title: Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.
abstract: The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus.
authors.affiliation: Département de Biochimie des Glycoconjugués et Lectines Endogènes, CNRS, INSERM, Orléans, France.
authors.forename: P
authors.initials: P
authors.lastname: Midoux
authors.forename: E
authors.initials: E
authors.lastname: Negre
authors.forename: A C
authors.initials: AC
authors.lastname: Roche
authors.forename: R
authors.initials: R
authors.lastname: Mayer
authors.forename: M
authors.initials: M
authors.lastname: Monsigny
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: E
authors.initials: E
authors.lastname: Mayer
authors.forename: A
authors.initials: A
authors.lastname: Ghaffar
authors.forename: J D
authors.initials: JD
authors.lastname: Gangemi
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D007202:Indicators and Reagents; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D015394:Molecular Structure; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D063065:Organophosphonates; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D063065:Organophosphonates; D011108:Polymers; C053001:adefovir; D000225:Adenine