[Epidemics of lung tumors in a Biella tannery].
A cluster of 7 lung cancer deaths among workers of a small tannery in Biella is reported. The major process in the plant, until the end of World War II, was chromium and vegetable tanning. A historical cohort study was carried out on a total of 353 male workers. The expected number of death was estimated on the basis of local mortality rates. An SMR for lung cancer of 449 (95% C.L. 180-925) was found for the entire cohort. Excluding workers non specifically employed in tanning operations, the SMR for lung cancer increased to 1087 (95% C.L. 352-2533). In order to control for potential confounders a nested case-control study was planned. The next-of-kin of 8 cases deceased for lung cancer and 32 controls matched by age were interviewed on smoking habits and previous jobs. Logistic regression analysis showed an O.R. of 6.94 (95% C.L. 1.18-40.73), adjusted for smoking habits and occupational history, for subjects involved in tanning operations. A registry of incident cases of cancer was established in order to avoid biased findings based on cluster cases.
Bonassi
S
S
Servizio di Epidemiologia, Istituto Nazionale per la Ricerca sul Cancro, Genova.
Merlo
F
F
Puntoni
R
R
Ferraris
F
F
Bottura
G
G
D000328:Adult; D016022:Case-Control Studies; D016000:Cluster Analysis; D004196:Disease Outbreaks; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D009790:Occupations; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking; D013633:Tanning
Epidemia di tumori polmonari in una conceria del biellese (VC).