Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
Moore
K W
KW
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
Vieira
P
P
Fiorentino
D F
DF
Trounstine
M L
ML
Khan
T A
TA
Mosmann
T R
TR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D016753:Interleukin-10; D007378:Interleukins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014162:Transfection
D003062:Codon; D007378:Interleukins; D012333:RNA, Messenger; D016753:Interleukin-10