Impact of smoking, physical training and weight reduction on FVII, PAI-1 and hemostatic markers in sedentary men.
The variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers, who were admitted to a 6 months' program of physical training and smoking cessation. After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month period could maintain normal FVII and PAI-1 activities but participants who stopped the training increased their FVII and PAI-1 plasma levels. FVII was not influenced by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were correlated and the weight reduction induced by training was related to the changes in the factors. In smokers, physical exercise was associated with a significant increase of hemostatic markers. This exercise-induced variation disappeared after 3 months of intervention in participants who stopped smoking and reappeared in those who smoked again after 6 months of intervention. This finding was not influenced by the physical training program.
Gris
J C
JC
Laboratoire d'Hématologie et Immunologie, Centre Hospitalier Gaston Doumergue, Nîmes, France.
Schved
J F
JF
Feugeas
O
O
Aguilar-Martinez
P
P
Arnaud
A
A
Sanchez
N
N
Sarlat
C
C
D000990:Antithrombin III / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D005167:Factor VII / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005344:Fibrinopeptide A / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D010806:Physical Education and Training; D015849:Plasminogen Inactivators / Q000097:blood; D015203:Reproducibility of Results; D012907:Smoking / Q000097:blood*; D015431:Weight Loss / Q000502:physiology*; D001620:beta-Thromboglobulin / Q000378:metabolism
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D015849:Plasminogen Inactivators; C046193:antithrombin III-protease complex; D001620:beta-Thromboglobulin; C036309:fibrin fragment D; D005344:Fibrinopeptide A; D000990:Antithrombin III; D005167:Factor VII; D010447:Peptide Hydrolases