Comparison of alpha beta and gamma delta expressing CD3+ acute lymphoblastic leukemias.
Analysis of 267 consecutive cases of acute lymphoblastic leukemias (ALL) showed that 67 (25%) of cases were of T cell lineage and that 21/67 (31%) expressed the CD3 antigen. Of 13 CD3+ T-ALLs, 7 expressed gamma delta and 6 alpha beta. Comparison of these 2 groups showed differences in clinical and immunophenotypic parameters. The patterns of rearrangement of TCR gamma and TCR delta genes and their junctional nucleotide sequences also differed between the 2 groups. Further analysis of these patients may allow the distinction of subpopulations of ALL which merit altered management.
Macintyre
E A
EA
Molecular Hematology Laboratory, Saint-Louis Hospital, Paris, France.
Salloum
E
E
Sigaux
F
F
D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001483:Base Sequence; D017252:CD3 Complex; D002648:Child; D002675:Child, Preschool; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000032:analysis* / Q000276:immunology*; D012189:Retrospective Studies
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell