title: Production of humoral factors that stimulate spleen colony-forming units in mice irradiated with moderate doses of X rays.
abstract: The production of humoral factors that stimulate spleen colony-forming units (CFU-S) has been studied in irradiated mice using an in vivo diffusion chamber assay. The experiments show that a significant release of factors that stimulate CFU-S takes place in the first few days after irradiation with moderate doses of 1.5 or 5 Gy. In contrast, the release of significant amounts of these humoral factors was not seen in animals irradiated with either low (0.75 Gy) or high (10 Gy) doses of X rays. The correlation observed between the production of factors that stimulate the CFU-S and the hemopoietic regeneration kinetics of the irradiated mice suggests that these factors represent part of the physiological regulators controlling the proliferation of CFU-S.
authors.affiliation: Unidad de Biología Molecular y Celular, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Grande
authors.forename: J
authors.initials: J
authors.lastname: González
authors.forename: C
authors.initials: C
authors.lastname: Tejero
authors.forename: G
authors.initials: G
authors.lastname: Maganto
authors.forename: J A
authors.initials: JA
authors.lastname: Bueren
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D002455:Cell Division / Q000528:radiation effects; D015194:Diffusion Chambers, Culture; D004731:Endotoxins / Q000097:blood; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011829:Radiation Dosage; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*; D013234:Stem Cells / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014916:Whole-Body Irradiation
chemical_list: D000906:Antibodies; D004731:Endotoxins; D013936:Thymidine