title: Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines.
abstract: The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells. Micromolar concentrations of 8-HQ inhibited the growth of B16 cells as well as human melanoma cell lines. Removal of 8-HQ from the culture medium restored normal cell growth. Growth inhibition by 8-HQ was accompanied by phenotypic alterations that included changes in cell morphology, increased production of melanin and enhanced activities of the enzymes gamma-glutamyl transpeptidase and NADPH cytochrome c reductase. These changes might be associated with a better differentiated phenotype.
authors: Rogoff Research Institute, Beilinson Medical Center, Petah Tikva, Israel.
authors: J
authors: J
authors: Nordenberg
authors: A
authors: A
authors: Novogrodsky
authors: E
authors: E
authors: Beery
authors: M
authors: M
authors: Patia
authors: L
authors: L
authors: Wasserman
authors: A
authors: A
authors: Warshawsky
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D015125:Oxyquinoline / Q000627:therapeutic use*
chemical_list: D015125:Oxyquinoline