title: [Gonadal function in adolescents after total body irradiation in bone marrow transplantation].
abstract: Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.
authors: Clinica Pediatrica, Policlinico S. Matteo, Università di Pavia.
authors: D
authors: D
authors: Gambarana
authors: P
authors: P
authors: Tonani
authors: M
authors: M
authors: Bongiorno
authors: C
authors: C
authors: Focardi
authors: I
authors: I
authors: Biscaldi
authors: R M
authors: RM
authors: Cerbo
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010053:Ovary / Q000528:radiation effects*; D013737:Testis / Q000528:radiation effects*; D013739:Testosterone / Q000097:blood; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
vernacular_title: Studio della funzionalità gonadica in adolescenti sottoposti ad irradiazione totale corporea (TBI) per trapianto di midollo osseo (TMO).