Separation of antibiotics by autofocusing.
The autofocusing separation of nine antibiotics was investigated: tetracycline and chloramphenicol in large-scale batches, and seven others in gram preparation amounts. All except one were found to be heterogeneous in autofocusing, and 2-4 well-characterized fractions emerged. These heterogeneities are described and the industrial utilization of the procedure is suggested.
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Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Czech and Slovak Federative Republic.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D013293:Enterococcus faecalis / Q000032:analysis; D004926:Escherichia coli / Q000032:analysis; D007525:Isoelectric Focusing / Q000379:methods*; D013294:Lactococcus lactis / Q000032:analysis
D000900:Anti-Bacterial Agents