The cell adhesion molecule Cell-CAM 105 is an ecto-ATPase and a member of the immunoglobulin superfamily.
Cell-CAM 105 (C-CAM), a cell adhesion molecule in rat hepatocytes, was digested with trypsin, and peptides were isolated and sequenced by Edman degradation. The sequences of 4 peptides agreed with different regions of rat liver ecto-ATPase. Detailed biochemical analyses confirmed the identity between C-CAM and the ecto-ATPase. C-CAM/ecto-ATPase is a transmembrane protein having 4 immunoglobulin-like domains in the extracellular portion, demonstrating membership of the immunoglobulin superfamily. The ATPase activity suggests that ATP might influence cell adhesion, which would explain the inhibitory effect of exogenously added ATP on adhesion of several cell types.
Aurivillius
M
M
Department of Medical Cell Biology, Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden.
Hansen
O C
OC
Lazrek
M B
MB
Bock
E
E
Obrink
B
B
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D015815:Cell Adhesion Molecules / Q000302:isolation & purification / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D007136:Immunoglobulins; D008969:Molecular Sequence Data; D008970:Molecular Weight; D051381:Rats
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D000251:Adenosine Triphosphatases