[Pyrimidine derivatives: their psychotropic properties and the molecular mechanisms of their central action].
The data on the neuro- and psychotropic effects of exo- and endogenous derivatives of pyrimidine are systematized. Uridine is characterized as an endogenous anxiolytic and antidepressant and thimidine as uridine antagonist. The given properties are probably determined by the binding of pyrimidine nucleosides to GABA, benzodiazepine and imipramine receptors as well as by their influence on the neuromediator systems. The involvement of the system of endogenous pyrimidines in the development of psychoneurological disturbances in man is shown.
Karkishchenko
N N
NN
Makliakov
Iu S
IuS
Stradomskiĭ
B V
BV
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008024:Ligands; D009497:Neurotic Disorders / Q000188:drug therapy; D011619:Psychotropic Drugs; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology
D008024:Ligands; D011619:Psychotropic Drugs; D011743:Pyrimidines; D017981:Receptors, Neurotransmitter
Proizvodnye pirimidina: psikhotropnye svoĭstva i molekuliarnye mekhanizmy tsentral'nogo deĭstviia.