[Comparative studies on progressive and superficial marginal periodontitis].
It was the objective of the present study to investigate the local inflammatory and immune response in patients with superficial (SMP) and progressive marginal periodontitis (PMP). In a preliminary study the distribution of macrophage subpopulations was analysed during experimental gingivitis using monoclonal antibodies. A significant increase in the number of inflammatory macrophages was observed during acute gingivitis. In the second part of the study, the distribution of the macrophage subpopulations, T-helper and -suppressor cells, B-lymphocytes and plasma cells as well as the total anaerobic microflora were determined during periodontal therapy. Before periodontal surgery PMP-patients demonstrated significantly more inflammatory macrophages and plasma cells and a significantly higher prevalence of Bacteroides gingivalis, Peptococcus species and Actinobacillus actinomycetemcomitans. The different local immune responses in PMP-patients might be caused by a distinct subgingival microflora, since no differences were observed in the number of the immunocompetent cells and the subgingival flora after successful periodontal treatment.
Topoll
H H
HH
Zentrum für Zahn-, Mund- und Kieferheilkunde der Westfalischen Wilhelms-Universität Munster.
D000188:Actinobacillus / Q000302:isolation & purification; D000328:Adult; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D001439:Bacteroides / Q000302:isolation & purification; D005260:Female; D005891:Gingivitis / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008297:Male; D010460:Peptococcus / Q000302:isolation & purification; D010518:Periodontitis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal
Vergleichende Untersuchungen bei fortgeschrittener und superfizieller marginaler Parodontitis.