Synthesis of 11C-labeled (+-)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imin e [(+-)-[11C]MK801].
The synthesis of C5 labeled (+-)-5-[11C]methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten- 5,10-imine [(+-)-[11C]MK801] has been accomplished via alkylation of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine-N-t- butylformamidine [(+-)-5-des-methyl MK801 formamidine). The 11C labeling is accomplished by reaction of the anion of (+-)-5-des-methyl MK801 formamidine, generated with s-butyllithium, and [11C]methyl iodide.
Kiesewetter
D O
DO
Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Finn
R D
RD
Rice
K C
KC
Monn
J A
JA
D002250:Carbon Radioisotopes; D003986:Dibenzocycloheptenes / Q000138:chemical synthesis*; D016291:Dizocilpine Maleate; D007553:Isotope Labeling / Q000379:methods*
D002250:Carbon Radioisotopes; D003986:Dibenzocycloheptenes; D016291:Dizocilpine Maleate