Intestinal transport in cystic fibrosis (CF).
Ion transport was measured in jejunal biopsies using short-circuit current (SCC) as an index of net electrogenic ion transport. Increases in SCC associated with stimulation of Cl- secretion were observed in control tissues, but CF tissues did not exhibit such a response, indicating a failure of intestinal Cl- secretion. The rise in SCC associated with Na(+)-linked glucose absorption was greater in CF tissues than in controls, reflecting an enhanced active absorption of glucose.
Hardcastle
J
J
Department of Biomedical Science, University Western Bank, Sheffield.
Taylor
C J
CJ
Hardcastle
P T
PT
Baxter
P S
PS
Goldhill
J
J
D001693:Biological Transport, Active; D003550:Cystic Fibrosis / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007477:Ions; D007583:Jejunum / Q000378:metabolism*
D007477:Ions