[Dynamics of the antibody response and p24 antigenemia in HIV-1 infected individuals in Czechoslovakia].
In a group of 83 anti HIV-1 positive subjects the antibody response against different structural viral proteins was investigated concurrently with assessment of p 24 antigenaemia. Disappearance of antibodies against the capsidal antigen p 24 was recorded in 12% of 42 patients with ARC and AIDS. On the other hand, these antibodies persisted in all 41 asymptomatic infections throughout the three-year investigation period. Disappearance of antibodies against p 17 antigen was proved in 41% of the patients and in 22 subjects without clinical symptoms. The authors found a rising trend of antigenaemia p 24 in the course of HIV infection. The free p 24 antigen was detected in 62% patients with AIDS and only in 10% asymptomatic infections. The investigation confirmed the importance of investigations of the antibody response and p 24 antigenaemia in the prognosis of development of HIV infection and in monitoring of the effect of therapy.
Kopecká
D
D
Institut hygieny a epidemiologie, Praha.
Brůcková
M
M
Stanková
M
M
Syrůcek
L
L
Vojtĕchovský
K
K
Petkov
V
V
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D015683:Gene Products, gag / Q000032:analysis*; D015483:HIV Antibodies / Q000032:analysis*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D010455:Peptides / Q000032:analysis; D014758:Viral Core Proteins / Q000032:analysis*; D054301:gag Gene Products, Human Immunodeficiency Virus
D015683:Gene Products, gag; C052407:HGP-30 peptide, Human immunodeficiency virus-1; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D010455:Peptides; D014758:Viral Core Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus
Dynamika protilátkové odpovĕdi a p 24 antigenémie u HIV-1 infikovaných osob v CSR.