title: [17 beta hydroxysteroid dehydrogenase and creatine phosphokinase activities and the levels of sex hormones and their receptors in the uterus of patients with fibromyoma or endocrine sterility].
abstract: Examination of endometrial and myometrial activity of steroidogenic enzyme markers, 17 beta-hydroxy steroid dehydrogenase (17 beta-HOSD) and creatine phosphokinase (CP), in women with fibromyoma or endocrine infertility has demonstrated that endometrial 17 beta-HOSD activity corresponded to ovarian progesterone secretion rates but did not correlate with cytosolic progesterone secretion rates but did not correlate with cytosolic progesterone receptor levels. The magnitude of uterine effects of endogenous progesterone in the patients with endocrine infertility and fibromyoma may be inferred from (1) hormone ability to induce 17 beta-HOSD, and (2) ability to reduce cytosolic progesterone receptor levels. Neither endometrial nor myometrial CP represents a "pure" marker of estrogenic influence.
authors.forename: N A
authors.initials: NA
authors.lastname: Arutiunian
authors.forename: O N
authors.initials: ON
authors.lastname: Savchenko
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000328:Adult; D003402:Creatine Kinase / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000378:metabolism*; D007889:Leiomyoma / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
chemical_list: D011980:Receptors, Progesterone; D011374:Progesterone; D015067:17-Hydroxysteroid Dehydrogenases; C032690:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); D003402:Creatine Kinase
vernacular_title: Aktivnost' 17beta-gidroksisteroiddegidrogenazy, kreatinfosfokinazy, soderzhanie polovykh steroidov i ikh retseptorov v matke u bol'nykh s fibromiomoĭ ili éndokrinnym besplodiem.