title: The ultrastructure of the abdominal lymph nodes cortex in rats during primary and secondary immune response (a special reference to dendritic reticulum cells and interdigitating cells).
abstract: The stimulation of coeliac rat lymph nodes was performed by intraperitoneal injections of typhoid vaccine and was unique for the primary immune response and repeated after 6 weeks for the secondary response. The light and electron microscopic observations showed for the primary response, an early germinal center reaction, which might be accounted for by a background of continuous stimulation of the coeliac nodes, stemming from the digestive tract. The dendritic reticulum cells (DRC), considered typical for the B area, were located at the borderline between the germinal center and the mantle zone. Their cytoplasmic extensions penetrated the lymphocyte-lymphoblastic center, surrounding most of the germinal center cells. The marginal zone and the paracortex reacted as a whole, the interdigitating cells (IDC) being the dominant feature. An explanation would be that the marginal zone can be penetrated by T cells and connected IDCs, thus, the B and T areas seem to be largely interspersed. The results suggest that IDCs are cells of direct monocytic origin.
authors: Laboratory of Electron Microscopy, Victor Babes Institute, Buharest, Romania.
authors: E
authors: E
authors: Mandache
authors: A
authors: A
authors: Negoescu
mesh_terms: D000005:Abdomen; D000818:Animals; D000917:Antibody Formation; D003713:Dendritic Cells / Q000648:ultrastructure*; D008198:Lymph Nodes / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains