Chimeras of the Gs alpha subunit that had the NH2- or COOH-terminal sequence substituted for the corresponding region of the Gi alpha subunit constitutively activate adenylyl cyclase.
Heasley
L E
LE
Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
Dhanasekaran
N
N
Gupta
S K
SK
Osawa
S
S
Johnson
G L
GL
D000262:Adenylyl Cyclases / Q000502:physiology*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002478:Cells, Cultured; D002678:Chimera / Q000235:genetics* / Q000502:physiology; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology; D005260:Female; D019204:GTP-Binding Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000031:analogs & derivatives*; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives* / Q000032:analysis / Q000235:genetics / Q000502:physiology; D010053:Ovary / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D010641:Phenotype; D010957:Plasmids; D011494:Protein Kinases / Q000378:metabolism; D013539:Simian virus 40 / Q000235:genetics; D013873:Thionucleotides / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D014162:Transfection
D000596:Amino Acids; D013873:Thionucleotides; C034882:guanosine 5'-O-(1-thiotriphosphate); D016244:Guanosine 5'-O-(3-Thiotriphosphate); D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D011494:Protein Kinases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases