title: A comparative study of the effects of verapamil and cimetidine on isolated rat stomach strip.
abstract: Effects of verapamil and cimetidine were studied on smooth muscle of rat stomach by using an isolated fundus strip preparation. Verapamil 0.5 microgram/ml significantly (P less than 0.001) reduced acetylcholine (Ach) induced contractions of rat stomach fundus strip. The inhibition was very prolong and dose dependent. On the other hand cimetidine 60 micrograms/ml significantly (P less than 0.001) potentiated the Ach-induced contractions, potentiation was dose related. The spontaneous contractions of stomach strip were completely abolished by 8 micrograms/ml verapamil, whereas 1000 micrograms/ml cimetidine had no effect. It was concluded that verapamil given for cardiovascular disorders would also supplement relief of pain from peptic ulcer and might prevent stress ulcer formation.
authors: Department of Pharmacology, Rawalpindi Medical College.
authors: T A
authors: TA
authors: Nishat
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010437:Peptic Ulcer / Q000517:prevention & control; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D002927:Cimetidine; D014700:Verapamil; D000109:Acetylcholine