Comparison of a human granular cell tumour (myoblastoma) with granular cell tumours (meningiomas) of the rat meninges--an immunohistological and ultrastructural study.
A single human granular cell tumour (myoblastoma) was compared with seven rat granular cell tumours (meningiomas) of the meninges. The comparison was made histologically, ultrastructurally and using immunocytochemical markers. A selection of antibodies to histiocytic, muscle, neural, neural crest and mesenchymal antigens was used. Histogenesis of both the human and rat tumours from neural crest-derived cells was evident and it is suggested that the term 'meningioma' for these rat tumours is a misnomer.
Wright
J A
JA
Department of Pathology, ICI Pharmaceuticals, Macclesfield, Cheshire, U.K.
Goonetilleke
U R
UR
Waghe
M
M
Stewart
M
M
Carlile
A
A
D000818:Animals; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D008579:Meningioma / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D008854:Microscopy, Electron; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000648:ultrastructure*