title: Long insertions within telomeres contribute to chromosome size polymorphism in Plasmodium berghei.
abstract: During prolonged in vivo mitotic multiplication of a Plasmodium berghei ANKA clone (8417HP), parasites that contained an enlarged version of chromosome 4 were observed. Restriction mapping and hybridization results demonstrated that the extra DNA present in the enlarged chromosome consists of 2.3-kb tandem repeats, known to be normally located in subtelomeric position at several chromosomal ends but absent in the original chromosome. The inserted 2.3-kb units appeared to interrupt one of the original telomeres and to create an internal (approximately 1-kb-long) telomeric sequence.
authors.affiliation: Laboratory of Cellular Biology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Pace
authors.forename: M
authors.initials: M
authors.lastname: Ponzi
authors.forename: E
authors.initials: E
authors.lastname: Dore
authors.forename: C
authors.initials: C
authors.lastname: Janse
authors.forename: B
authors.initials: B
authors.lastname: Mons
authors.forename: C
authors.initials: C
authors.lastname: Frontali
mesh_terms: D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010962:Plasmodium berghei / Q000235:genetics*; D011110:Polymorphism, Genetic; D015183:Restriction Mapping
chemical_list: D004251:DNA Transposable Elements; D015345:Oligonucleotide Probes