title: [Nedocromil in the treatment of chronic asthma in children. A double-blind vs placebo study].
abstract: After 2 weeks of observation, Nedocromil has been studied in double blind vs placebo for 8 weeks in 40 children with asthma of medium seriousness. Patients had to record on a clinical diary symptoms (wheezing and cough), beta 2-agonists consumption and collateral effects of the drug. Every 2 weeks patients had a clinical examination and the physician's judgement about the treatment's efficiency was registered. Patients who took the active drug had an improvement in symptoms from the 3rd week of observation and a significative decrease in bronchodilators' consumption. The judgement about the treatment's efficiency was different between physician and patients thus preventing the recognition of the patients who had taken Nedocromil from those who had taken placebo. We think that the different consumption of beta 2-agonists could be the reason for this behaviour between the 2 groups.
authors.affiliation: Istituto di Clinica Pediatrica, Servizio di Allergologia ed Immunologia Infantile, Cagliari, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Corrias
authors.forename: R
authors.initials: R
authors.lastname: Minelli
authors.forename: U
authors.initials: U
authors.lastname: Pelosi
authors.forename: M
authors.initials: M
authors.lastname: Loi
authors.forename: P
authors.initials: P
authors.lastname: Pazzola
authors.forename: G
authors.initials: G
authors.lastname: Cuboni
authors.forename: R
authors.initials: R
authors.lastname: Corda
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D017835:Nedocromil; D010919:Placebos; D015363:Quinolones / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D015363:Quinolones; D017835:Nedocromil
vernacular_title: Il Nedocromil nel trattamento dell'asma cronico infantile. Studio in doppio cieco vs placebo.