title: Hairy leucoplakia--a clinical, histopathological and ultrastructural study in 33 patients.
abstract: Thirty-three cases of hairy leucoplakia (HL) in HIV-positive patients were studied. The most frequent clinical presentation was the development of corrugated plaques on the lateral sides of the tongue without spiculations on the surface. In all biopsies, herpetic-type viral inclusions were found. In 12 out of 14 cases in whom an electromicroscopic study was carried out, only viral particles of the herpes group were found. Human papillomavirus (HPV) was not demonstrated, although by means of immunohistochemistry, positive labelling for HPV was found in 95% of the cases. The aetiopathological significance of these findings remains to be evaluated.
authors.affiliation: Section of Dermatology, Hospital de la Princesa, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Aragües
authors.forename: J
authors.initials: J
authors.lastname: Sanchez Perez
authors.forename: J
authors.initials: J
authors.lastname: Fraga
authors.forename: E
authors.initials: E
authors.lastname: Burgos
authors.forename: A
authors.initials: A
authors.lastname: Noguerado
authors.forename: A
authors.initials: A
authors.lastname: Garcia Diez
mesh_terms: D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000473:pathology; D006564:Herpesviridae / Q000302:isolation & purification; D006801:Humans; D007972:Leukoplakia, Oral / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D014059:Tongue / Q000473:pathology / Q000648:ultrastructure