Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in north west Europe and Siberia.
Recently morbilliviruses were isolated from harbour seals (Phoca vitulina) in North West Europe (phocid distemper virus-1: PDV-1) and from Baikal seals (Phoca sibirica) in Siberia (phocid distemper virus-2: PDV-2) during outbreaks of severe disease which resembled distemper in dogs. PDV-1 and PDV-2 were passaged in SPF dogs, in which they caused distemper-like disease symptoms, and were subsequently passaged in Vero cells in which they caused cytopathic changes. PDV-1, PDV-2, and canine distemper virus (CDV) were compared with respect to their biological, morphological, physical, protein chemical, and antigenic properties. It was concluded that PDV-1 should be considered a newly recognized member of the genus Morbillivirus, whereas PDV-2 proved to be quite similar if not identical to CDV.
Visser
I K
IK
Laboratory of Immunobiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Kumarev
V P
VP
Orvell
C
C
de Vries
P
P
Broeders
H W
HW
van de Bildt
M W
MW
Groen
J
J
Teppema
J S
JS
Burger
M C
MC
UytdeHaag
F G
FG
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D010872:Caniformia / Q000382:microbiology*; D004196:Disease Outbreaks / Q000662:veterinary; D004285:Dogs; D007158:Immunologic Techniques; D010252:Paramyxoviridae / Q000145:classification / Q000302:isolation & purification*; D010253:Respirovirus Infections / Q000382:microbiology / Q000662:veterinary*; D046048:Seals, Earless / Q000382:microbiology*; D012692:Serial Passage; D013047:Specific Pathogen-Free Organisms; D014764:Viral Proteins / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014764:Viral Proteins