Ganciclovir and standard high-dose immunoglobulins for the treatment of cytomegalovirus interstitial pneumonia in a bone marrow recipient.
A 47-year-old woman received an allogeneic bone marrow infusion because of chronic myeloid leukemia. Two months after the transplant she developed an interstitial pneumonia: bronchoalveolar lavage yielded cytomegalic cells with intranuclear bodies, and cytomegalovirus DNA was detected by in situ hybridization techniques. Ganciclovir and standard high-dose immunoglobulins were administered to the patient with resolution of the pneumonia. No relapse of pneumonia was observed after a 4-month follow-up. It seems that the favorable outcome of the potentially fatal pneumonia observed in this patient might be related to early diagnosis, and prompt administration of ganciclovir and standard high-dose immunoglobulins.
Iori
A P
AP
Dipartimento di Biopatologia Umana, Università La Sapienza, Roma, Italy.
Gentile
G
G
Petasecca Donati
P
P
Arcese
W
W
Martino
P
P
Mandelli
F
F
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007116:Immunization, Passive; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*
D015774:Ganciclovir