[The role of the hypophysis in the immunomodulating influence of the GABA-ergic system].
In CBA mice immunized with the sheep red blood cells (5 x 10(8)), the section of the pituitary stalk prevented the changes in the immune response caused with drugs affecting the activity of GABA-ergic system. Activating effect of the benzodiazepine receptor agonist diazepam, and inhibitory effect of bicucullin on the immune response were not manifest in animals after the lesion of the hypothalamo-pituitary stalk. The mechanism of increasing of the L3T4 T-helpers in bone marrow under the effect of GABA-ergic system activity was also actualized through the hypophysis. The central GABA-ergic mechanisms of the neuroimmunomodulation are discussed.
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D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D007016:Hypophysectomy; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000502:physiology*; D010641:Phenotype; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D011963:Receptors, GABA-A; D003975:Diazepam; D001640:Bicuculline
Rol' gipofiza v immunomoduliruiushchem vliianii GAMK-ergicheskoĭ sistemy.