Alteration of aliphatic lipid proton NMR linewidths by malignant tumors in guinea pigs.
Water-suppressed proton nuclear magnetic resonance spectroscopy was used to observe plasma lipoprotein lipid methyl and methylene resonances from guinea pigs which had been injected with viable or heat-killed line 1 or line 10 tumor cells or sterile oil. It was shown that the widths of these resonances became significantly sharper as the number of tumor cells grew. Plasma from tumor-free control animals showed no change in the NMR linewidths. It is concluded that the changes observed reflect a specific host response to viable tumor cells, and in these models there is a reciprocal relationship between the number of viable tumor cells and the linewidths of plasma lipoprotein methyl and methylene resonances.
Fossel
E T
ET
Department of Radiology, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
Dvorak
H F
HF
Carr
J M
JM
McDonagh
J
J
D000818:Animals; D001650:Bile Duct Neoplasms / Q000097:blood / Q000175:diagnosis*; D006168:Guinea Pigs; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy
D008074:Lipoproteins