Decreased beta-adrenergic responses of rat small intestine due to non-insulin-dependent diabetes.
Relaxing responses to salbutamol of duodenum, jejunum and ileum isolated from alloxan-induced non-insulin-dependent diabetic rats were investigated by means of pharmacodynamic analysis using pD2 (apparent receptor affinity) and alpha E (intrinsic activity) values. beta-Adrenergic responses of these three intestinal parts of diabetic rats were found to be significantly decreased when compared to controls. The decreased responses may be attributable to a decrease in the number of beta-adrenergic receptors. The gastro-intestinal manifestations reported in diabetic patients are possibly linked to the occurrence of a decrease in beta-adrenergic receptors. Furthermore, this model seems to be useful for the investigations of gastro-intestinal complications resulting from non-insulin-dependent diabetes.
Oztürk
Y
Y
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Yildizoğlu-Ari
N
N
Ozüari
A
A
Ozçelikay
A T
AT
Altan
V M
VM
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004386:Duodenum / Q000503:physiopathology; D007082:Ileum / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D007583:Jejunum / Q000503:physiopathology; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin; D011943:Receptors, Adrenergic, beta; D000420:Albuterol