title: The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity.
abstract: Cocaine is a widely used drug of abuse. One of the characteristic effects of this stimulant drug in the CNS of mice is the induction of motor hyperactivity. It was demonstrated that cocaine-induced motor hyperactivity could be blocked by pimozide, a dopamine receptor blocker, suggesting that dopamine was involved in cocaine-induced hyperactivity. Oxytocin, a neurohypophyseal neuropeptide, also partially antagonized cocaine-induced motor hyperactivity. Moreover, oxytocin antagonized the increased utilization of dopamine, elicited by cocaine in the nucleus accumbens. The data suggest that oxytocin may influence the behavioural effects of cocaine by affecting dopaminergic neurotransmission in some regions of the brain.
authors.affiliation: Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: G L
authors.initials: GL
authors.lastname: Kovàcs
authors.forename: Z
authors.initials: Z
authors.lastname: Sarnyai
authors.forename: E
authors.initials: E
authors.lastname: Barbarczi
authors.forename: G
authors.initials: G
authors.lastname: Szabó
authors.forename: G
authors.initials: G
authors.lastname: Telegdy
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D019805:alpha-Methyltyrosine
chemical_list: D008781:Methyltyrosines; D010121:Oxytocin; D019805:alpha-Methyltyrosine; D003042:Cocaine; D004298:Dopamine