Atrial natriuretic peptide in the renal response to an acute protein load.
A high protein meal acutely stimulates the glomerular filtration rate. In order to assess the possible role of atrial natriuretic peptide (ANP) as a mediator of this renal response, the ANP plasma concentrations were measured with a sensitive radioimmunoassay method before and after a large protein load (1.5 g/kg body weight given as a meat meal). Creatinine clearance increased significantly while fractional excretion of sodium remained constant. ANP plasma concentrations did not change after the protein load and the intra-individual variations of creatinine clearance were not correlated with the intra-individual changes in ANP plasma concentrations. It was concluded that ANP was probably not involved in the renal haemodynamic changes observed after a large protein load.
Moulin
B
B
Department of Nephrology, University Hospital, Rouen, France.
Dhib
M
M
Coquerel
A
A
Godin
M
M
Fillastre
J P
JP
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008460:Meat; D011863:Radioimmunoassay; D012079:Renal Circulation / Q000187:drug effects
D004044:Dietary Proteins; D009320:Atrial Natriuretic Factor