title: Cadherin subclasses: differential expression and their roles in neural morphogenesis.
abstract: Cadherins homophilically bind cells. Thus, cells expressing identical cadherins adhere selectively to each other, and they do not randomly intermix with the cells expressing other types of cadherins in vitro. Neural tissues express multiple types of cadherins, and the expression of each cadherin type is spatiotemporally regulated within a tissue during development. This molecular family therefore could operate for the sorting of different cell types in the nervous system. The regulation of N-cadherin expression is also important for the early development of the neural tube. The ectopic expression of N-cadherin in Xenopus embryos, which was induced by mRNA injection, led to the disorganization of neural tube structures or the fusion of the neural tube to the epidermis. These results suggest that the precise regulation of cadherin expression at the quantitative as well as at the qualitative level si crucial for neural morphogenesis.
authors: Department of Biophysics, Faculty of Science, Kyoto University, Japan.
authors: M
authors: M
authors: Takeichi
authors: H
authors: H
authors: Inuzuka
authors: K
authors: K
authors: Shimamura
authors: T
authors: T
authors: Fujimori
authors: A
authors: A
authors: Nagafuchi
mesh_terms: D000818:Animals; D015820:Cadherins / Q000145:classification / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D002642:Chick Embryo; D009420:Nervous System / Q000166:cytology / Q000196:embryology*; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000166:cytology / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014982:Xenopus laevis
chemical_list: D015820:Cadherins; D012333:RNA, Messenger