title: Cyclic AMP as an intracellular messenger of gonadotrophin-induced steroidogenesis during the development of the embryonic chick ovary.
abstract: (1) Ovine luteinizing hormone (LH) stimulates cyclic AMP (cAMP) and progesterone production (P) throughout late ontogeny of the chick ovary and cAMP mimicks LH in stimulating P secretion but: (2) P/cAMP ratios are lower at the earliest stages than at hatching, LH enhancing this tendency. (3) Immediately before hatching, on day 19 time-courses of LH stimulations of cAMP and P are different. (4) cAMP and P respond differently to increasing doses of LH but similarly to increasing doses of forskolin. (5) 1.5 mM dibutyryl cAMP (I) and 100 ng LH (II) increase P maximally, 2.5- and 3.3-fold respectively, but a mixture (I + II) increases P 7.5-fold.
authors.affiliation: Departmento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
authors.forename: C B
authors.initials: CB
authors.lastname: González
authors.forename: M L
authors.initials: ML
authors.lastname: Cantore
authors.forename: C P
authors.initials: CP
authors.lastname: Lantos
authors.forename: S
authors.initials: S
authors.lastname: Passeron
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002642:Chick Embryo; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D011374:Progesterone / Q000096:biosynthesis; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D013256:Steroids / Q000096:biosynthesis*
chemical_list: D013256:Steroids; D005576:Colforsin; D011374:Progesterone; D003994:Bucladesine; D007986:Luteinizing Hormone; D000242:Cyclic AMP