title: Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications.
authors.affiliation: Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: P D
authors.initials: PD
authors.lastname: Williams
authors.forename: R D
authors.initials: RD
authors.lastname: Tung
authors.forename: M G
authors.initials: MG
authors.lastname: Bock
authors.forename: D J
authors.initials: DJ
authors.lastname: Pettibone
authors.forename: B V
authors.initials: BV
authors.lastname: Clineschmidt
authors.forename: R M
authors.initials: RM
authors.lastname: DiPardo
authors.forename: J M
authors.initials: JM
authors.lastname: Erb
authors.forename: V M
authors.initials: VM
authors.lastname: Garsky
authors.forename: N P
authors.initials: NP
authors.lastname: Gould
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D007202:Indicators and Reagents; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010121:Oxytocin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects* / Q000378:metabolism; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D012995:Solubility; D013329:Structure-Activity Relationship; D014599:Uterus / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents; D010456:Peptides, Cyclic; D011945:Receptors, Angiotensin; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D010121:Oxytocin