External ocular inflammatory effects of lipoxygenase enzyme products.
We systematically observed the effects of lipoxygenase enzyme products (5-, 8-, 9-, 12-, and 15-HETE and leukotrienes (LT) C4, D4, and B4) on the external ocular inflammatory process in rabbits. Our results, using 1 and 10 micrograms enzymatic preparations topically applied to the conjunctiva, were consistent with the potent chemotactic activity of 12-HETE and LTB4. Modulation of the inflammatory process can be accomplished better, as a result of our findings, by inhibition of both the lipoxygenase and cyclooxygenase pathways.
Napoli
S A
SA
LSU Eye Center, New Orleans 70112.
Helm
C
C
Insler
M S
MS
Ensley
H E
HE
Pretus
H A
HA
Feigen
L P
LP
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003228:Conjunctiva / Q000276:immunology / Q000378:metabolism; D005123:Eye / Q000187:drug effects / Q000276:immunology*; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology / Q000502:physiology*; D007249:Inflammation / Q000209:etiology; D007975:Leukotriene B4 / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology; D015289:Leukotrienes / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D008084:Lipoxygenase / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011817:Rabbits; D013189:SRS-A / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D013189:SRS-A; D007975:Leukotriene B4; D008084:Lipoxygenase; D010100:Oxygen