title: [Serum pepsinogen I and duodenal ulcer disease].
abstract: Duodenal ulcer is a common disease. It has always been said that it results from an imbalance between aggressive forces (HC1 and pepsin) and defensive forces that act on the mucosa. More attention has traditionally been paid to acid and relative less interest to pepsin. Two types of pepsinogen have been recognized as precursors of peptic activity in the lumen. Pepsinogen I has been more frequently implicated in ulcerogenesis. The aim of this review is to consider the different current pathophysiologic and clinical aspects, and to take into account its importance as a predictive and genetic marker in duodenal ulcer disease, which is always a challenge in the daily practice of gastroenterologists.
authors: Hospital González Plaza, Universidad de Carabobo.
authors: J
authors: J
authors: Kolster
mesh_terms: D004381:Duodenal Ulcer / Q000097:blood / Q000178:diet therapy / Q000209:etiology*; D005744:Gastric Acid / Q000378:metabolism; D005819:Genetic Markers; D006801:Humans; D010435:Pepsinogens / Q000097:blood / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D005819:Genetic Markers; D010435:Pepsinogens
vernacular_title: Pepsinógeno I sérico y enfermedad ulcerosa duodenal.