Structural and histoenzymatic aspects of metronidazol on rat gonads.
Metronidazol, an efficient drug for Trichomonas vaginalis, Lamblia intestinalis and some anaerobic germs, administered in a daily dose of 500 mg/kg body weight for 60 and 40 days in males and females, respectively, produces severe structural alterations (atrophy and cytolysis, more apparent in the testicle) and elicits, a functional impairment as well (modifications in the activity of some enzymes: alkaline and acide-phosphatase, Mg(2+)-ATPase, CyOx, SDH, LDH). These morphological and histoenzymological changes in the steroidogenic formations suggest that Metronidazol severily affects the gametogenesis and hormonogenesis in rat.
Sandu
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VD
Biological Research Centre, Cluj-Napoca, Romania.
Puica-Dat
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D000818:Animals; D005260:Female; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D010053:Ovary / Q000033:anatomy & histology* / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000033:anatomy & histology* / Q000187:drug effects / Q000201:enzymology
D008795:Metronidazole