[Cellular beta-adrenergic receptor complex in patients with heart failure and its changes during digoxin therapy].
Twenty eight males with dilated cardiomyopathy, 5 males with coronary heart disease concurrent with postinfarction cardiosclerosis, 4 males and 2 females with rheumatic heart disease were examined. The findings suggest desensitization of the cellular beta-adrenoreceptor complex in patients with circulatory failure, which appeared as lower beta-adrenoreceptor density with cardiac decompensation progression and impaired transmission of a hormonal signal in the cell, particularly in patients with dilated cardiomyopathy. Digoxin therapy let to an increase in beta-adrenoreceptor density with its initial decrease and to adenylate cyclase activity enhancement. The absence of a positive ++clinico-hemodynamic effect and time course of plasma catecholamine levels in some patients with severe circulatory failure during digoxin use, as well as no changes in the values of the beta-adrenoreceptor adenylate cyclase complex indicate that the abnormalities in beta-adrenergic regulation play an important role in the pathogenesis of refractoriness at the cellular level. Retention of forskolin's stimulant effect allows one to expect a significant positive therapeutic response to be shown with the usage of drugs whose load point is a catalytic subunit of adenylate cyclase.
Gabrusenko
S A
SA
Naumov
V G
VG
Krasnikova
T L
TL
Kupriianenko
T I
TI
Gadzhiev
A B
AB
Mazaev
A V
AV
Mukharliamov
N M
NM
D000262:Adenylyl Cyclases / Q000097:blood; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000503:physiopathology*; D004077:Digoxin / Q000627:therapeutic use*; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D004077:Digoxin; D000262:Adenylyl Cyclases; D009638:Norepinephrine; D004837:Epinephrine
Beta-adrenoretseptornyĭ kompleks kletok u bol'nykh s serdechnoĭ nedostatochnost'iu i ego izmeneniia pri terapii digoksinom.