Pharmacological modulation by cetirizine and loratadine of antigen and histamine-induced skin weals and flares, and late accumulation of eosinophils.
In a double-blind, randomized, crossover study performed in atopic subjects, the inhibitory effects of single doses of 10 mg cetirizine and 10 mg loratadine on histamine- and grass pollen-induced skin reactions were evaluated 4 h after drug intake. Cetirizine significantly inhibited histamine- and antigen-induced skin reactions, as well as the accumulation of eosinophils measured 24 h after antigen challenge. Loratadine, however, did not significantly inhibit the skin reactions induced by histamine and grass pollen, nor eosinophil accumulation.
Fadel
R
R
Immuno-allergic Unit, Pasteur Institute, Paris, France.
Herpin-Richard
N
N
Dufresne
F
F
Rihoux
J P
JP
D000328:Adult; D017332:Cetirizine; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003533:Cyproheptadine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017336:Loratadine; D008297:Male; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D014581:Urticaria / Q000188:drug therapy / Q000517:prevention & control*
D003533:Cyproheptadine; D006919:Hydroxyzine; D017336:Loratadine; D017332:Cetirizine