Treatment of murine coccidioidal meningitis with SCH39304.
The triazole SCH39304 was compared with itraconazole and fluconazole for treatment of murine coccidioidal meningitis. Mice were treated for 30 days with 1, 5, 10, or 30 mg of each drug per kg of body weight. Survival and brain tissue counts were measured. At equivalent doses, SCH39304 was more effective than the other triazoles.
Defaveri
J
J
Department of Medicine and Research, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284.
Sun
S H
SH
Graybill
J R
JR
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D008581:Meningitis / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C056513:Sch 39304; D017964:Itraconazole; D015725:Fluconazole; D007654:Ketoconazole