title: Increased cell-mediated cytotoxicity against beta-cells in streptozotocin-treated offspring of mother animals with gestational hyperglycaemia.
abstract: The offspring of mother animals with mild gestational hyperglycaemia exhibited basal hyperinsulinism, decreased glucose tolerance and increased susceptibility to streptozotocin diabetes. Following low-dose successive streptozotocin treatment a significantly increased spleen cell cytotoxicity against beta-cells was found in these animals as compared to the offspring of gestational normoglycaemic control mothers. Such increased cell-mediated cytotoxicity, considered as enhanced autoimmune reactivity, was positively correlated to blood glucose levels and negatively correlated to pancreatic insulin contents. Thus, hyperinsulinism, occurring during pre- and neonatal brain organization and produced by gestational hyperglycaemia, is a predisposing teratogenetic risk factor not only for the development of type II, but also of type I diabetes. Thus, it is comprehensible that the prevalence of type I diabetes in children could be decisively reduced by preventing gestational hyperglycaemia in their mothers (Dörner et al., 1985).
authors: Institute of Experimental Endocrinology, Humboldt University Medical School, Berlin, GDR.
authors: G
authors: G
authors: Dörner
authors: E
authors: E
authors: Köhler
authors: J
authors: J
authors: Friedrichs
authors: F
authors: F
authors: Götz
authors: W
authors: W
authors: Rohde
authors: U
authors: U
authors: Kürschner
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D003920:Diabetes Mellitus / Q000209:etiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006946:Hyperinsulinism / Q000150:complications*; D007515:Islets of Langerhans / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D010179:Pancreas / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: D013311:Streptozocin; D005947:Glucose