Persistent effects of chronic exposure to styrene on the affinity of neostriatal dopamine D-2 receptors.
We have investigated whether chronic exposure to styrene could inflict persistent effects on the binding characteristics of dopamine D-2 agonist binding sites in rat neostriatal membranes. Styrene exposure (1000 ppm, 6 months, 16 h/d overnight, and left without exposure for another 5 months) caused a marked increase (+160%) in the IC50 value of dopamine without significantly affecting the total amount of specifically bound [3H]raclopride. The specific [3H]raclopride binding in membranes from subcortical limbic areas was too low to yield acceptable displacement curves. These data indicate that chronic exposure to styrene can induce a persistent decrease in affinity of the neostriatal dopamine D-2 agonist binding sites, possibly mediated by membrane perturbations.
von Euler
G
G
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
Bjørnaes
S
S
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D018492:Dopamine Antagonists; D020891:Raclopride; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D017448:Receptors, Dopamine D2; D012457:Salicylamides / Q000378:metabolism; D020058:Styrene; D013343:Styrenes / Q000633:toxicity*
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D013343:Styrenes; D020891:Raclopride; D020058:Styrene