Effect of salicylates on antibiotic sensitivity.
The effect of sodium salicylate (SA) or acetylsalicylate (ASA) on sensitivity to two different antibiotics on porin-deficient Gram-negative bacteria was investigated. Neither SA nor ASA nor any combinations of the two drugs within the therapeutic range altered minimum inhibitory concentrations (MICs) or minimum bactericidal concentrations (MBCs) of mezlocillin and ciprofloxacin against Pseudomonas aeruginosa, Serratia marcescens and Proteus vulgaris strains. It is concluded that SA and ASA do not seem to interfere with antimicrobial therapy of Gram-negative porin deficient bacteria.
Esposito
S
S
Clinic of Infectious Diseases, University of Naples, Italy.
Noviello
S
S
Maggiolo
F
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000502:physiology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007769:Lactams; D011514:Proteus vulgaris / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology; D011897:Random Allocation; D012459:Salicylates / Q000494:pharmacology*; D012706:Serratia marcescens / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D007769:Lactams; D015363:Quinolones; D012459:Salicylates; D001241:Aspirin