title: [Undesirable drug reactions in simultaneous administration of high-dosage phenobarbital and beta-lactam antibiotics].
abstract: The present paper reports on a striking increase in undesirable drug induced reactions during simultaneous administration of high-dosage phenobarbital and beta-lactam antibiotics to children in intensive care. In a 30-month study period, reactions which had to be classified as drug-induced were seen in 24 out of a total of 49 children (mainly exanthematous skin reactions, in some cases severe). The complications were mainly observed in patients receiving a combination of cefotaxime and phenobarbital. Etiologically, a toxic reaction to the combination of hepatically metabolized beta-lactam antibiotics with an enzyme-inducing drug must be considered in addition to the allergenic potential of the individual components.
authors: Abt. Klinische Pharmakologie, Klinikum der J. W. Goethe Universität, Frankfurt/Main.
authors: S
authors: S
authors: Harder
authors: W
authors: W
authors: Schneider
authors: Z U
authors: ZU
authors: Bae
authors: U
authors: U
authors: Bock
authors: S
authors: S
authors: Zielen
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002439:Cefotaxime / Q000009:adverse effects; D002648:Child; D003875:Drug Eruptions / Q000209:etiology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D002439:Cefotaxime; D010634:Phenobarbital
vernacular_title: Unerwünschte Arzneimittelreaktionen bei gleichzeitiger Gabe von hochdosiertem Phenobarbital und Betalaktam-Antibiotika.