TF1, a bacteriophage-specific DNA-binding and DNA-bending protein.
We review and discuss the biological and DNA-binding properties of the bacteriophage SPO1 transcription factor 1 (TF1), a DNA-binding protein belonging to the ubiquitous prokaryotic family of Type II DNA-binding proteins. We review recent information on the effects of certain mutations in TF1 on DNA-binding and on its ability to sharply bend DNA. We also compare the DNA-binding properties of the three best-studied type II DNA-binding proteins, Escherichia coli HU, E. coli integration host factor, and TF1, and discuss them in the context of the structure and properties of chromatin in prokaryotes.
Geiduschek
E P
EP
Department of Biology, University of California, San Diego, La Jolla 92093.
Schneider
G J
GJ
Sayre
M H
MH
D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D004926:Escherichia coli / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins
D004268:DNA-Binding Proteins; C059361:TF1 DNA-binding protein, Bacteriophage SPO1; D014764:Viral Proteins