title: Cutaneous stimulation regulates blood flow in cerebral cortex in anesthetized rats.
abstract: The effect of noxious or innocuous mechanical stimulation of cutaneous areas (face, forelimb and paw, back, hindlimb and paw) on cerebral blood flow in cortex was examined with laser Doppler flowmetry in anesthetized rats. Pinching of the face, forepaw and hindpaw for 15 s produced significant increases of systemic blood pressure and of cortical blood flow, whereas pinching of the back or brushing of any cutaneous area produced no significant changes in either parameter. Following spinal transection at the first thoracic level, the blood pressure response to forepaw pinching was suppressed, whereas the increase in cortical blood flow still took place. Thus the results suggest that the increase in cortical blood flow following cutaneous noxious stimulation is, in part at least, independent of changes in blood pressure and of any concomitant vasodilatation.
authors: Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors: T
authors: T
authors: Adachi
authors: K
authors: K
authors: Meguro
authors: A
authors: A
authors: Sato
authors: Y
authors: Y
authors: Sato
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D006221:Halothane / Q000494:pharmacology; D008297:Male; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012879:Skin Physiological Phenomena; D013116:Spinal Cord / Q000502:physiology
chemical_list: D006221:Halothane