[The effect of morphine, galanthamine and piracetam on conditioned reflex and brain ATPase activities in the postoperative period].
In the experiments on 300 rats it was established that morphine (5 mg/kg) and galantamine (0.5 mg/kg) exert the normalizing effect on the higher nervous activity in rats during the postoperative period. It is correlated with an increase of Pa,K-ATP activity of the cerebral hemispheric cortex. Administration of piracetam (200 mg/kg) following the previous laparotomy aggravates disturbances of the higher nervous activity occurring after the operative injury and decreases Mg-ATP activity of the cortex of the cerebral hemispheres and hippocampus.
Zlenko
E T
ET
Khomiak
N V
NV
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003214:Conditioning, Classical / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D005702:Galantamine / Q000494:pharmacology*; D006613:Higher Nervous Activity / Q000187:drug effects; D007813:Laparotomy; D008568:Memory / Q000187:drug effects; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D009020:Morphine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D010889:Piracetam / Q000494:pharmacology*; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism
D005702:Galantamine; D009020:Morphine; D000254:Sodium-Potassium-Exchanging ATPase; D010889:Piracetam
Vliianie morfina, galantamina i piratsetama na uslovnoreflektornuiu deiatel'nost' i ATFaznuiu aktivnost' mozga v posleoperatsionnom periode.