The regulation of gene expression and the molecular basis of cancer.
Over the last few years, the advent of new genetic techniques allowed a detailed analysis of the structural and functional organization of the genome and the genes in a living cell. After the discovery of cellular oncogenes, genes which are implicated in cell growth control and differentiation, recent investigations provided evidence to a crucial role played by certain gene regulatory DNA elements and oncoproteins in the molecular mechanisms of carcinogenesis.
Pauly
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Laboratoire de recherche sur le cancer et les maladies du sang, Zone industrielle Grasbusch, Leudelange, Luxembourg.
Dicato
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D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics
D004273:DNA, Neoplasm; D015513:Oncogene Proteins