Antiradiation properties of alpha tocopherol, anthocyans, and pyracetam administered combined as a pretreatment course.
The effects of an pretreatment course (2 x 5 days) combining vitamin E 20 mg/kg, anthocyans 50 mg/kg, and pyracetam 200 mg/kg on animal survival after lethal irradiation (8 Gy) and blood formation after sublethal irradiation (6 Gy) were studied in mice. Assessments were based on records of an integral criterion, 30-day survival, of spleen weight and cellularity, and of bone-marrow cellularity. Pretreatment with the mixture distinctly raised survival rate (50%) in the protected population. The effect observed was shown to result from potentiating interactions between mixture components. Blood-forming organs experienced less radiation damage, and recovery processes in them were stimulated.
Minkova
M
M
Research Institute of Nuclear Medicine, Radiobiology and Radiation Hygiene, Medical Academy, Sofia, Bulgaria.
Drenska
D
D
Pantev
T
T
Ovcharov
R
R
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000502:physiology; D004359:Drug Therapy, Combination; D006410:Hematopoiesis / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D014810:Vitamin E / Q000494:pharmacology*
D000872:Anthocyanins; D011837:Radiation-Protective Agents; D014810:Vitamin E; D010889:Piracetam