Deleterious effect of anti-insulin antibodies on diabetes control.
We studied the effect of anti-insulin antibodies (AIA) on glycemia control in patients with insulin-dependent diabetes (IDD) by following the AIA titer changes with time. Although expected to remain constant, AIA levels were found to either increase or decrease in most patients. These AIA titer changes correlated significantly with changes in glycohemoglobin but not with changes in insulin dose. The results suggest that AIA may have a deleterious effect on glycemia control in IDD.
Livneh
A
A
Department of Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Avraham
H
H
Bistritzer
T
T
Weisglass
L
L
Theodor
R
R
Sack
J
J
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011863:Radioimmunoassay
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D007330:Insulin Antibodies