The actions of human atrial natriuretic factor on hepatic arterial and portal vascular beds of the anaesthetized dog.
1. The vascular actions of atrial natriuretic factor (ANF) have been assessed with other vasoactive agents on the hepatic arterial and portal vascular beds of the anaesthetized dog. 2. Intra-arterial bolus injections of ANF (0.1-50 nmol) caused graded increases in hepatic arterial blood flow representing a vasodilatation of relatively short duration. Vasoconstriction was never observed. 3. The maximum increase in hepatic arterial blood was the same for ANF and isoprenaline (Iso) i.e. approximately 60-70% increase over control flow. 4. On a molar basis, ANF was less potent than Iso although over the higher dose range (10(-9)-10(-7) mol) its vasodilator activity exceeded that of the endogenous vasodilator adrenaline. 5. Intraportal bolus injections (1.0-50 nmol) of ANF did not alter portal inflow resistance since no changes in portal inflow pressure occurred when the portal circuit was perfused at constant inflow volume. 6. This differential action of ANF on the hepatic arterial and portal vascular beds may provide a change in total liver blood flow in favour of the arterial component. 7. ANF, by altering hepatic haemodynamics to favour formation of trans-sinusoidal fluid exchange, may provide a temporary expansion of the extravascular fluid reservoir to buffer any increased venous pressure. However, chronically elevated plasma levels of ANF would encourage the formation of ascitic fluid.
Withrington
P G
PG
Department of Pharmacology, Medical College of St. Bartholomew's Hospital, Charterhouse Square, London.
Dhume
V G
VG
Croxton
R
R
Gerbes
A L
AL
D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006499:Hepatic Artery / Q000187:drug effects; D007269:Injections, Intra-Arterial; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology; D008102:Liver Circulation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D011169:Portal Vein / Q000187:drug effects
C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor; D007545:Isoproterenol; D009638:Norepinephrine