title: A role for cyclic GMP in the initiation of cardiac pressor reflexes by bradykinin and capsaicin.
abstract: Reflexogenic effects of bradykinin on the cardiac sympathetic afferents supplying the dog epicardium were inhibited by treatment of the heart surface with either methylene blue or the compound LY-83583 (6-anilino-5,8-quinolinedione), which are known to lower cellular levels of cyclic GMP. Stimulation of cyclic GMP production by epicardial treatment with the NO-containing synonimine compound, SIN-1, potentiated bradykinin-induced reflex effects. In contrast, the sympathetic cardiac pressor response induced by capsaicin was not influenced by epicardial treatment with either methylene blue, LY-83583 or SIN-1. These findings indicate the importance of cyclic GMP for the reflexogenic activity of bradykinin, but not that of capsaicin on the sympathetic afferents supplying the dog heart.
authors.affiliation: Department of Physiology, Monash University, Clayton, Vic., Australia.
authors.forename: G
authors.initials: G
authors.lastname: Woolley
authors.forename: J
authors.initials: J
authors.lastname: Staszewska-Woolley
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology*; D006152:Cyclic GMP / Q000502:physiology*; D006321:Heart / Q000187:drug effects* / Q000294:innervation; D006801:Humans; D012018:Reflex / Q000502:physiology*
chemical_list: D006152:Cyclic GMP; D002211:Capsaicin; D001920:Bradykinin