RNA virus quasispecies populations can suppress vastly superior mutant progeny.
A variant clone of vesicular stomatitis virus recovered from a high-passage, evolving virus population replicated rapidly and produced remarkably high yields of virus, but these variants never dominated during further passages. We show that this clone is highly competitive, but it can overwhelm its progenitor population only when seeded above threshold level during dilute passages.
de la Torre
J C
JC
Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.
Holland
J J
JJ
D000818:Animals; D002460:Cell Line; D014644:Genetic Variation; D007700:Kinetics; D012328:RNA Viruses / Q000235:genetics* / Q000502:physiology; D013489:Suppression, Genetic; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication