Desferrioxamine as a lipid chain-breaking antioxidant in sickle erythrocyte membranes.
The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron-induced oxidative damage has been ascribed to its ability to chelate available ferric ion (Kb = 10(31)). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non-haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.
Hartley
A
A
Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, University of London, UK.
Davies
M
M
Rice-Evans
C
C
D000755:Anemia, Sickle Cell / Q000097:blood*; D000975:Antioxidants; D003676:Deferoxamine / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood*; D008563:Membrane Lipids / Q000097:blood*; D012016:Reference Values; D013113:Spin Labels
D000975:Antioxidants; D008054:Lipid Peroxides; D008563:Membrane Lipids; D013113:Spin Labels; D007501:Iron; D003676:Deferoxamine