title: [Effects of clonidine on experimental stomach ulcer in rats].
abstract: Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively. Clonidine 2 mg/kg ig tended to accelerate the healing of gastric ulcer induced by acetic acid, and the healing rate was 61%. Clonidine decreased the secretion of gastric acid and pepsin, and increased the release of gastric barrier mucus. These actions may contribute to its protective effect against ulceration.
authors: Department of Physiology, Jiangxi University, Nanchang, China.
authors: G Y
authors: GY
authors: Luo
authors: Y
authors: Y
authors: He
authors: L B
authors: LB
authors: Tu
mesh_terms: D000818:Animals; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D008297:Male; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D010434:Pepsin A; D003000:Clonidine