title: Unusual features of protein interaction in human immunodeficiency virus (HIV) virions.
abstract: The treatment of HIV-1 virions with ionic and nonionic detergents (NP 40, octylglucoside, Na deoxycholate) resulted in an effect unusual for enveloped viruses: instead of solubilization of glycoproteins, the core protein p24 was solubilized while envelope glycoproteins with other structural proteins were found in subviral particles. These data are consistent with a model of HIV structural organization in which glycoproteins are included in the matrix formed by the protein p 17 and suggest that p24 is neither involved in the matrix nor closely bound to any viral proteins.
authors.affiliation: D. I. Ivanovsky Institute of Virology, U.S.S.R. Academy of Medical Sciences, Moscow.
authors.forename: A G
authors.initials: AG
authors.lastname: Bukrinskaya
authors.forename: N K
authors.initials: NK
authors.lastname: Sharova
mesh_terms: D003902:Detergents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000648:ultrastructure; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D013501:Surface-Active Agents / Q000494:pharmacology*; D014764:Viral Proteins / Q000187:drug effects*; D014771:Virion / Q000187:drug effects
chemical_list: D003902:Detergents; D013501:Surface-Active Agents; D014764:Viral Proteins