Absence of abnormalities of the c-erbB-1 and c-erbB-2 proto-oncogenes in human thyroid neoplasia.
The c-erbB-1 and c-erbB-2 proto-oncogenes are frequently activated by gene amplification and overexpression in a variety of human cancers. In an analysis of a large series of benign and malignant thyroid tumours, no abnormalities of structure or expression of either of c-erbB-1 or c-erbB-2 were found. Activation of these oncogenes is not a necessary event in neoplasia of this epithelial system.
Lemoine
N R
NR
ICRF Molecular Oncology Group, Hammersmith Hospital, London, U.K.
Wyllie
F S
FS
Lillehaug
J R
JR
Staddon
S L
SL
Hughes
C M
CM
Aasland
R
R
Shaw
J
J
Varhaug
J E
JE
Brown
C L
CL
Gullick
W J
WJ
D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D015870:Gene Expression; D015321:Gene Rearrangement; D006801:Humans; D009841:Oligonucleotides / Q000032:analysis; D011519:Proto-Oncogenes; D013964:Thyroid Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D009841:Oligonucleotides