Glucagon-like peptide-1(7-37) does not stimulate either hepatic glycogenolysis or ketogenesis.
Recent Studies have demonstrated that glucagon-like peptide-1 (GLP)(7-37) has more potent insulinotropic activity than glucagon. We therefore examined the effect of GLP-1(7-37) on liver metabolism using rat liver perfusion system. Ten nM GLP-1(7-37) did not affect glucose, ketone body and cAMP outputs from the perfused liver. Whereas, the same dose of glucagon stimulated these outputs significantly. When 10 nM GLP-1(7-37) perfused 5 min before the administration of 10 nM glucagon, the above stimulatory effects of glucagon were not affected. These results indicate that truncated GLP-1 has no effect on hepatic glycogenolysis and ketogenesis dissociating from its potent insulinotropic activity.
Murayama
Y
Y
Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Kawai
K
K
Suzuki
S
S
Ohashi
S
S
Yamashita
K
K
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D007659:Ketones / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007659:Ketones; D010446:Peptide Fragments; D010455:Peptides; C061970:glucagon-like peptide 1 (7-36); D004763:Glucagon-Like Peptides; C055968:glucagon-like peptide 1 (1-37); D052216:Glucagon-Like Peptide 1; D006003:Glycogen; D005934:Glucagon; D000242:Cyclic AMP; D005947:Glucose