Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine.
The bioavailability of Mg from different preparations after oral intake has been evaluated by measuring the Mg elimination in 24-hour urine during placebo and treatment periods in 18 normal female students receiving 15-20.6 mmol/day. The urine elimination was increased 0.9-1.3 mmol/24 h by (a) tablets containing Mg citrate/Mg lactate 5 mmol three times a day; (b) tablets containing Mg citrate/Mg lactate and Mg hydroxide, 5 mmol three times a day; (c) tablets containing Mg hydroxide (Emgesan 10.3 mmol) twice a day; (d) solutions with Mg chloride (0.5 mmol/ml) 10 ml three times a day. There was no statistical difference in urine elimination after intake of the different preparations. The differences in Mg elimination/24 h discriminated between control and treatment groups just as well as or better than differences calculated on the basis of Mg/creatinine ratios.
Bøhmer
T
T
Department of Medicine B, Aker Hospital, Oslo, Norway.
Røseth
A
A
Holm
H
H
Weberg-Teigen
S
S
Wahl
L
L
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011897:Random Allocation
D003404:Creatinine; D008274:Magnesium