[Immunogenetics of primary membranous glomerulonephritis].
In 65 patients with a biopsy-proven diagnosis of membranous glomerulonephritis, the association with HLA class I, class II and class III antigens was studied using classical techniques. We found a highly significant association with the HLA-DR3 (Pc = 8 x 10(-5)) antigen and with the HLA-B8 (Pc = 2 x 10(-4)) antigen in linkage disequilibrium with the former. In addition, there was an excess of null C4 allotypes (C4 AQo or C4 BQo) in patients and a significant decrease of BfS allele. Finally, the most commonly observed phenotype was A1 B8 DR3 BfS C4AQoB1. These results confirm a strong association between major histocompatibility complex and primary membranous glomerulonephritis, raising the possibility of a susceptibility gene being necessary for the development of that disease.
Berthoux
F C
FC
Service de Néphrologie, dialyse et transplantation rénale, Hôpital Nord, CHRU, Saint-Etienne.
Berthoux
P
P
Hassan
A A
AA
Vacherot
C
C
Pomier
G
G
Laurent
B
B
Le Petit
J C
JC
D000328:Adult; D000368:Aged; D005260:Female; D005921:Glomerulonephritis / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012016:Reference Values
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II
Immunogénétique des glomérulonéphrites extramembraneuses primitives.