[Effect of sodium diethyldithiocarbamate on embryogenesis in mice].
Sensitivity of mouse embryos (8-11 days old) to sodium diethyldithiocarbamate (SDDC), inhibitor of dopamine -beta-hydroxylase, has been investigated. SDDC produces certain anomalies in development of the CNS, facial skull, mandible , extremities and others. It is possible that the base of the mechanism, stimulating development of these anomalies, together with the other causes, can be some disturbances in catecholamine metabolism. This, in its turn, can result in disorders of cell interactions via neurotransmitters during active morphogenetic processes.
Khozhaĭ
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Puchkov
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D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004050:Ditiocarb / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011247:Pregnancy
D004050:Ditiocarb
Vliianie diétilditiokarbamata natriia na émbriogenez myshi.