title: Implant site: a determinant of completeness of arterial prosthesis healing in the dog and possibly in humans.
abstract: This paper compares the healing of supported knitted Dacron prostheses implanted in the descending thoracic aorta and in the subcutaneous carotid-femoral positions in each of 10 dogs. The descending thoracic aorta prostheses were 6 cm long and the carotid-femoral prostheses averaged 76 cm in length. The healing of four porous clinical axillofemoral grafts is compared to that of the experimental carotid-femoral grafts. There was little similarity between the healing observed in the descending thoracic aortic and subcutaneous positions; the descending thoracic aorta grafts healed rapidly and completely by eight weeks, with thrombus-free flow surfaces covered with confluent endothelial cells. However, the inner wall of the carotid-femoral grafts remained largely unhealed at one year, with endothelialization largely confined to a limited pannus ingrowth across the anastomoses. This indicates that the implant site in the dog is a primary determinant of the rapidity and completeness of healing. The clinical axillofemoral grafts explanted after 20 months to six and one-half years exhibited healing characteristics that were similar to those seen in the carotid-femoral position in the dog. These findings suggest that valid comparisons of interspecies healing require data obtained from similar implant locations. They present a challenge to the previously held concepts of major interspecies differences in speed and extent of tissue ingrowth based on data obtained from noncomparable implant sites.
authors: Hope Heart Institute, Providence Medical Center, Seattle, Washington 98122.
authors: K R
authors: KR
authors: Durante
authors: H D
authors: HD
authors: Wu
authors: L R
authors: LR
authors: Sauvage
authors: Q
authors: Q
authors: Shi
authors: A R
authors: AR
authors: Wechezak
authors: D E
authors: DE
authors: Coan
authors: S
authors: S
authors: Kaplan
authors: M D
authors: MD
authors: Patel
authors: M W
authors: MW
authors: Walker
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology / Q000601:surgery; D001366:Axillary Artery / Q000473:pathology / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery; D006801:Humans; D011093:Polyethylene Terephthalates; D014656:Vascular Surgical Procedures; D014945:Wound Healing
chemical_list: D011093:Polyethylene Terephthalates