SCH 23390-induced hypophagia is blocked by the selective CCK-A receptor antagonist devazepide, but not by the CCK-B/gastrin receptor antagonist L-365,260.
The selective dopamine D-1 receptor antagonist SCH 23390 (30 micrograms/kg, SC) significantly reduced palatable food consumption by nondeprived rats in a 30-min test period. Prior administration of the selective CCK-A receptor antagonist devazepide (MK 329; L-364,718) blocked the hypophagic effect of SCH 23390. In contrast, prior administration of the selective CCK-B/gastrin receptor antagonist L-365,260 had no effect. Devazepide did not antagonize a matched hypophagic effect produced by the dopamine D-2 receptor antagonist raclopride (0.1 mg/kg, SC). These data direct attention to possible dopamine-cholecystokinin interactions in relation to the control of ingestional responses, and, more specifically, indicate possible functional relationships between D-1 and CCK-A receptor mechanisms.
Cooper
S J
SJ
School of Psychology, University of Birmingham, U.K.
Barber
D J
DJ
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D002766:Cholecystokinin / Q000502:physiology; D020109:Devazepide; D004298:Dopamine / Q000502:physiology; D018492:Dopamine Antagonists; D001068:Feeding and Eating Disorders / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D010671:Phenylurea Compounds; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1
D001552:Benzazepines; D001570:Benzodiazepinones; D018492:Dopamine Antagonists; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; C058121:L 365260; D002766:Cholecystokinin; D020109:Devazepide; D004298:Dopamine