Impaired prolactin response to hyperthermia in heroin addicts.
The response of PRL, FSH and LH to sauna-induced hyperthermia was examined in 8 male former heroin addicts (studied after 14-24 days of abstinence) and 8 age- and sex-matched control subjects. The basal levels of PRL tended to be higher in former drug users than in control subjects (p = 0.07). After sauna, there were no changes in the addict group, whereas a significant increase was observed in normal subjects (p less than 0.001). Baseline plasma LH and FSH levels were significantly lower in former drug users (p = 0.02), but no change was found after sauna in either group. These findings are consistent with the existence of a deficient adaptation to thermal stress in chronic drug users, even after a relatively short drug-free period.
Vescovi
P P
PP
Istituto di Clinica Medica Generale e Terapia Medica, University of Parma, Italy.
Pedrazzoni
M
M
Maninetti
L
L
Pioli
G
G
Gerra
G
G
Passeri
M
M
D000293:Adolescent; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006556:Heroin Dependence / Q000503:physiopathology*; D006358:Hot Temperature; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood*; D029002:Steam Bath
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone