Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats.
The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.
Koch
M J
MJ
Department of Anatomy, University of Mainz, Federal Republic of Germany.
Biesalski
H K
HK
Stofft
E
E
Weiser
H
H
Gabbert
H E
HE
Dienes
H P
HP
Schulz-Dobrick
B
B
Bässler
K H
KH
D000818:Animals; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007583:Jejunum / Q000378:metabolism / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014802:Vitamin A Deficiency / Q000473:pathology*