title: Cyclic CMP (cytidine 3',5'-monophosphate) suppresses changes in human sperm amplitude of lateral head displacement and hyperactivation.
abstract: The dibutyryl analog of cCMP suppressed sperm amplitude of lateral head displacement and hyperactivation. Sperm motility was inhibited by dibutyryl cCMP with a shift toward less linear trajectory sperm movements. The results suggest a role of cCMP as an inhibitory signal on sperm motility patterns related to sperm capacitation.
authors.affiliation: Dept of Gynecology and Obstetrics, Loma Linda University School of Medicine, California 92354.
authors.forename: P J
authors.initials: PJ
authors.lastname: Chan
authors.forename: D R
authors.initials: DR
authors.lastname: Tredway
authors.forename: I
authors.initials: I
authors.lastname: Henig
authors.forename: S G
authors.initials: SG
authors.lastname: Prough
mesh_terms: D000242:Cyclic AMP / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D013075:Sperm Capacitation / Q000187:drug effects; D013077:Sperm Head / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D000242:Cyclic AMP