Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus.
Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.
Kestler
H
H
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.
Kodama
T
T
Ringler
D
D
Marthas
M
M
Pedersen
N
N
Lackner
A
A
Regier
D
D
Sehgal
P
P
Daniel
M
M
King
N
N
D000163:Acquired Immunodeficiency Syndrome; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008253:Macaca mulatta; D008264:Macrophages / Q000382:microbiology; D009894:Opportunistic Infections / Q000209:etiology; D012192:Retroviridae Infections / Q000150:complications / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D014162:Transfection; D014779:Virus Replication
D000914:Antibodies, Viral