title: Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control.
abstract: We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.
authors: University Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne, UK.
authors: G
authors: G
authors: Hall
authors: M J
authors: MJ
authors: Lind
authors: M
authors: M
authors: Huang
authors: A
authors: A
authors: Moore
authors: A
authors: A
authors: Gane
authors: J T
authors: JT
authors: Roberts
authors: B M
authors: BM
authors: Cantwell
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000517:prevention & control; D004347:Drug Interactions; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008297:Male; D015080:Mesna / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D014859:Warfarin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014859:Warfarin; D015080:Mesna; D007069:Ifosfamide