[Effects of GABA and piracetam on the development of experimental cerebral infarction in rats and platelet aggregation in patients with cerebrovascular disorders].
GABA and Piracetam caused the improvement of the morphological state of cerebral infarction, due to intracarotid infusion of Arachidonic acid. The effect of GABA was more pronounced. The diminishing of antiaggregatory effect of Piracetam arose in patients with acute cerebrovascular disturbances, compared with the donor group. In contrast, the antiaggregatory activity of GABA increased in the patients group. The improvement of cerebral circulation under influence of GABA can be ascribed to its rheological changes.
Amroian
E A
EA
Vartazarian
N D
ND
Parsamian
L K
LK
Balian
L S
LS
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage; D001921:Brain / Q000473:pathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D010889:Piracetam / Q000494:pharmacology / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000627:therapeutic use*
D001095:Arachidonic Acids; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D005680:gamma-Aminobutyric Acid; D010889:Piracetam
Vliianie GAMK i piratsetama na razvitie éksperimental'nogo infarkta mozga u krys i agregatsiiu trombotsitov u bol'nykh s sosudistoĭ patologieĭ golovnogo mozga.