Dual species dependent effect of dihydroergosine on the convulsions induced by GABA antagonists.
The potential antidepressant dihydroergosine enhanced the convulsive properties of picrotoxin and bicuculline in rats and diminished them in mice. The possibility of dihydroergosine modulating species-dependently GABA/benzodiazepine receptors is suggested.
Pericić
D
D
Department of Experimental Biology and Medicine, Rudjer Bosković Institute, Zagreb, Yugoslavia.
Manev
H
H
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001640:Bicuculline; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004879:Ergotamines / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010852:Picrotoxin; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D013045:Species Specificity
D000928:Antidepressive Agents; D001640:Bicuculline; D004879:Ergotamines; D010852:Picrotoxin; D011963:Receptors, GABA-A; C037580:9,10-dihydroergosine