In-vitro comparison of the post-antibiotic effect of vancomycin and teicoplanin.
The post-antibiotic effect (PAE) of teicoplanin was compared with that of vancomycin for five selected Gram-positive cocci. Two concentrations of each antibiotic were investigated, with the test organisms being exposed to each for both 1 and 2 h. At a concentration of 25 mg/l, teicoplanin had a greater PAE than vancomycin for the methicillin resistant staphylococci and Enterococcus faecalis strains tested. At a concentration of 5 mg/l, teicoplanin gave equal effects to those of vancomycin except for the strain of methicillin-resistant Staphylococcus aureus (MRSA) tested. The variation in the antibiotic exposure time gave only small changes in the PAE, except for the MRSA tested.
Cooper
M A
MA
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
Jin
Y F
YF
Ashby
J P
JP
Andrews
J M
JM
Wise
R
R
D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D006020:Glycopeptides / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects* / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D017334:Teicoplanin; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin; D008712:Methicillin