title: Lack of effect of dehydroepiandrosterone in obese men.
abstract: To assess the effects of dehydroepiandrosterone (DHEA) on weight and body fat mass in young obese men, six obese (body mass index, 31.5 +/- 2.9 (s.e.] men were studied at baseline, after 28 days of placebo administration, and again after 28 days of DHEA (1600 mg/day) administration. Body fat mass was assessed on each occasion by three separate methods: hydrostatic weighing, impedance plethysmography, and skinfold measurements at four body sites. Waist-to-hip ratios were recorded. In addition, tissue sensitivity to insulin was determined using the modified minimal model technique, and serum lipids were assayed. Serum DHEA-sulfate levels rose from 7.4 +/- 1.7 mumol/l at baseline to 39.8 +/- 11.9 mumol/l after DHEA administration (P less than 0.05). Although body fat mass was reduced in two of the six men following DHEA administration, for the group as a whole neither total body weight, body fat mass, or waist-to-hip ratio changed significantly during the study. No change in either tissue insulin sensitivity or serum lipids was observed. These observations suggest that, at a daily dose of 13.4-19.7 mg/kg, short-term DHEA administration does not affect the total weight, body fat mass, fat distribution, insulin sensitivity, or lipid status of obese young men.
authors: Department of Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
authors: K S
authors: KS
authors: Usiskin
authors: S
authors: S
authors: Butterworth
authors: J N
authors: JN
authors: Clore
authors: Y
authors: Y
authors: Arad
authors: H N
authors: HN
authors: Ginsberg
authors: W G
authors: WG
authors: Blackard
authors: J E
authors: JE
authors: Nestler
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015992:Body Mass Index; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D007328:Insulin; D008055:Lipids; D003687:Dehydroepiandrosterone