The adoptive transfer of T-cell dependent immunity to Plasmodium chabaudi chabaudi in CBA/Ca mice is achieved only after superinfection of immune spleen cell donors.
The transfer of spleen cells from CBA/Ca mice recovered from a P. c. chabaudi AS primary infection into irradiated syngeneic recipients conferred very poor protection. Neither elimination of Ly2 cells from immune spleen cells nor reinfection of the donors some days before transfer improved protection significantly. Significant protection was transferred with spleen cells from donors which had been infected 7 times prior to cell transfer. Transferred protection was reduced or eliminated by pretreatment of cells with anti-Thy-1 or anti-L3T4 monoclonal antibodies but not with anti-Ly2.
Favila-Castillo
L
L
Division of Parasitology, National Institute for Medical Research, London, U.K.
Jarra
W
W
Brown
K N
KN
D000818:Animals; D000911:Antibodies, Monoclonal; D000950:Antigens, Ly / Q000276:immunology; D007109:Immunity; D007116:Immunization, Passive; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010961:Plasmodium / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014916:Whole-Body Irradiation
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly