[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. II. The effect of the pharmaceutical product Boicil tablets on early embryogenesis, organogenesis and the fetus in 3 successive generations of rats and mice].
The effect of Boicil tablets on early embryogenesis (the first 3 gestational days), organogenesis (the 10th, 11th and 12th gestational days) and fetus (the 18th and 19th gestational days) by its intraamniotic administration was followed up in three successive generations of mice and rats. Two doses were used (2 mg/kg body weight and 20 mg/kg body weight), estimated in relation with the maximum therapeutic daily dose in man, being administered in a single dose, per os. No inborn malformations or somatic abnormalities were recorded both in mothers and in their descendents for three successive generations. It is concluded that Boicil tablets is not teratogenic.
Ionescu
D G
DG
Institutul de Medicină şi Farmacie Iaşi, Laboratorul central de testare a medicamentului, Disciplina de histologie şi Disciplina de anatomie.
Dobrescu
G
G
Adomnicăi
M
M
Mungiu
O C
OC
Costea
I
I
Teslaru
E
E
Filip
C
C
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006027:Glycosides / Q000633:toxicity*; D051379:Mice; D010936:Plant Extracts; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012503:Saponins / Q000633:toxicity*; D013256:Steroids; D013607:Tablets; D013997:Time Factors
D000893:Anti-Inflammatory Agents; C050166:Boicil; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D013607:Tablets
Evaluarea teratogenezei şi embriotoxicităţii la produsul farmaceutic Boicil comprimate. Nota II: Efectul produsului farmaceutic "Boicil comprimate" asupra embriogenezei precoce, organogenezei şi asupra fătului, la şobolani şi şoareci pe trei generaţii succesive.