Influence of different types and levels of dietary lipids on liver microsomal mixed function oxidase system in rats.
It has been shown that dietary polyunsaturated fatty acids stimulate the liver microsomal mixed function oxidase system. The influence of different levels of dietary lard, soybean oil and sardine oil on the mixed function oxidase system was investigated in rats. The diet containing 5% sardine oil rich in eicosapentaenoic and docosahexaenoic acids stimulated the mixed function oxidase system, but the diet containing 5% lard in which lard consisted of 10.7% linolenic acid and 1.5% linolenic acid seemed unlikely to stimulate enough the mixed function oxidase system. On the other hand, no definite effects of large doses of dietary lipids, 25% in the diets, on the mixed function oxidase system were observed.
Saito
M
M
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan.
Kubota-Shirao
M
M
Kobatake
Y
Y
Yamaguchi
M
M
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005395:Fish Oils; D008042:Linolenic Acids / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep; D013024:Soybean Oil
D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D008042:Linolenic Acids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D013024:Soybean Oil; D015118:Eicosapentaenoic Acid; D006899:Mixed Function Oxygenases; D000633:Aminopyrine N-Demethylase; C029310:lard