title: A crossover study of lecithin treatment of tardive dyskinesia.
abstract: The authors enrolled 21 patients in a random-order, crossover, double-blind trial of phosphatidylcholine (lecithin) 20 g/day and placebo. Fourteen patients completed at least 6 weeks of the second 8-week trial and were used for efficacy analyses. Side effects were minimal. The lecithin treatment effect--about one half of an Abnormal Involuntary Movement Scale point--was seen as a statistical effect of treatment order, based on differences between patients who took the active compound before or after they took the placebo. Clinically, however, the lecithin effect was negligible.
authors.affiliation: Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gelenberg
authors.forename: D J
authors.initials: DJ
authors.lastname: Dorer
authors.forename: J D
authors.initials: JD
authors.lastname: Wojcik
authors.forename: W E
authors.initials: WE
authors.lastname: Falk
authors.forename: A W
authors.initials: AW
authors.lastname: Brotman
authors.forename: L
authors.initials: L
authors.lastname: Leahy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001294:Attitude to Health; D002794:Choline / Q000097:blood; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010808:Physical Examination; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D011795:Surveys and Questionnaires
chemical_list: D010713:Phosphatidylcholines; D010919:Placebos; D002794:Choline