Role of neutrophils in the intestinal alterations associated with thermal injury.
We have examined the role of neutrophils in the alterations observed in the intestines of rats subjected to 40 per cent surface area scald injury. Histologically, there was no evidence of neutrophilia in the intestinal tissue, and myeloperoxidase activity in mucosal scrapings was not elevated. The distribution of labelled human neutrophils injected into the burned rats showed no enhancement of uptake in the intestines, although there was increased uptake by the lung. The present data suggest that neutrophil migration may not play a role in the alterations in small intestinal function and morphology seen in burn trauma in the rat, but may be a factor in lung damage associated with thermal injury.
Trop
M
M
Department of Pediatrics, Shriners Burns Institute, Boston, Massachusetts.
Schiffrin
E J
EJ
Carter
E A
EA
D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000473:pathology; D002056:Burns / Q000503:physiopathology*; D002465:Cell Movement; D005260:Female; D007421:Intestine, Small / Q000473:pathology / Q000503:physiopathology*; D009336:Necrosis; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats
D009195:Peroxidase