Antibiotic resistance of biomaterial-adherent coagulase-negative and coagulase-positive staphylococci.
Whether or not bacterial populations are massively enclosed in slime, it appears that antibiotic resistance, when compared to suspension organisms, is related to surface adhesion and to the specific material of the substratum. These findings are of significance in the understanding and treatment of biomaterial-localized infections.
Naylor
P T
PT
Section of Orthopedic Surgery, Wake Forest University Medical Center, Winston-Salem, North Carolina 27103.
Myrvik
Q N
QN
Gristina
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A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion; D001672:Biocompatible Materials; D002437:Cefazolin / Q000494:pharmacology; D003030:Coagulase / Q000032:analysis; D017576:Daptomycin; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009254:Nafcillin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003030:Coagulase; D005839:Gentamicins; D010455:Peptides; D009254:Nafcillin; D014640:Vancomycin; D002437:Cefazolin; D017576:Daptomycin