title: Cytomegalovirus cultures during maintenance DHPG therapy for cytomegalovirus (CMV) retinitis in acquired immunodeficiency syndrome (AIDS).
abstract: Nine patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis on maintenance therapy with ganciclovir: 9(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) at high dose (30 mg/kg/week) or low dose (20 mg/kg/week) were tested every 1-2 weeks for CMV isolation from blood, saliva, and urine. Duration of therapy ranged from 1.5 to 12 months (average 5.3 months). During pretreatment and low-dose and high-dose maintenance therapy, CMV was isolated from 48/59 (81%), 90/211 (43%), and 40/290 (14%) of specimens, respectively. Three patients with progressive retinitis had viraemia more frequently than did six patients with stable retinitis, CMV being isolated from 29/47 (62%) and 17/121 (14%) of blood samples, respectively.
authors.affiliation: Department of Medicine, Fairfield Infectious Diseases Hospital, Victoria, Australia.
authors.forename: I D
authors.initials: ID
authors.lastname: Jennens
authors.forename: C R
authors.initials: CR
authors.lastname: Lucas
authors.forename: A M
authors.initials: AM
authors.lastname: Sandland
authors.forename: H
authors.initials: H
authors.lastname: Maclean
authors.forename: K
authors.initials: K
authors.lastname: Hayes
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D000328:Adult; D003587:Cytomegalovirus / Q000187:drug effects / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy*; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012173:Retinitis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D014766:Viremia / Q000150:complications / Q000188:drug therapy
chemical_list: C040342:9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate; D006160:Guanosine Triphosphate