Fluorescent detection of rabbit endometrial implants resulting from monodispersed viable cell suspensions.
A model for early stage endometriosis was prepared in rabbits by intraperitoneal injection of monodispersed viable endometrial cells. With this model, we have found that DHE fluorescence increases the sensitivity of detection of endometrial tissue. The potential experimental and clinical significance of ectopic endometrial detection by porphyrin fluorescence is enhanced by the recent report of endometrial transplant destruction by PDT. Although caution must be exercised for extrapolation from animal experiments to human conditions, these results encourage further evaluation of photosensitization for the study and potential treatment of disorders involving endometrial tissue.
Manyak
M J
MJ
Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland.
Nelson
L M
LM
Solomon
D
D
DeGraff
W
W
Stillman
R J
RJ
Russo
A
A
D000818:Animals; D001706:Biopsy; D002470:Cell Survival; D003584:Cytological Techniques; D017323:Dihematoporphyrin Ether; D004717:Endometrium / Q000166:cytology / Q000473:pathology / Q000637:transplantation*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005453:Fluorescence; D006415:Hematoporphyrins; D007274:Injections, Intraperitoneal; D011817:Rabbits
D006415:Hematoporphyrins; D017323:Dihematoporphyrin Ether