title: Cervical intraepithelial neoplasia III in an adolescent with Bowenoid papulosis.
abstract: Bowenoid papulosis (BP) is a cutaneous condition of the external genitalia seen primarily in young adults. Evidence supports an etiologic role of human papillomavirus (HPV), particularly type 16. HPV-16 is also associated with an increased risk for cervical intraepithelial neoplasia (CIN) and invasive carcinoma. A 17-year-old female, referred to the adolescent dysplasia clinic with a diagnosis of condyloma acuminatum, was presented. She had multiple smooth, shiny, brown 3- to 4-mm papules on the external genitalia. Biopsy confirmed BP. Colposcopic examination of the cervix and biopsy showed CIN III. The patient's sexual partner was examined colposcopically, and no suspicious lesions were seen. The patient underwent laser vaporization of her external genital and cervical lesions. At the time of treatment, some of the initial BP lesions had spontaneously regressed. This case highlights the need to evaluate females with BP for possible CIN, to examine sexual partners, and to use ablative therapy, as there is the potential of malignant progression in BP.
authors.affiliation: Department of Pediatrics, William Beaumont Army Medical Center, El Paso, Texas 79920-5001.
authors.forename: E M
authors.initials: EM
authors.lastname: Stafford
authors.forename: H
authors.initials: H
authors.lastname: Greenberg
authors.forename: P A
authors.initials: PA
authors.lastname: Miles
mesh_terms: D000293:Adolescent; D001913:Bowen's Disease / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D003218:Condylomata Acuminata / Q000473:pathology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae; D012878:Skin Neoplasms / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*