Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the voluntary consumption of ethanol, water and solid food by UChA and UChB rats.
The effects of zimelidine, fluvoxamine, and citalopram (serotonin uptake blockers), as well as those of 5-hydroxytryptophan (serotonin precursor), on the voluntary consumption of 10% ethanol solution, distilled water and solid food were tested in UChA (genetically low ethanol consumer) and UChB (genetically high ethanol consumer) rats. Since it is well known that drugs which stimulate central serotonergic synapses decrease food and water intake, the data concerning the difference of the respective consumption during the treatment period and the pretreatment one were analysed with a method previously proposed (Alcohol 5:15-19; 1988) to recognize specific effects on ethanol intake. The results showed that while the decrease of ethanol consumption induced by the three serotonin uptake blockers appeared not to be specific of ethanol, the effects of 5-hydroxytryptophan in UChB rats satisfy the criteria for being considered as an expression of a decrease of the specific appetite--or increase satiety--for ethanol. Experimental results cannot help in the explanation of this difference.
Alvarado
R
R
Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
Contreras
S
S
Segovia-Riquelme
N
N
Mardones
J
J
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D015283:Citalopram / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005260:Female; D016666:Fluvoxamine; D008297:Male; D010091:Oximes / Q000494:pharmacology; D051381:Rats; D011922:Rats, Mutant Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D015031:Zimeldine / Q000494:pharmacology
D010091:Oximes; D012702:Serotonin Antagonists; D015283:Citalopram; D015031:Zimeldine; D006916:5-Hydroxytryptophan; D016666:Fluvoxamine