A model of the mechanisms of long-term potentiation in the hippocampus.
Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the NMDA-receptor channel, protein phosphorylation and protein turnover. The validity of the model is discussed based on the results of computer simulations.
Kitajima
T
T
Faculty of Engineering, Yamagata University, Japan.
Hara
K
K
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D003491:Cybernetics; D004558:Electric Stimulation; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology*; D008959:Models, Neurological; D011494:Protein Kinases / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate; D011494:Protein Kinases; D002118:Calcium