title: Localization of 3H-prazosin binding sites in the supraoptic and paraventricular nuclei of the human hypothalamus.
abstract: Using 3H-prazosin, we have examined the distribution of alpha 1-adrenergic receptors in the supraoptic and paraventricular nuclei of the human hypothalamus. Our studies show that binding sites for 3H-prazosin in human hypothalamus possess pharmacological characteristics similar to those of rat brain. Autoradiographic studies revealed discrete localization of 3H-prazosin to the paraventricular and supraoptic nuclei.
authors.affiliation: Division of Endocrinology and Metabolism, Veterans Administration Medical Center, Seattle, Wash.
authors.forename: B J
authors.initials: BJ
authors.lastname: Wilcox
authors.forename: M A
authors.initials: MA
authors.lastname: Raskind
authors.forename: G N
authors.initials: GN
authors.lastname: Ko
authors.forename: D G
authors.initials: DG
authors.lastname: Baskin
authors.forename: M
authors.initials: M
authors.lastname: Pascualy
authors.forename: D M
authors.initials: DM
authors.lastname: Dorsa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D001667:Binding, Competitive; D006801:Humans; D008297:Male; D008875:Middle Aged; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis*; D011224:Prazosin; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D013495:Supraoptic Nucleus / Q000032:analysis*
chemical_list: D011942:Receptors, Adrenergic, alpha; D011224:Prazosin