[Effects of clinical death and pre-administered inderal on adrenoreactivity of the heart in post-resuscitation period].
Acute lethal blood loss followed by resuscitation was found to decrease noradrenaline and increase epinephrine levels in heart muscle in experiments on mongrel male rats which significantly increase heart beta-adreno-receptors sensitivity to exogenous noradrenaline. Preliminary inderal injection prevents excessive heart beta-adreno-receptors stimulation by catecholamines, considerably reduces post-resuscitation rhythmic disturbances and prevents ventricular fibrillation which significantly decreases early post-resuscitation lethality.
Dolgikh
V T
VT
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D004837:Epinephrine / Q000032:analysis; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D009638:Norepinephrine / Q000032:analysis / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012151:Resuscitation; D014693:Ventricular Fibrillation / Q000517:prevention & control
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine
Vliianie klinicheskoĭ smerti i predvaritel'no vvodimogo inderala na adrogenoreaktivnost' serdtsa krys v postreanimatsionnom periode.