[Pathogenesis of bacterial respiratory infection and new approach of the treatment].
Causative agents of respiratory infections has been changed because of increase in number of aged people and compromised host and the rapid development of new chemotherapeutic agents. Especially Branhamella catarrhalis (B. catarrhalis), which is very unique and has become a common respiratory pathogen, since 1980, in my department. Attachment ability of B. catarrhalis to oropharyngeal cells coincided with the acute exacerbation of chronic respiratory infections by this bacterium and the same phenomenon in pneumococcal infections was also established. In the hospital for aged people, two major pathogens Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) are specially seen. In these patients, the two major ones were isolated from the oropharynx. Non-typable Haemophilus influenzae (H. influenzae) is also very important in Japan like USA. Recurrent infection with this pathogen occurred due to the change of OMPs during the time period of more than one month. Complement and some amount of ceftadizim were inactivated by destroyed neutrophils in vitro. This result may explain one of the cause of intractability of P. aeruginosa infection. Monoclonal antibody against P. aeruginosa showed effectiveness in P. aeruginosa pneumonia model in mice. Intraabdominal administration of fibronectin also was effective for staphylococcal pneumonia in rat. Oropharyngeal pathogens like S. aureus, S. pneumonia, B. catarrhalis, H. influenzae and P. aeruginosa were killed by 100-500 times diluted solution of 7% povidonjod solution. Moreover the frequency of recurrence of infection by these bacteria were decreased by gargling this solution 3-4 times/day.(ABSTRACT TRUNCATED AT 250 WORDS)
Matsumoto
K
K
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University.
D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion; D002648:Child; D006193:Haemophilus influenzae / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D001936:Moraxella catarrhalis / Q000302:isolation & purification / Q000472:pathogenicity*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000472:pathogenicity; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity