title: Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors.
abstract: Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal constriction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with beta-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal kappa-opioid receptors.
authors.affiliation: Department of Basic Sciences, Marquette University School of Dentistry, Milwaukee, WI 53233.
authors.forename: R M
authors.initials: RM
authors.lastname: Quock
authors.forename: J A
authors.initials: JA
authors.lastname: Best
authors.forename: D C
authors.initials: DC
authors.lastname: Chen
authors.forename: L K
authors.initials: LK
authors.lastname: Vaughn
authors.forename: P S
authors.initials: PS
authors.lastname: Portoghese
authors.forename: A E
authors.initials: AE
authors.lastname: Takemori
mesh_terms: D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009609:Nitrous Oxide / Q000494:pharmacology*; D010147:Pain Measurement; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000700:Analgesics; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; C024524:beta-funaltrexamine; D009609:Nitrous Oxide