Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord.
Activation of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors is a critical step in the selection of appropriate synaptic connections in the developing visual systems of cat and frog. Activity-dependent development of mammalian motor neurons was shown to be similarly mediated by activation of the NMDA receptor. The expression of the Cat-301 proteoglycan on motor neurons was developmentally regulated and could be specifically inhibited by blockade of the NMDA receptor at the spinal segmental level. In the adult, Cat-301 immunoreactivity on motor neurons was not diminished by NMDA receptor blockade. The NMDA receptor may regulate the expression of a class of neuronal proteins (of which Cat-301 is one example) that underlie the morphological and physiological features of activity-dependent development.
Kalb
R G
RG
Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.
Hockfield
S
S
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000096:biosynthesis*; D000927:Anticonvulsants / Q000494:pharmacology; D006224:Cricetinae; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D011509:Proteoglycans / Q000096:biosynthesis*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000927:Anticonvulsants; D011509:Proteoglycans; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate