Frequency of HLA genes and islet cell antibodies (ICA) and result of postpartum oral glucose tolerance tests (OGTT) in Saudi Arabian women with abnormal OGTT during pregnancy.
A consecutive series of 55 Saudi women with abnormal 75 g oral glucose tolerance test (OGTT) during pregnancy was reinvestigated 2-4 months after delivery. A 75 g OGTT was done and samples were also drawn for analysis of C-peptide concentration, islet cells antibodies (ICA) and HLA antigens. The results of these laboratory investigations and a number of patient characteristics were analyzed to identify risk factors for patients likely to have impaired OGTT after delivery. Twenty-five (45.5%) of the patients had an abnormal OGTT after delivery. The distribution of HLA antigen frequencies did not differ from a reference group of healthy Saudis. ICA were found in only one patient. Logistic regression analysis identified insulin treatment during pregnancy (p = 0.001) as the only factor to predict an abnormal OGTT after delivery.
Stangenberg
M
M
Department of Obstetrics and Gynecology, King Faisal Specialist, Hospital and Research Center, Riyadh, Saudi Arabia.
Agarwal
N
N
Rahman
F
F
Sheth
K
K
al Sedeiry
S
S
De Vol
E
E
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D016640:Diabetes, Gestational / Q000235:genetics / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005951:Glucose Tolerance Test; D006680:HLA Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D008285:Major Histocompatibility Complex; D011247:Pregnancy; D012016:Reference Values; D012044:Regression Analysis; D012529:Saudi Arabia
D001323:Autoantibodies; D006680:HLA Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; C024211:islet cell antibody