title: Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats.
abstract: The presence of activities that hydrolyse externally added ATP to adenosine in synaptosomal preparations from various sources is well demonstrated. The hydrolysis of ATP to AMP can be mediated either by the concerted action of enzymes or by an ATP-diphosphohydrolase (EC 3.6.1.5; apyrase). Undernutrition during the preweaning period can delay the development of several enzymes involved in the metabolism of neurotransmitters or neuronal function. In young rats, the presence of an apyrase in synaptosomal preparations from cerebral cortex was investigated. The results suggested that the hydrolysis of externally added ATP and ADP can be mediated by a single enzyme. The effects of preweaning undernutrition on the hydrolysis of ATP and ADP were also investigated. In weanling rats, previous undernutrition caused a decrease of about 20% in the hydrolysis of both substrates in synaptosomal fractions.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: J B
authors.initials: JB
authors.lastname: Rocha
authors.forename: C F
authors.initials: CF
authors.lastname: Mello
authors.forename: J J
authors.initials: JJ
authors.lastname: Sarkis
authors.forename: R D
authors.initials: RD
authors.lastname: Dias
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001081:Apyrase / Q000378:metabolism*; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D006868:Hydrolysis; D009748:Nutrition Disorders / Q000201:enzymology*; D009929:Organ Size; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000201:enzymology*; D014886:Weaning
chemical_list: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010744:Phosphoric Monoester Hydrolases; D001081:Apyrase; D000252:Calcium-Transporting ATPases