The association of t (13q, 14q) with Down's syndrome and its inheritance.
Cytogenetic analysis of the first child of an older couple afflicted with Down's syndrome revealed a Robertsonian translocation between the chromosomes 13, 14 in addition to trisomy 21. His mother was found to be a carrier of this translocation with no history of abortion.
Sudha
T
T
Pediatric Unit, Vijaya Hospital, Vadapalani, Madras.
Jayam
S
S
Ramachandran
R
R
D000328:Adult; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D014178:Translocation, Genetic