Evidence of the selective alteration of anthracycline activity due to modulation by ICRF-187 (ADR-529).
Anthracyclines are powerful anticancer drugs whose use is limited by the development of chronic cardiotoxicity. The bisdioxopiperazine compound ICRF-187 (ADR-529) specifically abrogates this toxicity both in preclinical animal models and in humans. It does this without effecting either the acute toxicities or the anticancer activity. Therefore, with a specific antagonist, the mechanism of activity of the anthracyclines can be explored. This review discusses recent clinical trials and animal models addressing this issue and concludes by hypothesizing a mechanism of action.
Green
M D
MD
Department of Medical Oncology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
Alderton
P
P
Gross
J
J
Muggia
F M
FM
Speyer
J L
JL
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D011929:Razoxane / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D011929:Razoxane