title: Nucleotide sequences of the VP1 capsid proteins of wild poliovirus types 1 and 3 from epidemic areas of Brazil.
abstract: The nucleotide sequences encoding the capsid protein VP1 were determined for the wild polioviruses of serotypes 1 and 3 endemic to the northeastern region of Brazil. Compared with the corresponding Sabin vaccine strain sequences, the wild isolates differed at 20% (type 1) and 22% (type 3) of their nucleotide positions, and in 7% (type 1) and 11% (type 3) of their amino acid residues. The highest degree of amino acid heterogeneity occurred within the amino-terminal residues of the VP1 proteins. Intratypic amino acid differences also occurred in VP1 surface residues that form parts of antigenic sites for neutralizing antibodies.
authors.affiliation: Departamento de Virologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: E E
authors.initials: EE
authors.lastname: Da-Silva
authors.forename: H G
authors.initials: HG
authors.lastname: Schatzmayr
authors.forename: O M
authors.initials: OM
authors.lastname: Kew
mesh_terms: D000940:Antigenic Variation / Q000235:genetics; D001483:Base Sequence; D001938:Brazil; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D005814:Genes, Viral / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D011051:Poliomyelitis / Q000635:transmission; D017955:Poliovirus / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D036022:Capsid Proteins; C442540:VP1 protein, Poliovirus