title: Argyrophilic nuclear organiser region counts in locally advanced breast carcinoma treated by chemotherapy before surgery.
abstract: The value of argyrophilic nuclear organiser region (AgNOR) counts in assessing histologically the effects of combination chemotherapy given to eleven patients with locally advanced breast cancer before mastectomy was studied. AgNOR counts were significantly reduced (P less than 0.001) in the post-chemotherapy, surgically excised residual tumour specimens compared with the initial diagnostic biopsy specimens. AgNOR counts could be used to monitor the effects of chemotherapy on breast cancer.
authors: Laboratoire d'Anatomie Pathologique, Institut Jean Godinot, Reims, France.
authors: W V
authors: WV
authors: Bogomoletz
authors: C
authors: C
authors: Pourny
authors: B
authors: B
authors: Didier
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D011300:Preoperative Care; D012834:Silver / Q000378:metabolism*
chemical_list: D012834:Silver