[The biochemical and morphological changes in the body in experimental thymomegaly and their correction with sodium selenite].
A model of thymomegaly in puppies was used for a study of changes in the content of nucleic acids, protein, glycogen, ATP, cuprum, manganese, iron, zinc, succinate dehydrogenase and cytochromoxidase activity in tissues of the thymus, spleen, adrenal glands, liver and associated morphological changes in tissues of these organs, lymph nodes and the thyroid. In animals receiving sodium selenite normalization of the above indices was more marked than in untreated animals.
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D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006984:Hypertrophy / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008206:Lymphatic Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008939:Mitotane / Q000633:toxicity; D012643:Selenium / Q000627:therapeutic use*; D018038:Sodium Selenite; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*
D008939:Mitotane; D012643:Selenium; D018038:Sodium Selenite
Nekotorye biokhimicheskie i morfologicheskie izmeneniia v organizme pri éksperimental'noĭ timomegalii i ikh korrektsiia selenitom natriia.