title: Gastrointestinal regulatory peptides in familial adenomatous polyposis.
abstract: The etiology of adenomas in the stomach and duodenum in patients with familial adenomatous polyposis (FAP) is unknown. In this study the plasma concentration of epidermal growth factor (EGF), and other gastrointestinal polypeptides with a possible trophic effect on the gastrointestinal mucosa, was unchanged before and after meal stimulation. In 3 of 7 patients an increased EGF immunoreactivity was found in duodenal adenomas. This study has not indicated that regulatory peptides are involved in development of duodenal polyps in FAP, but suggests further studies to determine the role of EGF in FAP.
authors.affiliation: Department of Surgery C, Rigshospitalet, Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Skov Olsen
authors.forename: S
authors.initials: S
authors.lastname: Bülow
authors.forename: P N
authors.initials: PN
authors.lastname: Jørgensen
authors.forename: S
authors.initials: S
authors.lastname: Seier Poulsen
authors.forename: E
authors.initials: E
authors.lastname: Nexø
mesh_terms: D000236:Adenoma / Q000097:blood / Q000473:pathology; D011125:Adenomatous Polyposis Coli / Q000097:blood*; D000328:Adult; D004379:Duodenal Neoplasms / Q000097:blood / Q000473:pathology; D004815:Epidermal Growth Factor / Q000097:blood; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000473:pathology; D007417:Intestinal Polyps / Q000097:blood / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood* / Q000652:urine
chemical_list: D005768:Gastrointestinal Hormones; D010455:Peptides; D004815:Epidermal Growth Factor