title: Plasma atrial natriuretic peptide in young normotensive subjects with a family history of hypertension and in young hypertensive patients.
abstract: Plasma atrial natriuretic peptide (ANP) behavior was evaluated in 26 untreated essential hypertensives, 21 normotensives, and 20 normotensives with hypertensive heredity under normal sodium intake (120 mEq of Na+/day). All subjects were men, mean age 22.1 +/- 1.9 years. Plasma ANP was evaluated by radioimmunoassay on samples collected in supine position upon waking and again after 1 h of orthostatism. Resulting data showed that ANP in hypertensives (supine = 44.5 +/- 19.4 pg/mL, orthostatism = 24.1 +/- 11.6 pg/mL) was at higher levels than in controls (supine = 38.3 +/- 19.4 pg/mL, orthostatism = 19.9 +/- 10.6 pg/mL) or in normotensives with hypertensive heredity (supine = 42.1 +/- 16.8 pg/mL, orthostatism = 23.2 +/- 10.8 pg/mL). Mean ANP level was higher in the latter group than in the control group (supine = +9%; orthostatism = +14.2%). In conclusion, plasma ANP is raised in young essential hypertensives, resulting in slightly elevated levels in normotensives with hypertensive heredity.
authors: Institute of I Clinica Medica, University of Rome La Sapienza, Italy.
authors: A
authors: A
authors: Santucci
authors: C
authors: C
authors: Ferri
authors: I
authors: I
authors: Cammarella
authors: S
authors: S
authors: Valentino
authors: C
authors: C
authors: Bellini
authors: S
authors: S
authors: Tani
authors: A
authors: A
authors: Musca
authors: F
authors: F
authors: Balsano
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001795:Blood Pressure Determination / Q000379:methods; D005069:Evaluation Studies as Topic; D005192:Family Health; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics / Q000652:urine; D008297:Male; D011187:Posture; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin