Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells.
Until recently, T cells were believed not to be involved in chronic myeloid leukemia. We describe an example of CML in T lymphoblastic crisis with massive generalized lymphadenopathy in which the blasts were CD2(+), CD5(+), and CD7(+), variably CD1(+) and CD3(+), and both responded to and could be induced to produce the T cell growth factor, interleukin-2. Additionally, the blasts were shown to contain the CML-related tyrosine kinase P210bcr-abl rather than the smaller kinase associated with Ph1(+) ALL. Finally, the participation of the T lymphoid lineage in the CML clone was proven by the presence of the same BCR rearrangement in blasts as in granulocytes, suggesting the existence of a bone marrow progenitor common to the T cell and myeloid lineages.
Schuh
A C
AC
Oncology Research, Toronto Hospital, Ontario.
Sutherland
D R
DR
Horsfall
W
W
Mills
G B
GB
Dube
I
I
Baker
M A
MA
Siminovitch
K
K
Bailey
D
D
Keating
A
A
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001752:Blast Crisis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000494:pharmacology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D015703:Antigens, CD; D007376:Interleukin-2; D011505:Protein-Tyrosine Kinases; D016044:Fusion Proteins, bcr-abl