Neurokinin A is a specific and precocious inhibitor of water intake in neonatal rats.
Neurokinin A (NKA), which selectively inhibits only cellular dehydration (CD)-induced drinking in adult rats, exerts a more general antidipsogenic effect in pups in which it also inhibits drinking induced by angiotensin II (AII) or suckling deprivation (SD). The inhibition of drinking is precocious (1st-3rd day) and never involves the intake of milk. The inhibition of CD-induced drinking increases with age, while that of AII- or SD-induced drinking progressively decreases and disappears on day 12-15. In the rat, NKA is therefore a precocious and selective inhibitor of drinking behavior and its selectivity is achieved ontogenetically.
Perfumi
M
M
Institute of Pharmacology, University of Camerino, Italy.
Massi
M
M
Epstein
A N
AN
de Caro
G
G
D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D004326:Drinking / Q000502:physiology*; D005260:Female; D005508:Food Deprivation; D007276:Injections, Intraventricular; D008297:Male; D008892:Milk; D015288:Neurokinin A / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology; D014867:Water / Q000378:metabolism*
D014867:Water; D000804:Angiotensin II; D015288:Neurokinin A