title: Critical evaluation of the composition and use of topical fluorides, with emphasis on the role of calcium fluoride in caries inhibition.
abstract: There is evidence that a major part of the fluoride which is retained on teeth during topical application is calcium fluoride or calcium fluoride-like, and that this material is relatively stable in the mouth. This is due to surface adsorption of phosphate (HPO4(2-)) ions onto the calcium fluoride surface. Calcium fluoride releases fluoride during caries challenges due to reduced concentration of HPO4(2-) at acid pH. Normally, the fluoride released from calcium fluoride during caries challenges is subsequently built into hydroxyfluorapatite through dissolution/re-precipitation reactions. It appears likely that the formation of calcium fluoride from topical application agents should be increased and not reduced, as believed in the past. Increased deposition of calcium fluoride can be achieved with increased reaction time between fluoride and enamel, reduced pH of the solution, increased concentration, or pre-treatment with calcium. A reduction in pH of the agents is probably the most practical approach to increase the deposition of calcium fluoride during topical application, and clinical data support this contention. Calcium fluorides with various dissolution rates are formed during different procedures of topical application with fluoride, presumably due to incorporation of phosphate into the calcium fluoride crystals.
authors.affiliation: University of Oslo, Dental Faculty, Department of Pedodontics, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Rølla
authors.forename: E
authors.initials: E
authors.lastname: Saxegaard
mesh_terms: D000818:Animals; D002124:Calcium Fluoride / Q000494:pharmacology*; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans
chemical_list: D005460:Fluorides, Topical; D002124:Calcium Fluoride