title: Changes in disposition kinetics of sulphadimidine in response to acute regional liver damage in sheep.
abstract: Disposition kinetics of sulphadimidine in sheep, before and after regional liver damage by allyl alcohol, was investigated following a single IV injection (100 mg/kg). Allyl alcohol (12 mg/kg) provoked periportal liver lesion in 60 per cent of the animals. In normal sheep the mean elimination half-life of sulphadimidine was 7.47 +/- 1.09 hours. Liver damage significantly increased this value to 11.68 +/- 1.09 hours. Liver damage by allyl alcohol significantly changed the total body clearance (C1B), the overall elimination rate constant (beta) and the micro-constants k12 and kCl. The apparent volume of distribution (Vd) and the micro-constant k21 were not influenced by liver damage. The mean minimum steady-state concentration (Cp[min]) in normal sheep (38.43 micrograms/ml at 24 hours of interval) was found to be higher than previously reported. Liver intoxication significantly increased this value to 94.38 micrograms/ml. It is suggested that the regional liver damage has affected both the elimination and biotransformation of sulphadimidine.
authors: Laboratory of Physiology and Therapeutics, National Veterinary School of Alfort, Maisons, Alfort, France.
authors: T
authors: T
authors: Argaw
authors: H
authors: H
authors: Brugere
mesh_terms: D000818:Animals; D005260:Female; D006207:Half-Life; D008107:Liver Diseases / Q000378:metabolism / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism*; D013418:Sulfamethazine / Q000493:pharmacokinetics*
chemical_list: D013418:Sulfamethazine