Concentration of phenoxymethylpenicillin in tonsillar tissue.
Seventeen patients underwent tonsillectomy 55-120 min after receiving oral phenoxymethylpenicillin 12.5 mg/kg bodyweight. The penicillin concentration in serum and tonsillar tissue in each patient was determined by a microbial assay. In 9 patients with tonsillar hyperplasia, but with no prior history of tonsillitis, the mean penicillin concentration in serum and in tonsillar tissue was 5.0 mg.l-1 and 1.32 mg.g-1, respectively, and in 8 patients with manifest tonsillitis the corresponding values were 3.01 mg.l-1 and 0.67 mg.g-1. It appears that the penicillin concentration in tonsillar tissue is about 1/5 to 1/4 of that in serum, regardless of whether the tonsils are inflamed or hypertrophied.
Roos
K
K
Department of ENT, Lundby Hospital, Göteborg, Sweden.
Brorson
J E
JE
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007958:Leukocyte Count; D014066:Palatine Tonsil / Q000737:chemistry*; D010404:Penicillin V / Q000032:analysis* / Q000097:blood; D014069:Tonsillitis / Q000188:drug therapy
D010404:Penicillin V