Pyrrolidone-carboxylic acid magnesium salt (PCA-Mg2+) protects against seizures induced by excitatory amino acids.
Single administration of PCA-Mg2+ (200 mg/kg, s.c.) increased the latency and shortened the duration of seizures produced by systemic injection of N-methyl-D-aspartate (NMDA) in mice. Mortality was reduced in mice pretreated with PCA-Mg2+. Single or repeated (twice a day for 5 days) injections of PCA-Mg2+ (250 mg/kg, i.p.) also attenuated kainate-induced seizures in rats. However, PCA-Mg2+ had no effect on kainate-induced automatisms but reduced the frequency of generalized seizures. These results indicate that pharmacological doses of Mg2+ protect experimental animals against excitatory amino acid-induced seizures.
Canonico
P L
PL
Institute of Pharmacology, University of Catania, Italy.
Aronica
E
E
Bruno
V
V
Catania
M V
MV
Aleppo
G
G
Galavotti
F
F
Nicoletti
F
F
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects; D007608:Kainic Acid / Q000008:administration & dosage; D007696:Kindling, Neurologic / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D016194:Receptors, N-Methyl-D-Aspartate; D008274:Magnesium; D007608:Kainic Acid; D011761:Pyrrolidonecarboxylic Acid