Identification of prostaglandin E2 and leukotriene B4 in the synovial fluid of painful, dysfunctional temporomandibular joints.
It has been hypothesized that prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) should be present in the synovial fluid of inflamed, dysfunctional temporomandibular joints. An assay to identify PGE2 and LTB4 and platelet-activating factor (PAF) was used, and a strong correlation between the levels of these lipid mediators of pain and inflammation and an index of clinical joint pathology was found.
Quinn
J H
JH
Department of Oral and Maxillofacial Surgery, Louisiana State University Medical Center, New Orleans.
Bazan
N G
NG
D002358:Cartilage, Articular / Q000276:immunology; D015232:Dinoprostone / Q000032:analysis*; D005260:Female; D006801:Humans; D004204:Joint Dislocations / Q000276:immunology*; D007975:Leukotriene B4 / Q000032:analysis*; D008297:Male; D010972:Platelet Activating Factor / Q000032:analysis; D013582:Synovial Fluid / Q000276:immunology*; D013585:Synovitis / Q000276:immunology / Q000473:pathology; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000276:immunology*
D010972:Platelet Activating Factor; D007975:Leukotriene B4; D015232:Dinoprostone