Computer analysis of receptor-mediated endocytosis and exocytosis mechanisms: two pathways for the processing of TCR-CD3 receptor complexes of T lymphocytes.
A new mathematical model, based on a hypothesis in which two types of molecular complex which differ in their processing rate are involved in ligand binding at the cell surface, is proposed for the processing of ligand-receptor complexes. The model describes the kinetics of anti-human-CD3 monoclonal antibody endocytosis, exocytosis, and degradation by both normal and malignant T lymphocytes. The rates for the individual stages of processing of these ligand-receptor complexes are evaluated.
Kuznetsov
V A
VA
Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D017252:CD3 Complex; D003198:Computer Simulation; D004705:Endocytosis / Q000276:immunology*; D005089:Exocytosis / Q000276:immunology*; D006801:Humans; D008962:Models, Theoretical; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell