Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter.
EIa-dependent transactivation of the adenovirus EIIa early (EIIaE) promoter is correlated with the activation of the cellular transcription factor E2F. In this study we identified a cellular protein, C alpha, that is distinct from E2F and that binds two sites in the EIIaE promoter, one of which overlaps with the proximal E2F binding site of the EIIaE promoter. The possible involvement of C alpha in the EIa responsiveness of this promoter is discussed.
Jansen-Durr
P
P
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Faculté de Médecine, Strasbourg, France.
Wintzerith
M
M
Reimund
B
B
Hauss
C
C
Kédinger
C
C
D000256:Adenoviridae / Q000235:genetics*; D017456:Adenovirus Early Proteins; D001483:Base Sequence; D001667:Binding, Competitive; D015342:DNA Probes; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000302:isolation & purification / Q000378:metabolism*; D015533:Transcriptional Activation
D017456:Adenovirus Early Proteins; D015342:DNA Probes; D009856:Oncogene Proteins, Viral; D014157:Transcription Factors