Norepinephrine depletion reduces the effects of social and olfactory experience.
Control juvenile rats adapted normally to a new home-cage bedding odor if they were caged with rats neonatally treated with 6-hydroxydopa, but not DSP-4. Neither social nor olfactory experience influenced preferences of NE-depleted rats. In some forebrain regions of controls caged with DSP-4 rats, monoamine concentrations were depressed and a metabolite elevated, suggesting the situation was stressful. DSP-4 treatment decreased the effect of footshock on hippocampal cholinergic activity, implying that NE depletion reduced sensitivity to stress. Thus, norepinephrine may modulate the biobehavioral effects of the postweaning olfactory and social environment.
Cornwell-Jones
C A
CA
Department of Psychology, Syracuse University, NY 13244.
Decker
M W
MW
Gianulli
T
T
Wright
E L
EL
McGaugh
J L
JL
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology; D002794:Choline / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012903:Smell / Q000502:physiology*; D012919:Social Behavior; D013312:Stress, Physiological / Q000503:physiopathology*
D001596:Benzylamines; D006892:Hydroxydopamines; D016627:Oxidopamine; D002794:Choline; C012102:DSP 4; D009638:Norepinephrine