Calcium channel blockers and terbutaline--a positive interaction.
The role of two calcium channel blockers, nifedipine and verapamil was investigated in patients of bronchial asthma. Both the drugs given orally produced an insignificant rise in PEFR, FEF25-75% and FEV1. Given along with terbutaline, however, these drugs produced significantly greater increase in PEFR, FEF25-75% and FEV1 as compared to patients receiving terbutaline alone. The two calcium channel blockers also inhibited the terbutaline induced tremors and palpitation.
Sharma
T N
TN
Hospital for Chest and Tuberculosis, Jaipur.
Gulati
R
R
Gupta
P R
PR
Goyal
R L
RL
Gupta
S D
SD
Bhatnagar
M
M
D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use; D015656:Respiratory Mechanics / Q000187:drug effects; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D014700:Verapamil; D009543:Nifedipine; D013726:Terbutaline