title: [Optimization of methods and organization of the chemotherapeutic prevention of tuberculosis in children in family foci of infection].
abstract: The influence of controlled chemotherapeutic prevention measures taken by visiting nurses by means of an intermittent method and that of a non-controlled activities (through the distribution of antituberculous drugs among parents) on the decrease of tuberculosis morbidity, primary infection and tuberculin sensitization in 431 children, aged between 6 months and 14 years and representing family foci of the infection, were studied. As compared with a non-controlled approach, the controlled chemotherapeutic prevention by means of an intermittent method brings the tuberculosis morbidity in children from the infection foci and the primary infection rate down to 7.5 and 3.1 times, respectively, and significantly decreases an average size of the infiltrate formed by the Mantoux test reaction with 2TU of PPD-L. The use of the non-controlled chemotherapeutic prevention seems to be not advisable, since it fails to cause any meaningful changes in the drop of the morbidity, primary infection or tuberculin sensitization rates.
authors: A
authors: A
authors: Murriev
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000008:administration & dosage*; D012423:Rural Health; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*; D014423:Turkmenistan
chemical_list: D007538:Isoniazid
vernacular_title: Optimizatsiia metodiki i organizatsii provedeniia khimioprofilaktiki tuberkuleza u deteĭ v semeĭnykh ochagakh infektsii.