Malformation spectra and embryolethality following intraamniotic administration of glucocorticoids in the chick embryo.
The effects of a natural hormone hydrocortisone and of the synthetic corticoids dexamethasone and triamcinolone on several morphogenetic systems were investigated in 2, 3, 4 and 5 day-old chick embryos. Embryotoxic doses of the glucocorticoids were administered subgerminally on day 2, and intraamniotically on days 3, 4 and 5 of incubation. On the basis of morphological analysis of embryos performed on day 8 the malformation spectrum was determined, which shows nearly identical characteristics in all the corticoids under study. Morphogenetic systems of the body wall and face were affected most frequently; the eye only to a little extent, and the brain only rarely. No malformations of the limbs, trunk and heart were found. Embryolethal effect was observed approximately in a quarter of embryos of the individual experimental groups.
Kosar
K
K
Department of Pharmacological Propaedeutics, Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia.
D000009:Abdominal Muscles / Q000187:drug effects / Q000196:embryology; D000014:Abnormalities, Drug-Induced; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology; D002642:Chick Embryo / Q000187:drug effects*; D003907:Dexamethasone / Q000633:toxicity*; D005123:Eye / Q000187:drug effects / Q000196:embryology; D005145:Face / Q000196:embryology; D006854:Hydrocortisone / Q000633:toxicity*; D009024:Morphogenesis / Q000187:drug effects; D014222:Triamcinolone Acetonide / Q000633:toxicity*
D003907:Dexamethasone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone