title: Experimental primary postnatal bovine viral diarrhea viral infections in six-month-old calves.
abstract: Eight clinically healthy calves were inoculated intranasally, four with either noncytopathic or four with cytopathic bovine viral diarrhea virus, and were necropsied 5 or 12 days post-inoculation. The most frequent gross lesion associated with noncytopathic or cytopathic viral infection was proximal colonic mural edema. Consistent microscopic findings were acute to subacute tracheitis, mild enterocolitis with edema, petechial hemorrhages of mesenteric lymph nodes with mild follicular lymphocytic depletion, and paracortical lymphocytic hyperplasia. At necropsy, cytopathic virus was recovered from 4/4 calves and noncytopathic virus was isolated from 2/4 calves. Neutralizing antibodies to noncytopathic bovine viral diarrhea virus were detected in the two calves from which noncytopathic virus was not recovered. Immunohistochemical analysis of lymphoid tissues demonstrated a small, randomly distributed population of mononuclear cells that contained bovine viral diarrhea viral antigen in 7/8 calves.
authors.affiliation: Department of Veterinary Pathology, Iowa State University, Ames.
authors.forename: C L
authors.initials: CL
authors.lastname: Wilhelmsen
authors.forename: S R
authors.initials: SR
authors.lastname: Bolin
authors.forename: J F
authors.initials: JF
authors.lastname: Ridpath
authors.forename: N F
authors.initials: NF
authors.lastname: Cheville
authors.forename: J P
authors.initials: JP
authors.lastname: Kluge
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000382:microbiology / Q000473:pathology*; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D003106:Colon / Q000473:pathology; D001908:Diarrhea Viruses, Bovine Viral / Q000502:physiology; D007150:Immunohistochemistry; D007958:Leukocyte Count / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008221:Lymphoid Tissue / Q000382:microbiology; D014132:Trachea / Q000473:pathology; D014779:Virus Replication