[Anticalcium preparations that prevent the neurodegenerative action of quinolinic acid].
The protective effect of anticalcium drugs on the development of quinolinate destruction in the dorsal hippocampus and nuclei of the lateral septum was studied on rats with the cannulae chronically implanted into the lateral ventricles. It was found that single doses of kynurenic acid (50 micrograms), taurine (300 micrograms) and verapamil (25 micrograms) prevented the destructive effect of quinolinic acid (30 micrograms) during central administration whereas cinnarizine (25 micrograms) and corinfar (15 micrograms) were active in oral 8-day-long administration.
Kozlovskiĭ
V L
VL
Geĭnisman
N V
NV
Prakh'e
I V
IV
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007276:Injections, Intraventricular; D009410:Nerve Degeneration / Q000187:drug effects*; D011725:Pyridines / Q000037:antagonists & inhibitors*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors*; D051381:Rats; D012686:Septal Nuclei / Q000187:drug effects / Q000473:pathology
D002121:Calcium Channel Blockers; D011725:Pyridines; D011805:Quinolinic Acids; D017378:Quinolinic Acid
Antikal'tsievye preparaty, preduprezhdaiushchie neĭrodegenerativnoe deĭstvie khinolinovoĭ kisloty.