[3H]paroxetine binding in human platelets in relation to age and sex.
The binding of [3H]paroxetine to serotonin uptake sites in human platelets from 47 individuals between 15 and 95 years of age was investigated. There were no significant age-related changes in maximal binding capacity (Bmax) or apparent binding affinity (Kd). There were no significant differences in binding between males (n = 19) and females (n = 28).
Andersson
A
A
Department of Geriatric Medicine, University of Umeå, Sweden.
Marcusson
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D001667:Binding, Competitive / Q000187:drug effects; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D017374:Paroxetine; D010880:Piperidines / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000097:blood*; D012737:Sex Factors
D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017374:Paroxetine; D007099:Imipramine