title: Effect of depot medroxyprogesterone acetate and testosterone oenanthate on serum lipoproteins in man.
abstract: Ten normal men were given three monthly intramuscular injections of 200mg of depot medroxyprogesterone acetate (DMPA) and 250mg of testosterone oenanthate (TE) as part of a male contraceptive trial. During the three months of treatment, serum high density lipoprotein cholesterol (HDL-C) and the HDL-C:LDL-C (low density lipoprotein cholesterol) ratio were significantly depressed compared to baseline. Although the long-term effect of this alteration in lipoprotein cholesterol metabolism in normolipidaemic men is currently uncertain, these results suggest that the potential cardiovascular risks of progestagen-containing regimens for male contraception will have to be seriously considered.
authors: MRC Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh, Scotland.
authors: E M
authors: EM
authors: Wallace
authors: F C
authors: FC
authors: Wu
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003272:Contraceptive Agents, Male; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives*; D017258:Medroxyprogesterone Acetate; D013739:Testosterone / Q000031:analogs & derivatives*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003272:Contraceptive Agents, Male; D008074:Lipoproteins; D013739:Testosterone; C004648:testosterone enanthate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone