Superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis.
The delta 4-pathway of testosterone biosynthesis in leydig cells, widely believed to proceed through pregnenolone--greater than pregnenedione--greater than progesterone route catalyzed by 5 delta-3 beta-hydroxysteroid dehydrogenase and delta 5-delta 4-isomerase respectively is shown to pass through an alternate pathway mediated by superoxide dismutase and peroxidase. A built-in regulatory switch is incorporated in this route, with the superoxide dismutase inducible upon LH-stimulation of the leydig cells.
Pradeep
K G
KG
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.
Seerwani
N
N
Laloraya
M
M
Nivsarkar
M
M
Verma
S
S
Singh
A
A
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007700:Kinetics; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis*
D013481:Superoxides; D013739:Testosterone; D007986:Luteinizing Hormone; D013482:Superoxide Dismutase