title: Angioplasty for long-term treatment of patients with Budd-Chiari syndrome.
abstract: The goal of radiologic intervention in patients with Budd-Chiari syndrome is to control portal hypertension and prevent further hepatocellular damage until collateral hepatic venous outflow channels can develop. Percutaneous balloon angioplasty was used to treat six patients with this syndrome who were followed up for an average of 43 months (range, 12-92 months). Standard interventional radiologic techniques were used to dilate the hepatic veins (two patients), inferior vena cava (three patients), and proximal anastomosis of a mesoatrial shunt (one patient). Angioplasty was the only invasive treatment in three patients, whereas the remaining three patients had previous portosystemic shunts. Clinical and hemodynamic improvement occurred after each angioplasty. Multiple dilatations were required in all patients (average, 3.2; range, 2-5) because of restenosis at the angioplasty site and ongoing hepatocyte necrosis shown by biopsy. Long-term benefit occurred in five patients despite ultimate caval occlusion in two patients and restenosis in one patient. One patient who was almost free of symptoms for 36 months developed gastrointestinal bleeding caused by portal hypertension. This experience suggests that balloon angioplasty is a safe and effective treatment for patients with Budd-Chiari syndrome. The therapy is not definitive, but serves to moderate the severity of the disease until collateral venous pathways develop. Multiple angioplasties are required for the long-term care of these patients.
authors: Department of Radiology, Emory University Hospital, Atlanta, GA 30322.
authors: L G
authors: LG
authors: Martin
authors: J M
authors: JM
authors: Henderson
authors: W J
authors: WJ
authors: Millikan
authors: W J
authors: WJ
authors: Casarella
authors: S L
authors: SL
authors: Kaufman
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D006502:Budd-Chiari Syndrome / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D003251:Constriction, Pathologic; D005260:Female; D006503:Hepatic Veins / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging / Q000473:pathology