A study on opioid peptides in CSF of patients with epilepsy.
The contents of L-EK, M-EK and beta-EP in CSF of 32 epileptics and 24 controls were determined by RIA. The mean L-EK content of epileptics was significantly higher than that of the controls (P less than 0.01). There were no obvious changes with respect to mean M-EK and beta-EP contents. No significant differences were seen in L-EK contents between generalized and partial seizures, treated and untreated with antiepileptic drugs, normal and abnormal CT manifestation patient groups. These data indicated that endogenous L-EK content was related to human epilepsy, and changes in opioid peptides were selective changes shared by different types of seizures. The increase of L-EK content was not caused by taking antiepileptic drugs, nor due to structural pathological changes of the brain that might be found on CT scanning, but a manifestation of neurochemical disorders of the brain that resulted in epilepsy.
Cheng
J G
JG
Neurological Research Unit, Qingdao Medical College, Qingdao, Shandong, People's Republic of China.
Xie
X K
XK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D004743:Enkephalin, Leucine / Q000134:cerebrospinal fluid*; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid*; D004828:Epilepsies, Partial / Q000134:cerebrospinal fluid*; D004833:Epilepsy, Temporal Lobe / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012737:Sex Factors; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*
D002556:Cerebrospinal Fluid Proteins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D001615:beta-Endorphin