[The leukotriene B4 content of the bronchoalveolar lavage fluid and the function of the prostacyclin-thromboxane system in patients with variants of chronic bronchitis].
A study was made of the content of leukotriene B4, prostacycline and thromboxane A2 in the fluid of bronchoalveolar lavage in 62 patients with chronic bronchitis (CB) in the stage of exacerbation and remission. The time course of changes in the concentration of the eukosanoids was compared with the status of pulmonary local defense factors and cellular immunity. In catarrhal obstructive bronchitis, an important mechanism of a steady maintenance of bronchial obstruction involved a rise of the content of leukotriene B4 whereas in purulent obstructive bronchitis, it was an excess level of thromboxane A2. It is assumed that immunologically dependent activation of the leukotriene B4 and thromboxane synthetase capacity of alveolar macrophages may stipulate the clinical course of CB, modulating the bronchoconstrictor or inflammatory component of the disease. To correct phlogogenous function of alveolar macrophages, the use of immunomodulating therapy with a selective action on the suppressor component of immunity is desirable.
Efimov
V V
VV
Blazhko
V I
VI
Voeĭkova
L S
LS
Karamysheva
S A
SA
Bondar'
T N
TN
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000328:Adult; D001991:Bronchitis / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis* / Q000276:immunology; D001999:Bronchoscopy; D002908:Chronic Disease; D011464:Epoprostenol / Q000032:analysis*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007975:Leukotriene B4 / Q000032:analysis*; D008875:Middle Aged; D013928:Thromboxane A2 / Q000032:analysis*; D013929:Thromboxane B2 / Q000032:analysis
D007975:Leukotriene B4; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol
Soderzhanie leĭkotriena B4 v zhidkosti bronkhoal'veoliarnogo lavazha i sostoianie prostatsiklintromboksanovoĭ sistemy u bol'nykh s razlichnymi variantami khronicheskogo bronkhita.