[Evaluation of the prognosis in sarcoidosis: remission as an issue of biological criteria and current cellular activities (ACE and alveolar lymphocytosis)].
The spontaneous evolution of 60 patients suffering from recently diagnosed sarcoidosis was compared with their initial biological profile of "activity". 47% of this unselected group of patients belonged to an inactive group (ACE less than 35 nmol/ml/mn and the percentage of alveolar lymphocytes less than 30%). After a mean period of two years of follow up it turned out that the initial bioprofile of activity had no predicted value, even in the absence of any initial elevation of the markers (3 cases out of 28 grew worse). The repeated controls of criteria of activity did not objectively show any concordant change with the outcome in such cases. It is necessary to point out the unfavourable character of very raised ACE activity greater than 50 nmol/ml/mn (7 deteriorations out of 8 cases). It would appear that a systematic search for these criteria should be deferred principally in type 1 lymph node involvement or pulmonary and mediastinal type IIA, all the more so as in practice they have little influence on therapeutic decisions.
Dietemann-Molard
A
A
Service de Pneumologie, Pavillon Laennec, C.H.R.U., Strasbourg.
De Blay
F
F
Bohner
C
C
Roegel
E
E
Pauli
G
G
D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000145:classification / Q000201:enzymology / Q000473:pathology*; D008218:Lymphocytosis / Q000473:pathology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D011379:Prognosis; D011650:Pulmonary Alveoli / Q000473:pathology*; D012074:Remission Induction; D012507:Sarcoidosis / Q000145:classification / Q000201:enzymology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D007703:Peptidyl-Dipeptidase A
Evaluation du pronostic de la sarcoïdose: remise en question des critères biologiques et cellulaires usuels d'activité. (ECA et lymphocytose alvéolaire).