[Subchronic toxic effect of the grain fungicide PF-70 on the electrolyte barrier of the gastric mucosa in rats].
The fungicide for corn PF-70 contains 21% of sulphur, 8.4% of mancozeb, and 0.6% of triadimefon . The aim of the study was to determine the effect of the fungicide on the gastric mucosa electrolyte barrier in rats. Mucosa lesion is known to be one of the risk factors of chronic peptic ulcer disease. The experiments were carried out on 80 rats of Wistar strain. The animals were divided into 5 groups--males and females, separately. The fungicide was given for 13 weeks, at the following doses: 100, 400, 1600, and 6400 mg of active substance per 1 kg of fodder. The gastric mucosa electrolyte barrier was examined by determining the transmural electric potential differences (PD) in mucosa before and after treatment with 150 mmlo of hydrochloric acid and 40 mmol of acetylsalicylic acid solutions. No changes in general condition of the animals were observed. An increase in fodder consumption was observed in males receiving the fungicide at doses of 1600 and 6400 mg per 1 kg of fodder. Females exhibited a decrease in body mass after intoxication at concentration of 6400 mg/kg fodder. A decrease in PD was found in all groups intoxicated with the fungicide, irrespective of the animal sex.
Jonderko
G
G
IV Katedry i Kliniki Chorób Wewnetrznych Sl. AM Kierownik.
Lachowicz
K
K
Kita
I
I
Kita
K
K
Knapek
R
R
Kotulska
A
A
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D002523:Edible Grain / Q000382:microbiology*; D004553:Electric Conductivity / Q000187:drug effects / Q000502:physiology; D005260:Female; D005659:Fungicides, Industrial / Q000506:poisoning*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008344:Maneb / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D013455:Sulfur / Q000506:poisoning*; D014230:Triazoles / Q000506:poisoning*; D015038:Zineb / Q000506:poisoning*
D005659:Fungicides, Industrial; C071454:PF 70; D014230:Triazoles; D008344:Maneb; D013455:Sulfur; D015038:Zineb
Wpływ podprzewlekłego zatrucia fungicydem do zbóz PF-70 na bariere elektrolitowa błony śluzowej zoładka szczurów.