The thoracoabdominal syndrome (TAS): a new X-linked dominant disorder.
We report on a family with a previously undescribed malformation syndrome. The syndrome is composed of diaphragmatic and ventral herniae, hypoplastic lung, and associated cardiac anomalies. The relative number of affected males and females and appreciably severer manifestations in males suggest an X-linked dominant inheritance.
Carmi
R
R
Clinical Genetic Unit, Soroka University Hospital, Beer-Sheva, Israel.
Barbash
A
A
Mares
A J
AJ
D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006548:Hernia, Diaphragmatic / Q000235:genetics; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000002:abnormalities; D008297:Male; D010375:Pedigree; D013577:Syndrome; D013909:Thorax / Q000002:abnormalities*; D014960:X Chromosome