title: Indirect inactivation of rat brain cytosolic diacylglycerol kinase by nucleoside-5'-monophosphate.
abstract: Cytosolic diacylglycerol kinase was inhibited drastically by nucleoside monophosphate. The inhibition was relatively specific for adenosine-5'-monophosphate (5'-AMP), although uridine-5'-monophosphate was also effective. The effect of 5'-AMP on diacylglycerol kinase appeared to be indirect since the degree of inhibition lessened with the dilution of the cytosol and the more purified enzyme failed to respond to 5'-AMP. A 5'-AMP-dependent mediator is proposed to be involved in the inactivation of diacylglycerol kinase.
authors.affiliation: Missouri Institute of Psychiatry, University of Missouri, Columbia.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Klemm
authors.forename: I M
authors.initials: IM
authors.lastname: Jeng
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003600:Cytosol / Q000201:enzymology; D019852:Diacylglycerol Kinase; D010770:Phosphotransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats
chemical_list: D000249:Adenosine Monophosphate; D010770:Phosphotransferases; D019852:Diacylglycerol Kinase