Antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid.
The antiinflammatory activity of 4-acetylaminophenylacetic acid (MS-932) was investigated. MS-932 did not suppress the acute inflammation of carrageenin-induced paw edema in rats or of primary swelling in adjuvant arthritic rats. However, prophylactic treatment with MS-932 inhibited secondary inflammation in adjuvant arthritic rats. MS-932 also restored to normal the weight of the spleen and the serum albumin/globulin ratio of adjuvant arthritic rats. In addition to its prophylactic effect, MS-932 had a therapeutic effect on adjuvant arthritis. In in vitro tests, MS-932 did not inhibit prostaglandin E2 biosynthesis from arachidonic acid by sheep seminal vesicle microsomal enzyme or superoxide generation by guinea pig neutrophils stimulated with opsonized zymosan. MS-932 had no analgesic effect in mice and no antipyretic effect in rats. These results indicate that MS-932 suppresses adjuvant arthritis through modulation of the immune system.
Fujisawa
H
H
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Nishimura
T
T
Inoue
Y
Y
Ogaya
S
S
Shibata
Y
Y
Nakagawa
Y
Y
Sato
S
S
Kimura
K
K
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone / Q000096:biosynthesis; D004487:Edema / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010648:Phenylacetates; D013481:Superoxides; C052562:4-(acetylamino)benzeneacetic acid; D015232:Dinoprostone