Effect of toremifene on the activity of NK-cells in NZB/NZW mice.
The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells.
Wärri
A
A
Farmos Group Ltd, Research Center, Turku, Finland.
Kangas
L
L
D000818:Animals; D002860:Chromium Radioisotopes; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D017312:Toremifene
D002860:Chromium Radioisotopes; D004965:Estrogen Antagonists; D007370:Interferon Type I; D013629:Tamoxifen; D004958:Estradiol; D017312:Toremifene