title: Evaluation of circulating immune complexes in cutaneous diseases associated with immune disorders.
abstract: Several skin diseases associated with immune disorders may be related to the formation of circulating immune complexes (CIC) and their skin deposition. Sera from 20 controls and 108 patients, including: 23 psoriasis, 10 lichen planus, 30 atopic eczemas, 32 cases of leprosy, 10 vasculitis and 3 pyoderma gangrenosum were evaluated for the presence of IgG-containing CIC by the microconsumption complement test (MCT). Additionally, the presence of IgE-containing CIC by means of a polyethylene glycol precipitation and radioimmunoassay technique was evaluated in 10 patients with atopic eczema. It was found that 56.5% of psoriatic patients show moderate CIC concentrations, as well as 34% of leprosy patients, with increased levels when bacillus were detected in skin lesions, and in 90% of leukocytoclastic vasculitis. A close relationship between CIC levels and the clinical evolution of skin lesions was demonstrated in patients with pyoderma gangrenosum and lichen planus. IgG-CIC were detected in 33% and IgE-CIC in 30% of patients with atopic eczema, with the presence of both types of CIC in 2 out of 3 cases. The systematic research on CIC presence in some selected skin diseases shows that immune complexes take part, with different degrees of relevance, in the pathogenesis of all the entities.
authors: Department of Dermatology, Faculty of Medicine, University of Rosario, Argentina.
authors: R
authors: R
authors: Fernández Bussy
authors: C D
authors: CD
authors: Crisci
authors: G
authors: G
authors: Fiorenza
authors: N
authors: N
authors: Bertoya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002648:Child; D003876:Dermatitis, Atopic / Q000276:immunology; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007918:Leprosy / Q000276:immunology; D008010:Lichen Planus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology; D011711:Pyoderma / Q000276:immunology; D012871:Skin Diseases / Q000209:etiology / Q000276:immunology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007073:Immunoglobulin E