The use of gonadotropin releasing hormone agonist (GnRHa) in good responders undergoing repeat in vitro fertilization/embryo transfer (IVF/ET).
The use of gonadotropin releasing hormone agonists (Gn-RHa) has been shown to improve the response in patients classified as "poor responders" undergoing ovarian stimulation for in vitro fertilization/embryo transfer (IVF/ET). This study sought to determine whether GnRHa therapy would benefit patients undergoing IVF/ET who had been classified as "good responders" in prior attempts. Twenty-three patients who had completed a prior IVF/ET attempt but who failed to conceive underwent ovarian stimulation using a combination of GnRHa and human menopausal gonadotropin (hMG). Each patient's prior stimulation served as her control and consisted of clomiphene citrate (CC)/hMG in 18 patients and follicle stimulating hormone (FSH) and/or hMG in 5 patients. The numbers of oocytes retrieved, oocytes fertilized, embryos cleaved, and embryos transferred were all significantly greater in cycles treated with GnRHa/hMG compared to control cycles. The clinical pregnancy rate was 39% and the ongoing pregnancy rate was 26% during the cycle when GnRHa pretreatment was utilized. These data suggest that GnRHa therapy is of benefit even to those patients previously classified as "good responders" undergoing ovarian stimulation for IVF/ET.
Segars
J H
JH
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
Hill
G A
GA
Bryan
S H
SH
Herbert
C M
CM
Osteen
K G
KG
Rogers
B J
BJ
Wentz
A C
AC
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002996:Clomiphene / Q000494:pharmacology; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide; D008596:Menotropins / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000502:physiology; D010060:Ovulation / Q000187:drug effects / Q000502:physiology
D000970:Antineoplastic Agents; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide