Translational control in influenza virus-infected cells.
Influenza virus type A has been shown to establish a translational control system such that during infection there is a dramatic inhibition of host cell protein synthesis and viral mRNAs are selectively and efficiently translated. The following review summarizes the complex strategies employed by influenza to accomplish these goals. These include: (i) preventing newly made cellular mRNAs from entering the cytoplasm of infected cells; (ii) inhibiting the initiation and elongation steps of translation of preexisting cellular mRNAs; (iii) possessing RNAs with structural features which enhance translation; (iv) encoding mechanisms to downregulate the interferon induced protein kinase thus allowing overall protein synthesis levels to remain high.
Katze
M G
MG
Department of Microbiology, School of Medicine, University of Washington, Seattle.
Krug
R M
RM
D000818:Animals; D001692:Biological Transport; D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics*; D007251:Influenza, Human / Q000235:genetics*; D010766:Phosphorylation; D014176:Protein Biosynthesis; D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger / Q000235:genetics*; D013347:Subcellular Fractions / Q000378:metabolism; D019892:eIF-2 Kinase
D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger; D019892:eIF-2 Kinase