Structure of mouse vasopressin and oxytocin genes.
Mouse vasopressin (VP) and oxytocin (OT) genes were isolated from a genomic library and the nucleotide sequences of the two genes were determined. The two genes have similar three exon structures and a high similarity in the part of exon 1 encoding vasopressin or oxytocin nonapeptide and in exon 2 encoding the central core of neurophysin. They are linked together in a tail to tail orientation separated by a short 3.5 kb intergenic sequence and are transcribed from opposite strands. Both genes have a single transcription initiation site downstream from a TATA-like sequence and a single polyadenylated transcript of about 760 bp for the vasopressin mRNA and about 700 bp for the oxytocin mRNA.
Hara
Y
Y
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Battey
J
J
Gainer
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D008040:Genetic Linkage / Q000235:genetics; D015151:Immunoblotting; D051379:Mice; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010121:Oxytocin / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000037:antagonists & inhibitors; D013045:Species Specificity; D014667:Vasopressins / Q000235:genetics*
D015345:Oligonucleotide Probes; D014667:Vasopressins; D010121:Oxytocin; D015719:Single-Strand Specific DNA and RNA Endonucleases