[The dynamics of the T-lymphocyte subpopulations and the peroxidase activity of the neutrophils in children immunized with a live mumps vaccine].
The amount of T-helpers and T-suppressors and the T-helper/T-suppressor ratio were determined in 30 practically healthy children aged 1.5-2 years, immunized with live parotitis vaccine prepared from strain -3. One immunization dose of the vaccine contained 7,950 HADU50. In all children peroxidase activity in the cytoplasm of neutrophils was studied. This investigation revealed that in all examined children the formation of immune response to immunization with live parotitis vaccine was accompanied by the development of an imbalance of immunoregulatory T-cell subpopulations and by functional changes in neutrophils, characterized by the inhibition of peroxidase activity. The changes revealed in this study were most pronounced in children with a high level of antibody formation.
Zakharova
T R
TR
Bolotovskiĭ
V M
VM
Titova
N S
NS
Gelikman
B G
BG
D000914:Antibodies, Viral / Q000097:blood; D006801:Humans; D007114:Immunization; D007223:Infant; D007958:Leukocyte Count; D009107:Mumps / Q000276:immunology / Q000517:prevention & control; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D009504:Neutrophils / Q000201:enzymology*; D009195:Peroxidase / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D009108:Mumps Vaccine; D009195:Peroxidase
Dinamika subpopuliatsiĭ T-limfotsitov i aktivnost' peroksidazy neĭtrofilov u deteĭ, immunizirovannykh zhivoĭ parotitnoĭ vaktsinoĭ.