Mortality associated with ischaemic hepatitis.
Twenty-nine patients of 18,000 inpatient admissions over a six-month period developed ischaemic hepatitis accompanied by peak aspartate aminotransferase (AST-EC 2.6.1.1) activity greater than 1,000 U/L. Seventeen of these 29 patients died either during or shortly after the episode of ischaemic hepatitis, with an overall mortality of 58.6%. Mortality was not due in any of the cases to the hepatitis but rather the underlying cause. Ischaemic hepatitis was the commonest cause of an AST activity greater than 1,000 U/L in this hospital population (29 of 52 patients i.e. 56%). This condition is more common than generally appreciated and is associated with a poor prognosis.
Hickman
P E
PE
Department of Biochemistry, Royal Perth Hospital, WA.
Potter
J M
JM
D001219:Aspartate Aminotransferases / Q000097:blood* / Q000502:physiology; D002303:Cardiac Output, Low / Q000150:complications*; D002423:Cause of Death; D006505:Hepatitis / Q000097:blood / Q000209:etiology / Q000401:mortality*; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000209:etiology / Q000401:mortality*; D008099:Liver / Q000098:blood supply*; D011379:Prognosis
D001219:Aspartate Aminotransferases