[The enhanced relative intensity of cAMP-dependent protein phosphorylation in stomach tumors].
The activity of cAMP-dependent histone kinases (HK) and cAMP-independent casein kinases (CK) as well as cAMP level were assessed in gastric mucosa affected by various forms of gastritis as well as in gastric tumor and adjacent normal tissue. CK activity was higher whereas that of HK and cAMP level were lower in tumor and at a distance of 5-20 cm from its edge as compared to gastritis. CK/HK cAMP ratio in adenocarcinoma was 6 times that in normal tissue and 2-2.5 times that in gastritis. The data obtained and those published earlier suggest the relative increase in cAMP-independent protein phosphorylation with respect to its cAMP-dependent counterpart to be characteristic of human tumors.
Grozdova
I D
ID
Prokhorova
L V
LV
Mamaeva
E G
EG
Krekhnov
B V
BV
Sveshnikova
E V
EV
Ivashkin
V T
VT
Vasil'ev
V Iu
VIu
Severin
E S
ES
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005757:Gastritis, Atrophic / Q000378:metabolism; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D010766:Phosphorylation; D006656:Protamine Kinase / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D009363:Neoplasm Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D006656:Protamine Kinase; D017346:Protein Serine-Threonine Kinases
Uvelichenie otnositel'noĭ intensivnosti cAMP-nezavisimogo fosforilirovaniia belkov v opukholiakh zheludka.