[Vasodilator effect of benzothiadiazine derivative, LN 5330, on rat pancreatic vessels].
The effect of a benzothiadiazine derivative LN 5330, structurally related to diazoxide, was investigated on the vascular flow rate of the isolated perfused rat pancreas. LN 5330 induced a progressive increase of the vascular flow rate, which lasted throughout the infusion. This effect was dose-dependent between 10(-5) and 10(-4) M. LN 5330 was seven times less potent than diazoxide at increasing the flow rate. These results show that LN 5330 has a vasodilator effect on pancreatic vascular bed, and is less potent than its structural analogue diazoxide.
Petit
P
P
Laboratoire de Pharmacologie, URA 599 du CNRS, Faculté de Médecine, Montpellier.
Hillaire-Buys
D
D
Blayac
J P
JP
Loubatières-Mariani
M M
MM
D000818:Animals; D003981:Diazoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D010179:Pancreas / Q000098:blood supply* / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D003981:Diazoxide
Effet vasodilatateur d'un dérivé de la benzothiadiazine, le LN 5330, sur les vaisseaux pancréatiques de rat.