Recurrent spleen enlargement during cyclic granulocyte-macrophage colony-stimulating factor therapy for myelodysplastic syndrome.
A 65-year-old woman with refractory anemia with excess of blasts received sequential courses of granulocyte-macrophage colony-stimulating factor therapy (GM-CSF) and low-dose cytosine arabinoside. Each course of GM-CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen.
Delmer
A
A
Service d'Hématologie, Hôtel-Dieu, Paris, France.
Karmochkine
M
M
Cadiou
M
M
Gerhartz
H
H
Zittoun
R
R
D000368:Aged; D003115:Colony-Stimulating Factors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003561:Cytarabine / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007205:Indium Radioisotopes; D007938:Leukemia / Q000209:etiology; D008213:Lymphocyte Activation / Q000187:drug effects; D009190:Myelodysplastic Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D013163:Splenomegaly / Q000209:etiology* / Q000503:physiopathology
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007205:Indium Radioisotopes; D003561:Cytarabine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor