Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis.
The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 micrograms/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 x 10(8) Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 x 10(8), 1 x 10(9) or 1 x 10(10) Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications.
Waymack
J P
JP
US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas.
Guzman
R F
RF
Mason
A D
AD
Pruitt
B A
BA
D000818:Animals; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000401:mortality; D007108:Immune Tolerance / Q000187:drug effects*; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011897:Random Allocation
D011459:Prostaglandins E, Synthetic; C017244:16,16-dimethylprostaglandin E; D007213:Indomethacin