[A solitary central maxillary incisor and holoprosencephaly in siblings].
In families in which holoprosencephaly seems to be inherited by a rare dominant autosomal mutation, some individuals exhibit a single central maxillary incisor (SCMI). This anomaly was considered a minimal manifestation of the gene for holoprosencephaly. We report on a family, in which one child suffered from median cleft lip and palate and alobar holoprosencephaly, whereas the other child only had a SCMI. In the father and his sister lateral upper incisors were absent. Therefore the question is raised as to whether this anomaly may be related to the same condition.
Süss
J
J
Institut für Humangenetik der Universität Erlangen-Nurnberg.
Pfeiffer
R A
RA
Zschiesche
S
S
König
R
R
D000848:Anodontia; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D016142:Holoprosencephaly / Q000473:pathology*; D006801:Humans; D007180:Incisor / Q000002:abnormalities*; D007223:Infant
Ein solitärer mittlerer oberer Schneidezahn und Holoprosencephalie bei Geschwistern.