[The effect of various protein kinase inhibitors on the response of snail neurons to the intracellular injection of cAMP].
Drugs preventing cAMP interaction with regulatory subunit of cAMP-dependent protein kinase, tolbutamide and db-cAMP injected into neurons of Helix lucorum decreased the cell response to cAMP, but H-8-a potent inhibitor of this enzyme catalytic subunit did not produce such effect. It is suggested that the neuron electric response to cAMP injection is not caused by protein phosphorylation.
Liberman
E A
EA
Minina
S V
SV
Miakotina
O L
OL
Filatova
S V
SV
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D006372:Helix, Snails; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism
D007546:Isoquinolines; D047428:Protein Kinase Inhibitors; D003994:Bucladesine; C053177:N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide; D000242:Cyclic AMP; D011494:Protein Kinases
Vliianie razlichnykh ingibitorov proteinkinazy na éffekt vnutrikletochnoĭ in''ektsii tsAMF v neĭrony vinogradnoĭ ulitki.