Andrological investigations in men treated with acitretin (Ro 10-1670).
Ten subjects were treated orally with acitretin (Ro 10-1670) over a period of 3 months. Before, during and after treatment, semen and blood analyses were performed to investigate drug-induced impairment of spermatogenesis and the hypothalamic-pituitary-gonadal axis. Our study concludes that acitretin in therapeutically effective doses does not influence spermatogenesis, sperm morphology, sperm motility and the hypothalamic-pituitary-gonadal axis.
Parsch
E M
EM
Dermatologische Klinik und Poliklinik d. Ludwig-Maximilian-Universität München/FRG.
Ruzicka
T
T
Przybilla
B
B
Schill
W B
WB
D017255:Acitretin; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D012098:Reproduction / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D014212:Tretinoin / Q000009:adverse effects / Q000031:analogs & derivatives*
D013739:Testosterone; D014212:Tretinoin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017255:Acitretin