title: Ethmoid and upper nasal cavity carcinoma: treatment, results and complications.
abstract: From 1970 to 1985, 45 patients with carcinoma of the upper nasal cavity and ethmoid sinuses were radically treated. The tumor parameters, treatment strategy, radiotherapy technique and the results of treatment of these patients are retrospectively analysed in this study with particular reference to complete blindness as a major complication. In most cases tumor was removed by meticulous surgical dissection, and thereafter quality-controlled radiation therapy (external therapy: mean dose 65 Gy in about 7 weeks, or external therapy with brachytherapy boost: mean dose 82 Gy in about 10 weeks) was used for this group of patients. The results show 68% recurrence-free survival at 5 years, adjusted for intercurrent deaths. Complications of treatment were seen in seven patients (16%) who developed eye damage with some loss of visual acuity, none however leading per se to complete blindness. It may be concluded that blindness may be avoided to a major extent while treating carcinomas in the nose-ethmoid areas without compromising loco-regional control.
authors: Department of Radiation Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors: A B
authors: AB
authors: Karim
authors: J H
authors: JH
authors: Kralendonk
authors: K H
authors: KH
authors: Njo
authors: J M
authors: JM
authors: Tabak
authors: W H
authors: WH
authors: Elsenaar
authors: A T
authors: AT
authors: van Balen
mesh_terms: D001766:Blindness / Q000209:etiology; D001918:Brachytherapy / Q000009:adverse effects; D003131:Combined Modality Therapy; D005005:Ethmoid Sinus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D012189:Retrospective Studies; D014792:Visual Acuity / Q000528:radiation effects