[Incidence and prognostic value of cytomegalovirus-specific antibodies of the IgM class in kidney transplant recipients].
In a retrospective study of 326 patients which have been received a renal allograft between 1985 and 1988 at the Berlin Kidney Transplant Centre, all recipients were divided into 3 groups according to their antibody status against cytomegalovirus (IgM+/IgG+; IgM-/IgG+; IgM-/IgG-). Frequency and severity of CMV infections in the early period after kidney transplantation have been compared. Primary infections could be observed in 51/112 (45.5%) patients (group 3), secondary infections in 60/190 (31.6%) patients (group 2). In 7.4% of all recipients (24/326) CMV-specific IgM antibodies could be found at the time of transplantation (group 1). In primary infections the patients have had a significantly higher frequency of moderate or severe CMV diseases as in secondary infections (24.4 vs. 8.3%). In group 3 this frequency was 16.7%. In conclusion, it is not necessary to select renal allograft recipients according their positive CMV-IgM-antibody status, but a close-meshed posttransplant control is indicated.
Eichler
C
C
Abteilung für experimentelle Organtransplantation, Bereiches Medizin (Charité), Humboldt-Universität zu Berlin.
Kaden
J
J
May
G
G
D000914:Antibodies, Viral / Q000032:analysis*; D000918:Antibody Specificity / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis*; D016030:Kidney Transplantation / Q000276:immunology*; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology; D014019:Tissue Donors
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Häufigkeit und prognostische Wertigkeit von Cytomegalievirus-spezifischen Antikörpern der Klasse IgM bei Nierentransplantatempfängern.