Changed distribution of sodium channels along demyelinated axons.
Voltage-gated sodium channels are largely localized to the nodes of Ranvier in myelinated axons, providing a physiological basis for saltatory conduction. What happens to these channels in demyelinated axons is not known with certainty. Experimentally demyelinated axons were examined by using a well-characterized, polyclonal antibody directed against sodium channels. Immunocytochemical and radioimmunoassay data were consistent with the distribution of an increased number of sodium channels along segments of previously internodal axon. These findings affirm the plasticity of sodium channels in demyelinated axolemma and may be relevant to understanding how axons recover conduction after demyelination.
England
J D
JD
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262.
Gamboni
F
F
Levinson
S R
SR
Finger
T E
TE
D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002352:Carrier Proteins / Q000032:analysis; D004317:Doxorubicin / Q000494:pharmacology; D004557:Electric Organ / Q000502:physiology; D004593:Electrophorus; D006054:Goldfish; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology*; D013779:Tetrodotoxin / Q000378:metabolism
D002352:Carrier Proteins; D015222:Sodium Channels; C023790:tetrodotoxin-binding protein; D013779:Tetrodotoxin; D004317:Doxorubicin