[Comparative use of analogs of prostaglandin by intravenous or vaginal administration in termination of pregnancy].
We made a prospective study using vaginal suppository of Géméprost (analogue of PGE1) and intravenous infusion of Sulprostone (analogue of PGE2) in thirty second- and third-trimesters pregnancy terminations. The efficacy was excellent for both procedures: only one failure, mean duration of abortion of 15 h 15 with Sulprostone, interval of 17 hours with Géméprost. In this case, the delay was shorter when vaginal administration was made every 6 hours. The evacuation of the uterus was very good, however one aspiration was made three days after abortion. Few side effects were observed with these two drugs: one case of fever, one case of vomiting, both with Sulprostone: two cases of nausea, one case of diarrhoea with Géméprost. We think that the effectiveness is marked and comparable, allowing the use of epidural anesthesia.
Poulain
P
P
Service de Gynécologie-Obstétrique, CHU Rennes, Hôpital Sud.
Blanchot
J
J
Roze
J M
JM
Babatasi
S
S
Grall
J Y
JY
D000019:Abortifacient Agents / Q000008:administration & dosage*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000282:Administration, Intravaginal; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007262:Infusions, Intravenous; D011247:Pregnancy; D011446:Prospective Studies
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; C021182:gemeprost; C016767:sulprostone; D000527:Alprostadil; D015232:Dinoprostone
Utilisation comparée des analogues de prostaglandines en perfusion ou par ovules vaginaux dans les interruptions de grossesses.