[The role of congenital Enterovirus infection in the pathogenesis of suppurative and inflammatory diseases in newborn infants].
Newborns with suppurative-inflammatory disease were found to be at high risk of intrauterine infection with Coxsackie enteroviruses from mothers with persistent enterovirus infection; in 54.9%, congenital Coxsackie virus infection was confirmed by virus antigen identification in the urine sediment cells and autopsy material. Coxsackie A viruses were identified in 68.7% of sepsis cases, 42.6% with local purulent infection foci, and in only 6.7% of practically healthy neonates. Specific features of the clinical course are analysed together with the pathohistological picture of congenital enterovirus infection associated with the vertical virus transmission from the mother having a persistent form of this infection. A suggestion is proposed that the severe course of suppurative-inflammatory conditions and the general character of neonatal bacterial infection are largely determined by the immunodeficient states which are etiologically related to congenital enterovirus infections.
Lozovskaia
L S
LS
Iatsyk
G V
GV
Kasimova
N B
NB
Sakhatov
M Ia
MIa
D003384:Coxsackievirus Infections / Q000151:congenital / Q000209:etiology*; D004770:Enterovirus / Q000472:pathogenicity*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000151:congenital / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008590:Meningoencephalitis / Q000151:congenital / Q000209:etiology*; D009205:Myocarditis / Q000151:congenital / Q000209:etiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*
Uchastie vrozhdennoĭ énterovirusnoĭ infektsii v patogeneze gnoĭno-vospalitel'nykh zabolevaniĭ u novorozhdennykh.