title: Comparative clinical study of porous hydroxyapatite and decalcified freeze-dried bone in human periodontal defects.
abstract: Interproximal bony defects were treated with either porous hydroxyapatite (PHA) or decalcified freeze-dried bone allograft (DFDB) implants at two different clinical centers. Twelve paired defects in 12 patients were treated at each center. Six months post-surgically the defects were measured to assess changes from the presurgical status. No statistically significant differences were found between the groups in changes in gingival fluid, bleeding index, plaque index, or tooth mobility. The porous hydroxyapatite implant produced greater reduction in pocket depth (P = 0.03) and more gain in clinical attachment level (P = 0.001) and defect fill (P = 0.001) when compared with DFDB grafted sites. This study indicates that more clinical resolution of interproximal periodontal defects in humans can be obtained with the use of PHA than with the use of DFDB.
authors.affiliation: UCLA School of Dentistry.
authors.forename: S
authors.initials: S
authors.lastname: Oreamuno
authors.forename: V
authors.initials: V
authors.lastname: Lekovic
authors.forename: E B
authors.initials: EB
authors.lastname: Kenney
authors.forename: F A
authors.initials: FA
authors.lastname: Carranza
authors.forename: H H
authors.initials: HH
authors.lastname: Takei
authors.forename: B
authors.initials: B
authors.lastname: Prokic
mesh_terms: D000328:Adult; D000539:Alveolar Process / Q000473:pathology; D000543:Alveoloplasty / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods; D003648:Decalcification Technique; D003774:Dental Plaque Index; D017886:Durapatite; D005612:Freeze Drying; D006801:Humans; D006882:Hydroxyapatites; D010510:Periodontal Diseases / Q000473:pathology / Q000601:surgery*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D019736:Prostheses and Implants; D011897:Random Allocation; D013499:Surface Properties
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite