[The mechanism of natural resistance in the rat to Entamoeba histolytica].
The data presented in this paper may be summarized as follows: 1) intraportal injection of a virulent strain (HM-1) of Entamoeba histolytica in Wistar rats, of both sexes, gives way to non-progressive microscopic changes, characterized by a rapid leukocytic reaction surrounding the amebas, disappearance of the parasites within 5 hours, and total lack of hepatic damage; 2) leucopenia only modifies the previous description by the fact that there are no leucocytes around the amebas, although these disappear in the same time, showing, at this moment, an early and prominent vacuolar degeneration; 3) hypocomplementaemia shows the same results as leucopenia; 4) fragments and extracts from various tissues from the rat and hamster show variable degrees of interference with the viability of axenic amebas of Entamoeba histolytica conserved in culture; only a minimal part of the interference to be due to the activity of the complement which is present in the tissue extracts.
Pérez-Tamayo
R
R
Sub-División de Medicina Esperimental, Facultad de Medicina, U.N.A.M. México, D.F.
Becker
I
I
Martínez
R D
RD
Olivos
A
A
Montfort
I
I
Pérez-Montfort
R
R
D000818:Animals; D003165:Complement System Proteins / Q000172:deficiency / Q000502:physiology*; D006224:Cricetinae; D004748:Entamoeba histolytica / Q000302:isolation & purification / Q000472:pathogenicity*; D004749:Entamoebiasis / Q000150:complications / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate; D007668:Kidney / Q000469:parasitology; D007970:Leukopenia / Q000139:chemically induced / Q000150:complications; D008099:Liver / Q000469:parasitology; D008297:Male; D008466:Mechlorethamine / Q000633:toxicity; D008647:Mesocricetus / Q000469:parasitology; D009504:Neutrophils / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains / Q000469:parasitology*; D013045:Species Specificity; D013737:Testis / Q000469:parasitology; D014774:Virulence
D008466:Mechlorethamine; D003165:Complement System Proteins
Estudios sobre el mecanismo de la resistencia natural de la rata a Entamoeba histolytica.