Dose-dependent emergence of preneoplastic foci in rat livers after exposure to 2-nitropropane.
Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. Thirteen weeks after starting the experiments the logarithms of the numbers of preneoplastic liver foci deficient in adenosine-5'-triphosphatase were found to be linearly related to the exposure concentrations of 2-nitropropane. Male rats exhibited an approximately four times lower foci incidence than females.
Denk
B
B
GSF-Institut für Toxikologie, Neuherberg, Federal Republic of Germany.
Filser
J G
JG
Deml
E
E
Kessler
W
W
Shen
J
J
Oesterle
D
D
D000251:Adenosine Triphosphatases / Q000172:deficiency; D000280:Administration, Inhalation; D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D009595:Nitroparaffins / Q000008:administration & dosage / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology; D011407:Propane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000473:Alkanes; D009595:Nitroparaffins; C025647:clophen A50; D011078:Polychlorinated Biphenyls; D000251:Adenosine Triphosphatases; C016617:2-nitropropane; D011407:Propane