Cytokine and non-cytokine differentiating agents for myeloid leukemic cells.
Existing data suggest that normal maturation can sometimes be re-established in leukemia. A number of differentiation-inducing substances have been reported; these include retinoic acid, vitamin D3 and cytokines such as differentiation-inducing factor, tumor necrosis factor and lymphotoxin. Different agents obviously act by separate mechanisms to provide terminal maturation.
Olsson
I
I
Department of Medicine, Lund Hospital, Sweden.
Gullberg
U
U
Lantz
M
M
D001665:Binding Sites; D002454:Cell Differentiation / Q000187:drug effects; D002762:Cholecalciferol / Q000494:pharmacology; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism / Q000473:pathology*; D008222:Lymphokines / Q000378:metabolism / Q000494:pharmacology*; D008233:Lymphotoxin-alpha / Q000378:metabolism / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000494:pharmacology
D008222:Lymphokines; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; C050979:monocyte-macrophage differentiation factor; D002762:Cholecalciferol; D014212:Tretinoin