Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat.
Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.
Galzigna
L
L
Department of Biological Chemistry, University of Padova, Italy.
Bianchi
M
M
Rizzoli
V
V
Scuri
R
R
Giannetti
P
P
Paesano
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D000431:Ethanol / Q000037:antagonists & inhibitors*; D005635:Fructosediphosphates / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010437:Peptic Ulcer / Q000517:prevention & control; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D000637:Transaminases / Q000097:blood
D002712:Chlorides; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D011963:Receptors, GABA-A; D010758:Phosphorus; D000431:Ethanol; D000637:Transaminases; C029063:fructose-1,6-diphosphate; D002118:Calcium