[Recurrent post-infectious immune complex glomerulonephritis with persistent activation of the alternative complement pathway].
Recurring upper respiratory tract infections in a previously healthy 4 years old boy led to an acute nephritic syndrome requiring haemodialysis. Renal biopsy showed poststreptococcal like immune complex glomerulonephritis with subepithelial humps, C3 deposition and crescent formation. Renal function improved after methyl-prednisolone pulse therapy. Two relapses occurred in the following six months which responded to immunosuppressive therapy. 21 months following the first presentation the boy has normal glomerular filtration rate but persistent glomerular proteinuria and haematuria. Detailed complement analyses revealed a persistent activation of the alternate pathway.
Arslan-Kirchner
M
M
Kinderklinik, Medizinischen Hochschule Hannover.
Ehrich
J H
JH
Kirschfink
M
M
Helmchen
U
U
Brodehl
J
J
D002675:Child, Preschool; D003167:Complement Activation / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis*; D003178:Complement C3 Nephritic Factor / Q000032:analysis; D015933:Complement C3d / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003170:Complement Pathway, Alternative / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007677:Kidney Function Tests; D008297:Male; D013290:Streptococcal Infections / Q000276:immunology*
D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D015933:Complement C3d
Rezidivierende postinfektiöse Immunkomplex-Glomerulonephritis mit persistierender Aktivierung des alternativen Komplementwegs.