title: [Pulpal response to diammine silver fluoride. (2). Application on exposed pulps].
abstract: A histopathological study was attempted to investigate the pulpal response to diammine silver fluoride which was applied on the exposed pulps. Cavity preparation was performed on healthy permanent teeth on mongrel dogs with an air water spray in order to expose the pulp tissue on the small area of the cavity floors. In the experimental group (28 teeth), 0.01 ml 38% diammine silver fluoride solution was applied on the cavity floors and the exposed pulps for 3 minutes after cavity preparation. In the control group (27 teeth), nothing was applied on the cavity floors and the exposed pulps. All the cavities of these groups were left open to the oral environment without any restoration. The specimens were processed for histopathological evaluation at 3, 7 and 30 days. The teeth were fixed in 10% neutral buffered formalin, embedded in celloidin, serially sectioned through the pulp and stained with hematoxylin and eosin. The following observations were obtained. 1. After 3 days, both of the 2 groups showed such severe histopathological changes as necrosis, suppurative inflammation, round cell infiltration, bleeding and hyperemia of pulps with high percentages (77.8%-100%). 2. After 7 days, both of the 2 groups showed partial-necrosis, suppurative inflammation, round cell infiltration, bleeding and hyperemia of pulps with high percentages (63.6%-100%). 3. After 30 days, the percentages of suppurative inflammation and round cell infiltration decreased, though the percentages of complete-necrosis of pulps increased in both of the 2 groups. 4. After 30 days, cicatrization of pulps and apposition of dentin on the pulp chamber wall were observed in each of 2 teeth (25%) in the experimental group, and in each of 2 teeth (16.7%) in the control group. 5. In the 2 groups, all of the teeth except one 30-day specimen in the experimental group and one 7-day specimen in the control group, which were histopathologically evaluated as fairly success, were histopathologically evaluated as failure. 6. Application of 38% diammine silver fluoride solution did not show any protective efficacy to exposed dental pulps.
authors: Department of Pediatric Dentistry, Nagasaki University School of Dentistry.
authors: Y
authors: Y
authors: Hosoya
authors: K
authors: K
authors: Aritomi
authors: G
authors: G
authors: Goto
mesh_terms: D000818:Animals; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000379:methods*; D004285:Dogs; D005069:Evaluation Studies as Topic; D005460:Fluorides, Topical; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D018030:Silver Compounds
chemical_list: D005460:Fluorides, Topical; D000644:Quaternary Ammonium Compounds; D018030:Silver Compounds; C024633:silver diamine fluoride