title: Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans.
abstract: Prostaglandin E2 (PGE2), an immunosuppressive monokine that increases intracellular cyclic AMP (cAMP) levels, stimulated Candida albicans germ tube formation. Dibutyryl cAMP (dB-cAMP) and isoproterenol, other compounds that increase cAMP levels, also stimulated germination. Gamma interferon (IFN-gamma), a product of cellular immune system activation, inhibited Candida germ tube formation, even in the presence of PGE2, dB-cAMP, and isoproterenol. Thus, PGE2 and IFN-gamma as well as having opposing roles in the suppression or activation of cell-mediated immunity, are also antagonists for the yeast-to-hyphal transition of C. albicans.
authors: Department of Obstetrics and Gynecology, Cornell University Medical College, New York, New York 10021.
authors: A
authors: A
authors: Kalo-Klein
authors: S S
authors: SS
authors: Witkin
mesh_terms: D003994:Bucladesine / Q000494:pharmacology; D002176:Candida albicans / Q000166:cytology* / Q000187:drug effects; D015237:Dinoprost / Q000494:pharmacology; D015232:Dinoprostone / Q000494:pharmacology*; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology
chemical_list: D007370:Interferon Type I; D003994:Bucladesine; D007371:Interferon-gamma; D015237:Dinoprost; D015232:Dinoprostone; D007545:Isoproterenol