[Arachidonic acid metabolites on peripheral blood plasma in patients with bronchial asthma].
To assess the role of arachidonic acid metabolites in pathogenesis of bronchial asthma, we measured thromboxane B2 (TxB2), 6-keto PGF1 alpha, leukotriene (LT) C4, and LTB4 in venous blood plasma in patients with bronchial asthma and in controls. The level of TxB2 was significantly higher in 18 asthmatics with attacks than that in 11 controls (77.3 +/- 48.8 pg/ml vs 48.8 +/- 9.4 pgml). The levels of 6-keto PGF1 alpha in both asthmatics with attacks (17.8 +/- 6.7 pg/ml) and without an attack (16.4 +/- 9.7) were significantly higher than that in controls (11.6 +/- 3.9 pg/ml). The levels of LTC4 in asthmatics with attacks (0.84 +/- 0.11 ng/ml, n = 11) were significantly higher than that in controls, furthermore the level of LTC4 in asthmatics without an attack. The level of LTB4 was significantly higher in asthmatics with attacks (295.0 +/- 160.7 pg/ml, n = 26) than that in controls (161.7 +/- 25.3 pg/ml, n = 12) and asthmatics without an attack (182.4 +/- 97.9 pg/ml, n = 22). These findings suggest that the arachidonic acid metabolites are related to the asthma attack and are associated with the pathogenesis of bronchial asthma.
Fujimoto
K
K
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Yoshikawa
S
S
Shinozaki
S
S
Matsuzawa
Y
Y
Kubo
K
K
Kobayashi
T
T
Sekiguchi
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001249:Asthma / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013189:SRS-A / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood*
D001095:Arachidonic Acids; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha