D-penicillamine induced pemphigus treated with methylprednisolone pulse therapy.
A patient with severe rheumatoid arthritis received d-penicillamine treatment for 16 months. She developed mild pruritus 6 months after d-penicillamine initiation, and severe pemphigus 10 months after d-penicillamine was changed to azathioprine. Subsequent methylprednisolone pulse therapy resulted in a transient clinical remission of pemphigus. A literature review of d-penicillamine induced pemphigus and high dose methylprednisolone pulse therapy is presented.
Wouters
E A
EA
Immunologie en Rheumatologie, Universitair Ziekenhuis Antwerpen, Edegem.
De Clerck
L S
LS
Francx
L
L
Stevens
W J
WJ
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D010392:Pemphigus / Q000139:chemically induced* / Q000188:drug therapy; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D010396:Penicillamine; D008775:Methylprednisolone