title: Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and Down syndrome cases.
abstract: Immunohistochemical staining with polyclonal antibodies to synthetic amyloid (residues 1-28 of A4) was performed on normal and Down syndrome brains from fetuses to adults. Positive staining appeared in the cytoplasmic processes of astrocytes in the subpial layer and white matter of developing brains, and reappeared in astrocytic fibers of the subpial layer as well as in cerebrovascular and plaque core amyloid in elderly brains. The reappearance of positively stained astrocytes and amyloid occurred earlier in adult Down syndrome patients. The results indicate that the A4 protein is a developmental protein, and its reappearance in Alzheimer and adult Down syndrome brains may be related to the regeneration process.
authors: Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
authors: S
authors: S
authors: Takashima
authors: H
authors: H
authors: Kuruta
authors: T
authors: T
authors: Mito
authors: M
authors: M
authors: Nishizawa
authors: T
authors: T
authors: Kunishita
authors: T
authors: T
authors: Tabira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis*; D001253:Astrocytes / Q000737:chemistry; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000473:pathology*; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides