title: Longitudinal analysis of antibodies to histones, Sm-D peptides and ubiquitin in the serum of patients with systemic lupus erythematosus, rheumatoid arthritis and tuberculosis.
abstract: A longitudinal analysis of 12 lupus patients has been undertaken to assess their autoantibody reactivity by ELISA with histones, Sm-D peptides, ubiquitin and DNA. As controls patients with rheumatoid arthritis and tuberculosis were studied. Whereas the control groups showed little evidence of autoantibody reactivity 25% or more of the lupus patients had raised levels of autoantibodies against eight of the nine antigens tested. Of particular note was the fact that approximately 70% of the blood tested possessed antibodies reacting with Sm-D peptide 1-20. In contrast only one patient had anti-Sm antibodies by counter immunoelectrophoresis. In general the levels of antibodies to core histones reflected disease activity unlike the levels of anti-H1 antibodies. High levels of antibodies to ubiquitin often seemed to correlate inversely with active lupus and DNA antibody levels.
authors.affiliation: Laboratoire d'Immunochimie, Centre National de la Recherche Scientifique, Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Muller
authors.forename: S
authors.initials: S
authors.lastname: Barakat
authors.forename: R
authors.initials: R
authors.lastname: Watts
authors.forename: P
authors.initials: P
authors.lastname: Joubaud
authors.forename: D
authors.initials: D
authors.lastname: Isenberg
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006657:Histones / Q000276:immunology*; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged; D017411:Ribonucleoproteins, Small Nuclear; D014376:Tuberculosis / Q000276:immunology*; D014452:Ubiquitins / Q000276:immunology*; D055517:snRNP Core Proteins
chemical_list: D000906:Antibodies; D001324:Autoantigens; D006657:Histones; D017411:Ribonucleoproteins, Small Nuclear; D014452:Ubiquitins; D055517:snRNP Core Proteins