Molecular mechanisms for lineage commitment in T cell development.
Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.
Robey
E A
EA
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Fowlkes
B J
BJ
Pardoll
D M
DM
D000818:Animals; D015704:CD4 Antigens / Q000502:physiology; D016827:CD8 Antigens / Q000502:physiology; D002874:Chromosome Mapping; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D008213:Lymphocyte Activation / Q000502:physiology*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000378:metabolism
D015704:CD4 Antigens; D016827:CD8 Antigens; D011948:Receptors, Antigen, T-Cell