[Role of protein receptors of Vitamin A in the mechanism of antitumor action of retinoids].
Data on protein receptors of vitamin A participating in retinoid metabolism, storage, transport and action are presented. Information about cytosolic protein receptors of vitamin A exerting hormone-like action on the cell proliferation and differentiation is considered in detail. Data concerning the presence of protein receptors in normal and tumour tissues, correlation between protein receptors and biological retinoid effect are analyzed. A hypothetic model of the binding protein mode of action in target cells related to the action model of steroid hormones is described. The authors' own data on action of vitamin A and steroid hormones on the level of estrogen and progesterone receptors in the rate of mammary cancer are reviewed.
Piatchanina
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TV
Sidorik
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EP
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D046508:Culture Techniques; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012176:Retinoids / Q000378:metabolism / Q000494:pharmacology*; D012177:Retinol-Binding Proteins / Q000502:physiology*; D014801:Vitamin A / Q000494:pharmacology
D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012176:Retinoids; D012177:Retinol-Binding Proteins; C027928:retinol binding protein receptor; D014801:Vitamin A
Rol' belkovykh retseptorov vitamina A v mekhanizmakh protivoopukholevogo deĭstviia retinoidov.