Effects of insulin on human beta-adrenoceptors.
The effect of insulin on beta-adrenoceptor stimulation and binding in mononuclear leucocytes from healthy subjects was studied. After 1 min exposure to insulin, the sensitivity and maximum response to (-)-isoprenaline and the number of beta-adrenoceptors increased. After 35 min exposure to insulin, the sensitivity and maximal response to (-)-isoprenaline stimulation were lower than the pretreatment values. The beta-adrenoceptor density was similar to the control value after 35 min exposure to insulin. The present observations may account for some of the cardiovascular effects of insulin.
Sager
G
G
Department of Pharmacology, University of Tromsø, Norway.
D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D007328:Insulin; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D007545:Isoproterenol