[Concentration of cefotaxime in the exudate from ischemic ulcer after systemic and regional administration].
We evaluated the concentration of cefotaxime in the exudate from ischemic leg ulcers in 9 subjects with severe obstructive arterial disease. The administration of the drug was either systemic (1 g in 250 ml of saline given in 30 min) or regional at a vein of the foot while a tourniquet was applied at the level of the thigh during 30 min. Hygroscopic discs were used to collect samples of ulcer exudate at hourly intervals for 4 hr. Cefotaxime concentration was determined by HPL chromatography. A significantly greater concentration of antibiotic was obtained with regional as compared to systemic administration (46 +/- 16 vs 25 +/- 14, p less than 0.01) and a greater percentage of patients attained MIC 90. A stable concentration of the drug was observed during the 4 hr period indicating a decreased rate of elimination of the antibiotic from the ulcer tissue. Thus, regional administration of antibiotics affords greater concentration than systemic administration, for treatment of ischemic leg ulcers.
Acevedo
A
A
Servicio de Cirugía, Hospital del Salvador, Facultad de Medicina, Universidad de Chile, Santiago.
Schoop
W
W
D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000008:administration & dosage / Q000378:metabolism*; D002511:Cephalosporins / Q000008:administration & dosage / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007871:Leg Ulcer / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D002439:Cefotaxime
Concentración de cefotaxima en el exudado de úlceras isquémicas despúes de administración sistémica y regional.