Influence of mannitol on the penetration of teicoplanin into infected CSF of experimental Staphylococcus aureus meningitis of rabbits.
We investigated the influence to mannitol injections on the teicoplanin penetration into CSF in experimental bacterial meningitis of rabbits. Experimental bacterial meningitis was obtained by intracisternal inoculation of 10(7) cfu of methicillin resistant Staphylococcus aureus. The experimental bacterial meningitis was controlled 18 h later by cisternal puncture. At this time (T0) mannitol (solution for injection 20%) was injected (bolus), at a dosage of 3 ml/kg, into the carotid arteria. Immediately after the previous bolus, teicoplanin was administered through the same line over 5 min, at a dosage of 5 mg/kg. Cerebrospinal fluid was obtained 30 min and 2 h after injection was completed, and serum samples were obtained at the same time. Results were (mg/l) in cerebrospinal fluid: (Table; see text) (* p less than 0.05 comparing the two regimens at T0 + 2 h, and comparing regimen teicoplanin + mannitol infusion at T0 + 30 sec and + 2 h). This is very promising for the treatment of methicillin resistant Staphylococcus aureus bacterial meningitits and should support further investigations.
Manquat
G
G
Clinique Médicale et des Maladies Infectieuses, Centre Hospitalier Régional Universitaire, Grenoble, France.
Stahl
J P
JP
Pelloux
I
I
Micoud
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006020:Glycopeptides / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007269:Injections, Intra-Arterial; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D017334:Teicoplanin
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D008353:Mannitol; D017334:Teicoplanin