Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats.
Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.
Yamada
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Fuji
K
K
Nabeshima
T
T
Kameyama
T
T
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006426:Hemicholinium 3 / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011805:Quinolinic Acids; D006426:Hemicholinium 3; D016291:Dizocilpine Maleate; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D017378:Quinolinic Acid