[The metabolism and DNA binding of 3H-fusarin C in rats].
In this paper, the distribution and elimination of 3H-Fusarin C (3H-FC) in rats and DNA-binding of FC in cultured explants of rat esophagus are reported. The radioactivity distribution in tissues was altered dynamically, and the highest levels of radioactivity were found in the intestine, stomach and liver after giving 3H-FC into the stomachs of rats. Kidney, bladder, esophagus and spleen followed. The radioactivity levels in the lung and brain were low. Radioactivity in the blood reached a peak three hours after giving 3H-FC to rats, but about 50% of the radioactivity remained in the blood even after 24 h. The total urinary excretion of radioactivity in rats was found to be about 30.7% within 48 h, and about 27.8% was present in the feces. Only 5.4% unchanged FC was excreted in the urine, while other metabolites of FC accounted for 94.6% of total urinary radioactivity. DNA-binding of FC occurred in rat esophageal explants.
Lu
F X
FX
Institute of Oncology, Beijing.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004947:Esophagus / Q000378:metabolism; D008297:Male; D011090:Polyenes / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011090:Polyenes; D004247:DNA; C041403:fusarin C