title: Removal of pathogenic human viruses by insoluble pyridinium-type resin.
abstract: Cross-linked poly(N-benzyl-4-vinylpyridinium bromide) (BVP resin) was found to be very efficient in removing pathogenic human viruses from aqueous solution. In batch removal experiments using 50 g/l of BVP resin at 35 degrees C, the level of infectivity in suspensions of enterovirus, herpes simplex virus, poliovirus, and human immunodeficiency virus was reduced 1000-100,000 fold during a 2 h period. Those of coxsackievirus and echovirus were reduced 60-600 fold during 1 h contact. The haemagglutination titres of solutions of human rotavirus, influenza virus, human adenovirus, and Japanese encephalitis virus were reduced 16-256 fold during 30 min of contact. In removal experiments by a continuous flow column method for poliovirus, enterovirus, and coxsackievirus with initial infectivities of less than 10(5)/ml, the infectivity of these viruses was no longer detectable in the effluent solution. For poliovirus, coxsackievirus, and echovirus with initial infectivities higher than 10(6), 99.8-99.9998% of the input viruses was removed as indicated by the reduction of infectivity.
authors.affiliation: Department of Chemistry and Materials Technology, Faculty of Engineering and Design, Kyoto Institute of Technology, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kawabata
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Otake
authors.forename: I
authors.initials: I
authors.lastname: Oishi
authors.forename: Y
authors.initials: Y
authors.lastname: Minekawa
mesh_terms: D000260:Adenoviruses, Human / Q000302:isolation & purification; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification; D004770:Enterovirus / Q000302:isolation & purification; D029822:Enterovirus B, Human / Q000302:isolation & purification; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification; D017955:Poliovirus / Q000302:isolation & purification; D011145:Polyvinyls; D012116:Resins, Plant; D012401:Rotavirus / Q000302:isolation & purification; D018139:Simplexvirus / Q000302:isolation & purification; D012995:Solubility; D014780:Viruses / Q000302:isolation & purification*; D014871:Water Microbiology
chemical_list: D011145:Polyvinyls; D012116:Resins, Plant; C066533:BVP resin