title: Breast biopsy for calcifications in nonpalpable breast lesions. A prospective study.
abstract: We prospectively studied 239 consecutive patients who underwent breast biopsy for 277 nonpalpable lesions characterized by mammographic microcalcifications. Clinical and mammographic characteristics were correlated with histologic findings in an attempt to identify patients more likely to have early breast cancer. The distribution of clinical risk factors was equal between patients with benign or malignant outcomes. The predominant Wolfe pattern on mammography was P2 (38%); however, no relationship was observed between the Wolfe pattern and malignancy. A marked correlation was observed between malignancy and small lesions, more than 15 calcifications, and calcifications in a linear or branching pattern. Twenty-four percent (n = 67) of the biopsy specimens contained either ductal or lobular breast cancer. This study highlights the necessity of an aggressive approach toward suspicious calcifications found by mammography.
authors.affiliation: University Hospitals of Cleveland, Case Western Reserve University, OH 44106.
authors.forename: D
authors.initials: D
authors.lastname: Franceschi
authors.forename: J
authors.initials: J
authors.lastname: Crowe
authors.forename: R
authors.initials: R
authors.lastname: Zollinger
authors.forename: R
authors.initials: R
authors.lastname: Duchesneau
authors.forename: R
authors.initials: R
authors.lastname: Shenk
authors.forename: G
authors.initials: G
authors.lastname: Stefanek
authors.forename: J M
authors.initials: JM
authors.lastname: Shuck
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology; D002278:Carcinoma in Situ / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D016037:Single-Blind Method