title: Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis.
abstract: The incidence of autoantibodies to glomerular basement membrane (AGBMA) and neutrophil cytoplasmic antigens (ANCA) in the initial sera of 889 consecutive patients with a suspected diagnosis of rapidly progressive glomerulonephritis, was determined by prospective study. Forty-seven (5%) were positive for AGBMA alone, 246 (28%) were positive for ANCA alone, 576 (65%) had neither autoantibodies while 20 (2%) had both. Clinical and pathological data collected from patients with both autoantibodies suggested the coexistence of anti-glomerular basement membrane disease and systemic vasculitis. Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.
authors.affiliation: Office of the Regius Professor of Physic, Clinical Medical School, Addenbrookes Hospital, Cambridge, United Kingdom.
authors.forename: D R
authors.initials: DR
authors.lastname: Jayne
authors.forename: P D
authors.initials: PD
authors.lastname: Marshall
authors.forename: S J
authors.initials: SJ
authors.lastname: Jones
authors.forename: C M
authors.initials: CM
authors.lastname: Lockwood
mesh_terms: D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011446:Prospective Studies; D011863:Radioimmunoassay; D014657:Vasculitis / Q000276:immunology
chemical_list: D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody