[Direct and indirect effects of mineral water Naftusia and its components on the sodium-potassium pump of the small-intestinal epithelium in rats].
Experiments on rats have shown that intragastric single introduction of mineral water Naftusia to animals in a dose of 1.5% of the body weight of animals induces sodium accumulation in the small intestine epithelium, that is a result of Na(+)-, K(+)-pump inhibition by fatty acids of this water. Naftusia absorption induces appearance of inhibitors of Na(+)-, K(+)-ATPase enzymic system in blood serum of rats. Artificial salt Naftusia analog (ASNA) has induced contrary changes in the water-electrolytic balance and activated Na(+)-, K(+)-ATPase. Blood serum of ASNA-loaded rats acquired ability to activate Na(+)-, K(+)-pump of epitheliocytes in intact rats.
Prokopenko
O N
ON
Kharlamova
O N
ON
Iaremenko
M S
MS
D000818:Animals; D004386:Duodenum / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005227:Fatty Acids / Q000494:pharmacology*; D006294:Health Resorts; D007583:Jejunum / Q000378:metabolism*; D008900:Mineral Waters; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014586:USSR; D014882:Water-Electrolyte Balance
D005227:Fatty Acids; D008900:Mineral Waters; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Priamoe i oposredovannoe deĭstvie mineral'noĭ vody naftusi i ee komponentov na natriĭ-kalievyĭ nasos épiteliia tonkoĭ kishki krysy.