title: Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea.
abstract: The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3-12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM by an ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could be used to evaluate vaccine "take" in rotavirus vaccine trials.
authors.affiliation: Department of Pediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi.
authors.forename: J
authors.initials: J
authors.lastname: Aiyar
authors.forename: M K
authors.initials: MK
authors.lastname: Bhan
authors.forename: N
authors.initials: N
authors.lastname: Bhandari
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: P
authors.initials: P
authors.lastname: Raj
authors.forename: S
authors.initials: S
authors.lastname: Sazawal
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D003968:Diarrhea, Infantile / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007223:Infant; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology*; D012463:Saliva / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M