title: Hepatic phase of malaria: a crucial role as "go-between" with other stages.
abstract: Besides potential interest in itself, the hepatic stage of malaria might play a crucial role as "go-between" with other stages. When present in the parasitophorous vacuole, antibodies induced by both sporozoite and erythrocytic stages efficiently disturb hepatic development of the parasite. Likewise previous and ensuing erythrocytic stages can modulate the "shielded" phase by cytokines, directly or as a result of a cascade of events, and by MHC-restricted or antibody-dependent cytotoxic mechanisms.
authors: INSERM U313, Groupe hospitalier Pitié-Salpêtrière, Paris, France.
authors: D
authors: D
authors: Mazier
authors: J
authors: J
authors: Goma
authors: S
authors: S
authors: Pied
authors: L
authors: L
authors: Renia
authors: A
authors: A
authors: Nussler
authors: F
authors: F
authors: Miltgen
authors: D
authors: D
authors: Mattei
authors: G
authors: G
authors: Grau
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D016207:Cytokines / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000469:parasitology*; D008954:Models, Biological; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D016207:Cytokines