Abnormal embryonic heart rate pattern in early pregnancy associated with Down's syndrome.
The case history of a 35-year-old woman with a pregnancy following IVF treatment is presented. Transvaginal sonography revealed an abnormal pattern of the embryonic heart rate between 28 and 50 days following follicular aspiration. At term, a male infant with the characteristics of Down's syndrome was born. The diagnosis was confirmed by chromosome analysis. The implications of this observation are discussed.
Schats
R
R
Department of Obstetrics and Gynaecology/IVF, Diaconessenhuis, Voorburg, The Netherlands.
Jansen
C A
CA
Wladimiroff
J W
JW
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004314:Down Syndrome / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007621:Karyotyping; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D011247:Pregnancy; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D008596:Menotropins; D005640:Follicle Stimulating Hormone