[Long-term effects of indapamide in left ventricular hypertrophy in patients with hypertension].
Left ventricular hypertrophy is a major and independent cardiovascular risk factor in hypertension. The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. At the end of the trial, the left ventricular mass index decreased significantly from 172 +/- 11 to 147 +/- 11 g/m2 (p less than 0.001). Therefore, in contrast to the other diuretics which have been studied, indapamide seems able to induce regression of the left ventricular hypertrophy complicating hypertension.
Komajda
M
M
Hôpital Pitié-Salpêtrière, Paris.
Klimczak
K
K
Evans
J
J
Boutin
B
B
Brackman
F
F
Guez
D
D
Grosgogeat
Y
Y
D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007190:Indapamide
Effets à long terme de l'indapamide sur l'hypertrophie ventriculaire gauche de l'hypertendu.