title: Morphological findings in 70 kidneys of living donors for renal transplant.
abstract: Seventy donor kidneys for transplant were studied with light microscopy (LM), electron microscopy (EM) and immunofluorescence (IM) for C3, C4, Clq, IgG, IgA, IgE, IgM, and antifibrin; the samples were taken just before transplanting the allograft kidney. Glomerular changes were found in 35.7% of apparently normal living donors: 9 cases showed relative glomerular ischemia with an irregular basal membrane (12.9%); 5 cases showed a diffusely widened basal membrane without antecedents of hyperglycemia (7.1%); in one case (1.4%) there was a lesion similar to type 1 mesangio-capillary glomerulonephritis with C3++, IgG++, IgA+, and IgM+; in another case (1.4%) there were scant isolated C3 glomerular, subepithelial deposits with indentation of the basement membrane of the immunocomplex type with a microhematuria which was demonstrated only after donation, and in 9 cases (among them two pairs of siblings) there were mesangial IgA and mesangial electron-dense deposits compatible with Berger's disease (12.9%). None of these glomerulopathies were evident under LM.
authors: Escuela de Medicina, Departamento de Anatomía Patológica, Pontificia Universidad Católica de Chile, Santiago.
authors: H G
authors: HG
authors: Rosenberg
authors: P S
authors: PS
authors: Martínez
authors: A S
authors: AS
authors: Vaccarezza
authors: L V
authors: LV
authors: Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000378:metabolism; D005921:Glomerulonephritis / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000473:pathology; D007070:Immunoglobulin A / Q000378:metabolism; D007511:Ischemia / Q000473:pathology; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D007070:Immunoglobulin A