[The combined action of N-methyl-N'-nitro-N-nitrosoguanidine and UV light on Bacillus subtilis].
The mutagenic interaction between ultraviolet irradiation and the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine was studied in repair-competent and excision-deficient strains of Bacillus subtilis. Pre-exposure to low doses of MNNG with following treatment by low and intermediate doses of UV light increase the resistance of Bac. subtilis to UV radiation (antagonistic effect). Probably pre-exposition with MNNG leads to induction of enzymes reparation, UV damages being controlled with adaptive response genes.
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D001412:Bacillus subtilis / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D013997:Time Factors; D014466:Ultraviolet Rays
D008769:Methylnitronitrosoguanidine
Kombinirovannoe deĭstvie N-metil-N'-nitro-N-nitrozoguanidina i UF-sveta na Bacillus subtilis.