Schistosoma haematobium: the effect of Astiban on the cell composition and ultrastructure of the vitelline gland and the ultrastructure of the tegument and gastrodermis.
Treatment of Schistosoma haematobium (Nigerian strain) in hamsters with a single dose of 40 mg/kg of Astiban caused a reduction in the number of S1, S2, and S3 vitelline cells and an increase in S4 cells. Following seven daily doses of the drug, a marked reduction in S1 cells and a complete loss of S2 and S3 cells occurred such that 95% of the cells were S4 cells, all of which were structurally abnormal. Coagulation and disintegration of the protein granules of the vitelline droplets occurred with increase in lipid droplets, swelling of the nuclear membrane and an increase in cytosegresomes. Blebbing of the tegument in both sexes occurred following a single treatment and vacuolation of the basal infolds and alterations to the mitochondria also resulted, but severe erosion of the tegument was rare even following repeated drug treatment. Damage to the gastrodermis was severe with the development of autophagic vacuoles containing whorls of myelin and sequestered portions of damaged tissue. The degree of damage increased with the number of drug treatments.
Leitch
B
B
School of Biological Sciences, University College, Bangor, Gwynedd, UK.
Probert
A J
AJ
D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D012548:Schistosoma haematobium / Q000187:drug effects* / Q000648:ultrastructure; D012553:Schistosomiasis haematobia / Q000188:drug therapy*; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use; D004113:Succimer / Q000494:pharmacology* / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D009942:Organometallic Compounds; D012556:Schistosomicides; D013438:Sulfhydryl Compounds; C004443:stibocaptate; D004113:Succimer