title: Incidence of antibodies to human papillomavirus type 1 in patients with cutaneous and mucosal papillomas.
abstract: A study of antibodies to human papillomavirus (HPV) 1 is reported in a series of sera from 126 patients with papilloma lesions of different clinical types (verruca plantaris, vulgaris, plana, condyloma acuminata, laryngeal papilloma) using a sensitive solid-phase enzyme-linked immunosorbent assay (ELISA). Our findings showed a significant prevalence of specific HPV 1 IgG antibodies in patients with plantar warts (65%). This incidence was considerably lower in patients with other papilloma lesions, in which positive sera may reflect a past infection with HPV 1. The ELISA test was evaluated as nearly 100 times more sensitive than the indirect immunofluorescence test, and IgG titers to HPV 1 in patients' sera were usually low. Serum samples taken at different times during the course of HPV infection in a few patients with refractory lesions did not show any significant change in their antibody titer.
authors.affiliation: INSERM U209 affiliée CNRS, Hôpital E. Herriot, Lyon, France.
authors.forename: J
authors.initials: J
authors.lastname: Viac
authors.forename: J J
authors.initials: JJ
authors.lastname: Chomel
authors.forename: Y
authors.initials: Y
authors.lastname: Chardonnet
authors.forename: M
authors.initials: M
authors.lastname: Aymard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007822:Laryngeal Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*; D014860:Warts / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G