[The monoaminergic receptors of the internal organs in rats with a tumor and after partial hepatectomy].
Sensitivity to phenylephrine, isoproterenol, serotonin, oxytocin, acetylcholine and barium chloride of vas deferens uterus und fundus strip was studied comparatively in hepatectomized and sarcoma-45, sarcoma-M1, Walker carcinosarcoma and Zajdela ascites hepatoma bearing rats. The contractile response to monoamines and oxytocin was considerably lower or absent at certain periods after hepatectomy or tumour grafting. Effects of biogenic amine antagonists were also substantially altered. The response to isoproterenol, acetylcholine and barium chloride remained unchanged. Apparently a selective alteration of a response of visceral smooth muscles mediated through alpha-adrenergic and D-serotonin receptors occurred not only during the tumour growth but also in the case of active (extensive) proliferation of the normal tissue.
Gedevanishvili
M D
MD
Gogitidze
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NM
D000818:Animals; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D004837:Epinephrine / Q000502:physiology*; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D006498:Hepatectomy; D008099:Liver / Q000502:physiology*; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000503:physiopathology; D009368:Neoplasm Transplantation; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D017983:Receptors, Catecholamine; D011985:Receptors, Serotonin / Q000187:drug effects*; D012513:Sarcoma, Experimental / Q000503:physiopathology*; D013997:Time Factors; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D011941:Receptors, Adrenergic; D017983:Receptors, Catecholamine; D011985:Receptors, Serotonin; D004837:Epinephrine
Issledovanie monoaminergicheskikh retseptorov vnutrennikh organov u krys s opukhol'iu i posle chastichnoĭ gepatéktomii.