t(2;18) and t(18;22) variant chromosomal translocations and bcl-2 gene rearrangements in human malignant lymphomas.
Most human follicular lymphomas bear the specific t(14;18) translocation that juxtaposes the 3' region of bcl-2 to the IgH gene on chromosome 14q+. In some rare cases, t(2;18) and t(18;22) translocations have been observed that involve bcl-2 and either Ig kappa or lambda genes. Strikingly, in these cases all the breakpoints on chromosome 18 are located in the 5' end the bcl-2 gene. These rearrangements are very similar to those recently found in a significant proportion of CLL. Thus, bcl-2 rearrangements in malignant lymphomas cluster in at least three regions: the so-called major breakpoint region (mbr) and minor cluster region (mcr) in more than 85% of t(14;18) translocation, and the newly characterized region 5' of the gene. We propose to call this new cluster region vcr (for variant cluster region).
Larsen
C J
CJ
Unité 301-INSERM, Institut de Génétique Moléculaire, Paris, France.
Mecucci
C
C
Leroux
D
D
D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure; D002887:Chromosomes, Human, Pair 18 / Q000648:ultrastructure*; D002889:Chromosomes, Human, Pair 2 / Q000648:ultrastructure*; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure*; D015321:Gene Rearrangement; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008223:Lymphoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2