Effects of temperature and osmolality on the release of atrial natriuretic peptide.
In isolated rat atria a 10 degrees C increase in temperature approximately doubled the output of atrial natriuretic peptide during relaxation and stretch. The effect was not due to the increased rate of contraction. Increasing the osmolality of the superfusate within the physiological range (290 to 320 m osmols) with sodium, potassium or glucose had no appreciable effect on the release of atrial natriuretic peptide.
Agnoletti
G
G
Cattedra di Cardiologia, Universita' di Brescia, Italy.
Cornacchiari
A
A
Ferrari
R
R
Harris
P
P
D000818:Animals; D016275:Atrial Function; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate; D006982:Hypertonic Solutions; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction; D009994:Osmolar Concentration; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D013696:Temperature
D006982:Hypertonic Solutions; D012965:Sodium Chloride; D011189:Potassium Chloride; D009320:Atrial Natriuretic Factor; D005947:Glucose