A convenient synthesis of trans-3'-hydroxycotinine, a major nicotine metabolite found in the urine of tobacco users.
trans-3'-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3'-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.
Desai
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Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595.
Amin
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D003367:Cotinine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013237:Stereoisomerism
C001381:hydroxycotinine; D003367:Cotinine