title: Vitamin C and cellular immune functions. Protection against hypochlorous acid-mediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation.
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, University of Pretoria, Republic of South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Anderson
authors.forename: M J
authors.initials: MJ
authors.lastname: Smit
authors.forename: G K
authors.initials: GK
authors.lastname: Joone
authors.forename: A M
authors.initials: AM
authors.lastname: Van Staden
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D005986:Glyceraldehyde 3-Phosphate / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D006997:Hypochlorous Acid / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D008934:Mitogens; D013438:Sulfhydryl Compounds; D013481:Superoxides; D005986:Glyceraldehyde 3-Phosphate; D009240:N-Formylmethionine Leucyl-Phenylalanine; D006997:Hypochlorous Acid; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005947:Glucose; D013755:Tetradecanoylphorbol Acetate; D001205:Ascorbic Acid