Neurotensin-induced miosis: the role of dopaminergic pathways.
In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.
Tassorelli
C
C
Department of Neurology, C. Mondino Foundation, University of Pavia, Italy.
Spampinato
D
D
Caruso
P
P
Cavaliere
S
S
Micieli
G
G
Drago
F
F
Nappi
G
G
D000818:Animals; D003891:Desipramine; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol; D006892:Hydroxydopamines; D008297:Male; D015877:Miosis / Q000139:chemically induced* / Q000503:physiopathology; D009496:Neurotensin / Q000494:pharmacology*; D016627:Oxidopamine; D011817:Rabbits; D013563:Sympathectomy, Chemical / Q000379:methods
D006892:Hydroxydopamines; D009496:Neurotensin; D016627:Oxidopamine; D006220:Haloperidol; D003891:Desipramine; D004298:Dopamine