Phospholipid peroxidation induced by the catechol-Fe3+(Cu2+) complex: a possible mechanism of nigrostriatal cell damage.
Ferric or cupric ions significantly promoted a peroxidative cleavage of unsaturated phospholipids in liposomes in vitro after coordinating with dopa and dopamine. Either alpha-tocopherol or desferrioxamine completely abolished the dopa-Fe3+ complex-induced phospholipid peroxidation, while superoxide dismutase, catalase, or sodium benzoate did not. A ferroxidase, ceruloplasmin, significantly inhibited the lipid peroxidation induced by the dopa-Fe3+ complex, indicating the importance of the reduction of the iron moiety in the complex for the lipid peroxidation. A possible mechanism of dopa-Fe3+ complex-induced phospholipid peroxidation is that oxene complexes, such as Fe(V) = O and Fe(IV) = O, produced abstract hydrogen atoms in unsaturated phospholipids to initiate lipid peroxidation.
Sotomatsu
A
A
College of Medical Care and Technology, Gunma University, Maebashi, Japan.
Nakano
M
M
Hirai
S
S
D000818:Animals; D002412:Cations; D002570:Ceruloplasmin / Q000494:pharmacology; D003342:Corpus Striatum / Q000473:pathology; D003676:Deferoxamine / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D005290:Ferric Compounds / Q000494:pharmacology*; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D013378:Substantia Nigra / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology
D002412:Cations; D005227:Fatty Acids; D005290:Ferric Compounds; D010743:Phospholipids; C066891:iron(III)-dopa complex; D014810:Vitamin E; D004295:Dihydroxyphenylalanine; D002570:Ceruloplasmin; D003676:Deferoxamine