title: Counteraction of nifedipine-induced hyperglycaemia by metformin.
abstract: Nifedipine-induced hyperglycaemia in rats was counteracted by concurrent administration of metformin (500 mg/kg p.o.). However, glibenclamide (5 mg/kg p.o.) did not change the hyperglycaemic effect of nifedipine. It is suggested that nifedipine-induced hyperglycaemia was not related to pancreatic effect and might be attributed to extra pancreatic mechanism by preventing the action of insulin in the tissues. Therefore, counteraction of nifedipine-induced hyperglycaemia by metformin, may play a role in diabetic patients treated with nifedipine.
authors: College of Pharmacy, Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.
authors: A R
authors: AR
authors: Abu-Jayyab
authors: E S
authors: ES
authors: el-Denshary
authors: H A
authors: HA
authors: el-Sawaf
authors: A M
authors: AM
authors: al-Bekairi
mesh_terms: D000818:Animals; D005905:Glyburide / Q000627:therapeutic use; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009543:Nifedipine / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: D008687:Metformin; D009543:Nifedipine; D005905:Glyburide