[Short and medium term evaluation of captopril-ketanserin combination in mild to moderate arterial hypertension].
Forty patients with mild-to-moderate arterial hypertension were randomized for double-blind treatment with ketanserin (20 mg b.i.d.) vs. captopril (25 mg b.i.d.) for fifteen days. Diastolic pressure was normalized (less than 90 mmHg) in 11 out of 20 patients of both groups. Of the 18 patients not responding to monotherapy, 17 were treated for 45 days with a combination of both drugs at the same dosages. Diastolic blood pressure was normalized in 15 out of these 17, and in one patient it was reduced by more than 10%. Thus the success rate of therapy was 94%.
Terrachini
V
V
Cattedra di Malattie dell'Apparato Cardiovascolare, Università degli Studi di Genova.
Provinciali
L
L
Barbara
C
C
Masperone
M A
MA
Zanna
C
C
Romeo
M
M
Bruzzone
F
F
Canale
C
C
D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
D007650:Ketanserin; D002216:Captopril
Valutazione a corto-medio termine dell'associazione captopril-ketanserina nell'ipertensione arteriosa lieve-moderata.