Increase in the survival time of mice exposed to ionizing radiation by a new class of free radical scavengers.
N-acyl dehydroalanines react with and scavenge mainly superoxide radical (O-2.) and hydroxyl radical (HO.). The ortho-methoxyphenylacetyl dehydroalanine derivative, indexed as AD-20, protects mice against damage resulting from total body X-irradiation, as measured by the increase in their survival time. AD-20 increases the LD50 at 30 days from 6.1 to 7.3 Gy in animals exposed to a wide range of X-rays (6 to 10 Gy). The dose reduction factor (D R F) of AD-20 is 1.20. We postulate that such radioprotective effect may result from its free radical scavenging activity.
Buc-Calderon
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Unité de Biochimie Toxicologique et Cancérologique, Université Catholique de Louvain, Brussels, Belgium.
Roberfroid
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D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005609:Free Radicals; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents; D013481:Superoxides; D016019:Survival Analysis; D014965:X-Rays
D005609:Free Radicals; D011837:Radiation-Protective Agents; D013481:Superoxides; C053274:AD 20; D000409:Alanine