Role of noradrenaline in behavioral changes after defeat in male and female rats.
We have tested the effect of noradrenaline depletion by clonidine in agonistic behavior of intact male and gonadectomized testosterone-treated female rats. Animals were subjected to the 'resident-intruder' paradigm: in 4 consecutive daily confrontations residents defeated intruders. Clonidine-treated intruder males showed higher levels of aggression than did their saline-injected controls. In contrast, in females, in which defeat was also followed by reduction of aggression, no effect of clonidine treatment was found.
Scholtens
J
J
The Netherlands Institute for Brain Research, Amsterdam.
Roozen
M
M
Mirmiran
M
M
van de Poll
N E
NE
D000374:Aggression / Q000502:physiology*; D000378:Agonistic Behavior / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology; D004291:Dominance-Subordination; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology; D012737:Sex Factors; D012930:Social Dominance; D013739:Testosterone / Q000502:physiology
D011941:Receptors, Adrenergic; D013739:Testosterone; D009638:Norepinephrine