Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats.
Saturable [3H]-8OHDPAT binding to 5HT-1A receptors in membranes prepared from hippocampus and frontal cerebral cortex of alcohol-preferring P rats and of alcohol-nonpreferring NP rats has been compared. The Bmax values or densities of recognition sites for 5HT-1A receptors in both brain areas of the P rats are 39 and 131 percent, respectively, higher than those in the NP rats. The corresponding KD values are 38 and 44 percent lower in the P rats than in the NP rats, indicating higher affinities of the recognition sites for the 5HT-1A receptors in hippocampus and cerebral cortex of the P rats. These findings indicate either an enrichment of 5HT-1A receptor density during selective breeding for alcohol preference or an upregulation of 5HT-1A receptors developed as an adaptation to lower presynaptic concentrations of 5HT found in these brain areas of P rats as compared with the NP rats.
Wong
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Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
Threlkeld
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PG
Lumeng
L
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Li
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TK
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000378:metabolism; D015854:Up-Regulation
D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin