Reactivity of human sera with overlapping synthetic peptides of herpes simplex virus type 1 glycoprotein D.
Thirty eight human sera, seropositive for herpes simplex virus (HSV) and 56 human sera, seronegative for HSV by immunofluorescence and by ELISA, were investigated for reactivity with a series of overlapping synthetic peptides of HSV type 1 glycoprotein D (gD-1). Thirty four out of the 38 human sera positive for HSV reacted with peptides located between residues 300 and 369; the HSV-negative sera reacted with six of the gD-1 peptides, but with none of the peptides within residues 300 to 369.
Geerligs
H J
HJ
Laboratorium voor Medische Microbiologie, Rijksuniversiteit Groningen, The Netherlands.
Feijlbrief
M
M
Bolk
M
M
Bos
C A
CA
Drijfhout
J W
JW
Welling
G W
GW
Welling-Wester
S
S
D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D009500:Neutralization Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D010455:Peptides; D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1