Effect of tumour angiogenesis factor on proliferation of endothelial cell and tube formation.
The effect of a tumour angiogenesis factor on proliferation of various kinds of cells was examined in vitro. The factor (TAF) a polypeptide of 14000 molecular weight, was extracted and purified from the conditioned medium of ovarian clear cell carcinoma cell line (HUOCA-II). TAF at concentrations of 10 ng/ml and 100 ng/ml promoted proliferation of the endothelial cells and induced tube formation. However, it had no stimulatory effect on the proliferation of fibroblasts, endometrial columnar cells, squamous epithelial cells or cancer cells.
Ishiwata
I
I
Ishiwata Obstetrics and Gynecology Hospital, Ibaraki, Japan.
Ishiwata
C
C
Soma
M
M
Naik
D R
DR
Hashimoto
H
H
Sudo
T
T
Ishikawa
H
H
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D009369:Neoplasms / Q000098:blood supply*; D011651:Pulmonary Artery / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure; D014471:Umbilical Veins / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure
D043925:Angiogenesis Inducing Agents