The clinical significance of beryllium.
The carcinogenicity of beryllium for the human organism by inhalation has been established. Biochemical properties of this strong carcinogenic element are related to its intake, transport and accumulation in the body, as well as to cell division, DNA synthesis, enzyme inhibition, and gene expression. Other biochemical properties of beryllium are associated with its adjuvant action. Diagnosis and possible treatment of beryllium toxicity are also outlined.
Aller
A J
AJ
Department of Biochemistry and Molecular Biology, University of León, Spain.
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D001608:Beryllium / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D002273:Carcinogens / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy; D009153:Mutagens / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*
D000276:Adjuvants, Immunologic; D002273:Carcinogens; D009153:Mutagens; D001608:Beryllium