G0 is a major growth cone protein subject to regulation by GAP-43.
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.
Strittmatter
S M
SM
Developmental Biology Laboratory, Massachusetts General Hospital, Boston.
Valenzuela
D
D
Kennedy
T E
TE
Neer
E J
EJ
Fishman
M C
MC
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002462:Cell Membrane / Q000032:analysis; D019922:GAP-43 Protein; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006133:Growth Substances / Q000502:physiology*; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000502:physiology*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010446:Peptide Fragments / Q000302:isolation & purification / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D011956:Receptors, Cell Surface; D017981:Receptors, Neurotransmitter; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction; D013873:Thionucleotides / Q000378:metabolism
D019922:GAP-43 Protein; D006133:Growth Substances; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D017981:Receptors, Neurotransmitter; D013873:Thionucleotides; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins