[Immunologic classification of lymphoid cells based on the detection of membrane phenotype using monoclonal antibodies in patients with T-lymphoproliferative diseases].
A series of (CD1-CD10) mouse monoclonal antibodies reactive with human T lymphoid cells, in different stages of differentiation, was used for immunological classification of leukaemic cells of 25 patients with T cell lymphoproliferative disorders, using a fluorescence assay. The majority of patients with T-ALL had cells of an immature or early thymic phenotype and patients with T lymphoblastic lymphoma had phenotypes corresponding to different levels of more mature stages of T cell differentiation. Three patients with T-CLL and one patient with mycosis fungoides had mature T cell phenotypes CD3+, CD4-, CD8+, corresponding to cytotoxic/suppressor cell types and one patient with T-CLL had CD3+, CD4+, CD8- phenotype, corresponding to the "helper/inducer" cell type.
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Ustav hematologie a krevní transfúze Praha.
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D002648:Child; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000276:immunology*; D016131:Lymphocyte Subsets; D008875:Middle Aged
D015703:Antigens, CD
Imunologická klasifikace lymfoidních bunĕk nemocných s T-lymfoproliferativními chorobami zalozená na průkazu membránových fenotypů monoklonálními protilátkami.