title: A structured psychiatric intervention for cancer patients. II. Changes over time in immunological measures.
abstract: We evaluated the immediate and long-term effects on immune function measures of a 6-week structure psychiatric group intervention for patients with malignant melanoma. Along with a reduction in levels of psychological distress and greater use of active coping methods, the following immune changes were seen at the 6-month assessment point in the intervention-group patients (n = 35) compared with controls (n = 26): significant increases in the percent of large granular lymphocytes (defined as CD57 with Leu-7) and natural killer (NK) cells (defined as CD16 with Leu-11 and CD56 with NKH1) along with indications of increase in NK cytotoxic activity; and a small decrease in the percent of CD4 (helper/inducer) T cells. At the 6-week follow-up point, the majority of these changes were not yet observable. The results indicate that a short-term psychiatric group intervention in patients with malignant melanoma with a good prognosis was associated with longer-term changes in affective state, coping, and the NK lymphoid cell system. Affective rather than coping measures showed some significant correlations with immune cell changes.
authors: Department of Psychiatry, UCLA School of Medicine.
authors: F I
authors: FI
authors: Fawzy
authors: M E
authors: ME
authors: Kemeny
authors: N W
authors: NW
authors: Fawzy
authors: R
authors: R
authors: Elashoff
authors: D
authors: D
authors: Morton
authors: N
authors: N
authors: Cousins
authors: J L
authors: JL
authors: Fahey
mesh_terms: D000223:Adaptation, Psychological; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008545:Melanoma / Q000276:immunology / Q000523:psychology / Q000601:surgery; D019964:Mood Disorders / Q000276:immunology / Q000523:psychology / Q000628:therapy*; D009369:Neoplasms / Q000276:immunology / Q000523:psychology* / Q000601:surgery; D011379:Prognosis; D011614:Psychotherapy, Brief; D011615:Psychotherapy, Group; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology