title: Buspirone/prolactin response in post head injury depression.
abstract: Fifty-five male patients who had suffered a mild head injury 11-13 months previously were investigated for evidence of depression. Eleven were diagnosed as DSM-III major depressives, nine with melancholia. Prolactin response to buspirone was examined in these patients, in eight male head-injured patients without depression and 10 age-matched male healthy controls. The prolactin response was significantly blunted in post head injury depressed patients compared to head injury non-depressed and healthy control groups. We suggest that these differences may be due to altered serotonin functioning post head injury.
authors: Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin, Ireland.
authors: M
authors: M
authors: Mobayed
authors: T G
authors: TG
authors: Dinan
mesh_terms: D000328:Adult; D000368:Aged; D001924:Brain Concussion / Q000150:complications*; D002065:Buspirone; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D010556:Personality Tests; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales
chemical_list: D011388:Prolactin; D002065:Buspirone