[Bronchial tolerance to inhalation of beclomethasone. Histologic and microbiologic study in asthmatic patients].
The aim of the present study was to investigate the effects of a three months' treatment with beclomethasone dipropionate on the bronchial mucosa of asthmatic patients. Eleven patients suffering from a mild chronic asthma treated with inhaled salbutamol and theophylline were randomly assigned to receive either 1000 mu g of beclomethasone dipropionate (6 patients) or an aerosolized placebo (5 patients) in a double-blind manner. Bronchial biopsies and bronchial secretions were obtained through a fiberoptic procedure at the beginning and the end of the study. Repeated clinical and spirometric investigations were performed each month. Inter- and intra-group mean changes of clinical symptoms and of spirometric values were not significantly different. Pathogens were rarely found in bronchial aspirates and their occurrence did not seem to be influenced by the beclomethasone therapy. Sixty percent of the bronchial biopsies displayed pathological changes of the mucosa that observed at the beginning and at the end of the study; however, no sign of mucosal atrophy was noted.
Fournier
M
M
Hôpital Beaujon, Service de Pneumologie et Réanimation, Clichy.
Renon
D
D
Le Roy-Ladurie
F
F
Pappo
M
M
Pariente
R
R
D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000627:therapeutic use*; D001980:Bronchi / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D013147:Spirometry
D010919:Placebos; D001507:Beclomethasone
Tolérance bronchique à l'inhalation de béclométasone. Etude histologique et microbiologique chez l'asthmatique.