Human alpha tumor necrosis factor does not damage cultures containing rat Schwann cells and sensory neurons.
The effects of recombinant human alpha tumor necrosis factor (alpha-TNF) were compared with those of cytotoxic serum from patients with the acute Guillain-Barré syndrome (GBS) in myelinated cultures containing only rat Schwann cells and dorsal root ganglion neurons. Alpha-TNF did not damage rat peripheral nervous system tissue in culture. These observations suggest that alpha-TNF is not responsible for the cytotoxic activity of acute GBS serum in culture.
Mithen
F A
FA
Department of Veterans Affairs, John Cochran Medical Center, St. Louis, MO.
Colburn
S
S
Birchem
R
R
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D004622:Embryo, Mammalian; D005727:Ganglia, Spinal / Q000166:cytology; D006801:Humans; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D009475:Neurons, Afferent / Q000166:cytology* / Q000187:drug effects; D011129:Polyradiculoneuropathy / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012583:Schwann Cells / Q000166:cytology* / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D003470:Culture Media; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha