[Ultrastructural characteristics of anti-ischemia protection of intact and hypertrophic myocardium with phosphocreatinine].
Ultrastructural changes in normal and hypertrophied dog hearts under conditions of total ischemia were studied by electron microscope method. In the control group sings of irreversible damage appeared in 90 min, in the presence of phosphocreatine, 10 mM, these changes became apparent in 120 min. In the hypertrophied hearts signs of the irreversible damages became evident in 60 and 90 min in the absence and presence of phosphocreatine, respectively. Ability of phosphocreatine to protect both normal and hypertrophied myocardium allows to use it safely.
Mogilevskiĭ
G M
GM
Sharov
V G
VG
Severin
V V
VV
Semenovskiĭ
M L
ML
D000818:Animals; D006332:Cardiomegaly / Q000473:pathology*; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D003327:Coronary Disease / Q000517:prevention & control*; D004285:Dogs; D006321:Heart / Q000187:drug effects*; D006324:Heart Arrest, Induced; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D010725:Phosphocreatine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
D002314:Cardioplegic Solutions; D010725:Phosphocreatine; C025403:phosphocreatinine
Ul'trastrukturnaia kharakteristika protivoishemicheskoĭ zashchity neizmenennogo i gipertrofirovannogo miokarda fosfokreatininom.