The role of the mesolimbic dopaminergic system in the desipramine effect in the forced swimming test.
The effects of sulpiride isomers injected into the nucleus accumbens on the anti-immobility activity of desipramine in rats were studied to clarify the role of dopamine receptors. (-)-Sulpiride 100 ng/0.5 microliters injected bilaterally into the nucleus accumbens 5 min before testing reduced the effect of a 7-day treatment with 10 mg/kg per day desipramine in the swimming test but 5 micrograms/0.5 microliter (+)-sulpiride injected in the same area had no effect. Fluphenazine, 5 micrograms/0.5 microliter, or 6-hydroxydopamine-induced depletion of dopamine in the nucleus accumbens also reduced the anti-immobility effect of desipramine. The data further support the hypothesis that dopamine transmission in the nucleus accumbens has a permissive role in the effect of desipramine in the forced swimming test.
Cervo
L
L
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Grignaschi
G
G
Samanin
R
R
D000818:Animals; D003863:Depression / Q000503:physiopathology*; D003891:Desipramine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D005476:Fluphenazine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007267:Injections; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology; D013550:Swimming; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D013469:Sulpiride; D016627:Oxidopamine; D005476:Fluphenazine; D003891:Desipramine; D004298:Dopamine