[In vitro evaluation of antimicrobial activity of fusafungine].
Fusafungine is an antibiotic extracted from the fungus Fusarium laterium WR strain 437. The antimicrobial activity of fusafungine was determined on strains from laboratory collections and clinical isolates; since fusafungine is not soluble in the classical media, the usual techniques had to be modified. MICs for all the Gram-positive cocci and bacteria tested, aerobic, or anaerobic, were below 30 mcg/ml. The antimicrobial activity included Mycoplasma pneumoniae (MIC less than 18 mcg/ml) and Streptococcus mutans (MIC less than 30 mcg/ml). An antifungal activity was shown for most of the Candida albicans tested (MIC less than 32 mcg/ml) and for different Nocardia sp. (MIC less than 13 mcg/ml). Moreover, fusafungine induced neither acquired resistance nor cross-resistance towards the antibiotics classically used in therapy.
German-Fattal
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M
Centre d'Etudes Pharmaceutiques, Université de Paris XI, Châtenay-Malabry.
German
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A
D000336:Aerosols / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D047630:Depsipeptides; D005670:Fusarium; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D009615:Nocardia / Q000187:drug effects; D015610:Serum Bactericidal Test; D013295:Streptococcus mutans / Q000187:drug effects
D000336:Aerosols; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C014001:fusafungin
Evaluation in vitro de l'activité antimicrobienne de la fusafungine.