title: Effects of atrial natriuretic peptide on ischaemic brain oedema evaluated by the proton magnetic resonance method.
abstract: The effect of atrial natriuretic peptide (ANP) on cerebral oedema in rats was examined by magnetic resonance (MR). After occlusion of the left middle cerebral artery (MCA) to induce cerebral ischaemia, rats received continuous infusion of ANP for 24 h at a total dose of 120 micrograms/kg or 150 micrograms/kg. Proton relaxation times (T1 and T2) of excised oedematous tissue were measured in vitro and the area of the oedematous region was determined in vivo by the use of magnetic resonance imaging (MRI). The administration of ANP was found to decrease the lengthening of both T1 and T2 in the oedematous tissues and shown by MRI to decrease the area of the oedematous region, compared with group receiving saline. The topographic observations in vivo suggest that ANP suppress the development of the oedematous region.
authors: Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japan.
authors: S
authors: S
authors: Naruse
authors: Y
authors: Y
authors: Aoki
authors: Y
authors: Y
authors: Horikawa
authors: C
authors: C
authors: Tanaka
authors: T
authors: T
authors: Higuchi
authors: T
authors: T
authors: Ebisu
authors: S
authors: S
authors: Ueda
authors: S
authors: S
authors: Kondo
authors: T
authors: T
authors: Kiyota
authors: H
authors: H
authors: Hayashi
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology*; D002545:Brain Ischemia / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor