title: Vinylogous and coupled hexahydroquinolinones and dihydropyridines with calcium-modulating effects.
abstract: The vinylogous, anellated and non-anellated dihydropyridines 4 and their coupled analogues 5 are accessible through Hantzsch-type cyclization reactions. IR, 1H-NMR, and mass spectral data are in agreement with the postulated structures. Pharmacological investigations on electrically-stimulated left atria of guinea pigs with some of the compounds gave rise to positive inotropic activities whereas BaCl2-induced contractions of the ileum were inhibited in a dose-dependent manner by some of the products.
authors.affiliation: Institute for Pharmacy, Johannes Gutenberg University of Mainz, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Rose
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D015363:Quinolones