Studies on vaccination against papillomaviruses: the immunity after infection and vaccination with bovine papillomaviruses of different types.
Calves, free of antibodies to bovine papillomaviruses (BPV), were reared in isolation. One was infected with BPV-2, developed tumours and was resistant to homologous reinfection. Groups of calves were infected with BPV-2, BPV-5 or BPV-6; they all developed and subsequently rejected type-specific tumours. They were then infected with BPV-4; they were not immune and oral papillomas were induced. Groups of animals were vaccinated by intramuscular preparations of purified BPV-4 and BPV-6 and were challenged with homologous virus; all were immune to reinfection. An earlier experiment had shown this to be true for BPV-2. Two calves, immune to BPV-6, were not immune to BPV-1. These experiments, although they do not cover all the possibilities of reciprocal immunisation and challenge, indicate that prophylactic immunity to a range of papillomaviruses is type-specific. This is the first clear demonstration of this phenomenon in the papillomavirus group.
Jarrett
W F
WF
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden.
O'Neil
B W
BW
Gaukroger
J M
JM
Smith
K T
KT
Laird
H M
HM
Campo
M S
MS
D000818:Animals; D052688:Bovine papillomavirus 1; D052697:Bovine papillomavirus 4; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D015151:Immunoblotting; D008854:Microscopy, Electron; D027383:Papillomaviridae; D013045:Species Specificity; D014412:Tumor Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary*