Tumor-associated trypsin inhibitor and cancer antigen 125 in pelvic masses.
Tumor-associated trypsin inhibitor (TATI) and cancer antigen 125 (CA-125) were measured pre- and peroperatively in 183 patients with a pelvic mass to elucidate the value of TATI alone and in combination with CA-125 as a differential diagnostic tool. Malignant tumors were registered in 109 patients (90 ovarian and 19 nonovarian cases), borderline ovarian tumors in 8, and benign tumors in 66 (50 ovarian and 16 nonovarian). The TATI level was increased only in half of the patients with malignant tumors; therefore, the marker cannot be used alone as a preoperative diagnostic tool. In contrast, CA-125 had a sensitivity of 82%, which rose to 91% when the marker was used in combination with TATI. CA-125 and TATI had a combined specificity of 76% and positive and negative predictive values of 87 and 83%, respectively. Our results indicate that TATI measurement substantially improves the preoperative differential diagnostic information obtained with CA-125 and that it does not significantly increase the number of false-positive findings. We recommend the complementary measurement of TATI in patients who have a pelvic mass and a normal CA-125 level.
Mogensen
O
O
Danish Cancer Society, Department of Immunoserology, Aarhus, Denmark.
Mogensen
B
B
Jakobsen
A
A
D000236:Adenoma / Q000175:diagnosis; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis; D003560:Cysts / Q000175:diagnosis; D003884:Dermoid Cyst / Q000175:diagnosis; D003937:Diagnosis, Differential; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis; D005260:Female; D005350:Fibroma / Q000175:diagnosis; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis; D006106:Granulosa Cell Tumor / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D011863:Radioimmunoassay; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000175:diagnosis; D009396:Wilms Tumor / Q000175:diagnosis
D015295:Antigens, Tumor-Associated, Carbohydrate; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic