title: Noise and hypoxia induced temporary threshold shifts in rats studied by ABR.
abstract: Rats were exposed for 2 h either to 115 dB SPL noise, to 5% oxygen in nitrogen (hypoxia) or to both hypoxia and noise. Auditory nerve-brainstem evoked responses (ABR) to 80 dB HL clicks and threshold were recorded prior to exposure, immediately (5-10 min) after the exposure, 2 h after and 2 weeks after the exposure. The findings in each experimental animal were compared to those in the control (non-exposed) group and to those in the other groups. Thresholds were elevated in each of the experimental groups, but these were temporary threshold shifts, since 2 weeks following the exposure, threshold had returned to normal. Latencies (wave I and the IV-I interpeak latency difference- (IPLD] were prolonged in the groups exposed to hypoxia (hypoxia alone and hypoxia + noise). These results are discussed in view of possible mechanisms of these noise and hypoxia induced temporary threshold shifts.
authors.affiliation: Institute for Noise Hazards Research, Medical Corps, Israel Defence Forces, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan.
authors.forename: J
authors.initials: J
authors.lastname: Attias
authors.forename: H
authors.initials: H
authors.lastname: Sohmer
authors.forename: S
authors.initials: S
authors.lastname: Gold
authors.forename: I
authors.initials: I
authors.lastname: Haran
authors.forename: A
authors.initials: A
authors.lastname: Shahar
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology / Q000503:physiopathology*; D004056:Differential Threshold; D005071:Evoked Potentials; D000860:Hypoxia / Q000503:physiopathology*; D009622:Noise; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012684:Sensory Thresholds; D009435:Synaptic Transmission; D013997:Time Factors; D000159:Vestibulocochlear Nerve / Q000502:physiology / Q000503:physiopathology*