Inhibition by tetrandrine of calcium currents at mouse motor nerve endings.
The inhibition by the bis-benzyl-isoquinoline alkaloid tetrandrine of motor terminal calcium currents has been studied using extracellular, perineuronal electrodes in the M. triangularis preparation of the mouse. The calcium plateau current was irreversibly blocked, whereas the fast calcium current remained unaffected. From these results a calcium antagonism on neuronal calcium channels involved in transmitter release at motor nerve terminals is suggested.
Wiegand
H
H
Heinrich-Heine-University Düsseldorf, Department of Neurotoxicology, F.R.G.
Meis
S
S
Gotzsch
U
U
D015761:4-Aminopyridine / Q000031:analogs & derivatives / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology*; D000077770:Amifampridine; D000818:Animals; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D051379:Mice; D009046:Motor Neurons / Q000502:physiology*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D015221:Potassium Channels; D013757:Tetraethylammonium Compounds; C009438:tetrandrine; D019789:Tetraethylammonium; D015761:4-Aminopyridine; D000077770:Amifampridine