Albendazole: a more effective antigiardial agent in vitro than metronidazole or tinidazole.
The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis.
Meloni
B P
BP
Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, Western Australia.
Thompson
R C
RC
Reynoldson
J A
JA
Seville
P
P
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005872:Giardia / Q000187:drug effects*; D008795:Metronidazole / Q000494:pharmacology; D014011:Tinidazole / Q000494:pharmacology
D014011:Tinidazole; D008795:Metronidazole; D015766:Albendazole