Removal of chelated aluminium during haemodialysis using polysulphone high-flux dialysers.
Polysulphone high-flux dialysers were used for removal of chelated aluminium in desferrioxamine-treated patients on maintenance haemodialysis. When compared with charcoal haemoperfusion in series with a cuprophane dialyser, the same aluminium clearance was obtained (34% of blood flow). During 4 h of haemodialysis serum aluminium was reduced to the concentration seen before desferrioxamine infusion. We conclude that high-flux polysulphone dialysers remove chelated aluminium as efficiently as does charcoal haemoperfusion, and at a lower cost.
Aarseth
H P
HP
Department of Medicine, Ullevål Hospital, Oslo, Norway.
Ganss
R
R
D000535:Aluminum / Q000032:analysis* / Q000097:blood; D002606:Charcoal / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D015314:Dialysis Solutions / Q000032:analysis*; D006464:Hemoperfusion; D006801:Humans; D008657:Metabolic Clearance Rate; D011108:Polymers / Q000494:pharmacology*; D006435:Renal Dialysis; D013450:Sulfones / Q000494:pharmacology*
D015314:Dialysis Solutions; D011108:Polymers; D013450:Sulfones; D002606:Charcoal; C017662:polysulfone P 1700; D000535:Aluminum; D003676:Deferoxamine