title: Interleukin-2 inhibitor in rheumatoid arthritis synovial fluid does not inhibit mononuclear cell responses to mitogens.
abstract: Synovial fluid (SF) from rheumatoid arthritis (RA) patients were tested for their ability to inhibit the proliferative responses of normal peripheral blood mononuclear cells (PBM) to mitogens and interleukin-2 (IL-2). SF significantly inhibited the responses to concanavalin A (CON A) and phytohaemagglutinin (PHA), but significantly enhanced the responses to IL-2. Similarly, SF mononuclear cells (SFM) were hyporesponsive to CON A and PHA compared with autologous PBM, but hyper-responsive to IL-2. It is concluded that an IL-2 inhibitor in RA SF is unlikely to be the cause of SFM hyporesponsiveness to mitogens.
authors: Department of Pathology, University of Bristol, Medical School, UK.
authors: A P
authors: AP
authors: Hollander
authors: C J
authors: CJ
authors: Elson
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology
chemical_list: D007376:Interleukin-2; D010835:Phytohemagglutinins; D003208:Concanavalin A