Pulmonary blastoma with neuroendocrine differentiation in cell morules resembling neuroepithelial bodies.
Pulmonary blastoma is an infrequent malignant neoplasm, so called because of its resemblance to fetal lung. The original description outlined the components as variable mixtures of epithelial and stromal elements. More recently, a variant displaying almost exclusively epithelial differentiation has been described. We report our findings in a case of pulmonary blastoma with predominance of epithelial cells, forming tubular structures and large morules. The architectural arrangement of the morules was remarkably similar to normal bronchial neuroepithelial bodies. Moreover, their immunohistochemical profiles were also very similar, including the expression of cytokeratins, chromogranin, neuron-specific enolase, synaptophysin, gastrin, calcitonin, bombesin, somatostatin and serotonin.
Chejfec
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Department of Pathology, Hines VA Hospital-Loyola University School of Medicine, IL 60141.
Cosnow
I
I
Gould
N S
NS
Husain
A N
AN
Gould
V E
VE
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002864:Chromogranins / Q000032:analysis; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008565:Membrane Proteins / Q000032:analysis; D009490:Neurosecretory Systems / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin
D002864:Chromogranins; D008565:Membrane Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase