Efficiency of phosphorylation of the cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity.
Kohlbrenner
W E
WE
Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, IL 60064-3500.
Carter
C D
CD
Fesik
S W
SW
Norbeck
D W
DW
Erickson
J
J
D000998:Antiviral Agents / Q000494:pharmacology*; D001711:Biotransformation; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D010766:Phosphorylation; D018139:Simplexvirus / Q000187:drug effects* / Q000201:enzymology; D013237:Stereoisomerism; D013937:Thymidine Kinase / Q000494:pharmacology*
D000998:Antiviral Agents; D006147:Guanine; C063638:lobucavir; D013937:Thymidine Kinase