[Origin of mature granulocytes in the active phase and in remission in various types of acute leukemias].
The problem of provenance of the mature granulocytes in acute myeloblastic leukemia (AML) and in acute lymphoblastic leukemia in their active phase and in remission is still completely unresolved. Mature granulocytes could possibly arise in acute phase of AML from the remaining normal möelopoietic or granulopoietic stem cell or from the very leukemic clone of stem cell which still display, at least partially, the ability to sustain maturation to normal granulocyte level. In ALL, mature granulocyte probably arise from normal granulocyte precursors. In remitted AML, according to opinions of a majority of authors, mature neutrophils descend from normal stem cells. Following the study of 19 patients with AML and 19 patients with ALL, by utilizing the morphological, cytochemical and cytoenzymic properties of granulocytes et the light and electronomicroscopic level the authors have concluded: (1) in comparison with normal granulocytes, granulocytes show in the active AML, hypogranularity as well as a decrease in the activity of all studied enzymes (myeloperoxidase, alkaline and acidic phosphatase and the esterases). (2) In ALL, mature granulocytes do not feature any particular differences in the above pattern as compared with normal granulocytes. (3) In AML remission, the difference between the mature granulocytes and the granulocytes in the active disease is rather slight as compared with the morphological, cytochemical an cytonzymic characteristics. The authors conclude that in a number of patients with AML and in the remitted patients mature granulocytes could possibly originate from the leukemic stem cells which acquired the ability to respond to normal CSF by manner of the gross destruction of the leukemic tumour mass.(ABSTRACT TRUNCATED AT 250 WORDS)
Trpinac
D
D
Janković
G
G
Stefanović
S
S
D000208:Acute Disease; D006098:Granulocytes / Q000201:enzymology / Q000648:ultrastructure*; D006651:Histocytochemistry; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000473:pathology*; D012074:Remission Induction
Poreklo zrelih granulocita u aktivnoj fazi i remisiji raznih oblika akutnih leukemija.