Down's syndrome: increased enzymatic antioxidative defense is accompanied by decreased superoxide anion generation in blood.
Whole blood leukocytes of DS patients were found to produce less superoxide radical anion than in healthy controls, especially without stimulation with zymosan. This decreased superoxide generation may contribute to the immune system deficiency reported for DS.
Kedziora
J
J
Department of Physiology, Institute of Fundamental Sciences, WAM, Lódź, Poland.
Błaszczyk
J
J
Sibińska
E
E
Bartosz
G
G
D000328:Adult; D002374:Catalase / Q000378:metabolism; D004314:Down Syndrome / Q000097:blood / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000097:blood*
D013481:Superoxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase