[Effect of verapamil on rate of restenosis following transluminal angioplasty of renal artery stenoses].
This prospective double-blind randomized study examined the effect of verapamil on restenosis after angioplasty of renal artery stenoses. 31 patients received placebo or 120 mg verapamil two or three times daily until the appointed day of the control angiography after 3 months. All patients received 1.5 g aspirin per day. In the control group (13 stenoses, 12 patients) the degree of stenoses increased from 35 +/- 15% immediately after PTA to 41 +/- 21% at repeat angiography 3 months after PTA, in the verapamil group (20 stenoses, 14 patients) from 35 +/- 16% to 43 +/- 22% (ns). Stenoses recurred in 23% of the stenoses in the placebo group and in 20% of the stenoses in the verapamil group (ns). 5 patients, who interrupted the therapy, were excluded from the evaluation. In the conclusion, verapamil does not decrease the incidence of restenosis after PTA of renal artery stenoses during concurrent therapy with aspirin.
Schmidt
E
E
Abteilung für Kardiologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt.
Grützmacher
P
P
Meyer
T
T
Kaltenbach
M
M
Schoeppe
W
W
Bussmann
W D
WD
D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012008:Recurrence; D012077:Renal Artery / Q000000981:diagnostic imaging; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000628:therapy*; D014700:Verapamil / Q000008:administration & dosage*
D014700:Verapamil
Einfluss von Verapamil auf die Restenosierungsrate nach transluminaler Angioplastie von Nierenarterienstenosen.