Inhaled thiol and phosphorothiol radioprotectors fail to protect the mouse lung.
Pretreatment with an inhaled aerosol of WR 2721, cysteamine or N-acetylcysteine failed to influence the development of radiation-induced lung damage at 14-16 weeks as assessed by a rise in breathing rate in the mouse. In contrast, intraperitoneal WR 2721 400 mg/kg and cysteamine 230 mg/kg were effective indicating that, unlike N-acetylcysteine, they are effective radioprotectors if correctly delivered.
Lockhart
S P
SP
Radiotherapy Research Unit, Institute of Cancer Research, Sutton, Surrey, U.K.
D000111:Acetylcysteine / Q000008:administration & dosage* / Q000627:therapeutic use; D000280:Administration, Inhalation; D000336:Aerosols; D004999:Amifostine / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D003543:Cysteamine / Q000008:administration & dosage* / Q000627:therapeutic use; D008168:Lung / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*
D000336:Aerosols; D003543:Cysteamine; D004999:Amifostine; D000111:Acetylcysteine