[Isolation of a Staphylococcus aureus strain resistant to pefloxacin after treatment with pefloxacin and gentamycin].
A mutant of Staphylococcus aureus resistant to pefloxacin was selected after combination therapy using pefloxacin and gentamicin. This phenomenon is probably due to impaired diffusion of gentamicin into the paravertebral abscess. This led to a monotherapy, in situ, unable to prevent the selection of mutant.
Chomarat
M
M
Laboratoire de Bactériologie, Centre Hospitalier Lyon-Sud, Pierre-Bénité.
Gerbaud
G
G
Vital-Durand
D
D
D004352:Drug Resistance, Microbial / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015366:Pefloxacin / Q000494:pharmacology*; D010403:Penicillin Resistance; D015363:Quinolones / Q000494:pharmacology; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*
D005839:Gentamicins; D015363:Quinolones; D015366:Pefloxacin
Sélection d'un mutant de Staphylococcus aureus résistant à la péfloxacine sous traitement antibiotique associant péfloxacine et gentamicine.