[The effect of exogenous prostaglandins E1 and F2 alpha on the adenosine triphosphatase activity in the ileal mucosa of rats].
The influence of exogenous PG E1 and PG F2 alpha on the Na-K- and HCO3-ATPase activities was studied in the rat ileum mucosa pretreated for 3 days with the PG biosynthesis inhibitors: indometacin, dexason, vitamin E. The blockade of the PG biosynthesis increased the activity of both ATPases. Administration of PG E1 and PG F2 alpha inhibited the activity of HCO-3--ATPase and either did not affect the Na-K-ATPase activity (PG E1) or increased it (PG F2 alpha). The prostaglandins seem to participate in the electrolyte transport processes via the ATPase activity modulation.
Dolmatova
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D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D027321:Anion Transport Proteins; D001639:Bicarbonates / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D015237:Dinoprost / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007082:Ileum / Q000187:drug effects* / Q000201:enzymology; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D011448:Prostaglandin Antagonists; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D027321:Anion Transport Proteins; D001639:Bicarbonates; D011448:Prostaglandin Antagonists; D014810:Vitamin E; D003907:Dexamethasone; D015237:Dinoprost; D000251:Adenosine Triphosphatases; C031652:anion-sensitive ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D000527:Alprostadil; D007213:Indomethacin
Vliianie ékzogennykh prostaglandinov E1 i F2 al'fa na aktivnost' adenozintrifosfataz v slizistoĭ obolochke podvzdoshnoĭ kishki krys.