The effects of cisapride on gastro-oesophageal reflux in children with and without neurological disorders.
Cisapride was used to treat gastro-oesophageal reflux in seven children with neurodevelopmental disorders and in 15 children who were neurologically normal. 24-hour lower-oesophageal pH monitoring was carried out before and after treatment. The neurologically normal group had a statistically significant decrease after treatment in percentage time pH less than 4, but children with neurological abnormalities did not have a comparable improvement in reflux scores.
Brueton
M J
MJ
Westminster Children's Hospital, London.
Clarke
G S
GS
Sandhu
B K
BK
D000109:Acetylcholine / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000150:complications*; D002547:Cerebral Palsy / Q000150:complications; D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D004314:Down Syndrome / Q000150:complications; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D009197:Myenteric Plexus / Q000187:drug effects; D010880:Piperidines / Q000627:therapeutic use*; D012702:Serotonin Antagonists
D010880:Piperidines; D012702:Serotonin Antagonists; D000109:Acetylcholine; D020117:Cisapride