title: Molecular interactions of cytomegalovirus and the human and simian immunodeficiency viruses.
abstract: In HuT 78 cells chronically infected with SIV, super-infection with rhesus cytomegalovirus (rhCMV) stimulated an increase in SIV replication. Utilizing transient expression assays with the SIV long terminal repeat (LTR) driving expression of the chloramphenicol acetyltransferase (CAT) reporter gene, the increase in SIV replication, by coinfection with CMV, was due to transactivation of the SIV LTR by the immediate early gene products (IE) of rhesus CMV. Similarly, IE of human CMV stimulated expression from both the SIV and HIV LTRs.
authors.affiliation: Department of Medical Pathology, University of California, Davis.
authors.forename: P A
authors.initials: PA
authors.lastname: Barry
authors.forename: E
authors.initials: E
authors.lastname: Pratt-Lowe
authors.forename: R E
authors.initials: RE
authors.lastname: Unger
authors.forename: M
authors.initials: M
authors.lastname: Marthas
authors.forename: D J
authors.initials: DJ
authors.lastname: Alcendor
authors.forename: P A
authors.initials: PA
authors.lastname: Luciw
mesh_terms: D000818:Animals; D002460:Cell Line; D003587:Cytomegalovirus / Q000235:genetics* / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D006678:HIV / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008253:Macaca mulatta; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000502:physiology; D015163:Superinfection; D015533:Transcriptional Activation; D014779:Virus Replication / Q000235:genetics
chemical_list: D012367:RNA, Viral