Genetic polymorphism of complement factor H in cattle.
Bovine factor H was found to be polymorphic by the combined techniques of SDS-polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons. Family studies demonstrated Mendelian segregation of variants S and F. The data indicate that these genetic variants of bovine factor H are encoded by two codominant alleles at a single autosomal locus.
Tabel
H
H
Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada.
Groat
H J
HJ
Kraay
G J
GJ
Aston
W P
WP
D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics*; D003180:Complement C3b Inactivator Proteins / Q000032:analysis / Q000235:genetics*; D017242:Complement Factor H; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005787:Gene Frequency; D015151:Immunoblotting; D008297:Male; D008970:Molecular Weight; D011110:Polymorphism, Genetic
D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H