The non-tyrosinated M alpha 4 alpha-tubulin gene product is post-translationally tyrosinated in adult rat cerebellum.
The distributions of the non-tyrosinated M alpha 4 alpha-tubulin gene product and its tyrosinated form M alpha 4 + Y were examined in immunoblots and sections of adult rat brain. In cerebellar sections, M alpha 4 and M alpha 4 + Y immunoreactivities were enriched in neurons, anti-M alpha 4 + Y labeling thus being more restricted in distribution than that of the general alpha-tubulin antibody YL1/2. The results indicate that the M alpha 4 gene product does not constitute the large non-tyrosinatable pool of alpha-tubulin in brain.
Cambray-Deakin
M A
MA
Physiological Laboratory, University of Liverpool, U.K.
Burgoyne
R D
RD
D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D051381:Rats; D014404:Tubulin / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D014404:Tubulin; D014443:Tyrosine