[Left ventricular mass and glomerular hyperfiltration in essential hypertension].
OBJECTIVE
to assess the early involvement to target organs in never treated essential hypertensives (HT).


METHODS
effective renal plasma flow (ERPF, 131I-Hippurate) and glomerular filtration rate (GFR, 99mTc-DTPA) were estimated in 80 mild HT. Left ventricular mass (LVM, M-mode echocardiography), sodium intake (24h UNaV) and urinary kallikrein (Kall) were also measured. Hyperfiltering patients (HF, GFR = 155 +/- 3 ml/min: 1.73 m2, n = 21) were defined by comparison with age-matched normotensive. HF patients were pair-matched for age, sex and blood pressure level with normofiltering hypertensives (NF, GFR = 112 +/- 3, n = 21).


RESULTS
are expressed as mean +/- sem [table: see text]


CONCLUSIONS
These results suggest that a high Na intake is associated with hyperfiltration and higher LVMI in subjects with never treated essential hypertension of short duration.
du Cailar
G
G
Policlinique, hôpital Lapeyronie, Montpellier.
Ribstein
J
J
Avignon
A
A
Mimran
A
A
D000328:Adult; D006332:Cardiomegaly / Q000150:complications* / Q000503:physiopathology; D004452:Echocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D006984:Hypertrophy; D008297:Male; D012964:Sodium / Q000652:urine
D012964:Sodium
Masse ventriculaire gauche et hyperfiltration glomérulaire dans l'hypertension artérielle essentielle.