[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied. The total incidence of malignant tumours in rats with pseudopregnancy, single pregnancy, pregnancy and lactation, repeated pregnancies was lower in comparison with virgin animals (75, 44, 68, 59 and 93%, respectively). Colon adenocarcinoma incidence in rats with single pregnancy or repeated pregnancies was lower than that in virgin rats (42, 49 and 76%, respectively). Protective effect was observed mainly in descending colon. The mesenchymal kidney tumours were not developed at all in rats with single pregnancy. In virgin animals it was 31%. The inhibition of tumour incidence in the liver (cholangioma, cholangiocellular carcinoma) was observed in rats with single pregnancy or pregnancy and lactation in comparison with virgin control (3, 5 and 24%, respectively).
Napalkov
N P
NP
Mikheev
A M
AM
Blinova
G A
GA
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced / Q000503:physiopathology; D002759:Adenoma, Bile Duct / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000503:physiopathology; D004127:Dimethylhydrazines; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000503:physiopathology; D007774:Lactation; D008113:Liver Neoplasms / Q000139:chemically induced / Q000503:physiopathology; D008637:Mesenchymoma / Q000139:chemically induced / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D010298:Parity; D011247:Pregnancy; D011555:Pseudopregnancy; D051381:Rats
D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine
Modifitsiruiushchee vliianie izmeneniĭ, sviazannykh s beremennost'iu, na kantserogenez, indutsirovannyĭ 1,2-dimetilgidrazinom, u krys.