Anti-myeloperoxidase antibodies in systemic vasculitis.
Anti-neutrophil cytoplasmic antibodies (ANCA) are important diagnostic markers in vasculitic disorders. In a study of 164 patients with various clinical syndromes associated with vasculitis, 60 were found to have the antibody, as detected by indirect immunofluorescence; 23 had the so-called perinuclear antibody pattern, and of these, 15 had antibodies to neutrophil myeloperoxidase in an ELISA. These patients had multi-system involvement, and 14 of the 15 had histological evidence of small-vessel arteritis in the kidneys. In preliminary experiments, the isolated IgG from one patient was shown to inhibit luminol-dependent chemiluminescence of fluid phase myeloperoxidase.
Lee
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Regional Immunology Department, East Birmingham Hospital, England.
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Thompson
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D001323:Autoantibodies / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D009504:Neutrophils / Q000201:enzymology*; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D009195:Peroxidase