Thyroid hormone requirement for retinoic acid induction of mouse mammary tumor virus expression.
In normal mouse mammary epithelium, insulin, cortisol, and prolactin are absolute requirements for mouse mammary tumor virus expression. Retinoic acid further increased mouse mammary tumor virus expression two- to threefold but only when triiodothyronine was also present; neither retinoic acid nor triiodothyronine alone had any effect.
Bolander
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Department of Biological Sciences, University of South Carolina, Columbia 29208.
Blackstone
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ME
D000818:Animals; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008321:Mammary Glands, Animal / Q000166:cytology; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D011388:Prolactin / Q000494:pharmacology; D012367:RNA, Viral / Q000187:drug effects / Q000235:genetics; D014212:Tretinoin / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D007328:Insulin; D012367:RNA, Viral; D014284:Triiodothyronine; D014212:Tretinoin; D011388:Prolactin; D006854:Hydrocortisone