Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli.
It was speculated that the increase of the UDP-GlcNAc pool observed with chloramphenicol can modulate the residual PEP:UDP-GlcNAc-enolpyruvate activity of fosfomycin-treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP-MurNAc-pentapeptide to sustain peptidoglycan synthesis at a rate that will antagonize fosfomycin-induced lysis.
Mengin-Lecreulx
D
D
Unité Associée du CNRS, Biochimie Moléculaire et Cellulaire, Université Paris-Sud, Orsay, France.
van Heijenoort
J
J
D001433:Bacteriolysis / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005578:Fosfomycin / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D017351:N-Acetylglucosaminyltransferases; D009711:Nucleotides / Q000096:biosynthesis; D010457:Peptidoglycan / Q000096:biosynthesis
D009711:Nucleotides; D010457:Peptidoglycan; D005578:Fosfomycin; D002701:Chloramphenicol; D005964:Glucosyltransferases; D017351:N-Acetylglucosaminyltransferases; C038276:PEP-UDP-GlcNAc transferase