[Focal nodular hyperplasia of the liver observed in a patient undergoing prolonged therapy with ketoconazole].
The authors report on a 44 year old man presenting focal nodular hyperplasia of the liver associated with prolonged ketoconazole therapy in the absence of known intake of either estrogens of androgens as well as of any factor that could cause hyperproduction of estrogens. It seems possible the existence of an etiopathogenic relationship between prolonged ketoconazole therapy and focal nodular hyperplasia of the liver since ketoconazole inhibits steroidogenesis and can also increase the estradiol-testosterone ratio (E/T). This hormonal alteration is known to play an important role in the pathogenesis of several hepatic neoplasms, including focal nodular hyperplasia.
Machado
M C
MC
Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo.
Jukemura
J
J
Bacchella
T
T
Leite
K R
KR
Machado
M A
MA
el Hayek
O R
OR
Pinotti
H W
HW
D000328:Adult; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced*; D007654:Ketoconazole / Q000009:adverse effects*; D008099:Liver / Q000473:pathology*; D008297:Male
D007654:Ketoconazole
Hiperplasia nodular focal do fígado observada num paciente submetido à terapêutica prolongada com ketoconazol.