Vaccine failure in malnourished animals: use of a bioimmunomodulator to improve immunocompetence.
Vaccine failure attributable to immunodeficiency is common in stressed individuals. During vitamin-B complex and ascorbic acid malnutrition in experimental animals, vaccine failure is accounted for by the atrophy of the immunocompetent organs. In an attempt to improve immunocompetence, a bioimmunomodulator obtained from the supernatant fluid from cultured normal bone-marrow cells was injected following immunization into young animals receiving a diet deficient in vitamins B and C. This treatment improved the immunosurveillence of mice and rats approximately 3 to 4 fold. Peculiarly, this factor failed to evoke immunostimulation in normal immunized animals, probably because of a suppressing mechanism.
Ghoshal
D
D
Department of Chemistry, Bose Institute, Calcutta, India.
Barua
A K
AK
Roy
S K
SK
Bhattacharrya
H
H
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000302:isolation & purification; D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007121:Immunocompetence; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009748:Nutrition Disorders / Q000276:immunology*; D051381:Rats; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D014612:Vaccines