Reoxygenation injury and antioxidant protection: a tale of two paradoxes.
Under certain circumstances, added antioxidants can protect tissues against reoxygenation injury after ischemia. Yet reperfusing blood carries many antioxidants with it. The implications of this "antioxidant paradox" are discussed.
Gutteridge
J M
JM
Molecular Toxicology, Oklahoma Medical Research Foundation, Oklahoma City 73104.
Halliwell
B
B
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D015427:Reperfusion Injury / Q000188:drug therapy*; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D013481:Superoxides