Effect of atrial natriuretic peptide on renin release in rat isolated glomeruli.
Effects of atrial natriuretic peptide (ANP) on renin release in isolated rat glomeruli were investigated. ANP suppressed renin release by 25% at 5 x 10(-8) M when glomeruli were incubated in a medium containing 1.26 mM calcium (p = 0.0019). When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively). These results indicate that ANP suppresses renin release in a dose dependent manner, probably through a calcium independent process.
Kageyama
S
S
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Brown
J
J
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
D004533:Egtazic Acid; D009320:Atrial Natriuretic Factor; D012083:Renin; D002118:Calcium