Phototoxic properties of perfumes containing bergamot oil on human skin: photoprotective effect of UVA and UVB sunscreens.
As part of an international cooperative study of the photophysical, photomutagenic and photocarcinogenic properties of bergamot oil and the effect of UVA and UVB sunscreens, the phototoxic properties of model perfumes containing 5, 15 and 50 ppm 5-methoxypsoralen (5-MOP) in bergamot oil with and without a sunscreen have been investigated on human skin. It has been confirmed that the photosensitivity of human skin is maximal 2 h after perfume application. Interestingly the addition of a UVA sunscreen is more efficient for decreasing the phototoxic properties of bergamot oil than is a UVB sunscreen. The addition of sunscreens in a model perfume containing 50 ppm 5-MOP in bergamot oil can reduce the phototoxic properties of this perfume to a toxicity equivalent to that produced by the application of a model perfume containing 15 ppm 5-MOP without sunscreens. However, despite their promising protective effect in vitro, UVB and UVA sunscreens at low concentration (0.5%-1%) in perfumes cannot suppress the phototoxicity of bergamot oil on human skin.
Dubertret
L
L
Laboratoire de Dermatologie, INSERUM U.312, Hôpital Henri Mondor, Créteil, France.
Serraf-Tircazes
D
D
Jeanmougin
M
M
Morlière
P
P
Averbeck
D
D
Young
A R
AR
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010476:Perfume / Q000009:adverse effects*; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000209:etiology* / Q000517:prevention & control; D010938:Plant Oils / Q000009:adverse effects* / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects
D010476:Perfume; D010938:Plant Oils; D011838:Radiation-Sensitizing Agents; D013473:Sunscreening Agents; C068336:bergamot oil