Murine lymph nodes in response to the local administration of dextran sulphate.
In mice a single injection of 4 mg of Dextran sulphate within a few days produces an enlargement of area draining lymph nodes and activates basophils/mast cells. This activation is manifested by many-fold increase of mast cell number per lymph node, degranulation of mast cells and appearance of young, immature mast cells capable to synthetize new granules. In contrast to the lymph nodes, the Dextran-injected connective tissue mast cells remained unchanged. This suggest that Dextran sulphate directly activates lymph node mast cells, probably by activation of T-cell suppressor or macrophages.
Włodarski
K
K
Department of Histology and Embryology, Institute of Biostructure, Medical Academy, Warszawa.
Jankowska
E
E
Marciniak
M
M
Gryglas
P
P
Grzesik
A
A
D000818:Animals; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D016264:Dextran Sulfate