Erythema induratum of Bazin as a type of tuberculid.
We report three cases of patients with erythema induratum of Bazin who showed extreme tuberculin hypersensitivity reactions and a good therapeutic response to isoniazid. In the first patient satellite lesions with epithelioid granuloma formation developed 3 weeks after injection of purified protein derivative. In the second patient a high fever developed 1 day after injection of purified protein derivative, and the third patient blistered at the injection site; the histopathologic pattern was similar to erythema multiforme. Immunohistologic study of the epithelioid granulomas demonstrated a predominance of Leu-1--bearing, Leu-3a--bearing, and human lymphocyte antigen-DR-expressing cells. We conclude that erythema induratum of Bazin represents a tuberculid caused by heightened delayed-type hypersensitivity to components of tubercle bacilli released from latent foci of infection.
Kuramoto
Y
Y
Department of Dermatology, Tohoku University School of Medicine, Japan.
Aiba
S
S
Tagami
H
H
D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D004891:Erythema Induratum / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000098:blood supply / Q000473:pathology; D014382:Tuberculosis, Cutaneous / Q000473:pathology*
D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D007538:Isoniazid