title: [In vitro activity of imipenem against hospital bacteria].
abstract: Imipenem proved highly active against Enterobacteriaceae: the different bacterial groups exhibited similar mode MICs (0.12 to 0.25 micrograms/ml), except for Serratia (0.25-0.5 micrograms/ml), Proteus mirabilis (0.5 micrograms/ml), indole-positive Proteus (2 micrograms/ml) and Providencia (1 mu/ml). The MICs of cefotaxime-resistant strains (cephalosporinase hyperproducing or very broad spectrum betalactamase producing) were within the susceptibility range. Imipenem also exhibited satisfactory activity against Pseudomonas aeruginosa (mode MIC 1-2 micrograms/ml), although resistant strains by decrease of permeability were observed, and against Acinetobacter (mode MIC 0.25-0.5 micrograms/ml). The MICs ranged from 0.03 to 4 micrograms/ml (mode MIC 0.5) for Haemophilus and from 0.25 to 1 micrograms/ml for Neisseria gonorrhoeae, regardless of the betalactamase producing status. The MICs for N. meningitidis were less than 0.06 micrograms/ml. Methicillin-susceptible staphylococci had low MICs ranging from 0.008 to 0.5 micrograms/ml (mode MIC 0.016). The MICs for methicillin-resistant strains varied widely from 0.016 to 64 micrograms/ml and were higher after incubation at 30 degrees C. Streptococci and pneumococci were highly susceptible (usually 0.008 to 0.03 micrograms/ml). The MICs for enterococci varied from 0.12 to 32 micrograms/ml (mode MIC 1-2). With the exception of Clostridium difficile, anaerobic bacteria were inhibited by concentrations lower than 1 (mode MIC 0.06 for C. Perfringens and 0.03 for Bacteroides fragilis).
authors: Service de bactériologie, Hôpital Henri-Mondor, Créteil.
authors: C J
authors: CJ
authors: Soussy
authors: J
authors: J
authors: Duval
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D003428:Cross Infection / Q000382:microbiology* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology*; D066298:In Vitro Techniques; D011549:Pseudomonas / Q000187:drug effects*
chemical_list: D015378:Imipenem
vernacular_title: Activité in vitro de l'imipénème sur les bactéries hospitalières.