The affinity ligand "UPHIT" acylates kappa opioid binding sites in vivo.
Band
L
L
Laboratory of Clinical Science, NIMH, Bethesda, MD 20892.
de Costa
B R
BR
Bykov
V
V
Pert
A
A
Rice
K C
KC
Rothman
R B
RB
D000215:Acylation; D000818:Animals; D044482:Benzeneacetamides; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D003510:Cyclohexanes / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D011759:Pyrrolidines / Q000378:metabolism*; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
D044482:Benzeneacetamides; D003510:Cyclohexanes; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; C063077:2-isothiocyanato-4,5-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)benzeneacetamide