title: [Safety aspects of the practical application of a gI-negative subunit vaccine against Aujeszky's disease in swine].
abstract: On two farms in an area in which Aujeszky's disease is endemic, 192 pregnant sows were vaccinated with a gI-negative sub-unit vaccine against Aujeszky's disease. The rectal temperatures of the sows were recorded once daily for seven consecutive days, starting on the day of vaccination, and the vaccinated animals were observed for local and systemic reactions. The temperatures recorded did not exceed 39.8 degrees C in any case, and local or systemic reactions caused by vaccinations were not observed. One sow (0.6 per cent) aborted, but other symptoms of disease were not apparent, and there was no relationship with vaccination. In a second experiment, the carcasses of 120 pigs, vaccinated once or twice with the same vaccine, were carefully examined for local reactions. In eleven pigs (9.1 per cent) slight cicatricial reactions were visible within from 20 to 34 days after inoculation, the diameter not exceeding 1.5 cm in any of the cases. Traces of vaccination were no longer perceptible within 84 days after vaccination. The vaccine was found to be very safe for pregnant sows under field conditions.
authors.forename: H B
authors.initials: HB
authors.lastname: van Lom
authors.forename: R S
authors.initials: RS
authors.lastname: Schrijver
authors.forename: G
authors.initials: G
authors.lastname: Reynaud
authors.forename: C
authors.initials: C
authors.lastname: Schirvel
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D011557:Pseudorabies / Q000517:prevention & control*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014765:Viral Vaccines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014765:Viral Vaccines
vernacular_title: Veiligheidsaspecten van toepassing van een gI-negatief sub-unitvaccin tegen de ziekte van Aujeszky bij varkens in de praktijk.