Internal calcium-binding proteins.
Ca(2+)-ions play a key role in the regulation of many cellular processes and impairment of calcium homeostasis has been implicated in several diseases. Intracellularly the Ca(2+)-signal is transmitted by two families of proteins, the 'EF-hand'- and the Ca(2+)-dependent and phospholipid binding proteins. Their protein and gene structures as well as possible functional roles are summarized.
Heizmann
C W
CW
Department of Pediatrics, University of Zürich, Switzerland.
Schäfer
B W
BW
D000595:Amino Acid Sequence; D000818:Animals; D017302:Annexins; D002135:Calcium-Binding Proteins / Q000737:chemistry*; D002147:Calmodulin / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000737:chemistry; D011487:Protein Conformation
D017302:Annexins; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D010743:Phospholipids