title: Universal control mechanism regulating onset of M-phase.
abstract: The onset of M-phase is regulated by a mechanism common to all eukaryotic cells. Entry into M-phase is determined by activation of the p34cdc2 protein kinase which requires p34cdc2 dephosphorylation and association with cyclin.
authors: Department of Biochemistry, University of Oxford, UK.
authors: P
authors: P
authors: Nurse
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase; D016213:Cyclins; D004789:Enzyme Activation / Q000502:physiology; D005800:Genes, Fungal / Q000502:physiology; D005809:Genes, Regulator / Q000502:physiology; D007447:Invertebrate Hormones / Q000502:physiology; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D009865:Oocytes / Q000166:cytology; D010750:Phosphoproteins / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D016213:Cyclins; D007447:Invertebrate Hormones; D010750:Phosphoproteins; D011494:Protein Kinases; D016203:CDC2 Protein Kinase