[Gonadal function in adolescents after total body irradiation in bone marrow transplantation].
Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.
Gambarana
D
D
Clinica Pediatrica, Policlinico S. Matteo, Università di Pavia.
Tonani
P
P
Bongiorno
M
M
Focardi
C
C
Biscaldi
I
I
Cerbo
R M
RM
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010053:Ovary / Q000528:radiation effects*; D013737:Testis / Q000528:radiation effects*; D013739:Testosterone / Q000097:blood; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Studio della funzionalità gonadica in adolescenti sottoposti ad irradiazione totale corporea (TBI) per trapianto di midollo osseo (TMO).