[The study of resorcin eyedrops].
Seven resorcin eye drop formulas using various physico-chemical stabilizers, acid buffer solutions, antioxidants such as sodium pyrosulphite, cysteine and keodants such as EDTA--Na were prepared. A parallelism between the physico-chemical stability and local biological tolerance in rabbit eyes was found, fact demonstrating that the occurrence of some oxidation products are responsible for the biological intolerance manifestations. A pH under 5 is favourable to resorcin stability and local biological tolerance to resorcin eye drops.
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Facultatea de farmacie, Iaşi.
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D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003228:Conjunctiva / Q000187:drug effects; D004361:Drug Tolerance; D006863:Hydrogen-Ion Concentration; D009883:Ophthalmic Solutions; D011817:Rabbits; D012118:Resorcinols / Q000737:chemistry* / Q000494:pharmacology; D013997:Time Factors
D009883:Ophthalmic Solutions; D012118:Resorcinols; C031389:resorcinol
Contribuţii la studiul picăturilor pentru ochi cu rezorcină.