title: Time course of alpha 2-adrenoceptor desensitization induced by adrenaline infusion in man.
abstract: After a rapid increase in infusion rate of adrenaline to elevate the initial heart rate by more than 15%, a continuous infusion was sustained in order to maintain elevated adrenaline plasma levels. At the end of the first phase of the experiment, the thrombocyte alpha 2-adrenoceptor number (determined by radioligand binding) was significantly lowered. After the second part of the experiment, a further significant decrease in the density of binding sites was observed, while elevated adrenaline plasma levels were kept constant. The decrease in the number of binding sites was accompanied by a slight increase in affinity of the radioligand. Serum potassium concentration significantly decreased during the experiment, while other serum electrolytes showed no significant alterations.
authors.affiliation: Center of Internal Medicine, Justus Liebig University, Giessen, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Lübbecke
authors.forename: S
authors.initials: S
authors.lastname: Zschätzsch
authors.forename: V
authors.initials: V
authors.lastname: Mitrovic
authors.forename: H
authors.initials: H
authors.lastname: Husseini
authors.forename: G
authors.initials: G
authors.lastname: Schütterle
authors.forename: V
authors.initials: V
authors.lastname: Wizemann
mesh_terms: D000328:Adult; D001665:Binding Sites / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011188:Potassium / Q000097:blood; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D015016:Yohimbine / Q000378:metabolism
chemical_list: D002395:Catecholamines; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D011188:Potassium; D004837:Epinephrine