Conscious atrial appendectomized rats have a blunted atrial natriuretic factor release to volume expansion but normal responses to other acute stimuli.
The release of atrial natriuretic factor (ANF) after various acute stimuli was studied in conscious chronic bilaterally atrial appendectomized (APP) rats. The response to acute volume expansion was markedly blunted (+67% v +357% in controls, P less than .01). However, the response to norepinephrine infusion was only moderately reduced (+107% v +212%, P less than .05) and the response to acute salt load was identical to that in normal controls (+148% v +180%, P = NS). These results demonstrate that APP rats can increase the secretion of ANF, at least to some acute stimuli. This indicates that the stores of ANF available for release are not significantly depleted after atrial appendectomy.
Hoffman
A
A
National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
Keiser
H R
HR
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000502:physiology*; D003243:Consciousness; D005069:Evaluation Studies as Topic; D006325:Heart Atria / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D009638:Norepinephrine / Q000493:pharmacokinetics; D051381:Rats; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000493:pharmacokinetics
D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine