[Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture].
The effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture were studied. In human fetal trachea, a small dose of arsenic (1 mumol As) induced hyperplasia of the epithelium; 3-9 mumol As induced hyperplasia and cellular atypia in the epithelium, and hyperplasia and squamous metaplasia in the adenoepithelium. Similar effects were not observed in rat tracheae. MNNG and B(a)P induced hyperplasia, squamous metaplasia and dysplasia in human fetal tracheal and rat tracheal epithelia respectively, and MNNG also induced hyperplasia and squamous metaplasia in human fetal tracheal adenoepithelium. The data suggest that 1) arsenic may be carcinogenic to the human respiratory tract but not to the rat; and 2) human tissues in organ culture are very useful for detecting carcinogens and for studying carcinogenesis.
Dong
J
J
Institute of Oncology, Beijing.
D000818:Animals; D001151:Arsenic / Q000633:toxicity; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001564:Benzo(a)pyrene; D002273:Carcinogens; D004848:Epithelium / Q000187:drug effects; D005333:Fetus; D006801:Humans; D008679:Metaplasia; D008769:Methylnitronitrosoguanidine; D009924:Organ Culture Techniques; D010087:Oxides; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D014132:Trachea / Q000187:drug effects* / Q000473:pathology; D014134:Tracheal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D001152:Arsenicals; D002273:Carcinogens; D010087:Oxides; D008769:Methylnitronitrosoguanidine; D001564:Benzo(a)pyrene; D001151:Arsenic; D000077237:Arsenic Trioxide