title: Synthesis and some reactions of 1-methyl-1H-2-cyanomethyl-imidazo[4,5-b]pyridine. Tuberculostatic activity of obtained compounds.
abstract: 1-Methyl-1H-2-cyanomethyl-imidazo[4,5-b]pyridine was synthesized and the reactivity of its CN and --CH2--groups was investigated. 5 H-Dipyrido[1,2-a: 3',2'd]imidazole derivatives were also prepared. Some of the obtained compounds were screened for their tuberculostatic activity.
authors: Department of Organic Chemistry, Medical Academy, Gdańsk, Poland.
authors: L
authors: L
authors: Bukowski
authors: M
authors: M
authors: Janowiec
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000995:Antitubercular Agents; D007093:Imidazoles; D009570:Nitriles; D011725:Pyridines