Significance and validity of a shortened lead chelation test.
We evaluated the chelation test in 38 subjects exposed to lead or with suspected lead exposure, comparing the values of lead excretion at the 3rd h (PbU EDTA/3-h) and at the 24th h (PbU EDTA/24-h) after EDTA administration. Good correlation exists between PbU EDTA/3-h and PbU EDTA/24-h (r = .86) and between them and the main biological indicators of dose and effect of lead. When a second chelation test was performed in 15 subjects, a slightly better r coefficient (.93) was observed between the two tests, without reaching statistical significance. It seems difficult, in terms of the type of exposure that we considered, to use the 3-h test, on an individual basis, to predict the PbU EDTA/24-h values.
Apostoli
P
P
Institute of Occupational Health, University of Brescia, Italy.
Porru
S
S
Duca
P
P
Ferioli
A
A
Alessio
L
L
D000328:Adult; D001806:Blood Urea Nitrogen; D002614:Chelating Agents; D015913:Chelation Therapy; D003404:Creatinine / Q000097:blood; D004492:Edetic Acid / Q000627:therapeutic use; D006801:Humans; D007854:Lead; D007855:Lead Poisoning / Q000097:blood / Q000628:therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012044:Regression Analysis; D012680:Sensitivity and Specificity
D002614:Chelating Agents; D007854:Lead; D004492:Edetic Acid; D003404:Creatinine