title: Scintigraphy with nanocolloid Tc 99m in patients with small cell lung cancer, with special reference to bone marrow and hepatic metastasis.
abstract: Nineteen patients with newly diagnosed small cell lung cancer (SCLC) were examined with a nanocolloid Tc-99m bone marrow whole body imaging (scintigraphy) in order to detect bone marrow metastasis. Bilateral bone marrow biopsy taken from the posterior iliac crest was used as a reference. The scintigraphy was considered abnormal if a focal lesion was present and/or if the bone marrow activity expanded to more than one-third of the proximal part of the extremities. In 3 of the 19 patients, microscopical bone marrow metastasis and cold spots (focal lesions) on the scintigram were present. An additional 9 patients had expansion of the activity. Eight patients showed scintigraphic focal lesions in the liver. SCLC metastasis was confirmed in 4 patients, while 1 patient had focal necroses. The results indicate that cold spots rather than expansion of activity with bone marrow scintigraphy detected bone marrow involvement of the disease in patients with SCLC.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, ONK' Finsen Institute, Rigshospitalet, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Widding
authors.forename: I
authors.initials: I
authors.lastname: Stilbo
authors.forename: S W
authors.initials: SW
authors.lastname: Hansen
authors.forename: H H
authors.initials: HH
authors.lastname: Hansen
authors.forename: N
authors.initials: N
authors.lastname: Rossing
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000556:secondary*; D003102:Colloids; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D003102:Colloids; D013667:Technetium