In vitro antimicrobial activity of a novel aminothiazolylglycylcephalosporin, MT0703S, compared with that of ceftazidime, cefoperazone and aztreonam.
The antibacterial activity of a novel aminothiazolylglycylcephalosporin, MT0703S, possessing a dihydroxypyridone moiety was compared in vitro with the activity of ceftazidime, cefoperazone, aztreonam and other beta-lactam antibiotics using seven bacterial species of a clinical origin. MT0703S showed the most potent activity against P. aeruginosa, including the ceftazidime-resistant strains, E. coli, K. pneumoniae and C. freundii. MT0703S was comparable to aztreonam but more active than ceftazidime and cefoperazone in its activity against K. oxytoca and E. cloacae, and comparable to ceftazidime against S. aureus and S. marcescens. MT0703S was more active than cefoperazone against S. marcescens but less active against S. aureus. The stability of MT0703S against various beta-lactamases appeared to be intermediate between the stability of ceftazidime and that of cefoperazone. The antimicrobial activity of MT0703S increased in a low-iron environment and decreased in a high ferric ion concentration.
Okamoto
R
R
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Hara
T
T
Yoshida
T
T
Orikasa
Y
Y
Ogino
H
H
Iwamatsu
K
K
Inouye
S
S
D001398:Aztreonam / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D007501:Iron / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis
D002511:Cephalosporins; C063437:MT 0703; D002438:Cefoperazone; D002442:Ceftazidime; D007501:Iron; D001618:beta-Lactamases; D001398:Aztreonam