title: Failure of (+)-naloxone to accelerate feline colonic transit.
abstract: To determine whether the colonic transit accelerating effect of (-)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.), was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
authors.forename: B
authors.initials: B
authors.lastname: Krevsky
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
authors.forename: A
authors.initials: A
authors.lastname: Cowan
mesh_terms: D000818:Animals; D002415:Cats; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D009270:Naloxone / Q000493:pharmacokinetics / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone