Cardiopulmonary effects of epidurally administered xylazine in the horse.
This study was designed to determine whether the epidural administration of an alpha2 agonist, xylazine, would produce measurable changes in arterial blood pressure, electrocardiographic (ECG) activity and arterial blood gas values in horses. Six horses were given each of four treatments: epidural xylazine, intravenous xylazine, epidural lidocaine and epidural saline. A carotid artery catheter was used to measure arterial blood pressure and to collect samples for blood gas analysis before treatment and at intervals post treatment. Heart rate, arterial pressures, ECG activity and respiratory rate were recorded at the same intervals. No significant changes were recorded between time intervals or between individual treatments. It was concluded that this method of xylazine administration to horses produced potent caudal analgesia without measurable cardiopulmonary effects.
Leblanc
P H
PH
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824.
Eberhart
S W
SW
D015360:Analgesia, Epidural / Q000662:veterinary*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D008012:Lidocaine; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects*; D014991:Xylazine / Q000008:administration & dosage
D002245:Carbon Dioxide; D014991:Xylazine; D008012:Lidocaine; D010100:Oxygen