Blocking by anti-idiotypic antibodies of monoclonal antibody mediated protection in mice against encephalomyocarditis virus induced diabetes and lethal disease.
Monoclonal antibodies (MA) UM 21.1 and UM 21.2 protect mice against encephalomyocarditis virus (D-variant) induced diabetes and lethal disease. MA-mediated protection in vivo as well as neutralization in vitro could be specifically blocked by anti-idiotypic antibodies.
Vlaspolder
F
F
Eijkman-Winkler Laboratory for Medical Microbiology, Academic Hospital Utrecht, The Netherlands.
Oosterlaken
T A
TA
Harmsen
M
M
van Dijk
P W
PW
Kievit
H
H
Kraaijeveld
C A
CA
Snippe
H
H
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D004686:Encephalomyocarditis virus / Q000276:immunology; D004769:Enterovirus Infections / Q000276:immunology / Q000517:prevention & control*; D007109:Immunity; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D014765:Viral Vaccines