Lead intoxication in an anuric patient: management by intraperitoneal EDTA.
Treatment of lead intoxication with intravenous ethylene-diamine-tetra-acetic acid (EDTA) depends on the urinary excretion of chelated lead. This route of excretion was absent in a 48-year-old patient with childhood lead exposure and end stage renal failure who developed encephalopathy and a rapidly progressive neuropathy thought to be due to acute lead intoxication. Diagnosis was confirmed by lead chelation with EDTA and neurophysiological studies. EDTA was added by the patient to her chronic ambulatory peritoneal dialysis (CAPD) fluid each week and chelated lead excreted in the dialysate. Intraperitoneal administration of EDTA was 70% as efficient in removing lead as intravenous administration. Four months of home chelation therapy was associated with resolution of the encephalopathy but no improvement in the peripheral neuropathy.
Roger
S D
SD
Westmead Hospital, Sydney, NSW, Australia.
Crimmins
D
D
Yiannikas
C
C
Harris
D C
DC
D001002:Anuria / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D002908:Chronic Disease; D004492:Edetic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy*; D007855:Lead Poisoning / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory
D004492:Edetic Acid