title: Direct separation of amino acid enantiomers using a chiral crown ether stationary phase. Application to 2-amino-omega-phosphonoalkanoic acids.
abstract: The resolution of a series of 2-amino-omega-phosphonoalkanoic acid enantiomers using a crown ether chiral stationary phase is described. The method is applicable to other primary amino acid and shows some advantages over chiral derivatization with fluorometric detection. Optical isomers of under 0.5% may be quantified.
authors: Department of Pharmacology, School of Medical Sciences, University of Bristol, U.K.
authors: P M
authors: PM
authors: Udvarhelyi
authors: D C
authors: DC
authors: Sunter
authors: J C
authors: JC
authors: Watkins
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D004988:Ethers, Cyclic; D007536:Isomerism; D009943:Organophosphorus Compounds / Q000032:analysis
chemical_list: D000596:Amino Acids; D004988:Ethers, Cyclic; D009943:Organophosphorus Compounds