The use of laboratory methods in contact dermatitis induced by composite materials.
Thin-layer chromatography, column chromatography, mass spectrometry and nuclear magnetic resonance were used to investigate the chemical constituents and haptens responsible in 2 different circumstances where allergic contact dermatitis from composite materials was suspected. In an aircraft factory where epoxy resins were used, tetraglycidyl-4,4'-dimethyl dianiline and phenylglycidyl ether were identified as the haptens responsible for an outbreak of contact dermatitis. The role of abietic acid as the main sensitizer in colophony was confirmed in a case of contact dermatitis occurring in a sportsman with an acute eczematous reaction due to a leg bandage. Identification of the chemical sensitizers was possible only by using the aforementioned laboratory methods.
Ayala
F
F
Clinica Dermatologica, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.
Lembo
G
G
Balato
N
N
Patruno
C
C
Scognamiglio
G
G
Strazzullo
G
G
de Stefano
S
S
D000293:Adolescent; D000814:Aniline Compounds / Q000009:adverse effects; D002851:Chromatography, High Pressure Liquid; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D004852:Epoxy Compounds / Q000009:adverse effects; D004853:Epoxy Resins / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000175:diagnosis / Q000209:etiology; D006229:Hand Dermatoses / Q000175:diagnosis / Q000209:etiology; D006241:Haptens / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010328:Patch Tests; D010647:Phenyl Ethers / Q000009:adverse effects
D000814:Aniline Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; D006241:Haptens; D010647:Phenyl Ethers; C042840:tetraglycidyl-4,4'-methylene dianiline; C016050:phenylglycidyl ether