Increase of transferrin binding induced by an alkyl-lysophospholipid in breast cancer cells.
The effect of ET-18-OCH3 on transferrin (Tf) binding in human breast cancer cell lines, MCF-7, ZR-75-1 and BT-20, and mouse fibroblast, Balb/c 3T3, was investigated. Pretreatment with 3-25 micrograms/ml ET-18-OCH3 increased the Tf binding at 37 degrees C and 4 degrees C in all cell lines tested. In MCF-7, both the affinity and the number of Tf binding sites were increased by ET-18-OCH3. These observations are of interest with respect to the action of ET-18-OCH3 on cell surface receptors.
Kosano
H
H
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Takatani
O
O
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002460:Cell Line; D005260:Female; D006801:Humans; D010742:Phospholipid Ethers / Q000494:pharmacology*; D011990:Receptors, Transferrin / Q000187:drug effects / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D000970:Antineoplastic Agents; D010742:Phospholipid Ethers; D011990:Receptors, Transferrin; D014168:Transferrin; C026659:edelfosine