Effect of mannitol, n-2-mercaptopropionyl glycine and sodium nitroprusside on EEG recovery following cerebral ischemia and reperfusion in the rat.
The efficacy of free radical scavengers (mannitol and n-2-mercaptopropionyl glycine) and a vasodilator (sodium nitroprusside) on the EEG recovery following cerebral ischemia was studied in the anesthetized rat. Global ischemia of brain was produced by the four-vessel occlusion for 30 min followed by 3 h reperfusion. Blood pressure, heart rate and EEG were monitored. The test agents were infused intravenously 15 min before and immediately after cerebral ischemia. The results indicate that mannitol 20-50 mg/kg, n-2-mercaptopropionyl glycine 10-20 mg/kg and sodium nitroprusside 20-50 micrograms/kg singly or in combination improved EEG recovery during reperfusion.
Huang
T F
TF
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Huang
L L
LL
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D004569:Electroencephalography; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D008625:Tiopronin / Q000494:pharmacology*
D009599:Nitroprusside; D008353:Mannitol; D008625:Tiopronin