title: Endocervical glandular dysplasia, adenocarcinoma in situ, and early invasive (microinvasive) adenocarcinoma of the uterine cervix.
abstract: The pathological features of endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS), and early invasive (microinvasive) adenocarcinoma are reviewed. The histology and histochemistry of normal endocervical epithelium is discussed. The association of human papillomavirus (HPV) with the precursor lesions of invasive adenocarcinoma is examined. In the section on AIS, particular areas discussed include topography, immunohistochemistry, ploidy, and differential diagnosis. A management plan for AIS, EGD, and AIS with early invasion is presented.
authors.affiliation: Department of Anatomical Pathology, I.C.P.M.R. Westmead Hospital, NSW Australia.
authors.forename: R C
authors.initials: RC
authors.lastname: Jaworski
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D002278:Carcinoma in Situ / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D002584:Cervix Uteri / Q000033:anatomy & histology / Q000378:metabolism; D004273:DNA, Neoplasm / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae; D011003:Ploidies; D014412:Tumor Virus Infections / Q000150:complications; D002578:Uterine Cervical Dysplasia / Q000378:metabolism / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm