Vesico-ureteric reflux in Down's syndrome: poor prognosis.
Four patients with Down's syndrome and vesico-ureteric reflux (VUR) are reported. VUR was diagnosed in six renal units and three primary nephrectomies were necessary. Three ureters were reimplanted unsuccessfully in two patients. The 50% nephrectomy rate for reflux nephropathy and the 100% failure rate for ureteric reimplantation in Down's syndrome patients are compared with a nephrectomy rate and ureteric reimplantation failure rate of around 1% for primary VUR in other children.
Ahmed
S
S
Department of Surgery, Adelaide Children's Hospital, South Australia.
D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009392:Nephrectomy; D011379:Prognosis; D011859:Radiography; D012092:Replantation; D014513:Ureter / Q000601:surgery; D014519:Ureterostomy; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery