Long term effects of a first pregnancy on serum concentrations of dehydroepiandrosterone sulfate and dehydroepiandrosterone.
A previous paper in this journal reported that first pregnancy was followed by a marked decrease in dehydro-epiandrosterone sulfate (DHAS) and dehydroepiandrosterone (DHA) levels. We report here confirmatory observations from cross-sectional measurements in 460 women. In premenopausal subjects (n = 306), the mean DHAS level was 21% lower (P = 0.005) and the mean DHA level was 32% lower (P less than 0.001) in parous than in nulliparous women. Neither DHAS nor DHA was related to parity in postmenopausal women (n = 154).
Key
T J
TJ
Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, United Kingdom.
Pike
M C
MC
Wang
D Y
DY
Moore
J W
JW
D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D010298:Parity
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate