Neuropharmacological actions of the superactive agonist analog D-TRP-6-LH-RH after peripheral injection into mice.
The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate and tail-flick tests, and decreased the open-field parameters (ambulation, rearing, grooming). The 100 and 1000 micrograms/kg doses increased the latencies of picrotoxin-induced seizures, significantly inhibited apomorphine-induced cage climbing and also exerted a cataleptogenic effect. The results indicate that this agonist analog of LH-RH has an inhibitory effect on the central nervous system, and the mechanism of its action may involve dopaminergic transmission and/or endogenous opiates.
Kádár
T
T
Department of Pathophysiology, A. Szent-Györgyi University Medical School, Szeged, Hungary.
Telegdy
G
G
Schally
A V
AV
D000698:Analgesia; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010147:Pain Measurement; D010852:Picrotoxin; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects; D017329:Triptorelin Pamoate
D001058:Apomorphine; D007987:Gonadotropin-Releasing Hormone; D010852:Picrotoxin; D017329:Triptorelin Pamoate