[The receptor binding of 3H-corticosterone and the dopamine content in the striatum of rats with a predisposition to audiogenic seizures].
The reactivity of hypophyseal-adrenocortical system, the receptor binding of 3H-corticosterone, and the catecholamines content in cerebral monoaminergic structures were studied in the Krushinskiĭ-Molodkina rats predisposed to audiogenic seizures and in control Wistar rats. No significant linear differences were found in these parameters in conditions of normal living activity. The hypophyseal-adrenocortical system of the Krushinskiĭ-Molodkina rats proved to be more responsive to auditory action. These animals revealed a higher dopamine content and a higher receptor binding of 3H-corticosterone in the striatum as compared with Wistar rats. The catecholamines and corticosteroids seem to interact in the process of regulation of the hypophyseal-adrenocortical system reactivity and of the function of nigrostriatal system when performing the organism response to a stimulus.
Rakitskaia
V V
VV
Garina
I A
IA
Lopatina
N G
NG
Pivina
S G
SG
Shaliapina
V G
VG
D000161:Acoustic Stimulation; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism*; D004198:Disease Susceptibility / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid; D012640:Seizures / Q000378:metabolism*; D014316:Tritium
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D014316:Tritium; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine
Retseptornoe sviazyvanie 3H-kortikosterona i soderzhanie dofamina v striatume krys s predraspolozhennost'iu k audiogennym sudorogam.