Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice.
Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of delta 8- and delta 9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. delta 9-Tetrahydrocannabinol and 11-hydroxy-delta 9-tetrahydrocannabinol exhibited somewhat greater effects than did delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.
Watanabe
K
K
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Kijima
T
T
Narimatsu
S
S
Nishikami
J
J
Yamamoto
I
I
Yoshimura
H
H
D000818:Animals; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice
C020367:11-hydroxy-delta(8)-tetrahydrocannabinol; C001427:11-hydroxy-delta(9)-tetrahydrocannabinol; D013759:Dronabinol