title: [Carrier detection and prenatal diagnosis of Duchenne's muscular dystrophy based on DNA analysis].
abstract: Seven families with histories of Duchenne's muscular dystrophy underwent DNA diagnosis. The daughters of those consulted were examined for the carriage in 4 families. Their carriage was rejected or confirmed. Prenatal diagnosis was made in 2 families. In another family an abortion preceded obtaining molecular-genetic evidence. Probes 754, p20, XJI.I and primers for amplification of the site pERI87-15 containing a polymorphic locus were employed. The genetic risk was assessed using the computer program GenRisk adjusted for family history and DNA test allowances.
authors.forename: O V
authors.initials: OV
authors.lastname: Evgrafov
authors.forename: L O
authors.initials: LO
authors.lastname: Badalian
authors.forename: A V
authors.initials: AV
authors.lastname: Poliakov
authors.forename: S P
authors.initials: SP
authors.lastname: Zaĭtseva
authors.forename: N A
authors.initials: NA
authors.lastname: Malygina
authors.forename: S V
authors.initials: SV
authors.lastname: Vinogradov
authors.forename: V A
authors.initials: VA
authors.lastname: Bakharev
authors.forename: F A
authors.initials: FA
authors.lastname: Mil'man
authors.forename: L P
authors.initials: LP
authors.lastname: Lisova
authors.forename: N V
authors.initials: NV
authors.lastname: Zaretskaia
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D015342:DNA Probes; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014960:X Chromosome / Q000648:ultrastructure
chemical_list: D015342:DNA Probes
vernacular_title: Ustanovlenie nositel'stva i prenatal'naia diagnostika miodistrofii Diushenna na osnove analiza DNK.