Active tyrosine phosphatase in immunoprecipitates of multiple isoforms of Ly-5.
Using tumour cell lines expressing specific isoforms of murine Ly-5 (molecular weights of 180,000, 200,000 and 240,000) we find that all forms of Ly-5 and immuno-affinity purified forms of Ly-5 contain tyrosyl phosphatase activity. These results demonstrate that these isoforms of Ly-5 belong to the same family of functional receptor-linked tyrosine phosphatases as the human leukocyte common antigen. CD45.
Southey
M C
MC
St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Gonez
L J
LJ
Sandrin
M S
MS
Kemp
B E
BE
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D000943:Antigens, Differentiation / Q000302:isolation & purification / Q000378:metabolism*; D000950:Antigens, Ly / Q000302:isolation & purification / Q000378:metabolism*; D002645:Chickens; D006649:Histocompatibility Antigens / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D017493:Leukocyte Common Antigens; D051379:Mice; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011233:Precipitin Tests; D017027:Protein Tyrosine Phosphatases; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000950:Antigens, Ly; D006649:Histocompatibility Antigens; D010749:Phosphoprotein Phosphatases; D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases