title: Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo.
abstract: The present report investigates the modulation of the hypothalamic-pituitary-adrenal (HPA) axis in the rat by sigma receptors, using a selective ligand, (+) pentazocine, and comparing the effects with (+) SKF 10, 047. Both compounds stimulate ACTH release potently after central and peripheral administration. These effects are centrally mediated, since they did not release ACTH from anterior pituitary primary cultures. The effects are not blocked by naloxone, but are blocked by the NMDA antagonist, CPP, indicating a centrally mediated functional interaction between NMDA and sigma receptors, in vivo.
authors.affiliation: CNS Diseases Research, G. D. Searle and Company, St. Louis, MO 63198.
authors.forename: S
authors.initials: S
authors.lastname: Iyengar
authors.forename: S
authors.initials: S
authors.lastname: Mick
authors.forename: V
authors.initials: V
authors.lastname: Dilworth
authors.forename: J
authors.initials: J
authors.lastname: Michel
authors.forename: T S
authors.initials: TS
authors.lastname: Rao
authors.forename: J M
authors.initials: JM
authors.lastname: Farah
authors.forename: P L
authors.initials: PL
authors.lastname: Wood
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002478:Cells, Cultured; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D016202:N-Methylaspartate; D010423:Pentazocine / Q000494:pharmacology; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000502:physiology*; D017480:Receptors, sigma
chemical_list: D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D017480:Receptors, sigma; D001224:Aspartic Acid; D016202:N-Methylaspartate; C012134:SK&F 10047; D000324:Adrenocorticotropic Hormone; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; D010620:Phenazocine; D010423:Pentazocine