title: The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.
abstract: The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.
authors: Department of Morphological Sciences, Faculty of Medicine, University of Córdoba, Spain.
authors: M S
authors: MS
authors: Poblador
authors: C
authors: C
authors: Rojas
authors: A
authors: A
authors: Raya
authors: J A
authors: JA
authors: Casares
authors: J
authors: J
authors: Aparicio
authors: J L
authors: JL
authors: Lancho Alonso
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006056:Golgi Apparatus / Q000648:ultrastructure; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone; D003520:Cyclophosphamide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone