title: Amniotic membranes in the treatment of necrotizing fasciitis complicating vulvar herpes virus infection.
abstract: Necrotizing fasciitis of the vulva developed in an immunocompromised patient with chronic myelogenous leukemia, apparently from secondarily infected herpes simplex lesions. In addition to surgical debridements and broad-spectrum intravenous antibiotic therapy, the wound was treated using specially prepared amniotic membranes as a wound dressing. The patient died on hospital day 65 because of complications of her immunocompromised state, with autopsy findings of disseminated cytomegalovirus. However, use of amniotic membranes as a wound dressing appeared to be beneficial.
authors.affiliation: Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: P A
authors.initials: PA
authors.lastname: Rothman
authors.forename: A K
authors.initials: AK
authors.lastname: Wiskind
authors.forename: A G
authors.initials: AG
authors.lastname: Dudley
mesh_terms: D000328:Adult; D000650:Amnion; D001458:Bandages; D001684:Biological Dressings; D005208:Fasciitis / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D009336:Necrosis; D014847:Vulvitis / Q000150:complications / Q000209:etiology / Q000628:therapy*