title: Structure of the thromboxane receptor antagonist EP 092.
abstract: 7-(3-[1-(4-Phenylthiosemicarbazono)ethyl]-bicyclo[2.2.1]hept-2- yl)-5-heptenoic acid, C23H31N3-O2S, Mr = 413.7, monoclinic, P2(1)/a, a = 12.9650 (7), b = 11.2081 (6), c = 16.8941 (12) A, beta = 110.452 (5) degrees, V = 2300.2 A3, Z = 4, Dx = 1.194 g cm-3, Mo K alpha, lambda = 0.71073 A, mu = 1.55 cm-1, F(000) = 888, T = 298 K. Final R = 0.0472 with 2778 independent data. EP 092 is a thromboxane receptor antagonist akin to many other analogues of the thromboxane A2 [Wilson & Jones (1985). Adv. Prostaglandin Thromboxane Leukotriene Res. 14, 393-425].
authors: Department of Biochemistry, University of Edinburgh, Scotland.
authors: A
authors: A
authors: McAlpine
authors: L
authors: L
authors: Sawyer
authors: P
authors: P
authors: Taylor
authors: A J
authors: AJ
authors: Blake
mesh_terms: D008968:Molecular Conformation; D011465:Prostaglandins, Synthetic; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*; D017482:Receptors, Thromboxane; D013931:Thromboxanes / Q000037:antagonists & inhibitors*; D014961:X-Ray Diffraction
chemical_list: D011465:Prostaglandins, Synthetic; D011982:Receptors, Prostaglandin; D017482:Receptors, Thromboxane; D013931:Thromboxanes; C045332:EP 092