Induction of heterotypic virus resistance in adult inbred mice immunized with a variant of Coxsackievirus B3.
Infection of adult male C3H/HeJ mice with a host range variant of Coxsackievirus B3 (CB3W-RD) induced resistance in these mice to an otherwise lethal dose of Coxsackievirus B1 (CB1). The protective effect induced by CB3W-RD was detectable as early as 1 day post-vaccination and was still present 10 weeks later. While untreated mice infected with CB1 died within 5 days because of massive hepatic necrosis, the liver was spared in mice immunized with CB3W-RD and then challenged with CB1. In general, CB1 titers in heart, liver, and pancreas of CB3W-RD-vaccinated animals were lower than that found in unvaccinated animals. Virus neutralizing antibody was not a mediator of this heterotypic, virus-induced protective effect. In addition, the outcome of CB1 infection could be modified if superinfection with CB3W-RD took place within 1-4 days following CB1 infection. In this regard, maximum therapeutic efficacy was observed when CB1 infected mice were superinfected 2 days after CB1 infection. CB1-infected mice that survived as a result of treatment with CB3W-RD exhibited liver regeneration but did develop myocardial necrosis.
Landau
B J
BJ
Department of Microbiology and Immunology, Hahnemann University School of Medicine, Philadelphia, PA 19102.
Whittier
P S
PS
Finkelstein
S D
SD
Alstein
B
B
Grun
J B
JB
Schultz
M
M
Crowell
R L
RL
D000818:Animals; D003384:Coxsackievirus Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D029822:Enterovirus B, Human / Q000276:immunology* / Q000302:isolation & purification; D007694:Killer Cells, Natural / Q000276:immunology; D008099:Liver / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009500:Neutralization Tests; D010179:Pancreas / Q000473:pathology; D014611:Vaccination