[Possible role of 06-methylguanine-DNA-transferase in the response of patients with primary tumor of the brain to chemotherapy using chloro-ethyl-nitroso-urea: results of a current study].
We have started a study to measure the MT activity in surgical specimens from high grade human malignant gliomas, with the dual aim to (i), know whether lack of activity can be demonstrated in these tumors, and (ii), relate the measured levels of MT to the histology of the tumors and to the response of patients to chemotherapy with 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU). To date, 12 Gliomas have been assayed. In 11 tumors, MT activities ranging from 30 to 150 fmoles/mg protein have been measured. The only negative specimen derived from a patient who had received radiotherapy before surgery. At the present stage of the study, therefore, we have no unequivocal evidence for the existence of MT-deficient Gliomas.
Arena
G
G
Laboratorio di Mutagenesi, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova.
Abbondandolo
A
A
Rossi
O
O
Gentile
S L
SL
Bruzzone
E
E
Francaviglia
N
N
Capellini
C
C
D001254:Astrocytoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use*; D008297:Male; D008780:Methyltransferases / Q000378:metabolism*; D009367:Neoplasm Staging; D019853:O(6)-Methylguanine-DNA Methyltransferase
D008130:Lomustine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase
Possible ruolo della 06-metilguanina-DNA-Transferasi nella risposta di pazienti con tumori cerebrali primitivi alla chemioterapia con Cloro-Etil-Nitroso-Uree: risultati di uno studio in corso.