Mucoepidermoid tumor of the parotid gland showing a translocation (3;8)(p21;q12) and a deletion (5)(q22) as sole chromosome abnormalities.
The cytogenetic findings in a mucoepidermoid tumor of the parotid gland are described. In addition to a t(3;8)(p21;q12), all cells analyzed showed a deletion of part of the long arm of chromosome 5. Although the typical translocation of benign pleomorphic adenomas was found, histologic examination did not show remnants of a pleomorphic adenoma. Nevertheless, we assumed that the malignant tumor most likely arose in a preexisting pleomorphic adenoma. As a mechanism for malignant transformation, the loss of a suppressor gene located on the long arm of chromosome 5 is discussed.
Bullerdiek
J
J
Centre of Human Genetics and Genetic Counselling, University of Bremen, F.R.G.
Vollrath
M
M
Wittekind
C
C
Caselitz
J
J
Bartnitzke
S
S
D008949:Adenoma, Pleomorphic / Q000150:complications; D002277:Carcinoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic