[Effects of aescine and aesculine on kidney excretion of water and electrolytes in rats].
Effects of aescine and aesculine, active principles of the horsechestnut, on urinary excretion of water and electrolytes, were investigated in saline loaded rats. Results indicate that aesculin shows a moderated diuretic activity, increasing significantly the renal loss of sodium, chloride and potassium. Nevertheless, only the highest dose of aescine caused the same degree of minease in saluresis with aesculin, where a doses-response relationship was observed.
Martín
M J
MJ
Laboratoire de Pharmacognosie et de Pharmacodynamie, Faculté de Pharmacie, Universidad de Sevilla, Espagne.
Alarcón
C
C
Motilva
V
V
D000818:Animals; D001834:Body Water / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000652:urine*; D004928:Escin / Q000494:pharmacology*; D004929:Esculin / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004573:Electrolytes; D004929:Esculin; D004928:Escin
Effets de l'aescine et de l'aesculine sur l'excrétion rénale d'eau et d'électrolytes chez le rat.