title: Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma.
abstract: Binding characteristics of peripheral benzodiazepine binding sites (PBS) in membrane homogenates of samples taken at abdominal surgery from colonic adenocarcinoma and from healthy colonic tissues in 17 patients were determined. [3H]PK 11195, an isoquinoline carboxamide derivative, which exhibits high affinity to PBS, was used as a radioligand for the binding assay. A robust increase (3.1-fold) was found in membranes from the tumor sites as compared to normal control colon, whereas the affinity of [3H]PK 11195 to PBS was similar in both tissues.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
authors.forename: Y
authors.initials: Y
authors.lastname: Katz
authors.forename: A
authors.initials: A
authors.lastname: Eitan
authors.forename: M
authors.initials: M
authors.lastname: Gavish
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis*; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000032:analysis*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000032:analysis* / Q000502:physiology
chemical_list: D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195