[Preparation of toxoid from Taiwan cobra (Naja naja atra) venom].
Potency of sixty antitoxic unit was reached after two immunizations in 2-week intervals of rabbits and horses with 10-25 mg Taiwan cobra (Naja naja atra) venom which was detoxified by 0.125% glutaraldehyde. Now this procedure has become a routine antivenine-producing method by which snake bivalent neurotropic antivenine is produced. The stability test showed that Taiwan cobra toxoid kept at 37 degrees C for 40 days, the antigenicity increased by 24% and toxicity decreased by 10% as compared to the toxoid maintained at 4 degrees C.
Miao
B L
BL
National Institute of Preventive Medicine, Department of Health, Taipei, R.O.C.
Liau
M Y
MY
Huang
R J
RJ
Chen
S W
SW
Chen
T K
TK
Chang
S C
SC
D000818:Animals; D000997:Antivenins / Q000096:biosynthesis; D004546:Elapid Venoms / Q000032:analysis*; D005260:Female; D006736:Horses; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011817:Rabbits; D013624:Taiwan; D014121:Toxoids / Q000032:analysis*
D000997:Antivenins; D004546:Elapid Venoms; D014121:Toxoids