[Erythrocyte carbonic anhydrase in subjects on periodic hemodialysis].
Red cell carbonic anhydrase isoenzymes I and II have been measured by means of cellulose acetate membrane electrophoresis in patients with chronic renal failure and dependent on periodic hemodialysis; these patients showed a chronic anemia due to many factors. Carbonic anhydrase isoenzymes were higher in uremic and anemic patients than in the controls. Since hemoglobin can act as a protons acceptor from the active site of carbonic anhydrase during the hydratation of CO2 (and vice-versa), the increase of carbonic anhydrase can facilitate, via the Bohr effect, the transfer of the oxygen to the peripheral tissues. Therefore an increase of red cell carbonic anhydrase can constitute a compensating mechanism of anemic hypoxia in uremic patients.
Squarzoni
G
G
Istituto di Semeiotica Medica, Università di Ferrara.
Bariani
L
L
Ughi
M
M
Squerzanti
R
R
Bariani
M C
MC
Fersini
C
C
Castaldi
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002256:Carbonic Anhydrases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D007527:Isoenzymes; D002256:Carbonic Anhydrases
Anidrasi carbonica eritrocitaria in soggetti sottoposti ad emodialisi periodica.