title: Preliminary Doppler studies on the uterine artery and myometrium in trophoblastic tumours requiring chemotherapy.
abstract: The uterine circulation in 38 patients with invasive mole or choriocarcinoma were investigated using Doppler ultrasound. Twenty-six non-pregnant and 23 pregnant volunteers were assessed in a similar fashion to act as control groups. The pulsatility indices were significantly lower in the patients with trophoblastic disease when compared with the non-pregnant and pregnant groups (Student's t-test; P less than 0.001 and P less than 0.02 respectively). The uterine circulation in persistent trophoblastic diseases shows a characteristic Doppler profile suggesting the presence of large low resistance blood vessels. This may be useful in the initial assessment of these tumours before cytotoxic chemotherapy.
authors.affiliation: Charing Cross Hospital, London.
authors.forename: M G
authors.initials: MG
authors.lastname: Long
authors.forename: J E
authors.initials: JE
authors.lastname: Boultbee
authors.forename: R H
authors.initials: RH
authors.lastname: Begent
authors.forename: M E
authors.initials: ME
authors.lastname: Hanson
authors.forename: K D
authors.initials: KD
authors.lastname: Bagshawe
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002822:Choriocarcinoma / Q000098:blood supply* / Q000188:drug therapy; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000098:blood supply* / Q000188:drug therapy; D009215:Myometrium / Q000098:blood supply*; D011247:Pregnancy; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000188:drug therapy