title: Parenteral nutrition and oral intake: effect of branched-chain amino acids.
abstract: The effect of peripheral parenteral nutrition (PPN) on voluntary food intake was examined in healthy male subjects. Each study (lasting 17 to 19 days) was divided into three phases: Ringer's lactate (RL); PPN administered as a combination of glucose, fat, and amino acids; and finally RL. During the middle phase, some of the subjects received a parenteral formula in which half of the amino acids had been replaced with the branched-chain amino acids (BCPPN). When PPN was infused, subjects reduced their food intake within 48 hours by approximately 80% of the infused calories (p less than 0.001) within 48 hours, whereas intake was reduced by less than 40% of the infused calories when BCPPN was infused. Use of branched-chain amino acid-enriched parenteral nutrition may minimize the reduction in food intake seen during intravenous nutrition, possibly hastening a return to normal eating.
authors: Department of Anesthesiology, Montefiore Medical Center, Bronx, New York 10467.
authors: K M
authors: KM
authors: Gil
authors: B
authors: B
authors: Skeie
authors: V
authors: V
authors: Kvetan
authors: M I
authors: MI
authors: Friedman
authors: J
authors: J
authors: Askanazi
mesh_terms: D000293:Adolescent; D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D002149:Energy Intake; D006801:Humans; D008297:Male; D010288:Parenteral Nutrition / Q000379:methods*
chemical_list: D000597:Amino Acids, Branched-Chain