Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.
Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as effective as brain grafting in delivering various chemical agents to the brain. This method is much safer and simpler than brain grafting, since it bypasses many of the complicated problems associated with brain grafting. Application of this method to an animal experimental model for brain grafting and possibly in the treatment of parkinsonism should be considered along with brain grafting.
Yoshida
M
M
Department of Neurosurgery, Kurume University School of Medicine, Japan.
Torigoe
R
R
Ohtsuru
K
K
Kuramoto
S
S
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001971:Bromocriptine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D004343:Drug Implants; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D004343:Drug Implants; D006892:Hydroxydopamines; D001971:Bromocriptine; D013973:Thyrotropin-Releasing Hormone; D016627:Oxidopamine; D001058:Apomorphine