Cytochrome oxidase deficiency in Alzheimer's disease.
We assayed cytochrome oxidase and other electron transport chain activities in platelet mitochondria isolated from patients with Alzheimer's disease (AD). Five of 6 patients had striking reductions of platelet cytochrome oxidase activity (patient mean, 83.72 +/- 82.99 nmol/min/mg; control mean, 167.14 +/- 36.21 nmol/min/mg; n = 8). Other electron transport chain catalytic activities were not significantly different than control values. AD may be a systemic illness, a primary defect in cytochrome oxidase may be pathogenically important in its production, and the mitochondrial genes encoding cytochrome oxidase subunits may be important in producing the defect.
Parker
W D
WD
Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Filley
C M
CM
Parks
J K
JK
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000201:enzymology*; D001792:Blood Platelets / Q000201:enzymology*; D030401:Cytochrome-c Oxidase Deficiency; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D012016:Reference Values
D003576:Electron Transport Complex IV