Carboxyl terminal glycine extended progastrin (gastrin-G) in gastric antral mucosa of patients with gastric or duodenal ulcer and in gastrinomas.
Recently, carboxyl terminal glycine extended progastrin (gastrin-G), the immediate biosynthetic precursor of amidated gastrin, was found in human gastric antral mucosa. To investigate in pathophysiological conditions, we examined gastrin and gastrin-G levels and their molecular forms in gastric antral mucosa of healthy controls and patients with gastric or duodenal ulcer and in gastrinomas. There were no significant differences between controls and gastric or duodenal ulcer patients in antral gastrin and gastrin-G levels, the ratio of gastrin-G to gastrin and the pattern of their molecular forms. In contrast, gastrin and gastrin-G levels and the ratio of gastrin-G to gastrin in gastrinomas were much higher than those in antral mucosa of controls or ulcer patients. The predominant molecular form of gastrin-G was different between two Zollinger-Ellison syndrome (ZES) cases. These results suggest that there are no significant differences between healthy controls and patients with gastric or duodenal ulcer in the nature of gastrin amidation, and that the nature of gastrin amination in gastrinomas is different from that in normal gastrointestinal tissues.
Azuma
T
T
Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.
Magami
Y
Y
Habu
Y
Y
Kawai
K
K
Taggart
R T
RT
Walsh
J H
JH
D000328:Adult; D002850:Chromatography, Gel; D004381:Duodenal Ulcer / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry*; D015408:Gastrinoma / Q000737:chemistry*; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D008297:Male; D011498:Protein Precursors / Q000032:analysis*; D011863:Radioimmunoassay; D013276:Stomach Ulcer / Q000378:metabolism*; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism
D005755:Gastrins; D011498:Protein Precursors; C013706:big gastrin