Plasma concentrations of endothelin in man: arterio-venous differences and release during venous stasis.
Endothelin-1 is a recently described endothelium-derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 +/- 0.4 pmol l-1 was found, whereas the mean concentration in arterial plasma was 0.9 +/- 0.4 pmol l-1 (P less than 0.005). During venous stasis for 10 min the mean plasma concentration of IR-endothelin increased about twofold, from basal 1.1 +/- 0.3 pmol l-1 to 2.1 +/- 0.3 pmol l-1 (P less than 0.01). This manoeuvre may prove helpful to investigate the control of endothelin in vivo under a variety of pathological conditions.
Wagner
O F
OF
I Medizinische Universitätsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Vienna, Austria.
Nowotny
P
P
Vierhapper
H
H
Waldhäusl
W
W
D000328:Adult; D001158:Arteries; D003250:Constriction; D016232:Endothelins / Q000097:blood*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D014680:Veins
D016232:Endothelins