Regulatory functions of protein kinase C in glomerular mesangial cells.
Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function.
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Ciba-Geigy Ltd., Research Department, Basel, Switzerland.
D004075:Diglycerides / Q000378:metabolism; D004789:Enzyme Activation; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis; D011493:Protein Kinase C / Q000494:pharmacology*
C011439:1,2-diacylglycerol; D004075:Diglycerides; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D011453:Prostaglandins; D015544:Inositol 1,4,5-Trisphosphate; D011493:Protein Kinase C; D010741:Phospholipases A