Intravenous erythromycin for postpyloric intubation.
Of 100 consecutive patients referred for antroduodenal manometry, we successfully intubated 89 with endoscopic and/or fluoroscopic guidance. In 8 of 8 patients who had failed with our usual techniques, we infused erythromycin 3 mg/kg i.v. over 1 h, and the tube moved through the pylorus and into the duodenum. Erythromycin, which stimulates propagation of 3 high amplitude antral contractions/min, appears to be a safe, noninvasive means to facilitate the postpyloric passage of tubes.
Di Lorenzo
C
C
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance 90502.
Lachman
R
R
Hyman
P E
PE
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004386:Duodenum / Q000187:drug effects*; D004917:Erythromycin / Q000008:administration & dosage / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal / Q000379:methods*; D008365:Manometry / Q000379:methods*
D004917:Erythromycin