title: In vitro aldose reductase inhibitory activity of N-aryl-glycine derivatives and their thioisosters.
abstract: A series of N-arylglycine derivatives and their thioisosters (1-10) was synthesized and evaluated as in vitro aldose reductase inhibitors. Among these, (6-chloro-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)-2-propanoic acid (5) shows an inhibitory activity (IC50:5.1 microM) comparable to Alrestatin.
authors: Cattedra di Chimica Farmaceutica e Tossicologica della Facoltà di Farmacia, Università di Modena.
authors: L
authors: L
authors: Costantino
authors: C
authors: C
authors: Parenti
authors: M
authors: M
authors: Di Bella
authors: M
authors: M
authors: Baraldi
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005123:Eye / Q000201:enzymology; D006852:Hydrochlorothiazide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006852:Hydrochlorothiazide; D000449:Aldehyde Reductase