Geometry and pump function in cardiac ventricular hypertrophy.
Ventricular pump function can be quantified by the inverse relation between pressure and output, i.e., the pump function graph, which is obtained by varying arterial load without changing end-diastolic volume, inotropic state and heart rate. The ratio of pressure and output, i.e., the peripheral resistance, can be represented in the same graph by a line through the origin. The 2 pressure-output relations intersect in the working point, i.e., the pressure and flow at the prevailing steady state. In normal, anesthetized cats the ventricle appears to be matched to the arterial load in the sense that the working point is found at the optimal power, i.e., the optimal value of the product of pressure and output along the pump function graph. To maintain this matching criterion during pressure overload, the ventricular volume has to remain the same while thickening of the wall takes place: concentric hypertrophy. With volume overload, matching would be preserved with eccentric hypertrophy. Because volume and pressure overloads typically lead to eccentric and concentric hypertrophy, respectively, the matching criterion may be a valuable predictor of the geometric changes found with changes in load. This idea was further investigated experimentally by determining the position of the working point in the perinephritic cat that had 1 kidney removed and the other wrapped in cellophane for 15 to 26 weeks. The working point was no longer found at the optimal power, indicating that either matching was permanently comprised or that the ventricle was still trying to restore matching.
Elzinga
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G
Laboratory for Physiology, Faculty of Medicine, Free University, Amsterdam, The Netherlands.
Toorop
G P
GP
Gross
D R
DR
Westerhof
N
N
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D006332:Cardiomegaly / Q000473:pathology* / Q000503:physiopathology; D002415:Cats; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles; D006977:Hypertension, Renal / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D009393:Nephritis / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology