[Participation of phospholipase A2 in uncoupling in rat liver mitochondria induced by products of lipid peroxidation].
Accumulation of lipid peroxidation products induced by cumol hydroperoxide (230 microM) results in the loss of the membrane potential only in calcium-loaded mitochondria. The phospholipase A2 inhibitor, p-bromophenylacylbromide, prevents mitochondrial uncoupling but has no effect on the accumulation of lipid peroxidation products.
Gogvadze
V G
VG
Bruetovetskiĭ
N N
NN
Zhukova
A A
AA
D000098:Acetophenones / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D004533:Egtazic Acid / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains
D000098:Acetophenones; D002084:Butylated Hydroxytoluene; D004533:Egtazic Acid; D010741:Phospholipases A; D054467:Phospholipases A2; C006821:4-bromophenacyl bromide; D002118:Calcium
Uchastie fosfolipazy A2 v indutsiruemom produktami perekisnogo okisleniia lipidov razobshchenii mitokhondriĭ pecheni krys.