The pathologic and thermal effects of gold vapor laser photodynamic therapy on the larynx. Experimental study.
A gold vapor laser, which emits short pulses of light at a wavelength of 628 nm, was used to deliver varying amounts of energy (30 to 120 J/cm2) to the presensitized (dihematoporphyrin ether) canine larynx. Between 30 and 60 J/cm2, the larynx appeared normal, and when 70 to 100 J/cm2 was applied, only mild edema and erythema were seen. Simultaneously, a thermocouple probe was used and a 0.4 degrees C to 1.5 degrees C temperature rise found. Thus, the gold vapor laser seems capable of achieving the therapeutic photosensitizing effect without causing significant laryngeal edema or thermal activity.
Abramson
A L
AL
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Levy
A S
AS
Hirschfield
L S
LS
D000818:Animals; D017323:Dihematoporphyrin Ether; D004285:Dogs; D006046:Gold; D006415:Hematoporphyrins / Q000627:therapeutic use; D007830:Larynx / Q000293:injuries*; D053685:Laser Therapy; D010778:Photochemotherapy
D006415:Hematoporphyrins; D006046:Gold; D017323:Dihematoporphyrin Ether