[A cloned protein belonging to the G protein-coupled receptor family has an essentially striatal distribution copying that of the major component of the D1 receptor].
RDC8 (correction of RCD8), a recently cloned new putative member of the G protein-coupled receptor family protein, is exclusively present in the medium-sized neurons of the striatum. This restricted localisation mimics the major striatal dopamine D1 receptor localisation and is of major importance for the understanding of basal ganglia physiology and degenerative diseases pathogeny such as Huntington's and Parkinson's disease. RDC7, another putative G protein-coupled receptor chemically closely related to RDC8 (correction of RCD8), is mainly distributed in pyramidal neurons of the cerebral cortex, the hippocampus and the claustrum, and in the amygdala, and may represent the minor extra-striatal variant of the D1 receptor.
Vanderhaeghen
J J
JJ
Laboratoire de Neuropathologie, Hôpitaux Brugmann, Erasme.
Schiffmann
S
S
Libert
F
F
Vassart
G
G
Dumont
J
J
D000818:Animals; D003001:Cloning, Molecular; D003342:Corpus Striatum / Q000032:analysis*; D004285:Dogs; D019204:GTP-Binding Proteins / Q000032:analysis*; D015335:Molecular Probes; D009479:Neuropeptides / Q000032:analysis; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D011954:Receptors, Dopamine / Q000032:analysis; D018047:Receptors, Purinergic P1
D015335:Molecular Probes; D009479:Neuropeptides; D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D018047:Receptors, Purinergic P1; C027460:dopamine-I receptor; C065666:purinoceptor RDC7; C065665:purinoceptor RDC8; D019204:GTP-Binding Proteins
Une protéine clonée appartenant à la famille des protéines couplées aux protéines G, a une distribution essentiellement striatale imitant celle de la composante majeure des récepteurs D1.