GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Histological examination demonstrated marked neuronal damage to hippocampal neurons. However, in the same region, GAD-IR neurons were preserved. The present data demonstrate a selective resistance of GABAergic neurons to status epilepticus-induced neuronal damage, suggesting that loss of hippocampal GABAergic neurons does not underlie the recurrence of seizures in these animals.
Cavalheiro
E A
EA
Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, São Paulo, Brasil.
D000818:Animals; D004828:Epilepsies, Partial / Q000473:pathology; D005968:Glutamate Decarboxylase / Q000032:analysis*; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology*; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012008:Recurrence; D012640:Seizures / Q000209:etiology*; D013226:Status Epilepticus / Q000139:chemically induced / Q000473:pathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D010862:Pilocarpine; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase