[Efficacy of a combination of dioxidine with beta-lactam antibiotics in the prevention and treatment of purulent-inflammatory complications].
Schemes for prevention and treatment of purulent inflammatory complications were developed on the basis of in vitro studies on antimicrobial activity of dioxidine and 7 beta-lactam antibiotics such as mezlocillin, carbenicillin, ampicillin, cefotaxime, cefoxitin, cefuroxime and cephalothin under conditions of aero- and anaerobiosis with an account of the isolated microflora, its sensitivity to antibacterial agents and conditions required for vital activity of obligate anaerobes in humans, i.e. decreased partial oxygen pressure, low oxidation-reduction potentials and high tissue concentrations of carbon dioxide. The use of dioxidine in combination with the antimicrobial drugs enabled one to decrease the number of cases with purulent inflammatory complications after large intestine esophagoplasty to 30.4 per cent against 67.5 per cent in the control group of the patients untreated preventively with the antibacterial drugs. The number of cases with similar complications after gastrectomy amounted to 16.1 per cent against 62 per cent in the control. The use of dioxidine+ in combination with ampicillin and cefotaxime in treatment of purulent necrotic affections of the foot in patients with diabetes mellitus enabled one to increase the number of satisfactory outcomes by 32 per cent, to decrease the number of high amputations by 21.9 per cent and to lower the number of deaths more than 2-fold as compared to the results in the control group of the patients subjected to chemotherapy based on sensitivity of the aerobic microflora alone.
Bogomolova
N S
NS
Bol'shakov
L V
LV
Drachennikova
A A
AA
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002245:Carbon Dioxide / Q000378:metabolism; D048909:Diabetes Complications; D004359:Drug Therapy, Combination; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D009336:Necrosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D011810:Quinoxalines / Q000008:administration & dosage*; D013492:Suppuration / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011810:Quinoxalines; D047090:beta-Lactams; D002245:Carbon Dioxide; C001077:dioxidine; D010100:Oxygen
Effektivnost' kombinatsii dioksidina s betalaktamnymi antibiotikami pri profilaktike i lechenii gnoĭno-vospalitel'nykh oslozhneniĭ.