[Various recent findings concerning the formation, mechanism of action and significance of atrial natriuretic peptides (atriopeptins)].
The proatriopeptins consisting of 126 amino acids is formed and stored by the myocytes of the atria. In its disintegration among others develops the alpha-atriopeptins consisting of 28 amino acids, which in normal blood pressure and blood volume, respectively, is secreted only in small quantities. The content of alpha-atriopeptins in the plasma varies approximately between 4 and 12 pmol/l in the course of 24 hours, the half-life period amounts to 1 to 2 min. In an increase of the blood pressure in the atria and in tachycardia the output of alpha-atriopeptins increases. It is bound to receptors of the cells of the glomerular zone, the vessels, the hypothalamus and the kidneys and activates a guanylate cyclase. The main effects of the alpha-atriopeptins are an inhibition of the secretion of aldosterone, vasopressin and renin, a dilation of the arteries, an increase of the glomerular filtration as well as an increase of the sodium and water excretion. In certain diseases of the kidneys and the heart the content of alpha-atriopeptins in the plasma increases.
Kolb
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E
Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007668:Kidney / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects; D011498:Protein Precursors / Q000096:biosynthesis; D015384:Zona Glomerulosa / Q000187:drug effects
D011498:Protein Precursors; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D006854:Hydrocortisone
Einige neuere Erkenntnisse zur Bildung, zum Wirkungsmechanismus und zur Bedeutung der atrialen natriuretisch wirksamen Peptide (Atriopeptide).