[The role of thymus gland in the regulation of the activity of peripheral T-lymphocytes in the process of spontaneous blastogenesis in mice].
The total count, spontaneous proliferation and proliferative response of thymic and spleen T-cells in mixed lymphocyte culture and Con A-induced suppressor activity do not reveal significant disorders in 10-14-month A/Sn and C3H/He mice with spontaneous mammary tumors (weight under 2-3 g). However, these indices are quite different in varying age (2, 6, 12 month) A/Sn mice and C57Bl/6 mice with low rates of spontaneous tumors. The analysis of thymus-dependent immunity changes observed with age shows that relatively intensive migration of nonmature thymocytes, T-suppressor precursors is noted in mice with high cancer incidence. This phenomenon is considered to be one of major mechanisms regulating immune response in spontaneous-carcinogenesis.
Stankevich
S A
SA
Ogreba
V I
VI
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007958:Leukocyte Count / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*
D003208:Concanavalin A
Uchastie timusa v reguliatsii aktivnosti perifericheskikh T-limfo- tsitov v protsesse spontannogo blastomogeneza u mysheĭ.