A new circulating hypertensive factor in the plasma of essential hypertensive subjects.
The pressor responses to dialyzed plasma extracts from normotensive (n = 15) and essential hypertensive (n = 14) human subjects were evaluated in anesthetized Sprague-Dawley rats. Hypertensive but not normotensive plasma raised mean arterial pressure (23.6 +/- 3.6 versus -0.5 +/- 2.5 mmHg, P less than 0.0001), and this effect was correlated significantly with its ability to stimulate 45Ca uptake in rat tail artery vascular smooth muscle (r = 0.883, P less than 0.002). These data suggest a humoral contribution to the pathophysiology of essential hypertension in at least some individuals. The time-course and molecular weight distribution of the dialyzed plasma suggest that this effect is not due to known vasopressor substances, but to a factor we tentatively term plasma hypertensive factor.
Lewanczuk
R Z
RZ
Department of Physiology, University of Alberta, Edmonton, Canada.
Resnick
L M
LM
Blumenfeld
J D
JD
Laragh
J H
JH
Pang
P K
PK
D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014556:Urine / Q000032:analysis
D002118:Calcium