Endotoxin, PAF and arterial thrombosis.
Using an optoelectronic device, we demonstrated that endotoxin modulates platelet-activating factor (PAF)-induced arterial thrombosis in a mesenteric artery of the guinea-pig. Indeed, topical superfusion by PAF induces the generation of platelet-vessel wall interactions, invariably followed by thrombus formation. A low dose of endotoxin markedly increased, while a high dose significantly reduced thrombus formation. The reducing effect of the high dose can be completely offset by indometacin, indicating the involvement of prostaglandin I2.
Bourgain
R H
RH
Laboratory of Physiology and Physiopathology, Free University of Brussels, Belgium.
Andries
R
R
Braquet
P
P
D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage* / Q000633:toxicity; D011464:Epoprostenol / Q000502:physiology; D006168:Guinea Pigs; D007213:Indomethacin / Q000008:administration & dosage; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000209:etiology / Q000473:pathology; D010972:Platelet Activating Factor / Q000008:administration & dosage* / Q000502:physiology; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology
D004731:Endotoxins; D010972:Platelet Activating Factor; D011464:Epoprostenol; D007213:Indomethacin