Fowlpox virus recombinant encoding the measles virus fusion protein: protection of mice against fatal measles encephalitis.
A recombinant Fowlpox virus engineered to encode the measles virus fusion protein was shown to protect mice against a challenge measles infection. A vaccine dose of about 10(6) p.f.u. was needed to protect nearly 100% of the animals. Mice failed to develop a significant level of antibodies directed against measles virus suggesting that other components of the immune system may be involved.
Wild
F
F
Immuno-Virologie Moléculaire et Cellulaire CNRS, Université Claude Bernard Lyon I, France.
Giraudon
P
P
Spehner
D
D
Drillien
R
R
Lecocq
J P
JP
D000818:Animals; D005260:Female; D005587:Fowlpox virus / Q000235:genetics* / Q000276:immunology; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D008459:Measles virus / Q000235:genetics* / Q000276:immunology; D051379:Mice; D011995:Recombination, Genetic; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000276:immunology
D014760:Viral Fusion Proteins