Acetate or bicarbonate for haemodialysis: a randomised, double-blind controlled trial.
In a prospective, randomised, double blind controlled trial the adverse reactions, food consumption, changes in blood chemistry including acid-base balance, and anthropometry were studied during two consecutive dialysis periods of 3 months, using either acetate- or bicarbonate-based dialysis fluids. Sixteen chronic, stable patients were included. The dialysis fluid sodium content was fixed at 140 mmol/l during all treatments. Patient complaints and adverse reactions were identical using the two dialysis fluids. No differences were observed regarding blood chemistry except for a less pronounced metabolic acidosis present during bicarbonate dialysis compared to acetate dialysis. A slight but insignificant increment in food consumption and nutritional status was noticed during bicarbonate dialysis. In conclusion, the use of a bicarbonate-based haemodialysis fluid offered no significant advantages compared to an acetate-based one in the haemodialysis of chronic, stable patients.
Otte
K E
KE
Department of Nephrology, Odense University Hospital, Denmark.
Lillevang
S T
ST
Rasmussen
A G
AG
Christensen
H K
HK
Pedersen
F B
FB
D000085:Acetates; D000328:Adult; D000368:Aged; D001639:Bicarbonates; D001835:Body Weight; D015314:Dialysis Solutions; D004311:Double-Blind Method; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis
D000085:Acetates; D001639:Bicarbonates; D015314:Dialysis Solutions