Ontogenic development of immunoregulation in rats.
Suppressor activity of newborn rat spleen cells is totally inhibited on day 3 after birth by immunoregulatory cells of thymic origin. Contrasuppression represents a necessary, evolutionary step in the ontogenic development of the immune system.
Bubak-Satora
M
M
Department of Immunobiology, Polish Academy of Sciences, Krakow, Poland.
Skowron-Cendrzak
A
A
D000367:Age Factors; D000818:Animals; D005260:Female; D007108:Immune Tolerance; D007109:Immunity; D008297:Male; D051379:Mice; D051381:Rats; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology