Thrombotic thrombocytopenic purpura associated with transient chromosomal aberrations: successful treatment with plasma exchange.
A 69-year-old woman with typical thrombotic thrombocytopenic purpura is reported, who was treated successfully by plasma exchange. An initial chromosomal analysis of peripheral blood lymphocytes revealed abnormal patterns of 45, XO/46, XX/47, XXX; a second analysis showed 45, XO/46, XX/47, XXX/47, XX + 21, and a third, performed in remission, showed a normal pattern. Skin fibroblasts showed a normal pattern even during the acute disease. The association of transient chromosomal aberrations and thrombotic thrombocytopenic purpura might be related to a viral infection.
Itoh
Y
Y
Department of Critical Care Medicine, Kansai Medical University, Moriguchi, Japan.
Taniguchi
T
T
Takeyama
N
N
Kuriki
H
H
Tanaka
T
T
D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000235:genetics* / Q000628:therapy; D012074:Remission Induction; D012867:Skin / Q000648:ultrastructure