title: Efficacy and safety of simvastatin (alone or in association with cholestyramine). A 1-year study in 66 patients with type II hyperlipoproteinaemia.
abstract: The effects and safety of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, were investigated alone or in association with cholestyramine in 66 patients with hypercholesterolaemia, in a 1-year study. In type IIa hypercholesterolaemia (41 patients), the association was more effective than simvastatin used alone in lowering total cholesterol (37% vs 29%) and LDL-cholesterol (45% vs 37%). In type IIb hypercholesterolaemia (23 patients), the association simvastatin-cholestyramine did not appear more effective than simvastatin used alone. The decrease of apoprotein B was parallel to the LDL-cholesterol decrease. Apoprotein A1 did not change significantly. The long-term safety of simvastatin was good. No lens opacity was noted. The most serious side-effect in our study was myolysis which occurred in two patients with a marked increase in creatine phosphokinase.
authors.affiliation: Unité de recherches sur les dyslipidémies et l'athérosclérose, INSERM U 32, Hôpital Henri Mondor, Creteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Emmerich
authors.forename: I
authors.initials: I
authors.lastname: Aubert
authors.forename: B
authors.initials: B
authors.lastname: Bauduceau
authors.forename: C
authors.initials: C
authors.lastname: Dachet
authors.forename: B
authors.initials: B
authors.lastname: Chanu
authors.forename: D
authors.initials: D
authors.lastname: Erlich
authors.forename: D
authors.initials: D
authors.lastname: Gautier
authors.forename: B
authors.initials: B
authors.lastname: Jacotot
authors.forename: J
authors.initials: J
authors.lastname: Rouffy
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001059:Apoproteins / Q000378:metabolism; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019821:Simvastatin
chemical_list: D000924:Anticholesteremic Agents; D001059:Apoproteins; D008055:Lipids; D002792:Cholestyramine Resin; D008148:Lovastatin; D019821:Simvastatin