title: [Mechanisms of the development of immunodependent inflammation in silicosis].
abstract: Patients with uncomplicated silicosis were found to develop chronic immunodependent inflammation caused by an adjuvant effect of silica and characterized by autoimmune, histamine- and complement-dependent components. Reduced specific and non-specific antimicrobial defence underlies frequent complication of silicosis by tuberculosis and nonspecific infectious diseases of the bronchopulmonary system. A diagram showing the development of immunodependent inflammation in silicosis is presented.
authors.forename: T I
authors.initials: TI
authors.lastname: Grishina
authors.forename: O G
authors.initials: OG
authors.lastname: Alekseeva
authors.forename: N L
authors.initials: NL
authors.lastname: Aĭzina
authors.forename: A P
authors.initials: AP
authors.lastname: Volkova
authors.forename: R G
authors.initials: RG
authors.lastname: Girdo
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Loshchilov
authors.forename: V V
authors.initials: VV
authors.lastname: Sokolov
mesh_terms: D001324:Autoantigens / Q000009:adverse effects* / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D006801:Humans; D008168:Lung / Q000276:immunology*; D011791:Quartz / Q000009:adverse effects / Q000276:immunology*; D012822:Silicon Dioxide / Q000276:immunology*; D012829:Silicosis / Q000150:complications / Q000276:immunology*; D012830:Silicotuberculosis / Q000209:etiology*
chemical_list: D001324:Autoantigens; D011791:Quartz; D012822:Silicon Dioxide
vernacular_title: Mekhanizmy razvitiia immunozavisimogo vospaleniia pri silikoze.