Some extrathyroid regulatory mechanisms' aspects in thyroid humoral state at the delivery.
Thyroid function parameters (triiodothyronine, thyroxine, reverse triiodothyronine, thyroid stimulating hormone, thyroglobulin) and thyroid binding globulin (TBG) were determined in sera of 64 women who had carried a normal pregnancy and delivered at term, as well as in sera of their newborns. Obtained results were compared to the findings of the same parameters in 28 women who delivered at term, but had been receiving gestanges 1 to 5 months prior to the delivery, and in their babies. In both groups, serum triiodothyronine (T3) levels were normal both in mothers and in their babies. Foetal serum reverse triiodothyronine (rT3) levels were higher (1.58 +/- 0.14, means +/- SEM) as compared to serum levels (0.36 +/- 0.04) of the mothers treated with gestagens; similar results were obtained in the mothers with normal pregnancy (0.41 +/- 0.03) and their babies (1.65 +/- 0.15, means +/- SEM). In 13 out of 64 (20%) women with normal pregnancy serum thyroxine (T4) was elevated in delivery at term, with no impact on the clinical course. Of 28 women who were treated with gestagens for 1 to 5 months only 4 had elevated serum T4 on the delivery. Using gestagens, according to our results, contributes to an increase of the newborn TBG levels (27.00 +/- 2.65; means +/- SEM) in a significant way (p less than 1.001) as compared to TBG of the newborn delivered after a normal pregnancy (21.40 +/- 2.55).
Djurica
S
S
Internal Clinic of Zvezdara Clinical Hospital Centre Belgrade, Yugoslavia.
Cirović
M
M
Lukić
B
B
Gregorić
G
G
Tasovac-Ponomarev
D
D
D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric; D010197:Pancuronium / Q000031:analogs & derivatives / Q000494:pharmacology; D011247:Pregnancy; D011863:Radioimmunoassay; D013961:Thyroid Gland / Q000187:drug effects; D013963:Thyroid Hormones / Q000097:blood*
D013963:Thyroid Hormones; D010197:Pancuronium; C003549:dacuronium