title: [Efficacy of concentrated CDDP-lipiodol emulsion for hepatic arterial infusion therapy in patients with nonresectable hepatoma].
abstract: The efficacy of concentrated CDDP-Lipiodol Emulsion was experimentally and clinically studied in the treatment of nonresectable hepatoma. The commercially available CDDP was ten-fold concentrated into water in oil form. The agent was administered via hepatic artery in 26 patients with nonresectable hepatocellular carcinoma. In vitro and clinical studies strongly suggested a gradual release of the CDDP into the surrounding tissue. In 9 out of 26 patients (34.6%), tumor regression was found. Side effects were minimum; mild nausea and vomiting were observed in only 13 patients. On the basis of our preliminary study, concentrated CDDP-Lipiodol emulsion promises to be a useful agent for the treatment of nonresectable hepatocellular carcinoma.
authors.affiliation: First Dept. of Surgery, Medical College of Oita.
authors.forename: K
authors.initials: K
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Iwao
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Tada
authors.forename: Y I
authors.initials: YI
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: F
authors.initials: F
authors.lastname: Takayama
authors.forename: M
authors.initials: M
authors.lastname: Takeyama
authors.forename: H
authors.initials: H
authors.lastname: Aikawa
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004655:Emulsions; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011379:Prognosis
chemical_list: D003692:Delayed-Action Preparations; D004655:Emulsions; D007459:Iodized Oil; D002945:Cisplatin