[Surface markers and function of T cells forming clusters with autologous dendritic cells].
Human peripheral dendritic cells form characteristic cell aggregates (clusters) with autologous T cells. We investigated the surface markers and function of the T cells that formed these clusters. The T cells that formed clusters were mainly CD4 positive, while CD8 positive cells were few. Moreover, the T cells that formed clusters were mostly 2H4 positive. However, some were 4B4 positive. These data showed that the T cells that formed clusters were mainly CD4 positive-2H4 positive cells. The function of the T cells that formed clusters was also investigated. These T cells significantly inhibited PWM-induced immunoglobulin production from autologous lymphocytes compared with non-clustered T cells. Or data indicated that the T cells that formed clusters were mainly suppressor-inducer T cells.
Imai
F
F
Second Department of Internal Medicine, Saitama Medical School.
Suzuki
T
T
Ishibashi
T
T
Akiyama
Y
Y
Katagiri
T
T
Dohi
Y
Y
D000954:Antigens, Surface / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000954:Antigens, Surface; D015704:CD4 Antigens