[Comparative analysis of quinolinic acid and L-kynurenine action on the electrically controlled membrane ion channels of mollusk neurons].
Extrasynaptic effects of kynurenines (chynoline acid and L-kynurenin) on the membrane electrosensitive ionic channels were studied in experiments using isolated somata from the c. n. s. of mollusc Lymnaea stagnalis. The kynurenines either blocked or induced biphasic dose-dependent effect on amplitudes of the membrane ionic currents.
Artem'ev
I Iu
IIu
D000818:Animals; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004594:Electrophysiology; D066298:In Vitro Techniques; D007737:Kynurenine / Q000494:pharmacology*; D008195:Lymnaea / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D015221:Potassium Channels; D011805:Quinolinic Acids; D016194:Receptors, N-Methyl-D-Aspartate; D007737:Kynurenine; D017378:Quinolinic Acid
Sravnitel'nyĭ analiz deĭstviia khinolinovoĭ kisloty i L-kinurenina na élektroupravliaemye ionnye kanaly membrany neĭronov molliuska.