Severe hepatotoxic reaction with progression to cirrhosis after use of a novel retinoid (acitretin).
We report the case of a 50-year-old female who suffered from severe palmar and plantar pustulosis. During treatment with acitretin, a novel oral retinoid, which is the main derivative of etretinate, the patient developed a severe hepatotoxic reaction. Subsequent histological studies strongly suggested the development of liver cirrhosis. Reversible elevation of serum aminotransferase values during treatment with acitretin has been reported. However, the present observation indicates that severe hepatotoxic injury may also follow treatment with this agent.
van Ditzhuijsen
T J
TJ
Division of Gastrointestinal and Liver Disease, St. Radboud University Hospital, Nijmegen, The Netherlands.
van Haelst
U J
UJ
van Dooren-Greebe
R J
RJ
van de Kerkhof
P C
PC
Yap
S H
SH
D017255:Acitretin; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D012871:Skin Diseases / Q000188:drug therapy; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D014212:Tretinoin; D017255:Acitretin