title: Decreased cyclic nucleotide phosphodiesterase activity in human peripheral blood mononuclear cells from elderly women.
abstract: 1. Both adenosine 3':5'-cyclic monophosphate and guanosine 3':5'-cyclic monophosphate phosphodiesterase activities of peripheral blood mononuclear cells were markedly decreased in elderly women as compared with young control women. 2. In contrast, the ability of these cells to bind guanosine 5'-[beta, gamma-imido]triphosphate, a non-hydrolysable analogue of guanosine 5'-triphosphate, was the same in both groups. 3. These findings are discussed in the context of the decline in immune function which occurs with increasing age.
authors.affiliation: Unité INSERM 205, Institut National des Sciences Appliquées, Villeurbanne, France.
authors.forename: N
authors.initials: N
authors.lastname: Meskini
authors.forename: O
authors.initials: O
authors.lastname: Macovschi
authors.forename: A F
authors.initials: AF
authors.lastname: Prigent
authors.forename: G
authors.initials: G
authors.lastname: Nemoz
authors.forename: P
authors.initials: P
authors.lastname: Chapuy
authors.forename: M
authors.initials: M
authors.lastname: Lagarde
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology*
chemical_list: D000242:Cyclic AMP; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D006152:Cyclic GMP