[Interaction of the serotoninergic and GABA-ergic systems in "psychogenic" amnesia].
The results are analyzed of the influence of blockade of separate components of BD-GABA-iontophoretic complex on activation of memory-trace amnesia under blockade of serotonine PGA synthesis in experiments with conditioned reaction (CR) of passive avoidance in mice. It has been shown that the blockade of serotonine PGA synthesis did not change the behavioral manifestations of amnesia at all terms of testing. The blockade of chlorine channel by picrotoxin and of BD receptors RO15-1788 and RO15-3505 restored the reproduction of the memory trace disturbed against the PGA background; the blockade of GABAA-receptors by bicuculline lost its effectiveness. Activation of serotonin system by sertraline against the PGA background before learning and amnestic influence or before testing of CR of passive avoidance contributed to restoration of CR activating action of bicuculline. It was found that preliminary blockade of PGA serotonine synthesis changed the amnesia development and the character of subsequent restoration of CR of passive avoidance reproduction by blockaders of separate components of BD-GABA-iontophoretic complex.
Il'iuchenok
R Iu
RIu
Filip'eva
N V
NV
D000647:Amnesia / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003864:Depression, Chemical; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D010133:p-Chloroamphetamine
Vzaimodeĭstvie serotoninergicheskoĭ i GAMKergicheskoĭ sistem pri "psikhogennoĭ" amnezii.