[Experimental study of thyroid hormone and bone metabolism in the rat].
Thyroid hormones (T3, T4) stimulate bone turnover. Calcitonin is a potent inhibitor of osteoporostic bone resorption. In patients with thyrotoxicosis, bone mineral content is reduced. We investigated the influence of calcitonin deficiency in thyroidectomized parathyroid-autotransplanted rats with L-thyroxine (T4) supplementation. Thyroidectomy resulted in a reduction of bone volume, bone calcium content and in a decrease in trabecular bone volume. T4-supplementation corrected this loss of bone calcium content but not trabecular bone volume. In thyroidectomized parathyroid-autotransplanted rats matched for T3-levels to intact controls, there was still a reduction in both bone calcium content and trabecular bone volume. We assume this decrease in bone mass in thyroidectomized parathyroid-autotransplanted animals to be caused by the lack of calcitonin.
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D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000172:deficiency*; D005260:Female; D010024:Osteoporosis / Q000209:etiology*; D010280:Parathyroid Glands / Q000637:transplantation; D051381:Rats; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D002116:Calcitonin; D013974:Thyroxine