Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.
Emini
E A
EA
Merck, Sharp and Dohme Research Laboratories, West Point, PA 19486.
Schleif
W A
WA
Quintero
J C
JC
Conard
P G
PG
Eichberg
J W
JW
Vlasuk
G P
GP
Lehman
E D
ED
Polokoff
M A
MA
Schaeffer
T F
TF
Schultz
L D
LD
D000818:Animals; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis*; D015488:HIV Antigens / Q000276:immunology*; D016655:HIV Core Protein p24; D015700:HIV Envelope Protein gp41 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control; D007114:Immunization; D009500:Neutralization Tests; D002679:Pan troglodytes; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014758:Viral Core Proteins / Q000276:immunology
D015683:Gene Products, gag; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D015700:HIV Envelope Protein gp41; D011498:Protein Precursors; D011994:Recombinant Proteins; D014758:Viral Core Proteins; C059767:p55 gag precursor protein, Human immunodeficiency virus 1