Central serotonergic modulation of drinking behavior induced by water deprivation: effect of a serotonergic agonist (MK-212) administered intracerebroventricularly.
The present study was carried out to evaluate the participation of the serotonergic system (5-HT) in the modulation of the drinking response induced by water deprivation. Male Wistar rats implanted with a cannula in the 3rd ventricle were injected with the 5-HT1C/5-HT2 agonist 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) at doses of 0.5, 5, 25, 50 and 125 nmol/2 microliters. MK-212 induced a significant reduction (P less than or equal to 0.05) in water intake over a period of 300 min. This result indicates that the central 5-HT system plays an important role, probably at the level of the periventricular hypothalamus, in the modulation of drinking behavior induced by water deprivation.
Reis
L C
LC
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Ramalho
M J
MJ
Antunes-Rodrigues
J
J
D000818:Animals; D004327:Drinking Behavior / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D011719:Pyrazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis; D012701:Serotonin / Q000502:physiology*; D014868:Water Deprivation / Q000502:physiology*
D011719:Pyrazines; D011985:Receptors, Serotonin; D012701:Serotonin; C014896:6-chloro-2-(1-piperazinyl)pyrazine