[The enteral absorption of iron (II) from humic acid-iron complexes in suckling piglets using radiolabeled iron (59Fe)].
Bioavailability of iron (II) bounded as a chelate to macromolecular humic acids was investigated in two different concentrations using retention rates of 59Fe in piglets (age: 24 h). Investigations period was from 3 hrs. to 21 days following application. 21 days after a single oral application of the humic-acid-iron-complexes, 25% of the total Fe was detected in the animal, distributed in the erythrocytes (80%), muscles and bones (8% respectively) and liver (4%). For the first time in veterinary medicine these results enable a combined therapy of enteric and iron-deficiency syndrome by using only one drug. Recommendation for dosing is provided.
Fuchs
V
V
Institut für Pharmakologie, Pharmazie und Toxikologie, Karl-Marx-Universität Leipzig, DDR.
Kühnert
M
M
Golbs
S
S
Dedek
W
W
D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001682:Biological Availability; D006812:Humic Substances / Q000378:metabolism*; D007408:Intestinal Absorption; D007501:Iron / Q000493:pharmacokinetics*; D011817:Rabbits; D013552:Swine / Q000378:metabolism*; D014018:Tissue Distribution
D006812:Humic Substances; D007501:Iron
Untersuchungen zur enteralen Resorption von Eisen (II) aus Huminsäure-Eisen-Komplexen beim Saugferkel mit Hilfe radiomarkierten Eisens (59Fe).