BCL-1 participates in the 11q13 amplification found in breast cancer.
In an attempt to probe the significance of HST and INT-2 gene amplification in human breast carcinomas, we have surveyed the amplification status of five molecular markers located on the long arm of chromosome 11 (BCL-1, HST, INT-2 & SEA on 11q13, and ETS-1 on 11q23) in a population of 297 mammary tumors. ETS-1 was rarely amplified and always independently from the other proto-oncogenes. Concerning band q13: (i) 50 tumors (approximately 17%) were co-amplified for BCL-1, HST & INT-2; (ii) in 3 cases, amplification extended to the SEA gene; (iii) in 6 carcinomas, BCL-1 was the only amplified marker. The fact that we never observed amplification of HST & INT-2 independently of BCL-1, which in turn can be amplified solely, suggests the presence, between HST/INT-2 and BCL-1, of a genetic element which could be important in the development of a subset of mammary tumors.
Theillet
C
C
CNRS URA 1191 Centre Paul Lamarque, Montpellier, France.
Adnane
J
J
Szepetowski
P
P
Simon
M P
MP
Jeanteur
P
P
Birnbaum
D
D
Gaudray
P
P
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D005260:Female; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors; D005784:Gene Amplification; D006801:Humans; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011519:Proto-Oncogenes; D011995:Recombination, Genetic
C496444:FGF3 protein, human; D051518:Fibroblast Growth Factor 3; D011518:Proto-Oncogene Proteins; D005346:Fibroblast Growth Factors