title: Methylprednisolone pulse therapy in acute severe asthma. A randomized, double-blind study.
abstract: Methylprednisolone pulse therapy (MPPT) has been shown to possess a long-lasting effect in other immune-inflammatory diseases without the well-known side effects caused by long-term treatment with glucocorticosteroids. In an attempt to reduce the long-term use of oral steroids in asthmatics, we conducted this double-blind, double-dummy study to compare the use of MPPT (1 g of methylprednisolone intravenously) (8 patients) with a short course of oral prednisolone (10 patients) in asthmatics presenting with acute severe asthma. Both treatments were effective in relieving the acute attack of asthma. The MPPT-treated patients did not show a faster resolution than did the orally treated group. No patients needed assisted ventilation, and no deaths occurred. One week after the treatment FEV1 tended to decrease in the methylprednisolone group compared with the oral prednisolone group (P = 0.06). The patients initially receiving MPPT needed supplementary prednisolone earlier and in higher doses than did the patients receiving oral prednisolone as initial treatment. At the end of the 12 weeks' study period, the groups reached identical FEV1. In conclusion, we did not find intravenous methylprednisolone superior to oral prednisolone in the treatment of acute attacks of severe asthma, but methylprednisolone pulse therapy had a shorter duration as regards protection against future asthma attacks.
authors.affiliation: Allergy Department 7511, State University Hospital, Copenhagen, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Engel
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: L
authors.initials: L
authors.lastname: Frølund
authors.forename: J H
authors.initials: JH
authors.lastname: Heinig
authors.forename: U G
authors.initials: UG
authors.lastname: Svendsen
authors.forename: B K
authors.initials: BK
authors.lastname: Pedersen
authors.forename: B
authors.initials: B
authors.lastname: Weeke
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D001249:Asthma / Q000188:drug therapy*; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone