Isolation and characterization of a high molecular weight lymphocyte Fc gamma receptor-blocking factor associated with renal allograft survival.
We have confirmed our previous observation that improved human renal allograft survival is associated with the presence in pre-transplant serum of a high molecular weight lymphocyte Fc gamma receptor-blocking factor. Serum fractionation studies suggest that this factor is a complex protein consisting of IgG together with an IgG-binding protein which has an apparent molecular weight of approximately 60 kD.
Sandilands
G P
GP
University Department of Pathology, Western Infirmary, Glasgow, Scotland.
Cocker
J E
JE
McMillan
M A
MA
Owsianka
A M
AM
Marsden
H
H
Junor
B J
BJ
Briggs
J D
JD
MacSween
R N
RN
D000943:Antigens, Differentiation / Q000276:immunology*; D001685:Biological Factors / Q000276:immunology* / Q000302:isolation & purification; D002499:Centrifugation, Density Gradient; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000302:isolation & purification; D016030:Kidney Transplantation / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology / Q000302:isolation & purification; D008297:Male; D008970:Molecular Weight; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG; D012397:Rosette Formation
D000943:Antigens, Differentiation; D001685:Biological Factors; D007074:Immunoglobulin G; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D011961:Receptors, Fc; D017452:Receptors, IgG; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors