[Comparative studies on antifertility mechanism and toxicology of Tripterygium wilfordii monomer T4 and gossypol].
Inhibition of spermatogenesis and turnover of basic nuclear protein in late elongated spermatids of rat testis by Tripterygium wilfordii monomer T4 was more obvious than that by gossypol. Clustered positive deposits of gamma-GT, ALP reaction were found in the inner edges of epididymal epithelium. Head and tail separation, mid-piece coiling and axial fiber dislocation of epididymal spermatozoa in T4 treated rats were more obvious than those of gossypol-treated rats. Mitochondrial LDH, LDH-X and MDH were also found to be inhibited by T4. T4 did not significantly affect enzyme activities in kidney and liver, though it did cause slight changes. Effects of T4 on the chief rat organs were milder than those of gossypol, except for a more obvious antifertility effect. The authors suggest that T4 may be developed into an ideal male contraceptive.
Lu
Q
Q
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D004822:Epididymis / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000494:pharmacology* / Q000633:toxicity; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D006072:Gossypol