Homologous Robertsonian translocation (21q21q) and abortions.
Instances of balanced Robertsonian translocations between the homologues of chromosome 21 were observed in two couples with a history of repeated abortions. The male partner of one couple and the female partner of another couple exhibited this anomaly. The translocation (21q21q) was found to be transmitted to their live children with Down's syndrome.
Sudha
T
T
Department of Genetics, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
Gopinath
P M
PM
D000026:Abortion, Habitual / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic