Anti-CD3 murine monoclonal isotype switch variants tested for toxicity and immunologic monitoring in four chimpanzees.
Parleviet
K J
KJ
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Jonker
M
M
ten Berge
R J
RJ
van Lier
R A
RA
Wilmink
J M
JM
Strengers
P F
PF
Aarden
L A
LA
Schellekens
P T
PT
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D000943:Antigens, Differentiation / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D007132:Immunoglobulin Isotypes / Q000009:adverse effects*; D007134:Immunoglobulin Switch Region / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008213:Lymphocyte Activation / Q000276:immunology; D008212:Lymphocyte Depletion; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D051379:Mice; D016853:Muromonab-CD3; D002679:Pan troglodytes; D011961:Receptors, Fc / Q000276:immunology; D017452:Receptors, IgG
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D016207:Cytokines; D007132:Immunoglobulin Isotypes; D007166:Immunosuppressive Agents; D016853:Muromonab-CD3; D011961:Receptors, Fc; D017452:Receptors, IgG