Acute megakaryoblastic leukemia in Down syndrome, following thrombocytopenia with antiplatelet antibody.
We report a case of acute megakaryoblastic leukemia (AMKL) with antiplatelet antibody in a boy with Down syndrome. When the patient was admitted, his platelet count was 1.3 X 10(4)/mm3 and antiplatelet antibody in the plasma was detected. Two months after admission, blasts, which showed positive reaction to both antiplatelet monoclonal antibody and platelet peroxidase, increased.
Sumi
S
S
Department of Pediatrics, Nagoya City University Medical School.
Obayashi
M
M
Murakami
M
M
Ito
J
J
Okada
N
N
Shibata
Y
Y
D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications* / Q000276:immunology; D008297:Male; D011289:Preleukemia / Q000150:complications / Q000276:immunology; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology; D013997:Time Factors
D001323:Autoantibodies