[Polyneuropathy in type I multiple endocrine syndrome].
Since 1928, approximately 30 cases of peripheral polyneuropathy consecutive to hypoglycaemia caused by insulinomas or islet cell pancreatic tumours have been published. We report a case of polyneuropathy in a young woman presenting with type I multiple endocrine neoplasia syndrome including multiple insulinomas and parathyroid adenomas. The predominantly motor polyneuropathy was symmetrical and involved both the upper and lower limbs. Biopsy showed muscular atrophy and, in particular non-specific acute axonal lesions. Twelve months after surgery the clinical situation was relatively favourable with resumption of physical activities but persistence of muscular atrophy. Wether hyperparathyroidism was responsible for the neuropathy was uncertain, the subacute post-hypoglycaemia axonal damage being a more likely suspect.
Conri
C
C
Service de Médecine interne, Centre François Magendie, Hôpital du Haut-Levêque, Pessac.
Ducloux
G
G
Lagueny
A
A
Ferrer
M
M
Vital
C
C
D000236:Adenoma / Q000150:complications*; D007516:Adenoma, Islet Cell / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications; D007340:Insulinoma / Q000150:complications*; D010190:Pancreatic Neoplasms / Q000150:complications*; D010282:Parathyroid Neoplasms / Q000150:complications*; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
Polyneuropathie au cours d'un syndrome polyendocrinien de type I.