title: Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene.
abstract: The human interferon (IFN) gamma receptor cDNA has been stably expressed in human/mouse somatic cell hybrids, which differ in their content of human chromosome 21. Despite high affinity IFN gamma binding-capacity of all receptor transfectants, biological responsiveness to IFN gamma, as determined by enhancement of mouse-MHC class I gene expression, required the presence of chromosome 21. These data suggest complementation of at least two functionally distinct components in order to create a biologically active IFN gamma receptor.
authors: Clinical Research Group, Max-Planck-Society, Klinische Arbeitsgruppe, Göttingen, F.R. Germany.
authors: T
authors: T
authors: Fischer
authors: A
authors: A
authors: Rehm
authors: M
authors: M
authors: Aguet
authors: K
authors: K
authors: Pfizenmaier
mesh_terms: D000818:Animals; D002891:Chromosomes, Human, Pair 21; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D005816:Genetic Complementation Test; D006183:H-2 Antigens / Q000502:physiology; D006801:Humans; D006822:Hybrid Cells; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D017471:Receptors, Interferon; D014162:Transfection
chemical_list: D006183:H-2 Antigens; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D007371:Interferon-gamma