title: [A comparative evaluation of iodine-131 OIH and technetium-99m MAG3 in the study of renal function].
abstract: A new renal imaging agent, 99mTc mercaptoacetyltriglycine (MAG3), has been recently proposed in the nuclear medicine evaluation of renal function. Just like 131 orthoiodohippurate (OIH), 99mTc MAG3 is removed mainly by the renal tubules. An heterogeneous group of 39 patients underwent a radioisotopic study with the simultaneous injection of OIH (131I) and 99mTc MAG3. Image quality was found to be better with 99mTc MAG3 than with OIH (131I), because the former always allowed renal regions of interest (ROI) to be clearly demonstrated, even in case of severe renal impairment. A quantitative analysis was also carried out: effective renal plasma flow (ERPF) values were compared with renographic peak times evaluated by using both radiotracers. Our results demonstrate a firm correlation to exist between the informative content yielded by 99mTc MAG3 and by OIH (131I). Absolute ERPF value was higher with MAG3, but the correlation index (r = 0.98) allowed a simple correction factor to be introduced. In conclusion, MAG3 appears to be a good alternative to OIH.
authors: Servizio di Medicina Nucleare e Radioterapia, Ospedale Civile, Sondrio.
authors: I
authors: I
authors: Di Lorenzo
authors: F
authors: F
authors: Stiglich
authors: C
authors: C
authors: Barbonetti
authors: F
authors: F
authors: Bonomo
authors: S
authors: S
authors: Maspero
authors: S
authors: S
authors: Paini
authors: G
authors: G
authors: Bottinelli
mesh_terms: D005069:Evaluation Studies as Topic; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography / Q000295:instrumentation / Q000379:methods*; D012079:Renal Circulation; D017263:Technetium Tc 99m Mertiatide
chemical_list: D007457:Iodine Radioisotopes; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide
vernacular_title: Valutazione comparata di Iodio-131 OIH e Tecnezio-99m MAG3 nello studio della funzionalità renale.