title: Influence of chemotherapeutic agents on superoxide anion production by human polymorphonuclear leukocytes.
abstract: The effects of 11 chemotherapeutic agents on superoxide anion (O2-) production were examined in human polymorphonuclear leukocytes (PMNL). All drugs, except predonine, were found to suppress O2- production in PMNL. Adriamycin (doxorubicin), mitomycin C, vindesine, cisplatin, etoposide, nimustine, and pepleomycin suppressed O2- production at relatively low drug concentrations, whereas methotrexate, 5-fluorouracil and vincristine suppressed O2- production at high drug concentrations. Time-dependent suppression of O2- production was evaluated in four drugs, namely Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), cisplatin, vindesine, and methotrexate. Only Adriamycin showed suppressive effect on PMNL-derived O2- production in a time-dependent manner. Production of O2- by PMNL is a fundamental element for its bactericidal activity. The authors' results showed suppression of O2- production in PMNL in the presence of chemotherapeutic agents. This indicates a relationship between chemotherapy drugs and susceptibility to infection. The influence of chemotherapeutic agents on O2- production by PMNL should thus be taken into consideration when assessing defense mechanisms and susceptibility to infection of patients treated with these drugs.
authors.affiliation: Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
authors.forename: A
authors.initials: A
authors.lastname: Motohiro
authors.forename: T
authors.initials: T
authors.lastname: Kuda
authors.forename: H
authors.initials: H
authors.lastname: Aso
authors.forename: M
authors.initials: M
authors.lastname: Ohta
mesh_terms: D000838:Anions; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000097:blood*
chemical_list: D000838:Anions; D000970:Antineoplastic Agents; D013481:Superoxides