title: Detection of human papillomavirus types 6/11, 16 and 18 in exfoliated cells from the uterine cervices of Japanese women with and without lesions.
abstract: Human papillomavirus (HPV) infection of the uterine cervices of Japanese women with and without lesions was identified by the filter in situ hybridization method. Exfoliated cervical cells from 23 cervical papillary condylomas, 70 cervical intraepithelial neoplasia (CIN) grade I/II, 26 CIN III, 31 invasive cervical cancers and 666 cervices without evidence of disease (including 53 pregnant women) were tested for the presence of HPV types 6/11, 16 and 18. The positive rates for the detection of HPV types 6/11, 16 and 18 DNA were 47.8%, 26.1% and 8.7% in cervical condylomas, 5.7%, 15.7% and 8.6% in CIN I/II, 0, 34.6% and 0 in CIN III, 3.2%, 38.7% and 9.7% in invasive cervical cancers and 0.9%, 1.8% and 0.6% in the control cervices. These data suggest that, in Japan, HPV6/11, HPV16 and HPV18 infections are also prevalent in cervical cells with normal phenotype, and the type of HPV infection of the uterine cervix is related to the histological diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Yokota
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Shiromizu
authors.forename: T
authors.initials: T
authors.lastname: Kawana
authors.forename: M
authors.initials: M
authors.lastname: Mizuno
mesh_terms: D002584:Cervix Uteri / Q000382:microbiology; D003218:Condylomata Acuminata / Q000382:microbiology; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D007564:Japan; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000453:epidemiology; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000382:microbiology
chemical_list: D015342:DNA Probes; D004279:DNA, Viral