Transmembrane helical interactions and the assembly of the T cell receptor complex.
Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts. For one such pair, TCR-alpha and CD3-delta, their ability to assemble was encoded by their transmembrane domains. The specificity of this interaction suggests that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.
Manolios
N
N
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Bonifacino
J S
JS
Klausner
R D
RD
D000595:Amino Acid Sequence; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D017252:CD3 Complex; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D003062:Codon / Q000235:genetics; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D003062:Codon; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell