[Granulocytes and oxidative metabolism: role of monoclonal antibodies in superoxide anion release from neutrophils].
We studied the effects on the granulocyte oxidative metabolism of some monoclonal antibodies reacting with a membrane surface antigen fundamental for the functions of these cells. The aim of this investigation was to evaluate the role of CD11b/CD18 membrane glycoproteins on superoxide release from granulocytes. The preincubation with MoAbs 60.1, OKM1, 60.3 determined a significant decrease of anion release from granulocytes stimulated by fMLP.
Mazzone
A
A
Dipartimento di Medicina Interna e Terapia Medica, Università di Pavia.
Pasotti
D
D
Fioravanti
A
A
Uccelli
E
E
Freddi
E
E
Nardecchia
L
L
Bertoldi
M
M
D000911:Antibodies, Monoclonal; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000378:metabolism; D010084:Oxidation-Reduction; D013481:Superoxides / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine
Integrine granulocitarie e metabolismo ossidativo: ruolo di alcuni anticorpi monoclonali sulla modulazione del rilascio di anione superossido dai neutrofili.