title: Hypoglycemia of squirrel monkey neonates: implications for infant survival.
abstract: Neonatal deaths are a serious problem in breeding colonies of squirrel monkeys. Seriously ill neonates in our colony are always hypoglycemic on presentation. To determine normal glucose values for squirrel monkey infants of various ages, serum glucose determinations were done at 1, 3, 7, 10, 14 days and 1 month of age using a standard laboratory test for serum glucose. Glucose concentration increased from a low of 49 +/- 3 mg/dl (Mean +/- SEM) at 1 day (n = 21) to 109 +/- 4 mg/dl at 1 month of age (n = 17). Glucose values for 1, 3 and 7 day-old infants were significantly lower than 1 month-old infants (P less than .05). To provide a time-averaged indication of blood glucose, glycosylated hemoglobin (GHb) measurements were made at 1 day, 1 week, 2 weeks, 1 month, 2 months, 1 year of age and in adults (greater than 3 years of age). GHb values ranged from 2.6% +/- 0.1 for 1 day old infants (n = 13) to 4.0 +/- 0.2 for adults (n = 10) with a steady increase during the first 2 months of life. Animals 1 year of age and younger had significantly lower glycosylated hemoglobin than adults. These studies indicate that blood glucose concentration is significantly lower in squirrel monkey neonates than in older infants, juveniles and adults. Maternal rejection, trauma, and associated problems occur commonly in socially reared squirrel monkeys. The marginal hypoglycemic state of these infants places them at high risk for clinical hypoglycemia as a sequel to such perturbations.
authors.affiliation: Department of Comparative Medicine, College of Medicine, University of South Alabama, Mobile 36688.
authors.forename: A G
authors.initials: AG
authors.lastname: Brady
authors.forename: L E
authors.initials: LE
authors.lastname: Williams
authors.forename: C R
authors.initials: CR
authors.lastname: Abee
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D002427:Cebidae / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D007003:Hypoglycemia / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D008297:Male; D012453:Saimiri / Q000097:blood*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin