The beta-adrenoceptor and endocrine abnormalities in juvenile depression.
Neuro-endocrine disturbances were determined in juvenile depressives and possible correlations with biochemical abnormalities investigated. It was established that, as in adult depressives, the young also showed a high incidence of cortisol non-suppression after dexamethasone administration. In addition, a positive correlation observed between lymphocyte beta-adrenoceptor maximal number of binding sites and basal cortisol levels stresses the involvement of the noradrenergic neurotransmission system.
Carstens
M E
ME
Department of Chemical Pathology, University of Stellenbosch, Parowvallei, CP.
Taljaard
J J
JJ
van Zyl
A M
AM
D000293:Adolescent; D001665:Binding Sites; D002648:Child; D003866:Depressive Disorder / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
D011943:Receptors, Adrenergic, beta; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone