title: Prevalence and serotype specificity of rotavirus antibodies in different age groups of Ecuadorian infants.
abstract: The age-specific prevalence of antibody to rotavirus was studied in 1404 Ecuadorian children enrolled in a national nutrition and health survey. ELISA and neutralizing antibody analysis showed evidence for primary rotavirus infection in 6- to 12-month-old children, who showed also a more-than-threefold increase in significant diarrheal episodes in comparison with infants less than 6 months old. At this age, 56% of the sera with neutralizing antibody were monospecific. With increasing age a gradual decrease in prevalence of monospecific sera, to 10% in 5-year-old children, was observed. Monospecific sera were directed in decreasing frequency against serotypes 4 (56%), 3 (20%), 2 (14%), and 1 (10%). Serotype 4-specific antibody was acquired at an earlier age than were antibodies to the other serotypes, and 91% of sera with dual specificity neutralized serotype 4, whereas only 2% of sera that neutralized three serotypes failed to neutralize serotype 4.
authors.affiliation: Nestlé Research Center, Nestec Ltd., Lausanne, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Brüssow
authors.forename: J
authors.initials: J
authors.lastname: Sidoti
authors.forename: D
authors.initials: D
authors.lastname: Barclay
authors.forename: J
authors.initials: J
authors.lastname: Sotek
authors.forename: H
authors.initials: H
authors.lastname: Dirren
authors.forename: W B
authors.initials: WB
authors.lastname: Freire
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D000918:Antibody Specificity; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000382:microbiology; D004484:Ecuador / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D009500:Neutralization Tests; D015995:Prevalence; D012401:Rotavirus / Q000145:classification* / Q000276:immunology; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000382:microbiology; D012703:Serotyping
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M