title: Atrial natriuretic peptide release responds to atrial stretch and not to atrial pressure: observations during pericardiocentesis in a young woman.
abstract: The effect of pericardiocentesis on the plasma concentration of atrial natriuretic peptide was studied in a patient with cardiac tamponade. Plasma atrial natriuretic peptide concentrations rose sharply from 42 pmol l-1 to a maximum of 150 pmol l-1 with a corresponding fall in mean right atrial pressure from 20 mmHg to 6 mmHg. Our results suggest that atrial 'stretch' (or transmural pressure) rather than atrial pressure per se, is the primary stimulus for atrial natriuretic peptide release in man.
authors: Cobbold Laboratories, Middlesex Hospital, London.
authors: A C
authors: AC
authors: Ong
authors: C E
authors: CE
authors: Handler
authors: J D
authors: JD
authors: Slater
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000096:biosynthesis* / Q000502:physiology; D001794:Blood Pressure; D002305:Cardiac Tamponade / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D010492:Pericardiectomy; D011311:Pressoreceptors / Q000503:physiopathology; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin