title: Species differences in the generation of the chiral sulfoxide metabolite of albendazole in sheep and rats.
abstract: The prochiral anthelmintic drug albendazole was administered orally to sheep and rats. Blood samples were taken at standardized intervals during the time course of the plasma kinetics: 18 h in rats and 48 h in sheep. The enantiomeric ratio of the sulfoxide metabolite was determined by means of HPLC on a chiral stationary phase, the chiral selector of which was a N-3,5-dinitrobenzoyl derivative of (S)-tyrosine. Two enantiomers were detected in both animal species but their ratios were inverted in rat vs. sheep. The evolution of the ratio is turned from a racemate at 15 min to 60(-):40(+) at 12 h in rats, while it moved from 23(-):77(+) at 3 h to 4(-):96(+) at 36 h after administration in sheep.
authors: Department of Biochemistry, National School of Veterinary Medicine of Lyon, Marcy l'Etoile, France.
authors: P
authors: P
authors: Delatour
authors: E
authors: E
authors: Benoit
authors: M
authors: M
authors: Caude
authors: A
authors: A
authors: Tambute
mesh_terms: D015766:Albendazole / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008297:Male; D010599:Pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013047:Specific Pathogen-Free Organisms; D013237:Stereoisomerism; D013454:Sulfoxides / Q000097:blood*
chemical_list: D013454:Sulfoxides; D015766:Albendazole