title: [Primary and metastatic liver tumors--evaluation of tumor regression and response with regional cytostatic drug therapy by sonography and fine needle puncture histology].
abstract: Primary and metastatic hepatic tumours--evaluation of tumour regression or response under regional cytostasis with sonography and fine needle puncture histology. The results obtained through the use of regional liver perfusion with a 5-FU-BCNU application on non-resectable hepatic metastases of colorectal tumours following primary curative removal of the primary tumour and primary hepatocellular carcinomas display comparable results to those specified in the literature after the use of 5-FUDR. The effectivity of the cytostasis regime is checked using histological criteria. The ultrasonically guided fine needle puncture can prove the success of the cytostasis regime on the basis of cytomorphologic criteria more reliably than has been the case up to now. Patients displaying histological signs of tumour regression have a significantly longer survival time than those displaying no signs of regression (12 +/- 9.2 vs 4.5 +/- 2.2 months; p less than 0.05).
authors.affiliation: Medizinische Klinik I, Städtische Krankenanstalten Köln, Krankenhaus Merheim.
authors.forename: B
authors.initials: B
authors.lastname: Krakamp
authors.forename: R
authors.initials: R
authors.lastname: Schmitz
authors.forename: G
authors.initials: G
authors.lastname: Knöpfle
authors.forename: P
authors.initials: P
authors.lastname: Leidig
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D002330:Carmustine / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D014463:Ultrasonography
chemical_list: D005472:Fluorouracil; D002330:Carmustine
vernacular_title: Primäre und metastatische Lebertumore--Beurteilung der Tumorregression bzw.-response unter regionaler Zytostase durch Sonographie und Feinnadelpunktionshistologie.