title: Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies.
abstract: Proton magnetic resonance spectroscopy (1H MRS) was used to investigate intracranial tumours in vitro and in vivo. Biopsy specimens were studied from 47 patients, 11 of whom were also examined in vivo. Analysis was based on the signals from N-acetylaspartate (NAA), phosphocreatine plus creatine (Cr), choline-containing compounds (Cho), alanine (Ala), and lactate. Biopsy data from 26 astrocytomas showed that the NAA/Cr ratio differs significantly in all grades from its value in normal white matter and that the Cho/Cr ratio differs significantly in grade IV tumours from its value in the other grades. Meningiomas have an unusually high Ala/Cr ratio. Spectra obtained in vivo are consistent with in vitro results from the same patients, and their lactate signal provides additional information about abnormal metabolism. We conclude that 1H MRS has a clear role in the diagnosis and biochemical assessment of intracranial tumours and in the evaluation and monitoring of therapy.
authors.affiliation: Neurosurgery Department, National Hospitals for Nervous Diseases, London, England.
authors.forename: S S
authors.initials: SS
authors.lastname: Gill
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: Van Bruggen
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: C J
authors.initials: CJ
authors.lastname: Peden
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: I J
authors.initials: IJ
authors.lastname: Cox
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
authors.forename: R A
authors.initials: RA
authors.lastname: Iles
authors.forename: D J
authors.initials: DJ
authors.lastname: Bryant
mesh_terms: D000328:Adult; D000368:Aged; D000409:Alanine / Q000032:analysis; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001254:Astrocytoma / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008579:Meningioma / Q000175:diagnosis*; D008875:Middle Aged; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D007773:Lactates; D010725:Phosphocreatine; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline; D000409:Alanine