Study of quantitative modifications of the plasma protein S system components in non-acute inflammatory syndromes.
Thrombosis frequently accompanies inflammatory disease. There are numerous and frequent modifications of haemostasis parameters during inflammatory disease. Deficiencies in protein S, a protein C cofactor, are predisposing factors for thromboses. In 43 patients with biological inflammatory syndromes (ESR above 80 mm in the first hour found twice in a three-day period and disturbances of other biological inflammatory markers) we studied the variations of the protein S system: total antigenic protein S, free antigenic protein S, C4b BP, all antigenic fractions being assayed by electro-immuno diffusion. The results show an increase in free protein S (mean 114.3%, range 25%-180%, P less than 0.005), the biologically active fraction of protein S. They also evidence the expected increase in C4b BP (mean 188.3%, range 41%-335%, P less than 10(-5]. There is an increase in total protein S Ag (mean 145.3%, range 56%-220%, P less than 10(-5]. The results show a high positive correlation between the increased free protein S Ag and total protein S Ag (r' = 0.78, P less than 0.01), between total protein S and C4b BP (r' = 0.8, P less than 0.01) and between free protein S and C4b BP (r' = 0.73, P less than 0.01). C4b BP concentrations are correlated with haptoglobin (r' = 0.59, P less than 0.01), orosomucoid (r' = 0.53, P less than 0.01), C3 complement component (r' = 0.80, P less than 0.01), C4 (r' = 0.39, P less than 0.02) and platelet count (r' = 0.51, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Schved
J F
JF
Laboratoire d'Hématologie et Immunologie, Centre Hospitalier Régional et Universitaire de Nîmes, France.
Gris
J C
JC
Sarlat
C
C
Amiral
J
J
Brun
S
S
Brunschwig
C
C
Petris
I
I
Lassonery
M
M
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002908:Chronic Disease; D015935:Complement C4b / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007158:Immunologic Techniques; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017293:Protein S; D013577:Syndrome
D001798:Blood Proteins; D006023:Glycoproteins; D017293:Protein S; D015935:Complement C4b