Microsomal lipid peroxidation and oxy-radicals formation are induced by insoluble iron-containing minerals.
Lipid peroxidation, measured by malondialdehyde formation is induced in rat liver microsomes by insoluble iron-containing minerals (pyrite, magnetite, nemalite and an iron ore, minette de Lorraine) which are generally found either in iron mines or as contaminants of asbestos fibers. In spin-trapping studies using DMPO as a spin trap those minerals are also found to catalyze the oxidation of formate to carboxylate radicals by oxygen, via the formation of hydroxyl radicals. The two processes are mainly due to the presence of redox active iron at the surface of the solid particles and thus are greatly inhibited by desferrioxamine, a strong iron chelator. However, these reactions are not correlated.
Fontecave
M
M
LEDSS, Université Joseph Fourier, Domaine Universitaire de Saint-Martin d'Hères, Grenoble, France.
Jaouen
M
M
Mansuy
D
D
Costa
D
D
Zalma
R
R
Pezerat
H
H
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002254:Carbonates / Q000494:pharmacology*; D002374:Catalase / Q000494:pharmacology; D003497:Cyclic N-Oxides; D003676:Deferoxamine / Q000494:pharmacology; D005290:Ferric Compounds / Q000494:pharmacology*; D052203:Ferrosoferric Oxide; D016166:Free Radical Scavengers; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D008903:Minerals / Q000494:pharmacology*; D010087:Oxides / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012824:Silicic Acid / Q000494:pharmacology*; D013113:Spin Labels; D013440:Sulfides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology
D002254:Carbonates; D003497:Cyclic N-Oxides; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D006878:Hydroxides; D008903:Minerals; D010087:Oxides; D013113:Spin Labels; D013440:Sulfides; C011342:pyrite; D012824:Silicic Acid; D002245:Carbon Dioxide; C041069:carboxyl radical; C000499:ferric oxide; D017665:Hydroxyl Radical; D008315:Malondialdehyde; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D003676:Deferoxamine; D010100:Oxygen; D052203:Ferrosoferric Oxide