Laboratory identification of conditions predisposing to thrombosis.
The 5-year experience with a panel of laboratory tests designed to identify patients with high risk of thromboembolism was reviewed. This panel included an activated partial thromboplastin time and reptilase time as well as specific assays for antithrombin III, protein C, protein S, and plasminogen. One hundred and nine patients were evaluated by this panel. Conditions predisposing to thrombosis were identified in 24 of these patients and these conditions included: dysfibrinogenemia, lupus anticoagulant, and deficiencies of antithrombin III, protein C and protein S. The limitations of this panel are also discussed.
Sanfelippo
M J
MJ
Department of Laboratory Medicine, Columbia Hospital, Milwaukee.
Caya
J G
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000032:analysis; D001780:Blood Coagulation Tests; D001798:Blood Proteins / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D011486:Protein C / Q000032:analysis; D017293:Protein S; D012307:Risk Factors; D013918:Thrombin Time; D013923:Thromboembolism / Q000097:blood* / Q000175:diagnosis
D001798:Blood Proteins; D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D010958:Plasminogen