Monoamine oxidase and oxidative stress at dopaminergic synapses.
Increased oxidation of dopamine by monoamine oxidase (MAO) in the striatum is associated with an oxidant stress, expressed as a rise in the level of oxidized glutathione. Oxidation of glutathione is suppressed by MAO inhibitors, such as deprenyl and clorgyline. These observations related to Parkinson's disease and to the clinical trial of deprenyl as an agent that may retard progression of the disease.
Cohen
G
G
Department of Neurology, Mount Sinai School of Medicine, New York.
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism*; D013378:Substantia Nigra / Q000201:enzymology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D012642:Selegiline; D007980:Levodopa; D012110:Reserpine; D008995:Monoamine Oxidase; D005980:Glutathione Reductase; D005978:Glutathione; D006220:Haloperidol; D003010:Clorgyline; D004298:Dopamine