title: Omega-dialkylaminoalkyl ethers of 3-exo-dialkylamino-(Z)-camphoroximes with antiarrhythmic and local anesthetic activities.
abstract: The synthesis of 3-exo-dialkylamino-(Z)-camphoroximes 7 starting from a mixture of 3-endo- and 3-exo-bromocamphornitrimine, hydroxylamine hydrochloride and excess secondary amine (dimethylamine, pyrrolidine, piperidine or morpholine) is described. Compounds 7 gave a series of omega-dialkylaminoalkyl ethers 9, 10 and 11 by reaction of 7 as sodium salts with omega-chloroalkyldialkylamines in DMF solution. Some of compounds 9, 10, 11 showed an appreciable antiarrhythmic and local anesthetic activity in rats and mice, respectively.
authors: Istituto di Scienze Farmaceutiche dell'Università Genova, Italy.
authors: A
authors: A
authors: Ranise
authors: F
authors: F
authors: Bondavalli
authors: O
authors: O
authors: Bruno
authors: P
authors: P
authors: Schenone
authors: G
authors: G
authors: Faillace
authors: A
authors: A
authors: Coluccino
authors: W
authors: W
authors: Filippelli
authors: A
authors: A
authors: Di Sarno
authors: E
authors: E
authors: Marmo
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002164:Camphor / Q000138:chemical synthesis* / Q000494:pharmacology; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000588:Amines; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D004987:Ethers; D010091:Oximes; D002164:Camphor