[The pharmacokinetics of hematoporphyrin, its derivative and fluorescein during the development of carcinosarcoma].
The pharmacokinetics of fluorescein, hematoporphyrin and a derivative of hematoporphyrin was studied microspectrofluorometrically on rats with transplanted carcinosarcoma. It was shown that in the rats in contrast to intact animals the tissue concentration of fluorescein exhibits a general tendency towards an increase, that of hematoporphyrin towards a decrease and that of hematoporphyrin derivative towards an increase in all parenchymatous organs and a decrease in the skin and mucosae of the hollow organs. At the equally short period of the maximal accumulation of luminophores, the tumour tissue differs from the normal one by a pronounced delay of excretion only of hematoporphyrin derivative.
Barabash
R D
RD
Skobelkin
O K
OK
Petukhov
M I
MI
Normanskiĭ
V E
VE
Riazhskiĭ
G G
GG
Mironova
M I
MI
Andreeva
K P
KP
Kolobanov
A S
AS
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D005260:Female; D005452:Fluoresceins / Q000493:pharmacokinetics*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D005452:Fluoresceins; D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative
Farmakokinetika gematoporfirina, ego proizvodnogo i fliuorestseina pri razvitii kartsinosarkomy.