title: Simultaneous infection with human herpesvirus-6 and measles virus in infants.
abstract: Two infants (4 and 5 months of age) with a febrile episode for 3 and 5 days, respectively, developed skin rashes after the fever subsided and were diagnosed as exanthem subitum. The rash continued for 5 days followed by mild-to-moderate pigmentation. Human herpesvirus-6 and measles virus, which were confirmed by a specific immunofluorescence assay and by electron microscopy, were isolated simultaneously from blood in the acute stage of the disease but not from the convalescent stage. The titer of the herpesvirus-6 in blood was greater than that of measles. Specific serologic assays showed marked seroconversion against human herpesvirus-6 but not to measles virus. The results suggest that dual infection with human herpesvirus-6 and measles virus results in atypical exanthem subitum or modified measles with unique immunologic responses.
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suga
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Yazaki
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D005077:Exanthema Subitum / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D005312:Fetal Blood / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008457:Measles / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008459:Measles virus / Q000302:isolation & purification / Q000648:ultrastructure