Medical treatment of mild endometriosis in infertile women: analysis of a failure.
The easy access to the pelvis of infertile women by laparoscopy favours early diagnosis of endometriosis in an increasing number of subjects with minimal and mild disease. These initial forms have been associated with and considered as the cause of infertility despite the absence of relevant scientific evidence. Various hormone therapies, some with severe side-effects and high costs, have been used by numerous authors. However, no study comparing medically treated with untreated women has ever shown any drug to be more effective than expectant management. The possible explanations of treatment failures are reviewed.
Candiani
G B
GB
First Department of Obstetrics and Gynaecology, University of Milan School of Medicine, Italy.
Vercellini
P
P
Fedele
L
L
Bocciolone
L
L
Bianchi
C
C
D002064:Buserelin / Q000627:therapeutic use; D003613:Danazol / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D005867:Gestrinone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D017274:Nafarelin
D005867:Gestrinone; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D003613:Danazol; D002064:Buserelin