title: Atriopeptin prevents angiotensin II-stimulated glucose utilization in the subfornical organ.
abstract: Previous studies have shown that angiotensin II (ANG II) increases glucose utilization in the subfornical organ and stimulates drinking behavior. We investigated with the deoxyglucose method whether atriopeptin III, an atrial natriuretic peptide (ANP), would prevent this enhanced glucose metabolism and interfere with the drinking response in the presence of ANG II. Two rat models with high circulating levels of ANG II were studied: the homozygous Brattleboro and ANG II-infused Sprague-Dawley rats. ANP decreased the normally enhanced glucose utilization in the subfornical organ in the Brattleboro rat and inhibited ANG II-stimulated glucose metabolism in the subfornical organ of Sprague-Dawley rats. This effect was accompanied by decreased ANG II-stimulated water intake. These findings indicate that ANP may act at the level of subfornical organ to antagonize the dipsogenic action of ANG II.
authors: Division of Neurosurgery, University of Texas Medical Branch, Galveston 77550.
authors: E
authors: E
authors: Nermo-Lindquist
authors: M
authors: M
authors: Kadekaro
authors: M L
authors: ML
authors: Terrell
authors: J
authors: J
authors: Nassar
authors: H
authors: H
authors: Lekan
authors: S
authors: S
authors: Freeman
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003919:Diabetes Insipidus / Q000235:genetics; D005947:Glucose / Q000378:metabolism*; D006720:Homozygote; D007262:Infusions, Intravenous; D008297:Male; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D013356:Subfornical Organ / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D005947:Glucose