Stress induced alterations in striatal GABAA receptor complex.
The effect of cold-immobilized stress on the gamma-aminobutylic acid (GABA)/benzodiazepine (BZP) receptor complex in the rat striatum was examined. The stressful manipulation induced a significant decrease in the amount of [3H]muscimol binding sites in the striatal particulate fraction. On the other hand, [3H]flunitrazepam (FLN) binding and the enhancing effect of FLN or secobarbital on the [3H]muscimol binding to the striatal particulate fraction were not influenced by the stress treatment. These results suggest that cold-immobilized stress may selectively change GABAA receptor binding without altering BZP receptor binding as well as the functional coupling between GABAA and BZP receptors.
Zhang
M Y
MY
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Hashimoto
T
T
Kuriyama
K
K
D000818:Animals; D003080:Cold Temperature; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009118:Muscimol / Q000378:metabolism; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*; D012018:Reflex / Q000187:drug effects; D012149:Restraint, Physical; D012631:Secobarbital / Q000494:pharmacology; D013315:Stress, Psychological / Q000378:metabolism*
D011963:Receptors, GABA-A; D012631:Secobarbital; D009118:Muscimol; D005445:Flunitrazepam