A placebo controlled trial of bismuth salicylate in Helicobacter pylori associated gastritis.
In a placebo controlled prospective clinical trial of bismuth salicylate in helicobacter pylori associated gastritis, 52 adult patients were randomly allocated to treatment with bismuth salicylate or placebo. Helicobacter pylori were totally cleared in 77% patients in bismuth group but none in placebo group (P less than 0.001). Resolution of gastritis (P less than 0.001) and improvement of symptoms (P less than 0.01) were significantly better in patients where H. pylori infection cleared as compared to patients where the infection persisted.
Kazi
J I
JI
Department of Pathology, Pakistan Medical Research Council, Karachi.
Jafarey
N A
NA
Alam
S M
SM
Zuberi
S J
SJ
Kazi
A M
AM
Qureshi
H
H
Ahmed
W
W
D000293:Adolescent; D000328:Adult; D001729:Bismuth / Q000627:therapeutic use*; D005260:Female; D005756:Gastritis / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D012459:Salicylates / Q000627:therapeutic use*; D020156:Salicylic Acid
D010919:Placebos; D012459:Salicylates; D020156:Salicylic Acid; D001729:Bismuth