Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location.
We have isolated and sequenced the gene encoding the human embryonic/atrial myosin alkali light chain isoform (MLC-1emb/A). The gene is split into seven exons by six introns; the last exon, as in all MLC isoform genes sequenced to date, is completely 3' untranslated sequence. Comparison of the MLC-1emb/A isoform gene with the other MLC-1 genes showed that the exon-intron arrangement of the human MLC-1emb/A isoform gene is analogous to that of the other MLC-1 type isoform genes. We have also mapped the human MLC-1emb/A isoform gene to the long arm of chromosome 17; the corresponding mouse gene has been mapped to chromosome 11. This gene, together with a number of others such as the collagen(I) alpha 1, galactokinase, and thymidine kinase genes, is part of the largest syntenic group between mouse and man.
Seharaseyon
J
J
Department of Neurology, Ohio State University, Columbus 43210.
Bober
E
E
Hsieh
C L
CL
Fodor
W L
WL
Francke
U
U
Arnold
H H
HH
Vanin
E F
EF
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002875:Chromosomes; D002886:Chromosomes, Human, Pair 17; D005091:Exons; D006801:Humans; D006822:Hybrid Cells; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D009218:Myosins / Q000235:genetics*
D009218:Myosins