Cost effectiveness of routine gonadotropin and androgen measurements in hirsute women.
Many physicians routinely measure the gonadotropins PRL, LH, and FSH and the androgens dehydroepiandrosterone (DHEA), androstenedione (ADIONE), and testosterone, as well as testosterone's biologically active fractions in the evaluation of hirsute women. Is this cost effective? To answer this question, 38 consecutive premenopausal hirsute women were evaluated. Two women each had minor elevations in PRL and FSH, and 11 had minor elevations in LH. Three women had minor elevations in the LH/FSH ratio, and only one was above a ratio of 3, believed to be indicative of polycystic ovarian syndrome. Because these gonadotropin elevations did not correlate with the androgens measured and were of no value in the diagnosis or management of these women, they were not believed to be cost effective. Their routine measurements should be abandoned.
Helfer
E L
EL
Endocrinology-Metabolism Department, Hahnemann University, Philadelphia, Pennsylvania.
Miller
J L
JL
Rose
L I
LI
D000328:Adult; D000735:Androstenedione / Q000097:blood*; D003362:Cost-Benefit Analysis; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006628:Hirsutism / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000503:physiopathology; D015994:Incidence; D007986:Luteinizing Hormone / Q000097:blood*; D009839:Oligomenorrhea / Q000097:blood / Q000503:physiopathology; D011388:Prolactin / Q000097:blood*; D011446:Prospective Studies
D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone