Inflammatory reactions induced by various calcium pyrophosphate crystals.
Various inflammatory reactions can be induced by different crystals responsible for various arthropathies. The aim of this work was to study modifications induced in the rat, locally and at distance, by intrapleural injection of 3 forms of pyrophosphate crystals (CaPP dihydrated monoclinic (M), CaPP dihydrated triclinic (T) and CaPP anhydrous (beta]. The data presented here show that the structure of irritants plays a decisive role in the kinetics of inflammatory reactions from a local and systemic point of view.
Roch-Arveiller
M
M
Département de Pharmacologie, CNRS UA 595, Paris, France.
Legros
R
R
Chanaud
B
B
Muntaner
O
O
Strzalko
S
S
Thuret
A
A
Willoughby
D A
DA
Giroud
J P
JP
D000210:Acute-Phase Reaction / Q000139:chemically induced* / Q000378:metabolism; D000818:Animals; D002131:Calcium Pyrophosphate / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D003460:Crystallization; D007267:Injections; D010994:Pleura / Q000473:pathology; D010998:Pleurisy / Q000139:chemically induced / Q000473:pathology; D051381:Rats
D002131:Calcium Pyrophosphate