title: Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats.
abstract: The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.
authors.affiliation: Department of Anatomy, University of Mainz, Federal Republic of Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Koch
authors.forename: H K
authors.initials: HK
authors.lastname: Biesalski
authors.forename: E
authors.initials: E
authors.lastname: Stofft
authors.forename: H
authors.initials: H
authors.lastname: Weiser
authors.forename: H E
authors.initials: HE
authors.lastname: Gabbert
authors.forename: H P
authors.initials: HP
authors.lastname: Dienes
authors.forename: B
authors.initials: B
authors.lastname: Schulz-Dobrick
authors.forename: K H
authors.initials: KH
authors.lastname: Bässler
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007583:Jejunum / Q000378:metabolism / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014802:Vitamin A Deficiency / Q000473:pathology*