[Ganglioside GM3 derivatives and their immunomodulating effect].
The derivatives of ganglioside GM3-NeuLacCer. NeuLacSph and NeuAcLacSphAc-were obtained and their immunomodulating properties studied. These substances are shown to inhibit lymphocyte blast-transformation independently of their ceramide structure. On the contrary, the stimulation by the above GM3-derivatives of Con A-induced T-suppressor activity depends significantly on the structure of their ceramide moiety.
Diatlovitskaia
E V
EV
Koroleva
A B
AB
Suskova
V S
VS
Emets
V I
VI
Sutiusheva
L V
LV
Bergel'son
L D
LD
D000276:Adjuvants, Immunologic / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D005679:G(M3) Ganglioside / Q000031:analogs & derivatives / Q000276:immunology* / Q000302:isolation & purification; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000032:analysis; D008213:Lymphocyte Activation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000276:Adjuvants, Immunologic; D005679:G(M3) Ganglioside; D005732:Gangliosides
Proizvodnye gangliozida GM3 i ikh immunomoduliruiushchiĭ éffekt.