Immunohistochemistry in lymphoproliferative diseases.
In diagnostic pathomorphology of lymphoproliferative diseases, immunohistochemical methods are of great importance. These methods help to elucidate the following issues: reactive or malignant nature of a lesion, origin of atypical cells (lymphoreticular or other), type of malignant lymphoma (Hodgkin's disease or malignant non-Hodgkin lymphoma, NHL), grade of malignancy, T- or B-cell origin and subtype of NHLs. All results of immunohistochemistry should be carefully scrutinized in the light of routine pathomorphological findings. The possibilities of immunohistochemistry are demonstrated by two examples: 1. Origin and stage of differentiation of B-cell chronic lymphocytic leukaemia cells with special emphasis on the presence of follicular dendritic reticulum cells in the lymph nodes of a few, otherwise typical cases of CLL. 2. Description of two cases of a new type of NHL that contains intrasinusoidal B-cells. Monoclonal plasma cells with immunoglobulins of the same isotypes as those of intrasinusoidal B-cells were observed in both cases. These findings suggest that the intrasinusoidal B-cells may be plasma cell precursors.
Kelényi
G
G
Department of Pathology, University Medical School, Pécs, Hungary.
D001402:B-Lymphocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000473:pathology*