title: Isolated dehydroepiandrosterone sulphate hypersecretion: a case report.
abstract: The case of a 17-year-old male with isolated hypersecretion of dehydroepiandrosterone sulphate (DHEAS) is described. Cushing syndrome, congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency, an androgen producing adrenal tumour, and elevated plasma DHEAS due to an increased renal threshold were excluded. Selective renal vein catheterization confirmed bilateral, isolated adrenal DHEAS hypersecretion. The dexamethasone suppression suggests a functional nature of this alteration. This condition has to be considered in the differential diagnosis of excessive adrenal androgen production in males, or of hirsutism in females.
authors: Department of Paediatrics, General Hospital of Bolzano, Italy.
authors: G
authors: G
authors: Radetti
authors: E
authors: E
authors: Cacciari
authors: M
authors: M
authors: Zachmann
mesh_terms: D000293:Adolescent; D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism*; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006628:Hirsutism / Q000175:diagnosis; D006801:Humans; D008297:Male
chemical_list: D003687:Dehydroepiandrosterone; D003907:Dexamethasone