Postinitiation transcriptional control in Drosophila melanogaster.
Drosophila hsp70 genes have an RNA polymerase II molecule paused at their 5' ends in uninduced cells. In this study we have shown that this pausing also occurs on other heat shock and constitutively expressed genes. We propose that a rate-limiting step in early elongation occurs in many Drosophila genes and may be a target for transcriptional regulation.
Rougvie
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Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853.
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JT
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D006360:Heat-Shock Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012319:RNA Polymerase II / Q000378:metabolism; D015183:Restriction Mapping; D014158:Transcription, Genetic; D014452:Ubiquitins / Q000235:genetics
D006360:Heat-Shock Proteins; D014452:Ubiquitins; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases