Epidermal growth factor increases cyclic AMP levels in pregnant rat mammary gland explants.
Addition of epidermal growth factor (EGF) to a rat mammary organ culture results in increase levels of intracellular cyclic AMP. This dose dependent EGF effect occurs at physiological concentrations of the hormone and was maximal in early and middle pregnancy.
Lavandero
S
S
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
Ocaranza
M P
MP
Sapag-Hagar
M
M
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D007774:Lactation / Q000502:physiology; D008321:Mammary Glands, Animal / Q000378:metabolism*; D009924:Organ Culture Techniques; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D004815:Epidermal Growth Factor; D000242:Cyclic AMP