[Adaptive rearrangements in the myocardium, lung and liver of mice in altitude conditions after administration of immunomodulators].
In 120 non-inbred white rats, elevated to the height (4,000 m) after a preliminary administration of various combinations of T-activin and cyclophosphamide, structures of the myocardium, lungs and liver have been studied microscopically and morphometrically. Changes in the initial state of the immune system, independently of its character, at first stages of adaptation to conditions of altitude, essentially effect the organs responsible for specific mechanisms of adaptation. When the animals are elevated to the altitude after administration of cyclophosphamide, damaging predominantly the humoral immunity, formation of structural adaptive rearrangements is decelerated up to the 4th week. This practically means failure of adaptation. Preliminary administration of T-activin considerably smooths results of cyclophosphamide, preserving general dynamics in formation of adaptive shifts on the 25th-30th days of adaptation to the altitude.
Belkin
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D000064:Acclimatization / Q000502:physiology*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000531:Altitude; D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D010455:Peptides / Q000008:administration & dosage*; D013620:Tajikistan; D013949:Thymus Extracts / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D003520:Cyclophosphamide
Adaptatsionnye perestroĭki v miokarde, legkikh i pecheni u mysheĭ v usloviiakh vysokogoria na fone deĭstviia immunomoduliatorov.