[The positive chronotropic effects of salsolinol on the isolated rat heart].
Salsolinol (6,7-dioxy-1-methyl-1,2,3,4-tetrahydroisochinoline), a product of nonenzymatic condensation of dopamine and acetaldehyde, produced a dose-dependent positive chronotropic effect on the rat isolated perfused heart: EC = 5.6 X 10(-6) M. Inderal, a beta-adrenoreceptor antagonist (10(-5) g/ml), blocked and naloxone, an opioid receptor antagonist (3.1 X 10(-5) M), potentiated this effect. Apart from tachycardia, salsolinol induced arrhythmias which were inhibited by naloxone. Salsolinol seems to play an important role in regulating the heart performance.
Sokolova
N A
NA
Chudakov
L I
LI
Ashmarin
I P
IP
Vinogradova
T M
TM
Volodin
N D
ND
Vlasov
G P
GP
Nikonova
I N
IN
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D007546:Isoquinolines; D009270:Naloxone; C036617:salsolinol; D011433:Propranolol
Polozhitel'nye khronotropnye vliianiia sal'solinola na izolirovannom serdtse krysy.