title: Short-term intrathrombotic injection of ultrahigh-dose urokinase for treatment of iliac and femoropopliteal artery occlusions.
abstract: Thirty-two patients with iliac and femoropopliteal artery occlusions were treated with direct intrathrombotic injection of ultrahigh-dose urokinase (10,000 IU/min). Occlusions ranged from 3 to 25 cm (average 13.3 cm) in length and the total urokinase dose from 120,000 to 1,410,000 IU (average 688,000 IU). The procedure was usually followed by balloon angioplasty to dilate the underlying stenoses. The initial recanalization rate was 96.9%, the two week patency rate 81.3%, and the cumulative one-year patency rate 66.3%. Complications associated with this procedure included three episodes of minimal bleeding, two distal embolisms, one local hematoma, and one low-grade fever. All were well controlled by palliative treatment. Results indicate that this procedure can provide rapid recanalization at a higher success rate and with fewer complications than previously reported.
authors: Department of Radiology, Wakayama Medical College, Japan.
authors: M
authors: M
authors: Terada
authors: M
authors: M
authors: Satoh
authors: K
authors: K
authors: Mitsuzane
authors: Y
authors: Y
authors: Shioyoyama
authors: M
authors: M
authors: Tsuda
authors: K
authors: K
authors: Kishi
authors: M
authors: M
authors: Maeda
authors: S
authors: S
authors: Momura
authors: R
authors: R
authors: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D015901:Angiography, Digital Subtraction; D000800:Angioplasty, Balloon; D003131:Combined Modality Therapy; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000000981:diagnostic imaging; D012008:Recurrence; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D015912:Thrombolytic Therapy / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage* / Q000627:therapeutic use; D014654:Vascular Patency
chemical_list: D014568:Urokinase-Type Plasminogen Activator