title: [The determination of immunological parameters in splenectomized patients].
abstract: We studied 15 patients submitted to splenectomy. Humoral immunity was studied with protein electrophoresis and quantification of immunoglobulins; cellular immunity was studied by total and subpopulation lymphocyte counts and evaluation of phagocytosis. Increased levels of IgG, IgM and IgA, a decrease in circulating T-lymphocytes and an increased phagocytosis was seen after operation. These findings correlated to the presence of viral and parasitic infections postoperatively. Preoperative antipneumococcal vaccination prevented infections by this agent. Thus, appropriate preventive measures must be taken to deal with altered immunological responses after splenectomy.
authors: Departamento de Preclínicos, Facultad de Medicina, Universidad de Chile, Santiago.
authors: A
authors: A
authors: Ardiles
authors: M C
authors: MC
authors: Acevedo
authors: M A
authors: MA
authors: Varas
authors: M A
authors: MA
authors: Parra
authors: J
authors: J
authors: Orellana
authors: C
authors: C
authors: Santa Cruz
authors: L
authors: L
authors: Pérez
authors: P
authors: P
authors: Lemp
authors: L
authors: L
authors: Vargas
authors: M
authors: M
authors: Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002677:Chile / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007107:Immune System / Q000276:immunology*; D015994:Incidence; D017053:Infection Control / Q000706:statistics & numerical data; D007239:Infections / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D013156:Splenectomy / Q000706:statistics & numerical data
vernacular_title: Determinación de parámetros inmunológicos en pacientes esplenectomizados.