Alterations of neuroreceptors in nasal hyperreactivity.
Cholinergic and adrenergic abnormalities have been observed in nasal allergy and may be due to changes in pharmacological characteristics of neuroreceptors. Radioligand receptor binding studies demonstrated no significant changes in affinities or densities of alpha-adrenoceptors, a decreased number of beta-adrenoceptors and a decreased affinity combined with a decreased number of muscarinic acetylcholine receptors.
van Megen
Y J
YJ
Department of Otorhinolaryngology, St Radboud Hospital, Nijmegen, The Netherlands.
Rodrigues de Miranda
J F
JF
Klaassen
A B
AB
D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D011941:Receptors, Adrenergic / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012130:Respiratory Hypersensitivity / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter