title: Formation of carbonate-apatite crystals after implantation of calcium phosphate ceramics.
abstract: The aims of this study were (1) to determine at the crystal level, the nonspecific biological fate of different types of calcium phosphate (Ca-P) ceramics after implantation in various sites (osseous and nonosseous) in animals and (2) to investigate the crystallographic association of newly formed apatitic crystals with the Ca-P ceramics. Noncommercial Ca-P ceramics identified by X-ray diffraction as calcium hydroxylapatite (HA), beta-tricalcium phosphate (beta-TCP), and biphasic calcium phosphates (BCP) (consisting of beta-TCP/HA = 40/60) were implanted under the skin in connective tissue, in femoral lamellar cortical bone, articular spine bone, and cortical mandibular and mastoidal bones of animals (mice, rabbits, beagle dogs) for 3 weeks to 11 months. In humans, HA or beta-TCP granules were used to fill periodontal pockets, and biopsies of the implanted materials were recovered after 2 and 12 months.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: U225 INSERM, Unite de Recherche sur les Tissus Calcifies, Nantes, France.
authors: G
authors: G
authors: Daculsi
authors: R Z
authors: RZ
authors: LeGeros
authors: M
authors: M
authors: Heughebaert
authors: I
authors: I
authors: Barbieux
mesh_terms: D000818:Animals; D002130:Calcium Phosphates; D002516:Ceramics; D003460:Crystallization; D004285:Dogs; D017886:Durapatite; D006882:Hydroxyapatites; D051379:Mice; D008854:Microscopy, Electron; D019736:Prostheses and Implants; D011817:Rabbits; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous