Endothelin and PDGF do not stimulate peripheral blood monocyte chemotaxis, adhesion to endothelium, and superoxide production.
Endothelin is a potent vasoconstrictory endothelial-derived peptide which can induce smooth muscle proliferation and therefore may be proatherogenic. Platelet-derived growth factor is also a potent mitogenic vasoconstrictory protein which is proatherogenic. We report that neither endothelin nor PDGF stimulate superoxide production, or monocyte adhesion to porcine aortic endothelial cell monolayers; additionally endothelin is not a chemoattractant factor for monocytes. If endothelin and PDGF are important in atherogenesis it is unlikely that a monocyte response to these mediators is involved.
Bath
P M
PM
Department of Medicine, King's College School of Medicine and Dentistry, Denmark Hill, London, United Kingdom.
Mayston
S A
SA
Martin
J F
JF
D000328:Adult; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood*; D013552:Swine
D016232:Endothelins; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine