Fulminant hepatitis after lisinopril administration.
A case of fulminant hepatitis in a patient taking lisinopril for 5 weeks for arterial hypertension is reported. Jaundice, fever, myalgia, and marked increase in serum aminotransferase activities occurred after 2 weeks of treatment. Continuation of lisinopril administration for 3 weeks after the onset of jaundice was associated with the development of grade III encephalopathy and a marked decrease in prothrombin and proaccelerin levels. This case strongly suggests that lisinopril may induce acute hepatitis and that continuation of the treatment after the onset of jaundice can lead to life-threatening hepatic failure.
Larrey
D
D
Unité de Recherches de Physiopathologie Hépatique (INSERM U-24), Hôpital Beaujon, Clichy, France.
Babany
G
G
Bernuau
J
J
Andrieux
J
J
Degott
C
C
Pessayre
D
D
Benhamou
J P
JP
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D017706:Lisinopril; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D017706:Lisinopril