[Hydroxylation of debrisoquin in Parkinson's disease].
The accumulation of environmental substances, due to deficiency of liver detoxication processes, is one of the hypotheses put forward in the search of the cause of Parkinson's disease. The debrisoquine test was used to evaluate the capacity for hydroxylation of twenty patients treated for Parkinson's disease. No difference was found with the results obtained in non Parkinsonians: other metabolic pathways, notably S-methylation, should be explored.
Meillard
M N
MN
Laboratoire de Pharmacologie Clinique, Faculté de Médecine, Rennes.
Bentué-Ferrer
D
D
Brunet-Bourgin
F
F
Morel
G
G
Allain
H
H
D000328:Adult; D000368:Aged; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000652:urine; D012016:Reference Values
D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin
Etude de l'hydroxylation de la débrisoquine dans la maladie de Parkinson.