title: Effect of long-term treatment with massive doses of 1 alpha-hydroxyvitamin D3 on calcium-phosphate balance in patients with vitamin D-dependent rickets type II.
abstract: Three patients with vitamin D-dependent rickets type II were given massive doses of 1 alpha-hydroxyvitamin D3 for 29 to 36 months and their calcium-phosphate balance was studied during treatment and one month after cessation of treatment. During treatment fasting hypercalciuria was observed in patient 1 and an increased rate of calcium excretion after calcium loading in patients 1 and 2. In these patients, calcium excretion was parallel with the serum 24,25-dihydroxyvitamin D concentration, which may reflect the level of receptor for 1,25-dihydroxyvitamin D. These findings suggested that the responsiveness to 1,25-dihydroxyvitamin D improved during long-term treatment of these two patients with vitamin D-dependent rickets type II.
authors.affiliation: Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Takeda
authors.forename: I
authors.initials: I
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Saijo
authors.forename: I
authors.initials: I
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007015:Hypophosphatemia, Familial / Q000188:drug therapy* / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006887:Hydroxycholecalciferols; D010710:Phosphates; D002118:Calcium; C008088:alfacalcidol