Influence of a new antiepileptic drug ORG 6370 on metrazol-induced seizures in rats during ontogenesis.
The anticonvulsant action of a new antiepileptic drug ORG 6370 (Organon International B.V.) was studied in 217 male albino rats aged 7, 12, 18, 25 and 90 days. Epileptic phenomena induced by a subcutaneous injection of a 100 mg/kg dose of metrazol (isolated myoclonic jerk, minimal metrazol seizures and major, generalized tonic-clonic metrazol seizures) were used as a model. ORG 6370 did not influence myoclonic jerks or minimal metrazol seizures in those age groups where they were regularly elicited. In 12-day-old rats pretreatment with ORG 6370 led to the appearance of minimal metrazol seizures, a phenomenon rarely seen under control conditions. Major seizures were suppressed only in adult rats with a 20 mg/kg dose; on the other hand, ORG 6370 exhibited a selective action against the tonic phase of major seizures at all stages of development. The profile of action of ORG 6370 is almost the same as that of phenytoin.
Mares
P
P
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Mirvaldová
H
H
Bĕlská
M
M
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D001952:Bridged-Ring Compounds; D003292:Convulsants; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D003292:Convulsants; C049281:5,6,9,10-tetrahydro-N,N-dimethyl-5,9-methanobenzocycloocten-11-amine; D010433:Pentylenetetrazole