title: The p38 and p34 polypeptides of growth cone particle membranes are the alpha- and beta-subunits of G proteins.
abstract: Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p34. Antibodies specific for the alpha- and beta-subunits of G proteins recognize p38 and p34, respectively, on immunoblots following one- and two-dimensional electrophoretic separation. That G protein subunits comprise major species of GCP membrane-associated polypeptides suggests a role for G proteins in transmembrane signaling in nerve growth cones.
authors: Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235-9050.
authors: B T
authors: BT
authors: Edmonds
authors: C R
authors: CR
authors: Moomaw
authors: J T
authors: JT
authors: Hsu
authors: C
authors: C
authors: Slaughter
authors: L
authors: L
authors: Ellis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000737:chemistry*; D001921:Brain / Q000196:embryology; D001923:Brain Chemistry / Q000502:physiology; D019204:GTP-Binding Proteins / Q000737:chemistry*; D008565:Membrane Proteins / Q000032:analysis*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D019204:GTP-Binding Proteins