[Acute pharmacokinetics of the Tl+ ion in the rabbit. 3-compartment model].
New Zealand rabbits were used to determine the acute kinetics of the Tl+ ion (0 to 90 minutes) following intravenous administration of two doses of Tl+ (10 mg.kg-1 and 30 mg.kg-1). The rapid disappearance of Tl+ from the blood may be explained by means of an open parallel tricompartmental mamillary model. The most important pharmacokinetic parameters which changed with the dose were Vdl (0.61 +/- 0.08 1.kg-1 for the low dose and 0.59 +/- 0.10 1.kg-1 for the high dose); ABC0-90 (310 +/- 18 mg.ml-1 min-1 for the low dose and 942 +/- 107 Mg.ml-1 min for the high dose; Kd (0.026 +/- 0.005 min-1 for the low dose and 0.037 +/- 0.010 min-1 for the high dose). The importance of the values of the slopes alpha, rho & gamma found by residual methods are discussed and compared with the results reported by other authors working with other species and different times.
Morales-Aguilera
A
A
División de Farmacología, Unidad de Investigación Biomédica del Noreste, IMSS, Monterrey, N.L., México.
Careaga Olivares
J
J
D000818:Animals; D001825:Body Fluid Compartments; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D013793:Thallium / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013793:Thallium; C013707:thallium sulfate
Farmacocinética aguda del ion Tl+ en el conejo. Modelo tricompartamental.