[Subcutaneous nodules and sensitivity to aluminum in patients undergoing hyposensitivity immunotherapy].
Hypersensitivity reactions to aluminium are very rate. Sensitization has been reported to occur during continuous application of aluminium-containing antiperspirants or by aluminium adjuvants in vaccines and hyposensitization immunotherapy. We report 5 patients who developed persistent and itching subcutaneous nodules following immunotherapy. Histologically, the nodules showed a granulomatous reaction consistent with delayed hypersensitivity to aluminium. Patch tests with 2% aluminium chloride in water were positive in three patients, and positive results of patch test with other metals (nickel, cobalt) were frequently associated.
García-Patos
V
V
Servicio de Dermatología, Hospital de la Santa Cruz y San Pablo, Barcelona.
Alomar
A
A
Lleonart
R
R
Cistero
A
A
Matias-Guiu
X
X
D000328:Adult; D000536:Aluminum Hydroxide / Q000009:adverse effects*; D001706:Biopsy; D003888:Desensitization, Immunologic; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012882:Skin Tests
D000536:Aluminum Hydroxide
Nódulos subcutáneos y sensibilidad al aluminio en pacientes con inmunoterapia hiposensibilizante.