The effects of haloperidol on thought disorder and IQ in schizophrenia.
The impact of haloperidol treatment on the Wechsler Adult Intelligence Scale (WAIS) and the Thought Disorder Index was investigated in a group of 19 patients with schizophrenia tested both before and after 26 days of treatment with haloperidol. Thought disorder scores declined significantly over the course of treatment and fewer patients demonstrated severe forms of thought disorder at the end of the trial. WAIS performance improved significantly but the magnitude of change was consistent with the literature on expected practice effects. Thought disorder scores were negatively correlated with IQ at baseline, but not at Day 26. The results suggest a partial dissociation of thought disorder and other cognitive functions in schizophrenia.
Gold
J M
JM
New York Hospital, Cornell Medical Center, Westchester Division.
Hurt
S W
SW
D000328:Adult; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008137:Longitudinal Studies; D008297:Male; D011594:Psychometrics; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013850:Thinking / Q000187:drug effects*; D014888:Wechsler Scales
D006220:Haloperidol