[Value of karyotype in psychiatry: the 3-D syndrome (dysthymia-dysgonosomia-deterioration). First clinical, cytogenetic, anatomical correlation].
The systematic study of the karyotype in Adult Psychiatry reveals among the group of periodical psychoses the existence of the 3-D Syndrome, marked by long clinical cycles, a course towards a dementia, the presence of a X-dysgonosomy with mosaicism, a relative and better clinical response with the use of lithium than with the use of tricyclic antidepressants. These characteristics discriminate the 3-D syndrome from the periodical manic depressive psychosis, which neither includes the course towards a dementia nor does it include until now identified cellular abnormalities. From the anatomical point of view the brain is quasi-normal, when the ultimate phase is a dementia. The 3-D Syndrome seems to be linked with a phenomenon of chromosomal instability. The caryotype takes a part among the usual biological tests in psychiatry.
Pascalis
J G
JG
Clinique de Psychiatrie, C.H.U.-H.R.D., Reims, France.
Bajolle
F
F
Teyssier
J R
JR
Pluot
G
G
D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D001921:Brain / Q000473:pathology; D002869:Chromosome Aberrations; D003704:Dementia / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D010200:Panic; D011618:Psychotic Disorders / Q000235:genetics*; D013577:Syndrome; D014960:X Chromosome
Intérêt du caryotype en psychiatrie: le syndrome 3-D (dysthymie-dysgonosomie-détérioration). Première confrontation clinique, cytogénétique et anatomique.