Plasma level of atrial natriuretic peptide in renal venous blood--marker of kidney ischemia?
In 12 patients with unilateral significant renal ischemia plasma levels of atrial natriuretic peptide (ANP) were estimated in renal vein blood of the ischemic (IK) and contralateral kidney (NK) and in arterial blood under supine and upright conditions. Plasma ANP levels in renal vein blood were compared with plasma renin activity (PRA) of the same blood samples. Plasma ANP levels in renal vein blood of the contralateral kidney (87 +/- 9 pg/ml) were significantly lower than in arterial blood (131 +/- 11 pg/ml) and renal vein blood of the ischemic kidney (139 +/- 16 pg/ml). In contrast plasma ANP concentrations in renal vein blood of the ischemic kidney were slightly or markedly higher than in arterial blood. A positive correlation was found between the ratio of plasma ANP in renal vein blood of the IK to that of the NK under supine condition and the respective ratio of PRA. Data presented in this paper suggest the presence of abnormal handling of ANP by an ischemic kidney and that plasma ANP levels in renal vein blood may be a marker of renal ischemia.
Wiecek
A
A
Department of Nephrology, Silesian School of Medicine, Katowice, Poland.
Kokot
F
F
Kuczera
M
M
Klin
M
M
Kiersztejn
M
M
D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood; D007511:Ischemia / Q000175:diagnosis*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011187:Posture; D012082:Renal Veins; D012083:Renin / Q000097:blood
D009320:Atrial Natriuretic Factor; D012083:Renin