Changes in number of alpha-adrenergic receptor subtypes in hepatocytes from rats fed 3'-methyl-4-dimethylaminoazobenzene.
Changes in numbers of alpha 1- and alpha 2-adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB), were examined. alpha 1-Adrenergic receptors, measured in terms of [3H]prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. alpha 2-Adrenergic receptors, measured in terms of [3H]clonidine binding, transiently increased 3-fold over the control at 2 weeks. These changes in the early period of the 3'-MeDAB diet intake may be related to hepatocarcinogenesis.
Miyamoto
K
K
Third Division of the Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University, Kanazawa.
Sanae
F
F
Kohei
K
K
Nomura
M
M
Koshiura
R
R
D000818:Animals; D003000:Clonidine / Q000378:metabolism; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008749:Methyldimethylaminoazobenzene / Q000494:pharmacology*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D004124:p-Dimethylaminoazobenzene
D011942:Receptors, Adrenergic, alpha; D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene; D003000:Clonidine; D011224:Prazosin