Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol.
In a punished drinking test in rats sclareol glycol (SG) decreased the number of punished responses ("proconflict response") while diazepam had the opposite effect; SG antagonized the "anticonflict response" of diazepam. Post-training administration of SG in rats enhanced retention in active avoidance task evaluated 24 h later. SG produced an increase in plasma ACTH and corticosterone levels in unstressed rats. The stress-induced increase in ACTH and corticosterone secretion was potentiated by SG. All these data suggest that SG behaves as an anxiogenic, memory-facilitator and perhaps adaptogenic agent. The effects of SG may be mediated by different mechanisms of action (stimulation of adenylate cyclase, interaction with GABA-ergic and dopaminergic transmitter mechanisms).
Georgieva
J
J
Institute of Pharmacology and Pharmacy, Bulgarian Medical Academy, Sofia.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D001362:Avoidance Learning / Q000187:drug effects; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D003975:Diazepam / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D013315:Stress, Psychological / Q000188:drug therapy* / Q000523:psychology
D004224:Diterpenes; D000324:Adrenocorticotropic Hormone; D003975:Diazepam; D003345:Corticosterone; C060464:sclareol glycol