Effect of prepubertal consumption of zearalenone on puberty and subsequent reproduction of gilts.
Forty-eight prepubertal gilts (178.7 +/- 4.1 d; 94.2 +/- 4.1 kg), 16 in each of three trials, were assigned randomly to receive 0 (C) or 10 ppm zearalenone (Z) daily in 2.5 kg of a 14% protein finishing ration for 2 wk. Blood samples were collected at 20-min intervals for 4 h 1 wk after the start of the experiment and 1 wk after Z was withdrawn. Two weeks after Z was withdrawn, gilts were exposed to mature boars 15 min per day for 3 wk. Gilts in estrus were mated to two different boars 12 h apart. Twice each week, blood was sampled and analyzed for progesterone to establish age of puberty. Age at puberty differed (P = .008) among replicates but was similar (P = .13) between Z and C gilts within each replicate. Mean serum concentrations of LH were suppressed (P = .025) during consumption of Z (.25 vs .42 ng/ml) but were similar (P = .16) to concentrations in C gilts 1 wk after Z was withdrawn (.35 vs .45 ng/ml). Frequency and amplitude of LH secretory spikes did not differ (P greater than .50) between Z and C gilts during either sampling period. Mean serum concentrations of FSH were similar (P = .25) between Z and C gilts. Number of corpora lutea and live fetuses were similar (P = .29 and P = .94, respectively) between Z and C gilts. Fetal weights were greater (P = .025) and crown to rump length tended to be greater (P = .10) in fetuses from Z gilts.(ABSTRACT TRUNCATED AT 250 WORDS)
Green
M L
ML
Purdue University, West Lafayette, IN 47907.
Diekman
M A
MA
Malayer
J R
JR
Scheidt
A B
AB
Long
G G
GG
D000821:Animal Feed; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005506:Food Contamination; D008098:Litter Size / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011897:Random Allocation; D012098:Reproduction / Q000187:drug effects*; D012118:Resorcinols / Q000009:adverse effects*; D012741:Sexual Maturation / Q000187:drug effects*; D013552:Swine / Q000254:growth & development / Q000502:physiology*; D015430:Weight Gain; D015025:Zearalenone / Q000009:adverse effects*
D012118:Resorcinols; D011374:Progesterone; D015025:Zearalenone; D007986:Luteinizing Hormone