Angiotensin II antiserum decreases luteinizing hormone-releasing hormone in the median eminence and preoptic area of the rat.
Ovariectomized female rats were sacrificed 3 h after intracerebroventricular microinjection of normal rabbit serum (NRS), specific antiserum against angiotensin II (AB-AII) or atrial natriuretic factor (AB-ANF). AB-AII decreased plasma LH by 50% and LH-RH content by 70% in the median eminence and medial preoptic area, respectively, but did not change plasma FSH when compared to animals which received NRS. There was no difference in these parameters when the animals were injected with AB-ANF or NRS. These results indicate that endogenous AII plays a physiological role in LH release acting directly or indirectly through LH-RH neurons of the median eminence and medial preoptic area.
Franci
C R
CR
Departamento de Fisiologia, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto, Brasil.
Anselmo-Franci
J A
JA
McCann
S M
SM
D000804:Angiotensin II / Q000008:administration & dosage / Q000502:physiology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood*; D007106:Immune Sera / Q000008:administration & dosage; D007986:Luteinizing Hormone / Q000097:blood*; D008473:Median Eminence / Q000378:metabolism*; D011301:Preoptic Area / Q000378:metabolism*; D051381:Rats
D007106:Immune Sera; D000804:Angiotensin II; D007987:Gonadotropin-Releasing Hormone; D009320:Atrial Natriuretic Factor; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone