[Plasma concentration of atrial natriuretic peptide, vasopressin and aldosterone in the umbilical cord blood: its relation to perinatal asphyxia].
Aldosterone, vasopressin (AVP) and atrial natriuretic factor (ANF) plasmatic concentrations were determined in cord arterial blood from 42 newborns to term: 29 healthful and 13 with perinatal asphyxia. Control group showed plasmatic levels (pg/dl) AVP, aldosterone and ANF significantly lower than perinatal asphyxia newborns group (AVP: 2.27 +/- 1.43 vs 4.26 +/- 2.86; aldosterone: 1.113 +/- 384.79 vs 1,540.38 +/- 595.96; ANF: 2.27 +/- 1.43 vs 4.26 +/- 2.86, respectively (p less than 0.05). We found an inverse correlation between umbilical arterial pH vs AVP, aldosterone and AFN, and a direct correlation between ANF vs aldosterone. Perinatal asphyxia induces secretion of the three studied hormonal factors, likely as a physiologic mechanism of fetal adaptation to hydroelectrolytic and hemodynamic changes which occur during the asphyxia.
Narbona López
E
E
Departamento de Pediatría, Hospital Universitario, Facultad de Medicina, Universidad de Granada.
Maldonado Lozano
J
J
Nieto García
M
M
García del Río
C
C
Loscertales Abril
M
M
D000450:Aldosterone / Q000097:blood*; D001238:Asphyxia Neonatorum / Q000097:blood*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor
Concentraciones plasmáticas de péptido natriurético atrial, vasopresina y aldosterona en sangre de cordón umbilical: sus relaciones con la asfixia perinatal.