title: Estimation of epidermal growth factor receptor in 177 breast cancers: correlation with prognostic factors.
abstract: Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of 125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation.
authors.affiliation: Radiotherapy Department, Centre Hospitalo-Universitaire Albert Michallon, Grenoble, France.
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.forename: M
authors.initials: M
authors.lastname: Chedin
authors.forename: C
authors.initials: C
authors.lastname: Souvignet
authors.forename: J
authors.initials: J
authors.lastname: Marron
authors.forename: C
authors.initials: C
authors.lastname: Arnould
authors.forename: E
authors.initials: E
authors.lastname: Chambaz
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors