title: [The pharmacokinetics of hematoporphyrin, its derivative and fluorescein during the development of carcinosarcoma].
abstract: The pharmacokinetics of fluorescein, hematoporphyrin and a derivative of hematoporphyrin was studied microspectrofluorometrically on rats with transplanted carcinosarcoma. It was shown that in the rats in contrast to intact animals the tissue concentration of fluorescein exhibits a general tendency towards an increase, that of hematoporphyrin towards a decrease and that of hematoporphyrin derivative towards an increase in all parenchymatous organs and a decrease in the skin and mucosae of the hollow organs. At the equally short period of the maximal accumulation of luminophores, the tumour tissue differs from the normal one by a pronounced delay of excretion only of hematoporphyrin derivative.
authors: R D
authors: RD
authors: Barabash
authors: O K
authors: OK
authors: Skobelkin
authors: M I
authors: MI
authors: Petukhov
authors: V E
authors: VE
authors: Normanskiĭ
authors: G G
authors: GG
authors: Riazhskiĭ
authors: M I
authors: MI
authors: Mironova
authors: K P
authors: KP
authors: Andreeva
authors: A S
authors: AS
authors: Kolobanov
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D005260:Female; D005452:Fluoresceins / Q000493:pharmacokinetics*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000493:pharmacokinetics*; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005452:Fluoresceins; D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative
vernacular_title: Farmakokinetika gematoporfirina, ego proizvodnogo i fliuorestseina pri razvitii kartsinosarkomy.