The long-term effects of 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT) on copulatory and exploratory behaviour in male rats.
The long-term effects of low doses of the 5-HT1A-agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied to assess differences in the development of subsensitivity in 8-OH-DPAT-induced behavioural responses. Male rats received 33 or 100 micrograms/kg per day s.c. for 8 or 15 days. The chronic treatment did not alter the facilitatory effects of 8-OH-DPAT on male copulatory behaviour. In contrast, the effects on exploratory activity and the induction of flat body posture observed after the acute treatment were attenuated by prolonged administration of 8-OH-DPAT. The results presented indicate that gonadal hormones are involved in 5-HT receptor regulatory mechanisms.
Johansson
C E
CE
Department of Medical Pharmacology, University of Uppsala, Sweden.
Meyerson
B J
BJ
Höglund
A U
AU
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D003307:Copulation / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin