Ethane 1-hydroxy-1, 1-diphosphonate (EHDP) counteracts the inhibitory effect of uranyl nitrate on bone formation.
The beneficial effect of ethane 1-hydroxy-1, 1-diphosphonate (EHDP) in restoring the inhibition of bone formation in cases of acute uranium intoxication is presented. Bone formation was studied histomorphometrically in a model of alveolar bone healing. After tooth extraction, 40 rats were divided into 4 groups that received (1) no further treatment, (2) 10 daily intraperitoneal injections of 7.5 mg/kg of body weight of EHDP, (3) an intraperitoneal injection of 2.0 mg/kg of body weight of uranyl nitrate, and (4) the same treatment as was provided rats in groups 2 and 3. The results showed that the healing of bone did not occur in exposed animals, whereas healing in EHDP-treated exposed animals did not differ from that of nonexposed controls. This effect might result from a blocking and/or competitive action of EHDP and/or the stimulation that EHDP elicits at the doses and in the administration period studied.
Ubios
A M
AM
Faculty of Dentistry, University of Buenos Aires, Argentina.
Guglielmotti
M B
MB
Cabrini
R L
RL
D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D001861:Bone Regeneration; D004195:Disease Models, Animal; D012968:Etidronic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014502:Uranyl Nitrate / Q000008:administration & dosage / Q000506:poisoning*
D014502:Uranyl Nitrate; D012968:Etidronic Acid