Influence of hydrazinophthalazines on the activity of collagenase in murine fibroblast culture.
Murine fibroblasts cultured in vitro were treated with hydrazinophthalazine drugs inducing the lupus erythematosus-like syndrome. Collagenase enzyme activity in the growth medium was found to be increased 3-fold by hydralazine and 1.8-fold by binazine, as compared to the control cultures. The enhanced level of collagenolytic activity points to the metabolic changes in the connective tissue in response to hydrazinophtalazines.
Weglarz
L
L
Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Drózdz
M
M
Wardas
M
M
D000818:Animals; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology; D006834:Hydrazines / Q000009:adverse effects / Q000494:pharmacology*; D051379:Mice; D003012:Microbial Collagenase / Q000096:biosynthesis / Q000378:metabolism*; D014032:Todralazine / Q000009:adverse effects / Q000494:pharmacology*
D006834:Hydrazines; C029424:hydrazine; D003012:Microbial Collagenase; D014032:Todralazine