title: A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X.
abstract: There are at least three transcriptionally active human ADP/ATP translocase genes. We have isolated seven ADP/ATP translocase pseudogenes from recombinant human genomic libraries. Each pseudogene sequence had more than 85% identity with the sequence of the human ADP/ATP translocase cDNA derived from fibroblast mRNA, but each had mutations that precluded synthesis of a functional protein. Using an intron probe derived from a partial clone of the human fibroblast ADP/ATP translocase gene, we localized the gene to chromosome Xq13----Xq25-26. The gene encoding the skeletal muscle translocase has previously been shown to be on chromosome 4. Therefore, the human ADP/ATP translocase genes are members of a multigene family that includes pseudogenes and has been dispersed to at least two chromosomes.
authors.affiliation: Department of Pathology, Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania.
authors.forename: S T
authors.initials: ST
authors.lastname: Chen
authors.forename: C D
authors.initials: CD
authors.lastname: Chang
authors.forename: K
authors.initials: K
authors.lastname: Huebner
authors.forename: D H
authors.initials: DH
authors.lastname: Ku
authors.forename: M
authors.initials: M
authors.lastname: McFarland
authors.forename: J K
authors.initials: JK
authors.lastname: DeRiel
authors.forename: R
authors.initials: R
authors.lastname: Baserga
authors.forename: J
authors.initials: J
authors.lastname: Wurzel
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000032:analysis / Q000648:ultrastructure*; D004247:DNA / Q000032:analysis / Q000235:genetics; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology / Q000201:enzymology; D007438:Introns; D000226:Mitochondrial ADP, ATP Translocases / Q000235:genetics*; D008969:Molecular Sequence Data; D009713:Nucleotidyltransferases / Q000235:genetics*; D011544:Pseudogenes; D015183:Restriction Mapping; D014158:Transcription, Genetic
chemical_list: D004247:DNA; D000226:Mitochondrial ADP, ATP Translocases; D009713:Nucleotidyltransferases