[Synthetic immunogenic complexes containing a peptide from the surface protein of the foot-and-mouth disease virus].
Synthetic constructions containing a peptide antigenic determinant (C-terminal peptide 205-213 of the surface VP1 protein of the foot-and-mouth disease virus, O1K strain), glucosaminylmuramayl dipeptide (GMDP), and polyionic synthetic carriers were prepared. The polymerized peptide and peptide-BSA conjugates were synthesized as well. Among the constructions obtained only peptide-BSA conjugate proved to be highly immunogenic. Application of synthetic constructions to design immunogenic complexes is discussed.
Rar
V A
VA
Makarov
E A
EA
Iurovskiĭ
V V
VV
Meshcheriakova
E A
EA
Andronova
T M
TM
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000138:chemical synthesis / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D002213:Capsid / Q000138:chemical synthesis / Q000276:immunology*; D036022:Capsid Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000276:immunology; D014614:Vaccines, Synthetic / Q000138:chemical synthesis; D014765:Viral Vaccines / Q000138:chemical synthesis
D000956:Antigens, Viral; D036022:Capsid Proteins; D010455:Peptides; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; D012710:Serum Albumin, Bovine
Sinteticheskie immunogennye kompleksy na osnove peptida poverkhnostnogo belka virusa iashchera.