[Experimental study relating to the anti-cancer effect of doxifluridine].
We investigated the anti-cancer effect of Doxifluridine (5'-deoxy-5-fluorouridine: 5'-DFUR) on an experimentally prepared tumor bearing mouse.


METHODS
A 20-methylcholanthrene induced squamous cell cancer was prepared on the skin of ddN female mouse and 5'-DFUR was administered orally by catheter (90 mg/kg, 150 mg/kg, 210 mg/kg and physiological saline 0.5 ml/body). The each group consisted of 10 mice. Oral medications were performed once a day for one week (6 days continuous duration) and these medications were continued during a total period of four weeks. Once a week, the general condition of the animals was checked and at the same time, the size (length x width) of the tumor was measured, and the anti-cancer effect was determined.


RESULTS
It was noted between the control and 5'-DFUR medication group that there was a marked effectiveness on the rate of decrease in size and disappear of the squamous cell cancer according to the medication of 5'-DFUR. It regarded to the amount of 5'-DFUR, that there was a significant difference in the anti-cancer effect between 90 mg/kg and 210 mg/kg groups and between 150 mg/kg or 210 mg/kg and control groups. However, the difference could not be observed between 90 mg/kg and 150 mg/kg groups and between 150 mg/kg and 210 mg/kg groups.
Zhao
L
L
Department of Oral Surgery, Nagoya University School of Medicine.
Kaneda
T
T
Tohnai
I
I
Shinoda
T
T
Kasuya
Y
Y
Matsuyama
M
M
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage / Q000627:therapeutic use*; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D000970:Antineoplastic Agents; D005467:Floxuridine; D008748:Methylcholanthrene; C025034:doxifluridine