B cell development in the bone marrow.
Recent years have produced considerable progress in defining stages in the development of B cells in vivo, and in revealing interactions with regulatory molecules and cells. Studies of the phenotype and population dynamics of precursor B cells in mouse bone marrow have quantitated cell production at sequential steps of differentiation and have also indicated a substantial cell death. The proliferation of precursor B cells is influenced both by systemic factors and by cytokines derived from bone marrow stromal cells. In situ immunolabeling has revealed that early precursor B cells are closely associated with subosteal stromal cells, aberrant B lineage cells appear to be deleted by macrophages and terminal B cells mature within the lumen of vascular sinusoids before being released. The findings lead to working models of the in vivo differentiation, regulation and microenvironmental organization of B cell genesis in the bone marrow.
Osmond
D G
DG
Department of Anatomy, McGill University, Montreal, Canada.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001853:Bone Marrow / Q000276:immunology / Q000502:physiology*; D002450:Cell Communication; D006133:Growth Substances / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D008262:Macrophage Activation; D051379:Mice; D008954:Models, Biological
D006133:Growth Substances