Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations.
A tetracycline (doxycycline) was administered daily by oral intubation to adult diabetic rats to assess the effect on skeletal tissue; the rationale--osteopenia is a complication of diabetes and tetracyclines (TCs) were recently found to inhibit pathologic collagen loss (e.g. in diabetic rat skin) by a mechanism independent of their antimicrobial efficacy. Osteopenia was induced by streptozotocin-diabetes as indicated by physical (e.g. specific gravity), chemical (e.g. calcium (Ca) content) and ultrastructural characteristics of the femurs, and TC administration (including treatment with a chemically-modified non-antimicrobial analog) appeared to prevent the development of the bone deficiency disease without affecting the severity of hyperglycemia.
Golub
L M
LM
Dept. of Oral Biology and Pathology, School of Dental Medicine, S.U.N.Y., Stony Brook.
Ramamurthy
N S
NS
Kaneko
H
H
Sasaki
T
T
Rifkin
B
B
McNamara
T F
TF
D000284:Administration, Oral; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications*; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology; D005269:Femur / Q000648:ultrastructure; D006943:Hyperglycemia / Q000150:complications; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*
D013311:Streptozocin; D013752:Tetracycline; D004318:Doxycycline