Elevation of facilitated glucose-transporter messenger RNA in human hepatocellular carcinoma.
Complementary DNA of a rat brain glucose transporter gene was used to examine the expression of glucose-transporter messenger RNA in paired human hepatocellular carcinomas and adjacent nontumorous liver tissues, as well as in human hepatoma cell lines and human fetal liver samples. High expression of a major 2.8-kilobase glucose-transporter transcript was seen in all hepatoma cell lines and fetal liver samples examined, whereas a much lower level of expression was observed in liver tissues. When pairs of liver tissues were examined, elevation of glucose-transporter RNA levels was observed in most of the hepatocellular carcinoma tissues examined.
Su
T S
TS
Department of Medical Research, Veterans General Hospital, Taiwan, Republic of China.
Tsai
T F
TF
Chi
C W
CW
Han
S H
SH
Chou
C K
CK
D000818:Animals; D015152:Blotting, Northern; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism; D015342:DNA Probes; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000032:analysis*; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000032:analysis; D009857:Oncogenes; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000032:analysis
D015342:DNA Probes; D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger