[Monoclonal integration of simian T-cell leukemia virus in hamadryas with malignant lymphoma].
The association of simian T-cell leukemia virus with baboons malignant lymphoma was studied. Proviral DNA integrated in cells of lymphoid organs was detected in 19 of 21 sick animals examined. Only 4 of 10 monkeys from high risk colony without clinical manifestations had virus-specific sequences in their cellular DNAs. As a rule, S(H)TLV-I-infected cells monoclonally proliferated both in lymphomatous and healthy baboons. The restriction patterns with EcoRI, HindIII, PstI, BamHI of S(H)TLV-I provirus were similar but not identical to those of prototype HTLV-I and STLV-I isolates.
D'iachenko
A G
AG
Kondzhariia
I G
IG
Indzhiia
E V
EV
Lapin
B A
BA
Iakovleva
L A
LA
Rudaia
L D
LD
Dzhalagoniia
B L
BL
D000818:Animals; D004279:DNA, Viral / Q000235:genetics; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII; D015368:Human T-lymphotropic virus 1; D008223:Lymphoma / Q000382:microbiology / Q000662:veterinary*; D008992:Monkey Diseases / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D010215:Papio / Q000382:microbiology; D011995:Recombination, Genetic; D015301:Retroviruses, Simian / Q000235:genetics*; D015303:Simian T-lymphotropic virus 1 / Q000235:genetics*
D004279:DNA, Viral; D015245:Deoxyribonuclease BamHI; D015246:Deoxyribonuclease EcoRI; D015247:Deoxyribonuclease HindIII
Monoklonal'naia integratsiia virusa T-kletochnogo leĭkoza obez'ian u pavianov gamadrilov so zlokachestvennoĭ limfomoĭ.