title: Asperfuran, a novel antifungal metabolite from Aspergillus oryzae.
abstract: Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 micrograms/ml.
authors: Department of Biotechnology, University of Kaiserslautern, FRG.
authors: W
authors: W
authors: Pfefferle
authors: H
authors: H
authors: Anke
authors: M
authors: M
authors: Bross
authors: B
authors: B
authors: Steffan
authors: R
authors: R
authors: Vianden
authors: W
authors: W
authors: Steglich
mesh_terms: D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D001236:Aspergillus oryzae / Q000145:classification / Q000378:metabolism*; D001572:Benzofurans / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D005658:Fungi / Q000187:drug effects*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; C065214:asperfuran; D005964:Glucosyltransferases; D002687:Chitin Synthase