Philadelphia chromosome-negative chronic myelogenous leukemia and chronic myelomonocytic leukemia.
Philadelphia chromosome (Ph)-negative chronic myelogenous leukemia (CML) and chronic myelomonocytic leukemia (CMML) are heterogeneous disorders characterized by various degrees of proliferation, dysplasia, maturation arrest, and monocytosis. In this article, the clinical, laboratory, molecular, and therapeutic aspects of the disease entities are reviewed.
Kantarjian
H M
HM
Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston.
Kurzrock
R
R
Talpaz
M
M
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D011379:Prognosis; D012307:Risk Factors
D000970:Antineoplastic Agents