Uptake and release of calcium ions by heavy sarcoplasmic reticulum fraction of normal and malignant hyperthermia-susceptible human skeletal muscle.
1. Ca2+ uptake, Ca2(+)-dependent ATPase activity and halothane-induced Ca2+ release from the heavy sarcoplasmic reticulum fraction of muscle from malignant hyperthermia susceptible individuals are similar to those of normal human muscle. 2. Ca2(+)-induced Ca2+ release from the diseased muscle was increased by 13%.
McSweeney
D M
DM
Department of Biochemistry, University College, National University of Ireland, Cork.
Heffron
J J
JJ
D001386:Azides / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003620:Dantrolene / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia / Q000378:metabolism*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D019810:Sodium Azide
D001386:Azides; D010664:Phenylmethylsulfonyl Fluoride; D019810:Sodium Azide; D000252:Calcium-Transporting ATPases; D003620:Dantrolene; D002118:Calcium; D006221:Halothane