Protein adsorption and cellular adhesion and activation on biomedical polymers.
The design and development of new biomedical polymers for clinical application in devices, prostheses, and artificial organs requires a basic and fundamental understanding of biological interactions with biomedical polymers. Efforts in our laboratory have been directed towards appreciating the humoral and cellular interactions which govern protein adsorption and cellular adhesion and activation on biomedical polymers. Information and data are presented on protein adsorption from whole human blood, complement activation and receptors, and monocyte/macrophage adhesion and activation with growth factor release. Supported by experimental evidence, concepts regarding protein/polymer, cell/polymer, cell/protein/polymer, and cell/cell interactions as they are related to in vivo events are presented.
Anderson
J M
JM
Institute of Pathology, Case Western Reserve University, Cleveland.
Bonfield
T L
TL
Ziats
N P
NP
D000327:Adsorption; D001672:Biocompatible Materials; D001798:Blood Proteins / Q000493:pharmacokinetics*; D002448:Cell Adhesion; D003167:Complement Activation; D004129:Dimethylpolysiloxanes; D006133:Growth Substances; D006801:Humans; D008262:Macrophage Activation; D011093:Polyethylene Terephthalates; D011095:Polyethylenes; D011108:Polymers; D011138:Polytetrafluoroethylene; D011951:Receptors, Complement; D012826:Silicone Elastomers; D012828:Silicones
D001672:Biocompatible Materials; D001798:Blood Proteins; D004129:Dimethylpolysiloxanes; D006133:Growth Substances; D011093:Polyethylene Terephthalates; D011095:Polyethylenes; D011108:Polymers; D011951:Receptors, Complement; D012826:Silicone Elastomers; D012828:Silicones; C013830:baysilon; D011138:Polytetrafluoroethylene