Is a high serum cholesterol level associated with longer survival in elderly hypertensives?
The relationship between serum total cholesterol, measured at randomization, and mortality was investigated in 822 patients, who were followed for an average of 3.1 years in a double-blind trial, conducted by the European Working Party on High Blood Pressure in the Elderly. Serum cholesterol, measured at randomization, was 0.54 mmol/l higher in women than in men, and declined with increasing age in both men (0.028 mmol/l per year) and women (0.036 mmol/l per year). During follow-up on randomized treatment, cholesterol fell by a similar amount with placebo (0.11 mmol/l per year) and with active treatment (0.14 mmol/l per year). Active treatment consisted of hydrochlorothiazide (25-50 mg/day) plus triamterene (50-100 mg/day) with the addition of alpha-methyldopa (0.5-2.0 g/day) in one-third of the patients. Serum total cholesterol, measured at randomization, was independently and inversely correlated with total (P = 0.03), non-cardiovascular (P = 0.03) and cancer (P = 0.04) mortality during follow-up on double-blind treatment. Total and non-cardiovascular mortality were also negatively correlated with haemoglobin and body weight at randomization.
Staessen
J
J
Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde-Cardiologie, U.Z. Gasthuisberg, Leuven, Belgium.
Amery
A
A
Birkenhäger
W
W
Bulpitt
C
C
Clement
D
D
de Leeuw
P
P
Deruyttere
M
M
De Schaepdryver
A
A
Dollery
C
C
Fagard
R
R
D000368:Aged; D002784:Cholesterol / Q000097:blood*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D013997:Time Factors; D014223:Triamterene / Q000627:therapeutic use
D006852:Hydrochlorothiazide; D008750:Methyldopa; D002784:Cholesterol; D014223:Triamterene