T cell differentiation in birds.
Avian T cell development has been traced using monoclonal antibodies specific for chicken T cell surface differentiation antigens. The basic antigen recognition molecules, differentiation pathways, and functional capabilities defined for T cells in mammals are highly conserved in birds. Novel features of T cell development are also revealed. These include the generation of a third T cell sublineage that expresses a different receptor isotype (TCR3) and a novel lineage of cytoplasmic CD3+ lymphoid cells (TCR0 cells). In contrast to the TCR0 cell lineage, the sublines of T cells bearing the three TCR isotypes are all generated exclusively within the thymus.
Chen
C L
CL
Department of Pediatrics, University of Alabama, Birmingham.
Bucy
R P
RP
Cooper
M D
MD
D000818:Animals; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis; D001717:Birds / Q000276:immunology*; D008213:Lymphocyte Activation / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell