title: Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes.
abstract: Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.
authors: Center for Molecular Biology, University of Heidelberg, Germany.
authors: U
authors: U
authors: Mönning
authors: G
authors: G
authors: König
authors: R
authors: R
authors: Prior
authors: H
authors: H
authors: Mechler
authors: U
authors: U
authors: Schreiter-Gasser
authors: C L
authors: CL
authors: Masters
authors: K
authors: K
authors: Beyreuther
mesh_terms: D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor; D003208:Concanavalin A / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D009220:Myositis / Q000276:immunology / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D011498:Protein Precursors; D012333:RNA, Messenger; D003208:Concanavalin A