[Radiosensitization of Lewis lung tumor by perfluorochemical emulsion comparison between single and fractionated irradiation].
Previously perfluorochemical emulsion (FDAS) was shown to enhance tumor growth delay, when applied together with breathing carbogen (95% O2+5% CO2) before and during irradiation. In the present paper, radiosensitizing effects of FDAS in tumor bearing mice were examined on a single (10 Gy) and fractionated irradiation (4 Gy, 4 times) and on the dose of administration. The results were as follows; 1) All groups of single irradiation with injection of FDAS 10-40 ml/kg could enhance the radiosensitivity of LLC bearing mice. 2) Tumor growth of even fractionated irradiation groups was significantly delayed by administration of FDAS more than 5 ml/kg. 3) In case of fractionated irradiation, the minimum effective dose of FDAS was estimated to be 5 ml/kg per irradiation, which coincided with that of single irradiation. It was concluded that FDAS in fractionated irradiation could increase the radiosensitivity in tumor bearing mice with more than 5 ml/kg injection. Therefore, FDAS may be useful as a radiosensitizer for clinical application in fractionated radiation therapy. Furthermore, since irradiation doses of single (10 Gy) and even fractionated irradiation (4 Gy X 4 times) were approximately iso effective dose, it may be considered that administration of more than 5 ml/kg (minimum effective dose) FDAS at each irradiation gave similar radiosensitizing effects to both single and fractionated irradiation.
Hishikawa-itoh
Y
Y
Department of Radiology, Aichi Medical University.
Miyata
N
N
D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000532:radiotherapy*; D051379:Mice; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011879:Radiotherapy Dosage
D004655:Emulsions; D005466:Fluorocarbons; D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen