Cyclic CMP (cytidine 3',5'-monophosphate) suppresses changes in human sperm amplitude of lateral head displacement and hyperactivation.
The dibutyryl analog of cCMP suppressed sperm amplitude of lateral head displacement and hyperactivation. Sperm motility was inhibited by dibutyryl cCMP with a shift toward less linear trajectory sperm movements. The results suggest a role of cCMP as an inhibitory signal on sperm motility patterns related to sperm capacitation.
Chan
P J
PJ
Dept of Gynecology and Obstetrics, Loma Linda University School of Medicine, California 92354.
Tredway
D R
DR
Henig
I
I
Prough
S G
SG
D000242:Cyclic AMP / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D013075:Sperm Capacitation / Q000187:drug effects; D013077:Sperm Head / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects*
D000242:Cyclic AMP