Cefonicid distribution into tonsillar tissue.
The kinetic profile in tonsils of cefonicid has been studied in 30 patients who underwent tonsillectomy after administration of a single intramuscular dose of 1 g. Blood and tissue samples were withdrawn 1, 2, 3, 6, 12 and 24 h after administration of the drug. The analytical determination was performed employing a microbiological method. Peak serum levels appeared at the first hour (94.2 +/- 9.83 mg/l), while peak tissue values were determined in samples collected at the third hour (11.9 +/- 3.68 mg/kg). Serum levels at the 24th hour were 3.82 +/- 1.25 mg/l. Levels in the tonsils were 7.54 +/- 2.96 mg/kg at the sixth hour, 3.34 +/- 1.42 mg/kg at the twelfth hour and 0.40 +/- 0.31 mg/kg at the 24th hour.
Scaglione
F
F
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Falchi
M
M
Ferrara
F
F
Signorelli
S
S
Aimini
R
R
D'Orsi
S
S
Pintucci
G P
GP
Fraschini
F
F
D000293:Adolescent; D000328:Adult; D001412:Bacillus subtilis / Q000187:drug effects; D001681:Biological Assay; D015790:Cefonicid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism*
D015790:Cefonicid