Eukaryotic DNA helicases.
DNA is very stable in its double-stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single-stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside-5'-triphosphate hydrolysis. This minireview focuses on the current knowledge of DNA helicases from eukaryotic cells.
Thömmes
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P
Department of Pharmacology and Biochemistry, University Zürich Irchel, Switzerland.
Hübscher
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U
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication; D014780:Viruses / Q000201:enzymology
D004247:DNA; D004265:DNA Helicases