title: Propofol anesthesia for major thoracic surgery.
abstract: One hundred patients undergoing elective thoracic surgery were anesthetized with propofol as a continuous intravenous infusion. In 60 patients, nitrous oxide was used for supplementation. The technique proved satisfactory, but induction of anesthesia was associated with significant decreases in blood pressure. The use of nitrous oxide markedly reduced the propofol requirements, and prolonged the time to the first spontaneous breath during recovery. The mean infusion rate of propofol was 7.2 +/- 2.72 mg/kg/h with air-oxygen, and 5.7 +/- 1.97 mg/kg/min with nitrous oxide-oxygen (P less than 0.01). This technique seems to be a satisfactory alternative for patients primarily requiring an intravenous anesthetic during thoracic surgery.
authors: Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast, Northern Ireland.
authors: K R
authors: KR
authors: Milligan
authors: D L
authors: DL
authors: Coppel
authors: J R
authors: JR
authors: Johnston
authors: J
authors: J
authors: Cosgrove
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006611:High-Frequency Jet Ventilation; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D013903:Thoracic Surgery; D013997:Time Factors
chemical_list: D005283:Fentanyl; D015742:Propofol