title: Effect of toxic doses of cholecalciferol (vitamin D3) on alkaline phosphatase levels in serum and gingival tissues of rats.
abstract: Toxic doses of cholecalciferol (vitamin D3) were injected subcutaneously (25 micrograms/day) into rats for 5 weeks, causing a significant increase of serum alkaline phosphatase (ALP) levels (p less than 0.01). Gingival tissue alkaline phosphatase levels were also elevated (p less than 0.01). On the other hand, a significant difference was detected between serum calcium levels in experimental and control groups (p less than 0.02).
authors.affiliation: Department of Biochemistry, Faculty of Dentistry, University of Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Güven
authors.forename: C
authors.initials: C
authors.lastname: Kasapoğlu
authors.forename: S
authors.initials: S
authors.lastname: Yildirim
authors.forename: O
authors.initials: O
authors.lastname: Gümrü
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis / Q000097:blood*; D000818:Animals; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage / Q000633:toxicity*; D005881:Gingiva / Q000201:enzymology*; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002762:Cholecalciferol; D000469:Alkaline Phosphatase; D002118:Calcium