Experimental study of the effects of a new protective cream against skin irritation provoked by the organic solvents n-hexane, trichlorethylene and toluene.
In a first experiment, the potential effectiveness of three cream formulations (A, B, C) against skin irritation due to n-hexane was evaluated using a guinea pig model. Semi-quantitative histopathological assessment of skin lesions were carried out. Due to interesting protective effects, cream formulation A (Travabon) was selected and further investigated. In a second series of experiments, this cream showed some protective effects against irritation due to toluene, but was not found efficacious against trichlorethylene irritation.
Lachapelle
J M
JM
Department of Occupational Medicine, Louvain University, Brussels, Belgium.
Nouaigui
H
H
Marot
L
L
D000818:Animals; D001706:Biopsy; D009783:Dermatitis, Occupational / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006168:Guinea Pigs; D006586:Hexanes / Q000009:adverse effects*; D008743:Methyl Parathion / Q000627:therapeutic use*; D009824:Ointments / Q000627:therapeutic use*; D010278:Parathion / Q000031:analogs & derivatives*; D012867:Skin / Q000473:pathology; D012869:Skin Absorption / Q000187:drug effects; D014050:Toluene / Q000009:adverse effects*; D014241:Trichloroethylene / Q000009:adverse effects*
D006586:Hexanes; D009824:Ointments; D014241:Trichloroethylene; C026385:n-hexane; D014050:Toluene; D008743:Methyl Parathion; D010278:Parathion