title: [Aspergillus mastoiditis in infected granulomatosis--a case report].
abstract: An 11-year old boy with chronic granulomatous disease due to cytochrome B deficiency developed pulmonary aspergillosis proven by culture in his upper right lobe (upper lobe resection). In spite of maximum doses of flucytosin/amphotericin B combination, he developed focal seizures associated with three intracerebral lesions and a lesion in the area of the right mastoid. Imaging methods (X-ray Schüller, CT, MRT) demonstrated the defects. Mastoidectomy showed blue purulent but sterile necrosis. The antimycotic therapy with the Flucytosin/Amphotericin B combination was stopped and replaced by a new drug, itraconazole. After a short time the boy felt much better. Even the intracerebral lesions became smaller. We conclude that both the surgical and the conservative therapy with a new antimycotic are the reason for this result.
authors.affiliation: Universitäts-Hals-Nasen-OhrenKlinik Düsseldorf.
authors.forename: J
authors.initials: J
authors.lastname: Lamprecht
authors.forename: A G
authors.initials: AG
authors.lastname: Kühn
authors.forename: S
authors.initials: S
authors.lastname: Sauer
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000601:surgery*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D002648:Child; D003131:Combined Modality Therapy; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008416:Mastoid / Q000473:pathology / Q000601:surgery; D008417:Mastoiditis / Q000188:drug therapy / Q000601:surgery*; D009894:Opportunistic Infections / Q000188:drug therapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole
vernacular_title: Aspergillus-Mastoiditis bei septischer Granulomatose--Ein Fallbericht.