CD4+ cytolytic T cell clone confers protection against murine malaria.
A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
Tsuji
M
M
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010.
Romero
P
P
Nussenzweig
R S
RS
Zavala
F
F
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D016782:Apicomplexa / Q000276:immunology / Q000302:isolation & purification; D015704:CD4 Antigens / Q000032:analysis*; D002999:Clone Cells / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D005260:Female; D007111:Immunity, Cellular / Q000276:immunology / Q000502:physiology; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei / Q000276:immunology / Q000302:isolation & purification; D013154:Spleen / Q000166:cytology / Q000469:parasitology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015704:CD4 Antigens; D007376:Interleukin-2; D007371:Interferon-gamma