[Atrial natriuretic factor and the structural and functional condition of the "hypertensive" heart].
A radioimmunoassay was used to study the structural and functional status of the myocardium and blood natriuretic factor levels in 45 patients with hypertensive disease and 17 healthy subjects. Left atrial dysfunction was revealed to affect natriuretic factor levels in the blood of hypertensive patients with moderate left ventricular hypertrophy. As myocardial contractility became lower, natriuretic factor levels were reduced. The changes found in the levels in left ventricular hypertrophic variants may be accounted for by various values of intramyocardial stress. The findings suggest that cardiohemodynamic abnormalities may affect the secretion of natriuretic factor.
Shershner
V G
VG
Polivoda
S N
SN
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000172:deficiency / Q000378:metabolism*; D006332:Cardiomegaly / Q000209:etiology*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000473:pathology
D009320:Atrial Natriuretic Factor
Predserdnyĭ natriĭureticheskiĭ faktor i strukturno-funktsional'noe sostoianie "gipertonicheskogo" serdtsa.