title: Afferent lymph dendritic cells: a model for antigen capture and presentation in vivo.
abstract: We review the phenotypic and functional properties of sheep afferent lymph dendritic cells. These dendritic cells bear surface immunoglobulin and can acquire antigen/antibody complexes, both in vitro and in vivo. Our data suggest a role for Fc receptors in the capture of antigen by these cells. Dendritic cells collected after in vivo antigen pulsing are capable of stimulating T cell proliferation in an antigen-specific manner. Afferent dendritic cells express all the known groups of presentational molecules involved in activation of T cells, namely MHC class I and class II, and CD1. These results suggest a role for afferent dendritic cells in the activation of alpha beta and gamma delta T cells.
authors: Department of Veterinary Pathology, University of Edinburgh, Scotland, UK.
authors: R
authors: R
authors: Bujdoso
authors: G
authors: G
authors: Harkiss
authors: J
authors: J
authors: Hopkins
authors: I
authors: I
authors: McConnell
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008196:Lymph / Q000166:cytology*; D008213:Lymphocyte Activation; D008954:Models, Biological; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D011961:Receptors, Fc / Q000378:metabolism; D012756:Sheep / Q000033:anatomy & histology / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D015815:Cell Adhesion Molecules; D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc