[Effects of high and low doses of vitamins A and E on the excitability of frog cardiomyocytes].
The effects of complex vitamins A and E on electrophysiological characteristics was investigated on frog cardiomyocytes. Large doses of vitamins A and E decreased the steepness of the action potential (AP) front, decreased the spike amplitude, shortened the plateau, decreased the steepness in the last phase of AP-repolarization, and decreased the rest potential level but considerably increased overshoot. The Ap-duration decreased noticeably. Small doses of vitamins decreased the spike amplitude, shortened the plateau, decreased the Ap-duration. We assume that complex of vitamins A and E can affect the cardiomyocyte membrane transport function, mainly due to the suppression of the slow membrane channels. The AP-front increase is less steep under the influence of vitamins. It is shown that the 0-phase depolarization speed decreases due to the inhibition of sodium channels.
Satybaldina
N K
NK
Frolov
V A
VA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000166:cytology*; D011896:Rana temporaria; D015222:Sodium Channels / Q000187:drug effects; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D015222:Sodium Channels; D014801:Vitamin A; D014810:Vitamin E
Vliianie vysokikh i nizkikh doz vitaminov A i E na vozbudimost' kardiomiotsitov liagushki.