title: [The mechanism of the effect of interleukin-1 on the glucocorticoid level of the blood: the absence of a direct action of interleukin-1 on adrenal cortex cells].
abstract: The investigation is devoted to the problem of interaction of the body neuroendocrine and immune systems. A study was made of possible mechanisms of stimulating action of IL-1, a cellular mediator of the immune system, on glucocorticoid function of the hypothalamic-pituitary-adrenocortical system. RIA and fluorescence methods as well as methods for obtaining IL-1 from activated rabbit leukocytes were employed. IL-1 was shown to increase the plasma level of corticosterone in rats in ip administration. It also produced a direct effect on the secretion of adrenal cells without enhancing ACTH stimulating action on them. The results of the investigation and literature data show that IL-1 action on the hypothalamic-pituitary-adrenocortical system is implemented through its influence on neurons of the cerebral hypothalamic areas secreting the corticotropin releasing factor.
authors.forename: E G
authors.initials: EG
authors.lastname: Rybakina
authors.forename: K
authors.initials: K
authors.lastname: Salai
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
authors.forename: E K
authors.initials: EK
authors.lastname: Shkhinek
authors.forename: M P
authors.initials: MP
authors.lastname: Lesnikova
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000097:blood*; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015383:Zona Fasciculata / Q000187:drug effects / Q000378:metabolism; D015384:Zona Glomerulosa / Q000187:drug effects / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D007375:Interleukin-1; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
vernacular_title: K mekhanizmu vliianiia interleĭkina-1 na uroven' gliukokortikoidov v krovi: otsutstvie priamogo deĭstviia interleĭkina-1 na kletki kory nadpochechnikov.