Does 24-h urinary MHPG predict treatment response to antidepressants? II. Association between imipramine response and low MHPG.
Thirty depressed patients collected 24-h urine samples for a 3-methoxy-4-hydroxyphenylglycol (MHPG) determination prior to imipramine treatment. Patients responding to treatment had lower levels of MHPG than did non-responders.
Garvey
M
M
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
DeRubeis
R J
RJ
Hollon
S D
SD
Evans
M D
MD
Tuason
V B
VB
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D011569:Psychiatric Status Rating Scales
D008734:Methoxyhydroxyphenylglycol; D007099:Imipramine