[Animal experiment studies of the biocompatibility of colored and plain lens haptics of polymethylmethacrylate].
In spite of the great clinical success of cataract surgery and intraocular lens implantation, adverse reactions still occur. In 2-3% of all cases, there is acute or chronic inflammation. One reason might be that the biocompatibility of the lens material is insufficient. This study evaluates the biocompatibility of dyed and undyed transparent PMMA lens haptics. The haptics were implanted subcutaneously in mobile and immobile mice tissue. After different implantation periods varying from 1 week to 6 months, the haptics were removed and evaluated histologically. The undyed PMMA lens haptics showed no adverse reactions. The dyed PMMA lens haptics showed a strong inflammatory response caused by diffusion of the dye into the surrounding tissue.
Imkamp
E
E
Abteilung Pathologie, Zellkulturlabor, Neues Klinikum, Aachen.
Mittermayer
C
C
Hunold
W
W
D000818:Animals; D004396:Coloring Agents / Q000009:adverse effects*; D003238:Connective Tissue / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology*; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008768:Methylmethacrylates / Q000009:adverse effects*; D051379:Mice
D004396:Coloring Agents; D008768:Methylmethacrylates
Tierexperimentelle Untersuchungen zur Biokompatibilität von gefärbten und ungefärbten Linsenhaptiken aus Polymethylmethacrylat.