[Parathyroid hormone stimulation of nerve cell calcium conduction].
Parathyroid hormone (PTH) has been studied for its effect on the voltage-sensitive calcium channels in voltage-clamp experiments on intracellularly perfused snail neurons. A two-stage action of the hormone on the calcium current (Ica) was shown. An initial stage was a short-term one and consisted in an increase of ICa by 7-10%. The second stage developed slowly for 60-70 min, ICa increased twice. The exogenous cAMP and cGMP did not produce such an effect as PTH did. It is suggested that the phosphoinositide pathway mediates the PTH effect.
Kostiuk
P G
PG
Luk'ianets
E A
EA
Ter-Markosian
A S
AS
Khudaverdian
D N
DN
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D015220:Calcium Channels; D010281:Parathyroid Hormone; D000242:Cyclic AMP; D006152:Cyclic GMP
Stimuliatsiia paratireoidnym gormonom kal'tsievoĭ provodimosti nervnykh kletok.