title: Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase.
abstract: Insight into the regulation of the actions of the protein-tyrosine kinases will be greatly facilitated by the full characterization of the family of protein-tyrosine phosphatases. A search for novel phosphatases resulted in the isolation of a cDNA, termed HLPR, encoding a member of the family of human receptor-like protein-tyrosine phosphatases: its cDNA sequence predicts a protein of 793 amino acids (unglycosylated Mr 87,500) and includes a 121 residue extracellular domain, a single transmembrane segment, and and two tandem intra-cytoplasmic catalytic domains. The HLPR genes is located on human chromosome 20, and the protein it encodes likely plays a fundamental role in the physiology of all cells as its expression appears to be ubiquitous.
authors.affiliation: Biomedical Research Center, University of British Columbia, Vancouver, Canada.
authors.forename: F R
authors.initials: FR
authors.lastname: Jirik
authors.forename: N M
authors.initials: NM
authors.lastname: Janzen
authors.forename: I G
authors.initials: IG
authors.lastname: Melhado
authors.forename: K W
authors.initials: KW
authors.lastname: Harder
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics; D015723:Gene Library; D006801:Humans; D008113:Liver Neoplasms; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004273:DNA, Neoplasm; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases