title: [Effects of antacids on absorption, excretion and metabolism of cefteram pivoxil].
abstract: Effects of various antacids (sodium bicarbonate, aluminium hydroxide gel) and an H2-blocker (cimetidine) on the absorption and excretion of a new cephem drug for oral use, cefteram pivoxil (CFTM-PI), were studied in healthy adult volunteers. 1. No significant differences were found in serum levels of CFTM and CFTM-A (an inactive isomer of cefteram (CFTM)) or their urinary excretion levels (concentration, recovery rate) between the group given CFTM-PI in combination with sodium bicarbonate and that given CFTM-PI alone. 2. There were no significant differences in serum levels of CFTM and CFTM-A or their urinary excretion levels (concentration, recovery rate) between the group given CFTM-PI in combination with aluminium hydroxide gel and that given CFTM-PI alone. 3. In contrast, serum levels of CFTM and its urinary recovery rate were significantly less in the group given the drug in combination with cimetidine than in that given a single administration 2-3.5 hours and 2-4 hours after administration, respectively. Clinical considerations remain.
authors.affiliation: 2nd Department of Internal Medicine, Jikei University School of Medicine.
authors.forename: J
authors.initials: J
authors.lastname: Shimada
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Shiba
authors.forename: M
authors.initials: M
authors.lastname: Kaji
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Miyahara
mesh_terms: D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001639:Bicarbonates / Q000008:administration & dosage / Q000494:pharmacology; D015281:Cefmenoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D008297:Male; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology; D017693:Sodium Bicarbonate
chemical_list: D000900:Anti-Bacterial Agents; D001639:Bicarbonates; C046817:cefteram pivoxil; D000536:Aluminum Hydroxide; D002927:Cimetidine; D017693:Sodium Bicarbonate; D012964:Sodium; D015281:Cefmenoxime