title: Uneventful self poisoning with a very high dose of captopril.
abstract: A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall.
authors: Department of Internal Medicine, University of Innsbruck, Austria.
authors: P
authors: P
authors: Lechleitner
authors: A
authors: A
authors: Dzien
authors: C
authors: C
authors: Haring
authors: H
authors: H
authors: Glossmann
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning; D006207:Half-Life; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders; D013406:Suicide, Attempted
chemical_list: D009320:Atrial Natriuretic Factor; D002216:Captopril