A new screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis.
A novel screening method for melanin biosynthesis inhibitors using Streptomyces bikiniensis NRRL B-1049 as the indicator organism has been developed. Several known compounds, including tyrosinase inhibitors, were found to inhibit melanin production of S. bikiniensis on agar plates. This screening method was applied to fermentation broths of actinomycetes and several cultures with melanin biosynthesis inhibitory activity were found.
Tomita
K
K
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Oda
N
N
Ohbayashi
M
M
Kamei
H
H
Miyaki
T
T
Oki
T
T
D006639:Histidine / Q000031:analogs & derivatives / Q000494:pharmacology; D008543:Melanins / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000378:metabolism*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism; D013754:Tetracyclines / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014769:Virginiamycin / Q000494:pharmacology
D008543:Melanins; D013754:Tetracyclines; D014769:Virginiamycin; C067079:BU 3619E; D006639:Histidine; C013529:feldamycin; D014442:Monophenol Monooxygenase