Lamotrigine protects against kainate but not ibotenate lesions in rat striatum.
Pretreatment of rats with 8-16 mg/kg of lamotrigine 1 h before intrastriatal injections of 2 nm of kainic acid significantly attenuated the neurotoxicity as evidenced by measurements of striatal choline acetyltransferase and glutamate decarboxylase activities. No significant effect was seen on the toxicity of intrastriatal injections of quinolinic acid or ibotenic acid. These differential effects are further evidence that these neurotoxins act at different excitatory amino acid receptors and that the neurotoxicity of kainate is uniquely dependent on neuronally released glutamate.
McGeer
E G
EG
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Zhu
S G
SG
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007051:Ibotenic Acid / Q000633:toxicity; D007608:Kainic Acid / Q000633:toxicity*; D000077213:Lamotrigine; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D014227:Triazines / Q000494:pharmacology*
D000927:Anticonvulsants; D009498:Neurotoxins; D011805:Quinolinic Acids; D014227:Triazines; D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D017378:Quinolinic Acid; D007608:Kainic Acid; D000077213:Lamotrigine