title: 99Tcm (v) DMSA and 67Ga-citrate imaging in patients with head and neck squamous carcinoma: a clinical and scintigraphic study.
abstract: Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. This study was undertaken to compare planar scintigraphy in patients with head and neck SCC using 99Tcm (v) DMSA and the established tumour imaging agent gallium-67 citrate (67Ga). Seventeen patients were studied of whom 16 had a head and neck malignancy. Clinical examination was more sensitive and accurate than 67Ga scintigraphy, which in turn was more sensitive and accurate than 99Tcm (v) DMSA in detecting patients with cancer, patients with primary tumours and patients with metastatic neck carcinoma. Neither 67Ga or 99Tcm (v) DMSA planar scintigraphy has any role to play in the routine evaluation at presentation of patients with head and neck SCC.
authors.affiliation: Department of Otolaryngology, Guy's Hospital, London, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Watkinson
authors.forename: C R
authors.initials: CR
authors.lastname: Lazarus
authors.forename: M N
authors.initials: MN
authors.lastname: Maisey
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D004113:Succimer; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D015609:Organotechnetium Compounds; D013438:Sulfhydryl Compounds; D019343:Citric Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer