The mitochondrial genome: a possible primary site of action of steroid hormones.
Sequences showing partial homology to glucocorticoid and estrogen responsive elements have been detected in the human and mouse mitochondrial genome. Considering the well established role of hormone responsive elements in steroid hormone action, it is postulated that the mitochondrial genome could be a primary site of action of steroid hormones.
Sekeris
C E
CE
Biological Research Center, National Hellenic Research Foundation, Athens, Greece.
D000818:Animals; D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005796:Genes; D005938:Glucocorticoids / Q000494:pharmacology; D006728:Hormones / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D011247:Pregnancy
D004272:DNA, Mitochondrial; D005938:Glucocorticoids; D006728:Hormones