Meta-analysis of randomized controlled trials of antibiotic prophylaxis in abdominal hysterectomy.
The value of antibiotic prophylaxis in abdominal hysterectomy was reviewed by meta-analysis. Two independent literature searches (1986-1988) yielded 150 relevant papers, however, only 17 (11.3%) papers met our inclusion criteria. The selected papers described prospective, randomized, blinded, placebo-controlled studies of patients undergoing elective abdominal hysterectomy. In 14 of 17 (82%) trials, first- or second-generation cephalosporins were used. Results pooled confirm that antibiotic prophylaxis will reduce infectious morbidity following elective abdominal hysterectomy. Hospital stay is little affected and significant levels of infectious morbidity remain.
Wttewaall-Evelaar
E W
EW
Department of Gynaecology and Obstetrics, Diakonessen Hospital, Utrecht, The Netherlands.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D015201:Meta-Analysis as Topic; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication
D000900:Anti-Bacterial Agents