[Male genito-urinary tract infection caused by Chlamydia trachomatis and seminal characteristics: use of minocycline].
The authors evaluated the activity of Minocycline in 30 male patients with urinary tract infection caused by Chlamydia trachomatis (Ct) and alterations of the seminal parameters using three different dosage schedules (100 mg/day for 10 days, 200 mg/day for 10 days and 200 mg/day for 20 days). At baseline, at the end of therapy and one month after clinical and bacteriological parameters and seminal characteristics, including some sperm function tests (acridine orange test to study chromatin heterogeneity; triple staining technique, to study acrosome; swim-up technique, to study the sperm kinetics) were verified. The seminal characteristics were checked again three and six months after the end of the therapy. All the results show that Minocycline is an excellent drug for the treatment of urinary tract infection caused by Chlamydia trachomatis both for its therapeutic efficacy and for the absence of side effects. Although 10 days cycles using 1 cap/day are sufficient to eliminate inflammation and infection, in order to obtain more valid results it is preferable to use the following dosage schedule: 200 mg/day of antibiotic (100 mg twice daily) for 10 days. The results of our trial show that in cases of Chlamydia trachomatis infection associated with dispermia (reduced nemaspermic concentration, hypomotility, teratozoospermia, increased number of leucocytes), if the parameters of sperm function are within normal limits, the resolution of the infection is usually followed by a recovery of normozoospermia. Follow-up performed 3 and 6 months after the end of treatment showed an increase in the number of spermatozoa, a percentage increase in their motility, mostly in the progressive motility, and a reduction of the atypical forms.(ABSTRACT TRUNCATED AT 250 WORDS)
Lombardo
F
F
Laboratorio di Immunologia della Riproduzione e Seminologia, Università di Roma, La Sapienza.
Gandini
L
L
Alfano
P
P
Anticoli-Borza
L
L
Basile
A
A
Fabbri
G
G
Lenzi
A
A
D000328:Adult; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D013076:Sperm Count; D013081:Sperm Motility; D013754:Tetracyclines / Q000627:therapeutic use*; D014522:Urethral Diseases / Q000150:complications / Q000188:drug therapy*
D013754:Tetracyclines; D008911:Minocycline
Infezione del tratto genito-urinario maschile da Chlamydia trachomatis e caratteristiche seminali: impiego della minociclina.