In vitro prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes.
Glioblastoma cells constitutively produce various amounts of PGE2 (prostaglandin E2) in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 10(7) of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells.
Sawamura
Y
Y
Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Diserens
A C
AC
de Tribolet
N
N
D001932:Brain Neoplasms / Q000378:metabolism*; D003470:Culture Media; D015232:Dinoprostone / Q000096:biosynthesis* / Q000502:physiology; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors*; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D011863:Radioimmunoassay; D014407:Tumor Cells, Cultured
D003470:Culture Media; D007376:Interleukin-2; D015232:Dinoprostone