Development of artificial placenta: oxygen metabolism of isolated goat fetuses with umbilical arteriovenous extracorporeal membrane oxygenation.
To assess the oxygen utilization of extrauterine goat fetuses with arteriovenous extracorporeal membrane oxygenation via umbilical vessels, oxygen delivery (OD) and oxygen consumption (OC) were investigated in 19 long-term incubations (incubation periods 58-236 h). The OCs did not change (6.4 +/- 1.3 ml/min/kg, mean +/- SD, n = 227) when the ODs were more than 10 ml/min/kg, but were significantly suppressed when the ODs were less than 10 ml/min/kg. It was suggested that the oxygen metabolism of extrauterine goat fetuses is equivalent to that of fetuses in utero.
Unno
N
N
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Kuwabara
Y
Y
Shinozuka
N
N
Akiba
K
K
Okai
T
T
Kozuma
S
S
Mizuno
M
M
D000818:Animals; D001187:Artificial Organs; D015199:Extracorporeal Membrane Oxygenation; D005333:Fetus / Q000378:metabolism*; D006041:Goats; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010920:Placenta; D014469:Umbilical Arteries; D014471:Umbilical Veins
D010100:Oxygen