[Platelet aggregation induced by fibrinmonomer and the effect of the heparin-adrenaline complex or plasmin on this process].
Addition of purified fibrin-monomer in a concentration of 0.5 mg/ml induces aggregation in a suspension of washed rat platelets in the absence of aggregants. Maximum aggregation takes place 1-3 min after fibrin-monomer addition, and then the disaggregation phase follows. Complex heparin compounds with adrenalin or plasmin possessing antipolymerization and fibrinolytic activity with respect to ++non-stabilized fibrin prevent, or to a great extent decrease fibrin-monomer-induced aggregation of washed platelets.
Pastorova
V E
VE
Liapina
L A
LA
Kudriashov
B A
BA
Lugovskoĭ
E V
EV
D000818:Animals; D004338:Drug Combinations; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005338:Fibrin Fibrinogen Degradation Products / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005341:Fibrinolysin / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D004338:Drug Combinations; D005338:Fibrin Fibrinogen Degradation Products; D010975:Platelet Aggregation Inhibitors; C011468:fibrinmonomer; D006493:Heparin; D005341:Fibrinolysin; D004837:Epinephrine
Agregatsiia trombotsitov, vyzyvaemaia fibrin-monomerom, i vliianie kompleksnykh soedineniĭ geparina s adrenalinom ili plazminom na étot protsess.