title: A chromogranin A-derived peptide differentially regulates the secretion of calcitonin gene products.
abstract: We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)-derived peptides in a human lung tumor cell line. The amino-terminal peptide of CgA, CgA1-40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose-dependent manner. These studies demonstrate a differential effect of a CgA-derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.
authors.affiliation: Department of Medicine (Endocrine Division), University of California, La Jolla.
authors.forename: L J
authors.initials: LJ
authors.lastname: Deftos
authors.forename: R
authors.initials: R
authors.lastname: Hogue-Angeletti
authors.forename: C
authors.initials: C
authors.lastname: Chalberg
authors.forename: S
authors.initials: S
authors.lastname: Tu
mesh_terms: D002116:Calcitonin / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D053379:Chromogranin A; D002864:Chromogranins / Q000494:pharmacology*; D006801:Humans; D009363:Neoplasm Proteins / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; C067131:chromogranin A (1-40); D002116:Calcitonin; D010749:Phosphoprotein Phosphatases; D015740:Calcitonin Gene-Related Peptide