Effect of parenteral administration of carnitine on liver regeneration in partially hepatectomized rats.
Male Wistar rats were subjected to 65-70% hepatectomy and either immediately or 18 h after surgery were given a 6-hour infusion containing 3 ml of either Ringer solution or aqua pro injectione alone or with L-carnitine in doses 8 mg (12.4 mumol), 40 mg (62 mumol) and 200 mg (310.2 mumol)/kg b.w. The rats were killed 6, 18, 24 and 30 h after surgery. The changes in the DNA specific activity and in the mitotic activity demonstrate that L-carnitine has a stimulating, dose-dependent effect on liver regeneration. This effect acts both during early post-hepatectomy, the prereplicative period and in the subsequent replicative period.
Bláha
V
V
Department of Physiology, Faculty of Medicine, Charles University.
Simek
J
J
Zivný
P
P
Sobotka
L
L
Zadák
Z
Z
D000818:Animals; D002331:Carnitine / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006498:Hepatectomy; D007275:Injections, Intravenous; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008940:Mitotic Index; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004247:DNA; D002331:Carnitine