[Comparison of the activities of the hepatic and renal mixed function oxidase (MFO) systems in rats during different postnatal periods of life].
In an effort to investigate the diminished capacity of young and old individuals to metabolize certain drugs--in this paper--the effect of different age on the concentrations of the hepatic and renal mixed function oxidase systems of rats was studied. Microsomal cytochrome P-450 concentration and NADH-cytochrome b5 reductase activity were increased both in liver (to 1-2 months) and in kidney (to 2-4 months), and then were decreased. Aging not changed concentrations of hepatic and renal cytochrome b5 after 2 months of life. NADPH-cytochrome P-450 reductase activities were decreased in both organs of young rats and were increased in old rats livers and decreased in old rats kidneys.
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II Katedry Histologii i Embriologii, Slaskiej Akademii Medycznej w Katowicach.
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D000367:Age Factors; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D042966:Cytochrome-B(5) Reductase; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D003579:Cytochrome Reductases; D042966:Cytochrome-B(5) Reductase; D009251:NADPH-Ferrihemoprotein Reductase
Porównanie aktywności watrobowego i nerkowego układu oksydaz o funkcji mieszanej (MFO) w róznych okresach zycia pozapłodowego szczurów.