Hormonal regulation of haemostasis and the molecular biology of the fibrinolytic system.
The major components of the fibrinolytic system are responsive to hormones, growth factors and cytokines in a wide variety of primary and neoplastic cell lines. These effectors commonly cause increased biosynthesis of PAI-1 with overall suppression of fibrinolysis. Recent studies have indicated that certain agonists, in particular the inflammatory cytokines, may suppress fibrinolysis in animal models. These findings provide a correlate to the clinical observations which relate an increase in PAI-1 levels with thrombotic risk. On the other hand, induction of t-PA and u-PA biosynthesis by growth factors has been related to tissue remodelling and cell migration associated with angiogenesis and tumour metastasis.
Grant
P J
PJ
University Department of Medicine, General Infirmary, Leeds, U.K.
Medcalf
R L
RL
D001777:Blood Coagulation / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006728:Hormones / Q000502:physiology*; D006801:Humans
D006728:Hormones