title: D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.
abstract: In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.
authors.affiliation: CNS Diseases Research, G.D. Searle & Company St. Louis, MO 63198.
authors.forename: G B
authors.initials: GB
authors.lastname: Watson
authors.forename: M A
authors.initials: MA
authors.lastname: Bolanowski
authors.forename: M P
authors.initials: MP
authors.lastname: Baganoff
authors.forename: C L
authors.initials: CL
authors.lastname: Deppeler
authors.forename: T H
authors.initials: TH
authors.lastname: Lanthorn
mesh_terms: D000818:Animals; D003523:Cycloserine / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D011760:Pyrrolidinones / Q000494:pharmacology; D012333:RNA, Messenger; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D014982:Xenopus laevis
chemical_list: D011760:Pyrrolidinones; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D003523:Cycloserine; C001369:1-hydroxy-3-amino-2-pyrrolidone; D005998:Glycine