Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
The ability of zinc to enhance the efficacy of commonly used chelating drugs in lead intoxication and to reduce the resulting zinc imbalance, was investigated in rats. The simultaneous zinc supplementation increased urinary lead elimination by calcium disodium ethylenediaminetetraacetate (Ca disodium EDTA) and 2,3 dimercaptosuccinic acid (DMSA). Combination therapy was also effective in potentiating the depletion of blood, hepatic and renal lead by calcium disodium EDTA and D-penicillamine (DPA), renal lead by DMSA and reversal of inhibited blood delta-aminolevulinic acid dehydratase (ALAD) activity by calcium disodium EDTA and DPA. The body zinc status was also maintained as reflected by urinary, blood and tissue levels of zinc.
Flora
S J
SJ
Industrial Toxicology Research Centre, Lucknow, India.
Tandon
S K
SK
D000085:Acetates / Q000627:therapeutic use* / Q000652:urine; D019342:Acetic Acid; D000284:Administration, Oral; D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D015913:Chelation Therapy; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use*; D007854:Lead; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D000623:Porphobilinogen Synthase / Q000097:blood; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D004113:Succimer / Q000627:therapeutic use*
D000085:Acetates; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead; D000622:Aminolevulinic Acid; D004492:Edetic Acid; D004113:Succimer; D000623:Porphobilinogen Synthase; D010396:Penicillamine; D019342:Acetic Acid