[Detection and its clinical significance of IgM antibody in cerebrospinal fluid in patients with tuberculous meningitis].
Specific antibody for IgM in cerebrospinal fluid (CSF) of 45 patients with tuberculous meningitis (TBM), 33 patients with non-TBM and 51 control patients was determined by enzyme-linked immunosorbent assay, and compared with specific antibody for IgG. The sensitivity and specificity was 71.1% and 98.8% for IgM antibody, and 88.9% and 96.4% for IgG antibody respectively, but the positive rate of IgM antibody at early stage of TBM was higher than that of IgG antibody. There was a highly significant positive correlation between positive rates of the two types of antibody and contents of protein in CSF. The sensitivity and specificity was 97.8% and 98.8% respectively in detecting both the IgM and IgG antibodies in CSF simultaneously, which can be used as a supplementary method for the diagnosis of TBM.
Hu
Z Y
ZY
Ningxia Medical College, Yinchuan.
D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology; D014390:Tuberculosis, Meningeal / Q000175:diagnosis*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014373:Tuberculin