Corticosteroids in asthma.
The use of corticosteroids in the treatment of asthma has significantly decreased the morbidity and mortality from this disease. However, corticosteroids have devastating side effects when given frequently or for prolonged periods. High doses of systemic corticosteroid preparations should be used only during bouts of acute bronchospasm, whereas the lowest possible dose needed to control symptoms is recommended for the treatment of chronic asthma. Aerosolized steroids offer an alternative to systemic preparations and have less associated morbidity. Various corticosteroid preparations have various potencies and durations of action that need to be considered. Patients with coexisting liver disease require preparations that do not need hepatic hydroxylation, whereas patients with congestive heart failure require preparations that minimize salt retention. When asthma and pregnancy coexist, it is vital that symptoms of bronchospasm are controlled to protect the fetus. During stressful situations, such as surgery, it is important to consider the possibility of hypothalamic-pituitary-adrenal axis suppression if the asthmatic patient has been previously treated with corticosteroids.
Dunlap
N E
NE
Department of Medicine, University of Alabama Birmingham.
Bailey
W C
WC
D000208:Acute Disease; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D002180:Candidiasis, Oral / Q000139:chemically induced; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011987:Receptors, Steroid / Q000378:metabolism
D000336:Aerosols; D005938:Glucocorticoids; D011987:Receptors, Steroid; D011241:Prednisone; D006854:Hydrocortisone