Brattleboro rats have deficient adrenocorticotropin responses to activation of central alpha 1-adrenoceptors.
This experiment was designed to test further the hypothesis that vasopressin is the major mediator of the ACTH response to activation of central alpha 1-adrenoceptors in the rat. The alpha 1-adrenergic agonist methoxamine was given intracerebro-ventricularly to conscious vasopressin-deficient (homozygous Brattleboro) and normal rats bearing venous and intracerebro-ventricular cannulae. Methoxamine stimulated the secretion of ACTH in the normal, but not in the vasopressin-deficient, rats. The data confirm that vasopressin, rather than CRH-41 or oxytocin, is the major hypothalamic peptide that mediates the effects of central alpha 1-adrenoceptors on the pituitary corticotrophs.
al-Damluji
S
S
Department of Endocrinology, Medical College of St. Bartholomew's Hospital, London, United Kingdom.
White
A
A
Besser
M
M
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004327:Drinking Behavior; D007276:Injections, Intraventricular; D008297:Male; D008729:Methoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D051381:Rats; D011910:Rats, Brattleboro; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D013045:Species Specificity; D014667:Vasopressins / Q000172:deficiency / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D014667:Vasopressins; D000324:Adrenocorticotropic Hormone; D008729:Methoxamine