title: Ketone body metabolism in lean male adults during short-term starvation, with particular reference to forearm muscle metabolism.
abstract: 1. Thirty-three arteriovenous forearm catheterization studies were carried out in 19 lean subjects starving for 12-14 h (n = 13), 30-36 h (n = 7) and 60-66 h (n = 13). Forearm blood flow was measured in order to calculate the flux of various substrates. At the same time, whole-body oxidation of fat, carbohydrate and protein was calculated using indirect calorimetry and urinary nitrogen excretion. 2. After an overnight fast (12-14 h), whole-body resting energy expenditure was accounted for by the oxidation of protein (15%), carbohydrate (17%) and fat (68%). At 30-36 h and 60-66 h of starvation, essentially all the non-protein energy was derived from the oxidation of fat (directly plus indirectly via ketone bodies). 3. After an overnight fast, acetoacetate and 3-hydroxybutyrate were taken up by forearm muscle at a rate which could account for 5% of the resting O2 consumption of this tissue. As starvation progressed, forearm muscle took up more acetoacetate and released 3-hydroxybutyrate so that the net uptake of ketone bodies was sufficient to account for about 10% of the resting O2 consumption at 30-36 h of starvation and about 20% at 60-66 h of starvation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dunn Clinical Nutrition Centre, University of Cambridge, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Elia
authors.forename: S
authors.initials: S
authors.lastname: Wood
authors.forename: K
authors.initials: K
authors.lastname: Khan
authors.forename: E
authors.initials: E
authors.lastname: Pullicino
mesh_terms: D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000378:metabolism; D000328:Adult; D005542:Forearm; D006801:Humans; D006885:Hydroxybutyrates / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010101:Oxygen Consumption; D013217:Starvation / Q000378:metabolism*; D013851:Thinness / Q000378:metabolism*
chemical_list: D000090:Acetoacetates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D020155:3-Hydroxybutyric Acid