Inhibition of liver metastases in nude mice by the combined action of 5-fluorouracil and interferon.
Liver metastasis in nude mice was studied using LoVo, a cell line developed from a patient with adenocarcinoma of the colon. LoVo cells injected into the spleen of 4-week-old nude mice showed 100% tumorigenicity in the spleen and metastases to the liver. This system was used to study ways in which to improve the efficacy of 5-FU, which was used in combination with alpha-2a interferon. Our results show that interferon can potentiate the effect of 5-FU in inhibiting liver metastases. Either drug given alone did not show comparable inhibition.
McBee
P
P
Mercy Hospital, Pittsburgh, PA 15219.
Petraiuolo
W
W
Katoh
A
A
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D051379:Mice; D008819:Mice, Nude; D011994:Recombinant Proteins; D013160:Splenic Neoplasms / Q000556:secondary
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005472:Fluorouracil