title: Investigation of bovine viral diarrhea virus infections in a range beef cattle herd.
abstract: Bovine viral diarrhea virus (BVDV) infections resulting in clinical disease developed in calves, despite vaccination of dams and high maternal BVDV antibody titers in calves. Eight persistently infected (PI) calves born to immunocompetent dams were identified in the herd. Neutralizing BVDV antibody titers of PI calves had decreased greatly by the time the calves were 1 to 2 months old. Antibody titers of PI calves decreased more rapidly than antibody titers of calves that were not PI. Reduced antibody titers in PI calves allowed detection of BVDV in serum specimens of all PI calves by the time they were 8 weeks old. Persistent infection in suspect calves was detectable serologically and was confirmed by virologic examination of serum specimens 4 months after weaning, when the calves were 9 months old. Growth rates were reduced in viremic calves.
authors.affiliation: Department of Veterinary Science, Institute of Agriculture and Natural Resources, University of Nebraska, Lincoln 68583-0905.
authors.forename: C L
authors.initials: CL
authors.lastname: Kelling
authors.forename: L C
authors.initials: LC
authors.lastname: Stine
authors.forename: K K
authors.initials: KK
authors.lastname: Rump
authors.forename: R E
authors.initials: RE
authors.lastname: Parker
authors.forename: J E
authors.initials: JE
authors.lastname: Kennedy
authors.forename: R T
authors.initials: RT
authors.lastname: Stone
authors.forename: G S
authors.initials: GS
authors.lastname: Ross
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D001835:Body Weight; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000175:diagnosis / Q000276:immunology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D007117:Immunization, Secondary / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology; D014766:Viremia / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines