title: Effect of carminomycin on the viability of fibroblasts from patients with regular trisomy 21.
abstract: The sensitivity of three human fibroblast lines, trisomic with respect to chromosome 21, to an anthracycline antibiotic carminomycin was compared with that of a normal fibroblast line using a 51Cr release assay. It was found that for an intermediate antibiotic concentration (10 microM) the sensitivity of trisomic fibroblasts, of increased content of Cu,Zn-superoxide dismutase was lower. These results suggest a role for superoxide-mediated membrane damage in the cytotoxic action of anthracycline antibiotics.
authors: Department of Biophysics, University of Lodz, Poland.
authors: B
authors: B
authors: Rózga
authors: A V
authors: AV
authors: Peskin
authors: G
authors: G
authors: Bartosz
mesh_terms: D002360:Carubicin / Q000494:pharmacology*; D002478:Cells, Cultured; D002857:Chromium / Q000378:metabolism*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004314:Down Syndrome / Q000201:enzymology / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D002857:Chromium; D002360:Carubicin; D013482:Superoxide Dismutase; D003630:Daunorubicin