title: Pharmacokinetics, biodistribution and dosimetry of 99Tcm(V)DMSA in humans with squamous cell carcinoma.
abstract: Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. This study evaluated the pharmacokinetics and biodistribution of 99Tcm(V)DMSA in patients with SCC and calculated the bone mass of a New Zealand White (NZW) rabbit. This data was then used to calculate the effective dose equivalent in man. A total of 16 patients were studied (5 with no tumour, 11 with tumour). 99Tcm(V)DMSA had a fast bi-exponential blood clearance in patients with no tumour (30 and 401 min) and patients with tumour (30 and 387 min) with no significant difference (p greater than 0.05) between the two groups. 99Tcm(V)DMSA had a fast cumulative urine excretion with mean half-times in non-tumour and tumour patients of 183 min and 244 min respectively. There was no significant difference (p greater than 0.05) between these two latter groups. The effective dose equivalent of 99Tcm(V)DMSA in man is 5.1 microSv/MBq.
authors.affiliation: Department of Otolaryngology, Guy's Hospital, London.
authors.forename: J C
authors.initials: JC
authors.lastname: Watkinson
authors.forename: S
authors.initials: S
authors.lastname: Allen
authors.forename: C R
authors.initials: CR
authors.lastname: Lazarus
authors.forename: J
authors.initials: J
authors.lastname: Sinclair
authors.forename: G M
authors.initials: GM
authors.lastname: Blake
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D004113:Succimer / Q000493:pharmacokinetics*; D013438:Sulfhydryl Compounds / Q000493:pharmacokinetics*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer