A plasmid-encoded anion-translocating ATPase.
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.
Rosen
B P
BP
Department of Biochemistry, Wayne State University, School of Medicine, Detroit, MI 48201.
Hsu
C M
CM
Karkaria
C E
CE
Kaur
P
P
Owolabi
J B
JB
Tisa
L S
LS
D000251:Adenosine Triphosphatases / Q000235:genetics*; D053501:Arsenite Transporting ATPases; D004926:Escherichia coli / Q000235:genetics; D016623:Ion Pumps; D009097:Multienzyme Complexes; D009876:Operon; D010957:Plasmids / Q000235:genetics*
D016623:Ion Pumps; D009097:Multienzyme Complexes; D000251:Adenosine Triphosphatases; D053501:Arsenite Transporting ATPases