Age-related increase in c-fos expression in the sympathetic neurons of the rat superior cervical ganglion.
C-fos expression was studied immunocytochemically in sympathetic neurons of the rat superior cervical ganglion (SCG). Fos-like immunoreactivity was confined to the principal neurons of the ganglion and was exclusively localized within their nuclei. In 2-month-old rats, the immunoreactivity was detected in 1.2% of the principal neurons with a density of 4.95 Fos-positive cells/mm2 of ganglion area. This proportion increased with age and reached a value which was 6.5-fold higher in the 26-month-old rats than that in the young adult. A density of 24.5 Fos-positive cells/mm2 of ganglion area was seen in the 26-month-old animals. The age-enhanced c-fos expression suggests that Fos may be involved in regulation of the genetic events associated with the adaptive changes in neuronal activity of the sympathetic ganglion during aging.
Yang
G A
GA
Department of Public Health, Tampere University, Finland.
Koistinaho
J
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005455:Fluorescent Antibody Technique; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000378:metabolism*; D015870:Gene Expression; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos; D051381:Rats; D011919:Rats, Inbred Strains
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos