[Sandoglobulin immunocorrection in trauma].
Twenty one patients with the long-term compression syndrome (LCS) and 12 patients with burns treated with sandoglobulin in combination with antibacterial therapy were followed up. The control groups included 14 and 18 patients, respectively. All the patients had wound infections. Increased or lowered respiratory burst of peripheral blood neutrophils and lowered contents of active T-lymphocytes were detected in the majority of the patients. The patients had also an increased respiratory burst of tissue homogenate in the primary focus. Sandoglobulin decreased the periods of normalization of the immunological indices, body temperature and leukogram shifts to the right. The most pronounced effect of the drug was recorded before radical operations, i.e. in the presence of acute microbial toxemia or in patients with severe and extended burns. The procedure of immunological monitoring developed by the authors rapidly estimates the indications to the use of sandoglobulin alone or in combination with other immunomodulators.
Belotskiĭ
S M
SM
Karlov
V A
VA
Gutsu
E V
EV
Alekseev
A A
AA
Filiukova
O B
OB
Dikovskaia
E S
ES
Lukoianova
T N
TN
Borisova
T G
TG
Abul'khanov
A R
AR
Shkrov
L O
LO
D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D001831:Body Temperature / Q000187:drug effects; D002056:Burns / Q000150:complications / Q000276:immunology / Q000628:therapy*; D015169:Colony Count, Microbial; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous; D007958:Leukocyte Count / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012774:Shock, Traumatic / Q000150:complications / Q000276:immunology / Q000628:therapy*; D013577:Syndrome; D013601:T-Lymphocytes / Q000187:drug effects
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
Immunokorrektsiia sandoglobulinom pri travme.