Circulating immunoreactive endothelin in ischemic heart disease.
Circulating immunoreactive endothelin (ir-ET) was measured in nine patients with acute myocardial infarction (AMI), 10 patients with stable angina pectoris (SAP), and 25 normal control subjects. In patients with AMI, the plasma ir-ET level was elevated in the acute phase and was highest on the day of onset (AMI: 3.8 +/- 1.7 pg/ml, normal control value: 0.5 +/- 0.2 pg/ml). The plasma ir-ET level showed a positive correlation with the wall motion abnormality index (rs = 0.56, p less than 0.01), thrombin-antithrombin III complex (rs = 0.55, p less than 0.01), and beta thromboglobulin (rs = 0.39, p less than 0.05). An especially high plasma ir-ET level was detected in patients in whom the Killip subset was IV. The plasma ir-ET level was not increased in patients with SAP (0.8 +/- 0.3 pg/ml). The plasma ir-ET level is increased in the acute phase of AMI. A pathophysiologic state characterized by cardiac dysfunction, an activated coagulation system, and platelet hyperactivity may be associated with this increase in plasma ir-ET.
Yasuda
M
M
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kohno
M
M
Tahara
A
A
Itagane
H
H
Toda
I
I
Akioka
K
K
Teragaki
M
M
Oku
H
H
Takeuchi
K
K
Takeda
T
T
D000787:Angina Pectoris / Q000097:blood* / Q000175:diagnosis; D000990:Antithrombin III / Q000032:analysis; D004452:Echocardiography; D016232:Endothelins; D004730:Endothelium, Vascular / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis; D010447:Peptide Hydrolases / Q000032:analysis; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay; D001620:beta-Thromboglobulin / Q000032:analysis
D016232:Endothelins; D010455:Peptides; C046193:antithrombin III-protease complex; D001620:beta-Thromboglobulin; D000990:Antithrombin III; D010447:Peptide Hydrolases