Blood oxygen parameters in patients with chronic obstructive pulmonary disease. An evaluation of measured and calculated 2,3-diphosphoglycerate concentrations.
48 simultaneous arterial and venous blood samples from 15 patients with chronic obstructive pulmonary disease (COPD) were evaluated for calculated p50 and measured and calculated 2,3-diphosphoglycerate (DPG) concentration. 23 samples (48%) demonstrated a leftward shift in the calculated in vivo p50, whereas both measured and calculated DPG showed 5% below and 28% above reference range. Measured DPG was significantly higher than calculated DPG in the leftshifted group, whereas there was no significant difference in the non-leftshifted group. Mean arterial pH was alkalotic in the leftshifted group and significantly higher than mean pH in the non-leftshifted group. It is concluded that DPG concentration cannot be calculated by the algorithm in patients with COPD and a leftward shift in the oxygen dissociation curve.
Nielsen
C
C
Department of Respiratory Medicine, Aalborg Hospital, Denmark.
Hindsholm
K B
KB
Nielsen
E M
EM
Dahl
B
B
D019794:2,3-Diphosphoglycerate; D001158:Arteries; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008433:Mathematics; D010100:Oxygen / Q000097:blood*; D014680:Veins
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D002245:Carbon Dioxide; D010100:Oxygen