[A neuropharmacological analysis of ketamine analgesia during the central stimulation of alpha 2-adrenoreceptors].
The experiments on albino rats showed that clofeline administered in a subanalgesic dose significantly potentiates the analgesic effect of ketamine at the segmental and suprasegmental levels mainly through mu-opiate and partially through beta 2-adrenergic chains. The initiating role in potentiation belongs to the activation of alpha 2-adrenoreceptors. The analgesic effect of ketamine at the segmental and suprasegmental levels is implemented through alpha 2-adrenergic apparatus and at the suprasegmental level is additionally of naloxone-depended character. The clinical trials showed that a preliminary administration of clofeline during postoperative analgesia with ketamine potentiates and prolongs the analgesic action of the latter.
Tarakanov
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AV
D000698:Analgesia; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004357:Drug Synergism; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D011182:Postoperative Care; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D007649:Ketamine; D003000:Clonidine
Neĭrofarmakologicheskiĭ analiz ketaminovoĭ anal'gezii pri tsentral'noĭ stimuliatsii al'fa 2-adrenoretseptorov.