[The effect of creatine phosphate on reflex transmission in the normal spinal cord and under hypoxic conditions].
The effect of phosphocreatine on reflex transmission in the spinal cord was studied in rats in vivo and in vitro. Low concentrations (10(-8)-10(-6) M) of phosphocreatine facilitated while high concentrations (10(-4)-10(-3) M) inhibited the amplitude of mono- and polysynaptic reflexes. It was found that phosphocreatine decreases the inhibiting action of hypoxia on test responses and accelerates restoration of the reflex transmission in the spinal cord.
Limanskiĭ
Iu P
IuP
Tamarova
Z A
ZA
Piliavskiĭ
A I
AI
Oksamitnyĭ
V N
VN
Khasabov
S G
SG
Bulgakova
N V
NV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D010725:Phosphocreatine / Q000494:pharmacology*; D051381:Rats; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D012023:Reflex, Monosynaptic / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D010725:Phosphocreatine
Vliianie kreatinfosfata na reflektornuiu peredachu v spinnom mozge v norme i v usloviiakh gipoksii.