Abnormal Ca2(+)-ATPase activity in erythrocytes of non-insulin-dependent diabetic rats.
Non-insulin-dependent diabetic (NIDD) rats have an increased Ca2(+)-ATPase activity in their kidney basolateral membranes. We find that a similar increased activity occurs in erythrocytes of the NIDD animals. This alteration in membrane ATPase activity appears to be specific for the Ca2(+)-ATPase as (Na(+) + K+) and Mg2(+)-ATPase and Na, K and Mg concentrations in the erythrocyte were not affected by the diabetic condition in these animals. Thus, abnormalities in membrane Ca2(+)-ATPase activity in the NIDD rats are not restricted to one tissue and appear to be a generalized pathology in the NIDD animals.
Levy
J
J
Division of Endocrinology, Metabolism and Hypertension, Wayne State University School of Medicine, Detroit, Michigan.
Sowers
J R
JR
Zemel
M B
MB
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D000252:Calcium-Transporting ATPases / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000252:Calcium-Transporting ATPases