title: Nesidioblastosis associated with chronic experimental pancreatitis produced by a scorpion toxin, tityustoxin, in rats.
abstract: Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was injected intravenously (50 micrograms/kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesion characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals.
authors: Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil.
authors: G
authors: G
authors: Novaes
authors: A
authors: A
authors: Chetto-de-Queiroz
authors: C
authors: C
authors: De-Carvalho-Cardoso
authors: M H
authors: MH
authors: Burlacchini-de-Carvalho
authors: L A
authors: LA
authors: Ribeiro-Filho
authors: A
authors: A
authors: Oliveira-Gonçalves
mesh_terms: D000818:Animals; D002908:Chronic Disease; D007275:Injections, Intravenous; D008297:Male; D010182:Pancreatic Diseases / Q000473:pathology*; D010195:Pancreatitis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012604:Scorpion Venoms / Q000633:toxicity*
chemical_list: D012604:Scorpion Venoms; C003609:tityustoxin