Predictors of local recurrence following conservative breast surgery and radiation therapy. The influence of tumor size.
Size of tumor has not been established as a predictor of tumor recurrence in the breast following conservative surgery and radiation therapy. We analyzed 783 patients with infiltrating carcinoma treated with simple excision and radiation therapy. Median follow-up was 91 months. Median age at diagnosis was 50 years. There was a 13% recurrence among patients with T1 lesions compared with a 12% recurrence among patients with T2 tumors. Size did not predict for local recurrence when the tumor was analyzed by 1-cm increments and whether the tumor was estrogen receptor protein positive or estrogen receptor protein negative. Patients with an extensive intraductal component had a significantly higher local recurrence rate for every tumor size compared with patients with extensive intraductal component-negative tumors. We concluded that size did not predict local recurrence.
Eberlein
T J
TJ
Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115.
Connolly
J L
JL
Schnitt
S J
SJ
Recht
A
A
Osteen
R T
RT
Harris
J R
JR
D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008408:Mastectomy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D011878:Radiotherapy; D011960:Receptors, Estrogen / Q000032:analysis
D011960:Receptors, Estrogen