Dual genotype in cutaneous T-cell lymphomas and pseudolymphomas.
Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patients contained a monoclonal T-cell population. In addition, DNA from 5 patients contained an immunoglobulin gene rearrangement. These results demonstrate that cutaneous T-cell lymphomas are clonal T-cell malignancies that frequently express a dual genotype, which may sometimes reflect the clonotypic heterogeneity of these disorders.
Bignon
Y J
YJ
Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, Clermont-Ferrand, France.
Souteyrand
P
P
Roger
H
H
Bernard
D
D
Dastugue
B
B
Ramos
F
F
d'Incan
M
M
Chollet
P
P
Plagne
R
R
D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005838:Genotype; D006801:Humans; D007133:Immunoglobulin Joining Region / Q000235:genetics; D008223:Lymphoma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D013601:T-Lymphocytes
D007133:Immunoglobulin Joining Region