[Changes in the intracellular concentration of cyclic nucleotides in the differentiation of neuroblastoma cells].
High performance liquid chromatography allows a simultaneous determination of ATP, CTP, GTP, and the cyclic nucleotides. During cell differentiation initiated by DBcAMP, we observed an increase in ATP, cAMP, GTP and an decrease in CTP, cCMP, and cGMP levels. It is being discussed the changes of relation between the triphosphates their corresponding cyclic nucleotides during the differentiation of NB cells.
Busse
E
E
J. W. Goethe-Universität, Kinderklinik, Frankfurt.
Kornhuber
B
B
D002454:Cell Differentiation / Q000502:physiology*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D009447:Neuroblastoma / Q000473:pathology*; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000473:pathology*
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP
Veränderungen der intrazellulären Konzentrationen der zyklischen Nukleotide während der Differenzierung von Neuroblastomzellen.