Levodopa-responsive parkinsonism in a patient with Down's syndrome.
We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.
Singer
C
C
Department of Neurology, University of Miami School of Medicine, Fla.
Sanchez-Ramos
J
J
Weiner
W J
WJ
D000203:Activities of Daily Living; D002230:Carbidopa / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004314:Down Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D007980:Levodopa; D002230:Carbidopa