title: Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.
abstract: Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
authors.forename: N
authors.initials: N
authors.lastname: Dyson
authors.forename: R
authors.initials: R
authors.lastname: Bernards
authors.forename: S H
authors.initials: SH
authors.lastname: Friend
authors.forename: L R
authors.initials: LR
authors.lastname: Gooding
authors.forename: J A
authors.initials: JA
authors.lastname: Hassell
authors.forename: E O
authors.initials: EO
authors.lastname: Major
authors.forename: J M
authors.initials: JM
authors.lastname: Pipas
authors.forename: T
authors.initials: T
authors.lastname: Vandyke
authors.forename: E
authors.initials: E
authors.lastname: Harlow
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000032:analysis / Q000235:genetics; D000882:Haplorhini; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D010215:Papio; D010750:Phosphoproteins / Q000032:analysis / Q000378:metabolism; D011120:Polyomavirus / Q000235:genetics / Q000276:immunology*; D011485:Protein Binding; D016160:Retinoblastoma Protein; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000952:Antigens, Polyomavirus Transforming; D009687:Nuclear Proteins; D010750:Phosphoproteins; D016160:Retinoblastoma Protein