Beta-adrenergic regulation of gastrin release from gastrinoma cells.
The effect of epinephrine on the plasma gastrin level was investigated in three patients with Zollinger-Ellison syndrome (ZES) and in 14 normal subjects. Two ZES patients had undergone total gastrectomy, and the third had undergone subtotal gastrectomy before our study. A significant increase in plasma gastrin, from 23 +/- 5 pg/ml to 53 +/- 20 pg/ml, in response to intravenous epinephrine (40 ng/kg.min), was observed in the normal subjects. This response was completely abolished by beta-blockade. In the ZES patients, epinephrine (40 ng/kg.min) also resulted in an increase in the plasma concentration of gastrin. The basal and maximum concentrations of gastrin were 580 and 1680 pg/ml in patient 1, 145000 and 320000 pg/ml in patient 2, and 200 and 1800 pg/ml in patient 3, respectively. beta-Adrenergic blockade suppressed the epinephrine-stimulated gastrin release in these patients as well. Graded intravenous doses of epinephrine given to the ZES patients resulted in elevation of the plasma gastrin in a dose-dependent manner. Insulin hypoglycemia caused an increase in both plasma epinephrine and plasma gastrin in ZES patients and normal subjects. A significant correlation between plasma gastrin and epinephrine during insulin hypoglycemia was observed in both groups. Exercise, with use of a bicycle ergometer, resulted in an increase in plasma epinephrine. An increase in plasma gastrin with exercise was observed in the ZES patients, and this was also suppressed by beta-blockade. The results suggest that gastrinoma cells, like normal G cells, are equipped with beta-adrenergic receptors that regulate gastrin release.
Sakamoto
T
T
First Department of Surgery, Osaka University Medical School, Japan.
Miyata
M
M
Hamaji
M
M
Sakaguchi
H
H
Tanaka
Y
Y
Hashimoto
T
T
Kawashima
Y
Y
D000328:Adult; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D005260:Female; D015408:Gastrinoma / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism*
D005755:Gastrins; D011943:Receptors, Adrenergic, beta; D004837:Epinephrine