title: Influence of hydrazinophthalazines on the activity of collagenase in murine fibroblast culture.
abstract: Murine fibroblasts cultured in vitro were treated with hydrazinophthalazine drugs inducing the lupus erythematosus-like syndrome. Collagenase enzyme activity in the growth medium was found to be increased 3-fold by hydralazine and 1.8-fold by binazine, as compared to the control cultures. The enhanced level of collagenolytic activity points to the metabolic changes in the connective tissue in response to hydrazinophtalazines.
authors.affiliation: Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Weglarz
authors.forename: M
authors.initials: M
authors.lastname: Drózdz
authors.forename: M
authors.initials: M
authors.lastname: Wardas
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology; D006834:Hydrazines / Q000009:adverse effects / Q000494:pharmacology*; D051379:Mice; D003012:Microbial Collagenase / Q000096:biosynthesis / Q000378:metabolism*; D014032:Todralazine / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D006834:Hydrazines; C029424:hydrazine; D003012:Microbial Collagenase; D014032:Todralazine