title: Glycophospholipid membrane anchoring provides clues to the mechanism of protein sorting in polarized epithelial cells.
abstract: The sorting signals that guide proteins to apical and basolateral surfaces of epithelial cells have remained elusive. Current evidence suggests a hierarchy of sorting information with multiple sorting signals (apical and basolateral) present in different domains of a given plasma membrane protein. The observation that covalently attached glycosyl-phosphatidylinositol (GPI) acts as a 'dominant' apical targeting signal is compatible with the involvement of glycolipids in epithelial protein sorting.
authors: Cornell University Medical College, Department of Cell Biology and Anatomy, New York, NY 10021.
authors: M P
authors: MP
authors: Lisanti
authors: E
authors: E
authors: Rodriguez-Boulan
mesh_terms: D000818:Animals; D001692:Biological Transport; D004848:Epithelium / Q000378:metabolism; D006017:Glycolipids / Q000235:genetics / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D017261:Glycosylphosphatidylinositols; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D021382:Protein Sorting Signals / Q000235:genetics / Q000378:metabolism*
chemical_list: D006017:Glycolipids; D006023:Glycoproteins; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; D010716:Phosphatidylinositols; D021382:Protein Sorting Signals