A new antipseudomonal cephalosporin CP6162 and its congeners.
The synthesis and biological activity of a series of 3-[2-(5-hydroxy-4-pyridon-2-yl)ethenyl]cephalosporin derivatives are described. They showed very potent activity against Gram-negative bacteria, especially Pseudomonas aeruginosa. (6R, 7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2 -(1-carboxy-1-methyl)-ethoxyiminoacetamido]-3-[(Z)-2-(1,5-dihydrox y-4- pyridon-2-yl)ethenyl]ceph-3-em-4-carboxylic acid, CP6162 (8e), was selected for further evaluation as antipseudomonal chemotherapeutic agent.
Iwamatsu
K
K
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Atsumi
K
K
Sakagami
K
K
Ogino
H
H
Yoshida
T
T
Tsuruoka
T
T
Shibahara
S
S
Inouye
S
S
Kondo
S
S
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000737:chemistry / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013237:Stereoisomerism
D002511:Cephalosporins; C066804:CP 6162