Immunotherapy of colon cancer metastases in rats with the immunostimulant OM-89.
In a model of colon cancer in rats the bacterial extract OM-89 was found to have antitumor properties. We have shown that OM-89 induced the complete regression of numerous peritoneal tumor nodules measuring 1-5 mm in 46% of rats, and inhibited the growth of microscopic tumors in 42% of rats. OM-89 was effective when injected ip at the dose of 50 mg/kg, twice a week for 2 weeks. It was ineffective at the same dose when given orally every day for 14 or 21 days. The traces of endotoxins (0.0005%) were probably not involved in the antitumor effect of OM-89. No side-effects were observed.
Lagadec
P
P
INSERM, Unit 252, Faculty of Medicine, Dijon, France.
Onier
N
N
Bauer
J
J
Tourne
S
S
Jeannin
J F
JF
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D000942:Antigens, Bacterial; D001202:Ascitic Fluid / Q000628:therapy; D003110:Colonic Neoplasms / Q000556:secondary / Q000628:therapy*; D005260:Female; D007167:Immunotherapy; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy; D051381:Rats
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; C050501:OM 89