beta-CCM inhibits muricide induced by olfactory bulbectomy in rats.
Intravenous administration of beta-CCM (methyl-beta-carboline-3-carboxylate) at doses ranging from 0.3 to 10 mg/kg dose-dependently inhibited muricide in olfactory bulbectomized rats. beta-CCM elicited a decrease of locomotor activity at doses ranging from 0.3 to 3 mg/kg, and it impaired rotarod performance at doses of 1 and 3 mg/kg. The inhibition of muricide induced by beta-CCM was antagonized by intraperitoneal administration of Ro15-1788 at 10 mg/kg or diazepam at 3 mg/kg. However, the hypolocomotor activity and impairment of rotarod performance induced by beta-CCM were not antagonized by diazepam at 3 mg/kg. These results indicated that beta-CCM exerts an inhibitory effect on muricide through benzodiazepine receptors and this inhibitory effect was not solely caused by its sedative or motor incordinating activity at the dose ranges used in this study.
Nagatani
T
T
Department of Pharmacology, Asahi Chemical Ind. Co., Ltd., Miyazaki, Japan.
Yamamoto
T
T
Takao
K
K
Sugihara
T
T
Ueki
S
S
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002243:Carbolines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central; D009830:Olfactory Bulb / Q000502:physiology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects
D002243:Carbolines; D009125:Muscle Relaxants, Central; D011963:Receptors, GABA-A; D010643:Phenoxybenzamine; D005442:Flumazenil; C036150:beta-carboline-3-carboxylic acid methyl ester; D003975:Diazepam