title: Cyclic adenosine monophosphate (cAMP)-induced potentiation of synaptic responses in Helix neurons.
abstract: 1. The effect of intracellularly injected cAMP on the amplitude of excitatory postsynaptic potentials was studied using identified neurons of the snail Helix pomatia. 2. In 25% of the experiments, postsynaptic cAMP elevation caused a pronounced augmentation of the excitatory postsynaptic potential (EPSP) amplitude, lasting up to 15-30 min. 3. The results suggest that a cAMP increase in the postsynaptic neuron may be involved in the enhancement of synaptic efficiency.
authors.affiliation: Brain Research Institute, All-Union Center of Mental Health, USSR Medical Academy, Moscow.
authors.forename: O V
authors.initials: OV
authors.lastname: Borisova
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000494:pharmacology*; D006372:Helix, Snails / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*
chemical_list: D000242:Cyclic AMP