Comparison of Tc-99m MAG3 and Tc-99m DTPA in renal transplant patients with impaired renal function.
Tc-99m mercaptoacetyltriglycine (MAG3) is a new Tc-99m renal agent that compares favorably to I-131 Hippuran in animal models, normal volunteers, and patients. Based on the fact that Tc-99m MAG3 has a much more rapid clearance than Tc-99m DTPA and a smaller volume of distribution, it was postulated that the image quality of Tc-99m MAG3 studies should be superior to scans obtained using Tc-99m DTPA, particularly in patients with impaired renal function. To test this hypothesis, Tc-99m DTPA and MAG3 images were obtained in three transplant patients during periods of stable but impaired renal function. In one study, the Tc-99m DTPA study was potentially misleading, whereas the Tc-99m MAG3 examination assessed the clinical situation correctly. In all three cases, the Tc-99m MAG3 images were superior.
Taylor
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A
Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322.
Ziffer
J A
JA
Eshima
D
D
D000328:Adult; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate; D014511:Uremia / Q000000981:diagnostic imaging
D009842:Oligopeptides; D015609:Organotechnetium Compounds; D017263:Technetium Tc 99m Mertiatide; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate