title: The dose rate effects on the in vitro radiolysis products of magnesium-guanosine-5'-monophosphate complexes in aqueous solutions.
abstract: This study examined the effects on the radiolysis of magnesium-guanosine-5'-monophosphate complexes in deaerated aqueous solutions, investigated by Fourier transform infrared (FT-IR) spectroscopy. It was found that when the system was irradiated with a dose rate of 500 rad/min (low dose rate), the OH radicals, H atoms and hydrated electrons (eaq-) produced from radiolysis of water reacted mainly by addition to the double bonds C4 = C5 and N7 = C8 of guanine. When the dose rate was 23,800 rad/min (high dose rate) the electrons reacted further with the complex by addition to the carbonyl group, C6 = O, of guanine.
authors.affiliation: National Technical University of Athens, Laboratory of Radiation Chemistry and Biospectroscopy, Greece.
authors.forename: J D
authors.initials: JD
authors.lastname: Anastassopoulou
authors.forename: N T
authors.initials: NT
authors.lastname: Rakintzis
authors.forename: T
authors.initials: T
authors.lastname: Theophanides
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005583:Fourier Analysis; D005720:Gamma Rays; D006150:Guanine Nucleotides / Q000528:radiation effects*; D006157:Guanosine Monophosphate / Q000528:radiation effects*; D008274:Magnesium / Q000528:radiation effects*; D017616:Magnesium Compounds; D015394:Molecular Structure; D010472:Perchlorates; D012996:Solutions; D013055:Spectrophotometry, Infrared; D014867:Water
chemical_list: D003037:Cobalt Radioisotopes; D006150:Guanine Nucleotides; D017616:Magnesium Compounds; D010472:Perchlorates; D012996:Solutions; D014867:Water; C016547:magnesium perchlorate; D006157:Guanosine Monophosphate; D008274:Magnesium