Activation of class I major histocompatibility complex gene expression by hepatitis B virus.
Normal hepatocytes express very few class I major histocompatibility complex (MHC I) molecules, but MHC I expression is elevated in hepatitis B virus (HBV) infection. We report here that hepatoblastoma cells with replicating HBV genomes express three- to fourfold-higher levels of MHC I protein and mRNA than do parent cells without HBV DNA. Transient transfection assays demonstrated that the HBV X protein trans activated transcription from an MHC I promoter and allowed identification of cis elements important for trans activation.
Zhou
D X
DX
Department of Pathology, University of California School of Medicine, San Francisco 94143-0506.
Taraboulos
A
A
Ou
J H
JH
Yen
T S
TS
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms; D008969:Molecular Sequence Data; D015533:Transcriptional Activation
D015395:Histocompatibility Antigens Class I; D015088:2',5'-Oligoadenylate Synthetase