Studies on nonspecific protection induced with OMP of Shigella flexneri and other genera of Enterobacteriaceae.
Outer membrane proteins (OMP) isolated from Shigella flexneri, Escherichia coli, Proteus vulgaris and Salmonella typhimurium were tested for their protective activity. Each OMP preparate given to mice intraperitoneally in a single injection (5 micrograms/per mouse) protected the animals not only in homologous but also in varying intensity in heterologous systems. Evidence was obtained that this nonspecific protection is cell mediated.
Czarny
A
A
Laboratory of Medical Microbiology, Polish Academy of Sciences, Wrocław.
Witkowska
D
D
Mulczyk
M
M
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D003429:Cross Reactions; D004755:Enterobacteriaceae / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000517:prevention & control; D004926:Escherichia coli / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D011514:Proteus vulgaris / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D012763:Shigella flexneri / Q000276:immunology*
D001425:Bacterial Outer Membrane Proteins