Wegener's granulomatosis: a review of 5 cases.
Wegener granulomatosis is a systemic disease with a wide spectrum of clinical manifestations. This is illustrated by 5 case reports. The diagnostic value of clinical, radiological, histological and serological signs are discussed and compared with the literature. Diagnosis has been facilitated by the introduction of serological tests: (anti-cytoplasmic antibody (ACPA) titer). High remission rates can be obtained with combined cyclophosphamide and prednisolone treatment. In case of a rapidly progressive glomerulonephritis, plasmapheresis presents a possible therapeutic advantage.
Veys
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N
Department of Internal Medicine, U.Z. Gent.
Offner
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F
Lameire
N
N
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003520:Cyclophosphamide / Q000008:administration & dosage; D003593:Cytoplasm / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007158:Immunologic Techniques; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011239:Prednisolone / Q000008:administration & dosage
D001323:Autoantibodies; D003520:Cyclophosphamide; D011239:Prednisolone