Haemodynamic effects of synthetic derivatives of diltiazem on isolated guinea-pig heart.
The substitution of the diltiazem acetyl-group with other chemical structures greatly influences its pharmacological properties as exerted upon the perfused heart. In particular, the substitution with a nicotinic group enhances its capacity of lowering Coronary Perfusion Pressure without the usual secondary effects observable on Heart Rate and Developed Pressure.
Carazzone
M
M
Centro di Ricerche Schiapparelli Farmaceutici, Torino.
Baudo
A
A
Borgoglio
R
R
Monni
M
M
Muccioli
G
G
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D016277:Ventricular Function, Left / Q000187:drug effects
D004110:Diltiazem