The effect of guanethidine-induced denervation of the peripheral sympathetic nervous system on the onset of puberty in female rats.
Intraperitoneal injection of guanethidine (50 mg kg-1 day-1) in newborn rats produces complete and permanent sympathectomy. The present study was performed to evaluate the effect of this form of denervation on the onset of puberty in female rats. Treatment began 7 days after birth and was maintained for 3 weeks. On the 45th day, animals were killed by decapitation and plasma LH and FSH levels were measured. Based on the day of vaginal opening (puberty index), the results show that guanethidine induces a delay in the onset of puberty. The concentrations of LH and FSH in the plasma were not statistically different from those in control rats.
Albuquerque-Araújo
W I
WI
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Rosa-e-Silva
A A
AA
Franci
J A
JA
Favaretto
A L
AL
Antunes-Rodrigues
J
J
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006145:Guanethidine; D007986:Luteinizing Hormone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000187:drug effects*; D013563:Sympathectomy, Chemical
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006145:Guanethidine