Changes in the number of mitochondrial genomes during human development.
Using a cDNA probe for the mitochondrially encoded third subunit of cytochrome c oxidase (COIII) we found a progressive increase in the number of mitochondrial DNA molecules in specific human tissues during normal fetal development. The data indicate that the tissue, rather than the final number of mitochondrial genomes, apparently plays a dominant role in determining the gestational stage at which the adult complement of this DNA is established.
Heerdt
B G
BG
Department of Oncology, Montefiore Medical Center, Bronx, New York.
Augenlicht
L H
LH
D015139:Blotting, Southern; D015342:DNA Probes; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics; D005314:Embryonic and Fetal Development; D015894:Genome, Human; D006801:Humans
D015342:DNA Probes; D004272:DNA, Mitochondrial; D003576:Electron Transport Complex IV