title: Studies on clinical markers of diabetes mellitus. 6. Red blood cell sorbitol and diabetic complications.
abstract: The relationship between red blood cell sorbitol content and diabetic complications (cataract, retinopathy, neuropathy, and nephropathy) was examined in 23 non-insulin-dependent diabetic (NIDD) patients. Sorbitol content was abnormally high in 21 cases out of 23 NIDD patients. Sorbitol content in the non-neuropathy group and neuropathy group was 47.3 +/- 11.9 and 59.6 +/- 23.6 nmol/gHb, respectively. In the non-cataract group and cataract group, it was 49.0 +/- 17.6 and 66.0 +/- 23.5 nmol/gHb, respectively. The contents in the Scott I group and Scott II + III group were 54.9 +/- 20.7 and 58.7 +/- 24.0 nmol/gHb, respectively. Sorbitol content in the non-nephropathy group and nephropathy group was 52.8 +/- 19.8 and 61.1 +/- 21.9 nmol/gHb, respectively. The possibility that glyceraldehyde reductase (GAR) and sorbitol dehydrogenase (SDH) levels in red blood cells are also useful indicators of the presence of diabetic complications is strongly suggested.
authors: Department of Internal Medicine, Meikai University School of Dentistry, Saitama, Japan.
authors: M
authors: M
authors: Hatano
authors: K
authors: K
authors: Katsu
authors: H
authors: H
authors: Fuda
authors: H
authors: H
authors: Taguchi
authors: T
authors: T
authors: Aro
authors: S
authors: S
authors: Hiyoshi
authors: M
authors: M
authors: Sugiura
authors: S
authors: S
authors: Maruyama
mesh_terms: D015415:Biomarkers; D002386:Cataract / Q000097:blood / Q000201:enzymology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000201:enzymology; D003928:Diabetic Nephropathies / Q000097:blood / Q000201:enzymology; D003930:Diabetic Retinopathy / Q000097:blood / Q000201:enzymology; D004912:Erythrocytes / Q000737:chemistry / Q000201:enzymology; D005260:Female; D006801:Humans; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D008297:Male; D013012:Sorbitol / Q000097:blood*; D013401:Sugar Alcohol Dehydrogenases / Q000097:blood
chemical_list: D015415:Biomarkers; D013012:Sorbitol; D013401:Sugar Alcohol Dehydrogenases; C028041:glyceraldehyde reductase; D007064:L-Iditol 2-Dehydrogenase