title: Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP).
abstract: Alpha-human atrial natriuretic peptide (alpha-hANP) was synthesized by assembling six peptide fragments in solution followed by deprotection with HF and subsequent air-oxidation. The trimethylbenzyl group was employed as an S-protecting group of cysteine. The HF-dimethylselenide-m-cresol system was employed as a final deprotecting reagent and, at the same time, as a reducing reagent of Met(O). Synthetic alpha-hANP elicited potent diuretic and natriuretic activity in rats.
authors: Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
authors: M
authors: M
authors: Yoshida
authors: M
authors: M
authors: Shimokura
authors: Y
authors: Y
authors: Fujiwara
authors: T
authors: T
authors: Fujisaki
authors: K
authors: K
authors: Akaji
authors: Y
authors: Y
authors: Kiso
mesh_terms: D000595:Amino Acid Sequence; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D009320:Atrial Natriuretic Factor