Primary platelet activation in recent-onset type 1 diabetes mellitus.
Platelet function (as production of thromboxane B2 by platelets stimulated with collagen, and plasma beta-thromboglobulin) and thrombin activity (as plasma fibrinopeptide A) were investigated in eight young (mean age 27 +/- 3 SE years) male patients in which type 1 diabetes mellitus had been diagnosed 2 to 6 months previously. They were all in excellent stable metabolic control (mean HbA1c 5.6 +/- 0.4 SE %) and free from any complications. The haemostatic variables were assessed at rest and after cycloergometric exercise to exhaustion. When compared to age- and sex-matched healthy controls, patients showed higher beta-thromboglobulin, fibrinopeptide A and thromboxane B2 at rest. After exercise, plasma beta-TG increased only in the controls. Platelet and thrombin activation are present in the very early stages of type 1 diabetes mellitus, in the absence of any complications.
Vicari
A M
AM
Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy.
Macagni
A
A
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003094:Collagen / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D015444:Exercise / Q000502:physiology; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D008297:Male; D015539:Platelet Activation; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D013929:Thromboxane B2; D003094:Collagen