[Blood levels of opioid peptides and alpha interferon under the action of dipyridamole].
The levels of met-enkephalin (ME), beta-endorphin (BE), and alpha-interferon (a-IFN) have been determined in the human blood 1 day after dipyridamole administration. Dipyridamole led to an increase in serum a-IFN concentration up to 3 times, and to simultaneous rise of the lymphocytes ability to produce a-IFN. The content of BE did not depend on dipyridamole treatment, but ME level achieved 110 +/- 4.8 pg/ml (compare to 79.5 +/- 7.6 pg/ml in control). Positive interrelation has been found out between individual ME concentrations and lymphocyte abilities to a-IFN production with the coefficient of correlation equal to 0.69. The effect of dipyridamole on ME level is suggested to develop via a-IFN interaction with the opioid systems.
Balashov
A M
AM
Surkina
I D
ID
Gotovtseva
E P
EP
Petrichenko
O B
OB
Panchenko
L F
LF
D000328:Adult; D000367:Age Factors; D000368:Aged; D004176:Dipyridamole / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000097:blood*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*
D007370:Interferon Type I; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D004176:Dipyridamole
Soderzhanie opioidnykh peptidov i al'fa-interferona v krovi pri deĭstvii dipiridamola.