Unusual lymphocyte subset distribution in some depressed patients.
Depression has been previously associated with immunologic dysfunction. The lymphocyte subsets of 10 patients with major depression were found to show a mean T4-T8 (helper-suppressor) ratio lower than that of controls, a difference attributable to increased numbers of suppressor cells in the depressed group. One possible cause of increased suppressor cells is prior or current viral infection.
Wilson
S N
SN
Department of Psychiatry, Massachusetts General Hospital, Boston.
Surman
O S
OS
Colvin
R
R
Ozonoff
D
D
Gelenberg
A J
AJ
Jenike
M A
MA
Manschreck
T
T
Pato
C
C
D000328:Adult; D003866:Depressive Disorder / Q000150:complications / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000145:classification / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications / Q000276:immunology