Interference of parathion with mitochondrial bioenergetics.
The organophosphorus insecticide parathion depresses the phosphorylation efficiency of mitochondria as inferred from the decrease of RCR and ADP/O ratios. The transmembrane potential (delta psi) developed by energized mitochondria, and depolarization upon ADP addition are also decreased. Furthermore, repolarization is delayed and resumes at a slower rate. The inhibitory action of parathion on phosphorylation efficiency could be related with the following findings: (1) a direct effect on the succinate dehydrogenase-ubiquinone segment of the redox chain; (2) a direct action on the ATP synthetase complex; (3) partial inhibition of the phosphate transporter.
Moreno
A J
AJ
Departamento de Zoologia, Universidade de Coímbra, Portugal.
Madeira
V M
VM
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009243:NAD / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010278:Parathion / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D009840:Oligomycins; D009243:NAD; D010278:Parathion; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases