A Chinese family with non-insulin-dependent diabetes of early onset and severe diabetic complications.
Non-insulin-dependent diabetes mellitus of early onset has recently been described in Caucasians as a distinct syndrome with a characteristic pedigree suggestive of inheritance of genetic determinants from both parents. It is characterized by absence of islet cell antibodies and the severity of its clinical course. We report a Chinese family pedigree of three generations in which this form of diabetes has affected the third generation. Some members of this pedigree had severe complications at presentation in their twenties.
Chan
J C
JC
Department of Medicine, Chinese University of Hong Kong.
Hawkins
B R
BR
Cockram
C S
CS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005951:Glucose Tolerance Test; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree