title: A reliable method for establishing viral infection in the rabbit by intranasal inoculation.
abstract: Bovine herpesvirus 1 (BHV-1) infection was established in the rabbit by a novel procedure which involved virus being injected through trephine openings on either side of the nose of anaesthetised animals. This method of intranasal inoculation produced more consistent reactions to BHV-1 inoculation, and both humoral and cell-mediated immune responses to the virus were of greater magnitude compared with those following per naris instillation of virus.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
authors.forename: G A
authors.initials: GA
authors.lastname: Brown
authors.forename: H J
authors.initials: HJ
authors.lastname: Field
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006566:Herpesviridae Infections; D007242:Herpesvirus 1, Bovine / Q000472:pathogenicity*; D011817:Rabbits
chemical_list: D000914:Antibodies, Viral