Clinical pharmacokinetics of daptomycin.
Daptomycin is a new lipopeptide antibiotic for which preliminary pharmacokinetic data in adults have been limited to normal healthy volunteers and patients with renal insufficiency. We report the clinical pharmacokinetics of the first and fifth doses of iv daptomycin 150 mg (2 mg/kg) q24h in a 29-year-old man being treated for a gram-positive cellulitis and thrombophlebitis. Individual pharmacokinetic parameters yielded similar results during doses one and five. The pharmacokinetic profile observed in our patient did not markedly differ from data obtained from healthy volunteers.
Pryka
R D
RD
Clinical Pharmacokinetics and Infectious Diseases, College of Pharmacy, University of Toledo, OH.
Novak
R M
RM
Wagner
D K
DK
Rodvold
K A
KA
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D017576:Daptomycin; D006094:Gram-Positive Bacteria; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D010455:Peptides / Q000493:pharmacokinetics / Q000627:therapeutic use
D010455:Peptides; D017576:Daptomycin