title: Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram.
abstract: Citalopram, a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.
authors.affiliation: Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205-2179.
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: H T
authors.initials: HT
authors.lastname: Ravert
authors.forename: A A
authors.initials: AA
authors.lastname: Wilson
authors.forename: H N
authors.initials: HN
authors.lastname: Wagner
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D015283:Citalopram; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D014179:Neurotransmitter Uptake Inhibitors; D012701:Serotonin; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D014179:Neurotransmitter Uptake Inhibitors; D015283:Citalopram; D012701:Serotonin