Histological evaluation of biocompatible orthopaedic polymer.
The biocompatibility of biocompatible orthopaedic polymer implant materials was studied in subcutaneous and bony tissue of rats and rabbits. The tissue response was evaluated by histological techniques. No bone induction capacity of biocompatible orthopaedic polymer could be observed. In rabbits, the presence of plasma cells was significantly higher than in rats. The biomaterial showed some signs of biodegradation and was not very biocompatible.
Wu
S C
SC
Department of Biomaterials, ACTA Free University, Amsterdam, The Netherlands.
Klein
C P
CP
van der Lubbe
H B
HB
de Groot
K
K
van den Hooff
A
A
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000473:pathology*; D003238:Connective Tissue / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D062109:Dermatologic Surgical Procedures; D005347:Fibroblasts / Q000473:pathology; D008297:Male; D008422:Materials Testing; D010586:Phagocytes / Q000473:pathology; D011108:Polymers; D019736:Prostheses and Implants; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology*; D013977:Tibia / Q000473:pathology / Q000601:surgery
D001672:Biocompatible Materials; D011108:Polymers