[Contrary effects of hypertension and cigarette smoking on the conditions of wall shear in large arteries].
Systolic wall shear conditions were studied in the brachial artery of 4 groups of subjects including 11 non-smokers normotensives (NSNT), 25 non smokers hypertensives (NSHT), 21 smokers normotensives (SNT) and 10 smokers hypertensives (SHT). Brachial artery diameter (D) and systolic centerline blood velocity (VCLS) were measured with a pulsed Doppler device and blood viscosity at 96 sec-1 was measured with a coaxial cylinder viscometer. The wall shear rate (gamma S) corresponding to systolic velocity was calculated using a Womersley model of pulsatile flow according to the formula: alpha = (D/2) (omega/mu) 1/2, omega being the angular pulse frequency and mu the kinematic viscosity. The wall shear stress was then calculated as the product between wall shear rate and viscosity. The analysis of results in the 4 groups showed that both hypertension and smoking increased blood viscosity bu their effects on wall shear were opposite since hypertension decreased shear and stress while smoking did not change it. However, in hypertensive patients, smoking induced a clear elevation in wall shear rate and stress, whereas in smokers hypertension did not change shear conditions. Thus, opposite and interactive effects of hypertension and smokers exist on large artery wall shear phenomena which could induce differences in response of functional and structural endothelial cells to these two vascular risk factors.
Simon
A
A
Centre de diagnostic, INSERM U 28, hôpital Broussais, Paris.
Del Pino
M
M
Flaud
P
P
Filitti
V
V
Levenson
J
J
D000328:Adult; D001783:Blood Flow Velocity; D001809:Blood Viscosity; D001916:Brachial Artery; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood* / Q000503:physiopathology; D013314:Stress, Mechanical; D014465:Ultrasonics
Effets opposés de l'hypertension artérielle et du tabagisme sur les conditions de cisaillement pariétal au niveau des grosses artères.