The enterochromaffin cells in the mouse gastrointestinal tract after streptozotocin treatment.
Effects of 5 weeks streptozotocin treatment on the mouse gastrointestinal tract were studied with special emphasis on enterochromaffin (EC) cells. In the streptozotocin-treated animals the frequency of EC cells was reduced in the antral area and in the small intestine, but increased in the colon. The length of the intestinal tract and the mucosal thickness were increased in these animals. Possible mechanisms underlying these abnormalities of the EC cell system are discussed.
Portela-Gomes
G M
GM
Department of Medicine II, Lisbon University, Portugal.
Wilander
E
E
Grimelius
L
L
Bergström
R
R
Ruhn
G
G
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002838:Chromaffin System / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004064:Digestive System / Q000187:drug effects* / Q000473:pathology; D004759:Enterochromaffin Cells / Q000187:drug effects* / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects; D006029:Glycosuria / Q000139:chemically induced; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013311:Streptozocin / Q000633:toxicity*
D001786:Blood Glucose; D013311:Streptozocin