[Diagnosis of cerebral toxoplasmosis in AIDS patients. Value of antibodies evaluation in cerebrospinal fluid].
The purpose of this study was to evaluate the diagnostic value of search for intrathecally synthesized specific antibodies in cerebral toxoplasmosis. Intrathecal synthesis of antibodies was measured by calculating the immunity load coefficient (ILC) in both serum and cerebrospinal fluid. In this retrospective study the records of 42 AIDS patients with clinically on the basis of computerized tomography and therapeutic results, and was excluded in 31 patients (control group). Specific immunoglobulins G were found in the cerebrospinal fluid of 9 out of the 11 patients with toxoplasmosis, but also in 14 of the 31 controls. Since ILC measurements in serum and cerebrospinal fluid identified 7/11 cases other hand, since the ILC value was higher than the positivity threshold in controls, the specificity of the test was assessed at 68 percent.
Bougnoux
M E
ME
Laboratoire de Parasitologie-Mycologie, Hôpital Cochin, Paris.
Nicaise
P
P
Heyer
F
F
Ancelle
T
T
Pinquier
J L
JL
Dupouy-Camet
J
J
Tourte-Schaeffer
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D012016:Reference Values; D012189:Retrospective Studies; D014123:Toxoplasmosis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology
D007075:Immunoglobulin M
Diagnostic de la toxoplasmose cérébrale chez les sidéens. Valeur de la recherche d'anticorps dans le liquide céphalo-rachidien.