An experimental study on prevention of postlaminectomy scar formation.
In repeat lumbar surgery for failed back syndrome, well organized fibrous scar tissue is often noted, binding together the dura, nerve roots, and paraspinal muscles. An animal experimental study was done to investigate the prevention of scar formation after lumbar laminectomy by using dacron and sodium hyaluronate. The experimental animals consisted of three groups: 1) control group, 2) D group (covering the laminectomy defect with dacron sheet), and 3) H group (covering the laminectomy defect with sodium hyaluronate gel). Animals were sacrificed at varying intervals (3-12 weeks) and the lumbar spines were evaluated with histologic preparations. Scar adhesion to the dura was most significantly suppressed in the D group, followed by the H group and the control group.
Lee
H M
HM
Department of Orthopaedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
Yang
K H
KH
Han
D Y
DY
Kim
N H
NH
D000818:Animals; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D003238:Connective Tissue / Q000473:pathology; D004195:Disease Models, Animal; D004388:Dura Mater / Q000473:pathology; D006820:Hyaluronic Acid; D007796:Laminectomy; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications; D011817:Rabbits; D013526:Surgical Mesh
D011093:Polyethylene Terephthalates; D006820:Hyaluronic Acid