Antineoplastic properties of Maharishi-4 against DMBA-induced mammary tumors in rats.
Maharishi-4 (M-4), an ayurvedic food supplement, was tested for anticarcinogenic and anticancer properties against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% M-4-supplemented diet protected DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. The control animals who developed tumors when supplemented with M-4 diet for four weeks showed tumor regression in 60% of cases. There was no significant difference in the food intake or weight gain in rats who were on M-4-supplemented diet compared to control group. Possible mechanisms of action of M-4 are discussed.
Sharma
H M
HM
College of Medicine, Ohio State University, Columbus 43210.
Dwivedi
C
C
Satter
B C
BC
Gudehithlu
K P
KP
Abou-Issa
H
H
Malarkey
W
W
Tejwani
G A
GA
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D004744:Enkephalin, Methionine / Q000032:analysis; D004958:Estradiol / Q000097:blood; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D008515:Medicine, Ayurvedic; D010902:Pituitary Gland / Q000032:analysis; D010946:Plants, Medicinal; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000032:analysis
D000972:Antineoplastic Agents, Phytogenic; D004958:Estradiol; D015127:9,10-Dimethyl-1,2-benzanthracene; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D011388:Prolactin