Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons.
Systemic administration of pilocarpine to rats induces seizures that resemble complex partial epilepsy in humans. Susceptibility to these seizures is increased by lesion of the GABAergic striatonigral projection. Transplantation of fetal GABAergic neurons, but also of control non-GABAergic tissue, to the deafferent substantia nigra can reduce such lesion-increased seizure susceptibility. These observations are consistent with prior evidence that GABAergic basal ganglia outflow plays an important role in controlling the spread of seizures, and raise the possibility that intracerebral grafts may be of use for therapy of medically-unresponsive epilepsies.
Fine
A
A
Department of Physiology, Dalhousie University School of Medicine, Halifax, Nova Scotia, Canada.
Meldrum
B S
BS
Patel
S
S
D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000503:physiopathology*; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D005333:Fetus; D007696:Kindling, Neurologic / Q000502:physiology; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology; D011699:Putamen / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology*
D011963:Receptors, GABA-A; D010862:Pilocarpine