A review of the antimicrobial activity of the fluoroquinolones.
The evolution of the fluoroquinolones is described, and structure-activity relationships outlined. The in-vitro antimicrobial activities of ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin against a wide range of organisms are critically reviewed. In-vitro factors influencing fluoroquinolone activity are discussed. Reports of the acquisition of resistance to the fluoroquinolones are evaluated. Finally, possible future directions for this group of antibiotics are discussed.
Maple
P
P
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, U.K.
Brumfitt
W
W
Hamilton-Miller
J M
JM
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents