title: Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells.
abstract: The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 mumol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.
authors.affiliation: Department of Oral Pathology, University of Umeå, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Ljunggren
authors.forename: J
authors.initials: J
authors.lastname: Rosenquist
authors.forename: M
authors.initials: M
authors.lastname: Ransjö
authors.forename: U H
authors.initials: UH
authors.lastname: Lerner
mesh_terms: D001920:Bradykinin / Q000494:pharmacology*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis; D015232:Dinoprostone / Q000096:biosynthesis*; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000494:pharmacology
chemical_list: D010281:Parathyroid Hormone; D000242:Cyclic AMP; D015232:Dinoprostone; D001920:Bradykinin