[Treatment of hirsutism with spironolactone and progestagen combination].
The antiandrogenic activity of spironolactone was used for treating hirsutism in 76 women, 29 of whom also had acne. Midcycle vaginal bleeding was observed in 21 patients under spironolactone 75 mg per day. This side-effect disappeared after a progestagen administered 10 days each month was added to the treatment. With this combination, spironolactone was well tolerated and effective in treating acne within the first months of administration, but in 61 percent of the patients at least 6 months were required to improve hirsutism.
Pugeat
M
M
Laboratoire de la Clinique Endocrinologique, Hôpital de l'Antiquaille, Hospices civils de Lyon.
Elmidani
M
M
Dechaud
H
H
Garoscio-Cholet
M
M
Lejeune
H
H
Tourniaire
J
J
D000152:Acne Vulgaris / Q000150:complications / Q000628:therapy; D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006628:Hirsutism / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D009653:Norprogesterones / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000627:therapeutic use*; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use*; D014592:Uterine Hemorrhage / Q000139:chemically induced
D009653:Norprogesterones; D045167:Progesterone Congeners; D013148:Spironolactone; C011214:demegestone
Traitement de l'hirsutisme par l'association de spironolactone et d'un progestatif.