Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines.
A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies revealed that compounds with small, lipophilic para substituents were good inhibitors of serotype 1B. Several compounds had good activity against four representative serotypes.
Kelley
J L
JL
Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
Linn
J A
JA
Selway
J W
JW
D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D011687:Purines; C063782:6-amino-2-chloropurine