title: Etiology of infection and morphologic changes in the lungs of Filipino children who die of pneumonia.
abstract: Histopathologic studies and isolation of virus and bacteria in culture were carried out for 71 children less than 5 years of age with fatal pneumonia. A potential microbial etiology was identified for 61 children (86%): bacteria for 19 (27%), virus for 16 (23%), and virus plus bacteria for 26 (37%). Staphylococcus was the most prevalent pathogen, alone or in combination with other organisms, followed by Pseudomonas aeruginosa. Viral infection may predispose to bacterial infection in some children. A correlation of clinical course, results of cultures, and morphologic changes revealed cofactors that may have contributed to a fatal outcome. Lung abscess, pericarditis, myocarditis, endocarditis, and meningitis were associated with bacterial infection. Many patients in this study had severe bronchopneumonia, with a high prevalence of complications such as abscess (62%), atelectasis (40%), pericarditis (28%), and empyema (7%). Such complications added to multiple infections, measles, and malnutrition contributed to the fatal outcome in these children.
authors: Research Institute for Tropical Medicine, Department of Health, Manila, Philippines.
authors: N C
authors: NC
authors: Gonzaga
authors: E E
authors: EE
authors: Navarro
authors: M G
authors: MG
authors: Lucero
authors: S C
authors: SC
authors: Queipo
authors: I
authors: I
authors: Schroeder
authors: T E
authors: TE
authors: Tupasi
mesh_terms: D000367:Age Factors; D000402:Airway Obstruction / Q000473:pathology; D001424:Bacterial Infections / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D001980:Bronchi / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008169:Lung Abscess / Q000382:microbiology; D008297:Male; D008679:Metaplasia; D009336:Necrosis; D010996:Pleural Effusion / Q000473:pathology; D011014:Pneumonia / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D011552:Pseudomonas Infections / Q000209:etiology / Q000401:mortality / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D018805:Sepsis / Q000382:microbiology; D013203:Staphylococcal Infections / Q000209:etiology / Q000401:mortality / Q000473:pathology; D014777:Virus Diseases / Q000209:etiology / Q000401:mortality* / Q000473:pathology