Pharmacokinetics of 2,4,5-T in mice as a function of dose and gestational status.
A pharmacokinetic study was conducted in CD-1 mice with the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) as a function of dose (15, 30, 60, and 90 mg/kg, iv) and gestational status (nonpregnant, day 6, 10, 13, and 17 of gestation, and postpartum). Analysis for 2,4,5-T and its metabolites was based on an electron-capture gas-liquid chromatographic method. Pharmacokinetic stimulation of the blood, urine, and feces data from each mouse was performed on an analog-digital hybrid computer system based on a two-compartment model with parallel, first-order elimination kinetics. Data analysis demonstrated dose-independent kinetics for most pharmacokinetic parameters but a gestational status-dependence. There was a tendency, as indicated by an increase in the biologic half-life and AUC and decrease in clearance and total percent recovery, for pregnant animals to eliminate 2,4,5-T more slowly as gestation progressed, resulting in potentially increasing fetal exposure during the later stages of pregnancy.
Bazare
J J
JJ
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079-9502.
Nelson
C J
CJ
Young
J F
JF
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D002849:Chromatography, Gas; D003203:Computers, Hybrid; D004622:Embryo, Mammalian / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D006207:Half-Life; D051379:Mice; D008954:Models, Biological; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*
D015085:2,4,5-Trichlorophenoxyacetic Acid