Repair inhibition in tumours irradiated with fast protons and negative pions.
Solid Ehrlich mouse tumours were irradiated in the 80 MeV proton beam of the Paul-Scherrer-Institute. The tumour volume was measured as a function of time after irradiation and two experimental endpoints were determined: local tumour control and minimal tumour volume after irradiation. The application of 2-deoxy-D-glucose (2-DG; 2 mg/kg) increased the radiation effect of protons by a factor of 1.4. The same tumour system was used with negative pions. Human tumours are usually irradiated with a mixed radiation produced by the "spot-scan-technique". This radiation quality was simulated in the mouse experiment by two successive irradiations with a spot of densely ionizing peak pions and a spot of sparsely ionizing plateau pions. Application of 2-DG raised the radiation effect due to the sparsely ionizing component again by a factor of 1.4. This indicates that clinical results in radiotherapy might be improved by application of 2-DG during the treatment.
Jüling-Pohlit
L
L
Institute for Biophysics, University of Frankfurt, FRG.
Pohlit
W
W
Blattmann
H
H
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000532:radiotherapy*; D003837:Deoxy Sugars / Q000627:therapeutic use*; D003847:Deoxyglucose / Q000627:therapeutic use*; D004601:Elementary Particles / Q000627:therapeutic use*; D006801:Humans; D008651:Mesons / Q000627:therapeutic use*; D051379:Mice; D011522:Protons; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012062:Relative Biological Effectiveness; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy
D003837:Deoxy Sugars; D011522:Protons; D003847:Deoxyglucose