title: [Intra-arterial neoadjuvant chemotherapy of sarcoma of the extremities].
abstract: Since 1987 we have treated 17 patients with bone sarcomas of the extremities (14 osteosarcomas, 3 malignant fibrous histiocytomas), with 2 cycles of neoadjuvant chemotherapy, consisting in iv high dose Methotrexate, Cis-Platin in 3 days in continuous infusion, and iv Adriamycin every 29th day. We obtained "good necrosis" (greater than 90%) in 13 patients (76.5%). We briefly report the possible correlations between angiographic findings after the first cycle and response to chemotherapy. All patients but one (94%), underwent conservative surgery. To date no patients have had local recurrence; 12 patients (70.5%) are disease free at a median follow up of 21.5 months; in 5 patients lung metastases appeared. To define overall survival and disease-free survival a longer follow up is required.
authors.affiliation: Servizio di Radiodiagnostica I, Ospedale Santa Maria delle Croci, USL n.35, Ravenna.
authors.forename: G
authors.initials: G
authors.lastname: Graziani
authors.forename: T
authors.initials: T
authors.lastname: Priori
authors.forename: G
authors.initials: G
authors.lastname: Fiorentini
authors.forename: M
authors.initials: M
authors.lastname: Molinari
authors.forename: A
authors.initials: A
authors.lastname: Tienghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005121:Extremities; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009135:Muscular Diseases / Q000188:drug therapy; D012516:Osteosarcoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate
vernacular_title: Chemioterapia neoadiuvante intrarteriosa nei sarcomi degli arti.