4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate receptor complex.
Harrison
B L
BL
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
Baron
B M
BM
Cousino
D M
DM
McDonald
I A
IA
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D005998:Glycine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007736:Kynurenic Acid / Q000378:metabolism; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013331:Strychnine / Q000494:pharmacology*
D011804:Quinolines; D016194:Receptors, N-Methyl-D-Aspartate; C066612:4-((carboxymethyl)oxy)-5,7-dichloroquinoline-2-carboxylic acid; C066613:MDL 100748; D007736:Kynurenic Acid; D013331:Strychnine; D005998:Glycine