title: Neutralizing antibodies to all seven serotypes of foot-and-mouth disease virus elicited by synthetic peptides.
abstract: Uncoupled peptides from all seven serotypes of foot-and-mouth disease virus (FMDV) protein VP1 have been used to elicit neutralizing antibody responses in guinea-pigs. The responses were largely serotype specific, although some significant cross-neutralization was observed. Dimeric tandem peptides have also been used to simultaneously elicit neutralizing antibodies to two different FMDV serotypes. The possible existence of structural features common to the B-cell neutralization sites or the guinea-pig helper T-cell sites within all seven peptides are analysed and discussed.
authors.affiliation: Department of Virology, Wellcome Biotechnology Ltd, Beckenham, Kent, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Francis
authors.forename: G Z
authors.initials: GZ
authors.lastname: Hastings
authors.forename: B E
authors.initials: BE
authors.lastname: Clarke
authors.forename: A L
authors.initials: AL
authors.lastname: Brown
authors.forename: C R
authors.initials: CR
authors.lastname: Beddell
authors.forename: D J
authors.initials: DJ
authors.lastname: Rowlands
authors.forename: F
authors.initials: F
authors.lastname: Brown
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000918:Antibody Specificity; D005537:Aphthovirus / Q000145:classification / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D012703:Serotyping; D015678:Viral Structural Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D010455:Peptides; D015678:Viral Structural Proteins