[Correlation of the results of neurotensin therapy and plasma levels in paranoid schizophrenia].
The subjects were 21 paranoid schizophrenic patients (10 women, 11 men). The average duration of illness was 4.5 years. The severity of psychopathological symptoms was evaluated using BPRS-LA before and on 7 and 21 day of trifluoperazine therapy (60 mg per os). Simultaneously plasma neurotensin (NT) level was determined by radioimmunologic method. In 11 patients a considerable improvement was obtained, in 7 cases there were only a minimal changes, in remaining 2 a worsening of symptoms was observed. The plasma neurotensin changes were of minimal value and did not correspond to clinical symptoms and diagnosis.
Zych
F
F
II Katedry i Zakładu Patofizjologii Sl. A.M. w Katowicach.
Zgirski
L
L
Krowicki
Z
Z
Urban
S
S
Sadowska-Krowicka
H
H
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009496:Neurotensin / Q000097:blood*; D012016:Reference Values; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors; D014268:Trifluoperazine / Q000008:administration & dosage / Q000627:therapeutic use*
D014268:Trifluoperazine; D009496:Neurotensin
Próba korelacji wyników leczenia schizofrenii paranoidalnej z poziomem neurotensyny w osoczu krwi.