[Effects of danazol on plasma levels of protein S C4b-binding protein].
In order to elucidate the response of protein S (PS) and C4b-binding protein (C4bp) to danazol, we investigated the serial changes in plasma levels of PS and C4bp during danazol administration in 4 patients with endometriosis. Both total and free PS levels were significantly increased at the time of 2 to 3 weeks after danazol administration as compared to the pretreatment values, while C4bp levels were not changed at all. These results imply that danazol administration to PS deficiency would produce a significant increase in the basal level of free PS, suggesting a potential adjunct to anticoagulant treatment in PS deficiency.
Shimmyozu
K
K
Third Department of Internal Medicine, School of Medicine, Kagoshima University.
Kadokura
N
N
Tara
M
M
Maruyama
I
I
Osame
M
M
D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D003169:Complement Inactivator Proteins; D003613:Danazol / Q000494:pharmacology*; D004715:Endometriosis / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D017293:Protein S; D013997:Time Factors
D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D017293:Protein S; D003613:Danazol