[Immunopathogenesis of sarcoidosis: current practical knowledge].
Since the avenue of bronchoalveolar lavage detailed concepts of the immunopathogenesis of sarcoidosis have been developed. An alveolitis which parallels the inflammatory changes of the interstitium seems to be critical. Thus, the evaluation of the alveolitis yields information about the inflammatory processes in the interstitium. A compartmentalized activation of T-helper cells plays a central role in the maintenance and regulation of the alveolitis. Only the cells of the organs involved exhibit the features of activation, the cells of the peripheral blood are quiescent. By means of bronchoalveolar lavage the status of activation of the alveolar cells can be determined. Those parameters describe critical phenomenons of the disease. A detailed analysis of the activated alveolar cells disclosed mechanisms which generate serum parameters of clinical value.
Müller-Quernheim
J
J
Abteilung Innere Medizin mit Schwerpunkt Pneumologie, Johannes-Gutenberg-Universität Mainz.
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000276:immunology* / Q000473:pathology; D012507:Sarcoidosis / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
Die Immunpathogenese der Sarkoidose: aktuelles anwendbares Wissen.