Respiratory syncytial virus modulation of adult and neonatal lymphocyte mitogenic responses and the role of interferon-gamma.
Infection of human adult and neonatal mononuclear leukocytes (MNLs) with respiratory syncytial virus (RSV) caused significant inhibition of lymphoproliferation in response to various mitogens (heat-killed Staphylococcus aureus, phytohaemagglutinin, concanavalin-A and pokeweed mitogen). Antibody to human interferon-gamma enhanced the RSV-induced suppression of lymphoproliferation in adult, but not neonatal MNLs. These results are consistent with the hypothesis that RSV can suppress the development of a cell-mediated immune response by direct interaction with lymphocytes, and at least in adult cells, interferon-gamma could be implicated in resistance to this action.
Paton
A W
AW
University of Adelaide Department of Paediatrics, Australia.
Goldwater
P N
PN
D000328:Adult; D000906:Antibodies / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects* / Q000382:microbiology; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011994:Recombinant Proteins; D012136:Respiratory Syncytial Viruses
D000906:Antibodies; D008934:Mitogens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D011994:Recombinant Proteins; D003208:Concanavalin A; D007371:Interferon-gamma