Proliferative effects of epidermal growth factor on the intestinal epithelium of mice.
The effects of EGF on intestinal epithelial cell proliferation were studied in mice. Injection of 2 micrograms/kg/6h EGF in adult mice caused an increase of the crypt cell production rate in the duodenum and the colon as compared to the control mice. Doses tenfold higher of EGF evoked further significant crypt cell production rates. These results suggested that EGF could play an important role as a trophic factor in the maintenance of epithelial proliferation in the gastrointestinal tract.
Dyduch
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Silesian Pediatric Center, Silesian School of Medicine, Zabrze, Poland.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003106:Colon / Q000187:drug effects*; D004386:Duodenum / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000008:administration & dosage*; D008297:Male; D051379:Mice
D004815:Epidermal Growth Factor