[Cushing's syndrome: the diagnostic and treatment problems in 27 cases].
Problems of diagnosis and treatment were analyzed in 27 patients with Cushing syndrome (25 confirmed by anatomic findings) followed for a mean of 50 months. The etiology was Cushing disease in 14 (52%), suprarenal tumor in 9 (33%) and ectopic secretion of ACTH in 4 (15%). Determination of plasma cortisol levels at 4 PM or 11 PM was a highly sensitive test for the presence of this syndrome (100%). High resolution computed tomography was considerably more effective than conventional X ray studies of the sella in patients with Cushing disease (42 vs 20%). Treatment has been totally effective in all patients with benign suprarenal lesions. Cure was obtained in 64% of patients with pituitary lesions and 0% of patients with Cushing syndrome associated to malignancy.
González
G
G
Departamento de Endocrinología, Metabolismo y Nutrición, Hospital Clínico, P Universidad Católica de Chile, Santiago.
Arteaga
E
E
Rodríguez
J A
JA
López
J M
JM
Michaud
P
P
Codner
E
E
D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D000293:Adolescent; D000302:Adrenal Cortex / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D002648:Child; D002677:Chile / Q000453:epidemiology; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
Síndrome de Cushing: problemas de diagnóstico y tratamiento en 27 casos.