title: Microwave effect upon chlorpromazine-inhibited kidney ATPase.
abstract: Presence of chlorpromazine, a non-active-site inhibitor of Na(+)-K(+)-ATPase catalytic activity, in a reaction system exposed to 9.14 GHz CW radiation, resulted in approximately 23% inhibition. This effect was temperature-independent within the normal range for this protein. A low-level microwave field also inhibited the enzyme catalytic rate. Loci of chlorpromazine inhibition and of low-level microwave inhibition appear to be distinct and non-interactive under the conditions of this study. Use of enzyme reaction systems as models for microwave causation of leukemia and the possible involvement of pharmacological agents, such as ouabain and chlorpromazine, in this process has been considered.
authors: Department of Biochemistry, NJAES, Rutgers University, New Brunswick 08903.
authors: H D
authors: HD
authors: Brown
authors: S K
authors: SK
authors: Chattopadhyay
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000528:radiation effects*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D004285:Dogs; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D008872:Microwaves; D013816:Thermodynamics
chemical_list: D000251:Adenosine Triphosphatases; D002746:Chlorpromazine