[Long-term effects of indobufen on several parameters of blood platelet function in subjects at thrombotic risk].
Indobufen (200 mg b.i.d., by os, for 21 days) was gave to 16 patients with atherothrombotic risk in which platelet function was valued. In this subjects, indobufen significatively reduced platelet aggregation, beta-thromboglobulin, platelet factor the 4th and alpha-platelet granules' intake. No side effects were found.
Di Blasi
S
S
Cattedra di Medicina d'Urgenza, Università di Palermo.
Pintacuda
S
S
Ferotti
N
N
Lo Coco
L
L
Muratore
A
A
Russo
G
G
Di Blasi
U
U
D'Alessandro
M
M
Morici
G
G
Fornaciari
M
M
D000368:Aged; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors; D001620:beta-Thromboglobulin / Q000032:analysis
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; D001620:beta-Thromboglobulin; C020371:indobufen
Studio degli effetti a lungo termine dell'indobufene su alcuni parametri di funzione piastrinica in soggetti a rischio trombotico.