[A simple method of synthesis of 3-acetyl-5-(D-arabino-tetrahydroxybutyl)-2-methylpyrrole].
The reaction of D-fructose with ammonium carbonate and 2,4-pentanedione leads in one step to 3-acetyl-5-(D-arabino-tetrahydroxybutyl)-2-methylpyrrole. This compound has been found to display anticancer activity.
Rózański
A
A
Zakładu Chemii Organicznej Akademii Medycznej, Białymstoku.
Bielawski
K
K
Bołtryk
J
J
Bartulewicz
D
D
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D005632:Fructose / Q000494:pharmacology; D007202:Indicators and Reagents / Q000494:pharmacology; D008722:Methods; D010422:Pentanones / Q000494:pharmacology; D014255:Trichothecenes / Q000138:chemical synthesis / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D002254:Carbonates; D007202:Indicators and Reagents; D010422:Pentanones; D014255:Trichothecenes; D005632:Fructose; C008790:acetylacetone; C032865:VER I; C040502:ammonium carbonate
Prosta metoda syntezy 3-acetylo-5-(D-arabino-tetrahydroksybutylo)-2-metylopirolu.