Lipid peroxidation caused by hyperthermic perfusion of rat liver.
The data presented support the premise that hyperthermia-induced hepatocellular injury is the end result of lipid peroxidation. Evidence for lipid peroxidation is the formation of diene conjugates and the decrease in microsomal P450 and glucose-6-phosphatase activity during hyperthermic liver perfusion.
Skibba
J L
JL
Ellis Fischel State Cancer Center, Columbia, MO 65203.
Powers
R H
RH
Stadnicka
A
A
Kalbfleisch
J H
JH
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D015227:Lipid Peroxidation; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D011916:Rats, Inbred F344
D003577:Cytochrome P-450 Enzyme System; D005952:Glucose-6-Phosphatase; D005978:Glutathione