[The production and characteristics of transgenic mice expressing the surface protein gene of the human hepatitis B virus].
Transgenic mice were obtained that contained a gene of human hepatitis B surface antigen (HBsAg). The integrated HBsAg DNA sequences were inherited in the normal Mendelian fashion. 6 of 25 investigated transgenic mice expressed the HBsAg. The expression was detected in the serum and within the cytoplasm of hepatocytes. Specific tissue pathology was shown in these animals, including systemic hyperplasia of lymphoid tissue and degenerative changes in the liver and kidney parenchymatous cell elements.
Shvemberger
I N
IN
Ermilov
A N
AN
Kapitskaia
M Z
MZ
Dvorianchikov
G A
GA
Medvedeva
N D
ND
Ginkul
L B
LB
Tomilin
N V
NV
D000818:Animals; D004262:DNA Restriction Enzymes / Q000494:pharmacology; D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D005796:Genes / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics*; D006509:Hepatitis B / Q000235:genetics / Q000473:pathology; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008668:Metallothionein / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic / Q000235:genetics*; D010957:Plasmids / Q000187:drug effects / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics
D006514:Hepatitis B Surface Antigens; D008668:Metallothionein; D004262:DNA Restriction Enzymes
Poluchenie i kharakteristika transgennykh mysheĭ, ékspressiruiushchikh gen poverkhnostnogo belka virusa gepatita B cheloveka.