Plasma atrial natriuretic factor concentration in a heart-lung transplant recipient.
Plasma concentration of atrial natriuretic factor, a polypeptide secreted by the heart, was measured in a heart-lung transplant recipient before operation and for 8 days after operation, until the patient died. Plasma atrial natriuretic factor level decreased in combination with the transplantation; after transplantation the peptide level varied within a wide range, correlating with diastolic pulmonary artery pressure (r = 0.93, p less than 0.01). The physiologic atrial natriuretic factor response to changes in right ventricular afterload thus seems to be preserved in the denervated heart.
Hynynen
M
M
Department of Anesthesia, Helsinki University Central Hospital, Finland.
Harjula
A L
AL
Salmenperä
M
M
Tikkanen
I
I
Fyhrquist
F
F
Mattila
S
S
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D016041:Heart-Lung Transplantation; D006801:Humans; D008297:Male; D011669:Pulmonary Wedge Pressure; D011863:Radioimmunoassay
D009320:Atrial Natriuretic Factor