title: Prophylaxis against postsplenectomy pneumococcal infection.
abstract: An excess risk of overwhelming sepsis following splenectomy is well established. In view of this, surgical responsibility must embrace the administration of pneumococcal prophylaxis. Current recommendations vary, but routine pneumococcal vaccination, together with penicillin prophylaxis in selected patients, is advocated widely. This retrospective review of 75 patients undergoing splenectomy was undertaken in order to evaluate the extent to which current practice complies with these recommendations. Among surviving patients, the incidence of vaccination with polyvalent pneumococcal vaccine (PPV) was found to vary according to operative indication. All haematological patients received pre-operative PPV. Two-thirds of multitrauma patients were vaccinated, while 42% of patients who required splenectomy following accidental intra-operative trauma received PPV. Only 11% of patients who underwent incidental splenectomy were vaccinated. Long-term antibiotic prophylaxis was commenced in 33% of surviving patients under 20 years of age, and in 8% with underlying malignancy. These results highlight a need for greater vigilance in the administration of pneumococcal prophylaxis, particularly following accidental or incidental splenectomy.
authors.affiliation: Department of Surgery, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Siddins
authors.forename: J
authors.initials: J
authors.lastname: Downie
authors.forename: K
authors.initials: K
authors.lastname: Wise
authors.forename: M
authors.initials: M
authors.lastname: O'Reilly
mesh_terms: D000328:Adult; D000368:Aged; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006402:Hematologic Diseases / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000517:prevention & control*; D012189:Retrospective Studies; D013154:Spleen / Q000293:injuries; D013156:Splenectomy; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
chemical_list: D001428:Bacterial Vaccines; D010406:Penicillins