title: Plasma aldosterone concentration during hypoxia, stimulated hyperglycaemia and when protein synthesis is blocked with actinomycin D.
abstract: In order to study the effect of various agents on aldosterone secretion, the aldosterone concentration was determined radioimmunologically in 41 rats divided in groups: group I--7 rats--controls; group II--11 rats loaded p.o. with 5.5% glucose solution in doses of 2.4 ml/100 g body weight, taking the blood sample 2 hours after the loading; group III--7 rats subjected to the same treatment, but the blood was taken 6 hours later; group IV--7 rats subjected to hypobaric hypoxy for 2 hours; group V--9 rats treated with 40 ug/100 g b. w. actinomycin D and then subjected to hypoxy for 2 hours. The blood sample from the last two groups was taken 3 hours after the end of the hypoxy. The radioimmunological determination was made using a kit of the firm Sorin--Biomedica. The results show that glucose and hypoxy act as stimulators of aldosterone secretion.
authors: Department ol Physiology, Higher Medical Institute, Stara Zagora.
authors: G
authors: G
authors: Ilieva
authors: A
authors: A
authors: Tolekova
authors: A
authors: A
authors: Logofetov
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D006943:Hyperglycemia / Q000097:blood*; D000860:Hypoxia / Q000097:blood*; D007202:Indicators and Reagents; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D007202:Indicators and Reagents; D003609:Dactinomycin; D000450:Aldosterone