Inhibition of neutrophil-mediated lysis of syngeneic erythrocytes by components of blood serum and peritoneal fluid.
Experiments are reported in which it is shown that murine blood serum and peritoneal fluid contain compounds of high molecular mass that inhibit the lysis of murine erythrocytes caused by syngeneic neutrophils, and that these inhibitors directly affect the neutrophils. Neutrophil sensitivity to phorbol 12-myristate 13-acetate (PMA) changes in the presence of these high-molecular-mass serum components, whereas their sensitivity to opsonized zymosan does not.
Smirnov
S V
SV
Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR, Moscow Region.
Sukharev
S A
SA
Dmitrieva
E S
ES
Morgunova
L V
LV
Sadovnikov
V B
VB
D000818:Animals; D001202:Ascitic Fluid / Q000503:physiopathology; D001790:Blood Physiological Phenomena; D006461:Hemolysis / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D015054:Zymosan; D013482:Superoxide Dismutase; D013755:Tetradecanoylphorbol Acetate