High urinary cAMP in hypertensives despite careful drug treatment--an epidemiological study from the Dalby population.
The correlation between serum calcium (S-Ca), plasma parathyroid hormone (P-PTH) and hypertension was determined in a population-based, cross-sectional study of carefully treated hypertensives (n = 391; diastolic blood pressure 90.2 mmHg; 57 years) compared with normotensive controls (n = 328; diastolic blood pressure 82.1 mmHg; 57 years). Levels of urinary cyclic-adenosinemonophosphate (U-cAMP), but not of plasma cAMP (P-cAMP), were higher (P less than 0.001) in hypertensives than in controls. This was the case regardless of the type of drug treatment and the blood pressure level that was reached. U-cAMP correlated with adrenaline in multivariate analyses. S-Ca levels were higher (P less than 0.001) and S-Mg levels were lower (P less than 0.001) in hypertensives than in controls. This was not explained by thiazide treatment. Thus, despite 'adequate' blood pressure reduction, substantial differences in S-Ca, S-Mg and U-cAMP still exist between hypertensives and normotensive controls.
Nilsson
P
P
Health Sciences Centre, Lund University, Dalby, Sweden.
Lindholm
L
L
Winther
K
K
Scherstén
B
B
Hesch
R D
RD
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood*; D003430:Cross-Sectional Studies; D000242:Cyclic AMP / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood*; D013548:Sweden / Q000453:epidemiology
D000959:Antihypertensive Agents; D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002118:Calcium