title: A meta-analysis of stages I and II Hodgkin's disease.
abstract: To compare radiotherapy alone to chemotherapy plus radiotherapy in the treatment of early stage Hodgkin's disease, the English language medical literature was searched for reports on randomized clinical trials in Stages I and II Hodgkin's disease from 1975 through 1986. Twenty-three reports with 2999 patients were entered into matched study analysis. Data on extended-field radiotherapy (EF), involved-field (IF), chemotherapy alone, combination chemotherapy and radiotherapy (CM), disease stage, laparotomy staging, and complications were gathered. A proportional hazard rate was used to estimate and compare relapse-free (RFS) and overall survival rates (S). Iteratively reweighted least square analysis was used to estimate survival curves. Twelve-year RFS for CM (889 patients) was significantly superior to EF (1350 patients) (P less than 0.01). Twenty-year RFS in EF was better than IF (760 patients) (P less than 0.01). Twelve-year S for CM was not significantly different than for EF but was better than for IF (P less than 0.05).
authors: Manitoba Cancer Treatment, Vinnipeg, Canada.
authors: T
authors: T
authors: Shore
authors: N
authors: N
authors: Nelson
authors: B
authors: B
authors: Weinerman
mesh_terms: D003131:Combined Modality Therapy / Q000009:adverse effects; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007813:Laparotomy; D015201:Meta-Analysis as Topic; D009367:Neoplasm Staging; D015996:Survival Rate