Nuclear receptor that identifies a novel retinoic acid response pathway.
Molecular cloning and transcriptional activation studies have revealed a new protein similar to the steroid hormone receptors and which responds specifically to vitamin A metabolites. This protein is substantially different in primary structure and ligand specificity from the products of the previously described retinoic acid receptor gene family. By indicating the existence of an additional pathway through which retinoic acid may exert its effects, these data lead to a re-evaluation of retinoid physiology.
Mangelsdorf
D J
DJ
Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92138-9216.
Ong
E S
ES
Dyck
J A
JA
Evans
R M
RM
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D015723:Gene Library; D006801:Humans; D007256:Information Systems; D008297:Male; D008969:Molecular Sequence Data; D009928:Organ Specificity; D051381:Rats; D018168:Receptors, Retinoic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology*
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D004247:DNA