Plasma dehydroepiandrosterone-to-cortisol ratios as an indicator of stress in gynecologic patients.
To evaluate the usefulness of the plasma dehydroepiandrosterone (DHEA)-to-cortisol ratio (D/C) and the plasma aldosterone-to-plasma renin activity ratio (ALDO/PRA) as indicators of stress, we first monitored changes in these ratios associated with surgery in 13 patients who were healthy except for their localized gynecologic diseases. D/C and ALDO/PRA ratios were reduced by 37 and 42%, respectively, 4-5 days postsurgery compared to those 3-4 days before surgery (P less than 0.05 and P less than 0.01, respectively) and returned to preoperative levels 11-13 days after surgery. In contrast, individual hormone levels showed no significant changes associated with surgery. Having documented that these ratios may serve as indicators of stress, we then sequentially measured D/C ratios in patients with gynecologic malignancy subjected to cytotoxic chemotherapy or radiation therapy and in patients in the terminal stage. Although such therapies did not affect D/C ratios to a measurable extent, patients in the terminal stage gave consistently low D/C ratios in spite of normal vital signs (a D/C ratio below 6 was deemed low). Such low ratios occurred only sporadically in other patients and, again, individual values for DHEA and cortisol showed no consistent pattern. We believe that use of D/C ratios as an indicator of stress warrants further investigation.
Ozasa
H
H
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
Kita
M
M
Inoue
T
T
Mori
T
T
D000450:Aldosterone / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications*; D005833:Genital Neoplasms, Female / Q000150:complications / Q000473:pathology / Q000628:therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D009367:Neoplasm Staging; D012083:Renin / Q000097:blood; D013312:Stress, Physiological / Q000097:blood* / Q000150:complications
D003687:Dehydroepiandrosterone; D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone