[Study of anti-ischemic action of carnitine chloride and its effects on the effectiveness of antianginal agents].
The experiments with models of myocardial infarction established that carnitine chloride reduced the size of an ischemic zone, prevented oxidative metabolism, lowered ATP and creatine phosphate levels, inhibited lactate and free fatty acid accumulation in the ischemic myocardium. Carnitine chloride in combination with nitrong and isoptin increased the anti-ischemic potency of the former.
Tishkin
V S
VS
Dunaev
V V
VV
Kryzhanovskiĭ
S A
SA
Riabinin
V A
VA
Favoritov
V N
VN
Danilovich
M I
MI
Kacharava
V G
VG
D000818:Animals; D002331:Carnitine / Q000008:administration & dosage / Q000627:therapeutic use*; D002415:Cats; D004796:Clinical Enzyme Tests; D004359:Drug Therapy, Combination; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use
D014700:Verapamil; D005996:Nitroglycerin; D002331:Carnitine
Issledovanie protivoishemicheskogo deĭstviia karnitina khlorida i ego vliianiia na éffektivnost' antianginal'nykh sredstv.