The Iowa multiplex family study of schizophrenia: linkage analyses on chromosome 5.
We analysed six multiplex pedigrees of schizophrenia for linkage to two DNA probes mapping to the chromosome 5q11-q13 region where linkage to a gene for schizophrenia was recently reported. Analyses were conducted using three penetrance models and considering the affected state to be schizophrenia, the schizophrenia spectrum, and all psychiatric diagnoses. All analyses gave consistently negative lod scores. Although the region was not formally excluded, no evidence for linkage was found.
Crowe
R R
RR
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Black
D W
DW
Andreasen
N C
NC
Huether
M
M
D002895:Chromosomes, Human, Pair 5; D015342:DNA Probes; D003866:Depressive Disorder / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007484:Iowa; D008957:Models, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000235:genetics
D015342:DNA Probes; D005819:Genetic Markers