Transmural non-homogeneity of calcium-induced heart injury.
The Ca paradox resulted in marked inhibition, up to disappearance, of histochemically studied enzyme activities (SDH, LDH, beta-HBDH, phosphorylase and ATPase) in the subepicardial layer of the myocardium. In the subendocardial region there was only a small decrease. These transmural differences correlated well with ultrastructural changes. It is assumed that the heterogeneity in transmural distribution of injury is the result of transmural differences in coronary flow.
Tribulová
N
N
Institute of Experimental Surgery, Slovak Academy of Sciences, Bratislava.
Slezák
J
J
Ravingerová
T
T
Ziegelhöffer
A
A
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology*; D005260:Female; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D015427:Reperfusion Injury / Q000201:enzymology*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D013385:Succinate Dehydrogenase; D006005:Phosphorylases; D000251:Adenosine Triphosphatases; D002118:Calcium