Metalloproteinases and their inhibitors in matrix remodeling.
The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions. Interestingly, experiments designed to improve our understanding of metalloproteinase regulation have also resulted in new insights into mechanisms by which growth factors and proto-oncogenes may regulate biological processes.
Matrisian
L M
LM
Department of Cell Biology, School of Medicine, Vanderbilt University, Nashville, TN 37232.
D000595:Amino Acid Sequence; D000818:Animals; D004622:Embryo, Mammalian / Q000201:enzymology; D004625:Embryo, Nonmammalian; D005109:Extracellular Matrix / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D012333:RNA, Messenger; D008666:Metalloendopeptidases