title: Design and conduct of clinical trials in osteoarthritis.
abstract: Clinical features of osteoarthritis (OA) require that general recommendations for the design and conduct of clinical trials be modified in order to apply these concepts to clinical trials in OA. A format has been devised for design of clinical trials in OA. In order to assess the applicability of this format, it has been compared to a published clinical trial: chondroprotective agents versus standard treatment of OA of the knee. The published study appeared reliably designed and conducted in a manner that provided an answer to most of the questions posed. The study appears to form a sound basis for additional studies.
authors: Division of Rheumatology, School of Medicine, University of Miami, Florida 33101.
authors: R D
authors: RD
authors: Altman
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006025:Glycosaminoglycans / Q000627:therapeutic use; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D014020:Tissue Extracts / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006025:Glycosaminoglycans; D014020:Tissue Extracts; C000562:Rumalon; C010034:Arteparon