gamma delta T-cell receptor-positive T-cell clones derived from human heart transplants do not show donor-specific cytotoxicity.
gamma delta T-cell receptor-positive T-cell clones were obtained from three endomyocardial biopsies taken from two patients. Clones obtained from two biopsies from patient A, one taken during rejection and one after resolution of this rejection, were WT31-, 11F2+, Ti gamma A-, delta TcS1+. Clones from patient B grown from a biopsy without histologic signs of rejection were either WT31-, 11F2+, Ti gamma A+, delta TcS1-, or WT31+. All gamma delta T-cell receptor-positive clones had cytolytic potential but did not demonstrate donor-specific lysis.
Jutte
N H
NH
Department of Internal Medicine I, Erasmus University Rotterdam, The Netherlands.
Vandekerckhove
B A
BA
Vaessen
L M
LM
Ouwehand
A J
AJ
Baan
C C
CC
Bos
E
E
Claas
F H
FH
Weimar
W
W
D001706:Biopsy; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D009206:Myocardium / Q000166:cytology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta