[The effect of bombesin and its analogs on the secretion of gastric juice and its content of pepsin and hydrochloric acid].
I.V. Infusion of bombesine after eating raw meat inhibited for 30-60 min the secretion of gastric juice and hydrochloric acid in dogs. Within 90-120 min of simultaneous infusion of pentagastrin and bombesine, the amount of secreted juice and its acidity decreased and then the secretion of gastric parietal cells increased. Simultaneous infusion of histamine and bombesine increased the response of gastric parietal cells during the whole experiment as compared with the histamine effect alone. Microapplication of bombesine into cerebral structures also decreased the secretory response of the parietal cells.
Barashkova
G M
GM
Klimov
P K
PK
Kuranova
I L
IL
Churkina
S I
SI
Filonova
E B
EB
D000818:Animals; D001839:Bombesin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D008460:Meat; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000378:metabolism; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors
D006632:Histamine; D010434:Pepsin A; D010418:Pentagastrin; D001839:Bombesin
Vliianie bombezina i ego analogov na sekretsiiu zheludochnogo soka i soderzhanie v nem pepsina i khloristovodorodnoĭ kisloty.