title: [Modifying regeneration success of glued nerve anastomosis by local corticoid administration].
abstract: Although the fibrin adhesion is being used in many areas of surgery with increasing success, it has, however, not become fully established in nerve anastomosis. At the beginning fibrin clots dissolved prematurely and dehiscences ensued. Antifibrinolytic substances had to be added to the adhesive to stabilize the clot. As a result fibroses occurred frequently, which up to now encumber nerve adhesive. The conventional suture technique is still not convincing also. Because reports showed a beneficial influence on conventional nerve sutures, the object of this study was a comparison between conventional suture technique and nerve anastomosis by fibrin adhesives with and without additive of corticosteroids. Electrophysiological methods were used, because regeneration is clinically determinating. The results do not recommend the use of local corticosteroids in nerve anastomoses fixed by fibrin adhesive.
authors.affiliation: Neurochirurgische Klinik Westfälischen Wilhelms-Universität Münster.
authors.forename: T
authors.initials: T
authors.lastname: Herter
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000601:surgery*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery; D009435:Synaptic Transmission / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D015718:Fibrin Tissue Adhesive; C009935:prednisolone acetate; D011239:Prednisolone
vernacular_title: Die Beeinflussung des Regenerationserfolges einer geklebten Nervenanastomose durch lokale Corticoidapplikation.