title: The anticancer effect of antineoplaston A-10 on human breast cancer serially transplanted to athymic mice.
abstract: We report the effects of Antineoplaston A-10 Injection on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice. The intraperitoneal administration of 1/4 LD-50 (50 mg/mouse) of Antineoplaston A-10 Injection every day and 1/2 LD-50 (100 mg/mouse) every other day for 35 days was found to significantly inhibit the growth curve and also the 3H-TdR uptake was inhibited by 73.7% in those given 1/4 LD-50 and by 77.1% in those given 1/2 LD-50. The tumor histology in both groups showed necrosis but no lymphocyte infiltration.
authors.affiliation: 1st Department of Surgery, Kurume University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Koga
authors.forename: Y
authors.initials: Y
authors.lastname: Shintomi
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Kakegawa
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
authors.forename: H
authors.initials: H
authors.lastname: Hara
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D044482:Benzeneacetamides; D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010880:Piperidines / Q000627:therapeutic use*; D010881:Piperidones; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D044482:Benzeneacetamides; D010880:Piperidines; D010881:Piperidones; C052091:antineoplaston A10