Immune response to collagen impregnated Dacron double velour grafts for aortic and aorto-femoral reconstructions.
This study presents 20 patients, randomised to receive either a collagen-treated or an ordinary Dacron graft for aortic reconstructions, and the results of a skin-prick test, blood parameters and ELISA for anti-collagen antibodies as well as NMR pictures during a 6 week follow-up period. Forty per cent (4/11) of those receiving a collagen impregnated graft had a significantly increased titre of antibodies and NMR revealed in two out of 11 patients either a slightly increased amount of fluid or fibrosis around the graft, both collagen impregnated. No differences were found between the graft groups concerning body temperature and leucocyte or platelet counts. The skin-prick test for collagen was negative in all cases.
Norgren
L
L
Department of Surgery, Lund University, Sweden.
Holtås
S
S
Persson
G
G
Ribbe
E
E
Saxne
T
T
Thörne
J
J
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D001011:Aorta / Q000473:pathology / Q000601:surgery*; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000601:surgery*; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000601:surgery*; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D016032:Randomized Controlled Trials as Topic; D012882:Skin Tests
D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D003094:Collagen