title: [Changes in the autonomic balance of the regulation of the rate of heart contractions during physical loading in chronic suppression or potentiation of the endogenous opioidergic system in rats].
abstract: The influence of endogenous opioid system on the rat's mean blood pressure (BP) and heart rate (HS) has been studied under the chronic infusion of the opioid receptor antagonist naloxone (1 mg/kg intraperitoneally, twice a day, during 6 days) or an inhibitor of captorile enkephalinases (20 mg/kg subcutaneously). Naloxone caused a significant decrease and captorile--increase of maximum meanings of HR during exercises (the running on the treadmill during 3.5 min by the velocity of 30 m/min), both compounds didn't exert a considerable effect on BP at rest and during exercises. It has been concluded that the endogenous opioid system plays an important role in the autonomic HR regulation during exercise.
authors.forename: L D
authors.initials: LD
authors.lastname: Kuligina
authors.forename: N A
authors.initials: NA
authors.lastname: Sokolova
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: G Ia
authors.initials: GIa
authors.lastname: Shvarts
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D011674:Pulse / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone; D002216:Captopril
vernacular_title: Izmenenie vegetativnogo balansa reguliatsii chastoty serdechnykh sokrashcheniĭ v usloviiakh fizicheskoĭ nagruzki pri khronicheskom podavlenii ili potentsiatsii éndogennoĭ opioidergicheskoĭ sistemy u krys.