[Mechanisms in the modulation of the reactions of immune splenocytes by macroheterocyclic compounds].
The effect of macroheterocyclic compounds possessing immunostimulating properties in vivo on the reactions of the immune splenocytes in vitro has been studied. It has been shown that the cell activity is determined by the medium ionic composition. In the medium with the optimal content of the bivalent cations the azacrown ethers decrease the intensity of the immune splenocytes reactions depending on the dose. In the media of the modified ionic composition the studied compounds in concentration 10 microM activate all the reactions of the spleen cells, in concentration 100 microM they suppress or do not change them.
Filippova
T O
TO
Britva
I E
IE
Golovenko
N Ia
NIa
Popkov
Iu A
IuA
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D004988:Ethers, Cyclic / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects / Q000276:immunology; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects* / Q000276:immunology
D004988:Ethers, Cyclic; D006571:Heterocyclic Compounds
Izuchenie mekhanizmov moduliatsii reaktsiĭ immunnykh splenotsitov makrogeterotsiklicheskimi soedineniiami.