Beta-alanine, like glycine, microinjected into the rat nucleus tractus solitarii increases blood pressure.
Microinjections of beta-alanine and glycine into the nucleus tractus solitarii (NTS) of the rat, led to an increase in blood pressure and heart rate. The responses to glycine but not to beta-alanine could be blocked by strychnine. Both amino acids reduced the responses to aortic nerve stimulation. High K+ stimulation caused a calcium-dependent release of beta-alanine from tissues in the area of the NTS. These results suggest that beta-alanine and glycine may modulate the cardiovascular control within the NTS.
Kubo
T
T
Department of Pharmacology, Yokohama City University, School of Medicine, Japan.
Kihara
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D004558:Electric Stimulation; D005998:Glycine / Q000008:administration & dosage; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000008:administration & dosage; D015091:beta-Alanine / Q000008:administration & dosage*
D015091:beta-Alanine; D013331:Strychnine; D011188:Potassium; D002118:Calcium; D005998:Glycine