title: A histological study of the Shionogi adenocarcinoma 115 grown in male and female mice.
abstract: We have previously demonstrated that growth rate and morphology differ between androgen-responsive Shionogi mouse mammary tumours maintained in male and female mice. Furthermore, we can modulate the growth rate of these tumours in male mice by exposing the mice to psychosocial stressors. In the present study, we were interested in determining if tumours in male mice with a comparable growth rate to that in females, also had a morphology similar to that in females. SC115 tumours were examined using histochemical and immunohistochemical techniques. Tumours in male mice were easily distinguishable from tumours in female mice regardless of growth rate. Tumours maintained in female mice contained osteoid-like regions which stained positive for sialic acid and sulphate moieties. No such regions were observed in any of the tumours from male mice. In addition, although all tumours contained MSA (muscle specific actin)-positive and S100 protein-positive cells, these regions were more extensive in the tumours of female mice. This study suggests that tumour growth rate and morphology are independently regulated by the host environment.
authors: Department of Anatomy, University of British Columbia, Vancouver, Canada.
authors: G J
authors: GJ
authors: Rowse
authors: R E
authors: RE
authors: Rowan
authors: A J
authors: AJ
authors: Worth
authors: P E
authors: PE
authors: Reid
authors: J
authors: J
authors: Weinberg
authors: J T
authors: JT
authors: Emerman
mesh_terms: D000199:Actins / Q000378:metabolism; D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D006651:Histocytochemistry; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D051379:Mice; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D009418:S100 Proteins / Q000378:metabolism; D012727:Sex Characteristics; D013315:Stress, Psychological
chemical_list: D000199:Actins; D009418:S100 Proteins