[Preliminary study of the possibility of a viral etiology in cervical cancer].
The authors examined 10 patients with cervical cancer and 5 with condyloma acuminatum. The sera were collected pre- and postoperatively and checked up to the presence of C-reactive protein (CRP), while the method of the complement fixation reaction (CFR) was used to determine the presence of antibodies against herpes adeno and EB virus. The technique of indirect immunofluorescence was used to determine the presence of the mentioned viruses in the maliguant tissue. Eight preoperatively obtained sera contained antibodies against herpes virus, the titre ranging from 1:8 to 1:64. The presence of antibodies against other viruses was insignificant. The antibody titre against herpes virus decreased in 6 postoperatively obtained samples, the highest titre being 1:16. The presence of herpes virus was determined by the immunofluorescence method in 7 out of 10 samples of the maliguant tissue. Adenovirus was found in 1 sample while EB virus was not found. The presence of the investigated viruses was not evidenced in the cases of condylomas either in the tissue or as sera antibodies.
Cokić-Damjanović
J
J
Pasterov zavod, Novi Sad.
D000260:Adenoviruses, Human / Q000302:isolation & purification; D002097:C-Reactive Protein / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000382:microbiology*; D003218:Condylomata Acuminata / Q000737:chemistry / Q000382:microbiology*; D005260:Female; D006564:Herpesviridae / Q000302:isolation & purification; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000382:microbiology*
D002097:C-Reactive Protein
Preliminarna istrazivanja o mogućoj virusnoj etiologiji raka grlića materice.