[ACE-inhibitors: physiologic premises and pharmacologic profiles].
In the present paper the authors review the results of more than ten years' experience with ACE-inhibitors in the therapy of hypertension and congestive heart failure. The importance of tissue rather than serum ACE level for the long-term response to these agents has been mainly stressed. Clinical studies have shown the importance of these agents for the general practitioner in view of both their efficacy and the low incidence of untoward effects. If further studies succeed in showing the extent to which individual mechanisms of action of ACE inhibitors contribute to the overall therapeutic effect it can be expected that it will become possible to synthetize new molecules with more selective action. Considering the hypothesis according to which these agents are also effective for the prevention and management of myocardial infarction and in the management of chronic renal failure, these studies would appear to be particularly urgent.
Marino
A
A
II Facoltà di Medicina e Chirurgia dell'Università di Napoli.
Schettini
G
G
Florio
T
T
Ventra
C
C
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012084:Renin-Angiotensin System / Q000502:physiology*
D000806:Angiotensin-Converting Enzyme Inhibitors
ACE-inibitori: premesse fisiologiche e profili farmacologici.