title: Prostacyclin production by blood-contacting surfaces of endothelialized vascular prostheses.
abstract: This study examines prostacyclin production by blood-contacting surfaces within woven vascular prostheses of polydioxanone (PDS), polyglactin 910 (PG910), or Dacron interposed into rabbit infrarenal aortas. Grafts and normal aortic segments were explanted after 1, 3, and 6 months for pulsatile perfusion with Medium-199 for 60 minutes. Aliquots were removed serially for 6-keto-PGF1 alpha assay. After 30 minutes sodium arachidonate (10 micrograms/ml) was added. Specimens were studied by light microscopy, SEM and TEM. Patency in all three groups exceeded 90%. All three showed re-endothelialization at one month. Normal aorta produced low basal 6-keto-PGF1 alpha with a marked evanescent post arachidonate increase. Dacron did not differ from normal aorta. PG910 and PDS both produced significantly less 6-keto-PGF1 alpha post arachidonate at one month but both increased to normal by three months.
authors: Loyola University Medical Center, Maywood, IL.
authors: H P
authors: HP
authors: Greisler
authors: J J
authors: JJ
authors: Klosak
authors: J F
authors: JF
authors: McGurrin
authors: E D
authors: ED
authors: Endean
authors: J
authors: J
authors: Ellinger
authors: J D
authors: JD
authors: Pozar
authors: S C
authors: SC
authors: Henderson
authors: D U
authors: DU
authors: Kim
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D001012:Aorta, Abdominal; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D016687:Polydioxanone; D011091:Polyesters; D011093:Polyethylene Terephthalates; D011098:Polyglactin 910; D011817:Rabbits; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011093:Polyethylene Terephthalates; D016687:Polydioxanone; D011098:Polyglactin 910; D015121:6-Ketoprostaglandin F1 alpha