title: Superoxide anion radical induces lipid phase transitions that mimic temperature-induced phase-transition phenomenon of membrane lipids.
abstract: A biological membrane is shown to undergo lipid-phase transition leading to increased membrane fluidity when exposed to extraneously generated superoxide anion radical. This phase-transition is several folds higher in magnitude when compared to the temperature-induced fluidity change at the transition temperatures. This finding could have significant importance since an altered membrane configuration may involve aspects of biochemistry, biophysics or physiology.
authors.affiliation: School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.
authors.forename: G P
authors.initials: GP
authors.lastname: Kumar
authors.forename: N
authors.initials: N
authors.lastname: Tillo
authors.forename: M
authors.initials: M
authors.lastname: Laloraya
authors.forename: M
authors.initials: M
authors.lastname: Nivsarkar
authors.forename: S
authors.initials: S
authors.lastname: Verma
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000097:blood*; D011817:Rabbits; D013113:Spin Labels; D013481:Superoxides / Q000494:pharmacology*; D013696:Temperature; D013816:Thermodynamics
chemical_list: D003497:Cyclic N-Oxides; D008563:Membrane Lipids; D013113:Spin Labels; D013481:Superoxides; C005072:5-doxylstearic acid