Flecainide intoxication.
A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as follows: bile, 160 mg/L; urine, 54 mg/L; vitreous humor, 7.4 mg/L; liver, 180 mg/kg; kidney, 74 mg/kg; and stomach contents, 120 mg.
Levine
B
B
Office of the Chief Medical Examiner, State of Maryland, Baltimore, Maryland 21201.
Chute
D
D
Caplan
Y H
YH
D000328:Adult; D002849:Chromatography, Gas; D005424:Flecainide / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D014018:Tissue Distribution
D005424:Flecainide