Superoxide scavenging properties of flavonoids in a non-enzymic system.
The superoxide anion scavenging activity of 38 flavonoids, some of them isolated from Sideritis mugronensis, Sideritis javalambrensis and Cayaponia tayuya were investigated by measurement of their inhibition of nitroblue tetrazolium reduction. Isoorientin, orientin, amentoflavone, leucocyanidol, eriodictyol, datiscetin and robinetin behaved as potent scavengers and structure-activity relationships were established.
Huguet
A I
AI
Departament de Farmacologia i Farmacotècnia, Facultat de Farmacia, Valencia, Spain.
Máñez
S
S
Alcaraz
M J
MJ
D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007700:Kinetics; D009580:Nitroblue Tetrazolium; D010944:Plants; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*; D013481:Superoxides
D005419:Flavonoids; D013481:Superoxides; D009580:Nitroblue Tetrazolium; D013482:Superoxide Dismutase