title: In vitro antimicrobial activity of imipenem in combination with vancomycin or teicoplanin against Staphylococcus aureus and Staphylococcus epidermidis.
abstract: The interaction between imipenem and two glycopeptides against staphylococci was examined for potential synergy. Imipenem in combination with vancomycin or teicoplanin exerted a synergistic or additive effect against a majority of Staphylococcus aureus and Staphylococcus epidermidis isolates tested by the checkerboard method. Synergistic inhibitory effects were frequently accompanied by synergistic bactericidal effects. For a proportion of bacterial isolates of both species, the demonstration of synergy by the checkerboard method was confirmed by time-kill studies using antibiotic combinations at the MICs or at achievable serum antibiotic levels. Only with a single isolate of Staphylococcus epidermidis was antagonism with either antibiotic combination recorded.
authors: Department of Bacteriology, Royal Victoria Hospital, Belfast, UK.
authors: J G
authors: JG
authors: Barr
authors: E T
authors: ET
authors: Smyth
authors: G M
authors: GM
authors: Hogg
mesh_terms: D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin; D015378:Imipenem