[Stabilization of lung function in cystic fibrosis during long-term tube feeding via a percutaneous endoscopic gastrostomy].
To determine whether long-term enteral feedings can improve nutritional status and lung function parameters in patients with cystic fibrosis (CF), 11 patients (8 female, 3 male, age 7 to 23 years) received a percutaneous endoscopic gastrostomy (PEG) since February 1988. All patients were moderately to severely affected and extremely malnourished with a relative underweight of 15% or more. After 9 months of supplemental nocturnal feeding, mean body weight improved from 25.8 +/- 4.7 kg (mean, standard deviation) to 31.6 +/- 7.4 kg (p = 0.003); mean relative underweight decreased from 20.7 +/- 3.4% to 10.4 +/- 8.6% (p = 0.02). Lung function, which was measured either prior to or without any intravenous antibiotics, improved considerably: mean vital capacity increased from 39.5% of the predicted value to 46.8% after 9 months (p = 0.01), the mean peak flow rate improved from 39.5% to 50.8% (p = 0.01). This improvement in lung function is probably secondary to the increased muscle mass of the patients. Long-term nocturnal feedings via a percutaneous gastrostomy tube improve nutritional status and lung function severely in malnourished patients with CF.
Steinkamp
G
G
Kinderklinik der Medizinischen Hochschule Hannover.
Rodeck
B
B
Seidenberg
J
J
Rühl
I
I
von der Hardt
H
H
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology* / Q000628:therapy; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005774:Gastrostomy; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009752:Nutritional Status; D012129:Respiratory Function Tests
Stabilisierung der Lungenfunktion bei zystischer Fibrose durch Langzeitsondenernährung über eine perkutane endoskopische Gastrostomie.