title: Immunohistological phenotyping of the stomach infiltrating lymphocytes in chronic gastritis.
abstract: Subsets of lymphocytes infiltrating the gastric mucosa were phenotyped by their surface antigens in biopsies of 30 patients with chronic gastritis (12 with superficial, 9 with atrophic gastritis and 9 with gastric atrophy) and 10 controls. Using direct and indirect immunofluorescent staining, monoclonal antibodies OKT3, OKT4, OKT8, OKB7, antiLeu11b and anti-IL-2 receptor were employed to detect T cell subsets, B cells, NK cells and activated cells. Most of the infiltrating lymphocytes were T cells expressing the CD4 phenotype. B cell proportions were found to increase in relation to the severity of the gastric lesion. IL-2 receptor positive cells were significantly increased in superficial gastritis. These findings indicate an involvement of T cells in the pathogenesis of chronic gastritis. Furthermore, the predominance of CD4 positive cells together with the increase of B cells parallel to the severity of the gastric lesion possibly support the concept of a T-B cooperation leading to tissue damage.
authors: 2nd Medical Department, Aristotelian University, Thessaloniki, Greece.
authors: M
authors: M
authors: Raptopoulou-Gigi
authors: M
authors: M
authors: Polyzonis
authors: H
authors: H
authors: Orphanou-Koumerkeridou
authors: J
authors: J
authors: Agorastos
authors: J
authors: J
authors: Vacolas
authors: P
authors: P
authors: Gigis
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D002452:Cell Count; D005260:Female; D005756:Gastritis / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000473:pathology; D006801:Humans; D008211:Lymphocyte Cooperation; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000473:pathology*
chemical_list: D000943:Antigens, Differentiation