Selective death of T cell receptor gamma/delta+ intraepithelial lymphocytes by apoptosis.
In mice, the majority of T cells expressing the gamma/delta T cell receptor (TcR) are found at mucosal surfaces, especially the intestinal epithelium. Here we show that in vitro, the majority of TcR gamma/delta+ intraepithelial lymphocytes, but not TcR alpha/beta+ intraepithelial lymphocytes, undergo rapid and selective programmed cell death by apoptosis.
Viney
J L
JL
Department of Paediatric Gastroenterology, St. Bartholomews Hospital, London, GB.
MacDonald
T T
TT
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D017252:CD3 Complex; D002470:Cell Survival; D002478:Cells, Cultured; D004249:DNA Damage; D004847:Epithelial Cells; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000145:classification / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000166:cytology*; D013696:Temperature
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell