[The characteristics of the localization of induced ruptures in human chromosomes].
Levels of spontaneous and of C-mitomycine and cyclophosphane-induced chromosome aberrations are determined among the persons not subject to professionally industrial hazards. It has been revealed that in all the experimental series the aberration rate in those, who carried extreme polymorphic variants, was much higher compared to those without these variants in their karyotypes. Among the persons with the above extreme versions, the impact of chromosome ruptures is stronger in the vicinity of the structural heterochromatin. Possible causes of the discovered phenomenon are discussed.
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D000293:Adolescent; D000328:Adult; D000477:Alkylating Agents / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000187:drug effects / Q000648:ultrastructure; D002885:Chromosomes, Human, Pair 16 / Q000187:drug effects / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000187:drug effects / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000494:pharmacology; D006570:Heterochromatin / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011110:Polymorphism, Genetic / Q000187:drug effects
D000477:Alkylating Agents; D006570:Heterochromatin; D008937:Mitomycins; D016685:Mitomycin; D003520:Cyclophosphamide
Osobennosti lokalizatsii indutsirovannykh razryvov v khromosomakh cheloveka.