title: Purine metabolism in feline lymphomas.
abstract: Deficiency of the purine metabolic enzyme adenosine deaminase causes severe immunodeficiency. Retroviruses have been reported to decrease the activity of adenosine deaminase, and many retroviruses, including feline leukemia virus, cause immunodeficiency. Levels of purine metabolic enzymes including adenosine deaminase and consequences of adenosine deaminase inhibition were investigated in feline leukemia virus-infected fresh tumor cells and infected and uninfected cell lines. No evidence of virus effect on levels of adenosine deaminase or other purine metabolic enzymes was detected. Neoplastic cells demonstrated considerable heterogeneity of activity levels of purine metabolic enzymes.
authors.affiliation: Ohio State University, Bone Marrow Transplant Program, Columbus.
authors.forename: E A
authors.initials: EA
authors.lastname: Copelan
authors.forename: K S
authors.initials: KS
authors.lastname: Waddell
authors.forename: S C
authors.initials: SC
authors.lastname: Johnson
authors.forename: L
authors.initials: L
authors.lastname: Mathes
mesh_terms: D015720:5'-Nucleotidase / Q000032:analysis; D000243:Adenosine Deaminase / Q000032:analysis; D000818:Animals; D002415:Cats; D002460:Cell Line; D003842:Deoxycytidine Kinase / Q000032:analysis; D005256:Leukemia Virus, Feline; D008223:Lymphoma / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*; D010770:Phosphotransferases / Q000032:analysis; D017853:Phosphotransferases (Alcohol Group Acceptor); D011687:Purines / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D011687:Purines; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); D003842:Deoxycytidine Kinase; C020005:deoxyadenosine kinase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase