Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation.
The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.
Holland
V A
VA
Rockwell-McKelvey Pulmonary Immunology Laboratory, Baylor College of Medicine, Houston, Texas.
Cagle
P T
PT
Windsor
N T
NT
Noon
G P
GP
Greenberg
S D
SD
Lawrence
E C
EC
D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D005260:Female; D006084:Graft Rejection; D016041:Heart-Lung Transplantation / Q000009:adverse effects*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D016131:Lymphocyte Subsets / Q000276:immunology*; D011183:Postoperative Complications
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D000949:Histocompatibility Antigens Class II