Expression of a neural cell adhesion molecule serum fragment is depressed in autism.
The level of a neural cell adhesion molecule (NCAM) serum fragment in autism was determined by using an antiserum prepared with immunoaffinity purified mouse NCAM. Autistic patients (N = 16) had statistically significantly decreased serum NCAM levels compared with age-matched controls (p less than 0.0005). This observation could not be attributed to a medication-induced effect. Depressed serum NCAM levels in autism are distinct from schizophrenia, in which serum NCAM levels are elevated.
Plioplys
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AV
Department of Pediatrics, University of Toronto.
Hemmens
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SE
Regan
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CM
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008297:Male; D012016:Reference Values
D015816:Cell Adhesion Molecules, Neuronal