Facioscapulohumeral muscular dystrophy gene in Dutch families is not linked to markers for familial adenomatous polyposis on the long arm of chromosome 5.
Cosegregation of facioscapulohumeral muscular dystrophy (FSHD) and familial adenomatous polyposis (FAP) has been described in two small families. The gene for FAP is located on the long arm of chromosome 5. We studied two large Dutch families with FSHD and found no evidence for linkage with gene markers closely linked to FAP. These results strongly suggest that the FSHD gene segregating in the Dutch families is not localized close to the FAP locus on chromosome 5.
Wijmenga
C
C
Department of Neurology, University Hospital, Leiden, The Netherlands.
Frants
R R
RR
Brouwer
O F
OF
van der Klift
H M
HM
Meera Khan
P
P
Padberg
G W
GW
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5; D005152:Facial Muscles / Q000503:physiopathology*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D009426:Netherlands