[Virological monitoring in subjects with HIV infection under treatment with zidovudine (AZT)].
The authors report preliminary results of the virological evaluation (performed by serum p24 antigen detection and HIV isolation from peripheral blood lymphocytes) of Zidovudine therapy in 64 anti-HIV positive subjects. Data presented indicate that the administration of therapeutic doses of the drug can efficiently and precociously inhibit viral replication, suggesting that the clinical benefits of the therapy may be related to the anti-viral activity of the drug. However, the anti-viral efficacy of Zidovudine seems to be of limited length; in fact a reactivation of viral replication was observed in most patients during the study.
Fiore
J R
JR
Clinica di Malattie Infettive, Università di Bari.
Angarano
G
G
Fico
C
C
Lo Caputo
S
S
Fracasso
C
C
Barile
M
M
Pastore
G
G
D015683:Gene Products, gag / Q000032:analysis; D006678:HIV / Q000302:isolation & purification* / Q000502:physiology; D016655:HIV Core Protein p24; D015658:HIV Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D014758:Viral Core Proteins / Q000032:analysis; D014766:Viremia / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000627:therapeutic use*
D015683:Gene Products, gag; D016655:HIV Core Protein p24; D014758:Viral Core Proteins; D015215:Zidovudine
Monitoraggio virologico in soggetti con infezione da HIV in trattamento con zidovudina (AZT).