Primary skeletal Ewing's sarcoma in Down syndrome.
Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.
Bridge
J A
JA
Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
Neff
J R
JR
Borek
D A
DA
Hackbarth
D A
DA
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002871:Chromosome Banding; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D012512:Sarcoma, Ewing / Q000150:complications* / Q000235:genetics / Q000473:pathology