Dipyridamole specifically decreases platelet-derived growth factor release from platelets.
The authors have previously reported that dipyridamole decreased platelet-derived growth factor levels in human serum by lowering the release of this factor during blood clotting. In the present study, we have shown that this effect is specific to dipyridamole, and does not occur with other antiplatelet drugs such as aspirin, trapidil or ticlopidine. In addition, dipyridamole has been shown to decrease the PDGF level selectively, but not the levels of other factors from alpha granules in platelets (beta-thromboglobulin and platelet factor 4). These data indicate that dipyridamole may be an effective drug for the prevention of PDGF-related disorders.
Takehara
K
K
Department of Dermatology, University of Tokyo Branch Hospital, Japan.
Igarashi
A
A
Ishibashi
Y
Y
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D004176:Dipyridamole / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008934:Mitogens / Q000494:pharmacology; D010978:Platelet Factor 4 / Q000187:drug effects; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D001620:beta-Thromboglobulin / Q000187:drug effects
D008934:Mitogens; D010982:Platelet-Derived Growth Factor; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D004176:Dipyridamole