Microfilament organization correlates with increased cellular content of gelsolin.
The relative amounts of intracellular gelsolin were determined in a number of human somatic cell hybrids and parental cell lines which greatly differ in their microfilament organizations. In contrast to the disruptive effect of gelsolin on actin filament formation in vitro, there is a correlation between the degree of microfilament organization and the amount of gelsolin within these cell lines.
Banyard
M R
MR
Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
Medveczyk
C J
CJ
Tellam
R L
RL
D008841:Actin Cytoskeleton / Q000648:ultrastructure*; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000502:physiology*; D002460:Cell Line; D003599:Cytoskeleton / Q000648:ultrastructure*; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000502:physiology; D018260:Gelsolin; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D015151:Immunoblotting; D008840:Microfilament Proteins / Q000032:analysis / Q000502:physiology*
D002135:Calcium-Binding Proteins; D018260:Gelsolin; D008840:Microfilament Proteins