[The effect of allapinine on the sodium currents of isolated trigeminal ganglion neurons and cardiomyocytes of rats].
Block of sodium currents by allapinine (diterpene alkaloid with strong antiarrhythmic properties) was investigated in isolated, voltage-clamped trigeminal neurons of a rat and single ventricular myocytes of a neonatal rat. Allapinine (in micromolar concentrations) produced a 70-90% decrease of the sodium current amplitude without any changes in voltage-dependent properties of INa in both neurons and cardiomyocytes. Allapinine also blocked the aconitine-modified sodium current. An increase of depolarization frequencies (0.5 to 5.0 Hz) produced no additional block of sodium currents in allapinine-bathed neurons and ventricular myocytes.
Valeev
A E
AE
Verkhratskiĭ
A N
AN
Dzhakhangirov
F N
FN
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D009206:Myocardium / Q000166:cytology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011898:Ranidae; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology; D012668:Trigeminal Ganglion / Q000187:drug effects* / Q000502:physiology
D000889:Anti-Arrhythmia Agents; D015222:Sodium Channels; C051402:allapinin; D000157:Aconitine
Vliianie allapinina na natrievye toki izolirovannykh neĭronov trigeminal'nogo gangliia i kardiomiotsitov krys.