title: [The synthesis and anti-inflammatory properties of 7-theophyllineacetic acid derivatives].
abstract: Some esters of 7-theophyllinylacetic acid were synthetized, characterized physicochemically and tested for their anti-inflammatory properties. As compared to indomethacin, reference anti-inflammatory drug, all synthetized compounds were less toxic. The anti-inflammatory properties are influenced by the nature of the ester group radicals, the more active having ramified alchils.
authors: Facultatea de farmacie, Institutul de Medicină şi Farmacie Iaşi.
authors: G
authors: G
authors: Dănilă
authors: M
authors: M
authors: Ungureanu
authors: M
authors: M
authors: Pavelescu
authors: G
authors: G
authors: Rusu
authors: I
authors: I
authors: Sandu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002351:Carrageenan; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004952:Esters / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D007213:Indomethacin / Q000633:toxicity; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004952:Esters; D002351:Carrageenan; D013806:Theophylline; C019140:acefylline; D007213:Indomethacin
vernacular_title: Cercetări privind sinteza şi proprietăţile antiinflamatoare ale unor derivaţi ai acidului 7-teofilinilacetic.