[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Pre-operative chemotherapy for 7 days with 5'-DFUR (p.o.) were carried out in the patients with gastric, breast, thyroid and colon cancers. The concentration of 5-fluorouracil (5-FU) in tumor cells was higher than that in the normal tissue. In case of breast cancer, it was 10 times higher than normal tissue. The concentration of 5-FU at the metastatic lymph nodes in gastric cancer was considerably high. The pattern of DNA histogram changed when chemotherapy was applied, and we observed the G2 and M phase block.
Munemoto
Y
Y
Dept. of Surgery (I), Kanazawa University School of Medicine.
Omura
K
K
Hikishima
H
H
Okada
Y
Y
Hayashi
H
H
Adachi
I
I
Douden
K
K
Watanabe
Y
Y
Iwa
T
T
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D002453:Cell Cycle / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005472:Fluorouracil / Q000493:pharmacokinetics; D006801:Humans; D008198:Lymph Nodes / Q000201:enzymology / Q000378:metabolism; D010430:Pentosyltransferases / Q000378:metabolism; D011300:Preoperative Care; D057845:Pyrimidine Phosphorylases; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D005467:Floxuridine; D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases; D005472:Fluorouracil; C025034:doxifluridine