title: Increased genetic risk of hypertension in glomerulonephritis?
abstract: The present study was carried out to test the hypothesis that the familial risk of hypertension is elevated in individuals with glomerulonephritis. Sixty-three parents of 39 consecutive patients below the age of 50 years who were admitted with biopsy-confirmed primary glomerulonephritis (excluding familial glomerulonephritis) were examined. Of these parents, 57% had blood pressure greater than or equal to 160/95 mmHg and/or were taking antihypertensive medication (81% of hypertensives). In 138 parents of 87 controls (age- and sex-matched patients admitted to a surgical ward for trauma), hypertension was found in 32.6% (of whom 73% were on antihypertensive medication). Age, sex ratio and body mass index were comparable in both groups of parents. A similar proportion of parents of patients with glomerulonephritis (27%) and parents of controls (25%) had already died. There was no evidence of excess cardiovascular or renal mortality in either group of parents. Urinary abnormalities were found in a similar proportion of the parents of patients with glomerulonephritis (5%) and controls (8%). Although the effects of a shared environment are not formally excluded, the data are consistent with a possible increased genetic risk of hypertension in patients with primary chronic glomerulonephritis.
authors.affiliation: Department of Internal Medicine, Heidelberg, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: R
authors.initials: R
authors.lastname: Wegner
authors.forename: E
authors.initials: E
authors.lastname: Ritz
mesh_terms: D000367:Age Factors; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D005260:Female; D005820:Genetic Testing; D005921:Glomerulonephritis / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012744:Sex Ratio