Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells.
Hyperthermia (42-44 degrees C) and photosensitizing therapy can destroy S180 tumor cells, reduce malignant ascites and prolong the survival times of mice with carcinomas. The highest curative effect was observed when using a combination of the two treatments. Heating to 44 degrees C has a greater destructive effect on tumor cells than has heating to 42 degrees C. The results show that this is due to a synergistic interaction between these two treatments. The fluorescence spectrum of S180 cells was determined before and after treatment, and the indication was that the synergistic effect is probably related to a new fluorescence product; the greater the intensity of the new fluorescence, the more marked the synergy of hyperthermia and photosensitizing therapy. The maximum emission wavelength was 460nm (excitation wavelength 370nm).
Fan
X J
XJ
Cancer Institute, CAMS, Beijing.
Cao
E H
EH
Chi
S J
SJ
Wang
Y X
YX
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D017324:Hematoporphyrin Derivative; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007834:Lasers; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative