title: An evaluation of the "in vivo" and "in vitro" biological reaction and mechanical features of carbon fibre composites.
abstract: Tissue reaction to an epoxy resin-carbon fibre composite was tested "in vivo" and "in vitro" in order to evaluate this material as an alternative to metal alloys for clinical use in orthopaedic surgery. While the "in vitro" tests suggest a mild toxic effect of the composite on cells, good biocompatibility "in vivo" was observed when debris are not generated. The mechanical tests compared the composite and stainless steel plates, confirming the expected values for static strength and elastic modulus, revealing, however, the formation of long needles of carbon fibre following breakage of the plate.
authors: Clinica Ortopedica dell'Università di Bologna, Istituto Ortopedico Rizzoli, Bologna.
authors: A
authors: A
authors: Sudanese
authors: G
authors: G
authors: Ciappetti
authors: N
authors: N
authors: Baldini
authors: S
authors: S
authors: Stea
authors: D
authors: D
authors: Ciaroni
authors: D
authors: D
authors: Dallari
authors: A
authors: A
authors: Toni
authors: A
authors: A
authors: Giunti
mesh_terms: D000818:Animals; D001860:Bone Plates; D002244:Carbon / Q000737:chemistry / Q000633:toxicity*; D000077482:Carbon Fiber; D002478:Cells, Cultured / Q000187:drug effects; D004338:Drug Combinations; D004853:Epoxy Resins / Q000737:chemistry / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects; D000882:Haplorhini; D008422:Materials Testing / Q000379:methods; D011208:Powders; D011817:Rabbits; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D000077482:Carbon Fiber; D004338:Drug Combinations; D004853:Epoxy Resins; D011208:Powders; D002244:Carbon