title: Nucleotide sequence analysis of SA-OMVV, a visna-related ovine lentivirus: phylogenetic history of lentiviruses.
abstract: The nucleotide sequence analysis of the visna-related South African Ovine Maedi Visna virus (SA-OMVV) demonstrates extensive genetic polymorphism among ovine lentiviruses. Differences between visna virus and SA-OMVV proteins range from 8.5 to 35% mismatched amino acids. Moreover, there is a new open reading frame (orf W) in the central part of the genome. A phylogenetic history calibrated by the divergence and isolation dates of these two ovine lentiviruses shows that radiation of the lentiviridae family is a recent event. Visna virus and SA-OMVV evolved independent of each other for about 42 years. The inferred molecular clock was used to calculate the minimal time elapsed since the divergence of some lentiviruses: 93 years for ovine and caprine lentiviruses, 430 years for ungulate and primate lentiviruses, and roughly 200 years for HIV-1, HIV-2, and SIVAGM. BRU, ELI, and MAL HIV-1 isolates diverged in the early 1960s.
authors.affiliation: Laboratoire de Virologie, Faculté de Médecine Nord, Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Querat
authors.forename: G
authors.initials: G
authors.lastname: Audoly
authors.forename: P
authors.initials: P
authors.lastname: Sonigo
authors.forename: R
authors.initials: R
authors.lastname: Vigne
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics*; D015686:Gene Products, env / Q000235:genetics; D015683:Gene Products, gag / Q000235:genetics; D015684:Gene Products, pol / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D011533:Proviruses / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012190:Retroviridae / Q000235:genetics; D012191:Retroviridae Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D014790:Visna-maedi virus / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D015686:Gene Products, env; D015683:Gene Products, gag; D015684:Gene Products, pol; D012191:Retroviridae Proteins