Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.
Yoshida
H
H
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Bogaki
M
M
Nakamura
M
M
Nakamura
S
S
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009154:Mutation
D042462:4-Quinolones; D000890:Anti-Infective Agents; D004250:DNA Topoisomerases, Type II