The effect of BCG-activated macrophages on the B-16 melanoma.
The effects of BCG-activated lund and peritoneal macrophages on the development of the primary tumor and metastases of B-16 melanoma in C57B1 mice have been studied. The BCG-activated macrophages reduced significantly the incidence of metastases in all treated animals and prolonged the mean survival time only in mice with Winn type of neutralization test. The possible mechanisms implied in this biological process are discussed.
Papilian-Todoruţiu
C
C
Department of Experimental Pathology, Oncological Institue, Cluj-Napoca, Romania.
Rişcă
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R
Mulea
R
R
Daicoviciu
D
D
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008546:Melanoma, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D012074:Remission Induction
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine