Androgen-regulated proteins in the rat ventral prostate.
The rat ventral prostate synthetizes and secretes a number of relatively abundant proteins, such as Prostatic Binding Protein (PBP), the Proline-Rich Polypeptides (PRP), the 20 or 22-kDa protein and a prostatic protease, which respectively constitute approx. 50, 5, 10 and 2% of the secreted protein. The synthesis of these proteins is androgen-regulated and this is also the case for the concentration of the corresponding mRNAs. The existence of a putative androgen response element in the first intron of the PBP-C3 gene supports the possibility of a direct control of its transcription by androgen receptor complexes, but there is also evidence for the requirement of protein synthesis for mRNA stimulation. Finally, changes of tissue composition and cell-cell interactions between epithelial and stromal cells most probably play an important role in the global effect of androgens on the rat ventral prostate.
Heyns
W
W
Laboratorium voor Experimentele Geneeskunde en Endoctrinologie, Faculteit Geneeskunde, Katholieke Universiteit, Leuven/Belgium.
D000728:Androgens / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats
D000728:Androgens; D011506:Proteins; D012333:RNA, Messenger