title: Headache in acromegaly: dramatic improvement with the somatostatin analogue SMS 201-995.
abstract: Two acromegalic patients with severe headache, persisting after pituitary adenomectomy followed by radiotherapy in one, were treated with the somatostatin analogue SMS 201-995. Both had been resistant to conventional headache therapy and experienced dramatic and rapid relief after the first injection of the analogue. This result persisted with long-term treatment of the drug. Although the mechanism of action of SMS 201-995 in pain remains unclear, the rapid and efficacious analgesic effect of this compound may be one more indication for its use in pituitary tumors associated with cephalalgias.
authors: Division of Functional Neurosurgery, Hospital das Clínicas, University of Sao Paulo Medical School, Brazil.
authors: N R
authors: NR
authors: Musolino
authors: R
authors: R
authors: Marino Júnior
authors: M D
authors: MD
authors: Bronstein
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000236:Adenoma / Q000150:complications / Q000601:surgery; D000293:Adolescent; D000328:Adult; D006261:Headache / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D010147:Pain Measurement; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery
chemical_list: D015282:Octreotide