Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease.
Cerebellar kuru plaques in 2 cases of Creutzfeldt-Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt-Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.
Suenaga
T
T
Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
Hirano
A
A
Llena
J F
JF
Ksiezak-Reding
H
H
Yen
S H
SH
Dickson
D W
DW
D000368:Aged; D002531:Cerebellum / Q000737:chemistry* / Q000648:ultrastructure; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D014452:Ubiquitins / Q000032:analysis*
D014452:Ubiquitins