Suppressor cells induced by influenza virus inhibit interleukin-2 production in mice.
PR8 virus depressed interleukin-2 (IL-2) and natural killer (NK) cell activity in BALB/c infected mice. IL-2 production was not dependent on (i) a decreased number of T cells or (ii) a primary defect in IL-1 production, but on a T-suppressor cell subpopulation. In fact, when T suppressor cells were removed from infected spleen cells, we observed normal levels of IL-2 activity.
Del Gobbo
V
V
Department of Experimental Medicine, II University of Rome, Italy.
Villani
N
N
Marini
S
S
Balestra
E
E
Caliò
R
R
D000818:Animals; D007376:Interleukin-2 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000502:physiology; D008212:Lymphocyte Depletion; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D007376:Interleukin-2