title: Effects of norepinephrine on hepatic amino acid metabolism in isolated perfused rat liver.
abstract: The effects of norepinephrine (NE) on hepatic amino acid exchanges were studied in the isolated perfused rat liver using a recirculating system with a medium containing amino acids at twice physiologic concentrations. Norepinephrine induced a significant decrease (25%) in portal blood flow at a concentration of 2 ng/ml (10(-8) M). The hormone also increased total hepatic amino acid uptake, essentially through a switch from glutamine release to net uptake. There was no modification in free intracellular amino acids, but glycogen was slightly decreased, and glucose production was increased. Taken as a whole, these results suggest that NE modulates hepatic protein balance.
authors: Laboratoire de Biochimie A, Hopital Saint Antoine, Paris, France.
authors: J P
authors: JP
authors: De Bandt
authors: F
authors: F
authors: Ballet
authors: L
authors: L
authors: Cynober
authors: C
authors: C
authors: Rey
authors: C
authors: C
authors: Coudray-Lucas
authors: J
authors: J
authors: Giboudeau
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D005973:Glutamine / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000596:Amino Acids; D005973:Glutamine; D009638:Norepinephrine