Effect of aminoglycoside antibiotics on the autolytic enzyme of Streptomyces griseus.
The isolated cell wall of Streptomyces griseus 52-1 strain labelled with fluorescein isothiocyanate (FITC) and containing wall-bound autolytic enzyme was lysed as a function of different cations. The autolysis was accelerated by aminoglycoside antibiotics (streptomycin and the structurally closely related neomycin) which have a polycationic character. Since this strain is a streptomycin producer it is suggested that streptomycin may have a regulatory function on autolysis.
Szabó
I
I
Institute of Biology, University Medical School, Debrecen, Hungary.
Penyige
A
A
Barabás
G
G
Barabás
J
J
D000581:Amidohydrolases / Q000187:drug effects* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001433:Bacteriolysis; D002473:Cell Wall / Q000187:drug effects / Q000201:enzymology; D002850:Chromatography, Gel; D004789:Enzyme Activation / Q000187:drug effects; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D009355:Neomycin / Q000494:pharmacology; D013305:Streptomyces griseus / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D013307:Streptomycin / Q000494:pharmacology; D013861:Thiocyanates
D000900:Anti-Bacterial Agents; D005452:Fluoresceins; D013861:Thiocyanates; D000581:Amidohydrolases; D009355:Neomycin; D016650:Fluorescein-5-isothiocyanate; D013307:Streptomycin