The P-loop--a common motif in ATP- and GTP-binding proteins.
Many ATP- and GTP-binding proteins have a phosphate-binding loop (P-loop), the primary structure of which typically consists of a glycine-rich sequence followed by a conserved lysine and a serine or threonine. The three-dimensional structures of several ATP- and GTP-binding proteins containing P-loops have now been solved. In this review current knowledge of P-loops is discussed with the additional aim of illustrating the fascinating relationship between protein sequence, structure and function.
Saraste
M
M
European Molecular Biology Laboratory, Heidelberg, FRG.
Sibbald
P R
PR
Wittinghofer
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
D011506:Proteins; D000255:Adenosine Triphosphate; D019204:GTP-Binding Proteins