title: Effects of cyproterone acetate and testosterone treatments on some physical parameters, angiotensin converting enzyme activity and fertilizing ability of spermatozoa of domestic cocks (Gallus domesticus).
abstract: Healthy adult cocks were administered through the intramuscular route with 1 or 15 mg cyproterone acetate (CyA)/kg b. wt. or testosterone at the rate of 1.5 mg/kg b. wt. daily for a period of 25 days. High doses of CyA and testosterone caused severe suppression (P less than 0.01) of semen volume, sperm concentration, sperm motility and angiotensin converting enzyme activity (ACE EC 3.4.15.1). Fertilizing ability of spermatozoa was also reduced drastically at the end of treatment period. No loss of sexual behaviour was observed in treated birds as compared to controls. Recovery in all parameters from deleterious effects of these drugs was rapid after cessation of treatment. Lower doses of CyA did not affect the parameters of semen. The results are discussed in relation to the possible mechanism of action of CyA and testosterone.
authors.affiliation: Division of Physiology and Reproduction, Central Avian Research Institute, Izatnagar, India.
authors.forename: J
authors.initials: J
authors.lastname: Mohan
authors.forename: R P
authors.initials: RP
authors.lastname: Moudgal
authors.forename: N B
authors.initials: NB
authors.lastname: Singh
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology*; D017373:Cyproterone Acetate; D005298:Fertility / Q000187:drug effects; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D013094:Spermatozoa / Q000187:drug effects* / Q000201:enzymology; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D017373:Cyproterone Acetate; D003534:Cyproterone; D007703:Peptidyl-Dipeptidase A