Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression.
Changes in cellular gene transcription patterns induced by extracellular signals are thought to be important for many biological processes, including the control of cell growth. The transmission of gene regulatory signals through the cytoplasm is mediated by signaling pathways, of which protein kinases are important components, and recent evidence suggests that communication between the cytoplasm and nucleus relies on signal-dependent phosphorylation and dephosphorylation of transcription factors. This new information is reviewed and the implications for gene regulation and the control of cell growth are discussed.
Bohmann
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European Molecular Biology Laboratory, Differentiation Programme, Heidelberg, FRG.
D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D008957:Models, Genetic; D020626:Oncogene Proteins v-myb; D010766:Phosphorylation; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun; D020598:Proto-Oncogene Proteins c-myb; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D020598:Proto-Oncogene Proteins c-myb; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors