Platelet scintigraphy and survival in juvenile stroke patients.
In the present study the prevalence of active atherosclerotic lesion sites in the carotid and femoral arteries as well as the platelet survival in a selected group of 33 patients (8 males, 25 females) below the age of 50 after juvenile stroke has been examined. In the patients studied a high frequency (80%) of positive (visible) carotid artery lesions with a platelet uptake ratio (PUR) ranging from 1.07-1.79 as well as an extremely shortened platelet survival were monitored. In-vitro platelet function tests, however, did not show significant abnormalities. No correlation between PUR, platelet survival, platelet function and the clinical situation could be assessed. These findings indicate that in this highly selected group of patients in-vivo haemostatic balancing seems to be severely impaired.
Pramsohler
B
B
Department of Neurology, Hospital Villach, Austria.
Lupattelli
G
G
Scholz
H
H
Sinzinger
H
H
D000328:Adult; D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D002470:Cell Survival; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D006487:Hemostasis; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D010979:Platelet Function Tests; D011877:Radionuclide Imaging; D012307:Risk Factors
D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline; D001241:Aspirin