[Leishmaniasis: effect of factors present in serum].
An important role in the interaction between protozoan parasite Leishmania and host is determined by serum factors. The activation of complement can have resistance-promoting effects (due to the lysis of parasite) or disease-promoting effect (due to the opsonization of Leishmania). Also lymphokines can determine resolution or progression of the infection. Particularly, gamma-interferon "in vitro" increases the killing of the parasite and "in vivo" cures cutaneous leishmaniasis.
Savoia
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D
Isituto di Microbiologia, Università di Torino.
Cestaro
A
A
Biglino
S
S
D000818:Animals; D003167:Complement Activation; D006790:Host-Parasite Interactions; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007371:Interferon-gamma / Q000502:physiology / Q000627:therapeutic use; D007891:Leishmania / Q000254:growth & development / Q000276:immunology; D007896:Leishmaniasis / Q000097:blood* / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000628:therapy; D008222:Lymphokines / Q000502:physiology* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins; D016176:T-Lymphocyte Subsets / Q000276:immunology
D007155:Immunologic Factors; D008222:Lymphokines; D011994:Recombinant Proteins; D007371:Interferon-gamma
Leishmanie: effetto di fattori presenti nel siero.