title: Fatal Plasmodium falciparum malaria after an inadequate response to quinine treatment.
abstract: A 24-year-old man with severe Plasmodium falciparum malaria died after 77 h of treatment with full parenteral doses of quinine. His peripheral parasitemia at death exceeded the level on admission. Plasma concentrations of quinine were abnormally low throughout. This case emphasizes the importance of pharmacokinetic factors in determining the therapeutic response in severe P. falciparum malaria.
authors.affiliation: Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Looareesuwan
authors.forename: P
authors.initials: P
authors.lastname: Charoenpan
authors.forename: M
authors.initials: M
authors.lastname: Ho
authors.forename: N J
authors.initials: NJ
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Karbwang
authors.forename: D
authors.initials: D
authors.lastname: Bunnag
authors.forename: T
authors.initials: T
authors.lastname: Harinasuta
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D010963:Plasmodium falciparum / Q000254:growth & development; D011803:Quinine / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D011803:Quinine