Cilofungin inhibition of (1-3)-beta-glucan synthase: the lipophilic side chain is essential for inhibition of enzyme activity.
Taft
C S
CS
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262.
Selitrennikoff
C P
CP
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology*; D054714:Echinocandins; D005656:Fungal Proteins; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D008565:Membrane Proteins; D015394:Molecular Structure; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology*; D010455:Peptides / Q000494:pharmacology; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D008565:Membrane Proteins; D010455:Peptides; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins; C011634:aculeacin A; C042101:cilofungin; C007572:echinocandin B; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase