[The neurodegenerative and convulsant action of quinolinic acid].
Convulsant and neurodestructive action of intraventricular administration of quinolinic acid was studied in rats. It was found that severity of neurodegenerative changes in the hippocamp depended on the dose of that metabolite and correlated but slightly with the intensity of seizures. Destructions induced by quinolinic acid in the CNS did not change seizures induced by subsequent injections of the compound.
Kozlovskiĭ
V L
VL
Prakh'e
I V
IV
Geĭnisman
N V
NV
D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007276:Injections, Intraventricular; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects*; D009562:Nissl Bodies / Q000187:drug effects / Q000473:pathology; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000473:pathology
D003292:Convulsants; D011725:Pyridines; D011805:Quinolinic Acids; D017378:Quinolinic Acid
Neĭrodegenerativnoe i sudorozhnoe deĭstvie khinolinovoĭ kisloty.