[Metabolism of 14C-labeled urea in conventional and bacteria-free guinea pigs].
This report deals with the utilization of 14C-labeled urea in antibiotically decontaminated, bacteria-free guinea pigs using intragastric resp. intraperitoneal administration route. With conventional animals 52% of the intragastrically administered 14C dose can be demonstrated in the exhaled air, 1.2% in organs and 41% in the urine. 1.8% were found in intestinal and faecal contents. In bacteria-free animals 29% of the activity appeared in the exhaled air, 52% in urine and 2% remain in the intestinal tract, feces and animal body. Intraperitoneal administration of 14C urea revealed 17% resp. 14% in the exhaled air, 72% resp. 66% in urine and 2% resp. 3% in intestinal tract, feces and animal body in conventional resp. bacteria-free guinea pigs.
Juhr
N C
NC
Abteilung für Nuklearmedizin, Klinikum Steglitz, Freie, Universität Berlin.
Franke
J
J
D000818:Animals; D006168:Guinea Pigs / Q000378:metabolism*; D008297:Male; D013047:Specific Pathogen-Free Organisms; D014508:Urea / Q000493:pharmacokinetics*
D014508:Urea
Stoffwechsel von 14C-markiertem Harnstoff bei konventionellen und bakterienfreien Meerschweinchen.