title: Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques.
abstract: Pregnant macaques were used as a natural model for maternal-infant transmission of SRV-2 retrovirus. Fifty-one pregnant females were placed into one of four virus/antibody groups. Nonviremic mothers produced 100% virus-negative offspring at birth. In contrast, viremic mothers produced offspring which were 17% virus-negative and 83% virus-positive at birth. SRV-2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS.
authors.affiliation: Regional Primate Research Center, University of Washington, Seattle.
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: K E
authors.initials: KE
authors.lastname: Follis
authors.forename: K
authors.initials: K
authors.lastname: Snyder
authors.forename: S
authors.initials: S
authors.lastname: Windsor
authors.forename: M E
authors.initials: ME
authors.lastname: Thouless
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: W R
authors.initials: WR
authors.lastname: Morton
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D001724:Birth Weight; D005260:Female; D008254:Macaca nemestrina; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000382:microbiology; D015301:Retroviruses, Simian / Q000276:immunology / Q000302:isolation & purification; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology / Q000635:transmission*; D015996:Survival Rate; D014766:Viremia
chemical_list: D000914:Antibodies, Viral