Chemotaxis of polymorphonuclear leukocytes towards LTB4 in patients with psoriasis in vitro.
The random migration and chemotaxis of polymorphonuclear leukocytes (PMN) in agarose were studied in 21 patients with psoriasis and 10 healthy controls. Different concentrations of LTB4 were used as chemoattractants. The random migration and chemotaxis towards lower concentrations of LTB4 were enhanced and that towards higher concentrations of LTB4 reduced in psoriasis. The differences of body involvement, sex, and family history of psoriasis had no influence on PMN migration.
Sun
R Z
RZ
Department of Dermatology, Changhai Hospital, Second Military Medical College.
Zhou
D Y
DY
Zheng
M R
MR
Yue
T L
TL
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils; D011565:Psoriasis / Q000097:blood*
D007975:Leukotriene B4