title: Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy.
abstract: Records of 15 patients with stage III and IV malignant mixed mesodermal tumors of the ovary treated between 1977 and 1988 were reviewed. All patients had primary surgery; 13 were given postoperative chemotherapy including doxorubicin and cis-platinum. Median survival for patients receiving chemotherapy is 16 months; 62% were alive at 12 months and 31% at 24 months. Progression-free responses were seen in 85% of treated patients and 55% of these recurred. All recurrences involved the pelvis and were predominantly mesenchymal. Serum CA-125 values accurately reflected tumor presence in 82% of tested patients. Cytoreductive surgery followed by treatment including doxorubicin- and cis-platinum-based chemotherapy is effective in treatment of disseminated ovarian mixed mesodermal tumors, but additional components must be added to achieve durable responses and consistently prolonged survivals.
authors.affiliation: Department of Obstetrics, Gynecology, Mount Sinai Medical Center, New York, New York 10029.
authors.forename: S C
authors.initials: SC
authors.lastname: Plaxe
authors.forename: P R
authors.initials: PR
authors.lastname: Dottino
authors.forename: H M
authors.initials: HM
authors.lastname: Goodman
authors.forename: L
authors.initials: L
authors.lastname: Deligdisch
authors.forename: M
authors.initials: M
authors.lastname: Idelson
authors.forename: C J
authors.initials: CJ
authors.lastname: Cohen
mesh_terms: D000368:Aged; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D013534:Survival
chemical_list: D004317:Doxorubicin; D002945:Cisplatin