title: Dissociation of the ampicillin-induced lysis of amino acid-deprived Escherichia coli into two stages.
abstract: The ampicillin-induced lysis of amino acid-deprived relA+ Escherichia coli was dissociated into two separate stages. The early stage ("priming") requiring the presence of ampicillin apparently involved the interaction of ampicillin with a target penicillin-binding protein. The later stage ("lysis induction") was ampicillin independent and required only chloramphenicol to relax the RelA-dependent control of peptidoglycan hydrolase activity.
authors.affiliation: Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
authors.forename: A G
authors.initials: AG
authors.lastname: Pisabarro
authors.forename: M A
authors.initials: MA
authors.lastname: De Pedro
authors.forename: E E
authors.initials: EE
authors.lastname: Ishiguro
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000667:Ampicillin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D007700:Kinetics; D013997:Time Factors
chemical_list: D000596:Amino Acids; D000667:Ampicillin