Atrial natriuretic factor (ANF) inhibits thyroid hormone secretion in the mouse.
Recently, thyroid follicular cells were shown to exhibit atrial natriuretic factor (ANF)-like immunoreactivity and high affinity ANF receptors. In this study, we therefore examined the effects of synthetic rat ANF1-28 on basal and stimulated thyroid hormone secretion in the mouse, according to the McKenzie technique. Iodine deficient mice were pretreated with 125I and thyroxine. ANF (3 nmol/animal) was found to inhibit the increase in blood radioiodine levels that was induced by TSH or vasoactive intestinal polypeptide (VIP). Furthermore, ANF and norepinephrine additively inhibited the TSH-induced increase in blood radioiodine levels. It is concluded that ANF inhibits thyroid hormone secretion, which, therefore, might be locally regulated by intrathyroidal ANF.
Ahrén
B
B
Department of Surgery, Lund University, Sweden.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007455:Iodine / Q000097:blood; D007457:Iodine Radioisotopes; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D013963:Thyroid Hormones / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D014660:Vasoactive Intestinal Peptide; D009320:Atrial Natriuretic Factor; D013972:Thyrotropin; D007455:Iodine; D009638:Norepinephrine