The effects of maternal diabetes on placental transfer of essential and non-essential fatty acids in the rat.
Studies were performed on the transfer of essential and non-essential non-esterified fatty acids across the in-situ perfused placenta in normal and diabetic rats in late gestation. Results indicated that increasing maternal glycaemia is associated with a decrease in the unidirectional transfer of both essential and non-essential fatty acids. This reduced transfer is dependent upon the uteroplacental blood flow, which is compromised in the diabetic animals. The transfer of essential fatty acid was always twofold that of non-essential fatty acids regardless of the total amount of lipid transferred, indicating a selective mechanism for the transfer of these moieties.
Honda
M
M
Division of Medicine, U.M.D.S., St. Thomas' Hospital, London.
Lowy
C
C
Thomas
C R
CR
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010920:Placenta / Q000503:physiopathology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D005228:Fatty Acids, Essential; D005230:Fatty Acids, Nonesterified; D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen