Interactions of phencyclidine receptor agonist MK-801 with dopaminergic system: regional studies in the rat.
Interactions of the potent phencyclidine receptor agonist MK-801 with the dopaminergic system were examined in various brain regions in the rat. MK-801 increased dopamine (DA) metabolism in the pyriform cortex, entorhinal cortex, prefrontal cortex, striatum, olfactory tubercle, amygdala, and septum without affecting DA metabolism in the cingulate cortex and nucleus accumbens. In pyriform cortex and amygdala, MK-801 was more potent than phencyclidine at increasing DA metabolism. Local injections of MK-801 into ventral tegmental area and into the amygdala/pyriform cortex interface indicated that MK-801 may act at the cell body as well as the nerve terminal level to increase DA metabolism and that ongoing dopaminergic neuronal activity is a prerequisite for full drug action.
Rao
T S
TS
Research Department, Ciba-Geigy Pharmaceuticals Division, Summit, New Jersey.
Kim
H S
HS
Lehmann
J
J
Martin
L L
LL
Wood
P L
PL
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism; D010622:Phencyclidine / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D017478:Receptors, Phencyclidine; D014018:Tissue Distribution
D003986:Dibenzocycloheptenes; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D015102:3,4-Dihydroxyphenylacetic Acid; D016291:Dizocilpine Maleate; D010622:Phencyclidine; D004298:Dopamine; D006719:Homovanillic Acid