Serum concentration of soluble interleukin-2 receptor as a sensitive parameter of disease activity in sarcoidosis.
We investigated the clinical value of measuring serum concentrations of soluble IL-2R in monitoring sarcoidosis. Serum concentrations of soluble IL-2R were measured in 70 patients with sarcoidosis. The mean value for active untreated sarcoidosis was 1,143 +/- 509 U/ml, while the normal range in 97 healthy control subjects was 80 to 300 U/ml. The mean value for active untreated sarcoidosis was significantly higher than that for dormant disease (353 +/- 183 U/ml) or that for corticosteroid-treated patients (380 +/- 151 U/ml). Serial changes in serum soluble IL-2R level were studied in cases of spontaneous remission or in corticosteroid-treated patients; a good correlation was noted between the changes in serum level of soluble IL-2R and clinical status. A positive correlation was noted between serum concentration of soluble IL-2R and serum ACE activity. These data confirmed that measurement of serum concentration of soluble IL-2R could be used in monitoring the disease activity in sarcoidosis.
Keicho
N
N
Third Department of Internal Medicine, University of Tokyo, Japan.
Kitamura
K
K
Takaku
F
F
Yotsumoto
H
H
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012507:Sarcoidosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy
D015415:Biomarkers; D015375:Receptors, Interleukin-2; D011239:Prednisolone; D007703:Peptidyl-Dipeptidase A