A second consensus sequence of ATP-requiring proteins resides in the 21-kDa C-terminal segment of myosin subfragment 1.
Previous comparisons of sequence homologies of ATP-requiring enzymes have defined three consensus sequences which appear to be involved in the binding of the nucleotide. One of these was identified in the N-terminal 27-kDa segment of the myosin heavy chain but the other two sequences have not hitherto been located in myosin. The present paper proposes that one of these other two consensus sequences is in the 21-kDa C-terminal portion of S1 and that it may contribute to the ATP binding domain.
Burke
M
M
Department of Biology, Case Western Reserve University, Cleveland OH 44106.
Rajasekharan
K N
KN
Maruta
S
S
Ikebe
M
M
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001330:Electronic Data Processing; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D008969:Molecular Sequence Data; D008970:Molecular Weight; D015879:Myosin Subfragments / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D015003:Yeasts / Q000201:enzymology
D015879:Myosin Subfragments; D000251:Adenosine Triphosphatases