title: [Effects of T-activin on the course of ischemic heart disease in cases of the development of sensitization to apoprotein B-containing lipoproteins].
abstract: A comprehensive clinicoimmunological examination was made of 105 male patients aged 35-65 years who suffered from coronary heart disease. The authors identified a group of 33 patients whose unstable course of angina pectoris was associated with pronounced apolipoprotein B sensitization, as well as with the presence of the autoimmune lipoprotein-antibody complex and abnormalities in the cellular link of immunity. All 33 patients received antianginal agents. Out of them, 15 patients took additionally a course of T-activin therapy to modulate immunological shifts. The results of the examination demonstrated that the immunomodulator exerted a beneficial effect both on the course of CHD (reduction in the number of anginal episodes, improvement of left ventricular contractility) and the immune system (recovery of T-suppressor function, disappearance of lipoprotein sensitization, decrease in the patient's blood detection rates of the autoimmune lipoprotein-antibody complexes from 83 to 28%). The highest effect was reached by T-activin 1.5-2 months following termination of the course therapy. Immunomodulating therapy is regarded as an additional approach to the treatment of CHD patients with marked lipoprotein sensitization.
authors: A N
authors: AN
authors: Klimov
authors: Iu M
authors: IuM
authors: Lopukhin
authors: V A
authors: VA
authors: Almazov
authors: V A
authors: VA
authors: Nagornev
authors: E G
authors: EG
authors: Sergeeva
authors: P V
authors: PV
authors: Pigarevskiĭ
authors: R P
authors: RP
authors: Ogurtsov
authors: A D
authors: AD
authors: Denisenko
authors: B N
authors: BN
authors: Sofronov
authors: V G
authors: VG
authors: Popov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D003327:Coronary Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D001055:Apolipoproteins B; D001323:Autoantibodies; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
vernacular_title: Vliianie T-aktivina na techenie ishemicheskoĭ bolezni serdtsa v sluchaiakh razvitiia sensibilizatsii k apoprotein-B-soderzhashchim lipoproteidam.