Antibody response to viral proteins U (vpu) and R (vpr) in HIV-1-infected individuals.
Antibodies to E. coli-produced HIV-1 vpr and vpu were determined by enzyme immunoassay in serial sets of sera from 72 men seroconverting for antibodies to HIV-1 structural proteins, and from 196 initially symptom-free men who were positive for such antibodies at study entry. First detection of vpr- and vpu-specific antibodies always was within 12 months of seroconversion for antibodies to structural proteins. In the combined cohort of 268 men, vpr- and vpu-specific antibodies were found persistently in 26 and 43% of men, respectively. Vpr- and vpu-specific antibodies were transiently detected in 3 and 7%, respectively, and intermittently detected in 18 and 13% of men, respectively. No association was found between the patterns of vpr- or vpu-specific antibody response and clinical outcome. In subjects with different patterns of vpr- and vpu-specific antibody response, no clear temporal relationship existed between the appearance or disappearance of antibodies and the onset of HIV-1-related disease.
Reiss
P
P
Department of Virology, University of Amsterdam, The Netherlands.
Lange
J M
JM
de Ronde
A
A
de Wolf
F
F
Dekker
J
J
Danner
S A
SA
Debouck
C
C
Goudsmit
J
J
D003430:Cross-Sectional Studies; D016336:Gene Products, vpr; D015483:HIV Antibodies / Q000096:biosynthesis*; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012191:Retroviridae Proteins / Q000276:immunology*; D054334:Viral Regulatory and Accessory Proteins; D054325:vpr Gene Products, Human Immunodeficiency Virus; D000086082:Viroporin Proteins
D016336:Gene Products, vpr; D015483:HIV Antibodies; D054298:Human Immunodeficiency Virus Proteins; D012191:Retroviridae Proteins; D054334:Viral Regulatory and Accessory Proteins; D054325:vpr Gene Products, Human Immunodeficiency Virus; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins