[Immunological effects of captopril and ramipril in patients with hypertension].
Fifteen patients with essential hypertension underwent treatment with captopril (7 patients) and ramipril (8 patients). The drugs belong to angiotensin-converting enzyme (ACE) inhibitors. Pretreatment immunological examination and that after a 10-15-week course of the above therapy involved measurements of IgG, IgA, IgE and beta 2-microglobulin. The analysis of the trend in the immunological indices demonstrated that captopril, distinct from ramipril by the presence of a sulfhydryl group, caused a decrease in immunological parameters suggesting a potential role of culfhydryl groups in mediating ACE inhibitor action on the immune system. The immunological properties of captopril may appear useful in various systemic diseases.
Vil'chinskaia
M Iu
MIu
Nasonov
E L
EL
Zharova
E A
EA
Panfilov
V V
VV
Masenko
V P
VP
Oshchepkova
E V
EV
Beliakova
E V
EV
D000328:Adult; D001643:Bridged Bicyclo Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004406:Dysgammaglobulinemia / Q000139:chemically induced; D006801:Humans; D006942:Hypergammaglobulinemia / Q000139:chemically induced; D006973:Hypertension / Q000188:drug therapy* / Q000276:immunology; D017098:IgA Deficiency; D017099:IgG Deficiency; D007070:Immunoglobulin A / Q000187:drug effects; D007073:Immunoglobulin E / Q000187:drug effects; D007074:Immunoglobulin G / Q000187:drug effects; D007075:Immunoglobulin M / Q000187:drug effects; D007136:Immunoglobulins / Q000187:drug effects*; D008297:Male; D017257:Ramipril
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007073:Immunoglobulin E; D002216:Captopril; D017257:Ramipril
Immunologicheskiĭ éffekt kaptoprila i ramiprila u bol'nykh gipertonicheskoĭ bolezn'iu.