title: [One-stage "forced" closure of large congenital defects of the abdominal wall with mechanical ventilation and curarization. Clinical evaluation].
abstract: Advantages of primary fascial closure of abdominal wall defects are mainly in reducing the number of staged procedures with related complications and the need of multiple operation. Nevertheless correction of large defects still remains a challenge to pediatric surgeon. Postoperative paralysis and mechanical ventilation after intraoperative milking of intestinal content and abdominal muscles stretching have been reported to reduce the risks of "forced" primary closure. A series of 64 Omphalocele and Gastroschisis has been reviewed. Associated anomalies are still the main cause of mortality among Omphalocele. Prematurity plays a secondary role on survival of Gastroschisis cases; deaths were mainly due to sepsis. Primary respiratory insufficiency affected a large number of Giant Omphalocele cases (larger than 5 cm with herniated liver) and was associated to a restricted chest structure. All these cases died in the first weeks of life. Primary closure with or without postoperative paralysis and mechanical ventilation showed to reduce in a significant way the postoperative complication rate compared to staged procedures. Mortality and hospital stay were not significantly influenced by different kinds of surgical treatment among Omphalocele. Associated anomalies are an unavoidable limiting factor to survival. Among Giant Omphalocele the use of aggressive primary fascial closure with ventilatory support showed in our hands to be a safe procedure provided that a preoperative selection of cases on the basis of chest X-ray and blood gases has been made.
authors: Istituto di Patologia Speciale Chirurgica, Università Cattolica del S. Cuore, Roma, Italia.
authors: A
authors: A
authors: Calisti
authors: C
authors: C
authors: Manzoni
authors: C
authors: C
authors: Pintus
authors: L
authors: L
authors: Nanni
authors: L
authors: L
authors: Perrelli
authors: G
authors: G
authors: De Francisci
mesh_terms: D000009:Abdominal Muscles / Q000002:abnormalities*; D000367:Age Factors; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006554:Hernia, Umbilical / Q000150:complications / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000097:blood; D011184:Postoperative Period
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
vernacular_title: Chiusura "forzata" in tempo unico dei difetti congeniti maggiori della parete addominale con ventilazione meccanica e curarizzazione. Valutazione clinica.