Light-induced infrared light scattering signal in the retina: effect of phosphodiesterase inhibitors.
Visible light changes IR light scatter through a toad retina. This signal presents three components: at low light intensity (100-400 bleached rhodopsins/rod) an early decrease in IR light scatter, of small amplitude, with time to peak of 1-6 s; at intermediate light intensity (1200-16,000 bleached rhodopsins/rod) a slow increase in IR light scatter, with time to peak of 10-30 s; at high light intensity (50,000-160,000 bleached rhodopsins/rod) a last increase in IR light scatter, with time to peak of 1 min. Light sensitivity, amplitude and time to peak of the last two components are increased by inhibitors (3-isobutyl-1-methyl-xanthine and papaverine) of the cyclic 3'5' guanosine monophosphate phosphodiesterase.
Stein
P J
PJ
Department of Ophthalmology and Visual Science, Yale University Medical School, New Haven, CT 06510.
Caretta
A
A
D000221:Adaptation, Ocular / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D002024:Bufo marinus; D007259:Infrared Rays; D008027:Light; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000528:radiation effects*; D012542:Scattering, Radiation
D010726:Phosphodiesterase Inhibitors