Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8, and alpha beta T cell receptor molecules.
We have been able to establish stable, minor histocompatibility antigen-specific, non-cytolytic, MHC-class II-restricted suppressor T cell clones and lines. These suppressor T cells rearrange, transcribe, and express alpha beta T cell receptor. An unusual feature of all our clones and lines is the co-expression of CD4 and CD8 molecules on their cell surface, a characteristic which may distinguish them from conventional helper and cytolytic T cells in this system. The fact that multiple, phenotypically and functionally identical cell lines were reproducibly obtained from this system indicates that antigen-specific down-regulation of immune functions in certain circumstances is mediated by T cells that are neither conventional cytolytic nor helper T cells.
Nanda
N K
NK
ICRF Tumour Immunology Unit, University College London, UK.
Thomson
E
E
Mason
I
I
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D002460:Cell Line; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D015329:Gene Rearrangement, T-Lymphocyte; D000949:Histocompatibility Antigens Class II; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014158:Transcription, Genetic
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta