title: Pseudorabies virus latency and reactivation in vaccinated swine.
abstract: Latency and reactivation of pseudorabies virus in swine was studied. Thirty-one pigs were assigned to 5 groups and were given 1 of 4 vaccines; 10 remained unvaccinated controls. All pigs were then challenge exposed with a sublethal dose of virulent pseudorabies virus. One hundred one days after challenge exposure, all pigs were treated with dexamethasone to reactivate the virus. Virus-positive tonsil and nasal mucus isolates were recovered from 29 of the 31 pigs over a 12-day period. Frequency and duration of virus-positivity were significantly (P less than 0.05) and consistently lower among vaccinated pigs than among the unvaccinated controls. It was concluded that vaccination before challenge exposure had little or no effect on the rate of establishment of virus latency, but that vaccination reduced shedding after subsequent reactivation of the virus.
authors.affiliation: Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011.
authors.forename: M A
authors.initials: MA
authors.lastname: Schoenbaum
authors.forename: G W
authors.initials: GW
authors.lastname: Beran
authors.forename: D P
authors.initials: DP
authors.lastname: Murphy
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D011558:Herpesvirus 1, Suid / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D009297:Nasal Mucosa / Q000382:microbiology; D009500:Neutralization Tests; D014066:Palatine Tonsil / Q000382:microbiology; D011897:Random Allocation; D013552:Swine; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D003907:Dexamethasone