The use of sensory action potentials in the diagnosis of peripheral nerve disease.
We review the different measurements that can be derived from recordings of compound sensory action potentials, and describe how less commonly measured aspects may be of use in clinical situations. In addition to the frequently obtained maximum conduction velocity and amplitude, minimum conduction velocity may be measured if near nerve electrodes and response averaging are used. Minimum conduction velocity is a sensitive measure of both axonal and demyelinating peripheral nerve pathology. Activity-dependent conduction is another aspect of sensory conduction that may provide additional information for the clinician. Refractory period of transmission has been used to diagnose subtle demyelinating lesions, as well as some axonal disorders. Supernormal period and the conduction of trains of stimuli may also be useful, although, at present, they remain predominantly research tools.
Shefner
J M
JM
Division of Neurology, Brigham and Women's Hospital, Boston, MA 02115.
Dawson
D M
DM
D000200:Action Potentials; D006801:Humans; D009431:Neural Conduction / Q000502:physiology*; D009482:Neurophysiology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology