Cellular retinol binding protein and breast carcinoma.
Cellular retinol binding protein (C-RBP) levels were measured in 87 malignant and 18 non-malignant breast cancer tissues. C-RBP, sedimenting in the '2S' region on 5-20% sucrose density gradients, was detectable in 70% of malignant tissues examined. None of the non-malignant tissues contained detectable C-RBP. No significant association between tumour steroid receptors status, patients' obesity or menopausal status and C-RBP contents was observed. However, patients with stage IV disease had higher C-RBP levels than patients at stages II and III (P less than 0.0001), which suggested altered intracellular mobilization of retinol in the tumour, probably as an indirect consequence of inadequate nutrient intake.
Mehta
R R
RR
Department of Surgery, University of Illinois, Chicago 60612.
Hart
G D
GD
D001943:Breast Neoplasms / Q000737:chemistry*; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular