Synaptophysin expression in the striatum in Huntington's disease.
This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.
Goto
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Bluestone Laboratory, Division of Neuropathology, Montefiore Medical Center, Bronx, NY 10467-2490.
Hirano
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D000911:Antibodies, Monoclonal; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D016708:Synaptophysin
D000911:Antibodies, Monoclonal; D008565:Membrane Proteins; D016708:Synaptophysin