Cyproterone acetate/ethinyl estradiol in the treatment of acne. A comparative dose-response study of the estrogen component.
The investigators compared 2 mg cyproterone acetate (CPA) in combination with either 0.035 mg or 0.050 mg ethinyl estradiol (EE2) (Diane -35 versus Diane -50) in the treatment of acne. Both formulations of Diane were highly effective in improving acne, even in women who had been refractory to other types of medication. Cycle control with both formulations was excellent and adverse effects were generally mild and confined to the first two cycles of treatment. Mean plasma lipid levels increased with both treatments, yet most individual values remained within normal limits after one year of therapy while the LDL-cholesterol/HDL-cholesterol ratio was stable throughout the study period. Plasma testosterone and DHEA-S levels paralleled the decline in the clinical severity of the acne. There was no loss of clinical effectiveness with Diane -35 and it provided the advantage of a 30% decrease in the amount of estrogen.
Fugère
P
P
Hôpital Saint-Luc, Université de Montréal, Québec, Canada.
Percival-Smith
R K
RK
Lussier-Cacan
S
S
Davignon
J
J
Farquhar
D
D
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D000704:Analysis of Variance; D001053:Apolipoproteins / Q000097:blood; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003534:Cyproterone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D004338:Drug Combinations; D014280:Triglycerides; D013739:Testosterone; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D002784:Cholesterol; D003534:Cyproterone