title: [The effect of the selective blocking of synaptic transmission in the parafascicular complex on the neuronal activity of the sensorimotor cortex].
abstract: Peculiarities of spike responses of the sensorimotor cortex neurons and conditional activity induced by blockade of noradrenergic and serotoninergic inputs of the PF complex (CM-PF) have been studied in chronic experiments on cats with a preliminarily conditioned placing reaction to an auditory stimulus--a click. It is shown that an increase in the background activity of neurons of the sensorimotor cortex was caused by microinjections of obsidan, an adrenergic blocker, while depression--by microinjections of lysergoamid, a serotonin blocker. The effect of both blockers on the neuronal reactions evoked by conditional auditory stimulus was the same (depression). Both conditional placing and unconditional one were removed by partial blockade of monoaminergic inputs for 30-60 min. A conclusion is made that the character of the influence of the monoaminergic system on the sensorimotor cortex is determined not only by direct, but also by indirect influences due to neurons of the CM-PF complex of thalamic nuclei.
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Kruchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Sachenko
mesh_terms: D000161:Acoustic Stimulation; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage; D008839:Microelectrodes; D008845:Microinjections; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011433:Propranolol / Q000008:administration & dosage; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology
chemical_list: D008238:Lysergic Acid Diethylamide; D011433:Propranolol
vernacular_title: Vliianie izbiratel'nogo blokirovaniia sinapticheskoĭ peredachi v parafastsikuliarnom komplekse na aktivnost' neĭronov sensomotornoĭ kory.