Determinants of fetal and maternal atrial natriuretic peptide concentrations at delivery in man.
Matched maternal venous (MV), umbilical artery (UA) and umbilical vein (UV) concentrations of atrial natriuretic peptide [ANP] were measured in 36 normotensive women at term delivery (23 vaginal, 13 caesarean) and 17 non-pregnant women in the first half of the menstrual cycle. MV [ANP] at caesarean section was similar to that in non-pregnant women, but UA and UV [ANP] were higher (P less than 0.01 for both). UA, but not UV, [ANP] was markedly raised after vaginal delivery. Plasma concentrations of aldosterone [ALD] were measured in 16 of the matched sets of samples. No statistically significant association was found between [ANP] and [ALD] in either maternal or fetal samples. Neither maternal nor fetal [ANP] correlated with serum Na+ or osmolality, haematocrit, blood pressure or heart rate.
Voto
L S
LS
Department of Obstetrics and Gynaecology, University Hospital, Nottingham.
Hetmanski
D J
DJ
Broughton Pipkin
F
F
D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002585:Cesarean Section; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005498:Follicular Phase / Q000502:physiology; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D014469:Umbilical Arteries; D014471:Umbilical Veins
D000450:Aldosterone; D009320:Atrial Natriuretic Factor