Concentration in, and binding of several metals by myelin from mice.
There was no significant difference between 6 and 28 week old mice, in the concentration of some elements, Zn, Cu, Fe and Mg in whole brain and myelin. Ca was found at a high level in myelin, compared to the whole brain. The binding activity of two neurotoxic metals, Cd and Mn to the myelin was not changed by ageing. However, the binding of some metals was different. In particular, Zn and Pb showed high values. Lipid peroxide (LPO) used as an index of age-associated changes did not increase in the brain of the 28-week-old group. However, testicular and cardiac LPO increased significantly in the 28-week-old mice than in the 6-week-old mice. At least, judging from the LPO concentration, it seems that the age-associated changes of the brain were not yet found in the 28-week-old mice.
Sugawara
N
N
Department of Public Health, Sapporo Medical College, Japan.
Chen
B Q
BQ
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008670:Metals / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D009186:Myelin Sheath / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity / Q000502:physiology; D013737:Testis / Q000378:metabolism
D008054:Lipid Peroxides; D008670:Metals; D000251:Adenosine Triphosphatases