Continuous removal of leucocytes during early gram-negative septicemia reduces plasma levels of endotoxin and improves cardiac performance.
The effect of filter leucapheresis as treatment of gram-negative septicemia was studied in an experimental porcine model. In 7 matched pairs of animals, one of the animal groups received filter leucapheresis starting 2 h after the induction of septicemia. The other animal group acted as a non-treated control. A calculated mean number of 15 x 10(9) white blood cells were removed. Animals submitted to leucapheresis showed lower levels of circulating endotoxin, diminished degree of granulocyte activation and higher cardiac output when compared to the non-treated controls. The increased cardiovascular performance indicated a beneficial effect of selective leucafiltration during early gram-negative septicemia. Lower levels of circulating endotoxin and less active PMNs might contribute to these changes.
Røkke
O
O
Department of Surgery, Tromsø University Hospital, Norway.
Rekvik
O P
OP
Revhaug
A
A
D000818:Animals; D001784:Blood Gas Analysis; D002464:Cell Migration Inhibition; D004731:Endotoxins / Q000097:blood*; D004927:Escherichia coli Infections / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D007937:Leukapheresis; D007958:Leukocyte Count; D009504:Neutrophils / Q000502:physiology; D018805:Sepsis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013552:Swine
D004731:Endotoxins