title: Lymphatic vessels and Kurloff cells in the thymus of estradiol-treated guinea pigs.
abstract: Male guinea pigs were given a single subcutaneous injection of estradiol, which induces formation of Kurloff cells, and serial sections of thymus were examined after 10, 12, 15 and 21 days. Kurloff cells were found in large numbers in lymphatic vessels, both outside the thymus, in the interlobular tissue, at the cortical surface and inside the cortex, suggesting migration via such structures. Large extrathymic or interlobular lymphatics communicated with a previously undescribed thymic structure - the 'lymphatic centre' - surrounded by a marginal sinus. The orientation of lymphatic valves, and the concentration of Kurloff cells within this 'lymphatic centre' at an early time after the administration of estradiol, indicate the existence of an afferent migratory pathway. The different morphology at different times after estradiol suggest that the treatment caused a dynamic remodeling of thymic lymphatic structures.
authors.affiliation: Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Sandberg
authors.forename: M
authors.initials: M
authors.lastname: Hagelin
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D006168:Guinea Pigs; D002479:Inclusion Bodies / Q000187:drug effects* / Q000648:ultrastructure; D008208:Lymphatic System / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
chemical_list: D004958:Estradiol