Immunohistochemical study of IOT-10 natural killer cells in brain metastases.
The presence of NK-cells in a series of 40 metastatic brain tumours has been studied by means of the monoclonal antibody IOT-10. There appeared IOT-10 NK-cells in all tumours studied, but in most cases these cells represented less than 10% of the tumour infiltrating lymphocytes (TIL). In the present series, the obtained data suggest that the number of NK-cells in brain metastases can be influenced by other factors than the mere quantity of TIL.
Vaquero
J
J
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Coca
S
S
Escandón
J
J
Magallón
R
R
Martínez
R
R
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000911:Antibodies, Monoclonal; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D002277:Carcinoma / Q000276:immunology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology / Q000473:pathology; D007694:Killer Cells, Natural / Q000473:pathology*; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal