title: High-performance liquid chromatography of the drug fosenopril.
abstract: High-performance liquid chromatography was used to determine the purity and impurities of fosinopril, an angiotensin-converting enzyme inhibitor used to treat hypertension. Purity values are determined using a silica column and usually are above 99%. All known possible impurities, including stereoisomeric impurities, can be resolved and quantified by injecting solutions of fosinopril onto three separate columns; silica, strong anion exchange and phenyl. Typical impurity contents total 0.5%. Validation data and a study of properties of fosinopril in solution is included.
authors: Squibb Institute for Medical Research, New Brunswick, NJ 08903-0191.
authors: J
authors: J
authors: Kirschbaum
authors: J
authors: J
authors: Noroski
authors: A
authors: A
authors: Cosey
authors: D
authors: D
authors: Mayo
authors: J
authors: J
authors: Adamovics
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D017328:Fosinopril; D011392:Proline / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D017328:Fosinopril