Enhanced rate of cortical spreading depression due to malnutrition: prevention by dietary protein supplementation.
The enhanced propagation rate of cortical spreading depression, observed previously in rats rendered malnourished by the regional basic diet that is typical of the daily fare of many of the inhabitants of the northeastern region of Brazil, was not prevented by raising the quantity of dietary protein to the normal level without changing its quality. Dietary supplementation with casein, a protein of good quality, however, abolished the effect on spreading depression. These data indicate that the quality, and not the quantity, of the dietary protein is the critical factor in reversing the effects of regional basic diet malnutrition on spreading depression.
Andrade
A F
AF
Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, Brasil.
Guedes
R C
RC
Teodósio
N R
NR
D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D013181:Cortical Spreading Depression; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D008297:Male; D011502:Protein-Energy Malnutrition / Q000517:prevention & control*; D051381:Rats
D002364:Caseins; D004044:Dietary Proteins