Morphologic and physiologic effects of thymoxamine on corneal endothelium and ciliary processes.
Either 0.2 or 0.02% thymoxamine hydrochloride was perfused across the endothelium of isolated rabbit corneas in a specular microscope. Treated corneas did not swell, compared to controls, when perfused with 0.02% thymoxamine, but swelled at 34 microns/hr after 0.2% thymoxamine compared to 10 microns/hr of controls. Morphologically, 0.2% thymoxamine caused many intracellular vacuoles, with far fewer changes after 0.02%. Replacement of the aqueous humor with 0.02% thymoxamine caused no effect on either the corneal endothelium or ciliary process, whereas 0.2% caused small, but significant, changes in both tissues.
Green
K
K
Department of Ophthalmology, Medical College of Georgia, Augusta 30912.
Chapman
J M
JM
Cheeks
L
L
Crosby
V A
VA
Hull
D S
DS
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D002924:Ciliary Body / Q000187:drug effects* / Q000473:pathology; D003315:Cornea / Q000473:pathology; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000473:pathology; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects; D013948:Moxisylyte / Q000633:toxicity*; D010477:Perfusion; D011817:Rabbits
D013948:Moxisylyte