title: Effects of immunomodulating therapy in systemic sclerosis.
abstract: We reviewed studies concerning immunomodulating therapy in systemic sclerosis. These comprise mostly uncontrolled trials and case reports. Some of these studies hint at a possible beneficial effect of antimetabolites (azathioprine, 5-fluoro-uracil and methotrexate), cyclosporine and interferon-gamma. However, to give a clearcut answer on the efficacy of these drugs in systemic sclerosis, controlled studies are urgently needed.
authors: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
authors: F H
authors: FH
authors: van den Hoogen
authors: A M
authors: AM
authors: Boerbooms
authors: L B
authors: LB
authors: van de Putte
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000477:Alkylating Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D000477:Alkylating Agents; D000963:Antimetabolites; D003524:Cyclosporins; D007371:Interferon-gamma