In vitro effect of YTR (tazobactam) on plasmid and chromosomally mediated beta-lactamases.
The effect of tazobactam on the piperacillin susceptibility and on the beta-lactamase activity of different strains and species was evaluated. A synergistic effect was observed on the piperacillin susceptibility for all microorganisms tested, irrespective of the type and/or amount of beta-lactamase produced. Addition of gentamicin resulted in a further reduction of the piperacillin MIC. The enzyme activity after induction with piperacillin alone or in combination with tazobactam (4 mg/l) was quite similar.
Stobberingh
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Department of Medical Microbiology, State University of Limburg, Maastricht, The Netherlands.
D002875:Chromosomes / Q000378:metabolism; D002954:Citrobacter / Q000201:enzymology; D004357:Drug Synergism; D004754:Enterobacter / Q000201:enzymology; D004790:Enzyme Induction; D006801:Humans; D010397:Penicillanic Acid / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics; D011549:Pseudomonas / Q000201:enzymology; D012706:Serratia marcescens / Q000201:enzymology; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000032:analysis / Q000096:biosynthesis*
D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D001618:beta-Lactamases; D000078142:Tazobactam; D010878:Piperacillin