title: Variation in intracellular P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) in virus-infected cells.
abstract: The effect of virus infection on the intracellular concentration of the proposed stress alarmone P1P4-bis(5'-adenosyl) tetraphosphate (Ap4A) has been examined in Vero cells. Compared with exposure to 0.8 mM-Cd2+, which causes a 30-fold increase in Ap4A, infection with simian virus 40 and poliovirus causes only a 2-fold increase, whereas herpes simplex virus type 1 results in a decrease in Ap4A during the course of the infection.
authors.affiliation: Department of Biochemistry, University of Liverpool, U.K.
authors.forename: D J
authors.initials: DJ
authors.lastname: Johnston
authors.forename: C A
authors.initials: CA
authors.lastname: Hart
authors.forename: A G
authors.initials: AG
authors.lastname: McLennan
mesh_terms: D000818:Animals; D015226:Dinucleoside Phosphates / Q000378:metabolism*; D017955:Poliovirus / Q000502:physiology*; D013539:Simian virus 40 / Q000502:physiology*; D018139:Simplexvirus / Q000502:physiology*; D014709:Vero Cells; D014779:Virus Replication
chemical_list: D015226:Dinucleoside Phosphates; C020733:diadenosine tetraphosphate