Attenuated glomerular responses to atrial natriuretic factor in low-sodium rats is prevented by theophylline.
Atrial natriuretic factor administered in the large dose did not change glomerular filtration rate, but it was diuretic in low-sodium rats. In response to ANF, excretion of c-GMP was decreased in low-sodium rats in comparison with normal-sodium stimulated c-GMP accumulation in isolated glomeruli was more diminished in low- than normal sodium rats. These results indicate that attenuated glomerular responses to ANF in low-sodium rats might be due to increase of plasma Angiotensin II (Ang II) level, which increases intracellular Ca++ concentration. Theophylline can potentiate the renal response to ANF. We suggest that Ca(++)-activated c-GMP phosphodiesterase plays a major role in the regulation of intracellular accumulation of c-GMP in glomeruli exposed to ANF.
Angielski
S
S
Department of Clinical Biochemistry, Medical Academy, Gdansk, Poland.
Kuchta
G
G
Redlak
M
M
Szczepanska-Konkel
M
M
D000804:Angiotensin II / Q000097:blood / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D006152:Cyclic GMP / Q000097:blood / Q000378:metabolism / Q000652:urine; D005919:Glomerular Filtration Rate; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism* / Q000652:urine; D013806:Theophylline / Q000494:pharmacology*
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D012964:Sodium; D013806:Theophylline; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I; D006152:Cyclic GMP; D002118:Calcium