Debrisoquine oxidation phenotype and susceptibility to lung cancer.
1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the normal population. 3. There was no tendency for subjects with lung cancer to metabolise debrisoquine more rapidly than non-cancer subjects. 4. It is concluded that debrisoquine metabolic phenotype is not a good predictor of risk of developing lung cancer in the population at large.
Speirs
C J
CJ
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
Murray
S
S
Davies
D S
DS
Biola Mabadeje
A F
AF
Boobis
A R
AR
D000230:Adenocarcinoma / Q000139:chemically induced / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D018288:Carcinoma, Small Cell / Q000139:chemically induced / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000378:metabolism; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype; D012306:Risk; D012907:Smoking / Q000378:metabolism
D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin