Phasic plasma atrial natriuretic polypeptide changes in DOCA-salt hypertensive rats.
We determined plasma and cardiac immunoreactive atrial natriuretic polypeptide (ir-ANP) levels in rats treated with deoxycorticosterone acetate (DOCA) and sodium chloride for 1, 7, and 28 days. Systolic blood pressure of DOCA-salt rats began to increase from the 7th day and reached 191 +/- 7 mmHg at the 28th day. One day after treatment with DOCA-salt, plasma levels of ir-ANP were increased compared to that of control rats. This was accompanied by decreased cardiac ir-ANP content. However, at the 7th day of DOCA-salt treatment, both plasma and cardiac ir-ANP levels of DOCA-salt rats were not different from those of control animals. At the 28th day, DOCA-salt rats had high plasma ir-ANP levels and no significantly different cardiac ir-ANP content compared to the controls. These data suggest that there are time-related changes in plasma ANP concentration during the development of DOCA-salt hypertension and higher plasma ANP levels might not necessarily be associated with a decreased cardiac ANP content.
Sato
Y
Y
Fourth Department of Internal Medicine, School of Medicine, University of Tokyo, Japan.
Ito
Y
Y
Ando
K
K
Ogata
E
E
Fujita
T
T
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D003900:Desoxycorticosterone; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012965:Sodium Chloride; D013599:Systole; D013997:Time Factors
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor; D003404:Creatinine; D012083:Renin