Immunohistochemical examination of Peyer's patches in senescence-accelerated mice.
The distribution of T cells, B cells and murine senile amyloid protein in Peyer's Patches was examined in senescence accelerated (SAM-P/1) and control (SAM-R/1) mice ranging in age from two to ten months. An immunohistochemical detection of lymphocyte surface antigens of T cells and B cells. A murine senile amyloid protein in Peyer's patches was detected by immunohistochemical staining with the specific antiserum. Congo red staining and electron microscopy. The T cell population increased and B cell population decreased slightly with age in SAM-P/1 mice, but little change was observed with age in SAM-R/1 mice. Murine senile amyloid protein positive spots were seen surrounding the vessels of the thymus-dependent area at 6 months of age, and were observed throughout the Peyer's patches at 10 months of age, but were not observed by 10 months of age in SAM-R/1 mice.
Yoshioka
H
H
Department of Geriatric Medicine, Kyoto University Hospital, Japan.
Takeda
T
T
Higuchi
K
K
Ohshio
G
G
Miyake
T
T
Sugiyama
T
T
Kita
T
T
D000375:Aging / Q000235:genetics / Q000276:immunology*; D000682:Amyloid / Q000032:analysis; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010581:Peyer's Patches / Q000276:immunology* / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000276:immunology*
D000682:Amyloid; D000954:Antigens, Surface; D007075:Immunoglobulin M