[Role of renin-angiotensin system and vasopressin in the control of blood pressure in genetically hypertensive rats after sympathectomy].
Early chronic sympathectomy does not normalize blood pressure (BP) in genetically hypertensive rats of the Lyon strain (LH). The purpose of this study was to examine the role of the renin angiotensin system (RAS) and vasopressin in the residual hypertension exhibited by LH sympathectomized rats. Chronic sympathectomy was achieved by treating male LH and control normotensive LN rats with guanethidine sulfate between 1 and 13 weeks of age (60 mg/kg daily from day 7 after birth to day 25, 30 mg/kg daily from day 26 to day 70 and 30 mg/kg every other day from day 71 to day 90). At 14 weeks of age, catheters were inserted into the lower abdominal aorta and inferior vena cava via the left femoral artery and vein. After 2 days of recovery, BP was continuously recorded in the conscious freely moving animals during 3 consecutive 1-hour periods: before and after administration of either an angiotensin converting enzyme inhibitor (perindopril 2 mg/kg i.v.) or a selective vascular vasopressin antagonist [beta-mercapto- beta,beta-cyclopentamethylenepropionyl1, O-Me-Tyr2, Arg8-vasopressin, AVPX 10 micrograms/kg i.v.) and finally after conjoint administration of both drugs. At the end of each period, the efficacy of blockade was verified by the disappearance of pressor responses to respective agonists (angiotensin I 150 ng/kg i.v., Arg8-vasopressin 10 ng/kg i.v.). Chronic treatment with guanethidine resulted in the disappearance of pressor responses to tyramine (250 micrograms/kg i.v.) indicating complete functional denervation of the vessels. Under basal conditions, the 1-hour average value of mean BP (MBP) was higher in LH than in LN sympathectomized rats (134 +/- 3 vs 104 +/- 2 mmHg, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Lo
M
M
Département de physiologie et pharmacologie clinique, URA CNRS 606, faculté de pharmacie, Lyon.
Julien
C
C
Barrès
C
C
Vincent
M
M
Sassard
J
J
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure; D006145:Guanethidine; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D020913:Perindopril; D051381:Rats; D012084:Renin-Angiotensin System / Q000502:physiology*; D013563:Sympathectomy, Chemical; D014439:Tyramine / Q000494:pharmacology; D014667:Vasopressins / Q000502:physiology*
D000959:Antihypertensive Agents; D007211:Indoles; D014667:Vasopressins; D014439:Tyramine; D020913:Perindopril; D006145:Guanethidine
Rôle du système rénine angiotensine et de la vasopressine dans le contrôle de la pression artérielle chez le rat génétiquement hypertendu après sympathectomie.