Phencyclidine binding to striatal cocaine receptors.
PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 microM) is less than its affinity at its own receptor (Ki about 0.12 microM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP.
Kuhar
M J
MJ
Neuroscience Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Boja
J W
JW
Cone
E J
EJ
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002352:Carrier Proteins; D003042:Cocaine / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008454:Mazindol / Q000378:metabolism; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism
D002352:Carrier Proteins; D011955:Receptors, Drug; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C061445:cocaine receptor; D008454:Mazindol; D003042:Cocaine; D010622:Phencyclidine; D004298:Dopamine