[In vitro stability of amikacin and ciprofloxacin administered through a Y-shaped catheter connection with 2 total parenteral nutrition formulations with different pH].
We studied the stability of amikacin and ciprofloxacin in in vitro coinfusion with two total parenteral nutrition. The antibiotic concentrations were determined by EMIT and HPLC for amikacin and ciprofloxacin, respectively. There were not significant differences between theoretical and measured concentrations. The emulsion stability were analyzed by visual inspection, Coulter-Counter and optic microscopy. The emulsion was stable and we didn't find any particle of size greater than 6 microns.
Balet
A
A
Servicio Farmacia, Hospital Sta. Creu i St. Pau., Barcelona.
Cardona
D
D
Pastor
C
C
Márquez
M
M
D000583:Amikacin / Q000008:administration & dosage / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D010289:Parenteral Nutrition, Total
D002939:Ciprofloxacin; D000583:Amikacin
Estabilidad "in vitro" de la amicacina y ciprofloxacina administradas en "Y" con dos nutriciones parenterales totales (NPT) de diferentes pH.