Maternal age does not affect tetrahydrocannabinol's in utero actions in rats.
The potential contribution of maternal age to tetrahydrocannabinol's (THC) in utero effects in rats was studied. Pregnant animals were intubated with 25, 10 or 0 mg/kg of THC from gestation day six to parturition. Animals in the 10 and 0 mg/kg groups were pair fed to those given the 25 mg/kg dose. Each series of doses was administered to females three, four or six months of age. THC lowered maternal weight gain and weights of offspring at birth and at 21 days of age, but did not affect litter size, spontaneous alternation or passive avoidance learning in offspring. Increased maternal age was associated with smaller litter size and lower birth weight and weight at 21 days, but did not interact significantly with THC.
Abel
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Fetal Alcohol Research Center, Wayne State University, Detroit, Michigan.
Subramanian
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Zajac
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001724:Birth Weight / Q000187:drug effects; D013759:Dronabinol / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D012727:Sex Characteristics; D015430:Weight Gain / Q000187:drug effects
D013759:Dronabinol