[Tian-shou liquor on activity of cell membrane and energy metabolism in diabetes mellitus].
The research of Chinese medicine Tian-Shou Liquor(TSL) on the fluidity of the membrane lipid regions of intact erythrocyte (showed by microviscosity, eta), the activity of sodium pump of red cell, the plasma lipid level and sugar concentration in 65 cases of diabetes mellitus were determined before the treatment and a half year after the treatment. 82 normal cases were studied as a control group. The results showed that the diabetic group had an obviously lower fluidity of erythrocyte membrane and activity of sodium pump of red cell than those of normal groups (P less than 0.001). The microviscosity of 27 diabetes patients treated by TSL were markedly decreased when compared with before treatment (P less than 0.01). The changes of activity of sodium pump had no significant difference before and after treatment with TSL. According to the determination of plasma lipid, it was discovered that the total cholesterol concentration and HDL2-C level in diabetes patients were obviously higher and lower than those of normal groups respectively (P less than 0.001). One half Year after treatment, the patients' cholesterol concentration had significantly decreased, but the HDL2-C level were markedly raised by means of comparison between before and after treatment. Blood sugar concentration of 43 cases with TSL treatment decreased evidently (P less than 0.001).
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Institute of Integrated Traditional and Western Medicine, Shanghai Medical University.
D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008875:Middle Aged; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D008076:Cholesterol, HDL; D004365:Drugs, Chinese Herbal; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase