title: Studies on high grade cerebral gliomas.
abstract: A brief review of attempts in the United Kingdom to improve the results of treatment of high grade (grade 3, 4) supra-tentorial astrocytomas is presented. The radiosensitizer misonidazole failed to improve the results of post-surgical radiotherapy, however, multivariate analysis of data from these patients has provided a prognostic index of use in defining good and poor prognosis patients. An overview study of adjuvant nitrosourea therapy trials has shown a small significant advantage for the chemotherapy. A study of chemosensitization by benznidazole of CCNU treatment of patients in relapse failed to demonstrate any effect.
authors.affiliation: University Department, Addenbrookes Hospital, Cambridge, U.K.
authors.forename: N M
authors.initials: NM
authors.lastname: Bleehen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000628:therapy*; D006801:Humans; D011379:Prognosis; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents