The effect of triethanolamine application on anthralin-induced inflammation and therapeutic effect in psoriasis.
Twenty patients with chronic plaque psoriasis were treated with short-contact anthralin followed by 10% triethanolamine application to one side of the body and aqueous cream to the other. Anthralin-induced inflammation was inhibited on the triethanolamine-treated side whereas anthralin therapy had to be temporarily stopped in 18 patients on the aqueous cream side because of anthralin-induced inflammation. Therapeutic response was not different in the two sides. This study shows that anthralin-induced inflammation and its therapeutic effect can be dissociated.
Ramsay
B
B
Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.
Lawrence
C M
CM
Bruce
J M
JM
Shuster
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D003875:Drug Eruptions / Q000188:drug therapy* / Q000209:etiology; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D012880:Skin Pigmentation / Q000187:drug effects; D013997:Time Factors
D004983:Ethanolamines; C009546:triethanolamine; D000875:Anthralin