Protective effect of cinnarizine against convulsive elevation of nonesterified fatty acids in CNS.
In the brain tissue there exists a highly active "pool" of nonesterified fatty acids (NEFA). The greatest part of NEFA comes from the fraction of nerve endings. It was evidenced that the model convulsive activity provoked by Bemegrid increased NEFA in the brain cortex, hypothalamus and brain stem. Cinnarizine (StugeronR) markedly decreases the convulsive increase of NEFA. The greatest inhibitory effect was observed in the brain cortex. Cinnarizine has an objective stabilizing and anticonvulsive effect on the brain tissue.
Sklenovský
A
A
Department of Pathological Physiology, Medical Faculty of the Palacký University, Olomouc, Czechoslovakia.
Navrátil
J
J
Chmela
Z
Z
D000818:Animals; D001534:Bemegride; D001921:Brain / Q000378:metabolism*; D002936:Cinnarizine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D002936:Cinnarizine; D001534:Bemegride