18F-fluoro-2'-deoxyuridine as a tracer of nucleic acid metabolism in brain tumors.
The value of 18F-fluoro-2'-deoxyuridine (18F-FUdR) as a tracer for nucleic acid metabolism was studied using an experimental rat brain-tumor model. The 18F activity in the tumor tissue 45 minutes after intravenous injection of 18F-FUdR was about 12 times higher than that in the contralateral cortex. Double-labeled autoradiography with 18F-FUdR and 14C-thymidine revealed similar brain-tumor images. In contrast, an autoradiographic comparison of 18F-FUdR with 14C-aminoisobutyric acid, which reveals the impairment of the blood-brain barrier, showed very different images. Also, the 18F radioactivity in the tumor tissue was at a constant level for 30 to 120 minutes, whereas a notable increase in 18F activity with time was observed in nucleotides and acid-insoluble fractions. These results suggest that the distribution pattern of 18F-FUdR closely correlates with the metabolism of nucleic acid and that this drug could be a useful tracer for positron emission tomography.
Tsurumi
Y
Y
Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan.
Kameyama
M
M
Ishiwata
K
K
Katakura
R
R
Monma
M
M
Ido
T
T
Suzuki
J
J
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D005467:Floxuridine; D005462:Fluorine Radioisotopes; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005462:Fluorine Radioisotopes; D009696:Nucleic Acids; D005467:Floxuridine