[Mutagenic activity of antineoplastic agents under conditions of normal and artificial modification].
Mutagenic effect of vincristine, vinblastine, thiophosphamide, sarcolysine and the supermutagen ethyleneimine was studied in Crepis capillaris germinating seeds at the G phase. Metabolic conditions, prolongation of cell cycle, specific activity of preparation as well as inhibition of DNA synthesis were found to modify the mutagenic process induced by antitumour agents.
Semenov
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D000970:Antineoplastic Agents / Q000633:toxicity*; D001388:Aziridines / Q000633:toxicity; D002869:Chromosome Aberrations / Q000235:genetics; D007399:Interphase / Q000187:drug effects; D008558:Melphalan / Q000633:toxicity; D009153:Mutagens; D010944:Plants / Q000187:drug effects / Q000235:genetics*; D013852:Thiotepa / Q000633:toxicity; D014747:Vinblastine / Q000633:toxicity; D014750:Vincristine / Q000633:toxicity
D000970:Antineoplastic Agents; D001388:Aziridines; D009153:Mutagens; C033132:aziridine; D014750:Vincristine; D014747:Vinblastine; D013852:Thiotepa; D008558:Melphalan
Mutagennaia aktivnost' protivoopukholevykh preparatov v usloviiakh estestvennoĭ u iskusstvennoĭ modifikatsii.