[Anti-epidermal cytotoxic reactions in the effector stage of lichen ruber planus].
Immunohistochemical investigations on skin lesions of lichen ruber planus indicate HLA-DR-expression by keratinocytes, Langerhans cells (LC), and infiltrated mononuclear cells. In the early stage of this condition, the lymphocytic infiltrate consists of a considerable part of (CD8+) cytotoxic/suppressor- and (LGL+) natural killer cells. Evidently, the cytotoxic potential of these lymphocyte subpopulations is directed against basal keratinocytes and epidermal LC. As a result of cytotoxic/cytolytic activities, non-cell associated CD 1-reactivity accumulates in the dermoepidermal junction zone, thus indicating damaged LC.
Laub
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Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Martin-Luther-Universität Halle-Wittenberg.
Narwutsch
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D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008010:Lichen Planus / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens
Antiepidermale zytotoxische Reaktionen in der Effektorphase des Lichen ruber planus.