title: Comparative study of monocomponent insulins and conventional insulins on the course of diabetic nephropathy. A follow-up study.
abstract: Two matched groups of insulin requiring non-insulin dependent diabetic (NIDDM) patients with mild proteinuria (200 to 999 mg/day), one on mono component (MC) insulin therapy and the other on conventional insulins were studied for a 3 year period to evaluate the course of nephropathy in these two groups. Twenty-seven and 35 patients were followed-up in the MC insulin and conventional insulin groups respectively. In the MC insulin treated group, the percentage of patients showing deterioration in proteinuria was lower (11% vs 34%, P less than 0.05) and the percentage showing improvement was higher (48% vs 29%) compared to the conventional insulin treated group. Insulin antibody titres decreased significantly in the MC insulin group and serum C-peptide values decreased in both groups on follow-up.
authors: Department of Biochemistry, Diabetes Research Centre, Madras.
authors: M
authors: M
authors: Viswanathan
authors: C
authors: C
authors: Snehalatha
authors: V
authors: V
authors: Mohan
authors: A
authors: A
authors: Ramachandran
authors: R
authors: R
authors: Mohan
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000517:prevention & control*; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*
chemical_list: D007328:Insulin