Antibodies to proinsulin and insulin as predictive markers of type 1 diabetes.
The aim of the present study was to test whether proinsulin autoantibodies (IgG-PAA), insulin autoantibodies (IgG-IAA), and islet cell antibodies (ICA) may be used to identify subjects at risk for Type 1 diabetes. Pre-diabetic sera from 18 individuals who later developed diabetes were tested. Results were compared with 18 age-, sex-, and HLA-DR-matched non-diabetic control subjects from families with Type 1 diabetes. At a mean of 2.4 yr before the onset of diabetes, ICA were found in 13 patients (vs 0 control subjects, p less than 0.001), ELISA-determined IgG-IAA in 8 patients (vs 1 control subject, p less than 0.05) and ELISA-determined IgG-PAA in 4 patients (vs 2 control subjects, NS). ELISA-determined IgG-PAA do not appear to be useful predictors of the future development of Type 1 diabetes.
Kuglin
B
B
Diabetes Research Institute, University of Düsseldorf, FRG.
Rjasanowski
I
I
Bertrams
J
J
Gries
F A
FA
Kolb
H
H
Michaelis
D
D
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007330:Insulin Antibodies / Q000032:analysis*; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D011236:Prediabetic State / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D011384:Proinsulin / Q000276:immunology*; D011446:Prospective Studies
D000906:Antibodies; D001323:Autoantibodies; D015415:Biomarkers; D006684:HLA-DR Antigens; D007074:Immunoglobulin G; D007330:Insulin Antibodies; C024211:islet cell antibody; D011384:Proinsulin