title: Divergent lipoprotein responses to fish oils with various ratios of eicosapentaenoic acid and docosahexaenoic acid.
abstract: To determine if the ratio of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in fish oil had an effect on plasma lipid responses, we randomly fed eight normolipidemic men three 36%-fat diets containing primarily butter, EPA-rich pollock oil, or DHA-rich tuna or salmon-blend oils. Plasma EPA and DHA reflected the amounts in the diets. Compared with values for the butter diet, very-low-density lipoprotein (VLDL) triglycerides decreased equally (71-78%) with all diets; low-density lipoprotein (LDL) cholesterol (LDL-C) and apolipoprotein B decreased 26% and 13%, respectively, on the tuna and salmon-blend oil but did not change (-1%) and increased 19% with the pollock diet; high-density lipoprotein cholesterol (HDL-C) and lipoproteins A-I and A-II decreased with all diets but more with the pollock diet than with the tuna and salmon diets. The 23-31% decrease in total cholesterol on the tuna and salmon diets resulted mostly from decreased LDL-C whereas the 16% decrease on pollock oil resulted mostly from a decrease in HDL-C.
authors: Department of Medicine, University of Washington, Seattle 98195.
authors: M T
authors: MT
authors: Childs
authors: I B
authors: IB
authors: King
authors: R H
authors: RH
authors: Knopp
mesh_terms: D002079:Butter; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004281:Docosahexaenoic Acids / Q000032:analysis / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000032:analysis / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood; D005395:Fish Oils / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male
chemical_list: D005227:Fatty Acids; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D004281:Docosahexaenoic Acids; D002079:Butter; D002784:Cholesterol; D015118:Eicosapentaenoic Acid