CMV encephalitis during ganciclovir therapy of CMV retinitis.
An AIDS patient with cytomegalovirus (CMV) retinitis was treated with ganciclovir (10 mg/kg) for four days followed by 5 mg/kg for 69 days. Clinically, CMV retinitis improved during therapy. Two weeks after induction of therapy, the patient became increasingly disoriented, and died 78 days after admission. Microscopically, a necrotizing encephalitis with characteristic cytomegalic cells with intranuclear inclusion bodies was observed. We conclude that ganciclovir therapy did not prevent development or progression of CMV encephalitis in the doses used.
Schwarz
T F
TF
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Germany.
Loeschke
K
K
Hanus
I
I
Jäger
G
G
Feiden
W
W
Stefani
F H
FH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D004660:Encephalitis / Q000150:complications / Q000517:prevention & control*; D015828:Eye Infections, Viral / Q000150:complications / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use*; D006716:Homosexuality; D006801:Humans; D008297:Male; D012173:Retinitis / Q000150:complications / Q000188:drug therapy*
D015774:Ganciclovir