title: Three cases of neonatal herpes simplex virus infection presenting as fulminant hepatitis.
abstract: We report three cases of neonatal herpes simplex virus (HSV) infection presenting as fulminant hepatitis. None of the patients had clear risk factors for HSV infection and they all died. Antiviral treatment for HSV is currently available but must be administered early in the course of the disease before irreversible liver tissue damage is present. Since the diagnosis may be difficult to establish, we wish to draw the attention of clinicians to the presentation of neonatal HSV infection and suggest that in such cases viral cultures, including culture of liver tissue, should be obtained early and antiviral treatment administered while awaiting the culture results.
authors.affiliation: Department of Paediatrics, Hôpital cantonal Universitaire, Geneve, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Benador
authors.forename: W
authors.initials: W
authors.lastname: Mannhardt
authors.forename: D
authors.initials: D
authors.lastname: Schranz
authors.forename: C
authors.initials: C
authors.lastname: Braegger
authors.forename: S
authors.initials: S
authors.lastname: Fanconi
authors.forename: S
authors.initials: S
authors.lastname: Hassam
authors.forename: V
authors.initials: V
authors.lastname: Talebzadeh
authors.forename: J
authors.initials: J
authors.lastname: Cox
authors.forename: S
authors.initials: S
authors.lastname: Suter
mesh_terms: D000208:Acute Disease; D000212:Acyclovir / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006561:Herpes Simplex / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis; D018139:Simplexvirus / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000212:Acyclovir