title: Taking the laparoscope to the laboratory for ventilatory research.
abstract: Chronic ventilatory support by phrenic nerve stimulation has been accomplished, but potential permanent phrenic nerve injury has limited its therapeutic use. Prior work from the authors' laboratory has demonstrated that direct muscle stimulation can be safely performed for prolonged periods. Thus, in 1983, a laparoscopic technique was devised for the direct implantation of diaphragm pacing electrodes in the canine. During the subsequent four years, 16 animals (10 acute and 6 chronic) have undergone diaphragm pacing. Under general anesthesia, diaphragm pacing electrodes loaded into 19-gauge needles were implanted under direct laparoscopic visualization in both hemidiaphragms. In each animal, tidal volume, transdiaphragmatic pressure, arterial blood gas, impedence, cardiac activation, and histology of electrode placement site have been evaluated. Chronically paced animals were subjected to daily 8- to 24-hr per day pacing. The longest paced animal has been 179 days with continuous 24-hour per day pacing. In both acute and chronic experiments, maximal evoked tidal volume has approached 400 per cent of resting tidal volume. Cardiac ectopy has not occurred. This work has demonstrated the safety and feasibility of direct muscular diaphragm activation using the laparoscope. It has provided the basis for embarking upon a clinical study of this modality as a method of chronic ventilatory support. The laparoscopic technique of electrode placement may have a variety of other potential applications.
authors: Department of Surgery, Case Western Reserve University, Cleveland, Ohio.
authors: T A
authors: TA
authors: Stellato
authors: D K
authors: DK
authors: Peterson
authors: P
authors: P
authors: Buehner
authors: M L
authors: ML
authors: Nochomovitz
authors: J T
authors: JT
authors: Mortimer
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000502:physiology*; D004285:Dogs; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004594:Electrophysiology; D010535:Laparoscopy / Q000379:methods*; D012119:Respiration / Q000502:physiology*