Imipramine prevents gastric lesions induced by centrally administered thyrotropin-releasing hormone (TRH) in rats.
Increasing evidence indicates that thyrotropin-releasing hormone (TRH), and endogenous brain-gut peptide may play a role in experimental ulcerogenesis. Potential interactions between TRH and imipramine (a typical tricyclic antidepressant (TCA] on the development of TRH-induced gastric lesions have not been investigated. Imipramine (0.05, 0.5 and 5 mg/kg, i.p.) dose-dependently inhibited gastric lesion formation induced by intracisternal (i.c.) administration of TRH (1 micrograms). In addition, imipramine (5 mg/kg, i.p.) significantly decreased gastric acid secretion in response to i.c. TRH (1 microgram) in rats with pyloric ligation. These findings suggest the TCAs may be effective drug agents against centrally initiated gastric ulcerations. The mechanism of this response probably involves blockade of cholinergic (muscarinic) and H2 histamine receptors.
Hernandez
D E
DE
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Arredondo
M E
ME
Xue
B G
BG
D000818:Animals; D001921:Brain / Q000187:drug effects; D002712:Chlorides / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008094:Lithium / Q000008:administration & dosage; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage
D002712:Chlorides; D013973:Thyrotropin-Releasing Hormone; D008094:Lithium; D018021:Lithium Chloride; D007099:Imipramine