title: Sequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-src.
abstract: We show that Schmidt-Ruppin D pp60v-src kinase activity is reduced by a mutation previously shown to be associated with Schmidt-Ruppin A pp60v-src temperature sensitivity and that its reduced transforming activity is associated with a conformational change in the SH3 region. The evolutionary relationship of seven v-src strains was studied by using parsimony analysis.
authors.affiliation: Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Mazzu
authors.forename: D
authors.initials: D
authors.lastname: Mahan
authors.forename: D
authors.initials: D
authors.lastname: Shalloway
mesh_terms: D000595:Amino Acid Sequence; D001354:Avian Leukosis Virus / Q000145:classification / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D015688:Oncogene Protein pp60(v-src) / Q000235:genetics*; D010449:Peptide Mapping; D011110:Polymorphism, Genetic; D011505:Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)