title: Episodic angioedema with eosinophilia (Gleich syndrome).
abstract: A case of episodic angioedema with hypereosinophilia or otherwise called Gleich's syndrome is reported. The patient was a young woman with a six-year history of recurrent angioedema, itchy urticaria, rapid weight gain and hypereosinophilia. The main clinical, laboratory, and immunological findings included systemic angioedema, urticaria, 12% weight gain and leucocytosis (69.150 WBC/cu mm) with eosinophils of 75.6%. Circulating IgM, IgE, and T-helper lymphocyte were elevated. Skin biopsy showed an important perivascular eosinophil infiltration. The absence of concomitant allergic, malignant and connective disorders, and a dramatic clinical improvement with a fall of the eosinophil count to normal levels following corticosteroid therapy was the basis for our diagnosis.
authors: Department of Allergology, Catholic University, Rome, Italy.
authors: D
authors: D
authors: Schiavino
authors: N
authors: N
authors: Gentiloni
authors: F
authors: F
authors: Murzilli
authors: M
authors: M
authors: Gebreselassie
authors: L M
authors: LM
authors: La Rocca
authors: G
authors: G
authors: Patriarca
mesh_terms: D000328:Adult; D000799:Angioedema / Q000276:immunology / Q000473:pathology; D001623:Betamethasone / Q000627:therapeutic use; D004802:Eosinophilia / Q000145:classification / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007958:Leukocyte Count; D013577:Syndrome; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D015430:Weight Gain
chemical_list: D007075:Immunoglobulin M; D007073:Immunoglobulin E; D001623:Betamethasone