Fatal refractory hyperkalemia due to tumor lysis during primary resection for hepatoblastoma.
Infants with large, rapidly growing tumors of the liver who exhibit preoperative signs of tumor necrosis (elevated uric acid or K+), having received no prior chemotherapy or radiation therapy, may be at risk for acute hyperkalemia during operative manipulation of the mass. In these patients, consideration should be given to careful monitoring of serum potassium throughout operative manipulation; cardiopulmonary bypass, to protect the heart from acute hyperkalemia; or to primary biopsy of the tumor with resection planned after chemotherapy. A case of fatal refractory hyperkalemia due to tumor lysis during a trisegmentectomy for hepatoblastoma in a 7-month-old girl who presented with a large, rapidly growing tumor and hyperuricemia is described.
Lobe
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University of Tennessee, LeBonheur Children's Medical Center, Memphis 38103.
Karkera
M S
MS
Custer
M D
MD
Shenefelt
R E
RE
Douglass
E C
EC
D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology*; D007223:Infant; D008113:Liver Neoplasms / Q000601:surgery*; D011379:Prognosis; D015275:Tumor Lysis Syndrome / Q000209:etiology*