title: Cyclic oxygen analogues of alkyl-lysophospholipids. Synthesis and neoplastic cell growth inhibitory properties.
abstract: Ether phospholipids have demonstrated both in vitro and in vivo activity against a wide variety of tumor cell lines. The known cyclic ether phospholipid, SRI 62-834, was used as the model to prepare eight novel phospholipids containing a cyclic ether. All of the compounds were as effective as ET-18-OCH3 in their ability to activate macrophage-induced cytotoxicity against the Abelson-8.1 tumor cell line but varied in their direct cytotoxic effects. One of the new compounds, SDZ 62-406, was selected for in vivo studies and showed oral and i.v. activity in the mouse MethA fibrosarcoma model in the same range as ET-18-OCH3. No correlation was found between the direct or macrophage-activated cytotoxicity and the ability of the compounds to inhibit or promote platelet-activating factor (PAF)-induced aggregation of human platelets.
authors: Sandoz Research Institute, East Hanover, NJ 07936.
authors: W J
authors: WJ
authors: Houlihan
authors: M L
authors: ML
authors: Lee
authors: P G
authors: PG
authors: Munder
authors: C M
authors: CM
authors: Winslow
authors: S H
authors: SH
authors: Cheon
authors: F J
authors: FJ
authors: D'Aries
authors: A K
authors: AK
authors: DeLillo
authors: C S
authors: CS
authors: Jaeggi
authors: R B
authors: RB
authors: Mason
authors: V A
authors: VA
authors: Parrino
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D010742:Phospholipid Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D012513:Sarcoma, Experimental / Q000188:drug therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010742:Phospholipid Ethers; C072627:SDZ 62-406; C026659:edelfosine