Growth regulation by insulin-like growth factors in lung cancer.
Lung cancer is a major health problem, with over 38,000 new cases expected every year in West Germany. A more complete understanding of the biology of lung cancer will hopefully lead to therapeutic modalities. The possible autocrine growth regulation in small-cell lung cancer and non-small-cell lung cancer has been demonstrated for bombesin/GRP, vasopressin, neurotensin, EGF/TGF alpha, transferrin-related peptides and insulin-like growth factors. This contribution concentrates on recent data concerning binding sites, growth promoting effects and secretion of IGFs in lung cancer cell lines. The production of IGF-binding proteins which were also produced by lung cancer cell lines modifies the autocrine/paracrine model for IGFs since then proteins can either enhance or inhibit the effect of IGFs on tumor growth.
Havemann
K
K
Department of Internal Medicine, Philipps-University Marburg, F.R.G.
Rotsch
M
M
Schöneberger
H J
HJ
Erbil
C
C
Hennig
C
C
Jaques
G
G
D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008175:Lung Neoplasms / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II