Immunohistochemical aspects of acute rejection of the allografted rat lung.
We studied changes in the relative proportions of lymphocyte subsets infiltrating RT1-incompatible transplanted rat lungs during acute rejection. Lungs were examined at different times after transplantation with immunohistochemical staining. In the perivascular and peribronchial region, the ratio of helper to cytotoxic-suppressor T cells was reversed on day 4 when cytotoxic-suppressor T cells became most abundant. In the alveolar region, cytotoxic-suppressor T cells were more abundant than helper T cells from day 3. This rapid change in the proportion of T cell subsets has not been reported for other organ transplants. It may explain why lung allografts are rejected more rapidly than other organs.
Yamamoto
R
R
Second Department of Surgery, Osaka City University Medical School, Japan.
Kinoshita
H
H
Kinoshita
Y
Y
Mizoguchi
S
S
Inoue
K
K
Kishi
A
A
D000818:Animals; D006084:Graft Rejection; D007958:Leukocyte Count; D008168:Lung / Q000276:immunology / Q000473:pathology; D016040:Lung Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology