title: Increased concentrations of a circulating sodium pump inhibitor in essential hypertension and uraemia and its partial purification from haemofiltrate.
abstract: Patients with essential hypertension have 3.2 fold and patients with chronic uraemia 11.7 fold higher serum concentrations of endogenous digitalis-like activity than normotensives (76.3 +/- 9.3 nM). Upon haemodialysis this serum activity drops to almost normal values. A low molecular factor could be partially purified from 4000 l haemofiltrate.
authors.affiliation: Institute of Biochemistry and Endocrinology, Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Wenzel
authors.forename: E
authors.initials: E
authors.lastname: Heidrich
authors.forename: U
authors.initials: U
authors.lastname: Kirch
authors.forename: K
authors.initials: K
authors.lastname: Moreth-Wolfrat
authors.forename: V
authors.initials: V
authors.lastname: Wizemann
authors.forename: W
authors.initials: W
authors.lastname: Schoner
mesh_terms: D000368:Aged; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002298:Cardenolides; D002845:Chromatography; D002908:Chronic Disease; D004077:Digoxin; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012503:Saponins; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014511:Uremia / Q000097:blood*
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase