Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I or CD64).
Immune interferon (IFN-gamma) induces in human neutrophils accumulation of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I, CD64) with a mechanism that is independent from de novo protein synthesis and from activation of the Na+/H+ antiporter. Monocyte-derived macrophages can also be induced to express high levels of Fc gamma R-I mRNA by IFN-gamma, without requirement of protein synthesis. Unlike what is observed in neutrophils, induction by IFN-gamma of macrophage Fc gamma R-I mRNA was significantly depressed by the Na+/H+ antiporter inhibitor amiloride. These results indicate that phagocytes' Fc gamma R-I mRNA induction by IFN-gamma is regulated by different mechanisms depending on the target cells.
Cassatella
M A
MA
Institute of General Pathology, University of Verona, Italy.
Flynn
R M
RM
Amezaga
M A
MA
Bazzoni
F
F
Vicentini
F
F
Trinchieri
G
G
D000584:Amiloride / Q000494:pharmacology; D000943:Antigens, Differentiation / Q000096:biosynthesis / Q000235:genetics*; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D011961:Receptors, Fc / Q000096:biosynthesis / Q000235:genetics*; D017452:Receptors, IgG
D000943:Antigens, Differentiation; D012333:RNA, Messenger; D011961:Receptors, Fc; D017452:Receptors, IgG; D000584:Amiloride; D007371:Interferon-gamma