[The etiopathogenesis of the acute stress ulcer. The role of oxygen free radicals].
We evaluated the role of oxygen free radicals in the induction of acute stress gastric ulcer in rats. After 12 hr of immobility, ulcers of up to 4 mm were observed in the gastric mucosa. Pretreatment with allopurinol, a xanthine oxidase inhibitor, produced a significant reduction in the number and size of lesions (p < 0.0001). No protection was afforded by aluminum hydroxide or ranitidine alone, but enhanced protection was observed when given in association to allopurinol. A secondary role for H ions is suggested by these findings. Our results support the hypothesis of a role of oxygen free radicals in the pathogenesis of stress gastric ulcers. Allopurinol might be used in conditions predisposing to stress in patients.
Mancinelli
S
S
Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.
de la Fuente
G
G
Manríquez
V
V
Aracena
M
M
Múñoz
R
R
Mancinelli
S
S
Múñoz
S
S
D000208:Acute Disease; D000493:Allopurinol / Q000627:therapeutic use; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005609:Free Radicals; D008297:Male; D010101:Oxygen Consumption; D011899:Ranitidine / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D013312:Stress, Physiological / Q000150:complications* / Q000378:metabolism / Q000517:prevention & control
D005609:Free Radicals; D000536:Aluminum Hydroxide; D000493:Allopurinol; D011899:Ranitidine
Etiopatogenia de la úlcera aguda por estrés. Rol de los oxidantes derivados del oxígeno.