[Cardiovascular effect mediated by phencyclidine receptor in central nervous system].
In recent years, more and more attention has been paid to the studies about the cardiovascular function of phencyclidine (PCP) receptor, but very little about the cardiovascular function of central PCP receptor. In this study, we observed the effects of PCP on the blood pressure (BP) and heart rate (HR) by injecting the agonist or antagonist of PCP receptor into cerebral ventricle (icv) or spinal subarachnoid space (ith), to find out the cardiovascular function of central PCP receptor. It was found that icv PCP (250 nmol) elicited a slow and long lasting hypotension or fast and long lasting bradycardia. ith PCP elicited sharp hypotension and bradycardia immediately, with dose-dependent response. The hypotension and bradycardia of ith PCP (150 nmol) were significantly antagonized by ith 15 nmol dextrorphan. TCP, an agonist of PCP receptor, also elicited sharp hypotension and bradycardia immediately. However, subcutaneous injection (sc) of PCP (10 mg/kg) elicited hypertension and had no effect on HR. The results mentioned above indicate that central PCP receptors have the inhibitory effect on cardiovascular system. The cardiovascular effect of sc PCP may be the effect of combination of central and peripheral PCP receptors.
Yu
C X
CX
Department of Neurobiology, Shanghai Medical University.
Xu
S F
SF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D008845:Microinjections; D010622:Phencyclidine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D017478:Receptors, Phencyclidine; D013116:Spinal Cord / Q000502:physiology
D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D010622:Phencyclidine