Activity of angiotensin I converting enzyme in sarcoidosis, atopic bronchial asthma and acute bronchitis.
The lungs have an important role in the synthesis of ACE. In BAL fluid and serum the ACE activity was determined in 18 patients with sarcoidosis (11 with high intensity and 7 with low intensity alveolitis), 25 patients with atopic bronchial asthma and 17 with acute bronchitis. The activity of ACE was examined by a reagent set produced by Boehringer Mannheim Biochemica Test-Combination ACE cat. no. 789 011. In the high intensity alveolitis group of sarcoidosis patients the ACE activity was significantly increased in BAL fluid and serum in comparison to other observed patients. On the other hand, in patients with atopic bronchial asthma the ACE activity was also increased in comparison to acute bronchitis and referred norms. These findings suggest a role of atopic processes or administered therapy in ACE secretion in the airways.
Plusa
T
T
Department of Internal Medicine, Central Clinical Hospital, Military Medical Academy, Warsaw, Poland.
Chcialowski
A
A
Piechota
W
W
Pirozyński
M
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000201:enzymology*; D001991:Bronchitis / Q000201:enzymology*; D001992:Bronchoalveolar Lavage Fluid / Q000201:enzymology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D012507:Sarcoidosis / Q000201:enzymology*
D007703:Peptidyl-Dipeptidase A