[Peripheral blood lymphocyte subsets in acute relapsing multiple sclerosis].
Anti-Leu series of monoclonal antibodies were used to evaluate lymphocyte subsets with ABC staining method. The peripheral blood total T cells (Tt), helper T cells (Th), suppressor T cells (Ts) and B cells were counted in 10 cases of acute relapsing MS, in which 7 cases had been investigated consecutively. Controls included 12 cases of remitting MS, 18 patients with other neurological diseases and 56 healthy subjects. The results showed that the peripheral blood Ts decreased in number and the Th/Ts ratio elevated during acute relapsing stage of MS, and they tended to return to normal when the disease showed a gradual recovery (The patients with longer periods of high Th/Ts ratio had more serious manifestations of the illness more severe disability) and the relapsing stage would be longer too.
Yang
Y C
YC
Department of Neurology, Beijng Union Medical College Hospital, Chinese Academy of Medical Sciences.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D012008:Recurrence; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000911:Antibodies, Monoclonal