Effects of the kappa opioid receptor antagonist MR-2266-BS on the acquisition of ethanol preference.
Using a paradigm by which rats forced to drink a weak ethanol solution (2.5% w/v) (conditioning session) develop ethanol preference in consecutive retention testing days, the effects of the administration of the kappa opioid antagonist MR-2266-BS, prior to or after the forced ethanol session, were studied. Pre-conditioning subcutaneous (s.c.) administration of 1 mg/kg of MR-2266-BS induced a decrease in subsequent ethanol consumption without significantly modifying the acquisition of ethanol preference. Post-conditioning administration of MR-2266-BS (0.1, 1, 5 or 10 mg/kg) induced both a dose-dependent reduction in ethanol consumption and in preference throughout the three following days. The results of the present study provide further support of the involvement of kappa-type opioids on drinking behavior, and suggest that kappa receptors may be involved in the consumption and development of preference to ethanol.
Sandi
C
C
Cajal Institute, Department of Psychobiology, C.S.I.C., Madrid, Spain.
Borrell
J
J
Guaza
C
C
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D001575:Benzomorphans / Q000008:administration & dosage / Q000494:pharmacology*; D003213:Conditioning, Psychological; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009292:Narcotic Antagonists; D051381:Rats; D011919:Rats, Inbred Strains; D017473:Receptors, Opioid, kappa; D012044:Regression Analysis; D013395:Sucrose / Q000008:administration & dosage
D001575:Benzomorphans; D009019:Morphinans; D009292:Narcotic Antagonists; D017473:Receptors, Opioid, kappa; C027247:MR 2266; D013395:Sucrose