Organ-specific distribution of isozymes of 5'-nucleotide phosphodiesterase in mouse.
1. The distribution of isozymes of 5'-nucleotide phosphodiesterase (E.C.3.1.4.1) was examined in various organs of mouse, including liver, spleen, pancreas, heart, lung, kidney, brain and blood. 2. Five isozymes were identified and designated as isozymes I through V. 3. These isozymes are distributed unevenly with respect to the various organs and clear differences were observed in the patterns of distribution among the organs examined. 4. The level of these isozymes was compared in serum of neonate and adult mice, and a higher level of isozyme I and a lower level of isozyme IV were found in neonates compared to adults. 5. These results suggest that each isozyme has different functional roles in individual organs and that these isozymes may be involved in proliferation and development of cells.
Gross
S C
SC
Department of Medical Microbiology/Immunology, Southern Illinois University School of Medicine, Springfield 62708.
Watabe
M
M
Goodarzi
G
G
Darabi
A
A
Watabe
K
K
D000818:Animals; D000831:Animals, Newborn; D015415:Biomarkers; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011247:Pregnancy; D014018:Tissue Distribution
D015415:Biomarkers; D007527:Isoenzymes; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I