Immunotoxic effects of hexachlorobenzene on the pathogenesis of systemic, pneumonic and hepatic virus infections in the mouse.
A quantitative histopathological method has been developed for the evaluation of the effects of hexachlorobenzene (HCB) on the pathogenesis of three virus infections in the mouse. Hexachlorobenzene was selected because a substantial amount of immunotoxicological data already exists with which we could compare our results. To establish the validity of the method a systemic virus infection (mouse cytomegalovirus, MCMV), a pneumonia causing virus (pneumonia virus of mice, PVM) and a hepatitis virus (mouse hepatitis virus, MHV) were used. We have compared the existing data with the actual pathological effects of hexachlorobenzene on virus disease processes, to gain a more realistic idea of the value of the risk assessment to be derived from extrapolating the in-vitro data in particular, to the in-vivo situation. The results show that the data derived from previous studies on the immunotoxicity of HCB were accurate in predicting the exacerbation of the viral hepatitis, especially in immunodeficient athymic 'nude' mice. It is proposed that this histopathological technique could be a useful technique in the evaluation of host resistance changes following exposure to potentially immunotoxic compounds, but caution will have to be exercised in interpretation in relation to human disease.
Carthew
P
P
MRC Toxicology Unit, MRC Laboratories, Carshalton, Surrey, UK.
Edwards
R E
RE
Smith
A G
AG
D000818:Animals; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000139:chemically induced / Q000473:pathology; D006581:Hexachlorobenzene / Q000633:toxicity*; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000187:drug effects / Q000472:pathogenicity; D014774:Virulence / Q000187:drug effects; D014777:Virus Diseases / Q000139:chemically induced* / Q000276:immunology
D006581:Hexachlorobenzene