Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis.
To investigate the effects of medical treatment of endometriosis on concentrations of insulin and glucagon in comparison with those of androgens, 12 non-obese women with minimal endometriosis were randomly allocated to receive treatment with either danazol or the gonadotropin-releasing hormone analogue, goserelin. In subjects treated with danazol, mean (SD) summed serum insulin (1.08 (0.22) nmol/l pretreatment; 3.00 (1.50) nmol/l after treatment, p less than 0.05) and summed plasma glucagon (94 (21) pmol/l pretreatment; 238 (113) pmol/l after treatment, p less than 0.05) responses to oral glucose administration increased significantly, but remained unchanged in subjects treated with goserelin. In the danazol-treated group, the mean free testosterone index increased from 3.3 (1.6) to 13.3 (4.2) (p less than 0.01), but there was no correlation between either glucagon or insulin and free testosterone index. In the goserelin-treated subjects, however, there was no change in mean free testosterone indices (pretreatment 3.6 (1.0), post-treatment 3.9 (1.8). Thus, the increase in free testosterone index induced by danazol treatment is not responsible for the concomitant development of hyperinsulinaemia and hyperglucagonaemia.
Golland
I M
IM
Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.
Vaughan-Williams
C A
CA
Shalet
S M
SM
Laing
I
I
Elstein
M
M
D000328:Adult; D000728:Androgens / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002064:Buserelin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002096:C-Peptide / Q000097:blood; D003613:Danazol / Q000009:adverse effects* / Q000627:therapeutic use; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005934:Glucagon / Q000097:blood*; D005951:Glucose Tolerance Test; D017273:Goserelin; D006801:Humans; D007328:Insulin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D013739:Testosterone / Q000097:blood
D000728:Androgens; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D017273:Goserelin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005934:Glucagon; D003613:Danazol; D002064:Buserelin