Therapy of infections related to intraperitoneal catheters in patients with ovarian cancer.
Bacterial peritonitis is a common complication associated with catheters implanted for intraperitoneal anticancer chemotherapy in patients with extensive ovarian carcinoma. During an ongoing trial of intraperitoneal cisplatin-melphalan vs. cisplatin-gamma interferon, given via an intraperitoneal 'Port-a-cath' catheter, 6 episodes of suspected bacterial peritonitis occurred in 5 patients. Clinical symptoms were present in all episodes and 3 episodes were documented microbiologically. Teicoplanin was given intraperitoneally, 400 mg three times a day on the first day and once daily thereafter. Serum and peritoneal concentrations were measured by bioassay. Despite clinical improvement during therapy, the catheter was removed in 4 out of 5 patients after the end of intraperitoneal teicoplanin, due to the presence of infection. Additional patients are required to evaluate the efficacy of intraperitoneal teicoplanin in the treatment of catheter-related peritonitis associated with anticancer intraperitoneal chemotherapy.
Meunier
F
F
Service de Médecine Interne, Institut J. Bordet, Brussels, Belgium.
van der Auwera
P
P
Aoun
M
M
Piccart
M
M
Sculier
J P
JP
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002408:Catheters, Indwelling; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy*; D010537:Peritoneum; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D017334:Teicoplanin
D006020:Glycopeptides; D017334:Teicoplanin