[Physiopathology and therapy of female idiopathic hirsutism. State of the art].
This review aims at focusing current pathogenetic theories on female idiopathic hirsutism. Glandular hormonal synthesis, plasma transport of androgenic hormones, and cutaneous metabolism and utilization of testosterone are discussed in detail. The Authors then propose some therapeutic strategies: antiandrogen drugs are discussed with special reference to cyproterone acetate and spironolactone.
Molinatti
G M
GM
Istituto di Medicina Interna dell'Università degli Studi di Torino.
Biffignandi
P
P
D000311:Adrenal Glands / Q000378:metabolism; D000726:Androgen Antagonists / Q000627:therapeutic use; D000728:Androgens / Q000378:metabolism; D003534:Cyproterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017373:Cyproterone Acetate; D005260:Female; D005485:Flutamide / Q000627:therapeutic use; D006628:Hirsutism / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D010053:Ovary / Q000378:metabolism; D012737:Sex Factors; D012867:Skin / Q000378:metabolism; D013148:Spironolactone / Q000627:therapeutic use
D000726:Androgen Antagonists; D000728:Androgens; D013148:Spironolactone; D017373:Cyproterone Acetate; D005485:Flutamide; D003534:Cyproterone; D007654:Ketoconazole
Fisiopatologia e terapia dell'irsutismo idiopatico femminile. Lo stato dell'arte.