title: Determinants of coronavirus MHV pathogenesis are localized to 3' portions of the genome as determined by ribonucleic acid-ribonucleic acid recombination.
abstract: Recombinant viruses derived from coronaviruses mouse hepatitis virus strains JHM and A59, were used to map biologic properties of the virus to viral genes. The 3' portion (about 25%) of the viral genome, including the genes coding for all of the structural proteins, controls biologic properties such as organ tropism of the virus, pattern of the virus-induced central nervous system pathology in mice, plaque morphology, and virus yield in tissue culture.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104.
authors.forename: E
authors.initials: E
authors.lastname: Lavi
authors.forename: E M
authors.initials: EM
authors.lastname: Murray
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: S A
authors.initials: SA
authors.lastname: Stohlman
authors.forename: M M
authors.initials: MM
authors.lastname: Lai
authors.forename: S R
authors.initials: SR
authors.lastname: Weiss
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000382:microbiology / Q000473:pathology; D005814:Genes, Viral; D006524:Hepatitis, Viral, Animal / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000235:genetics / Q000472:pathogenicity*; D009928:Organ Specificity; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014774:Virulence / Q000235:genetics; D014776:Virus Cultivation
chemical_list: D012367:RNA, Viral