Effects of standard cigarette and nicotine-less cigarette smoke inhalings on nicorandil plasma levels in rats.
The influence of cigarette smoke on nicorandil plasma levels at a dose of 10 mg/kg administered orally was investigated in rats. The animals were exposed to standard and nicotine-less cigarette smoke for 8 min using a 'smoking machine'. In nonsmoking control rats, nicorandil plasma levels increased rapidly and reached the maximum (approx. 7.6 micrograms/ml) after 1 h and then decreased gradually. On the other hand, nicorandil plasma levels in the rats inhaling standard cigarette and nicotine-less cigarette smoke reached the maximum (approx. 4.7 and 4.9 micrograms/ml, respectively) after 1-2 h. These results suggest that nicorandil plasma levels after oral administration are influenced not only by standard cigarette smoke but also by nicotine-less cigarette smoke.
Gomita
Y
Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Eto
K
K
Furuno
K
K
Araki
Y
Y
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D020108:Nicorandil; D009538:Nicotine / Q000494:pharmacology*; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D013997:Time Factors; D014026:Nicotiana / Q000032:analysis
D009536:Niacinamide; D020108:Nicorandil; D009538:Nicotine