[The effect of hormones on tumor growth].
It is well documented that estrogen influences the growth of mammary carcinoma. Estrogen-induced response of target tissue includes protein-biosynthesis as well as stimulation of cell proliferation. Estrogen stimulates tumor cell proliferation in vitro in a dose-related manner by shortening the cell cycle time primarily at the G1 duration and by increasing the number of dividing cells per cycle. The mechanisms of estrogen action on target cell proliferation are not understood well and because of controversial experimental results the role of functional estrogen receptors in estrogen-induced proliferation is not yet clear. In this work, we studied the effect of estrogen on the growth of cells derived from primary tumors (N = 4) and malignant pleural effusions (N = 6) from patients with histopathologically verified breast cancer. We correlated steroid receptor content of malignant tissue used with results obtained for estrogen-induced cell proliferation. It was shown that there was a positive correlation between steroid receptor content and effect of estrogen on cell proliferation in most of the cases studied (7/10). Our study also confirms the possibility of positive and negative influences of estrogen on modulation of tumor cell growth.
Spuzić
I
I
Nikolić
D
D
Sami
I
I
Branković
M
M
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D004054:Diethylstilbestrol / Q000494:pharmacology*; D006801:Humans; D016066:Pleural Effusion, Malignant / Q000473:pathology; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004054:Diethylstilbestrol
Ispitivanje uticaja hormona na rast tumora.