[Biodistribution of new polynitroxides using electron paramagnetic resonance].
The most important paramagnetic contrast agents used in Nuclear Magnetic Resonance Imaging are limited to a few metal complexes such Gd-DTPA or stable free radicals such as nitroxides simply functionalized. We studied the biodistribution of new polynitroxides agents by Electronic Paramagnetic Resonance in Sprague Dawley rats. Three of the six different polynitroxides agents studied, showed an interesting and selective localisation in the lungs, heart and liver.
Brik
M E
ME
Laboratoire de Chimie Structurale Organique, Université Paris-Sud, Orsay.
Pechine
J M
JM
Courtieu
J
J
Lecayon
M
M
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009589:Nitrogen Oxides / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013113:Spin Labels; D014018:Tissue Distribution
D009589:Nitrogen Oxides; D013113:Spin Labels
Biodistribution de nouveaux polynitroxydes par résonance paramagnétique électronique.