[Duration of immunity in children who received a primary complex of inoculations with ADT-M anatoxin and an assessment of postponed secondary revaccination against diphtheria and tetanus (the results of an epidemiologic trial)].
The prolonged observations of the immunological effectiveness of adsorbed diphtheria-tetanus toxoid with reduced antigen content in children who had received the primary course of immunization with this preparation showed that the preparation induced the development of prolonged and intensive immunity to both infections. In 2-3 years after the first booster immunization the protective level of diphtheria antitoxin was registered in 89.9% and that of tetanus antitoxin, in 99% of children. 6 years later the level of immunity remained practically unchanged: the titers of diphtheria antitoxin above the protection level were determined in 92% and those of tetanus antitoxin, in 97% of children. These data made it possible to increase intervals between booster immunizations to 6-7 years in children of this category. The results of the epidemiological trial made to find out the possibility of a change in the timing of the second booster immunization confirmed the expediency of postponing booster immunization from 6 and 11 years to 9 and 16 years of age.
Maksimova
N M
NM
Egor'kov
N A
NA
Kostiuchenko
G I
GI
Ogurtsova
S D
SD
Beschastnaia
N I
NI
Arzhevitina
K V
KV
D002648:Child; D004165:Diphtheria / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology; D006801:Humans; D007109:Immunity; D007115:Immunization Schedule; D007117:Immunization, Secondary; D009031:Moscow / Q000453:epidemiology; D012426:Russia / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D013742:Tetanus / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology; D013997:Time Factors; D014505:Urban Population / Q000706:statistics & numerical data
D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid
Dlitel'nost' sokhraneniia immuniteta u deteĭ, poluchivshikh pervichnyĭ kompleks privivok ADS-M-anatoksinom, i otsenka otsrochennoĭ vtoroĭ revaktsinatsii protiv difterii i stolbniaka (rezul'taty épidemiologicheskogo opyta).