title: Co-localization of putative vasopressin receptors and vasopressinergic neurons in rat hypothalamus.
abstract: Vasopressin and oxytocin are synthesized by neurons in the paraventricular and supraoptic nuclei of hypothalamus. Dense concentrations of vasopressin binding sites have also been localized in these nuclei. Using a vasopressin anti-idiotypic antiserum, a dual immunocytochemical labeling procedure has been employed to elucidate the distribution of putative vasopressin receptors in anatomical relation to vasopressin and oxytocin immunoreactive cells in rat brain. Putative vasopressin receptors are observed in relation to magnocellular neurons in hypothalamus that are vasopressin immunoreactive. They do not appear to be associated with parvocellular vasopressinergic cells or oxytocin immunoreactive neurons. The presence of these presumed autoreceptors would support evidence that vasopressin may autoregulate the activity of magnocellular vasopressinergic neurons in hypothalamus.
authors: Neuroendocrine Unit, University of Rochester School of Medicine, NY 14642.
authors: D J
authors: DJ
authors: Berlove
authors: D T
authors: DT
authors: Piekut
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D008297:Male; D009474:Neurons / Q000737:chemistry*; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry* / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000032:analysis*; D017483:Receptors, Vasopressin; D013495:Supraoptic Nucleus / Q000737:chemistry* / Q000166:cytology; D014667:Vasopressins / Q000502:physiology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D014667:Vasopressins