title: Rhythms in the ovulatory cycle. 3rd: Cortisol and dehydroepiandrosterone sulphate (DHEA-S).
abstract: The circadian profiles of cortisol and dehydroepiandrosterone sulphate (DHEA-S) were analyzed in a homogeneous group of 15 young normally cycling women, at 4 times of the menstrual cycle: early follicular (EF), late follicular (LF), early luteal (EL) and late luteal (LL) stages. The circatrigintan variations of the same hormones were also evaluated. Population-mean cosinor analysis allowed the demonstration of a highly significant circadian periodicity for both variables in any of the 4 stages of the menstrual cycle; on the other hand, the same computation failed to demonstrate a significant circatrigintan periodicity. In each of the stages considered, the circadian acrophase of DHEA-S was delayed in comparison to that of cortisol, being located in the early afternoon hours. The demonstration of a clear-cut circadian oscillation in serum DHEA-S prompts studies on possible chrono-abnormalities of the steroid production in women with hyperandrogenic diseases.
authors: Cattedra di Cronobiologia, Facoltà di Medicina e Chirurgia, Univerità degli Studi di Milano, Italy.
authors: F
authors: F
authors: Carandente
authors: A
authors: A
authors: Angeli
authors: G B
authors: GB
authors: Candiani
authors: P G
authors: PG
authors: Crosignani
authors: F
authors: F
authors: Dammacco
authors: L
authors: L
authors: De Cecco
authors: P
authors: P
authors: Marrama
authors: M
authors: M
authors: Massobrio
authors: L
authors: L
authors: Martini
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008597:Menstrual Cycle / Q000502:physiology*; D011863:Radioimmunoassay
chemical_list: D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone