Immunohistochemical localization of a plasma protein (glycoprotein 60) which inhibits complement-mediated prevention of immune precipitation.
Using various immunocytochemical techniques it has been shown that glycoprotein 60 (gp60), an IgG Fc-binding protein recently isolated from normal human plasma, is found localized in human hepatocytes, platelets and a subpopulation of normal peripheral blood lymphocytes (PBL). This protein, which appears to be identical to a 60,000 MW IgG-binding protein (60-IBF) previously isolated from normal human PBL culture supernatants, also appears to be distinct from the three well-defined leucocyte Fc gamma-receptors: Fc gamma RI, Fc gamma RII and Fc gamma RIII.
Sandilands
G P
GP
University Department of Pathology, Western Infirmary, Glasgow.
Ahmed
A E
AE
Griffiths
M R
MR
Whaley
K
K
D015703:Antigens, CD / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis*; D001773:Blood Cells / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D008099:Liver / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D011233:Precipitin Tests; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG; D012397:Rosette Formation
D015703:Antigens, CD; D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG; D003165:Complement System Proteins