[The significance of a new radiopharmaceutic agent, 99mTc-mercaptoacetyltriglycine (MAG 3), in the diagnosis of diseases of the kidneys and urinary tract in children].
Using the method of dynamic scintigraphy of the kidneys by means of a new radiopharmaceutical preparation, 99mTc--mercaptoacetyltriglicide [MAG 3], the authors examined 35 children with various urological and nephrological diseases. In indicated cases the examination was supplemented by administration of a diuretic, further projections or indirect mictional cystography. The authors assessed normal parameters of functional curves and their normal extent in a group of 18 healthy kidneys. They did not find a significant difference, as compared with results obtained by means of 131I-OIH. The assessed values of global clearance attained 66% of the 131I-OIH clearance values. In 60% of the patients the visualization of the parenchyma and in 80% the visualization of the efferent urinary pathways was better than when 99mTc-DTPA was used. In all instances the scintigrams were better than when 131I-OIH was used. The new radiopharmaceutical preparation combines the advantages of technetium-labelled preparations and the favourable pharmacokinetic properties of hippuran. It is suitable for quantification of tubular secretion. It is superior to hitherto used substances as regard the quality of visualization and in particular the lower radiation load. Therefore it is particularly suited for paediatric practice.
Lepej
J
J
Klinika nukleárnej medicíny Lekárskej fakulty Univerzity Komenského, Martin.
Svitác
J
J
Kliment
J
J
Buchanec
J
J
Marosová
A
A
Altmann
P
P
Horák
V
V
Holan
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007465:Iodohippuric Acid; D007668:Kidney / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D008297:Male; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D017263:Technetium Tc 99m Mertiatide; D014551:Urinary Tract / Q000000981:diagnostic imaging; D014570:Urologic Diseases / Q000000981:diagnostic imaging*
D009842:Oligopeptides; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide
Význam nového rádiofarmaka 99mTc-merkaptoacetyltriglycínu (MAG 3) v diagnostike ochorení obliciek a mocových ciest u detí.