Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage.
The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.
Alafaci
C
C
Department of Experimental Research, University of Lund, Sweden.
Jansen
I
I
Arbab
M A
MA
Shiokawa
Y
Y
Svendgaard
N A
NA
Edvinsson
L
L
D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology; D066298:In Vitro Techniques; D010455:Peptides / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents
D016232:Endothelins; D010455:Peptides; D014662:Vasoconstrictor Agents