Regulation of high affinity choline uptake.
High affinity uptake of choline, the rate-limiting, regulatory step for the synthesis of acetylcholine (ACh), was found to be regulated via presynaptic auto- and heteroreceptors. The transport rate was reduced by a muscarinic agonist and neuropeptides, but was significantly enhanced by octopamine. Intracellular messengers, including cyclic nucleotides, appear to modulate the transport activity, apparently by activating specific protein kinases.
Breer
H
H
University of Hohenheim, Institute of Zoophysiology, Stuttgart, Federal Republic of Germany.
Knipper
M
M
D000109:Acetylcholine / Q000096:biosynthesis; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology; D001692:Biological Transport; D002794:Choline / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006110:Grasshoppers; D009411:Nerve Endings / Q000378:metabolism*; D010095:Oxotremorine / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D001679:Biogenic Amines; D017981:Receptors, Neurotransmitter; D010095:Oxotremorine; D000242:Cyclic AMP; D011494:Protein Kinases; D002794:Choline; D000109:Acetylcholine