[Serum anti-polytene chromosomes of Drosophila melanogaster antibody (AchrA) and systemic lupus erythematosus].
The determination of serum AchrA in patients with SLE(43) and other rheumatic diseases (ODRs, 109) and in 42 normal individuals was measured by indirect immunofluorescence assay (IIF) using the polytene chromosomes of the third instar larva of Drosophila melanogaster as the substrate. The results showed that the serum AchrA was negative in all of the 42 normal individuals and the 109 patients with ORDs and the AchrA was positive in 19 (44%) of the patients with SLE. The patients with active SLE were found in 16 (84%) of the 19 AchrA positive group and 13 (54%) of the 24 AchrA negative group. The incidence of arthritis/arthralgia, photosensitivity, glomerulonephritis and anemia in the SLE patients were higher in the AchrA positive group than those in the AchrA negative group. In contrast, the patients with nephrotic syndrome were more common in the AchrA negative group than in the AchrA positive group. It is suggested that serum AchrA is extremely specific and more sensitive for SLE and that the finding of positive AchrA are usually associated with activity of SLE and renal involvement.
Xiao
Y L
YL
Chinese PLA General Hospital, Beijing.
Ding
Y Z
YZ
Shi
G Y
GY
D000293:Adolescent; D000328:Adult; D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D002875:Chromosomes / Q000276:immunology*; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male
D000974:Antibodies, Antinuclear