Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats.
Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S2 receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin.
Dakshinamurti
K
K
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Sharma
S K
SK
Bonke
D
D
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D011736:Pyridoxine / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects; D014803:Vitamin B Complex / Q000494:pharmacology*
D011985:Receptors, Serotonin; D014803:Vitamin B Complex; D012701:Serotonin; D011736:Pyridoxine