[Effects of serotonin on antigen-nonspecific suppressors of the thymus].
Study of nonspecific suppressors of the thymus in inhibition of immune response by serotonin is carried out in CBA mice. We have tested a selective effect of 2-deoxyguanosine on antigen nonspecific T suppressors of the thymus. In syngeneic adoptive transfer on the 3rd day after immunization it is established that antigen nonspecific immune response (rosette-forming cells) after serotonin treatment amounts to 71%, in intact animals--37%. When estimating the plague forming cells the antigen nonspecific suppressive thymocytes make up 21.9% in immune mice, 62.5% in immune mice after serotonin treatment, 29.7% in intact animals.
Morozova
N B
NB
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D003849:Deoxyguanosine / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D004854:Herpesvirus 4, Human / Q000276:immunology; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D012701:Serotonin / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D000956:Antigens, Viral; D012701:Serotonin; D003849:Deoxyguanosine
Vliianie serotonina na antigennespetsificheskie supressory timusa.