Sympathetic denervation causes atrial natriuretic peptide-storing granules to appear in the ventricular myocardium of the rat.
Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant "atrial" granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (greater than 10 times higher than in control animals). We suggest that the sympathetic nervous system exerts a repressive effect upon synthesis of atrial natriuretic peptide-like material and upon the formation of atrial natriuretic peptide-storing granules in the ventricular myocardium.
Albino-Teixeira
A
A
Laboratorio de Farmacologia, Faculdade de Medicina, Porto, Portugal.
Polónia
J J
JJ
Azevedo
I
I
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000378:metabolism*; D006892:Hydroxydopamines; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D013563:Sympathectomy, Chemical
D006892:Hydroxydopamines; D009320:Atrial Natriuretic Factor; D016627:Oxidopamine; D009638:Norepinephrine