Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone.
Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites.
Luo
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SQ
Department of Nutritional Sciences, University of Toronto, Ontario, Canada.
Ransom
T
T
Li
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ET
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000704:Analysis of Variance; D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; D005473:Fluoxetine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D002065:Buspirone