Cloning and sequencing of the human c-abl 3' untranslated region.
The human c-abl oncogene gives rise to different mRNA transcripts which vary primarily in that they possess alternative first exons. In the present study, we present the sequence for the human c-abl 3' untranslated region (3'utr) and show that while human and murine c-abl cDNA sequences are generally homologous, human c-abl transcripts unlike the murine c-abl transcripts do not differ significantly in their 3' utrs.
Andrews
D F
DF
Department of Medicine (III), VA Medical Center, Seattle, WA 98108.
Tompkins
C K
CK
Hendrickson
S L
SL
Singer
J W
JW
D001483:Base Sequence; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D014158:Transcription, Genetic
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; D016315:Proto-Oncogene Proteins c-abl