Rearrangement of the T-cell receptor alpha, beta and gamma chain genes in chronic lymphocytic leukemia.
Simultaneous expression of mature B-cell and T-cell markers and subsequent abrogation of expression of the T-cell surface markers by cytotoxic chemotherapy was reported earlier in a patient (TG) with chronic lymphocytic leukemia (CLL). In addition to rearrangements of the immunoglobulin (Ig) gene loci correlating with phenotypic data, the T-cell receptor (TCR) alpha, beta and gamma chain genes also displayed clonal rearrangements in peripheral blood lymphocyte DNA of TG. The present case shows that in CLL cells not only the expression of B-cell and T-cell specific differentiation antigens but also the rearrangement of Ig as well as TCR alpha, beta and gamma genes may occur simultaneously.
Perl
A
A
Department of Medicine, University of Rochester Medical Center, NY 14642.
DiVincenzo
J P
JP
Ryan
D H
DH
Gergely
P
P
Szigeti
A
A
Feher
J
J
Abraham
G N
GN
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D015139:Blotting, Southern; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor / Q000235:genetics*; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics*; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000276:immunology
D007145:Immunoglobulin kappa-Chains; D007148:Immunoglobulin mu-Chains