title: Tissue-specific factors and glucocorticoid receptors present in nuclear extracts bind next to each other in the promoter region of mouse mammary tumor virus.
abstract: Nuclear extracts from different mouse tissues have been used to study the interaction of factors with the steroid-inducible promoter of mouse mammary tumor virus. In addition to the glucocorticoid receptor that interacts with the distal region of the promoter, several tissue-specific proteins were found to bind to the 5' flanking region of the receptor-binding site and to the basal promoter region. The differences in the pattern of protection observed suggest that tissue-specific factors might co-operate with steroid receptors and result in a cell-type-dependent modulation of hormone action.
authors.affiliation: Swiss Institute for Experimental Cancer Research, Epalinges.
authors.forename: T
authors.initials: T
authors.lastname: Meulia
authors.forename: H
authors.initials: H
authors.lastname: Diggelmann
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D001667:Binding, Competitive; D004252:DNA Mutational Analysis; D015967:Gene Expression Regulation, Viral; D046911:Macromolecular Substances; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism*; D009841:Oligonucleotides / Q000737:chemistry; D011401:Promoter Regions, Genetic; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014018:Tissue Distribution; D014158:Transcription, Genetic
chemical_list: D000911:Antibodies, Monoclonal; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D009841:Oligonucleotides; D011965:Receptors, Glucocorticoid