Effect of cyproterone acetate on testis of albino rats: ultrastructural and biochemical approach.
The animals were treated with cyproterone acetate (1 mg/100 g body weight) for 60 days after which the testicular tissue was studied at the ultrastructural level to determine the stage at which the effect took place and to study the magnitude of the effect. The testis showed changes in Sertoli cells, Leydig cells, germ cells and in the spermatids. To correlate these changes, important marker enzymes and other biochemical parameters essential for spermatogenesis were studied after 30 days and 60 days of the treatment. They registered a decrease in their levels as compared with the controls.
Bhiwgade
D A
DA
Department of Zoology, Institute of Science, Bombay, India.
Menon
S N
SN
Avari
K M
KM
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D007985:Leydig Cells / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000187:drug effects / Q000648:ultrastructure; D013737:Testis / Q000187:drug effects / Q000648:ultrastructure*
D000726:Androgen Antagonists; D017373:Cyproterone Acetate; D003534:Cyproterone