title: Maternal serum hCG and SP1 in pregnancies with fetal aneuploidy.
abstract: In a retrospective study, maternal serum levels of chorionic gonadotropin (hCG) and pregnancy specific beta 1-glycoprotein (SP1) from 63 pregnancies with aneuploid fetuses were compared to the levels observed in pregnancies with a chromosomally normal fetus. Thirty-eight percent of the abnormal pregnancies had elevated levels (greater than 2.0 multiples of the normal median [MoM]) of hCG and 14% had depressed levels (less than 0.25 MoM). With a false-positive rate of 5%, 44% of the 42 fetuses with trisomy 21 would have been detected by elevated hCG levels. With the same false-positive rate, only 21% had elevated SP1 levels. hCG was significantly depressed in 12 pregnancies affected by fetal trisomy 18.
authors: Institut für Humangenetik, Universitat Göttingen, West Germany.
authors: I
authors: I
authors: Bartels
authors: M
authors: M
authors: Thiele
authors: M H
authors: MH
authors: Bogart
mesh_terms: D000782:Aneuploidy; D006063:Chorionic Gonadotropin / Q000097:blood*; D002869:Chromosome Aberrations; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D011268:Pregnancy-Specific beta 1-Glycoproteins