[A clinico-pathogenetic assessment of the membrane structure and functions of the peripheral blood lymphocytes in insulin-dependent diabetes mellitus].
The structure and functions of lymphocyte membranes with characterization of their phospholipid composition, lipid peroxidation intensity (LP), activity of membranous ATPases and a type of the immune status were investigated in patients with insulin dependent diabetes mellitus. The results obtained were indicative of considerable differences (LP) in the lymphocytes of these patients as compared to those of healthy controls. LP intensity showed correlation with change in the ratio of phospholipid fractions and change in ATPase activity. In complicated insulin dependent diabetes mellitus destabilization of lymphocyte cell membranes and disturbance of transmembranous transport were more marked than in uncomplicated disease. The structure and functions of the membranes of immunocompetent cells, a degree of carbohydrate metabolic decompensation and the presence of complications determined an immune response type.
Nelaeva
A A
AA
Kashuba
E A
EA
Kardakov
Iu I
IuI
D000328:Adult; D002462:Cell Membrane / Q000276:immunology / Q000473:pathology / Q000502:physiology; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000209:etiology / Q000276:immunology; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000209:etiology / Q000276:immunology; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology / Q000276:immunology; D006801:Humans; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology* / Q000502:physiology; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D011704:Pyelonephritis / Q000097:blood / Q000209:etiology / Q000276:immunology
D010743:Phospholipids
Kliniko-patogeneticheskaia otsenka struktury i funktsiĭ membran limfotsitov perifericheskoĭ krovi pri insulinzavisimom sakharnom diabete.