Examination of submandibular fluid in cystic fibrosis.
A novel collecting device was used to obtain pure submandibular saliva from control and Cystic Fibrosis (CF) individuals. Vitamin C stimulation induced a 2-fold increase in flow rate relative to resting; CF rates were lower under both conditions. Control and CF saliva differed in that stimulation did not result in increased Na+ and Cl- levels in CF saliva and that elevated levels of Ca2+ and PO4(2-) were observed in CF. The results imply altered electrolyte secretion in CF in response to a stimulus in vivo.
Davies
H
H
Dept. of Medical Biochemistry, University of Wales College of Medicine, Cardiff, U.K.
Bagg
J
J
Goodchild
M C
MC
McPherson
M A
MA
D000328:Adult; D003550:Cystic Fibrosis / Q000503:physiopathology*; D004573:Electrolytes / Q000378:metabolism; D006801:Humans; D012463:Saliva / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism*
D004573:Electrolytes