Signet-ring cell carcinoid of the gallbladder.
A case of signet-ring cell carcinoid of the gallbladder is reported. The tumour diffusely infiltrated the gallbladder wall and extensively ulcerated the mucosa. Neoplastic nests were composed of numerous signet-ring cells mixed with clear endocrine cells. The latter expressed chromogranin A, gastrin and somatostatin and contained neurosecretory granules. The diagnostic problem of differentiating between signet-ring cell carcinomas and composite adenocarcinoma-carcinoid tumours is discussed.
Papotti
M
M
Department of Biomedical Sciences and Human Oncology, University of Turin, Italy.
Galliano
D
D
Monga
G
G
D000230:Adenocarcinoma / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron