[Electrocardiographic and echocardiographic changes during antihypertensive therapy].
To investigate the changes of electrocardiographic and echocardiographic indexes of left ventricular hypertrophy (LVH) during antihypertensive therapy, 100 hypertensive patients, mean age 46 years, were studied in pretreatment condition and during 12 months of antihypertensive therapy. In pretreatment condition, 83 patients showed LVH by echocardiography (echo; left ventricular mass index greater than 130 g/m2) and 30 patients had LVH by electrocardiography (ECG) (Sokolow index greater than 35 mm). In comparison to echo index of LVH, Sokolow index showed a sensibility of 34% and a specificity of 88%. Both LV mass echo index and ECG index significantly decreased after 3 months but in different way. LV mass index mainly decreased after 12 months, whereas Sokolow index particularly decreased after 6 months, with no further changes in the subsequent months. After 12 months of therapy, the LV mass echo index normalized in 19% of the patients (16/83) and Sokolow index normalized in 57% (17/30). ECG sensibility and specificity, in comparison to LV mass echo, was 20% and 100%, respectively. Thus, ECG appears less sensitive than echo in the detection of LVH. During antihypertensive therapy ECG index of LVH normalized more precociously and to a greater extent than the echo index. However, the normalization of LVH by ECG does not necessarily mean that a complete anatomic regression of LVH has occurred.
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Istituto di Cardiologia, Università degli Studi, Cagliari.
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D000070:Acebutolol / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use; D006332:Cardiomegaly / Q000175:diagnosis*; D002752:Chlorthalidone / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007192:Indenes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D010096:Oxprenolol / Q000627:therapeutic use; D010869:Pindolol / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use; D013999:Timolol / Q000627:therapeutic use
D000959:Antihypertensive Agents; D007192:Indenes; D011412:Propanolamines; D010096:Oxprenolol; C002989:indenolol; D000070:Acebutolol; D013999:Timolol; D002216:Captopril; D010869:Pindolol; D009543:Nifedipine; D002752:Chlorthalidone
Modificazioni elettrocardiografiche ed ecocardiografiche durante terapia antipertensiva.