[Serotonin receptor subtypes. Considerations on their physiological role and therapeutic prospects].
Recent evidence for the existence of different types and subtypes of serotoninergic receptors has been reviewed. Presently, 5-TH receptors have been divided into 5-HT1, 5-HT2 and 5-HT-3. 5-HT1 receptors have been subdivided into 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D. The development of specific agonists and antagonists to these different types of receptors suggests the possibility of a selective use of these drugs in the treatment of various disorders.
Di Renzo
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G
Istituto di Farmacologia Sperimentale e Clinica, II Facoltà di Medicina e Chirurgia dell'Università di Napoli.
Marino
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A
D015116:5,7-Dihydroxytryptamine / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002027:Bufotenin / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007650:Ketanserin / Q000627:therapeutic use; D051379:Mice; D011817:Rabbits; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis* / Q000502:physiology; D012702:Serotonin Antagonists / Q000378:metabolism / Q000627:therapeutic use*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D002027:Bufotenin; D015116:5,7-Dihydroxytryptamine; D007650:Ketanserin
Sottotipi recettoriali della serotonina. Considerazioni sul ruolo fisiologico e sulle prospettive terapeutiche.