Effect of toremifene on estrogen primed vaginal mucosa in postmenopausal women.
The antiestrogenic effect of 20 mg toremifene daily for 7 days and 68 mg for 5 days was studied in postmenopausal women volunteers primed for 7 days with estradiol valerate (2 mg daily orally) which was continued throughout the study. A control group received estrogen only and a reference group estrogen with 60 mg tamoxifen for 5 days. No treatment opposed the action of the estrogen on the endometrium but both 68 mg toremifene and 60 mg tamoxifen statistically significantly decreased the maturity index of vaginal cells on day 13. A decrease was also evident on day 18 with 20 mg toremifene.
Mäenpää
J
J
Department of Obstetrics and Gynecology, University of Turku, Finland.
Söderström
K O
KO
Grönroos
M
M
Taina
E
E
Hajba
A
A
Kangas
L
L
D001706:Biopsy; D004717:Endometrium / Q000166:cytology; D004958:Estradiol / Q000097:blood / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D017312:Toremifene; D014621:Vagina / Q000187:drug effects*
D004965:Estrogen Antagonists; D012738:Sex Hormone-Binding Globulin; D013629:Tamoxifen; D004958:Estradiol; D017312:Toremifene; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone