Pathogen-host interaction.
Host defense, as it generally applies to humans, refers to the individual's ability to withstand infections. Human host defense mechanisms are numerous, diversified, complex, and often interdependent. The administration of drugs may influence some phases of immunocompetence mechanisms. The effect of several antimicrobial agents on organic defenses has been studied. The parameters considered were chemotaxis, phagocytosis, intracellular killing, superoxide-anion production, antibody production, lymphocyte subset behavior, and natural killer cell activity. Some antibacterial agents inhibit these parameters, whereas others can enhance some of these immune parameters to differing extents. Some antibacterial agents have a neutral effect on these parameters.
Fraschini
F
F
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Falchi
M
M
Cattaneo
G
G
Aimini
R
R
Maierna
G
G
Nebuloni
R
R
Scaglione
F
F
Cortelazzi
R
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D002633:Chemotaxis / Q000187:drug effects; D004198:Disease Susceptibility / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects; D018942:Macrolides; D015201:Meta-Analysis as Topic; D010587:Phagocytosis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D018942:Macrolides