[The effect of 6-hydroxydopamine on the autogenic motor activity of newborn rat pups].
At the 1st, 2nd and 3rd days after birth, subcutaneous injections of 6-oxydopamine in physiological solution containing 0.1% of ascorbic acid have been made to rat puppies in a dose 100 mg/kg per one injection. Within first three weeks, electromyographic studies were made on outbursts of autogenic periodic motor activity which is typical of animals at this age. It was shown that at the 3rd day of postnatal life, after 6-oxydopamine administration, total duration of motor excitation is significantly lower, whereas mean duration of the outbursts of continuous activity is lower even at the 7th day. Beginning from the 10th day, these parameters undergo opposite changes at the background of the increase in the number of outbursts and the decrease of intervals between the latter. The data obtained are discussed in relation to the role of catecholaminergic systems in regulation and realization of age dynamics of autogenic motor activity.
Bursian
A V
AV
Timofeeva
O P
OP
D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D004576:Electromyography; D006892:Hydroxydopamines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D017983:Receptors, Catecholamine
D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D016627:Oxidopamine
Vliianie 6-oksidofamina na autogennuiu motornuiu aktivnost' novorozhdennykh krysiat.