title: Effect of perchlorate on mitochondrial function.
abstract: Administration of sodium perchlorate to rats for 45 days leads to decreased activities of citric acid cycle enzymes. The oxidation of succinate both in state 3 and state 4 conditions and endogenous ATP content of mitochondria decreased during perchlorate toxicity. The significant decrease in cytochrome aa3 in perchlorate-treated rats may be one of the prime factors involved in the decreased rate of respiration. The permeability of mitochondria of perchlorate-treated rats is altered as indicated by increased oxidation of NADH and low respiratory control ratio (RCR).
authors.affiliation: Department of Biochemistry, University of Madras.
authors.forename: K
authors.initials: K
authors.lastname: Vijayalakshmi
authors.forename: D B
authors.initials: DB
authors.lastname: Motlag
mesh_terms: D000818:Animals; D007668:Kidney / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects; D010472:Perchlorates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010472:Perchlorates