[Structural effects in membranes after exposure to methyl (embiquin) and metaxylyl derivatives of chloroalkylamines].
Chloroaklylamine derivatives are studied for their effect on the structural organization of mitochondrion and microsome membranes of the cattle liver. The antitumoural preparation--embiquin is shown to increase microviscosity of hydrophobic zones of a lipid matrix of mitochondrial membranes and to decrease the quantity of immobilized cytochrome C, whereas it has no effect on microsomal membranes. It is established that the replacement of a methyl substituent in the nitrogen atom of chloroalkylamines by the metaxylyl one evokes no qualitative differences in the character of disturbances of the structural properties of mitochondrial membranes, however it induces structural perturbations in the microsomal membranes.
Lebed'
O I
OI
Zhirnov
V V
VV
Primak
R G
RG
Braver-Chernobul'skaia
B S
BS
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002417:Cattle; D003574:Cytochrome c Group / Q000378:metabolism; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008466:Mechlorethamine / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000187:drug effects / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D014783:Viscosity
D000970:Antineoplastic Agents; D003574:Cytochrome c Group; D008563:Membrane Lipids; D008565:Membrane Proteins; D009588:Nitrogen Mustard Compounds; D012709:Serum Albumin; C065623:1,3-xylyl-di-(2-chloroethyl)amine; D008466:Mechlorethamine
Strukturnye éffekty v membranakh pri vozdeĭstvii metil'nogo (émbikhin) i metaksil'nogo proizvodnykh khloralkilaminov.