Lack of antinociceptive activity of sumatriptan in rodents.
The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.
Skingle
M
M
Department of Neuropharmacology, Glaxo Group Research Ltd, Ware, Herts, UK.
Birch
P J
PJ
Leighton
G E
GE
Humphrey
P P
PP
D000818:Animals; D006168:Guinea Pigs; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*; D018170:Sumatriptan; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D007211:Indoles; D013449:Sulfonamides; D014662:Vasoconstrictor Agents; D018170:Sumatriptan