title: The American lung fluke, Paragonimus kellicotti, in a cat model.
abstract: Twenty-four specific-pathogen-free domestic cats were infected orally with from 2 to 30 Paragonimus kellicotti metacercariae and followed for 2-61 wk. Following infection by metacercarial cysts dissected from crayfish, the lungs of the cats undergo changes of intense eosinophilic pneumonia, granulomatous pneumonitis, squamous epithelial-lined cyst formation of bronchogenic origin, and finally (late in infection) partial resolution of the host response. Bronchograms and mechanical probing illustrate the patency of cyst communication with bronchi. The modulation of the host response and adaptive changes in the host lung tissue are seen late in infection and have previously been unreported or underemphasized. These adaptive responses may account for the number of asymptomatic cases accidentally found in veterinary patients and the difficulty in prompt and proper diagnosis in human cases.
authors: Department of Zoology, University of Wisconsin, Madison 53706.
authors: P J
authors: PJ
authors: Weina
authors: D M
authors: DM
authors: England
mesh_terms: D000818:Animals; D001995:Bronchography; D002415:Cats; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D008168:Lung / Q000469:parasitology / Q000473:pathology; D008174:Lung Diseases, Parasitic / Q000469:parasitology*; D010237:Paragonimiasis / Q000469:parasitology*; D010238:Paragonimus / Q000502:physiology*; D010994:Pleura / Q000473:pathology; D013047:Specific Pathogen-Free Organisms