Transient effect on mannitol on cerebral blood flow following brain injury.
CBF and ICP were measured in cats following cerebral cold injury and mannitol infusion. Mannitol was found to reduce the intracranial hypertension caused by the injury. The restoration of CBF and ICP was of short duration and was followed by a reduction of CBF and elevation of ICP. A repeated restoration of CBF by a second dose of mannitol was followed by a more severe impairment of CBF. The prolonged beneficial effect of mannitol on CBF after brain injury has to be reassessed.
Shalmon
E
E
Department of Neurosurgery, Experimental Research Laboratory, Beilinson Medical Center, Petah Tiqva, Israel.
Reichenthal
E
E
Kaspi
T
T
D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003080:Cold Temperature; D007427:Intracranial Pressure / Q000187:drug effects; D008353:Mannitol / Q000494:pharmacology*
D008353:Mannitol