title: Ultrastructure of 26 cases of Ki-1 lymphomas: morphoimmunologic correlation.
abstract: Twenty-six cases of high-grade lymphomas with activation markers (CD30) classified and immunophenotyped according to the Kiel classification were studied to determine their fine structural features. Transmission electron microscopy showed in 17 cases anaplastic nuclear and cytoplasmic changes identical to those observed in Hodgkin's disease, it being impossible to determine by the morphology a B, T, or null nature. Four high-grade B-centroblastic and immunoblastic cases and five T-pleomorphic cases showed nuclear changes and cytoplasmic differentiation that suggested a T or B nature. An immunogold-labeling technique showed CD30-positive particles primarily in the Golgi complex and occasionally in the cell membrane.
authors.affiliation: Universidad Autónoma, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Rivas
authors.forename: M A
authors.initials: MA
authors.lastname: Piris
authors.forename: C
authors.initials: C
authors.lastname: Gamallo
authors.forename: A
authors.initials: A
authors.lastname: Barat
authors.forename: G
authors.initials: G
authors.lastname: Echezarreta
authors.forename: H
authors.initials: H
authors.lastname: Oliva
authors.forename: J L
authors.initials: JL
authors.lastname: Sarasa
authors.forename: F
authors.initials: F
authors.lastname: Rivas
authors.forename: G
authors.initials: G
authors.lastname: Renedo
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D000943:Antigens, Differentiation / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D017730:Ki-1 Antigen; D008223:Lymphoma / Q000145:classification / Q000276:immunology* / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000648:ultrastructure; D008854:Microscopy, Electron; D010641:Phenotype
chemical_list: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen