title: Phase II trial of 4' deoxydoxorubicin (DXDX) for unresectable non-small cell bronchogenic carcinoma. An Illinois Cancer Council study.
abstract: A phase II trial of 4' Deoxydoxorubicin (DXDX) was conducted in unresectable previously untreated non-small cell lung cancer patients. DXDX was administered every 3 weeks by short intravenous infusion at a starting dose of 30 mg/m2, with dose escalation to 40 mg/m2 toxicity permitting. Four responses, all partial, were observed in 35 evaluable patients, for a response rate of 11% (95% confidence limits 3.2% and 26.7%). Myelosuppression was the dose-limiting toxicity. Cardiotoxicity was not seen. DXDX has minimal activity against non-small cell lung cancer as a single agent at the dosage used in this study.
authors.affiliation: Department of Medicine, University of Illinois at Chicago.
authors.forename: C
authors.initials: C
authors.lastname: Rose
authors.forename: T E
authors.initials: TE
authors.lastname: Lad
authors.forename: L J
authors.initials: LJ
authors.lastname: Kilton
authors.forename: J
authors.initials: J
authors.lastname: Schor
authors.forename: S T
authors.initials: ST
authors.lastname: Rosen
authors.forename: A H
authors.initials: AH
authors.lastname: Rossof
authors.forename: R R
authors.initials: RR
authors.lastname: Blough
authors.forename: C M
authors.initials: CM
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008875:Middle Aged; D015337:Multicenter Studies as Topic
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; C030851:esorubicin