[Somatomedin, growth and nutritional status].
Serum somatomedins, or insulin-like growth factor(s) (IGF), originally characterized as primarily GH-dependent peptides, were found to also be dependent on insulin levels and nutritional status. Four properties characterize somatomedin peptides: their concentrations in serum are growth hormone dependent; they possess insulin actions in extraskeletal tissues; they promote the incorporation of sulfate into proteoglycans of cartilage; and they stimulate DNA synthesis and cell multiplication in certain types of cultured cells. Reduced somatomedin C levels are found in children with severe protein-energy malnutrition. Plasma concentration of growth hormone and cortisol are both elevated and there are low levels of insulin and somatomedin C. There is evidence that the ability of somatomedin C to stimulate cartilage is modulated by somatomedin inhibitor, factor that may act to limit growth in conditions of hormonal and/or nutritional deficiency. Dietary energy and protein appears to be particularly important for both generation of somatomedins and their action on growing cartilage. Measurement of somatomedins C concentration shows promise as a means for monitoring the response of malnourished patients and rats to nutrition repletion.
Tirapegui
J O
JO
Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São, Paulo.
Cardoso
M A
MA
Callegaro
M da G
Mda G
D000818:Animals; D004044:Dietary Proteins / Q000494:pharmacology; D006128:Growth; D006801:Humans; D009752:Nutritional Status; D011502:Protein-Energy Malnutrition / Q000097:blood; D051381:Rats; D013002:Somatomedins / Q000378:metabolism* / Q000502:physiology
D004044:Dietary Proteins; D013002:Somatomedins
Somatomedina, crescimento e estado nutricional.