title: [Selection of a herpes simplex mutant virus of weak pathogenicity, sensitive to acyclovir and not susceptible to reactivation in vivo].
abstract: From a KOS herpes simplex virus strain prepared in VERO cells we have been able to obtain after several exposures to increasing concentrations of trifluorothymidine, four resistant mutants. Among these strains, 31 T mutant was a TK-altered strain of low pathogenicity, sensible to acyclovir and did not induce recurrences. These properties might allow the use of such a strain as a living attenuated antiherpetic vaccine.
authors.affiliation: Laboratoires d'Ophtalmologie et de Virologie, Centre Hospitalier Universitaire de Brest.
authors.forename: J
authors.initials: J
authors.lastname: Colin
authors.forename: B
authors.initials: B
authors.lastname: Jouppe
authors.forename: A
authors.initials: A
authors.lastname: Robinet
authors.forename: J M
authors.initials: JM
authors.lastname: Huraux
authors.forename: C
authors.initials: C
authors.lastname: Chastel
mesh_terms: D000212:Acyclovir / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*
chemical_list: D000212:Acyclovir
vernacular_title: Sélection d'un mutant d'herpès simplex virus de faible pathogénicité, sensible à l'acyclovir et non réactivable in vivo.