title: Kit preparation of technetium-99m-mercaptoacetyltriglycine: analysis, biodistribution and comparison with technetium-99m-DTPA in patients with impaired renal function.
abstract: Technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3) was prepared by a frozen solution method, enabling the preparation of kits yielding a product substantially free of lipophilic impurities (96% 99mTc-MAG3). However, biliary activity was not completely eliminated as HPLC-purified 99mTc-MAG3 was also excreted by that route. Sequential 99mTc-DTPA and 99mTc-MAG3 renal scans were performed in 15 patients with renal dysfunction, including renal transplant recipients. In all cases, the 99mTc-MAG3 kit preparation provided superior images to 99mTc-DTPA at all levels of renal function due to a higher target-to-background ratio and a plasma clearance twice as fast as 99mTc-DTPA. Interpretation of delayed 99mTc-MAG3 images, however, was complicated by biliary excretion which will limit quantitative estimates of renal clearance. A 99mTc-MAG3 kit is likely to be of value in renal transplant assessment and in cases of significant renal impairment but would not appear to offer major advantages over 99mTc-DTPA in routine renal imaging.
authors: Department of Nuclear Medicine, Royal Adelaide Hospital, South Australia.
authors: K M
authors: KM
authors: Bannister
authors: S
authors: S
authors: Penglis
authors: J C
authors: JC
authors: Bellen
authors: R J
authors: RJ
authors: Baker
authors: B E
authors: BE
authors: Chatterton
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate; D014018:Tissue Distribution
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate