title: T cell receptor beta-chain gene rearrangement without gamma-chain gene rearrangement in cutaneous T cell lymphoma: an unusual finding.
abstract: T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor beta-chain gene in the absence of rearrangement of the gamma-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor 48109.
authors.forename: V C
authors.initials: VC
authors.lastname: Ho
authors.forename: E R
authors.initials: ER
authors.lastname: Hansen
authors.forename: J T
authors.initials: JT
authors.lastname: Elder
authors.forename: O
authors.initials: O
authors.lastname: Baadsgaard
authors.forename: G L
authors.initials: GL
authors.lastname: Vejlsgaard
authors.forename: C A
authors.initials: CA
authors.lastname: Hanson
authors.forename: K D
authors.initials: KD
authors.lastname: Cooper
mesh_terms: D000368:Aged; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics*; D013601:T-Lymphocytes