Cleavage of zearalenone-glycoside, a "masked" mycotoxin, during digestion in swine.
Comparative analyses of cereal samples pretreated with or without beta-glucosidase indicate the presence of zearalenone-glycoside. To examine the stability of zearalenone-glycoside during digestion, mixed feed was artificially contaminated with synthesized zearalenone-4-beta-D-glucopyranoside (395 micrograms/kg) and fed to a pig over a period of 14 days. The metabolites detected in feces and urine samples were zearalenone and alpha-zearalenol. These results demonstrate that zearalenone-4-beta-D-glucopyranoside is decomposed during digestion and the aglucone, zearalenone, is released. Since zearalenone-glycoside is not detected during routine analysis, but hydrolysed during digestion, it seems likely that such "masked mycotoxins" are involved in cases of mycotoxicoses.
Gareis
M
M
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, University of Munich.
Bauer
J
J
Thiem
J
J
Plank
G
G
Grabley
S
S
Gedek
B
B
D000821:Animal Feed; D000818:Animals; D004063:Digestion; D005260:Female; D005506:Food Contamination; D005960:Glucosides / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism*; D006868:Hydrolysis; D009183:Mycotoxins / Q000378:metabolism*; D012118:Resorcinols / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*; D015025:Zearalenone / Q000031:analogs & derivatives / Q000378:metabolism*
D005960:Glucosides; D006027:Glycosides; D009183:Mycotoxins; D012118:Resorcinols; C050324:zearalenone-4-glucopyranoside; D015025:Zearalenone