[Enoxacin in the treatment of male genital infections in patients with antisperm autoimmune pathology].
Anti-sperm antibodies are frequently present in patients bearing infections of the genital tract and a cause-effect relationship is suspected in these two pathological conditions. In an open, uncontrolled study, the Authors tested the therapeutical effect on both autoimmune anti-sperm and infectious genital tract diseases. Thirty patients, age 30.3 +/- 3.6 years (mean +/- D.S.; range 25-42), were admitted to the study. In all patients the clinical diagnosis was confirmed by a positive sperm culture for enoxacin sensitive germs. Eleven out of 30 patients (36.7%) were also found to be positive by both immunofluorescence and immunoenzymatic tests for Chlamydia Trachomatis at the beginning of the study. At day 0 (first menstrual cycle day of the patients' partner) enoxacin treatment (300 mg twice daily) was started with the patients and their partners for a period of 30 and 12 days respectively. Sperm culture and both the above mentioned tests for Chlamydia Trachomatis were subsequently repeated on day 5 of therapy (first control) and at 1, 3, 6 and 12 months (2nd, 3rd, 4th, and 5th controls respectively) after the end of treatment. Statistical analysis of the results was performed by both Dunnett and Chi-square tests as appropriate. Isolated germs from pre-treatment sperm culture were classified as Enterococcus (17/30 cases: 56.7%) E. Coli (8/30: 26.6%), Klebsiella (2/30: 6.6%) and St Albus, Proteus and Enterococcus-Klebsiella coinfections (1/30 cases: 3.3% each).(ABSTRACT TRUNCATED AT 250 WORDS)
Lombardo
F
F
Istituto di 5a Clinica Medica, Università di Roma "La Sapienza" - Policlinico Umberto I.
Gandini
L
L
Alfano
P
P
Anticoli Borza
L
L
Lenzi
A
A
Dondero
F
F
D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D015365:Enoxacin / Q000627:therapeutic use*; D005832:Genital Diseases, Male / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000276:immunology*
D015365:Enoxacin
L'enoxacina nel trattamento delle infezioni del tratto genitale maschile in pazienti con associata patologia autoimmune antispermatozoo.