Study on the expression of HLA-DR antigens, Fc IgG receptors and C3 complement component on lung macrophages in the primary lung carcinoma.
Expression of HLA-DR antigens and Fc IgG receptors as well as C3 complement component, was studied on patients with the primary lung carcinoma and in the control group of nonsmokers and smokers. Macrophages were isolated by broncho-alveolar lavage using bronchofiberoscope. The study was carried out before the treatment, within its course and during remission. The percentage of macrophages with HLA-DR antigens and Fc IgG receptors and C3 complement was observed to diminish before the treatment, after chemo- and radiotherapy as compared to the control. In the course of alpha interferon-treatment and at remission, the expression of HLA-DR antigens on macrophages increased in relation to the remaining groups of patients (p less than or equal to 0.05). The expression of Fc IgG receptors and C3 complement revealed no statistically significant differences. As the findings show the expression of HLA-DR antigens is modulated by interferon and has a tendency to increase in the course of convalescence. On the other hand, the expression of RFc IgG and RC3 complement shows great stabilization in the primary lung carcinoma and undergoes no changes either in the course of treatment or remission.
Szklarz
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Department of Tuberculosis and Lung Diseases, IV Military Hospital, Wrocław.
D000943:Antigens, Differentiation; D003176:Complement C3; D006684:HLA-DR Antigens; D006801:Humans; D007074:Immunoglobulin G; D008175:Lung Neoplasms / Q000276:immunology* / Q000628:therapy; D008264:Macrophages / Q000276:immunology; D011961:Receptors, Fc; D017452:Receptors, IgG
D000943:Antigens, Differentiation; D003176:Complement C3; D006684:HLA-DR Antigens; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG