Stimulation of growth hormone and corticotropin release by angiotensin II in man.
The intravenous (IV) infusion of angiotensin II (AII) was administered to seven healthy male volunteers in a randomized placebo-controlled study. As expected, AII induced a significant increase in blood pressure and plasma aldosterone concentrations. AII caused a significant increase in corticotropin (ACTH) and growth hormone (GH) release, but had no effect on the release of thyrotropin (TSH) and prolactin (PRL). These findings suggest that peripherally circulating AII might influence ACTH and GH secretion in humans.
degli Uberti
E C
EC
Institute of Clinical Medicine, University of Ferrara, Italy.
Trasforini
G
G
Margutti
A
A
Rossi
R
R
Ambrosio
M R
MR
Pansini
R
R
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone