Alzheimer's disease amyloid precursor protein is present in the myelin sheath of central nervous system in rat.
By using polyclonal antibodies to C- and N-terminal portions of beta-amyloid precursor protein (APP), we immunohistochemically examined postnatal and adult rat brains. Immunoreactivity was observed in myelin of nerve fibers in myelination and of mature myelinated fibers, as well as in various brain cells. In trigeminal nerve roots, the immunoreactivity was observed in central myelin but not in peripheral myelin. The results strongly suggest that APP is a component of central myelin in rat.
Ikeda
K
K
Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
Tomonaga
M
M
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000032:analysis*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D001923:Brain Chemistry; D007124:Immunoenzyme Techniques; D009186:Myelin Sheath / Q000737:chemistry*; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D011498:Protein Precursors