title: Chloracne associated with employment in the production of pentachlorophenol.
abstract: To evaluate the association between exposure to pentachlorophenol (PCP) and the occurrence of chloracne, we studied the medical and personnel records for individuals employed in the manufacturing of PCP. Forty-seven cases of chloracne were identified among 648 workers (7.0%) assigned to PCP production at a single plant between 1953 and 1978. The annual incidence rate varied considerably, ranging from 0 (in 1953) to 1.46 (in 1978). No linear trend in the risk of chloracne was observed with the duration of employment in the pentachlorophenol department. Workers with a documented episode of direct skin contact with PCP had a significantly increased risk of chloracne compared with workers who did not have a documented episode of direct skin contact (cumulative incidence ratio = 4.6; 95% confidence interval 2.6-8.1). Our results confirm that chloracne is associated with exposure to PCP contaminated with hexachlorinated, heptachlorinated, and octachlorinated dibenzo-p-dioxins and dibenzofurans.
authors: Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226.
authors: M A
authors: MA
authors: O'Malley
authors: A V
authors: AV
authors: Carpenter
authors: M H
authors: MH
authors: Sweeney
authors: M A
authors: MA
authors: Fingerhut
authors: D A
authors: DA
authors: Marlow
authors: W E
authors: WE
authors: Halperin
authors: C G
authors: CG
authors: Mathias
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D002617:Chemical Industry; D002733:Chlorophenols / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D003877:Dermatitis, Contact / Q000209:etiology; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007087:Illinois / Q000453:epidemiology; D015994:Incidence; D010416:Pentachlorophenol / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D002733:Chlorophenols; D010416:Pentachlorophenol