Immunohistochemical distribution of CA19-9 in normal and tumor tissues of the kidney.
The immunohistochemical distribution of CA19-9 in normal and tumor tissue of the kidney was investigated. CA19-9 was detected in the cytoplasm and apical surface of renal proximal tubules, distal tubules and uroepithelium of the renal pelvis. Eight of 28 renal cell carcinomas (29%) expressed CA19-9. CA19-9 was also detected in 2 cases of transitional cell carcinoma and 1 of 4 cases of Wilm's tumor, but not in angiomyolipoma. As the measurement of CA19-9 is widely used to detect gastrointestinal carcinoma, the expression of CA19-9 in normal and neoplastic kidney tissue might have some clinical significance.
Ohshio
G
G
Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Ogawa
K
K
Kudo
H
H
Yamabe
H
H
Higuchi
K
K
Nakashima
Y
Y
Manabe
T
T
Tobe
T
T
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism*; D009396:Wilms Tumor / Q000378:metabolism
D015295:Antigens, Tumor-Associated, Carbohydrate