title: [Prevention of caries with lactobacillus (final results of a clinical trial on dental caries with killed lactobacillus [streptococcus and lactobacillus] given orally)].
abstract: Caries prevention with lactic bacteria. (Final results of a dental caries clinical trial using heat killed lactic bacteria [streptococci and lactobacilli] orally.) The results of a dental caries clinical trial in 245 seven-year-old children are reported. Chewable tablets of two different types were prepared: A) Containing pyridoxine (Vit. B6) and heat killed lactic bacteria. B) Placebo tablets with pyridoxine only. They were randomly given once a week for 16 weeks to experimental and control groups respectively. Four evaluation surveys were conducted during 24 months of follow up, using the "Decay, Missing, Filled, Surfaces" index (DMFS) for the clinical evaluation of the permanent teeth. A consistent reduction in the incidence of dental caries in the experimental group was observed in all 4 surveys. After 2 years of follow up a 42% reduction in the incidence rate of dental caries was observed in the experimental group compared to the control group. Summary tables and discussion of the clinical evaluation surveys are given. The potential use of these clinical findings as support for a future dental caries vaccine evaluation project is proposed.
authors: Universidad Nacional Autónoma de Mexico (UNAM), Ciudad de Mexico.
authors: A
authors: A
authors: Bayona González
authors: V
authors: V
authors: López Cámara
authors: A
authors: A
authors: Gómez Castellanos
mesh_terms: D001428:Bacterial Vaccines; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000276:immunology / Q000517:prevention & control*; D006358:Hot Temperature; D006801:Humans; D007778:Lactobacillus; D013294:Lactococcus lactis; D011736:Pyridoxine / Q000627:therapeutic use; D015164:Vaccines, Inactivated
chemical_list: D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated; D011736:Pyridoxine
vernacular_title: Prevención de caries por lactobacilos (resultados finales de un ensayo clínico sobre caries dental con lactobacilos muertos [estreptococos y lactobacilos] por vía oral).