[T-lymphocyte subpopulations in the peripheral blood of patients with Crohn disease].
Immunological disorders seem to be of considerable relevance to the pathogenesis of Crohn's disease (CD). T-cells play a central role in immunoregulation. The T-cell subpopulations of 70 patients with CD were compared to those of age- and sex-matched healthy controls. The suppressor-inducer subpopulations were found to be reduced in CD patients irrespective of wether they were taking steroids or not. In contrast to other subpopulations suppressor-inducer cells remained unchanged during follow-up. The results point to a disturbance in the regulation of suppressor T-cells in patients with Crohn's disease.
Purrmann
J
J
Abteilung für Gastroenterologie, Heinrich-Heine-Universität, Düsseldorf.
Hengels
K J
KJ
Cleveland
S
S
Gemsa
R
R
Koldehoff
M
M
Strohmeyer
G
G
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000945:Antigens, Differentiation, T-Lymphocyte; D001379:Azathioprine
Subpopulationen von T-Lymphozyten im peripheren Blut bei Patienten mit M. Crohn.