[Histological localization of TAG72 in gastric cancers and a clinico-pathological study of the CA72-4 serum values].
A histochemical localization of TAG72, obtained through a reaction to MoAb CC49 and B72.3 in gastric cancer tissues, demonstrated a negative reaction in normal epithelium and a positive reaction in the cellular membranes of patients with enteric metaplasia and/or a well-differentiated adenocarcinoma, as well as a positive reaction in the cytoplasm in the majority of patients with a gastric adenocarcinoma. A CA72-4 (TAG72) serum assay was conducted on those with a gastric cancer and/or another malignant disease and then compared with other tumor markers. The overall positive rate of CA72-4 in patients with a malignant disease was 33.1% (59/178 cases). A significant elevation was found in cases of a colonic, gastric, and ovarian cancer, 55.0%, 53.3%, 54.5%, respectively.
Konishi
F
F
Dept. of Pathology, Kanazawa Medical Univ.
Matzunou
H
H
Konishi
K
K
Yamamichi
N
N
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D000328:Adult; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D005189:False Positive Reactions; D006023:Glycoproteins / Q000032:analysis* / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D011863:Radioimmunoassay; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C047052:tumor-associated antigen 72