Toxic effects of acute exposure to particular xylene isomers in animals.
The effect of exposure to particular xylene isomers at a concentration of 3000 ppm on rotarod performance in rats and the respiratory rate in mice was investigated. Rotarod performance was tested in rats immediately after termination of a 6-hour exposure, and the respiratory rate in mice was recorded during a short 6 minute exposure to individual xylene isomers. In both rats and mice the toxic effects of exposure to ortho- and meta-xylene were more pronounced than that of para-xylene.
Korsak
Z
Z
Department of Toxicity Evaluation, Nofer Institute of Occupational Medicine, Lodz, Poland.
Sokal
J A
JA
Wasiela
T
T
Swiercz
R
R
D000208:Acute Disease; D000818:Animals; D007536:Isomerism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009469:Neuromuscular Junction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D014992:Xylenes / Q000633:toxicity*
D014992:Xylenes