Heritable ventricular septal defect in Yucatan miniature swine.
A heritable ventricular septal defect (VSD) was found in a strain of Yucatan miniature swine. The defect was determined to be a high membranous VSD analogous in anatomic location to the most common from of VSD in humans. Eighteen animals were studied clinically, hemodynamically and at necropsy to characterize the defect. Three mature animals developed pulmonary hypertension. Three animals were found to have a patent foramen ovale (PFO) in addition to the VSD. VSD is heritable probably due to polygenic factors. VSD in Yucatan miniature swine may be a suitable model of the human disease syndrome.
Swindle
M M
MM
Department of Comparative Medicine, Medical University of South Carolina, Charleston 29425.
Thompson
R P
RP
Carabello
B A
BA
Smith
A C
AC
Hepburn
B J
BJ
Bodison
D R
DR
Corin
W
W
Fazel
A
A
Biederman
W W
WW
Spinale
F G
FG
D000818:Animals; D005260:Female; D006337:Heart Murmurs; D006345:Heart Septal Defects, Ventricular / Q000235:genetics* / Q000503:physiopathology; D006439:Hemodynamics; D008297:Male; D010375:Pedigree; D012189:Retrospective Studies; D013552:Swine; D013553:Swine Diseases / Q000235:genetics* / Q000503:physiopathology; D013556:Swine, Miniature / Q000235:genetics*