[The Na, K-ATPase activity of the separate structural components of the guinea-pig visual system in hypoxia].
Different degree of sensitivity to acute hypoxia in vivo has been shown in guinea-pig pigmented epithelium, retina and visual cortex Na, K-ATPase. The highest degree of the enzyme activity inhibition has been noted in the pigmented epithelium (more than 3 times), lower inhibition-in visual cortex (26%) and the lowest-in the retina (18%). In contrast to Na, K-ATPase, hypoxia effect on Mg-ATPase resulted in both inhibition and activation of the enzyme in all 3 structures. Reoxygenation following acute hypoxia increases Na, K-ATPase activity inhibition in the retina and visual cortex. But under reoxygenation the enzyme activity is recovered in the pigmented epithelium. Preliminary administrations of vitamin E completely prevented Na, K-ATPase activity inhibition in all studied structures.
Magomedov
N M
NM
Azimova
A M
AM
Dzhafarov
A I
AI
D000208:Acute Disease; D000818:Animals; D001273:Atmosphere Exposure Chambers; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005123:Eye / Q000201:enzymology* / Q000503:physiopathology; D006168:Guinea Pigs; D000860:Hypoxia / Q000201:enzymology* / Q000503:physiopathology; D010857:Pigment Epithelium of Eye / Q000201:enzymology / Q000503:physiopathology; D012160:Retina / Q000201:enzymology / Q000503:physiopathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014793:Visual Cortex / Q000201:enzymology* / Q000503:physiopathology
D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase
Na, K-ATFaznaia aktivnost' otdel'nykh strukturnykh komponentov zritel'noĭ sistemy morskikh svinok pri gipoksii.