Evidence that atriopeptin is not a physiological regulator of sodium excretion.
Although much experimental evidence is consistent with the concept that atrial natriuretic factor (atriopeptin) is an important physiological regulator of renal sodium excretion, this hypothesis remains unproven. Indeed, a rapidly expanding collection of experimental data appears to be more compatible with the opposite conclusion, namely that circulating atriopeptin exerts only a trivial effect on renal sodium excretion during normal day-to-day living conditions. In this review, the substantial evidence demonstrating that elevations of plasma atriopeptin from threefold to 13-fold produce only a slowly developing and relatively modest natriuresis is reassessed in light of recently published data indicating that the acute intake of food (the pathway by which essentially all sodium enters the body under normal living conditions) does not increase circulating atriopeptin. These considerations imply that atriopeptin does not contribute to the process that elicits a postprandial natriuresis, a process that presumably is of primary importance in the physiological regulation of sodium balance. In addition, consideration is given to a number of common physiological, experimental, and pathophysiological conditions in which circulating atriopeptin does not correlate with renal sodium excretion. This lack of correlation implies that atriopeptin is not an important regulator of sodium excretion in these situations.
Goetz
K L
KL
Division of Experimental Medicine, St. Luke's Hospital and Foundation, Kansas City, Missouri 64111-9000.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D004039:Diet, Sodium-Restricted; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006325:Heart Atria; D006439:Hemodynamics; D006801:Humans; D009318:Natriuresis / Q000502:physiology; D012964:Sodium / Q000652:urine*
D009320:Atrial Natriuretic Factor; D012964:Sodium