title: Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt-Jakob disease.
abstract: Cerebellar kuru plaques in 2 cases of Creutzfeldt-Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin-positive, tau-negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt-Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.
authors.affiliation: Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
authors.forename: T
authors.initials: T
authors.lastname: Suenaga
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: J F
authors.initials: JF
authors.lastname: Llena
authors.forename: H
authors.initials: H
authors.lastname: Ksiezak-Reding
authors.forename: S H
authors.initials: SH
authors.lastname: Yen
authors.forename: D W
authors.initials: DW
authors.lastname: Dickson
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000737:chemistry* / Q000648:ultrastructure; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D014452:Ubiquitins / Q000032:analysis*
chemical_list: D014452:Ubiquitins