Risk: benefit ratio in the treatment of psoriasis with systemic retinoids.
This is a review of the efficacy of etretinate/acitretin in the treatment of psoriasis and of the currently reported side-effects. The data indicate that retinoids bring significant improvement (if not total clearing) with frequent low-morbidity but rarely serious side-effects. The most serious side-effect of etretinate/acitretin is teratogenicity.
Halioua
B
B
Department of Dermatology, Cantonal University Hospital, Geneva, Switzerland.
Saurat
J H
JH
D000014:Abnormalities, Drug-Induced; D017255:Acitretin; D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D005050:Etretinate / Q000009:adverse effects*; D005128:Eye Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012307:Risk Factors; D012871:Skin Diseases / Q000139:chemically induced; D014212:Tretinoin / Q000009:adverse effects / Q000031:analogs & derivatives*
D008055:Lipids; D014212:Tretinoin; D005050:Etretinate; D017255:Acitretin