[The IgG antibody response in patients colonized by Helicobacter pylori].
The IgG antibody response specific to Helicobacter pylori was evaluated through ELISA in a group of 92 gastric patients colonized by this bacteria. 74 had gastritis and 19 gastroduodenal ulcer. Three control groups were studied in a similar way: normal adult volunteers (n = 17), adults with E coli or S typhi bacteremia (n = 30) and normal infants (n = 30). IgG antibody response to H pylori was demonstrated in 98% of colonized patients and 0% of infants. Asymptomatic individuals and those with bacteremia had high rates of antibody response (76 and 90% respectively), although this rate and also the titers of antibody response were significantly lower than that of colonized patients (p < 0.05). ELISA reactive sera from colonized patients and asymptomatic individuals evidenced a similar antibody pattern when tested by blotting. This profile was absent in non reactive sera, including those with high antibody titers to C jejuni. The presence of specific IgG antibodies to H pylori in the majority of colonized gastric patients and asymptomatic adults suggests that this infection is very common in our population.
Figueroa
G
G
Unidad de Microbiología, Universidad de Chile, Santiago.
Acuña
R
R
Jashés
M
M
Troncoso
M
M
Toledo
M S
MS
Arellano
L
L
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000918:Antibody Specificity; D016470:Bacteremia / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004927:Escherichia coli Infections / Q000276:immunology; D005756:Gastritis / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D008875:Middle Aged; D010437:Peptic Ulcer / Q000276:immunology; D014435:Typhoid Fever / Q000276:immunology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
Respuesta de anticuerpos IgG en pacientes colonizados por Helicobacter pylori.