Pharmacokinetic curve fitting when the experimental error of the concentration-time data is represented by a relative error model.
When the experimental error of concentration-time data is represented by the relative error model (i.e. constant coefficient of variation) two approaches (direct input of concentration-time data with 1/C2i as a weighting factor, and input of logarithmically transformed concentration-time data) are equally effective in pharmacokinetic modelling. Advantages of the latter approach are discussed.
Zhi
J G
JG
Department of Pharmacy Services, Hartford Hospital, CT 06115.
Nightingale
C H
CH
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006020:Glycopeptides / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin