Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation.
In a light/dark choice procedure, the imidazothienodiazepinone RO 19-4603, given alone, induced a dose-dependent decrease in the time spent by mice in the lit box as well in the number of transitions between the two boxes. These data confirm the anxiogenic intrinsic properties of inverse agonists of the benzodiazepine receptor. Since RO 19-4603 also reversed the anxiolytic effects of ethanol and exhibited proconvulsant properties, it is suggested that the antagonistic action of this drug against ethanol could be due to an additive rather than an interactive process.
Belzung
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Laboratoire de Psychophysiologie, Strasbourg, France.
Misslin
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R
Vogel
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E
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced
D001381:Azepines; D011963:Receptors, GABA-A; D000431:Ethanol; C056530:Ro 19-4603; D010433:Pentylenetetrazole