Penicillic acid as Na+,K+ and Ca2+ channel blocker in isolated frog's heart at toxic levels.
The effect of penicillic acid on isolated frog's heart has been studied along with ions of Na+,K+ and Ca2+. Penicillic acid has been found to inhibit the entry of these ions into cardiac tissue thereby arresting the action of the heart. The blockage can be washed away by perfusion with Ringer's solution.
Pandiyan
V
V
Veterinary College and Research Institute, Namakkal, India.
Nayeem
M
M
Nanjappan
K
K
Ramamurti
R
R
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects*; D002208:Caproates / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D010398:Penicillic Acid / Q000633:toxicity*; D015221:Potassium Channels / Q000187:drug effects*; D011898:Ranidae; D015222:Sodium Channels / Q000187:drug effects*
D015220:Calcium Channels; D002208:Caproates; D015221:Potassium Channels; D015222:Sodium Channels; D010398:Penicillic Acid