[Preliminary studies of T lymphocyte subsets in patients with neurologic diseases].
With immunofluorescence assay a preliminary study of T-cell subsets in the peripheral blood (PB) and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS), viral encephalitis, Guillain-Barré syndrome (GBS), tuberculous meningitis, and other neurological diseases (OND) was carried out. The results revealed that the T4+ percentage and T4+/T8+ ratio of PB as well as CSF increased, T8+ decreased in cases of MS. The changes of CSF T subsets in cases of (GBS) were similar to those in cases of MS. There was no difference in PB T subsets between GBS and the normal controls. The T4+/T8+ ratio of PB and CSF reduced in cases of tuberculous meningitis, and such changes were also found in PB of viral encephalitis patients. Therefore, it was demonstrated that the immunoregulatory dysfunctions were present in these neurological disorders, and the characters of the changes were different between infectious and autoimmune diseases.
Cao
L
L
Dept. of neurology first hospital, Nanjing Medical College.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014390:Tuberculosis, Meningeal / Q000276:immunology*
D000911:Antibodies, Monoclonal