Atrial natriuretic factor mRNA and binding sites in the adrenal gland.
The factor inhibiting aldosterone secretion produced by the adrenal medulla may be atrial natriuretic factor (ANF), since the latter abolishes aldosterone release in response to a number of secretagogues, including angiotensin II and K+. In this study we have shown that cells in the adrenal medulla contain ANF mRNA and therefore have the potential to synthesize this peptide. The presence of binding sites for ANF predominantly in the adrenal zona glomerulosa suggests that, if ANF is synthesized in the medulla and transferred to the cortex, it may affect mineralocorticoid status.
Nunez
D J
DJ
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, U.K.
Davenport
A P
AP
Brown
M J
MJ
D000313:Adrenal Medulla / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D001665:Binding Sites; D002417:Cattle; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis*; D014018:Tissue Distribution; D015384:Zona Glomerulosa / Q000378:metabolism
D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor