Acute leukemia/lymphoma of plasmacytoid T-cell type.
Plasmacytic morphologic characteristics are usually associated with cells of B-lymphocyte origin. Recently, plasmacytoid T-cells have been described in reactive lymph nodes and a rare form of lymphoma characteristically associated with myeloproliferative disorders. This report documents a case of plasmacytoid T-cell malignancy that initially presented as an acute leukemia in an elderly man with a longstanding myelodysplastic syndrome. The tumor replaced bone marrow and involved lymph nodes. Despite aggressive therapy, he died quickly of his leukemia/lymphoma. This case illustrates the need for complete cellular analysis in the diagnosis of morphologically plasmacytic malignancies and raises additional questions about the relationship of this peculiar type of T-cell to the hematopoietic marrow.
Caldwell
C W
CW
Department of Pathology and Medicine, University of Missouri School of Medicine, Columbia 65212.
Yesus
Y W
YW
Loy
T S
TS
Bickel
J T
JT
Perry
M C
MC
D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000235:genetics; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D007952:Leukemia, Plasma Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D004273:DNA, Neoplasm; D000135:Acid Phosphatase