title: Immunosuppressive drugs inhibit class II antigen (HLA-D) synthesis by B and T lymphocytes.
abstract: The influence of immunosuppressive drugs on class II (HLA-D) antigen synthesis and expression by monocytes and B and T cells was studied. The constitutive HLA-D expression on monocytes and malignant B cells was resistant, while the acquisition of those markers by stimulated T cells very sensitive to immunosuppression. Active derivative of cyclophosphamide (4HCy) and cyclosporine proved to be most efficacious inhibitors of class II antigens.
authors: Department of Immunology, Transplantation Institute, Warsaw.
authors: M
authors: M
authors: Nowaczyk
authors: A
authors: A
authors: Pluta
authors: M
authors: M
authors: Modlińska
authors: J
authors: J
authors: Bukowska
authors: A
authors: A
authors: Górski
mesh_terms: D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D006681:HLA-D Antigens / Q000096:biosynthesis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D006681:HLA-D Antigens; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; C011272:perfosfamide