The antihypertensive agent cicletanine reverses vascular hyperreactivity to noradrenaline and cardiac hypertrophy in DOCA-salt rats.
Cicletanine, when given p.o. either acutely or subchronically, was found to produce a clear-cut antihypertensive effect in the deoxycorticosterone salt experimental rat model. This compound was able to reverse high blood pressure, even at doses deprived of diuretic effect. Subchronic treatment (30 mg/kg, p.o.; 14 days) with cicletanine reduced the enhanced contractile response to noradrenaline in deoxycorticosterone salt rat aortic strips and reversed the cardiac hypertrophy in these animals. The antihypertensive effect after long-term treatment with cicletanine in deoxycorticosterone salt rats appears to be related to an antagonism of the elevated sympathetic drive to the vascular smooth muscle.
Castro
A
A
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Parra
L
L
Alsasua
A
A
Fuentes
J A
JA
D000315:Adrenalectomy; D000818:Animals; D000959:Antihypertensive Agents; D001013:Aorta, Thoracic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000503:physiopathology*; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D003900:Desoxycorticosterone; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009392:Nephrectomy; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011725:Pyridines; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D004232:Diuretics; D011725:Pyridines; D003900:Desoxycorticosterone; C038068:cicletanine; D009638:Norepinephrine