Association between tissue plasminogen activator and serum lipids in healthy volunteers.
The statistical association between tissue plasminogen activator (t-PA) activity, antigen, plasminogen activator inhibitor-1 (PAI-1) antigen and lipids levels in blood samples used for medical check ups in 111 volunteers attending hospital for health examinations was examined. The t-PA activity level of 111 volunteers was 0.08-0.56 ng/ml (5% trimmed range) (normal range: 0.08-0.70 ng/ml); t-PA antigen concentrations were 2.4-9.2 ng/ml (normal range: 1.0-7.0 ng/ml); PAI-1 antigen concentrations were 5.2-57.4 ng/ml (normal range: 5.2-45.0 ng/ml). The volunteers with the lowest t-PA activity in blood (group E) had higher concentrations of serum total cholesterol (P less than 0.001), triglycerides (P less than 0.001), or t-PA antigen (P less than 0.001) and lower concentrations of high-density lipoprotein cholesterol (P less than 0.001) than those having normal serum lipids and t-PA activity level (group A). These results show that t-PA activity, antigen and PAI-1 antigen in blood obtained from the healthy volunteers are influenced significantly by the concentrations of lipids in blood.
Yamada
R
R
Department of Laboratory Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Yamada
S
S
Ishii
A
A
Sasamata
M
M
Watanabe
S
S
D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000276:immunology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000276:immunology; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000276:immunology; D014280:Triglycerides / Q000097:blood
D000941:Antigens; D008076:Cholesterol, HDL; D008055:Lipids; D015849:Plasminogen Inactivators; D014280:Triglycerides; D002784:Cholesterol; D010959:Tissue Plasminogen Activator