title: Expression of major histocompatibility complex antigens on inflammatory peripheral nerve lesions.
abstract: The expression of major histocompatibility complex (MHC) antigens by cells of the rat peripheral nervous system (PNS) was studied using a model of peripheral nerve transplantation. Monoclonal antibodies to polymorphic determinants of MHC class I and class II (Ia) molecules were used to determine donor or recipient origin of MHC antigen-bearing cells in nerve allografts. The expression of class I and class II antigens by PNS parenchymal cells was modified during varying alloimmune conditions. Baseline, constitutive expression of class I antigens on endothelial and perivascular cells and class II antigens on interstitial cells were identified. Decreased MHC antigen expression was noted following in vitro culture of nerve allografts prior to implantation. After transplantation, enhanced donor-derived MHC antigen expression was demonstrated by both cultured and untreated allograft endothelial, perivascular and interstitial cells in a pattern which was distinct from isografts. This data supports a concept of perivascular monocytic and/or parenchymal cell (Schwann cell or resident macrophage-like cell) activity as the resident antigen-presenting cell for PNS immune processes.
authors.affiliation: Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia.
authors.forename: L T
authors.initials: LT
authors.lastname: Yu
authors.forename: A
authors.initials: A
authors.lastname: Rostami
authors.forename: W K
authors.initials: WK
authors.lastname: Silvers
authors.forename: D
authors.initials: D
authors.lastname: Larossa
authors.forename: W F
authors.initials: WF
authors.lastname: Hickey
mesh_terms: D000818:Animals; D006085:Graft Survival; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000637:transplantation; D013979:Tibial Nerve / Q000637:transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II