[The effect of the intracellular calcium concentration on GABA-activated ion currents in the neurons of the rat cerebellum].
Purkinje neurons from the rat cerebellum were investigated using a patch clamp technique. An increase in the concentration of intracellular calcium from 10(-8) to 10(-6) mol/l both considerably decreased the amplitude of the maximum GABA-activated chloride current and slightly reduced affinity of the GABA receptor.
Marchenko
S M
SM
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D015220:Calcium Channels; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D002118:Calcium
Vliianie vnutrikletochnoĭ kontsentratsii kal'tsiia na GAMK-aktiviruemye ionnye toki v neĭronakh mozzhechka krysy.