Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1.
Chromosome 1 with one or two long insertions has been previously found in natural mouse populations. The inheritance of chromosome 1 with two insertions from the Yakutsk population is analysed in this paper. It was demonstrated that heterozygous females transmit this chromosome to 80-85% of offspring. The observations made at M II, in conjunction with the recombination data, allowed us to conclude that preferential passage of the chromosome 1 with insertions to the oocyte and egg, rather than to the first and second polar bodies at meiosis, is the causative factor of the distorted segregation. A meiotic drive of such potency has not been previously reported for female mammals. The possible mechanism of the drive is discussed.
Agulnik
S I
SI
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Novosibirsk.
Agulnik
A I
AI
Ruvinsky
A O
AO
D000818:Animals; D004251:DNA Transposable Elements; D005260:Female; D005787:Gene Frequency; D008540:Meiosis; D051379:Mice / Q000235:genetics*
D004251:DNA Transposable Elements