Homeostasis changes induced by the action of ethanol on the materno-fetal complex in rats. VII. Effects on some alkaline and alkaline-earth metals of blood serum.
The effect of chronic biparental preconceptional alcoholization followed by alcohol consumption during the preimplantation period on the maternal and fetal homeostasis of some alkaline and alkaline-earth metals was studied in albino rats. Female and male rats consumed 20% ethanol (v/v) for 50-60 days before mating (group E). Further on pregnant females were alcoholized until day 5 of pregnancy. Control females and males consumed tap water (group C). Animals were sacrificed on day 20 of pregnancy. Blood samples were obtained from fetuses (the blood of each litter being pooled) and from pregnant females. Biochemical determinations were made by atomic emission spectroscopy for Na and K and by atomic absorption spectroscopy for Ca and Mg. Early and late mortality of conceptuses were checked. Non significant changes were observed within group E in the maternal serum as to Na (increase) and K(decrease), while Ca and Mg showed a significant decrease. Similar changes were found in the pooled fetal serum, the decrease of K and Mg being less marked. No structural anomalies were detected. With respect to tanatogenesis, both early resorptions and late fetal death were increased.
Gârban
Z
Z
Academy of Medical Sciences, Dept. Biochemistry, Timişoara, Romania.
Daranyi
G
G
Gergen
I
I
Prunkl
A
A
Stefan
C
C
Gogoaşa
I
I
D000818:Animals; D002118:Calcium / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006706:Homeostasis; D008274:Magnesium / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D008670:Metals / Q000097:blood*; D011188:Potassium / Q000097:blood; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood
D008670:Metals; D000431:Ethanol; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium