The regulation of beta-interferon gene expression.
Expression of the beta-interferon gene is induced in many cell lines by viral infection or treatment with double-stranded RNA. The sequence requirements for this induction have been analysed in detail. A minimal inducible element has a modular structure which is consistent with a model in which induction requires de-repression of a dominant negative regulatory domain and the activation of at least two positive regulatory domains. A number of cellular factors that can bind to the beta-IFN promoter have been identified, and some of these are only detectable after induction, including the transcription factor NF-kappa B. cDNA clones have recently been isolated which may encode regulatory factors for beta-IFN expression.
Goodbourn
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Gene Expression Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
D000818:Animals; D001483:Base Sequence; D004247:DNA; D005786:Gene Expression Regulation; D006801:Humans; D016899:Interferon-beta / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D012330:RNA, Double-Stranded / Q000502:physiology; D012045:Regulatory Sequences, Nucleic Acid / Q000502:physiology; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction
D012330:RNA, Double-Stranded; D016899:Interferon-beta; D004247:DNA