The effect of haemodialysis on tubular secretion of creatinine in residual nephrons.
In a group of 16 patients on regular haemodialysis treatment, inulin and creatinine clearance was examined before and 12 h after haemodialysis. Inulin clearance (CIn) decreased significantly (P less than 0.001) whereas creatinine clearance (CCr) did not change after haemodialysis. The CCr/CIn ratio increased significantly (P less than 0.05) as did calculated tubular secretion of creatinine (TCr) (P less than 0.01) and TCr/CIn 100 (P less than 0.001). The results suggest that uraemic sera contain dialysable substance(s) depressing tubular secretion of creatinine.
Schück
O
O
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Taplan
V
V
Nádvorníková
H
H
D003404:Creatinine / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007444:Inulin / Q000097:blood; D007684:Kidney Tubules / Q000378:metabolism*; D009399:Nephrons / Q000378:metabolism*; D006435:Renal Dialysis
D007444:Inulin; D003404:Creatinine