Sodium transport inhibitors in pregnancy-induced hypertension.
In blacks and whites of similar socioeconomic background, the incidence of pregnancy-induced hypertension (PIH) is probably the same. In underdeveloped countries, however. PIH is often a life-threatening complication of pregnancy. Recent theories as to the etiology of PIH include the suggestion that vascular tone may be increased as a result of inhibition of active sodium transport in vascular smooth muscle. This may be the result of an inhibitor of sodium transport present in the serum. The literature concerning the demonstration of endogenous sodium transport inhibitors and endogenous digoxinlike immunoreactivity (EDLI) in PIH is reviewed and discussed.
Poston
L
L
Renal Laboratory, St. Thomas' Hospital and Medical School, London, UK.
D001693:Biological Transport, Active; D044383:Black People; D001798:Blood Proteins / Q000276:immunology / Q000502:physiology; D002298:Cardenolides; D004077:Digoxin / Q000276:immunology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000208:ethnology / Q000378:metabolism*; D012503:Saponins; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase