Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam.
Alterations in a low affinity form of the GABAA receptor were examined with [3H]bicuculline methylchloride in the adult rat following perinatal exposure to diazepam. Perinatal exposure resulted in a significant reduction in [3H]bicuculline binding in the cingulate cortex. A significant decrease in the ability of GABA to displace bound [3H]bicuculline was observed only in the hypothalamus. The results suggest that the effects of perinatal exposure to diazepam are regionally specific and that benzodiazepine receptors and low affinity GABAA receptors are functionally linked during the perinatal period.
Gruen
R J
RJ
Department of Psychology, New York University, New York 10003.
Elsworth
J D
JD
Roth
R H
RH
D000818:Animals; D001640:Bicuculline / Q000378:metabolism*; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D001640:Bicuculline