title: Protection against lethal equine herpes virus type 1 (subtype 1) infection in hamsters by immune stimulating complexes (ISCOMs) containing the major viral glycoproteins.
abstract: An experimental ISCOM vaccine has been prepared from gradient purified equine herpes virus type 1 (EHV-1). Radiolabelling studies demonstrated that this vaccine contained all the major viral glycoproteins in relative amounts similar to those found in non-detergent disrupted viral preparations. This EHV-1 ISCOM vaccine generated fully protective responses in hamsters challenged with an otherwise lethal dose of the hamster-adapted EHV-1 strain RACH.
authors.affiliation: Department of Infectious Diseases, Animal Health Trust, Newmarket, Suffolk, UK.
authors.forename: R F
authors.initials: RF
authors.lastname: Cook
authors.forename: T
authors.initials: T
authors.lastname: O'Neill
authors.forename: E
authors.initials: E
authors.lastname: Strachan
authors.forename: B
authors.initials: B
authors.lastname: Sundquist
authors.forename: J A
authors.initials: JA
authors.lastname: Mumford
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D006224:Cricetinae; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D008647:Mesocricetus; D008854:Microscopy, Electron; D011863:Radioimmunoassay; D014611:Vaccination; D014765:Viral Vaccines / Q000302:isolation & purification*
chemical_list: D000276:Adjuvants, Immunologic; D006023:Glycoproteins; D014765:Viral Vaccines