Blood biochemical response to sodium bicarbonate infusion during sublethal endotoxemia in ponies.
Hypertonic NaHCO3 infusion caused blood volume expansion, increased blood bicarbonate concentration, and delayed the onset of hypophosphatemia in ponies with endotoxemia. However, NaHCO3 infusion did not normalize blood pH, and it increased blood L-lactate concentration, and caused hypokalemia, hypernatremia, and hyperosmolality. The deleterious effects of NaHCO3 infusion in endotoxemia ponies outweighed the beneficial effects. The role of hypertonic NaHCO3 given IV for treatment of endotoxemia in equids must be reevaluated.
Gossett
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KA
Department of Veterinary Pathology, Louisiana State University, Baton Rouge 70803.
French
D D
DD
Cleghorn
B
B
Church
G E
GE
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000097:blood* / Q000139:chemically induced; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous / Q000662:veterinary; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D012772:Shock, Septic / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D012964:Sodium / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D004731:Endotoxins; D007773:Lactates; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D012964:Sodium