[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
The linear cerebral blood flow (LCBF) was explored in 75 patients with epilepsy according to 131I-albumin transition. LCBF acceleration on the side of the focus, during which the attacks occur rarely and the background EEG remains unchanged is regarded as the most adequate LCBF. The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus. The pattern of LCBF alterations depends as well on the form of epilepsy. Subclinical activation of the epileptic focus by corasole or hyperventilation gives rise to an increase of the LCBF on its side in patients with generalized secondary epilepsy, to a lowering in temporal epilepsy, and the lack of dynamics in the precentral disease pattern. Correction of the hemodynamic disorders can be attained with the aid of combining phenobarbital and caffeine or papaverine. The pathogenetic importance of the hemodynamic disorders is discussed in connection with functional hypoxia of neurons.
Shutov
A A
AA
Shestakov
V V
VV
D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000188:drug therapy / Q000209:etiology*; D002110:Caffeine / Q000008:administration & dosage; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage; D010634:Phenobarbital / Q000008:administration & dosage; D012039:Regional Blood Flow / Q000187:drug effects
D002110:Caffeine; D010208:Papaverine; D010634:Phenobarbital
Izmeneniia tserebral'noĭ gemotsirkuliatsii i ikh korrektsiia v mezhparoksizmal'nom periode épilepsii.