Laparoscopic ovarian diathermy in the management of anovulatory infertility in women with polycystic ovaries: endocrine changes and clinical outcome.
Twenty-one nulliparous oligomenorrheic women with polycystic ovaries, complaining of infertility (mean duration 6 years) refractory to medical treatment, underwent laparoscopic ovarian diathermy. Eleven had adhesions and/or endometriosis. Regular ovulatory cycles ensued in 17 women (81%). In 9 responders there was a transient rise in mean follicle-stimulating hormone from 5.0 +/- 0.4 (standard error of the mean [SEM]) to 6.7 +/- 0.5 mIU/mL on postoperative day 1 and a fall in testosterone from 2.6 +/- 0.2 to 1.9 +/- 0.2 nmol/L by day 8. Luteinizing hormone fell from 19 +/- 1.2 to 10.4 +/- 1.2 mIU/mL by the follicular phase of the next cycle. Eleven women have conceived 13 pregnancies; 3 miscarried, 7 were delivered at term and 3 are ongoing. Ovarian diathermy is a useful option in women with polycystic ovaries complaining of refractory anovulatory infertility.
Armar
N A
NA
University College, London, United Kingdom.
McGarrigle
H H
HH
Honour
J
J
Holownia
P
P
Jacobs
H S
HS
Lachelin
G C
GC
D000328:Adult; D000735:Androstenedione / Q000097:blood; D000858:Anovulation / Q000209:etiology / Q000601:surgery*; D003687:Dehydroepiandrosterone / Q000097:blood; D004564:Electrocoagulation / Q000592:standards*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000601:surgery*; D010535:Laparoscopy / Q000592:standards*; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000378:metabolism / Q000601:surgery*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000601:surgery*; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone