title: [Determination of the activity of broad-spectrum antibiotics against Mycobacterium fortuitum by the agar diffusion method].
abstract: Rapidly growing M. fortuitum bring about such conditions in man, like mycobacterioses. Management of patients presents a problem since potentially pathogenic mycobacteria are highly resistant to most antituberculous drugs. To find effective antibacterial drugs for the treatment of human patients, the definition of sensitivity of M. fortuitum to broad--spectrum antibiotics by agar disk-diffusion method on Soton's medium was carried out. Sensitivity of 53 strains of mycobacteria to 13 drugs was investigated. It was demonstrated that the aminoglycoside group (gentamicin, kanamycin and monomycin inhibiting the growth of 96, 98 and 76% % of the strains, respectively) had been the most active. Tetracycline, ristomycin and erythromycin actively affected 35-15% of the tested strains. The agar disk-diffusion method is easy to handle and use in laboratory conditions.
authors.forename: T F
authors.initials: TF
authors.lastname: Otten
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology; D015643:Erythromycin Ethylsuccinate / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D007612:Kanamycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D015643:Erythromycin Ethylsuccinate; D012310:Ristocetin; D007612:Kanamycin; D004917:Erythromycin; D013752:Tetracycline
vernacular_title: Opredelenie aktivnosti antibiotikov shirokogo spektra deĭstviia protiv Mycobacterium fortuitum metodom diffuzii v agare.