The cytomegalovirus enhancer: a pan-active control element in transgenic mice.
In an effort to identify widely active positive regulatory elements, we have examined the action of the cytomegalovirus enhancer-promoter in transgenic mice. These elements activated expression in 24 of 28 tissues tested. The greatest expression was observed in the heart, kidney, brain, and testis. Maximum expression further localized to specific cells within the heart and kidney.
Schmidt
E V
EV
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115.
Christoph
G
G
Zeller
R
R
Leder
P
P
D000818:Animals; D003587:Cytomegalovirus / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D015967:Gene Expression Regulation, Viral; D006321:Heart / Q000382:microbiology; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D015347:RNA Probes; D015183:Restriction Mapping; D014158:Transcription, Genetic
D015347:RNA Probes