Alpha 2-adrenoceptor inhibition in patients with vibration white fingers.
In healthy subjects the physiological vasoconstriction to local cooling has been linked to sympathetic adrenoceptors of the alpha2-subtype. The present study was designed to determine if the vasoconstriction in response to local cooling in patients suffering from vibration white fingers can be diminished by alpha2-adrenoceptor inhibition. Six men with vibration white fingers, verified in a cold provocation test, were examined. To study the effect of local skin cooling blood flow was measured with laser doppler technique on the dorsum of dig. II or III. The temperature of the laser doppler probe was regulated by Peltier elements. Temperature could be lowered from 30 degrees C to 20 degrees C within 30s. Measurements were performed before and after local inhibition of the alpha2-adrenoceptors. This was achieved by the introduction of the selective alpha2-adrenoceptor inhibitor, rauwolscine, into the finger skin by iontophoresis. During control conditions local cooling consistently resulted in a marked vasoconstriction. Inhibition of the alpha2-adrenoceptors by rauwolscine completely abolished this effect. The present data indicate that substances inhibiting alpha2-adrenoceptors may be of therapeutic value in patients with vibration white fingers.
Lindblad
L E
LE
Department of Clinical Physiology, Södersjukhuset, Stockholm, Sweden.
Ekenvall
L
L
D001381:Azepines / Q000494:pharmacology; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D008297:Male; D011928:Raynaud Disease / Q000503:physiopathology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D014732:Vibration / Q000009:adverse effects*; D015016:Yohimbine / Q000494:pharmacology
D001381:Azepines; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; C015603:azepexole