title: [Liposomal polycarboxylic chelating agents for elimination of toxic metals from the body].
abstract: Experimental evidence is overviewed to show the efficacy of liposomal polycarboxylic acids in detoxication and elimination of radionuclides and toxic metals from animal organisms. It is shown that liposomal salt of ethylene diaminetetraacetic acid is retained by the organism for a longer time. The reported evidence indicates considerable advantages of liposomal diethylene triaminepentaacetic acid in elimination of mercury, cadmium, lead, gold, ytterbium, and plutonium from animal organisms (as compared to free acid forms). The liposomal diethylene triaminepentaacetic acid significantly reduced the general and specific cadmium toxicity of animals loaded with lethal doses of cadmium chloride. N,N'-bis-[2-hydroxybenzene]-ethylenediamine-N,N'-diacetic acid in the liposomal form considerably increased the iron elimination rate as compared to the chelating solution. A possibility is proposed on the use of diethylene triaminepentaacetic acid in the liposomal form for radionuclide and toxic metal elimination and carriage detection.
authors: G I
authors: GI
authors: Muzia
authors: V I
authors: VI
authors: Kulikov
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D002264:Carboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D002614:Chelating Agents; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004492:Edetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D004785:Environmental Pollutants / Q000506:poisoning*; D008081:Liposomes / Q000627:therapeutic use*; D008670:Metals / Q000506:poisoning*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats
chemical_list: D000085:Acetates; D000931:Antidotes; D002264:Carboxylic Acids; D002614:Chelating Agents; D004337:Drug Carriers; D004785:Environmental Pollutants; D008081:Liposomes; D008670:Metals; D004369:Pentetic Acid; D004492:Edetic Acid
vernacular_title: Liposomal'naia forma polikarbonovykh khelatiruiushchikh agentov dlia vydeleniia toksichnykh metallov iz organizma.