title: Penetrating keratoplasty for keratoconus in Down's syndrome.
abstract: Five patients with Down's syndrome underwent penetrating keratoplasty for keratoconus. In three patients, the indication for surgery was acute corneal hydrops, which had not resolved in the three months before surgery. The other two patients had corneal scars. Two patients had combined penetrating keratoplasty, cataract extraction, and intraocular lens insertion. Four of the five patients maintained clear grafts at their most recent follow-up examination. Two of the five patients had one or more graft reaction episodes; one graft was lost. Good results can be obtained in penetrating keratoplasty for keratoconus in patients with Down's syndrome who do not demonstrate a tendency toward excessive eye rubbing and for whom a single observant caretaker can be relied on to provide consistent postoperative care.
authors: Louisiana State University Medical Center School of Medicine 70112-2234.
authors: J M
authors: JM
authors: Frantz
authors: M S
authors: MS
authors: Insler
authors: M
authors: M
authors: Hagenah
authors: M B
authors: MB
authors: McDonald
authors: H E
authors: HE
authors: Kaufman
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D006085:Graft Survival; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000601:surgery*; D015948:Keratoplasty, Penetrating; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014792:Visual Acuity