title: Neutrophils increase histamine contractions in pig coronary artery: a role for lipoxygenase products.
abstract: The possible role of neutrophils and the endothelium in the induction of hyperreactivity of the pig coronary artery to histamine was studied. In pig isolated coronary arteries histamine caused a concentration-dependent contraction; maximal contraction to histamine, however, was reduced in endothelium-denuded arteries. Pre-incubation of intact coronary arteries with isolated neutrophils did not affect the contractile response to histamine, while pre-incubation of endothelium-denuded arteries induced a hyperreactivity to histamine. This induction of hyperreactivity to histamine by neutrophils in pig coronary arteries seems to be mediated by lipoxygenase products, since it could be prevented by pre-incubation of the preparations with lipoxygenase inhibitors, but not with inhibitors of cyclo-oxygenase or with scavengers.
authors: Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.
authors: D
authors: D
authors: van Heuven-Nolsen
authors: G A
authors: GA
authors: Ten Have
authors: F P
authors: FP
authors: Nijkamp
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008084:Lipoxygenase / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D013552:Swine
chemical_list: D006632:Histamine; D008084:Lipoxygenase