Effect of toxic doses of cholecalciferol (vitamin D3) on alkaline phosphatase levels in serum and gingival tissues of rats.
Toxic doses of cholecalciferol (vitamin D3) were injected subcutaneously (25 micrograms/day) into rats for 5 weeks, causing a significant increase of serum alkaline phosphatase (ALP) levels (p less than 0.01). Gingival tissue alkaline phosphatase levels were also elevated (p less than 0.01). On the other hand, a significant difference was detected between serum calcium levels in experimental and control groups (p less than 0.02).
Güven
Y
Y
Department of Biochemistry, Faculty of Dentistry, University of Istanbul, Turkey.
Kasapoğlu
C
C
Yildirim
S
S
Gümrü
O
O
D000469:Alkaline Phosphatase / Q000032:analysis / Q000097:blood*; D000818:Animals; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage / Q000633:toxicity*; D005881:Gingiva / Q000201:enzymology*; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002762:Cholecalciferol; D000469:Alkaline Phosphatase; D002118:Calcium