title: Viral etiology of chronic cervicitis and its therapeutic response to a recombinant interferon.
abstract: Chronic cervicitis was shown to be related to papillomavirus type 16(HPV-16), herpes simplex virus type 2 and cytomegalovirus (CMV) infections as demonstrated by DNA hybridization technique and virus isolation method from samples taken from erosive and normal cervices. After one course of treatment with recombinant interferon alpha 1 (rIFN-alpha 1), 93.8% of cases showed clinical improvement and 60% marked improvement. The HPV-16 and HSV detection rates dropped down significantly after rIFN-alpha 1 treatment as compared with those before treatment. Astragalus membranaceus, a Chinese herbal drug, was shown to be synergic to interferon therapy.
authors.affiliation: Beijing Tian Tan Hospital.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Qian
authors.forename: S J
authors.initials: SJ
authors.lastname: Mao
authors.forename: X C
authors.initials: XC
authors.lastname: Cai
authors.forename: X L
authors.initials: XL
authors.lastname: Zhang
authors.forename: F X
authors.initials: FX
authors.lastname: Gao
authors.forename: M F
authors.initials: MF
authors.lastname: Lu
authors.forename: X S
authors.initials: XS
authors.lastname: Shao
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.forename: X K
authors.initials: XK
authors.lastname: Yang
authors.forename: Y A
authors.initials: YA
authors.lastname: Zhuo
mesh_terms: D000328:Adult; D027885:Astragalus propinquus; D003131:Combined Modality Therapy; D003587:Cytomegalovirus / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D011994:Recombinant Proteins; D018139:Simplexvirus / Q000302:isolation & purification; D002575:Uterine Cervicitis / Q000382:microbiology* / Q000628:therapy
chemical_list: D004365:Drugs, Chinese Herbal; D007370:Interferon Type I; D011994:Recombinant Proteins