5-HT3 receptor antagonists inhibit the response of kappa opioid receptors in the morphine-induced Straub tail [corrected].
We used the morphine-induced Straub tail to examine the actions of a 5-HT3 receptor antagonist and kappa opioid receptor agonist. The kappa opioid receptor agonist, U-50,488H (4-16 mg/kg i.p.), produced a dose-related inhibition of the tail elevation induced by morphine (10 mg/kg s.c.) in ICR male mice. ICS-205-930 (3 and 10 mg/kg i.p.) and zacopride (0.3 and 1 mg/kg i.p.), 5-HT3 receptor antagonists, attenuated the inhibitory effect of U-50,488H in a dose-dependent manner. ICS-205-930 and zacopride did not inhibit the morphine-induced Straub tail. These observations suggest that the actions of kappa opioid receptors may be modulated by 5-HT3 receptors in the morphine-induced Straub tail.
Hasegawa
Y
Y
Department of Pharmacology, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Kurachi
M
M
Okuyama
S
S
Araki
H
H
Otomo
S
S
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D012702:Serotonin Antagonists; D013116:Spinal Cord / Q000187:drug effects
D011759:Pyrrolidines; D011957:Receptors, Opioid; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D009020:Morphine