title: The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
abstract: The available information on treatment of sinus histiocytosis with massive lymphadenopathy (SHML) was reviewed. Treatment is not necessary in most instances, but some patients may require surgery, radiation therapy, and/or chemotherapy because of severe disease manifestations. An ideal treatment has yet to be identified. Of the various chemotherapeutic regimens that have been tried so far, a combination of vinca alkaloid, alkylating agent, and corticosteroid appears to be the most effective.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
authors.forename: D M
authors.initials: DM
authors.lastname: Komp
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004338:Drug Combinations; D015618:Histiocytosis, Sinus / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D012042:Registries; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D004338:Drug Combinations