[Removal of the ortho isomer of 4,4-bis(4-fluoro phenyl) butanoic acid by sulfonation].
4,4-Bis(4-fluorophenyl) butanoic acid is an important pharmaceutical intermediate. It is usually prepared by Friedel-Crafts reaction of 4-(4-fluorophenyl) butyrolactone with fluorobenzene. But the ratio of products is often affected by reaction conditions. By applying sulfonation, the undesired isomer can be successfully removed.
Fan
H A
HA
Middle South Pharmaceutical Factory, Shaoyang.
D002087:Butyrates / Q000138:chemical synthesis / Q000302:isolation & purification*; D007536:Isomerism
D002087:Butyrates; C067946:4,4-bis(4-fluorophenyl)butanoic acid