title: Exercise tolerance after anaemia correction with recombinant human erythropoietin in end-stage renal disease.
abstract: The aim of this study was to evaluate the effect of correction of chronic anaemia on the physical performance and the cardiovascular response to effort in children with end-stage renal disease (ESRD) maintained by haemodialysis. Seven patients (mean age 13.9 years) underwent triangular-type treadmill exercise testing before [haemoglobin (Hb) 6.3 +/- 0.9 g/dl] and after (Hb 11.2 +/- 1.2 g/dl) anaemia correction with recombinant human erythropoietin (rHuEPO). After treatment, the work-load reached, the peak oxygen uptake and average ventilatory anaerobic threshold (VAT) values were significantly increased (P less than 0.01, P less than 0.001, P less than 0.05 respectively). VAT values, expressed as a percentage of normal values, increased from 55.7 +/- 16.6% to 82.4 +/- 21%. This improvement correlated well with the increase in Hb (r = 0.79). Oxygen pulse also increased significantly, when tested after anaemia correction. In conclusion, these data demonstrate that when the anaemia of children with ESRD is corrected with rHuEPO, there is a clear improvement in aerobic work capacity and effort tolerance.
authors: Department of Paediatrics, University of Padua, Italy.
authors: E
authors: E
authors: Baraldi
authors: G
authors: G
authors: Montini
authors: S
authors: S
authors: Zanconato
authors: G
authors: G
authors: Zacchello
authors: F
authors: F
authors: Zacchello
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism; D002648:Child; D004921:Erythropoietin / Q000627:therapeutic use*; D015444:Exercise; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D002245:Carbon Dioxide