title: S100 protein and Down syndrome.
abstract: S100 protein is a low molecular weight calcium-binding protein widely distributed in the central nervous system of vertebrates. Recent evidence suggests that S100 protein may play a role in the regulation of glial proliferation and neuronal differentiation. The gene for S100 protein has been mapped to the 21q22 region, a chromosomal locus whose duplication has been implicated in the generation of Down Syndrome (DS). This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS.
authors: Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.
authors: A
authors: A
authors: Marks
authors: R
authors: R
authors: Allore
mesh_terms: D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D003001:Cloning, Molecular; D004314:Down Syndrome / Q000235:genetics*; D005796:Genes; D006801:Humans; D009418:S100 Proteins / Q000032:analysis / Q000235:genetics*
chemical_list: D009418:S100 Proteins