Effective inhibition of viral reproduction by hydrophobised antiviral antibodies.
A method is proposed for the inhibition of viral reproduction in cells by means of fatty-acylated antiviral antibodies which, in contrast to the unmodified antibodies, have the ability to enter the cells. The potential of this technique is demonstrated in experiments involving inhibition of the reproduction of various strains of influenza virus and respiratory syncytial virus.
Kabanov
A V
AV
Scientific Centre for Molecular Diagnostics, Ministry of Health of the USSR, Moscow.
Ovcharenko
A V
AV
Melik-Nubarov
N S
NS
Bannikov
A I
AI
Lisok
T P
TP
Klyushnenkova
E V
EV
Cherchenko
N G
NG
Alakhov VYu
Levashov
A V
AV
Kiselev
V I
VI
D000215:Acylation; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D000914:Antibodies, Viral / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D006367:HeLa Cells; D007668:Kidney; D009975:Orthomyxoviridae / Q000276:immunology / Q000502:physiology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000502:physiology*; D012995:Solubility; D013228:Stearates; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D013228:Stearates; C032034:stearoyl chloride