Translational control mediated by UA-rich sequences.
Several messenger RNAs coding for cytokines, growth factors or oncoproteins contain a conserved UA-rich sequence in their 3' untranslated regions. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, is a key element in the posttranscriptional regulation of these mRNAs. Previously shown to be involved in mRNA destabilization, these UA-rich elements can also strongly influence mRNA translation. A translation inhibition mediated by these sequences has indeed been observed in vitro as well as in frog oocyte or in somatic cells.
Kruys
V
V
Howard Hughes Medical Center, University of Texas Southwestern Medical Center, Dallas.
Beutler
B
B
Huez
G
G
D000818:Animals; D004252:DNA Mutational Analysis; D005786:Gene Expression Regulation; D066298:In Vitro Techniques; D016899:Interferon-beta / Q000235:genetics; D009865:Oocytes / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D011993:Recombinant Fusion Proteins; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014981:Xenopus / Q000235:genetics
D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; D016899:Interferon-beta