title: Modification of glybenclamide hypoglycaemia by verapamil in rabbits.
abstract: The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycaemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycaemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycaemic response of glybenclamide.
authors: Department of Pharmacology, L.L.R.M. Medical College, Meerut.
authors: K K
authors: KK
authors: Saxena
authors: S
authors: S
authors: Lata
authors: R S
authors: RS
authors: Saxena
authors: A
authors: A
authors: Kumar
authors: V K
authors: VK
authors: Srivastava
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D014700:Verapamil; D005905:Glyburide