title: Sulfadiazines prevent plaque formation and gingivitis in beagles.
abstract: The effect of zinc sulfadiazine (ZnSD) and silver sulfadiazine (AgSD) on developing plaque formation and gingivitis was studied in 12 beagle dogs over a 14-week period. Plaque and gingival indices were used to measure plaque formation and gingivitis. During a 2-wk baseline period each dog was brought to optimal gingival health with prophylaxis and tooth brushing. Thereafter, 4 dogs were treated twice daily with topical application of 3.0% zinc sulfadiazine; 4 dogs were treated with 2.0% silver sulfadiazine while 4 dogs treated with placebo gel served as controls over a 12-wk treatment period. At wk 2 of treatment, all three groups of dogs showed an increase in plaque build-up on their teeth from baseline. By wk 6, plaque accumulation on the teeth was significantly less in dogs treated with either ZnSD or AgSD compared to control dogs. At wk 2 of treatment, gingival inflammation was increased from baseline in all three groups. Thereafter, over the course of the 12-wk treatment period, gingival inflammation in the ZnSD and the AgSD treated dogs was significantly less than the placebo treated dogs. The data indicate that both ZnSD and AgSD inhibit developing plaque formation in beagles. This significant inhibition of plaque formation was accompanied by a significant reduction in gingival inflammation.
authors: Department of Periodontology, Harvard School of Dental Medicine, Boston, MA.
authors: T H
authors: TH
authors: Howell
authors: M S
authors: MS
authors: Reddy
authors: H P
authors: HP
authors: Weber
authors: K L
authors: KL
authors: Li
authors: M C
authors: MC
authors: Alfano
authors: R
authors: R
authors: Vogel
authors: A C
authors: AC
authors: Tanner
authors: R C
authors: RC
authors: Williams
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004285:Dogs; D005260:Female; D005782:Gels; D005891:Gingivitis / Q000517:prevention & control*; D010512:Periodontal Index; D010919:Placebos; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005782:Gels; D010919:Placebos; D013411:Sulfadiazine; D012837:Silver Sulfadiazine