title: Hemispheric CBF-alterations in the time course of focal and diffuse brain injury.
abstract: Hemispheric CBF-alterations were studied in the time course of focal and diffuse-brain injury in a series of 25 head injured patients. Repeated 133 Xe CBF measurements with a mobile 10 detector system were performed in order to evaluate hemispheric CBF and cerebral vasoreactivity after change of PaCO2. Focal brain injury influenced hemispheric CBF varying in the time course: A hyperperfusion could be found within the first seven days after injury in 55 percent, whereas a hypoperfusion could be detected during the whole examination period in 18 percent. In diffuse injury we never saw such CBF abnormalities. On the other hand hemispheric CO2-reactivity was disturbed in focal and diffuse lesions, whereas a correlation between altered CBF at rest and CO2-reactivity could be only detected in 40% in focal injury. This investigations demonstrates no significant general, however, a partial influence of morphological damage upon cerebral microcirculation.
authors: Department of Neurosurgery, University of Würzburg, Federal Republic of Germany.
authors: J
authors: J
authors: Meixensberger
authors: A
authors: A
authors: Brawanski
authors: M
authors: M
authors: Holzschuh
authors: I
authors: I
authors: Danhauser-Leistner
authors: W
authors: W
authors: Ullrich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002536:Cerebral Arteries; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D012146:Rest; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D002245:Carbon Dioxide