Potential usefulness of combined thromboxane A2 and serotonin receptor blockade for preventing the conversion from chronic to acute coronary artery disease syndromes.
Evidence suggests that unstable angina, non-Q-wave myocardial infarction and Q-wave myocardial infarcts represent a continuum, such that transient reduction in coronary blood flow associated with platelet aggregation and dynamic vasoconstriction at sites of coronary artery stenosis and endothelial injury lead to abrupt development of unstable angina. Factors potentially responsible for the conversion from chronic to acute coronary artery disease include endothelial injury at sites of stenosis. The endothelial injury may be the result of plaque fissuring or ulceration, hemodynamic factors (including systemic arterial hypertension or flow shear stress), infection, smoking, coronary arteriography or balloon angioplasty. Clinical and experimental animal studies suggest that interference with thromboxane and serotonin contributions to platelet aggregation and dynamic coronary artery constriction may prevent chronic coronary artery disease syndromes from converting to acute disease. To protect against this process may require both thromboxane and serotonin receptor antagonists or a combination of thromboxane synthesis inhibitor and receptor antagonist with a serotonin receptor antagonist. Further studies are needed to test this hypothesis.
Willerson
J T
JT
Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas.
Golino
P
P
Eidt
J
J
Yao
S K
SK
Buja
L M
LM
D000789:Angina, Unstable / Q000503:physiopathology; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D009203:Myocardial Infarction / Q000503:physiopathology; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D017482:Receptors, Thromboxane; D012701:Serotonin / Q000502:physiology; D013928:Thromboxane A2 / Q000502:physiology; D013929:Thromboxane B2 / Q000502:physiology
D011982:Receptors, Prostaglandin; D011985:Receptors, Serotonin; D017482:Receptors, Thromboxane; D012701:Serotonin; D013929:Thromboxane B2; D013928:Thromboxane A2