title: Production of 21-deoxyaldosterone by rat adrenal tissue in vitro: evidence for an alternative biosynthetic pathway of aldosterone.
abstract: Quartered rat adrenal glands transformed labelled 21-deoxyaldosterone into aldosterone in vitro. 21-deoxyaldosterone was released from the quartered rat adrenals in vitro in amounts 10 times lower than those of aldosterone and 18-hydroxycorticosterone. The production of all three steroids was qualitatively dependent on the same regulatory elements (electrolytes, ACTH, exogenous precursors, zonal specificity). However, quantitative differences could be observed. The results support a role for 21-deoxyaldosterone as a facultative precursor of aldosterone and indicate that the regulation of its production shows similarities to that of aldosterone.
authors.affiliation: Department of Pharmacology, University of Heidelberg, FRG.
authors.forename: S
authors.initials: S
authors.lastname: Lewicka
authors.forename: K
authors.initials: K
authors.lastname: Bige
authors.forename: K
authors.initials: K
authors.lastname: Weindel
authors.forename: J
authors.initials: J
authors.lastname: Winter
authors.forename: W
authors.initials: W
authors.lastname: Pies
authors.forename: P
authors.initials: P
authors.lastname: Vecsei
mesh_terms: D015069:18-Hydroxycorticosterone / Q000378:metabolism*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000502:physiology; D000818:Animals; D046508:Culture Techniques; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011191:Potassium Deficiency / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000172:deficiency / Q000494:pharmacology; D015384:Zona Glomerulosa / Q000378:metabolism*
chemical_list: C032486:21-deoxyaldosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D011188:Potassium