[Undesirable drug reactions in simultaneous administration of high-dosage phenobarbital and beta-lactam antibiotics].
The present paper reports on a striking increase in undesirable drug induced reactions during simultaneous administration of high-dosage phenobarbital and beta-lactam antibiotics to children in intensive care. In a 30-month study period, reactions which had to be classified as drug-induced were seen in 24 out of a total of 49 children (mainly exanthematous skin reactions, in some cases severe). The complications were mainly observed in patients receiving a combination of cefotaxime and phenobarbital. Etiologically, a toxic reaction to the combination of hepatically metabolized beta-lactam antibiotics with an enzyme-inducing drug must be considered in addition to the allergenic potential of the individual components.
Harder
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S
Abt. Klinische Pharmakologie, Klinikum der J. W. Goethe Universität, Frankfurt/Main.
Schneider
W
W
Bae
Z U
ZU
Bock
U
U
Zielen
S
S
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002439:Cefotaxime / Q000009:adverse effects; D002648:Child; D003875:Drug Eruptions / Q000209:etiology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D002439:Cefotaxime; D010634:Phenobarbital
Unerwünschte Arzneimittelreaktionen bei gleichzeitiger Gabe von hochdosiertem Phenobarbital und Betalaktam-Antibiotika.