title: Lipid involvement in protein translocation in Escherichia coli.
abstract: Signal peptides play an essential role in protein translocation. This review summarizes the current knowledge of the structure of signal peptides and signal peptide-lipid interactions and addresses the possibility that signal peptide-lipid interactions initiate membrane translocation of precursor proteins. A new model for protein translocation in Escherichia coli is proposed, which includes as central features conformational changes of the signal peptide and signal-peptide-induced local changes in membrane organization (non-bilayer lipids).
authors.affiliation: Centre for Biomembranes and Lipid Enzymology, University of Utrecht, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: de Vrije
authors.forename: A M
authors.initials: AM
authors.lastname: Batenburg
authors.forename: J A
authors.initials: JA
authors.lastname: Killian
authors.forename: B
authors.initials: B
authors.lastname: de Kruijff
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D004926:Escherichia coli / Q000378:metabolism*; D008563:Membrane Lipids / Q000502:physiology*; D008969:Molecular Sequence Data; D021382:Protein Sorting Signals / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D008563:Membrane Lipids; D021382:Protein Sorting Signals