Influence of stress on phosphoinositides in rat brain.
The effect of a single 1 h immobilization or repeated 1 h immobilization for 10 days on the levels of phosphoinositides in rat whole brain was investigated. Immediately after 1 h immobilization the levels of phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2) were decreased by 22 and 31%, respectively, but phosphatidylinositol 4-phosphate (PIP) was not significantly reduced. These changes were restored to normal levels 20 h after the immobilization. After repeated daily immobilizations the effect of stress on phosphoinositides was no longer observed. These results show that acute stress perturbs the concentration of PIP2 (precursor of second messengers) and indicate adaptation to acute stress in animals subjected to repeated stress.
Subramoniam
A
A
Industrial Toxicology Research Centre, Lucknow, India.
Sharma
V P
VP
Seth
P K
PK
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D010716:Phosphatidylinositols