title: [Protein C, protein S and thrombomodulin: one of the natural antithrombotic mechanisms].
abstract: In this review paper, the salient features of the anticoagulant/fibrinolytic mechanism depending on coagulation protein C, protein S and thrombomodulin are reviewed. Coagulation protein C, activated at the endothelial cell surface in the presence of the complex thrombin/thrombomodulin exerts two anti-thrombotic effects: one anticoagulant dependent on the free protein S and the other pro-fibrinolytic, independent of protein S. Both inherited and acquired deficiencies of protein C and/or protein S lead to a thrombosis-prone state that has to be identified promptly to avoid vaso-occlusive episodes. The experience in Mexico with both the identification and treatment of these deficiencies is reviewed; it is interesting that we have found that patients with autoimmune disorders, mainly systemic lupus erythematosus and primary anti-phospholipid syndrome, have acquired deficiencies of this anticoagulant mechanism that may be related to the thrombogenesis observed in these patients.
authors.affiliation: Hospital Universitario de Puebla.
authors.forename: E
authors.initials: E
authors.lastname: Lobato-Mendizábal
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
mesh_terms: D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000503:physiopathology; D001777:Blood Coagulation / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008800:Mexico; D011486:Protein C / Q000502:physiology*; D020151:Protein C Deficiency; D017293:Protein S; D011956:Receptors, Cell Surface / Q000502:physiology*; D018179:Receptors, Thrombin; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology
chemical_list: D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin
vernacular_title: Proteína C, proteína S y trombomodulina: uno de los mecanismos antitrombóticos naturales.