[The correlation between the activity of tissue plasminogen activator (TPA), levels of tissue plasminogen activator inhibitor (PAI-1) antigen and serum lipids in healthy subjects].
It is well known that abnormality of the coagulation-fibrinolytic system and serum lipids plays an important role in the development of thrombi and atherosclerotic disease. In the present study, the correlation between the activity of tissue plasminogen activator (TPA), the levels of tissue plasminogen activator inhibitor (PAI-1) and serum lipids (TC, TG, beta-Lp, HDLC, LDLC and apolipoproteins) were studied in 102 healthy subjects. The activity of TPA showed negative correlation with the obesity rate (r = 0.21, p less than 0.05) but levels of PAI-1 antigen showed a positive correlation with the obesity rate (r = 0.182, p less than 0.1). The activity of TPA showed no correlation with serum lipids including apolipoproteins, while the levels of PAI-1 antigen showed a positive correlation between TG and beta-Lp (r = 0.292, p less than 0.01, r = 0.211, p less than 0.05). The levels of PAI-1 antigen showed a negative correlation with HDLC (r = -0.286, p less than 0.01). These results indicate that TPA and PAI-1 play an important role in the development of thrombotic disease and atherosclerotic disease.
Kobayashi
Y
Y
Second Department of Internal Medicine, Nippon Medical School.
Fukuo
Y
Y
Shibuya
T
T
Terashi
A
A
D000328:Adult; D000368:Aged; D000941:Antigens / Q000378:metabolism*; D001161:Arteriosclerosis / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood* / Q000276:immunology; D012016:Reference Values; D013927:Thrombosis / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood*
D000941:Antigens; D008055:Lipids; D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator