title: The role of non-B cells in localizing an IgA plasma cell response in the intestine.
abstract: We have demonstrated previously that when autologous cells are re-infused into rats which had been primed via gut-associated lymphoid tissue (GALT) and given lumenal challenge, extravasation of IgA-committed plasma cell precursors in the intestinal lamina propria is an antigen-independent event, but their distribution after extravasation is influenced by the site of lumenal challenge. We report in this article, however, that when IgA plasma cell precursors are adoptively transferred from primed and challenged donors to syngeneic recipients given only lumenal challenge, localization in the intestinal lamina propria does not occur. This indicates that factors other than antigen are required for effective localization of IgA cells. The role of a cellular factor in directing their localization in the gut is demonstrated here by the ability of prior infusion of a B cell-depleted inoculum from immunized donors to encourage localization of adoptively transferred IgA cells in nonimmunized recipients. We suggest that T cells play a role in IgA plasma cell localization, possibly by producing a cytokine environment in the lamina propria conductive to maturation and/or proliferation of extravasated IgA plasma cell precursors.
authors: Faculty of Medicine, University of Newcastle, NSW, Australia.
authors: M L
authors: ML
authors: Dunkley
authors: A J
authors: AJ
authors: Husband
mesh_terms: D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D007070:Immunoglobulin A / Q000378:metabolism*; D007422:Intestines / Q000166:cytology / Q000276:immunology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013234:Stem Cells / Q000276:immunology
chemical_list: D000941:Antigens; D007070:Immunoglobulin A; D010047:Ovalbumin