Humoral immune response to immediate-early protein of pseudorabies virus in swine with induced or naturally acquired infection.
Pseudorabies virus (PRV) immediate-early (IE) protein is a nonglycosylated polypeptide localized in the nuclei of infected cells. The IE protein is a regulatory protein that is only synthesized during viral replication and is presented to the immune system of PRV-infected swine. Antibodies to the IE protein were demonstrated in swine with induced or naturally acquired infection. However, antiserum raised against purified IE protein could not neutralize PRV in vitro.
Cheung
A K
AK
National Animal Disease Center, USDA, Ames, LA 50010.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D006023:Glycoproteins / Q000096:biosynthesis; D011558:Herpesvirus 1, Suid / Q000276:immunology; D011557:Pseudorabies / Q000276:immunology*; D015531:Radioimmunoprecipitation Assay; D012698:Serologic Tests; D012756:Sheep; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*; D014764:Viral Proteins / Q000096:biosynthesis*
D000914:Antibodies, Viral; D006023:Glycoproteins; D014764:Viral Proteins