Effects of B4 Coxsackievirus infection on cell-mediated immunity, natural cytotoxicity and interleukin-1 production by spleen cells, in mice.
By using CBA inbred mice as responders, the influence of in vivo B4 Coxsackievirus infection (in two separate experimental procedures) on anti-virus cell-mediated immunity (CMI), natural killer (NK) cell activity and lipopolysaccharide (LPS) induced interleukin-1 (IL-1) production in spleen cells were studied. Both experimental infection schedules were able to induce a "positive" CMI response. NK cell activity was also significantly stimulated, especially by the administration of high virus amounts/inoculum, with frequent injections. On the contrary, LPS-dependent IL-1 synthesis increased particularly following application of the other experimental schedule (low virus amounts, few injections). Some aspects concerning CMI, NK and IL-1 relationships, during several enteroviral diseases, are discussed.
Voiculescu
C
C
Faculty of Medicine Craiova, Chair of Microbiology, Craiova, Romania.
Rogoz
S
S
Roşu
L
L
Medeşan
C
C
Olinescu
A
A
D000818:Animals; D002464:Cell Migration Inhibition; D003384:Coxsackievirus Infections / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D029822:Enterovirus B, Human; D004926:Escherichia coli; D007111:Immunity, Cellular / Q000276:immunology; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D008070:Lipopolysaccharides