Is the corpus luteum normal after ovulation induction?
Repeated ultrasound examinations and blood samplings for determination of estradiol (E), progesterone (P), and luteinizing hormone (LH) were carried out in 15 normal and 11 clomiphene citrate (CC)/human menopausal gonadotropin (hMG) stimulated cycles. Human chorionic gonadotropin (hCG) was administered in the stimulated cycles on the day of the expected LH-peak as determined in each woman's normal cycle. Ovulation and normalcy of the luteal phase were confirmed by the hormonal values. Ultrasound examinations showed development of a single follicle in the normal group and development of 4.1 follicles on average, of 15 mm or more in diameter in the stimulated group (total of 45 follicles). Midluteal phase images at the site of the former follicle showed echogenic structures of echo-free structures with scattered echoes in 25 cases in the stimulated group and in 11 cases in the normal group. There was no sign of the former follicle in 1 and 3 cases, respectively, in the two groups. A significantly higher number of "persistent follicles" was seen in the stimulated group: 42% vs. 7%. It is discussed whether a compromised corpus luteum function occurs after stimulation despite a normal luteal phase.
Lenz
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S
Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.
Lindenberg
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S
D002996:Clomiphene / Q000627:therapeutic use; D003338:Corpus Luteum / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008183:Luteal Phase; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D014463:Ultrasonography
D002996:Clomiphene; D008596:Menotropins