[Changes of adrenoceptor density in heart and brain and the reactivity of isolated pulmonary artery ring in atherosclerotic rabbit].
The alpha-adrenoceptor density in cerebral cortex and brain stem as well as the beta-adrenoceptor density in heart were measured by radioligand binding assay in normal rabbits (group 1), atherosclerotic rabbits (group 2) and atherosclerotic rabbits treated orally with aspirin 20 mg/kg daily for 16 wk (group 3). The results showed that the beta-receptor density and the KD values of the hearts among the 3 groups and the alpha-receptor density and KD of brain stem between groups 1 and 2 were not significantly different except that the alpha-receptor density in group 3 was decreased slightly. The number of alpha 1-receptor of cerebral cortex was decreased more in group 2 than that in group 3. The contractile responses of isolated pulmonary artery ring by NE were similar among the 3 groups but the reactivity to 5-HT in group 3 was increased significantly.
Zeng
G Y
GY
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Sun
Y D
YD
Tian
B H
BH
Wang
Z
Z
Hu
Y H
YH
An
Y
Y
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular; D009206:Myocardium / Q000378:metabolism*; D011651:Pulmonary Artery / Q000378:metabolism; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D001241:Aspirin