title: Genetic and environmental influences on echocardiographically determined left ventricular mass in black twins.
abstract: Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P less than .01), systolic blood pressure (R2 = 0.21; P less than .01) and age (R2 = 0.10; P less than .05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 +/- 5) than DZ twins (17 +/- 11) for LVMI following adjustment for gender, systolic blood pressure and age (P less than .03). The intraclass correlation for MZ twins was 0.90 (P less than .01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age.
authors: Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
authors: G A
authors: GA
authors: Harshfield
authors: C E
authors: CE
authors: Grim
authors: C
authors: C
authors: Hwang
authors: D D
authors: DD
authors: Savage
authors: S J
authors: SJ
authors: Anderson
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D044383:Black People; D001794:Blood Pressure; D001830:Body Surface Area; D006332:Cardiomegaly / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D004200:Diseases in Twins; D004452:Echocardiography; D004734:Energy Metabolism; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D005082:Physical Exertion; D012044:Regression Analysis; D012737:Sex Factors; D014427:Twins / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*