Pumilacidin, a complex of new antiviral antibiotics. Production, isolation, chemical properties, structure and biological activity.
New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a beta-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamic acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K(+)-ATPase and demonstrated antiulcer activity in rat.
Naruse
N
N
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Tenmyo
O
O
Kobaru
S
S
Kamei
H
H
Miyaki
T
T
Konishi
M
M
Oki
T
T
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001407:Bacillus / Q000145:classification / Q000378:metabolism*; D002845:Chromatography; D004195:Disease Models, Animal; D005285:Fermentation; D017506:H(+)-K(+)-Exchanging ATPase; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D018139:Simplexvirus / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013276:Stomach Ulcer / Q000517:prevention & control; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D010455:Peptides; D010456:Peptides, Cyclic; C063729:pumilacidin; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase