title: Phosphorylation of an inositol phosphate-stimulated protein phosphatase by protein kinase C.
abstract: It is shown that the catalytic subunit of an inositol phosphate-stimulated protein phosphatase (a member of the type-1 protein phosphatase family) purified from bovine brain membranes is phosphorylated in vitro by protein kinase C, but not by protein kinase A or by Ca2+/calmodulin-dependent protein kinase II. The phosphorylation of the protein phosphatase by protein kinase C induces an increased sensitivity to stimulation by Ins (1,4,5)P3, Ins(1,3,4,5,6)P5 and heparin.
authors.affiliation: Centre de Neurochimie CNRS, Strasbourg, France.
authors.forename: J
authors.initials: J
authors.lastname: Zwiller
authors.forename: M O
authors.initials: MO
authors.lastname: Revel
authors.forename: A L
authors.initials: AL
authors.lastname: Boynton
authors.forename: R
authors.initials: R
authors.lastname: Honkanen
authors.forename: G
authors.initials: G
authors.lastname: Vincendon
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D002462:Cell Membrane / Q000201:enzymology; D006493:Heparin / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology; D007295:Inositol Phosphates / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology; D010718:Phosphatidylserines / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D007295:Inositol Phosphates; D010718:Phosphatidylserines; C013571:inositol pentaphosphate; D015544:Inositol 1,4,5-Trisphosphate; D006493:Heparin; D011494:Protein Kinases; D011493:Protein Kinase C; D010749:Phosphoprotein Phosphatases; D013755:Tetradecanoylphorbol Acetate