Biological activities of synthetic peptides of the sequence of human interferon-alpha.
Theoretical and experimental data were obtained indicating a possible role of the amino acid sequence 69-80 of HuIFN-alpha for antiviral activity of interferon. In this paper, synthetic peptides (penta-, octa- and dodecapeptides), representing the sequence region of positions 69-80 of the primary structure of HuIFN-alpha-2 were investigated with regard to their ability to inhibit the cytopathic effect of VSV on MDBK cells and on embryonic human fibroblasts. The peptides themselves exhibit only a very weak antiviral activity; however, it was found that these peptides even increase the antiviral activity of HuIFN-alpha-2.
Eichmann
E
E
Central Institute of Molecular Biology, Academy of Sciences of the GDR, Berlin-Buch.
Majarov
V A
VA
Kozhich
A T
AT
Noll
F
F
Zav'yalov
V P
VP
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011994:Recombinant Proteins; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development
D007370:Interferon Type I; D009842:Oligopeptides; D011994:Recombinant Proteins