Why do cancer cells have such a high glycolytic rate?
The high glycolytic rate of most tumor cells has puzzled biochemists for a long time. In the tumor, glucose is aerobically converted to lactate in the cytoplasm rather than being oxidized in the mitochondria. The molecular mechanisms underlying this phenomenon are still fragmentary. The present study supports the view that the origin of the glucose disposal by the tumor is multifactorial.
Argilés
J M
JM
Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
López-Soriano
F J
FJ
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000502:physiology; D004798:Enzymes / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
D004798:Enzymes; D007773:Lactates; D009243:NAD; D019344:Lactic Acid; D000251:Adenosine Triphosphatases; D005947:Glucose