[Occurrence of antigen-antibody complexes in the clinic].
We have analyzed 3,671 out of 16,000 immune-complex determination for this I.U.I.S.-Symposium in St. Georgen/Längsee, Carinthia, Austria. Patients came from various parts of Austria suffering from various inflammatory, regressive, autoimmune diseases or immunodeficiency. After extended trials of standardization with various complement tests and biological assays we have studied systematically PEG-precipitation and correlated with the clinic and biopsy in representative cases. Our experience showed, that complement assays may be sensitive to storage, shipping and sampling errors and have to be considered with this respect. Physical methods give additional informations to the diagnosis, prognosis and course of some diseases and are very useful for the clinical routine laboratory with the reservation, that the precipitated material consists of inflammatory and other denatured proteins but immunecomplexes. Precipitated materials is easily accessible to further biochemical identification.
Tilz
G P
GP
Medizinischen Klinik, Universität Graz.
Becker
H
H
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis; D015922:Complement C1q / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007105:Immune Complex Diseases / Q000175:diagnosis* / Q000276:immunology; D007239:Infections / Q000175:diagnosis; D007249:Inflammation / Q000175:diagnosis
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D015922:Complement C1q
Vorkommen von Antigen-Antikörper-Komplexen in der Klinik.