title: Lack of effect of dietary potassium on renal lithium clearance in man.
abstract: The effects of alterations in dietary potassium (40, 80 and 160 mmol day-1) on endocrine status and on renal lithium clearance were assessed in 10 healthy subjects on a fixed sodium intake; measurements were made on the fifth day of each dietary regimen. Plasma aldosterone concentration was found to increase with potassium intake, whereas plasma renin activity and the plasma concentration of atrial natriuretic peptide did not change significantly. Neither absolute lithium clearance nor fractional lithium excretion was affected measurably by changes in dietary potassium, suggesting that provided the potassium intake remains within the normal range it is unnecessary to control this factor during lithium clearance studies in man.
authors: Department of Medicine, St George's Hospital Medical School, London, UK.
authors: Hla-Yee-Yee
authors: D G
authors: DG
authors: Shirley
authors: D R
authors: DR
authors: Singer
authors: N D
authors: ND
authors: Markandu
authors: M G
authors: MG
authors: Buckley
authors: A L
authors: AL
authors: Sugden
authors: M A
authors: MA
authors: Miller
authors: G A
authors: GA
authors: MacGregor
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D008094:Lithium / Q000652:urine*; D008297:Male; D008657:Metabolic Clearance Rate; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology*; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D008094:Lithium; D012083:Renin; D011188:Potassium