Plasma prolactin response to domperidone in acute schizophrenia and schizophreniform illness.
The prolactin (PRL) response to 20 mg of domperidone, a peripheral dopamine (DA) blocking agent, was evaluated in a group of 16 drug-free, acute, young schizophreniform and schizophrenic males and in a group of age-matched normal males. Although basal plasma PRL levels were normal, the PRL responses following domperidone were blunted in both patient groups. The PRL response was more blunted in the schizophreniform patients than in the schizophrenic patients. Possible explanations for these results include pharmacokinetic factors or abnormalities of the pituitary D2 DA receptors.
Nerozzi
D
D
Department of Experimental Medicine, University of Rome La Sapienza, Italy.
Magnani
A
A
Sforza
V
V
Scaramucci
E
E
Cerilli
M
M
Moretti
C
C
Frajese
G
G
Antonozzi
I
I
Meltzer
H Y
HY
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000187:drug effects; D004294:Domperidone; D006801:Humans; D008297:Male; D008889:Military Personnel / Q000523:psychology*; D011388:Prolactin / Q000097:blood*; D011618:Psychotic Disorders / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D011954:Receptors, Dopamine / Q000187:drug effects; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis*; D012565:Schizophrenic Psychology
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004294:Domperidone; D011388:Prolactin