In vitro testing method of polymers candidate destined for contact with blood.
Research aiming at obtaining athromobogenic biomaterials destined for contact with blood have been the subject of interdisciplinary studies carried out since 1980. When testing candidate materials, it is advisable that preliminary classification as well as elimination of materials not conforming to the requirements of athromobogenesis should be performed. Practicable laboratory methods were selected facilitating in vitro evaluation of materials of modified surface and conforming to the definite requirements. The testing of candidate materials of athromobogenic properties comprises basic research methods enabling instantaneous classification. The applied experimental model comprises the following: scanning electron microscopy (SEM), thromboelastography (TEG), formula: [see text] examining clotting systems by determining calcium, cephalincalcium times as well as the amount of blood platelets, biochemical examination. Application of the above-mentioned methods enables objective preliminary evaluation of candidate materials that may be applied in obtaining implantation products and medical appliances for the contact with blood.
Szymonowicz
M
M
Department of Experimental Surgery and Biomaterials, Research Medical Academy, Wrocław.
Lowkis
B
B
D001769:Blood / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests; D005343:Fibrinolytic Agents; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates / Q000494:pharmacology; D011095:Polyethylenes / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*; D011143:Polyvinyl Chloride / Q000494:pharmacology; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D011093:Polyethylene Terephthalates; D011095:Polyethylenes; D011108:Polymers; D011143:Polyvinyl Chloride