Effects of humic acids, para-aminobenzoic acid and ascorbic acid on the N-nitrosation of the carbamate insecticide propoxur and on the mutagenicity of nitrosopropoxur.
Nitrosation of the carbamate insecticide propoxur at pH 3 and 37 degrees C was determined colorimetrically and found to be time- and sodium nitrite concentration-dependent. Nitrosated propoxur was mutagenic when exposed to the seeds of the higher plant Arabidopsis thaliana but the formation of nitrosopropoxur, the presumed mutagen, was inhibited by humic acids, para-aminobenzoic acid and ascorbic acid. These agents also reduced the mutagenicity of preformed nitrosopropoxur.
Gichner
T
T
Institute of Experimental Botany, Prague, Czechoslovakia.
Badaev
S A
SA
Pospísil
F
F
Velemínský
J
J
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D006812:Humic Substances / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D015538:Nitrosation; D010944:Plants / Q000187:drug effects / Q000235:genetics; D001074:Propoxur / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*
D006812:Humic Substances; D009153:Mutagens; C063383:N-nitrosopropoxur; D001074:Propoxur; D001205:Ascorbic Acid; D010129:4-Aminobenzoic Acid