[Calcium transport in endoplasmic reticulum of the rat liver during lipid peroxidation].
Some parameters of calcium transport in rat liver microsomes under conditions of lipoperoxidation activation modelled by antioxidant deficiency (AOD) were studied. This process was shown to be associated with a sharp stimulation of NADPH- and ascorbate-dependent lipid peroxidation in hepatocyte endoplasmic reticulum. The activation of lipid peroxidation was accompanied by disturbances in the kinetic properties of Ca2(+)-ATPase. This was paralleled with a considerable decrease of the ATP-dependent 45Ca-accumulation, increase in the passive permeability of microsomal vesicles for Ca2+ and Ca2+ elevation in the microsomal fraction. The AOD-induced diminution of the Ca2(+)-pump efficiency was slightly prevented by injections of rats with the antioxidants, alpha-tocopherol acetate and ionol which enable Ca2+ compartmentation correction in liver cytosol and membrane fractions.
Gubskiĭ
Iu I
IuI
Kurskiĭ
M D
MD
Zadorina
O V
OV
Fedorov
A N
AN
Briuzgina
T S
TS
Iurzhenko
N N
NN
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D000252:Calcium-Transporting ATPases; D002118:Calcium
Transport kal'tsiia v éndoplazmaticheskom retikulume pecheni krys pri aktivatsii perekisnogo okisleniia lipidov.