[A case of hepatocellular carcinoma treated by intrahepatic arterial administration of anticancer agents: serial determination of the concentration of the chemotherapeutic agents in serum and dialysate during hemodialysis].
The concentration of adriamycin (ADR) and mitomycin C (MMC) were measured in serum and dialysate in a patient with hepatocellular carcinoma complicating chronic renal failure. ADR at a dose of 20 mg and MMC at 10 mg were administered through the hepatic artery or peripheral vein during hemodialysis. ADR and MMC became undetectable after 24 hours and 2 hours, respectively. On the other hand, while MMC was detected in dialysate, but ADR was not. Consequently, it was speculated smaller molecular weight of MMC (334.34) than that of ADR (579.99) might be responsible for the appearance of MMC in dialysate. These results suggest that hemodialysis may be effective in reducing side effects of certain anticancer agents. Serum concentration of the anticancer agents injected through hepatic artery was similar to that injected intravenously.
Yoshida
T
T
First Dept. of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan.
Ohsawa
K
K
Goto
T
T
Chiba
S
S
Nakamura
Y
Y
Kondoh
K
K
Sasaki
S
S
Sekine
K
K
Katayama
S
S
Moriai
O
O
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000097:blood*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000097:blood*; D006435:Renal Dialysis
D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin