[Possibilities for increasing the elimination rate of Bonnecor].
Bonnecor is excreted in rats both via urine (3/4) and bile (1/4). It was the aim of this study to find out suitable methods for detoxication of a poisoning with this antiarrhytmic drug. In vivo methods intended to enhance the renal excretion of Bonnecor (forced diuresis, changes in urinary pH-values, peritoneal dialysis) are not qualified for therapeutically relevant increase of Bonnecor elimination. Relating to this Bonnecor is quite comparable with other antiarrhythmic drugs or dibenzazepine derivatives. The hemoperfusion can be recommended for the therapy of a Bonnecor overdosage as a propping up of symptomatic methods of intensive care, which are precendentally indicated. Therefore the therapy of a Bonnecor poisoning seems to be more promising compared to intoxications with other antiarrhythmics. Among the adsorbents tested, the resin Wofatit UH91 is most suitable to remove Bonnecor from the organism. If hemoperfusion equipments are not available, hemodialysis can also be used for acceleration of Bonnecor elimination, although its effectivity is only one third of that of hemoperfusion.
Fleck
C
C
Abteilung für Pharmakologie, Bereiches Medizin der Friedrich-Schiller-Universität Jena.
Schilder
L
L
Schulze
U
U
Pfister
M
M
Stein
G
G
Landmann
H
H
Schwachula
G
G
Bräunlich
H
H
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001646:Bile / Q000378:metabolism; D003984:Dibenzazepines / Q000493:pharmacokinetics* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000378:metabolism* / Q000628:therapy; D005665:Furosemide / Q000008:administration & dosage; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D006464:Hemoperfusion / Q000379:methods; D006863:Hydrogen-Ion Concentration; D008297:Male; D008353:Mannitol / Q000008:administration & dosage; D008657:Metabolic Clearance Rate / Q000502:physiology; D010530:Peritoneal Dialysis / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D006435:Renal Dialysis / Q000379:methods
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; D008353:Mannitol; D005665:Furosemide; C048166:tiracizine
Möglichkeiten zur Beschleunigung der Elimination von Bonnecor.