title: Stress hypertension in monkeys.
abstract: 1. The influence of chronic forelimb immobilization enforcing movement in upright position on blood pressure was studied in monkeys. 2. In the course of 6 months all animals subjected to immobilization became hypertensive due to a parallel increase of systolic and diastolic pressure by about 30%. The hypertension was demonstrable both in awake and anaesthetized animals and persisted even after restitution of a normal movement regime. 3. In the chronic stage (after 15 months), the plasma renin concentration was decreased by 55%, indicating that the renin-angiotensin system activation does not participate in the maintenance of the hypertensive state. The plasma volume was diminished by 18%, while the interstitial fluid volume did not differ significantly from control values. 4. It is concluded that chronic forelimb immobilization in monkeys induces a low-renin hypertension, associated with changes in extracellular fluid compartments resembling the pattern found in the hypovolaemic type of essential hypertension.
authors: Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
authors: J
authors: J
authors: Kunes
authors: A N
authors: AN
authors: Demin
authors: J
authors: J
authors: Jelínek
authors: K
authors: K
authors: Capek
authors: G S
authors: GS
authors: Belkaniya
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007103:Immobilization / Q000502:physiology; D008253:Macaca mulatta / Q000502:physiology*; D012083:Renin / Q000097:blood; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*
chemical_list: D012083:Renin