[A double-blind study comparing the clinical efficacy of the preparation F-117 (hidrosmin) versus diosmin in the treatment of patients with peripheral venous disorders].
A controlled double-blind clinical trial was performed comparing therapeutic efficacy of hidrosmin versus diosmin in patients suffering from chronic venous insufficiency with varicose symptomatology in the inferior limbs. Ten patients were treated with hidrosmin and other 10 with diosmin randomly. The controls carried out during the trial were as follows; basal control before the beginning of the trial and therapeutic controls on days 15, 30, 60 and 90 of the study. With that aim clinical examinations and different explorations were performed: physical exam, phlebography, electrocardiogram, ophthalmological examination and biochemical analyses (hemogram, globular sedimentation rate, platelet counts, etc.). The clinical therapeutic efficacy of hidrosmin in the treatment of chronic venous insufficiency of inferior limbs was superior to the diosmin in most of the studied parameters even though a lower posology was employed. From a clinical point of view the clinical improvement in the subjective symptomatology (heaviness, local tenderness, cramps, paresthesias, etc.) was very superior to the one obtained with the objective signs (phlebography, skin trophism, evolution of the edema, etc.). No significative adverse reactions appeared.
Honorato Pérez
J
J
Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona.
Arcas Meca
R
R
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004145:Diosmin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004311:Double-Blind Method; D004361:Drug Tolerance; D004487:Edema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011186:Postphlebitic Syndrome / Q000188:drug therapy*; D014648:Varicose Veins / Q000188:drug therapy*; D014689:Venous Insufficiency / Q000188:drug therapy*
C071047:hidrosmin; D004145:Diosmin
Estudio doble ciego comparando la eficacia clínica del preparado F-117 (hidrosmina) versus diosmina en el tratamiento de pacientes con trastornos venosos periféricos.