Treatment of onychomycosis with a bifonazole-urea combination.
A clinical trial has been conducted to assess the efficacy of 1% bifonazole and 40% urea ointment for 2 weeks followed by 1% bifonazole cream for one month in the topical treatment of onychomycosis. Thinning and total avulsion of the nails occurred in 97% of 30 patients with candidal onychomycosis and regrowth of a normal appearing nail was found in 92% of 26 patients. Failure rate was 4% and recurrence rate was 12% in 26 patients. Results of the treatment was followed up for 12 weeks. Side effects were negligible.
Hardjoko
F S
FS
Department of Dermato-Venereology, Gatot Soebroto Central Army Hospital, Jakarta, Indonesia.
Widyanto
S
S
Singgih
I
I
Susilo
J
J
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D014009:Onychomycosis / Q000188:drug therapy*; D014508:Urea / Q000627:therapeutic use*
D000935:Antifungal Agents; D007093:Imidazoles; D009824:Ointments; D014508:Urea; C036596:bifonazole