Inhibition of rate of tumour growth in rodent species by inoculation of herpesviruses and encephalomyocarditis virus.
Inoculation of herpesviruses and encephalomyocarditis virus into subcutaneous tumours in hamsters and mice reduced the rate of tumour growth compared to untreated tumours or secondary tumours which had arisen following surgical excision of the primary tumour; in addition, survival times were increased in animals whose tumours were inoculated with virus. It is suggested that the role of virus in the modification of tumour growth merits further exploration.
Cowan
M
M
Vaccine Research Foundation, Department of Medical Microbiology, The Medical School, University of Birmingham, England.
Davies
J
J
Brookes
K
K
Billstrom
M
M
McLeish
P
P
Buchan
A
A
Skinner
G R
GR
D000818:Animals; D002455:Cell Division; D006224:Cricetinae; D004686:Encephalomyocarditis virus / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000473:pathology*; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology* / Q000627:therapeutic use; D014779:Virus Replication
D014765:Viral Vaccines