[The effect of high molecular weight interferon inducers (dsRNA) on virus adsorption].
Interrelationship between phosphorylation of plasmatic membrane proteins in brain cells and the rate of mice encephalomyocarditis virus adsorption was studied. Phosphorylation of proteins induced by dsRNA (laryphane) was most distinctly manifested in membrane fraction and cytosol of rat brain neuronal cells. Similarity of molecular mass spectra in dsRNA- and cAMP-dependent phosphorylation enabled to suggest that dsRNA activated protein kinase. An increase in the rate of plasmatic membrane proteins phosphorylation appears to correlate with inhibition of virus adsorption as shown by studies of these reactions dynamics. Under conditions of considerable increase in the rate of membrane proteins phosphorylation adsorption of virus on cells was distinctly inhibited.
Bakunts
K A
KA
Gevorkian
M G
MG
Tazulakhova
E B
EB
Zakharian
R A
RA
Ershov
F I
FI
D000327:Adsorption; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004686:Encephalomyocarditis virus / Q000187:drug effects* / Q000378:metabolism; D007369:Interferon Inducers / Q000494:pharmacology*; D007739:L Cells; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000494:pharmacology*
D007369:Interferon Inducers; D008565:Membrane Proteins; D012330:RNA, Double-Stranded; D011494:Protein Kinases
Vliianie vysokomolekuliarnykh induktorov interferona (dsRNK) na adsorbtsiiu virusa.