Autologous transplantation as a treatment for progressive supranuclear palsy.
Autologous transplantation of the adrenal gland has been attempted as a treatment for severe Parkinson's disease with limited success. Progressive supranuclear palsy (PSP), a more aggressive neurological entity of similar pathology, is due to a loss of dopamine in the caudate nucleus and putamen. The autologous transplant procedure has been performed on three PSP patients in an effort to restore dopamine to the caudate nucleus and putamen. The rationale and preliminary results of the transplantation procedure are reviewed in this article.
Ward-Smith
P A
PA
Brain Tumor Institute, Kansas City, Missouri 64132.
Berry
P
P
D000203:Activities of Daily Living; D000313:Adrenal Medulla / Q000637:transplantation*; D002421:Caudate Nucleus; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000451:nursing / Q000503:physiopathology / Q000601:surgery*; D014182:Transplantation, Autologous / Q000379:methods; D016042:Transplantation, Heterotopic / Q000379:methods