title: Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat.
abstract: Here we have explored whether dopamine is able to modulate the release of gamma-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 microM) the depolarization-induced release of [3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals.
authors: Department of Physiology, Biophysics and Neurosciences, Instituto Politecnico Nacional, Mexico, D.F.
authors: B
authors: B
authors: Floran
authors: J
authors: J
authors: Aceves
authors: A
authors: A
authors: Sierra
authors: D
authors: D
authors: Martinez-Fong
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000502:physiology*; D001552:Benzazepines / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology*; D005917:Globus Pallidus / Q000187:drug effects / Q000502:physiology; D006892:Hydroxydopamines; D066298:In Vitro Techniques; D008297:Male; D016627:Oxidopamine; D011699:Putamen / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017447:Receptors, Dopamine D1; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D001552:Benzazepines; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D005680:gamma-Aminobutyric Acid; D013469:Sulpiride; D016627:Oxidopamine; D004298:Dopamine