Effect of chronic ivermectin treatment on GABA receptor function in ethanol withdrawal-seizure prone and resistant mice.
Ivermectin, a potent, effective anthelmintic, is easy to administer, has a broad spectrum of action and a wide safety margin. However, no testing has been done in hosts genetically selected for seizure susceptibility which may be more sensitive to the effects of ivermectin than other animals. This was done in the present experiments with seizure prone and seizure resistant mice infested with Syphacia obvelata (pinworm). These subjects were treated daily with oral ivermectin in their drinking water every other week for six weeks, for a total of 21 days. The treatment cleared the mice of the pinworm infestation, but did not alter the seizure susceptibility or binding parameters of [3H]flunitrazepam in either of the selected lines.
Diggs
H E
HE
Veterans Administration Medical Center, Animal Research Service, Portland, OR 97207.
Feller
D J
DJ
Crabbe
J C
JC
Merrill
C
C
Farrell
E
E
D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000494:pharmacology*; D001923:Brain Chemistry; D000431:Ethanol; D005445:Flunitrazepam / Q000378:metabolism; D007559:Ivermectin / Q000494:pharmacology*; D051379:Mice; D010063:Ovum; D010124:Oxyuroidea; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced*
D011963:Receptors, GABA-A; D000431:Ethanol; D005445:Flunitrazepam; D007559:Ivermectin; D001640:Bicuculline