title: Environmental stimuli and transcriptional activity generate transient changes in DNA torsional tension.
abstract: Transient changes in DNA torsional tension are generated by environmental stimuli and transcriptional activity. In eukaryotic cells, these changes can only be accommodated by a chromatin structure that is flexible. This property of chromatin may be essential to the regulation of eukaryotic gene activity.
authors.affiliation: Laboratory for the Study of Skeletal Disorders, Children's Hospital, Boston, MA 02115.
authors.forename: R A
authors.initials: RA
authors.lastname: Saavedra
mesh_terms: D002843:Chromatin / Q000502:physiology* / Q000648:ultrastructure; D004247:DNA / Q000235:genetics* / Q000648:ultrastructure; D005786:Gene Expression Regulation; D009690:Nucleic Acid Conformation; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004247:DNA