[Inhibitors of blood coagulation in vascular occlusion of the retina and optic nerve].
The influence of a disturbed hemostasis as one of the causes of retinal or ciliary vascular occlusions is still controversial. Antithrombin III, protein C and its cofactor protein S were investigated in 25 patients; 14 of them with a retinal vein occlusion, five showed an occlusion of retinal arteries and six of ciliary arteries. Patients with a preceding thromboembolic disease were excluded from the investigations. The mean values (+/- SEM) of antithrombin III (12.1 IU/ml +/- 0.4), protein C (116% +/- 4), total protein S (102% +/- 3) and free protein S (46% +/- 2) were equivalent to the mean values of a normal population. Neither does a defect or a lack of coagulation inhibitors have an essential influence on the development of an isolated retinal or ciliary vascular occlusion nor does the local occlusive vascular disorder influence the activity of systemic inhibitors.
Krüger
K
K
Universitäts-Augenklinik, Freiburg.
Witt
I
I
D000368:Aged; D000990:Antithrombin III / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply*; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000378:metabolism*; D017293:Protein S; D015356:Retinal Artery Occlusion / Q000097:blood*; D012170:Retinal Vein Occlusion / Q000097:blood*
D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III
Inhibitoren der Gerinnung bei Gefässverschlüssen der Netzhaut und des Sehnerven.