Adequate sodium balance and cardiovascular stability.
To evaluate the sodium balance in haemodialysis and haemodiafiltration a computerised model has been developed, which calculates net sodium balance from the infusive, diffusive, and convective sodium fluxes for each minute of treatment, updating the value of plasma water ionised sodium concentration at each step. Using this model and assuming constant body-weight, treatment time, and net ultrafiltration, different haemodialysis and haemodiafiltration treatments, with different dialysate sodium concentrations, sodium infusions, and pre-treatment plasma water sodium concentrations were simulated. The results show that a less negative sodium balance is almost always obtained during haemodiafiltration than in haemodialysis, when using the same dialysate sodium concentrations. Therefore, since sodium is an important factor in cardiovascular stability, it is necessary to match sodium balance with other operational parameters when comparing haemodiafiltration with haemodialysis.
Locatelli
F
F
Division of Nephrology, Hospital of Lecco, Italy.
Ponti
R
R
Pedrini
L
L
Di Filippo
S
S
D002319:Cardiovascular System / Q000503:physiopathology*; D003198:Computer Simulation; D006440:Hemofiltration; D006801:Humans; D007700:Kinetics; D008955:Models, Cardiovascular; D006435:Renal Dialysis; D012964:Sodium / Q000378:metabolism*
D012964:Sodium