[Immunization against blood group antigens by allogeneic bone transplantation].
33 bone allotransplants (cryopreserved) of AB0- and Rh-incompatible (donor-recipient) patients were performed to evaluate the question which AB0 Rh-incompatibility leads to immunization of the bone transplant recipient. Several different antibodies were tested pre- and postoperatively in the recipient. Regarding the Rh-system no immunization was demonstrable; however, a significant increase of antibody leads was found regarding the AB0-system. Thus, in bone bank techniques AB0 compatibility is important for allogeneic bone transplantation in young women. Otherwise, there is a risk for the development of MHN in case of pregnancy. Blood group-typing is not necessary in other patient groups. Although no Rh-antibodies were demonstrable, a similar mechanism can be postulated for the Rh-system. We, thus, conclude that in allogeneic bone tx in young women the Rh-system has to be taken into consideration.
Knaepler
H
H
Klinik für Unfallchirurgie, Philipps-Universität Marburg/Lahn.
Ascherl
R
R
Kretschmer
V
V
D000017:ABO Blood-Group System / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001787:Blood Group Incompatibility / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D001788:Blood Grouping and Crossmatching; D016025:Bone Transplantation / Q000009:adverse effects; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D014019:Tissue Donors
D000017:ABO Blood-Group System; D007518:Isoantibodies; D007519:Isoantigens
Immunisierung gegen Blutgruppenantigene durch allogene Knochentransplantation.