Bilateral deep venous thrombosis in protein S deficiency. Detection by radionuclide venography.
Patients with primary hypercoagulopathies often present with recurrent, spontaneous deep venous thrombosis and pulmonary embolism. An adolescent eventually diagnosed with protein S deficiency presented with unilateral deep venous thrombosis documented ultrasonographically. Scintigraphic studies showed no evidence of pulmonary embolism but revealed a complete absence of deep venous flow in both lower extremities, the pelvis, and the abdomen. Subsequent ultrasonography and CT scanning documented this marked thrombotic extension. Radionuclide scintigraphy may play an important role in the serial evaluation of primary hypercoagulable states, particularly when pulmonary scintigraphy is combined with bilateral, lower extremity venography.
Wegener
W A
WA
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Heyman
S
S
D000293:Adolescent; D001796:Blood Protein Disorders / Q000150:complications*; D001798:Blood Proteins / Q000172:deficiency*; D005268:Femoral Vein; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D008297:Male; D017293:Protein S; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology; D014682:Vena Cava, Inferior
D001798:Blood Proteins; D006023:Glycoproteins; D017293:Protein S; D013668:Technetium Tc 99m Aggregated Albumin