title: Human megakaryocyte production: cell biology and clinical considerations.
abstract: Advances in the methodologic study of megakaryocytopoiesis are discussed, and their effect on the understanding of the production of platelets is included. This knowledge has led to a better understanding of disorders of megakaryocytopoiesis and platelet production. Specific diseases discussed are congenital megakaryocyte hypoplasia, acquired amegakaryocytic thrombocytopenic purpura, myeloproliferative disorders, reactive thrombocytosis, megakaryoblastic leukemia, and megakaryocyte and marrow fibrosis.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.
authors.forename: A M
authors.initials: AM
authors.lastname: Gewirtz
authors.forename: R
authors.initials: R
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000502:physiology; D001792:Blood Platelets / Q000166:cytology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D003115:Colony-Stimulating Factors / Q000502:physiology; D016207:Cytokines; D058851:GPI-Linked Proteins; D006410:Hematopoiesis; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000473:pathology; D008533:Megakaryocytes / Q000166:cytology*; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D009196:Myeloproliferative Disorders / Q000473:pathology; D011003:Ploidies; D055728:Primary Myelofibrosis / Q000473:pathology; D011506:Proteins / Q000502:physiology; D013921:Thrombocytopenia / Q000473:pathology
chemical_list: D001685:Biological Factors; D003115:Colony-Stimulating Factors; D016207:Cytokines; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D000090204:Mesothelin