Lithium counteracts histamine suppression of human T cell mitogenesis.
Human T cell proliferative responses to concanavalin A (conA) were suppressed by approximately 50% by histamine (100 microM). In contrast, LiCl (1 or 3 mM) potentiated T cell responses by about 50%, but 10 mM LiCl had no significant effect on T cell proliferation. Histamine suppression was not significantly affected by the presence of potentiating concentrations of LiCl, whereas 10 mM LiCl completely abrogated histamine suppression.
Hall
T J
TJ
Merrell Dow Research Institute, Strasbourg, France.
Heckel
C
C
Hudspith
B N
BN
Brostoff
J
J
D000328:Adult; D002478:Cells, Cultured; D002712:Chlorides / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*
D002712:Chlorides; D006633:Histamine Antagonists; D003208:Concanavalin A; D008094:Lithium; D018021:Lithium Chloride