title: Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus.
abstract: Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
authors.forename: H
authors.initials: H
authors.lastname: Kestler
authors.forename: T
authors.initials: T
authors.lastname: Kodama
authors.forename: D
authors.initials: D
authors.lastname: Ringler
authors.forename: M
authors.initials: M
authors.lastname: Marthas
authors.forename: N
authors.initials: N
authors.lastname: Pedersen
authors.forename: A
authors.initials: A
authors.lastname: Lackner
authors.forename: D
authors.initials: D
authors.lastname: Regier
authors.forename: P
authors.initials: P
authors.lastname: Sehgal
authors.forename: M
authors.initials: M
authors.lastname: Daniel
authors.forename: N
authors.initials: N
authors.lastname: King
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008253:Macaca mulatta; D008264:Macrophages / Q000382:microbiology; D009894:Opportunistic Infections / Q000209:etiology; D012192:Retroviridae Infections / Q000150:complications / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D014162:Transfection; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral