The tumour-localizing properties of porphyrin derivatives.
The tumour-localizing abilities of various kinds of porphyrin derivatives in tumour-bearing hamsters were assessed by nitrogen-pulsed laser spectrofluorometry (N2-PLS). On examination of porphine derivatives (from haemoglobin), it was found that the dimer and acetylated and amidated compounds had a high affinity for tumour tissue; the dimer and hydroxylated compound of phorbine derivatives (from chlorophyll) also showed a high affinity. Furthermore, of the metalloporphines (gallium, zinc and indium complexes), those which contained hydrophilic groups showed a high affinity for tumour tissue; of the metallophorbines (gallium, zinc and indium complexes), those which contained hydrophobic groups showed a high affinity. A correlation was found between the side-chain structure of the porphyrins and metalloporphyrins and their affinity for tumour tissue.
Nakajima
S
S
Department of Surgery, Asahikawa Medical College, Japan.
Hayashi
H
H
Omote
Y
Y
Yamazaki
Y
Y
Hirata
S
S
Maeda
T
T
Kubo
Y
Y
Takemura
T
T
Kakiuchi
Y
Y
Shindo
Y
Y
D000818:Animals; D006224:Cricetinae; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism*; D010778:Photochemotherapy; D011166:Porphyrins / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D011166:Porphyrins