Detection of respiratory chain dysfunction by measuring lactate and pyruvate production in cultured fibroblasts.
Wijburg
F A
FA
Department of Pediatrics, University Hospital of Amsterdam (AMC), The Netherlands.
Feller
N
N
Ruitenbeek
W
W
Trijbels
J M
JM
Sengers
R C
RC
Scholte
H R
HR
Przyrembel
H
H
Wanders
R J
RJ
D000592:Amino Acid Metabolism, Inborn Errors / Q000175:diagnosis*; D002478:Cells, Cultured; D002675:Child, Preschool; D030401:Cytochrome-c Oxidase Deficiency; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D008928:Mitochondria / Q000201:enzymology*; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid; D011808:Quinone Reductases / Q000172:deficiency
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; C041831:NADH dehydrogenase (quinone); D011808:Quinone Reductases