[T-cell subsets, lymphocyte proliferation and IL-2 level in patients with anterior uveitis].
The authors used the OKT monoclonal anti-T-lymphocyte antibodies to enumerate the T-cell subsets in the peripheral blood of 47 patients with anterior uveitis (AU) by indirect immunofluorescence assay. The T-cell proliferative response to PHA and IL-2 production of the patients were also studied. The results were that the patients with AU had higher percentage of OKT4 + cells, and the T4 +/T8 + ratio increased. The percentage of OKT4 + cells in patients with active AU was lower than in patients with inactive AU. The proliferative response to PHA and PHA-induced IL-2 production in patients with active AU decreased, while they were normal in patients with inactive AU.
Wei
S A
SA
Department of Immunology, Beijing Medical University.
D000911:Antibodies, Monoclonal / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008213:Lymphocyte Activation; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014606:Uveitis, Anterior / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D007376:Interleukin-2