2,3-Bisphosphoglycerate, fructose, 2,6-bisphosphate and glucose 1,6-bisphosphate during maturation of reticulocytes with low 2,3-bisphosphoglycerate content.
In contrast to the species with erythrocytes of high 2,3-bisphosphoglycerate content, in the sheep the concentration of 2,3-bisphosphoglycerate decreases during maturation of reticulocytes. The decrease can be explained by the drop of the phosphofructokinase/pyruvate kinase and 2,3-bisphosphoglycerate synthase/2,3-bisphosphoglycerate phosphatase activity ratios that result from the decline of phosphofructokinase, pyruvate kinase, phosphoglycerate mutase and the bifunctional enzyme 2,3-bisphosphoglycerate synthase/phosphatase. The concentrations of fructose 2,6-bisphosphate and aldohexose 1,6-bisphosphates also decrease during sheep reticulocyte maturation in parallel to the 6-phosphofructo 2-kinase and the glucose 1,6-bisphosphate synthase activities.
Gallego
C
C
Departament de Ciències Fisiològiques Humanes i de la Nutrició, Facultat de Medicina, Universitat de Barcelona, Spain.
Carreras
J
J
D019794:2,3-Diphosphoglycerate; D000818:Animals; D001731:Bisphosphoglycerate Mutase / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood*; D005635:Fructosediphosphates / Q000097:blood*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000097:blood*; D009097:Multienzyme Complexes; D010732:Phosphofructokinase-1 / Q000097:blood; D010744:Phosphoric Monoester Hydrolases / Q000097:blood; D011770:Pyruvate Kinase / Q000097:blood; D012156:Reticulocytes / Q000378:metabolism*; D012756:Sheep
D004163:Diphosphoglyceric Acids; D005635:Fructosediphosphates; D005958:Glucosephosphates; D009097:Multienzyme Complexes; D019794:2,3-Diphosphoglycerate; D019298:Glucose-6-Phosphate; C027652:fructose 2,6-diphosphate; C016473:glucose-1,6-bisphosphate; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase; D010744:Phosphoric Monoester Hydrolases; C022364:phosphoglycerate phosphatase; D001731:Bisphosphoglycerate Mutase