title: T lymphocyte subpopulations in leprosy patients and their relation with circulating immune complexes.
abstract: The possible relationship between circulating immune complexes (CIC) and peripheral T lymphocyte populations was studied in thirteen active multibacillary leprosy (10 lepromatous--LL--and 3 borderline lepromatous--BL--) and 19 matched controls. Theophylline-resistant T cells (The-R, a lymphocyte subpopulation displaying helper activity on B cells) and total T cells were assessed by means of the E rosette technique, with and without previous theophylline incubation, 1h 37 degrees C, respectively. CIC were quantified by 125I-C1q binding test. Although leprosy patients showed a statistical non significant light depression in total T cells the remarkable variability in circulating levels of The-R T cells enabled us to separate them into two well delineated groups (in relation to this variable p less than 0.001) with no difference in age, sex and bacteriologic state: a) leprosy patients with The-R T cells proportionally conserved (6LL and 2BL); b) leprosy patients with The-R T cells proportionally depressed (4LL and 1BL). Patients belonging to the latter group showed the highest statistically significant levels of CIC. Even though we do not discard an unknown factor being responsible for our findings, we believe that this inverse relationship between elevated CIC and depressed The-R circulating T cells might be representing a lower helper activity on antibody synthesis intending to reduce its excessive production.
authors: División Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
authors: O A
authors: OA
authors: Bottasso
authors: J C
authors: JC
authors: Morini
authors: G
authors: G
authors: Ramos
authors: A
authors: A
authors: Segal-Eiras
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis; D005260:Female; D006801:Humans; D015439:Leprosy, Borderline / Q000276:immunology* / Q000473:pathology; D015440:Leprosy, Lepromatous / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc / Q000032:analysis; D017452:Receptors, IgG; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D013806:Theophylline / Q000494:pharmacology
chemical_list: D000936:Antigen-Antibody Complex; D000943:Antigens, Differentiation; D011961:Receptors, Fc; D017452:Receptors, IgG; C035311:immunoglobulin M receptor; D013806:Theophylline