Are some cases of acute leukemia with t(8;21) hybrid leukemias?
Translocations between chromosomes 8 and 21, t(8;21)(q22;q22), occur most commonly in acute myelogenous leukemia (AML) of the M2 FAB type. We studied two cases of acute leukemia with t(8;21) by immune phenotyping and IgH and T-cell receptor beta chain gene rearrangement analyses. These cases had increased blasts in bone marrow (greater than 50%). Auer rods, and evidence of granulocyte maturation. Blasts from both cases expressed CD19(B4), a B-cell antigen, as well as myeloid antigens including CD13(My7) and CD33(My9). HLA-DR, CD34, and TdT were also strongly positive. IgH or TCR beta gene rearrangements were not detected. We suggest that some cases of acute leukemia with t(8;21) may be hybrid leukemias with transformation in a multipotent stem cell.
Sun
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Department of Medicine, UCLA School of Medicine 90024-1678.
Sparkes
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RS
Wormsley
S
S
Naeim
F
F
Champlin
R
R
Gale
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RP
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015139:Blotting, Southern; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D015703:Antigens, CD