[Intranuclear membranous inclusions in the CNS neurons of rats detectable after the administration of ascorbic acid and 6-hydroxydopamine].
Intranuclear membranous inclusions were found in neurons of the rat's cerebral cortex and caudate nucleus 2-21 days following the intraperitoneal injection of ascorbic acid (0.2 and 2.0 g/kg) or the intracisternal infusion of 6-hydroxydopamine (300 micrograms). The intranuclear inclusions were mostly round, occasionally irregular in shape, consisting of one or several concentric membranes; in addition, they were electron-lucid with the diameter of 0.2-0.5 microns, sometimes up to 1 micron. Possible relationship between the formation of intranuclear membranous inclusions and the acceleration of intranuclear metabolism, particularly lipid peroxidation processes, are discussed.
Grigor'ev
I P
IP
Otellin
V A
VA
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000648:ultrastructure; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D009498:Neurotoxins / Q000494:pharmacology*; D009685:Nuclear Envelope / Q000187:drug effects / Q000648:ultrastructure; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006892:Hydroxydopamines; D009498:Neurotoxins; D016627:Oxidopamine; D001205:Ascorbic Acid
Vnutriiadernye membrannye vkliucheniia v neĭronakh TsNS krys, obnaruzhivaemye posle vvedeniia askorbinovoĭ kisloty i 6-oksidofamina.