[The expression of Fc gamma receptors on the surface of macrophages activated by a vaccinal strain of Yersinia pestis].
The expression of Fc gamma R on the surface of macrophages in the process of antiplague immunity formation is analyzed. The stud is performed on the alveolar and peritoneal macrophages obtained from intact and immunized guinea pigs in different periods after vaccination (the 1st, 7th, 14th and 21st day). It is established that during the formation of the antiplague immunity there occurs activation of macrophages which is accompanied by an increase of the Fc gamma R expression on the outer surface of the membrane both of peritoneal and alveolar macrophages and the pattern of response of these cells to the interaction with the vaccine strain of the plague microbe changes. The Fc gamma R expression heterogeneity of certain macrophage populations is revealed both in an intact and in immune organism as well as different pattern of the intact alveolar and peritoneal macrophage response during the interaction with the vaccine strain of the antiplague microbe. These differences are levelled in the process of the antiplague immunity formation.
Vasil'eva
G I
GI
Tkachenko
L N
LN
Doroshenko
E P
EP
Gamleshko
Kh P
KhP
Balatskaia
T A
TA
D000818:Animals; D000943:Antigens, Differentiation / Q000032:analysis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000032:analysis / Q000276:immunology*; D010930:Plague / Q000276:immunology / Q000517:prevention & control; D011961:Receptors, Fc / Q000032:analysis / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation; D013499:Surface Properties; D013997:Time Factors; D014774:Virulence / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology* / Q000472:pathogenicity
D000943:Antigens, Differentiation; D001428:Bacterial Vaccines; D011961:Receptors, Fc; D017452:Receptors, IgG
Ekspressiia Fc gamma-retseptorov na poverkhnosti makrofagov, aktivirovannykh vaktsinnym shtammom chumnogo mikroba.