title: The effects of dyadic combinations of endodontic medicaments on microbial growth inhibition.
abstract: In recent years dyadic combinations of endodontic medicaments have been used increasingly in clinical pediatric dentistry with little regard to the possibility of pharmacological antagonism of the components. In this investigation, a microbial growth inhibition assay was used to determine changes in antimicrobial activity in dyadic mixtures of endodontic medicaments. The combinations assayed were Ledermix (corticosteroid-antibiotic) and Calyxl (calcium hydroxide), Ledermix and Kri (iodoform), Kri and Calyxl, and formocresol and eugenol. All these compounds have antibacterial activity when used individually. In the dyadic combinations assayed, results showed that adding calcium hydroxide to another antibiotic preparation has deleterious effects on growth inhibition, and combining any two antimicrobial medicaments produces no additive or synergistic effects. It is concluded that it may be clinically advantageous to use endodontic medicaments in the dyadic combinations shown in this investigation.
authors: Dental School, University of Queensland, Brisbane, Australia.
authors: W K
authors: WK
authors: Seow
mesh_terms: D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002126:Calcium Hydroxide / Q000494:pharmacology; D002164:Camphor / Q000494:pharmacology; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D003707:Demeclocycline / Q000494:pharmacology; D004338:Drug Combinations; D005054:Eugenol / Q000494:pharmacology; D005566:Formocresols / Q000494:pharmacology; D006847:Hydrocarbons, Iodinated / Q000494:pharmacology; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013298:Streptococcus sanguis / Q000187:drug effects*; D014222:Triamcinolone Acetonide / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005566:Formocresols; D006847:Hydrocarbons, Iodinated; D012387:Root Canal Filling Materials; C036374:Kri paste; C031025:formocresol; D005054:Eugenol; D003707:Demeclocycline; D002164:Camphor; C001527:Ledermix; D014222:Triamcinolone Acetonide; C010473:iodoform; D002126:Calcium Hydroxide