Metabolic products of microorganisms. 255. Nikkomycins Wz and Wx, new chitin synthetase inhibitors from Streptomyces tendae.
Two new dipeptidyl nikkomycins of the Z and X type were isolated from the culture broth of Streptomyces tendae TU 901/395-11/32 and characterized. They show a variation in the amino acid moiety of the molecule. Nikkomycin Wz is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to uracil, whereas nikkomycin Wx is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to 4-formyl-4-imidazolin-2-one. The new nikkomycins are good inhibitors of chitin synthetase from Coprinus cinereus but they did not inhibit growth of fungi and yeasts.
Decker
H
H
Biologisches Institut, Universität Tübingen, FRG.
Walz
F
F
Bormann
C
C
Zähner
H
H
Fiedler
H P
HP
Heitsch
H
H
König
W A
WA
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C011952:nikkomycin; D005964:Glucosyltransferases; D002687:Chitin Synthase