A nonlinear three-compartment model for the administration of 2',3'-dideoxycytidine by using red blood cells as bioreactors.
A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2',3'-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Numerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.
Solimano
F
F
Istituto di Biomatematica, Universita' di Urbino, Italy.
Bischi
G I
GI
Bianchi
M
M
Rossi
L
L
Magnani
M
M
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004912:Erythrocytes / Q000378:metabolism; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008954:Models, Biological; D016047:Zalcitabine / Q000008:administration & dosage* / Q000097:blood
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016047:Zalcitabine