[Folinic acid in the treatment of elderly patients with macrocytic anemia].
Thirty elderly patients suffering from macrocytic anaemia associated with chronic diseases were treated with folinic acid for 25 days at a dosage of 4-8 mg daily. For each patient routine laboratory tests have been carried out, the clinical parameters have been recorded at the beginning and at the end of the trial and after 8 days of treatment a possible reticulocyte crisis has been evaluated. The results showed a significant decrease of medium corpuscular volume (MCV), of mean corpuscular haemoglobin (MCH), of iron as well as an increase of folic acid in the serum. After 8 days of treatment a statistically significant reticulocyte crisis was observed.
Lucchi
R
R
IV Divisione di Medicina, Ospedale Estense, Modena.
Criserà
A
A
Ferrari
M G
MG
Sacchetta
A C
AC
D000368:Aged; D000369:Aged, 80 and over; D000748:Anemia, Macrocytic / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D002955:Leucovorin
L'acido folinico come terapia in pazienti anziani portatori di anemia macrocitica.