title: The significance of the detection of cytomegalovirus in the bronchoalveolar lavage fluid in AIDS patients with pneumonia.
abstract: We performed a retrospective study on 112 patients with AIDS-related pneumonias who underwent bronchoscopy and in whom Pneumocystis carinii pneumonia (PCP) and/or cytomegalovirus (CMV) were identified in bronchoalveolar fluid (BAL). CMV was identified by detection of early antigen fluorescent foci (DEAFF) testing in cell cultures of BAL fluid. The short- and long-term survival of all patients was similar regardless of whether PCP, CMV or both were detected at bronchoscopy. Ten out of 14 patients with CMV alone and 13 out of 26 with both CMV and PCP were treated with anti-CMV therapy, but the short- and long-term mortality was similar to that in patients who had no specific antiviral therapy. Extrapulmonary recurrence of CMV (retinitis or gastrointestinal disease) occurred in 22% of patients with evidence of CMV in BAL compared with 16% of those with PCP alone, but this difference was not statistically significant and this recurrence rate was independent of anti-CMV therapy. Detection of CMV shedding from more than one site (BAL, urine, throat or blood) was associated with a worse prognosis at 3 months than in patients in whom CMV was detected in BAL alone. It does not appear that finding CMV shedding is a guide to the cause of pneumonia or an indication for treatment in AIDS patients.
authors.affiliation: AIDS Unit, Westminster Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Bower
authors.forename: S E
authors.initials: SE
authors.lastname: Barton
authors.forename: M R
authors.initials: MR
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Bobby
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Youle
authors.forename: B G
authors.initials: BG
authors.lastname: Gazzard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D000914:Antibodies, Viral / Q000032:analysis*; D000998:Antiviral Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D001999:Bronchoscopy; D003092:Colitis / Q000150:complications; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D004941:Esophagitis / Q000150:complications; D005455:Fluorescent Antibody Technique; D006801:Humans; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D012008:Recurrence; D012173:Retinitis / Q000150:complications; D012189:Retrospective Studies
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents