title: [Successful high-dose methylprednisolone therapy in a patient with primary myelofibrosis].
abstract: We are presenting a patient with primary myelofibrosis who responded to the High-Dose methylprednisolone therapy (1 g/day for 3 days). Three and a half years ago, a 55-year-old male was admitted to our hospital because of severe erythroblastic anemia, thrombocytopenia, splenomegaly and "dry tap" of bone marrow aspiration. Bone marrow biopsy revealed a marked fibrosis without any blastoid cell proliferations. Since a thrombocytopenia was progressive and refractory to the ordinary therapy, high-dose methylprednisolone therapy was performed which was followed by an administration of activated vitamin D3. After the therapy, hematologic improvements were achieved within a month (RBC: 284 x 10(4)/microliters----413 x 10(4)/microliters, WBC: 3,000/microliters----11,500/microliters, Plat.: 7,000/microliters----20,000/microliters). Three months after the therapy, the bone marrow biopsy and 113In scintigraphy were performed. These tests also proved marked improvement of histological features of the bone marrow and a decrease of uptake of 113In to the spleen, respectively. The patient continues to be in good condition and he is free from any medications at present time.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsukawa
authors.forename: E
authors.initials: E
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Suguro
authors.forename: Y
authors.initials: Y
authors.lastname: Iizuka
authors.forename: S
authors.initials: S
authors.lastname: Nishinarita
authors.forename: T
authors.initials: T
authors.lastname: Hayama
authors.forename: T
authors.initials: T
authors.lastname: Ohshima
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Horie
mesh_terms: D001853:Bone Marrow / Q000000981:diagnostic imaging; D002762:Cholecalciferol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging
chemical_list: D002762:Cholecalciferol; D008775:Methylprednisolone