Modification of transformation of C3H/10T1/2 cells by a differentiation-inducing substance.
Transformation of C3H/10T1/2 cells was induced by 3-methylcholanthrene. Treatment with hexamethylene bisacetamide (HMBA), a differentiation inducing and poly (ADP-ribose)-synthesis modifying substance, influences expression of multilayered foci in a treatment schedule-dependent manner. Inhibition of transformation occurred only if HMBA was present after the genotoxic damage. After HMBA treatment most of transformed cells showed an end-differentiation like form.
Schneider
M
M
Institute of Biology, Research Centre Seibersdorf, Austria.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002999:Clone Cells / Q000166:cytology / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D008748:Methylcholanthrene; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011519:Proto-Oncogenes / Q000187:drug effects
D000081:Acetamides; D008748:Methylcholanthrene; D011065:Poly(ADP-ribose) Polymerases; C014026:hexamethylene bisacetamide