[Unusual manifestation of scleroderma of the trunk].
We present the case of an 81-year-old women with progressive systemic scleroderma. In addition to the typical manifestations of diffuse (truncal) scleroderma, including involvement of the esophagus, lungs and muscles, there were two unusual findings: large, non-sclerosing areas on the trunk simulating the disabling type of circumscribed scleroderma and high titers of anticentromere antibodies, while there were no anti-Scl-70 antibodies. The disease responded to treatment with griseofulvin.
Hackel
H
H
Dermatologische Klinik, Julius-Maximilians-Universität Würzburg.
Zillikens
D
D
Lechner
W
W
Burg
G
G
D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D002503:Centromere / Q000276:immunology; D004264:DNA Topoisomerases, Type I; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D009687:Nuclear Proteins / Q000276:immunology; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
D000974:Antibodies, Antinuclear; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; D004264:DNA Topoisomerases, Type I
Ungewöhnliche Ausprägung einer Stammsklerodermie.