Localization of 3H-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus.
Using 3H-prazosin, we have examined the distribution of alpha 1-adrenergic receptors in the supraoptic and paraventricular nuclei of the human hypothalamus. Our studies show that binding sites for 3H-prazosin in human hypothalamus possess pharmacological characteristics similar to those of rat brain. Autoradiographic studies revealed discrete localization of 3H-prazosin to the paraventricular and supraoptic nuclei.
Wilcox
B J
BJ
Division of Endocrinology and Metabolism, Veterans Administration Medical Center, Seattle, Wash.
Raskind
M A
MA
Ko
G N
GN
Baskin
D G
DG
Pascualy
M
M
Dorsa
D M
DM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D001667:Binding, Competitive; D006801:Humans; D008297:Male; D008875:Middle Aged; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis*; D011224:Prazosin; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D013495:Supraoptic Nucleus / Q000032:analysis*
D011942:Receptors, Adrenergic, alpha; D011224:Prazosin