Metastatic vulvar Paget's disease responding to combination chemotherapy: case report.
No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.
Yokoyama
Y
Y
Department of Obstetrics and Gynecology, Gifu University School of Medicine.
Mabuchi
M
M
Kawabata
I
I
Niwa
K
K
Shimokawa
K
K
Tamaya
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D002272:Carcinoembryonic Antigen; D008937:Mitomycins; D016685:Mitomycin; D014750:Vincristine; D002945:Cisplatin