[An analysis of the 2 types of dopaminergic responses of the spinal ganglion neurons in rats].
Dopamine (1.10(-6) M/l) induced depolarization (61% of neurons), hyperpolarization (20%) and mixed responses of the rat dorsal root ganglion neurons. Depolarization caused transition of cAMP-dependent sodium channels into conductance state. Hyperpolarization induced activation of D2 dopamine receptors. These de- and hyperpolarizing responses seem to modulate electrical excitability of the rat dorsal root ganglion neurons.
Abramets
I I
II
Samoĭlovich
I M
IM
D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D000242:Cyclic AMP; D004298:Dopamine
Analiz dvukh tipov dofaminergicheskikh otvetov neĭronov spinal'nykh gangliev krys.