title: Role of atrial natriuretic factor in renal adaptation to variation of salt intake in humans.
abstract: This study was performed to define the extent to which atrial natriuretic factor (ANF) contributes to upregulate salt excretion in subjects eating a high-salt diet. Eight normal volunteers were first studied at low-salt diet (80 mmol NaCl/day); urinary sodium excretion (UNaV) and plasma ANF (PANF) were measured in the basal condition and during stepwise infusion of human alpha-ANF at 2, 4, 8, and 16 ng.min-1.kg-1. Then the same subjects were shifted to a high-salt diet (400 mmol/day), and UNaV and PANF were measured in the new balance condition. At low-salt diet, UNaV averaged 0.069 meq/min, and PANF averaged 21 pg/ml; infusion of human alpha-ANF raised stepwise both UNaV and PANF (means in meq/min and pg/ml, respectively, were 0.177 and 46, 0.218 and 76, 0.360 and 86, and 0.601 and 182). Infusion of ANF caused a progressive fall of plasma aldosterone and plasma renin activity. Mean UNaV and PANF at high-salt diet were 0.301 meq/min and 35 pg/ml. Thus, by increasing experimentally PANF in a low-salt diet condition to the levels occurring physiologically in a high-salt diet condition, a significant rise in UNaV is evoked, which accounts for approximately 50% of the rise of UNaV that is necessary to balance the increased salt intake.
authors: Department of Nephrology, University of Catanzaro, Italy.
authors: A
authors: A
authors: Dal Canton
authors: G
authors: G
authors: Romano
authors: G
authors: G
authors: Conte
authors: L
authors: L
authors: De Nicola
authors: A
authors: A
authors: Caglioti
authors: P
authors: P
authors: Veniero
authors: F
authors: F
authors: Uccello
authors: V E
authors: VE
authors: Andreucci
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000502:physiology*; D008297:Male; D009318:Natriuresis; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D003404:Creatinine; D012083:Renin