title: Symptomatic native arterial occlusions: early experience with "over-the-wire" thrombolysis.
abstract: "Over-the-wire" thrombolysis was successfully accomplished in eight patients with symptomatic lower-extremity ischemia. The authors used a 5-F catheter with multiple side holes designed to pulse-spray urokinase directly over the guidance of a 0.035-inch guide wire. The mean occlusion length was 11.5 cm (range, 5-27 cm). Complete thrombolysis was achieved after delivery of a mean of 480,000 IU of urokinase in a mean infusion time of 48 minutes. One embolic complication was successfully treated with the catheter-wire system. No bleeding complications occurred. Over-the-wire thrombolysis is an alternative method of administering urokinase for the treatment of arterial occlusions.
authors: Department of Radiology, Veterans Administration Medical Center, Milwaukee, WI 53295.
authors: M W
authors: MW
authors: Mewissen
authors: P L
authors: PL
authors: Minor
authors: G A
authors: GA
authors: Beyer
authors: E O
authors: EO
authors: Lipchik
mesh_terms: D001157:Arterial Occlusive Diseases / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000098:blood supply*; D015912:Thrombolytic Therapy / Q000295:instrumentation / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator