Influence of local injection of 5,7-DHT and 6-OH-DA into the neocortex on learning and exploratory behavior of rats in the open field.
The features of the exploratory behavior in the open field, of the learning of a conditioned-reflex food-procuring reaction, and of the shift in the level of biogenic amines of the brain was studied in Wistar rats with local injections of the specific neurotoxins 6-hydroxydopamine (6-OH-DA) and 5,7-dihydroxytryptamine (5,7-DHT). It was shown that damage to the structure of the serotoninergic or catecholaminergic systems of the frontal cortex and hippocampus caused by local injection of 6-OH-DA and 5,7-DHT into the neocortex is accompanied by multidirectional changes in the exploratory behavior and learning of the animals.
Ismailova
Kh Yu
KhY
Laboratory of Neurophysiology of Integrative Brain Activity, A. I. Karaev Institute of Physiology, SSR, Baku.
Gasanov
G G
GG
Semenova
T P
TP
Bobkova
N V
NV
Nesterova
I V
IV
Gromova
E A
EA
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology; D005106:Exploratory Behavior / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D007858:Learning / Q000187:drug effects*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D009411:Nerve Endings / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology
D001679:Biogenic Amines; D002395:Catecholamines; D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D016627:Oxidopamine