[In vitro effects of Fagaro xanthoxyloïdes Lam. on drepanocytic erythrocytes].
Study of the effect of acquious extract of Fagara xanthoxyloids Lam on the red blood corpuscles of 17 drepanocytics (SS) and 3 carriers of the trait (AS) showed drepanocyte reversibility with a residual level of 7%, an increase in the haemoglobin jellification time to 25 mn. 15 sec. (as compared to 9 mn. 57 sec.) and a shortening of red corpuscle filtration time from the normal 24.65 sec. to 9.6 sec. In a way as yet not understood, Fagara, like pentoxiphyllin, improves the rheological properties of drepanocytary blood.
Thiam
D
D
Service d'Hématologie-Immunologie, Université Cheikh Anta DIOP de Dakar.
Bako
R
R
Seck Fall
K
K
Diakhate
L
L
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004913:Erythrocytes, Abnormal / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts
Les effets in vitro du Fagara xanthoxyloïdes Lam. sur les érythrocytes drépanocytaires.