title: [Granulocytes and oxidative metabolism: role of monoclonal antibodies in superoxide anion release from neutrophils].
abstract: We studied the effects on the granulocyte oxidative metabolism of some monoclonal antibodies reacting with a membrane surface antigen fundamental for the functions of these cells. The aim of this investigation was to evaluate the role of CD11b/CD18 membrane glycoproteins on superoxide release from granulocytes. The preincubation with MoAbs 60.1, OKM1, 60.3 determined a significant decrease of anion release from granulocytes stimulated by fMLP.
authors.affiliation: Dipartimento di Medicina Interna e Terapia Medica, Università di Pavia.
authors.forename: A
authors.initials: A
authors.lastname: Mazzone
authors.forename: D
authors.initials: D
authors.lastname: Pasotti
authors.forename: A
authors.initials: A
authors.lastname: Fioravanti
authors.forename: E
authors.initials: E
authors.lastname: Uccelli
authors.forename: E
authors.initials: E
authors.lastname: Freddi
authors.forename: L
authors.initials: L
authors.lastname: Nardecchia
authors.forename: M
authors.initials: M
authors.lastname: Bertoldi
mesh_terms: D000911:Antibodies, Monoclonal; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000378:metabolism; D010084:Oxidation-Reduction; D013481:Superoxides / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine
vernacular_title: Integrine granulocitarie e metabolismo ossidativo: ruolo di alcuni anticorpi monoclonali sulla modulazione del rilascio di anione superossido dai neutrofili.