[Unintentional intrathecal administration of a tenfold dose of methotrexate].
Unintentional administration of methotrexate intrathecally in a dose 10 times higher than normal was not followed by any adverse effects in the treated child. The possibility is discussed of using higher than presently used doses of this drug in the prevention and treatment of leukaemic infiltrations in the central nervous system.
Kaczmarek
M
M
Klinika Chorób Dzieci Instytutu Pediatrii Akademii Medycznej im. Karola Marcinkowskiego, Poznaniu.
Radwańska
U
U
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008508:Medication Errors; D008727:Methotrexate / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012074:Remission Induction
D008727:Methotrexate
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