title: Pathobiochemistry of CO poisoning.
abstract: A hypothesis for the pathobiochemical mechanism of CO poisoning, amenable to in vivo testing with optical reflectance spectrophotometry, is presented. It differs from the classical formulation in which loss of cytochrome c oxidase function is attributed entirely to O2 depletion, by including ligation and oxygenation of CO as essential components of the inhibitory process.
authors.affiliation: Department of Biochemistry, Duke University Medical Center, Durham, NC.
authors.forename: L J
authors.initials: LJ
authors.lastname: Young
authors.forename: W S
authors.initials: WS
authors.lastname: Caughey
mesh_terms: D000280:Administration, Inhalation; D002248:Carbon Monoxide / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002249:Carbon Monoxide Poisoning / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D010100:Oxygen / Q000097:blood
chemical_list: D006454:Hemoglobins; D002248:Carbon Monoxide; D003576:Electron Transport Complex IV; D010100:Oxygen