Vasodilatory active principles of Sophora flavescens root.
Flavanones vexibinol and kurarinone were isolated from an ethyl acetate extract of Sphora flavescens roots and assayed using isolated rabbit and rat thoracic aorta helical strips. These compounds inhibited KCl and norepinephrine maximum contractions in a concentration-dependent manner in the rat but only KCl contractions in the rabbit. Vexibinol and kurarinone weakly inhibited histamine- and serotonin-induced contractions in the rabbit. The results suggest that these flavanones may inhibit Ca2+ influx through a voltage-dependent Ca2+ channel.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Kobayashi
G
G
Iwamoto
M
M
Chisaka
T
T
Fujimura
H
H
Takaishi
Y
Y
Yoshida
M
M
Tomimatsu
T
T
Tamai
Y
Y
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology*
D015220:Calcium Channels; D005419:Flavonoids; D010936:Plant Extracts; D014665:Vasodilator Agents