Influence of oat bran on sucrose-induced blood pressure elevations in SHR.
To determine whether oat fiber influences BP, we gave spontaneously hypertensive rats (SHR) a diet high in sucrose and low in protein (calories: sucrose 52%, protein 15%, fat 33%) or a diet low in sucrose and high in protein (calories: sucrose 13%, protein 52%, fat 35%). The amount of fat in these particular diets has not been shown to influence BP, so we modified the 2 diets by replacing fat with oat bran (10% w/w). Accordingly, we examined 4 groups of 5 rats consuming different diets: high sucrose, high sucrose + oat bran, low sucrose, and low sucrose + oat bran. Not unexpectedly, SHR consuming the diet high in sucrose had a significantly higher BP after 2 weeks than those consuming the diet low in sucrose. The significant difference in BP continued over the next 3 weeks. At the end of 6 week duration of study, we found the following BP: SHR ingesting the high sucrose diet, 217 mm Hg +/- 5 (SEM) vs SHR consuming the low sucrose diet, 187 mm Hg +/- 4 (SEM) p less than .0001]. SHR eating the low sucrose diet and consuming supplemental bran showed no significant change in BP after 6 weeks compared to SHR eating the basic diet alone, 188 mm Hg +/- 6 (SEM); however, 5 SHR consuming the high sucrose diet with added oat bran showed a significantly lower BP 200 mm Hg +/- 2 (SEM) than SHR ingesting the basic high sucrose diet devoid of oat bran [p less than .01]. We conclude that addition of oat bran to the diet can ameliorate sucrose-induced BP elevations in SHR.
el Zein
M
M
Department of Medicine, Georgetown University Medical Center, Washington, D.C. 20007.
Areas
J
J
Knapka
J
J
Gleim
G
G
DiPette
D
D
Holland
B
B
Preuss
H G
HG
D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D001835:Body Weight; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D009929:Organ Size; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D013395:Sucrose / Q000494:pharmacology*; D014556:Urine / Q000737:chemistry
D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D013395:Sucrose