A case of Graves' disease associated with Klinefelter's syndrome.
Graves' disease was found in a 41-year-old, married male patient with Klinefelter's syndrome. The patient began having finger tremor 5 years previously, and developed palpitation and weight loss 3 months prior to examination. He had a diffuse goiter, exophthalmos, and atrial fibrillation. Plasma levels of T3, T4 and free T4 were 2.8 ng/ml, 16.6 micrograms/dl and 4.5 ng/dl respectively. [123I] uptake was 53%, and TSH receptor antibody was 75%. Although he had no gynecomastia, his general physical appearance was that of typical eunuchoism. Chromosome studies showed a karyotype of 47,XXY. A diagnosis of Graves' disease associated with Klinefelter's syndrome was made.
Yamashita
S
S
Third Department of Medicine, Miyazaki Medical College, Japan.
Nagamine
M
M
Kuribayashi
T
T
Matsukura
S
S
D000328:Adult; D007987:Gonadotropin-Releasing Hormone; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine