Neuroendocrine carcinoma of the oral cavity.
We report the clinical and pathologic features of a small cell neuroendocrine carcinoma arising in the oral cavity of a 63-year-old man. The tumor stained positively with neuron-specific enolase and had dense core granules ultrastructurally. Chemotherapy ordinarily given for pulmonary small cell carcinoma induced a clinical remission. When the tumor recurred 8 mo later, focal squamous differentiation was present within the neuroendocrine carcinoma. The patient died 2.5 yr after presentation.
Benning
T L
TL
Department of Pathology, Duke University, Durham, North Carolina.
Vollmer
R T
RT
Crain
B J
BJ
Shelburne
J D
JD
D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D005500:Follow-Up Studies; D005887:Gingival Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology*; D014057:Tomography, X-Ray Computed