title: Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes.
abstract: The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch-clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between -50 and +30 mV. The forskolin-induced increase of INa was mimicked by 1,9-dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.
authors.affiliation: Laboratoire de Physiologie des Eléments Excitables (U.A. CNRS no. 180), Université Claude Bernard, Villeurbanne, France.
authors.forename: R
authors.initials: R
authors.lastname: Bonvallet
authors.forename: F
authors.initials: F
authors.lastname: Lemtiri-Chlieh
authors.forename: O
authors.initials: O
authors.lastname: Rougier
mesh_terms: D000818:Animals; D005576:Colforsin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011893:Rana esculenta; D015222:Sodium Channels / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D015222:Sodium Channels; D005576:Colforsin; D013779:Tetrodotoxin; D007545:Isoproterenol; C047983:1,9-dideoxyforskolin