[Reparation of the hepatocyte plasma membrane using phosphatidylcholine liposomes].
Rat hepatocyte plasmatic membrane damages caused by the administration of tetrachloromethane of heliotrine was investigated. Phospholipid content in plasmatic membranes decreased. Heliotrine caused complete and CCL4 twofold inhibition of Na, K-ATPase. Intraperitoneal administration of egg yolk phosphatidylcholine liposomes had a reparative effect on the damaged membranes consisting in the restoration of phospholipid content and enzyme activities.
Dobrynina
O V
OV
Shatinina
S Z
SZ
Archakov
A I
AI
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D008081:Liposomes; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis
D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; D011763:Pyrrolizidine Alkaloids; D002251:Carbon Tetrachloride; D000254:Sodium-Potassium-Exchanging ATPase; C010178:heliotrine
Reparatsiia plazmaticheskoĭ membrany gepatotsitov s pomoshch'iu fosfatidilkholinovykh liposom.