[Kinetics of jejunal glucose transport in niacin deficient rats].
The kinetic of jejunal glucose transport was studied using perfused rat jejunum in vivo. Ninety rats were fed a diet deficient in niacin and 90 a control diet. The jejunal loops of 7 groups of animal were infused each group with one of following solutions of glucose: 5, 10, 20, 40, 80, 160 and 300 mM/l. The Vmax and Km values were determined. The results showed that the vitamin-deficient rats absorbed less glucose independently of the amount infused and these animals had lower Vmax (133.7 microM/15 min/15 cm) and Km (192.1 mM/l) than control groups (294.1 microM/15 min/15 cm and 171.8 mM/l, respectively). In conclusion one can assume that niacin deficiency leads to a decreased glucose absorption in the jejunal loops, when tested as in our experimental model.
Victoria
C R
CR
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista--UNESP, SP.
Meneghelli
U G
UG
D000818:Animals; D005947:Glucose / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D009525:Niacin / Q000172:deficiency*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D009525:Niacin; D005947:Glucose
Cinética do transporte jejunal de glicose em ratos com deficiência de niacina.