[Immunogenic properties of the liposomal form of Pseudomonas aeruginosa anatoxin].
Studies of immunogenic properties of P. aeruginosa anatoxin incorporated into liposomes of varying lipid compositions have shown that single immunization of mice with the anatoxin included into phosphatidyl ethanolamine and lecithin cholesterol liposomes induces a 6-8-fold higher antitoxin antibodies production than immunization with unadsorbed or adsorbed on aluminum hydroxide P. aeruginosa toxoid. The maximal production of antibodies against exotoxin A of P. aeruginosa is observed already on the 14th day. The adjuvant properties of lecithin-cholesterol liposomes were revealed only in the primary immune response, while phosphatidyl ethanolamine-containing liposomes exhibited the capacity for enhancing both the primary and the secondary immune responses. The use of liposomal P. aeruginosa anatoxin made of lipids varying in composition and charge is a promising trend of research aimed at designing new highly effective immunization preparations for P. aeruginosa infection prevention.
Minukhin
V V
VV
Brodinova
N S
NS
Tsyganenko
A Ia
AIa
Ivanova
N N
NN
Vasil'chenko
V N
VN
Sennikov
G A
GA
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis; D002784:Cholesterol / Q000008:administration & dosage; D007114:Immunization / Q000379:methods*; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D010713:Phosphatidylcholines / Q000008:administration & dosage; D010714:Phosphatidylethanolamines / Q000008:administration & dosage; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D014121:Toxoids / Q000008:administration & dosage* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D014121:Toxoids; D002784:Cholesterol
Immunogennye svoĭstva liposomal'noĭ formy anatoksina sinegnoĭnoĭ palochki.