title: Myelodysplastic syndrome presenting with generalized cutaneous granulocytic sarcomas.
abstract: A patient with myelodysplastic syndrome (refractory anemia with excess of blasts in transformation, RAEB-T) presented with generalized granulocytic sarcomas involving the skin. The diagnosis was confirmed by skin and bone marrow biopsies. Partial myeloperoxidase deficiency was noted in the circulating polymorphonuclear leukocytes and the more differentiated tumor cells in the granulocytic sarcoma. This observation suggests that such leukocytes may be derived from the abnormal 'leukemic' clone.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital.
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: R
authors.initials: R
authors.lastname: Liang
authors.forename: L
authors.initials: L
authors.lastname: Ma
authors.forename: P W
authors.initials: PW
authors.lastname: Tse
authors.forename: G T
authors.initials: GT
authors.lastname: Chan
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000172:deficiency; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology
chemical_list: D009195:Peroxidase