title: Synthesis of mu-conotoxin GIIIA: a chemical probe for sodium channels.
abstract: mu-Conotoxin GIIIA, a 22 amino acid peptide paralytic toxin which inhibits the muscle voltage-activated sodium channels, was synthesized by a solid phase method. No purification of intermediates was necessary for the synthesis, and a simple air oxidation of the deprotected crude peptide gave the desired toxin. By all criteria applied, the synthetic material was indistinguishable from the authentic natural toxin.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: E
authors.initials: E
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaoka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D020916:Conotoxins; D004557:Electric Organ / Q000187:drug effects / Q000378:metabolism; D004593:Electrophorus; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D008978:Mollusk Venoms / Q000138:chemical synthesis*; D015222:Sodium Channels / Q000187:drug effects*
chemical_list: D020916:Conotoxins; D008978:Mollusk Venoms; D015222:Sodium Channels; C046101:conotoxin GIII