title: Cystic fibrosis. IV. Structural analysis of a chloroform soluble compound isolated from gastric juice.
abstract: Cystic fibrosis (CF) is the most common autosomal disorder yet its cause is unknown. During an investigation of chloroform soluble fraction compounds of samples of gastric secretions from children with CF, a new substance was isolated. The new compound is concerned in alteration of membrane phospholipid composition, and changes in the activity of the enzyme transferring long-chain acyl moieties. Its structure is investigated, evaluated and discussed in relation to CF.
authors.affiliation: Department of Biophysics, University of Lódź, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Witas
authors.forename: K
authors.initials: K
authors.lastname: Bruzik
mesh_terms: D000468:Alkalies; D002247:Carbon Isotopes; D002648:Child; D002725:Chloroform; D002855:Chromatography, Thin Layer; D003550:Cystic Fibrosis / Q000378:metabolism*; D004051:Diethylhexyl Phthalate / Q000737:chemistry / Q000302:isolation & purification*; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D006851:Hydrochloric Acid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000432:Methanol; D015394:Molecular Structure; D011522:Protons
chemical_list: D000468:Alkalies; D002247:Carbon Isotopes; D011522:Protons; D002725:Chloroform; D004051:Diethylhexyl Phthalate; D006851:Hydrochloric Acid; D000432:Methanol