title: The effect of aging on the D1 dopamine receptors in human frontal cortex.
abstract: Dopaminergic pathways to the cerebral cortex may be involved in cognitive function. We examined the effect of aging on the D1 dopamine receptors, and their high-agonist affinity (RH) sites, in postmortem human frontal cortex (n = 32; age range, 19-88 years). With aging, there was a significant decrease in the densities of the D1 dopamine receptors, and their RH sites, in human frontal cortex. The age-related reduction of cortical dopaminergic neurotransmission might contribute to the decline in cognitive abilities of elderly persons.
authors: Department of Neurology, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
authors: J
authors: J
authors: de Keyser
authors: J P
authors: JP
authors: De Backer
authors: G
authors: G
authors: Vauquelin
authors: G
authors: G
authors: Ebinger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001552:Benzazepines / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000378:metabolism*; D017447:Receptors, Dopamine D1; D014316:Tritium
chemical_list: D001552:Benzazepines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D014316:Tritium