Suppression of antral formation in the ovarian follicles of marmosets by human ovarian follicular fluid protein.
Ovarian follicular fluid peptide (OFFP) has earlier been shown to inhibit maturation of large follicles and ovulation in mice. An active fraction hGF2, obtained following partial purification from human ovarian follicular fluid, was injected at a dose of 20 micrograms to 4-month-old immature marmosets, every alternate day for 2 months. The animal were autopsied at 4 and 6 months of age. Ovarian morphology indicated the appearance of large follicles at 6 months of age in the control group. In contrast, in hGF2 treated marmosets development up to preantral follicles could be seen at 6 months. Furthermore, only in 1 out of the 3 treated marmosets, presence of large preantral follicles was observed and in the remaining 4 animals only primary and secondary follicles were noted. These results reveal that OFFP suppresses follicular development and antrum formation in marmosets.
Nándedkar
T D
TD
Department of Biology, Institute for Research in Reproduction, Bombay, India.
Shahid
J K
JK
Moodbidri
S B
SB
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002143:Callitrichinae; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D006080:Ovarian Follicle / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay
D010455:Peptides; D011374:Progesterone