Study on thermostabilizers for trivalent oral poliomyelitis vaccine.
Different formulations of Trivalent Oral Poliomyelitis Vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs.
Leal
M L
ML
Fundação Oswaldo Cruz, Depro I, Rio de Janeiro, Brasil.
Lopes
F J
FJ
Carvalho
M H
MH
Moura
H A
HA
Soares
S A
SA
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D011055:Poliovirus Vaccine, Oral / Q000737:chemistry*; D012044:Regression Analysis; D013696:Temperature
D011055:Poliovirus Vaccine, Oral