Testicular histology after treatment with LH-RH analogue for carcinoma of the prostate.
Orchiectomy was performed in 16 patients because of progression of prostatic cancer despite adequate medical castration with goserelin (Zoladex, ICI) over a mean period of 17.6 months. Severe tubular atrophy was seen in the testes. The Leydig cells also showed signs of atrophy, a fact that may indicate a direct effect of goserelin on these cells. In 1 patient, however, orchiectomy was postponed for 3 months after cessation of medical castration. The serum testosterone had resumed almost normal values and testicular histology revealed intact spermatogenesis and apparently normal Leydig cells.
Johansen
T E
TE
Department of Urology, Akershus Central Hospital, Nordbyhagen, Norway.
Ogreid
P
P
Kjellevold
K
K
Blom
P
P
D000368:Aged; D002064:Buserelin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017273:Goserelin; D006801:Humans; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013091:Spermatogenesis; D013737:Testis / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D017273:Goserelin; D013739:Testosterone; D002064:Buserelin