HIV excretion patterns and specific antibody responses in body fluids.
HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti-nef, and anti-p24. Viral load in peripheral blood appeared to increase with disease progression. The proportion of patients with antibody responses specific for nef and p24 was also lower among patients with more advanced disease. Infectious virus and viral antigens were detected infrequently and at lower levels in body fluids than in blood, which may reflect the presence of local antibodies. HIV nucleic acid was detected in some semen and saliva samples in the absence of infectious virus.
O'Shea
S
S
Department of Virology, United Medical School, Guys Hospital, London.
Cordery
M
M
Barrett
W Y
WY
Richman
D D
DD
Bradbeer
C
C
Banatvala
J E
JE
D005260:Female; D015683:Gene Products, gag / Q000276:immunology; D015693:Gene Products, nef / Q000276:immunology; D005836:Genitalia, Female / Q000276:immunology* / Q000382:microbiology; D006678:HIV / Q000276:immunology / Q000302:isolation & purification; D015483:HIV Antibodies / Q000096:biosynthesis*; D015488:HIV Antigens / Q000032:analysis; D016655:HIV Core Protein p24; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D012463:Saliva / Q000276:immunology* / Q000382:microbiology; D012661:Semen / Q000276:immunology* / Q000382:microbiology; D014758:Viral Core Proteins / Q000276:immunology; D054311:nef Gene Products, Human Immunodeficiency Virus
D015683:Gene Products, gag; D015693:Gene Products, nef; D015483:HIV Antibodies; D015488:HIV Antigens; D016655:HIV Core Protein p24; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014758:Viral Core Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus