Bilateral microinjection of ethosuximide into the substantia nigra does not prevent amygdala-kindled seizures.
Male Wistar rats were subjected to daily sessions of electrical amygdala kindling until a generalized seizure was observed on five consecutive days. Bilateral microinjections (0.5 microliter) of ethosuximide (ETX) (10 pg/microliters) or saline were then administered through guide cannulas into the substantia nigra (pars reticulata). No significant difference was observed between the ETX (N = 8) and saline (N = 8) groups in duration of afterdischarge or in the latency for stage 5 generalized seizures. Our results indicate that ETX applied to the substantia nigra is not effective in suppressing amygdala-kindled seizures.
Leite
J P
JP
Disciplina de Neurologia Experimental, Escola Paulista de Medicina, São Paulo, Brasil.
Bortolotto
Z A
ZA
Cavalheiro
E A
EA
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D004569:Electroencephalography; D005013:Ethosuximide / Q000008:administration & dosage / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D005013:Ethosuximide