title: Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes.
abstract: The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 micrograms/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.
authors: Departament de Genética i de Microbiologia, Universitat Autónoma de Barcelona, Spain.
authors: J
authors: J
authors: Surrallés
authors: E
authors: E
authors: Carbonell
authors: M
authors: M
authors: Puig
authors: N
authors: N
authors: Xamena
authors: A
authors: A
authors: Creus
authors: R
authors: R
authors: Marcos
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*
chemical_list: D000477:Alkylating Agents; D007306:Insecticides; D008937:Mitomycins; D009570:Nitriles; D011722:Pyrethrins; D016685:Mitomycin; C017690:fenvalerate