Accumulation of each element in the lysosome of tumor and liver cells as systematized according to its location in the periodic table.
Hard and borderline acids which were formed by losing electrons from the d-shell accumulated extensively in the lysosomes of tumor and liver with time after administration of these ions. They were bound in these tissues to acid mucopolysaccharides, the mol. wt of which exceed 40,000 Da. Trivalent hard acids which were formed by losing electrons from s- or p-shells accumulated extensively in liver lysosomes, but very little in tumor lysosomes, and were bound in the tissues to the acid mucopolysaccharides with a mol. wt of ca 10,000 Da.
Ando
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School of Allied Medical Professions, Kanazawa University, Japan.
Ando
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D000818:Animals; D008099:Liver / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D008297:Male; D008670:Metals / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009368:Neoplasm Transplantation; D051381:Rats; D012517:Sarcoma, Yoshida / Q000378:metabolism*
D008670:Metals