[Fluorouracil and high-dose folinic acid in the treatment of advanced colorectal carcinoma].
Forty-five consecutive patients with advanced colorectal cancer were treated with 5-fluorouracil and high dose folinic acid. Among 43 evaluable patients there were 7 objective responses for an overall response rate of 16%. Toxicity was generally mild and rapidly reversible. Compared to those reported with 5-fluorouracil alone, these results failed to demonstrate an increase in response rate in the treatment of advanced colorectal cancer with the combination of 5-fluorouracil and folinic acid.
Natali
M
M
Centro Oncologico Giorgio Porfiri, Latina.
D'Aprile
M
M
Tonini
G
G
Leggio
M
M
Vici
P
P
Carpano
S
S
Angelini
F
F
Carassai
A
A
Lopez
M
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013997:Time Factors
D002955:Leucovorin; D005472:Fluorouracil
Fluorouracile ed acido folinico ad alte dosi nel trattamento del carcinoma del colon-retto in fase avanzata.