[Hemodynamic and respiratory effects of enoximone in acute respiratory insufficiency of chronic obstructive bronchopneumopathy].
Hemodynamic effects and gas exchange were studied in twenty COPD patients undergoing mechanical ventilation before and 30 and 60 minutes after an intravenous administration of 1 mg/kg enoximone. Enoximone decreased significantly pulmonary arterial pressure and pulmonary vascular resistances without significantly decrease of systemic vascular resistances 60 minutes after a slight dose of 1 mg/kg. Right ventricular ejection fraction increased; O2 arterial pressure, CO2 arterial pressure, intrapulmonary shunt remained unchanged. We concluded that enoximone induced pulmonary vasodilation in patients with decompensated COPD and increased right ventricular function without deleterious effects in gas exchange.
Lefebvre
M C
MC
Urgence Respiratoire et de Réanimation Médicale, Hôpital A. Calmette, Lille.
Durocher
A
A
Saulnier
F
F
Wattel
F
F
D000208:Acute Disease; D002316:Cardiotonic Agents / Q000494:pharmacology*; D017335:Enoximone; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008173:Lung Diseases, Obstructive / Q000150:complications*; D012119:Respiration / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000503:physiopathology
D002316:Cardiotonic Agents; D007093:Imidazoles; D017335:Enoximone
Retentissement hémodynamique et respiratoire de l'enoximone au cours de l'insuffisance respiratoire aiguë des bronchopneumopathies chroniques obstructives.