title: Propofol and alfentanil anesthesia during one-lung ventilation.
abstract: A total intravenous anesthesia technique, using a combination of propofol, alfentanil, and ventilation with 100% oxygen, was studied in a group of 14 patients scheduled for a lobectomy or pneumonectomy. Alfentanil was given at a constant rate, and propofol was administered to adjust the depth of anesthesia. The technique provided an effective and easily controllable anesthetic. Systolic and diastolic blood pressures and pulse rates remained stable throughout the procedure, including during one-lung ventilation. After induction, the mean blood pressure decreased 25% for a short period of time. Blood gas values and oxygen saturation remained satisfactory during the entire procedure. Recovery characteristics were good. Calculations of the shunt fraction showed a smaller increase during one-lung ventilation than expected.
authors: Department of Anaesthesiology, University of Stellenbosch Medical School, Tygerberg, Republic of South Africa.
authors: P A
authors: PA
authors: Steegers
authors: P J
authors: PJ
authors: Backx
mesh_terms: D015760:Alfentanil / Q000008:administration & dosage / Q000494:pharmacology; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D011013:Pneumonectomy; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D001261:Pulmonary Atelectasis / Q000503:physiopathology; D011674:Pulse / Q000187:drug effects; D012121:Respiration, Artificial / Q000379:methods*; D013997:Time Factors
chemical_list: D015760:Alfentanil; D010100:Oxygen; D015742:Propofol