title: Chicken atrial natriuretic peptide (chANP) and its secretion.
abstract: An immunohistochemical study using antiserum raised against synthetic chicken natriuretic polypeptide was used to investigate the distribution of this peptide in the chicken heart. Immunoreactive cells, both in the atrial and ventricular walls, were identified by electron microscopy, and electron-dense granules in the atrial and ventricular cardiocytes were revealed to be storage sites of the peptide. The electron-dense material, thought to be the peptide, was found in the sarcoplasmic reticulum, and it is suggested that a secretory pathway of the peptide through the latter to extracellular space, may be present, in addition to an exocytotic one.
authors: Third Division of Internal Medicine, Miyazaki Medical College, Japan.
authors: H
authors: H
authors: Toshimori
authors: K
authors: K
authors: Toshimori
authors: N
authors: N
authors: Minamino
authors: K
authors: K
authors: Kangawa
authors: C
authors: C
authors: Oura
authors: S
authors: S
authors: Matsukura
authors: H
authors: H
authors: Matsuo
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D002642:Chick Embryo; D002645:Chickens; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D006321:Heart / Q000196:embryology; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D009320:Atrial Natriuretic Factor