Formyl-methanofuran synthesis in Methanobacterium thermoautotrophicum.
The initial step of methanogenesis from CO2 is the formation of formyl-methanofuran (formyl-MFR) from methanofuran (MFR), CO2 and H2. The enzymology of this novel type of CO2 fixation reaction has been difficult to study because formyl-MFR synthesis is subject to a complex activation. Recently, however, a number of advances have made questions regarding formyl-MFR synthesis more approachable.
Bobik
T A
TA
Department of Microbiology, University of Illinois, Urbana 61801.
DiMarco
A A
AA
Wolfe
R S
RS
D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D004579:Electron Transport; D019605:Euryarchaeota / Q000201:enzymology / Q000378:metabolism*; D005663:Furans / Q000378:metabolism*
D005663:Furans; D002245:Carbon Dioxide; C050842:formylmethanofuran; D000445:Aldehyde Oxidoreductases; C060639:formylmethanofuran dehydrogenase