[Ingestion of diethylstilbestrol during pregnancy. Its responsibility in the testicular feminization syndrome].
We report the cases of two women who had testicular feminization with remnants of Müllerian ducts and whose mothers had received diethylstilbestrol (DES) during the first trimester of pregnancy. At laparotomy, masses were removed which had the microscopic appearances of testes and Fallopian tubes, and were confirmed as such at histology. There were three possible explanations for these genetic abnormalities: deficient antimüllerian hormone (AMH) secretion (or lack of sensitivity of Müllerian ducts to AMH); early testicular descent with regression of Müllerian ducts beyond the efficacy margin of AMH; exposure to DES in utero during the first trimester of pregnancy. In these two women, the most likely explanation seems to be the last one.
Chryssicopoulos
A
A
Département de Gynécologie et d'Obstétrique de l'Université d'Athènes, Hôpital Areteion, Grèce.
Kondi-Parhitis
A
A
Kairi
D
D
Vasiliadis
T
T
Maragoudakis
A
A
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology; D000728:Androgens / Q000378:metabolism; D054304:Anti-Mullerian Hormone; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000378:metabolism; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000503:physiopathology; D011247:Pregnancy; D013577:Syndrome; D013735:Testicular Hormones / Q000378:metabolism
D000728:Androgens; D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D004054:Diethylstilbestrol; D054304:Anti-Mullerian Hormone
Prise de diéthylstilbestrol pendant la grossesse. Sa responsabilité dans le syndrome du testicule féminisant.