Pulmonary endocrine cells in plexogenic pulmonary arteriopathy.
A study of the numbers of pulmonary endocrine cells per cm2 of section of lung obtained at combined heart-lung transplantation in 25 cases of plexogenic pulmonary arteriopathy demonstrated that the peptide which may become unduly prominent in pulmonary arterial disease is bombesin. The type of vascular disease in which bombesin becomes prominent is plexogenic pulmonary arteriopathy, be this primary or secondary to congenital heart disease. The increased prominence of bombesin appears to be related to the stage reached in the arteriopathy. Increased numbers of pulmonary endocrine cells are found in association with classic cellular plexiform lesions with narrow vascular channels. Their numbers are within normal limits when the plexiform lesions are mature with wide vascular channels and narrow intervening septa. The pulmonary endocrine cells are most prominent in the pre-plexiform stage when smooth muscle cells in the inner half of the media of the pulmonary artery show increased electron density, and migrate through gaps in the inner elastic lamina to reach the intima. Here they are transformed into myofibroblasts and proliferate. The migration of muscle cells may be related in some way to long-acting trophic factors released from the pulmonary endocrine cells into the surrounding tissues from which they reach the blood and hence the pulmonary arteries.
Heath
D
D
Department of Pathology, University of Liverpool, London.
Madden
B
B
Yacoub
M
M
D000293:Adolescent; D000328:Adult; D001839:Bombesin / Q000096:biosynthesis; D002116:Calcitonin / Q000378:metabolism; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009490:Neurosecretory Systems / Q000473:pathology*; D011651:Pulmonary Artery / Q000378:metabolism / Q000473:pathology; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology*
D002116:Calcitonin; D001839:Bombesin