title: Abnormal embryonic heart rate pattern in early pregnancy associated with Down's syndrome.
abstract: The case history of a 35-year-old woman with a pregnancy following IVF treatment is presented. Transvaginal sonography revealed an abnormal pattern of the embryonic heart rate between 28 and 50 days following follicular aspiration. At term, a male infant with the characteristics of Down's syndrome was born. The diagnosis was confirmed by chromosome analysis. The implications of this observation are discussed.
authors: Department of Obstetrics and Gynaecology/IVF, Diaconessenhuis, Voorburg, The Netherlands.
authors: R
authors: R
authors: Schats
authors: C A
authors: CA
authors: Jansen
authors: J W
authors: JW
authors: Wladimiroff
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004314:Down Syndrome / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007621:Karyotyping; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D011247:Pregnancy; D014463:Ultrasonography
chemical_list: D006063:Chorionic Gonadotropin; D008596:Menotropins; D005640:Follicle Stimulating Hormone