Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.
Leib
D A
DA
Laboratory of Tumor Virus Genetics, Dana Farber Cancer Institute, Boston, Massachusetts.
Ruffner
K L
KL
Hildebrand
C
C
Schaffer
P A
PA
Wright
G E
GE
Coen
D M
DM
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D046508:Culture Techniques; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D018139:Simplexvirus / Q000201:enzymology*; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors*; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014775:Virus Activation / Q000187:drug effects*
D000998:Antiviral Agents; C056703:N(2)-phenyl-2'-deoxyguanosine; C065261:N(2)-(3-trifluoromethylphenyl)guanine; D006147:Guanine; D013937:Thymidine Kinase; D003849:Deoxyguanosine