title: Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
abstract: The potential antidepressant dihydroergosine enhanced the convulsive properties of picrotoxin and bicuculline in rats and diminished them in mice. The possibility of dihydroergosine modulating species-dependently GABA/benzodiazepine receptors is suggested.
authors: Department of Experimental Biology and Medicine, Rudjer Bosković Institute, Zagreb, Yugoslavia.
authors: D
authors: D
authors: Pericić
authors: H
authors: H
authors: Manev
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001640:Bicuculline; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004879:Ergotamines / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010852:Picrotoxin; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D013045:Species Specificity
chemical_list: D000928:Antidepressive Agents; D001640:Bicuculline; D004879:Ergotamines; D010852:Picrotoxin; D011963:Receptors, GABA-A; C037580:9,10-dihydroergosine