title: Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis.
abstract: We assessed 33 lymphoid tissues from 15 patients, including 7 with X-linked lymphoproliferative disease (XLP) and 8 patients with sporadic fatal infectious mononucleosis (IM), to determine whether the cellular infiltrate had the immunophenotype and expressed Epstein-Barr virus (EBV)-encoded proteins characteristic of either EBV-immortalized lymphoblastoid cell lines (LCL) or EBV-carrying Burkitt lymphoma (BL) cells. The results of these studies revealed that in 13 cases the proliferating B cells were polyclonal, LCL-like, and in 2 cases they were monoclonal, malignant lymphoma-like.
authors.affiliation: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Falk
authors.forename: I
authors.initials: I
authors.lastname: Ernberg
authors.forename: R
authors.initials: R
authors.lastname: Sakthivel
authors.forename: J
authors.initials: J
authors.lastname: Davis
authors.forename: B
authors.initials: B
authors.lastname: Christensson
authors.forename: J
authors.initials: J
authors.lastname: Luka
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: H L
authors.initials: HL
authors.lastname: Grierson
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: D T
authors.initials: DT
authors.lastname: Purtilo
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology* / Q000382:microbiology; D015139:Blotting, Southern; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D016130:Immunophenotyping; D007223:Infant; D007244:Infectious Mononucleosis / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D014764:Viral Proteins / Q000096:biosynthesis*
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins