title: [Neisseria gonorrhoea in Pikine (Senegal): survey of antibiotic sensitivity].
abstract: The antimicrobial sensitivity of 96 strains of Neisseria gonorrhoeae, isolated in 1987-88 in Pikine, Senegal was determined. Twenty four percent of isolates produced beta-lactamase (PPNG). Among the beta-lactamase negative strains, 27% showed a decreased sensitivity to penicillin (MIC 0.125-0.25 mg/l) and 3% were resistant (MIC greater than or equal to 0.5 mg/l). Seventeen percent of isolates showed a decreased sensitivity to thiamphenicol (MIC 1-4 mg/l) and 7% were moderately resistant to tetracycline (MIC 2-4 mg/l). All isolates were sensitive to spectinomycin and sensitive to moderately sensitive to kanamycin. During an earlier survey performed in 1981, chromosomal resistance to tetracycline was not seen and only 4% of strains were beta-lactamase positive. These results suggest a decreasing antimicrobial sensitivity of N. gonorrhoeae in Pikine. Spectinomycin can be used as a first choice antimicrobial and thiamphenicol may be recommended as a valuable alternative treatment of gonorrhoea in Pikine, Senegal.
authors: Projet Pikine, Coopération Médicale Belge, Dakar, Sénégal.
authors: L
authors: L
authors: Van de Velden
authors: E
authors: E
authors: Van Dyck
authors: I
authors: I
authors: De Schampheleire
authors: Y
authors: Y
authors: Dankaratou
authors: P
authors: P
authors: Piot
mesh_terms: D004352:Drug Resistance, Microbial; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D000198:Spectinomycin / Q000627:therapeutic use; D013753:Tetracycline Resistance; D013839:Thiamphenicol / Q000627:therapeutic use; D014526:Urethritis / Q000382:microbiology
chemical_list: D000198:Spectinomycin; D013839:Thiamphenicol
vernacular_title: Neisseria gonorrhoea à Pikine (Sénégal): surveillance de la sensibilité aux antibiotiques.