Therapy of refractory, recurrent heart rejection with multiple courses of OKT3.
The treatment for recurrent cardiac allograft rejection refractory to conventional immunotherapy is retransplantation. When retransplantation is not possible, alternative approaches must be undertaken. This report reviews the successful management of persistently recurring rejection using five serial 14-day courses of OKT3 in a 35-year-old man after two heart transplantations.
Frist
W H
WH
Department of Cardiac and Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn.
Gerhardt
E B
EB
Merrill
W H
WH
Atkinson
J B
JB
Eastburn
T E
TE
Stewart
J R
JR
Hammon
J W
JW
Bender
H W
HW
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D016853:Muromonab-CD3; D012008:Recurrence
D000911:Antibodies, Monoclonal; D016853:Muromonab-CD3