[Multi-phenotype leukemia in children. Apropos of 18 cases].
Eighteen cases of pediatric acute multi-phenotypic leukemia from 24 French centers investigated during 5 years are reported. The multi-phenotypic character of these cases was shown by the paradoxical presence of 2 or 3 associated membrane antigens which are normally lineage restricted. The following bi-phenotypic combinations were found: B/T lymphoid (n = 6), B/myeloid (n = 7) or T/myeloid (n = 2). Three cases of tri-phenotypic association were also observed [B/T/myeloid (n = 2), B/myeloid/megakaryoblastic (n = 1)]. Our findings suggest that combinations with a myeloid composant and the presence of cALLA (common acute lymphoid leukemia antigen) on less than 45% of cells seem to be related to a shorter survival.
Monpoux
F
F
Laboratoire d'Immunologie, Faculté de Médecine, Vandoeuvre-lès-Nancy.
Sudaka
I
I
Philip
P J
PJ
D000208:Acute Disease; D000293:Adolescent; D000943:Antigens, Differentiation / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology; D007951:Leukemia, Myeloid / Q000150:complications / Q000276:immunology; D008297:Male; D015260:Neprilysin; D010641:Phenotype; D013920:Thrombocythemia, Essential / Q000150:complications / Q000276:immunology
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin
Leucémies multiphénotypiques chez l'enfant. A propos de 18 observations.