[Calcitonin gene products and the skeleton].
Calcitonin is the most important hypocalcaemic peptide. Its action is brought about through inhibition of bone resorption. CGRP exerts the same effect on the skeleton albeit in much higher concentrations probably through interaction with calcitonin receptors on osteoclasts. PAS-57 stimulates the incorporation of thymidine into osteoblasts. A possible stimulation of bone formation needs to be verified in vivo.
Fischer
J A
JA
Forschungslabor für Calciumstoffwechsel, Orthopädischen Universitätsklinik Balgrist.
Born
W
W
D001862:Bone Resorption / Q000517:prevention & control; D002116:Calcitonin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D010446:Peptide Fragments; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface; C037553:katacalcin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D013936:Thymidine
Calcitonin Gen Produkte und das Skelett.