Effect of lithium on the dynamics of electroencephalographic vigilance in healthy subjects.
Eleven healthy male volunteers had EEG recordings before lithium, after 10 days of lithium administration and 2 weeks after discontinuation of lithium. As postulated from previous investigations the typical lithium effect on the dynamics of electroencephalographic vigilance proved to consist of: (1) a decrease of non-alpha segments, i.e., an increase of alpha continuity or an enhancement of alpha activity; (2) an increase of the anterior/posterior ratio of absolute alpha power (AQ); (3) a decrease of the dynamic variability of this alpha anteriorization (CV-AQ). In addition the decrease of dynamic variability of alpha anteriorization was found to be associated with an increase in the amplitude of P1/N1 components of auditory evoked potentials.
Ulrich
G
G
Psychiatrische Klinik, Freie Universität, Berlin, Germany.
Herrmann
W M
WM
Hegerl
U
U
Müller-Oerlinghausen
B
B
D000328:Adult; D000513:Alpha Rhythm / Q000187:drug effects; D001143:Arousal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D018020:Lithium Compounds; D008297:Male; D013431:Sulfates / Q000494:pharmacology*
D018020:Lithium Compounds; D013431:Sulfates; C054097:lithium sulfate; D008094:Lithium