Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction.
Epstein-Barr virus DNA was detected by polymerase chain reaction in a paraffin-embedded block of an undifferentiated lymphoepithelial gastric carcinoma but was absent in a poorly differentiated gastric adenocarcinoma which also had pronounced lymphoid stroma. This is the first report, to our knowledge, of a lymphoepithelial carcinoma of the stomach. The association with Epstein-Barr virus and the distinctive histologic appearance justify the separate classification of undifferentiated lymphoepithelial carcinomas of the stomach similar to those of the nasopharynx from adenocarcinomas with lymphoid stroma.
Burke
A P
AP
Department of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, D.C.
Yen
T S
TS
Shekitka
K M
KM
Sobin
L H
LH
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000473:pathology
D004279:DNA, Viral