title: Alteration of aliphatic lipid proton NMR linewidths by malignant tumors in guinea pigs.
abstract: Water-suppressed proton nuclear magnetic resonance spectroscopy was used to observe plasma lipoprotein lipid methyl and methylene resonances from guinea pigs which had been injected with viable or heat-killed line 1 or line 10 tumor cells or sterile oil. It was shown that the widths of these resonances became significantly sharper as the number of tumor cells grew. Plasma from tumor-free control animals showed no change in the NMR linewidths. It is concluded that the changes observed reflect a specific host response to viable tumor cells, and in these models there is a reciprocal relationship between the number of viable tumor cells and the linewidths of plasma lipoprotein methyl and methylene resonances.
authors: Department of Radiology, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
authors: E T
authors: ET
authors: Fossel
authors: H F
authors: HF
authors: Dvorak
authors: J M
authors: JM
authors: Carr
authors: J
authors: J
authors: McDonagh
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000097:blood / Q000175:diagnosis*; D006168:Guinea Pigs; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D008074:Lipoproteins