[Effects of long-term treatment with calcium antagonists on the isomyosin composition of the hearts of spontaneously hypertensive rats].
Purpose of this study was to evaluate the long-term effects of treatment by calcium antagonists on blood pressure (BP) and cardiac isomyosins of SHR. From the fourth week of life we studied 40 SHRs and 20 Wistars in standard conditions and at the twelfth week, when SHRs already showed high BP and left ventricular hypertrophy (LVH), we treated 10 of them by nifedipine (N) (30 mg/Kg/die) and 10 by verapamil (V) (100 mg/Kg/die). BP was measured by tail-cuff technique. At the tenth week of treatment when the rats were sacrificed, LVH index and isomyosinic profile were evaluated. The results obtained demonstrate that: at the twenty-second week, V1 was 17% in untreated SHR, 90% in N and 75% in V while V3 was 80% in the untreated group, 8% in N and 15% in V, respectively. In conclusion, the treatment by calcium antagonists reduced BP and LVH re-establishing the predominance of V1 on V3.
Vulpis
V
V
Istituto di Patologia Speciale Medica, Università degli Studi, Bari.
Sublimi-Saponetti
L
L
Forte
D
D
Ricci
S
S
Pirrelli
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D002121:Calcium Channel Blockers; D009218:Myosins
Effetti del trattamento a lungo termine con calcioantagonisti sul profilo isomiosinico di cuori di ratti spontaneamente ipertesi.