title: Effects of dietary protein on composition and metabolism of plasma lipoproteins in rabbits.
abstract: Changes in the concentration and composition of serum VLDL, LDL, and HDL were studied in rabbits transferred from Chow diets to cholesterol-free, semipurified diets containing casein or isolated soy protein. During the first week on the casein diet, there was a marked increase in LDL-cholesterol and these higher levels were maintained during the subsequent 3 weeks of the study. Similar but less marked changes were obtained with the soy protein diet. When the percent composition of the particles was determined, both VLDL and LDL had a higher proportion of cholesterol. Turnover studies indicated that the FCRs for radiolabelled VLDL and LDL were reduced in casein-fed animals compared to those fed soy protein. The elevated LDL levels in casein-fed rabbits were primarily due to a reduction in receptor-mediated catabolism of LDL-apo B. Receptor-independent removal in the two groups was similar. These studies show that the hypercholesterolemia in casein-fed rabbits, compared to those fed soy protein, is associated with cholesterol enrichment of LDL and impaired receptor-dependent removal of LDL-apo B.
authors: Department of Biochemistry, University of Western Ontario, London, Canada.
authors: S
authors: S
authors: Samman
authors: E M
authors: EM
authors: Kurowska
authors: P
authors: P
authors: Khosla
authors: K K
authors: KK
authors: Carroll
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000097:blood; D002364:Caseins / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004044:Dietary Proteins / Q000494:pharmacology*; D007700:Kinetics; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D014674:Plant Proteins, Dietary / Q000494:pharmacology; D011817:Rabbits; D030262:Soybean Proteins
chemical_list: D001055:Apolipoproteins B; D002364:Caseins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004044:Dietary Proteins; D008074:Lipoproteins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D002784:Cholesterol