title: Estimation of cerebral blood flow during cardiopulmonary resuscitation in humans.
abstract: Cerebral blood flow (CBF) and cardiac output (CO) were measured during cardiopulmonary resuscitation in patients who were unsuccessfully resuscitated by use of C14-iodoantipyrine injected into the left ventricle. CO varied between 1.3 and 2.2 l/min with mean 1.8 +/- 0.6 l/min (+/- SD) (28 ml/kg/min). The cortical CBF was found between 14 and 211 ml 100 g-1.min-1 with mean 42 ml 100 g-1.min-1 and mean white matter CBF equal to 27 ml 100 g-1.min-1. It is suggested that the external cardiac massage in humans may be of poor efficacy in terms of brain revival. Cortical CBF after long-lasting cardiopulmonary resuscitation showed signs of maldistribution suggestive of a patchy and incomplete perfusion.
authors.affiliation: Hvidovre University Hospital, Denmark.
authors.forename: S F
authors.initials: SF
authors.lastname: Christensen
authors.forename: C
authors.initials: C
authors.lastname: Stadeager
authors.forename: E
authors.initials: E
authors.lastname: Siemkowicz
mesh_terms: D000368:Aged; D000983:Antipyrine / Q000031:analogs & derivatives; D001784:Blood Gas Analysis; D002250:Carbon Radioisotopes; D002302:Cardiac Output / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004554:Electric Countershock; D005260:Female; D006336:Heart Massage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation
chemical_list: D002250:Carbon Radioisotopes; D000983:Antipyrine; C008135:iodoantipyrine