Renal and hemodynamic effects of atrial natriuretic peptide in patients with cirrhosis.
The effects of anaritide, a 25-amino-acid synthetic analogue of ANP, were evaluated in 28 patients with cirrhosis complicated by ascites and/or edema. Each patient received two doses of the agent, as well as an infusion of placebo. Six different doses were tested ranging from 0.015-0.300 microgram/kg/min. The infusions lasted for 2 hours and were flanked by both baseline and recovery periods. There was a significant effect of placebo on urinary sodium and chloride excretion rates but no effect on urine flow rate. In response to anaritide, the urine flow rate increased at 0.03, 0.06, 0.075, and 0.100 microgram/kg/min. The sodium and chloride excretion rates increased at all doses except the highest dose. There was no definite effect of anaritide on urinary potassium, calcium, and phosphate excretion rates. There was also no significant effect on creatinine clearance. The mean arterial pressure decreased in response to the 0.060, 0.075, and 0.100 microgram/kg/min doses. In addition, five of the patients receiving the highest dose (0.300 microgram/kg/min) had decreases in their systolic pressures to 90 mm Hg or less. In conclusion, anaritide is natriuretic and diuretic in patients with cirrhosis complicated by ascites and/or edema. Its effect, however, on arterial pressure may limit its therapeutic potential in this patient population.
Fried
T
T
Cleveland Metropolitan General Hospital, Case Western Reserve University, Ohio.
Aronoff
G R
GR
Benabe
J E
JE
Brunner
H R
HR
DiBona
G F
GF
Fleischhauer
T
T
Lam
M
M
Lawton
W J
WJ
Luft
F C
FC
Martinez-Maldonado
M
M
D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000652:urine; D002712:Chlorides / Q000652:urine; D004231:Diuresis; D004232:Diuretics; D004487:Edema; D005260:Female; D006400:Hematocrit; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000652:urine; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D010446:Peptide Fragments / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine
D002712:Chlorides; D004232:Diuretics; D010446:Peptide Fragments; D010710:Phosphates; C042703:anaritide; D009320:Atrial Natriuretic Factor; D008274:Magnesium; D011188:Potassium; D002118:Calcium