Effects of centrally administered atrial natriuretic polypeptide on sympathetic nerve activity and blood flow to the kidney in conscious rats.
Effects of intracerebroventricular (i.c.v.) administration of atrial natriuretic polypeptide (ANP) on renal sympathetic nerve activity (RSNA) and renal blood flow (RBF) were examined in conscious rats. Administration of ANP had no appreciable effects on baseline RSNA and RBF. The pressor response induced by i.c.v. angiotensin II (AII) was attenuated by prior i.c.v. administration of ANP but no significant effect of ANP was observed on the AII-induced bradycardia and inhibition of RSNA. The result shows that centrally administered ANP has little effect on basal RSNA and RBF but it antagonizes the pressor response caused by AII without affecting induced changes in heart rate and RSNA.
Kannan
H
H
Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ueta
Y
Y
Nakamura
T
T
Yamashita
H
H
Hayashida
Y
Y
D000200:Action Potentials / Q000187:drug effects; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D007668:Kidney / Q000294:innervation*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor