title: Morphologic changes in cerebral arteries after subarachnoid hemorrhage.
abstract: The premise of this article is that morphologic changes observed in cerebral arteries after subarachnoid hemorrhage play an important role in the pathogenesis of associated ischemic deficits observed in this disorder. Secondly, the arteriopathic response of cerebral arteries to subarachnoid blood is similar in many respects to that observed in systemic vessels under various pathologic conditions, and common pathogenic mechanisms may exist. The data supporting these premises may be summarized as follows: 1. Morphologic changes in human and animal cerebral arteries after subarachnoid hemorrhage are temporally associated with angiographic and clinically significant vasospasm. 2. Profound morphologic changes in cerebral arteries after subarachnoid hemorrhage do not contribute to structural narrowing of the lumen through increases in vessel wall mass. Nevertheless, structural changes may act in concert with contractile mechanisms to alter normal physiologic responses and maintain a narrowed lumen. 3. The agent responsible for arterial narrowing and morphologic changes in cerebral arteries after subarachnoid hemorrhage is contained in the erythrocyte component of whole blood and is most likely hemoglobin. 4. The volume and duration of exposure of subarachnoid blood to the artery appears to be significant in the development of the angiopathic response. 5. Ultrastructural abnormalities in systemic vessels associated with hypertension, atherogenesis, and endothelial damage are similar in many respects to those seen after subarachnoid hemorrhage.
authors: Department of Neurological Surgery, University of Washington School of Medicine, Seattle.
authors: M R
authors: MR
authors: Mayberg
authors: T
authors: T
authors: Okada
authors: D H
authors: DH
authors: Bark
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D013345:Subarachnoid Hemorrhage / Q000473:pathology*