title: Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis.
abstract: Leukotriene B4 in the skin was remarkably elevated in the rat, but not in the guinea pig or the mouse 48 h after UV-B irradiation. These results were consistent with interspecies difference of PMN infiltration caused by UV-B irradiation. LTB4 in the rat skin was determined by both high-performance liquid chromatography and radioimmunoassay. LTB4 in the rat skin started to increase 24 h after irradiation and became about 65-fold higher in the irradiated site than in the nonirradiated site at the end of 48 h. This elevation was strongly inhibited by topical application of two 5-lipoxygenase inhibitors, AA-861 and piriprost, although the inflammatory reaction or infiltration of polymorphonuclear leukocytes was not much improved.
authors.affiliation: Department of Pharmacology, Kumamoto University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakaguma
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D016227:Benzoquinones; D011464:Epoprostenol / Q000494:pharmacology / Q000031:analogs & derivatives; D006168:Guinea Pigs; D007975:Leukotriene B4 / Q000032:analysis*; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D010787:Photosensitivity Disorders / Q000209:etiology / Q000378:metabolism*; D011809:Quinones / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000032:analysis*; D013045:Species Specificity; D014466:Ultraviolet Rays
chemical_list: D016227:Benzoquinones; D016859:Lipoxygenase Inhibitors; D011809:Quinones; D007975:Leukotriene B4; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D011464:Epoprostenol; C035296:piriprost