title: Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
abstract: Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
authors: Department of Pharmacology Kobe Women's College of Pharmacy, Japan.
authors: Y
authors: Y
authors: Sugimoto
authors: I
authors: I
authors: Kimura
authors: J
authors: J
authors: Yamada
authors: Y
authors: Y
authors: Watanabe
authors: N
authors: N
authors: Takeuchi
authors: K
authors: K
authors: Horisaka
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D008297:Male; D051379:Mice; D012701:Serotonin / Q000009:adverse effects / Q000494:pharmacology*; D013311:Streptozocin / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012701:Serotonin; D013311:Streptozocin; D005947:Glucose