title: Binding specificity of Fusobacterium nucleatum to human erythrocytes, polymorphonuclear leukocytes, fibroblasts, and HeLa cells.
abstract: Eighteen strains of Fusobacterium nucleatum were studied with respect to their adherence to human erythrocytes, polymorphonuclear leukocytes, fibroblasts, and HeLa cells. Four types of adherence were found: 1) sugar-sensitive adherence 2) amino acid-sensitive adherence 3) unknown adherence 4) weak adherence. There was no obvious correlation between the patterns of hemagglutination and adherence to other cells. The results indicate not only a complex network of bacterial receptors on human cells, but also a variety of types of bacterial adherence as expressed by the selectivity of the bacterial binding to specific cell surfaces.
authors: Department of Microbiology, Hiroshima University School of Dentistry, Japan.
authors: M
authors: M
authors: Ozaki
authors: Y
authors: Y
authors: Miyake
authors: M
authors: M
authors: Shirakawa
authors: T
authors: T
authors: Takemoto
authors: H
authors: H
authors: Okamoto
authors: H
authors: H
authors: Suginaka
mesh_terms: D000116:Acetylgalactosamine / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D001773:Blood Cells / Q000502:physiology*; D004492:Edetic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology*; D005673:Fusobacterium / Q000502:physiology*; D005690:Galactose / Q000494:pharmacology; D006367:HeLa Cells / Q000502:physiology*; D006384:Hemagglutination / Q000187:drug effects; D006801:Humans; D007785:Lactose / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology; D011887:Raffinose / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D004492:Edetic Acid; D007785:Lactose; D000116:Acetylgalactosamine; D011887:Raffinose; D005690:Galactose