Deleterious effects of high magnesium diets and beneficial effects of high potassium diets in hypertensive stroke-prone rats.
The effect of varying amounts of dietary magnesium (Mg) in conjunction with potassium (K) on hypertension and stroke mortality in hypertensive stroke-prone (SHRsp) rats was studied. These results show that high K (2.1%) diets strongly protect against stroke mortality and rises of blood pressure, while high Mg (0.26%) diets appeared to increase stroke mortality and accelerate the rise of blood pressure in SHRsp rats. Similarly, medium high (1.3%) levels of K in the diet significantly reduced blood pressure and stroke mortality but not nearly as much as the 2.1% K in the high K diet.
Ganguli
M
M
Renal and Hypertension Section, University of Minnesota Hospital and School of Medicine, Minneapolis 55455.
Tobian
L
L
Sugimoto
T
T
D000818:Animals; D001794:Blood Pressure; D002561:Cerebrovascular Disorders / Q000401:mortality* / Q000517:prevention & control; D004032:Diet; D006973:Hypertension / Q000401:mortality* / Q000503:physiopathology / Q000517:prevention & control; D008274:Magnesium / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D011188:Potassium / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
D008274:Magnesium; D011188:Potassium