[The external respiratory reaction and its significance for oxygen transport in rats in acute anemic hypoxia].
In anesthetized Wistar rats, the external respiration response, changes of the oxygen transport system's parameters and of total gas exchange, were studied in discrete acute anemia (isovolemic hemodilution with the 6.5% albumin solution). In 3 groups of rats (I--spontaneous breathing and intact pulmonary circulation; II--artificial ventilation of the lungs with a fixed volume; III--embolism of pulmonary vessels), an increase in the lung ventilation was an important compensatory response to acute anemia maintaining a high degree of arterial blood oxygenation in increased perfusion of the lungs. The conjugation of respiratory and circulatory responses plays a major role in the maintenance of gas exchange and gas transport in the organism: separate switching off of compensatory response in one of these systems leads a weakening of compensatory responses in another system.
Chuĭkin
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AE
D000208:Acute Disease; D000740:Anemia / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D006454:Hemoglobins / Q000502:physiology; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D011655:Pulmonary Embolism / Q000097:blood / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000502:physiology*; D012121:Respiration, Artificial
D006454:Hemoglobins
Reaktsiia vneshnego dykhaniia i ee znachenie dlia transporta kisloroda u krys v usloviiakh ostroĭ anemicheskoĭ gipoksii.