An association between alpha 1-antitrypsin phenotype and chronic liver disease.
The phenotypes of alpha-1-antitrypsin have been analyzed by isoelectric focusing on polyacrylamide gels in 232 healthy Japanese blood donors and in 240 Japanese patients with chronic liver diseases: 69 with chronic active hepatitis, 122 with liver cirrhosis, 41 with hepatocellular carcinoma and 8 with primary biliary cirrhosis. The liver cirrhosis patients had a gene frequency of 0.07 for P1*M3, which was significantly higher (P less than 0.01) than that (0.03) in blood donors. The gene frequency of P1*M3 was significantly increased in cryptogenic liver cirrhosis (P less than 0.05), and there was a tendency toward an increased frequency of P1*M3 in post-transfusion groups, and in primary biliary cirrhosis. There were also tendencies toward increased frequencies of P1*M3 in cryptogenic and post-transfusion groups of patients with chronic active hepatitis. The present study indicates that P1*M3 is a genetic or predisposing factor for chronic liver diseases, especially for cryptogenic and/or non A-non B viral chronic liver disease and also for primary biliary cirrhosis.
Kishimoto
Y
Y
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Yamada
S
S
Hirayama
C
C
D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002908:Chronic Disease; D004198:Disease Susceptibility; D006521:Hepatitis, Chronic / Q000235:genetics; D006801:Humans; D007525:Isoelectric Focusing; D008103:Liver Cirrhosis / Q000235:genetics; D008105:Liver Cirrhosis, Biliary / Q000235:genetics; D008107:Liver Diseases / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D000515:alpha 1-Antitrypsin