title: Structural and histoenzymatic aspects of metronidazol on rat gonads.
abstract: Metronidazol, an efficient drug for Trichomonas vaginalis, Lamblia intestinalis and some anaerobic germs, administered in a daily dose of 500 mg/kg body weight for 60 and 40 days in males and females, respectively, produces severe structural alterations (atrophy and cytolysis, more apparent in the testicle) and elicits, a functional impairment as well (modifications in the activity of some enzymes: alkaline and acide-phosphatase, Mg(2+)-ATPase, CyOx, SDH, LDH). These morphological and histoenzymological changes in the steroidogenic formations suggest that Metronidazol severily affects the gametogenesis and hormonogenesis in rat.
authors: Biological Research Centre, Cluj-Napoca, Romania.
authors: V D
authors: VD
authors: Sandu
authors: C
authors: C
authors: Puica-Dat
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D010053:Ovary / Q000033:anatomy & histology* / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000033:anatomy & histology* / Q000187:drug effects / Q000201:enzymology
chemical_list: D008795:Metronidazole