[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma].
Marked hypophosphatemia was discovered in 78 patients in the acute period of severe craniocerebral injury. It led to a decrease of the level of 2,3-diphosphoglycerate (2,3 DPG) and ATP in the red cells. The reduced ATP level in the red cells was one of the causes of reduced Ca2+ ATPase activity in their membranes. Intravenous infusion of 6.8% potassium dihydrophosphate solution prevented the development of hypophosphatemia and reduction of the content of 2,3 DPG and ATP in the red cells and Ca2+ ATPase activity in their membranes, which facilitated improvement in the course of acute posttraumatic period in patients with severe craniocerebral injury and decrease of mortality.
Pas'ko
S A
SA
Volosheniuk
T G
TG
D019794:2,3-Diphosphoglycerate; D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000150:complications / Q000628:therapy; D000252:Calcium-Transporting ATPases / Q000097:blood; D003131:Combined Modality Therapy; D003422:Critical Care; D004163:Diphosphoglyceric Acids / Q000097:blood; D006801:Humans; D010710:Phosphates / Q000008:administration & dosage / Q000097:blood; D010760:Phosphorus Metabolism Disorders / Q000097:blood* / Q000209:etiology / Q000628:therapy; D011188:Potassium / Q000008:administration & dosage / Q000097:blood; D017680:Potassium Compounds
D004163:Diphosphoglyceric Acids; D010710:Phosphates; D017680:Potassium Compounds; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; C013216:potassium phosphate; D000252:Calcium-Transporting ATPases; D011188:Potassium
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