[The role of the substantia nigra in the anticonvulsive and antiaggressive effects of diazepam during pharmacological kindling].
The seizure activity was investigated on the model of pharmacological kindling which was induced by repeated picrotoxin injections in the subthreshold dose, after the tryptic fragment of T5 protein-human diazepam binding inhibitor (DBI) (10 micrograms) injection into a reticular part of substantia nigra. An increase in the seizure reaction and suppression of the antiseizure diazepam action were observed. Intranigral DBI injection induced no change in a threshold of "attacks" in rats which were induced through electric shocks delivered to animals with an electrode floor and no changes in antiaggressive diazepam action were observed under such conditions.
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
Makul'kin
R F
RF
D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants; D003975:Diazepam / Q000494:pharmacology*; D026261:Diazepam Binding Inhibitor; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D008845:Microinjections / Q000379:methods; D009479:Neuropeptides / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D003975:Diazepam; D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010852:Picrotoxin; D011963:Receptors, GABA-A
Rol' chernoĭ substantsii v protivosudorozhnykh i antiagressivnykh éffektakh diazepama pri farmakologicheskom kindlinge.