[Clinical and immunologic test of the activity of a polymicrobial vaccine in patients with chronic bronchitis during a flare-up].
The authors evaluated the effect of an orally administered polymicrobial vaccine in a group of chronic bronchitis patients in order to assess its efficacy in preventing recurrent infections and as adjuvants during minor acute episodes. Compared to the control group, vaccinated patients had 1) a reduced number of flare-ups, and these were less severe and symptoms were improved; II) lymphocyte phenotype was not altered in any of the patients but nevertheless the response to skin tests for delayed sensitivity was improved in the vaccinated patients only; III) more rapid symptomatic improvement of flare-ups. The authors stress the improvement of cell-mediated lymphocyte function as a result of vaccination, probably due to macrophage activation and with resulting improvement of the clinical course of the bronchial disorder.
Zanasi
A
A
Istituto di Fiopatologia Respiratoria, Università degli Studi di Bologna.
Tumietto
F
F
Costigliola
P
P
Ricchi
E
E
Cacaci
C
C
Cappelletti
O
O
De Bernardi
M
M
D000328:Adult; D000368:Aged; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D001991:Bronchitis / Q000276:immunology / Q000628:therapy*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D012882:Skin Tests; D013211:Staphylococcus aureus / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
D001428:Bacterial Vaccines
Verifica clinica ed immunologica dell'attività di un vaccino polimicrobico in pazienti affetti da bronchite cronica in fase di riacutizzazione.