The nucleotide excision repair epistasis group in Neurospora crassa.
DNA repair mutants in eucaryotes are normally assigned to three epistasis groups. Each epistasis group represents a "pathway" for DNA repair. The pathways are commonly designated (1) nucleotide excision repair, (2) recombination repair and (3) mutagenic repair. An excision repair epistasis group has been established in Neurospora and the mutants assigned to this group should be limited in their ability to excise pyrimidine dimers and other bulky lesions from DNA. Using a pyrimidine dimer-specific assay, we have found that all Neurospora crassa mutants assigned to the excision repair epistasis group are capable of removing pyrimidine dimers from the DNA at a rate similar to the wild-type organism.
Baker
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TI
Department of Microbiology, School of Medicine, University of New Mexico, Albuquerque 87131.
Cords
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CE
Howard
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CA
Radloff
R J
RJ
D004260:DNA Repair; D004271:DNA, Fungal; D004843:Epistasis, Genetic; D009154:Mutation; D009492:Neurospora crassa / Q000235:genetics*; D011740:Pyrimidine Dimers
D004271:DNA, Fungal; D011740:Pyrimidine Dimers