4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid.
4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n - 6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.
Van Kuijk
F J
FJ
Chemistry Department, Montana State University, Bozeman 59717.
Holte
L L
LL
Dratz
E A
EA
D000447:Aldehydes / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction
D000447:Aldehydes; C063409:4-hydroxyhexenal; D004281:Docosahexaenoic Acids