title: Antithyroid and other organ-specific antibodies in Saudi Arab diabetic and normal children.
abstract: Sera from 162 Saudi Arab children were examined for autoantibodies to thyroid microsomes, thyroglobulin pancreatic islet cells, gastric parietal cells, and adrenocortical cells. The subjects included a control group (n = 76) and 86 children below 14 years with Type 1 diabetes. Antithyroid antibodies were detected in 8.1% of the diabetic group and in none of the control group. Parietal cell antibodies were found in 9.3% of the diabetic group and 4.4% of the control group; 14.6% of diabetic children and 2.2% of control children were positive for islet antibodies. However, 56.3% (9/16) of those who were tested at onset of diabetes had positive islet antibodies. In none of the children could we detect adrenocortical cell antibodies.
authors: Department of Pediatrics, College of Medicine, Riyadh, Saudi Arabia.
authors: M A
authors: MA
authors: Abdullah
authors: H
authors: H
authors: Salman
authors: H
authors: H
authors: Bahakim
authors: M O
authors: MO
authors: Gad al Rab
authors: K
authors: K
authors: Halim
authors: A
authors: A
authors: Abanamy
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D012016:Reference Values; D012529:Saudi Arabia; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C024211:islet cell antibody