title: Effects of isosorbide dinitrate on the pattern of arterial blood flow in healthy human subjects.
abstract: 1. Blood velocity measurements have been made in the superficial femoral artery, 10 cm downstream of the common femoral artery bifurcation, in healthy human subjects, using a multi-channel Doppler ultrasound device. 2. In a randomized double-blind protocol, the effects of isosorbide dinitrate were examined during a 2 h period. 3. The changes induced by isosorbide dinitrate include: (i) an increase in the width of the artery and a reduction in brachial arterial blood pressure, implying relaxation of arterial smooth muscle; (ii) an increase in reverse flow and a decrease in time-averaged mean velocity associated with a relatively small decrease of the velocity excursion during the cardiac cycle, implying an increase in flow pulsatility; and (iii) an alteration of the flow pattern both in the core and near the vessel walls.
authors.affiliation: Physiological Flow Studies Unit, Imperial College, London.
authors.forename: C G
authors.initials: CG
authors.lastname: Caro
authors.forename: P J
authors.initials: PJ
authors.lastname: Fish
authors.forename: D E
authors.initials: DE
authors.lastname: Goss
authors.forename: J
authors.initials: J
authors.lastname: Halls
authors.forename: M J
authors.initials: MJ
authors.lastname: Lever
authors.forename: K H
authors.initials: KH
authors.lastname: Parker
authors.forename: A S
authors.initials: AS
authors.lastname: Clear
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects*; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D007548:Isosorbide Dinitrate