The homologous glucose transport proteins of prokaryotes and eukaryotes.
Genes or cDNA encoding sugar transport proteins have recently been isolated from a variety of prokaryote and eukaryote organisms. By sequencing the cloned DNA, the amino acid sequences of the transport proteins have been predicted and found to comprise a homologous family extending from cyanobacteria through yeasts, algae and protozoa to mammals, including rat, mouse and man. By aligning all the sequences and comparing them with those of membrane transport proteins for other sugars, we can deduce which features of the primary sequences are critical for maintenance of structure and function. Furthermore, the conservation of extended hydrophobic and hydrophilic regions enables the construction of a consensus model of their arrangement in the membrane. Specific sequence motifs are identified and their occurrence in otherwise apparently unrelated bacterial transport proteins for citrate and tetracycline are discussed.
Henderson
P J
PJ
Department of Biochemistry, University of Cambridge, UK.
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D016384:Consensus Sequence; D000458:Cyanobacteria / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D011387:Prokaryotic Cells / Q000378:metabolism*; D011487:Protein Conformation; D051381:Rats / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014407:Tumor Cells, Cultured / Q000378:metabolism
D001426:Bacterial Proteins; D009004:Monosaccharide Transport Proteins; D009363:Neoplasm Proteins