Renal disposal of human atrial natriuretic peptide in man.
In healthy men (n = 7) the renal fractional extraction of human atrial natriuretic factor (hANP) as determined by the renal venous catheter technique was approximately 50% both under basal conditions and during the administration of exogenous hANP. When arterial and venous plasma concentrations of hANP were maintained about tenfold above basal concentrations by a bolus- (100 micrograms) primed intravenous (IV) infusion (100 micrograms/h for 1 hour) of hANP, renal uptake of hANP increased from, basal, 11.2 +/- 6.7 pmol/min to 126.5 +/- 64.8 pmol/min (P less than .05), while estimated renal plasma flow (ERPF) decreased by about 25% (P less than .05). Total metabolic clearance rates (MCRs) of hANP, renal clearance rates, and production rates of hANP were 3.89 +/- 1.21 L/min, 0.42 +/- 0.18 L/min, and 76.1 +/- 52.7 pmol/min, respectively. In healthy men, one kidney accounts for about 10% of total hANP clearance.
Vierhapper
H
H
Division of Clinical Endocrinology and Diabetes Mellitus, I. Medizinische Universitätsklinik, Wien, Austria.
Gasic
S
S
Nowotny
P
P
Waldhäusl
W
W
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008657:Metabolic Clearance Rate; D012016:Reference Values; D012079:Renal Circulation
D009320:Atrial Natriuretic Factor