Inhibition of cellular infiltration at the site of Arthus reaction by chlorpromazine. Use of a new area integration technique.
Chlorpromazine, an inhibitor of the complement (C) system, inhibited the cellular infiltration at the site of Arthus reaction (AR), as assessed by a newly developed computerized area integration technique (CAIT). This inhibition was rather strong (mean value 92%) and statistically significant according to the classical quotient estimator. This may, at least in part, explain the protection of vessel wall destruction by chlorpromazine in AR, as observed in a previous study. CAIT estimated cellular infiltration in H & E stained skin biopsy sections quantitatively and reliably.
Kammeyer
A
A
Department of Dermatology (Academic Medical Center), University of Amsterdam, The Netherlands.
Abdel Mawla
M Y
MY
Oosterhoorn
A D
AD
Amer
M
M
Asghar
S S
SS
D000818:Animals; D001183:Arthus Reaction / Q000473:pathology*; D002746:Chlorpromazine / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects; D003201:Computers; D008297:Male; D011817:Rabbits; D013223:Statistics as Topic
D002746:Chlorpromazine