title: Antiendometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin.
abstract: No previous study has investigated prospectively the quantitative effect of treatment on antiendometrial antibody levels in endometriosis. We measured antiendometrial antibody levels by an enzyme-linked immunosorbent assay in 35 women with laparoscopically proved endometriosis who were treated for 6 months with danazol (N = 11) or nafarelin (N = 24) in a randomized double-blind study. Levels before treatment were significantly higher than in a control group (P less than .001). Levels were lowered by treatment, but to a significant extent only in the nafarelin group (P less than .001) (danazol group: P = .091). Our data suggest that in relation to antiendometrial antibodies, nafarelin has a suppressive effect which has previously been ascribed only to danazol.
authors: Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, United Kingdom.
authors: S H
authors: SH
authors: Kennedy
authors: P M
authors: PM
authors: Starkey
authors: I L
authors: IL
authors: Sargent
authors: B R
authors: BR
authors: Hicks
authors: D H
authors: DH
authors: Barlow
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D003613:Danazol / Q000627:therapeutic use*; D004311:Double-Blind Method; D004715:Endometriosis / Q000188:drug therapy / Q000276:immunology*; D004717:Endometrium / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D015337:Multicenter Studies as Topic; D017274:Nafarelin; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000276:immunology*; D011245:Pregnadienes / Q000627:therapeutic use*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
chemical_list: D001323:Autoantibodies; D011245:Pregnadienes; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D003613:Danazol