[Morphohistochemical study of skeletal muscles in rats after experimental flight on "Kosmos-1887"].
Morphometric and histochemical methods were used to examine the soleus, gastrocnemius (medial portion), quadriceps femoris (central portion) and biceps brachii muscles of Wistar SPF rats two days after the 13-day flight on Cosmos-1887. It was found that significant atrophy developed only in the soleus muscle. The space flight did not change the percentage content of slow (type I) and fast (type II) fibers in fast twitch muscles. During two days at 1 g the slow soleus muscle developed substantial circulation disorders, which led to interstitial edema and necrotic changes. The gastrocnemius muscle showed small foci containing necrotic myofibers. Two days after recovery no glycogen aggregates were seen in myofibers, which were previously observed in other rats examined 4--8 hours after flight. An initial stage of muscle readaptation to 1 g occurred, when NAD.H2-dehydrogenase activity was decreased.
Il'ina-Kakueva
E I
EI
D000337:Aerospace Medicine; D000818:Animals; D004195:Disease Models, Animal; D006651:Histocytochemistry; D008297:Male; D009132:Muscles / Q000737:chemistry / Q000201:enzymology / Q000473:pathology*; D009133:Muscular Atrophy / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D009218:Myosins / Q000737:chemistry / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014586:USSR
D009245:NADH Dehydrogenase; D009218:Myosins
Morfogistokhimicheskoe issledovanie skeletnykh myshts krys v éksperimente na biosputnike "Kosmos-1887".