Trisomy 21 in transient myeloproliferative disorder.
Transient leukemia in phenotypically normal children is rare. A newborn child in whom fever and tachypnea developed at age 2 days had a white blood cell count of 20.1 x 10(9)/L and many abnormal blast cells. Chromosome analysis of spontaneously dividing cells from the blood showed these to have trisomy 21, and 80% of cells in the marrow were also trisomic. No trisomic cells were present in skin fibroblast cultures. At age 6 months, at which time the blood film appeared normal, trisomic cells were no longer present.
Faed
M J
MJ
Department of Pathology, University of Dundee, Scotland.
Robertson
J
J
Todd
A S
AS
Sivakumaran
M
M
Tarnow-Mordi
W O
WO
D002478:Cells, Cultured; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009196:Myeloproliferative Disorders / Q000235:genetics*