Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension.
The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n = 11) or a regular-sodium diet (n = 10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.
Lattion
A L
AL
Division of Hypertension, University Hospital, Lausanne, Switzerland.
Flückiger
J P
JP
Waeber
B
B
Nussberger
J
J
Aubert
J F
JF
Brunner
H R
HR
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000235:genetics; D004039:Diet, Sodium-Restricted; D015870:Gene Expression; D006325:Heart Atria / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage* / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor; D012964:Sodium