In situ binding of bouton zinc reversibly disrupts performance on a spatial memory task.
Neurons with zinc in the presynaptic vesicles innervate much of the telencephalon, but the functional significance of the vesicular zinc has never been established. The present work shows that reversible binding of zinc by drug infusion into the hippocampus produces a time-locked and selective disruption of hippocampal-dependent spatial-working memory. A role for vesicular zinc in neurotransmission or neuromodulation is implied.
Frederickson
R E
RE
Laboratory for Neurobiology, University of Texas, Dallas, Richardson 75080.
Frederickson
C J
CJ
Danscher
G
G
D000818:Animals; D001369:Axons / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology*; D004050:Ditiocarb / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004924:Escape Reaction / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology; D013550:Swimming; D013572:Synaptic Vesicles / Q000187:drug effects / Q000502:physiology*; D015032:Zinc / Q000502:physiology*
D004050:Ditiocarb; D004492:Edetic Acid; D015032:Zinc