Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control.
We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.
Hall
G
G
University Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne, UK.
Lind
M J
MJ
Huang
M
M
Moore
A
A
Gane
A
A
Roberts
J T
JT
Cantwell
B M
BM
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000517:prevention & control; D004347:Drug Interactions; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008297:Male; D015080:Mesna / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D014859:Warfarin / Q000008:administration & dosage / Q000627:therapeutic use*
D014859:Warfarin; D015080:Mesna; D007069:Ifosfamide