[The effect of adrenergic agents on the level of extracellular potassium normally and in myocardial ischemia (infarct)].
Adrenergic drugs exert effects on the processes of potassium ions transmembrane distribution between the intra- and extracellular spaces. Drug-induced hypokalemia is the result of beta (predominantly beta-2) adrenergic stimulation. Arrhythmias in myocardial ischemia occur at the combination of hypercatecholaminemia and rapid transmembrane distribution of potassium ions between the intra- and extracellular spaces. The distribution results in the association of the increased local extracellular potassium concentration in the myocardium and rapidly developing hypokalemia.
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D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D013566:Sympathomimetics / Q000494:pharmacology* / Q000627:therapeutic use
D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D011188:Potassium
Vliianie adrenergicheskikh sredstv na uroven' vnekletochnogo kaliia v norme i pri ishemii (infarkte) miokarda.