title: [Thrombolytic therapy in the treatment of thromboembolism of the right cardiac cavity during pulmonary embolism: our experience with rt-PA and review of the literature].
abstract: In 4 consecutive patients admitted for multiple pulmonary embolism 2-dimensional echocardiography showed large right atrial migrant thromboemboli in transit, floating and prolapsing into the right ventricle in diastole. This pattern was always associated with the echocardiographic signs of pulmonary hypertension. All the patients were treated with intravenous infusion of 100 mg of rt-PA in 3 hours. rt-PA determined the dissolution and disappearance of the right atrial thromboemboli (it took 4 hours in 2 patients and 5 hours in the remaining 2), and the concomitant disappearance of the echocardiographic signs of pulmonary hypertension. During and after the rt-PA therapy there was no evidence of further pulmonary embolism. The fibrinolytic treatment for right atrial thromboemboli during multiple pulmonary embolism is a promising alternative to right atrial thrombectomy: our results indicate that rt-PA acts rapidly and is effective and safe; if these results will be confirmed in a larger group of patients, rt-PA could become the first-choice therapy of right atrial thromboembolus.
authors: Cattedra di Cardiologia, Università degli Studi, Brescia.
authors: C
authors: C
authors: Cuccia
authors: P
authors: P
authors: Franzoni
authors: M
authors: M
authors: Volpini
authors: S
authors: S
authors: Scalvini
authors: M
authors: M
authors: Volterrani
authors: G
authors: G
authors: Musmeci
authors: M
authors: M
authors: Metra
mesh_terms: D000368:Aged; D004452:Echocardiography; D005260:Female; D006325:Heart Atria; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications*; D013923:Thromboembolism / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010959:Tissue Plasminogen Activator
vernacular_title: La terapia trombolitica nel trattamento dei tromboemboli nelle cavità cardiache destre in corso di embolia polmonare: nostra esperienza con l'rt-PA e revisione della letteratura.