title: Possible role of H1 histone in the differentiation of mouse erythroleukemia cells.
abstract: Serum-starved mouse erythroleukemia cells, stationary phase cells or cells cultured in dibutyryl cAMP (1 mM) can be induced to differentiate by addition of 20% fetal calf serum plus cycloheximide. Culturing unstarved log phase cells in 20% fetal calf serum plus low levels of cycloheximide and histone H1 also causes a significant level of differentiation. These same concentrations of cycloheximide and H1 histone employed separately with 20% fetal calf serum do not induce differentiation. The role these procedures may have in causing an accumulation of histone H1 and cell differentiation is discussed.
authors.affiliation: Department of Biological Sciences, State University of New York, Buffalo 14260.
authors.forename: R A
authors.initials: RA
authors.lastname: Flickinger
authors.forename: E
authors.initials: E
authors.lastname: Brooks
authors.forename: P
authors.initials: P
authors.lastname: Choi
authors.forename: M
authors.initials: M
authors.lastname: Morlock
authors.forename: B
authors.initials: B
authors.lastname: Parker
authors.forename: J
authors.initials: J
authors.lastname: Snider
mesh_terms: D000818:Animals; D001769:Blood; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D003470:Culture Media; D003513:Cycloheximide / Q000494:pharmacology; D006657:Histones / Q000378:metabolism*; D004915:Leukemia, Erythroblastic, Acute; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D003470:Culture Media; D006657:Histones; D003994:Bucladesine; D003513:Cycloheximide