The action of N,N-diethyldithiocarbamate(DDC) on red blood cells.
Glutathione exerts a pro-oxidative effect by increasing H2O2-formation in the presence of methemoglobin and a radical-generating substance (e.g. DDC). This effect might contribute to the loss of glutathione in cells in which formation of methemoglobin is provoked by radicals.
Heumann
C
C
Institute of Biochemistry, Humboldt University, Berlin, GDR.
Dumdey
R
R
Müller
M
M
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects*; D005609:Free Radicals; D005978:Glutathione / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000494:pharmacology*; D010101:Oxygen Consumption; D011817:Rabbits
D005609:Free Radicals; D008706:Methemoglobin; D004050:Ditiocarb; D006861:Hydrogen Peroxide; D002374:Catalase; D005978:Glutathione