[Malignant Neuroleptic Syndrome during tiapride treatment].
Tiapride, a benzamide compound, is a neuroleptic drug used in the treatment of some behavior troubles, especially in the alcohol withdrawal syndrome. We report a new case of malignant neuroleptic syndrome during a tiapride treatment in a 39 year-old alcoholic patient who had been admitted after a minor trauma. Symptoms were typical, with malignant hyperthermia in the absence of sepsis, coma, extrapyramidal syndrome, rhabdomyolysis, and severe metabolic acidosis. Dantrolene succeeded to reverse hyperthermia and rigidity; probably due to its delayed administration however, irreversible acidosis led to the patient's demise.
Tamion
F
F
Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Charles Nicolle, Rouen.
Petit
J
J
Massari
P
P
Leroy
J
J
Biga
N
N
Oksenhendler
G
G
D000328:Adult; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D013976:Tiapamil Hydrochloride / Q000009:adverse effects*
D013976:Tiapamil Hydrochloride
Syndrome malin des neuroleptiques au cours d'un traitement par le tiapride.