[Research on malaria vaccine].
Malaria is an important public health problem in developing countries. The production of a good vaccine needs a better knowledge of different mechanisms which control the immune system. Results from donors show a higher frequency of antigens HLA: A2, B35, CW4, CW6, DRW52, DQW1 and DQW3. The lymphoproliferation in vitro of mononuclear cells, T cells and CD4+ and CD8+ subsets T cells with merozoite extracts is not so clear to establish a correlation between HLA phenotypes and T cells response.
Dieye
A
A
Laboratoire d'Immunologie cellulaire, Institut Pasteur Dakar.
Launois
P
P
Sarthou
J L
JL
D000328:Adult; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008213:Lymphocyte Activation; D016778:Malaria, Falciparum / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014612:Vaccines
D000953:Antigens, Protozoan; D006680:HLA Antigens; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D014612:Vaccines
Perspectives de recherche sur la vaccination antipaludique.