[Vascular-induced disorders of cerebral performance in the elderly. Long-term therapy with pentoxifylline and psychological mental training].
In a six-week placebo-controlled, randomized, in part double-blind, study, the effectiveness and tolerance of pentoxifylline was investigated in 120 elderly patients with incipient cerebrovascular disorders (OPS). In addition to group I (placebo) and group II (2 X 600 mg pentoxifylline/d), a third group of patients (III) was treated with pentoxifylline plus psychological training. In the two pentoxifylline groups, the mental performance increased to a greater extent than in the placebo group. Despite a tendential superiority of the pentoxifylline plus training group, there was no statistically significant difference between groups II and III. With respect to "state of health and behavior" (summed score of the SCAG), the placebo group revealed a deterioration as compared with improvements in II and III, the improvement being more pronounced in the latter. Such an evaluation was also obtained when the changes in all the variables were considered. It has thus been shown that pentoxifylline is suitable for the symptomatic treatment of organic brain syndrome, and that its positive therapeutic effect can be improved by a simultaneous mental training program.
Blume
J
J
Albert-Roussel GmbH, Wiesbaden.
Rühlmann
K U
KU
de la Haye
R
R
Rettig
K
K
Oltmer
G
G
D000368:Aged; D015161:Dementia, Multi-Infarct / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010431:Pentoxifylline / Q000008:administration & dosage*
D010431:Pentoxifylline
Vaskulär bedingte Hirnleistungsstörungen im Alter. Langzeittherapie mit Pentoxifyllin und psychologischem Lerntraining.