Disodium cromoglycate inhibits immunoglobulin production in vitro without affecting cell growth in human B cell lines.
The effect of disodium cromoglycate (DSCG) on human B cell lines (IM-9, GM-1056, and AF-10) was studied. DSCG inhibited immunoglobulin production by these B cell lines without affecting thymidine uptake or cell number. Thus, in addition to its antiallergic function, DSCG may also act as a B cell-modulating reagent in vitro.
Kimata
H
H
Department of Pediatrics, Kyoto University Hospital, Japan.
Yoshida
A
A
Ishioka
C
C
Mikawa
H
H
D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*
D007136:Immunoglobulins; D004205:Cromolyn Sodium