Severe hepatitis caused by cyproterone acetate.
A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug. The association between the use of cyproterone acetate and liver abnormalities is poorly documented. This is the fourth published report of adverse hepatic reaction to cyproterone acetate and it substantiates other evidence that cyproterone acetate is potentially hepatotoxic. Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.
Blake
J C
JC
Academic Department of Medicine, Royal Free Hospital School of Medicine, Hampstead, London.
Sawyerr
A M
AM
Dooley
J S
JS
Scheuer
P J
PJ
McIntyre
N
N
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000473:pathology; D003534:Cyproterone / Q000009:adverse effects* / Q000031:analogs & derivatives*; D017373:Cyproterone Acetate; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy
D017373:Cyproterone Acetate; D003534:Cyproterone; D001219:Aspartate Aminotransferases; D001663:Bilirubin