Counteraction of nifedipine-induced hyperglycaemia by metformin.
Nifedipine-induced hyperglycaemia in rats was counteracted by concurrent administration of metformin (500 mg/kg p.o.). However, glibenclamide (5 mg/kg p.o.) did not change the hyperglycaemic effect of nifedipine. It is suggested that nifedipine-induced hyperglycaemia was not related to pancreatic effect and might be attributed to extra pancreatic mechanism by preventing the action of insulin in the tissues. Therefore, counteraction of nifedipine-induced hyperglycaemia by metformin, may play a role in diabetic patients treated with nifedipine.
Abu-Jayyab
A R
AR
College of Pharmacy, Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.
el-Denshary
E S
ES
el-Sawaf
H A
HA
al-Bekairi
A M
AM
D000818:Animals; D005905:Glyburide / Q000627:therapeutic use; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009543:Nifedipine / Q000037:antagonists & inhibitors*; D051381:Rats
D008687:Metformin; D009543:Nifedipine; D005905:Glyburide