title: Mortality from liver disease among Italian vinyl chloride monomer/polyvinyl chloride manufacturers.
abstract: The possible association in humans between nonangiosarcoma primary liver tumors (PLC-non-A), particularly hepatocellular carcinoma (HCC), and exposure to vinyl chloride monomer (VCM) is supported by both experimental and human data. This article presents a review of the information regarding 253 deaths that occurred in seven plants manufacturing VCM/PVC and one plant extruding PVC. The retrieval of clinical and pathological data, in addition to the information from death certificate, is referred to as "best evidence" (BE). BE has been carried out for 63 deaths. A total of 14 primary liver cancer (PLC) were detected: seven were angiosarcoma (PLC-A), and two of the remaining seven were hepatocellular carcinoma (HCC). In our series of 14 PLC cases, there was no significant difference between PLC-A and PLC-non-A as to length of exposure and latency. There was no noticeable difference in terms of job title between ASL and non-ASL cases. The list of longest held jobs shows the presence of various job titles, different from autoclave cleaner, for primary liver cancer, PLC-A and PLC-non-A. In conclusion, our observations show that VCM may have a broader carcinogenicity action on the liver and that exposure lower than that occurring in autoclave cleaning can cause primary liver cancer, both angiosarcoma and nonangiosarcoma.
authors.affiliation: Department of Animal and Human Biology, University of Rome, La Sapienza, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pirastu
authors.forename: P
authors.initials: P
authors.lastname: Comba
authors.forename: A
authors.initials: A
authors.lastname: Reggiani
authors.forename: V
authors.initials: V
authors.lastname: Foa
authors.forename: A
authors.initials: A
authors.lastname: Masina
authors.forename: C
authors.initials: C
authors.lastname: Maltoni
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality*; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality*; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality*; D011143:Polyvinyl Chloride / Q000633:toxicity*; D011145:Polyvinyls / Q000633:toxicity*; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
chemical_list: D011145:Polyvinyls; D014753:Vinyl Compounds; D011143:Polyvinyl Chloride; D014752:Vinyl Chloride