5-benzylidene pyrrolones. IV--Synthesis and antifungal activity of some 5-benzylidene derivatives of 1,2-dimethyl-3-carbethoxy-pyrrol-4-one.
In order to investigate the antifungal activity of pyrrolones, the synthesis of derivatives of 5-benzylidene-1,2,-dimethyl-3-carbethoxy-pyrrol-4-one was achieved by a one-step reaction. The condensation reaction was applied to the above-mentioned heterocycle and seven substituted benzaldehydes were obtained providing the entitled compounds, of which six are original. They have preferential E configuration. Antifugal data against Neurospora crassa in comparison with ketoconazole showed that many of the compounds exhibit interesting antifungal activity.
Higino
J S
JS
Département d'Antibiotiques, Université Fédérale de Pernambuco, Récife, Brésil.
Lins-Galdino
S
S
Da Rocha-Pitta
I
I
De Lima
J G
JG
Luu-Duc
C
C
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007654:Ketoconazole / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009492:Neurospora crassa / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D001597:Benzylidene Compounds; D011758:Pyrroles; D007654:Ketoconazole