Change in a complex translocation involving band 7q34 and 9p- in a case of T-cell lymphoblastic lymphoma.
The authors report a case of T-cell type non-Hodgkin's lymphoma (NHL) in which neoplastic cells possessed a three-way translocation involving chromosomal bands 3q21, 7q34, and 22q11, as well as partial monosomy of the short arm of chromosome 9. In the literature, most reported cases of 7q32-q36 abnormalities had T-cell type leukemia/lymphoma and were younger than 20 years. Two NHL cases, including the current case, were diagnosed as having lymphoblastic lymphoma with a leukemic transformation. The neoplastic cells of the reported cases commonly showed CD2 (E-rosette receptors) and CD38. All 17 patients but three manifested a mediastinal mass at diagnosis and seven had central nervous system lesions or pleural infiltration. Furthermore, five of the 19 reported cases also showed 9p- change.
Ohyashiki
K
K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Iwabuchi
A
A
Fujieda
H
H
Suzuki
A
A
Nakano
M
M
Ohyashiki
J H
JH
Toyama
K
K
Serizawa
H
H
Amemiya
R
R
Hayata
Y
Y
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D013601:T-Lymphocytes; D014178:Translocation, Genetic / Q000235:genetics*