Drug-induced granulocytopenia with natural killer lymphocytosis after renal transplantation.
Following renal transplantation, a patient developed life-threatening granulocytopenia secondary to a specific combination of drugs which are commonly utilized in this setting. Coincident with the depression of granulocytes, an expansion of natural killer cells was seen, which may have been a consequence of immunosuppressive therapy required for allograft retention. Infection with cytomegalovirus may have contributed to both phenomena.
Holcombe
R F
RF
Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
D000328:Adult; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced*; D001379:Azathioprine / Q000009:adverse effects*; D002927:Cimetidine / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications; D004359:Drug Therapy, Combination; D006801:Humans; D016030:Kidney Transplantation; D007694:Killer Cells, Natural / Q000187:drug effects*; D008218:Lymphocytosis / Q000097:blood / Q000139:chemically induced*; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D002927:Cimetidine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001379:Azathioprine