title: Changes in plasma concentrations of atrial natriuretic peptide during exchange transfusion in premature infants.
abstract: Plasma concentrations of atrial natriuretic peptide (ANP) and hemodynamic parameters were investigated in five premature infants undergoing exchange transfusion. Baseline values of ANP were 51.7 +/- 21.2 fmol/ml. Volume depletion by withdrawal of 10 ml blood did not cause changes in systolic blood pressure (79.4 +/- 4.3 vs. 71.4 +/- 5.6 mmHg) and heart rate (115 +/- 5.2 vs. 115 +/- 2.4 b/min). ANP levels in plasma remained unaltered (53.4 +/- 24.9 fmol/ml). Replacement of 10 ml blood increased central venous pressure by 33% and ANP concentration in the plasma by nearly 30%, while heart rate and blood pressure remained unchanged. Our data indicate that the heart of the premature infant responded to acute blood replacement with increased ANP-release, while blood removal appeared not to influence hormone regulation.
authors: 1st Department of Paediatrics, Semmelweis University, Budapest, Hungary.
authors: A
authors: A
authors: Khoór
authors: T
authors: T
authors: Tulassay
authors: M
authors: M
authors: Bald
authors: W
authors: W
authors: Rascher
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001804:Blood Transfusion, Autologous / Q000379:methods*; D002496:Central Venous Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male
chemical_list: D009320:Atrial Natriuretic Factor