Assay methods for cyclosporine monitoring following liver transplantation.
This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.
Haven
M C
MC
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
Sobeski
L M
LM
Earl
R A
RA
Markin
R S
RS
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003524:Cyclosporins / Q000097:blood*; D005069:Evaluation Studies as Topic; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D016031:Liver Transplantation / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods
D003524:Cyclosporins