Cholinergic blockade in prefrontal cortex and hippocampus disrupts short-term memory in rats.
The muscarinic antagonist scopolamine was injected into the prefrontal cortex and hippocampus of rats that were well trained in an operant delayed non-matching to position task. Cholinergic antagonism in the hippocampus induced dose- and delay-dependent deficits, characteristic of impaired short-term retention. By contrast, cholinergic antagonism in the prefrontal cortex induced dose-dependent but delay-independent deficits, suggesting disturbance of some non-mnemonic regulatory process in the neocortex.
Dunnett
S B
SB
Department of Experimental Psychology, University of Cambridge, UK.
Wareham
A T
AT
Torres
E M
EM
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005508:Food Deprivation / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology
D010276:Parasympatholytics; D012601:Scopolamine