title: Itraconazole in the management of chronic dermatophytosis.
abstract: Fifty-five patients with griseofulvin-unresponsive dermatophytosis caused by Trichophyton rubrum were treated with itraconazole. They had either tinea corporis or "dry type" infections of the palms, soles, or nails. The following sites were affected: trunk (12 infections), soles (47), toe webs (52), palms (26), fingernails (29), and toenails (42). Patients were treated with oral itraconazole until clinical and mycologic remission were achieved. Response rates and mean times to recovery were as follows: trunk, 100%, 1.5 months; soles, 83%, 6.7 months; toe webs, 90%, 7.2 months; palms, 96%, 4.6 months; fingernails, 90%, 5.4 months; and toenails, 76%, 10.3 months). In a 6-month follow-up period 7 of 30 patients with toenail infections who had responded to treatment had a clinical and mycologic relapse, usually of one nail. Side effects were minimal but included abdominal discomfort (three patients), headache (one), and weight gain (two). No persistent abnormalities in blood biochemistry were seen, even in patients who received itraconazole for more than 9 months.
authors.affiliation: Mycology Department, St. John's Hospital for Diseases of the Skin, London, United Kingdom.
authors.forename: R J
authors.initials: RJ
authors.lastname: Hay
authors.forename: Y M
authors.initials: YM
authors.lastname: Clayton
authors.forename: M K
authors.initials: MK
authors.lastname: Moore
authors.forename: G
authors.initials: G
authors.lastname: Midgely
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D003881:Dermatomycoses / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005385:Fingers; D005533:Foot Dermatoses / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014034:Toes
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole