[The establishment of experiment model of gastric dysrhythmia and the study of its mechanism in rabbits].
In fasting and anaesthetic rabbits, the experimental model of gastric dysrhythmia could be produced by electric stimulation of inferior phrenicus vagus and splanchnic nerve for innervation of corpus and antrum, or by left gastric artery infusion of Adr, Ach and glucagon at a steady velocity. The results were as follows: (1) Electrical stimulation of inferior phrenicus vagus at low frequency and intensity could increase the frequency and amplitude of basic electric rhythmia (BER) or slow wave (P less than 0.01), and might induced tachygastria and tachyarrhythmia. Electrical stimulation of splanchnic nerve could increase the frequency and amplitude of BER (P less than 0.05), and might induced bradygastria. (2) Bradygastria could be elicited by left gastric artery infusion of Adr (400 micrograms/kg/h). The frequency and amplitude of BER induced were decreased. Tachyarrhythmia could be elicited by infusion of Ach (400 micrograms/kg/h). The frequency and amplitude of BER induced were increased. Dysrhythmia of BER could be elicited by infusion of glucagon (400 micrograms/kg/h). (3) Electroacupuncture of "Zusanli" acupoint may exhibit double modulated effects on experimental model of gastric dysrhythmia. Different types of gastric dysrhythmia including tachygastria, bradygastria and tachyarrhythmia could turned to approach the normal gastric myoelectric activity. It is revealed that such effects of electroacupuncture may be mediated via autonomic nerve and peripheric special receptors.
Yang
J
J
Institute of Acupuncture and Meridian, Anhui College of Traditional Chinese Medicine, Hefei.
Xu
G
G
Zhang
Q
Q
Liu
W
W
Gou
Y
Y
D015670:Acupuncture Therapy; D000818:Animals; D004558:Electric Stimulation; D015671:Electroacupuncture; D004594:Electrophysiology; D005260:Female; D008297:Male; D010791:Phrenic Nerve; D011817:Rabbits; D013270:Stomach / Q000503:physiopathology; D013272:Stomach Diseases / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*