title: Down syndrome in Kuwait.
abstract: During a 7-year-period (1980-1986) trisomy 21 was confirmed in 635 cases (257 males and 278 females). There were 611 cases of trisomy 21 (96.2%), 12 of different translocations (1.9%), 9 of mosaicism (1.4%), and 3 with nonclassical karyotypes (0.5%). The frequency of chromosome aberrations in our study is compared to that of major world-wide cytogenetic surveys comprising 17,738 Down syndrome cases. These surveys showed that regular trisomy 21 constitutes 92.9%, translocations 4.3%, mosaicism 2.2%, and nonclassical karyotypes 0.5%.
authors: Kuwait Medical Gentics Centre, Maternity Hospital, Safat.
authors: S A
authors: SA
authors: al-Awadi
authors: T I
authors: TI
authors: Farag
authors: A S
authors: AS
authors: Teebi
authors: K K
authors: KK
authors: Naguib
authors: T S
authors: TS
authors: Sundareshan
authors: D S
authors: DS
authors: Murthy
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004314:Down Syndrome / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007730:Kuwait / Q000453:epidemiology; D008297:Male; D009030:Mosaicism; D014178:Translocation, Genetic