Specific alterations in different adipose tissues of pig adipocyte plasma membrane structure by dietary lipids.
The effect of dietary n-6 polyunsaturated fatty acid content on pig adipocyte plasma membrane was studied with two types of adipose tissues: subcutaneous backfat layer and perirenal fat. When pigs were fed a diet containing 15 percent sunflower oil, the n-6 polyunsaturated fatty acid content in the membranes increased in both tissues parallel to a decrease in the n-9 monounsaturated fatty acid content. An increase in membrane fluidity measured by fluorescence polarization was observed particularly in subcutaneous tissue, in spite of a higher level of some membrane rigid components: the sphingomyelin/phosphatidylcholine ratio was increased in the subcutaneous tissue, whereas the cholesterol/phospholipid ratio was increased in the perirenal one. The latter results gave evidence for a depot-dependent modification in the membrane structure by dietary lipids.
Nicolas
C
C
Laboratoire de Nutrition et Sécurité Alimentaire, INRA, Centre de Recherches de Jouy-en-Josas, France.
Demarne
Y
Y
Lecourtier
M J
MJ
Lhuillery
C
C
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology; D003579:Cytochrome Reductases / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D008041:Linoleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013552:Swine
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D013385:Succinate Dehydrogenase; D003579:Cytochrome Reductases; D009708:Nucleotidases