title: N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination.
abstract: N-[18F]fluoro-N-alkylsulfonamides were synthesized by the fluorination of secondary sulfonamides with [18F]F2. Radiochemical yields up to 45% (out of a maximum possible yield of 50%) for these reactions have been realized. The N-[18F]fluorosulfonamides rapidly and regiospecifically fluorinate a variety of Grignard reagents and aryllithium under very mild conditions to give 18F-labeled derivatives in good yields.
authors.affiliation: Department of Radiological Sciences, UCLA School of Medicine 90024.
authors.forename: N
authors.initials: N
authors.lastname: Satyamurthy
authors.forename: G T
authors.initials: GT
authors.lastname: Bida
authors.forename: M E
authors.initials: ME
authors.lastname: Phelps
authors.forename: J R
authors.initials: JR
authors.lastname: Barrio
mesh_terms: D005461:Fluorine; D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods; D013449:Sulfonamides / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D013449:Sulfonamides; D005461:Fluorine