title: Suppression of T cell proliferation induced by concanavalin A in hemophilia patients.
abstract: Concanavalin A (Con-A)-induced suppression of T cell proliferation was studied in 48 patients with severe hemophilia. Two groups of patients were defined according to the proliferative response when increasing numbers of Con A-induced cells were added to a constant number of phytohemagglutinin (PHA)-stimulated autologous T cells: In group A (60%) and in normal controls, higher suppression was achieved when more Con A-induced cells were added; in Group B, increasing numbers of Con A-induced cells produced no suppression of stimulated PHA-triggered proliferation. This effect could be corrected in Group B by inducing suppression in the presence of inhibitors of the oxidative metabolism of arachidonic acid. No correlation was found between the suppression profile and HIV-1 or HBV serology. Clinical evolution, as judged by signs and symptoms of AIDS related complex tended to be better in Group B than in Group A patients. It is suggested that decreased Con A-induced suppression in Group B may represent part of a normal regulatory process that involves products of arachidonic acid oxidative metabolism.
authors: Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
authors: M C
authors: MC
authors: Sasiain
authors: S
authors: S
authors: de la Barrera
authors: B
authors: B
authors: Ruibal Ares
authors: G
authors: G
authors: Picchio
authors: G
authors: G
authors: Muchinik
authors: R
authors: R
authors: Pérez Bianco
authors: M
authors: M
authors: de Tezanos Pinto
authors: M M
authors: MM
authors: de Bracco
mesh_terms: D000293:Adolescent; D000328:Adult; D003208:Concanavalin A; D006679:HIV Seropositivity / Q000276:immunology; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D003208:Concanavalin A