Haemorrhage produces depressions in alloantigen-specific immune responses in the mouse through activation of suppressor T cells.
The development of cell-mediated and humoral immune responses in BALB/c mice (H-2d) directed toward El4 cells (H-2b) was suppressed (cell-mediated cytotoxicity, 40-50% of control; antibody titres 127 +/- 17 versus 287 +/- 17 in controls) following haemorrhage of 30% total blood volume. This haemorrhage-induced depression of immune response can be transferred to normal recipients with T cells (3 x 10(7] from haemorrhaged syngeneic donors. Flow microfluorimetry (FMF) analysis showed no shift in CD8:CD4 ratios following haemorrhage. These results suggest that haemorrhage suppresses immune response through activation of suppressor T cells.
Chang
Y H
YH
Department of Medicine, UCLA School of Medicine 90024-1670.
Jagels
M
M
Abraham
E
E
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D006470:Hemorrhage / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology; D007518:Isoantibodies / Q000096:biosynthesis; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors
D007518:Isoantibodies; D007519:Isoantigens