The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain.
1. Two week chronic administration of trimipramine increased the brain concentration and metabolism of dopamine and 5-hydroxytryptamine. 2. The treatment also produced a reduction in dopamine D2 and 5-hydroxytryptamine 5-HT2 receptors but no change in tryptamine binding was observed. 3. These findings suggest that trimipramine induces adaptive changes in dopamine and 5-hydroxytryptamine neurotransmission.
Juorio
A V
AV
Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
Li
X M
XM
Boulton
A A
AA
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D014299:Trimipramine / Q000494:pharmacology*; D014363:Tryptamines / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D001679:Biogenic Amines; D009419:Nerve Tissue Proteins; D011985:Receptors, Serotonin; D014363:Tryptamines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; C030820:tryptamine; D014299:Trimipramine; D014364:Tryptophan; D004298:Dopamine; D006719:Homovanillic Acid