title: Scar carcinomas of the lung in a histoplasmosis endemic area.
abstract: Seventeen cases of pulmonary scar carcinomas were found in 112 surgically resected pulmonary carcinomas from 1985 through 1988 in a hospital situated in a histoplasmosis endemic area. These carcinomas can be divided into two types: Type I, mucinous; and Type II, non-mucinous (Clara cell). Each type of carcinoma constitutes a discrete group in reference to gross features, histologic and ultrastructural cell types, and the nature of the scar. The scar in Type I carcinomas appears mostly desmoplastic. The majority of Type II carcinomas appear to have arisen around a preexisting histoplasmosis granuloma which contains yeast organisms on microscopic examination. Pulmonary scar carcinoma is not a single discrete clinicopathologic entity. It appears that peripheral carcinomas of different histogenesis are incorporated in this category.
authors: Department of Pathology, Veterans Administration Medical Center, Lexington, Kentucky 40511.
authors: K
authors: K
authors: Yoneda
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000209:etiology / Q000473:pathology / Q000648:ultrastructure; D002277:Carcinoma / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure; D002921:Cicatrix / Q000150:complications*; D003094:Collagen / Q000032:analysis; D006660:Histoplasmosis / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure; D008198:Lymph Nodes / Q000473:pathology
chemical_list: D003094:Collagen