Neuropathology of epilepsy.
The neuropathology of symptomatic and idiopathic epilepsy is presented. New methods of investigation have disclosed that more cases of epilepsy are symptomatic--even hippocampal sclerosis is now detectable in vivo by MR-scan. It still remains to be defined whether hippocampal sclerosis is the cause or the effect of epilepsy. The present survey focusses upon the delineation of hippocampal neuron loss with a critical discussion of various hypotheses drawn from various human and experimental studies. In particular the phenomenon of selective and delayed neuron loss are explored with regard to future neurosurgical approaches.
Dam
A M
AM
Neurological Research Laboratory, University Hospital Hvidovre Copenhagen, Denmark.
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000601:surgery; D001927:Brain Diseases / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002531:Cerebellum / Q000473:pathology / Q000601:surgery; D002540:Cerebral Cortex / Q000473:pathology / Q000601:surgery; D004828:Epilepsies, Partial / Q000473:pathology* / Q000601:surgery; D006624:Hippocampus / Q000473:pathology / Q000601:surgery; D006801:Humans; D009474:Neurons / Q000473:pathology