Cell line of mouse malignant fibrous histiocytoma with spontaneous metastatic potential.
A new murine malignant fibrous histiocytoma (MFH) cell line was established from a 4-hydroxyaminoquinoline 1-oxide-induced MFH. This cell line was followed by a contiguous sheet, and a confluent monolayer was established after 12 days incubation. These cells could be serially transplanted into the subcutaneous tissue of mice, the success rate becoming 100% after the 9th passage. Transplanted tumors demonstrated rapid growth and displayed a high potential for metastasis to the lung after the 16th passage. And a 100% lung metastasis rate was observed for MFH cells after the 20th passage. Histologically, these metastatic tumors retained features of the primary tumor.
Yamamoto
H
H
Department of Pathology, Kohno Clinical Medicine Research Institute, Tokyo.
Fujishiro
K
K
Yamamoto
I
I
D015108:4-Hydroxyaminoquinoline-1-oxide; D000818:Animals; D002461:Cell Line, Transformed; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced / Q000473:pathology* / Q000556:secondary; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000556:secondary; D051379:Mice; D009368:Neoplasm Transplantation
D015108:4-Hydroxyaminoquinoline-1-oxide