[Sensitivity curves of multiply resistant corynebacteria JK and D2].
Corynebacteria groups JK and D2 are opportunistic pathogens. They are sometimes responsible for severe infections, especially in immunocompromised patients. They are resistant to many antibiotics. Under these conditions it seemed important to discover which antibiotics among those regularly active, have a killing effect, what their bactericidal speed is, and how they react to combination with other antibiotics. Glycopeptids have a killing effect within 24 hours. Pristinamycin, rifampin, fusidic acid, when active, are bacteriostatic. Their combination with vancomycin is indifferent but in one case the combination vancomycin + rifampin is synergistic.
Rauturier
M
M
Laboratoire de Bactériologie, Hôpital Lapeyronie, Montpellier.
Darbas
H
H
Jean-Pierre
H
H
Boyer
G
G
Rivière
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003352:Corynebacterium / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology; D066298:In Vitro Techniques; D012293:Rifampin / Q000494:pharmacology; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin; D012293:Rifampin
Vitesses de bactéricidie chez les corynébactéries JK et D2 multirésistantes.