Genealogical and genetical African admixture estimations, blood pressure and hypertension in a Caribbean community.
This study examines the relationships between blood pressure, prevalence of hypertension, and the degree of black African admixture in the population of the Caribbean Island of La Désirade which is homogeneous with respect to the environmental factors and for which the socioeconomical stratification does not match racial origin. The degree of admixture was estimated by using both genealogical information and genetic markers. Blood pressure was repeatedly measured using an automatic sphygmomanometer. After adjustment for age, sex, ponderal index, Na/K urinary ratio, and clinical alcoholism, blood pressure and prevalence of hypertension were found to be significantly higher for the individuals having the largest proportion of genes of black origin. Identical results were obtained when either genetic markers or genealogical information were used as an individual--estimator of admixture.
Darlu
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P
INSERM, Unité d'Epidémiologie génétique, Université Paris, France.
Sagnier
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PP
Bois
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E
D000017:ABO Blood-Group System / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People / Q000235:genetics*; D001789:Blood Group Antigens / Q000235:genetics; D001794:Blood Pressure; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007983:Lewis Blood Group Antigens / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000235:genetics; D014900:West Indies; D044465:White People / Q000235:genetics
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D006680:HLA Antigens; D006454:Hemoglobins; D007129:Immunoglobulin Gm Allotypes; D007983:Lewis Blood Group Antigens; D012204:Rh-Hr Blood-Group System