title: Detection of inflammatory lesions with radiolabelled immunoglobulins.
abstract: Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Blok
authors.forename: M
authors.initials: M
authors.lastname: von Ogtrop
authors.forename: J W
authors.initials: JW
authors.lastname: Arndt
authors.forename: J A
authors.initials: JA
authors.lastname: Camps
authors.forename: R I
authors.initials: RI
authors.lastname: Feitsma
authors.forename: W
authors.initials: W
authors.lastname: Goedemans
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D000818:Animals; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005490:Focal Infection / Q000000981:diagnostic imaging*; D005710:Gallium Radioisotopes; D006614:Hindlimb; D007136:Immunoglobulins; D051379:Mice; D010865:Pilot Projects; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D007136:Immunoglobulins; D013668:Technetium Tc 99m Aggregated Albumin; D019343:Citric Acid; D013670:Sodium Pertechnetate Tc 99m