title: N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism.
abstract: Pharmacological inhibition of cell excitation during focal ischemia was studied in the rat middle cerebral artery occlusion model. The potent and selective N-methyl-D-aspartate antagonist CGS 19755, administered 5 minutes prior to or 5 minutes following permanent middle cerebral artery occlusion, caused a substantial decrease in infarct size, which was associated with reduction of postischemic cerebral glucose hypermetabolism. These data support a role for excitation-induced hypermetabolism in the pathogenesis of infarction following focal cerebrovascular occlusion.
authors.affiliation: Department of Neurology, University of California, San Francisco.
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: K
authors.initials: K
authors.lastname: Shiraishi
mesh_terms: D000818:Animals; D003837:Deoxy Sugars / Q000493:pharmacokinetics*; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D004734:Energy Metabolism; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010875:Pipecolic Acids; D010880:Piperidines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D003837:Deoxy Sugars; D010875:Pipecolic Acids; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C053672:selfotel; D003847:Deoxyglucose