Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture.
The SF strain of human herpesvirus 6 (HHV-6SF) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.
Levy
J A
JA
Cancer Research Institute, School of Medicine, University of California, San Francisco 94143.
Landay
A
A
Lennette
E T
ET
D002478:Cells, Cultured; D015497:HIV-1 / Q000502:physiology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D014762:Viral Interference / Q000502:physiology; D014779:Virus Replication / Q000502:physiology*