Pulsatile gonadotropin releasing hormone substitution following extirpation of suprasellar craniopharyngioma.
A craniopharyngioma growing suprasellarly attacks the medio-basal region of the hypothalamus, interrupting the production of gonadotropin-releasing hormone. In the case of a 15-year-old girl who underwent partial extirpation of craniopharyngioma, favorable endocrine effects were obtained by pulsatile gonadotropin-releasing hormone treatment. Gonadotropin-releasing hormone administered in a dose of 20 micrograms every 90 min resulted in the achievement of a menstrual cycle and ovulation. Together with surgical treatment, hormonal substitution plays an important role in the treatment of endocrine symptoms.
Koloszár
S
S
Department of Obstetrics and Gynecology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Bártfai
G
G
D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D003397:Craniopharyngioma / Q000150:complications / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D007986:Luteinizing Hormone / Q000097:blood; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery*
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone