Closely watched clocks: molecular analysis of circadian rhythms in Neurospora and Drosophila.
Circadian rhythms represent a type of cellular regulation common to most eukaryotes. Analysis of the genetic basis of this phenomenon is beginning to provide information about how clocks function at the molecular level. Surprisingly, the first two cloned 'clock genes', one from a fruit fly and one from a fungus, share some common characteristics both genetically and in the nature of the proteins they encode. In related work, the recent identification and molecular analysis of clock-controlled genes is revealing how biological clocks control gene expression, and may pave the way for the isolation of novel 'clock genes' in the future.
Dunlap
J C
JC
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03756.
D000818:Animals; D002940:Circadian Rhythm; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D005796:Genes; D005800:Genes, Fungal; D009154:Mutation; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D014170:Transformation, Genetic