title: Enhancement of the immune response in mice by Astragalus membranaceus extracts.
abstract: Astragalus membranaceus extracts injected into normal mice or mice immunodepressed by cyclophosphamide or radiation treatment or by aging are able to enhance the antibody response to a T-dependent antigen. Optimal conditions for maximum effect have been established in normal C3H/HeJ and (C57B1/10 x DBA/2)F1 mice. Enhancement of the antibody response was associated with increase of Th cell activity in normal and immunodepressed mice. The biological activity of endotoxin-free extracts is dependent on the carbohydrate content.
authors: Laboratory of Pathology, ENEA C.R.E., Rome, Italy.
authors: K S
authors: KS
authors: Zhao
authors: C
authors: C
authors: Mancini
authors: G
authors: G
authors: Doria
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D014301:Trinitrobenzenes