Bladder contracture following intravesical doxorubicin therapy: case report and a review of the literature.
Intravesical doxorubicin rarely has been implicated as a cause of bladder contracture. We present a case of severe bladder contracture, documented radiographically and urodynamically after 8 weekly intravesical instillations of doxorubicin. The patient subsequently underwent cystectomy because of voiding dysfunction and the specimen demonstrated marked fibrosis in the bladder wall. We postulate that a benign, recurrent bladder ulceration during doxorubicin therapy may have potentiated the fibrotic response in the bladder to the doxorubicin. Objective monitoring of bladder capacity should be considered in patients treated with intravesical chemotherapy.
Dmochowski
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University of Texas Medical School, Houston.
Rudy
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DC
D000283:Administration, Intravesical; D003286:Contracture / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology
D004317:Doxorubicin