N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.
The effects of two high-affinity sigma ligands, DTG (1,3-di(2-tolyl)guanidine) and haloperidol, on the activation of dorsal hippocampus pyramidal neurons induced by microiontophoretic application of N-methyl-D-aspartate (NMDA) were assessed electrophysiologically. Low doses of DTG (0.5-3 micrograms/kg i.v.) potentiated the NMDA response. This effect of DTG was blocked by haloperidol (10 micrograms/kg i.v.), but not by spiperone, a potent dopamine antagonist with low affinity for sigma receptors. These results suggest that sigma receptors modulate the NMDA-induced neuronal activation.
Monnet
F P
FP
Department of Psychiatry, McGill University, Montréal, Québec, Canada.
Debonnel
G
G
Junien
J L
JL
De Montigny
C
C
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D007478:Iontophoresis; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects*; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D017480:Receptors, sigma; D013134:Spiperone / Q000494:pharmacology
D006146:Guanidines; D010069:Oxadiazoles; D011957:Receptors, Opioid; D017480:Receptors, sigma; D001224:Aspartic Acid; D013134:Spiperone; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D006220:Haloperidol; C050232:1,3-ditolylguanidine; D007608:Kainic Acid