title: Imipramine and weight gain during the treatment of recurrent depression.
abstract: Weight change was examined in 128 depressed outpatients treated successfully with an average dose of 215 mg imipramine and then continued on that treatment regimen for 5 additional months, an average duration of over 33 weeks. More than half the patients experienced a change in weight of 5% or less and only 13.3% experienced a gain of greater than 10%. While males and females did not differ in their pattern of change during acute treatment, females experienced a greater percent change (P less than 0.06) and change in body mass index (P = 0.05) during continuation treatment. The clinical implications of these findings are discussed, especially with respect to the extreme group.
authors: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
authors: E
authors: E
authors: Frank
authors: D J
authors: DJ
authors: Kupfer
authors: C M
authors: CM
authors: Bulik
authors: J A
authors: JA
authors: Levenson
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D012008:Recurrence; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D007099:Imipramine