title: Stimulation of growth hormone and corticotropin release by angiotensin II in man.
abstract: The intravenous (IV) infusion of angiotensin II (AII) was administered to seven healthy male volunteers in a randomized placebo-controlled study. As expected, AII induced a significant increase in blood pressure and plasma aldosterone concentrations. AII caused a significant increase in corticotropin (ACTH) and growth hormone (GH) release, but had no effect on the release of thyrotropin (TSH) and prolactin (PRL). These findings suggest that peripherally circulating AII might influence ACTH and GH secretion in humans.
authors.affiliation: Institute of Clinical Medicine, University of Ferrara, Italy.
authors.forename: E C
authors.initials: EC
authors.lastname: degli Uberti
authors.forename: G
authors.initials: G
authors.lastname: Trasforini
authors.forename: A
authors.initials: A
authors.lastname: Margutti
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: M R
authors.initials: MR
authors.lastname: Ambrosio
authors.forename: R
authors.initials: R
authors.lastname: Pansini
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone