Effect of physostigmine on plasma angiotensin converting enzyme activity in rat.
The effect of physostigmine on plasma angiotensin converting enzyme activity in rat was studied. Following administration of the drug (0.3 mg/kg), plasma angiotensin activity fell significantly at 45 min (P less than 0.05) and continued to decline during the course of the experiment. These data demonstrate that physostigmine inhibits plasma angiotensin converting enzyme activity in rat.
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Department of Pharmacology, Howard University, Washington, D.C. 20059.
Taylor
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010830:Physostigmine; D007703:Peptidyl-Dipeptidase A