Potentiation by dipyridamole of 5-fluorouridine antitumor activity against a rat adenocarcinoma in vivo.
Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyridamole improved the antitumor activity of 5-FUrd but decreased that of 5-FdUrd.
el Hag
I A
IA
Department of Pathology, University Hospital, Lund, Sweden.
Roos
G
G
Jönsson
P E
PE
Stenram
U
U
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage* / Q000494:pharmacology; D004357:Drug Synergism; D005467:Floxuridine / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
D005467:Floxuridine; C001943:5-fluorouridine; D004176:Dipyridamole; D014529:Uridine