Role of bradykinin in the regulation of blood pressure and renal blood flow in DOCA-salt hypertensive rats.
We examined the role of bradykinin in the onset and/or the maintenance of blood pressure and renal blood flow in deoxycorticosterone acetate (DOCA)-salt hypertensive rats by using a competitive antagonist of bradykinin [Arg-Pro-Hyp-Gly-Thi-Ser-Dphe-Thi-Arg; Hyp, L-4-hydroxyproline; Thi, beta-(2-theinyl-L-alanine)]. The intravenous injection of the bradykinin antagonist (25, 50 and 100 micrograms) produced an increase in mean arterial pressure in all rats treated with tap water, 1% NaCl and DOCA + 1% NaCl. However, the magnitude of the increase in mean arterial pressure was significantly lower in the DOCA-hypertensive rats than in the two groups of rats drinking tap water and 1% NaCl after 4 and 6 weeks, but there was no significant difference after 2 weeks. The bradykinin antagonist induced a decrease in renal blood flow in all rats. However, the extent of the fall in renal blood flow was reduced in the DOCA-hypertensive rats compared with the control rats drinking tap water. These results suggest that endogenous bradykinin is depressed in the established phase of hypertension in DOCA-hypertensive rats. It is also suggested that endogenous bradykinin may counteract the elevation of vascular resistance in the early stages of this model.
Seino
M
M
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Abe
K
K
Nushiro
N
N
Omata
K
K
Kasai
Y
Y
Tsunoda
K
K
Kanazawa
M
M
Yoshida
K
K
Yoshinaga
K
K
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D003900:Desoxycorticosterone / Q000633:toxicity; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000502:physiology*; D012982:Sodium, Dietary / Q000009:adverse effects
D012982:Sodium, Dietary; D003900:Desoxycorticosterone; D001920:Bradykinin