An experimental assessment of cyanide challenge dose-response, time-course and recovery of indicative toxicity parameters.
1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c. was selected. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. It was found that cyanide effects continued for at least 3 days; after the parameters had recovered normal values.
Buzaleh
A M
AM
Centro de Investigaciones sobre Porfirinas y Porfirias CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina.
Vazquez
E S
ES
Batlle
A M
AM
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009206:Myocardium / Q000201:enzymology; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D013884:Thiosulfate Sulfurtransferase / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D003576:Electron Transport Complex IV; D013884:Thiosulfate Sulfurtransferase; D011190:Potassium Cyanide