[Effect of 3-hydroxy-lup-20(29)en-23-28-dioic acid on rat experimental gastric ulcers].
3-hydroxy-lup-20(29) en-23-28-dioic acid (HLEDA) at doses of 50-100 mg/kg was found to be an effective anti-ulcer agent in three rat experimental gastric ulcer models: the indomethacin-induced, pyloric ligation-induced, and absolute alcohol-induced ulcers. Its anti-ulcer activities were similar to those of carbenoxolone. HLEDA was shown to increase the hexosamine levels in gastric juice collected from pylorus ligated stomachs. No influence on gastric secretion and peptic activity was observed. Carbenoxolone was found to significantly inhibit the elimination of Na+ and K+ in rat urine. HLEDA had no effect on the elimination of Na+ and K+.
Zhang
S R
SR
Institute of Materia Medica, Beijing.
D000818:Animals; D000897:Anti-Ulcer Agents; D002229:Carbenoxolone / Q000627:therapeutic use; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D008297:Male; D051379:Mice; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D014315:Triterpenes / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D006595:Hexosamines; D014315:Triterpenes; C068052:3-hydroxylup-20(29)en-23,28-dioic acid; D012964:Sodium; D002229:Carbenoxolone; D011188:Potassium