Immunosuppressive drugs inhibit class II antigen (HLA-D) synthesis by B and T lymphocytes.
The influence of immunosuppressive drugs on class II (HLA-D) antigen synthesis and expression by monocytes and B and T cells was studied. The constitutive HLA-D expression on monocytes and malignant B cells was resistant, while the acquisition of those markers by stimulated T cells very sensitive to immunosuppression. Active derivative of cyclophosphamide (4HCy) and cyclosporine proved to be most efficacious inhibitors of class II antigens.
Nowaczyk
M
M
Department of Immunology, Transplantation Institute, Warsaw.
Pluta
A
A
Modlińska
M
M
Bukowska
J
J
Górski
A
A
D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D006681:HLA-D Antigens / Q000096:biosynthesis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D006681:HLA-D Antigens; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; C011272:perfosfamide