Serum IgG antibody to herpes viruses in schizophrenia.
Immunoglobulin measurements have provided indirect evidence to suggest that viruses may play an etiologic role in schizophrenia. The authors review the conflicting studies and report their own measurements of serum antibody absorbance to five viral antigens using an ELISA technique in 38 schizophrenic patients and 22 matched controls. For herpes simplex virus, 12 subjects (32%) had antibody levels more than 2 SD above the control mean.
Pelonero
A L
AL
Dept. of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0710.
Pandurangi
A K
AK
Calabrese
V P
VP
D000328:Adult; D000956:Antigens, Viral / Q000276:immunology; D001925:Brain Damage, Chronic / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D019965:Neurocognitive Disorders / Q000276:immunology*; D012559:Schizophrenia / Q000276:immunology*
D000956:Antigens, Viral; D007074:Immunoglobulin G