Role of G-proteins in receptor signalling in T and B cells.
Guanine nucleotide regulatory (G) proteins control signalling via a variety of widely distributed cell surface receptors. Relatively little is known about the involvement of G-proteins in signal transduction via biologically important receptors on lymphocytes. This review focuses primarily on the role of G-proteins in controlling antigen receptor-stimulated inositol phospholipid hydrolysis in B and T cells. Surface Ig receptors are clearly typical G-protein linked receptors. In contrast, there is only suggestive, but not definitive evidence for G-protein participation in signal transduction via the T cell antigen receptors.
Klaus
G G
GG
Division of Immunology, National Institute for Medical Research, London, UK.
D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc / Q000502:physiology; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*
D000944:Antigens, Differentiation, B-Lymphocyte; D011948:Receptors, Antigen, T-Cell; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D019204:GTP-Binding Proteins