title: Fiber exposure reassessed with the new indices.
abstract: The concentration of airborne fibers longer than 5 microns, thinner than 3 microns, and with an aspect ratio exceeding 3 as counted by phase contrast optical microscopy is the most widely used fiber exposure index. Recently, more adequate, specific exposure indices for asbestosis, lung cancer, and mesothelioma risk have been suggested by Lippmann (1988, Environ. Res., 46, 86-106). The consequences of using these indices are examined on the basis of calculations for a broad range of theoretical and published size distributions. Optical microscopy appears to be a good predictor of the exposure indices for asbestosis and for lung cancer after scaling. Only fibers longer than about 3 microns need to be counted in a transmission electron microscope. The lung cancer index still cannot explain the large differences of risk among chrysotile exposures. Both the mesothelioma exposure index and the ratio mesothelioma to lung cancer index ranks in order of increasing risk: wollastonite, glass and mineral wool, amosite, glass microfibers, chrysotile, and crocidolite. Amosite is thus not ranked according to epidemiological evidence. Detailed size information should be made available so that the size criteria can be adjusted. It may still prove necessary to use fiber type specific concentration limits.
authors: Danish National Institute of Occupational Health, Copenhagen.
authors: T
authors: T
authors: Schneider
authors: J
authors: J
authors: Skotte
mesh_terms: D001194:Asbestos / Q000032:analysis*; D017639:Asbestos, Amosite; D017638:Asbestos, Crocidolite; D017632:Asbestos, Serpentine; D001195:Asbestosis / Q000209:etiology; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology; D008654:Mesothelioma / Q000209:etiology; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D008903:Minerals / Q000032:analysis; D012307:Risk Factors
chemical_list: D017632:Asbestos, Serpentine; D008903:Minerals; D017638:Asbestos, Crocidolite; D017639:Asbestos, Amosite; D001194:Asbestos