[Medicamentous cardioprotection. 2: Hypertension].
Coronary heart diseases are three times more common in hypertensives older than 65 than in normotensive patients with comparable risk profiles. To be effective, cardioprotection must cover both elevated blood pressure and its consequences for the myocardium and coronary vessels (myocardial hypertrophy, microangiopathy and macroangiopathy), and should employ substances that have an effect on the underlying pathophysiological processes of hypertension and hypertensive cardiopathy. These preconditions are, at least in part, met by calcium antagonists, ACE-inhibitors and beta blockers. They have been proved to bring about a lasting decrease in blood pressure, and regression of cardiac enlargement. Regression of coronary sclerotic changes, however, is not yet certain. Overadditive effects have been described for the combination of calcium antagonists and ACE-inhibitors.
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D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000517:prevention & control*; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012307:Risk Factors
D000959:Antihypertensive Agents
Medikamentöse Kardioprotektion. Teil 2: Hypertonie.