Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes.
The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 micrograms/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.
Surrallés
J
J
Departament de Genética i de Microbiologia, Universitat Autónoma de Barcelona, Spain.
Carbonell
E
E
Puig
M
M
Xamena
N
N
Creus
A
A
Marcos
R
R
D000477:Alkylating Agents / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*
D000477:Alkylating Agents; D007306:Insecticides; D008937:Mitomycins; D009570:Nitriles; D011722:Pyrethrins; D016685:Mitomycin; C017690:fenvalerate