Dissecting the complexity of the nervous system by enhancer detection.
Enhancer detectors are DNA constructs which, when introduced into a eukaryotic genome, respond to nearby genomic transcriptional regulatory elements by means of a reporter gene, revealing the expression pattern of genes in their vicinity. Recent experiments in Drosophila suggest that enhancer detection is a powerful method to identify genes that are expressed in the nervous system. Since enhancer detectors allow a rapid molecular and genetic characterization of genes in their vicinity, the method will greatly facilitate the study of neural development and behavior.
Bellen
H J
HJ
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.
Wilson
C
C
Gehring
W J
WJ
D000818:Animals; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster; D004742:Enhancer Elements, Genetic; D015870:Gene Expression; D005821:Genetic Techniques; D009420:Nervous System / Q000196:embryology; D009424:Nervous System Physiological Phenomena
D004251:DNA Transposable Elements