Persistent metronidazole-induced peripheral neuropathy.
We report the case of a young woman with Crohn's disease who developed a debilitating peripheral neuropathy when treated with metronidazole 2000 mg/d for 50 days. The patient's neuropathy improved considerably after the discontinuation of metronidazole, but still persists two years later. The current literature on this topic is reviewed. Reports such as this one underscore the need to closely monitor the neurologic status of patients undergoing chronic treatment with metronidazole.
Boyce
E G
EG
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, PA 19104.
Cookson
E T
ET
Bond
W S
WS
D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D008795:Metronidazole