Scatter factor regulates vascular endothelial cell motility.
Scatter factors (SFs) are mesenchymal cell-derived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at less than 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.
Rosen
E M
EM
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Carley
W
W
Goldberg
I D
ID
D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects*; D016207:Cytokines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000502:physiology*; D005347:Fibroblasts; D017228:Hepatocyte Growth Factor; D006801:Humans; D066298:In Vitro Techniques; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D016207:Cytokines; D011506:Proteins; D017228:Hepatocyte Growth Factor