title: Stability of conjugative and non-conjugative R-plasmids from Serratia marcescens to gyrase inhibitors.
abstract: The stability of conjugative and non-conjugative R-plasmids was compared using two gyrase inhibitors (novobiocin and ciprofloxacin). Conjugative R-plasmids from eighteen ticarcillin resistant Serratia marcescens were more stable than non-conjugative R-plasmids from eleven ticarcillin resistant bacteria of the same species. Moreover, novobiocin (gyrase B sub-unit inhibitor) is a better curing agent than ciprofloxacin (A sub-unit inhibitor).
authors.affiliation: Bactériologie, Centre National de la Recherche Scientifique, Faculté de Médecine, Besançon, France.
authors.forename: C
authors.initials: C
authors.lastname: Llanes
authors.forename: Y
authors.initials: Y
authors.lastname: Michel-Briand
authors.forename: M
authors.initials: M
authors.lastname: Thouverez
authors.forename: C
authors.initials: C
authors.lastname: Bailly
authors.forename: F
authors.initials: F
authors.lastname: Grimont
mesh_terms: D002939:Ciprofloxacin / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000378:metabolism; D009675:Novobiocin / Q000494:pharmacology*; D011815:R Factors / Q000187:drug effects*; D012706:Serratia marcescens / Q000187:drug effects / Q000235:genetics*; D059005:Topoisomerase II Inhibitors
chemical_list: D004269:DNA, Bacterial; D059005:Topoisomerase II Inhibitors; D009675:Novobiocin; D002939:Ciprofloxacin