INV(12) (p13q11) and dicentric chromosomes in a secondary leukaemia with basophilia.
We report on a case of secondary myelodysplasia with basophilia. A karyotype showed 1) the involvement of 12p, which should be related to the basophilia and/or to previous drug exposure, and 2) the unexpected presence of three different dicentric chromosomes.
Huret
J L
JL
Département d'Hématologie et Oncologie Médicale, CNRS URA 1338, Hôpital Jean Bernard, Poitiers, France.
Brizard
A
A
Guilhot
F
F
Couet
D
D
Schoenwald
M
M
Savage
J R
JR
Tanzer
J
J
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001491:Basophils / Q000473:pathology*; D001752:Blast Crisis / Q000235:genetics; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D002896:Chromosomes, Human, Pair 6 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D008545:Melanoma / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D009378:Neoplasms, Multiple Primary; D012878:Skin Neoplasms / Q000188:drug therapy; D013308:Streptonigrin / Q000008:administration & dosage / Q000009:adverse effects; D013852:Thiotepa / Q000008:administration & dosage / Q000009:adverse effects; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects
D013308:Streptonigrin; D014747:Vinblastine; D003606:Dacarbazine; D013852:Thiotepa; D008727:Methotrexate