Some properties of sodium channels in neuroblastoma cells modified with scorpion toxin and chloramine-T. Single channel measurements.
Currents through sodium channels of neuroblastoma cells were measured using patch technique in outside-out configuration. Scorpion toxin (ScTX) produced 3 to 4 fold prolongation of mean open time and increased number of reopenings. The mean open times showed slow fluctuations around some average values. The distribution of channel open times for ScTX-modified channels required more than one exponential to be fitted. Chloramine-T (ChT) produced qualitatively similar, though weaker, prolongation of open times.
Mozhayeva
G N
GN
Institute of Cytology, Academy of Sciences of the USSR, Leningrad.
Naumov
A P
AP
Kuryshev YuA
Nosyreva
E D
ED
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D002460:Cell Line; D002700:Chloramines / Q000494:pharmacology*; D004553:Electric Conductivity; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009447:Neuroblastoma; D011336:Probability; D012604:Scorpion Venoms / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D014105:Tosyl Compounds; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000502:physiology*
D000891:Anti-Infective Agents, Local; D002700:Chloramines; D012604:Scorpion Venoms; D015222:Sodium Channels; D014105:Tosyl Compounds; C016300:chloramine-T