title: [Relations between Sheehan's syndrome and empty sella turcica. A functional study apropos of 6 cases].
abstract: We evaluated six patients in whom a diagnosis of Sheehan's syndrome had been made. The plasma levels of the following hormones were measured: basal thyroxine (T4), estradiol and cortisol; and also follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), thyrotropin (TSH), prolactin (PRL) and adrenocorticotropic hormone (ACTH), basally and after acute challenge with LH releasing hormone (LHRH), GRF (1-29)NH2 or insulin hypoglycemia, TSH releasing hormone (TRH) and lysine-8-vasopressin, respectively. Two patients underwent chronic LHRH stimulation by pulsatile subcutaneous administration with infusion pump. In 4 cases, computed tomography (CT) was performed although cranial X-ray study was normal. A severe and generalized pituitary involvement was found in all patients, 3 of whom had diabetes mellitus. Probably, more insidious cases go unnoticed. The presence of asymptomatic partial empty sella (ES) in all the CTs that were carried out raises the possibility that it is another evolutive feature of SS.
authors.affiliation: Servicio de Endocrinología, Hospital General Gregorio Marañón, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: López de la Torre Casares
authors.forename: M
authors.initials: M
authors.lastname: Gargallo Fernández
authors.forename: B
authors.initials: B
authors.lastname: Moreno Esteban
authors.forename: M D
authors.initials: MD
authors.lastname: Rodríguez Arnao
authors.forename: A
authors.initials: A
authors.lastname: Jara Albarrán
authors.forename: P
authors.initials: P
authors.lastname: Rodríguez Poyo-Guerrero
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D004652:Empty Sella Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D013963:Thyroid Hormones; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone
vernacular_title: Relación entre síndrome de Sheehan y silla turca vacía. Estudio funcional a propósito de 6 casos.