[Increase of noradrenaline contents in the hypothalamus of neonatal female rats under the effects of 4-hydroxyestradiol-17beta].
Catecholamine content was studied in hypothalamus of neonatal Wistar female rats treated with 4-hydroxyestradiol-17 (4-OH-E2) in a dose of 10 mg for 1-5 days of life. 4-OH-E2 induced a reliable increase in hypothalamic noradrenaline level in 24 h after the last injection, but not on the 7th, 10th or 12th postnatal days. There was no change in dopamine level. We have postulated a relationship between the increase in hypothalamic noradrenaline content induced by 4-OH-E2 and defeminization effects of 4-OH-E2 on the developing brain of female rats.
Nosenko
N D
ND
Reznikov
A G
AG
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002393:Estrogens, Catechol / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D002393:Estrogens, Catechol; D004958:Estradiol; C014036:4-hydroxyestradiol; D009638:Norepinephrine
Povyshenie soderzhaniia noradrenalina v gipotalamuse novorozhdennykh krys-samok pod vozdeĭstviem 4-gidroksiéstradiola-17beta.