[The collagenolytic and general proteolytic activity in synovial fluid cells in rheumatoid arthritis].
The authors made a comparative study of collagenolytic (CA) and neutral caseinolytic activity (NCA) in the cells of the synovial fluid (CSF) depending on the peculiarities of the course of rheumatoid process and also on the duration of the disease prior to and after treatment of rheumatoid arthritis (RA). It has been shown that proteinase is one of the factors of RA pathogenesis. The level of enzymes directly depended on the activity of synovitis. The data obtained show that with a rapidly progressing RA and also with the III degree of the disease activity, CA in CSF were twice as high as those observed with a slowly progressing RA and also with the I-II degree of RA activity. The treatment conducted promoted a rise in CA, NCA in CSF. The possible mechanism of these processes is being discussed.
Solov'eva
N I
NI
Volkova
Z I
ZI
Mul'diiarov
P Ia
PIa
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000473:pathology; D002364:Caseins; D003094:Collagen; D006801:Humans; D003012:Microbial Collagenase / Q000378:metabolism*; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism*; D013582:Synovial Fluid / Q000166:cytology / Q000201:enzymology*
D002364:Caseins; D003094:Collagen; D010447:Peptide Hydrolases; D003012:Microbial Collagenase
Issledovanie kollagenoliticheskoĭ i obshcheĭ proteoliticheskoĭ aktivnosti v kletkakh sinoval'noĭ zhidkosti pri revmatoidnom artrite.