Different glycosylation of human prolactin in cystic fibrosis patients.
1. The elevated (Cl) of sweat from cystic fibrosis (CF) skin reverted to normal after the skin had been grafted onto immunoincompetent, congenitally athymic mice [N'NIH(S)-NU]. 2. The sweat (Cl) of CF skin grafts unlike that from normal skin did not increase when the host mice were injected with antibodies to human prolactin (hPRL). 3. One explanation for the above observations postulated a structurally modified PRL in CF patients. Circulating PRL in CF appears to contain a larger amount of glycosylated variants than that of healthy individuals.
Robertson
M T
MT
Department of Pediatrics, Georgetown University, Washington, D.C.
Boyajian
M J
MJ
Kulczycki
L L
LL
Martin
A L
AL
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D006031:Glycosylation; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011388:Prolactin / Q000378:metabolism*; D016038:Skin Transplantation; D013545:Sweat Glands / Q000378:metabolism
D002712:Chlorides; D011388:Prolactin