Rearrangement of the beta T-cell receptor gene in a monocytoid B-cell lymphoma.
We describe an unusual case of monocytoid lymphoma displaying a rearrangement of the T-cell receptor beta-chain gene associated with a rearrangement of the immunoglobulin heavy-chain gene, and of the lambda light-chain gene. This lymphoma was morphologically similar to previous cases in the literature, and was clinically of low grade. The lymphoma expressed the lambda light chain, HLA-DR, CD21, and CD22. Though the B-cell lineage of this lymphoma seems very likely, the genotypic profile raises a cautionary note regarding the supposed high stage of differentiation of monocytoid lymphomas.
Xerri
L
L
Laboratoire d'Anatomie Pathologique, Centre Anti-Cancéreux, Marseille, France.
Horschowski
N
N
Lejeune
C
C
Carcassonne
Y
Y
Hassoun
J
J
D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D007147:Immunoglobulin Light Chains / Q000276:immunology; D007146:Immunoglobulin lambda-Chains / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008875:Middle Aged; D010641:Phenotype
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains