The oxidative phenotype as a marker of individual predisposition to neoplasm induced by chemical carcinogens.
The authors present a review of literature showing that the variations in xenobiotic oxidation phenotype, in the presence of cytochromes P-450, may be responsible, to a certain extent, for the varied individual susceptibility to neoplasm induced by chemical carcinogens. The evidence collected revealed that in the human population, one may distinguish individuals with high cytochrome activity and those in whom this reaction is low or even absent.
Lutz
W
W
Department of Laboratory Diagnostics, Nofer Institute of Occupational Medicine, Lodz, Poland.
Sułkowski
W
W
D014408:Biomarkers, Tumor / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D010084:Oxidation-Reduction; D010641:Phenotype; D011083:Polycyclic Compounds / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D014158:Transcription, Genetic / Q000502:physiology
D014408:Biomarkers, Tumor; D011083:Polycyclic Compounds; D003577:Cytochrome P-450 Enzyme System