title: Treatment of experimental Escherichia coli pyelonephritis in rat by ciprofloxacin in comparison with tobramycin.
abstract: The ciprofloxacin efficacy was compared to that of tobramycin in an Escherichia coli pyelonephritis model in rat. Treatments started 48 h after ligation of the left ureter and inoculation of the bladder and continued for 5 days. Ciprofloxacin (2.5 mg/kg/d and 10 mg/kg/d) was administered intravenously either in a single daily dose or in 2 divided doses at 12 h intervals. Tobramycin (2.5 mg/kg/d and 10 mg/kg/d) was administered by the intramuscular route, in a single daily dose. Ciprofloxacin 10 mg/kg/d was as efficacious as tobramycin irrespective of dosage schedule. Ciprofloxacin 2.5 mg/kg/d was more effective when given twice a day than once.
authors.affiliation: Service des Maladies Infectieuses, CHU de Rouen, France.
authors.forename: F
authors.initials: F
authors.lastname: Lecomte
authors.forename: C
authors.initials: C
authors.lastname: Thauvin-Eliopoulos
authors.forename: I
authors.initials: I
authors.lastname: Le Boete
authors.forename: G
authors.initials: G
authors.lastname: Grise
authors.forename: J F
authors.initials: JF
authors.lastname: Lemeland
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004927:Escherichia coli Infections / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D011704:Pyelonephritis / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D002939:Ciprofloxacin; D014031:Tobramycin