Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide.
Bock
M G
MG
Department of Medicinal Chemistry, Merck, Sharp & Dohme Research Laboratories, West Point, Pennsylvania 198486.
DiPardo
R M
RM
Williams
P D
PD
Pettibone
D J
DJ
Clineschmidt
B V
BV
Ball
R G
RG
Veber
D F
DF
Freidinger
R M
RM
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011945:Receptors, Angiotensin / Q000187:drug effects*; D018045:Receptors, Oxytocin; D013302:Streptomyces; D014599:Uterus / Q000187:drug effects
D009842:Oligopeptides; D010456:Peptides, Cyclic; D011945:Receptors, Angiotensin; D018045:Receptors, Oxytocin; D010121:Oxytocin