title: [Portal perfusion defect after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma (HCC)].
abstract: Serial changes of intrahepatic portal blood flow were studied before and after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma (HCC). In all eight patients examined, wedge-shaped perfusion defects distal to the tumor were clearly demonstrated by dynamic sequential computed tomography during arterial portography (CT-AP). However, no abnormalities of arterial blood flow were detected in the areas of reduced portal blood flow by enhanced computed tomography (CT), indicating that portal blood flow of the liver was selectively decreased by PEIT. Moreover, histopathological finding of two resected liver tissues after PEIT revealed organized thrombi in the portal veins in the non-cancerous liver tissues distal to the tumors. These findings suggest that decreased segmental portal flow is frequent after PEIT and obstructive vasculitis is caused by the drainage of ethanol injected in the tumor.
authors.affiliation: First Department of Internal Medicine, Kanazawa University.
authors.forename: E
authors.initials: E
authors.lastname: Matsushita
authors.forename: M
authors.initials: M
authors.lastname: Unoura
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: K
authors.initials: K
authors.lastname: Notsumata
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Arai
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000188:drug therapy*; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000187:drug effects / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D000431:Ethanol