[Cerebrovascular disorders associated with livedo (Sneddon's syndrome): its relation to lupus anticoagulant].
The clinical manifestations of Sneddon's syndrome (cerebrovascular disorder, livedo reticularis, peripheral venous thrombosis++, cardiac pathology, obstetric pathology--fetal loss and intrauterine fetal death) are characteristic of the antiphospholipid syndrome. A lupus anticoagulant (LA), one of the types of antiphospholipid antibodies, was detected in the blood plasma of 18 out of 30 patients with Sneddon's syndrome. The negative results of LA-examination in 12 patients don't exclude the presence of other antiphospholipid antibodies. So 16 of 30 patients had anticardiolipin antibodies, among them being 6 LA-negative patients. The authors discuss the significance of antiphospholipid antibodies in the genesis of vascular abnormalities in patients with Sneddon's syndrome.
Kalashnikova
L A
LA
Prudnikova
L Z
LZ
Nasonov
E P
EP
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001779:Blood Coagulation Factors / Q000276:immunology*; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000276:immunology; D003490:Cyanosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008875:Middle Aged; D010743:Phospholipids / Q000276:immunology*; D012871:Skin Diseases / Q000209:etiology* / Q000276:immunology; D013577:Syndrome
D001323:Autoantibodies; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids
Sosudistoe porazhenie mozga, sochetaiushcheesia s livedo (sindrom Sneddona): sviaz' s volchanochnym antikoaguliantom.