[Comparison of sufentanil and fentanyl anesthesia for coronary artery bypass grafting--changes in stress hormones].
We compared the changes in hemodynamics and stress hormones in 30 patients who received for CABG operation either sufentanil-oxygen or fentanyl-oxygen anesthesia. The mean doses of fentanyl and sufentanil for intubation were 1.66 +/- 0.69 mg and 0.35 +/- 0.14 mg respectively and mean total doses were 6.91 +/- 1.14 mg and 1.68 +/- 0.38 mg, or 21.4 micrograms.kg-1.hr-1 and 4.5 micrograms.kg-1.hr-1 respectively. SAP decreased significantly immediately before intubation in both groups. Immediately after intubation, a significant intergroup difference (P less than 0.05) was noted. The changes in DAP and MAP were almost similar to those of SAP. This study demonstrates that sufentanil-oxygen anesthesia gave more stable hemodynamic parameters before and after intubation. Especially no significant changes in heart rate occurred immediately after intubation and with CABG operation, thus preventing the increase in rate pressure product during procedure. Sufentanil anesthesia did attenuate more effectively the stress hormones release than high dose fentanyl anesthesia, but neither sufentanil nor fentanyl anesthesia could prevent the increases in these hormones postoperatively.
Ikeda
T
T
Department of Anesthesiology, Hachiohji Medical Center.
Ikeda
K
K
Isshiki
A
A
Herregods
L
L
Rolly
G
G
Miyake
T
T
D000368:Aged; D000768:Anesthesia, General; D001026:Coronary Artery Bypass; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D013312:Stress, Physiological / Q000097:blood*; D017409:Sufentanil
D006728:Hormones; D017409:Sufentanil; D010100:Oxygen; D005283:Fentanyl