title: Metastatic vulvar Paget's disease responding to combination chemotherapy: case report.
abstract: No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Mabuchi
authors.forename: I
authors.initials: I
authors.lastname: Kawabata
authors.forename: K
authors.initials: K
authors.lastname: Niwa
authors.forename: K
authors.initials: K
authors.lastname: Shimokawa
authors.forename: T
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen; D008937:Mitomycins; D016685:Mitomycin; D014750:Vincristine; D002945:Cisplatin