Nasopharyngeal carcinomas and malignant lymphomas: an immunohistochemical analysis of 74 cases.
Seventy-four cases of nasopharyngeal malignant neoplasms were analyzed immunohistochemically and classified into 16 lymphomas and 58 carcinomas. Eight lymphomas were of T-cell origin and eight were of B-cell origin. Although there were no significant differences in prognoses between patients with carcinoma and those with lymphoma, T-cell lymphomas resulted in a worse outcome. Five-year survival rates of T-cell and B-cell lymphoma were 12.5% and 75%, respectively. Polyclonal keratin and tissue polypeptide antigen were more sensitive and specific than other epithelial markers, and were positive in 97% (56 of 58) and 93% (54 of 58) of carcinomas, respectively. With regard to immunophenotypic analysis of malignant lymphomas, L26 to B-cells (88%) and UCHL1 to T-cells (100%) led to a satisfactory effect. Immunohistochemical investigations made possible differentiation of malignant lymphomas from a carcinoma and also aided in typing the latter.
Sugimoto
T
T
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hashimoto
H
H
Enjoji
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes; D002277:Carcinoma / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens; D008223:Lymphoma / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D018396:Mucin-1; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D013601:T-Lymphocytes
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D006649:Histocompatibility Antigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; D017493:Leukocyte Common Antigens