[The antiviral activity of amiksin and its effect on the interferon status in hepatitis in mice].
A single administration of amixin followed by oral infection with mouse hepatitis virus provided protection of 40%-50% animals for 72 hours and normalized the interferon status. In parallel with decreasing level of virus-induced endogenous interferon the interferon-inhibiting activity of lymphocytes of the infected animals increased and approached normal levels.
Grigorian
S S
SS
Ivanova
A M
AM
Ershov
F I
FI
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005449:Fluorenes / Q000627:therapeutic use*; D006524:Hepatitis, Viral, Animal / Q000097:blood / Q000188:drug therapy*; D007369:Interferon Inducers / Q000627:therapeutic use*; D007370:Interferon Type I / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D051379:Mice; D006517:Murine hepatitis virus; D013994:Tilorone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013997:Time Factors
D000998:Antiviral Agents; D005449:Fluorenes; D007369:Interferon Inducers; D007370:Interferon Type I; D007371:Interferon-gamma; D013994:Tilorone
Protivovirusnaia aktivnost' amiksina i ego vliianie na interferonovyĭ status pri gepatitie mysheĭ.