[The mutagenic action of the dust of natural zeolites and chrysotile asbestos].
The cell chemiluminescence method was used to demonstrate the ability of asbest and zeolite dusts from 8 deposits of the USSR to induce generation of free oxygen radicals in the phagocytosing cells suspension. It has been found that asbest and zeolite (0.01 and 0.05 mg/ml) increase levels of cells with chromosome aberrations in human cell cultures. The cytogenetic effect of asbest was inhibited by superoxide dismutase (50 mg/ml). The damaging effect of zeolite was decreased by the pharmacological drug bemithyl (0.007-0.07 mM) and completely eliminated by catalase (20 mg/ml). The results obtained indicate that mutagenic effect of dust particles of asbest and zeolite is mediated by oxygen radicals.
Durnev
A D
AD
Suslova
T B
TB
Cheremisina
Z P
ZP
Dubovskaia
O Iu
OIu
Nigarova
E A
EA
Korkina
L G
LG
Seredenin
S B
SB
Velichkovskiĭ
B T
BT
D000538:Aluminum Silicates / Q000633:toxicity*; D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D017632:Asbestos, Serpentine; D002478:Cells, Cultured / Q000187:drug effects; D002869:Chromosome Aberrations; D004391:Dust / Q000009:adverse effects*; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D010101:Oxygen Consumption / Q000187:drug effects; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017641:Zeolites
D000538:Aluminum Silicates; D017632:Asbestos, Serpentine; D004391:Dust; D005609:Free Radicals; D009153:Mutagens; D017641:Zeolites; D001194:Asbestos
Issledovanie mutagennogo deĭstviia pyli prirodnykh tseolitov i khrizotil-asbesta.