title: Association between plasma levels of tissue plasminogen activator and postoperative deep vein thrombosis--influence of prophylaxis with a low molecular weight heparin. The Venous Thrombosis Group.
abstract: In a prospective, randomized controlled study, tissue plasminogen activator (t-PA) and tissue plasminogen activator antigen (t-PA:ag) were measured pre- and postoperatively in 40 consecutive patients undergoing total hip replacement. Patients received either a subcutaneous injection of low molecular weight heparin or placebo once daily. Deep vein thrombosis was diagnosed by bilateral phlebography. Patients who developed postoperative thromboembolic complications had significantly lower preoperative t-PA activity levels than patients who did not develop such complications. No difference was observed between the two groups with respect to t-PA:ag. Thromboprophylaxis with low molecular weight heparin did not cause any significant changes in t-PA activity and t-PA:ag. This study in high risk patients indicates that impaired fibrinolysis may be associated with development of thromboembolic complications after operation.
authors.affiliation: Dept. of Orthopedics, Aalborg Hospital, Denmark.
authors.forename: J V
authors.initials: JV
authors.lastname: Sørensen
authors.forename: L C
authors.initials: LC
authors.lastname: Borris
authors.forename: M R
authors.initials: MR
authors.lastname: Lassen
authors.forename: H M
authors.initials: HM
authors.lastname: Christiansen
authors.forename: P
authors.initials: P
authors.lastname: Schøtt
authors.forename: A D
authors.initials: AD
authors.lastname: Olsen
authors.forename: H S
authors.initials: HS
authors.lastname: Neerstrand
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000517:prevention & control; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013924:Thrombophlebitis / Q000097:blood* / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D010959:Tissue Plasminogen Activator