Antibacterial activity of combined cefotaxime and desacetyl-cefotaxime against aerobic and anaerobic gram-negative bacilli.
Synergy between cefotaxime and desacetyl-cefotaxime was evaluated against 12 strains (9 Enterobacteriaceae and 3 Bacteroides fragilis) by the chequerboard technique. A 1:1 combination of cefotaxime and desacetyl-cefotaxime was synergistic against two-thirds of the 12 strains tested. The in vitro activity of the combination was compared with that of four other beta-lactam antibiotics against 96 recent clinical isolates: 78 Enterobacteriaceae, 8 Haemophilus influenzae, 10 B. fragilis. The MICs of the combination for Gram-negative bacilli were similar to those of ceftazidime. Cefotaxime/desacetyl-cefotaxime was more active than cefotetan, cefonicid and piperacillin against Enterobacteriaceae and H. influenzae.
Marone
P
P
Institute of Infectious Diseases, IRCCS Pol. S. Matteo, University of Pavia, Italy.
Navarra
A
A
Monzillo
V
V
Traverso
A
A
D001441:Bacteroides fragilis / Q000187:drug effects*; D015790:Cefonicid / Q000494:pharmacology; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015313:Cefotetan / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods; D010878:Piperacillin / Q000494:pharmacology
D015313:Cefotetan; D015790:Cefonicid; C029281:desacetylcefotaxime; D002442:Ceftazidime; D002439:Cefotaxime; D010878:Piperacillin