title: Long-term suppression of severe recurrent genital herpes simplex infections with oral acyclovir: a dose-titration study.
abstract: Twenty immunocompetent patients, four females and 16 males, with severe recurrent genital herpes (median number of recurrences the previous year 16, range (8-24] entered an open continuous long-term suppressive treatment with oral acyclovir (ACV) for 12 months. The study included a dose-titration schedule: (ACV, 200 mg x 4/1-3 months, ACV, 400 mg x 2/4-6 months, ACV, 200 mg x 2/7-9 months, and ACV, 400 mg x 1/10-12 months). Patients with recurrences on steps two and three received an alternative dose of ACV, 200 mg x 3. Otherwise patients entered the previous dose-step. Five (20%) of patients were completely free of symptoms (recurrences and abortive lesions) during the four dose-reduction periods. A further nine patients (50%) could be dose-reduced to 200 mg x 3 without symptoms. Isolates from three patients showed a decrease in virus sensitivity after ceasing treatment. In conclusion, 14/20 of treated patients could be dose reduced to 200 mg x 2-3 without selection of HSV strains showing clinically important decreases in sensitivity towards ACV.
authors.affiliation: Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Kroon
authors.forename: C S
authors.initials: CS
authors.lastname: Petersen
authors.forename: L P
authors.initials: LP
authors.lastname: Andersen
authors.forename: J R
authors.initials: JR
authors.lastname: Rasmussen
authors.forename: B F
authors.initials: BF
authors.lastname: Vestergaard
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage* / Q000627:therapeutic use; D000284:Administration, Oral; D004352:Drug Resistance, Microbial / Q000502:physiology; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects; D013997:Time Factors
chemical_list: D000212:Acyclovir