Histological changes in glioblastoma after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon.
Seven glioblastomas were studied between 1 and 6 months after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon. Morphological study showed a great number of lymphocytes within the tumor tissue, and interactions between lymphocytes and glioblastoma cells, suggesting a killing phenomenon. These data support the potential usefulness of adoptive immunotherapy in patients with glioblastoma by means of intratumoral administration of activated lymphoid cells.
Vaquero
J
J
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Coca
S
S
Oya
S
S
Martínez
R
R
Regidor
C
C
Barbolla
L
L
Salazar
F G
FG
Ramiro
J
J
D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007267:Injections; D007370:Interferon Type I / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000473:pathology; D007694:Killer Cells, Natural / Q000473:pathology; D008214:Lymphocytes
D007370:Interferon Type I