[The regulation of Na, K-ATPase activity by the substrate].
The mechanism of functioning of Na, K-ATPase system is considered, the peculiarities of hydrolysis in different substrates are described. The experimental results testify to the role of substrate structure in E2----E1-transition, Na+ transport, K(+)-dependent phosphatase activity and quaternary structure of enzyme. The regulatory role of molecular organization of Na, K-ATPase in ion transport is discussed.
Boldyrev
A A
AA
Lopina
O D
OD
Fedosova
N U
NU
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006868:Hydrolysis; D008970:Molecular Weight; D009711:Nucleotides / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity / Q000502:physiology
D009711:Nucleotides; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase
Reguliatsiia aktivnosti Na, K-ATFazy substratom.