Iododerma and acute respiratory distress with leucocytoclastic vasculitis following the intravenous injection of contrast medium.
A 72-year-old woman with chronic renal failure requiring haemodialysis developed acute iododerma twice, after receiving iodide contrast dye for radiological procedures. Iododerma was localized to the face, scalp and elbows and was associated with papular purpura of the legs. Histopathology of the skin lesions showed acute necrotizing vasculitis. During the second skin eruption the patient developed acute respiratory distress, which was treated with corticosteroids. During the first eruption asymptomatic infiltrates were present on chest X-ray which disappeared 2 months later. At the present time iododerma seems more frequent in patients with renal failure. Iodides may also be responsible for pulmonary abnormalities, which are sometimes asymptomatic. All these features may be due to leucocytoclastic vasculitis following iodide ingestion.
Vaillant
L
L
Department of Dermatology, Hospital and University of Tours, France.
Pengloan
J
J
Blanchier
D
D
De Muret
A
A
Lorette
G
G
D000208:Acute Disease; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007454:Iodides / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000628:therapy; D006435:Renal Dialysis; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced*
D003287:Contrast Media; D007454:Iodides