[HLA-associated predisposition to dilated cardiomyopathy].
HLA-antigens grade I and II were studied by tissue typing in 60 Russians and 40 Georgians suffering from dilated cardiomyopathy (DCMP), and 40 Georgians with virus myocarditis. 267 test-donors Russians and 579 Georgians served as control. Markers of DCMP predisposition were found different for Russians and Georgians: DR4 (relative risk 2.96) and A11 (RR = 3.07), R12 (RR = 5.5), respectively. Georgians have a marker of resistance to DCMP--B35 (RR = 0.15). Antigen B12 marks a severe DCMP course in Georgians. Markers of virus myocarditis predisposition were distinct from those of DCMP: A1 (RR = 3.78) and B27 (RR = 3.62). This shows different etiology of the two diseases. The conclusion is made on nonidentical genetic markers of predisposition and resistance to the same disease in various populations.
Polianskaia
I S
IS
Alekseev
L P
LP
Chumburidze
V B
VB
Iurenev
A P
AP
Guniia
M G
MG
Dubov
P B
PB
Dolbin
A G
AG
D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility; D005787:Gene Frequency / Q000235:genetics; D005846:Georgia (Republic); D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D012426:Russia
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015804:HLA-DR4 Antigen
Assotsirovannaia s HLA predraspolozhennost' k dilatatsionnoĭ kardiomiopatii.