Blood pressure and red cell sodium transport changes following salt load in patients with glomerulonephritis.
A group of 44 patients with chronic glomerulonephritis (GN) and 20 healthy subjects were investigated under the conditions of normal dietary NaCl intake and after one week of salt load with a daily addition of 5 g NaCl per os. After the salt load, the mean blood pressure increased significantly in 47% subjects (salt-sensitive) and their natriuretic response was accompanied by an increase of glomerular filtration rate. The rates of ouabain-sensitive (OST) and furosemide-sensitive transport (FST) were decreased in patients with chronic GN even before salt loading which did not change these values. The lower OST rate can be explained by a reduced affinity for internal Na+. A decreased affinity of the Na(+)-K+ cotransport system for internal Na+ was detected only in hypertensive GN patients. In our study, no relationship between salt-sensitivity and red cell sodium transport either in normotensive or in hypertensive GN patients was found.
Kuzemková
L
L
Institute for Clinical and Experimental Medicine, Prague.
Stríbrná
J
J
Janata
V
V
D000328:Adult; D001692:Biological Transport; D001794:Blood Pressure; D001835:Body Weight; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007700:Kinetics; D008297:Male; D009318:Natriuresis; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage*
D012982:Sodium, Dietary; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D011188:Potassium