title: Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in north west Europe and Siberia.
abstract: Recently morbilliviruses were isolated from harbour seals (Phoca vitulina) in North West Europe (phocid distemper virus-1: PDV-1) and from Baikal seals (Phoca sibirica) in Siberia (phocid distemper virus-2: PDV-2) during outbreaks of severe disease which resembled distemper in dogs. PDV-1 and PDV-2 were passaged in SPF dogs, in which they caused distemper-like disease symptoms, and were subsequently passaged in Vero cells in which they caused cytopathic changes. PDV-1, PDV-2, and canine distemper virus (CDV) were compared with respect to their biological, morphological, physical, protein chemical, and antigenic properties. It was concluded that PDV-1 should be considered a newly recognized member of the genus Morbillivirus, whereas PDV-2 proved to be quite similar if not identical to CDV.
authors: Laboratory of Immunobiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
authors: I K
authors: IK
authors: Visser
authors: V P
authors: VP
authors: Kumarev
authors: C
authors: C
authors: Orvell
authors: P
authors: P
authors: de Vries
authors: H W
authors: HW
authors: Broeders
authors: M W
authors: MW
authors: van de Bildt
authors: J
authors: J
authors: Groen
authors: J S
authors: JS
authors: Teppema
authors: M C
authors: MC
authors: Burger
authors: F G
authors: FG
authors: UytdeHaag
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D010872:Caniformia / Q000382:microbiology*; D004196:Disease Outbreaks / Q000662:veterinary; D004285:Dogs; D007158:Immunologic Techniques; D010252:Paramyxoviridae / Q000145:classification / Q000302:isolation & purification*; D010253:Respirovirus Infections / Q000382:microbiology / Q000662:veterinary*; D046048:Seals, Earless / Q000382:microbiology*; D012692:Serial Passage; D013047:Specific Pathogen-Free Organisms; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D014764:Viral Proteins