[The effects of aqueous extracts of Raphanus niger on an experimental influenza infection in mice and on the enzyme polymorphism in lung tissue extracts].
Prophylactic effects of Raphanus niger water extract against A/PR 8/34 influenza virus experimental infection was tested in mice, by means of the following parameters: mortality mean survival time and hemagglutinating (HA) titre of lung extract. Variations of the isoenzymatic structures of peroxidase and acid and alkaline phosphatases were studied too. The results revealed the significant reduction of mortality and of hemagglutinating titre and the augmentation of mean survival time. Modifications of the isoenzymatic structures, especially of the phosphatases, are characteristic for the illness state as well as for the one induced by R. niger extract treatment.
Prahoveanu
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E
Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
Eşanu
V
V
D000135:Acid Phosphatase / Q000032:analysis / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000032:analysis / Q000187:drug effects; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004591:Electrophoresis, Polyacrylamide Gel; D007527:Isoenzymes / Q000032:analysis / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000201:enzymology / Q000401:mortality / Q000517:prevention & control*; D009195:Peroxidase / Q000032:analysis / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal
D000998:Antiviral Agents; D007527:Isoenzymes; D010936:Plant Extracts; D009195:Peroxidase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Les effets d'un extrait aqueux de Raphanus niger sur l'infection expérimentale à virus de la grippe chez la souris et sur le polymorphisme de quelques enzymes dans les extraits de tissu pulmonaire.