The treatment of unruptured tubal pregnancy with intratubal methotrexate injection under laparoscopic control.
Nine patients with unruptured tubal pregnancies of 6-9 weeks' duration were treated with methotrexate intratubal injection under laparoscopic control. Urinary hCG levels decreased immediately after completion of the procedure, with a median time of 11 days (range 1-29) to resolution. Tubal patency on the side of the ectopic gestation was confirmed by hysterosalpingography 1-3 months after the procedure in all cases. This method requires a reduced methotrexate dosage compared with intramural or intravenous therapy. The indications are unruptured tubal pregnancy of 4 cm or less in diameter and urinary hCG levels of 8000 mIU/mL or lower.
Kojima
E
E
1st Department of Obstetrics and Gynecology, Toho University School of Medicine, Tokyo, Japan.
Abe
Y
Y
Morita
M
M
Ito
M
M
Hirakawa
S
S
Momose
K
K
D000328:Adult; D006063:Chorionic Gonadotropin / Q000652:urine; D005260:Female; D006801:Humans; D007267:Injections / Q000379:methods; D010535:Laparoscopy; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy* / Q000652:urine
D006063:Chorionic Gonadotropin; D008727:Methotrexate