Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis.
We assessed 33 lymphoid tissues from 15 patients, including 7 with X-linked lymphoproliferative disease (XLP) and 8 patients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immunophenotype and expressed Epstein-Barr virus (EBV)-encoded proteins characteristic of either EBV-immortalized lymphoblastoid cell lines (LCL) or EBV-carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL-like, and in 2 cases they were monoclonal, malignant lymphoma-like.
Falk
K
K
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Ernberg
I
I
Sakthivel
R
R
Davis
J
J
Christensson
B
B
Luka
J
J
Okano
M
M
Grierson
H L
HL
Klein
G
G
Purtilo
D T
DT
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology* / Q000382:microbiology; D015139:Blotting, Southern; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D016130:Immunophenotyping; D007223:Infant; D007244:Infectious Mononucleosis / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D014764:Viral Proteins / Q000096:biosynthesis*
D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins