Assessment of antimicrobial penetration into the pancreatic juice in dogs.
The pancreatic ductal penetration of piperacillin, cefuzonam, fosfomycin and netilmicin, injected intravenously, was studied in four dogs with chronic pancreatic fistula. Serum and pancreatic juice were collected simultaneously, frozen, and later assayed for antibiotic concentration. Each antibiotic achieved its therapeutic serum level. The pancreatic ductal levels of piperacillin and cefuzonam were therapeutic, in contrast, the fosfomycin and netilmicin levels were subtherapeutic. These results are considered to be of interest in prevention and treatment of pancreatic infections.
Miyamoto
M
M
Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
Sudo
T
T
Kuyama
T
T
Kawamura
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D015296:Ceftizoxime / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004285:Dogs; D005260:Female; D005578:Fosfomycin / Q000493:pharmacokinetics; D008297:Male; D009428:Netilmicin / Q000493:pharmacokinetics; D010189:Pancreatic Juice / Q000378:metabolism*; D010878:Piperacillin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D009428:Netilmicin; C049934:cefuzonam; D015296:Ceftizoxime; D010878:Piperacillin