The effect of disodium cromoglycate on the skin wound healing and collagen content in the wounds of rats.
The effect of disodium cromoglycate on skin wound healing and collagen formation in the wounds was studied. Disodium cromoglycate (a mast cell stabilizer) administered to the rats in a dose of 2 mg/animal was found to retard wound healing and markedly increased wound surface in all examined days (3rd, 5th, 7th, 10th, 14th day of healing). The mast cell stabilizer injected directly into wounds decreased collagen content, especially on 10th and 14th day of the healing process.
Dabrowski
R
R
Department of Pathophysiology, School of Medicine, Lódź, Poland.
Drobnik
J
J
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000378:metabolism*
D003094:Collagen; D004205:Cromolyn Sodium