Oxypurinol protects normothermic ischemic hearts.
Rabbit hearts were mounted on a Langendorff apparatus and after measurement of baseline hemodynamic function exposed to 30 minutes normothermic arrest. Hearts were reperfused at 37 degrees C with buffer solution containing oxypurinol in different concentration: group II (0.01 mM), group III (0.1 mM), group IV (1 mM). Group I did not receive active drug and served as control. Each group consisted of eight hearts. After reperfusion, hemodynamic function was again measured and compared to baseline. Groups III and IV showed significantly less deterioration (p less than 0.05) than the control, while group II was better than the control, but in general differences were nonsignificant. We conclude that oxypurinol ameliorates ischemic cardiac damage following normothermic cardiac arrest. The beneficial effect of oxypurinol is most likely due to the drug's scavenging effect of oxygen-free radicals.
Bergsland
J
J
Department of Surgery, State University of New York, Buffalo.
Lobalsamo
L
L
Lajos
P S
PS
Feldman
M J
MJ
Vanwylen
D G
DG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D006324:Heart Arrest, Induced; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000032:analysis; D007288:Inosine / Q000032:analysis; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D010117:Oxypurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D016277:Ventricular Function, Left / Q000187:drug effects; D019820:Xanthine; D014970:Xanthines / Q000032:analysis
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D019271:Hypoxanthine; D007288:Inosine; D010117:Oxypurinol