[Antidotal effects of sulfhydryl compounds on acute poisonings by sodium ammonium dimethyl-2-(propane-1,3-dithiosulfate) monohydrate, nereistoxin and cartap].
Sodium dimercaptopropanesulphonate (DMPS) and sodium dimercaptosuccinate (DMS) were discovered to be effective antidotes for acute poisoning of insecticides SCD [sodium ammonium dimethyl-2-(propane-1,3-dithiosulfate) monohydrate], nereistoxin (4-N,N-dimethylamino-1,2-dithiolane) and cartap (dihydronereistoxin dicarbamate). In mice, DMPS (250 mg/kg) or DMS (1000 mg/kg) ip 20 min before SCD increased LD50 of ig SCD from 97 to 374 or 251 mg/kg, respectively. The prophylactic effect of DMPS was better than that of DMS. Administration of DMPS prior to cartap increased LD50 of ig cartap from 130 to 375 mg/kg. The therapeutic effect of DMPS was also demonstrated in SCD-poisoned conscious rabbits. DMPS 62.5 mg/kg or DMS 500 mg/kg iv completely antagonized the neuromuscular blockade and respiratory depression caused by SCD, nereistoxin and cartap in anesthetized rabbits. The antagonism of SCD-induced neuromuscular blockade by cysteine (400 mg/kg, iv) was less effective and of shorter duration than that by DMPS and DMS. Dimercaprol 50 mg/kg im showed little effect on SCD-induced paralysis. The antagonistic actions of sulfhydryl compounds on neuromuscular blockade induced by these insecticides probably belong to chemical antagonism.
Cao
B J
BJ
Department of Pharmacology, Wenzhou Medical College, China.
Chen
Z K
ZK
Chi
Z Q
ZQ
D000818:Animals; D003545:Cysteine / Q000627:therapeutic use; D004112:Dimercaprol / Q000627:therapeutic use; D005260:Female; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008387:Marine Toxins / Q000506:poisoning*; D051379:Mice; D011817:Rabbits; D012530:Saxitoxin / Q000031:analogs & derivatives* / Q000506:poisoning; D004113:Succimer / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D013859:Thiocarbamates / Q000506:poisoning; D014494:Unithiol / Q000627:therapeutic use
D007306:Insecticides; D008387:Marine Toxins; D013438:Sulfhydryl Compounds; D013859:Thiocarbamates; D004112:Dimercaprol; C025633:nereistoxin; D012530:Saxitoxin; D014494:Unithiol; C034902:neosaxitoxin; D004113:Succimer; D003545:Cysteine; C032761:carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester