The action of glucagon on gastric acid secretion and serum pepsinogen I.
In 39 patients the following were assessed: gastric acid secretion (mmol/hour), gastric juice volume (ml/hour), glycemia (mg%), and in 10 of them also pepsinogen I serum concentration (ng/ml). All these parameters were determined in basal conditions and after administration of glucagon. Glucagon induced achlorhydria in 33.3% of the patients, hypochlorhydria in 33.3%, did not influence HCl in 12.8%, and hyperchlorhydria in 20.5%. The gastric juice volume changed in parallel with chlorhydria. The HCl secretion did not correlate with the glycemia levels. Pepsinogen I was not significantly influenced by glucagon. It may be concluded that glucagon had a two-fold action on HCl secretion: (a) in two thirds of the patients studied it induced hypo- or achlorhydria; (b) in about 20% it induced hyperchlorhydria.
Andreica
V
V
3rd Medical Clinic, University of Medicine and Pharmacy, Cluf-Napoca, Romania.
Dumitraşcu
D
D
Mezei
E
E
Mureşan
L
L
D000126:Achlorhydria / Q000139:chemically induced; D000328:Adult; D000368:Aged; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005934:Glucagon / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*
D010435:Pepsinogens; D005934:Glucagon