[Neopterin determination in the screening for spongiosa donors].
HIV-1 and HIV-2 antibodies, erythrocyte sedimentation rate, leucocytes and additionally serum neopterin levels were measured in 100 potential spongiosa donors. HIV antibodies were negative in all patients, whereas in 24% neopterin levels were elevated (greater than 10 nmol/l). Enhanced neopterin production is related to activity in cell-mediated immune response. In further investigations of these patients we found in 29% infections, 38% tumor diseases and 13% autoimmune diseases, all being exclusion criteria for spongiosa transplantation. In 3 patients increased neopterin values were the only pathological screening parameters. The measurement of serum neopterin levels showed to be a helpful parameter for the selection of spongiosa donors.
Peters
K M
KM
Orthopädische Klinik, Medizinischen Fakultät, RWTH Aachen.
Leusch
H G
HG
Bruchhausen
B
B
Schilgen
M
M
Markos-Pusztai
S
S
D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood; D016025:Bone Transplantation; D005260:Female; D006801:Humans; D007239:Infections / Q000097:blood; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D014019:Tissue Donors
D015415:Biomarkers; D001708:Biopterins; D019798:Neopterin
Neopterinbestimmungen zum Screening von Spongiosaspendern.