title: Direct angioplasty of the basilar artery in baboons.
abstract: The lower portion of the basilar artery is a site of significant disease, both aneurysmal and stenotic, but has been considered inaccessible via traditional surgical approaches. A baboon model was used to evaluate the feasibility of a direct surgical reconstruction via a transoral-transclival approach, utilizing temporary occlusion of the basilar artery. An arteriotomy was performed and either repaired primarily or a venous patch graft was sutured in place. All animals survived the surgery; one suffered fatal postoperative upper airway obstruction, but the other four were neurologically intact at the time of death. Patency at the site of repair was confirmed both angiographically and histologically. We conclude that temporary clamping in conjunction with direct reconstruction of the basilar artery is feasible in this primate model. Future studies will focus on further applications of this technique.
authors.affiliation: Department of Neurosurgery, Albert Einstein College of Medicine, New York, New York.
authors.forename: R A
authors.initials: RA
authors.lastname: de los Reyes
authors.forename: F H
authors.initials: FH
authors.lastname: Boehm
authors.forename: W
authors.initials: W
authors.lastname: Ehler
authors.forename: D
authors.initials: D
authors.lastname: Kennedy
authors.forename: F
authors.initials: F
authors.lastname: Shagets
authors.forename: W
authors.initials: W
authors.lastname: Woodruff
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: J I
authors.initials: JI
authors.lastname: Ausman
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000601:surgery*; D002545:Brain Ischemia / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D010215:Papio; D010865:Pilot Projects; D013536:Suture Techniques; D014715:Vertebrobasilar Insufficiency / Q000601:surgery*