Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
Sugimoto
Y
Y
Department of Pharmacology Kobe Women's College of Pharmacy, Japan.
Kimura
I
I
Yamada
J
J
Watanabe
Y
Y
Takeuchi
N
N
Horisaka
K
K
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D008297:Male; D051379:Mice; D012701:Serotonin / Q000009:adverse effects / Q000494:pharmacology*; D013311:Streptozocin / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D012701:Serotonin; D013311:Streptozocin; D005947:Glucose