[Antitrichomonal properties of derivatives of ethers containing amine and halogenarylalkyl groups].
The trichomonacidal activity in vitro of 6 new derivatives of theirs containing amine and halogenaryloalkyl groups in comparison with metronidazole, ornidazole and tinidazole has been examined. For all the examined compounds curves of action were obtained after 30 min, and lethal concentrations for 50% population (CL50) of three strains of T. vaginalis used for experiments were calculated. The trichomonacidal action of the following compounds was specially strong: 2-/1-methylpiperazine++-4-yl/ethyl-4-chlorbenzhydryl ether dihydrochloride and 2-/1-benzylperhydro-1,4-diazepine++-4-yl/ethyl 2,4-dichlorbenzyl ether dihydrochloride. The trichomonacidal action of these compounds was several times stronger than that of metronidazole and tinidazole.
Białasiewicz
D
D
Zakład Biologii i Parazytologii Lekarskiej, Instytut Biologiczno-Morfologiczny AM Lódz.
Kotełko
B
B
Kurnatowska
A
A
Kwaśniewska
J
J
D000818:Animals; D000994:Antitrichomonal Agents / Q000737:chemistry / Q000494:pharmacology*; D003470:Culture Media; D066298:In Vitro Techniques; D008795:Metronidazole / Q000494:pharmacology; D009950:Ornidazole / Q000494:pharmacology; D014011:Tinidazole / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000994:Antitrichomonal Agents; D003470:Culture Media; D014011:Tinidazole; D008795:Metronidazole; D009950:Ornidazole
Właściwości przeciwrzesistkowe pochodnych eterów zawierajacych reszty aminowe i chlorowcoaryloalkilowe.