Comparison of the pharmacology of nafarelin and danazol.
The pharmacologic profiles of danazol and nafarelin differ considerably from each other. Danazol interacts with multiple classes of proteins, whereas the gonadotropin-releasing hormone agonist nafarelin interacts only with the pituitary gonadotropin-releasing hormone receptor. Differences in the molecular, endocrine, and clinical pharmacologic properties of these agents may provide clues to their varying effects in the management of women with endometriosis.
Barbieri
R L
RL
Department of Obstetrics and Gynecology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115.
D000818:Animals; D003613:Danazol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D017274:Nafarelin; D010053:Ovary / Q000187:drug effects; D011245:Pregnadienes / Q000494:pharmacology*; D011987:Receptors, Steroid / Q000187:drug effects; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis
D011245:Pregnadienes; D011987:Receptors, Steroid; D012738:Sex Hormone-Binding Globulin; D013256:Steroids; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; D003613:Danazol