title: Antibody response to preS1 in hepatitis-B-virus-induced liver disease and after immunization.
abstract: Antibodies to the pre-S1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1% of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13% of the HBsAg+ sera obtained before recovery and in 37% of the sera obtained after recovery. Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies.
authors: Institut de Virologie de Tours et Laboratoire de Microbiologie, Faculté de Pharmacie, France.
authors: P
authors: P
authors: Coursaget
authors: Y
authors: Y
authors: Buisson
authors: C
authors: C
authors: Bourdil
authors: B
authors: B
authors: Yvonnet
authors: C
authors: C
authors: Molinié
authors: M T
authors: MT
authors: Diop
authors: J P
authors: JP
authors: Chiron
authors: O
authors: O
authors: Bao
authors: I
authors: I
authors: Diop-Mar
mesh_terms: D000328:Adult; D002353:Carrier State / Q000276:immunology; D002648:Child; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology; D011498:Protein Precursors / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011498:Protein Precursors; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines; C050806:presurface protein 1, hepatitis B surface antigen; C050807:presurface protein 2, hepatitis B surface antigen