Postirradiation changes in small intestine mucosa of piglets selectively decontaminated by peroral antibiotics.
There was performed light microscopic and morphometric comparison of changes in the intestinal mucosa structure after the irradiation of the lower part of body by radiation 60Co in a dose of 12 Gy, observed the third day after irradiation in piglets kept under conventional conditions and the fifth, the fifteenth and the twentieth days after irradiation in piglets kept under the conditions of selective decontamination by peroral antibiotics. The non-irradiated animals kept conventionally as well as under the conditions of decontamination served as controls. The estimation was performed on transverse slices of the cranial part of jejunum and of the caudal part of ileum. The slices were stained by the method hematoxylin-eosin. The drawings prepared with the help of the projective microscope Pictoval were used for measuring on the apparatus for the quantitative analysis of image MOP AM 03. A markedly lower damage of the intestinal mucosa was evidenced in piglets selectively decontaminated by peroral antibiotics. In the studied time intervals after irradiation in a dose of 12 Gy, the epithelial cover of mucosa, the crypt epithelium and the general outline of mucosa are much better maintained. The favourable effect of the selective decontamination on the maintenance and regeneration of the mucosa of jejunum and ileum is confirmed by a range of morphometric parameters.
Pospísilová
J
J
Medical Faculty, Palacký University, Olomouc, Czechoslovakia.
Kamarád
V
V
Svoboda
V
V
Mandel
L
L
Talafantová
M
M
Trebichavský
I
I
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology / Q000528:radiation effects; D007421:Intestine, Small / Q000382:microbiology / Q000473:pathology / Q000528:radiation effects*; D011836:Radiation Tolerance / Q000187:drug effects; D013552:Swine
D000900:Anti-Bacterial Agents