[In vitro study, in perfused rabbit heart, of interaction between two anti-arrhythmia agents: amiodarone and disopyramide].
The influence of 15 day's amiodarone administration (30 mg/kg/day) on myocardial uptake kinetics and electrocardiographic changes of disopyramide was examined on the isolated perfused rabbit heart (n = 24) under electrical stimulation. Amiodarone significantly reduced myocardial uptake and potentialized the effect of disopyramide on intraventricular conduction.
Akhdim
H
H
Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon.
Kantelip
J P
JP
Stimmesse
B
B
Toubin
G
G
Magnin
P
P
D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004206:Disopyramide / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D011817:Rabbits
D004206:Disopyramide; D000638:Amiodarone
Etude in vitro, sur le coeur perfusé de lapin, de l'interaction entre deux antiarythmiques: l'amiodarone et le disopyramide.