Psoriasiform intradermal test reaction to ABPC in a patient with psoriasis and ABPC allergy.
We experienced a case of psoriasis with ABPC allergy which showed a psoriasiform intradermal test reaction to ABPC. A 22-year-old man with a history of psoriasis since the age of 17 was admitted to our department because he developed erythrodermic psoriasis after oral administration of ABPC. About 1 year later, he again developed erythroderma after administration of ABPC. Intradermal testing with 2% ABPC was performed. We found infiltrating erythema at day 2, followed by a gradually increasing psoriasiform reaction at 6 days on the site of ABPC skin test. We examined the infiltrating cells in the skin test reaction immunohistochemically. Most of the infiltrating cells in the dermis were activated helper/DTH-type T cells. Among the infiltrating cells in the epidermis, we observed more cytotoxic/suppressor-type T cells than helper/DTH-type T cells. A possible role of a DH reaction to ABPC in inducing the psoriatic lesion is discussed in relation to the pathomechanisms of psoriasis.
Saito
S
S
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Ikezawa
Z
Z
D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced / Q000473:pathology; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000473:pathology; D007428:Intradermal Tests; D008297:Male; D011565:Psoriasis / Q000139:chemically induced* / Q000473:pathology
D000667:Ampicillin