[Cytomegalovirus retinitis in AIDS. Treatment with intravitreal injections of ganciclovir].
Cytomegalovirus (CMV) retinitis is the most frequent ocular infection in AIDS, and it is responsible for blindness. Intravitreal injections of ganciclovir in doses of 400 g have been tried in patients who could not tolerate any systemic treatment. Induction therapy consists of 2 injections per week, followed by maintenance therapy with 1 injection per week. The present study involved 17 patients. Twenty-three induction courses could be evaluated; all had a favourable response with an average of 6 injections per eye. Seventeen maintenance courses were evaluated, with a mean of 5 injections per eye. There was no relapse in 10 eyes (70 percent) at 48 days. There was no evidence of toxicity from repeated intravitreal injections: no cataract, retinal detachment or endophthalmitis was observed with a total of 231 injections. Intravitreal ganciclovir appears to be an effective local treatment of CMV retinitis in AIDS patients when systemic therapy cannot be used.
Cochereau-Massin
I
I
Service d'Ophtalmologie, Hôpital La Pitié-Salpêtrière, Paris.
Le Hoang
P
P
Lautier-Frau
M
M
Zazoun
L
L
Marcel
P
P
Robinet
M
M
Besingue
A
A
Rousselie
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003587:Cytomegalovirus; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012173:Retinitis / Q000188:drug therapy* / Q000209:etiology
D015774:Ganciclovir
Rétinite à cytomégalovirus au cours du SIDA. Traitement par injections intravitréennes de ganciclovir.