Left ventricular diastolic function in normotensive adolescents with different genetic risk of hypertension.
Abnormalities of the diastolic function of the left ventricle are the first sign of cardiac involvement in arterial hypertension. We have studied the diastolic function in a group of normotensive adolescents with confirmed family history of hypertension. M-mode echocardiography was performed in 86 normotensive males aged 14-19 years: 41 sons of at least one hypertensive parent (SHT) and 45 sons of normotensive parents (SNT). Cross-sectional area of the left ventricle and left ventricular (LV) mass index were significantly greater in the SHT than in the SNT group (10.05 +/- 1.84 vs. 8.9 +/- 1.56 cm/m2, p less than 0.01 and 129.3 +/- 296.3 vs. 109.23 +/- 25.7 g/m2, p less than 0.002, respectively). No significant difference between the two groups was observed in the indices of left ventricular diastolic function, except for mitral valve opening rate (463.51 +/- 90.45 in SHT vs. 416.71 +/- 78.84 mm/s in SNT; p less than 0.02). From the analysis of the subgroup of adolescents having left ventricular mass greater than the upper normal value, we observed that they showed mean time of rapid filling significantly longer than SNT: this could represent an early marker of the pathological character of such hypertrophy. Our results suggest that the higher LV mass observed in the SHT is not associated with chamber and myocardial stiffness abnormalities.
Alli
C
C
Semeiotica Medica, University of Milan, Italy.
Avanzini
F
F
DiTullio
M
M
Mariotti
G
G
Salmoirago
E
E
Taioli
E
E
Radice
M
M
D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology*; D002306:Cardiac Volume / Q000502:physiology; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology; D003971:Diastole / Q000502:physiology*; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D012307:Risk Factors