title: Sensitivity in vitro of Giardia intestinalis to dyadic combinations of azithromycin, doxycycline, mefloquine, tinidazole and furazolidone.
abstract: The new macrolide antibiotic, azithromycin, produced significant growth inhibition of Giardia intestinalis at 100 micrograms/ml, but adherence inhibition was significant at concentrations as low as 1 microgram/ml for the two strains used in these experiments. The dyadic combinations of azithromycin-furazolidone, doxycycline-mefloquine, doxycycline-tinidazole and mefloquine-tinidazole were synergistic for inhibition of adherence. These results suggest that these dyadic combinations may be worthy of consideration for chemotherapy of recalcitrant giardiasis.
authors.affiliation: Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
authors.forename: A A
authors.initials: AA
authors.lastname: Crouch
authors.forename: W K
authors.initials: WK
authors.lastname: Seow
authors.forename: L M
authors.initials: LM
authors.lastname: Whitman
authors.forename: Y H
authors.initials: YH
authors.lastname: Thong
mesh_terms: D000818:Animals; D017963:Azithromycin; D004318:Doxycycline / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology; D005872:Giardia / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D015767:Mefloquine / Q000494:pharmacology; D014011:Tinidazole / Q000494:pharmacology
chemical_list: D014011:Tinidazole; D005664:Furazolidone; D004917:Erythromycin; D017963:Azithromycin; D004318:Doxycycline; D015767:Mefloquine