Extraction of [18F]fluoride from [18O]water by a fast fibrous anion exchange resin.
[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [18O]H2O to avoid isotopic dilution of the target water.
Jewett
D M
DM
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0552.
Toorongian
S A
SA
Bachelor
M A
MA
Kilbourn
M R
MR
D000837:Anion Exchange Resins; D005462:Fluorine Radioisotopes / Q000302:isolation & purification*; D010103:Oxygen Isotopes; D014867:Water / Q000032:analysis*
D000837:Anion Exchange Resins; D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D014867:Water