title: [Methodology of hygienic standardization of allergenic mixtures of stable composition (a model of combined veterinary preparations)].
abstract: The article presents the experimental study results of a comparative assessment of the allergenic activity of three newly developed veterinary preparations (both their major components and complete combined forms)--rivicycline, sulphapen and geovet . No increase in sensibilization was traced, and some indicators showed a weakened sensitizing ++ action of the combined preparations in comparison with the respective doses of the constituent allergic components. The allergy inducing components were determined. The authors recommended hygienic norm of the combined veterinary preparations, as mixtures with permanent composition, by their major allergic components. The proposed technique of a comparative express-test of allergic mixtures and their components may be recommended as another approach to express hygienic norming of the allergens.
authors: L A
authors: LA
authors: Dueva
authors: T F
authors: TF
authors: Khil'ko
authors: L I
authors: LI
authors: Kalinina
mesh_terms: D000818:Animals; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects; D006168:Guinea Pigs; D008709:Methenamine / Q000008:administration & dosage / Q000009:adverse effects*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000009:adverse effects*; D010404:Penicillin V / Q000008:administration & dosage / Q000009:adverse effects*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D013421:Sulfamethoxypyridazine / Q000008:administration & dosage / Q000009:adverse effects*; D013752:Tetracycline / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: C067726:rivicycline; C067727:sulfapen; C067728:geovet; D013752:Tetracycline; D008709:Methenamine; D013421:Sulfamethoxypyridazine; D012293:Rifampin; D010118:Oxytetracycline; D010404:Penicillin V
vernacular_title: K metodologii gigienicheskogo normirovaniia allergennykh smeseĭ postoiannogo sostava (na modeli kombinirovannykh veterinarnykh preparatov).