Suppression of tyrocidine production by purine nucleotides and related substances in Bacillus brevis.
Bacillus brevis (ATCC 8185) produces an antibiotic peptide, tyrocidine. We found that adenosine or 5'-AMP suppressed the production of tyrocidine with half-maximum inhibition at 100-300 microM. This inhibition was specific to the production of tyrocidine since neither adenosine nor 5'-AMP showed any effect on bacterial growth. Cyclic nucleotides had no effect. These results suggest that adenosine, 5'-AMP or its metabolite was specifically involved in the regulation of tyrocidine production.
Oyama
M
M
Laboratory of Biology, Himeji Institute of Technology, Himeji Hyogo, Japan.
Kubota
K
K
D000241:Adenosine / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D009712:Nucleotides, Cyclic / Q000494:pharmacology; D011685:Purine Nucleotides / Q000494:pharmacology*; D014440:Tyrocidine / Q000096:biosynthesis*; D014449:Tyrothricin / Q000096:biosynthesis*
D009712:Nucleotides, Cyclic; D011685:Purine Nucleotides; D014440:Tyrocidine; D014449:Tyrothricin; D000249:Adenosine Monophosphate; D000241:Adenosine