Effects of norepinephrine on hepatic amino acid metabolism in isolated perfused rat liver.
The effects of norepinephrine (NE) on hepatic amino acid exchanges were studied in the isolated perfused rat liver using a recirculating system with a medium containing amino acids at twice physiologic concentrations. Norepinephrine induced a significant decrease (25%) in portal blood flow at a concentration of 2 ng/ml (10(-8) M). The hormone also increased total hepatic amino acid uptake, essentially through a switch from glutamine release to net uptake. There was no modification in free intracellular amino acids, but glycogen was slightly decreased, and glucose production was increased. Taken as a whole, these results suggest that NE modulates hepatic protein balance.
De Bandt
J P
JP
Laboratoire de Biochimie A, Hopital Saint Antoine, Paris, France.
Ballet
F
F
Cynober
L
L
Rey
C
C
Coudray-Lucas
C
C
Giboudeau
J
J
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D005973:Glutamine / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D005973:Glutamine; D009638:Norepinephrine