[Changes in the lungs and pleura following chemoembolization of liver tumors with mitomycin-lipiodol].
The authors performed 68 liver embolizations in 51 patients. As selectively as possible, Lipiodol, to block the capillary bed, and a chemotherapeutic agent were injected into the liver tumors. A CT performed 24 hours after treatment showed the distribution of the contrast medium which is also an indicator of the distribution of the chemotherapeutic agents. It was found that the contrast medium had accumulated not only in the liver but also in the lungs. Here, four different degrees of accumulation were found, according to the amount of Lipiodol used. Embolization of the liver thus involves potential hazards for the lungs, such as microembolisms, pneumonia, and toxic effects of the chemotherapeutic agents.
Lörcher
U
U
Klinikum JWG-Universität, Zentrum der Radiologie, Frankfurt.
Peters
J
J
Kollath
J
J
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy; D003110:Colonic Neoplasms / Q000628:therapy; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010994:Pleura / Q000187:drug effects* / Q000378:metabolism
D008937:Mitomycins; D007459:Iodized Oil
Veränderungen der Lunge und Pleura nach Chemoembolisation von Lebertumoren mit Mitomycin-Lipiodol.