title: Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus.
abstract: The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
authors.affiliation: Dipartimento Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Tancredi
authors.forename: C
authors.initials: C
authors.lastname: Zona
authors.forename: F
authors.initials: F
authors.lastname: Velotti
authors.forename: F
authors.initials: F
authors.lastname: Eusebi
authors.forename: A
authors.initials: A
authors.lastname: Santoni
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins