title: Superior sagittal sinus thrombosis in a patient with protein S deficiency.
abstract: A 30-year-old man presented with sagittal sinus thrombosis. He had a history of multiple thrombotic events since adolescence, and his father had had a similar history. Laboratory studies revealed the complete absence of free protein S in his plasma. Protein S deficiency, an autosomal dominant disorder, is an identifiable cause of cerebral thrombosis. The literature and our experience with this case suggest that long-term anticoagulant therapy may prevent thrombotic episodes in patients with this disorder.
authors: Department of Psychiatry, Tulane University School of Medicine, New Orleans, Louisiana.
authors: D
authors: D
authors: Cros
authors: P C
authors: PC
authors: Comp
authors: G
authors: G
authors: Beltran
authors: G
authors: G
authors: Gum
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male; D017293:Protein S; D012851:Sinus Thrombosis, Intracranial / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D006023:Glycoproteins; D017293:Protein S; D014859:Warfarin