[Synthesis and antihypertensive activity of some phenoxyalkylamine compounds].
Nine new compounds were synthesized and tested for their alpha-adrenoceptor affinity and antihypertensive activity together with 5 other previously reported compounds. Compounds I, IIa, IIb and IIIa showed high alpha-adrenoceptor affinity and strong antihypertensive activity.
Xia
L
L
China Pharmaceutical University, Naning.
Ni
P Z
PZ
Song
W
W
Liu
G Q
GQ
Qian
J Q
JQ
Li
P
P
Du
F H
FH
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D008801:Mexiletine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D000959:Antihypertensive Agents; D005021:Ethylamines; D011942:Receptors, Adrenergic, alpha; D008801:Mexiletine