title: [Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction].
abstract: In the last decades new approaches to the diagnosis and treatment of Hodgkin's Disease (HD) have contributed to improved rates of survival and cure but the pathogenesis of the disease still remains unknown. Data have been collected suggesting a relationship between viral infections and HD. HD patients with evidence of Epstein-Barr virus genomes in their affected tissues have been recently reported. Human Herpes Virus six (HHV-6) is a newly isolated virus, derived from patients with lymphoproliferative disorders. In order to investigate the possible role of this virus in the pathogenesis of HD we looked for a specific segment of HHV-6 genome by means of the polymerase chain reaction (PCR) in tissue samples obtained from peripheral blood and lymphnodes in HD patients: one clearly positive case has been identified. This result is the first indication of HHV-6 sequences associated with a case of HD and raises the possibility that this virus might be involved in the pathogenesis of this lymphoproliferative disorder. The relationship between HHV-6 and HD therefore warrants further investigation.
authors.affiliation: Istituto di Clinica Medica II, Università di Modena.
authors.forename: R
authors.initials: R
authors.lastname: Marasca
authors.forename: M
authors.initials: M
authors.lastname: Luppi
authors.forename: M
authors.initials: M
authors.lastname: Montorsi
authors.forename: M
authors.initials: M
authors.lastname: Fancinelli
authors.forename: R
authors.initials: R
authors.lastname: Sabbatini
authors.forename: M T
authors.initials: MT
authors.lastname: Mariano
authors.forename: L
authors.initials: L
authors.lastname: Selleri
mesh_terms: D004279:DNA, Viral / Q000032:analysis; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral
vernacular_title: Identificazione di sequenze del virus erpetico umano HHV-6 in un caso di malattia di Hodgkin mediante reazione polimerasica a catena.