Hormonal control of cardiac lipolysis by glyco(geno)lysis.
The importance of the glucose/fatty acid cycle in the control of cardiac lipolysis is emphasized by the following observations. Addition of the glycogen debranching inhibitor deoxynojirimycin or an O2-vehicle, fluorocarbon F-43, to media perfusing paced, lipid-enriched, Langendorff hearts lower cardiac lactate and glycerol 3-phosphate levels together with inhibition of glucagon-stimulated glycerol (and lactate) release. The absence of fluorocarbon during perfusion of 5 Hz paced langendorff hearts probably results in limited tissue oxygenation, resulting in glycogenolysis and lipolysis. The results indicate hormonal control of cardiac lipolysis by glyco(geno)lysis.
Hülsmann
W C
WC
Department of Thorax Center, Medical Faculty, Erasmus University Rotterdam, The Netherlands.
De Wit
L E
LE
Stam
H
H
Schoonderwoerd
K
K
D017485:1-Deoxynojirimycin; D000818:Animals; D005934:Glucagon / Q000494:pharmacology; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D000860:Hypoxia; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D008066:Lipolysis / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D007773:Lactates; D017485:1-Deoxynojirimycin; D006003:Glycogen; D005934:Glucagon; D005944:Glucosamine; D005990:Glycerol