title: Diethylcarbamazine decreases ethanol-injury to the gastric mucosa of the rat.
abstract: Exposure of the rat stomach to ethanol stimulates the generation of leukotrienes. Leukotrienes are potent mediators of tissue inflammation and injury. In this work we show that pretreatment with diethylcarbamazine, a lipoxygenase enzyme inhibitor, significantly decreases ethanol injury to the rat gastric mucosa. At a dose of 250 mg/kg the compound significantly reduced the ETOH-stimulated mucosal LTC4 generation by 40% and PGE2 generation by 79%. We conclude that diethylcarbamazine is an inhibitor of the cyclooxygenase and lipoxygenase enzymes in the gastric mucosa. That inhibition of leukotriene synthesis decreases the extent of ethanol-stimulated suggests that leukotrienes play a key role in mediating ethanol-injury to that tissue.
authors: Good Samaritan Medical Groups, San Jose, CA 94124.
authors: M A
authors: MA
authors: Balaa
authors: C
authors: C
authors: Subramony
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors; D004049:Diethylcarbamazine / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology; D015289:Leukotrienes / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D000431:Ethanol; D015232:Dinoprostone; D004049:Diethylcarbamazine