[Combined therapy, oral hypoglycemic agent and low-dose insulin, in type 2 diabetes mellitus in secondary failure: a year's experience].
We have evaluated, for a period of 12 months, the response to the combined therapy with oral hypoglycaemic agents and insulin at low doses in a group of 21 patients with type 2 diabetes mellitus in secondary failure. A clear improvement of the parameters considered (fasting and postprandial glycaemia, glycated haemoglobin) was obtained, while maintaining the endogenous secretion of insulin. Important side effects were not observed and the increases of body weight and insulin dose registered in the course of one year were of minor importance.
Mainini
E
E
Divisione di Endocrinologia e Medicina Costituzionale, U.S.L. N. 6, Ospedale S. Antonio Abate, Gallarate (Varese).
Martinelli
I
I
Morandi
G
G
Mazzi
C
C
D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin
Terapia combinata, ipoglicemizzante orale e insulina a basso dosaggio, nel diabete mellito tipo 2 in fallimento secondario: un anno di esperienza.