title: Evidence that bremazocine prevents urine retention induced by intraspinal cord injection of colchicine in rats.
abstract: Intra-spinal cord injection of colchicine (2.5-5 micrograms/rat) produced an inhibition of reflex micturition leading to voiding suppression, bladder hypertrophy and overflow incontinence. Intraperitoneal administration of bremazocine, a kappa-receptor agonist with antagonistic properties for mu- and delta-receptors minimized the colchicine induced effects. The selective kappa-receptors agonist, U-69593, had little effect, while eledoisin or naloxone administration worsened rather than counteracted urine retention.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Modena University, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zanoli
authors.forename: M
authors.initials: M
authors.lastname: Baraldi
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D044482:Benzeneacetamides; D001575:Benzomorphans / Q000494:pharmacology*; D003078:Colchicine / Q000008:administration & dosage / Q000494:pharmacology*; D004600:Eledoisin / Q000494:pharmacology; D006984:Hypertrophy; D007278:Injections, Spinal; D009270:Naloxone / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D014554:Urination / Q000187:drug effects*
chemical_list: D000700:Analgesics; D044482:Benzeneacetamides; D001575:Benzomorphans; D011759:Pyrrolidines; D011957:Receptors, Opioid; D009270:Naloxone; D004600:Eledoisin; C027248:bremazocine; C045444:U 69593; D003078:Colchicine