title: [Dynamic left ventricular obstruction increased by nitroglycerin in elderly patients with hypertension and concentric left ventricular hypertrophy].
abstract: Left ventricular outflow tract (LVOT) obstruction has been observed in elderly patients with concentric hypertrophic hypertensive cardiomyopathy (HHCM) and no significant valvular disease or regional wall motion abnormalities. In order to determine whether nitroglycerin (NTG) can increase the intraventricular obstruction, we performed echocardiographic (echo) and doppler studies, before and during administration of sublingual NTG (0.8 mg). Twenty patients (n = 20) with long-standing hypertension (19 women and 1 man, mean age 78 +/- 8 yr, mean duration of hypertension 13 +/- 10 yrs were examined. The clinical findings in 17 patients were: angina 5 (29%), dyspnea 9 (53%), syncope or malaise 4 (23%). Electrocardiographic criteria of left ventricular hypertrophy was present in 4 patients and an increased cardio-thoracic ratio (greater than 0.5) in 9 cases. The following echo parameters were determined using M-mode echocardiograms: LV end-diastolic (LVID) and systolic diameter (LVIS), fractional shortening (FS), ventricular septum thickness (IVST), posterior wall thickness (PWT) and the ratio ISVT/PWT (less than 1.3 in all patients). LVM could be calculated in 15 patients and was corrected for body surface area (LVMI). Pulsed and continuous wave Doppler study showed a characteristic late-peaking velocity waveform. We localized the elevated velocities in the LVOT and determined before and during administration of NTG: LVOT peak velocities (V) and peak intraventricular gradients (G) using simplified Bernoulli equation. Results were as follows: [table: see text] Mild mitral regurgitation was observed in 14 patients (70%) and mitral annular calcifications in 11 (55%). Systolic function, as assessed by FS, was normal in all patients. NTG induced a significant acceleration of the LVOT velocities in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Service de cardiologie, hôpital Saint-Antoine, Paris.
authors: A
authors: A
authors: Cohen
authors: H
authors: H
authors: Raffoul
authors: B
authors: B
authors: Diebold
authors: C
authors: C
authors: Albo
authors: B
authors: B
authors: Chevalier
authors: A
authors: A
authors: Francillon
authors: J Y
authors: JY
authors: Le Heuzey
authors: P
authors: P
authors: Abastado
authors: L
authors: L
authors: Rozenstajn
authors: J
authors: J
authors: Valty
mesh_terms: D000368:Aged; D006332:Cardiomegaly / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D005996:Nitroglycerin / Q000009:adverse effects
chemical_list: D005996:Nitroglycerin
vernacular_title: Obstruction dynamique intraventriculaire gauche aggravée par la nitroglycérine chez les patients hypertendus âgés avec une hypertrophie ventriculaire gauche concentrique.