[The effect of serotonin on the hypothalamic structures that participate in the regulation of the hypophyseal-adrenal cortex system].
The activation of the 11-hydroxycorticosteroids secretion by 5-hydroxytryptophan was confirmed in intact rats as well as in those with isolated mediobasal hypothalamus. Deafferentation of the medial basal hypothalamus did not prevent an increase of corticoliberin and vasopressin content in the external median eminence after adrenalectomy and led to an opposite response after 5-hydroxytryptophan injection in these rats. The activation of the vasopressinergic cells and increase of portal vessels' lumen occurred under the 5-hydroxytryptophan effect, particularly in rats subjected to deafferentation combined with adrenalectomy.
Maslova
L N
LN
Chernigovskaia
E V
EV
Belen'kiĭ
M A
MA
Danilova
O A
OA
Naumenko
E V
EV
Polenov
A L
AL
D015062:11-Hydroxycorticosteroids / Q000097:blood; D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003714:Denervation; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D014667:Vasopressins / Q000378:metabolism
D015062:11-Hydroxycorticosteroids; D014667:Vasopressins; D012701:Serotonin; D003346:Corticotropin-Releasing Hormone; D006916:5-Hydroxytryptophan
Vliianie serotonina na gipotalamicheskie struktury, uchastvuiushchie v reguliatsii gipofizarno-adrenokortikal'noĭ sistemy.