The effect of thyroid hormone on the activities of lactase in the culture of fetal rat intestine.
The effects of thyroid hormone on lactase activities were studied in vitro organ culture of fetal rat intestine. Triiodothyronine inhibited lactase activities regardless the presence of dexamethasone. Also triiodothyronine decreased lactase activities when added after dexamethasone increased lactase activities. Our results suggest that thyroid hormone may have a role in the maturational changes of lactase activities during weaning.
Shimizu
K
K
Department of Pediatrics, Osaka Medical School, Japan.
Nose
O
O
Okada
S
S
D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D007583:Jejunum / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D043322:Lactase; D051381:Rats; D014284:Triiodothyronine / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D014284:Triiodothyronine; D003907:Dexamethasone; D043322:Lactase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase