[The effect of rate of administration of isradipine on the hemodynamic response].
As the magnitude of drug response may depend on its input rate, we investigated the rate of administration-effect relationship of the new dihydropyridine isradipine. Ten healthy volunteers received (double-blind and cross-over) isradipine 1 mg i.v. (5 min), 5 mg solution, 5 mg tablet, 10 mg sustained release, and placebo. Blood pressure and heart rate were recorded for 24 h. A single dose of slow-release formulation isradipine does not induce significant hemodynamic effects in healthy subjects. The maximal BP fall was comparable with either i.v., solution, and conventional tablet administration. This is due to a stronger heart rate counter-regulation, linked to rapid isradipine administration. These results imply that slow input rates of isradipine are more effective in lowering blood pressure.
Carrara
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Division de pharmacologie clinique, Hôpital cantonal universitaire, Genève.
Porchet
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HC
Dayer
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D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D017275:Isradipine; D008297:Male; D011725:Pyridines / Q000008:administration & dosage* / Q000494:pharmacology
D000959:Antihypertensive Agents; D011725:Pyridines; D017275:Isradipine
Influence de la vitesse d'administration sur la réponse hémodynamique de l'isradipine.