The synergism of gamma-interferon and tumor necrosis factor in whole body hyperthermia.
It is suggested that gamma-interferon (gamma-IFN) can be added to tumor necrosis factor (TNF) to improve therapy in whole body hyperthermia (WBH). The amount of r-HTNF is about 3.5 x 10(6) units per week with about 3.5 x 10(4) units of rH gamma-INF intravenously. The body temperature should be 40 degrees C for one half hour. An i.p. injection of secobarbital (24 mg/kg) should be given as well.
Rosen
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Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
D003131:Combined Modality Therapy; D004357:Drug Synergism; D006801:Humans; D006979:Hyperthermia, Induced; D007371:Interferon-gamma / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma