[Specifics of participation of dopaminergic and serotoninergic systems of the brain in latent inhibition based on pharmacological models].
Single intraperitoneal injections of haloperidol (0.5 mg/kg) or sertralin (5 mg/kg) or 20 preexpositions of conditional stimulus before conditioning induced similar changes of passive avoidance reactions of rats. The combinative application of drugs (sertralin 1h and bupropion 30 min before conditioning) simultaneously enhancing activity of serotonin and dopamine in brain did not produce changes of passive avoidance reaction comparing with intact control. The results obtained showed that high selective drugs and analysis of latent inhibition of some parameters enable creation of pharmacological models and their use as instrument at experimental study of neurochemical mechanisms of attention.
Loskutova
L V
LV
Luk'ianenko
F Ia
FIa
D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D016642:Bupropion; D004298:Dopamine / Q000378:metabolism*; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D011427:Propiophenones / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D020280:Sertraline
D000928:Antidepressive Agents; D011427:Propiophenones; D012702:Serotonin Antagonists; D016642:Bupropion; D012701:Serotonin; D015057:1-Naphthylamine; D006220:Haloperidol; D020280:Sertraline; D004298:Dopamine
Spetsifika uchastiia dofamin- i serotoninergicheskoĭ sistem mozga v latentnom tormozhenii na primere farmakologicheskikh modeleĭ.