Effects of hypertonic peritoneal dialysis solutions on neutrophil superoxide production.
Superoxide produced by neutrophils plays an important role in the killing of bacterial pathogens. The effects of glucose-containing peritoneal dialysis solutions on superoxide production by canine and human neutrophils were studied. A significant decrement in superoxide generation was noted with the 2.27% and 3.86% glucose solutions. The results suggest that hypertonic peritoneal dialysis solutions curtail neutrophil superoxide generation.
Zhou
F Q
FQ
Department of Medicine, Veterans Administration Hospital, Hines, IL 60141.
Manahan
F J
FJ
Yu
A W
AW
Rahman
M A
MA
Nawab
Z M
ZM
Fisher
K A
KA
Ing
T S
TS
D000818:Animals; D015314:Dialysis Solutions / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
D015314:Dialysis Solutions; D005950:Glucose Solution, Hypertonic; D013481:Superoxides