Telemetry of aortic pressure in unrestrained animals: validation of the method over a wide range of blood pressure (from 40 to 200 mmHg).
A telemetric method has been designed for continuous measurement of intra-arterial aortic blood pressure in the unrestrained dog. The system used a Konigsberg P7 transducer, a temperature-compensated voltage-controlled oscillator, an FM transmitter, and an FM tuner to convert the signal received into a voltage proportional to aortic blood pressure. The method was validated by comparison with a standard direct method (using cables for transmission). Over a wide range of blood pressure obtained by hypotensive and hypertensive drugs (in total about 2500 data points, ranging from 40 to 200 mmHg), the telemetric method gave almost the same result as the direct method. Absolute error (telemetric measure minus standard measure) was normally distributed, with a mean value of -0.44 mmHg, and a standard deviation of 3.37 mmHg. The telemetric method was designed for future studies on the chronobiology of blood pressure in normal condition, in stress conditions and under drugs.
Armentano
R
R
Favaloro Foundation, Buenos Aires, Agentina.
Cabrera-Fischer
E
E
Breitbart
G
G
Pichel
R
R
Levenson
J
J
Chau
N P
NP
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods*; D015924:Blood Pressure Monitors; D002317:Cardiovascular Agents / Q000494:pharmacology; D004285:Dogs; D013686:Telemetry / Q000379:methods
D000959:Antihypertensive Agents; D002317:Cardiovascular Agents