Frequent detection of hepatitis C virus US strain in Japanese hemophiliacs.
Hemophiliacs have been found to be at high risk of hepatitis. Hemophiliacs in Japan receive imported clotting factors as well as domestic ones. Recently we found that hepatitis C virus (HCV) could be classified into at least two types, HCV-US and HCV-J, depending on the nucleotide sequence. We analyzed the nucleotide sequences of virus RNAs from the plasma of patients with hemophilia A or B and found HCV-US in 3 of 4 Japanese hemophiliacs examined.
Hijikata
M
M
Virology Division, National Cancer Center Research Institute, Tokyo.
Kato
N
N
Mori
S
S
Ootsuyama
Y
Y
Nakagawa
M
M
Sugimura
T
T
Ohkoshi
S
S
Kojima
H
H
Meguro
T
T
Taki
M
M
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D006467:Hemophilia A / Q000150:complications / Q000382:microbiology*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000209:etiology*; D006801:Humans; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis*; D065227:Transfusion Reaction; D014481:United States
D012367:RNA, Viral