title: [The EPR spectra of the ribonucleotide reductase in the tumorous tissues and organs of tumor-bearing animals].
abstract: Ribonucleotide reductase activity (RRA) has been studied in various tumors and spleens of tumor-bearing animals using EPR technique and biochemical methods. The effect of a number of biologically active compounds on RRA has also been studied. RRA in tumor and spleen increases during tumor growth. Inhibitory effect of irradiation, hydroxyurea, nitrosomethylurea and activatory effect of 5-nitrofurans and nitroimidazole derivatives on RRA has been observed. Regulatory factors of RRA and DNA synthesis in vivo have been discussed.
authors.forename: M K
authors.initials: MK
authors.lastname: Pulatova
authors.forename: D E
authors.initials: DE
authors.lastname: Filatov
authors.forename: V L
authors.initials: VL
authors.lastname: Sharygin
authors.forename: L B
authors.initials: LB
authors.lastname: Gorbacheva
authors.forename: K V
authors.initials: KV
authors.lastname: Gudtsova
authors.forename: Z V
authors.initials: ZV
authors.lastname: Kuropteva
authors.forename: T T
authors.initials: TT
authors.lastname: Zhumabaeva
authors.forename: V I
authors.initials: VI
authors.lastname: Shamaev
authors.forename: D B
authors.initials: DB
authors.lastname: Korman
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007939:Leukemia L1210 / Q000201:enzymology*; D007941:Leukemia P388 / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012264:Ribonucleotide Reductases / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D012511:Sarcoma 37 / Q000201:enzymology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D013997:Time Factors
chemical_list: D012264:Ribonucleotide Reductases
vernacular_title: Spektry EPR ribonukleotidreduktazy v opukholevykh tkaniakh i organakh zhivotnykh-opukholenositeleĭ.