Recognition of self class II major histocompatibility complex antigens by CD8+ T cell clones derived from rheumatoid arthritis synovial membrane.
T cells from rheumatoid synovium have been expanded in vitro as lines and clones using autologous Epstein-Barr virus-transformed stimulator cells. Both lines and clones recognized autologous class II MHC antigens in the absence of defined exogenous antigens i.e. the equivalent of the autologous mixed lymphocyte response. Surprisingly, despite their MHC specificity, several clones expressed CD8 rather than CD4, but were not cytotoxic. The function of CD8+ T cells within synovium has not previously been defined; in view of their unusual phenotype, they may exert an immuno-modulating role upon the inflammatory response within the joint, by responding to the high density of class II MHC antigens expressed in the rheumatoid synovium.
Gaston
J S
JS
Division of Immunology, Stanford University Medical Center, California.
Solovera
J
J
Strober
S
S
D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens; D002455:Cell Division; D002470:Cell Survival; D002999:Clone Cells / Q000276:immunology; D015802:HLA-DR2 Antigen / Q000276:immunology; D015805:HLA-DR5 Antigen / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D013583:Synovial Membrane / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D015802:HLA-DR2 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II