Effect of virus dose and nonoxynol-9 on the genital transmission of SIV in rhesus macaques.
One inoculation of cell-free SIVmac (50 TCID50) caused persistent viremia in nine of 13 female rhesus macaques inoculated intravaginally. Persistent viremia was produced in two of four male rhesus macaques by twice placing cell-free SIVMAC (50 TCID50) onto the skin and urethral os of the penis. Placing a spermicide containing nonoxynol-9 into the vaginal canal prior to repeated intravaginal inoculations of SIV prevented transmission of the virus in three of six female rhesus macaques.
Miller
C J
CJ
California Primate Research Center, University of California, Davis.
Alexander
N J
NJ
Sutjipto
S
S
Joye
S M
SM
Hendrickx
A G
AG
Jennings
M
M
Marx
P A
PA
D000282:Administration, Intravaginal; D000818:Animals; D005260:Female; D005837:Genitalia, Male / Q000382:microbiology*; D008253:Macaca mulatta; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification*; D013089:Spermatocidal Agents / Q000008:administration & dosage; D014621:Vagina / Q000382:microbiology*; D014766:Viremia
D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols