Preparation of new 7-hydroxyguanine derivatives and their biological activities.
We prepared new 7-hydroxyguanine derivatives, 7-hydroxyguanosine 5'-monophosphate and N2-tetrahydropyranyl-7-hydroxyguanine, and compared biological activities of 7-hydroxyguanine derivatives including nucleosides acquired previously. 7-Hydroxyguanine and its nucleotide inhibited the focus formation of Rous sarcoma virus. Antitumor activities of these derivatives against mouse leukemia L1210 were not so different from one another. Anti-proliferative activities of the derivatives on various human cell lines were significantly different from one another.
Kitahara
M
M
Biochemical Research Laboratories, Kanegafuchi Chemical Industry Co., Ltd., Hyogo, Japan.
Shinjyo
K
K
Fukae
M
M
Hosoe
K
K
Shiraishi
T
T
Ishii
K
K
Watanabe
K
K
Kawaharada
H
H
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D006150:Guanine Nucleotides / Q000138:chemical synthesis*; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured / Q000187:drug effects
D006150:Guanine Nucleotides; D011714:Pyrans; C064489:N(2)-tetrahydropyranyl-7-hydroxyguanine; C064490:7-hydroxyguanosine 5'-monophosphate; D006147:Guanine; D006157:Guanosine Monophosphate