Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder.
Cholecystokinin-tetrapeptide (CCK-4) and placebo were injected to 11 panic disorder patients. CCK-4 induced a panic attack identical to spontaneous panic attacks in all patients; placebo did not induce any attacks. The role of CCK-4 in anxiety disorders is discussed.
Bradwejn
J
J
McGill University, Montreal, Quebec.
Koszycki
D
D
Meterissian
G
G
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D005755:Gastrins; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*; D013758:Tetragastrin
D005755:Gastrins; D013758:Tetragastrin