The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.
The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.
Poblador
M S
MS
Department of Morphological Sciences, Faculty of Medicine, University of Córdoba, Spain.
Rojas
C
C
Raya
A
A
Casares
J A
JA
Aparicio
J
J
Lancho Alonso
J L
JL
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006056:Golgi Apparatus / Q000648:ultrastructure; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D003520:Cyclophosphamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone