Experimental infection of African green monkeys and cynomolgus monkeys with a SIVAGM strain isolated from a healthy African green monkey.
An infection occurred in all African green monkeys and cynomolgus monkeys experimentally inoculated with SIVAGM [TYO-1], as demonstrated by the appearance of an antibody to SIVAGM [TYO-1] and the isolation of the virus. No monkey exhibited overt clinical disorders throughout the experimental period of 42 weeks. Thus, SIVAGM was not pathogenic to its original host or to macaques. This system is proposed as a model for HIV infection manifesting no overt disease.
Honjo
S
S
Tsukuba Primate Center for Medical Science, National Institute of Health, Tsukuba-shi, Japan.
Narita
T
T
Kobayashi
R
R
Hiyaoka
A
A
Fujimoto
K
K
Takasaka
M
M
Sakakibara
I
I
Mukai
R
R
Ishikawa
K
K
Ohta
Y
Y
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002521:Cercopithecus; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D005260:Female; D015658:HIV Infections; D008198:Lymph Nodes / Q000382:microbiology; D008214:Lymphocytes / Q000382:microbiology; D008251:Macaca; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases; D012192:Retroviridae Infections / Q000662:veterinary; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D013154:Spleen / Q000382:microbiology
D000914:Antibodies, Viral; D000956:Antigens, Viral