[Laser-induced fluorescence diagnosis of tumors exemplified by solid Ehrlich carcinoma].
The laser-induced fluorescence of hematoporphyrin derivative (HpD) sensitized experimental Ehrlich carcinoma on mice is investigated. The fluorescence is excited with the 364-nm argon laser line. The tumor fluorescence spectra are recorded in the red spectral region. The HpD induced fluorescence of the tumors is superimposed on the autofluorescence of tissue. The tumor fluorescence shows a maximum 4 h after i.p. application of HpD. The fluorescence intensity is reduced by strong excitation causing bleaching of the HpD absorption. The fluorescence spectrum is also changing and the generation of a fluorescent photoproduct is observed.
König
K
K
Sektion Physik der Friedrich-Schiller-Universität Jena.
Dietel
W
W
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000175:diagnosis*; D005260:Female; D005453:Fluorescence; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins; D007834:Lasers; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors; D014466:Ultraviolet Rays
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative
Laserinduzierte Tumor-Fluoreszenzdiagnostik am Beispiel des soliden Ehrlichkarzinoms.