title: Effect of adrenalectomy and glucocorticoid treatment on the levels of an insulin-sensitive glycosyl-phosphatidylinositol in isolated rat hepatocytes.
abstract: Insulin resistance caused by dexamethasone administration to rats was accompanied by a marked decrease in the hepatocyte content of an insulin-sensitive glycosyl-phosphatidylinositol, as well as by a blockade of its hydrolysis in response to this hormone. In contrast, bilateral adrenalectomy provoked a significant increase of the cellular glycosyl-phosphatidylinositol levels. Under all the assayed metabolic conditions, a close direct correlation was established between the basal content of this compound and the number of insulin receptors present in the isolated hepatocytes.
authors: Servicio de Endocrinología Experimental, Hospital Puerta de Hierro, Universidad Autónoma de Madrid, Spain.
authors: M A
authors: MA
authors: Cabello
authors: J A
authors: JA
authors: Sánchez-Arias
authors: A
authors: A
authors: Liras
authors: J M
authors: JM
authors: Mato
authors: J E
authors: JE
authors: Felíu
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D006017:Glycolipids / Q000378:metabolism*; D017261:Glycosylphosphatidylinositols; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism
chemical_list: D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D007328:Insulin; D010716:Phosphatidylinositols; D003907:Dexamethasone; D011972:Receptor, Insulin