Immunology of Pseudomonas aeruginosa infection in cystic fibrosis.
Adherence of P. aeruginosa to the lining of the respiratory tract is probably mediated by interaction of pili or alginate with lactosyl and sialosyl residues on the respiratory cells. The toxins produced by P. aeruginosa (for example, elastase and alkaline protease) may play a key role during the initial persistent colonization as they interfere with important defense mechanisms. Neutralizing antibodies are eventually produced, and a poor prognosis is correlated to a pronounced antibody response. The bacteria are protected against the host's defense mechanisms by production of alginate which encapsulates microcolonies of P. aeruginosa in the lungs. During the chronic infection, toxins of P. aeruginosa probably play little if any direct pathogenic role, however, immune complexes seem to be a major trigger of chronic inflammation in the lungs. Proteolytic enzymes and oxygen radicals released from the abundance of neutrophils in the lungs are probably responsible for most of the tissue damage. The individual course of the chronic infection may be explained by regulatory mechanisms, such as cleavage of immune complexes by neutrophil elastase, and by the balance between the different IgG subclass-specific antibody responses.
Høiby
N
N
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Pedersen
S S
SS
Jensen
E T
ET
Pressler
T
T
Shand
G H
GH
Kharazmi
A
A
Döring
G
G
D001422:Bacterial Adhesion; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D011552:Pseudomonas Infections / Q000209:etiology* / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity