[The effect of caffeine on the cardiac diastole and systole in rats and guinea pigs].
The pump function and left ventricular (LV) pressure of isolated rat or guinea pig hearts were measured during caffeine infusion into the perfusate at increasing concentrations (0.1-0.25 mM for rats and 1-5 mM for guinea pigs). Caffeine in low doses produced an increase in heart rate and in higher doses it caused a decrease in cardiac output, systolic pressure and +dP/dt. A delayed relaxation and a rise in minimal diastolic pressure followed by a fall in LV filling pressure area, occurred concomitantly. The alterations of diastolic indices were more obvious than the changes in systolic ones. An elevation of LV diastolic stiffness followed by a decrease in LV filling was associated with a facilitation of LV ejection at equal LV filling pressure area or +dP/dt.
Kapel'ko
V I
VI
Novikova
N A
NA
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002306:Cardiac Volume / Q000187:drug effects / Q000502:physiology; D003971:Diastole / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013045:Species Specificity; D013599:Systole / Q000187:drug effects* / Q000502:physiology
D002110:Caffeine
Vliianie kofeina na diastolu i sistolu serdets krys i morskikh svinok.