title: Atrial natriuretic peptide in the subfornical organ reduces drinking induced by angiotensin or in response to water deprivation.
abstract: Three experiments tested whether the subfornical organ (SFO) could be a site of action for the antidipsogenic effects of atrial natriuretic peptide (ANP) in rats. Pretreatment with 100, 230, or 500 pmol ANP in the SFO reduced drinking induced by 10 pmol angiotensin II in the SFO. Drinking in response to water deprivation was reduced by ANP in rats having cannulas in or near the SFO, but not in rats having cannulas distant from the SFO or in the ventricles. Finally, ANP had no effect on eating or drinking after food deprivation, suggesting that the rats in the other experiments were not acutely incapacitated. The SFO may mediate the central effects of ANP on drinking induced by angiotensin or in response to water deprivation and could play a similar role in the central effects of ANP on salt appetite, diuresis, vasopressin secretion, and blood pressure.
authors: Department of Psychology, University of Washington, Seattle 98195.
authors: K J
authors: KJ
authors: Ehrlich
authors: D A
authors: DA
authors: Fitts
mesh_terms: D000804:Angiotensin II / Q000187:drug effects*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013356:Subfornical Organ / Q000187:drug effects*; D013894:Thirst / Q000187:drug effects*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor