Increased severity of fetal hemolytic disease with known rhesus alloimmunization after first-trimester transcervical chorionic villus biopsy.
Fetomaternal hemorrhage secondary to chorionic villus biopsy has the potential to accelerate fetal hemolytic disease in the pregnant patient previously sensitized to red cell antigens. A case of poor fetal outcome after first-trimester transcervical chorionic villus sampling in an alloimmunized patient is reported. An increase in antibody titers was associated with the demise of a hydropic fetus early in the second trimester. Maternal red cell alloimmunization is suggested as an absolute contraindication for chorionic villus sampling performed for genetic indications.
Moise
K J
KJ
Prenatal Diagnostic Center, Baylor College of Medicine, Houston, Tex.
Carpenter
R J
RJ
D000328:Adult; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D000075202:Contraindications; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005331:Fetomaternal Transfusion / Q000209:etiology*; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012203:Rh Isoimmunization