Microsomal activation and increased production of 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide (m-AMSA)-dependent, topoisomerase-associated DNA lesions in nuclei from human HL-60 leukemia cells.
Gorsky
L D
LD
Department of Pharmacology, Northwestern University, Chicago, IL 60611.
Morin
M J
MJ
D000677:Amsacrine / Q000494:pharmacology*; D002467:Cell Nucleus; D004249:DNA Damage; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D000677:Amsacrine; D004250:DNA Topoisomerases, Type II