title: [Impairment of neutrophil functions: study of a family with a case of juvenile periodontitis].
abstract: Neutrophil function was assessed in family in which only one member suffered from Juvenile Periodontitis (JP). Directed mobility (fMet-Leu-Phe and zymosan-activated plasma) was decreased in all siblings without involving a seric inhibitor. Adhesion was studied by a new method which allows for the evaluation of both adhesive rate and binding strengths. The latter parameters were decreased in the parents neutrophils, but remained increased in a set of twin sisters. The specific receptor induced phagocytosis was altered in all members of the family (FC receptor: IgG-SCR, C3b and mannosylfucosyl receptor: zymosan). The superoxide generation in response to fMet-Leu-Phe was decreased while the PMA response was almost normal. These results suggest an overall abnormality of ligand-receptor interactions (C5a, fMet-Leu-Phe, Fc and C4b receptors), this defect seems to involve some membrane characteristics and underlines the absence of correlation between PMN deficiency and the clinical expression of J.P.
authors.affiliation: Faculté de Chirurgie Dentaire de Marseille.
authors.forename: C
authors.initials: C
authors.lastname: Mattout
authors.forename: J L
authors.initials: JL
authors.lastname: Mege
authors.forename: C
authors.initials: C
authors.lastname: Capo
authors.forename: P
authors.initials: P
authors.lastname: Bongrand
authors.forename: J
authors.initials: J
authors.lastname: Fourel
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D005190:Family; D005260:Female; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D016028:Receptors, Leukocyte-Adhesion; D013481:Superoxides / Q000378:metabolism
chemical_list: D016028:Receptors, Leukocyte-Adhesion; D013481:Superoxides
vernacular_title: Alteration de la fonction des neutrophiles: etude d'une famille avec un cas de parodontite juvenile.