[Antagonism of verapamil on the injurious action of endothelin of isolated rat heart].
Isolated rat hearts perfused with endothelin at a concentration of 10(-8) mol/L showed serious functional and cellular myocardial deterioration as manifested by a significant increase of mean perfusion and left ventricular pressure, decrease of +/- LV dp/dtmax, leakage of myocardial protein, formation of lipid peroxides, increase of myocardial calcium content, etc. Calcium channel blocker, verapamil, effectively antagonized the injurious action of endothelin on rat heart whether administered along with or after endothelin perfusion.
Tang
C S
CS
Department of Pathophysiology, Beijing Medical University.
Li
Z P
ZP
Tang
J
J
Su
J Y
JY
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D016232:Endothelins / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000037:antagonists & inhibitors*
D015220:Calcium Channels; D016232:Endothelins; D014700:Verapamil