title: Single-dose radiation therapy for prevention of heterotopic ossification after total hip arthroplasty.
abstract: Single-dose radiation therapy was prospectively evaluated for its efficacy in prevention of heterotopic ossification in patients at high risk after total hip arthroplasty. Thirty-one patients (34 hips) were treated between 1981 and 1988. Risk factors for inclusion in the protocol included prior evidence of heterotopic ossification, ankylosing spondylitis, and diffuse idiopathic skeletal hyperostosis. Patients with hypertrophic osteoarthritis or traumatic arthritis with osteophytes were not included. Operations on 34 hips included 19 primary total and 11 revision total hip arthroplasties and 4 excisions of heterotopic ossification. All patients received radiotherapy to the hip after operation with a single dose of 700 centigray. Radiotherapy is recommended on the first postoperative day. After this single-dose radiation treatment, no patient had clinically significant heterotopic ossification. Recurrent disease developed in two hips (6%), as seen on radiography (grades 2 and 3). This series documents a 100% clinical success rate and a 94% radiographic success rate in preventing heterotopic ossification in patients at high risk after total hip arthroplasty. Single-dose radiotherapy is as effective as other radiation protocols in preventing heterotopic ossification after total hip arthroplasty. It is less expensive and easier to administer than multidose radiotherapy.
authors: Department of Orthopaedic Surgery, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
authors: W L
authors: WL
authors: Healy
authors: T C
authors: TC
authors: Lo
authors: D J
authors: DJ
authors: Covall
authors: B A
authors: BA
authors: Pfeifer
authors: S A
authors: SA
authors: Wasilewski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006621:Hip Joint / Q000473:pathology* / Q000528:radiation effects; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control / Q000532:radiotherapy*; D011446:Prospective Studies; D011829:Radiation Dosage; D012086:Reoperation; D012307:Risk Factors