[CA-125 serum level in early pregnancy follow hMG/hCG stimulated and unstimulated cycles].
The CA-125-antigen could not only be identified in the epithelium of serous ovarian carcinoma, but also in the regular surface epithelium of the endometrium, the decidua and the peritoneum. The aim of this study was, to examine the pattern of CA-125 in the serum of women at early stages of pregnancy, after hMG/hCG-stimulation and subsequent insemination, IVF or GIFT. In particular, it was differentiated between simple or twin pregnancies, ovarian hyperstimulation syndrome and mole pregnancies. 16 patients, who spontaneously became pregnant after cyclus-monitoring, served as a control group. Among the total of 77 patients, 16 women with single pregnancies without stimulation showed an increase of CA-125 values to maximum amounts of 42.9 +/- 18.8 U/ml in the 8th week. 21 patients with single pregnancies after hMG/hCG-treatment and IVF, exhibited maximums of 97.5 +/- 66.8 U/ml in the 6th week, in cases of twins (n = 10) of 216.8 +/- 85.1 U/ml in the 7th week. Considering the group with the hMG/hCG-stimulation and following insemination (n = 20), maximum values of 91.4 +/- 57.3 U/ml were found in the 6th week, just as in the IVF-group. In cases of ovarian hyperstimulation syndrome (n = 5) as well as in such of a mole pregnancy (n = 5), drastically elevated values of 9519 and 1496 U/ml respectively, have been demonstrated. The decidua is regarded as a presumable source of high antigen levels in normal pregnancy, while the peritoneum is assumed to be such as for the ovarian hyperstimulation syndrome. Concerning mole pregnancy, the antigen levels could possibly emerge from the amniotic fluid.(ABSTRACT TRUNCATED AT 250 WORDS)
Wilke
G
G
Frauenklinik und Hebammenlehranstalt, Georg-August-Universität Göttingen.
Hinney
B
B
Rath
W
W
Henze
C
C
Wuttke
W
W
Kuhn
W
W
D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000175:diagnosis; D007247:Infertility, Female / Q000097:blood* / Q000628:therapy; D008596:Menotropins / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011272:Pregnancy, Multiple / Q000097:blood; D011446:Prospective Studies; D011863:Radioimmunoassay; D012016:Reference Values; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D008596:Menotropins
CA-125-Serumspiegel in der Frühschwangerschaft nach hMG/hCG-stimulierten und nichtstimulierten Zyklen.