title: Facilitation of GABA-induced depression with PCP and sigma receptor agonists was mediated through catecholaminergic pathways.
abstract: The purpose of this experiment was to investigate the interactions of norepinephrine with PCP (phencyclidine) and sigma receptor agonists--modulated GABA (gamma aminobutyric acid) response in the cerebellum. Drugs were directly applied to a single cerebellar Purkinje neuron of urethane-anesthesitized rat through a multibarrel pipette. (+)PCMP [1-(-1-phenylcyclohexyl)-3-methyl piperidine], a PCP receptor agonist, and dexoxadrol, a sigma receptor agonist, significantly enhanced GABA induced inhibition. In norepinephrine-depleted animals, however, both (+)PCMP and dexoxadrol did not modulate GABA's effect. In conclusion, our findings indicated that the PCP/sigma-induced facilitation of GABA reactions were mediated through noradrenergic system in the cerebellum.
authors.affiliation: Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: M C
authors.initials: MC
authors.lastname: Kao
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D004148:Dioxolanes / Q000494:pharmacology; D004594:Electrophysiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017480:Receptors, sigma; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D004148:Dioxolanes; D010880:Piperidines; D011957:Receptors, Opioid; D017480:Receptors, sigma; C036590:1-(1-phenylcyclohexyl)-3-methylpiperidine; C005840:dioxadrol; D005680:gamma-Aminobutyric Acid; D010622:Phencyclidine; C579650:dexoxadrol; D009638:Norepinephrine