High-affinity platelet [3H]LSD binding is decreased in panic disorder.
Platelet [3H]LSD binding was measured in 15 patients with panic attacks and 15 controls. The mean (+/- SD) Bmax values of the patients (14.1 +/- 6.3 fmol/mg protein) and of the controls (18.5 +/- 4.7 fmol/mg protein) were significantly different (P less than 0.05, Mann-Whitney U-test). Mean (+/- SD) values of Kd for the patients (0.55 +/- 0.34 nM) and for the controls (0.51 +/- 0.12 nM) were not significantly different (P greater than 0.1, Mann-Whitney U-test). The results are discussed in terms of a serotonergic hypothesis of the aetiology of panic disorders.
Norman
T R
TR
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.
Judd
F K
FK
Staikos
V
V
Burrows
G D
GD
McIntyre
I M
IM
D000328:Adult; D000379:Agoraphobia / Q000097:blood* / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010556:Personality Tests; D011985:Receptors, Serotonin / Q000378:metabolism*; D012737:Sex Factors
C031182:LSD receptor; D011985:Receptors, Serotonin; D008238:Lysergic Acid Diethylamide