[Loratadine and dexchlorpheniramine in the treatment of perennial allergic rhinitis in pediatric patients].
The use of loratadine was compared to dexchlorpheniramine in the treatment of children affected by perennial allergic rhinitis in order to assess its clinical efficacy and tolerability. Children were randomly assigned to two groups: 15 were treated with loratadine and 16 with dexchlorpheniramine. Loratadine was administered in a single daily dose of 5 mg (2.5 mg for children under 20 kg) and dexchlorpheniramine at a dose of 1 mg every 8 hours (0.5 mg for the youngest children). Clinical symptoms were recorded before and during the study using a score of 0.3 (from absent to severe). Symptoms were markedly reduced by both drugs. Eye burning was reduced more by loratadine (p less than 0.05) than the control drug. Rhinoscopic investigations revealed that both groups reacted favourably to the drugs used. Overall clinical assessment showed similar and revealed the good efficacy of both drugs. Tolerability was satisfactory and there were no signs of drowsiness. Hematological and hematochemical parameters showed no clinically significant changes and body weight remained constant. On the basis of these results, loratadine is preferable to dexchlorpheniramine thanks to its once-a-day dosing.
Longo
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G
Clinica Pediatrica, Ospedale Infantile Burlo Garofolo, Università di Trieste.
Poli
F
F
Ventura
A
A
Marchesi
E
E
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000627:therapeutic use*; D003533:Cyproheptadine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D017336:Loratadine; D008297:Male; D016032:Randomized Controlled Trials as Topic; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013237:Stereoisomerism
D006633:Histamine Antagonists; D003533:Cyproheptadine; C018904:dexchlorpheniramine; D002744:Chlorpheniramine; D017336:Loratadine
Loratadina e desclorfeniramina nel trattamento della rinite allergica perenne in pazienti pediatrici.