Congenital cytomegalovirus infection as a preventable complication of maternal transfusion. A case report.
Transfusion-mediated cytomegalovirus (CMV) infection among neonates and nonpregnant, adult female surgical patients has been described thoroughly. A case of symptomatic congenital CMV infection developed after a maternal transfusion during pregnancy. It is estimated that 2.5-12.5% of individual blood units mediate CMV infection though inadvertent transfusion of CMV-infected leukocytes. The use of CMV-seronegative or deglycerolized blood may eliminate or considerably reduce the risk of transfusion-mediated primary CMV infection in pregnant women and their fetuses. CMV-seronegative or deglycerolized blood is used routinely in the case of CMV-susceptible neonates and immunocompromised individuals who require a transfusion. Whenever possible, CMV-seronegative or deglycerolized blood should be used for transfusions in pregnant women who are CMV seronegative or whose serologic status is unknown.
McGregor
J A
JA
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver 80262.
Rubright
G
G
Ogle
J W
JW
D000328:Adult; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006400:Hematocrit; D006801:Humans; D010923:Placenta Previa / Q000150:complications; D011247:Pregnancy; D065227:Transfusion Reaction; D014592:Uterine Hemorrhage / Q000209:etiology / Q000628:therapy*