Xanthine oxidase generation of toxic oxygen metabolites in acute uveitis.
Lodoxamide, a xanthine oxidase inhibitor, has antiphlogistic effects in the treatment of acute uveitis. The role of xanthine oxidase generated free radicals is discussed.
Marak
G E
GE
Center for Sight, Georgetown University, Washington, D.C.
Till
G O
GO
Ward
P A
PA
D000818:Animals; D004195:Disease Models, Animal; D004341:Drug Evaluation; D009877:Endophthalmitis / Q000188:drug therapy / Q000378:metabolism; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013481:Superoxides / Q000378:metabolism*; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D013481:Superoxides; D014969:Xanthine Oxidase; D010072:Oxamic Acid; C021702:lodoxamide ethyl