title: Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae.
abstract: 6-Cyano-5-methoxy-12-methylindolo[2,3-alpha]carbazole and 6-cyano-5-methoxyindolo[2,3-alpha]carbazole are responsible for most of the cytotoxicity and antiviral activity associated with the blue-green alga Nostoc sphaericum EX-5-1. The compounds are active against HSV II and show weak cytotoxicity against KB and LoVo human carcinoma cell lines.
authors.affiliation: Department of Chemistry, University of Hawaii, Honolulu 96822.
authors.forename: G
authors.initials: G
authors.lastname: Knübel
authors.forename: L K
authors.initials: LK
authors.lastname: Larsen
authors.forename: R E
authors.initials: RE
authors.lastname: Moore
authors.forename: I A
authors.initials: IA
authors.lastname: Levine
authors.forename: G M
authors.initials: GM
authors.lastname: Patterson
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D000458:Cyanobacteria / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018139:Simplexvirus / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D002227:Carbazoles; D003603:Cytotoxins; D007211:Indoles; C066545:6-cyano-5-methoxy-12-methylindolo(2,3-a)carbazole; C066546:6-cyano-5-methoxyindolo(2,3-a)carbazole