Acute phase proteins in neonatal rabbits: diminished C-reactive protein response.
Acute phase protein response accompanies tissue injury, inflammation, or infection. During the acute phase, serum levels of C-reactive protein (CRP) can increase as much as 1,000-fold. We found that in response to an intramuscular injection of turpentine, neonatal rabbit CRP-specific RNA and serum CRP rose minimally. In contrast, adult serum levels of CRP increased 20-fold and mRNA for CRP in adults increased commensurately. However, during neonatal acute phase reactions, changes in the synthesis of the third component of complement (C3) and albumin were induced, implying a dysynchronous development of the response of various acute phase proteins.
Baker
R D
RD
Division of Pediatric Gastroenterology and Nutrition, University of Massachusetts Medical Center, Worcester 01655.
Long
S
S
D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D003176:Complement C3 / Q000235:genetics / Q000378:metabolism*; D003720:Densitometry; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits; D012709:Serum Albumin / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D014425:Turpentine
D003176:Complement C3; D012333:RNA, Messenger; D012709:Serum Albumin; D002097:C-Reactive Protein; D014425:Turpentine