title: Multiple sequence elements in the U3 region of the leukemogenic murine retrovirus SL3-2 contribute to cell-dependent gene expression.
abstract: Determination of the U3 sequence of the leukemogenic murine retrovirus SL3-2 revealed close relationships to SL3-3, Akv, and Gross passage A viruses. The SL3-2 and Akv regions showed wide differences in their relative transcriptional activity in four cell lines as determined by U3-driven transient expression assays. The U3 regions of SL3-2 and SL3-3 gave rise to similar but not identical levels of expression. Deletion mapping of the SL3-2 U3 region points to several determinants of expression of different relative importance in the cell lines tested.
authors.affiliation: Department of Molecular Biology and Plant Physiology, University of Aarhus, Denmark.
authors.forename: H Y
authors.initials: HY
authors.lastname: Dai
authors.forename: M
authors.initials: M
authors.lastname: Etzerodt
authors.forename: A J
authors.initials: AJ
authors.lastname: Baekgaard
authors.forename: S
authors.initials: S
authors.lastname: Lovmand
authors.forename: P
authors.initials: P
authors.lastname: Jørgensen
authors.forename: N O
authors.initials: NO
authors.lastname: Kjeldgaard
authors.forename: F S
authors.initials: FS
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D005822:Genetic Vectors; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004279:DNA, Viral