title: Coffee consumption and serum lipids: a randomized, crossover clinical trial.
abstract: OBJECTIVE
  The purpose of this study was to determine the effect of consuming three or more cups of filter-brewed coffee per day on levels of serum lipids.
  
  
  METHODS
  A prospective, randomized crossover clinical trial was performed. Twenty-one healthy white male subjects completed the trial, and consumed an average of 3.6 cups of coffee a day. Data were evaluated by analysis of variance for repeated measures and t-test for paired means.
  
  
  RESULTS
  No effect of coffee consumption on serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or apolipoprotein B was found. Diet, creamer use, and cigarette use as well as group assignment and time factors were controlled for in the analysis.
  
  
  CONCLUSIONS
  We found no effect of moderate consumption of filter-brewed coffee on serum levels of atherogenic lipids. This study supports previous work that filtered coffee has no adverse effect on serum lipids. This has far-reaching implications given the widespread use of coffee and the current concern over coronary risk factors.
authors.affiliation: Department of Medicine, University of Tennessee, Memphis 38163.
authors.forename: P C
authors.initials: PC
authors.lastname: Rosmarin
authors.forename: W B
authors.initials: WB
authors.lastname: Applegate
authors.forename: G W
authors.initials: GW
authors.lastname: Somes
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003069:Coffee / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood*
chemical_list: D003069:Coffee; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol