title: The role of atrial natriuretic factor in dehydration and schedule-induced drinking behaviour.
abstract: Dehydration-induced drinking (DID) has been defined as a type of homeostatic behaviour controlled by factors related to water balance, whereas schedule-induced polydipsia (SIP) is considered to be a type of nonhomeostatic drinking subsequent to a general increase in motor excitability. In this study, we have attempted to assess the role of atrial natriuretic factor (ANF) in both models to elucidate the mechanisms controlling water intake. Intracerebroventricular injection of ANF (2-8 nmol) caused a dose related suppression of water intake in both DID and SIP, but intravenous injection with a higher dose of ANF (8 nmol) produced a significant suppression of water intake only in DID. Before drinking started, tissue ANF levels increased in atria in both models and decreased in hypothalamus in DID but not in SIP. After 1 hour of drinking, ANF levels decreased in atria in both models and increased in hypothalamus in SIP but not in DID. These results suggest that DID and SIP are different in their thirst regulation, and that the notion that peripheral ANF serves as a humoral factor sending signals to central in the fluid homeostatic control mechanism is questionable.
authors: Department of Pharmacology, National Defense Medical Center, Taipei Taiwan, Republic of China.
authors: C S
authors: CS
authors: Tung
authors: T H
authors: TH
authors: Chen
authors: C J
authors: CJ
authors: Tseng
authors: T H
authors: TH
authors: Yin
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000502:physiology*; D003681:Dehydration / Q000503:physiopathology*; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000378:metabolism; D006706:Homeostasis; D007031:Hypothalamus / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009320:Atrial Natriuretic Factor