title: A point mutation of the rhodopsin gene in one form of retinitis pigmentosa.
abstract: The gene for autosomal dominant retinitis pigmentosa in a large pedigree of Irish origin has recently been found to be linked to an anonymous polymorphic sequence, D3S47 (C17), from the long arm of chromosome 3. As the gene coding for rhodopsin is also assigned to the long arm of chromosome 3 and is expressed in rod photoreceptors that are affected early in this blinding disease, we searched for a mutation of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa. We found a C----A transversion in codon 23 (corresponding to a proline----histidine substitution) in 17 of 148 unrelated patients and not in any of 102 unaffected individuals. This result, coupled with the fact that the proline normally present at position 23 is highly conserved among the opsins and related G-protein receptors, indicates that this mutation could be the cause of one form of autosomal dominant retinitis pigmentosa.
authors: Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors: T P
authors: TP
authors: Dryja
authors: T L
authors: TL
authors: McGee
authors: E
authors: E
authors: Reichel
authors: L B
authors: LB
authors: Hahn
authors: G S
authors: GS
authors: Cowley
authors: D W
authors: DW
authors: Yandell
authors: M A
authors: MA
authors: Sandberg
authors: E L
authors: EL
authors: Berson
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D002893:Chromosomes, Human, Pair 3; D003062:Codon; D004596:Electroretinography; D005136:Eye Proteins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010375:Pedigree; D010786:Photoreceptor Cells / Q000378:metabolism; D012168:Retinal Pigments / Q000235:genetics*; D012174:Retinitis Pigmentosa / Q000235:genetics* / Q000503:physiopathology; D012243:Rhodopsin / Q000235:genetics* / Q000502:physiology; D017299:Rod Opsins
chemical_list: D003062:Codon; D005136:Eye Proteins; D012168:Retinal Pigments; D017299:Rod Opsins; D012243:Rhodopsin