Uneventful self poisoning with a very high dose of captopril.
A 43-year-old patient with mild heart failure attempted suicide by ingesting between 5000 and 7500 mg of captopril. Blood pressure oscillated around 100-120/50-75 mmHg and pulse rate showed no tendency to accelerate (75-100/min). The psychiatric examination showed no drug induced psychopathological symptoms. The calculated half-life of captopril was 4.4 h. Seven hours after ingestion of approximately 50 times the maximal therapeutic daily dose of captopril the serum concentration reached 20 micrograms/ml. The calculated amount of absorbed captopril was approximately 5400 mg. Atrial natriuretic factor (ANF) plasma levels were slightly elevated and showed no tendency to increase or to fall.
Lechleitner
P
P
Department of Internal Medicine, University of Innsbruck, Austria.
Dzien
A
A
Haring
C
C
Glossmann
H
H
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning; D006207:Half-Life; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders; D013406:Suicide, Attempted
D009320:Atrial Natriuretic Factor; D002216:Captopril