Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea.
The reliability of saliva as an indicator of rotavirus infection was assessed among 15 infants (3-12 months) with rotaviral and 15 with nonrotaviral diarrhea. Paired salivary samples collected during acute and convalescent phases were tested for rotavirus-specific IgA and IgM by an ELISA. The sensitivity of IgA or IgM alone to predict infection was 53.3% and 46.6%, respectively; used in conjunction, the sensitivity rose to 80%. It seems that infants with rotaviral diarrhea mount mucosal antibody responses as reflected in their saliva; possibly salivary antibodies could be used to evaluate vaccine "take" in rotavirus vaccine trials.
Aiyar
J
J
Department of Pediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi.
Bhan
M K
MK
Bhandari
N
N
Kumar
R
R
Raj
P
P
Sazawal
S
S
D000914:Antibodies, Viral / Q000096:biosynthesis*; D003968:Diarrhea, Infantile / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007223:Infant; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology*; D012463:Saliva / Q000276:immunology*
D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M