[Acute toxicity of trichloroethylene. Description of a case series at the Autonomous Service of Toxicology of Florence during the 1977-1988 period].
The authors report the number of acute trichloroethylene intoxications admitted to the Toxicological Unit of Florence University from January 1977 to December 1988. The identification of the solvent metabolic pathway allowed to clarify the pathogenesis of hepatorenal dysfunction observed during acute intoxications. Together with gastrointestinal decontamination and cardiac arrhythmia control we have studied the effect of drugs supposed to act as blockers of trichloroethylene metabolism or as inactivators of the hepatotoxic free radical metabolite 2-2(1)-3 trichloroxirane. The prognostic modification related to new therapeutic protocols is reported and discussed.
Pistelli
A
A
Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze.
Masini
E
E
Caramelli
L
L
Botti
P
P
Peruzzi
S
S
Zorn
A M
AM
Mannaioni
P F
PF
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011407:Propane / Q000031:analogs & derivatives; D011480:Protease Inhibitors / Q000506:poisoning; D014241:Trichloroethylene / Q000506:poisoning*
D011480:Protease Inhibitors; D014241:Trichloroethylene; C012076:trielin; D011407:Propane
La tossicità acuta del tricloroetilene. Descrizione della casistica del Servizio Autonomo di Tossicologia di Firenze nel periodo 1977-1988.