Cyclic AMP as an intracellular messenger of gonadotrophin-induced steroidogenesis during the development of the embryonic chick ovary.
(1) Ovine luteinizing hormone (LH) stimulates cyclic AMP (cAMP) and progesterone production (P) throughout late ontogeny of the chick ovary and cAMP mimicks LH in stimulating P secretion but: (2) P/cAMP ratios are lower at the earliest stages than at hatching, LH enhancing this tendency. (3) Immediately before hatching, on day 19 time-courses of LH stimulations of cAMP and P are different. (4) cAMP and P respond differently to increasing doses of LH but similarly to increasing doses of forskolin. (5) 1.5 mM dibutyryl cAMP (I) and 100 ng LH (II) increase P maximally, 2.5- and 3.3-fold respectively, but a mixture (I + II) increases P 7.5-fold.
González
C B
CB
Departmento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Cantore
M L
ML
Lantos
C P
CP
Passeron
S
S
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002642:Chick Embryo; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D011374:Progesterone / Q000096:biosynthesis; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D005576:Colforsin; D011374:Progesterone; D003994:Bucladesine; D007986:Luteinizing Hormone; D000242:Cyclic AMP