High-performance liquid chromatography of the drug fosenopril.
High-performance liquid chromatography was used to determine the purity and impurities of fosinopril, an angiotensin-converting enzyme inhibitor used to treat hypertension. Purity values are determined using a silica column and usually are above 99%. All known possible impurities, including stereoisomeric impurities, can be resolved and quantified by injecting solutions of fosinopril onto three separate columns; silica, strong anion exchange and phenyl. Typical impurity contents total 0.5%. Validation data and a study of properties of fosinopril in solution is included.
Kirschbaum
J
J
Squibb Institute for Medical Research, New Brunswick, NJ 08903-0191.
Noroski
J
J
Cosey
A
A
Mayo
D
D
Adamovics
J
J
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D017328:Fosinopril; D011392:Proline / Q000031:analogs & derivatives* / Q000032:analysis
D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D017328:Fosinopril