Insulin levels and 125I-insulin binding to monocytes in a non obese pregnant woman with polycystic ovarian disease.
Insulin responses to oral glucose, 125I-insulin binding to monocytes and androgen profiles were studied in a 25-year-old non obese woman with polycystic ovarian disease pre pregnancy, during pregnancy and in the post partum period. The patient was hyperinsulinaemic both pre and post pregnancy, however, her insulin resistance worsened during pregnancy. 125I-insulin receptor binding to monocytes during pregnancy decreased primarily due to a decrease in receptor number. This decreased binding was attributed to the down regulatory effect of the basal hyperinsulinaemia. Androgen levels were elevated pre and post pregnancy and suppressed during pregnancy.
Mahabeer
S
S
Faculty of Medicine, Department Chemical Pathology, University of Natal, Congella, RSA.
Norman
R J
RJ
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007457:Iodine Radioisotopes; D007700:Kinetics; D009000:Monocytes / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011644:Puerperal Disorders / Q000097:blood; D011972:Receptor, Insulin / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin