[Platelet labelling with In-111-oxine: platelet survival and the images].
We studied 10 male and 2 female normal non-smoker volunteers (mean age 25) by labeling of autologous platelets with 111-In oxine. Daily samples for platelet survival were obtained in all, gamma-camera images in 10 and blood pool digital subtraction with 99m-Tc labeled erythrocytes in 6. Mean platelet count was 594 +/- 235 10(3)/mm3; collagen platelet aggregation pre and post labeling was 74 +/- 4.8 and 70 +/- 10%, respectively. Mean labeling efficacy was 65 +/- 15.4%, mean labeling dose was 201 +/- 79.5 microCi. A linearized initial survival of 7.9 +/- 1 day was obtained. Scintigraphic images showed circulating activity, greater in the spleen, persisting after digital subtraction. The method described can be used for clinical evaluation of platelet disorders and thrombosis.
Conte
G
G
Servicio de Hematología, Hospital Clínico Universidad de Chile, Santiago.
González
P
P
Larraín
C
C
Olea
E
E
Parada
X
X
Hurtado
E
E
Cuneo
M
M
D000328:Adult; D001792:Blood Platelets / Q000000981:diagnostic imaging*; D002470:Cell Survival / Q000528:radiation effects; D004912:Erythrocytes / Q000000981:diagnostic imaging; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007205:Indium Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives*; D010976:Platelet Count / Q000528:radiation effects; D011877:Radionuclide Imaging; D013667:Technetium; D013997:Time Factors
D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline; D013667:Technetium
Marcación de plaquetas con In-111-oxina: sobrevida plaquetaria e imágenes.