Interventional cardiovascular therapy by laser and thermal angioplasty.
The advent of balloon angioplasty as a clinical device crystallized the concept of nonsurgical revascularization. The problems of restenosis, diffuse disease, and total occlusions persist despite the demonstrated efficacy of balloon angioplasty. During the past 5 years, a variety of laser devices and catheter designs have demonstrated usefulness in the treatment of peripheral vascular disease. Initial success rates of 70-90% have been reported in occluded femoropopliteal arteries. Further clinical trials are warranted to compare the relative efficacy of these devices with each other and conventional therapies. Thermal ablative devices have not yet shown great promise for treatment of coronary disease. Modified versions of these devices as well as nonthermally acting excimer lasers are promising as clinical tools for enhancing our ability to nonsurgically revascularize patients, and trials with these devices are now underway.
Litvack
F
F
Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine 90048.
Grundfest
W S
WS
Segalowitz
J
J
Papaioanniou
T
T
Goldenberg
T
T
Laudenslager
J
J
Hestrin
L
L
Forrester
J S
JS
Eigler
N A
NA
Cook
S
S
D000792:Angiography; D000800:Angioplasty, Balloon / Q000295:instrumentation; D000818:Animals; D001158:Arteries / Q000528:radiation effects; D002318:Cardiovascular Diseases / Q000601:surgery / Q000628:therapy*; D002404:Catheterization / Q000379:methods; D004867:Equipment Design; D005336:Fiber Optic Technology; D005453:Fluorescence; D006358:Hot Temperature; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation; D007834:Lasers