Trichosanthin in the treatment of hydatidiform mole. Clinical analysis of 52 cases.
During 1972-1986, 44 of 52 patients (84.6%) with hydatidiform mole were treated successfully with trichosanthin. Of these, 38 (73.1%) had complete spontaneous evacuation and 6 (11.5%) incomplete evacuation. The average time for evacuation of hydatidiform mole was 4.5 +/- 1.64 days. The amount of bleeding was less than 100 ml in 33 patients (75%), while that in 2 of the patients with incomplete evacuation was more than 300 ml. Malignant changes occurred in two of the 44 patients (4.5%). The malignant rate was similar to that (4-12.5, P greater than 0.05) of prophylactic chemotherapy. We consider that thrichosanthin is a better approach to the treatment of hydatidiform mole.
Lu
P X
PX
Department of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Second Medical University.
Jin
Y C
YC
D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy*; D002820:Hydatidiform Mole, Invasive / Q000517:prevention & control; D011247:Pregnancy; D015978:Trichosanthin / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D015978:Trichosanthin