A new, low-incidence red cell antigen (HOFM), associated with depressed C antigen.
A case of mild hemolytic disease of the newborn is presented which was caused by an antibody to a hitherto unknown antigen of low incidence. This antigen, now designated as HOFM (ISBT number 700050) was detected in 6 relatives, and in all of them, it was associated with an unusually weakened expression of C antigen. The serological data indicate that HOFM may be part of the Rh system, but the genetic data, although supportive of this interpretation, are inconclusive.
Hoffmann
J J
JJ
Department of Clinical Laboratories, Catharina Hospital, Eindhoven, The Netherlands.
Overbeeke
M A
MA
Kaita
H
H
Loomans
A A
AA
D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D004899:Erythroblastosis, Fetal / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D010375:Pedigree; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D007519:Isoantigens; D012204:Rh-Hr Blood-Group System