Toxicity modification of sodium selenite by a brief exposure to heat or cold in mice.
The effect of a brief exposure to heat/cold on the subsequent development of toxicity of sodium selenite (SS) was evaluated in male ICR mice. Mice were exposed to one of three ambient temperatures (Ta; approx. 8 degrees, 22 degrees and 33 degrees C). One and a half hours after the beginning of the exposure, they were injected with 45 mumol/kg of SS subcutaneously. The exposure was terminated 3 h after injection and the mice were returned to Ta of 22 degrees C. Heat-induced enhancement of toxicity was recognized in some plasma enzyme activities 3 days after injection and in the suppression of body weight for up to 3 weeks. On the other hand, cold exposure alleviated SS toxicity in terms of these indices. Thus, the Ta during this short period was recognized to be important in determining subsequent development of SS toxicity. At the end of the thermal exposure, heat increased renal concentration of the injected Se. On the other hand, in the liver and the other organs examined, the highest Se concentration was found in the cold-exposed group, followed by the control (room temperature) and the heat-exposed. The relation between the modification of toxicity and the altered distribution was not clear. Neither glutathione level in the liver nor that in the kidney at the time of SS injection could explain the observed modification of the toxicity.
Watanabe
C
C
Department of Environmental Health Sciences, Tohoku University School of Medicine, Sendai, Japan.
Suzuki
T
T
Matsuo
N
N
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D003080:Cold Temperature; D003402:Creatine Kinase / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D006358:Hot Temperature; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012643:Selenium / Q000493:pharmacokinetics / Q000633:toxicity*; D018038:Sodium Selenite; D013696:Temperature; D014018:Tissue Distribution
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D005978:Glutathione; D012643:Selenium; D018038:Sodium Selenite