The human alkaline phosphatases: what we know and what we don't know.
A review of the human alkaline phosphatases dealing specifically with (1) the gene loci, (2) characterization and discrimination of the various enzymes, (3) polymorphism at the enzyme level, (4) cDNA and gene structures, (5) membrane binding, (6) the carbohydrate moieties, (7) hypophosphatasia, (8) alkaline phosphatases in malignancies, (9) function.
Harris
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University of Pennsylvania, School of Medicine, Department of Human Genetics, Philadelphia 19104.
D000469:Alkaline Phosphatase / Q000235:genetics* / Q000502:physiology; D002241:Carbohydrates / Q000032:analysis; D002462:Cell Membrane / Q000378:metabolism; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D005796:Genes; D006801:Humans; D007014:Hypophosphatasia / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics* / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology*; D011110:Polymorphism, Genetic / Q000502:physiology*; D012689:Sequence Homology, Nucleic Acid
D002241:Carbohydrates; D007527:Isoenzymes; D004247:DNA; D000469:Alkaline Phosphatase