Fos and jun: two into one will go.
c-jun was the first oncogene to be identified as a transcription factor thus realizing the long-standing prediction that gene regulation plays a fundamental role in growth control. Not so predictable was that this protein is assisted in its function by a second proto-oncogene, c-fos; that the transcription factor they help comprise transducers hormonal signals; and that each are the archetypal members of gene families. Here, I describe the remarkable progress that has been made from the initial characterization of these oncogenes to our current understanding of their normal cellular function.
Woodgett
J R
JR
Ludwig Institute for Cancer Research, London, UK.
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D004268:DNA-Binding Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors