title: Carcinosarcoma arising in eccrine spiradenoma. A clinicopathologic and immunohistochemical study of two cases.
abstract: Malignant change in a benign eccrine spiradenoma is rare. Only 13 such cases have been previously reported. Two further cases are described herein, both of which were carcinosarcomas and arose in middle-aged women. In each case continuity was demonstrated between the benign and malignant epithelial components and the sarcomatous element. In case 1 the sarcomatous component showed osteocartilaginous and rhabdomyoblastic differentiation, whereas in case 2 only osteosarcoma was evident. To our knowledge, carcinosarcoma has not been previously described arising in eccrine spiradenoma. The literature regarding malignant eccrine spiradenoma is reviewed.
authors.affiliation: Department of Histopathology, St. Thomas's Hospital Medical School, London, England.
authors.forename: P H
authors.initials: PH
authors.lastname: McKee
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
authors.forename: P
authors.initials: P
authors.lastname: Stavrinos
authors.forename: H
authors.initials: H
authors.lastname: Pambakian
mesh_terms: D006607:Adenoma, Sweat Gland / Q000032:analysis / Q000473:pathology*; D002296:Carcinosarcoma / Q000032:analysis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013544:Sweat Gland Neoplasms / Q000032:analysis / Q000473:pathology*