Antimicrobial spectrum of cefpirome combined with tazobactam against the Bacteroides fragilis group.
Cefpirome, a so-called fourth-generation cephalosporin, was tested alone and in combination with the sulfone beta-lactamase inhibitor, tazobactam, against 63 members of the Bacteroides fragilis group. The cefpirome MIC50 was only 64 micrograms/ml, but the MIC was reduced eightfold with tazobactam (2:1 ratio). The addition of tazobactam to cefpirome or the use of metronidazole as a codrug appear to be alternative choices to enhance the antianaerobic spectrum. Over 98% of strains had cefpirome-tazobactam MICs of less than or equal to 32 micrograms/ml.
Jones
R N
RN
Anti-infective Research Center, University of Iowa Hospitals and Clinics, Iowa City.
Croco
J L
JL
Barrett
M S
MS
Novick
W J
WJ
Erwin
M E
ME
D001439:Bacteroides / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D010397:Penicillanic Acid / Q000494:pharmacology*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors; D000097572:Cefpirome
D002511:Cephalosporins; D010397:Penicillanic Acid; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors; D000097572:Cefpirome