Oncogene proteins as molecular epidemiologic markers of cancer risk in hazardous waste workers.
Although DNA adducts are a relatively early marker in the carcinogenic process, it would be desirable to have a molecular epidemiologic marker of a later step--late enough in the process that it is of clear significance to the development of malignancy, but not too late to preclude effective intervention to abort the process. Such a molecular epidemiologic marker that may have particular relevance for cancer screening in occupational cohorts with potential carcinogen exposure, such as hazardous waste workers, is based on oncogene expression.
Brandt-Rauf
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Division of Environmental Sciences, Columbia-Presbyterian Medical Center, New York, New York 10032.
D014408:Biomarkers, Tumor / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D006256:Hazardous Waste; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009369:Neoplasms / Q000139:chemically induced / Q000175:diagnosis*; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis*; D015513:Oncogene Proteins / Q000032:analysis*
D014408:Biomarkers, Tumor; D006256:Hazardous Waste; D015513:Oncogene Proteins