Biological activities of racemomycin-B, beta-lysine rich streptothricin antibiotic, the main component of Streptomyces lavendulae OP-2.
Racemomycin-B (RM-B), the main component of Streptomyces lavendulae OP-2 which is the basis of 50% of the antibiotics produced, is a streptothricin antibiotic which contains three beta-lysine moieties in the molecule. RM-B had antimicrobial activity against plant-pathogenic microorganisms and growth-inhibitory activity against the root of Brassica rapa L. at the concentration of 50 ppm. It strongly inhibited the growth of Pseudomonas syringae pv. tabaci IFO-3508 (minimum inhibitory concentration (MIC): 0.4 microgram/ml), and also showed antifungal activity against six kinds of Fusarium oxysporum species (MIC: 0.1-2.0 micrograms/ml). The antimicrobial activity of RM-B was much stronger than those of RM-A and -C which contain, respectively, one and two beta-lysine moieties in their molecules. The above activities of RM-A, -C and -B were thus in the order of -B greater than -C greater than -A: namely, the biological activity of racemomycin compounds tended to be stronger with increase in the number of beta-lysine moieties in the molecule.
Inamori
Y
Y
Osaka University of Pharmaceutical Sciences, Japan.
Amino
H
H
Tsuboi
M
M
Yamaguchi
S
S
Tsujibo
H
H
D005670:Fusarium / Q000187:drug effects*; D008239:Lysine / Q000031:analogs & derivatives*; D011549:Pseudomonas / Q000187:drug effects*; D013309:Streptothricins / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C019594:racemomycin; C065591:beta-lysine; D013309:Streptothricins; D008239:Lysine