title: Folate antagonists: toward improving the therapeutic index and development of new analogs.
authors: Program of Developmental Therapy and Clinical Investigation, New York, NY.
authors: J R
authors: JR
authors: Bertino
mesh_terms: D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004351:Drug Resistance / Q000235:genetics; D005493:Folic Acid Antagonists / Q000378:metabolism / Q000627:therapeutic use*; D005784:Gene Amplification; D006801:Humans; D008727:Methotrexate / Q000378:metabolism / Q000627:therapeutic use*; D009154:Mutation; D011799:Quinazolines / Q000378:metabolism / Q000627:therapeutic use*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D016597:Trimetrexate
chemical_list: D005493:Folic Acid Antagonists; D011799:Quinazolines; D013762:Tetrahydrofolate Dehydrogenase; D016597:Trimetrexate; D008727:Methotrexate