title: Effect of atrial natriuretic peptide on renin release in rat isolated glomeruli.
abstract: Effects of atrial natriuretic peptide (ANP) on renin release in isolated rat glomeruli were investigated. ANP suppressed renin release by 25% at 5 x 10(-8) M when glomeruli were incubated in a medium containing 1.26 mM calcium (p = 0.0019). When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively). These results indicate that ANP suppresses renin release in a dose dependent manner, probably through a calcium independent process.
authors: Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
authors: S
authors: S
authors: Kageyama
authors: J
authors: J
authors: Brown
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
chemical_list: D004533:Egtazic Acid; D009320:Atrial Natriuretic Factor; D012083:Renin; D002118:Calcium