Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs.
A series of studies in human subjects of potential interactions of lornoxicam with some other drugs is reviewed. No evidence of kinetic interaction was found with the antacids Maalox or Solugastrol, nor was there evidence of influence on antipyrine clearance. Lornoxicam reduced warfarin clearance and enhanced its hypoprothrombinaemic effect. It did not influence glibenclamide kinetics, but plasma insulin concentrations were significantly higher and plasma glucose concentrations significantly lower when lornoxicam and glibenclamide were co-administered. Lornoxicam produced a modest reduction in digoxin clearance, but no other clear evidence of interaction was seen. Lornoxicam significantly antagonized the diuretic and natriuretic actions of frusemide.
Ravic
M
M
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Johnston
A
A
Turner
P
P
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004077:Digoxin / Q000493:pharmacokinetics; D004347:Drug Interactions; D005665:Furosemide / Q000037:antagonists & inhibitors; D005905:Glyburide / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D014859:Warfarin / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D014859:Warfarin; D004077:Digoxin; D005665:Furosemide; C059451:lornoxicam; D005905:Glyburide