title: Impaired utilization of exogenous amino acids after surgery for subarachnoid haemorrhage.
abstract: We studied the metabolic response to acute aneurysm surgery and its modification by parenteral nutrition. Forty-eight patients receiving perioperative corticosteroid treatment were randomly assigned to receive glucose alone (7.2 kcal/day, D5W + C), glucose and a conventional amino acid solution (7.2 kcal/day and 0.15 gN/day, CAA + C) or glucose and branched chain amino acid enriched solution (7.2 kcal/day and 0.14 gN/day, BCAA + C). Twenty patients without corticosteroid treatment received either glucose alone (7.2 kcal/day, D5W) or glucose and a conventional amino acid solution (7.2 kcal/day and 0.14 gN/day, CAA). Poor nitrogen utilization was indicated by strongly negative nitrogen balance in all groups and a failure of the infused amino acids to improve nitrogen balance. (Day 0; D5W + C: -9.3 +/- 3.6 g/day and CAA + C: -8.2 +/- 9.7 g/day vs CAA: -2.6 +/- 4.9 g/day, p less than 0.05, Day 1; D5W + C: -14.9 +/- 9 g/day vs CAA: -7.7 +/- 6.5 g/day, p less than 0.05, MANOVA). We conclude that subarachnoid haemorrhage and its surgical treatment induce a catabolic response and impaired utilization of exogenous nitrogen, further amplified by perioperative corticosteroids, which is in sharp contrast to the response to surgery not involving the central nervous system.
authors: Department of Anesthesiology and Intensive Care, Kuopio University Central Hospital, Finland.
authors: K
authors: K
authors: Hersio
authors: M
authors: M
authors: Vapalahti
authors: A
authors: A
authors: Kari
authors: J
authors: J
authors: Takala
authors: J
authors: J
authors: Hernesniemi
authors: A
authors: A
authors: Tapaninaho
authors: M
authors: M
authors: Luukkonen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage* / Q000097:blood; D001806:Blood Urea Nitrogen; D003131:Combined Modality Therapy; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D002532:Intracranial Aneurysm / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000097:blood / Q000628:therapy*; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000601:surgery*
chemical_list: D000305:Adrenal Cortex Hormones; D000597:Amino Acids, Branched-Chain