title: Induction of heterotypic virus resistance in adult inbred mice immunized with a variant of Coxsackievirus B3.
abstract: Infection of adult male C3H/HeJ mice with a host range variant of Coxsackievirus B3 (CB3W-RD) induced resistance in these mice to an otherwise lethal dose of Coxsackievirus B1 (CB1). The protective effect induced by CB3W-RD was detectable as early as 1 day post-vaccination and was still present 10 weeks later. While untreated mice infected with CB1 died within 5 days because of massive hepatic necrosis, the liver was spared in mice immunized with CB3W-RD and then challenged with CB1. In general, CB1 titers in heart, liver, and pancreas of CB3W-RD-vaccinated animals were lower than that found in unvaccinated animals. Virus neutralizing antibody was not a mediator of this heterotypic, virus-induced protective effect. In addition, the outcome of CB1 infection could be modified if superinfection with CB3W-RD took place within 1-4 days following CB1 infection. In this regard, maximum therapeutic efficacy was observed when CB1 infected mice were superinfected 2 days after CB1 infection. CB1-infected mice that survived as a result of treatment with CB3W-RD exhibited liver regeneration but did develop myocardial necrosis.
authors.affiliation: Department of Microbiology and Immunology, Hahnemann University School of Medicine, Philadelphia, PA 19102.
authors.forename: B J
authors.initials: BJ
authors.lastname: Landau
authors.forename: P S
authors.initials: PS
authors.lastname: Whittier
authors.forename: S D
authors.initials: SD
authors.lastname: Finkelstein
authors.forename: B
authors.initials: B
authors.lastname: Alstein
authors.forename: J B
authors.initials: JB
authors.lastname: Grun
authors.forename: M
authors.initials: M
authors.lastname: Schultz
authors.forename: R L
authors.initials: RL
authors.lastname: Crowell
mesh_terms: D000818:Animals; D003384:Coxsackievirus Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D029822:Enterovirus B, Human / Q000276:immunology* / Q000302:isolation & purification; D007694:Killer Cells, Natural / Q000276:immunology; D008099:Liver / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009500:Neutralization Tests; D010179:Pancreas / Q000473:pathology; D014611:Vaccination