Histopathology of the spleen in non-Hodgkin's lymphoma.
The human spleen has several different lymphoid compartments, which may be preferentially involved by non-Hodgkin's lymphomas. Low grade B-cell lymphomas tend to involve the compartments of the spleen where their normal physiological counterparts are found. High grade B-cell lymphomas grow more destructively without respecting lymphoid compartments. T-cell lymphomas involve mainly the T-cell areas, but may also involve follicles and the red pulp. Since non-Hodgkin's lymphomas can be regarded as clonal proliferations of lymphocytes frozen at a stage in differentiation, one possible conclusion is that low grade lymphomas are governed by normal homing mechanisms. High grade lymphomas may have lost their homing properties.
van Krieken
J H
JH
Department of Pathology, University Hospital Leiden, The Netherlands.
D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000473:pathology*; D013154:Spleen / Q000473:pathology*