Perchloric acid, toxicolor, endospecy, and miconazole in the early diagnosis and treatment of fungemia.
As a procedure for the diagnosis of fungemia, Toxicolor and Endospecy (limulus tests using a synthetic chromogenic substrate) were used to measure (1----3)-beta-D-glucan (beta-glucan), which is a membranous component of fungus. The plasma samples were pretreated with a new perchloric acid method. These methods permit measurement of the beta-glucan within about two hours. Patients in whom fungemia was diagnosed were effectively treated with miconazole.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Inoue
Y
Y
Amano
K
K
Yamada
A
A
Fujii
N
N
Nakamura
A
A
Nagasawa
T
T
Kikuchi
M
M
Taki
K
K
Hoshi
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005658:Fungi / Q000302:isolation & purification*; D005936:Glucans / Q000032:analysis; D006801:Humans; D008033:Limulus Test; D008297:Male; D008825:Miconazole / Q000627:therapeutic use*; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D010472:Perchlorates; D047071:beta-Glucans
D005936:Glucans; D010472:Perchlorates; D047071:beta-Glucans; D008825:Miconazole; C033363:beta-1,3-glucan