[Cross-sectional study of elementary school children for assessing suspected effects of regional hemato-toxic environmental pollutants].
To investigate the suspicion of an increased incidence of leukopenia in school children living in the more industrialised northern region of the city of Essen, blood counts of these children were compared to those of pupils from the southern region in a two-phased study. In 469 1st and 2nd grade children, neither the mean leukocyte count nor the number of individual abnormal results differ between the two regional groups. A difference in the mean hemoglobin value found in the first series of investigations could not be reproduced in a control study of 255 children, the analysis of the data pointing to a methodological reason for the difference. Feasibility, planning and interpretation of results of such a cross-sectional study are discussed.
Kremens
B
B
Zentrum für Kinderheilkunde, Abteilung für Hämatologie und Onkologie der Universität Essen GHS.
Kundt
R
R
Hirche
H
H
Walde
G
G
Roggenbuck
U
U
Gräfe
E
E
Havers
W
W
D000393:Air Pollutants / Q000009:adverse effects*; D001772:Blood Cell Count / Q000187:drug effects*; D002648:Child; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring / Q000379:methods*; D005260:Female; D005858:Germany; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D012307:Risk Factors
D000393:Air Pollutants
Querschnittsuntersuchung an Grundschulkindern zur Klärung eines Verdachts auf Auswirkungen von regionalen hämatotoxischen Umweltnoxen.