title: A case of malignant histiocytosis successfully treated with combination interferon and etoposide therapy.
abstract: A 66-year-old woman with malignant histiocytosis was treated with a combination of recombinant gamma interferon (GI-3) and etoposide. Following partial response to intravenous gamma interferon (9 x 10(6) units (U)/day) alone, the patient received an eight-months course of subcutaneous gamma interferon (0.5 x 10(6) U/day) and intravenous etoposide (100 mg/week). After two years, the patient remains in complete remission. The present case report discusses the successful use of combination gamma interferon and etoposide for the treatment of malignant histiocytosis.
authors: First Department of Internal Medicine, Hirosaki University School of Medicine.
authors: H
authors: H
authors: Takemori
authors: Y
authors: Y
authors: Sakata
authors: H
authors: H
authors: Suzuki
authors: T
authors: T
authors: Yamaya
authors: N
authors: N
authors: Furugori
authors: S
authors: S
authors: Morimoto
authors: Y
authors: Y
authors: Yoshida
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage* / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D005047:Etoposide; D007371:Interferon-gamma