title: Superoxide generation by neutrophils after exposure to a conventional peritoneal dialysis solution for different time periods.
abstract: Neutrophils were isolated from canine blood and exposed to a conventional, acidic, lactate-containing peritoneal dialysis solution for 0, 2 and 4 minutes in one study and 0, 4, 7 and 10 minutes in another. Superoxide generation, expressed in nanomoles per million cells, was determined using a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Brief exposure of neutrophils to a conventional dialysis solution could significantly inhibit the generation of superoxide by neutrophils.
authors.affiliation: Veterans Administration Hospital, Hines, Illinois.
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: B L
authors.initials: BL
authors.lastname: Ing
authors.forename: F J
authors.initials: FJ
authors.lastname: Manahan
authors.forename: F Q
authors.initials: FQ
authors.lastname: Zhou
authors.forename: A W
authors.initials: AW
authors.lastname: Yu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Nawab
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
mesh_terms: D000818:Animals; D015314:Dialysis Solutions / Q000494:pharmacology*; D004285:Dogs; D007773:Lactates / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010530:Peritoneal Dialysis; D013481:Superoxides / Q000378:metabolism*; D013997:Time Factors
chemical_list: D015314:Dialysis Solutions; D007773:Lactates; D013481:Superoxides