[Changes of releases of beta-endorphin-like immunoreactive substances and noradrenaline in rabbit's preoptic area during acupuncture analgesia].
RIA and HPLC-ECD were used respectively to detect beta-endorphin-like immunoreactive substances (beta-EPIS), noradrenaline and 3-methoxy-4-hydroxyphenyloglycol (MHPG), a noradrenaline metabolite, in the perfusate from the rabbit's preoptic area before and after 10 min of electroacupuncture (EA). It was found that, the content of beta-EPIS in the perfusate increased during acupuncture analgesia, while those of noradrenaline and MHPG decreased. A negative correlation (r = -0.831; P less than 0.05) was shown between the changes of beta-EPIS and MHPG contents during acupuncture analgesia, indicating that beta-endorphin may be related to the inhibition of noradrenaline release during acupuncture analgesia.
Zhu
J M
JM
Department of Neurobiology, Shanghai Medical University.
He
X P
XP
Cao
X D
XD
D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D005260:Female; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011301:Preoptic Area / Q000378:metabolism*; D011817:Rabbits; D001615:beta-Endorphin / Q000378:metabolism*
D008734:Methoxyhydroxyphenylglycol; D001615:beta-Endorphin; D009638:Norepinephrine