title: Dual genotype in cutaneous T-cell lymphomas and pseudolymphomas.
abstract: Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patients contained a monoclonal T-cell population. In addition, DNA from 5 patients contained an immunoglobulin gene rearrangement. These results demonstrate that cutaneous T-cell lymphomas are clonal T-cell malignancies that frequently express a dual genotype, which may sometimes reflect the clonotypic heterogeneity of these disorders.
authors: Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, Clermont-Ferrand, France.
authors: Y J
authors: YJ
authors: Bignon
authors: P
authors: P
authors: Souteyrand
authors: H
authors: H
authors: Roger
authors: D
authors: D
authors: Bernard
authors: B
authors: B
authors: Dastugue
authors: F
authors: F
authors: Ramos
authors: M
authors: M
authors: d'Incan
authors: P
authors: P
authors: Chollet
authors: R
authors: R
authors: Plagne
mesh_terms: D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005838:Genotype; D006801:Humans; D007133:Immunoglobulin Joining Region / Q000235:genetics; D008223:Lymphoma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D013601:T-Lymphocytes
chemical_list: D007133:Immunoglobulin Joining Region