title: Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34.
abstract: CD28 is a cell surface molecule present on most peripheral T cells which has been implied in the amplification of the T-cell response in vitro. Using in situ hybridization on human prometaphase cells, we have found that the human CD28 gene maps to chromosome 2 at bands q33-q34, as shown previously for the CTLA-4 gene. CD28 and CTLA-4 are both members of the Ig superfamily, where they define a subgroup of membrane-bound single V domains. Their chromosomal proximity and their close structural relationship suggest that these two genes could be the result of the duplication of a common evolutionary precursor and may share some functional properties.
authors.affiliation: INSERM U. 119, Institut Paoli-Calmettes, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Lafage-Pochitaloff
authors.forename: R
authors.initials: R
authors.lastname: Costello
authors.forename: D
authors.initials: D
authors.lastname: Couez
authors.forename: J
authors.initials: J
authors.lastname: Simonetti
authors.forename: P
authors.initials: P
authors.lastname: Mannoni
authors.forename: C
authors.initials: C
authors.lastname: Mawas
authors.forename: D
authors.initials: D
authors.lastname: Olive
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D001345:Autoradiography; D018106:CD28 Antigens; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000032:analysis*; D006801:Humans; D008297:Male; D005810:Multigene Family; D009693:Nucleic Acid Hybridization
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens