Serum esterase activities and hyperlipidaemia in the streptozotocin-diabetic rat.
The levels of activity of four serum esterases were measured in control and streptozotocin-diabetic rats for a period of 6 months. Pseudocholinesterase activity was significantly elevated in the diabetic rats at all time points tested, reaching 250% of the control activity at 6 months. Levels of paraoxonase activity progressively decreased with time in the diabetic rats, being 36% lower than in controls at 6 months. No significant differences in either serum arylesterase or carboxylesterase activity between control and diabetic rats were observed.
Patel
B N
BN
Department of Biochemistry and Molecular Biology, University of Manchester Medical School, U.K.
Mackness
M I
MI
Harty
D W
DW
Arrol
S
S
Boot-Handford
R P
RP
Durrington
P N
PN
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000150:complications; D004950:Esterases / Q000097:blood*; D006949:Hyperlipidemias / Q000209:etiology*; D008297:Male; D051381:Rats; D013311:Streptozocin; D014280:Triglycerides / Q000378:metabolism
D001786:Blood Glucose; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol; D004950:Esterases