Effect of isradipine, a new calcium antagonist on the lipid profile in patients with hypertension.
The effect of isradipine versus hydrocholorothiazide on the lipid profile of 44 hypertensive patients was investigated in a double-blind, randomized trial. Lipid profiles included total cholesterol, serum triglycerides, high density lipoprotein-cholesterol (HDL), HDL subclasses (HDL2 and HDL3), low density lipoprotein cholesterol (LDL), very low density lipoprotein cholesterol (VLDL), Apolipoprotein A-1 and Apolipoprotein B. Isradipine had no effect on the lipid profile in 52 week studies. Hydrochlorothiazide increased serum triglycerides in 11 of 13 patients by a mean of 8% for the group (p less than 0.05) in 52 week studies, and total cholesterol by a mean of 9 and 16% respectively (p less than 0.01) in 2 of 13 patients, with no difference in other lipid or lipoprotein parameters in short or long term experiments.
Samuel
P
P
Long Island Jewish Medical Center, New York.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001053:Apolipoproteins / Q000097:blood*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D000959:Antihypertensive Agents; D001053:Apolipoproteins; D002121:Calcium Channel Blockers; D008055:Lipids; D011725:Pyridines; D006852:Hydrochlorothiazide; D002784:Cholesterol; D017275:Isradipine