Oncogenes and anti-oncogenes in tumorigenesis.
Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phenotype is dominant. The anti-oncogenes or tumor suppressor genes or recessive oncogenes are normally implicated in a negative regulation of cellular proliferation. The loss of their activity contributes to tumorigenesis in a recessive manner. Genetic events activating proto-oncogenes or inactivating anti-oncogenes accumulate in the same cell during tumor progression and co-operate to determine the malignant invasive phenotype of advanced tumors.
Monier
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Institut Gustave-Roussy, UA CNRS 1158, Laboratoire d'Oncologie moléculaire, Villejuif, France.
D002454:Cell Differentiation; D002455:Cell Division; D015972:Gene Expression Regulation, Neoplastic; D005808:Genes, Recessive; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics; D009857:Oncogenes; D010750:Phosphoproteins / Q000235:genetics; D011519:Proto-Oncogenes; D012175:Retinoblastoma / Q000235:genetics; D016159:Tumor Suppressor Protein p53
D015513:Oncogene Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53