title: [The testing for carcinogenicity of a polyethylene terephthalate vascular prosthesis].
abstract: A long-term for possible carcinogenicity was conducted by subcutaneous implantation of 1 cm 2 pieces of polyethylenetherophthalate vascular grafts (PET-VG) to 150 BDF1 mice and 120 Syrian golden hamsters of either sex. A false operation was carried out in the same number of animals of control groups. Implantation was performed in nine-week-old animals. The observation period was 73 weeks for mice and 82 weeks for hamsters. A total of 161 tumors (81 in the experimental group) with 15 localizations were observed in mice and 43 tumors (20 in the experimental group) with 13 localizations--in hamsters. No pathological or statistical evidence of induction of tumors by PET-VG was found. It is concluded that under the conditions of this study PET-VG is not carcinogenic for BDF1 mice and Syrian golden hamsters of either sex.
authors: P
authors: P
authors: Blagoeva
authors: I
authors: I
authors: Stoĭchev
authors: R
authors: R
authors: Balanski
authors: L
authors: L
authors: Pŭrvanova
authors: T S
authors: TS
authors: Mircheva
authors: A
authors: A
authors: Smilov
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D011093:Polyethylene Terephthalates / Q000633:toxicity*; D019736:Prostheses and Implants; D013997:Time Factors
chemical_list: D011093:Polyethylene Terephthalates
vernacular_title: Testirovane na kantserogennost na polietilentereftalova sŭdova proteza.