99mTc complexes of alpha,alpha-disubstituted, alpha-hydroxy carboxylic acids.
99mTc complexes of 2-ethyl-2-hydrobutyric acid, 2-hydroxyisobutyric acid and (+)- and (-)-citramalic acid are readily prepared in high yield and high purity by reduction of 99mTcO4- in the presence of excess ligand. The resulting agents are very stable in vitro, but can undergo some decomposition during chromatographic analysis unless appropriate precautions are taken. Biodistribution studies in rats and dogs show that these new 99mTc agents accumulate primarily in the kidney and urinary bladder.
Colombo
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Consiglio Nazionale delle Ricerche, Istituto Tecnologie Biomediche, Avanzate, Milano, Italy.
Matarrese
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Fazio
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Deutsch
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D000818:Animals; D004285:Dogs; D004355:Drug Stability; D005260:Female; D006885:Hydroxybutyrates / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging; D008293:Malates / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000000981:diagnostic imaging
D006885:Hydroxybutyrates; D008293:Malates; D015609:Organotechnetium Compounds; C063889:technetium Tc 99m 2-ethyl-2-hydroxybutyric acid; C063890:technetium Tc 99m 2-hydroxyisobutyric acid; C063891:technetium Tc 99m citramalic acid