title: Immunoreactive atrial natriuretic factor in aqueous humor: its concentration is increased with high intraocular pressure in rabbit eyes.
abstract: Atrial natriuretic factor (ANF) concentration in the aqueous humor (AH) was studied in rabbits with experimental glaucoma induced by injecting alpha-chymotrypsin into the posterior chamber. In normal rabbit eyes, the ANF concentration in AH was 3.1 +/- 1.2 pg/ml (mean +/- SEM; n = 12), ranging from 0 to 5.8 pg/ml, whereas it was significantly higher in AH from glaucomatous rabbit eyes, being 81.0 +/- 9.8 pg/ml (n = 12). These findings were correlated with intraocular pressure (IOP), which was 13.0 +/- 2.4 mmHg (n = 12) in normal rabbit eyes and significantly greater in glaucomatous eyes: 24.4 +/- 3.0 mmHg (n = 12). Our data indicate that enhanced ANF release in AH during experimental glaucoma may play an important physiological role in modulating IOP.
authors: Diabetic, Hypertension and Obesity Unit, Hospital Universitario San Carlos, Ciudad Universitaria, Madrid, Spain.
authors: R
authors: R
authors: Fernandez-Durango
authors: A
authors: A
authors: Triviño
authors: J M
authors: JM
authors: Ramirez
authors: M
authors: M
authors: Garcia de Lacoba
authors: A
authors: A
authors: Ramirez
authors: J J
authors: JJ
authors: Salazar
authors: A
authors: A
authors: Fernandez-Cruz
authors: J
authors: J
authors: Gutkowska
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D002918:Chymotrypsin; D005123:Eye / Q000473:pathology; D005901:Glaucoma / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011817:Rabbits
chemical_list: D009320:Atrial Natriuretic Factor; D002918:Chymotrypsin