Structure of vacuolar proton pumps.
At the present time, knowledge of the structure of the proton-translocating ATPase responsible for urinary acidification is far from complete. Key issues awaiting resolution are full definition of subunit structure and an understanding of the interactions among functional domains of this complex hetero-oligomer. Such a detailed analysis is required to begin study of the biogenesis of the vacuolar proton pump and to elucidate the complexities of its molecular regulation.
Stone
D K
DK
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235.
Crider
B P
BP
Xie
X S
XS
D000136:Acid-Base Equilibrium / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007671:Kidney Concentrating Ability / Q000502:physiology; D009399:Nephrons / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000145:classification / Q000502:physiology*; D014617:Vacuoles / Q000201:enzymology
D006180:Proton-Translocating ATPases