Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.
Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.
Salvi
F
F
Institute of Neurology, University of Bologna, Italy.
Montagna
P
P
Plasmati
R
R
Rubboli
G
G
Cirignotta
F
F
Veilleux
M
M
Lugaresi
E
E
Tassinari
C A
CA
D000368:Aged; D000682:Amyloid / Q000235:genetics*; D000686:Amyloidosis / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000235:genetics*; D010292:Paresthesia / Q000235:genetics; D010375:Pedigree; D010523:Peripheral Nervous System Diseases / Q000235:genetics*; D011228:Prealbumin / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D013577:Syndrome
D000682:Amyloid; D005819:Genetic Markers; D011228:Prealbumin; C041120:amyloid prealbumin