Amino acid--induced insulin release from the perfused rat pancreas. The influence of phenylalanine and tyrosine.
The effects of L or D phenylalanine and L tyrosine on insulin release from the perfused rat pancreas were investigated. It was found that in the presence of D-glucose, all three amino-acids stimulate insulin secretion. After L-Phe had been removed from perfusate in the presence or absence of L-Tyr, the secondary rise of insulin release (an "off response") was noticed. This phenomenon did not follow to either D-Phe or L-Tyr.
Maćkowiak
P
P
Department of Animal Physiology and Biochemistry, Academy of Agriculture, Poznań.
D000818:Animals; D005934:Glucagon / Q000494:pharmacology; D007328:Insulin / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D010649:Phenylalanine / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014443:Tyrosine / Q000494:pharmacology*
D007328:Insulin; D014443:Tyrosine; D010649:Phenylalanine; D005934:Glucagon