Recombinant hirudin displaces human factor Xa from its endothelial binding sites.
Pizzo
S V
SV
Department of Pathology, Duke University Medical Center, Durham, NC 27710.
Friedberg
R C
RC
Sze
P
P
Winant
R
R
Hudson
D
D
Lazar
J M
JM
Johnson
P H
PH
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D015951:Factor Xa / Q000378:metabolism*; D006629:Hirudins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism / Q000494:pharmacology
D006629:Hirudins; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; C045069:factor X receptors; D015951:Factor Xa