Acid and alkaline phosphatase activities in lithium treated testis, prostate and seminal vesicles of adult albino rats: evidence of duration and dose dependent response.
Changes in the activities of acid and alkaline phosphatase were observed in the testis, prostate and seminal vesicle after the injection of lithium chloride at the doses of 100, 200 and 400 micrograms/100 g body weight/day for 7, 14 and 21 days. The studies indicate that 200 and 400 micrograms/100 g body weight for 14 days and 21 days showed a significant inhibition in the activity of acid phosphatase in all the above reproductive organs. There is a significant stimulation of alkaline phosphatase activity at the doses of 200 and 400 micrograms of lithium after 21 days of treatment in testis, prostate and seminal vesicle along with significant decrease in accessory sex organs weight in comparison to control animal. Therefore, it is evident that the effect of lithium on male reproductive organs mainly depends on the amount of the drug being injected and the duration of treatment to it.
Ghosh
D
D
Department of Physiology, University College of Science and Technology, Calcutta University, India.
Biswas
N M
NM
Chaudhuri
A
A
Ghosh
A K
AK
Ghosh
P K
PK
D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005837:Genitalia, Male / Q000201:enzymology*; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects / Q000201:enzymology; D013737:Testis / Q000187:drug effects / Q000201:enzymology
D002712:Chlorides; D008094:Lithium; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D018021:Lithium Chloride