Antibody to hepatitis C virus after a vapour-heated factor VIII concentrate. The Study Group of the Fondazione dell'Emofilia.
To evaluate whether or not clotting factor concentrates exposed to virucidal procedures transmitted hepatitis C, sera obtained in 1984-1986 from 27 previously untreated hemophiliacs infused with a vapour-heated factor VIII concentrate were tested retrospectively for the antibody to the hepatitis C virus (anti-HCV). A 2-year-old hemophiliac, negative for anti-HCV before administration of concentrate, seroconverted at week 12 and remained anti-HCV positive thereafter. Both his parents were anti-HCV negative and he had no other household contact. The patient had also become HBsAg positive at week 8 and had at the same time a marked elevation of alanine aminotransferase. His double infection with the hepatitis B and C viruses indicates that hot vapour was not completely effective in inactivating these viruses.
Mannucci
P M
PM
A. Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy.
Zanetti
A R
AR
Colombo
M
M
Chistolini
A
A
De Biasi
R
R
Musso
R
R
Tamponi
G
G
D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D004340:Drug Contamination; D005169:Factor VIII / Q000009:adverse effects* / Q000302:isolation & purification; D006467:Hemophilia A / Q000188:drug therapy / Q000276:immunology; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000635:transmission; D006358:Hot Temperature; D006801:Humans; D008297:Male; D065227:Transfusion Reaction; D014835:Volatilization
D000914:Antibodies, Viral; D005169:Factor VIII