Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.
Proton nuclear magnetic resonance spectroscopy was used to determine relative binding constants for several arsenical-antidote adducts. It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied.
O'Connor
R J
RJ
Biophysical Research Division, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
McGown
E L
EL
Dill
K
K
Hallowell
S F
SF
D000931:Antidotes / Q000737:chemistry*; D001152:Arsenicals / Q000737:chemistry*; D004112:Dimercaprol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents; D013237:Stereoisomerism; D004113:Succimer / Q000737:chemistry; D014494:Unithiol / Q000737:chemistry
D000931:Antidotes; D001152:Arsenicals; D012997:Solvents; D004112:Dimercaprol; C035965:lewisite; D014494:Unithiol; C053663:phenyldichloroarsine; D004113:Succimer