title: A plasmid-encoded anion-translocating ATPase.
abstract: An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.
authors: Department of Biochemistry, Wayne State University, School of Medicine, Detroit, MI 48201.
authors: B P
authors: BP
authors: Rosen
authors: C M
authors: CM
authors: Hsu
authors: C E
authors: CE
authors: Karkaria
authors: P
authors: P
authors: Kaur
authors: J B
authors: JB
authors: Owolabi
authors: L S
authors: LS
authors: Tisa
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics*; D053501:Arsenite Transporting ATPases; D004926:Escherichia coli / Q000235:genetics; D016623:Ion Pumps; D009097:Multienzyme Complexes; D009876:Operon; D010957:Plasmids / Q000235:genetics*
chemical_list: D016623:Ion Pumps; D009097:Multienzyme Complexes; D000251:Adenosine Triphosphatases; D053501:Arsenite Transporting ATPases