Chloramphenicol modifies benzodiazepine receptor rhythm in the pontomesencephalic formation of the rat.
Pontomesencephalic benzodiazepine (BZ) receptors were measured at 4 h intervals throughout a 24 h day, and compared with those in frontal cortex, using [3H]diazepam binding. Animals were treated with saline, chloramphenicol (CAP) or thiamphenicol (TAP). An ultradian rhythm of receptors was observed in both cases, which was abolished by CAP but not by TAP. Saturation curves and Scatchard analysis indicated decreased binding was due to a decrease in the number of receptors. CAP effect on REM sleep, could be mediated by a general decrease of neurotransmitter receptors at precise periods of the wake-sleep rhythm.
López-Colomé
A M
AM
Departamento de Neurociencias, Universidad Nacional Autónoma de México, D.F.
Drucker-Colín
R
R
D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D003975:Diazepam / Q000378:metabolism*; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013839:Thiamphenicol / Q000494:pharmacology
D011963:Receptors, GABA-A; D002701:Chloramphenicol; D013839:Thiamphenicol; D003975:Diazepam