Experimental congenital cytomegalovirus labyrinthitis and sensorineural hearing loss.
Cytomegalovirus is a leading cause of human congenital viral infection and hearing loss. The pathogenesis of human congenital cytomegalovirus infection is poorly understood. We have developed a reproducible model of congenital cytomegalovirus-induced sensorineural hearing loss in guinea pigs. This report reviews our previously published results and provides additional new information about this model.
Woolf
N K
NK
Department of Surgery, University of California Medical Center, San Diego 92161.
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000302:isolation & purification; D003055:Cochlear Microphonic Potentials; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology; D005072:Evoked Potentials, Auditory; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000503:physiopathology; D007762:Labyrinthitis / Q000209:etiology*
D000956:Antigens, Viral