Alterations in Na+, K+ and Ca2+ transport in erythrocytes of patients with carcinomas of the head and neck: possible role of mild anaemia and cell age.
1. Rates of erythrocyte Ca2+ inward transport, activities of erythrocyte Ca2(+)-adenosine triphosphatase, Na+, K+ pump, Na(+)-K+ co-transport and Na(+)-Li+ exchange, and erythrocyte Ca2+, K+ and Na+ contents have been determined in patients with carcinomas of the head and neck. 2. Decreases in Ca2+ inward transport and Na(+)-K+ co-transport activity, and increases in erythrocyte Ca2+ and K+ contents, were observed. 3. The more pronounced changes found in advanced carcinoma stages proved to be related to a 50% incidence of a mild anaemia of chronic disease in patients with carcinoma stages T3 and T4. 4. 'Young' (light) erythrocytes from healthy donors obtained by density centrifugation showed modifications in Na+ transport and K+ content similar to those seen in the patients. 5. It is concluded that the decrease in Na(+)-K+ co-transport activity, as well as the elevated K+ content and the lowered mean corpuscular haemoglobin content, but not the disturbances in Ca2+ homoeostasis, in erythrocytes of patients with carcinomas of the head and neck are most probably due to the occurrence of a mild anaemia of chronic disease in advanced carcinoma stages, associated with a reduction in mean erythrocyte age.
Engelmann
B
B
Physiologisches Institut der Universität München, F.R.G.
Grevers
G
G
Janka
H U
HU
Duhm
J
J
D000328:Adult; D000740:Anemia / Q000097:blood* / Q000209:etiology; D001693:Biological Transport, Active; D002118:Calcium / Q000097:blood*; D000252:Calcium-Transporting ATPases / Q000097:blood; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D012964:Sodium; D007501:Iron; D000252:Calcium-Transporting ATPases; D011188:Potassium; D002118:Calcium