Sensitivity of in vivo X-ray fluorescence determination of skeletal lead stores.
Eighteen patients with known past occupational lead exposure underwent parenteral diagnostic chelation with ethylenediaminetetraacetic acid and x-ray fluorescent determination of in vivo skeletal lead stores at the distal styloid process of the ulna and at the temporal base bone using a cobalt 57 source and measuring lead Ka x-rays. X-ray fluorescent lead measurements in both locations correlated with results of diagnostic chelation. Using a post-chelation urinary excretion of greater than 600 micrograms lead/24 h as the definition of "high-" lead stores, sensitivity of x-ray fluorescence at the wrist and temple was 56% and 39%, respectively.
Sokas
R K
RK
Department of Medicine, George Washington University, Washington, D.C.
Besarab
A
A
McDiarmid
M A
MA
Shapiro
I M
IM
Bloch
P
P
D001842:Bone and Bones / Q000737:chemistry*; D004492:Edetic Acid; D004781:Environmental Exposure; D006801:Humans; D007854:Lead / Q000032:analysis* / Q000652:urine; D007855:Lead Poisoning / Q000175:diagnosis / Q000378:metabolism*; D013052:Spectrometry, X-Ray Emission
D007854:Lead; D004492:Edetic Acid