title: Effects of bicuculline and strychnine on synaptic inputs to edge cells during fictive locomotion.
abstract: Edge cells are mechanoreceptive neurones located in the lateral tracts of the lamprey spinal cord. Phasic activation of these cells by lateral bending can entrain the activity of the locomotor central pattern generator. During fictive locomotion induced by bath-applied NMDLA (N-methyl-D,L-aspartate) or sensory stimulation, edge cells receive synaptic input. In this paper we provide evidence that the tonic inhibition received during sensory-induced fictive locomotion is glycinergic. We also show that during fictive locomotion induced by application of NMDLA to the spinal cord, bicuculline unveils phasic synaptic activity in edge cells. During sensory-evoked fictive locomotion, by contrast, only tonic synaptic activity is apparent in the presence of bicuculline.
authors.affiliation: Department of Physiology, St. George's Hospital Medical School, London, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Alford
authors.forename: T L
authors.initials: TL
authors.lastname: Williams
authors.forename: K A
authors.initials: KA
authors.lastname: Sigvardt
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D005399:Fishes / Q000502:physiology*; D007798:Lampreys / Q000502:physiology*; D008124:Locomotion / Q000187:drug effects*; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology*; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology*
chemical_list: D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D013331:Strychnine; D001640:Bicuculline