A new method for conservative renal surgery--experimental and first clinical results.
So far two methods for prolonging the tolerance of renal ischemia are available: 1) surface cooling with crushed ice and 2) perfusion cooling with an extracellular-like solution. Both methods use only the principle of reducing metabolism through cooling. While rewarming during surgery the ischemic protection is lost, or the kidney must be cooled once again. Therefore, a new preservation solution should reduce energy consumption due to its composition in addition to cooling. For open heart surgery, the HTK solution by Bretschneider is already used clinically. In 71 dog kidney experiments, the ischemic time kidneys could tolerate was prolonged by this solution from 15 to 120 min at 35 degrees C and from 45 to 360 min at 25 degrees C. After 2 h of ischemia at 30 degrees C glomerular filtration rate was about 20 ml/min.100gww within 3 h of reperfusion. After six postoperative days the filtration rate was 40 ml/min.100 gww. No ischemic damage could be recognized by histological investigations. The clinical effectiveness of this method was shown in 7 clinical applications. Ischemic duration lasted up to 113 min, and blood creatinine was between 0.8 and 2.4 mg% at the 6th postoperative day. Use of this preservation technique thus leads to improved kidney function immediately following operation. Longer ischemia can be tolerated by a kidney thus protected, and using this technique excellent visibility can be achieved during intrarenal surgery, simplifying, for example, tumor extirpation.
Kallerhoff
M
M
Department of Urology, University of Göttingen.
Blech
M
M
Götz
L
L
Kehrer
G
G
Bretschneider
H J
HJ
Helmchen
U
U
Ringert
R H
RH
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000601:surgery; D002314:Cardioplegic Solutions; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D005947:Glucose; D006391:Hemangioma / Q000601:surgery; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006982:Hypertonic Solutions; D007668:Kidney / Q000502:physiology / Q000601:surgery*; D007669:Kidney Calculi / Q000601:surgery; D007680:Kidney Neoplasms / Q000601:surgery; D008067:Lipoma / Q000601:surgery; D008297:Male; D008353:Mannitol; D010477:Perfusion; D011189:Potassium Chloride; D011343:Procaine
C039984:Bretschneider cardioplegic solution; D002314:Cardioplegic Solutions; D006982:Hypertonic Solutions; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D005947:Glucose