Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.
1. Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. 2. Placental clearance for mannitol was 8.7 +/- 1.1 ml min-1 (mean +/- S.E.M.), lactulose 6.3 +/- 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/- 0.5, and inulin 0.98 +/- 0.1. 3. The permeability data were analysed in terms of restricted diffusion through 'notional' water-filled pores and found to be incompatible with a single population of uniform pores.
Bain
M D
MD
Clinical Research Centre, Harrow.
Copas
D K
DK
Taylor
A
A
Landon
M J
MJ
Stacey
T E
TE
D000328:Adult; D001724:Birth Weight; D002463:Cell Membrane Permeability / Q000502:physiology; D002585:Cesarean Section; D004492:Edetic Acid / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007444:Inulin / Q000493:pharmacokinetics; D007792:Lactulose / Q000493:pharmacokinetics; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics; D008970:Molecular Weight; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000378:metabolism*; D011247:Pregnancy
D008353:Mannitol; D007792:Lactulose; D007444:Inulin; D004492:Edetic Acid