Neopterin and beta-2 microglobulin levels in asymptomatic HIV infection: the predictive value of combining markers.
The concentrations of neopterin, beta-2 microglobulin, p24 antigen, anti-p24 antibody, and alpha-interferon were determined in the sera of 25 asymptomatic anti-HIV positive patients (CDC stages II and III) over a 50 month period (38 months retrospectively and 12 months prospectively). Evaluation of the data allowed the derivation of a threshold of abnormality for both neopterin and beta-2 microglobulin. Pre-AIDS (CDC groups IVa, IVc2, IVe) developed in 6 of the 26 patients within 18 months of the first abnormal value of beta-2 microglobulin, and within 12 months of the first abnormal value of neopterin. Combining the abnormal results of neopterin, beta-2 microglobulin, p24 antigen, and alpha-interferon allows prediction of progression to pre-AIDS within 18 months for most asymptomatic patients.
Harrison
N A
NA
Department of Communicable and Tropical Diseases, Birmingham Hospital, England.
Skidmore
S J
SJ
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D000914:Antibodies, Viral / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001708:Biopterins / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D015683:Gene Products, gag / Q000276:immunology; D016655:HIV Core Protein p24; D015658:HIV Infections / Q000175:diagnosis*; D006679:HIV Seropositivity / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000276:immunology; D008297:Male; D019798:Neopterin; D011237:Predictive Value of Tests; D011379:Prognosis; D014758:Viral Core Proteins / Q000276:immunology; D001613:beta 2-Microglobulin / Q000032:analysis*
D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral; D015683:Gene Products, gag; D016655:HIV Core Protein p24; D007370:Interferon Type I; D014758:Viral Core Proteins; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin