The physiological and biological significances of human atrial natriuretic peptide in neonates.
The purpose of our study was to analyze the physiological and biological significances of the high human atrial natriuretic peptide (hANP) levels during early post-natal period. The absolute values or changes of plasma hANP concentrations did not correlate with the absolute values or changes of body weight, blood pressure, urinary sodium/creatinine and urinary aldosterone/creatinine ratios. Gel permeation chromatography of samples from two neonates revealed the presence of two molecular forms of hANP, alpha and beta, both in the plasma and urine. In the plasma, the beta-hANP was predominant on the 3rd day of life and the alpha-hANP on the 6th day of life. The change from one form to another was independent of the absolute value of hANP. We obtained no evidence suggestive of a physiological role of the high plasma hANP concentration during the early post-natal period. However, because of biological differences between these two fractions, their distribution must be taken into account when attempting to interpret the high hANP values observed in neonates.
Ito
Y
Y
Department of Pediatrics and Child Health, Kurume University, School of Medicine, Japan.
Marumo
F
F
Ando
K
K
Hayashi
M
M
Yamashita
F
F
D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism* / Q000502:physiology / Q000652:urine; D001794:Blood Pressure; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007231:Infant, Newborn
D009320:Atrial Natriuretic Factor