Cyanide intoxication--III. On the analogous and different effects provoked by non-lethal and lethal challenged doses.
1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-L-methionine (SAM) and thiosulphate were investigated. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and delta-aminolevulinic acid dehydratase (ALA-D) activity. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered.
Buzaleh
A M
AM
Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP)-CONICET-Facultad de Ciencias, Exactas y Naturales, University of Buenos Aires, Argentina.
Vazquez
E S
ES
del Carmen Batlle
A M
AM
D000818:Animals; D003486:Cyanides / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D007928:Lethal Dose 50; D051379:Mice; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000494:pharmacology; D013462:Sulfur Radioisotopes; D013861:Thiocyanates / Q000097:blood / Q000652:urine; D013884:Thiosulfate Sulfurtransferase / Q000037:antagonists & inhibitors; D013885:Thiosulfates / Q000097:blood / Q000494:pharmacology
D003486:Cyanides; D011506:Proteins; D013462:Sulfur Radioisotopes; D013861:Thiocyanates; D013885:Thiosulfates; D012436:S-Adenosylmethionine; D003576:Electron Transport Complex IV; D013884:Thiosulfate Sulfurtransferase; D000623:Porphobilinogen Synthase