[Neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) as serum markers in the diagnosis of bronchial carcinoma].
In 54 patients with untreated, histologically proven lung cancers (18 squamous cell, 15 small cell, 12 large cell carcinomas and 9 adenocarcinomas), the serum antigens NSE and SCC were measured. 43 (71) patients with benign lung diseases served as controls for serum levels of SCC (NSE). With a cut-off level of 2.5 (15.0) ng/ml elevated serum values were observed in 4.6% (4.2%) of the control collectives. We determined the sensitivity of both antigens in the diagnosis of the different histological cancer types. The highest sensitivity of 80% was observed for NSE in patients with small cell cancer, whereas non-small cell cancers were associated with only 11-27% elevated serum concentrations. The sensitivity for SCC was highest in patients with adenocarcinoma (44%) and attained only 33% in squamous cell cancer patients. We could not confirm a selectivity of serum-SCC for squamous cell differentiation in lung cancers. Combined serum determination of SCC and NSE increased the sensitivity in the diagnosis of non-small cell lung cancer but not of small cell cancer compared to the NSE determination alone. The data suggest a correlation of serum SCC levels to the tumour stage in squamous cell carcinoma patients.
Lorenz
J
J
III. Medizinische Klinik, Abteilung Innere Medizin-Pneumologie, Universitätsklinikum Mainz.
Gillmann-Blum
D
D
Jensen
M
M
Kreienberg
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000302:isolation & purification*; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood; D018288:Carcinoma, Small Cell / Q000097:blood; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D012680:Sensitivity and Specificity; D015843:Serpins
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen; D010751:Phosphopyruvate Hydratase
Die Serummarker Neurospezifische Enolase (NSE) und Squamous Cell Carcinoma Antigen (SCC) in der Diagnostik des Bronchialkarzinoms.