An assessment of left ventricular systolic function in pressure and volume overload heart with two shell compartment model of ellipsoid revolution.
Left ventricular (LV) midwall mechanics were evaluated in normal, pressure overload due to hypertension, and volume overload hearts due to aortic (AR) and mitral regurgitations (MR) using a 2 shell compartment model of ellipsoid revolution. While ejection fraction (EF) was in the normal range, midwall fractional shortening (MFS) was depressed with low end-diastolic and end-systolic stress in hypertrophied hearts with pressure overload. Not only LV volumes but also LV systolic pressure and wall thickness were increased in AR. LV end-diastolic pressure was elevated, and EF and MFS were reduced in patients with AR and congestive heart failure (CHF). In patients with MR and CHF, pulmonary capillary wedge pressure was elevated, LV volumes were enlarged and end-systolic stress was high, but LV wall thickness and MFS remained in the normal range. It is concluded from this observation that: 1) myocardial contractility is already depressed with normal systolic function in hypertrophied ventricle with pressure overload. 2) AR can be considered to be the disease of both pressure and volume overload, and symptoms of CHF are the result of depressed myocardial contractility. 3) MR is the disease of pure volume overload. Myocardial contractility is well preserved even with the presence of severe CHF in MR.
Hirota
Y
Y
Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan.
Shimizu
G
G
Ishii
K
K
Kusukawa
J
J
Kita
Y
Y
Kawamura
K
K
D000328:Adult; D000704:Analysis of Variance; D001022:Aortic Valve Insufficiency / Q000150:complications; D001794:Blood Pressure; D002306:Cardiac Volume; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications; D008955:Models, Cardiovascular; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left