title: Cytomegalovirus infections in thalassemic patients after bone marrow transplantation.
abstract: We report the incidence of cytomegalovirus (CMV) seroconversion, infections and mortality in 169 consecutive thalassemic patients transplanted in Pesaro. We observed a 44% incidence of early seroconversion and a 52% incidence of late seroconversion. No relationship was found between seroconversion and acute or chronic graft-versus-host disease (GVHD) or rejection. The donor status did not influence the incidence of seroconversion, GVHD and rejection. Only three patients died of CMV infection (1.7%); in each case CMV disease was the final cause of death in patients with severe acute GVHD.
authors.affiliation: Divisione ematologica e Centro trapianto di midollo osseo di Muraglia, Ospedale di Pesaro, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Baronciani
authors.forename: E
authors.initials: E
authors.lastname: Angelucci
authors.forename: G
authors.initials: G
authors.lastname: Lucarelli
authors.forename: M
authors.initials: M
authors.lastname: Galimberti
authors.forename: P
authors.initials: P
authors.lastname: Polchi
authors.forename: S M
authors.initials: SM
authors.lastname: Durazzi
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D013789:Thalassemia / Q000150:complications / Q000601:surgery*; D065227:Transfusion Reaction
chemical_list: D000914:Antibodies, Viral