[The effects of renin, angiotensin II, antidiuretic hormone (ADH) and alpha-atrial natriuretic peptide (alpha-ANP) on renal dysfunction induced by IPPV with PEEP].
We investigated the effects of hormonal changes on decreased urine output induced by IPPV with PEEP in 8 dogs anesthetized with nitrous oxide-oxygen-pentobarbital. The decreased urine output could be attributed to the hemodynamic changes as previously reported. The results of this investigation suggest that renin, angiotensin II and ADH do not have significant influences on the decreased urine output. However, the decrease in alpha-ANP which might have been caused by the compression of the atria and the decrease of venous return induced by IPPV with PEEP, may be the cause of the decrease in urine output.
Yamada
S
S
Department of Anesthesia, Ishikawa Prefectural Hospital, Kanazawa.
Saeki
Y
Y
Yamamoto
K
K
Kobayashi
T
T
Murakami
S
S
D000804:Angiotensin II / Q000627:therapeutic use*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use*; D004285:Dogs; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects*; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D012083:Renin / Q000627:therapeutic use*; D016055:Urinary Retention / Q000188:drug therapy / Q000209:etiology*; D014667:Vasopressins / Q000627:therapeutic use*
D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D012083:Renin