title: Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43.
abstract: Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components--the U1 RNA true multigene family and a group of class I U1 pseudogenes--are located on human chromosome 1.
authors: Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213.
authors: K
authors: K
authors: Neiswanger
authors: D R
authors: DR
authors: Stanford
authors: R S
authors: RS
authors: Sparkes
authors: D
authors: D
authors: Nishimura
authors: T
authors: T
authors: Mohandas
authors: I
authors: I
authors: Klisak
authors: C
authors: C
authors: Heinzmann
authors: E D
authors: ED
authors: Wieben
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D005810:Multigene Family; D011544:Pseudogenes; D015183:Restriction Mapping; D012261:Ribonucleoproteins / Q000235:genetics*; D017411:Ribonucleoproteins, Small Nuclear; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear