NMDA and kainic acid receptors have a complementary distribution to AMPA receptors in the human cerebellum.
The distributions of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were concentrated in the cerebellar molecular layer while NMDA and KA receptors were concentrated in the granular layer.
Jansen
K L
KL
Department of Anatomy, University of Auckland Medical School, New Zealand.
Faull
R L
RL
Dragunow
M
M
D000368:Aged; D001345:Autoradiography; D002531:Cerebellum / Q000737:chemistry*; D005260:Female; D006801:Humans; D007051:Ibotenic Acid / Q000031:analogs & derivatives; D007608:Kainic Acid; D008297:Male; D008875:Middle Aged; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis*; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D007051:Ibotenic Acid; D007608:Kainic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid