[Transcutaneous transport of trinitrin in children after application of nitroglycerin patches].
Plasma levels of nitroglycerin were measured 13 to 24 hours after the application of nitroglycerin stamps in 7 children aged from 1 month to 7 years and suffering from heart failure. The plasma levels varied considerably from one patient to another, confirming that the bioavailability of transdermal nitroglycerin is extremely variable in children. Only 3 patients had a nitraemia higher than 1 ng/ml, a figure compatible with a haemodynamic effect of the drug. No side-effect associated with the nitroglycerin stamps was observed. The dosage we use (a quarter of a stamp for 5 kg bodyweight) seems to be adequate at the beginning of treatment, to be progressively increased according to the way the drug is tolerated.
Vaksmann
G
G
Service de Cardiologie Infantile, Hôpital Cardiologique, Lille.
Rey
E
E
Francart
C
C
Olive
G
G
Dupuis
C
C
D000279:Administration, Cutaneous; D002648:Child; D002675:Child, Preschool; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D013058:Mass Spectrometry; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
D005996:Nitroglycerin
Passage transcutané de la trinitrine chez l'enfant après application de timbres de nitroglycérine.