title: [Is xanthine oxidase a universal source of superoxide radicals in ischemic and reperfusion lesions?].
abstract: While studying xanthine-xanthine oxidase system it was found, that a considerable accumulation of xanthine and uric acid occurred whereas xanthine dehydrogenase did not transfer in xanthine oxidase during 2 hours of total rat liver ischemia. These data make it possible to reject the generally accepted hypothesis of xanthine oxidase key role in free radical mechanism of ischemia damage.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Rashba
authors.forename: L G
authors.initials: LG
authors.lastname: Nagler
authors.forename: L S
authors.initials: LS
authors.lastname: Vartanian
authors.forename: L A
authors.initials: LA
authors.lastname: Oktiabr'skaia
authors.forename: M V
authors.initials: MV
authors.lastname: Bilenko
mesh_terms: D000818:Animals; D002845:Chromatography; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007511:Ischemia / Q000201:enzymology*; D008099:Liver / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D015424:Reperfusion; D013481:Superoxides / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism; D019820:Xanthine; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*; D014970:Xanthines / Q000378:metabolism
chemical_list: D005609:Free Radicals; D007042:Hypoxanthines; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase
vernacular_title: Iavliaetsia li ksantinoksidaza universal'nym istochnikom superoksidnykhradikalov pri ishemicheskom i reperfuzionnom povrezhdeniiakh?