[Activity of enzymes of the internal membrane of heart mitochondria and spectrum of blood fatty acids during myocardial necrosis reproduced after the stress].
An increase of proton permeability, creation of the possibility for the superoxide radical O2-. to escape and a decrease in the oxidation rate of acetyl-CoA due to the stress origin with such membrane-bound enzymes as succinate dehydrogenase and cytochrome oxidase remaining as active as they were, have been observed under the myocardial necroses reproduced after the endured stress in the internal mitochondrial membrane of the "non-ischemized" division of the left ventricle of the heart. Against a background of mitochondria denergization the content of non-esterified fatty acids in blood increases mainly as a result of the influx of non-esterified fatty acids of membrane origin.
Ryzhov
A A
AA
Medical Institute, Zaporizhzha.
Iakushev
V S
VS
D000818:Animals; D001386:Azides / Q000494:pharmacology; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood*; D007425:Intracellular Membranes / Q000201:enzymology*; D008929:Mitochondria, Heart / Q000201:enzymology*; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology* / Q000209:etiology; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001386:Azides; D005227:Fatty Acids; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D017301:Ca(2+) Mg(2+)-ATPase
Aktivnost' fermentov vnutrenneĭ membrany mitokhondriĭ serdtsa i spektr zhirnykh kislot krovi pri nekroze miokarda, vosproizvedennom posle stressa.