[Anti-inflammatory effect of aconitines].
Aconitines are the total alkaloids isolated from the main root of Aconitum carmichaeli. They have marked suppressive effect on the swelling of rat's hind paw induced by injections of fresh egg protein, carrageenin, histamine and 5-HT, on the mouse's ear oedema induced by bimethylphenyl, on the exudate and proliferation of granulation tissue of granuloma pouch induced by croton oil, on the leukocyte migration and on the contents of PGE in the exudate of the swelling hind paw induced by injecting carrageenin. Aconitines have been found useful in inhibiting significantly such immune inflammations as reversible passive Arthus reaction, rat's delayed skin hypersensitivity and adjuvant arthritis. They have also a noticeable analgesic effect.
Shi
H
H
Jilin Institute of Chinese Materia Madica, Academy of Traditional Chinese Medicine, Changchu.
Zhou
C
C
Li
Y
Y
Wang
G
G
Sun
Y
Y
D000157:Aconitine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D001183:Arthus Reaction / Q000188:drug therapy; D005260:Female; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000157:Aconitine