title: Carnosine as a potential scavenger of oxidants generated by stimulated neutrophils.
abstract: Luminol-dependent chemiluminescence of PMA-stimulated human neutrophils decrease more than by 50% in the presence of physiological concentrations of carnosine (20 mM). This inhibition is the result of carnosine ability to scavenge hypochlorite (OCl-), since carnosine exerts a similar effect on chemiluminescence produced by myeloperoxidase-H2O2-Cl- and OCl(-)-H2O2 systems. The previously undocumented property of this dipeptide to scavenge active oxygen species requires further experiments.
authors.affiliation: All Union Research Institute of Highly Pure Biopreparations, Leningrad, USSR.
authors.forename: B P
authors.initials: BP
authors.lastname: Sharonov
authors.lastname: Govorova NJu
authors.forename: S N
authors.initials: SN
authors.lastname: Lyzlova
mesh_terms: D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D006997:Hypochlorous Acid / Q000097:blood; D007700:Kinetics; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D009195:Peroxidase / Q000097:blood
chemical_list: D004151:Dipeptides; D005609:Free Radicals; D006997:Hypochlorous Acid; D002336:Carnosine; D006861:Hydrogen Peroxide; D009195:Peroxidase; D010100:Oxygen