[Effect of celiprolol on isoprenaline-induced myocardial necrosis].
The assessed elevated catecholamine levels in the organism during substantial physical or mental stress lead to changes in the heart rate and to intensification of contractions. The demands of the heart muscle as regards increased oxygen supplies and are not met. This may have serious consequences for the patient. The authors wanted to find out therefore whether the beta-blocker celiprolol will be able to reduce the negative effect of large amounts of catecholamine in the organism and thus play a part in the prevention of myocardial damage. When celiprolol was administered half an hour before isoprenaline, the extent of necrosis caused by catecholamine was reduced. When administered half an hour after isoprenaline administration, the marked protective effect was no longer observed. The necroses in the heart muscle were similar as in animals given catecholamine only.
Mitova
M
M
Ustav patologické anatomie lékarské fakulty Univerzity Masarykovy, Brno.
Lupínek
Z
Z
Bednarík
B
B
Cerný
E
E
Foukal
T
T
D000818:Animals; D017272:Celiprolol; D006321:Heart / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011412:Propanolamines; D017272:Celiprolol; D007545:Isoproterenol
Ovlivnĕní izoprenalinových nekróz myokardu celiprololem.