Inhibition of a chicken B-cell lymphoma by suppressor T-cells from agammaglobulinemic chickens.
The growth of B-cell lymphoma, LSCC-RP9, in culture was inhibited by spleen cells from bursa-immunized agammaglobulinemic (A-gamma) chickens. This inhibition was mediated by suppressor T-cells. The growth of transplantable LSCT-RP6 B-cell lymphoma was suppressed in A-gamma chickens, while that of the control SPCT-RP11 T-cell tumor was not affected. Furthermore, the incidence and growth of the LSCT-RP6 tumor in normal recipients were decreased when it was co-transplanted with spleen cells from bursa immunized A-gamma chickens. The results suggest that suppressor T-cells inhibit the growth of B-cell lymphoma.
Chi
D S
DS
Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.
Sharma
J M
JM
D000361:Agammaglobulinemia / Q000276:immunology*; D000818:Animals; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens; D007114:Immunization; D016219:Immunotherapy, Adoptive; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000517:prevention & control*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014407:Tumor Cells, Cultured