Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens.
Triallate (S-2,3,3-trichloroallyl diisopropylthiocarbamate) was tested for the potential to produce delayed neurotoxicity. Hens were given single oral doses ranging from 312.5 to 2500 mg/kg of triallate, 750 mg/kg tri-o-cresyl phosphate (TOCP), or empty gelatin capsules on Days 1 and 21 and were killed on Day 42. In a second experiment, animals were administered daily oral doses of 25-300 mg/kg triallate or 10 mg/kg TOCP for 90 days. In a third experiment, animals were given single oral doses of 2500 mg/kg triallate, 750 mg/kg TOCP, or empty gelatin capsules and killed after 24 hr. Delayed neurotoxicity was observed only in TOCP-treated animals. Animals given daily doses of 300 mg/kg triallate became moribund after 30 days; however, histological examination revealed no lesions characteristic of organophosphorus-induced delayed neurotoxicity. Neurotoxic esterase was not significantly altered in triallate-treated animals while it was 95% inhibited in TOCP-treated animals. Plasma butyrylcholinesterase increased significantly 24 hr after treatment with triallate in a dose-dependent manner. In summary, triallate, a thiocarbamate, did not produce neurotoxicity which has been previously reported for some dithiocarbamates.
Lapadula
D M
DM
Duke University Medical Center, Department of Pharmacology, Durham, North Carolina 27710.
Johannsen
F
F
Abou-Donia
M B
MB
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000097:blood*; D002645:Chickens; D002802:Cholinesterases / Q000097:blood*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D009420:Nervous System / Q000187:drug effects* / Q000473:pathology; D013859:Thiocarbamates / Q000633:toxicity*; D014214:Triallate / Q000633:toxicity*; D014317:Tritolyl Phosphates / Q000633:toxicity
D013859:Thiocarbamates; D014317:Tritolyl Phosphates; D014214:Triallate; D002091:Butyrylcholinesterase; D002802:Cholinesterases; C025541:tri-o-cresyl phosphate