Acute visual disorders in patients on regular dialysis given desferrioxamine as a test.
Aluminium (Al) overload has been recognised as a frequent complication in uraemic patients on regular dialysis treatment. We report how acute visual disorders occurred after performing a desferrioxamine (DFO) test in patients on regular dialysis treatment suspected of having aluminium overload. Fifteen patients on regular dialysis treatment for 132 +/- 73 (range 17-250) months, aged 61 +/- 10 (range 47-79) years were given DFO as a test at standard dosage. In the 13 patients who complained of visual disorders, we performed ophthalmologic examinations soon after DFO administration, and again 5 months later in 11 of them. A decrease in visual acuity and/or dyschromatopsia, transient or permanent, were present in ten patients. Four had permanent maculopathy and three also had a permanent alteration of VEP (visual evoked potential). Visual fields were normal in all patients except one who presented a permanent central scotoma. The EOG (electro-oculogram) was permanently impaired in five patients and some of them had fluoroangiographic alterations due to damage of the pigmented epithelium. Six to eight months after the DFO test four patients still complained of visual acuity reduction. We conclude that there is a high rate of visual disorders after giving DFO at the standard doses; therefore we stress the need to modify the doses commonly used and/or the mode of infusion.
Ravelli
M
M
Department of Nephrology, University of Brescia, Italy.
Scaroni
P
P
Mombelloni
S
S
Movilli
E
E
Feller
P
P
Apostoli
P
P
De Maria
G
G
Valotti
C
C
Sciuto
G
G
Maiorca
R
R
D000368:Aged; D000535:Aluminum / Q000633:toxicity; D003676:Deferoxamine / Q000009:adverse effects*; D005123:Eye / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009799:Ocular Physiological Phenomena; D009900:Optic Nerve / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects*; D014786:Vision Disorders / Q000139:chemically induced*; D014792:Visual Acuity / Q000187:drug effects
D000535:Aluminum; D003676:Deferoxamine