Tamoxifen-associated endometrial carcinoma in postmenopausal breast cancer patients.
Tamoxifen citrate, a nonsteroidal antiestrogen with agonistic properties, is prescribed as an adjuvant to surgery in the treatment of breast cancer. Recent reports have suggested that tamoxifen has an estrogenic property and may be implicated in the development of endometrial carcinomas. Seven new cases are reported to the existing literature in which endometrial carcinomas developed in postmenopausal women on tamoxifen therapy for breast carcinomas.
Malfetano
J H
JH
Department of Obstetrics and Gynecology, Albany Medical College, New York 12208.
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008593:Menopause; D013629:Tamoxifen / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000139:chemically induced*
D013629:Tamoxifen