title: [Preoperative radio-chemotherapy and radical surgery for advanced carcinomas of the oral cavity. 4-year results of a prospective therapy study with DOSAK].
abstract: Based on the postoperative data evaluated in September 1989, the results of a regional prospective treatment study conducted by the DOSAK on preoperative radio-chemotherapy and radical surgery for carcinomas of the oral cavity and the oropharynx are presented. In the univariate analysis the histologic lymph node findings after pretreatment, the histologic grading, and the TPI correlated well with the survival rates. The multivariate analysis confirmed that the histologic demonstration of vital tumor cells in the neck lymph nodes after the end of pretreatment is of grat prognostic relevance. The histologic degree of differentiation, the demonstration of vital tumor cells in the primary tumor area after pretreatment and the length of time between radiotherapy and surgery were of secondary importance.
authors: Klinik für Gesichts- und Kieferchirurgie der Universitätsklinik Essen.
authors: C
authors: C
authors: Mohr
authors: W
authors: W
authors: Bohndorf
authors: H
authors: H
authors: Gremmel
authors: F
authors: F
authors: Härle
authors: J E
authors: JE
authors: Hausamen
authors: H
authors: H
authors: Hirche
authors: M
authors: M
authors: Molls
authors: K H
authors: KH
authors: Renner
authors: J
authors: J
authors: Ruether
authors: H
authors: H
authors: Sack
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001317:Austria; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D015999:Multivariate Analysis; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D013557:Switzerland; D013997:Time Factors; D016896:Treatment Outcome
vernacular_title: Präoperative Radio-Chemotherapie und radikale Operation fortgeschrittener Mundhöhlenkarzinome. 4Jahresergebnisse einer prospektiven Therapiestudie des DOSAK.