title: Improvement in the deformity of the face in Paget's disease treated with diphosphonates.
abstract: We studied nine patients with Paget's disease affecting the skull or facial bones, who were subsequently treated with either dichloromethylene diphosphonate (clodronate) or ethylene-1-hydroxy-1,1-diphosphonate (etidronate). Long-term treatment induced a clinical and biochemical improvement in eight, and this was associated with a reduction in maxillary or skull volume as assessed by quantitative stereophotogrammetry. The one patient whose disease was resistant to treatment with diphosphonate, showed no change in maxillary shape. These studies suggest that the long-term control of disease activity attained with diphosphonates, results in the improvement of skeletal deformity.
authors: University of Sheffield Medical School, England.
authors: D R
authors: DR
authors: Bickerstaff
authors: D L
authors: DL
authors: Douglas
authors: P H
authors: PH
authors: Burke
authors: D P
authors: DP
authors: O'Doherty
authors: J A
authors: JA
authors: Kanis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D002508:Cephalometry; D004002:Clodronic Acid / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000627:therapeutic use*; D005145:Face / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D010780:Photogrammetry; D012886:Skull / Q000473:pathology
chemical_list: D004164:Diphosphonates; D004002:Clodronic Acid; D000469:Alkaline Phosphatase; D012968:Etidronic Acid