title: Changes in circulating inhibin levels during pregnancy and early lactation in the Japanese monkey.
abstract: Changes in immunoreactive (ir-) inhibin concentrations in serum throughout pregnancy and early lactation up to one month after parturition were characterized in 6 Japanese monkeys (Macaca fuscata fuscata) by a heterologous radioimmunoassay (RIA) based on a bovine RIA. Serum levels of FSH, LH/monkey chorionic gonadotropin (mCG), estradiol-17 beta, and progesterone were also monitored for the entire period. Ir-inhibin levels in the serum were low (under 0.5 ng/ml) before conception. Three marked increases in serum ir-inhibin levels were found during pregnancy. The first increase was noted during early pregnancy, with a peak (2.2 +/- 0.2 ng/ml) at Day 22 of pregnancy (Day 0 = day of LH surge). The second increase was noted after Day 38 until Day 72 of pregnancy, when a peak value was noted (19.0 +/- 1.4 pg/ml). Plateau levels were maintained until late pregnancy, and a final rise was evident near the term with a peak (36.7 +/- 3.8 ng/ml) at Day 158 of pregnancy, 5 days before parturition. After parturition, ir-inhibin levels in the serum plummeted to nonpregnant levels within one day, and were maintained during early lactation. The first rise in serum inhibin during pregnancy was parallel to the rise of mCG and estradiol-17 beta, and the second and third rise were well correlated with serum estradiol-17 beta. Serum FSH was maintained at low levels throughout pregnancy, followed by a slight increase after parturition when serum inhibin decreased abruptly. Both bioactivity and immunoreactivity of inhibin were detected in the placental homogenates obtained at 120 days of pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Primate Research Institute, Kyoto University, Aichi, Japan.
authors: M
authors: M
authors: Nozaki
authors: G
authors: G
authors: Watanabe
authors: K
authors: K
authors: Taya
authors: Y
authors: Y
authors: Katakai
authors: I
authors: I
authors: Wada
authors: S
authors: S
authors: Sasamoto
authors: K
authors: K
authors: Oshima
mesh_terms: D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis; D005498:Follicular Phase; D007265:Inhibins / Q000097:blood*; D007774:Lactation / Q000378:metabolism*; D008183:Luteal Phase / Q000502:physiology; D007986:Luteinizing Hormone / Q000096:biosynthesis; D008251:Macaca / Q000502:physiology*; D010053:Ovary / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone