[The diagnostic information value of determining the cytochemical properties of the neutrophils from the blood and synovial fluid of patients with rheumatoid arthritis and osteoarthrosis deformans].
Alkaline phosphatase (AP), acid phosphatase and myeloperoxidase (MP) activity and the level of cation protein (CP) in blood and synovial fluid (SF) neutrophils were studied and compared in 54 patients with rheumatoid arthritis (RA) and in 22 patients suffering from primary osteoarthrosis deformans (OAD) combined with reactive synovitis. As compared to the patients with OAD, the patients with RA manifested a significant rise of AP, acid phosphatase and MP activity together with a decrease of the level of CP in blood neutrophils. Meanwhile in SF neutrophils from the patients with RA, all the parameters appeared higher than in OAD and were lower that in blood neutrophils in both the groups. As compared to the routine biochemical and cytological tests, the diagnostic information content of the cytochemical parameters of blood neutrophils (AP, acid phosphatase) and SF neutrophils (AP, acid phosphatase, MP) from the patients with RA (against the patients suffering from OAD) was noticeably higher.
Ionov
A Iu
AIu
Fisher
A A
AA
Shubich
M G
MG
D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000201:enzymology; D001798:Blood Proteins / Q000032:analysis; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D010003:Osteoarthritis / Q000175:diagnosis* / Q000201:enzymology; D009195:Peroxidase / Q000032:analysis; D013582:Synovial Fluid / Q000166:cytology / Q000201:enzymology*
D001798:Blood Proteins; D009195:Peroxidase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Diagnosticheskaia informativnost' opredeleniia tsitokhimicheskikh svoĭstv neĭtrofilov krovi i sinovial'noĭ zhidkosti u bol'nykh revmatoidnym artritom i deformiruiushchim osteoartrozom.