Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.
The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen phenotypes during the evolution of hypertensive hypertrophy. Therapy with captopril, an angiotensin-converting enzyme inhibitor that regresses cardiac hypertrophy, not only reduces the total amount of collagen but reverses the altered distribution of type I and type III collagen. In normotensive rats, captopril did not significantly reduce collagen content or alter the ratio of type I to type III collagen.
Mukherjee
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Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195-5071.
Sen
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D000367:Age Factors; D000818:Animals; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology*; D003094:Collagen / Q000032:analysis*; D003488:Cyanogen Bromide; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D010641:Phenotype; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D013053:Spectrophotometry
D003094:Collagen; D002216:Captopril; D003488:Cyanogen Bromide; D006909:Hydroxyproline