In vivo stimulation of lung collagen synthesis by collagen derived peptides.
In the present work we examined the "in vivo" effects of collagen breakdown products derived from elastase digestion on lung collagen synthesis in rabbits. It was found that i.v. injection of collagen peptides greatly enhances the collagen synthesis rate while does not affect the synthesis of non collagenous proteins. The increase of incorporation of 3H-proline in lung collagen parallels that of prolyl hydroxylase activity. The collagen synthesis, expressed as fractional rate (% day), amounted to 15% day in treated animals, resulting in a significant increase with respect to controls (11.7% day). The observations reported provide evidence that collagen breakdown products stimulate lung collagen synthesis and may play a role in collagen homeostasis.
Pacini
A
A
Institute of General Physiology, University of Siena, Italy.
Gardi
C
C
Corradeschi
F
F
Viti
A
A
Belli
C
C
Calzoni
P
P
Lungarella
G
G
D000818:Animals; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism; D008168:Lung / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D009929:Organ Size; D010196:Pancreatic Elastase / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D011817:Rabbits
D010455:Peptides; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D010196:Pancreatic Elastase