Vasoactive intestinal peptide regulation of neuroblast mitosis and survival: role of cAMP.
The role of adenosine 3':5'-cyclic monophosphate (cAMP) in the regulation of neuroblast mitosis and survival by vasoactive intestinal peptide (VIP) was examined. VIP increased the cAMP content of cultured rat sympathetic neuroblasts. Further, cAMP stimulated DNA synthesis and survival in neuroblast cultures, replicating the effects of VIP. Thus, the VIP-cAMP signaling pathway may be involved in the regulation of neuronal development.
Pincus
D W
DW
Department of Neurology, Cornell University Medical College, New York, NY 10021.
DiCicco-Bloom
E M
EM
Black
I B
IB
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D003994:Bucladesine; D000242:Cyclic AMP