Stimulus properties of tiflucarbine: a novel antidepressant agent.
Tiflucarbine is a structurally novel antidepressant that binds at central serotonin (5-HT) binding sites. There is also evidence that this agent is both a 5-HT1 and a 5-HT2 agonist. To further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-HT1A agonist 8-OH DPAT, the 5-HT2 agonist DOM, and the nonselective 5-HT agonist 5-OMe DMT from saline. Tiflucarbine resulted in partial generalization in the DOM-trained and in the 8-OH DPAT-trained animals. Although two-thirds of the animals were disrupted, 10 mg/kg of tiflucarbine resulted in stimulus generlization in the 5-OMe DMT-trained animals. It is concluded that tiflucarbine is most likely a nonselective 5-HT agonist.
Glennon
R A
RA
Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0540.
De Vry
J
J
Spencer
D G
DG
Glaser
T
T
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D007211:Indoles; D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C050288:tiflucarbine