title: [Cytomegalovirus (CMV) and human immunodeficiency virus (HIV) co-infection, of multinucleated giant cells in acquired immunodeficiency syndrome (AIDS) encephalopathy].
abstract: A 31-year-old HIV-1-seropositive Haitian male presented with HIV-nephropathy and typical features of subcortical dementia. He died 4 months after the onset of neurological signs. Neuropathological examination revealed HIV encephalitis with diffuse progressive leukoencephalopathy, diffuse poliodystrophy and massive calcifications of white matter, basal ganglia and dentate nuclei probably partly related to renal failure. It was associated with focal, subependymal CMV encephalitis. In the periventricular regions, morphologically characteristic multinucleated giant cells, positive for CD68, and negative for GFAP, contained early CMV antigens (E13) in their nuclei and HIV antigens (gp41 and p24) in their cytoplasm. The co-infection of a single cell by both viruses was confirmed by electron microscopy. The finding that HIV and CMV can co-infect in vivo the same cell raises the question of a direct cooperation of both viruses at the single cell level, and suggests the possibility of a role for CMV as co-factor in the pathogenesis of HIV encephalopathy.
authors.affiliation: Département de Pathologie Cellulaire et Tissulaire, Faculté de Médecine de Créteil.
authors.forename: L
authors.initials: L
authors.lastname: Belec
authors.forename: C
authors.initials: C
authors.lastname: Mhiri
authors.forename: D
authors.initials: D
authors.lastname: Belghiti
authors.forename: C
authors.initials: C
authors.lastname: Geny
authors.forename: P
authors.initials: P
authors.lastname: Boudes
authors.forename: F
authors.initials: F
authors.lastname: Gray
mesh_terms: D015526:AIDS Dementia Complex / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification*; D015726:Giant Cells / Q000382:microbiology* / Q000473:pathology; D006678:HIV / Q000302:isolation & purification*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male
vernacular_title: Co-infection par le cytomégalovirus (CMV) et le virus de l'immunodéficience humaine (VIH), de cellules géantes multinucléées, dans l'encéphalopathie du syndrome d'immunodéficience acquise (SIDA).