MHC class II molecules (Ia-antigens) on macrophages in BB/W rats.
The percentage, absolute number and expression of Ia-antigen of macrophages (Mø) in peripheral blood cells (PBC) and splenocytes from Bio-Breeding/Worcester (BB/W) rats were evaluated. The percentage of Mø in PBC and splenocytes from BB/W rats was significantly higher than those in normal Wistar rats from Clea Japan Inc. (NW/C) and Charles River Japan Inc. (NW/CR). The percentage of Ia-positive Mø in PBC and splenocytes from BB/W rats was significantly increased compared with that in NW/C rats. On the other hand, there was no significant difference in the percentage of Ia-positive Mø of PBC between BB/W and NW/CR rats, and the percentage of Ia-positive Mø in the spleen from BB/W rats was significantly lower than those in NW/CR rats. Thus, the quantity of MHC class II molecules on circulating Mø is not related to the pathogenesis of diabetes mellitus in BB/W rats.
Suzuki
M
M
Fourth Department of Internal Medicine, Saitama Medical School, Japan.
Kawazu
S
S
Negishi
K
K
Shunto
S
S
Moritani
S
S
Inoue
I
I
Takei
S
S
Ishii
J
J
Komeda
K
K
D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007958:Leukocyte Count; D008264:Macrophages / Q000276:immunology*; D051381:Rats; D011913:Rats, Inbred BB / Q000276:immunology*; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology
D000949:Histocompatibility Antigens Class II