[Intragonadal control of testicular function by neurohypophyseal-like peptides].
Immunochemical studies associated with physicochemical procedures led to demonstrate the presence of neurohypophysial-like peptides in the testis of numerous species including human. Characterization of arginine-vasopressin-neurophysin II mRNA and oxytocin-neurophysin I mRNA in rat testicular extracts is in favour of a local production for these peptides. The in vitro and in vivo evidences of a direct regulation of testicular steroidogenesis bg AVP and related peptides--the identification of specific AVP receptors on purified Leydig cells and their alteration in some physiological or pathological situations argue for a paracrine/autocrine role of these neurohypophysial-like-peptides in modulating Leydig cell androgen biosynthesis.
Pointis
G
G
Laboratoire d'Endocrinologie et de Biologie de la Reproduction, UFR Santé Médecine Biologie Humaine, Bobigny.
Tahri-Joutei
A
A
D000818:Animals; D001127:Arginine Vasopressin / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D007985:Leydig Cells / Q000502:physiology; D008297:Male; D051379:Mice; D010121:Oxytocin / Q000737:chemistry* / Q000502:physiology; D051381:Rats; D011979:Receptors, Pituitary Hormone / Q000502:physiology; D013737:Testis / Q000737:chemistry* / Q000502:physiology
D011979:Receptors, Pituitary Hormone; D001127:Arginine Vasopressin; D010121:Oxytocin
Contrôle intragonadique de la fonction testiculaire par les peptides de type neurohyphysaire.