[Physiological functions of (Na+ + K+)-adenosinetriphosphatase (ATPase) isozymes].
Since Sweadner demonstrated that there are two isozymes (alpha and alpha(+) isoforms) of (Na+ + K+)-adenosine triphosphatase (ATPase) in the brain about 10 years ago, the isozymes have been extensively studied at biochemical and molecular levels. We started the studies on the isozymes of (Na+ + K+)-ATPase soon after finding that pyrithiamin, an antimetabolite of thiamin is a selective inhibitor of the alpha(+)isoform. This review summarizes the previous studies on the isozymes of (Na+ + K+)-ATPase, which are now classified into alpha 1, alpha 2, and alpha 3.
Matsuda
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
D000818:Animals; D001921:Brain / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism / Q000502:physiology*; D007668:Kidney / Q000201:enzymology; D008968:Molecular Conformation; D009206:Myocardium / Q000201:enzymology; D010042:Ouabain / Q000494:pharmacology; D010766:Phosphorylation; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*
D007527:Isoenzymes; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase