[The effect of cadmium on neuromuscular transmission in rabbit blood vessels].
Influence of cadmium on contractions of isolated v.portae of a rabbit, elicited by transmural nerve stimulation and by exogene norepinephrine, has been studied. Low concentrations of cadmium (10(-6) mol/l) potentiated contractions of the vessels in response to transmural nerve stimulation but they did not influence the magnitude of response to norepinephrine. Higher concentrations of cadmium (10(-5) - 10(-4) mol/l) inhibited contractions of v.portae elicited by both adrenergic stimuli. The results indicate that the effect of cadmium on contractions induced by transmural nerve stimulation is realized predominantly pre-synaptically, probably by influence on homeostasis of calcium in the nerve ending. Potentiation of responses of v.portae indicates a mechanism by which ions of cadmium could contribute to the development of hypertension.
Holécyová
A
A
Ustavu normálnej a patologickej fyziológie SAV v Bratislave.
Török
J
J
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011169:Portal Vein / Q000294:innervation* / Q000502:physiology; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D002104:Cadmium
Vplyv kadmia na nervovosvalový prenos v cievach králika.