title: Competitive interaction of three peroxidizing herbicides with the binding of [3H]acifluorfen to corn etioplast membranes.
abstract: The specific binding of the herbicide acifluorfen 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid to corn etioplast membranes is competitively inhibited by protoporphyrinogen IX, the substrate of protoporphyrinogen oxidase. Three other peroxidizing molecules, oxadiazon [5-terbutyl-3-(2,4-dichloro-5-isopropoxyphenyl)-1,3,4-oxadiazol -2-one], LS 82556 [(S)3-N-(methylbenzyl)carbamoyl-5-propionyl-2,6-lutidine], and M&B 39279 [5-amino-4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazol], also compete with acifluorfen for its binding site. The four herbicides thus bind to the same site, or to closely located sites, on the enzyme protoporphyrinogen oxidase.
authors: Laboratoire des Herbicides, INRA, Dijon, France.
authors: R
authors: R
authors: Varsano
authors: M
authors: M
authors: Matringe
authors: N
authors: N
authors: Magnin
authors: R
authors: R
authors: Mornet
authors: R
authors: R
authors: Scalla
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D004237:Diuron / Q000494:pharmacology; D006540:Herbicides / Q000378:metabolism* / Q000494:pharmacology; D009536:Niacinamide / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D009579:Nitrobenzoates / Q000378:metabolism*; D010069:Oxadiazoles / Q000378:metabolism / Q000494:pharmacology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D044925:Oxidoreductases Acting on CH-CH Group Donors; D010944:Plants / Q000378:metabolism*; D050768:Protoporphyrinogen Oxidase; D011720:Pyrazoles / Q000378:metabolism / Q000494:pharmacology; D003313:Zea mays
chemical_list: D006540:Herbicides; D009579:Nitrobenzoates; D010069:Oxadiazoles; D011720:Pyrazoles; C058904:M&B 39279; D009536:Niacinamide; C058906:LS 82-556; D004237:Diuron; C012466:oxadiazon; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; D050768:Protoporphyrinogen Oxidase; C018425:acifluorfen