[An evaluation of the efficacy of antiatherosclerotic agents based on a study of the peripheral blood monocytes].
Examination of the effect of calcium antagonists on the functional activity of monocytes revealed the possibility of using these cells as an object for testing antiatherosclerotic agents. The functional activity of monocytes was evaluated by their capacity of producing thromboxane B2 and by the cellular content of cyclic AMP. It is suggested that calcium antagonists verapamil and niphedipin, in particular, are potential antiatherosclerotic agents.
Glushko
L V
LV
Neĭko
E M
EM
Ermolin
G A
GA
Kameneva
A M
AM
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D005082:Physical Exertion; D013929:Thromboxane B2 / Q000097:blood
D002121:Calcium Channel Blockers; D013929:Thromboxane B2; D000242:Cyclic AMP
Otsenka éffektivnosti protivoateroskleroticheskikh sredstv na osnove issledovaniia monotsitov perifericheskoĭ krovi.