[Synthesis and antibacterial activity of 1-substituted benzyl quinolone acid derivatives].
The compounds of quinolone class, which were studied extensively and developed very quickly in the last decades, showed high activity, low toxicity and broad antibacterial spectrum. About thirty new compounds of 1,7-disubstituted-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acids were synthesised and evaluated in vitro against S. aureus 25923, E. coli-25922 and P. aeruginosa. Their activities were low. The minimum inhibitory concentrations (MIC microgram/ml) of these compounds against Gram-positive bacteria were higher than those against Gram-negative bacteria. The relative in vitro activity contributed by 1-benzyl was: benzyl greater than p-chlorobenzyl greater than p-nitrobenzyl groups.
Zhou
S Q
SQ
Department of Medicinal Chemistry, Nanjing Institute of Materia Medica.
Zhu
C Q
CQ
Wu
G P
GP
Peng
S X
SX
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D042462:4-Quinolones; D000890:Anti-Infective Agents