Repeated treatment with imipramine, amitriptyline or electroconvulsive shock does not affect the 8-OH-DPAT-induced increase in food intake in free feeding rats.
We studied the effect of repeated treatment with imipramine, amitriptyline (10 mg/kg po, twice daily for 14 days) or electroconvulsive shock (ECS, once daily for 10 days) on the 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced increase in food intake in free feeding rats. The response to 8-OH-DPAT, measured 24 h after the last administration of the antidepressant drugs or ECS, was not modified. These results, together with literature data, indicate that the presynaptic 5-HT1A receptors involved in the 8-OH-DPAT-induced feeding are not affected by long-term antidepressant administration.
Przegaliński
E
E
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Baran
L
L
Siwanowicz
J
J
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D004597:Electroshock; D007099:Imipramine / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D000639:Amitriptyline; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007099:Imipramine