title: Persistent hyperactivity of the parathyroid glands in treated hypothyroid patients.
abstract: Twelve untreated hypothyroid patients were submitted to EDTA infusion and the parathyroid hormone response to the induced hypocalcemia was studied with an amino-terminal specific assay. Eight of these patients were retested 6 months after achieving clinical and laboratory euthyroidism. The PTH response in the pretreatment condition was significantly higher than that obtained in a group of 10 normal individuals; this increased response had not normalized after 6 months of euthyroidism. This persisting hyperresponsiveness can be a contributory factor to the bone hypersensitivity to thyroid hormone replacement seen in hypothyroid patients.
authors: Division of Endocrinology, Escola Paulista de Medicina, São Paulo, Brazil.
authors: R P
authors: RP
authors: Furlanetto
authors: M L
authors: ML
authors: Castro
authors: T S
authors: TS
authors: Kasamatsu
authors: C M
authors: CM
authors: Brandãno
authors: J G
authors: JG
authors: Vieira
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D004492:Edetic Acid; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D010281:Parathyroid Hormone; D004492:Edetic Acid; D013974:Thyroxine; D002118:Calcium