Effect of tetragastrin on azaserine-induced carcinogenesis in rat pancreas.
The effect of tetragastrin on pancreatic tumors induced by azaserine was investigated in Wistar rats. Rats were given 25 weekly injections of 10 mg/kg body weight of azaserine and 1 mg/kg body weight of tetragastrin as a suspension in olive oil every other day. Carcinogen-induced pancreatic lesions were examined by histochemical techniques, and were classified as ATPase-positive or ATPase-negative. In week 62, quantitative histological analysis showed that prolonged administration of tetragastrin had little or no influence on the number and size of the carcinogen-induced pancreatic lesions, although it caused significantly increased cell proliferation, indicated by a greater labelling index of the pancreatic acinar cells.
Tatsuta
M
M
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Iishi
H
H
Baba
M
M
Nakaizumi
A
A
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D001377:Azaserine; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005755:Gastrins / Q000494:pharmacology*; D008297:Male; D008940:Mitotic Index; D009929:Organ Size / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D013758:Tetragastrin; D001377:Azaserine; D000251:Adenosine Triphosphatases