[Anticoagulant therapy in obstetrical disorders].
Three kinds of anticoagulant therapy for obstetrical DIC were studied. 1. Antithrombin-III (AT) or gabexate mesilate for acute DIC, mainly for abruptio placentae. 2. Heparin or heparin-AT combination therapy for toxemia pregnancy. 3. Low molecular weight heparin (LMWH) for fetus of intrauterine growth retardation (IUGR). The results obtained were as follows, 1. a) Platelet count, and fibrinogen were significantly increased in AT therapy group compared with gabexate mesilate group. b) In clinical manifestation, renal failure and hemorrhagic diathesis were improved especially in AT group. 2. In heparin-AT group, high systolic blood pressure was improved during administration of AT, the high level of thrombin antithrombin complex was also found in these period. 3. a) The improvement of the gain of estimated fetal body weight was found after administration of LMWH. b) Redistribution of blood flow in one case of severe IUGR was observed during administration of LMWH.
Murata
M
M
Department of Obstetrics and Gynecology, Akita University School of Medicine.
Hayakawa
M
M
Goto
K
K
Isobe
K
K
Matuura
T
T
Hirano
H
H
Higuchi
M
M
Maki
M
M
D000990:Antithrombin III / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy*; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*
D006146:Guanidines; D006495:Heparin, Low-Molecular-Weight; D016670:Gabexate; D000990:Antithrombin III