The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus.
The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 microM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 microM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.
Harrison
N L
NL
Department of Anesthesia and Critical Care, University of Chicago, IL 60637.
Lovinger
D M
DM
Lambert
N A
NA
Teyler
T J
TJ
Prager
R
R
Ong
J
J
Kerr
D I
DI
D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*
D011963:Receptors, GABA-A; D001418:Baclofen; C057491:2-hydroxysaclofen