Coffee, caffeine and hemostasis: results from two randomized studies.
The influence of coffee and caffeine consumption on hemostatic factors was studied in 2 randomized trials. Both studies were conducted in young, healthy adults. In the first study, 107 participants were randomly allocated to one or 3 intervention groups, drinking filtered coffee, boiled coffee or no coffee at all, respectively, for a period of 9 weeks. In the second study, 69 subjects received either 4-6 tablets containing 75 mg caffeine or the same amount of placebo tablets, while using decaffeinated coffee. In this double-blind study caffeine intake from any other source was not allowed. Blood samples for hemostatic factors were obtained at baseline and after 9 weeks of intervention. The findings indicate no effect of coffee consumption on fibrinogen, clotting factor VII activity, factor VIII antigen, protein C and protein S and also no effect of caffeine consumption on fibrinogen and factor VII activity.
Bak
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Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
van Vliet
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HH
Grobbee
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D000328:Adult; D002110:Caffeine / Q000009:adverse effects*; D003069:Coffee / Q000009:adverse effects*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D009426:Netherlands; D011486:Protein C / Q000378:metabolism; D017293:Protein S
D003069:Coffee; D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D002110:Caffeine; D005167:Factor VII; D005169:Factor VIII; D005340:Fibrinogen