Coat color genetics of Peromyscus. I. Ashiness, an age-dependent coat color mutation in the deer mouse.
Ashy deer mice (Peromyscus maniculatus) were first discovered about 1960 in a wild population from Oregon. Although indistinguishable from the wild type at weaning, ashy deer mice become progressively grayer with subsequent molts. The trait is inherited as an autosomal recessive and the symbol ahy is assigned for the locus. The trait is distinctly manifest by 6 months of age, at which time homozygotes have white hairs on the muzzle and at the base of the tail. The amount of white gradually increases with age, but development varies greatly among animals. Some become virtually all white by 18 months. Implants of melanocyte-stimulating hormone induced production of pigment in depigmented portions of the coat, indicating that viable melanocytes were present. The ashy deer mouse model may be useful for further study of melanocyte function.
Teed
S K
SK
Department of Biological Sciences, University of South Carolina, Columbia 29208.
Crossland
J P
JP
Dawson
W D
WD
D000375:Aging / Q000235:genetics; D000818:Animals; D016009:Chi-Square Distribution; D003433:Crosses, Genetic; D004343:Drug Implants; D005260:Female; D006200:Hair Color / Q000187:drug effects / Q000235:genetics*; D008297:Male; D008544:Melanocytes / Q000187:drug effects; D009154:Mutation; D010542:Peromyscus / Q000235:genetics*; D010641:Phenotype; D000521:alpha-MSH / Q000008:administration & dosage / Q000494:pharmacology
D004343:Drug Implants; D000521:alpha-MSH