Hormonal modulation of invitro biosynthesis of inhibin like peptide by human prostate.
The hormonal regulation of inhibin biosynthesis by human benign hyperplastic prostate tissue was studied by determining the incorporation of 3H-leucine. 3H-inhibin, synthesized de novo, was immunoprecipitated from the culture media using specific antibodies to human prostatic inhibin. Testosterone and estradiol had no effect on inhibin biosynthesis whereas hFSH and PMSG had stimulatory effect. A decrease in inhibin biosynthesis was noticed on the addition of LHRH, TRH, hCG, hLH and human prolactin.
Vanage
G R
GR
Institute for Research in Reproduction, Jehangir Merwanji Street, Parel, Bombay, India.
Phadke
M A
MA
Bandivdekar
A H
AH
Sheth
A R
AR
D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006064:Gonadotropins, Equine / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007265:Inhibins / Q000096:biosynthesis*; D008297:Male; D011388:Prolactin / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007265:Inhibins; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D005640:Follicle Stimulating Hormone