Changes in the properties of plasma fibronectin in Shigella-induced endotoxaemia and the responses to hyperbaric oxygenation and indomethacin.
In rabbits, Shigella endotoxin causes hypoxaemia, metabolic acidosis, and hypocapnia. These changes are more marked at a dose of 1 mg kg-1 than with one of 0.5 mg kg-1 body weight. The endotoxin also reduces the plasma level and heparin-binding activity of fibronectin (FN). During convalescence, FN activity recovers at a slower rate than its level. Hyperbaric oxygenation (HBO; 2 atm for 1 h) normalizes blood gas composition and acid-base and electrolyte balance, improves the clinical picture of endotoxaemia, enhances FN activity and, to a lesser degree, its concentration, and lowers mortality. Indomethacin (IN) (5 mg kg-1 orally) has a similar action. When HBO and IN are used in combination, there is no enhancement of the therapeutic effect and mortality increases.
Bogin
I B
IB
First Moscow Sechenov Medical Institute.
Belavina
M V
MV
Koloskov YuB
Demurov
E A
EA
Leonova
S F
SF
Khitrov
N K
NK
Efuni
S N
SN
D000818:Animals; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D005353:Fibronectins / Q000097:blood*; D006493:Heparin / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012764:Shigella sonnei; D014115:Toxemia / Q000097:blood*
D004731:Endotoxins; D005353:Fibronectins; D006493:Heparin; D002118:Calcium; D007213:Indomethacin