Resorthiomycin, a novel antitumor antibiotic. I. Taxonomy, isolation and biological activity.
Resorthiomycin, a novel antitumor antibiotic, was isolated from the fermentation broth of a strain of Streptomyces collinus by ethyl acetate extraction, silica gel chromatography and HPLC. Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 micrograms/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. On the other hand, this antibiotic does not possess any antibacterial or antifungal activity.
Suzuki
H
H
Institute of Applied Microbiology, University of Tokyo, Japan.
Tahara
M
M
Takahashi
M
M
Matsumura
F
F
Okabe
T
T
Shimazu
A
A
Hirata
A
A
Yamaki
H
H
Yamaguchi
H
H
Tanaka
N
N
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D006528:Carcinoma, Hepatocellular; D002460:Cell Line / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007940:Leukemia L5178; D008113:Liver Neoplasms; D051379:Mice; D012118:Resorcinols / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis
D000903:Antibiotics, Antineoplastic; D012118:Resorcinols; C063431:resorthiomycin