The effect of carbimazole therapy on interleukin 2, interleukin 2 receptors and free radicals.
Levels of Interleukin 2 (IL2), IL2 receptors (IL2R) and free radical scavengers were measured in 25 Graves' disease patients prior to and following an 8 week course of Carbimazole therapy in an attempt to understand the mechanism by which the drug acts on the immune system. In untreated Graves' patients IL2R levels were elevated and IL2 levels reduced. Free radical scavengers were also reduced in these patients. Following treatment IL2R levels fell and IL2 levels rose. Levels of the free radical scanvengers also rose. It is not clear whether it is the fall in IL2R levels or the rise in the level of free radical scavengers (implying a reduction in free radical activity) which is responsible for the rise in IL2.
Wilson
R
R
University Department of Medicine, Glasgow Royal Infirmary.
McKillop
J H
JH
Buchanan
L M
LM
Bradley
H
H
Smith
W E
WE
Thomson
J A
JA
D002231:Carbimazole / Q000627:therapeutic use*; D002478:Cells, Cultured; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D016166:Free Radical Scavengers; D005978:Glutathione / Q000032:analysis / Q000097:blood; D006111:Graves Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis*; D008297:Male; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D013482:Superoxide Dismutase / Q000032:analysis*
D016166:Free Radical Scavengers; D007376:Interleukin-2; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2; D002231:Carbimazole; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005978:Glutathione