[Effect of sanguiritrine on the functional activity of fibroblast lysosomes].
Kinetics of sanguiritrine consumption by L cells of LSM substrain was studied in cell culture. About half of the drug used was absorbed by cells within 20 min. Sanguiritrine inhibited the lysosomal hydrolases (cathepsin D, beta-D-galactosidase and N-acetyl-beta-D-glucosaminidase) activity by 50% at concentration 2.10(-4) M. The drug a concentration 4.10(-4) M inhibited acid lipase by 55% and acid phosphatase by 58%.
Beliaeva
T N
TN
Bulychev
A G
AG
Lasskaia
O E
OE
Semenova
E G
EG
D000118:Acetylglucosaminidase / Q000037:antagonists & inhibitors; D000135:Acid Phosphatase / Q000037:antagonists & inhibitors; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D053119:Benzophenanthridines; D002402:Cathepsin D / Q000037:antagonists & inhibitors; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D007546:Isoquinolines; D007700:Kinetics; D008049:Lipase / Q000037:antagonists & inhibitors; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors*
D000470:Alkaloids; D000935:Antifungal Agents; D053119:Benzophenanthridines; D007546:Isoquinolines; C005705:sanguinarine; D008049:Lipase; D000135:Acid Phosphatase; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase; D002402:Cathepsin D
Deĭstvie sangviritrina na funktsional'nogo aktivnost' lizosomnogo apparata fibroblastov.