An exact comparison between the efficiency of two- and three-cell-type clusters in mediating helper activity.
Adoptive transfer of anti-H-2Db-primed B cells combined with anti-minor histocompatibility antigen-primed T cells enables the effect of linked and unlinked alloantigen to be compared. Over an extensive dose range the unlinked antigen proved ineffective. In a previously described, exactly comparable system for assessing the same effect on cytotoxic T cell precursors, low doses of linked antigen had proved approximately equally effective, but high doses of unlinked antigen had proved effective. This contrast supports the hypothesis that whereas T-B collaboration is mediated by two-cell-type clusters, collaboration between T cells requires formation of three-cell-type clusters.
Mitchison
N A
NA
Tumour Immunology Unit, University College London, GB.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006183:H-2 Antigens / Q000276:immunology; D007116:Immunization, Passive; D066298:In Vitro Techniques; D008211:Lymphocyte Cooperation; D051379:Mice; D008912:Minor Histocompatibility Loci; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*
D006183:H-2 Antigens