title: Fibrosarcoma of the head and neck.
abstract: A review of 118 archival cases originally diagnosed as fibrosarcoma of the head and neck is presented. Sites of involvement were the sinonasal region, upper aerodigestive tract, skin, and soft tissues. Review of the pathologic specimens applying strict histopathologic criteria including immunohistochemical techniques reclassified many of the tumors as malignant fibrous histiocytoma, monophasic synovial sarcoma-like neoplasm, or dermatofibrosarcoma protuberans. Improved clinical outcome correlated significantly with lesser tumor size, lower histologic grade, and negative surgical margins. Location in the skin or soft tissue tended to convey improved survival, although not to a level of statistical significance.
authors.affiliation: Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: R
authors.initials: R
authors.lastname: Frankenthaler
authors.forename: A G
authors.initials: AG
authors.lastname: Ayala
authors.forename: R W
authors.initials: RW
authors.lastname: Hartwick
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D000328:Adult; D005260:Female; D005354:Fibrosarcoma / Q000453:epidemiology / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D015993:Life Tables; D008297:Male; D011379:Prognosis; D016019:Survival Analysis; D013781:Texas / Q000453:epidemiology