Control by thyrotropin of the production by thyroid cells of an inositol phosphate-glycan.
The increased turnover of phosphatidylinositol promoted by thyrotropin (TSH) in pig thyroid tissue does not seem to be caused by an increased production of inositol tris-phosphate. We have explored another possibility, the synthesis of an inositol phosphate-glycan (IP-gly). Our results show that thyroid cells in culture produced this substance from a precursor phosphatidylinositol-glycan (Gly-PI). The obtained IP-gly seemed, by its analytical and biological properties, to be identical, or similar, to the previously described insulin mediator.
Martiny
L
L
Biochimie, Faculté des Sciences, Reims, France.
Antonicelli
F
F
Thuilliez
B
B
Lambert
B
B
Jacquemin
C
C
Haye
B
B
D000818:Animals; D002478:Cells, Cultured; D005576:Colforsin / Q000494:pharmacology; D007295:Inositol Phosphates / Q000096:biosynthesis* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011134:Polysaccharides / Q000096:biosynthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015290:Second Messenger Systems / Q000187:drug effects*; D013552:Swine; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000494:pharmacology*
D007295:Inositol Phosphates; D007328:Insulin; D008563:Membrane Lipids; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D010743:Phospholipids; D011134:Polysaccharides; C028039:inositol phosphate glycan; D005576:Colforsin; D013972:Thyrotropin