The effect of ondansetron on gastric emptying in the conscious rat.
The 5-HT3 receptor antagonist ondansetron (GR38032F) enhanced the action of a protein-rich solution in delaying gastric emptying in the conscious gastric fistula rat, but had no effect on the emptying of isotonic or hypertonic saline, acid or FOY-305 which delays emptying by release of cholecystokinin (CCK). The specific CCK-A antagonist (L-364,718) increased gastric emptying of protein-rich meals. L364,718 also increased emptying in the presence of ondansetron. They indicate that protein-rich meals release both CCK and 5-hydroxytryptamine which act in different ways to control gastric motility.
Forster
E R
ER
Physiological Laboratory, University of Liverpool, U.K.
Dockray
G J
GJ
D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D005747:Gastric Fistula / Q000503:physiopathology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D017294:Ondansetron; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists; D013997:Time Factors
D007093:Imidazoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017294:Ondansetron