Acute T-lymphocytic leukemia with Ph1 and 5q-chromosome abnormalities and rearrangements of bcr and TCR-delta genes.
Almost all cases of Ph1-positive acute lymphocytic leukemia (ALL) have an immature B-cell phenotype and are CD10-positive. A very rare case of Ph1-positive ALL with T-cell features (T-ALL) is presented. Cytogenetic analyses revealed a clone with a Ph1 chromosome and 5q- at diagnosis, and mosaic clones with an additional complex abnormal karyotype at relapse. DNA analysis revealed rearrangement of the breakpoint cluster region (bcr) gene with deletion of the 5' side and of the T-cell receptor (TCR) delta gene, without any rearrangement of other immune-associated genes. From the results of immunophenotypic and genetic analyses, the origin of leukemic cells seemed to be an immature T-cell at a very early stage on T-cell ontogeny.
Takechi
M
M
Department of Hematology, Hiroshima University, Japan.
Ohnishi
A
A
Tanaka
K
K
Kimura
N
N
Kamada
N
N
D002872:Chromosome Deletion; D002873:Chromosome Fragility; D002895:Chromosomes, Human, Pair 5; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D010677:Philadelphia Chromosome; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta
D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta