Powerful anti-sperm motility action of cobaltous ion and its recovery by a sulfhydryl compound.
Cobaltous ion, at extremely low concentrations, exercises powerful sperm-immobilizing properties, which could be recovered by a sulfhydryl compound, cysteine. The loss of sperm surface thiol groups and the augmented production of superoxide anion radicals are observed, which could explain the loss of motility of human spermatozoa in vitro as a consequence of cobalt treatment.
Kumar
G P
GP
School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, M.P., India.
Laloraya
M
M
Laloraya
M M
MM
D003035:Cobalt / Q000494:pharmacology*; D003545:Cysteine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D005455:Fluorescent Antibody Technique; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D012661:Semen / Q000032:analysis; D013081:Sperm Motility / Q000187:drug effects*
D003035:Cobalt; C018021:cobaltous chloride; D003545:Cysteine