Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12.
The chromosomal location of the human ubiquitin genes has been evaluated by in situ hybridization. Because of the conservation of the ubiquitin sequence, coding-region probes cannot distinguish between specific ubiquitin genes and reveal ubiquitin sequences in a number of different chromosomal regions. The major sites of hybridization with a coding-region probe include 17p11.1-p12, 12p24.2-q24.32, and 2q21-q24, with weaker hybridization over 1p3, 1q4, 2q3, and 13q. Hybridization with a probe isolated from the UbB gene intron indicated that this gene is located within the region 17p11.1-17p12. This region showed the strongest hybridization with the coding-region probe and is presumably also the location of the duplicated UbB pseudogene.
Webb
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GC
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra.
Baker
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RT
Fagan
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Board
P G
PG
D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004247:DNA / Q000097:blood / Q000235:genetics; D015342:DNA Probes; D005796:Genes; D006801:Humans; D007438:Introns; D008297:Male; D009693:Nucleic Acid Hybridization; D011544:Pseudogenes; D014452:Ubiquitins / Q000235:genetics*
D015342:DNA Probes; D014452:Ubiquitins; D004247:DNA