[The physiological mechanisms of the antihypoxic action of the liposomes].
The effect of phospholipids introduced into the vascular bed in the form of liposomes, was studied in pats in conditions of breathing with hypoxic gas mixture containing 7% of oxygen in nitrogen. The liposomes were shown to improve the oxygen diffusion from the blood into tissues and from air to the blood. In the result of this, the degree of the tissue hypoxia is considerably reduced, the process of peroxide oxidation of lipids is inhibited, and the efficacy of external respiration and gas exchange is increased.
Pozharov
V P
VP
Miniaĭlenko
T D
TD
Stefanov
A V
AV
Bryginskiĭ
S A
SA
Seredenko
M M
MM
Lishko
V K
VK
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008081:Liposomes; D009584:Nitrogen / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D010313:Partial Pressure; D010743:Phospholipids / Q000008:administration & dosage* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D002245:Carbon Dioxide; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
Nekotorye fiziologicheskie mekhanizmy antigipoksicheskogo deĭstviia liposom.