5-HT3 receptor antagonist ondansetron does not alter effects of amphetamine on DA metabolism.
The present study was carried out to elucidate the effect of ondansetron, a selective 5-HT3 receptor antagonist, on amphetamine-induced changes in monoamine metabolism in major ascending dopamine (DA) neurons. Amphetamine (2 mg kg-1 s.c.) significantly decreased the concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in nucleus caudatus and nucleus accumbens. Pretreatment with ondansetron (0.1 mg kg-1 and 1 mg kg-1 s.c., 15 min before amphetamine) failed to modify the effects of amphetamine. It is concluded that acute blockade of central 5-HT3 receptors by ondansetron does not prevent amphetamine-induced changes in monoamine metabolism in nigrostriatal or mesolimbic dopaminergic areas.
Koulu
M
M
Department of Pharmacology, University of Turku, Finland.
Lappalainen
J
J
Hietala
J
J
Sjöholm
B
B
Virtanen
R
R
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D017294:Ondansetron; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists
D015306:Biogenic Monoamines; D007093:Imidazoles; D012702:Serotonin Antagonists; D015102:3,4-Dihydroxyphenylacetic Acid; D017294:Ondansetron; D000661:Amphetamine; D004298:Dopamine; D006719:Homovanillic Acid