[Are there glutamatergic, anti-GABAergic or antiglycinergic components in the action mechanism of adamantamines? Study of convulsions induced by amantadine or 1-adamantylcyclopentanamine in mice].
Convulsions induced on mice by a dose of 200 mg/kg i.p. of amantadine (Ama) or 1-adamantylcyclopentanamine (Ad1) were studied with tricyclic antidepressants (imipramine, desipramine, chlorimipramine), possessing antiglutamatergic properties, or with GABA-linoleamide, a centrally acting GABAergic drug, or with glycine-linoleamide, a centrally acting glycinergic drug, or with glutamic acid palmitamide, a centrally acting glutamatergic drug. The results of these studies could suggest the existence of important glutamatergic and anti-GABAergic components and, probably, of a slight antiglycinergic activity in the pharmacological action profile of the Ad1. Moderate glutamatergic and anti-GABAergic components could operate in the Ama's mechanism of action.
Vamvakides
A
A
Laboratoires CHROPI, Paris.
D000547:Amantadine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D018756:GABA Antagonists; D005971:Glutamates / Q000737:chemistry; D005998:Glycine / Q000037:antagonists & inhibitors / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012640:Seizures / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
D003292:Convulsants; D018756:GABA Antagonists; D005971:Glutamates; C071452:adamantylcyclopentanamine; D005680:gamma-Aminobutyric Acid; D000547:Amantadine; D005998:Glycine
Y a-t-il des composantes glutamatergiques, anti-GABAergiques ou antiglycinergiques dans le mécanisme d'action des adamantamines? Etude des convulsions induites par l'amantadine ou la 1-adamantylcyclopentanamine chez la souris.