title: DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.
abstract: In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.
authors.affiliation: CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Dazzi
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
authors.forename: P S
authors.initials: PS
authors.lastname: Hasleton
authors.forename: R
authors.initials: R
authors.lastname: Swindell
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D004273:DNA, Neoplasm; D066246:ErbB Receptors