[An evaluation of the effect of light on a commercial solution of amino acids for parenteral nutrition].
There are few studies on the stability of amino acids in solutions prior to mixing for parenteral nutrition, and even few studies which evaluate the contribution of light to their deterioration. The present study was carried out with the aim of becoming familiar with this parameter of stability in the working conditions of our Pharmacy Service. Two batches of Aminoplasmal L-10 were taken, one of which was subjected to direct low intensity sunlight and the other was maintained in the dark, as a control batch, for between 3-6 months. At the end of this time, complete aminograms were performed by ionic interchange chromatography. The measurements of concentrations of each amino acid were obtained for each batch. A Student T test was used to show that there were no significant differences between them after both 3 and 6 months. It was therefore concluded that the amino acid solution we had tested was maintained stable under the light exposure conditions of our Service after 6 months.
Santos Ramos
B
B
Servicio de Farmacia, Hospital Universitario Virgen del Rocío, Sevilla.
Quintero García
P
P
Piña Vera
M J
MJ
Tosca Vives
M
M
Lluch Colomer
A
A
D000596:Amino Acids / Q000032:analysis / Q000528:radiation effects*; D002852:Chromatography, Ion Exchange; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008027:Light; D010288:Parenteral Nutrition; D012996:Solutions; D013472:Sunlight; D013997:Time Factors
D000596:Amino Acids; D012996:Solutions
Valoración del efecto de la luz sobre una solución comercial de aminoácidos para nutrición parenteral.