title: [Subcutaneous nodules and sensitivity to aluminum in patients undergoing hyposensitivity immunotherapy].
abstract: Hypersensitivity reactions to aluminium are very rate. Sensitization has been reported to occur during continuous application of aluminium-containing antiperspirants or by aluminium adjuvants in vaccines and hyposensitization immunotherapy. We report 5 patients who developed persistent and itching subcutaneous nodules following immunotherapy. Histologically, the nodules showed a granulomatous reaction consistent with delayed hypersensitivity to aluminium. Patch tests with 2% aluminium chloride in water were positive in three patients, and positive results of patch test with other metals (nickel, cobalt) were frequently associated.
authors: Servicio de Dermatología, Hospital de la Santa Cruz y San Pablo, Barcelona.
authors: V
authors: V
authors: García-Patos
authors: A
authors: A
authors: Alomar
authors: R
authors: R
authors: Lleonart
authors: A
authors: A
authors: Cistero
authors: X
authors: X
authors: Matias-Guiu
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000009:adverse effects*; D001706:Biopsy; D003888:Desensitization, Immunologic; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012882:Skin Tests
chemical_list: D000536:Aluminum Hydroxide
vernacular_title: Nódulos subcutáneos y sensibilidad al aluminio en pacientes con inmunoterapia hiposensibilizante.