[The effect of carbacyclin on the ATPase activity in the heart of normotensive and spontaneously hypertensive rats with a hereditary susceptibility to stroke].
Effects of carbacyclin, a synthetic analogue of prostacyclin on Na, K-ATPase, Ca, Mg- and Ca-ATPase activity of plasmatic membrane (PM) and sarcoplasmic reticulum (SR) of the heart normotensive (WKY) and stroke-prone spontaneously hypertensive (SHR-SP) rats were examined. In SR carbacyclin was found to increase Ca, Mg- and Ca-ATPase activity in SHR-SP and decrease the activity of this enzymes in WKY. Carbacyclin caused identical effect on ATPase activity in PM in WKY and SHR-SP, but the greatest effects were in WKY.
Vasil'eva
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000201:enzymology; D004198:Disease Susceptibility / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000627:therapeutic use* / Q000031:analogs & derivatives; D006321:Heart / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D011465:Prostaglandins, Synthetic; C026678:carboprostacyclin; D011464:Epoprostenol; D000251:Adenosine Triphosphatases
Vliianie karbotsiklina na ATFaznuiu aktivnost' v serdtse normotenzivnykh i spontanno-gipertenzivnykh krys s nasledstvennoĭ predraspolozhennost'iu k insul'tam.