[Antipyretic action of aniline derivatives in rats during different parts of the day].
The results of experiments and clinical observations have demonstrated that pharmacologic action of many drugs depend on the time of administration. The aim of the experiments was to evaluate the antipyretic action of phenacetin, p-phenetidine and acetaminophen in rats administered at different periods of day. The effects of continuous illumination, adrenalectomy and induction or inhibition of microsomal enzymes on antipyretic action of phenacetin were evaluated. The experiments were carried out on 177 Wistar male rats 3.0-4.5 months of age. Fever was induced by intraperitoneal injection of pyrogen (10 micrograms/kg). The antipyretics were given intragastrically (1.12 mmol/kg). It was found that antipyretic action of aniline derivatives decreased in this order: p-phenetidine, phenacetin and acetaminophen. In rats maintained under standard LD conditions antipyretic action of phenacetin and p-phenetidine was more pronounced in a morning than in an evening. Continuous illumination, adrenalectomy, phenobarbital or SKF 525-A administered abolished that difference in rats. Concluding, antipyretic action of aniline derivatives in rats varied in circadian manner only in case when these compounds have an ethoxy-group metabolized by microsomal monooxygenases. The observed phenomenon in this experiment is controlled by the hypothalamic-pituitary-adrenal system.
Rachtan
R
R
Zakładu Toksykologii Przemysłowej, Akademii Medycznej im. M. Kopernika, Krakowie.
Starek
A
A
D000082:Acetaminophen / Q000008:administration & dosage*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005334:Fever / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010615:Phenacetin / Q000008:administration & dosage*; D010628:Phenetidine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D010628:Phenetidine; D000082:Acetaminophen; D010615:Phenacetin
Przeciwgoraczkowe działanie pochodnych aniliny u szczurów w róznych porach doby.