Remote, semiautomated production of 6-[18F]fluoro-L-dopa for human studies with PET.
Regioselective radiofluorodemercuration of the 6-mercurio derivative 5 with [18F]acetylhypofluorite afforded, after acidic hydrolysis, 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FD, 1) with a radiochemical yield of 11% (decay corrected and based on the total amount of [18F]F2 recovered from the target). 6-FD was obtained with a chemical and radiochemical purity of greater than 99% and with a level of mercury in the final preparation of less than 20 ppb. Utilization of a remote, semiautomated production system, resulted in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min.
Luxen
A
A
Department of Radiological Sciences, UCLA School of Medicine 90024.
Perlmutter
M
M
Bida
G T
GT
Van Moffaert
G
G
Cook
J S
JS
Satyamurthy
N
N
Phelps
M E
ME
Barrio
J R
JR
D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D006801:Humans; D007553:Isotope Labeling; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine