Effect of endothelin-1 in man.
The effect of an intravenous infusion of human endothelin-1 on blood pressure and plasma concentrations of endothelin-1, potassium, sodium, renin, aldosterone, and atrial natriuretic factor was investigated in six healthy, sodium-loaded men. During the peptide's exogenous application (1.0, 2.5, and 5.0 ng/kg.min), its plasma concentrations rose from a basal value of 1.2 +/- 0.3 to 3.2 +/- 1.9, 9.9 +/- 7.6, and 56.5 +/- 50.3 pmol/l (p less than 0.01), respectively, and mean blood pressure rose from a basal value of 87.1 +/- 7.3 to 92.6 +/- 8.2 mm Hg (p less than 0.01). A rise in serum concentrations of potassium (from 4.0 +/- 0.3 to 4.6 +/- 0.2 mmol/l; p less than 0.005) and a concomitant fall in serum concentrations of sodium (from 142.7 +/- 1.0 to 139.5 +/- 2.3 mmol/l; p less than 0.05) was seen in each subject. Plasma concentrations of renin, aldosterone, and atrial natriuretic factor did not change during the infusion of endothelin-1. Thus, in the doses used, endothelin-1 induces a rise in blood pressure and serum potassium concentrations.
Vierhapper
H
H
I. Medizinische Universitätsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Wien, Austria.
Wagner
O
O
Nowotny
P
P
Waldhäusl
W
W
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins; D004730:Endothelium, Vascular; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009994:Osmolar Concentration; D010455:Peptides / Q000097:blood / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D011674:Pulse / Q000187:drug effects; D012964:Sodium / Q000097:blood
D016232:Endothelins; D010455:Peptides; D012964:Sodium; D011188:Potassium