Involvement of lipoproteins in suppression of interleukin 2-dependent cell proliferation by sera from aged humans.
Sera from the elderly, but not young, inhibited markedly interleukin 2 (IL-2)-dependent proliferation of cloned T cells. Sera of aged humans contained high levels of triglyceride, cholesterol, very low density lipoproteins (VLDL) and low density lipoproteins (LDL). VLDL and LDL inhibited the proliferation in a dose-related manner. The inhibition correlated with levels of serum VLDL and LDL. These results suggest that lipoproteins may act as a regulator of IL-2-dependent proliferation and that disturbance of lipid and lipoprotein metabolism may be partially responsible for diminished immune responses in the elderly.
Ohtsuka
Y
Y
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Kobayashi
K
K
Hirano
T
T
Furukawa
S
S
Nagano
S
S
Takahashi
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D001053:Apolipoproteins / Q000097:blood / Q000276:immunology / Q000494:pharmacology; D002460:Cell Line; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D008055:Lipids / Q000097:blood / Q000276:immunology / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood / Q000276:immunology / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000097:blood / Q000276:immunology / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects*
D001053:Apolipoproteins; D007376:Interleukin-2; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL