[Acetylcholine and the primary input of acupuncture sensation--influence of peripheral acetylcholine on the role of electroacupuncture analgesia].
In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats. The results indicated that: 1) The effect of electroacupuncture analgesia can be enhanced by subcutaneous injection of neostigmine which related to the dosage used. 2) The influence of electroacupuncture analgesia can be markedly inhibited by intraperitoneal injection of Hemicholine. 3) This influence of suppression by Hemicholine can be reversed at once when acetylcholine in combination with neostigmine was injected. But could not reverse by neostigmine alone. It suggested that the effect of electroacupuncture analgesia and the primary input of acupuncture sensation were significantly related to the level and content of ACh in periphery.
Guan
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X
Department of Neurobiology, Tongji Medical University, Wuhan.
Liang
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X
Liu
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X
D000109:Acetylcholine / Q000494:pharmacology / Q000502:physiology*; D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D006426:Hemicholinium 3; D009388:Neostigmine; D000109:Acetylcholine