The clinical significance of platelet membrane glycoproteins.
To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge of how these receptors function. Elucidation of the role of platelet glycoproteins in normal hemostasis has also provided insight into possible strategies for modulating receptor function in thrombotic disorders and for identifying activated platelets as markers of thrombus formation.
McEver
R P
RP
St. Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City.
D000911:Antibodies, Monoclonal; D001791:Blood Platelet Disorders / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D015539:Platelet Activation / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010980:Platelet Membrane Glycoproteins / Q000172:deficiency / Q000276:immunology / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000172:deficiency / Q000502:physiology*
D000911:Antibodies, Monoclonal; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface