title: [The baroreflex component in the mechanism of the hypotensive action of atrial peptides].
abstract: Changes in the arterial pressure (AP), heart rate (HR) and sensitivity of chronotropic baroreceptor reflex (SBR) evoked by i. v. infusion of alpha-ANP, AP-III, AP-II, and AP-I (1 mg/kg/min) were studied in alert Wistar rats. The SBR was tested by infusion of phenylephrine or sodium nitroprusside. All the ANP analogues, except AP-1, were shown to decrease the AP and evoke differential changes in the SBR. The SBR evoked by phenylephrine was increased by 60-80%, whereas SBR evoked by sodium nitroprusside was decreased by 30-60%. The specific changes in tachycardic and bradycardic components of the baroreceptor reflex after ANP analogues infusions seem to reflect participation of the baroreceptor reflex in the mechanism of ANP-induced hypotension.
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
authors.forename: S A
authors.initials: SA
authors.lastname: Davydova
authors.forename: T V
authors.initials: TV
authors.lastname: Stepanova
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
chemical_list: D009320:Atrial Natriuretic Factor
vernacular_title: Baroreflektornyĭ komponent v mekhanizme gipotenzivnogo deĭstviia predserdnykh peptidov.