[Effects of taktivin on corticosterone production by a suspension of mouse adrenal gland cells].
The influence of the thymic hormone, not imported preparation, taktivin, on the corticosterone production by the mouse (females, BALB/c) isolated adrenocortical cells was investigated. Taktivin (0.08 and 2 micrograms/ml) reliably decreased corticosterone production by the intact cells. After stimulation of the cells by the adrenocorticotropin, the suppressive effect of the thymic hormone was expressed more strongly. On the background of ACTH (1.6 microIU/ml) taktivin (0.00064-0.4 microgram/ml) decreased corticosterone production to a basal level. When the cells were stimulated by ACTH (1600 microIU/ml) taktivin (0.000125-2 micrograms/ml) decreased corticosterone production to a marked degree. These facts witness the important role of taktivin polypeptide components in realization of cooperation between the immune and endocrine systems.
Ignat'eva
E V
EV
Chesnokova
V M
VM
Ivanova
L N
LN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis*; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Vliianie taktivina na produktsiiu kortikosterona suspenzieĭ kletok nadpochechnikov mysheĭ.