HLA-B27, arthritis and spondylitis in an isolated community in Papua New Guinea.
Rheumatic complaints in a sample of 109 individuals from an isolated community in Papua New Guinea were documented and 92/109 were tissue typed for HLA-B27. Eleven (10.1%) subjects had active peripheral arthritis, but 38 (34.9%) had previously suffered an episode of arthritis. In those with current peripheral arthritis, 6/10 (60%) were HLA-B27 positive compared to 15/58 (25.9%) with no history of arthritis (P less than 0.05). In total, 16/34 (47.1%) with either current or a previous history of peripheral arthritis were HLA-B27 positive compared to the 15/58 (25.9%) with no history of arthritis (P less than 0.05). Back pain was common. In 84/109 individuals the cause was mechanical injury; 24/72 (33.3%) of these were HLA-B27 positive. Ankylosing spondylitis was identified in one HLA-B27-negative woman.
Clunie
G P
GP
University College and Middlesex School of Medicine, London.
Koki
G
G
Prasad
M L
ML
Richens
J E
JE
Bhatia
K
K
Keat
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D001416:Back Pain; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010219:Papua New Guinea / Q000453:epidemiology; D015995:Prevalence; D012008:Recurrence; D013167:Spondylitis, Ankylosing / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D013710:Tendons / Q000473:pathology
D015796:HLA-B27 Antigen