title: Design of a 13C (1H) RF probe for monitoring the in vivo metabolism of [1-13C]glucose in primate brain.
abstract: The design of an RF probe suitable for obtaining proton-decoupled 13C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of 13C and the other to the resonant frequency of 1H, were used to monitor the in vivo metabolism of [1-13C]glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of 13C-enriched glutamate and glutamine 30 to 40 min after a bolus injection of [1-13C]glucose.
authors.affiliation: Intermagnetics General Corporation, Guilderland, New York 12084.
authors.forename: B E
authors.initials: BE
authors.lastname: Hammer
authors.forename: W
authors.initials: W
authors.lastname: Sacks
authors.forename: R E
authors.initials: RE
authors.lastname: Bigler
authors.forename: M J
authors.initials: MJ
authors.lastname: Hennessy
authors.forename: S
authors.initials: S
authors.lastname: Sacks
authors.forename: A
authors.initials: A
authors.lastname: Fleischer
authors.forename: P B
authors.initials: PB
authors.lastname: Zanzonico
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D005947:Glucose / Q000378:metabolism*; D006859:Hydrogen; D008253:Macaca mulatta; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011522:Protons
chemical_list: D002247:Carbon Isotopes; D011522:Protons; D006859:Hydrogen; D005947:Glucose