[Inhibition of immune cytotoxic lymphocyte induction by antilymphocyte autoantibodies from the blood serum of patients with preleukemia and leukemia].
The influence of the presence of antilymphocyte IgG autoantibodies (ALA) from sera of haematologic patients and human retrovirus-infected ones was studied by determination of the cytotoxic lymphocyte (CTL) activity in mixed lymphocyte culture (MLC). Suppressive effects of ALA were shown at different levels. For initial 48 h of MLC in the presence of ALA the inhibition of antigen presentation by monocytes was identified and such ALA activity was adsorbed by stimulated lymphocytes. Moreover ALA induced production of soluble nondializable suppressive factors as well. The latest effects were linked to IL2-dependent lymphocyte proliferation as a result of the presence of anti-IL2R autoantibodies in the spectrum of ALA. No differences between effects of ALA from serum specimens of the used groups of patients and subjects have been detected.
Etkin
A F
AF
Gurevich
M M
MM
D000961:Antilymphocyte Serum / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007938:Leukemia / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D011289:Preleukemia / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors
D000961:Antilymphocyte Serum; D001323:Autoantibodies; D007074:Immunoglobulin G
Podavlenie induktsii immunnykh tsitotoksicheskikh limfotsitov antilimfotsitarnymi autoantitelami syvorotki krovi bol'nykh predleĭkozami i leĭkozami.