Role of endotoxin and interleukin-1 in modulating ACTH, LH and sex steroid secretion.
We have shown that the endotoxin LPS acted both at the level of the brain and the gonads to stimulate the hypothalamic-pituitary-adrenal, and inhibit the hypothalamic-pituitary-gonadal, axis. Exogenously administered IL-1 mimics most of the effects of LPS on pituitary activity. In addition, antibodies against IL-1 receptors can interfere with LPS-induced ACTH secretion. These results suggest that at least part of the ability of LPS to alter endocrine functions appears to depend upon endogenous interleukin-1.
Rivier
C
C
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006066:Gonads / Q000187:drug effects / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood; D000521:alpha-MSH / Q000097:blood
D004731:Endotoxins; D012739:Gonadal Steroid Hormones; D007375:Interleukin-1; D013739:Testosterone; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone