title: Effects of atrial natriuretic peptide on brain oedema: the change of water, sodium, and potassium contents in the brain.
abstract: We examined the effect of atrial natriuretic peptide (ANP) administration on cerebral oedema in rats. Intravenous ANP infusion with total dose of 120 micrograms/kg and 100 micrograms/kg suppressed the elevation of water and Na contents in left middle cerebral artery (MCA) occluded and cold injured brain tissue, indicating that ANP has a suppressive effect on cerebral oedema. Similar ANP infusion at a low dose of 1 microgram/kg/h for 6 h also resulted in observation of the anti-oedematous effect in both models, with no observable occurrence of the known systemic effects of ANP on systolic blood pressure (SBP), heart rate (HR), hematocrit, or serum electrolyte ion (Na+, K+, Cl-) concentrations. The results thus suggest that the anti-oedematous effect of ANP is attributable to water and Na content control by ANP specific to the damaged tissue, possibly through inhibition of sodium transport. Taken together with a recent study in which it was shown that ANP might inhibit sodium transport in cerebral microvessel, our results suggest that ANP suppresses the development of brain oedema by inhibiting sodium transport and the coupled water influx.
authors: Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japan.
authors: S
authors: S
authors: Naruse
authors: R
authors: R
authors: Takei
authors: Y
authors: Y
authors: Horikawa
authors: C
authors: C
authors: Tanaka
authors: T
authors: T
authors: Higuchi
authors: T
authors: T
authors: Ebisu
authors: S
authors: S
authors: Ueda
authors: S
authors: S
authors: Sugahara
authors: S
authors: S
authors: Kondo
authors: T
authors: T
authors: Kiyota
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001834:Body Water / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D002536:Cerebral Arteries; D003080:Cold Temperature; D003251:Constriction, Pathologic; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
chemical_list: D009320:Atrial Natriuretic Factor; D012964:Sodium; D011188:Potassium