[A case of pflügeroma or mixed germ cell-sex cord stroma tumor].
We report a case of pflügerome, a tumor now designated by the term "mixed germ cell sex cord and stroma tumor". This infrequent tumor consists in a proliferation of germ cells surrounded by Sertoli-granulosa-type cells and arises in patients with a feminine phenotype and a 46XY karyotype; it should be differentiated from gonadoblastomas that are seen in patients with a female phenotype and a 46XY or 46XX/46XY mosaic karyotype. Prognosis is good and recovery occurs following exeresis. On the basis of their studies on gonadal differentiation in human embryos, the authors propose the following terms: "tumors of the gonadal anlage with male differenciation" for gonadoblastomas, "tumors of the gonadal anlage with female differentiation" for pflügeromes.
Minh
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HN
Service d'Anatomie Pathologique, Centre Hospitalier, Amiens.
Smadja
A
A
Delteil
C
C
Sevestre
C
C
D002454:Cell Differentiation; D004407:Dysgerminoma / Q000196:embryology / Q000473:pathology; D005260:Female; D006066:Gonads / Q000196:embryology; D006801:Humans; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000196:embryology / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000196:embryology / Q000473:pathology*
A propos d'un cas de pflügérome ou "tumeur mixte germinale des cordons sexuels et du stroma".