[Preliminary observations on the effect of sjamp on the fibrinolytic system].
The effects of Sjamp, an acidic mucopolysaccharide extracted from Stichopus japonicus Selenka, on fibrinolytic activities were studied. The results showed that Sjamp could induce fibrinolysis in vitro, and the effects were stronger than those of heparin. The fibrinolytic activity of Sjamp disappeared when plasminogen was removed from the fibrin clot. This suggested that the fibrinolytic activity of Sjamp might depend upon plasminogen activation. The fibrinolytic activity and FDP concentration of rabbit plasma increased after intravenous injection of Sjamp. Fibrin monomer polymerization (FMP) was also inhibited by Sjamp, so the structure of fibrin clots might be altered, facilitating lysis. The mechanism of fibrinolytic effect of Sjamp and the significance of this effect in biomedicine are discussed.
Yang
X G
XG
Institute of Hematology, Tianjin.
D000818:Animals; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D011817:Rabbits; D012616:Sea Cucumbers; D013916:Thrombelastography
D005338:Fibrin Fibrinogen Degradation Products; D006025:Glycosaminoglycans