[Possible relationship between polyunsaturated fatty acids and signs of left ventricle hypertrophy].
In aborigines from the costal and continental areas of Chukotka who differ in dietary polyunsaturated fatty acid (PFA) n-3 intake, specific features of the composition of fatty acids in cell membranes were revealed in a model of erythrocytes: the costal inhabitants showed a higher proportion of PFA n-3 mainly through eicosapentaenic acid and lower proportion of major PFA n-6. With this, plasma lipoprotein lipids in whose composition the acids transported to the cell membranes displayed the similar regularities in changes in fatty acid composition. Only a far larger portion of eicosapentaenic acid in the cell membranes from the costal inhabitants than from the continental inhabitants was associated with greater mass of the left ventricular myocardium. It was concluded that transport of lipids containing high PFA n-3 in the composition of lipoproteins to the cell membranes caused an increase of the acids in them and, evidently, a change in physicochemical and, therefore, functional properties of cells.
Gerasimova
E N
EN
Perova
N V
NV
Ozerova
I N
IN
Kulakova
S N
SN
Levachev
M M
MM
Shal'nova
S A
SA
Astakhova
T I
TI
Riabikov
A N
AN
Kuznetsov
V A
VA
Iadryshnikova
E K
EK
D000328:Adult; D006332:Cardiomegaly / Q000209:etiology*; D002849:Chromatography, Gas; D004032:Diet; D015118:Eicosapentaenoic Acid / Q000097:blood; D004910:Erythrocyte Membrane / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
D005231:Fatty Acids, Unsaturated; D008055:Lipids; D015118:Eicosapentaenoic Acid
Vozmozhnaia sviaz' polinenasyshchennykh zirnykh kislot i priznakov gipertrofii miokarda levogo zheludochka.