Carcinoma of the cervix uteri and risk factors.
A prospective study included 210 patients and 100 healthy individuals in whom risk factors for the onset of malignant disorders of the cervix uteri were investigated. The following parameters were analyzed: age, profession, religious affiliation, former pregnancies, chronic irritative process on the cervix uteri, socio-economic status, heredity, contraceptive usage, smoking, sexual life and presence of the human papilloma viruses in the injured and healthy cervix. The results of the research emphasized the relevant risk factors for the genesis of the disease. They are presented in an original sheme. The central place in the pathogenesis of the disease is taken by the existing metaplasia on the portio vaginalis uteri and its contact with definite types of human papilloma viruses. The risk factors that contribute to the genesis of metaplasia and cervical infection by human papilloma viruses proved to be of great importance for the appearance of disorder. The adolescent period, the chronic irritative process on the portio vaginalis and the long-term use of hormonal contraceptives influence the genesis of metaplasia. Early sexual life, the changing of sexual partners, the sexual life of male partners, poor sexual hygiene, and the use of nonbarrier contraceptive devices favour the development of human papilloma viral infections of the cervix uteri.
Stanimirović
B
B
Narodni Front, Department of Obstetrics and Gynecology, Belgrade, Yugoslavia.
Grob
R
R
Rüdlinger
R
R
D000328:Adult; D002584:Cervix Uteri / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008679:Metaplasia; D008875:Middle Aged; D027383:Papillomaviridae / Q000472:pathogenicity*; D011446:Prospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000382:microbiology