Current concepts in autoimmunity.
Autoimmune diseases are subsequent to tissue damage mediated by an immune reaction directed toward autoantigens. Activation of CD4+ T cells reactive to carrier determinants on foreign antigenic complexes or autoreactive CD4+ T cells are central to the triggering of immune effector mechanisms. Transfer experiments in animals, demonstration of suppressor T cells, study of antigen-presenting cells--CD4+ T cells interaction, isolation of T cell clones and study of transgenic mice have recently brought new insight into the understanding of autoimmunity.
Boitard
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INSERM U25, Hôpital Necker, Paris, France.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015551:Autoimmunity; D015704:CD4 Antigens; D002999:Clone Cells; D006801:Humans; D007116:Immunization, Passive; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015704:CD4 Antigens