[Significance of sex hormone binding globulin and free androgen index in the estimation of androgenic cases].
Hormone analyses for hirsute women suggested that free testosterone was most revealing in biological effects and sex-hormone-binding globulin (SHBG) was quantitatively persuative. Presented in this paper are the measurements of testosterone, androstendion, dehydroepiandrosterone-sulfate (DHAS), SHBG, androstandiol and free androgen index (FAI) in 51 women with hirsutism. 92% of the hirsute women with elevated androgen level showed decrease in SHBG values and increase in FAI. 17 females with hirsutism revealed abnormally high androstandiol values which were highly related to the values of total and free testosterone (r = 0.78, r = 0.80, respectively). It is suggested that in clinical practice SHBG and FAI should also be measured besides testosterone and DHAS.
Qiao
F Y
FY
Abteilung für Gynäkologie und Geburtshilfe, Tongji Hospital, Tongji Medizinische Universität, Wuhan.
Lauritzen
C
C
D000728:Androgens / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood
D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate
Die Bedeutung des sexualhormonbindenden Globulin und des freien Androgen-Index für die Beurteilung androgenetischer Krankheitsbilder.