Relationship between urinary excretion of sodium and dopamine in type 1 diabetic patients with an without microalbuminuria.
The relationship between urinary sodium and dopamine excretion was investigated in 40 normal males and in 48 normotensive, Type 1 diabetic males, 11 with microalbuminuria and 37 with normal albumin excretion. In all three groups a significant correlation was demonstrated and the regression lines were similar. Thus, no evidence was found that a defect in dopamine mobilization contributes to the early renal pathophysiological changes of Type 1 diabetes.
Patrick
A W
AW
Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, UK.
Jeffrey
R F
RF
Collier
A
A
Clarke
B F
BF
Lee
M R
MR
D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure; D015331:Cohort Studies; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology / Q000652:urine*; D003930:Diabetic Retinopathy / Q000652:urine; D004298:Dopamine / Q000652:urine*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D012016:Reference Values; D012044:Regression Analysis; D012964:Sodium / Q000652:urine*
D003404:Creatinine; D004298:Dopamine; D006442:Glycated Hemoglobin; D012964:Sodium