Growth and siderophore production by Bordetella pertussis under iron-restricted conditions.
It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin. Direct contact between B. pertussis and transferrin was not required as B. pertussis was able to acquire iron from transferrin when they were separated by a dialysis membrane. Siderophore activity was detected in supernatants from iron-restricted cultures of B. pertussis, B. bronchiseptica and B. parapertussis. Siderophores were identified as hydroxamates and were produced by both virulent and avirulent strains of B. pertussis.
Gorringe
A R
AR
Biologics Division, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, U.K.
Woods
G
G
Robinson
A
A
D001886:Bordetella pertussis / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology / Q000031:analogs & derivatives; D006877:Hydroxamic Acids / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000378:metabolism*; D033862:Iron-Binding Proteins; D017262:Siderophores; D014168:Transferrin / Q000378:metabolism / Q000494:pharmacology; D033863:Transferrin-Binding Proteins
D002352:Carrier Proteins; D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D033862:Iron-Binding Proteins; D017262:Siderophores; D014168:Transferrin; D033863:Transferrin-Binding Proteins; C026058:EDDA; D004492:Edetic Acid; D007501:Iron