title: Post-exercise platelet activation--aggregation and release in relation to dynamic exercise.
abstract: Relatively scarce information is found on the period immediately following physical stress, with special reference to human platelet activity. This, in connection with earlier observations of an increase in platelet release products and hyperaggregability following surgical stress, has initiated the present study. We studied platelet function in eight healthy non-mediated volunteers during and 1 h after cycle exercise of submaximal intensity. ADP-induced platelet aggregability was enhanced in the last minute of exercise followed by a decreased aggregability 1 h after. Adrenaline-induced platelet aggregation showed the same attenuation after exercise but no change during work. The release products beta-thromboglobulin and serotonin in plasma showed significant increases after exercise. This is taken as evidence of an enhanced platelet activity following exercise. A normal stress-response, measured as increase in cyclic AMP in plasma, was observed. In conclusion, platelets are activated following moderate exercise and it seems valid to include the post-exercise period in future studies.
authors.affiliation: Department of Clinical Physiology/Nuclear Medicine, Frederiksberg Hospital, Copenhagen, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Naesh
authors.forename: I
authors.initials: I
authors.lastname: Hindberg
authors.forename: J
authors.initials: J
authors.lastname: Trap-Jensen
authors.forename: J O
authors.initials: JO
authors.lastname: Lund
mesh_terms: D000244:Adenosine Diphosphate; D000328:Adult; D000242:Cyclic AMP / Q000097:blood; D004837:Epinephrine; D006801:Humans; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D015539:Platelet Activation; D010974:Platelet Aggregation; D010976:Platelet Count; D012701:Serotonin / Q000097:blood; D013312:Stress, Physiological / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001620:beta-Thromboglobulin; D012701:Serotonin; D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D004837:Epinephrine