Post-necrotising enterocolitis pseudo-obstruction treated with Cisapride.
We report on one patient in whom segmental colic intestinal pseudo-obstruction (IPO) following the surgical treatment of a grade III necrotising enterocolitis (NEC) was responsible for a severe failure to thrive. Further intestinal resection in an already short gut was avoided by using Cisapride, a new intestinal prokinetic agent (1 mg/kg/d in 4 doses, orally), which dramatically improved the symptoms and allowed weight gain and intestinal adaptation. After 6 months, Cisapride was withdrawn. IPO did not recur after 2 years of follow-up, although proximal distention persisted.
Vanderwinden
J M
JM
Département de Chirurgie Pédiatrique, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Belgium.
Dassonville
M
M
Van der Veken
E
E
Cadranel
S
S
De Laet
M H
MH
D020117:Cisapride; D003112:Colonic Pseudo-Obstruction / Q000188:drug therapy*; D004750:Enteral Nutrition; D004761:Enterocolitis, Pseudomembranous / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000601:surgery*; D008297:Male; D010880:Piperidines / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*; D012702:Serotonin Antagonists
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride