Plasminogen activators: pharmacology and therapy.
Biochemical advances are providing new insights into coagulation and fibrinolysis. Integrating this biochemical knowledge into plasminogen activator therapy improves understanding of currently available enzymes. Basic components of the fibrinolytic system are discussed and the chemical structures, pharmacokinetics, dosages, and modes of delivery of current and future plasminogen activators are reviewed.
Holden
R W
RW
Department of Radiology, Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis 46202.
D000933:Antifibrinolytic Agents / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005337:Fibrin / Q000378:metabolism / Q000502:physiology; D005341:Fibrinolysin / Q000378:metabolism / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D010958:Plasminogen / Q000378:metabolism / Q000502:physiology; D010960:Plasminogen Activators / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D015849:Plasminogen Inactivators / Q000378:metabolism
D000933:Antifibrinolytic Agents; D015849:Plasminogen Inactivators; D005337:Fibrin; D010958:Plasminogen; D010960:Plasminogen Activators; D005341:Fibrinolysin