recA and catalase in H2O2-mediated toxicity in Neisseria gonorrhoeae.
Neisseria gonorrhoeae cells defective in the biosynthesis of the recA gene product are no more sensitive to hydrogen peroxide than wild-type cells. Although gonococci possess nearly 100-fold-greater catalase levels than Escherichia coli, they are more susceptible to hydrogen peroxide than this organism. The natural niche of gonococci undoubtedly results in exposure to oxidant stress; however, they do not demonstrate particularly efficient antioxidant defense systems.
Hassett
D J
DJ
Department of Medicine, University of North Carolina, Chapel Hill 27514.
Charniga
L
L
Cohen
M S
MS
D002374:Catalase / Q000502:physiology*; D004260:DNA Repair; D006861:Hydrogen Peroxide / Q000633:toxicity*; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D011938:Rec A Recombinases / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014466:Ultraviolet Rays
D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D011938:Rec A Recombinases