title: An outbreak of acute gastroenteritis caused by a small round structured virus in a geriatric convalescent facility.
abstract: An outbreak of acute gastroenteritis (AGE) occurred in a 201-bed geriatric convalescent facility in Los Angeles County during December 1988 through January 1989. The attack rate was 55% among residents and 25% among employees. Illnesses were characterized by vomiting and diarrhea to a lesser extent, and the absence of fever. Bacterial and parasitic tests in a sample of patients were negative. A 27 nm small round structured virus (SRSV) was identified in one of 30 stools studied by immune electron microscopy (IEM). While rotavirus and influenza A and B were found in three, one and three cases, respectively, no alternative etiologic agent could be demonstrated for most cases. The outbreak met Centers for Disease Control (CDC) clinical and epidemiologic criteria for Norwalk-like gastroenteritis. The death rate of residents was not elevated beyond baseline during the outbreak; however, one healthy employee had diarrhea and dehydration and died after developing an arrhythmia. An autopsy showed moderate, diffuse lymphocytic and neutrophilic myocarditis, and viral studies found influenza A in left ventricular tissue. Fourteen (25%) of 57 employee cases worked in occupations without routine stool or patient contact. At least nine of these employees lacked evidence of direct fecal contact, and transmission of infection in these cases may have been airborne.
authors.affiliation: Harvard Institute for International Development, Cambridge, Massachusetts.
authors.forename: G A
authors.initials: GA
authors.lastname: Gellert
authors.forename: S H
authors.initials: SH
authors.lastname: Waterman
authors.forename: D
authors.initials: D
authors.lastname: Ewert
authors.forename: L
authors.initials: L
authors.lastname: Oshiro
authors.forename: M P
authors.initials: MP
authors.lastname: Giles
authors.forename: S S
authors.initials: SS
authors.lastname: Monroe
authors.forename: L
authors.initials: L
authors.lastname: Gorelkin
authors.forename: R I
authors.initials: RI
authors.lastname: Glass
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D003967:Diarrhea / Q000209:etiology; D004196:Disease Outbreaks; D005243:Feces / Q000382:microbiology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D009663:Norwalk virus; D009735:Nursing Homes; D009741:Nursing Staff, Hospital; D009784:Occupational Diseases / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D014777:Virus Diseases / Q000453:epidemiology* / Q000382:microbiology; D014839:Vomiting / Q000209:etiology