Long-term verapamil treatment increases [3H]imipramine binding in human platelets.
The effect of long-term verapamil treatment on [3H]imipramine binding to the serotonin transporter in human platelets was studied. A significant increase (24%, P less than 0.05) in the density of high-affinity imipramine binding sites was observed in platelets of cardiac patients maintained exclusively on verapamil. The up-regulation of the serotonin transporter may be relevant to the previously reported beneficial effect of verapamil in affective disorders.
Cohen
A
A
Pediatric Department, Asaf Harofeh Medical Center, Tel-Aviv, Israel.
Weizman
A
A
Eldar
M
M
Rehavi
M
M
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007099:Imipramine / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D012701:Serotonin / Q000097:blood; D015854:Up-Regulation / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D012701:Serotonin; D014700:Verapamil; D007099:Imipramine