title: Evaluation of activity in postoperative acromegalics--plasma growth hormone levels during oral glucose tolerance test, daytime blood sampling and urinary GH excretion.
abstract: Plasma growth hormone (GH) levels during oral glucose tolerance test (OGTT) and during the daytime (0900-1700 h) and urinary GH excretion were determined in 6 normal subjects and 10 patients with postoperative acromegaly by means of a highly sensitive enzyme immunoassay (EIA). Acromegalic patients were divided into two groups according to their GH responses during OGTT. In group I patients plasma GH was suppressed below 1.0 microgram/l as in normal subjects, whereas GH levels persisted above 1.0 microgram/l in group II patients. Plasma GH profiles during the daytime were characterized by low nadir GH levels in normal subjects (0.21 +/- 0.10 microgram/l and group I patients (0.38 +/- 0.10 microgram/l) when compared with those in group II patients (4.7 +/- 2.0 microgram/l). Nadir GH levels during the daytime coincided with those during OGTT. Urinary GH excretions in group I patients (median 12 ng/day, range 4.3-29 ng/day) were within normal limits (2.6-20 ng/day) and significantly lower than those in group II patients (median 40 ng/day, range 19-130 ng/day.) Determination of plasma GH levels during OGTT and urinary GH excretion by the highly sensitive enzyme immunoassay is useful in evaluating the activity of postoperative acromegaly.
authors: Department of Endocrinology, Kobe General Hospital, Japan.
authors: N
authors: N
authors: Hattori
authors: A
authors: A
authors: Shimatsu
authors: T
authors: T
authors: Tanoh
authors: H
authors: H
authors: Koshiyama
authors: Y
authors: Y
authors: Kato
authors: H
authors: H
authors: Imura
mesh_terms: D000172:Acromegaly / Q000378:metabolism* / Q000601:surgery; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013973:Thyrotropin-Releasing Hormone / Q000097:blood
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D005947:Glucose