[Postinfection and postvaccinal antianthrax immunity in human subjects].
Antibodies to Bacillus anthracis protective antigen (PA) and to the lethal factor (LF) of B. anthracis exotoxin in the blood sera of anthrax patients and of subjects with a history of the disease, as well as of persons immunized with STI live vaccine, were studied by the heterogeneous enzyme immunoassay. In 1-6 years after convalescence the levels of anti-PA and anti-LF antibodies (at 75% and 96% detection rates respectively) were higher than on weeks 1-4 from the onset of the disease. In persons having had anthrax antibodies belonged mainly to IgG, and the anti-LF antibody level was higher than the anti-PA antibody level. In persons immunized with STI vaccine the detection rate of antibodies somewhat increased in 2-7 months after immunization, reaching, on the average, 72%, the antibody levels after primary immunization and regular annual booster immunization being similar. In 1-2 years after primary (booster) immunization the isolation rate of antibodies decreases to 21%. Specific features of postinfectious and postvaccinal immunity to anthrax and problems of retrospective diagnosis of this disease are discussed.
Abalakin
V A
VA
Dzhabirov
Sh S
ShS
Kalita
V A
VA
Kuttugulov
V K
VK
Amireev
S A
SA
Knop
A G
AG
Cherkasskiĭ
B L
BL
D000328:Adult; D000382:Agricultural Workers' Diseases / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control; D000881:Anthrax / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control; D000907:Antibodies, Bacterial / Q000097:blood; D001408:Bacillus anthracis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007117:Immunization, Secondary; D007623:Kazakhstan; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Postinfektsionnyĭ i postvaktsinal'nyĭ protivosibireiazvennyĭ immunitet u liudeĭ.