title: Parkinson's disease, personality, and dopamine.
abstract: Clinicians have long observed an anecdotal association of Parkinson's disease with stoic, industrious, and inflexible personality traits, both premorbidly and after the onset of motor symptoms. In this study, using the Tridimensional Personality Questionnaire, we found significantly less novelty-seeking behavior (behavior thought to be dopamine-dependent) in Parkinson's disease patients than in matched controls, but no differences between groups in behaviors thought to be dependent on serotonin and norepinephrine. We discuss the literature and propose a mechanism that may explain the relationship between brain dopaminergic systems and personality in Parkinson's disease.
authors: Department of Psychiatry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903-0019.
authors: M A
authors: MA
authors: Menza
authors: N E
authors: NE
authors: Forman
authors: H S
authors: HS
authors: Goldstein
authors: L I
authors: LI
authors: Golbe
mesh_terms: D001143:Arousal / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010552:Personality Assessment / Q000706:statistics & numerical data; D010554:Personality Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics
chemical_list: D004298:Dopamine