title: Familial protein S deficiency presenting as deep vein thrombosis occurring during pregnancy.
abstract: Subjects with congenital deficiency of protein S, a natural anticoagulant which serves as a co-factor for the antithrombotic activity of activated protein C, are at risk of thrombosis. We describe a family in which deep vein thrombosis-occurring during pregnancy in three members with abnormally low protein S activity - was the only manifestation of congenital heterozygous protein S deficiency. Early diagnosis and active treatment of protein S deficiency should be pursued in any woman with a family history of thrombosis, who is planning pregnancy.
authors: Servizio di Emostasi e Trombosi, IRCCS H. S. Raffaele, Milan, Italy.
authors: A
authors: A
authors: D'Angelo
authors: G
authors: G
authors: Mari
authors: P
authors: P
authors: Della Valle
authors: A
authors: A
authors: Marassi
authors: S V
authors: SV
authors: D'Angelo
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000172:deficiency* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000209:etiology*; D017293:Protein S; D013924:Thrombophlebitis / Q000209:etiology*
chemical_list: D006023:Glycoproteins; D017293:Protein S