Enhanced affective aggression in genetically bred hypercholinergic rats.
Affective aggression was studied in pairs of Flinders Sensitive Line hypercholinergic rats (FSL) and Flinders Resistant Line (FRL) rats in shock-induced and apomorphine-induced fighting tests. FSL rats were significantly more aggressive in both tests. They had higher pain threshold, assessed by the jump-flinch method, than FRL rats. It is concluded that genetically developed cholinergic system supersensitivity has resulted in enhanced responsiveness to stimuli eliciting affective aggression.
Pucilowski
O
O
Skipper Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill.
Eichelman
B
B
Overstreet
D H
DH
Rezvani
A H
AH
Janowsky
D S
DS
D000109:Acetylcholine / Q000502:physiology; D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003863:Depression / Q000503:physiopathology / Q000523:psychology; D004597:Electroshock; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011930:Reaction Time; D012684:Sensory Thresholds / Q000502:physiology
D001058:Apomorphine; D000109:Acetylcholine