In vivo hyperthermia induces expression of HSP70 mRNA in brain regions controlling the neuroendocrine response to stress.
Regional localization of HSP70 expression in brain of rats exposed to increased ambient temperatures was examined using in situ hybridization. In addition to the cerebellar granule cell layer and choroid plexus, selective hybridization was observed in the hippocampal dentate gyrus, paraventricular and dorsomedial hypothalamic nuclei, median eminence, and medial habenula. Apparently, cells in brain regions coordinating the neuroendocrine response to stress show a preferential induction of cellular stress proteins in response to heat.
Blake
M J
MJ
Laboratory of Molecular Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.
Nowak
T S
TS
Holbrook
N J
NJ
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006358:Hot Temperature; D008297:Male; D009490:Neurosecretory Systems / Q000503:physiopathology*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism*
D006360:Heat-Shock Proteins; D012333:RNA, Messenger