title: [Effect of injection of thyrotropin-releasing hormone into nucleus accumbens on the pain discharges in nucleus parafascicularis of rat thalamus].
abstract: Glass microelectaod recording method was used to investigate the effect of thyrotropin-releasing hormone (TRH) into nucleus accumbens, nucleus amygdaloid or nucleus caudate-putamen on unit discharges of pain-excitation neurons (PEN) in nucleus parafascicularis of thalamus in rats. The results showed that: (1) TRH injected into the nucleus accumbens results in a significant inhibition of pain discharges of PEN in nucleus parafascicularis. But injection of TRH into nucleus amygdaloid, nucleus caudate-putamen had no significant effect. (2) Pretreatment with auropine abolished the inhibitory effect of TRH. (3) Pretreatment with haloperidol also abolished the inhibitory effect of TRH. (4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH. The results mentioned above suggested that nucleus accumbens could be a special area in response to TRH and the effect of TRH seems to be involved in both cholinergic M-receptor and dopamine receptor.
authors: Department of Physiology, Tong-Ji Medical University.
authors: Z
authors: Z
authors: Nie
authors: Z
authors: Z
authors: Liu
mesh_terms: D000679:Amygdala / Q000502:physiology; D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009619:Nociceptors / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012684:Sensory Thresholds; D013787:Thalamic Nuclei / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
chemical_list: D013973:Thyrotropin-Releasing Hormone