[Effects of plasminogen activator on epidermal cell migration].
We studied a role of plasminogen activator and plasmin in keratinocyte migration. First we examined the effects of various proteinase inhibitors on keratinocyte migration using wound healing model in cultured keratinocyte. Among the proteinase inhibitors tested, only an inhibitor of serine proteinases, camostat mesilate showed a concentration-dependent inhibition on the migration. Anti urokinase IgG was also able to suppress the migration. On the other hand exogenous plasminogen enhanced it. These results strongly suggest that PA/plasmin system is involved in keratinocyte migration.
Nakajima
S
S
Department of Dermatology, Juntendo University School of Medicine.
Morioka
S
S
D002465:Cell Movement; D002478:Cells, Cultured; D000078404:Epidermal Cells; D005341:Fibrinolysin / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D010960:Plasminogen Activators / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
D010960:Plasminogen Activators; D005341:Fibrinolysin