Lupus anticoagulant.
Lupus anticoagulants have been recognized as significant causes of morbidity in patients for many years. They were originally regarded by physicians and researchers as a nuisance. However, the name is a misnomer that has resisted change over the years. The riddle of the anticoagulant effect in vitro and the apparent procoagulant effect in vivo remains unsolved. Since a lupus anticoagulant can exist in virtually every patient population, it is no longer a topic of interest limited only to the hematologists, but has achieved multidisciplinary attention. The presence of a lupus anticoagulant should be evaluated in any patient who presents with new onset transient ischemic attack or cerebral vascular accident, unexplained deep venous thrombosis, or recurrent fetal wastage.
Williams
P E
PE
Department of Medicine, UAMS, Little Rock.
D000026:Abortion, Habitual / Q000097:blood; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001779:Blood Coagulation Factors / Q000276:immunology* / Q000378:metabolism; D002545:Brain Ischemia / Q000097:blood; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008297:Male; D011247:Pregnancy; D013924:Thrombophlebitis / Q000097:blood
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor