title: The effects of 3-deazaguanine on Rous sarcoma virus transformation.
abstract: An expression of cellular transformation in chicken embryo fibroblast infected with Rous sarcoma virus (RSV) was inhibited by 3-deazaguanine (3-DG). Re-transformation of normal rat kidney cells infected with a temperature-sensitive mutant of RSV was suppressed by 3-DG when the cells were shifted from the non-permissive temperature (38 degrees C) to the permissive temperature (33 degrees C). Removal of the inhibitor enabled the cells to revert to the transformed state. Finally, 3-DG had little or no effect on replication of RSV in the chicken embryo fibroblast cells.
authors.affiliation: Center for Advanced Medical Technology, San Francisco State University, California.
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: L A
authors.initials: LA
authors.lastname: Liu
authors.forename: K A
authors.initials: KA
authors.lastname: Borchardt
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects*; D002415:Cats; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013696:Temperature
chemical_list: D000998:Antiviral Agents; D006147:Guanine; C010567:3-deazaguanine