Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.
Issemann
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Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.
Green
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000494:pharmacology*; D008099:Liver / Q000648:ultrastructure*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D008830:Microbodies / Q000187:drug effects* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D009255:Nafenopin / Q000494:pharmacology; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism; D011987:Receptors, Steroid / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution
D000960:Hypolipidemic Agents; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D009255:Nafenopin; D004247:DNA