[Experimental study on myocardial protection with verapamil and salvia miltiorrhiza Bunge cardioplegia].
Myocardial 45Ca sequestration was studied in dogs during 60 minutes of global ischemia and 30 minutes of reperfusion using cardiopulmonary bypass (CPB) and myocardial function was studied before and after CPB. Group A (n = 5), as a control, received cold hyperkalemic cardioplegic solution, Group B (n = 5) received the same solution plus verapamil (150 micrograms/kg/L) and Group C plus specific activity (TSA = DPM x 10(4)/g) and plasma specific activity (PSA = DPM x 10(4)/ml) were determined by biopsy before and after release of the cross-clamp The results showed that myocardial function in Group B and C were better than that in Group A (P less than 0.01). It is suggested that verapamil and Salvia miltiorrhiza Bunge effectively control myocardial calcium sequestration during early reperfusion and reduce myocardial reperfusion injury As to myocardial protection, cardioplegia with verapamil and Salvia miltiorrhiza Bunge were superior to hyperkalemic alone. Verapamil cardioplegia was still better than Salvia miltiorrhiza Bunge.
Zhu
P
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First Affiliated Hospital of Jiangxi Medical College, Nanchang.
D000818:Animals; D015220:Calcium Channels; D002314:Cardioplegic Solutions; D002315:Cardiopulmonary Bypass; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D007036:Hypothermia, Induced; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010618:Phenanthrolines / Q000494:pharmacology*; D010936:Plant Extracts; D011188:Potassium; D027561:Salvia miltiorrhiza; D014700:Verapamil / Q000494:pharmacology*
D015220:Calcium Channels; D002314:Cardioplegic Solutions; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; C028972:dan-shen root extract; D014700:Verapamil; D011188:Potassium