Thiamine tetraphydrofurfuryl disulfide in nutritional polyneuropathy.
An open trial with thiamine tetrahydrofurfuryl disulphide (TTFD) was carried out on 44 patients with nutritional polyneuropathy who were admitted to the Neurological Department, Dr. Soetomo Hospital, Surabaya, Indonesia, Thirty-four patients showed improvement of their motor functions (P less than 0.01) with slight restoration of sensory function and reflexes (P less than 0.1). Of the 18 patients who were re-examined electrophysiologically 3 months later, 6 showed remarkable improvements. No side-effects were observed during TTFD treatment. It seemed that nutritional polyneuropathy in our low socio-economic patients was mostly caused by thiamine deficiency.
Djoenaidi
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Department of Neurology, Airlangga University, Faculty of Medicine, Dr. Soetomo Hospital, Surabaya, Indonesia.
Notermans
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SL
D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003906:Developing Countries; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005666:Fursultiamin / Q000008:administration & dosage*; D006801:Humans; D007214:Indonesia; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D009460:Neurologic Examination; D011115:Polyneuropathies / Q000188:drug therapy*; D011743:Pyrimidines / Q000008:administration & dosage*; D013832:Thiamine Deficiency / Q000188:drug therapy*
D011743:Pyrimidines; D005666:Fursultiamin