title: Differences between arterial and mixed venous levels of plasma hydroperoxides following major thoracic and abdominal operations.
abstract: Fatty acid hydroperoxides in the plasma of 18 patients who were undergoing normal postoperative periods following major thoracic or abdominal operations were measured by using a sensitive assay based upon the activation of the cyclooxygenase activity of prostaglandin H synthase. Following major thoracic operations of nine patients, the mean difference between the arterial (0.49 +/- 0.13 microM, mean +/- S.E.M.) and mixed venous (-0.09 +/- 0.12 microM) level of hydroperoxide was 0.58 +/- 0.13 microM (p less than 0.01). In marked contrast to this result, major abdominal operations of nine patients led to a mean difference between the arterial (-0.19 +/- 0.16 microM) and mixed venous (0.46 +/- 0.08 microM) hydroperoxide levels of -0.65 +/- 0.17 microM (p less than 0.01). Both pulmonary and intraabdominal tissues appear capable of generating significant amounts of fatty acid hydroperoxide in response to standard surgical procedures. The A-MV differences suggest that the blood-borne hydroperoxides were rapidly cleared from the circulation by tissue capillary beds.
authors: Department of Surgery, University of Illinois College of Medicine, Chicago 60612.
authors: R R
authors: RR
authors: Keen
authors: L A
authors: LA
authors: Stella
authors: D P
authors: DP
authors: Flanigan
authors: W E
authors: WE
authors: Lands
mesh_terms: D000005:Abdomen / Q000601:surgery; D004789:Enzyme Activation; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood*; D011184:Postoperative Period; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood / Q000378:metabolism; D011651:Pulmonary Artery / Q000378:metabolism; D013903:Thoracic Surgery
chemical_list: D005609:Free Radicals; D008054:Lipid Peroxides; D006861:Hydrogen Peroxide; D011451:Prostaglandin-Endoperoxide Synthases