title: Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S.
abstract: Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.
authors: Department of Neurology, Indiana University School of Medicine, Indianapolis.
authors: K L
authors: KL
authors: Roos
authors: R M
authors: RM
authors: Pascuzzi
authors: M A
authors: MA
authors: Kuharik
authors: A D
authors: AD
authors: Shapiro
authors: M J
authors: MJ
authors: Manco-Johnson
mesh_terms: D000293:Adolescent; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D011247:Pregnancy; D011486:Protein C / Q000378:metabolism*; D017293:Protein S; D011644:Puerperal Disorders / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D012851:Sinus Thrombosis, Intracranial / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D006023:Glycoproteins; D011486:Protein C; D017293:Protein S