title: The calcium-related basis of action of adenosine in rabbit aortic smooth muscle.
abstract: 1. In rabbit aortic smooth muscle, adenosine inhibited the increase induced by norepinephrine (NE) in 45Ca uptake in the presence of KCl (under low affinity Ca2+ uptake conditions) and the NE-induced decrease in 45Ca uptake (under high affinity Ca2+ uptake conditions). Basal 45Ca uptake and KCl-stimulated 45Ca uptake were not altered by adenosine. 2. Adenosine blocked the NE-induced contraction (in high K+) and inhibited both the tonic and phasic components of the NE-induced contraction. 3. Thus, adenosine selectively inhibits release of the intracellular Ca2+ store important for the phasic response to NE and that Ca2+ uptake component important for the NE-induced tonic response.
authors: Research Department, CIBA-GEIGY Corporation, Summit, NJ 07901.
authors: J V
authors: JV
authors: Zawadzki
authors: G B
authors: GB
authors: Weiss
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002118:Calcium / Q000502:physiology*; D002132:Calcium Radioisotopes; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits
chemical_list: D002132:Calcium Radioisotopes; D004533:Egtazic Acid; D011189:Potassium Chloride; D007811:Lanthanum; D000241:Adenosine; D002118:Calcium; D009638:Norepinephrine