Effect of cyclosporin A on suppressor T cells.
The effect of cyclosporin A (CsA) on suppressor T cells (Ts) was evaluated by in vitro incubation with afferent-phase Ts (Ts-aff) and efferent-phase Ts (Ts-eff). 2,4-Dinitro-1-fluorobenzene (DNFB) and hen egg-white lysozyme (HEL) were used as antigens. Both Ts-aff and Ts-eff were resistant to high- and low-dose CsA treatments. However, T cells associated with delayed type hypersensitivity (DTH) [TDTH] to DNFB or HEL were sensitive to these CsA treatments. These results indicate that the effect of CsA treatment on contact sensitivity and DTH influences TDTH and not Ts.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Ishii
H
H
Ono
H
H
Horiuchi
Y
Y
Nakajima
H
H
Aoki
I
I
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000503:physiopathology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000473:pathology; D051379:Mice; D009113:Muramidase / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000502:physiology
D003524:Cyclosporins; D004139:Dinitrofluorobenzene; D009113:Muramidase