Long-term hypotensive effect of parathyroid hormone in stroke prone spontaneously hypertensive rats.
The influence of long-term treatment with parathyroid hormone (PTH) on blood pressure (BP) development in stroke prone spontaneously hypertensive rats (SHR/SP) was investigated. Acute i.v. administration of PTH decreased BP dose dependently. Long-term treatment of SHR/SP with 300 IU PTH s.c. per day clearly attenuated the BP increase. Treatment with PTH was associated with marked hypercalcemia, increased urinary excretion of calcium and cAMP.
Neuser
D
D
Bayer AG, Department of Pharmacology, Pharma Research Center, Wuppertal 1, F.R.G.
Schulte-Brinkmann
R
R
Knorr
A
A
Kazda
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D000242:Cyclic AMP / Q000652:urine; D006961:Hyperparathyroidism / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002118:Calcium