Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1 (V) and NS2.
The sequence of the P (phosphoprotein) gene of mumps virus has been determined. It has two open reading frames, the first of which probably encodes the NS1 (or V) protein of mumps virus. Expression of the P protein requires the insertion of two non-templated residues to link the two ORFs in a process analogous to that observed in the P/V gene of simian virus type 5 to which mumps virus is closely related. Strain differences in the accuracy of insertion of non-templated G residues in the P/V gene transcripts have been described.
Elliott
G D
GD
School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland, U.K.
Yeo
R P
RP
Afzal
M A
MA
Simpson
E J
EJ
Curran
J A
JA
Rima
B K
BK
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D002642:Chick Embryo; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D005814:Genes, Viral; D014644:Genetic Variation; D008969:Molecular Sequence Data; D009109:Mumps virus / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014758:Viral Core Proteins / Q000235:genetics*; D017361:Viral Nonstructural Proteins
D004251:DNA Transposable Elements; D010750:Phosphoproteins; D012333:RNA, Messenger; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins