[Insulin-like growth factors (IGF I and IGF II) and diabetes].
IGF I and IGF II are insulin-like peptide hormones circulating in blood bound to specific carrier proteins. IGF I mediates many actions of growth hormone--hence its designation as somatomedin C--and it stimulates cell replication, cell differentiation and the synthesis of cellular products (matrix proteins, etc.). Recent investigations in normal human subjects show that pharmacological doses of IGF I increase renal function and have profound metabolic effects that might prove to be useful in the treatment of conditions characterized by relative insulin resistance, such as type 2 diabetes, obesity and hyperlipidemia.
Froesch
E R
ER
Stoffwechselabteilung Medizinische Klinik, Universitätsspital Zürich.
Guler
H P
HP
Schmid
C
C
Zapf
J
J
D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007335:Insulin-Like Growth Factor II / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000502:physiology*
D007328:Insulin; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
Insulinähnliche Wachstumsfaktoren (IGF I und IGF II) und Diabetes.