[Immunosuppressive effect of cyclosporin A incapsulated into liposomes].
A preparation of cyclosporine A (CsA) in small liposomes (300 nm) was tested in a rat model of heterotopic cardiac allograft. At a daily dose of 1,5 mg/kg during 14 days, the graft survival rate was 30.4 +/- 2.8 days with a liposome-CsA solution versus 16 +/- 2.3 days with a Cremophore-CsA solution (p less than 0.01). Animals treated with the liposome-CsA preparation exhibited less weight loss than animals treated with cremophore-CsA solution (p less than 0.01). It is likely that the up-take of CsA by macrophages, when incapsulated into liposomes is dramatically enhanced; these cells have been pointed out at targets for IL2 inhibition by CsA.
Arnoux
R
R
Clinique chirurgicale du C.H.R., Bordeaux.
Dufourcq
J
J
Smeesters
C
C
Lalanne
J
J
Deminière
C
C
Penin
E
E
Clerc
M
M
Poteaux
L
L
Dartigues
J F
JF
Michel
A
A
D000818:Animals; D001835:Body Weight; D003524:Cyclosporins / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D007108:Immune Tolerance / Q000187:drug effects*; D008081:Liposomes; D008264:Macrophages; D010587:Phagocytosis; D011092:Polyethylene Glycols; D051381:Rats; D012997:Solvents; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes; D012997:Solvents; C022131:cremophor; D011092:Polyethylene Glycols
Effet immunosuppresseur de la cyclosporine A incorporée dans les liposomes.