Purification and characterization of a calicivirus as the causative agent of a lethal hemorrhagic disease in rabbits.
The causative viral agent of a lethal rabbit hemorrhagic disease has been purified and characterized. In negative-stained preparations, the virions were icosahedral, measured 27 to 35 nm in diameter, were without an envelope, and showed 10 peripheral cup-shaped depressions. The major structural protein was 60 kilodaltons, which constitutes a unique characteristic of the Caliciviridae.
Parra
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Departamento de Biología Funcional (Area de Bioquímica), Facultad de Medicina, Universidad de Oviedo, Spain.
Prieto
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D000818:Animals; D015153:Blotting, Western; D002139:Caliciviridae / Q000302:isolation & purification* / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D006470:Hemorrhage / Q000382:microbiology / Q000662:veterinary*; D008854:Microscopy, Electron; D008970:Molecular Weight; D010850:Picornaviridae Infections / Q000662:veterinary*; D011817:Rabbits; D014764:Viral Proteins / Q000302:isolation & purification; D014771:Virion / Q000302:isolation & purification* / Q000648:ultrastructure
D014764:Viral Proteins