Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11.
Monoclonal antibodies recognizing human papillomavirus type 11 (HPV-11) were prepared from BALB/c mice immunized with intact HPV-11 virions obtained from morphologically transformed human foreskin xenografts grown subrenally in athymic mice. Four of five monoclonal antibodies that were reactive by enzyme-linked immunosorbent assay only to intact virions neutralized HPV-11 infectivity in the athymic mouse xenograft system.
Christensen
N D
ND
Department of Pathology, Milton S. Hershey Medical Center, Pennsylvania 17033.
Kreider
J W
JW
Cladel
N M
NM
Patrick
S D
SD
Welsh
P A
PA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D003218:Condylomata Acuminata / Q000276:immunology / Q000382:microbiology; D015344:DNA Probes, HPV; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008819:Mice, Nude; D009500:Neutralization Tests; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000276:immunology*; D016038:Skin Transplantation; D014764:Viral Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D015344:DNA Probes, HPV; D014764:Viral Proteins