MRI contrast media for the liver. Efficacy in conditions of acute biliary obstruction.
The authors investigated in a rat model the efficacy of magnetic resonance imaging (MRI) contrast media for evaluating the liver in conditions of acute biliary obstruction. Two liver-specific MRI contrast media, Cr-DEHIDA and Mn-DPDP, and the nonspecific agent Gd-DTPA were studied in normal rats and in rats whose bile ducts had been ligated before administration of the contrast medium. Images were made using a 2.4 T animal MRI system, and intensity enhancement of liver after contrast medium injection was calculated. Metal analyses of serum and liver tissue and T1 and T2 measurements on liver samples in vitro were performed. The differences in image intensity enhancement of liver between normal rats and rats with ligated bile ducts were not significant for any of the three contrast media. Imaging with Mn-DPDP resulted in the highest intensity enhancement of the liver compared with Cr-DEHIDA and Gd-DTPA. Contrast media concentrations in liver tissue were not significantly different between normal rats and rats with ligated bile ducts; however, Cr-DEHIDA concentrations in serum were higher after bile duct ligation. In vitro measurements of liver tissue indicated unique relaxation properties for Mn-DPDP. This investigation indicates that the contrast media studied may be useful in situations where suspected liver pathology is complicated by acute biliary obstruction.
Leander
P
P
Department of Experimental Research, University of Lund, Malmö, Sweden.
Golman
K
K
Klaveness
J
J
Holtz
E
E
Olsson
M
M
Leunbach
I
I
D000818:Animals; D002779:Cholestasis / Q000175:diagnosis*; D002857:Chromium; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives; D005069:Evaluation Studies as Topic; D005682:Gadolinium; D019786:Gadolinium DTPA; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D009942:Organometallic Compounds; C067720:chromium(III)bis(N-(2,6-diethylphenylcarbamoylmethyl)iminodiacetic acid)meglumine; D002857:Chromium; D008345:Manganese; D011732:Pyridoxal Phosphate; D008536:Meglumine; D004369:Pentetic Acid; D004492:Edetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid