The biological activity of retinoids in melanoma cells. Induction of expression of retinoic acid receptor-beta by retinoic acid in S91 melanoma cells.
The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-didehydro-all trans-retinoic acid also induced expression of RAR-beta but were only effective at concentrations 100-fold greater than all trans-retinoic acid. The expression of RAR-alpha and RAR-gamma was unaffected by retinoic acid.
Redfern
C P
CP
Department of Dermatology, Medical School, University of Newcastle upon Tyne, UK.
Daly
A K
AK
Latham
J A
JA
Todd
C
C
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics*; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects*; D007700:Kinetics; D008546:Melanoma, Experimental; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D018168:Receptors, Retinoic Acid; D013237:Stereoisomerism; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology*
D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; C064742:3,4-didehydroretinoic acid; D014212:Tretinoin; D003513:Cycloheximide