A family study of lithium-responsive psychosis.
Psychiatric life histories of 487 first-degree family members of 24 lithium-responsive (mood-incongruent) psychotics, 54 lithium-nonresponsive (mood-incongruent) psychotics, and 18 lithium-responsive patients with bipolar (manic-depressive) disorder were contrasted. While the morbid risk of schizophrenic-spectrum was 11.1% in relatives of lithium-nonresponsive probands, the morbid risk for such disorders was only 2.4% in relatives of lithium-responsive (mood-incongruent) psychotics (P less than 0.05). This lithium-responsive illness appears to be familially, and perhaps genetically, distinct from the bulk of the schizophrenias.
Sautter
F J
FJ
Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, LA 70118.
McDermott
B E
BE
Garver
D L
DL
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy / Q000235:genetics*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology
D016651:Lithium Carbonate; D008094:Lithium