Suppression of lymphocyte blastogenesis to mitogens in cats experimentally infected with feline immunodeficiency virus.
Lymphocytes from normal cats or cats experimentally infected with feline immunodeficiency virus (FIV) were stimulated with phytohemagglutinin, pokeweed mitogen, or concanavalin A. Lymphocytes from infected cats had lower responses than those from uninfected cats. These results support the hypothesis that FIV induces immunosuppression.
Lin
D S
DS
Department of Microbiology, Immunology, and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
Bowman
D D
DD
Jacobson
R H
RH
Barr
M C
MC
Fevereiro
M
M
Williams
J R
JR
Noronha
F M
FM
Scott
F W
FW
Avery
R J
RJ
D000818:Animals; D002415:Cats; D002478:Cells, Cultured; D003208:Concanavalin A; D004797:Enzyme-Linked Immunosorbent Assay; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A