[Loss of dendritic spines in Alzheimer's disease].
Neurones from five patients with Alzheimer's disease were studied semi-quantitatively on Golgi impregnated samples of cerebral cortex. They showed a dramatic reduction in dendritic spine number of pyramidal and non-pyramidal cells of all neocortical layers, as compared with control samples matched for age. Dendritic spine loss could be an initial phenomenon in Alzheimer's disease pathology.
el Hachimi
K H
KH
Division Montyon, Hôpital de la Salpêtrière, Paris.
Foncin
J F
JF
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D003712:Dendrites / Q000473:pathology*; D006801:Humans; D008875:Middle Aged
Perte des épines dendritiques dans la maladie d'Alzheimer.