Recombinant fowlpox viruses inducing protective immunity against Newcastle disease and fowlpox viruses.
The haemagglutinin-neuraminidase gene of Newcastle disease virus was inserted into a non-essential region of the fowlpox virus genome and expressed under control of the vaccinia virus 7.5 kDa polypeptide gene promoter. Immunization with the recombinant fowlpox virus elicited protective immunity in chickens against both virulent Newcastle disease and fowlpox virus infection.
Ogawa
R
R
Biological Science Institute, R&D Center, Nippon Zeon Co. Ltd, Kawasaki, Japan.
Yanagida
N
N
Saeki
S
S
Saito
S
S
Ohkawa
S
S
Gotoh
H
H
Kodama
K
K
Kamogawa
K
K
Sawaguchi
K
K
Iritani
Y
Y
D000818:Animals; D001483:Base Sequence; D002645:Chickens; D005586:Fowlpox / Q000517:prevention & control; D005587:Fowlpox virus / Q000235:genetics* / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006389:Hemagglutinins, Viral / Q000235:genetics; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics; D009521:Newcastle Disease / Q000276:immunology / Q000517:prevention & control; D009522:Newcastle disease virus / Q000235:genetics* / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology*
D006389:Hemagglutinins, Viral; D014614:Vaccines, Synthetic; D009439:Neuraminidase