[The effect of gangliosides on the adhesive interaction of Neisseria meningitidis with human cells].
The influence of a number of gangliosides and sialic acid on the adhesive interaction of meningococci and human cells have been studied. Sialic acid has been found to produce no influence on adhesion, and the preliminary treatment of meningococci with gangliosides or their preparations suppresses the capacity of meningococci for attachment to epithelial cells and erythrocytes. At the same time the degree of the inhibition of adhesion depends on the kind and concentration of gangliosides. On the contrary, after the treatment of target cells with gangliosides (1.25 micrograms/ml) the adhesion indices of meningococci with respect to these cells increase 5- to 8-fold. These data are indicative of the participation of gangliosides in the adhesive interaction of meningococci and human cells.
Rumiantsev
S N
SN
Avrova
N F
NF
Pospelov
V F
VF
Denisova
N A
NA
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000382:microbiology; D004912:Erythrocytes / Q000187:drug effects / Q000382:microbiology; D005732:Gangliosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000382:microbiology; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects / Q000382:microbiology; D019158:N-Acetylneuraminic Acid; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000472:pathogenicity; D012794:Sialic Acids / Q000494:pharmacology; D013552:Swine
D005732:Gangliosides; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid
Vliianie gangliozidov na adgezivnoe vzaimodeĭstvie Neisseria meningitidis s kletkami cheloveka.