Valproyl CoA: an active metabolite of valproate?
Valproic acid exhibits a time course of antiepileptic effects suggesting a major role for active metabolites. It is proposed that valproyl-CoA, a valproate metabolite previously identified in liver, may accumulate in brain as a result of normal fatty acid turnover processes. Valproyl CoA could contribute to valproate's antiepileptic activity by stimulating Na+, K+-ATPase activity when brain ATP concentration is low.
Friel
P
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Epilepsy Center, Harborview Medical Center, Seattle, WA 98104.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014635:Valproic Acid / Q000097:blood / Q000378:metabolism*
D000214:Acyl Coenzyme A; D000927:Anticonvulsants; C045335:valproyl-coenzyme A; D014635:Valproic Acid; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase