[What plays an important role in the secretion of alpha-human atrial natriuretic polypeptide (alpha-hANP) during the early stage of acute myocardial infarction?].
To clarify the factors stimulating the secretion of alpha-human atrial natriuretic polypeptide (alpha-hANP) during the early stage of acute myocardial infarction (AMI), the plasma alpha-hANP level was sequentially measured and evaluated in terms of correlation with the severity of AMI, cardiovascular hemodynamics and endocrine functions in 61 patients with AMI. The plasma alpha-hANP levels within 24 hrs, from 48 to 72 hrs, and from 120 to 168 hrs after the onset of AMI were 213.8 +/- 198.0, 152.0 +/- 131.2, and 156.0 +/- 166.4 pg/ml, respectively, all of which were significantly higher compared to the control level (29.6 +/- 9.3 pg/ml). In surviving patients, the level of plasma alpha-hANP within 24 hrs was significantly higher than those in 48-72 and 120-168 hrs. On the contrary, non-surviving patients displayed prolonged elevation of alpha-hANP during the early stage of AMI. The initial alpha-hANP levels in Killip I, II, III and IV patients were 229.3 +/- 232.7 (n = 43), 216.7 +/- 86.6 (n = 7), 243.3 +/- 113.5 (n = 6) and 282.0 +/- 224.6 pg/ml (n = 5), respectively, and there were no significant differences between the categories.(ABSTRACT TRUNCATED AT 250 WORDS)
Shimai
S I
SI
Department of Internal Medicine, Nippon Medical School, Tokyo.
Takano
T
T
Kiuchi
K
K
Ibuki
C
C
Takada
K
K
Seino
Y
Y
Tanaka
K
K
Katoh
T
T
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D012044:Regression Analysis; D013961:Thyroid Gland / Q000503:physiopathology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D009320:Atrial Natriuretic Factor; D013974:Thyroxine