Hypercarbia versus hypocarbia in panic disorder.
In order to compare the panicogenic effects of hypercarbia and hypocarbia in panic disorder (PD), 12 PD patients and 11 healthy controls underwent a 35% CO2 challenge as well as a hyperventilation provocation test in a random cross-over design. Both anxiety and anxiety symptoms proved to be significantly higher during the 35% CO2 challenge in PD patients as compared to the response during 35% CO2 in normals and during hyperventilation in both patients and normals. The results suggest that PD patients are specifically hypersensitive to an increase in pCO2.
Zandbergen
J
J
State University of Limburg, Department of Clinical Psychiatry, Maastricht, The Netherlands.
Lousberg
H H
HH
Pols
H
H
de Loof
C
C
Griez
E J
EJ
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000503:physiopathology* / Q000523:psychology; D001143:Arousal / Q000502:physiology*; D002245:Carbon Dioxide / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010556:Personality Tests; D016032:Randomized Controlled Trials as Topic
D002245:Carbon Dioxide