[IgA nephropathy (Berger's disease). Our experience in 78 cases].
We studied 78 patients with a diagnosis of IgA nephropathy. Renal biopsy was indicated in 69 patients by the presence of macroscopic hematuria (52%), microhematuria or proteinuria (22%), nephrotic syndrome (10%), severe hypertension with microhematuria or renal failure (14%) or nephritic syndrome (1%). Nine were healthy subjects being studied as live kidney donors. An association with IgG and/or IgM was present in 92% of patients. Serum IgA was elevated in 36% of patients. Hypertension was present in 30% and decreased renal function in 29%. Patients with serum creatinine above 1.5 mg/dl tended to be older (33.8 vs 28.7 years) and to have hypertension (52% vs 19%). Among 25 patients followed for more than 12 months renal function remained stable in 44%, deteriorated in 20% and 36% developed renal failure. The latter was associated to older age, hypertension, absence of macroscopic hematuria and nephrotic syndrome. The 9 live donors had no clinical manifestations of renal disease. Thus, IgA nephropathy is a highly variable clinical entity, both in its manifestations and its prognosis. An asymptomatic course is demonstrated in some subjects.
Jara
A
A
Departamento de Nefrourología, Hospital Clínico, P Universidad Católica de Chile, Santiago de Chile.
Vial
S
S
Rosenberg
H
H
Cisternas
H
H
Becker
J
J
Vaccarezza
A
A
Flores
J C
JC
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002677:Chile / Q000453:epidemiology; D005260:Female; D005922:Glomerulonephritis, IGA / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
Nefropatía por IgA (enfermedad de Berger). Experiencia en 78 casos.