Mechanisms of action of nonsteroidal anti-inflammatory drugs and therapeutic considerations.
Nonsteroidal anti-inflammatory drugs (NSAIDs) have anti-inflammatory, analgesic, and antipyretic properties. Although most NSAIDs inhibit prostaglandin synthesis, these agents also have important pharmacologic actions unrelated to their effects on prostaglandins. This review examines the evidence for diverse mechanisms of action of NSAIDs and their use in sports injuries.
Abramson
S B
SB
Department of Rheumatology, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001265:Athletic Injuries / Q000188:drug therapy; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists; D011453:Prostaglandins