Prenatal alcohol exposure alters the development of sympathetic synaptic components and of nerve growth factor receptor expression selectivity in lymphoid organs.
Exposure to alcohol in utero has been associated with long-term immune deficits. In addition, adult mice exposed to alcohol prenatally display altered noradrenergic synaptic transmission selectively in lymphoid organs. This is consistent with the hypothesis that sympathetic neurons play an important role in immunomodulation. The development and maintenance of sympathetic neurons are critically dependent on nerve growth factor (NGF). Furthermore, NGF has been shown to modulate immune responses and NGF receptor expression has been localized to lymphoid organs. The present work examined the effects of prenatal alcohol exposure on the development and maturation of pre- and postsynaptic sympathetic components, including norepinephrine and beta-adrenoceptors, respectively, as well as the early expression of NGF receptors in lymphoid and other organs of the C57BL/6 mouse. Infant mice that were exposed to alcohol in utero displayed reduced levels of norepinephrine and beta-adrenoceptor density, as well as increased NGF receptor expression in the thymus and spleen, but not the heart. These selective changes may account, in part, for the persistent immune incompetence characteristic of fetal alcohol syndrome.
Gottesfeld
Z
Z
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Morgan
B
B
Perez-Polo
J R
JR
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D008221:Lymphoid Tissue / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000254:growth & development; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
D009414:Nerve Growth Factors; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D000431:Ethanol; D009638:Norepinephrine