The production of a human monoclonal antibody defining a split of HLA-DRw13 (DRw13b).
By use of the heterohybridoma technique we have produced a human monoclonal antibody (NDS40) which detects a split of HLA-DRw13 (DRw13b) which is in linkage with HLA-DQw1. In addition, the antibody reacts with cells positive for HLA-DRw8 and DRw11, but does not react with the commonly found split of DRw13 (DRw13a) which is associated with DQw1. NDS40 is cytotoxic and is of the lambda IgM class.
Bunce
M
M
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, U.K.
Sutton
P M
PM
Ting
A
A
Morris
P J
PJ
D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006684:HLA-DR Antigens / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C080766:HLA-DR11 antigen; C097337:HLA-DR13 antigen; C041559:HLA-DR8 antigen; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains