[Effects of procaterol on arterial blood gas and pulmonary function in asthmatic children].
We examined the changes in arterial blood gas, FEV1 and V50 after the inhalation of procaterol on 19 occasions in 16 asthmatic children. The initial value of PaO2 had statistically significant correlation with the initial values of %FEV1 and %V50. PaO2 fell down in 11 out of 19 (57.9%) and remarkably decreased more than 5 mmHg in 6 out of 19 (31.6%). The fall in PaO2 was most significant at 5 min after the inhalation in almost subjects. The changes in PaO2 after the inhalation had good correlation with the initial value of %FEV1 and %V50. The initial values were quite lower in the patients with decreased PaO2 more than 5 mmHg than those with increased PaO2. Severe patients showed statistically low values of the initial PaO2 and %V50 and showed a fall in PaO2 after inhalation compared with moderate patients. An increase in A-aDO2 elicited that deteriorations of V/Q ratio caused a decrease in PaO2 after inhalation. There were no significant changes in heart rates and no complaints of nausea, headache or tremor.
Obata
T
T
Department of Pediatrics, Tokyo Jikei University School of Medicine.
Masaki
T
T
Iikura
Y
Y
D000280:Administration, Inhalation; D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D017265:Procaterol; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects*
D001993:Bronchodilator Agents; D004983:Ethanolamines; D010100:Oxygen; D017265:Procaterol