title: Endothelin receptors in cultured renal epithelial cells.
abstract: We demonstrated the presence of specific binding sites for endothelin in the renal epithelial cell lines. MDCK and LLC-PK1. Endothelin binding induced mobilisation of intracellular calcium, as shown by an increase in 45Ca2+ efflux. This suggests a direct effect of endothelin on renal reabsorption in addition to the effects on the renal vasculature.
authors.affiliation: Institute of Pharmacology, Bayer AG, Wuppertal 1, F.R.G.
authors.forename: D
authors.initials: D
authors.lastname: Neuser
authors.forename: S
authors.initials: S
authors.lastname: Zaiss
authors.forename: J P
authors.initials: JP
authors.lastname: Stasch
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D002417:Cattle; D002460:Cell Line; D004847:Epithelial Cells; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin; D013552:Swine
chemical_list: D002132:Calcium Radioisotopes; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; D002118:Calcium