Gene mapping and cystic fibrosis.
The recent molecular cloning of the gene responsible for cystic fibrosis illustrates the importance of human gene mapping to clinical medicine. Identification of a 3bp detection (delta F508) in the majority of cystic fibrosis patients will result in more accurate DNA-based diagnostic testing in cystic fibrosis families, as well as providing clues to the basic molecular defect and its relationship with alterations of anion transport in cystic fibrosis epithelial cells.
Barker
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PE
Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama, Birmingham.
D018118:Chloride Channels; D002712:Chlorides; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D000242:Cyclic AMP / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008565:Membrane Proteins; D011494:Protein Kinases / Q000235:genetics
D018118:Chloride Channels; D002712:Chlorides; D005819:Genetic Markers; D008565:Membrane Proteins; D000242:Cyclic AMP; D011494:Protein Kinases