title: Studies on aldose reductase inhibitors from medicinal plant of "sinfito," Potentilla candicans, and further synthesis of their related compounds.
abstract: For several years we have screened natural products having aldose reductase (AR) inhibitory activity. 3,3',4-Tri-O-methylellagic acid 4'-sulfate potassium salt (2) was isolated from a Mexican herb "Sinfito" (Potentilla candicans) as a potent AR inhibitory active constituent. 2 was more potent (IC50 = 8.0 x 10(-8)M) than ellagic acid, which is one of the natural inhibitors of AR. So we examined the synthesis of ellagic acid derivatives and found that the sulfate group is one of the important function.
authors: Toyo Pharmar Co., Ltd., Toyama, Japan.
authors: S
authors: S
authors: Terashima
authors: M
authors: M
authors: Shimizu
authors: H
authors: H
authors: Nakayama
authors: M
authors: M
authors: Ishikura
authors: Y
authors: Y
authors: Ueda
authors: K
authors: K
authors: Imai
authors: A
authors: A
authors: Suzui
authors: N
authors: N
authors: Morita
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000201:enzymology; D008800:Mexico; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats
chemical_list: D000449:Aldehyde Reductase