title: Assessment of dry body-weight in haemodialysis patients by the biochemical marker cGMP.
abstract: We investigated whether cGMP might be a suitable marker of ideal weight in chronic haemodialysis patients. In 20 patients on chronic haemodialysis (10 males, 10 females, mean age 55.5 +/- 7.4 years; mean interdialytic weight gain 2.4 +/- 1.1 kg) we determined plasma ANP and cGMP values before and after several haemodialysis treatments. ANP and cGMP before haemodialysis were markedly elevated (ANP 255 +/- 190 pg/ml; cGMP 28.6 +/- 16.2 pmol/ml). A significant decrease was found after haemodialysis (ANP 169 +/- 88 pg/ml; cGMP 13.5 +/- 7.4 pmol/ml). These values were still well above normal. There was a significant positive correlation between excessive body-weight delta P (difference between actual weight and estimated ideal weight), indicating fluid overload and ANP before (r = 0.57; P less than 0.001) and after haemodialysis (r = 0.47; P less than 0.001) as well as cGMP before (r = 0.42; P less than 0.01) and after haemodialysis (r = 0.85; P less than 0.0001). With cGMP and delta P after haemodialysis, the correlation appeared to be close enough for clinical application. All patients with a cGMP value of 18 pmol/ml or more after haemodialysis had an excessive body-weight of at least 0.5 kg. We conclude from these data that the plasma cGMP value determined immediately after haemodialysis is a sensitive marker for hyperhydration in patients with end-stage renal disease.
authors.affiliation: Medizinische Klinik Innenstadt der Universität München, West Germany.
authors.forename: F
authors.initials: F
authors.lastname: Lauster
authors.forename: R
authors.initials: R
authors.lastname: Gerzer
authors.forename: J
authors.initials: J
authors.lastname: Weil
authors.forename: H J
authors.initials: HJ
authors.lastname: Fülle
authors.forename: H
authors.initials: H
authors.lastname: Schiffl
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001834:Body Water / Q000378:metabolism*; D001835:Body Weight; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP