Granule cell potentials in the dentate gyrus of the hippocampus: coping behavior and stress ulcers in rats.
Evoked population potentials of the granule cells in the dentate gyrus of the hippocampus were increased in stress-resistant rats and decreased in stress-susceptible rats, as indexed by restraint-induced gastric ulcers. Inescapable, uncontrollable shock stimulation also suppressed granule cell population spikes and interfered with subsequent coping responses when escape was possible, i.e. the so-called helplessness effect. The data were interpreted to indicate that the hippocampus is part of a coping system in stressful situations.
Henke
P G
PG
Department of Psychology, St. Francis Xavier University, Antigonish, N.S., Canada.
D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000502:physiology*; D004569:Electroencephalography; D004597:Electroshock; D004924:Escape Reaction / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D005239:Fear / Q000502:physiology; D006380:Helplessness, Learned; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications*; D009435:Synaptic Transmission / Q000502:physiology