[Experimental study of the course of the immune response at the urinary level following repeated oral vaccination].
The Progression of the specific immunoreactions in the urines of rabbits vaccinated by oral route from 1 to 10 times with 20-40 billion of some antigens (E. coli, Proteus vulgaris, Staph aureus, Str. faecalis), administered daily or by-weekly, has been evaluated by agglutination and ELISA. The immunoenzymatic ELISA technique has revealed increases of specific immunoglobulins also one day after the first oral administration of the antigens and a final progression of IgA titres (after ten treatments) from 81% to 798%, according to the various antigens and the different posology. The highest values have been obtained using the posology of 40 billion and the bi-weekly sequence.
Negretti
F
F
Cattedra di Microbiologia e Igiene, Università degli Studi di Milano.
Casetta
P
P
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000652:urine*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013293:Enterococcus faecalis / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D007115:Immunization Schedule; D007070:Immunoglobulin A / Q000652:urine*; D011514:Proteus vulgaris / Q000276:immunology; D011817:Rabbits; D013209:Staphylococcal Vaccines / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D013209:Staphylococcal Vaccines
Studio sperimentale sulla evoluzione delle risposte immunitarie a livello urinario in seguito a vaccinazioni ripetute per via orale.