title: The IgG, IgM, and IgA isotypes of anti-topoisomerase I and anticentromere autoantibodies.
abstract: We studied the expression of IgG, IgM, and IgA autoantibodies in the anti-topoisomerase I and anticentromere immune responses by enzyme-linked immunosorbent assay, immunoblotting, and immunofluorescence. While IgG autoantibodies were most common, IgA autoantibodies were also frequently found, but IgM autoantibodies were rare. This is the first report of IgA autoantibodies in scleroderma.
authors.affiliation: Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.
authors.forename: S
authors.initials: S
authors.lastname: Hildebrandt
authors.forename: E
authors.initials: E
authors.lastname: Weiner
authors.forename: J L
authors.initials: JL
authors.lastname: Senécal
authors.forename: S
authors.initials: S
authors.lastname: Noell
authors.forename: L
authors.initials: L
authors.lastname: Daniels
authors.forename: W C
authors.initials: WC
authors.lastname: Earnshaw
authors.forename: N F
authors.initials: NF
authors.lastname: Rothfield
mesh_terms: D001323:Autoantibodies; D002503:Centromere / Q000276:immunology*; D002875:Chromosomes / Q000276:immunology*; D004264:DNA Topoisomerases, Type I / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D004264:DNA Topoisomerases, Type I