Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as determined by microdialysis perfusion with NSD-1015.
Reduced steady state formation of dihydroxyphenylalanine (DOPA) (47%) was found in the nucleus accumbens (N. ACC) of rats treated with ten days of repeated cocaine (10 mg/kg, i.p.) as compared to saline controls after NSD 1015 perfusion (10(-4) M) by microdialysis. In addition, prior to NSD 1015 perfusion, basal extracellular levels of the dopamine metabolite, dihydroxyphenylacetic acid (DOPAC) in the N. ACC were 33% lower in the chronic cocaine-treated animals. The results indicate the rate of dopamine synthesis in the N. ACC is significantly reduced by repeated cocaine administration.
Brock
J W
JW
Department of Chemistry, Emory University, Atlanta, GA 30322.
Ng
J P
JP
Justice
J B
JB
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003956:Dialysis / Q000379:methods; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D006834:Hydrazines; D015102:3,4-Dihydroxyphenylacetic Acid; D004295:Dihydroxyphenylalanine; C004297:3-hydroxybenzylhydrazine; D003042:Cocaine; D004298:Dopamine