[In vitro models for the analysis of inflammatory processes in sarcoidosis].
Currently there are no animal models available for interstitial lung diseases with unknown origin, such as sarcoidosis. Inflammatory cells obtained from patients have several disadvantages for the in-vitro verification of pathogenetical concepts. Thus, in-vitro models are desirable. Employing cell lines we present models that are suited to study the angiotensin-converting enzyme release and the production of oxygen radicals by activated macrophages and their fusion to giant cells.
Strausz
J
J
III. Medizinische Klinik, Schwerpunkt Pneumologie, Johannes Gutenberg Universität, Mainz.
Müller-Quernheim
J
J
D002460:Cell Line; D005609:Free Radicals; D006801:Humans; D008171:Lung Diseases / Q000276:immunology*; D008262:Macrophage Activation / Q000276:immunology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000276:immunology; D012507:Sarcoidosis / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D005609:Free Radicals; D013481:Superoxides; D007703:Peptidyl-Dipeptidase A
In-vitro Modelle zur Analyse von Entzündungsvorgängen bei Sarkoidose.