title: Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
abstract: The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos), which binds to the 12-O-tetradecanoylphorbol-13-acetate-responsive element of the collagenase gene (collTRE). In contrast, the activity of another member of the AP-1 family that binds to the c-junTRE was not repressed. The mRNA expression of the c-jun gene was, in fact, strongly elevated in various cell types expressing the E1A gene of either adenovirus type 5 (Ad5) or Ad12. The regulation of the junB gene by adenovirus E1A, on the other hand, depended both on the cell type and on the transforming adenovirus serotype. The fact that E1A-induced alterations in the repertoire of AP-1 transcription factors depend on its transforming domain in conserved region 1 suggests that the effects are relevant for the transformation process.
authors.affiliation: Sylvius Laboratories, University of Leiden, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: van Dam
authors.forename: R
authors.initials: R
authors.lastname: Offringa
authors.forename: I
authors.initials: I
authors.lastname: Meijer
authors.forename: B
authors.initials: B
authors.lastname: Stein
authors.forename: A M
authors.initials: AM
authors.lastname: Smits
authors.forename: P
authors.initials: P
authors.lastname: Herrlich
authors.forename: J L
authors.initials: JL
authors.lastname: Bos
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Eb
mesh_terms: D017456:Adenovirus Early Proteins; D000260:Adenoviruses, Human / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D009857:Oncogenes; D011120:Polyomavirus / Q000235:genetics; D011401:Promoter Regions, Genetic; D016755:Proto-Oncogene Proteins c-jun; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D017456:Adenovirus Early Proteins; D004268:DNA-Binding Proteins; D009856:Oncogene Proteins, Viral; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D014157:Transcription Factors