Relation of alpha and gamma interferon levels to development of AIDS in homosexual men.
Homosexual men who were human immunodeficiency virus (HIV) seropositive at enrollment into the Pittsburgh portion of the Multicenter AIDS Cohort Study had elevated titers of serum alpha and gamma interferon (IFN) within 24 months prior to development of AIDS. In contrast, subjects who developed AIDS relatively early after seroconversion to HIV during this study did not have increased levels of alpha or gamma IFN.
Rinaldo
C R
CR
Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261.
Armstrong
J A
JA
Kingsley
L A
LA
Zhou
S
S
Ho
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D011863:Radioimmunoassay; D013601:T-Lymphocytes
D007370:Interferon Type I; D007371:Interferon-gamma