Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis.
To define a potential role for the angiotensin system in Crohn's colitis, the colonic mucosal levels of angiotensin I and II were measured in endoscopic biopsy samples from patients with active Crohn's colitis (n = 20), ulcerative colitis (n = 13), other forms of colitis (n = 3), and normal controls (n = 17). Colonic mucosal levels of angiotensin I and II were greater in patients with Crohn's colitis than in normal subjects (p less than 0.001 and p less than 0.001, respectively). Mucosal levels of angiotensin I and II were also higher in Crohn's colitis than in ulcerative colitis (p less than 0.001 and p less than 0.001, respectively), and levels of angiotensin II were higher in Crohn's than in other forms of colitis (p = 0.014). Mucosal levels of angiotensin I and II correlated well with the degree of macroscopic inflammation in Crohn's colitis (r = 0.86, p less than 0.001 and r = 0.68, p less than 0.001, respectively). Mucosal levels of angiotensin I correlated fairly well with the Crohn's Disease Activity Index (r = 0.46, p less than 0.05) while angiotensin II levels correlated poorly. These studies suggest that angiotensin I and II may have a role in the inflammation associated with Crohn's colitis.
Jaszewski
R
R
Division of Gastroenterology, Veterans Administration Medical Center, Allen Park, Michigan.
Tolia
V
V
Ehrinpreis
M N
MN
Bodzin
J H
JH
Peleman
R R
RR
Korlipara
R
R
Weinstock
J V
JV
D000803:Angiotensin I / Q000032:analysis* / Q000097:blood; D000804:Angiotensin II / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003092:Colitis / Q000378:metabolism / Q000473:pathology; D003093:Colitis, Ulcerative / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000032:analysis*; D003113:Colonoscopy; D003424:Crohn Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012812:Sigmoidoscopy; D016037:Single-Blind Method
D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A