title: [Tissue penetration of single-dose cefotetan used for antibiotic prophylaxis in colorectal surgery].
abstract: Pharmacokinetics and tissue penetration of cefotetan were studied after a single injection of 2 g for antibiotic prophylaxis in colo-rectal surgery. Beta half-life was 4.3 +/- 1 h, total body clearance was 0.74 +/- 0.2 ml/kg/min and volume of distribution was 270 +/- 76 ml/kg. At time of laparotomy, cefotetan concentration was 14.2 +/- 7 micrograms/g in abdominal wall fat and 16.4 +/- 1 micrograms/g in epiploic fat. In the colonic wall, cefotetan concentration was 33.3 +/- 16 micrograms/g. At time of abdominal closure, cefotetan concentrations were 6.3 +/- 3 micrograms/g in the abdominal wall fat and 6.1 +/- 4 micrograms/g in the epiploic fat.
authors: Département d'Anesthésie-Réanimation, Hôpital Sainte-Marguerite, Marseille.
authors: C
authors: C
authors: Martin
authors: M N
authors: MN
authors: Mallet
authors: D
authors: D
authors: Lambert
authors: J P
authors: JP
authors: Brun
authors: C
authors: C
authors: Yrieix
authors: D
authors: D
authors: Bruguerolle
authors: B
authors: B
authors: Sastre
mesh_terms: D000009:Abdominal Muscles; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D015313:Cefotetan / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010537:Peritoneum; D011292:Premedication; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D015610:Serum Bactericidal Test
chemical_list: D015313:Cefotetan
vernacular_title: Pénétration tissulaire du céfotétan utilisé en dose unique pour une antibioprophylaxie en chirurgie colorectale.