Sr and Ba transients in isolated snail neurones studied with fura-2. The recovery from depolarization induced load and modulation of Ca release from intracellular stores.
The fluorescent Ca-sensitive probe fura-2 was used in isolated non-identified neurons of the snail, Helix pomatia, to study the recovery from Sr and Ba loading and the effect of these cations on Ca-induced Ca release. Sr was shown to behave similarly to Ca, whereas Ba ions were not sequestered within the cell. Intracellular Ba blocked both the voltage-gated channels in the plasma membrane and the Ca release channels in the membrane of intracellular stores.
Mironov
S L
SL
A.A. Bogomoletz Institute of Physiology, Kiev, U.S.S.R.
Juri
M U
MU
D000818:Animals; D001464:Barium / Q000502:physiology*; D001572:Benzofurans; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D005456:Fluorescent Dyes; D016257:Fura-2; D006372:Helix, Snails / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013324:Strontium / Q000502:physiology*
D001572:Benzofurans; D005456:Fluorescent Dyes; D001464:Barium; D002118:Calcium; D016257:Fura-2; D013324:Strontium