Lymphocytic mechanisms of myelopoiesis regulation under stress.
The role of T-lymphocytes in the regulation of bone marrow haemopoiesis was investigated under conditions of immobilization stress in mice. Development of the general adaptation reaction was accompanied by hyperplasia of the bone tissue at the level both of the committed precursor cells and of the morphologically differentiated haemopoietic cells. The existence of a subpopulation of T-cells expressing the Lyt-1+,Lyt-2+,L3T4-antigens on their surface is demonstrated. T-lymphocytes with this phenotype migrated into the bone marrow of stressed mice and stimulated the proliferation and differentiation of erythroid and granulocyto-macrophagal precursors.
Gol'dberg
E D
ED
Laboratory of Pathological Physiology and Experimental Therapy, Academy of Medical Sciences of the USSR, Tomsk.
Dygai
A M
AM
Shakhov
V P
VP
Bogdashin
I V
IV
Mikhlenko
A V
AV
D000818:Animals; D000961:Antilymphocyte Serum; D001853:Bone Marrow / Q000473:pathology; D006410:Hematopoiesis; D006965:Hyperplasia; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011817:Rabbits; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000276:immunology / Q000503:physiopathology*; D016176:T-Lymphocyte Subsets / Q000502:physiology* / Q000637:transplantation; D013950:Thymus Gland / Q000502:physiology / Q000637:transplantation
D000961:Antilymphocyte Serum