title: Hairy cell leukemia preferentially expresses the IgG3-subclass.
abstract: Surface IgG expression of 29 cases of hairy cell leukemia (HCL) was assessed using IgG-subclass-specific monoclonal and F(ab)'2 polyclonal antibodies. A marked preference for the IgG3 subclass was found, as 16 of 19 IgG-positive HCL's expressed IgG3. In 10 cases, IgG3 was concurrently expressed with other heavy chains. No preferential IgG3 expression was observed in 11 IgG-positive non-Hodgkin's lymphomas. The marked predominance of IgG3 in HCL suggests a deviation in heavy chain class switching that may be related to the characteristically very low expression of LFA-1 and ICAM-1 molecules on hairy cells, and hence a defect in T-cell hairy cell interaction.
authors: Department of Hematomorphology and Immunotyping, University Hospital, Leiden, The Netherlands.
authors: H C
authors: HC
authors: Kluin-Nelemans
authors: M M
authors: MM
authors: Krouwels
authors: J H
authors: JH
authors: Jansen
authors: K
authors: K
authors: Dijkstra
authors: M J
authors: MJ
authors: van Tol
authors: G J
authors: GJ
authors: den Ottolander
authors: E J
authors: EJ
authors: Dreef
authors: P M
authors: PM
authors: Kluin
mesh_terms: D000943:Antigens, Differentiation / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification*; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D011961:Receptors, Fc / Q000378:metabolism; D017452:Receptors, IgG
chemical_list: D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG