The atrial natriuretic factor hormonal system in the regulation of sodium excretion in dogs with experimental heart failure.
In response to a meat meal containing 125 mEq of sodium, conscious dogs (n = 5) with an arteriovenous (AV) fistula and chronic compensated heart failure exhibited temporally related increases in postprandial plasma immunoreactive atrial natriuretic factor (iANF), right atrial pressure, and sodium excretion. In separate experiments, two weeks of dietary sodium restriction produced similar marked stimulation of renin and aldosterone both in normal dogs (n = 5), and in AV fistula dogs (n = 5) with chronic high circulating levels of ANF. Plasma iANF did not change (P greater than .05) in either group. These results suggest that the ANF system is involved in the postprandial regulation of sodium excretion in the AV fistula dogs with compensated heart failure. In the postabsorptive state, however, the activity of the renin-aldosterone axis is closely related to dietary sodium intake and appears to function independently of the ANF system for the prevention of sodium loss.
Villarreal
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Department of Physiology, University of Missouri School of Medicine, Columbia 65212.
Freeman
R H
RH
D000450:Aldosterone / Q000097:blood; D000818:Animals; D001164:Arteriovenous Fistula / Q000097:blood / Q000503:physiopathology / Q000652:urine; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology; D002303:Cardiac Output, Low / Q000097:blood / Q000652:urine*; D004285:Dogs; D005260:Female; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology / Q000652:urine*; D012982:Sodium, Dietary / Q000009:adverse effects
D012982:Sodium, Dietary; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin