Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage phi X174.
The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetriester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyoxymethyl)-benzoyl for the masking of the N6-amino function of deoxyadenosine. The latter protecting group can be removed under mild conditions with fluoride ion.
Dreef-Tromp
C M
CM
Gorlaeus Laboratories, Leiden, The Netherlands.
van Dam
E M
EM
van den Elst
H
H
van der Marel
G A
GA
van Boom
J H
JH
D010584:Bacteriophage phi X 174 / Q000032:analysis; D002845:Chromatography; D009698:Nucleoproteins / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis*
D009698:Nucleoproteins; D009842:Oligopeptides