title: Predictors of local recurrence following conservative breast surgery and radiation therapy. The influence of tumor size.
abstract: Size of tumor has not been established as a predictor of tumor recurrence in the breast following conservative surgery and radiation therapy. We analyzed 783 patients with infiltrating carcinoma treated with simple excision and radiation therapy. Median follow-up was 91 months. Median age at diagnosis was 50 years. There was a 13% recurrence among patients with T1 lesions compared with a 12% recurrence among patients with T2 tumors. Size did not predict for local recurrence when the tumor was analyzed by 1-cm increments and whether the tumor was estrogen receptor protein positive or estrogen receptor protein negative. Patients with an extensive intraductal component had a significantly higher local recurrence rate for every tumor size compared with patients with extensive intraductal component-negative tumors. We concluded that size did not predict local recurrence.
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: T J
authors.initials: TJ
authors.lastname: Eberlein
authors.forename: J L
authors.initials: JL
authors.lastname: Connolly
authors.forename: S J
authors.initials: SJ
authors.lastname: Schnitt
authors.forename: A
authors.initials: A
authors.lastname: Recht
authors.forename: R T
authors.initials: RT
authors.lastname: Osteen
authors.forename: J R
authors.initials: JR
authors.lastname: Harris
mesh_terms: D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008408:Mastectomy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D011878:Radiotherapy; D011960:Receptors, Estrogen / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen