[The effect of 6-hydroxydopamine on the behavior of rats with differing resistance to stress exposure].
The influences of 6-OHDA (150 mcg intraventricular, bilaterally) on the behaviour of Wistar rats with different resistance to sound-stress were studied. Reduction of reactivity, exploratory activity and learning deterioration after 6-OHDA administration were observed. The behavioural disturbances were more demonstrative in stress-resistant rats. Biochemical estimations showed that 6-OHDA induced a reduction of brain noradrenaline level in stress-resistant rats and a reduction of dopamine level in nonresistant animal. It is suggested that more demonstrative behavioural disturbances induced by 6-OHDA in stress-resistant rats are connected with deficit of brain noradrenaline.
Gromova
E A
EA
Semenova
T P
TP
Gasanov
G G
GG
Ismaĭlova
Kh Iu
KhIu
Fast
A E
AE
Nesterova
I V
IV
D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004198:Disease Susceptibility / Q000503:physiopathology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D006892:Hydroxydopamines; D009498:Neurotoxins; D016627:Oxidopamine
Vliianie 6-oksidofamina na povedenie krys s razlichnoĭ ustoĭchivost'iu k stressornym vozdeĭstviiam.