title: Musculoskeletal neoplasms after intraarterial chemotherapy: correlation of MR images with pathologic specimens.
abstract: The most accurate prognostic indicator in patients with musculoskeletal sarcomas is the percentage of tumor necrosis after intraarterial chemotherapy. Magnetic resonance (MR) imaging was evaluated to determine its ability to indicate the percentage of necrosis in musculoskeletal neoplasms after treatment. Fourteen patients with musculoskeletal neoplasms underwent treatment protocols including intraarterial chemotherapy (n = 14), radiation therapy (n = 6), and systemic chemotherapy (n = 14). All patients underwent MR imaging before and after treatment, and all underwent either limb salvage surgery (n = 8) or amputation (n = 6) within 1 week of the last MR examination. Standard unehanced spin-echo T1-, spin-density-, and T2-weighted MR sequences were used. The MR images were compared with the pathologic specimens. On T2-weighted images, the signal intensities of viable tumor, tumor necrosis, edema, hemorrhage, and necrosis overlapped. With the unenhanced spin-echo technique, MR imaging cannot be used to predict the percentage of tumor necrosis in musculoskeletal neoplasms after intraarterial chemotherapy.
authors: Department of Radiology, H. Lee Moffit Cancer Center and Research Institute, Tampa, Fla.
authors: R B
authors: RB
authors: Sanchez
authors: S F
authors: SF
authors: Quinn
authors: A
authors: A
authors: Walling
authors: J
authors: J
authors: Estrada
authors: H
authors: H
authors: Greenberg
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D001842:Bone and Bones / Q000473:pathology; D003131:Combined Modality Therapy; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D009132:Muscles / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents