title: A new antipseudomonal cephalosporin CP6162 and its congeners.
abstract: The synthesis and biological activity of a series of 3-[2-(5-hydroxy-4-pyridon-2-yl)ethenyl]cephalosporin derivatives are described. They showed very potent activity against Gram-negative bacteria, especially Pseudomonas aeruginosa. (6R, 7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2 -(1-carboxy-1-methyl)-ethoxyiminoacetamido]-3-[(Z)-2-(1,5-dihydrox y-4- pyridon-2-yl)ethenyl]ceph-3-em-4-carboxylic acid, CP6162 (8e), was selected for further evaluation as antipseudomonal chemotherapeutic agent.
authors: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors: K
authors: K
authors: Iwamatsu
authors: K
authors: K
authors: Atsumi
authors: K
authors: K
authors: Sakagami
authors: H
authors: H
authors: Ogino
authors: T
authors: T
authors: Yoshida
authors: T
authors: T
authors: Tsuruoka
authors: S
authors: S
authors: Shibahara
authors: S
authors: S
authors: Inouye
authors: S
authors: S
authors: Kondo
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D002511:Cephalosporins; C066804:CP 6162