Introductory remarks about clinically relevant pharmacokinetic properties of organic nitrates.
As an introduction to a round-table discussion on nitrate therapy, clinical pharmacokinetics of organic nitrates are briefly summarized. After some remarks about the assay methods, the main pharmacokinetic data are briefly reviewed, as are the plasma concentrations obtained after different formulations. Finally, the problem of the lack of relationship between nitrate plasma concentrations and their effect is stressed.
Bogaert
M
M
J.F. & C. Heymanns Institut für Pharmakologie, Universität Gent, Belgium.
D000279:Administration, Cutaneous; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007262:Infusions, Intravenous; D009566:Nitrates / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005996:Nitroglycerin / Q000493:pharmacokinetics / Q000627:therapeutic use
D009566:Nitrates; D005996:Nitroglycerin