Effects of immunomodulating therapy in systemic sclerosis.
We reviewed studies concerning immunomodulating therapy in systemic sclerosis. These comprise mostly uncontrolled trials and case reports. Some of these studies hint at a possible beneficial effect of antimetabolites (azathioprine, 5-fluoro-uracil and methotrexate), cyclosporine and interferon-gamma. However, to give a clearcut answer on the efficacy of these drugs in systemic sclerosis, controlled studies are urgently needed.
van den Hoogen
F H
FH
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Boerbooms
A M
AM
van de Putte
L B
LB
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000477:Alkylating Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000477:Alkylating Agents; D000963:Antimetabolites; D003524:Cyclosporins; D007371:Interferon-gamma