title: Measurement of splanchnic circulation in dogs: changes induced by prostaglandin E1.
abstract: In seven anesthetized dogs the effects of intravenously administered prostaglandin E1 on mesenteric arterial and portal venous blood flows and pancreatic capillary blood flow were measured with a transit-time ultrasonic volume flowmeter and a laser Doppler flowmeter. Basal blood flow of the superior mesenteric artery and of the portal vein were 5.7 +/- 0.6 and 11.2 +/- 1.0 ml/min/kg, respectively. Prostaglandin E1 caused a dose-dependent increase in these blood flows. The maximal effect was observed at a dose of 1.0 microgram/kg, when the superior mesenteric arterial blood flow increased 117.9 +/- 3.2% and the portal venous blood flow increased 99.4 +/- 1.7%. Prostaglandin E1 produced an initial rapid increase, followed by a decrease in pancreatic capillary blood flow. The results indicate that the flowmeters used in the present study are widely available for the study of splanchnic circulation and may have a possibility for clinical application.
authors: First Dept. of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors: R
authors: R
authors: Doi
authors: K
authors: K
authors: Inoue
authors: M
authors: M
authors: Kogire
authors: S
authors: S
authors: Sumi
authors: T
authors: T
authors: Tobe
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D004285:Dogs; D005260:Female; D007834:Lasers; D008297:Male; D012212:Rheology; D013152:Splanchnic Circulation / Q000187:drug effects*; D014463:Ultrasonography
chemical_list: D000527:Alprostadil