Effects of isosorbide dinitrate on the pattern of arterial blood flow in healthy human subjects.
1. Blood velocity measurements have been made in the superficial femoral artery, 10 cm downstream of the common femoral artery bifurcation, in healthy human subjects, using a multi-channel Doppler ultrasound device. 2. In a randomized double-blind protocol, the effects of isosorbide dinitrate were examined during a 2 h period. 3. The changes induced by isosorbide dinitrate include: (i) an increase in the width of the artery and a reduction in brachial arterial blood pressure, implying relaxation of arterial smooth muscle; (ii) an increase in reverse flow and a decrease in time-averaged mean velocity associated with a relatively small decrease of the velocity excursion during the cardiac cycle, implying an increase in flow pulsatility; and (iii) an alteration of the flow pattern both in the core and near the vessel walls.
Caro
C G
CG
Physiological Flow Studies Unit, Imperial College, London.
Fish
P J
PJ
Goss
D E
DE
Halls
J
J
Lever
M J
MJ
Parker
K H
KH
Clear
A S
AS
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects*; D013997:Time Factors; D014463:Ultrasonography
D007548:Isosorbide Dinitrate