title: Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report.
abstract: Data from Northern California Oncology Group protocol 6G61, which was closed in February 1983, were reanalyzed in December 1988. The protocol called for a randomized trial that compared the effects of following 60 Gy radiation/oral hydroxyurea treatment with either carmustine (BCNU) or the combination of procarbazine, lomustine (CCNU), and vincristine (PCV) for two histologic strata: glioblastoma multiforme and other anaplastic gliomas. PCV produced longer survival and time to tumor progression than BCNU for both histologic groups, although the difference was statistically significant only for the anaplastic gliomas. With PCV treatment, time to progression and survival doubled for anaplastic glioma patients in the 50th and 25th percentiles.
authors.affiliation: Department of Neurological Surgery, University of California-San Francisco Medical School 94143.
authors.forename: V A
authors.initials: VA
authors.lastname: Levin
authors.forename: P
authors.initials: P
authors.lastname: Silver
authors.forename: J
authors.initials: J
authors.lastname: Hannigan
authors.forename: W M
authors.initials: WM
authors.lastname: Wara
authors.forename: P H
authors.initials: PH
authors.lastname: Gutin
authors.forename: R L
authors.initials: RL
authors.lastname: Davis
authors.forename: C B
authors.initials: CB
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002330:Carmustine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000188:drug therapy / Q000532:radiotherapy; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011344:Procarbazine / Q000008:administration & dosage; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D014481:United States; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine; D002330:Carmustine