Awareness of high blood pressure stimulates platelet release reaction.
The present study aimed at testing the hypothesis of a link between mental stress and blood platelet function. Twenty-nine 19-year-old men were recruited from the 98th percentile of mean blood pressure (116 mmHg) at a routine medical screening. They were not informed about their elevated blood pressures at the time of the screening. One year later they were randomized into two groups. Group 1 (n = 16) was exposed to mental stress by a letter informing them about their high blood pressure, while group 2 (n = 13) was sent a neutral letter. At an examination 2 weeks later, heart rate (p less than 0.05) and plasma adrenaline (p less than 0.05) responses to a cold pressor test were exaggerated in the informed group. The plasma beta-thromboglobulin (beta TG) concentration was elevated in the informed group (p less than 0.05) as was mean blood pressure (p less than 0.05). beta TG correlated positively with hematocrit (r = 0.59, p less than 0.005) and mean blood pressure (r = 0.43, p less than 0.05), and negatively with plasma HDL (r = -0.61, p = 0.001). The study shows that awareness of hypertension induces a hyperadrenergic state which is associated with the platelet release reaction. Under these circumstances platelet release seems to be correlated to established coronary heart disease risk factors.
Rostrup
M
M
Department of Internal Medicine, Ullevål Hospital, University of Oslo Medical School, Norway.
Mundal
H H
HH
Kjeldsen
S E
SE
Gjesdal
K
K
Eide
I
I
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000523:psychology; D008055:Lipids / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011897:Random Allocation; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood*; D001620:beta-Thromboglobulin / Q000378:metabolism
D008055:Lipids; D001620:beta-Thromboglobulin; D009638:Norepinephrine; D004837:Epinephrine