Synthesis and pharmacological study of new N-methyl 1,2,3-triazole derivatives of 2-cyano chromones.
The reaction of various 2-cyano chromones with diazomethane generated a series of 21 N-methyl triazoles, with a benzopyrone moiety and divided into three isomeric groups. The anti-inflammatory, psychotropic and anti-allergic effects of these new compounds were evaluated. The results obtained did not confirm their expected potentialities.
Mouysset
G
G
Département de Chimie, UFR de Pharmacie, Toulouse, France.
Payard
M
M
Couquelet
J
J
Bastide
P
P
Stenger
A
A
Delhon
A
A
Tisne-Versailles
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors; D006967:Hypersensitivity / Q000188:drug therapy*; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D016861:Cyclooxygenase Inhibitors; D009570:Nitriles; D011619:Psychotropic Drugs; D011963:Receptors, GABA-A; D014230:Triazoles