ANP concentrations of atria, plasma and brain in Dahl S (DS) and Dahl R (DR) rats.
In order to investigate the possible involvement of ANP in the salt dependent hypertension of the DS rats the concentrations of immunoreactive atrial natriuretic peptides (ANP-IR) in atria, plasma and brain of salt loaded and control fed DS and DR rats were determined. On a low salt diet the ANP-IR concentrations in atria, hypothalamus and basal ganglia of DS rats were higher versus DR rats. Salt loading results in a decrease of ANP-IR in left DS atria and an increase in plasma and brain stem of DS rat versus control and DR rat. The data are compared with other studies about ANP performed in Dahl rats, SHR and WKY rats. The possible reasons for the found distribution of ANP-IR are discussed.
John
A E
AE
Department of Analytical Therapy Research, Bayer AG, Wuppertal, West-Germany.
Morich
F J
FJ
D000818:Animals; D000911:Antibodies, Monoclonal; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal; D009320:Atrial Natriuretic Factor