[Tissue penetration of single-dose cefotetan used for antibiotic prophylaxis in colorectal surgery].
Pharmacokinetics and tissue penetration of cefotetan were studied after a single injection of 2 g for antibiotic prophylaxis in colo-rectal surgery. Beta half-life was 4.3 +/- 1 h, total body clearance was 0.74 +/- 0.2 ml/kg/min and volume of distribution was 270 +/- 76 ml/kg. At time of laparotomy, cefotetan concentration was 14.2 +/- 7 micrograms/g in abdominal wall fat and 16.4 +/- 1 micrograms/g in epiploic fat. In the colonic wall, cefotetan concentration was 33.3 +/- 16 micrograms/g. At time of abdominal closure, cefotetan concentrations were 6.3 +/- 3 micrograms/g in the abdominal wall fat and 6.1 +/- 4 micrograms/g in the epiploic fat.
Martin
C
C
Département d'Anesthésie-Réanimation, Hôpital Sainte-Marguerite, Marseille.
Mallet
M N
MN
Lambert
D
D
Brun
J P
JP
Yrieix
C
C
Bruguerolle
D
D
Sastre
B
B
D000009:Abdominal Muscles; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D015313:Cefotetan / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010537:Peritoneum; D011292:Premedication; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D015610:Serum Bactericidal Test
D015313:Cefotetan
Pénétration tissulaire du céfotétan utilisé en dose unique pour une antibioprophylaxie en chirurgie colorectale.