title: Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury.
abstract: Systemic inflammation promotes multiple organ failure through the induction of diffuse microvascular leak. Inflammatory cells such as neutrophils propagate this process. Tissue injury by neutrophils may be viewed as a normal process, inflammation, that has become uncontrolled and generalized. Multiple inflammatory stimuli synergistically promote neutrophil-mediated tissue injury in priming and activation sequences. In some settings, cellular priming is mediated by platelet-activating factor and can be prevented by platelet-activating factor antagonists. Inhibiting cellular priming could be efficacious in the therapy of multiple organ failure.
authors.affiliation: University of Colorado Health Sciences Center, Denver 80262.
authors.forename: B O
authors.initials: BO
authors.lastname: Anderson
authors.forename: A H
authors.initials: AH
authors.lastname: Harken
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000150:complications; D008168:Lung / Q000201:enzymology / Q000378:metabolism*; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology*; D009504:Neutrophils / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism; D010972:Platelet Activating Factor / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000378:metabolism
chemical_list: D004731:Endotoxins; D010972:Platelet Activating Factor; D009195:Peroxidase