Granulomatous hepatitis in a patient receiving methimazole.
A very rare case of granulomatous hepatitis in a 56-year old woman with hyperthyroidism, under long-term treatment with methimazole, is reported. Liver biopsy showed multiple non caseous granulomas in the portal triads, consisted of epithelioid and multinucleated cells, lymphocytes and isolated eosinophils. The presence of eosinophils in granulomas, could indicate an iatrogenic aethiology.
Di Gregorio
C
C
Istituto di Anatomia e Istologia Patologica, Università di Modena, Ospedale Estense, U.S.L.N. 16, Italy.
Ghini
F
F
Rivasi
F
F
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008713:Methimazole / Q000009:adverse effects*; D008875:Middle Aged
D008713:Methimazole