GABAA type binding sites on membranes of spermatozoa.
The binding of [3H] gamma-aminobutyric acid (GABA) to seminal membranes of swines and rams was examined. Specific, GABA binding was demonstrated in both species, which showed the features of GABAA type receptors. The affinity of binding was similar in both species, whereas the density of seminal GABA binding sites was 5 times higher in swine. Our findings suggest that GABA may have a direct effect on spermatozoa.
Erdö
S L
SL
Department of Anatomy, Georg-August University, Göttingen, FRG.
Wekerle
L
L
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D008297:Male; D011963:Receptors, GABA-A / Q000378:metabolism; D012756:Sheep; D013094:Spermatozoa / Q000378:metabolism*; D013552:Swine; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid