An update of cancer mortality among chrysotile asbestos miners in Balangero, northern Italy.
The mortality experience of a cohort of chrysotile miners employed since 1946 in Balangero, northern Italy was updated to the end of 1987 giving a total of 427 deaths out of 27,010 man-years at risk. A substantial excess mortality for all causes (standardised mortality ratio (SMR) = 149) was found, mainly because of high rates for some alcohol related deaths (hepatic cirrhosis, accidents). For mortality from cancer, however, the number of observed deaths (82) was close to that expected (76.2). The SMR was raised for oral cancer (SMR 231 based on six deaths), cancer of the larynx (SMR 267 based on eight deaths), and pleura (SMR 667 based on two deaths), although the excess only reached statistical significance for cancer of the larynx. Rates were not increased for lung, stomach, or any other type of cancer. No consistent association was seen with duration or cumulative dust exposure (fibre-years) for oral cancer, but the greatest risks for laryngeal and pleural cancer were in the highest category of duration and degree of exposure to fibres. Although part of the excess mortality from laryngeal cancer is probably attributable to high alcohol consumption in this group of workers, the data suggest that exposure to chrysotile asbestos (or to the fibre balangeroite that accounts for 0.2-0.5% of total mass in the mine) is associated with some, however moderate, excess risk of laryngeal cancer and pleural mesothelioma. The absence of excess mortality from lung cancer in this cohort is difficult to interpret.
Piolatto
G
G
Istituto di Medicina del Lavoro, Università di Torino, Italy.
Negri
E
E
La Vecchia
C
C
Pira
E
E
Decarli
A
A
Peto
J
J
D000428:Alcohol Drinking / Q000009:adverse effects; D001194:Asbestos / Q000009:adverse effects*; D017632:Asbestos, Serpentine; D002423:Cause of Death; D015331:Cohort Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000401:mortality; D008297:Male; D008906:Mining; D009062:Mouth Neoplasms / Q000401:mortality; D009369:Neoplasms / Q000401:mortality*; D009784:Occupational Diseases / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D010997:Pleural Neoplasms / Q000401:mortality; D013997:Time Factors
D017632:Asbestos, Serpentine; D001194:Asbestos