[Collagen adhesion-aggregation abnormality (2nd report)--congenital platelet membrane glycoprotein VI deficiency].
Previously, we reported a case of 26-year-old woman with a mild bleeding tendency whose platelets specifically lacked collagen-induced aggregation and adhesion to collagen fibrils. In this report, we investigated the membrane glycoproteins of this patient's platelets and found that her platelets were absent in a 61-kDa glycoprotein, which was identified to be glycoprotein VI (GP VI) of the platelet membrane. Her parents platelets contained about 50% the normal amount of GP VI. These results indicate that our patient has a congenital homozygous GP VI deficiency and that GP VI functions as a collagen receptor.
Shinmyozu
K
K
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Kuriyama
M
M
Okadome
T
T
Maruyama
Y
Y
Maruyama
I
I
Osame
M
M
D000328:Adult; D003094:Collagen; D005260:Female; D006579:Heterozygote; D006801:Humans; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000172:deficiency*; D011956:Receptors, Cell Surface / Q000378:metabolism; D038981:Receptors, Collagen
D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D038981:Receptors, Collagen; D003094:Collagen