Aldosterone receptors are involved in the mediation of the memory-enhancing effects of piracetam.
The blockade of the memory-enhancing effects of piracetam resulting from adrenalectomy can be abolished by substitution with either corticosterone or aldosterone. However, corticosterone substitution does not reinstate these effects if the aldosterone receptors are blocked by the aldosterone antagonist epoxymexrenon.
Mondadori
C
C
Pharmaceutical Research Department, CIBA-GEIGY Limited, Basel, Switzerland.
Häusler
A
A
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003345:Corticosterone / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000494:pharmacology*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology*; D018161:Receptors, Mineralocorticoid; D012016:Reference Values
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D003345:Corticosterone; D010889:Piracetam