title: Dissociation between uric acid and urea clearances in the syndrome of inappropriate secretion of antidiuretic hormone related to salt excretion.
abstract: 1. Our purpose was to determine why hypouricaemia is more frequently observed than hypouraemia in the syndrome of inappropriate secretion of antidiuretic hormone. We have retrospectively analysed the scores of 35 patients with a chronic form of hyponatraemia related to the syndrome of inappropriate secretion of antidiuretic hormone and studied prospectively six patients. 2. The patients with high fractional excretion of filtered urea (greater than 55%) presented lower blood urea and lower salt excretion than the patients with normal fractional excretion of filtered urea, despite similar levels of hyponatraemia and of osmotic and uric acid clearances. In six hyponatraemic patients, an increase in salt intake was accompanied by a decrease in fractional excretion of filtered urea. In the syndrome of inappropriate secretion of antidiuretic hormone, the fractional excretion of filtered urea was inversely correlated to the fractional excretion of filtered sodium (r = -0.66; P less than 0.001), whereas the fractional excretion of filtered uric acid was not dependent on sodium excretion. 3. Hypouraemia with high fractional excretion of filtered urea in patients with the syndrome of inappropriate secretion of antidiuretic hormone is related to low urinary sodium excretion and thus reflects low sodium intake.
authors.affiliation: Department of Internal Medicine, School of Medicine, Free University of Brussels, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Decaux
authors.forename: F
authors.initials: F
authors.lastname: Prospert
authors.forename: P
authors.initials: P
authors.lastname: Cauchie
authors.forename: A
authors.initials: A
authors.lastname: Soupart
mesh_terms: D000328:Adult; D006801:Humans; D007010:Hyponatremia / Q000378:metabolism; D007177:Inappropriate ADH Syndrome / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D012189:Retrospective Studies; D012964:Sodium / Q000652:urine*; D012982:Sodium, Dietary / Q000378:metabolism; D014508:Urea / Q000097:blood / Q000652:urine*; D014527:Uric Acid / Q000652:urine*
chemical_list: D012982:Sodium, Dietary; D014527:Uric Acid; D014508:Urea; D012964:Sodium