[Prognostic implications of the ploidy pattern of the nuclear DNA in hepatocellular carcinomas].
The nuclear DNA contents of paraffin-embedded specimens of 41 cases of a hepatocellular carcinoma have been measured by means of flow cytometry. Results have indicated that 25 cases (61%) were diploid and 16 cases (39%) were aneuploid. In the aneuploid cases, the serum AFP level was found to be higher and stage more advanced. We also found that patients with aneuploid tumors had a poorer prognosis than those with diploid tumors, this fact uncovered by means of a Cox's proportional hazard model. In conclusion, the ploidy pattern of the nuclear DNA may serve as a useful prognostic marker for a hepatocellular carcinoma.
Omagari
K
K
2nd Dept. of Int. Med., Nagasaki Univ. School of Med.
Imanishi
T
T
Morikawa
S
S
Nishihata
S
S
Kamiya
T
T
Hayashida
K
K
Tanioka
H
H
Murata
I
I
Makiyama
K
K
Ashihara
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000782:Aneuploidy; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate
D004273:DNA, Neoplasm