[The short-term and long-term effects of gamma-irradiation on the inotropic reaction of the myocardium during the activation of alpha- and beta-adrenoreceptors].
The contractile function of myocardium was impaired and its inotropic response to stimulation of alpha- and beta-adrenoreceptors decreased at early times (1-30 days) following whole-body gamma-irradiation with a dose of 1.0 Gy. Six months after irradiation the response of the isolated myocardium to stimulation of adrenoreceptors increased to exceed that of intact animals. In a year the reactivity of the myocardium towards alpha-adrenoreceptor agonists remained high and its sensitivity of phenylephrine hydrochloride increased considerably; the response to beta-adrenoreceptor agonists was virtually absent.
Sineleva
M V
MV
Lobanok
L M
LM
D000818:Animals; D003037:Cobalt Radioisotopes; D005260:Female; D005720:Gamma Rays; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000502:physiology*; D010656:Phenylephrine / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical; D013997:Time Factors; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D010656:Phenylephrine; D007545:Isoproterenol
Blizhaĭshie i otdalennye éffekty gamma-oblucheniia na inotropnuiu reaktsiiu miokarda pri aktivatsii al'fa- i beta-adrenoretseptorov.