title: Cytomegalovirus infection in women attending a sexually transmitted disease clinic.
abstract: To evaluate prospectively the relationship between current and past sexual practices and seroprevalence of cytomegalovirus (CMV) in adult women, 1481 women (1101 white, 301 black, 79 other) attending a sexually transmitted disease clinic underwent a standardized interview and genital examination. CMV seroprevalence was higher in black (78%) than in white (59%) women. In logistic regression models that adjusted for age and years of education, CMV seropositivity in white women was associated with younger sexual debut (P = .001), more lifetime sex partners (P = .025), recent new partner(s) (P = .003), and parity (P = .002), and was inversely associated with use of barrier contraception (P = .006). In black women, after adjustment for demographic characteristics, CMV antibody was associated with greater numbers of recent sex partners (P = .007), new sex partners (P = .04), and with cervical infection with Chlamydia trachomatis (P = .05). This study confirms that sexual activity is an important determinant of CMV infection in both white and black women; however, the relative contributions of sexual and nonsexual transmission of CMV apparently vary and require further investigation.
authors.affiliation: Department of Medicine and Laboratory Medicine, School of Medicine, University of Washington, Seattle.
authors.forename: A C
authors.initials: AC
authors.lastname: Collier
authors.forename: H H
authors.initials: HH
authors.lastname: Handsfield
authors.forename: P L
authors.initials: PL
authors.lastname: Roberts
authors.forename: T
authors.initials: T
authors.lastname: DeRouen
authors.forename: J D
authors.initials: JD
authors.lastname: Meyers
authors.forename: L
authors.initials: L
authors.lastname: Leach
authors.forename: V L
authors.initials: VL
authors.lastname: Murphy
authors.forename: M
authors.initials: M
authors.lastname: Verdon
authors.forename: L
authors.initials: L
authors.lastname: Corey
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000914:Antibodies, Viral / Q000032:analysis*; D015331:Cohort Studies; D003267:Contraception; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology*; D004522:Educational Status; D005260:Female; D006801:Humans; D015995:Prevalence; D011446:Prospective Studies; D012044:Regression Analysis; D012725:Sexual Behavior; D012747:Sexual Partners; D012749:Sexually Transmitted Diseases / Q000453:epidemiology*; D044465:White People
chemical_list: D000914:Antibodies, Viral