[Seroconversion following immunization with a plasma-derived vaccine against hepatitis B: study of a 3-injection protocol (0, 1, 6 months) in Brazzaville (Congo)].
The aim was to study the immunogenicity of a plasma-derived vaccine against Hepatitis B Virus administrated in 3 injections at month 0-1-6. Only subjects without HBs Ag and anti-HBc were vaccinated. The seroconversion rates were 79.21% at day 90, 77.50% at day 180 and 87.21% at day 210. At the same dates, the mean geometric titres of anti-HBs (mUI/ml) were respectively 115.01, 100.48 and 772.78. In all subjects, the vaccine was very well tolerated. This 3 injections protocol of vaccination instead of the classical 4 injections protocol significantly reduces the cost of vaccination and may enlarge its application.
Taty-Taty
R
R
Laboratoire de l'Hôpital Central des Armées, Brazzaville, Congo.
Saliou
P
P
Yala
F
F
Couroucé
A M
AM
Arthaud
M L
ML
Nerelli
B
B
Biendo
M
M
Wassoumbou
E
E
D000328:Adult; D003223:Congo; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D017325:Hepatitis B Vaccines; D006801:Humans; D008297:Male; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines
Séroconversion après immunisation par un vaccin plasmatique contre le virus de l'hépatite B: étude d'un protocole en 3 injections (0, 1, 6 mois) à Brazzaville (Congo).