title: Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus.
abstract: Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N-methyl-D-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, suggesting that NMDA receptors may contribute to the resting activity of MVN neurons.
authors.affiliation: Department of Psychology, University of Otago, Dunedin, New Zealand.
authors.forename: P F
authors.initials: PF
authors.lastname: Smith
authors.forename: C L
authors.initials: CL
authors.lastname: Darlington
authors.forename: J I
authors.initials: JI
authors.lastname: Hubbard
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D006168:Guinea Pigs; D010879:Piperazines / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*; D014726:Vestibular Nuclei / Q000378:metabolism / Q000502:physiology*
chemical_list: D003986:Dibenzocycloheptenes; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid