Hematoporphyrin diethers--V. Plasma protein binding and photosensitizing efficiency.
1. Binding of added hematoporphyrin (HP) ethers to human plasma proteins and lipoproteins has been investigated by ultracentrifugation. 2. The binding to low density lipoproteins (LDL) has been discussed in terms of photosensitized tumor growth delay of tumors and HPLC-retention time, i.e. degree of polarity. 3. The LDL-binding data show a uniform relationship to sensitizing efficiency and degree of polarity, the only exception being HP-diamyl ether. No such uniform relationship exists for less related dyes, such as HP, tetraphenylporphyrin tetrasulfonate and HP-dimethyl ether.
Kongshaug
M
M
Department of Biophysics, Norwegian Radium Hospital, Oslo.
Rimington
C
C
Evensen
J F
JF
Peng
Q
Q
Moan
J
J
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D017323:Dihematoporphyrin Ether; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D011838:Radiation-Sensitizing Agents / Q000378:metabolism* / Q000627:therapeutic use; D012709:Serum Albumin / Q000378:metabolism; D014461:Ultracentrifugation
D001798:Blood Proteins; D006415:Hematoporphyrins; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D011838:Radiation-Sensitizing Agents; D012709:Serum Albumin; C067528:hematoporphyrin dipentyl ether; D017323:Dihematoporphyrin Ether