title: [Calcium transport in endoplasmic reticulum of the rat liver during lipid peroxidation].
abstract: Some parameters of calcium transport in rat liver microsomes under conditions of lipoperoxidation activation modelled by antioxidant deficiency (AOD) were studied. This process was shown to be associated with a sharp stimulation of NADPH- and ascorbate-dependent lipid peroxidation in hepatocyte endoplasmic reticulum. The activation of lipid peroxidation was accompanied by disturbances in the kinetic properties of Ca2(+)-ATPase. This was paralleled with a considerable decrease of the ATP-dependent 45Ca-accumulation, increase in the passive permeability of microsomal vesicles for Ca2+ and Ca2+ elevation in the microsomal fraction. The AOD-induced diminution of the Ca2(+)-pump efficiency was slightly prevented by injections of rats with the antioxidants, alpha-tocopherol acetate and ionol which enable Ca2+ compartmentation correction in liver cytosol and membrane fractions.
authors: Iu I
authors: IuI
authors: Gubskiĭ
authors: M D
authors: MD
authors: Kurskiĭ
authors: O V
authors: OV
authors: Zadorina
authors: A N
authors: AN
authors: Fedorov
authors: T S
authors: TS
authors: Briuzgina
authors: N N
authors: NN
authors: Iurzhenko
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D000252:Calcium-Transporting ATPases; D002118:Calcium
vernacular_title: Transport kal'tsiia v éndoplazmaticheskom retikulume pecheni krys pri aktivatsii perekisnogo okisleniia lipidov.