[Achlorhydria, blood gastrin and normal gastric mucosa in high-altitude subjects].
According to current concepts, it is not feasible to associate achlorhydria with normal gastric mucosa. We have found in a group of high altitude dwellers, that it is possible to associate achlorhydria with normal gastric mucosa verified by endoscopic and histological studies. In this case, basal achlorhydria is associated with resistance to histamine stimulation and with high values of gastrinemia. The possibility of reduced parietal cell mass or the absence of gastrin and histamine receptors and of G-cell hyperfunction or hyperplasia, is discussed.
Jo
N
N
Instituto de Investigación Clínica, Facultad de Medicina Humana, UNMSM.
García
O
O
García
R
R
Jara
R
R
Woll
P
P
Jo
P
P
Carbajal
T
T
Losno
R
R
D000126:Achlorhydria / Q000175:diagnosis; D000328:Adult; D000531:Altitude; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000033:anatomy & histology*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male
D005755:Gastrins
Aclorhidria, gastrinemia y mucosa gástrica normal en sujetos de altura.