Evidence for a possible role for serotonergic systems in the control of cerebral blood flow.
Cerebral blood flow and glucose utilisation were measured in rats using [14C]iodoantipyrine and [14C]2-deoxyglucose quantitative autoradiography respectively following repeated exposure to the serotonergic neurotoxin methylenedioxyamphetamine. In both control and treated animals blood flow and glucose use were similarly correlated but the ratio was increased following lesion. Some focal increases in flow were greatly in excess of metabolic demand. These results are consistent with a cerebrovascular vasoconstrictor role for serotonin.
McBean
D E
DE
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, U.K.
Sharkey
J
J
Ritchie
I M
IM
Kelly
P A
PA
D015104:3,4-Methylenedioxyamphetamine / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D009411:Nerve Endings / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011903:Raphe Nuclei / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
D001786:Blood Glucose; D002245:Carbon Dioxide; D012701:Serotonin; D015104:3,4-Methylenedioxyamphetamine; D010100:Oxygen