[Modification of the teratogenesis of actinomycin D and cyclophosphamide by a Mycoplasma pulmonis infection in rats].
In the present investigation experiments have been made on the modification of the teratogenesis by a Mycoplasma pulmonis infection in rats. Substances with known teratogenic effects (Actinomycin D, Cyclophosphamide) were used. Groups of artificially infected pregnant rats were compared with pregnant rats from the SPF unit. The present study has shown that in the group of artificially infected animals no significant increase of the teratogenic effects by Actinomycin was found. In the Cyclophosphamide-treated groups more and more serious malformations have been observed in relation to dose and day of treatment.
Juhr
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NC
Institut für Tierschutz, Verhaltenslehre und Versuchstierkunde Freien Universität Berlin.
Ratsch
H
H
D000014:Abnormalities, Drug-Induced; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D003609:Dactinomycin / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced* / Q000150:complications; D009175:Mycoplasma Infections / Q000150:complications*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms
D003609:Dactinomycin; D003520:Cyclophosphamide
Modifikation der Teratogenese von Actinomycin-D und Cyclophosphamid durch eine Mycoplasma pulmonis-Infektion bei der Ratte.