Rearrangements of the Pim-1, c-myc, and p53 genes in Friend helper virus-induced mouse erythroleukemias.
The Friend helper leukemia virus (F-MuLV) induces in mice leukemias of the erythroid, lymphoid, and myeloblastic lineages. Erythroleukemic cell DNAs were examined for genetic alterations at loci described as common proviral integration regions in MuLV-induced myeloid or lymphoid leukemias or in Friend complex-induced erythroleukemias. No alteration of the Fim-1, Fim-2, Fim-3, pvt-1, and Spi-1 loci were detected in 17 erythroleukemias, p53 gene rearrangement was observed in 6 (30%) erythroleukemias and was always associated with a loss of the germ line allele. Interestingly, genetic alterations were also detected at two loci, c-myc and Pim-1, previously described as common provirus integration regions in T lymphoid leukemias. Rearrangements of these two genes were often associated with p53 gene alteration within the same tumor.
Dreyfus
F
F
INSERM U 152, Institut Cochin de Génétique Moléculaire, Paris, France.
Sola
B
B
Fichelson
S
S
Varlet
P
P
Charon
M
M
Tambourin
P
P
Wendling
F
F
Gisselbrecht
S
S
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D015342:DNA Probes; D005622:Friend murine leukemia virus; D015321:Gene Rearrangement; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D015513:Oncogene Proteins / Q000235:genetics*; D009857:Oncogenes; D010750:Phosphoproteins / Q000235:genetics*; D016159:Tumor Suppressor Protein p53
D015342:DNA Probes; D015513:Oncogene Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53