title: Circadian variations in plasma melatonin, FSH, LH, and prolactin and testosterone levels in infertile men.
abstract: Circadian patterns of plasma melatonin, FSH, LH, prolactin, and testosterone were studied in 10 healthy men, 20 men with oligozoospermia, and 8 men with azoospermia. Circadian rhythms were found in concentrations of melatonin and prolactin, with higher values at night in comparison with daytime levels. In patients with oligozoospermia and azoospermia an elevation in melatonin levels was observed, and an increase in melatonin concentrations occurred before onset of darkness (i.e., at 2000 h). Levels of FSH, LH, and prolactin were elevated in infertile patients. The possibilities that an increase in melatonin concentrations is either the primary feature that leads to the regression of the seminiferous epithelium or is secondary and depends on elevated gonadotropins and/or prolactin levels are discussed.
authors: Department of Pathological Anatomy, Medical Academy, Lodz, Poland.
authors: M
authors: M
authors: Karasek
authors: M
authors: M
authors: Pawlikowski
authors: B
authors: B
authors: Nowakowska-Jankiewicz
authors: H
authors: H
authors: Kolodziej-Maciejewska
authors: J
authors: J
authors: Zieleniewski
authors: D
authors: D
authors: Cieslak
authors: F
authors: F
authors: Leidenberger
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D003624:Darkness; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008550:Melatonin / Q000097:blood*; D009845:Oligospermia / Q000097:blood*; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood*
chemical_list: D006065:Gonadotropins, Pituitary; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008550:Melatonin