Atrial peptides inhibit protein kinase C-mediated contraction in rat aorta.
The effects of atriopeptin III on phorbol ester-induced contraction were examined in aorta from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Precontracted SHR aorta was less responsive than WKY aorta to atriopeptin III-induced relaxation. Additionally, SHR aorta had significantly greater basal and phorbol ester-stimulated protein kinase C (PKC) activity than WKY aorta. The altered PKC response as well as hyporesponsiveness to atriopeptin III in SHR aorta may contribute to an altered vascular response and to the pathogenesis of hypertension.
Sauro
M D
MD
Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa 33612.
Fitzpatrick
D F
DF
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D006973:Hypertension / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D015240:Phorbol 12,13-Dibutyrate; D009320:Atrial Natriuretic Factor; D011493:Protein Kinase C