Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin.
We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared unexpectedly and, by contrast, it disappeared in some H6+/H6+ homozygote offspring. Based on pedigree analysis, a transregulation of H6 expression in the serum by an autosomal recessive gene not linked to the structural allotype gene is postulated.
Fomicheva
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Institute of Cytology and Genetics, USSR Academy of Sciences, Siberian Branch, Novosibirsk.
Volkova OYu
D000818:Animals; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D005808:Genes, Recessive; D005809:Genes, Regulator; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics; D008907:Mink / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains