[The effect of cholino- and adrenoblockers on limbic-sympathetic evoked potentials].
Effects of i.v. administration of cholino- and adrenergic blocking agents on limbic-sympathetic discharges of L2-L3 white rami, evoked by stimulation of the anterior, visceral area of the limbic cortex and on arterial blood pressure were studied in anesthetized cats. M- and N-cholinoreceptor blocking agents atropine and ganglerone do not induce any apparent changes in limbic-sympathetic discharge and the blood pressure level. Beta-adrenoreceptor blocking agent propranolol evoked a small fall of the blood pressure with no apparent changes of limbic-sympathetic discharges. Alpha-adrenoreceptor blocking agent phenotolamine evoked obvious drop of the blood pressure and, in two out of eight experiments, a marked increase of the amplitude of limbic-sympathetic evoked discharges. Neurochemical regulatory mechanism of limbic-spinal sympathetic activity are discussed.
Baklavadzhian
O I
OI
Eganova
V S
VS
Kasparova
S R
SR
Khudoian
E A
EA
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D008032:Limbic System / Q000187:drug effects* / Q000502:physiology; D008839:Microelectrodes; D010276:Parasympatholytics / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors
D001565:Benzoates; D010276:Parasympatholytics; D013565:Sympatholytics; D001285:Atropine; D011433:Propranolol; C007824:ganglerone; D010646:Phentolamine
Issledovanie vliianiia kholino- i adrenoblokatorov na limbiko-simpaticheskie vyzvannye potentsialy.