title: NMDA lesions of rat lateral hypothalamus: effects of dietary and physiological challenges.
abstract: Rats bearing NMDA lesions of the lateral hypothalamus (LH) were tested for their reactions to alterations in the sensory (but not calorific) content of the diet (finickiness), to 24 h food or water deprivation, and to dehydrating injections of hypertonic saline and glucoprivic injections of 2-deoxy-D-glucose (2-DG). Lesioned rats lost weight following surgery but had no significant eating or drinking difficulties in the home cage. They were not finicky and responded normally to 24 h food or water deprivation. Responses to hypertonic saline and 2-DG challenges were significantly impaired. These data suggest a subtle motivational disorder following LH lesion, rather than motor or sensory impairment.
authors: Department of Psychology, University of St Andrews, Fife, UK.
authors: A J
authors: AJ
authors: Clark
authors: J M
authors: JM
authors: Clark
authors: P
authors: P
authors: Winn
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism; D005508:Food Deprivation; D005518:Food Preferences; D006982:Hypertonic Solutions / Q000494:pharmacology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009042:Motivation; D016202:N-Methylaspartate / Q000633:toxicity*; D051381:Rats; D014868:Water Deprivation; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D006982:Hypertonic Solutions; D016202:N-Methylaspartate; D003847:Deoxyglucose