[The EPR spectra of the ribonucleotide reductase in the tumorous tissues and organs of tumor-bearing animals].
Ribonucleotide reductase activity (RRA) has been studied in various tumors and spleens of tumor-bearing animals using EPR technique and biochemical methods. The effect of a number of biologically active compounds on RRA has also been studied. RRA in tumor and spleen increases during tumor growth. Inhibitory effect of irradiation, hydroxyurea, nitrosomethylurea and activatory effect of 5-nitrofurans and nitroimidazole derivatives on RRA has been observed. Regulatory factors of RRA and DNA synthesis in vivo have been discussed.
Pulatova
M K
MK
Filatov
D E
DE
Sharygin
V L
VL
Gorbacheva
L B
LB
Gudtsova
K V
KV
Kuropteva
Z V
ZV
Zhumabaeva
T T
TT
Shamaev
V I
VI
Korman
D B
DB
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007939:Leukemia L1210 / Q000201:enzymology*; D007941:Leukemia P388 / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012264:Ribonucleotide Reductases / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D012511:Sarcoma 37 / Q000201:enzymology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D013997:Time Factors
D012264:Ribonucleotide Reductases
Spektry EPR ribonukleotidreduktazy v opukholevykh tkaniakh i organakh zhivotnykh-opukholenositeleĭ.