[The effect of morphine and naloxone on histamine- and serotonin-induced bronchospasms].
The effects of morphine and naloxone on bronchospasm induced by histamine and serotonin were studied on conscious rats. Morphine was found to increase histamine-induced bronchospasm and to prevent serotonin-induced bronchoconstriction. Naloxone prevented histamine-induced bronchospasm and exerted no effect on serotonin-induced bronchospasm.
Karpov
O I
OI
D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006632:Histamine; D009020:Morphine / Q000627:therapeutic use*; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012701:Serotonin
D011957:Receptors, Opioid; D012701:Serotonin; D009270:Naloxone; D009020:Morphine; D006632:Histamine
Vliianie morfina i naloksona na bronkhospazm, vyzvannyĭ gistaminom i serotoninom.