Reversibility of the effect of LHRH agonists and other antiandrogenic hormones on the testis: a histomorphometric study.
Changes in testicular morphology are quantified in patients with metastatic prostatic cancer, treated with LHRH agonist Buserelin and compared with testes of young transsexuals and patients with metastatic prostatic cancer treated with orchidectomy only. No significant changes within 18 months were seen, suggesting reversibility of LHRH agonist effects on testicular morphology in this time period. Histomorphometrics of the testis are useful to quantify these changes.
Kisman
O K
OK
Department of Urology, Free University Hospital, Amsterdam, The Netherlands.
de Voogt
H J
HJ
Baak
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002064:Buserelin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D002064:Buserelin