title: An intracranial mass lesion in systemic xanthogranulomatosis: case report.
abstract: The authors describe a 42-year-old woman with systemic xanthogranulomatosis and bilateral intraorbital tumors, who subsequently developed multiple lesions of the intracranial dura mater, spinal cord, retroperitoneum, pericardium, and mediastinum. Systemic xanthogranulomatosis is histologically similar to systemic Weber-Christian disease, except for the absence of subcutaneous panniculitis. Immunohistochemical studies suggest that this clinical entity can be differentiated from histiocytosis X, because foamy cells in systemic xanthogranulomatosis demonstrate macrophages but not T-zone histiocyte markers. Differentiation of this disease from other intracranial xanthogranulomas and treatment are discussed.
authors.affiliation: Department of Neurosurgery, Nagoya University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyachi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Hashizume
authors.forename: K
authors.initials: K
authors.lastname: Sugita
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D010201:Panniculitis, Nodular Nonsuppurative / Q000175:diagnosis; D014973:Xanthomatosis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*