Parainfluenza-3 induced hyperreactivity of the guinea pig trachea coincides with an increased number of bronchoalveolar cells.
Guinea pigs were inoculated intra-tracheally with bovine parainfluenza type 3 virus (PI-3) to investigate whether airway hyperreactivity was associated with an increase in the number of broncho-alveolar cells. Two days after saline or PI-3 inoculation no difference in histamine reactivity of the isolated tracheal spirals was observed. The number of broncho-alveolar cells was also not changed. However, 4 days after PI-3 inoculation the histamine-induced contraction of the tracheal spirals was increased by 45% and the number of inflammatory cells in the airways by 150% as compared with the control group. In conclusion, PI-3 infection of the guinea pig respiratory airways induces tracheal hyperreactivity which is associated with an increase in broncho-alveolar cells.
Folkerts
G
G
State University of Utrecht, Faculty of Pharmacy, Department of Pharmacology, The Netherlands.
Janssen
M
M
Nijkamp
F P
FP
D000818:Animals; D001980:Bronchi / Q000166:cytology / Q000503:physiopathology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010224:Parainfluenza Virus 3, Human; D018184:Paramyxoviridae Infections / Q000503:physiopathology*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000503:physiopathology*; D007507:Therapeutic Irrigation; D014132:Trachea / Q000166:cytology / Q000503:physiopathology*
D006632:Histamine