[Early results of combined treatment (induction chemotherapy and radiotherapy) of patients with squamous cell carcinoma of the oropharynx].
The results of combined treatment (induction chemotherapy followed by irradiation) in 23 patients with locally advanced squamous cell carcinoma of the oropharynx were presented. Chemotherapy program included Cisplatin 100 mg/m2 i.v. in day 1 and 5-fluorouracil 750 mg/m2 i.v. on day 1-5. The chemotherapy was administered every 3 weeks for maximum 3 cycles. Complete response in 15 patients (65%), stabilization in 4 patients (17%) and progressive disease was found in 3 patients (14%). 20 patients were irradiated with radical intention. Complete response was found in 9 patients (45%) after radiotherapy. Treatment was relatively well-tolerated. Out of 17 patients with at least 6 months' follow-up (range 6-24) 6 patients are alive with no evidence of disease. We estimate the postirradiation reaction as slightly more severe than after radiotherapy alone. The reaction did not influence the prescribed way of fractionation.
Szutkowski
Z
Z
Zakładu Teleradioterapii II Centrum Onkologii, Instytutu im. Marii Skłodowskiej-Curie w Warszawie.
Krzakowski
M
M
Hliniak
A
A
Wasilewski
M
M
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000628:therapy*; D011882:Radiotherapy, High-Energy; D012074:Remission Induction; D013997:Time Factors
D002945:Cisplatin; D005472:Fluorouracil
Wczesne wyniki leczenia skojarzonego (chemioterapia indukcyjna i napromienianie) chorych na raka płaskonabłonkowego gardła środkowego.