Male-mediated behavioral abnormalities.
The assessment of behavioral development in the progeny of males exposed to known mutagenic chemicals is a potentially sensitive endpoint for detecting transmissible abnormalities. A genetic component is demonstrated as these behavioral abnormalities can also be passed on to the F2 generation. In this review, experimental studies exploring transmission of behavioral deficits from paternal exposure to drugs, chemicals and radiation are addressed. Additionally included is a brief synopsis of recent work performed in our laboratory investigating such abnormalities in offspring from male rats exposed to ionizing radiations. The implications of these behavioral endpoints to humans is also discussed.
Lowery
M C
MC
Department of Pathology, Penrose Pathology Group, Colorado Springs, CO 80907-7699.
Au
W W
WW
Adams
P M
PM
Whorton
E B
EB
Legator
M S
MS
D000014:Abnormalities, Drug-Induced; D000016:Abnormalities, Radiation-Induced; D000818:Animals; D001522:Behavior, Animal; D005819:Genetic Markers; D005824:Genetics, Behavioral; D008297:Male; D051379:Mice; D009043:Motor Activity; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D005819:Genetic Markers