[Participation of agonists and antagonist of opiate receptors in the regulation of contractile activity of lymphatic microvessels of the rat mesentery].
The contractile activity of the wall and valve of lymphatic microvessels (LM) of the rat mesentery were studied biomicroscopically by optic photometry. Opioid peptides-Leu-enkephalin and dalargin-stimulated LM. Preliminary application of naloxone on the LM prevented the appearance of the LM contractions following the Leu-enkephalin-application. Naloxone did not inhibit contractions of LM previously activated by Leu-enkephalin. It is supposed that opioid mechanisms are involved in the regulation of the LM contractile activity.
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D000818:Animals; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008643:Mesentery; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology*
D011957:Receptors, Opioid; D013565:Sympatholytics; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Uchastie agonistov i antagonista opiatnykh retseptorov v reguliatsii sokratitel'noĭ aktivnosti limfaticheskikh mikrososudov bryzheĭki kishechnika krysy.