Biochemical evidence for mediatory role of 5-hydroxytryptamine in the uterotonic action of prostaglandin F2oc.
5-Hydroxytryptamine (5-HT) is reported to be involved in endogenous prostaglandin (PG)--modulated as well as exogenous PG-induced pharmacological activities including oxytocic effect of PGE1 PGE2oc Biochemical parameters were undertaken for further studies into the possible role of 5-HT in the uterotonic effect of PGF2oc on isolated oestronised rat uterus. The results substantiate the involvement of endogenous 5-HT in the uterotonic effect of PGF2oc.
Bhattacharyya
D
D
Department of Pharmacology, University College of Medicine, Calcutta University, India.
Bhattacharjee
S
S
Nag
B N
BN
Maity
C R
CR
Bandyopadhyay
S K
SK
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014191:Tranylcypromine / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D012701:Serotonin; D014191:Tranylcypromine; D015237:Dinoprost; D010134:Fenclonine; D007213:Indomethacin