[The effect of angiotensin II on the catecholamine content of the blood plasma in rats].
I. v. administration of angiotensin II (0.1, 0.3 and 1.0 microgram/kg/min for 5 min) raised the plasma norepinephrine level in the right atrium and carotid artery in a reverse dose-dependent manner. The veno-arterial difference decreased dose-dependently to 17.4, 7.2 and 0.1 per cent, resp., versus 21.8 per cent in the control group. The plasma norepinephrine level was decreased and the veno-arterial difference was similar to basal level at 1.0 microgram/kg/min dose of angiotensin II for 40 min. Angiotensin II seems to affect the lung uptake and inactivation of norepinephrine in phasic manner.
Bonetskiĭ
A A
AA
Fedorov
V I
VI
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001158:Arteries; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014680:Veins
D002395:Catecholamines; D000804:Angiotensin II
Vliianie angiotenzina II na soderzhanie katekholaminov v plazme krovi u krys.