[Evaluation of the effectiveness of sodium piperacillin in the treatment of surgical infections in children].
A clinical trial has been carried out in 40 children (age ranging from 2 to 12 years) with postsurgical infections caused by aerobic, anaerobic and facultative bacteria. All have been treated by monotherapy with sodium piperacillin, with doses of 150-200 mg/kg daily in 3 administrations. The drug was administered for a mean period of 7 days, by intravenous infusion or intramuscular route. The causative organism was eradicated in all but 4 cases (90%). Side effects observed were all of mild intensity, and in no case it was necessary to discontinue the treatment with the drug. Both bacterial and clinical results indicate a high tolerability and a very rapid effectiveness of this antibiotic.
Inserra
A
A
Istituto di Ricerca Scientifica, Ospedale Pediatrico Bambin Gesù di Roma.
Serventi
P
P
Ciprandi
G
G
Spagnoli
A
A
Cristini
S
S
Boglino
C
C
D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010878:Piperacillin / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*
D010878:Piperacillin
Valutazione dell'efficacia della piperacillina sodica nel trattamento delle infezioni chirurgiche pediatriche.