[Successful high-dose methylprednisolone therapy in a patient with primary myelofibrosis].
We are presenting a patient with primary myelofibrosis who responded to the High-Dose methylprednisolone therapy (1 g/day for 3 days). Three and a half years ago, a 55-year-old male was admitted to our hospital because of severe erythroblastic anemia, thrombocytopenia, splenomegaly and "dry tap" of bone marrow aspiration. Bone marrow biopsy revealed a marked fibrosis without any blastoid cell proliferations. Since a thrombocytopenia was progressive and refractory to the ordinary therapy, high-dose methylprednisolone therapy was performed which was followed by an administration of activated vitamin D3. After the therapy, hematologic improvements were achieved within a month (RBC: 284 x 10(4)/microliters----413 x 10(4)/microliters, WBC: 3,000/microliters----11,500/microliters, Plat.: 7,000/microliters----20,000/microliters). Three months after the therapy, the bone marrow biopsy and 113In scintigraphy were performed. These tests also proved marked improvement of histological features of the bone marrow and a decrease of uptake of 113In to the spleen, respectively. The patient continues to be in good condition and he is free from any medications at present time.
Matsukawa
Y
Y
First Department of Internal Medicine, Nihon University School of Medicine.
Ikeda
E
E
Suguro
H
H
Iizuka
Y
Y
Nishinarita
S
S
Hayama
T
T
Ohshima
T
T
Sawada
S
S
Horie
T
T
D001853:Bone Marrow / Q000000981:diagnostic imaging; D002762:Cholecalciferol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging
D002762:Cholecalciferol; D008775:Methylprednisolone