[Comparative study of serum lipid-bound sialic acid and carcinoembryonic antigen in patients with lung cancer].
Serum LSA and CEA levels were measured in 86 patients with lung cancer, 56 patients with benign pulmonary diseases and 127 normal subjects. The results showed that the diagnostic accuracy rate of LSA for lung cancer (82.4%) was higher than that of CEA (67.6%). LSA was more useful than CEA for diagnosis and differantial diagnosis of lung cancer. CEA was more sensitive to adenocarcinoma of the lung. While LSA was sensitive to small cell lung cancer and squamous cell lung cancer as well. LSA levels and positive rate were related to the stages of lung cancer. LSA was more helpful than CEA for evaluating the status of disease and staging patients. The changes of LSA levels in 33 patients with lung cancer were related to the results of chemotherapy. LSA was superior to CEA for monitoring therapy. Combinative determination of both two markers was better than that of single marker.
Zhu
X
X
Changhai Hospital, Shanghai.
D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000276:immunology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000276:immunology; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000097:blood*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D008055:Lipids; D012794:Sialic Acids; C054080:lipid-associated sialic acid; D019158:N-Acetylneuraminic Acid