Anti-neuronal antibodies in paraneoplastic neurological disorders with small-cell lung carcinoma.
Auto-antibodies of the neuronal anti-nuclear antibody (anti-Hu) type were found in serum of three patients suspected of a paraneoplastic syndrome of the central nervous system. In all three a small cell carcinoma of the lung was detected. The sera showed bright staining of neuronal nuclei sparing the nucleolus. In two patients the antibody was of the IgG class (titers 1:1600 and 1:4000). In one patient only an IgM class antibody was present (titer 1:1000). The presence of the anti-Hu antibody strongly supports a diagnosis of a paraneoplastic neurological syndrome associated with small cell carcinoma of the lung.
Moll
J W
JW
Department of Neurology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Henzen-Logmans
S C
SC
Vecht
C J
CJ
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000276:immunology*; D009423:Nervous System Neoplasms / Q000276:immunology*; D009474:Neurons / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M