Antithrombin III: structural and functional aspects.
Antithrombin III is a plasma glycoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 A resolution. The overall topology is similar to that of alpha 1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.
Mourey
L
L
Laboratoire de Cristallographie Biologique, IBMC du CNRS, Strasbourg, France.
Samama
J P
JP
Delarue
M
M
Choay
J
J
Lormeau
J C
JC
Petitou
M
M
Moras
D
D
D000595:Amino Acid Sequence; D000818:Animals; D000990:Antithrombin III / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction; D000515:alpha 1-Antitrypsin / Q000737:chemistry
D002241:Carbohydrates; D000515:alpha 1-Antitrypsin; D000990:Antithrombin III