Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology.
The action of fluoride ions on G proteins as well as on various ATPases and phosphatases, is related to their complexation with traces of aluminium or beryllium. These fluorometallic complexes act as analogs of phosphate: they bind with high affinity, but reversibly, in phosphate sites or, concomitantly with nucleoside-diphosphate, in nucleoside-triphosphate sites. The beryllofluoride complexes are strictly tetrahedral; they cannot take on the pentavalent conformation adopted by phosphate in transition states hence they interfere with phospho-transfer reaction mechanisms.
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Institut de Pharmacologie Moléculaire et Cellulaire du CNRS, Valbonne, France.
D000535:Aluminum / Q000494:pharmacology*; D017607:Aluminum Compounds; D001608:Beryllium / Q000494:pharmacology*; D001665:Binding Sites; D004798:Enzymes / Q000378:metabolism; D005459:Fluorides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008956:Models, Chemical; D010710:Phosphates / Q000494:pharmacology
D017607:Aluminum Compounds; D004798:Enzymes; D010710:Phosphates; C035982:beryllium fluoride; D000535:Aluminum; D001608:Beryllium; D005459:Fluorides; C032311:aluminum fluoride