Effect of the new spacer-device on the deposition of the inhaled metered dose aerosol.
The effect of the new spacer-device on the in vitro and in vivo deposition of inhaled drug particles was studied. The in vitro deposition of beclomethasone dipropionate 250 micrograms/dose aerosol administered either through the conventional aerosol actuator with the short plastic mouthpiece or through the new pear-shaped spacer-device was evaluated with the modified cascade impactor method. For the in vivo study the disodium cromoglycate particles were labelled with a pure gamma-radiator 99mTc using a coprecipitation technique based on spray drying. The deposition of the inhaled disodium cromoglycate particles in the human respiratory tract after administration of the drug doses from the devices tested was determined by means of a gamma camera. The new spacer-device increased both in the in vitro and in vivo tests the fraction of the drug dose deposited into the therapeutically significant regions of the respiratory tract. In addition, the therapeutically insignificant fraction deposited in the upper airways and mouth clearly decreased. Thus using the new spacer-device evaluated in this study the local side effects would be decreased.
Vidgren
M
M
Orion Pharmaceutica, Department of Pharmaceutical Technology, University of Kuopio, Finland.
Paronen
P
P
Vidgren
P
P
Nuutinen
J
J
Vainio
P
P
D000336:Aerosols / Q000008:administration & dosage*; D001507:Beclomethasone / Q000378:metabolism; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D009330:Nebulizers and Vaporizers; D011877:Radionuclide Imaging; D013667:Technetium
D000336:Aerosols; D013667:Technetium; D001507:Beclomethasone; D004205:Cromolyn Sodium