title: GABA-receptors in peripheral tissues.
abstract: Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the gut, pancreatic islets and the urinary bladder. In some tissues, the pharmacology of GABA-induced actions is quite atypical and should be further explored with the newer ligands and modulators for GABAA- and GABAB-receptors.
authors.affiliation: Department of Anaesthesia and Intensive Care, University of Adelaide, South Australia.
authors.forename: J
authors.initials: J
authors.lastname: Ong
authors.forename: D I
authors.initials: DI
authors.lastname: Kerr
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000032:analysis; D004702:Endocrine Glands / Q000032:analysis / Q000502:physiology; D005704:Gallbladder / Q000032:analysis / Q000502:physiology; D008168:Lung / Q000032:analysis / Q000502:physiology; D009420:Nervous System / Q000032:analysis; D009424:Nervous System Physiological Phenomena; D011963:Receptors, GABA-A / Q000032:analysis / Q000502:physiology*; D001743:Urinary Bladder / Q000032:analysis / Q000502:physiology; D014566:Urogenital System / Q000032:analysis / Q000502:physiology
chemical_list: D011963:Receptors, GABA-A