[Studies on HLA-B27 and T-cell subsets in patients with endogenous anterior uveitis].
37 (37%) of 100 patients with anterior uveitis were found HLA-B27 positive (5.3% in the normal controls); 35 (94.6%) of the 37 cases were nongranulomatous and 78.0% were associated with various types of arthritis. T-cell subsets in periphery circulation were evaluated in 47 anterior uveitis patients and 18 controls by means of monoclonal antibodies. Patients with active anterior uveitis had less OKT3+ cells than patients in the inactive phase; there were more OKT4+ and OKT8+ cells in patients in the active phase than in the controls, and particularly the OKT8+ cells were more than in patients of the inactive phase. The mean OKT4+/OKT8+ ratio was not significantly different from that of the controls; however, values of the OKT4+/OKT8+ ratio were abnormal in some patients, and there were more cases with lower ratio values in the active than in the inactive patients.
Sun
S M
SM
Department of Ophthalmology, First Hospital, Beijing Medical University.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014606:Uveitis, Anterior / Q000209:etiology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015796:HLA-B27 Antigen