Sporicidal action of alkaline glutaraldehyde: factors influencing activity and a comparison with other aldehydes.
The sporicidal efficacy of glutaraldehyde (2% w/v) was investigated under various conditions. Numerous factors influenced its activity: method of spore production, inherent spore resistance characteristics, alkalination, storage time and storage temperature. The sporicidal action of 2% alkaline glutaraldehyde at room temperature was compared with that of other aldehydes and commercially available formulations. Cidex (glutaraldehyde) and Sporicidin (glutaraldehyde + phenol full strength) were the most effective, followed by 8% (w/v) formaldehyde and 10% (v/v) Gigasept, a formaldehyde-containing product. Five per cent (v/v) Gigasept and 10% (w/v) glyoxal also had good sporicidal activity, though that of Sporicidin (1:16) was poor. No activity was observed with 10% (w/v) butyraldehyde.
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Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
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D000447:Aldehydes / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D004355:Drug Stability; D005976:Glutaral / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013171:Spores, Bacterial / Q000187:drug effects
D000447:Aldehydes; D012996:Solutions; D005976:Glutaral