Carboxypeptidase G2 and trimetrexate cause growth delay of human colonic cancer cells in vitro.
MAWI colonic cancer cells respond to sequential treatment in vitro with carboxypeptidase G2 and trimetrexate by a delay in cell growth as measured by cell numbers, but an increase in incorporation of 75-Se-selenomethionine per cell. The cells are not methionine auxotrophs.
Searle
F
F
Department of Medical Oncology, Charing Cross Hospital (Fulham) London, U.K.
Bagshawe
K D
KD
Pedley
R B
RB
Bradshaw
T
T
Melton
R G
RG
Sherwood
R F
RF
Mellor
B
B
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002268:Carboxypeptidases / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D003470:Culture Media; D006710:Homocysteine / Q000494:pharmacology; D006801:Humans; D008715:Methionine / Q000494:pharmacology; D051379:Mice; D011799:Quinazolines / Q000494:pharmacology*; D011817:Rabbits; D016597:Trimetrexate; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003470:Culture Media; D011799:Quinazolines; D006710:Homocysteine; D008715:Methionine; D002268:Carboxypeptidases; D016597:Trimetrexate