title: Basic principles of clinical pharmacology.
abstract: This article reviews basic principles of clinical pharmacology and their therapeutic application. The effects of drug absorption, distribution, protein binding metabolism, and excretion are discussed. Models for repetitive oral and intravenous dosing are presented, and the difference between pharmacokinetic and pharmacodynamic analysis emphasized. The final section reviews the effects of physiologic and pathologic processes on clinical pharmacology.
authors.affiliation: Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
authors.forename: W H
authors.initials: WH
authors.lastname: Theodore
mesh_terms: D000367:Age Factors; D006801:Humans; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical