title: Inhibition of the cooperative adhesion of Streptococcus sanguis to hydroxylapatite.
abstract: The adhesion of Streptococcus sanguis to hydroxylapatite is a process involving several adhesins and receptors. Binding isotherms and Scatchard plots of the adhesion suggest that cooperative interactions occur at low cell densities. It was found that sulfolane, a hydrophobic-bond diluent, was capable of inhibiting the cooperative adhesion of S. sanguis to saliva-coated hydroxylapatite beads. Sodium thiocyanate, a chaotropic agent, inhibited not only cooperative adhesion, but also the adhesion thought to result from noncooperative interactions. It is suggested that strong chaotropic agents may not only inhibit adhesin-receptor complexes, but also may influence the secondary/tertiary structures of interacting species.
authors.affiliation: Academic Health Center, University of Louisville, KY 40292.
authors.forename: X H
authors.initials: XH
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Rosenberg
authors.forename: R J
authors.initials: RJ
authors.lastname: Doyle
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D003292:Convulsants / Q000494:pharmacology; D017886:Durapatite; D006882:Hydroxyapatites; D013298:Streptococcus sanguis / Q000502:physiology*; D013861:Thiocyanates / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology
chemical_list: D003292:Convulsants; D006882:Hydroxyapatites; D013861:Thiocyanates; D013876:Thiophenes; D017886:Durapatite; C031760:thiocyanate; C013693:sulfolane