[The reactogenicity and antigenic activity of a meningococcal group B vaccine made from a natural complex of the specific polysaccharide and outer membrane proteins].
Group B meningococcal vaccine consisting of the natural complex of specific polysaccharide and outer membrane protein (OMP) has been shown to be moderately reactogenic, safe with respect to the effect of undermining tolerance to human brain tissue antigens and to produce no allergization of humans. The vaccine under study possesses antigenic activity: (a) immunization with this vaccine ensures the fourfold rise of the level of antibodies to the group-specific polysaccharide of group B meningococcus in about 80% of persons with the initially low level of antibodies, this percentage being retained during the whole period of observation, i. e. 85 days; (b) the vaccine enhances the level of antibodies to meningococcal OMP, determined in the enzyme immunoassay and the passive hemagglutination test; (c) these data are indicative of the expediency of immunizing the risk groups of persons with the initially low level of antibodies.
Basnak'ian
I A
IA
Alliluev
A P
AP
Kuvakina
V I
VI
Levina
L A
LA
Krasnoproshina
L I
LI
Kotel'nikova
O V
OV
Karabak
V I
VI
Mordvitskiĭ
A M
AM
Borovkova
V M
VM
Aleksakhina
N N
NN
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000009:adverse effects* / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000009:adverse effects* / Q000276:immunology; D001428:Bacterial Vaccines / Q000009:adverse effects* / Q000276:immunology; D001921:Brain / Q000276:immunology; D004341:Drug Evaluation; D006388:Hemagglutinins / Q000097:blood; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009345:Neisseria meningitidis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000009:adverse effects* / Q000276:immunology; D013997:Time Factors
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D006388:Hemagglutinins; D011135:Polysaccharides, Bacterial; D007073:Immunoglobulin E
Reactogennost' i antigennaia aktivnost' vaktsiny meningokokkovoĭ gruppy B iz prirodnogo kompleksa spetsificheskogo polisakharida i belkov naruzhnoĭ membrany.