title: Biomedical irradiation system for boron neutron capture therapy at the Kyoto University Reactor.
abstract: Physics studies related to radiation source, spectroscopy, beam quality, dosimetry, and biomedical applications using the Kyoto University Reactor Heavy Water Facility are described. Also, described are a Nickel Mirror Neutron Guide Tube and a Super Mirror Neutron Guide Tube that are used both for the measurement of boron concentration in phantom and living tissue and for precise measurements of neutron flux in phantom in the presence of both light and heavy water. Discussed are: (1) spectrum measurements using the time of flight technique, (2) the elimination of gamma rays and fast neutrons from a thermal neutron irradiation field, (3) neutron collimation without producing secondary gamma rays, (4) precise neutron flux measurements, dose estimation, and the measurement of boron concentration in tumor and its periphery using guide tubes, (5) the dose estimation of boron-10 for the first melanoma patient, and (6) special-purpose biological irradiation equipment. Other related subjects are also described.
authors.affiliation: Kyoto University Research Reactor Institute, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Kanda
authors.forename: Y
authors.initials: Y
authors.lastname: Ujeno
authors.forename: M R
authors.initials: MR
authors.lastname: Ishida
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D001896:Boron Compounds / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003903:Deuterium; D017666:Deuterium Oxide; D006801:Humans; D008961:Models, Structural; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D009502:Neutrons / Q000627:therapeutic use*; D009688:Nuclear Reactors; D011835:Radiation Protection; D011879:Radiotherapy Dosage; D012985:Software Design; D014867:Water
chemical_list: D001896:Boron Compounds; D014867:Water; D003903:Deuterium; D017666:Deuterium Oxide