Strategies to promote regeneration and recovery in the injured spinal cord.
The damaged spinal cord has only a limited capacity for anatomical and functional recovery. However, a growing body of experimental work is demonstrating a potential for enhanced axonal regeneration and recovery following injury. Important pathophysiologic processes are discussed, along with strategies designed to improve outcome through the reconstruction of damaged pathways and the modulation of the spinal cord's response to the primary injury.
Kliot
M
M
Department of Neurosurgery, University of Washington, Seattle.
Lustgarten
J H
JH
D000818:Animals; D001369:Axons / Q000502:physiology; D002921:Cicatrix / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D013116:Spinal Cord / Q000098:blood supply / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation