Effect of glucocorticoids on arachidonate metabolism and prostaglandin secretion.
The effects of glucocorticoids on eicosanoid synthesis are briefly summarized and issues that remained unresolved or controversial are described. It is also suggested, in view of the present knowledge about the effects of sex steroids on uterine prostaglandin production, that common features may exist between these actions and those of anti-inflammatory steroids.
Duval
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Department of Pharmacology, School of Medicine Necker, Enfants Malades, Paris, France.
D000818:Animals; D017302:Annexins; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000502:physiology; D015777:Eicosanoids / Q000096:biosynthesis* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006801:Humans; D050356:Lipid Metabolism; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D015290:Second Messenger Systems
D017302:Annexins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D002135:Calcium-Binding Proteins; D015777:Eicosanoids; D005227:Fatty Acids; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D011453:Prostaglandins; D016718:Arachidonic Acid; D010740:Phospholipases