Genetic control of delayed type hypersensitivity to Mycobacterium leprae antigen.
The mechanism of genetic control of Mycobacterium leprae-specific delayed type hypersensitivity (DTH) in mice was investigated in terms of footpad swelling response. Studies with various congenic and recombinant inbred strains of mouse revealed that M. leprae-specific DTH was controlled by genes within the I-A subregion. The footpad swelling response showed an antigen-specific pattern, revealing that M. leprae antigen was not cross-reactive with M. tuberculosis antigen. Treatment of immune lymphoid cells with monoclonal antibodies plus complement revealed that the cells responsible for DTH transfer were Lyt-2-, L3T4+ T cells. Suppressor T cell activity was not detected in low-responder mice.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Nakajima
H
H
Aoki
I
I
Shimoda
N
N
Mori
T
T
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D006239:Haplotypes; D006968:Hypersensitivity, Delayed / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009166:Mycobacterium leprae / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial