title: Resorthiomycin, a novel antitumor antibiotic. I. Taxonomy, isolation and biological activity.
abstract: Resorthiomycin, a novel antitumor antibiotic, was isolated from the fermentation broth of a strain of Streptomyces collinus by ethyl acetate extraction, silica gel chromatography and HPLC. Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 micrograms/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. On the other hand, this antibiotic does not possess any antibacterial or antifungal activity.
authors.affiliation: Institute of Applied Microbiology, University of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Tahara
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: F
authors.initials: F
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Okabe
authors.forename: A
authors.initials: A
authors.lastname: Shimazu
authors.forename: A
authors.initials: A
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Yamaki
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D006528:Carcinoma, Hepatocellular; D002460:Cell Line / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007940:Leukemia L5178; D008113:Liver Neoplasms; D051379:Mice; D012118:Resorcinols / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000032:analysis
chemical_list: D000903:Antibiotics, Antineoplastic; D012118:Resorcinols; C063431:resorthiomycin