Establishment of DDD/1-Mtv-2/Mtv-2, nu/nu and DDD/1-Mtv-2/Mtv-2, nu/+ mice: preliminary characterization in relation to MTV antigen expression and mammary tumorigenesis.
To investigate the effects of the T-cell deprivation on viral mammary tumorigenesis, two double congenic mouse strains of the DDD genetic background, DDD/1-Mtv-2/Mtv-2, nu/nu and DDD/1-Mtv-2/Mtv-2, nu/+, were produced by the cross between DDD/1-Mtv-2/Mtv-2 (DDD-Mtv-2) and DDD/1-nu/nu mice, followed by repeated intercross breedings. Expression of the mouse mammary tumor virus (MTV)-gp52 antigen was demonstrated in the mammary glands of mice from 14 days on, in both -nu/nu and -nu/+ females. Mammary gland development was comparable in both strains, but, the incidence of mammary cancer was lower in the T-cell-deprived mice.
Tsubura
A
A
Department of Pathology, Kansai Medical University, Osaka, Japan.
Morii
S
S
Moriyama
T
T
Matsuzawa
A
A
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D001947:Breeding; D003433:Crosses, Genetic; D005260:Female; D005838:Genotype; D015994:Incidence; D008297:Male; D008321:Mammary Glands, Animal / Q000254:growth & development / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008819:Mice, Nude / Q000235:genetics*; D010641:Phenotype
D000956:Antigens, Viral