[Occlusive therapy of psoriasis--comparison of clinical effectiveness of short-term and prolonged use].
In an open clinical trial on stationary psoriatic plaques, we compared the effects of shortime occlusive (SO) dressing (24h) and prolonged occlusion (PO: 5-28 days). IN SO, Weinstein's index decreased from 7.3 +/- 1.7 to 3.3 +/- 1.8 (n = 21), in PO from 6.5 +/- 1.1 to 3.7 +/- 1.7 (n = 15). The results were even better in cases with optimal PO dressing (decrease from 6.8 +/- 1.4 to 2.5 +/- 0.9). The most important side effects were itching and exsudation with ensuing smell. In only one of the cases did the side effects cause a drop-out after 5 days. Regarding stationary psoriatic plaques on the extensor sides of the lower legs and forearms. We recommend continuous occlusive dressing for 8-10 days--either as an alternative mode of therapy, or as an intermediate regimen.
Wollina
U
U
Universitäts-Hautklinik Jena.
Knopf
B
B
Fünfstück
V
V
Geyer
A
A
Hempel
E
E
Simon
D
D
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D011565:Psoriasis / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000473:pathology
Okklusivtherapie der Psoriasis--Vergleich der klinischen Wirksamkeit von kurzzeitiger und prolongierter Anwendung.