[Effect of a calcium inhibitor, verapamil, on the development of heterotopic ossifications. An experimental study in rats].
After division of the tendo achilles in rats heterotopic bone forms in the muscle and in the tendon stumps. Tenotomy was performed in 26 male rats. Thirteen received Verapamil (36 mm/Kg) for six days per week for five months, and the remainder were not given this drug. The onset of heterotopic ossification was monitored by monthly x-rays. After five months the animals were killed and the sectioned tendons examined microscopically. The radiographs had shown that the amount of ossification was less in rats treated with Verapamil. This was confirmed at microscopy, but examination of the sections under polarised light showed that the ratio of lamellar to woven bone was the same in the two groups. Verapamil appeared to reduce the amount of heterotopic bone formation but did not influence the substitution of woven by lamellar bone.
Duriez
J
J
Institut de Recherche sur les Maladies du Squelette, Institut Calot, Berck sur Mer, France.
Flautre
B
B
Blary
M C
MC
Duriez
R
R
D000125:Achilles Tendon / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery*; D000818:Animals; D006614:Hindlimb / Q000000981:diagnostic imaging; D008297:Male; D008859:Microscopy, Polarization; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil
Effet d'un inhibiteur calcique, le vérapamil, sur le développement des ossifications hétérotopiques. Etude expérimentale chez le rat.