Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus.
Anti-neutrophil cytoplasm antibody (ANCA) has been shown to be no marker of systemic lupus erythematosus (SLE) including lupus nephritis or of progressive systemic sclerosis (PSS). Antibodies against myeloperoxidase (anti-MPO) and elastase, two granulocyte lysosomal enzymes, were found in patients with SLE but not in those with PSS, except for one patient who had anti-MPO. Anti-MPO was present in 21% of patients with SLE, and at low concentrations in about 80% of these cases. Anti-elastase was found in four patients with SLE. In another group of six patients with a SLE-like syndrome induced by anti-hypertensive treatment with the anti-hypertensive hydralazine, anti-MPO antibodies occurred in all six, and anti-elastase antibodies in five. Monitored during a 2-year follow-up period, anti-MPO antibodies were found to persist, whereas anti-elastase antibodies were rapidly eliminated, after withdrawal of the drug.
Nässberger
L
L
Department of Medical Microbiology, University of Lund, Sweden.
Sjöholm
A G
AG
Jonsson
H
H
Sturfelt
G
G
Akesson
A
A
D001323:Autoantibodies / Q000378:metabolism*; D001324:Autoantigens / Q000276:immunology; D003593:Cytoplasm / Q000201:enzymology / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010196:Pancreatic Elastase / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D006830:Hydralazine; D009195:Peroxidase; D010196:Pancreatic Elastase