title: Cardiac valve replacement with glutaraldehyde preserved aortic allografts.
abstract: From September 1984 to December 1988, 144 patients underwent cardiac valve replacement using glutaraldehyde preserved stent mounted aortic allografts. The mean age was 21.4 years (54.9% were 15 years old or younger). The mitral valve was replaced in 125 patients, the aortic valve in 7, the pulmonary valve in 3, the tricuspid in 1, the mitral and tricuspid in 1, and the aortic and mitral in 7. Hospital mortality was 2.8% (4 patients). Total follow-up was 396.3 patient-years and the mean follow-up was 2.8 years per patient. The 5-year actuarial survival was 73.8% +/- 11.9%. The 4-year actuarial survival for patients aged 15 or younger was 81.4% +/- 7.1%. The overall mortality was 2.8% +/- 0.8%/per patient-year. The incidence of valve-related complications was 4.8% +/- 1.1%/per patient-year, and the calcification rate was 3.0% +/- 0.9%/per patient-year and was the main complication reported in 12 patients, all under the age of 15 years. It occurred 14-47 months after implantation (mean 32.7 months). Five-year actuarial freedom from valve dysfunction due to calcification was 82.6% +/- 5.0% and for patients aged 15 or younger was 69.9% +/- 8.8%. The incidence of reoperation was 3.3% +/- 0.9%/per patient-year. These initial results demonstrate a 5-year actuarial freedom from primary valve failure due to fibrocalcification superior to the results obtained with xenobioprostheses in the paediatric age group.
authors: Hospital Felicio Rocho, Belo Horizonte, M.G., Brazil.
authors: C A
authors: CA
authors: Salles
authors: E
authors: E
authors: Buffolo
authors: J C
authors: JC
authors: Andrade
authors: J T
authors: JT
authors: Mendonça
authors: J
authors: J
authors: Wanderley Neto
authors: I S
authors: IS
authors: Casagrande
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000637:transplantation*; D001705:Bioprosthesis / Q000706:statistics & numerical data*; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006350:Heart Valve Prosthesis / Q000401:mortality*; D006351:Heart Valves / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011475:Prosthesis Failure; D012086:Reoperation; D015607:Stents; D015996:Survival Rate
chemical_list: D011093:Polyethylene Terephthalates