title: Influence of local injection of 5,7-DHT and 6-OH-DA into the neocortex on learning and exploratory behavior of rats in the open field.
abstract: The features of the exploratory behavior in the open field, of the learning of a conditioned-reflex food-procuring reaction, and of the shift in the level of biogenic amines of the brain was studied in Wistar rats with local injections of the specific neurotoxins 6-hydroxydopamine (6-OH-DA) and 5,7-dihydroxytryptamine (5,7-DHT). It was shown that damage to the structure of the serotoninergic or catecholaminergic systems of the frontal cortex and hippocampus caused by local injection of 6-OH-DA and 5,7-DHT into the neocortex is accompanied by multidirectional changes in the exploratory behavior and learning of the animals.
authors: Laboratory of Neurophysiology of Integrative Brain Activity, A. I. Karaev Institute of Physiology, SSR, Baku.
authors: Kh Yu
authors: KhY
authors: Ismailova
authors: G G
authors: GG
authors: Gasanov
authors: T P
authors: TP
authors: Semenova
authors: N V
authors: NV
authors: Bobkova
authors: I V
authors: IV
authors: Nesterova
authors: E A
authors: EA
authors: Gromova
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology; D005106:Exploratory Behavior / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D007858:Learning / Q000187:drug effects*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D009411:Nerve Endings / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology
chemical_list: D001679:Biogenic Amines; D002395:Catecholamines; D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D016627:Oxidopamine