[Problems with long-term immunosuppression following organ transplantation].
Long-term immunosuppression is followed by an increase of malignancies (skin cancer, lymphomas and Kaposi's sarkoma). Among the infectious complications an incidence of bacteraemia up to 48% is found, a relative increase of infection with listeria and salmonella, and viruses from the herpes group. The major side effect of azathioprine is haematologic, whereas Cyclosporin A is nephrotoxic. Three classes of renal functional impairment by Cyclosporine are defined: 1. renal dysfunction, 2. acute nephrotoxicity and 3. chronic nephrotoxicity. Appropriate ways to handle chronic nephrotoxicity are discussed.
Thiel
G
G
Departemente für Chirurgie, Medizin und Pathologie, Kantonsspital, Universität Basel.
Landmann
J
J
Mihatsch
M
M
D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D009369:Neoplasms / Q000276:immunology*; D009894:Opportunistic Infections / Q000276:immunology*; D011379:Prognosis; D012307:Risk Factors; D014181:Transplantation Immunology / Q000276:immunology*
D007166:Immunosuppressive Agents
Probleme der Langzeit-Immunsuppression nach Organtransplantation.