Arrangement of ocular dominance columns in human visual cortex.
The arrangement of the ocular dominance columns in the human primary visual cortex was studied by examining cytochrome oxidase activity in autopsy specimens of occipital lobes obtained from two patients who became blind in one eye before death. By artificially flattening the cortex before processing, it was possible to reconstruct the pattern formed by the ocular dominance columns throughout most of the primary visual cortex. The columns form a mosaic of irregular parallel stripes about 500 microns to 1000 microns wide (right eye column plus left eye column measures 1 to 2 mm), oriented at right angles to the boundary of the primary visual cortex. The columns are wider near the boundary of the primary visual cortex and within the representation of the peripheral visual field, the ocular dominance columns of the ipsilateral eye become fragmented until they disappear altogether at the border of the monocular crescent representation. The arrangement of ocular dominance columns in the human visual cortex is very similar to the pattern reported in the macaque monkey, although the columns in humans are wider.
Horton
J C
JC
Center for Sight, Georgetown University Medical Center, Washington, DC.
Dagi
L R
LR
McCrane
E P
EP
de Monasterio
F M
FM
D000368:Aged; D001766:Blindness / Q000000981:diagnostic imaging; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009799:Ocular Physiological Phenomena; D014057:Tomography, X-Ray Computed; D014793:Visual Cortex / Q000473:pathology*
D003576:Electron Transport Complex IV