title: Mechanisms of impaired excretion of a fluid load after cardiac denervation in dogs.
abstract: The influence of cardiac innervation on the renal response to volume expansion was investigated. Systemic hemodynamic, plasma hormone, and renal clearance measurements were made before, during, and after intravenous administration of 1,000 ml 0.9% saline over 10 min to six control and six cardiac-denervated, chloralose-anesthetized mongrel dogs. Volume expansion resulted in a two- to threefold rise in plasma atrial natriuretic peptide (ANP) concentrations and a 50% rise in glomerular filtration rate (GFR) in both groups. Plasma renin activity (PRA) and plasma arginine vasopressin remained higher throughout in cardiac-denervated compared with control dogs. The marked increases in urine flow rate and sodium and free water clearances seen in the controls were attenuated or abolished after cardiac denervation. These differences were due to the influence of higher PRA and vasopressin in these animals compared with the controls, rather than differences in hemodynamic responses operating via GFR or in direct humoral responses via ANP secretion.
authors: Department of Medicine, Charing Cross and Westminster Medical School, London, United Kingdom.
authors: T D
authors: TD
authors: Williams
authors: C M
authors: CM
authors: Travill
authors: M I
authors: MI
authors: Noble
authors: A J
authors: AJ
authors: Drake-Holland
authors: J
authors: J
authors: Chalmers
authors: C D
authors: CD
authors: Jeffery
authors: R
authors: R
authors: Sutton
authors: S L
authors: SL
authors: Lightman
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D003714:Denervation; D004285:Dogs; D006321:Heart / Q000294:innervation* / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000378:metabolism; D014554:Urination / Q000502:physiology*
chemical_list: D001127:Arginine Vasopressin; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor