[Studies on mechanism of carcinogenesis in vitro. IV. Studies on relationship between frequency of chromosome 15 monosomy and malignant expression of different clones from malignantly transformed baby hamster lung cells (BHL B4)].
The proceeding of malignantly transformed rodent cells in vitro is often accompanied by regular variation of chromosome numbers and structures. In order to clarify the relationship between them, we obtained five clones C1-1-5-from BHL B4, cell line, and analysed their biological characteristics. Results showed a positive correlation between frequency of chromosome 15 monosomy, it is suggested that suppressive gene of malignant phenotype be located on chromosome 15.
Li
S
S
Institute of Oncology, Beijing.
D000818:Animals; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002872:Chromosome Deletion; D006224:Cricetinae; D005347:Fibroblasts / Q000166:cytology; D015972:Gene Expression Regulation, Neoplastic; D008168:Lung / Q000166:cytology*; D008647:Mesocricetus; D008769:Methylnitronitrosoguanidine; D009006:Monosomy; D009368:Neoplasm Transplantation; D010641:Phenotype
D008769:Methylnitronitrosoguanidine