Instability of in vitro resistance to imipenem in Pseudomonas aeruginosa.
In 3 from 19 clinical isolates of Pseudomonas aeruginosa imipenem-resistant subpopulations could be detected in vitro. In comparison to their wild strains these imipenem-resistant cells were lacking an outer-membrane-protein of 50 kD. In the subpopulation derived from Pseudomonas aeruginosa 76 resistance to imipenem was found to be instable. It could be lost within a short period of time after subcultivation in the absence of imipenem. Cells with restored sensitivity to imipenem possess the outer membrane protein of 50 kD as the wild strain does.
Wolter
E J
EJ
Institute of Experimental Epidemiology, Wernigerode.
Witte
W
W
D001390:Azlocillin / Q000494:pharmacology; D001398:Aztreonam / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000032:analysis / Q000187:drug effects*
D001425:Bacterial Outer Membrane Proteins; D002939:Ciprofloxacin; D015378:Imipenem; D001398:Aztreonam; D001390:Azlocillin