title: [Effectiveness of hemodialysis in a case of acute methotrexate poisoning].
abstract: In a case of acute intoxication with high-dose methotrexate, a kinetic study of plasma methotrexate concentrations enabled the authors to begin treatment with high-permeability membrane haemodialysis combined with intensive folic acid loading before the clinical signs of iatrogenic toxicities developed, and to continue with haemodialysis rather than using other depurative methods. In this case, the post-depuration course was favourable: dermatological signs and febrile pancytopenia regressed within 4 days, and these was no sign of hepatic toxicity.
authors: Département de Cancérologie, CHU Henri-Mondor, Créteil.
authors: E
authors: E
authors: Gauthier
authors: J F
authors: JF
authors: Gimonet
authors: P
authors: P
authors: Piedbois
authors: G
authors: G
authors: Rostoker
authors: C
authors: C
authors: Buisson
authors: A
authors: A
authors: Ben Maadi
authors: B
authors: B
authors: Samyn
authors: A A
authors: AA
authors: Messadi
authors: B
authors: B
authors: Brun
authors: F
authors: F
authors: Feuilhade
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy; D011041:Poisoning / Q000628:therapy*; D006435:Renal Dialysis
chemical_list: D008727:Methotrexate
vernacular_title: Efficacité de l'hémodialyse dans un cas d'intoxication aiguë par le méthotrexate.