title: Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.
abstract: 1. Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. 2. Placental clearance for mannitol was 8.7 +/- 1.1 ml min-1 (mean +/- S.E.M.), lactulose 6.3 +/- 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/- 0.5, and inulin 0.98 +/- 0.1. 3. The permeability data were analysed in terms of restricted diffusion through 'notional' water-filled pores and found to be incompatible with a single population of uniform pores.
authors: Clinical Research Centre, Harrow.
authors: M D
authors: MD
authors: Bain
authors: D K
authors: DK
authors: Copas
authors: A
authors: A
authors: Taylor
authors: M J
authors: MJ
authors: Landon
authors: T E
authors: TE
authors: Stacey
mesh_terms: D000328:Adult; D001724:Birth Weight; D002463:Cell Membrane Permeability / Q000502:physiology; D002585:Cesarean Section; D004492:Edetic Acid / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007444:Inulin / Q000493:pharmacokinetics; D007792:Lactulose / Q000493:pharmacokinetics; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics; D008970:Molecular Weight; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D008353:Mannitol; D007792:Lactulose; D007444:Inulin; D004492:Edetic Acid