Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease.
Hexokinase, lactate dehydrogenase, acylphosphatase, (Na+,K+)-ATPase and Ca2(+)-ATPase of selected areas from postmortem Alzheimer's disease brains were studied. Hexokinase and lactate dehydrogenase were significantly changed in all the examined subcortical nuclei. (Na+,K+)-ATPase activity was altered in several areas of Alzheimer's disease brains. No changes in Ca2(+)-ATPase and acylphosphatase were observed. The main alterations of the assayed enzymes were observed in subcortical areas but not in cortical areas of Alzheimer's disease brains.
Liguri
G
G
Department of Biochemical Sciences, University of Florence, Italy.
Taddei
N
N
Nassi
P
P
Latorraca
S
S
Nediani
C
C
Sorbi
S
S
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D006593:Hexokinase / Q000378:metabolism*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase