[Change of preoptic opiate receptors after injection of 6-OHDA into sublocus coeruleus in the rabbit].
The formaldehyde histofluorescence method and receptor autoradiography were respectively used to investigate the distribution and densities of the catecholamine (CA) terminals and [3H]-etorphine binding sites, after 20 days of injection of 6-hydroxydopamine (6-OHDA) into N. subcoerulens of the rabbit. The results showed that both CA terminals and [3H]-etophine binding sites in the preoptic area, especially in the medial preoptic area, were reduced in 6-OHDA pretreated animals, thus suggesting the possible location of opioid receptors on the CA terminals.
Zhu
J M
JM
Department of Neurobiology, Shanghai Medical University.
He
X P
XP
Li
K Y
KY
Huang
D K
DK
Cao
X D
XD
D000818:Animals; D001345:Autoradiography; D002395:Catecholamines / Q000378:metabolism; D005048:Etorphine / Q000378:metabolism; D005260:Female; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D016627:Oxidopamine; D011301:Preoptic Area / Q000378:metabolism*; D011817:Rabbits; D011957:Receptors, Opioid / Q000187:drug effects*
D002395:Catecholamines; D006892:Hydroxydopamines; D011957:Receptors, Opioid; D005048:Etorphine; D016627:Oxidopamine