title: Pathology of dual Mycobacterium leprae and simian immunodeficiency virus infection in rhesus monkeys.
abstract: Three rhesus monkeys were experimentally inoculated with sooty-mangabey-derived Mycobacterium leprae and were inadvertently infected with the simian immunodeficiency virus (SIV) as well. They died of an immunodeficiency syndrome, and at autopsy all had lesions caused by M. leprae. One monkey was inoculated twice with M. leprae, initially with an inoculum from a sooty mangabey that was not infected with SIV and, subsequently, with an inoculum from a mangabey that was SIV infected. The monkey did not develop clinical lesions and became strongly lepromin skin test (LST) positive after the first inoculation, but became infected with both agents and LST negative following the second inoculation. These observations suggest that SIV-infected rhesus monkeys have an increased susceptibility to M. leprae infection and, by analogy, imply that HIV-infected human beings may have an increased susceptibility as well.
authors.affiliation: Department of Pathology, Delta Regional Primate Research Center, Tulane University, Covington, Louisiana 70433.
authors.forename: G B
authors.initials: GB
authors.lastname: Baskin
authors.forename: B J
authors.initials: BJ
authors.lastname: Gormus
authors.forename: L N
authors.initials: LN
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Murphey-Corb
authors.forename: G P
authors.initials: GP
authors.lastname: Walsh
authors.forename: W M
authors.initials: WM
authors.lastname: Meyers
mesh_terms: D000818:Animals; D001402:B-Lymphocytes; D007918:Leprosy / Q000150:complications* / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000473:pathology; D008253:Macaca mulatta; D009297:Nasal Mucosa / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D012192:Retroviridae Infections / Q000150:complications* / Q000473:pathology; D015302:Simian Immunodeficiency Virus; D012867:Skin / Q000294:innervation / Q000473:pathology; D012882:Skin Tests