The effects of 3-deazaguanine on Rous sarcoma virus transformation.
An expression of cellular transformation in chicken embryo fibroblast infected with Rous sarcoma virus (RSV) was inhibited by 3-deazaguanine (3-DG). Re-transformation of normal rat kidney cells infected with a temperature-sensitive mutant of RSV was suppressed by 3-DG when the cells were shifted from the non-permissive temperature (38 degrees C) to the permissive temperature (33 degrees C). Removal of the inhibitor enabled the cells to revert to the transformed state. Finally, 3-DG had little or no effect on replication of RSV in the chicken embryo fibroblast cells.
Chen
Y C
YC
Center for Advanced Medical Technology, San Francisco State University, California.
Liu
L A
LA
Borchardt
K A
KA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects*; D002415:Cats; D002472:Cell Transformation, Viral / Q000187:drug effects*; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013696:Temperature
D000998:Antiviral Agents; D006147:Guanine; C010567:3-deazaguanine