Endothelin receptors in cultured renal epithelial cells.
We demonstrated the presence of specific binding sites for endothelin in the renal epithelial cell lines. MDCK and LLC-PK1. Endothelin binding induced mobilisation of intracellular calcium, as shown by an increase in 45Ca2+ efflux. This suggests a direct effect of endothelin on renal reabsorption in addition to the effects on the renal vasculature.
Neuser
D
D
Institute of Pharmacology, Bayer AG, Wuppertal 1, F.R.G.
Zaiss
S
S
Stasch
J P
JP
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D002417:Cattle; D002460:Cell Line; D004847:Epithelial Cells; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin; D013552:Swine
D002132:Calcium Radioisotopes; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; D002118:Calcium