title: Debrisoquine hydroxylation and sulfamethazine acetylation in a Chinese population.
abstract: Both debrisoquine hydroxylation and sulfamethazine acetylation phenotypes were studied in the same native Chinese population. Debrisoquine hydroxylation status was determined by HPLC assay of debrisoquine metabolic ratio in urine after a single oral dose of 10 mg debrisoquine. Three poor metabolizers were found in 220 subjects (1.36%). One hundred and one subjects of this population previously debrisoquine phenotyped were also tested for acetylation phenotyping on a separate occasion. Their acetylation status were determined by HPLC assay of "% acetylation" after a single oral dose of 1 g sulfamethazine. Twenty (19.8%) slow acetylators were found. There were no significant association between the 2 metabolic pathways.
authors: Institute of Clinical Pharmacology, Shanghai Medical University, China.
authors: X M
authors: XM
authors: Xu
authors: W D
authors: WD
authors: Jiang
mesh_terms: D000107:Acetylation; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D002851:Chromatography, High Pressure Liquid; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism*
chemical_list: D013418:Sulfamethazine; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin