title: Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma.
abstract: Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.
authors.affiliation: School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231.
authors.forename: A
authors.initials: A
authors.lastname: de Bustros
authors.forename: R Y
authors.initials: RY
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Compton
authors.forename: T Y
authors.initials: TY
authors.lastname: Tsong
authors.forename: S B
authors.initials: SB
authors.lastname: Baylin
authors.forename: B D
authors.initials: BD
authors.lastname: Nelkin
mesh_terms: D002116:Calcitonin / Q000235:genetics*; D018288:Carcinoma, Small Cell / Q000235:genetics*; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005796:Genes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D010957:Plasmids; D012045:Regulatory Sequences, Nucleic Acid; D013964:Thyroid Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D002116:Calcitonin