Tiopronin-induced lichenoid eruption in a patient with liver disease and positive patch test reaction to drugs with sulfhydryl group.
A 62-year-old woman suffering from liver cirrhosis developed lichenoid eruptions after 2 years of treatment with tiopronin. The lesions healed spontaneously within a month after withdrawal of the drug. In patch testing, the patient reacted positively, not only to tiopronin, but also to captopril and D-penicillamine, neither of which she had ever taken before. The provocation test was positive only to tiopronin, and its histological findings revealed lichenoid reaction. It is suggested that the sulfhydryl group may play a role in the etiology of tiopronin-induced lichenoid drug eruption.
Kurumaji
Y
Y
Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Japan.
Miyazaki
K
K
D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000209:etiology* / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy; D008875:Middle Aged; D012882:Skin Tests; D008625:Tiopronin / Q000009:adverse effects*
D008625:Tiopronin