Neonatal stress and long-term modulation of GABA receptors in rat brain.
Neonatal handling, known to have long-term effects on behaviour and neuroendocrine responses to acute stress, has been found to produce a long-term change in gamma-aminobutyric acid (GABA) receptor binding (Bmax) in whole-brain membranes of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. A significant 10% increase in the binding of [3H] GABA to receptors was evident more than 100 days after handling. There were no differential effects of handling between these two strains, but there was a whole-brain deficit in GABA receptor binding in SHR as compared to WKY animals. Adult corticosterone levels did not correlate with GABA receptor binding.
Bolden
S W
SW
Department of Physiology, University of New England, Armidale, N.S.W., Australia.
Hambley
J W
JW
Johnston
G A
GA
Rogers
L J
LJ
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D005260:Female; D007700:Kinetics; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011963:Receptors, GABA-A / Q000378:metabolism*; D012044:Regression Analysis; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors
D011963:Receptors, GABA-A; D003345:Corticosterone