Relation between plasma atrial natriuretic peptide (ANP) and glomerular ANP receptors in 5/6 nephrectomized rats.
Chronic renal failure (CRF) was induced in male wistar rats (Group I) by 5/6 nephrectomy and the sham-operated ones served as control (Group II). The results showed that in Group I, plasma atrial natriuretic peptide (ANP) levels increased progressively as the Scr was elevated. Plasma R-A rose simultaneously compared to the normal (P less than 0.001). At the 20th week after operation, urine volume and Na decreased significantly (P less than 0.05). The number of glomerular receptors decreased markedly at the 12th week (P less than 0.05) and 20th week (P less than 0.01). Our data suggest that in 5/6 nephrectomized rats, the elevation of plasma ANP level might be partly caused by the damage of glomerular ANP receptors, and the elevated plasma ANP could not play its role in diuresis, natriuresis, blood pressure depression and R-A inhibition as a result of the damage of kidney ANP receptors.
Jin
H
H
Department of Nephrology, China-Japan Friendship Hospital, Beijing.
Yuan
Z Y
ZY
Du
X H
XH
Su
G
G
Zhang
L
L
Wang
M X
MX
Dong
Y
Y
Liu
D X
DX
Zou
W Z
WZ
Wang
S L
SL
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001345:Autoradiography; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000737:chemistry; D008297:Male; D009392:Nephrectomy / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000032:analysis*
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor