title: [High-molecular polyphosphates and pyrophosphate in cyclosporin- producing Tolypocladium sp. and their role in the processes of growth and antibiotic synthesis].
abstract: The contents of high-energy phosphorous compounds, i.e. three fractions of polyphosphates, pyrophosphate, and ATP were determined in isogenic strains of Tolypocladium sp. differing in cyclosporine production levels. The content of polyphosphates was 1 to 2 orders of magnitude greater than that of pyrophosphate or ATP and did not depend on the strain productivity. During the period of the mycelial intensive growth and at the beginning of antibiotic synthesis, the level of polyphosphates lowered 2-3-fold and the content of pyrophosphate markedly decreased as well. The activities of polyphosphatase and pyrophosphatase during the culture growth and cyclosporine biosynthesis was higher in the highly productive strain.
authors.forename: I V
authors.initials: IV
authors.lastname: Sotnikova
authors.forename: G N
authors.initials: GN
authors.lastname: Telesnina
authors.forename: I N
authors.initials: IN
authors.lastname: Krakhmaleva
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Sazykin
authors.forename: S M
authors.initials: SM
authors.lastname: Navashin
mesh_terms: D003524:Cyclosporins / Q000096:biosynthesis*; D011756:Diphosphates / Q000737:chemistry / Q000378:metabolism*; D066298:In Vitro Techniques; D003904:Mitosporic Fungi / Q000254:growth & development* / Q000378:metabolism; D008970:Molecular Weight; D011122:Polyphosphates / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003524:Cyclosporins; D011756:Diphosphates; D011122:Polyphosphates
vernacular_title: Vysokomolekuliarnye polifosfaty i pirofosfat u produtsenta tsiklo- sporina Tolypocladium sp. i ikh rol' v protsessakh rosta i antibiotikoobrazovaniia.