Percentages and distributions of teicoplanin- and vancomycin-resistant strains among coagulase-negative staphylococci.
The activities of teicoplanin and vancomycin against 362 coagulase-negative staphylococci were determined by an agar dilution method. At the 4- and 32-micrograms/ml breakpoint levels of the National Committee for Clinical Laboratory Standards, 23.2% of the strains were intermediate and 1.7% were resistant to teicoplanin, in contrast to less than 0.3% intermediate to vancomycin. Resistant strains belonged to the species Staphylococcus epidermidis (74%) and S. haemolyticus (19%).
Goldstein
F W
FW
Laboratoire de Microbiologie Médicale, Hôpital Saint-Joseph, Paris, France.
Coutrot
A
A
Sieffer
A
A
Acar
J F
JF
D003030:Coagulase / Q000032:analysis*; D004352:Drug Resistance, Microbial; D006020:Glycopeptides / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology*
D003030:Coagulase; D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin; D008712:Methicillin