Solution-phase synthesis of alpha-rat atrial natriuretic peptide (alpha-rANP).
alpha-Rat atrial natriuretic peptide (alpha-rANP) was synthesized by assembling five peptide fragments in solution, followed by HF-dimethylselenide-m-cresol deprotection and subsequent air-oxidation. Synthetic alpha-rANP exhibited more potent diuretic and natriuretic activity in rats than synthetic alpha-hANP.
Yoshida
M
M
Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
Shimokura
M
M
Fujiwara
Y
Y
Fujisaki
T
T
Akaji
K
K
Kiso
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis*; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats
D009320:Atrial Natriuretic Factor