Natural killer cells and Tac antigen in the hypertension of pregnancy.
Of the immunological alterations in pregnancy hypertension were studied peripheral blood lymphocyte subpopulation in normal and hypertensive pregnancies by means of monoclonal antibodies. In pregnant women with hypertension an increase was found in NK activity. It was also shown that an increase in circulating T cells expressing Tac antigen occurred in women with pregnancy hypertension. These preliminary data on Tac antigen suggest that there is an activation of Leu 3 cells; which may introduce the concept of Leu 3 activity like NK activity. Further studies on this subject could explain that the concept of Leu 3 activity is correct.
Cignetti
M
M
Department of Obstetrics and Gynecology, University of Ancona, Italy.
Garzetti
G G
GG
Marchegiani
F
F
Fabris
N
N
Romanini
C
C
D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis* / Q000276:immunology
D015375:Receptors, Interleukin-2