[Influences of 3,4,5-trihydroxystibene-3-beta-mono-D-glucoside on rabbits' platelet aggregation and thromboxane B2 production in vitro].
Platelet aggregation and thromboxane B2 (TXB2) production induced by arachidonic acid (AA) or Adenosine diphosphate (ADP) were studied by turbidimetry and radioimmunoassay in rabbits. 3,4,5-tri-hydroxystibene-3-beta-mono-D-glucoside (PD) 6.7-107.2 mumol/L inhibited platelet aggregation and the production of TXB2 as well. The inhibitions by PD were dose-dependent: 48-90% (AA-induced) and 43-69% (ADP-induced) for platelet aggregation; 50-87% (AA-induced) and 43-68% (ADP-induced) for TXB2. There were positive correlations between the inhibition of platelet aggregation and production of TXB2.
Shan
C W
CW
Department of Pharmacology, First Military Medical College, Guangzhou, China.
Yang
S Q
SQ
He
H D
HD
Shao
S L
SL
Zhang
P W
PW
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005960:Glucosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013267:Stilbenes / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis*
D005960:Glucosides; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D013929:Thromboxane B2; C058229:polydatin