Seasonal variations in binding of 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference.
Binding of paroxetine to blood platelet membranes was studied longitudinally in 20 healthy volunteers (11 men and 9 women) in order to determine seasonal and gender variations. Blood samples were obtained in September, December, March, and June, and repeated in September. A significant seasonal variation in the maximal number of binding sites (Bmax) was found. Men were found to have significantly lower (Bmax) values than women. Although the pattern of seasonal variation was not identical in men and women, no significant differences were detected. The affinity constant (KD) of paroxetine binding showed a significant seasonal variation. Men were found to have a significantly higher KD (lower affinity) than women. The pattern of seasonal variation was identical in men and women. These data support the evidence indicating a substantial seasonal effect on the serotonergic system, and show that in paroxetine binding studies, groups of subjects should be matched for season and gender.
Klompenhouwer
J L
JL
Department of Psychiatry, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
Fekkes
D
D
van Hulst
A M
AM
Moleman
P
P
Pepplinkhuizen
L
L
Mulder
P G
PG
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017374:Paroxetine; D010880:Piperidines / Q000493:pharmacokinetics*; D012016:Reference Values; D012621:Seasons; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; D012737:Sex Factors
D002352:Carrier Proteins; D010880:Piperidines; D012702:Serotonin Antagonists; D050486:Serotonin Plasma Membrane Transport Proteins; D017374:Paroxetine