[Combination of adoptive immunotherapy and chemotherapy against advanced cancer with peritoneal dissemination].
In a case of advanced gastric cancer with bilateral Krukenberg's tumors and peritonitis carcinomatosa, total gastrectomy, splenectomy and bilateral oophorectomy was performed. Since progressive peritoneal dissemination was recognized, 150 mg of CDDP and 10 mg of MMC which were proved to be effective by chemosensitivity test of anticancer drugs were administered intraperitoneally. After one month, ascites increased. So LAK cells and TIL were transferred intraperitoneally 6 times. With this treatment ascitic collection remarkably decreased, the performance status improved and serum level of IAP and CA125 normalized. Thus, it is clarified that the combination of adoptive immunotherapy and chemotherapy possesses therapeutic efficacy against advanced gastric cancer with peritonitis carcinomatosa.
Iwahashi
M
M
Department of Gastroenterological Surgery, Wakayama Medical College.
Tanimura
H
H
Yamaue
H
H
Tsunoda
T
T
Tani
M
M
Tamai
M
M
Taniguchi
K
K
Aoki
Y
Y
D002288:Adenocarcinoma, Mucinous / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D007725:Krukenberg Tumor / Q000628:therapy; D016246:Lymphocytes, Tumor-Infiltrating / Q000637:transplantation*; D008937:Mitomycins / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary / Q000628:therapy; D010051:Ovarian Neoplasms / Q000628:therapy; D010534:Peritoneal Neoplasms / Q000628:therapy*; D013274:Stomach Neoplasms / Q000628:therapy*
D007376:Interleukin-2; D008937:Mitomycins; D002945:Cisplatin