[Regulatory mechanism of the cytoplasmic pH by H(+)-adenosinetriphosphatase].
Nature prefers simplicity. Streptococcal cytoplasmic pH is regulated in a simple biological manner: change in the amount of the adenosinetriphosphatase (H(+)-ATPase). This enzyme is identical to the F0F1-complex of oxidative phosphorylation, which synthesizes adenosinetriphosphate in mitochondria and most of bacteria, whereas it is used as a regulator of the cytoplasmic pH in streptococci which have no respiratory chain. Eukaryotes use the another type of H(+)-ATPase to regulate the internal pH. Thus, the evolutional process of H(+)-ATPase is quite interesting.
Kobayashi
H
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Faculty of Pharmaceutical Sciences, Chiba University, Japan.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D003593:Cytoplasm / Q000378:metabolism*; D013293:Enterococcus faecalis / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008928:Mitochondria / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000378:metabolism / Q000502:physiology*
D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases