Effect of long-term treatment with massive doses of 1 alpha-hydroxyvitamin D3 on calcium-phosphate balance in patients with vitamin D-dependent rickets type II.
Three patients with vitamin D-dependent rickets type II were given massive doses of 1 alpha-hydroxyvitamin D3 for 29 to 36 months and their calcium-phosphate balance was studied during treatment and one month after cessation of treatment. During treatment fasting hypercalciuria was observed in patient 1 and an increased rate of calcium excretion after calcium loading in patients 1 and 2. In these patients, calcium excretion was parallel with the serum 24,25-dihydroxyvitamin D concentration, which may reflect the level of receptor for 1,25-dihydroxyvitamin D. These findings suggested that the responsiveness to 1,25-dihydroxyvitamin D improved during long-term treatment of these two patients with vitamin D-dependent rickets type II.
Takeda
E
E
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
Yokota
I
I
Saijo
T
T
Kawakami
I
I
Ito
M
M
Kuroda
Y
Y
D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007015:Hypophosphatemia, Familial / Q000188:drug therapy* / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D013997:Time Factors
D006887:Hydroxycholecalciferols; D010710:Phosphates; D002118:Calcium; C008088:alfacalcidol