Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.
The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical isolates, 12 (71%) had gyrA mutations and 1 (6%) had a gyrB mutation.
Yoshida
H
H
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Nakamura
M
M
Bogaki
M
M
Nakamura
S
S
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics*; D014170:Transformation, Genetic / Q000502:physiology
D042462:4-Quinolones; D000890:Anti-Infective Agents; D004250:DNA Topoisomerases, Type II