Glucose metabolism, second messengers and insulin secretion.
Insulin secretion from beta cells of the islets of Langerhans in the endocrine pancreas is regulated by glucose, glucose metabolites, metabolic intermediates such as ATP, acetyl CoA and reduced pyridine nucleotides, and classical second messengers. Receptor responses transduced by guanine nucleotide binding proteins modulate metabolic activity, the generation of second messengers, and cell depolarization during stimulus-response coupling in the beta cell. This review will consider insulin secretion as regulated by glucose metabolic pathways and second messengers.
Laychock
S G
SG
Department of Pharmacology and Therapeutics, State University of New York, Buffalo 14214.
D000242:Cyclic AMP / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D015290:Second Messenger Systems
D007295:Inositol Phosphates; D007328:Insulin; D011453:Prostaglandins; D011942:Receptors, Adrenergic, alpha; D009249:NADP; D000242:Cyclic AMP; D005947:Glucose