title: Oral treatment with itraconazole of aspergilloma in cavitary lung cancer.
abstract: We report a case of aspergilloma in a necrotic small cell lung cancer, where poor pulmonary function and performance status of the patient precluded surgical treatment. High dose Itraconazole, a new oral anti-mycotic drug, was given for 13 months. During this treatment there was a decrease of the fungus ball size and no haemoptysis. Moreover control of the aspergilloma allowed chemotherapeutic treatment of the underlying bronchocarcinoma.
authors.affiliation: Dept of pneumology, A.Z. VUB, Vrije Universiteit, Brussel, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Impens
authors.forename: J
authors.initials: J
authors.lastname: De Greve
authors.forename: K
authors.initials: K
authors.lastname: De Beule
authors.forename: M
authors.initials: M
authors.lastname: Meysman
authors.forename: S
authors.initials: S
authors.lastname: De Beuckelaere
authors.forename: W
authors.initials: W
authors.lastname: Schandevyl
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D018288:Carcinoma, Small Cell / Q000150:complications*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole