[Study of the GABA-benzodiazepine receptor system of the human myometrium].
A specific [3H] GABA and [14C] flunitrazepam binding sites have been identified in a membrane fraction of human myometrium. The specific binding of [14C] GABA was displaced by unlabelled GABA and bicuculline. It was shown that the binding of [3H] flunitrazepam to membrane preparations is enhanced in the presence of GABA. A similar reciprocal effect of benzodiazepines to enhance [14C] GABA binding has been demonstrated. The present results indicate that GABAA-BD receptors complexes may have a functional significance in human ovary.
Sergeev
P V
PV
Sizov
P I
PI
Dukhanin
A S
AS
Mineeva
E N
EN
D001665:Binding Sites; D002250:Carbon Radioisotopes; D005260:Female; D005445:Flunitrazepam / Q000378:metabolism; D006801:Humans; D009215:Myometrium / Q000737:chemistry* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000032:analysis* / Q000378:metabolism; D014316:Tritium
D002250:Carbon Radioisotopes; D011963:Receptors, GABA-A; D014316:Tritium; D005445:Flunitrazepam
Issledovanie GAMK-benzodiazepinovykh retseptornykh sistem miometriia cheloveka.