title: Fibrinolysis in patients with diabetic nephropathy determined by plasmin-alpha 2 plasmin inhibitor complexes in plasma.
abstract: Activation of fibrinolysis in patients with diabetic nephropathy was determined by the plasma levels of plasmin-alpha 2 plasmin inhibitor complexes (alpha 2PIC) using a one-step sandwich enzyme immunoassay (EIA). Plasma levels of alpha 2PIC in diabetic patients with persistent proteinuria were significantly higher than those in diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Plasma levels of alpha 2PIC in diabetic patients with intermittent proteinuria were also significantly higher than those of diabetic patients without proteinuria, patients with chronic glomerulonephritis, and healthy adults. Diabetic patients have been suggested to have a hypercoagulable state. The findings obtained from this study indicated that activation of fibrinolysis might counteract the hypercoagulable state in patients with diabetic nephropathy.
authors: Department of Internal Medicine, School of Medicine, Tokai University, Isehara City, Japan.
authors: M
authors: M
authors: Yagame
authors: K
authors: K
authors: Eguchi
authors: D
authors: D
authors: Suzuki
authors: H
authors: H
authors: Machimura
authors: H
authors: H
authors: Takeda
authors: W
authors: W
authors: Inoue
authors: K
authors: K
authors: Tanaka
authors: H
authors: H
authors: Kaneshige
authors: Y
authors: Y
authors: Nomoto
authors: H
authors: H
authors: Sakai
mesh_terms: D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood*; D005341:Fibrinolysin / Q000097:blood*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood; D000979:alpha-2-Antiplasmin
chemical_list: D000933:Antifibrinolytic Agents; D000979:alpha-2-Antiplasmin; C037742:plasmin-plasmin inhibitor complex; D005341:Fibrinolysin