title: Fusidic acid in staphylococcal bone and joint infection.
abstract: Over 25 years experience with fusidic acid in the treatment of bone and joint infections is reviewed. Fusidic acid, usually given concurrently with another antibiotic, has proved effective in a wide variety of staphylococcal infections, including acute osteomyelitis and septic arthritis. It is a valuable adjunct to surgery in patients with chronic osteomyelitis. Oral therapy is generally well tolerated, apart from gastrointestinal side effects in a small proportion of cases. Use of fusidic acid in other orthopaedic situations is considered in the light of recent information.
authors.affiliation: Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: R R
authors.initials: RR
authors.lastname: Coombs
mesh_terms: D001847:Bone Diseases / Q000188:drug therapy* / Q000382:microbiology; D005672:Fusidic Acid / Q000627:therapeutic use*; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D005672:Fusidic Acid