Behavioral sensitization following a single apomorphine pretreatment--selective effects on the dopamine release process.
Once daily subchronic pretreatments with the dopamine (DA) agonist apomorphine (APO) increase striatal DA synthesis and metabolism. Such changes imply that adaptations to APO do not dissipate completely within 24 h. In the present report we evaluated the effects of a single APO treatment 24 h prior to euthanasia on behavior and on striatal DA synthesis, metabolism, release and receptor binding. The single APO pretreatment reduced DA release from striatal synaptosomes. In contrast, striatal DA synthesis, metabolism, and the high-affinity binding of DA to the D2 receptor were unaltered 24 h after agonist pretreatment. At this time the stereotypic response to a subsequent APO challenge was enhanced. This adaptive pattern is different from that observed 60 min following an acute APO pretreatment, when high-affinity D2 binding is reduced. The pattern 24 h following a single APO pretreatment is also different from that observed following subchronic agonist dosing, when stereotypic behavior is enhanced, while basal DA synthesis and metabolism are increased.
Wilcox
R E
RE
Department of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin.
Severson
J A
JA
Woodward
J J
JJ
Randall
P K
PK
Vaughn
D M
DM
Riffee
W H
WH
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000378:metabolism; D017448:Receptors, Dopamine D2; D013239:Stereotyped Behavior; D013997:Time Factors
D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D001058:Apomorphine; D004298:Dopamine