Plagiarizing plants: amino sugars as a class of glycosidase inhibitors.
Many polyhydroxylated alkaloids from plants are specific inhibitors of glycosidases. Information about these has led to the development of a wide range of both naturally occurring and synthetic inhibitors which may be used for mechanistic studies and for the purification of these enzymes. Sugar lactones are starting materials for highly efficient syntheses of deoxymannojirimycin and deoxyfuconojirimycin and of a number of their iminoheptitol analogues. This has allowed an investigation of the relationship between mannosidase and fucosidase inhibition.
Fleet
G W
GW
Dyson Perrins Laboratory, Oxford University, UK.
Fellows
L E
LE
Winchester
B
B
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000606:Amino Sugars / Q000138:chemical synthesis / Q000737:chemistry*; D005944:Glucosamine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D050112:Imino Pyranoses; D015394:Molecular Structure; D018521:Plant Physiological Phenomena; D013402:Sugar Alcohols / Q000138:chemical synthesis
D000606:Amino Sugars; D050112:Imino Pyranoses; D013402:Sugar Alcohols; D017485:1-Deoxynojirimycin; C062662:deoxyfuconojirimycin; D006026:Glycoside Hydrolases; D005944:Glucosamine