Genetic effects of marijuana.
Marijuana and its constitutive cannabinoids--tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD)--markedly affect mammalian cells. Cytogenetic studies have revealed that cannabinoids induce chromosome aberrations in both in vivo and in vitro studies. These aberrations include chromosomal breaks, deletions, translocations, errors in chromosomal segregation, and hypoploidy, and are due to the clastogenic action of cannabinoids or to cannabinoid-induced disruption of mitotic events or both. Conflicting reports of the cytogenetic effects of cannabinoids are partially explained by the different experimental protocols, cell types, and animals used by investigators. Cannabinoids also suppress macromolecular synthesis (DNA, RNA, and protein) as well as reduce the level of histone gene expression. In general these studies show that cannabinoids are detrimental to the health of an individual.
Zimmerman
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Division of Natural Science, Glendon College, York University, Toronto, Ontario, Canada.
Zimmerman
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D000014:Abnormalities, Drug-Induced / Q000235:genetics; D000818:Animals; D002186:Cannabinoids / Q000009:adverse effects*; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D013759:Dronabinol / Q000009:adverse effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D002189:Marijuana Abuse / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D011247:Pregnancy
D002186:Cannabinoids; D013759:Dronabinol