[Antitumor activity of polyanion and its application for drug delivery system of antitumor drugs].
Polyanionid copolymer of divinyl ether and maleic anhydride (DIVEMA) with narrow molecular weight distribution was synthesized and tested of its antitumor activity. DIVEMA showed a significant antitumor activity against colon 26 adenocarcinoma and FSaI fibrosarcoma transplanted in syngenic mice. Furthermore, DIVEMA was used as a polymeric drug carrier of antitumor drugs to reduce side effects and enhance the antitumor activity of the drugs. Adriamycin and neocarzinostatin were attached covalently to DIVEMA and the polymeric conjugates showed higher antitumor activity than the corresponding mother drugs against P 388 leukemic mice.
Hirano
T
T
Dept. of Bioengineering, University of Tsukuba.
Ohashi
S
S
Todoroki
T
T
Inaba
M
M
Tsukagoshi
S
S
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D003110:Colonic Neoplasms / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology*; D011713:Pyran Copolymer / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D009353:Zinostatin / Q000008:administration & dosage / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004317:Doxorubicin; D004337:Drug Carriers; D046911:Macromolecular Substances; D000071228:Polyelectrolytes; D011108:Polymers; D011713:Pyran Copolymer; D009353:Zinostatin