title: Quantitative shape analysis of the temporal and prefrontal lobes of schizophrenic patients: a magnetic resonance image study.
abstract: In a recent quantitative neuroimaging study, the authors reported significant reduction in the gray matter volume of both temporal lobes of schizophrenic (SC) patients. In order to better elucidate the nature of this finding (i.e., diffuse vs. focal), we analyzed the shape of the temporal lobes of 17 SC patients and an equal number of age-sex matched controls. Our shape analysis was able to discriminate between a significant number of SC and control patients based on the Fourier harmonic amplitudes of both the middle and posterior levels of the temporal lobes. These results are consistent with bilateral focal or multifocal distortions of the temporal lobes of SC patients. A similar shape analysis of the prefrontal lobes showed no significant conformational differences between the groups. The basis of this quantitative shape analysis (the Fourier expansion series) and the method by which it can be applied are explained in detail.
authors: Clinical Brain Disorders Branch, National Institute of Mental Health.
authors: M F
authors: MF
authors: Casanova
authors: T E
authors: TE
authors: Goldberg
authors: R L
authors: RL
authors: Suddath
authors: D G
authors: DG
authors: Daniel
authors: R
authors: R
authors: Rawlings
authors: D G
authors: DG
authors: Lloyd
authors: H L
authors: HL
authors: Loats
authors: J E
authors: JE
authors: Kleinman
authors: D R
authors: DR
authors: Weinberger
mesh_terms: D001284:Atrophy; D001931:Brain Mapping / Q000295:instrumentation; D005260:Female; D005583:Fourier Analysis; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000473:pathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000473:pathology*