Depression of alveolar macrophage hydrogen peroxide and superoxide anion release by mineral dusts: correlation with antimony, lead, and arsenic contents.
Activated rabbit alveolar macrophages were incubated with airborne dusts from four West German sites (1 to 200 micrograms/10(6) cells) and waste incinerator fly ash fractions (50 to 500 micrograms/10(6) cells). Quartz dust DQ 12 (5 to 200 micrograms/10(6) cells) and Fe2O3 (0.05 to 50 micrograms/10(6) cells) were used as control dusts. The zymosan-stimulated hydrogen peroxide and superoxide anion release of the macrophages were not affected significantly by Fe2O3. All other investigated dusts decreased the two cell functions which were correlated negatively with surfaces, particle numbers, and antimony, lead, and arsenic contents of the dusts. The influence of heavy metal antagonisms and dust surfaces on dust toxicity against alveolar macrophages is discussed.
Gulyas
H
H
Department of Biochemistry, University of Hamburg, Federal Republic of Germany.
Labedzka
M
M
Gercken
G
G
D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000818:Animals; D000965:Antimony / Q000032:analysis / Q000633:toxicity*; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D002244:Carbon / Q000032:analysis / Q000633:toxicity; D002478:Cells, Cultured; D060729:Coal Ash; D004391:Dust / Q000032:analysis*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007854:Lead / Q000032:analysis / Q000633:toxicity*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008903:Minerals / Q000032:analysis / Q000633:toxicity*; D052638:Particulate Matter; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D013481:Superoxides / Q000378:metabolism*
D000393:Air Pollutants; D060729:Coal Ash; D004391:Dust; D008903:Minerals; D052638:Particulate Matter; D013481:Superoxides; D007854:Lead; D002244:Carbon; D000965:Antimony; D006861:Hydrogen Peroxide; D001151:Arsenic