title: Disseminated intravascular coagulation after hepatic resection.
abstract: Disseminated intravascular coagulation (DIC) after hepatic resection is a serious complication that leads to a fatal outcome unless prompt treatment is instituted. Between April 1973 and June 1988, DIC occurred postoperatively in 18 of 192 patients who underwent hepatic resection because of a variety of diseases of the liver and biliary tract. The diagnosis was made on the basis of changes in platelet count, fibrinogen level, serum level of fibrin degradation product (FDP), and protamine sulfate test. Heparin was used in an earlier series but has been discontinued because of difficulty in determining the optimal dose in patients undergoing liver resection. Instead, we now use gabexate mesilate, which blocks the coagulation cascade without the aid of antithrombin III and works as an anticoagulant. Fifteen patients had uneventful recoveries, but three died. Two died of aggravation of DIC, which was a result of reoperation performed under the diagnosis of surgical bleeding. The other patient died of liver failure after fever of unknown cause persisted for 4 months. The rationale for the diagnosis and treatment of DIC after liver resection is documented, and the problems involved are discussed.
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: K
authors.initials: K
authors.lastname: Toyama
authors.forename: K
authors.initials: K
authors.lastname: Nakayasu
authors.forename: S
authors.initials: S
authors.lastname: Iida
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: A
authors.initials: A
authors.lastname: Toizumi
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001652:Bile Ducts / Q000601:surgery; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000601:surgery*; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011183:Postoperative Complications; D011479:Protamines
chemical_list: D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; D006146:Guanidines; D011479:Protamines; D016670:Gabexate; D006493:Heparin