[Production of cardiac prostanoids and the fatty acid composition of cardiac phospholipids in various types of myocardial hypertrophy].
Considerably increased production of cardiac prostanoids and intensified linoleic acid metabolism in the cardiac phospholipids were revealed in physiological myocardial hypertrophy in animals trained by swimming. The formation and secretion of cardiac prostanoids was found to be essentially reduced in pathological myocardial hypertrophy in rats with hereditarily determined arterial hypertension, which is attributed to inhibition of the metabolism of linoleic and linolenic acids in the cardiac phospholipids and to structural and functional disorders in the function of the heart.
Smirnov
I E
IE
Fatkhullin
I A
IA
Markov
Kh M
KhM
D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D005227:Fatty Acids; D010743:Phospholipids; D011453:Prostaglandins
Produktsiia kardial'nykh prostanoidov i zhirno-kislotnyĭ sostav fosfolipidov serdtsa pri razlichnykh tipakh formirovaniia gipertrofii miokarda.