title: Chromosomal abnormalities define clonal proliferation in CD3- large granular lymphocyte leukemia.
abstract: Six patients with lymphoproliferative disorder of large granular lymphocytes (LDGL) were studied for chromosomal abnormalities. When the patients were divided into two groups depending on the expression of a mature antigen of T cell lineage, CD3, two with CD3+ phenotype had a stable disease, whereas three of the four patients with CD3- phenotype had marked hepatosplenomegaly and a highly aggressive disease. Chromosomal abnormalities were detected in four of six patients, indicating a clonal proliferation of large granular lymphocytes in individual patients. In particular, chromosomal abnormalities were found in three of the four patients with CD3- LDGL, all of which had a germ-line configuration of the T cell receptor beta-chain gene. Thus, the chromosomal abnormalities provide definitive evidence for the clonal origin of the expanded cells in the CD3- LDGL.
authors: Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
authors: M
authors: M
authors: Taniwaki
authors: S
authors: S
authors: Tagawa
authors: H
authors: H
authors: Nishigaki
authors: S
authors: S
authors: Horiike
authors: S
authors: S
authors: Misawa
authors: C
authors: C
authors: Shimazaki
authors: T
authors: T
authors: Maekawa
authors: H
authors: H
authors: Fujii
authors: T
authors: T
authors: Kitani
authors: T
authors: T
authors: Abe
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D017252:CD3 Complex; D002869:Chromosome Aberrations / Q000473:pathology; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology* / Q000502:physiology; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000473:pathology; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000032:analysis* / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta