The role of bone fracture at the site of carcinogen exposure on nickel carcinogenesis in the soft tissue.
The influence upon nickel subsulfide (alpha-Ni3S2; Ni-SS)-induced carcinogenesis in the soft tissue of bone fracture at the site of Ni-SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.
Ohmori
T
T
Second Department of Pathology, Ehime University School of Medicine.
Uraga
N
N
Komi
K
K
Tabei
R
R
Shibata
T
T
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005350:Fibroma / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D050723:Fractures, Bone / Q000503:physiopathology*; D007275:Injections, Intravenous; D009362:Neoplasm Metastasis; D009532:Nickel / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D013997:Time Factors
D002273:Carcinogens; D009532:Nickel; C017557:nickel subsulfide