Cutaneous phototoxic occurrences in patients receiving Photofrin.
Incidence of cutaneous phototoxic reactions induced by intravenous injection of Photofrin polyporphyrin was assessed in a series of 180 patients (266 injections) undergoing photodynamic therapy (PDT) at Roswell Park Cancer Institute during the period 1986-1989. In addition to the usual verbal questions regarding phototoxic reactions solicited at follow-up, forty-two patients in this group also responded to a written questionnaire designed to solicit answers to specific questions. Photofrin doses ranged from 0.5 to 2.0 mg/kg. Overall, 20-40% of patients reported some type of phototoxic response.
Dougherty
T J
TJ
Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263.
Cooper
M T
MT
Mang
T S
TS
D000970:Antineoplastic Agents / Q000009:adverse effects*; D005500:Follow-Up Studies; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D010349:Patient Compliance; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011795:Surveys and Questionnaires
D000970:Antineoplastic Agents; D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative