Variation among the dispersed (GATA)n sequences in Drosophila melanogaster.
Five nonallelic copies of the dispersed (GATA)n repeated sequence of Drosophila melanogaster (referred to as GATA elements) have been sequenced and analysed. The GATA elements range in size from 111 to 444 bp, consisting predominantly of tandemly repeated GATAs, interspersed with variants of the subunit. The types and distributions of these variants are consistent with the hypothesis that they have arisen by a random accumulation of point mutations (substitutions, deletions, and insertions) in pure (GATA)n sequences. Duplications or deletions of the GATA subunit, and of GATA variants, have also probably occurred, as a result of either unequal crossing-over or slipped-strand mispairing. Evidence for duplication (deletion) has been obtained from a comparison of two allelic GATA elements isolated from different populations. GATA elements, in common with other dispersed, simple repeats, are probably highly variable in length.
Simpson
P R
PR
Department of Evolutionary and Population Biology, Research School of Biological Sciences, Australian National University, Canberra City, Australian Capital Territory.
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D015698:Genomic Library; D008969:Molecular Sequence Data; D009154:Mutation; D012091:Repetitive Sequences, Nucleic Acid