Evidence of T-cell activation and potential cytokine action in human endometrium.
Antigenic epitopes have been described whose expression characterizes early or late stages of activation of T-cells. In this study the expression of early activation antigen, interleukin-2 receptor was compared with the expression of late activation antigens, HLA-DR, HLA-DP, and HLA-DQ molecules of the major histocompatibility complex II, and very late activation antigen, VLA-1 of the integrin superfamily of molecules in 43 human endometria. These molecules were localized by their reactivity with monoclonal antibodies in an avidinbiotin-complex procedure. Interleukin-2 receptor was not expressed in human endometria; however, endometrial T-cells within lymphoid aggregates, some scattered in endometrial stroma and a few within epithelium, expressed HLA-DR, HLA-DP, HLA-DQ, and VLA-1. In addition, expression of the receptor of interferon-gamma, a product of activated T-cells, was observed on endometrial epithelium. Evidence for activation of T-cells and expression of interferon-gamma receptor in human endometrial epithelium suggests that endometrium may be an active site for cytokine action.
Tabibzadeh
S
S
Department of Pathology, City Hospital Center, Elmhurst, New York 11373.
D000328:Adult; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000378:metabolism*; D001685:Biological Factors / Q000096:biosynthesis*; D016207:Cytokines; D004717:Endometrium / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006681:HLA-D Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D008213:Lymphocyte Activation / Q000502:physiology*; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000378:metabolism / Q000502:physiology; D017471:Receptors, Interferon; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D001685:Biological Factors; D016207:Cytokines; D006681:HLA-D Antigens; D007370:Interferon Type I; D011971:Receptors, Immunologic; D017471:Receptors, Interferon