[The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats].
The effect of vegetative nervous system activation or depression (subdiaphragmatic vagotomy, atropine, proserine and acetylcholine treatments) on the hepatic microsomal enzymes activities has been studied on Wistar male rats. It is found, that hepatic denervation and atropine treatment decreased cytochrome P450 content and aniline hydroxylase activity. Proserine and acetylcholine induced an opposite effect. It is considered that these different changes in the microsomal enzyme activities with variations in the vegetative nervous system state have proved the nervous control of these processes.
Ashirmetov
A Kh
AKh
Krakovskiĭ
M E
ME
D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000294:innervation*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology* / Q000601:surgery
D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D009251:NADPH-Ferrihemoprotein Reductase
Znachenie parasimpaticheskogo otdela nervnoĭ sistemy dlia reguliatsii aktivnosti mikrosomal'noĭ monooksigenazy v pecheni krys.