title: Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
abstract: We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.
authors: E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, MO 63104.
authors: J C
authors: JC
authors: Eissenberg
authors: T C
authors: TC
authors: James
authors: D M
authors: DM
authors: Foster-Hartnett
authors: T
authors: T
authors: Hartnett
authors: V
authors: V
authors: Ngan
authors: S C
authors: SC
authors: Elgin
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004331:Drosophila melanogaster / Q000235:genetics*; D015723:Gene Library; D006570:Heterochromatin / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping; D013489:Suppression, Genetic
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D006570:Heterochromatin; D015345:Oligonucleotide Probes; D000090266:Chromobox Protein Homolog 5; D004247:DNA