Stratifying the patient at risk from coronary disease: new insights from the Framingham Heart Study.
Although cardiovascular disease remains the leading cause of death in the United States, cardiovascular disease mortality has decreased steadily during the past 2 decades. This trend is largely attributable to improved detection and management of cardiovascular risk factors, in which the Framingham Heart Study has played a major role. This article examines some of the risk factors associated with coronary heart disease, notably, advancing age, hypertension, left ventricular hypertrophy, smoking, elevated serum cholesterol, and reduced high-density lipoprotein, all of which have been investigated by the Framingham Heart Study. In addition, new data are presented from a multidimensional model of coronary heart disease. This is a novel approach that takes into account the interactions of multiple risk factors and their contribution to overall coronary heart disease risk.
Levy
D
D
Framingham Heart Study, MA 01701.
Wilson
P W
PW
Anderson
K M
KM
Castelli
W P
WP
D000328:Adult; D000367:Age Factors; D000465:Algorithms; D006332:Cardiomegaly / Q000150:complications; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
D002784:Cholesterol