A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids.
Intraindividual comparisons of diets supplemented with sunflowerseed oil (rich in linoleic acid, LA, C18:2n-6), linseed oil (enriched with alpha-linolenic acid, LNA, C18:3n-3) and canned mackerel (rich in eicosapentaenoic acid, EPA, C20:5n-3 and docosahexaenoic acid, DHA, C22:6n-3) were made in 30 patients with primary hyperlipoproteinemia (HLP) of phenotypes IIa (n = 9), IIb (n = 7), IV (n = 7) and V (n = 7). The lipid- and blood pressure-lowering effects of polyunsaturated fatty acids (PUFA), particularly those of the EPA- and DHA-rich diet, were confirmed irrespective of the type of HLP. Apolipoproteins A-I and B remained unchanged. The most remarkable finding was a substantial depression of free fatty acids (FFA) within a standardized glucose tolerance test (GTT) associated with the fall of serum triglycerides after diets enriched with n-6 and especially after those supplemented with n-3 PUFA. It was suggested that the decrease of FFA indicates reduced peripheral lipolysis, which might be a hitherto ignored factor involved in the triglyceride-lowering action of n-6 and, more pronounced, of n-3 PUFA.
Singer
P
P
Central Institute for Cardiovascular Research, Academy of Sciences Berlin-Buch, G.D.R.
Wirth
M
M
Berger
I
I
D000328:Adult; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000178:diet therapy; D006953:Hyperlipoproteinemia Type IV / Q000178:diet therapy; D006954:Hyperlipoproteinemia Type V / Q000178:diet therapy; D006951:Hyperlipoproteinemias / Q000097:blood / Q000178:diet therapy*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage; D008042:Linolenic Acids / Q000008:administration & dosage; D008043:Linseed Oil / Q000008:administration & dosage; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood*
D004042:Dietary Fats, Unsaturated; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D008055:Lipids; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D008043:Linseed Oil; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid