[Determination of the concentration of cytochrome c and its antibodies in the blood serum for the diagnosis and prognosis of complications in myocardial infarct patients].
EIA was used to demonstrate that the development of acute ischemia of the heart muscle progressing to necrosis is accompanied by an increase of the concentration of cytochrome c and antibodies against cytochrome c in the blood serum. As regards its specificity and sensitivity, the alteration in the antibody concentration is comparable with that in the myoglobin concentration but it is marked 1 to 3 hours earlier. The high level of antibodies against cytochrome c remaining unchanged for 2 to 3 days in myocardial infarction patients attests to the possibility of a complicated, often relapsing course of the disease. The test for determining antibodies against cytochrome c may be recommended for the control over the patient's status and forecasting the course of myocardial infarction.
Gvatua
N A
NA
Komissarenko
S V
SV
Skok
M V
MV
Solonenko
I N
IN
Veselovskaia
L D
LD
Galitskaia
A K
AK
D000906:Antibodies / Q000097:blood*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis; D003574:Cytochrome c Group / Q000097:blood* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011379:Prognosis; D013997:Time Factors
D000906:Antibodies; D003574:Cytochrome c Group
Opredelenie kontsentratsii tsitokhroma c i antitel k nemu v syvorotke krovi dlia diagnostiki i prognozirovaniia oslozhneniĭ u bol'nykh infarktom miokarda.