[Estrogen receptor content in human embryo].
Estrogen receptor (ER) content was measured in 27 human embryos, aged 3 to 7 months, with 17-fluoreceinated estrone (17-FE). ER was demonstrated in a uneven distribution pattern in most human embryonic organs. Most embryonic uteri and livers and a few lungs, stomachs and spleens were ER positive. The ER gradually increased with embryonic development in target organs such as the uterus, ovary and testes, as well as in some non-target areas such as mouth and upper digestive system. The ER decreased with embryonic development in the lower digestive system and were maintained at a low level in the lung, heart, brain and lymphoid organs. In the early embryo (3 to 4 months) the ER positive cells (A, B and C type) accounted for a greater proportion of embryonic cells than they did in the late embryonic period (5 to 7 months). The A and B type cell counts fell to the lowest point in the fifth month and increased again in the sixth month. The C and D type cells reached the lowest point in the fourth month in non-target organs but the D type cells then dramatically increased in the uterus, testes and liver. It was suggested that ER play an important role in human embryonic development and differentiation. The ER may influence proliferative ability of early embryonic organs and the late hormone-specific organ growth.
Zheng
S
S
Zhejiang Branch, Hangzhou.
D005333:Fetus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis* / Q000378:metabolism
D011960:Receptors, Estrogen