[Proteolytic and collagenolytic activities of experimental methylcholanthrene-induced fibrosarcoma].
Rat fibrosarcoma induced by methylcholanthrene exhibited proteolytic activity against type I collagen at acidic range of pH values. This activity was not only collagen-specific as it was able to cause hemoglobin degradation to low-molecular products. No collagenolytic activity was found near physiological values pH.
Tryniszewska
E A
EA
Zakład Biochemii Akademii Medycznej, Białymstoku.
Bańkowski
E
E
D000818:Animals; D002403:Cathepsins / Q000378:metabolism*; D002850:Chromatography, Gel; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D003470:Culture Media; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D005354:Fibrosarcoma / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains; D012983:Soft Tissue Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*
D003470:Culture Media; D008748:Methylcholanthrene; D003094:Collagen; D002403:Cathepsins
Aktywność proteolityczna i kolagenolityczna doświadczalnego włókniakomiesaka indukowanego metylocholantrenem.