title: Histaminergic H1, serotoninergic, beta adrenergic and dopaminergic receptors in human osteoarthritic cartilage.
abstract: Using radioligand binding assays, histaminergic H1, serotoninergic, dopaminergic and Beta adrenergic receptors were studied in human normal and osteoarthritic cartilage. The four studied receptors were present in normal cartilage; serotoninergic, dopaminergic and Beta adrenergic receptors were significantly increased in osteoarthritic cartilage while histaminergic H1 receptors were significantly increased only in osteophytic cartilage. The results are consistent with a non specific activation of osteoarthritic chondrocytes.
authors.affiliation: Département de Rhumatologie Hôpital Edouard Herriot, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Vignon
authors.forename: P
authors.initials: P
authors.lastname: Broquet
authors.forename: P
authors.initials: P
authors.lastname: Mathieu
authors.forename: P
authors.initials: P
authors.lastname: Louisot
authors.forename: M
authors.initials: M
authors.lastname: Richard
mesh_terms: D002358:Cartilage, Articular / Q000032:analysis*; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism*; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D011954:Receptors, Dopamine / Q000032:analysis*; D011968:Receptors, Histamine / Q000032:analysis*; D011985:Receptors, Serotonin / Q000032:analysis*
chemical_list: D011943:Receptors, Adrenergic, beta; D011954:Receptors, Dopamine; D011968:Receptors, Histamine; D011985:Receptors, Serotonin