Cloning of the mouse homologue of the yeast cell cycle control gene cdc2.
The cdc2 cell cycle control genes of yeast and man encode 34 kDa protein kinases. Using the human CDC2 gene as a DNA probe we have isolated cDNA clones corresponding to the mouse cdc2 gene. Sequencing of the mouse clones show 96% identity at the amino acid level to the human CDC2 gene and detects a 2 kb RNA product indistinguishable to that seen in human cells. The mouse gene should be useful in studying the functional control of the cell cycle in mouse cells.
Spurr
N K
NK
Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, Potters Bar, UK.
Gough
A C
AC
Lee
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D016203:CDC2 Protein Kinase / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D012568:Schizosaccharomyces / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D004247:DNA; D016203:CDC2 Protein Kinase