Plasma alpha-atrial natriuretic peptide concentrations in acute respiratory failure associated with sepsis: preliminary study.
Plasma alpha-atrial natriuretic peptide (alpha-ANP) concentrations were measured during mechanical ventilation in nine patients with acute respiratory failure (ARF) associated with sepsis. The relationships between alpha-ANP and pulmonary hemodynamic variables were examined. A total of 22 measurements of alpha-ANP and other variables were obtained. The mean plasma alpha-ANP concentration of 22 measurements was 120.1 +/- 79.8 pg/ml (normal 31.7 +/- 12.0, mean +/- SD). Plasma alpha-ANP concentrations correlated with mean pulmonary artery pressure (MPAP) (r = .703, p less than .01) and pulmonary vascular resistance (PVR) (r = .606, p less than .01), but not with other variables. These findings suggest that alpha-ANP elevation may be related to the increases in MPAP and PVR in ARF associated with sepsis.
Mitaka
C
C
Section of Intensive Care, Tokyo Medical and Dental University, Japan.
Nagura
T
T
Sakanishi
N
N
Tsunoda
Y
Y
Toyooka
H
H
D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D006801:Humans; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D018805:Sepsis / Q000503:physiopathology*; D014655:Vascular Resistance
D009320:Atrial Natriuretic Factor