Occurrence rate of the HLA-identical pair donor-recipient for bone marrow transplantation.
HLA antigens and MLC reactivity were ascertained in 69 families, having altogether 198 children, with the aim to find genotypically identical donors for patients suffering from some type of leukemia or aplastic anemia. HLA identical, MLC negative sibling donors were found for 29 patients, i.e. 42.03%. In 55 leukemic patients the frequency of HLA antigens and haplotypes was calculated. No significant differences were found as compared to the healthy population. One recombination between HLA-A and HLA-B and one between HLA-B and HLA-D/DR loci were observed.
Buc
M
M
Department of Microbiology and Immunology, Faculty of Medicine, Comenius University, Bratislava, Czechoslovakia.
Niks
M
M
Busová
B
B
Bláha
M
M
D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D003604:Czechoslovakia; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D014185:Transplantation, Isogeneic; D044465:White People / Q000235:genetics
D006680:HLA Antigens