title: Antiviral effect of mangiferin and isomangiferin on herpes simplex virus.
abstract: Using tissue culture technique the present study for the first time indicated the antiviral effect of mangiferin and isomangiferin against type I herpes simplex virus (HSV-I). 4 methods were used for evaluating drug effectiveness (i.e., in vitro drug-on-virus direct action, simultaneous addition of drug-virus-inoculum to cell bottle, virus inoculation preceding drug addition, and drug addition followed by virus inoculation), it was readily found by log determination of HSV-I inhibition that isomangiferin somewhat exceeded such control drugs as acyclovir, idoxuridine, and cyclocytidine in log by 0.27-0.50, and that mangiferin was lower than isomangiferin in log by 0.53. The average plaque reduction rates of mangiferin and isomangiferin were 56.8% and 69.5% respectively. The antiviral effect of mangiferin and isomangiferin was presumably due to their capability of inhibiting virus replication within cells.
authors.affiliation: Department of Microbiology, Jiangxi Medical College, Nanchang.
authors.forename: M S
authors.initials: MS
authors.lastname: Zheng
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Lu
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D010948:Viral Plaque Assay; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; C061492:isomangiferin