Islet cell carcinoma of the pancreas. A study of 98 patients.
In 98 patients with histologically proved pancreatic islet cell carcinoma who were studied between 1950 and 1987, 55 had functioning tumors and 43 had nonfunctioning tumors. Both patient groups were compared in regard to age at presentation, metastases, and survival. Mean age at diagnosis was 51.1 years for the 55 men and 47 years for the 43 women. At diagnosis, 51 of the patients had regional disease and 47 had distant metastases. When matched for age, sex, and extent of disease, survival did not differ significantly in cases of functioning and nonfunctioning tumors. The patients' ages and the extent of disease at presentation were the most significant factors in prognosis and survival.
Venkatesh
S
S
Section of Endocrinology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Ordonez
N G
NG
Ajani
J
J
Schultz
P N
PN
Hickey
R C
RC
Johnston
D A
DA
Samaan
N A
NA
D007516:Adenoma, Islet Cell / Q000378:metabolism / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D000328:Adult; D005260:Female; D005755:Gastrins / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000628:therapy; D012189:Retrospective Studies; D016019:Survival Analysis
D005755:Gastrins; D006728:Hormones