[Maternal influence on susceptibility to cleft palate (1)].
We studied the effect of nonsteroid antiinflammatory (Indomethacin, R), in the palate fusion of rat embryos from different strains with variable susceptibility and also the influence of glucocorticoids. Indomethacin inhibits the fusion of the palate process with variable rate depending of the rat strain. In reciprocal inbred we observed that the effect is greater in embryo from susceptible females than from resistant females. This demonstrates that there are a maternal influence in the induction of cleft palate due to Indomethacin.
Palomino
H M
HM
Facultad de Odontologia, Universidad de Chile.
Peredo
M T
MT
Montenegro
M A
MA
D000818:Animals; D016009:Chi-Square Distribution; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D007213:Indomethacin / Q000633:toxicity*; D008285:Major Histocompatibility Complex; D008297:Male; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity
D007213:Indomethacin
Influencia materna en la susceptibilidad a la fisura palatina (1).