title: A convenient synthesis of trans-3'-hydroxycotinine, a major nicotine metabolite found in the urine of tobacco users.
abstract: trans-3'-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3'-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.
authors: Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595.
authors: D
authors: D
authors: Desai
authors: S
authors: S
authors: Amin
mesh_terms: D003367:Cotinine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: C001381:hydroxycotinine; D003367:Cotinine