Pure red-cell aplasia of long duration after major ABO-incompatible bone marrow transplantation.
We describe a patient with an exceptionally long-lasting red-cell aplasia of 330 days following ABO-incompatible bone marrow transplantation (BMT). Before BMT, the anti-B titre was high, 1:1,024, and it was only temporarily reduced by extensive plasma exchange. The anti-B titre remained above the level of 1:64 for 270 days, and host-derived isoagglutinin could still be detected 3 years after BMT. In vitro bone marrow cultures during the red-cell aplasia showed greatly reduced numbers or total absence of CFU-E, while the number of BFU-E colonies was only moderately subnormal. Six years after BMT, bone marrow and peripheral-blood cell counts are normal.
Volin
L
L
Third Department of Medicine, University of Helsinki, Finland.
Ruutu
T
T
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000276:immunology / Q000628:therapy; D010951:Plasma Exchange; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000276:immunology; D012156:Reticulocytes / Q000276:immunology; D013997:Time Factors
D000017:ABO Blood-Group System