[The role of Na(+) pump inhibition induced by Ca2(+) ions in the development of pathologic changes during calcium overload in myocardial cells].
Ca2+ ions cause marked inhibition of (Na+ + K+)-ATPase. Strontium and barium ions exert a less pronounced inhibition of (Na+ + K+)-ATPase activity. These findings suggest the existence of a regulatory binding site for calcium ions on the (Na+ + K+)-ATPase molecule. Under physiological conditions, this binding site is presumably involved in stopping the activity of (Na+ + K+)-ATPase during depolarization of the sarcolemma. In pathological conditions which are characterized by calcium overload of cardiomyocytes inhibition of (Na+ + K+)-ATPase by calcium ions can significantly contribute to massive damage of myocardial cells. (Fig. 3, Ref. 26.).
Breier
A
A
Centra fyziologických vied SAV v Bratislave.
Durisová
V
V
Monosíková
R
R
Stankovicová
T
T
Vrbanová
A
A
Zúbor
V
V
D000818:Animals; D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000187:drug effects / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013324:Strontium / Q000494:pharmacology
D015222:Sodium Channels; D001464:Barium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium; D013324:Strontium
Uloha inhibície Na(+)-pumpy indukovanej Ca2(+)-iónmi pri rozvoji patologických zmien pocas pret'azenia myokardiálnych buniek vápnikom.