[The effect of splenic humoral factors on corticosteroid metabolism and the cAMP content in the liver of rats with experimental toxic hepatitis].
Corticosteroid metabolism in the liver and the level of c-AMP in the liver and spleen of rats with experimental toxic hepatitis were investigated after splenin administration. Hydrocortisone metabolites were isolated by a method of two-dimensional thin-layer chromatography. It was shown that their production and the level of c-AMP in the liver and spleen after simulation of experimental hepatitis were considerably reduced. The administration of this drug returned the indices under study to normal. The results obtained demonstrated that humoral factors could produce protective action in toxic liver lesion.
Tron'ko
N D
ND
Korpachev
V V
VV
Kosmina
N M
NM
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000378:metabolism; D002417:Cattle; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D013946:Thymopoietins; D013951:Thymus Hormones; C032841:thymopoietin III; D000242:Cyclic AMP
Vliianie gumoral'nykh faktorov selezenki na metabolizm kortikosteroidov i soderzhanie tsAMF v pecheni krys pri éksperimental'nom toksicheskom gepatite.