[Effect of citric acid and calcium on the bioavailability of orally-administered oxytetracycline in piglets].
The bioavailability of orally given oxytetracycline in dependence on calcium (0.7% and 1.4% calcium, respectively) and citric acid content in feed was examined in piglets (9.9 +/- 0.9 kg body weight). In the first trial no citric acid was added to the two feeds, in the second trial 1.5% citric acid was added. In both trials each piglet received an i/v-injection of oxytetracycline (dosage 10 mg/kg body weight) and an oral dose of oxytetracycline (40 mg/kg body weight). The blood samples, taken in definite time intervals, were analysed by a microbiological assay. With these results the kinetic parameters and the bioavailability were calculated. The results of the i/v-trials were identical. The kinetic parameters C1 = 14.91 micrograms/ml, lambda 1 = 3.46 h-1, Cz = 7.49 micrograms/ml and lambda z = 0.19 h-1 describe the graph after i/v-application. The calcium content of the feed had no significant influence on the kinetic parameters after p/o-application, but the piglets receiving citric acid showed a significant higher maximum concentration (Cmax). The bioavailability of orally given oxytetracycline was significantly (26%) increased by the citric acid content. In spite of the citric acid the bioavailability only came to 4.9%.
Wanner
M
M
Institut für Veterinär-Physiologie, Universität Zürich.
Nietlispach
G
G
Sutter
H M
HM
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000494:pharmacology*; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013047:Specific Pathogen-Free Organisms; D013552:Swine / Q000378:metabolism*
D002951:Citrates; D019343:Citric Acid; D002118:Calcium; D010118:Oxytetracycline
Einfluss von Citronensäure und Calcium auf die Bioverfügbarkeit oral verabreichten Oxytetracyclins beim Ferkel.