[Endogenous digitalis-like substances and cardiac glycosides: facts and hypotheses].
The review presents the data on endogenous digitalis-like substances the effects of which are imitated by administered cardiac glycosides. It is suggested that the individual differences in the responses of patients to cardiac glycosides, a great range of doses of the drugs causing intoxication as well as the absence of a close correlation between the occurrence of therapeutic and toxic effects and blood plasma glycoside concentration are related to the change of the level of endogenous digitalis-like substances in the organism. The further study of the chemical structure of digitalis-like substances and the mechanism of their secretion opens up new possibilities for practical medicine.
Mikhaĭlov
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D000818:Animals; D002301:Cardiac Glycosides / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004070:Digitalis; D004347:Drug Interactions; D006801:Humans; D009842:Oligopeptides / Q000502:physiology*; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology
D002301:Cardiac Glycosides; D009842:Oligopeptides; D011956:Receptors, Cell Surface
Endogennye digitalispodobnye veshchestva i serdechnye glikozidy: fakty i gipotezy.