Albumin decrement in depression and cholesterol decrement in mania.
Within all psychiatric inpatients over a 4-year period, on admission depressives showed serum albumin 5.4% lower (P less than 0.001) than non-psychiatric controls. Similarly, manics showed cholesterol 10% lower (P less than 0.0005) and serum calcium/protein ratio 2.2% higher (P less than 0.05) than controls. These deviations suggest a tendency towards dietary aberrations in these patients of potential medical significance. These tests had shown the most distinct variation with diagnosis on split-half discriminant function analysis of routine chemistry and hematology tests of 107 patients with mania, 132 with depression, 67 with schizophrenia, 18 with schizoaffective illness, and 83 non-psychiatric controls admitted for elective surgery.
Swartz
C M
CM
Department of Psychiatry, UHS/Chicago Medical School, IL.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000097:blood; D012559:Schizophrenia / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism*
D001798:Blood Proteins; D012709:Serum Albumin; D002784:Cholesterol; D002118:Calcium