[Immunoresponses and efficacy after arterial infusion of immunoconjugate A7-NCS in patients with colon cancer].
We prepared an immunoconjugate, A7-NCS, of a mouse-derived anti-human colon cancer monoclonal antibody A7 and the macromolecular protein anticancer agent neocarzinostatin (NCS), and evaluated changes in human anti-mouse antibody (HAMA) by ELISA in the serum of patients intraarterially administered this agent. IgG and IgM class HAMA were detected in all patients, but no IgE class HAMA. In patients with stage V disease, the survival rate was higher in a group treated with A7-NCS at an NCS dose of 4,000 units or more than in that treated at an NCS dose of less than 4,000 units. In these patients, the survival rate was higher in a group treated with A7-NCS at an NCS dose of 4,000 units or more than in one not treated with it. These results suggest the usefulness of A7-NCS administration at high dose for prolonging survival of patients with advanced colon cancer.
Honda
M
M
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Yamaguchi
T
T
Ohtsuji
E
E
Noguchi
A
A
Chimori
Y
Y
Doi
M
M
Kamiguchi
M
M
Noguchi
A
A
Kitamura
K
K
Yokota
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D000922:Immunotoxins / Q000276:immunology / Q000627:therapeutic use*; D051379:Mice / Q000276:immunology; D015996:Survival Rate; D009353:Zinostatin / Q000276:immunology / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D000922:Immunotoxins; D009353:Zinostatin