title: Comparison of the efficacy of dermal formulations of ivermectin and levamisole for the treatment and prevention of Dictyocaulus viviparus infection in cattle.
abstract: Four groups of six parasite-naive calves were infected at seven day intervals with three doses of infective larvae of Dictyocaulus viviparus. Twenty-one days after the first dose three of the groups were treated either with an injectable formulation of ivermectin at a dose rate of 200 micrograms/kg bodyweight, or with pour-on preparations of levamisole at 10 mg/kg or ivermectin at 500 micrograms/kg. On day 28 two calves from each group were slaughtered and their burdens of lungworms counted. On day 35 the remaining calves were reinfected with D viviparus infective larvae at a rate of 80 L3/kg. The levamisole preparation was 94.6 per cent effective and both ivermectin preparations were 100 per cent effective against the initial infections. The ivermectin-treated calves were protected from the reinfection which subsequently became patent in the levamisole-treated and control calves.
authors: Veterinary Research Laboratory, Stormont, Belfast.
authors: S M
authors: SM
authors: Taylor
authors: T R
authors: TR
authors: Mallon
authors: W P
authors: WP
authors: Green
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000517:prevention & control; D003371:Cough / Q000662:veterinary; D004022:Dictyocaulus Infections / Q000188:drug therapy* / Q000517:prevention & control; D005243:Feces / Q000469:parasitology; D007279:Injections, Subcutaneous / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage* / Q000627:therapeutic use; D007978:Levamisole / Q000008:administration & dosage* / Q000627:therapeutic use; D008171:Lung Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D013997:Time Factors
chemical_list: D007978:Levamisole; D007559:Ivermectin