Topical ketoconazole for infantile seborrhoeic dermatitis.
In an open study, 19 infants with a bipolar seborrhoeic rash were treated with ketoconazole 2% in cream once a day and evaluated over 10 days of treatment. At day 10, 78.9% of patients were almost cleared. Percutaneous absorption peaked 1-3 h after topical treatment, and was minimal. No plasma ketoconazole accumulation over the 10-day treatment was detected. Treatment failures corresponded to histologically psoriasiform eruptions and probable atopic dermatitis.
Taieb
A
A
Service de Dermatologie Pédiatrique, Hôpital des Enfants, Bordeaux, France.
Legrain
V
V
Palmier
C
C
Lejean
S
S
Six
M
M
Maleville
J
J
D000279:Administration, Cutaneous; D012628:Dermatitis, Seborrheic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007654:Ketoconazole / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male
D007654:Ketoconazole