title: Chronic antidepressant and clonidine treatment effects on conflict behavior in the rat.
abstract: The present studies examined the effects of chronic treatment with several antidepressants and clonidine on conflict behavior. In daily ten-minute sessions, water-deprived rats were trained to drink from a tube which was occasionally electrified (0.25 or 0.5 mA). Electrification was signalled by a tone. Chronic desipramine (5 mg/kg, IP, b.i.d.) or clonidine (40 micrograms/kg, b.i.d.) treatment resulted in time-dependent anticonflict effects, with a latency to onset of approximately 3-4 weeks. In contrast, chronic buproprion (up to 10 mg/kg, IP, b.i.d.), mianserin (up to 10 mg/kg, IP, b.i.d.) or trazodone (up to 40 mg/kg, IP, b.i.d.) treatment resulted in at best only a weak anticonflict effect. The efficacy of these antidepressants and clonidine to increase punished responding when administered chronically correlates well with their efficacy as antipanic agents in man.
authors: Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, Wayne State University, Detroit, MI 48202.
authors: R L
authors: RL
authors: Commissaris
authors: D M
authors: DM
authors: Ellis
authors: T J
authors: TJ
authors: Hill
authors: D M
authors: DM
authors: Schefke
authors: C A
authors: CA
authors: Becker
authors: D J
authors: DJ
authors: Fontana
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D016642:Bupropion; D003000:Clonidine / Q000494:pharmacology*; D003220:Conflict, Psychological; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D008803:Mianserin / Q000494:pharmacology; D010200:Panic / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014196:Trazodone / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion; D008803:Mianserin; D003000:Clonidine; D003891:Desipramine; D014196:Trazodone