Effect of medium-chain triglycerides (MCT) as an energy substrate after hepatectomy in rats with streptozotocin-induced diabetes.
The suitability of energy substrates used by the remnant liver after a 70% partial hepatectomy was studied in relation to the hepatic energy status in diabetic rats. Rats with streptozotocin-induced diabetes mellitus underwent 70% hepatectomy, and were divided into three groups receiving total parenteral nutrition (TPN) for 24h. One group received standard TPN without fat, while two other groups received standard TPN with medium-chain triglycerides (MCTs) or long-chain triglycerides (LCTs) as a 10% lipid emulsion. All rats of the TPN group without fat died within 24h. Blood ketone body ratios (aceto-acetate/beta-hydroxybutyrate), energy charge levels of the remnant liver, and cumulative amounts of 14CO2 in the expired breath during the 6h following 14C-labeled fat emulsion administration (MCT or LCT) were all significantly higher in the MCT group than in the LCT group 24h after hepatectomy. These findings suggest that medium-chain fatty acids (MCFAs) as an energy substrate are superior to long-chain fatty acids (LCFAs) during the immediate posthepatectomy phase in diabetics.
Mitsuyoshi
K
K
Department of Surgery, Kansai Medical University, Osaka, Japan.
Hiramatsu
Y
Y
Nakagawa
M
M
Yamamura
M
M
Hioki
K
K
Yamamoto
M
M
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000601:surgery; D004734:Energy Metabolism; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000378:metabolism; D006498:Hepatectomy; D007657:Ketone Bodies / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D014280:Triglycerides / Q000008:administration & dosage* / Q000378:metabolism
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D007657:Ketone Bodies; D008112:Liver Glycogen; D014280:Triglycerides; D013311:Streptozocin; D009584:Nitrogen