[The level of immunoglobulins in the blood serum of guinea pigs with epicutaneous exposure to petroleum refinery products].
Blood serum IgG1, IgG2, IgA, and IgM were assayed by radial immunodiffusion after exposure of guinea pig skin to oil refinery products, mineral oil distillate D-11 (MOD) and furfurol (F), applied both separately and together. Application of MOD, F, and MOD + F subthreshold concentrations was found to be associated with a tendency to a reduction of IgG1 level; isolated applications of the agents in threshold concentrations involved statistically significant lowering of IgG1 (in exposure to MOD) and imbalanced levels of IgG1, IgG2, IgA, and IgM (in exposure to F). Combined application of both agents induced immunity shifts of other type as against isolated exposure.
Agakishiev
D D
DD
Guzova
V A
VA
Batalova
T N
TN
Afanas'ev
S S
SS
D000818:Animals; D005662:Furaldehyde / Q000633:toxicity; D006168:Guinea Pigs; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000032:analysis*; D008899:Mineral Oil / Q000633:toxicity; D010578:Petroleum / Q000633:toxicity*; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D007136:Immunoglobulins; D010578:Petroleum; D008899:Mineral Oil; D005662:Furaldehyde
Uroven' immunoglobulinov v syvorotke krovi morskikh svinok pri épikutannom vozdeĭstvii produktov nefteperegonki.