Antinociceptive activity of muscarinomimetic agents.
The effect of the agents with muscarinomimetic activity on the nociceptive transmission in the spinal cord was studied in spinal rats. Oxotremorine (5-20 micrograms/kg, i.v.), arecoline (0.25-1.0 mg/kg, i.v.), pilocarpine (5-20 mg/kg, i.v.) and aceclidine (0.25-1.0 mg/kg, i.v.) inhibited the nociceptive flexor reflex induced by intraarterial injection of bradykinin. Muscarinomimetics in the same doses and anticholinesterase agents physostigmine (1-4 micrograms, intrathecally) and galanthamine (25-100 micrograms, intrathecally) inhibited bradykinin-induced bioelectric activity in the spinal ventrolateral tracts. Atropine (1 mg/kg, i.v.) abolished the inhibitory effect of the agents tested on the nociceptive flexor reflex and bioelectric activity.
Kharkevich
D A
DA
Department of Pharmacology, First Moscow Medical Institute, USSR.
Nemirovsky AYu
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001920:Bradykinin / Q000633:toxicity; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects*
D010276:Parasympatholytics; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; D001920:Bradykinin