[Synaptic localization of 5'-nucleotidase activity in the cerebellar cortex in adult rats irradiated by X rays after birth].
5'-nucleotidase cytochemistry was performed in the cerebellum of adult rats exposed previously to a single postnatal X-irradiation which maintains until adulthood the normally transient multiple innervation of cerebellar Purkinje cells by climbing fibers. 5'-nucleotidase activity persists in climbing fiber synapses and other asymmetrical synapses while it is transient during normal development. Therefore, in the X-irradiated rat, an immature stage of the excitatory synapses persists which, for the climbing fibers, coïncides with or precedes their involution during normal development.
Bailly
Y
Y
Laboratoire de Neurobiologie du Développement, Institut des Neurosciences, C.N.R.S., Paris.
Schoen
S W
SW
Delhaye-Bouchaud
N
N
Kreutzberg
G W
GW
Mariani
J
J
D015720:5'-Nucleotidase / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002525:Cerebellar Cortex / Q000201:enzymology* / Q000528:radiation effects; D016371:Cranial Irradiation / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000201:enzymology*
D015720:5'-Nucleotidase
Localisation synaptique de l'actitivé 5'-nucléotidase dans le cortex cérébelleux du rat adulte irradié aux rayons X après la naissance.