[The characteristics of the phenotype and lymphocyte function in patients with a mucosal lesion of the large intestine].
The results of studies of functional activity of lymphocyte subpopulations: theophylline-sensitive (thphs-1) and theophylline-resistant (thphr-1), separated from peripheral blood of healthy people and patients with nonspecific ulcerative colitis (NUC) are represented in this paper. The evaluation of the separated subpopulations was performed by local xenogeneic graft-VS-host reaction, study of distribution of nonspecific esterase in cells and determination of relative amount of Fc gamma-R positive lymphocytes among thphs-1 and thphr-1. It was established that lymphocytes of patients with NUC had an alternative form of action on development of xenogeneic graft-VS-host reaction in contrast with cells of donors, that is inhibited the reaction. Among thphr-1 patients with NUC the amount of EC gamma-R cells and cells with diffuse distribution of enzyme with small degree activity was positively increased.
Burmistrova
A L
AL
Ebert
L Ia
LIa
D000818:Animals; D003093:Colitis, Ulcerative / Q000276:immunology*; D004351:Drug Resistance / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D010641:Phenotype; D011961:Receptors, Fc / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000637:transplantation; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013806:Theophylline / Q000494:pharmacology; D014183:Transplantation, Heterologous
D011961:Receptors, Fc; D013806:Theophylline
Osobennosti fenotipa i funktsii limfotsitov bol'nykh s porazheniem slizistoĭ obolochki tolstoĭ kishki.