[Treatment of carcinomatous effusion with oily anticancer agents dissolved in lipiodol].
The oily anticancer agents dissolved in lipiodol used for arterial administration against various solid tumors in our department were found to be applicable to treat for pleural or peritoneal carcinomatosis experimentally and clinically. The pharmacokinetic study with rat model showed oily anticancer agents were retained in a high concentration in the peritoneal cavity compared to water-soluble anticancer agents. In our pilot clinical study all patients with pleural or peritoneal carcinomatosis showed improvement cytologically and physically.
Kimura
M
M
First Dept. of Surgery, Kumamoto University Medical School.
Konno
T
T
Oda
T
T
Yamashita
R
R
D000328:Adult; D000368:Aged; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001202:Ascitic Fluid / Q000188:drug therapy*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D008297:Male; D008299:Maleic Anhydrides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008875:Middle Aged; D010996:Pleural Effusion / Q000188:drug therapy*; D011137:Polystyrenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D009353:Zinostatin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000493:pharmacokinetics
D000903:Antibiotics, Antineoplastic; D005663:Furans; D008299:Maleic Anhydrides; D011137:Polystyrenes; C035755:poly(maleic acid-styrene)neocarzinostatin; D007459:Iodized Oil; D004317:Doxorubicin; D009353:Zinostatin