Fission yeast cdc25 is a cell-cycle regulated protein.
Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2/M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2.
Ducommun
B
B
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Draetta
G
G
Young
P
P
Beach
D
D
D015153:Blotting, Western; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics*; D015870:Gene Expression; D005800:Genes, Fungal; D009584:Nitrogen; D010957:Plasmids; D011401:Promoter Regions, Genetic; D012568:Schizosaccharomyces / Q000235:genetics*; D020666:ras-GRF1
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D020666:ras-GRF1; D009584:Nitrogen