Translocation (14;21)(q11;q22) in a woman with history of abortions and a child with Down's syndrome.
A translocation (14;21)(q11;q22) was observed in a woman with history of abortions and in her child with Down's syndrome. This appears to be the first report of such a translocation with no centric fusion between the acrocentric chromosomes leading to a count of 45 chromosomes in the carrier and giving birth to a Down's syndrome child.
Sudha
T
T
Department of Genetics, University of Madras, India.
Gopinath
P M
PM
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002883:Chromosomes, Human, Pair 14 / Q000648:ultrastructure*; D002891:Chromosomes, Human, Pair 21 / Q000648:ultrastructure*; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics; D006801:Humans; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic