Tolytoxin and new scytophycins from three species of Scytonema.
Tolytoxin [1], the major cytotoxin associated with Scytonema mirabile strain BY-8-1, Scytonema burmanicum strain DO-4-1 and Scytonema ocellatum strains DD-8-1, FF-65-1, and FF-66-3, has been shown to be 6-hydroxy-7-O-methylscytophycin B. Minor amounts of three other new cytotoxic scytophycins, 6-hydroxyscytophycin B [2], 19-O-demethylscytophycin C [3], and 6-hydroxy-7-O-methylscytophycin E [4], have also been isolated from these cyanophytes. The gross structures and stereochemistry are based on nmr and cd analysis and on comparison with scytophycins A-E.
Carmeli
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Department of Chemistry, University of Hawaii, Honolulu 96822.
Moore
R E
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Patterson
G M
GM
D000935:Antifungal Agents / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D000458:Cyanobacteria / Q000032:analysis*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C068528:6-hydroxy-7-O-methylscytophycin E; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011714:Pyrans; C068527:tolytoxin; C068531:6-hydroxyscytophycin B; C068530:19-O-demethylscytophycin C