Electrical control of gastric emptying in denervated and reinnervated canine stomach: a pilot study.
Gastric emptying of solids is abnormally slow after vagotomy. To determine whether it was possible to accelerate emptying by electrical stimulation either of the gastric wall directly or of a "foreign" nerve brought in to reinnervate the stomach, eight dogs underwent truncal vagotomy (TV); five of the dogs received intercostal nerve muscle pedicle (NMP) implants. Gastric atony was demonstrated postoperatively in all animals up to 4 months later by means of radiological contrast studies. After allowing time for neurotization to occur (mean 78 days), the cervical vagi were stimulated to confirm that TV was complete. Gastric peristalsis, intraluminal pressures, and emptying were assessed during stimulation of the NMPs and of the gastric wall, followed by sacrifice for histologic study. Neither reinnervation alone nor stimulation of the NMPs improved emptying. Although viable somatic nerve was found in the gastric wall, nerve sprouting was not. By contrast, stimulation of the gastric wall with trains of pulses (20 Hz, 2-10 ms, 2-5 mA) evoked peristalsis in all animals. We conclude that somatic nerve tissue cannot produce functional reinnervation of a visceral organ; however, direct muscular stimulation can accelerate gastric emptying after TV.
Grundfest-Broniatowski
S
S
Department of General Surgery, Cleveland Clinic Foundation, Ohio 44195-5043.
Davies
C R
CR
Olsen
E
E
Jacobs
G
G
Kasick
J
J
Chou
S M
SM
Nosé
Y
Y
Hermann
R E
RE
D000009:Abdominal Muscles / Q000294:innervation; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D007367:Intercostal Nerves / Q000502:physiology / Q000601:surgery*; D010865:Pilot Projects; D013270:Stomach / Q000294:innervation*; D013900:Thoracic Nerves / Q000601:surgery*; D015167:Vagotomy, Truncal