title: The effect of enprostil on duodeno-jejunal motility in man.
abstract: Motor changes could be involved in the pathogenesis of diarrhoea that complicates the treatment of ulcer disease by prostaglandins. Our aim was to assess the effect of enprostil, a synthetic analogue of PGE2, on duodeno-jejunal motility. During this randomized double-blind crossover study, two manometric recordings, each lasting 20 h (12.00-08.00 hours), were carried out during dosing with 35 micrograms enprostil b.d. or placebo (eight volunteers: part 1), or during dosing with 35 or 70 micrograms enprostil b.d. (nine volunteers: part 2). Subjects were only allowed a standard dinner at 18.00 hours. During fasting, in part 1, the number of phase 3 activity patterns (PIIIs) was higher with enprostil than with placebo (P less than 0.01), without any difference in their characteristics; the overall duration of phase 1 activity was longer with enprostil than with placebo (P less than 0.01). In part 2, during fasting the number and characteristics of the PIIIs were not different, but there was a dose-related increase in PI, and decrease in PII activity. Fed motor patterns did not differ between the two doses of enprostil.
authors: Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle, Hôpital Charles Nicolle, Rouen, France.
authors: P
authors: P
authors: Ducrotte
authors: B
authors: B
authors: Parent
authors: C
authors: C
authors: Masliah
authors: M
authors: M
authors: Joubert
authors: R
authors: R
authors: Colin
authors: P
authors: P
authors: Denis
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D016620:Enprostil; D005502:Food; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D011459:Prostaglandins E, Synthetic; D016620:Enprostil