+ lymphocytes) was markedly decreased at the onset of MCNS but gradually increased and was normalized following steroid therapy. The production of leukocyte procoagulant activity by normal T lymphocytes was abolished by incubation with patient's lymphocytes. However, pretreatment of the normal T lymphocytes with cimetidine markedly decreased the suppression. The results suggest an abnormality in the histamine H2 receptors on the patient's suppressor T lymphocytes.
Inage
Z
Z
Department of Pediatrics, Nihon University, School of Medicine, Tokyo, Japan.
Wada
N
N
Kikkawa
Y
Y
Inami
M
M
Hirose
H
H
Kitagawa
T
T
D001779:Blood Coagulation Factors / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008297:Male; D009402:Nephrosis, Lipoid / Q000276:immunology*; D011970:Receptors, Histamine H2 / Q000276:immunology*; D012397:Rosette Formation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001779:Blood Coagulation Factors; D011970:Receptors, Histamine H2; C045071:leukocyte procoagulant activity