title: Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia.
abstract: The c-erbB-1 and c-erbB-2 proto-oncogenes are frequently activated by gene amplification and overexpression in a variety of human cancers. In an analysis of a large series of benign and malignant thyroid tumours, no abnormalities of structure or expression of either of c-erbB-1 or c-erbB-2 were found. Activation of these oncogenes is not a necessary event in neoplasia of this epithelial system.
authors: ICRF Molecular Oncology Group, Hammersmith Hospital, London, U.K.
authors: N R
authors: NR
authors: Lemoine
authors: F S
authors: FS
authors: Wyllie
authors: J R
authors: JR
authors: Lillehaug
authors: S L
authors: SL
authors: Staddon
authors: C M
authors: CM
authors: Hughes
authors: R
authors: R
authors: Aasland
authors: J
authors: J
authors: Shaw
authors: J E
authors: JE
authors: Varhaug
authors: C L
authors: CL
authors: Brown
authors: W J
authors: WJ
authors: Gullick
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D015870:Gene Expression; D015321:Gene Rearrangement; D006801:Humans; D009841:Oligonucleotides / Q000032:analysis; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D009841:Oligonucleotides