title: [Experimental cutaneous leishmaniasis. III. Histopathological aspects of the developmental behavior of the cutaneous lesion induced in Cebus apella (Primates: Cebidae) by Leishmania (Viannia) lainsoni, L. (V.) braziliensis and L. (Leishmania) amazonensis].
abstract: We have studied the histopathological aspects related to the evolution of cutaneous lesions experimentally produced in the monkey Cebus apella (Primates: Cebidae) by Leishmania (V.) lainsoni, L. (V.) braziliensis and L. (L.) amazonensis. Microscopical examination of a series of biopsies obtained from these animals showed the kinetics of the cutaneous lesions regarding three species of Leishmania inoculated, as follows: 1) an initial non-specific chronic inflammatory infiltrate; 2) macrophagic nodules; 3) necrosis of parasitized phagocytic cells; 4) epitheliode granuloma; 5) absorption of the necrotic area (sometimes forming "foreign-body granuloma"); 6) a non-specific residual inflammatory infiltration; and 7) cicatrization. These pathological processes are, of course, responsible for both development and resolution of the leishmaniotic lesion. We also discuss some immunopathological mechanisms probably related with the sequential events, and that could be also responsible for the different clinical aspects found in man.
authors: Seção de Parasitologia, Instituto Evandro Chagas (Fundação SESP), Belém, Pará, Brasil.
authors: F T
authors: FT
authors: Silveira
authors: M A
authors: MA
authors: Moraes
authors: R
authors: R
authors: Lainson
authors: J J
authors: JJ
authors: Shaw
mesh_terms: D000818:Animals; D001706:Biopsy; D002428:Cebus; D004195:Disease Models, Animal; D005260:Female; D007892:Leishmania braziliensis; D007894:Leishmania mexicana; D016773:Leishmaniasis, Cutaneous / Q000473:pathology*; D008297:Male
vernacular_title: Leishmaniose cutânea experimental. III--Aspectos histopatológicos do comportamento evolutivo da lesão cutânea produzida em Cebus apella (Primates: Cebidae) por Leishmania (Viannia) lainsoni, L. (V.) braziliensis E L. (Leishmania) amazonensis.