title: LAK activity is inducible in blood mononuclear cells from human fetus.
abstract: Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.
authors: Chair of Immunology, University of Modena, Italy.
authors: A
authors: A
authors: Cossarizza
authors: D
authors: D
authors: Monti
authors: F
authors: F
authors: Dagna-Bricarelli
authors: G
authors: G
authors: Montagnani
authors: C
authors: C
authors: Franceschi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002469:Cell Separation; D003602:Cytotoxicity, Immunologic; D004314:Down Syndrome / Q000196:embryology / Q000276:immunology*; D005333:Fetus / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000187:drug effects*
chemical_list: D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D007376:Interleukin-2