[Systemic effects of ultraviolet, visible and infrared radiation in serial whole body irradiation. II. Effect on the immune cells of the skin].
Before and after skin treatment by ultraviolet radiation, infrared radiation or visible light the ability of polymorphonuclear leukocytes (PMN) to form oxygen intermediates was investigated in 31 healthy volunteers. Superoxide production was evaluated photometrically as the reduction of Iodonitrotetrazoliumchloride (INT). After whole body treatment by 4 UV exposures all persons exhibited significantly enhanced rates of INT-reduction for 26-62 days. The in vivo half-time of PMN is 5-7 hours. Therefore a direct effect of irradiation over that long period is rather unlikely, suggesting that mediators should play a crucial role in signal transduction from the skin to the peripheral blood cells. Most likely candidates for connective links are interferon-gamma (IFN-gamma), granulocyte-monocyte colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF).
Müller
G M
GM
Institut für Medizinische Immunologie, Humboldt-Universität zu Berlin.
Scherf
H P
HP
Meffert
H
H
Kohl
A
A
Volk
H D
HD
D005609:Free Radicals; D006801:Humans; D007259:Infrared Rays; D008163:Luminescent Measurements; D009504:Neutrophils / Q000528:radiation effects*; D010789:Phototherapy; D013481:Superoxides / Q000378:metabolism; D014467:Ultraviolet Therapy; D014916:Whole-Body Irradiation
D005609:Free Radicals; D013481:Superoxides
Systemische Effekte der Ultraviolett-, sichtbaren bzw. Infrarot-Strahlung bei seriellen Ganzkörperbestrahlungen. II. Der Einfluss auf die Immunzellen der Haut.