Nesidioblastosis associated with chronic experimental pancreatitis produced by a scorpion toxin, tityustoxin, in rats.
Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was injected intravenously (50 micrograms/kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesion characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals.
Novaes
G
G
Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil.
Chetto-de-Queiroz
A
A
De-Carvalho-Cardoso
C
C
Burlacchini-de-Carvalho
M H
MH
Ribeiro-Filho
L A
LA
Oliveira-Gonçalves
A
A
D000818:Animals; D002908:Chronic Disease; D007275:Injections, Intravenous; D008297:Male; D010182:Pancreatic Diseases / Q000473:pathology*; D010195:Pancreatitis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012604:Scorpion Venoms / Q000633:toxicity*
D012604:Scorpion Venoms; C003609:tityustoxin