T cell-dependent immunodepression in vivo in Schistosoma mansoni infected patients.
T-cell function was evaluated in 29 patients with either hepatointestinal or hepatosplenic schistosomiasis by intradermal tests to recall antigens. Immunodepression was detected in 26% of the subjects with hepatointestinal schistosomiasis and in 50% of those with the hepatosplenic form. Cellular immunodepression was related to worm load and spleen size. This non specific T-cell immunodepression may represent a serious constraint to the elimination of intracellular pathogens both in hepatosplenic or hepatointestinal schistosomiasis.
Muniz-Junqueira
M I
MI
Medicina Tropical e Nutrição, Faculdade de Ciências da Saúde, Universidade de Brasília.
Tosta
C E
CE
Prata
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D008109:Liver Diseases, Parasitic / Q000276:immunology*; D008297:Male; D012555:Schistosomiasis mansoni / Q000276:immunology*; D013158:Splenic Diseases / Q000276:immunology* / Q000469:parasitology; D013601:T-Lymphocytes / Q000276:immunology*