[Good tolerance and absence of immunologic effects in mice treated with arsenic-rich thermal water].
Three strains of mice were given, per os and ad libitum, a spa water containing 6.8 mg/l arsenic and indicated for the treatment of allergic respiratory diseases or chronic bronchitis. The daily arsenic intake was approximately from 1.5 to 4 mg/kg. No effect on body weight gain or on the various immune parameters assessed was observed. These results demonstrate that this spa water, despite its high arsenic content, is not toxic and does not interfere with the immune system of healthy mice.
Mercier
P
P
Département de Pharmacologie Clinique, INSERM U13, Paris.
Papon
E
E
Van Den Berghe
C
C
Drutel
P
P
Rouveix
B
B
D000818:Animals; D001151:Arsenic / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D004361:Drug Tolerance; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008900:Mineral Waters / Q000032:analysis*
D008900:Mineral Waters; D001151:Arsenic
Bonne tolérance et absence d'effets immunologiques chez la souris traitée par une eau thermale riche en arsenic.