title: [An experimental study of human recombinant gamma interferon with a proteolytically reduced C-end area of the protein].
abstract: The work presents the results of experimental study of gamma interferon obtained by gene engineering techniques on the basis of Escherichia coli producer strains. The study has revealed that gamma interferon, whose molecular weight is 15 KD, due to intracellular proteolytic degradation shows the absence of some amino acids at the C-end of protein and is electrophoretically homogeneous, while its antiviral, antiproliferative and immunomodulating effects are less pronounced than those of gamma interferon with a molecular weight of 18 KD.
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
authors.forename: V A
authors.initials: VA
authors.lastname: Bumialis
authors.forename: S A
authors.initials: SA
authors.lastname: Tsarev
authors.forename: S G
authors.initials: SG
authors.lastname: Arsenian
authors.forename: V A
authors.initials: VA
authors.lastname: Parfenov
authors.forename: D V
authors.initials: DV
authors.lastname: Paulauskas
authors.forename: A V
authors.initials: AV
authors.lastname: Klenova
authors.forename: L A
authors.initials: LA
authors.lastname: Denisov
authors.forename: M M
authors.initials: MM
authors.lastname: Mauritsas
authors.forename: V D
authors.initials: VD
authors.lastname: Kol'tsov
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004686:Encephalomyocarditis virus / Q000187:drug effects; D004926:Escherichia coli; D006801:Humans; D007371:Interferon-gamma / Q000187:drug effects* / Q000494:pharmacology; D051379:Mice; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000494:pharmacology*; D011994:Recombinant Proteins; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma; D010447:Peptide Hydrolases
vernacular_title: Eksperimental'noe izuchenie rekombinantnogo chelovecheskogo gamma-interferona s proteoliticheski redutsirovannym C-kontsevym uchastkom belka.