Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning.
In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-D-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (-) MK 801 was without effect. The results indicate that the N-methyl-D-aspartate receptor exerts a permissive role on priming.
Morelli
M
M
Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Italy.
Di Chiara
G
G
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000037:antagonists & inhibitors*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000502:physiology; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects*; D013563:Sympathectomy, Chemical; D009435:Synaptic Transmission / Q000187:drug effects*
D003986:Dibenzocycloheptenes; D006892:Hydroxydopamines; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D016291:Dizocilpine Maleate; D016627:Oxidopamine; D001058:Apomorphine