GABA withdrawal syndrome: a model of the epilepsia partialis continua.
After the chronic infusion of GABA into the cortex of baboon Papio Papio, a sudden stop of the infusion provoked cortical epileptic discharges around the infused area. And the baboon exhibited partial epilepsy for about 3 days. The result suggested that GABA withdrawal syndrome should be a good model not only to understand the mechanism of epilepsia partialis continua but also partial epilepsy with a circumscribed cortical focus.
Kunimoto
M
M
Department of Neurosurgery, Asahikawa Medical College.
Tanaka
T
T
Fukuda
H
H
Yonemasu
Y
Y
Naquet
R
R
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D010215:Papio; D013226:Status Epilepticus / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000633:toxicity*
D005680:gamma-Aminobutyric Acid