In vivo evidence that human atrial natriuretic factor-(99-126) (hANF) stimulates parasympathetic activity in man.
In a double-blind study 8 healthy male subjects received 100 micrograms human atrial natriuretic facotr-(99-126) (hANF) and NaCl0.9% in random order on different days. Following hANF injection a significant increase in cardiac beat-to-beat variation was observed (4.65% vs 5.95%). This shows that in vivo human atrial natriuretic factor stimulates cardiac parasympathetic activity in man.
Zeuzem
S
S
Center of Internal Medicine, University Hospital, Johann Wolfgang Goethe-University, Frankfurt am Main, FRG.
Olbrich
H G
HG
Haak
T
T
Jungmann
E
E
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D011897:Random Allocation; D013268:Stimulation, Chemical
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor