Hemorrhage-induced regional brain thyrotropin-releasing hormone release in conscious rats measured by microdialysis.
The septum, nucleus accumbens and preoptic area in the brains of conscious, freely moving rats were perfused using microdialysis probes. The TRH concentration significantly increased in the septum after withdrawal of 30% of the total blood volume but remained at constant levels in the other brain areas. Also, high potassium dose-dependently stimulated TRH release in vivo. These results suggest that blood loss stimulates septal TRH release, probably by membrane depolarization of TRH-containing nerve terminals.
Okuda
C
C
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
Sawa
T
T
Harada
M
M
Miyazaki
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003956:Dialysis; D006470:Hemorrhage / Q000503:physiopathology*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D013973:Thyrotropin-Releasing Hormone; D011188:Potassium