Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics.
Insulin tolerance test was done to assess the insulin sensitivity in a group of untreated non insulin dependent diabetic subjects before and after sulfonylurea (tolbutamide, glibenclamide, glipizide) therapy. The parameters studied were KITT, slope of the blood glucose fall, summation values, and area under the curve of glucose response. All the three commonly used sulphonylurea drugs improved insulin sensitivity after 4 weeks of therapy.
Khandekar
S
S
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Sethi
B K
BK
Dash
R J
RJ
D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005913:Glipizide / Q000627:therapeutic use; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D013997:Time Factors; D014044:Tolbutamide / Q000627:therapeutic use
D001786:Blood Glucose; D013453:Sulfonylurea Compounds; D014044:Tolbutamide; D005905:Glyburide; D005913:Glipizide