Adrenal medullary graft to brain in 6-hydroxydopamine-lesioned rotation rats. Comparison of two different graft sites (striatum versus lateral ventricle) by behavioral observation and fluorescence histochemistry.
Using 6-hydroxydopamine-lesioned rotation rats as a model of Parkinson's disease, an investigation was made of the optimal site for transplantation of adrenal medulla. One site was selected in the striatum (striatum group) and one in the lateral ventricle close to the striatum (lateral ventricle group). 6 weeks after grafting, the rotational behavior in the striatum and ventricle group was reduced by 43% (p less than 0.01) and 35% (p less than 0.01), respectively, as compared to the control group. 12 weeks after grafting, these figures were 30% (p less than 0.05) and 17% (n.s.). The striatum was slightly superior to the lateral ventricle as the site for transplantation.
Torigoe
R
R
Department of Neurosurgery, Hakujikai Memorial Hospital, Tokyo, Japan.
Yoshida
M
M
Ohtsuru
K
K
Kuga
S
S
Kuramoto
S
S
D000313:Adrenal Medulla / Q000637:transplantation*; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000601:surgery*; D003342:Corpus Striatum / Q000187:drug effects / Q000601:surgery*; D006085:Graft Survival / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008856:Microscopy, Fluorescence; D009043:Motor Activity / Q000187:drug effects; D009416:Nerve Regeneration / Q000502:physiology; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D013239:Stereotyped Behavior / Q000187:drug effects*
D006892:Hydroxydopamines; D016627:Oxidopamine