title: Improved prognosis of fulminant hepatic failure (FHF) after plasma derivative replacement therapy. Enhanced proteolysis of hemostatic proteins confirmed by proteinase-inhibitor complexes determination.
abstract: In fulminant hepatic failure disturbances of blood coagulation are caused by both delayed synthesis and increased consumption of hemostatic proteins. The enhanced turnover of clotting factors and inhibitors may be induced by thrombin and plasmin after activation of the coagulation system by thromboplastic material and activators of plasminogen released from necrotic liver cells. Additionally, proteases such as elastase released from granulocytes, may be involved when infectious complications occur. The immunologic determination of the specific proteinase-inhibitor complexes thrombin-antithrombin III, plasmin-alpha 2 antiplasmin, and elastase-alpha 1 antitrypsin is of great diagnostic value to verify and differentiate the proteolysis of hemostatic proteins. Five patients with FHF were treated with plasma derivatives (FFP and AT III concentrates) until the liver had recovered and resumed synthesis of clotting factors and their inhibitors. The coagulation parameters normalized, bleeding complications and microcirculatory failure could be prevented. The data suggest that a comprehensive substitution of plasma components improves considerably the prognosis of acute liver failure.
authors: Department of Hematology/Oncology, Phillipps-University of Marburg, FRG.
authors: R
authors: R
authors: Egbring
authors: R
authors: R
authors: Seitz
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000378:metabolism; D000990:Antithrombin III / Q000008:administration & dosage* / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000201:enzymology / Q000628:therapy*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000628:therapy; D056486:Chemical and Drug Induced Liver Injury / Q000628:therapy; D003131:Combined Modality Therapy; D010450:Endopeptidases / Q000097:blood*; D005176:Factor XIII / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D006501:Hepatic Encephalopathy / Q000201:enzymology / Q000628:therapy*; D006801:Humans; D019272:Leukocyte Elastase; D008297:Male; D010196:Pancreatic Elastase / Q000097:blood / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D010949:Plasma; D011480:Protease Inhibitors / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000979:alpha-2-Antiplasmin
chemical_list: D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; C037741:alpha 1-antitrypsin-leukocyte elastase complex; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C037742:plasmin-plasmin inhibitor complex; D000990:Antithrombin III; D005176:Factor XIII; D010450:Endopeptidases; D010447:Peptide Hydrolases; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D005341:Fibrinolysin