title: Regrowth and connectivity of injured central nervous system axons in adult rodents.
abstract: The capacity of injured nerve cells to regrow and form terminal connections in the CNS of adult mammals was investigated in axotomized retinal ganglion cells (RGCs) of rodents whose optic nerves were substituted by an autologous segment of peripheral nerve. While many RGCs died after axotomy approximately 20% of the surviving RGCs regenerated axons several cm in length. Some of the regenerated RGC axons entered the superior colliculus where they arborized and formed well differentiated synapses that transynaptically excited or inhibited tectal neurons.
authors: Centre for Research in Neuroscience, McGill University, Montreal General Hospital Research Centre, Canada.
authors: A J
authors: AJ
authors: Aguayo
authors: G M
authors: GM
authors: Bray
authors: D A
authors: DA
authors: Carter
authors: M P
authors: MP
authors: Villegas-Perez
authors: M
authors: M
authors: Vidal-Sanz
authors: M
authors: M
authors: Rasminsky
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002470:Cell Survival; D006224:Cricetinae; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000502:physiology*; D010543:Peroneal Nerve / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000502:physiology*; D014182:Transplantation, Autologous