[The effect of anti-insulin antibodies and of peptide C residual secretion on the metabolic control of diabetes type 1].
In 20 type I diabetic patients treated with conventional insulin preparations, we measured insulin antibodies and peptide C secretion. Peptide C levels 90 and 120 min after a standard breakfast correlated well with glucosylated Hb levels (r = -0.48 and -0.52, respectively). No correlation with free insulin levels was observed, in spite of a good correlation of the latter with blood glucose levels (r = -0.50 and -0.73, respectively). There was no relation between insulin antibody levels and peptide C or free insulin. Metabolic control was not affected by insulin antibodies. Insulin dose decreased in relation to the duration of the disease and reduction of body weight index and was not correlated to glycosylated Hb levels.
Velasco
N
N
Departamento Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, Universidad Católica de Chile, Santiago.
Díaz de Valdés
M
M
Arteaga
A
A
Acosta
A M
AM
Pellegrini
M R
MR
Foradori
A
A
D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000097:blood* / Q000187:drug effects; D008297:Male; D010455:Peptides / Q000097:blood / Q000187:drug effects / Q000378:metabolism*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D007330:Insulin Antibodies; D010455:Peptides; C050632:polypeptide C
Influencia de anticuerpos antiinsulina y de la secreción remanente de péptido C en el control metabólico de diabetes tipo I.