A case of malignant histiocytosis successfully treated with combination interferon and etoposide therapy.
A 66-year-old woman with malignant histiocytosis was treated with a combination of recombinant gamma interferon (GI-3) and etoposide. Following partial response to intravenous gamma interferon (9 x 10(6) units (U)/day) alone, the patient received an eight-months course of subcutaneous gamma interferon (0.5 x 10(6) U/day) and intravenous etoposide (100 mg/week). After two years, the patient remains in complete remission. The present case report discusses the successful use of combination gamma interferon and etoposide for the treatment of malignant histiocytosis.
Takemori
H
H
First Department of Internal Medicine, Hirosaki University School of Medicine.
Sakata
Y
Y
Suzuki
H
H
Yamaya
T
T
Furugori
N
N
Morimoto
S
S
Yoshida
Y
Y
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage* / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D005047:Etoposide; D007371:Interferon-gamma