[The cardiac toxicity of antidepressive thymoleptics. Experimental and clinical studies].
The aim of the present review was: 1) to analyse the effects of tricyclic antidepressant compounds on the conduction system of the heart, the heart rate, the left ventricular function and the blood pressure; 2) to describe the methods used in order to evaluate these parameters both in vitro and in vivo; 3) to summarize all the data available on cardiovascular side effects of the newer antidepressants.
Marino
A
A
Istituto di Farmacologia Sperimentale e Clinica, II Facoltà di Medicina e Chirurgia, Università di Napoli.
Schettini
G
G
Ventra
C
C
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic
Cardiotossicità da timolettici antidepressivi. Studi sperimentali e clinici.