Carnosine as a potential scavenger of oxidants generated by stimulated neutrophils.
Luminol-dependent chemiluminescence of PMA-stimulated human neutrophils decrease more than by 50% in the presence of physiological concentrations of carnosine (20 mM). This inhibition is the result of carnosine ability to scavenge hypochlorite (OCl-), since carnosine exerts a similar effect on chemiluminescence produced by myeloperoxidase-H2O2-Cl- and OCl(-)-H2O2 systems. The previously undocumented property of this dipeptide to scavenge active oxygen species requires further experiments.
Sharonov
B P
BP
All Union Research Institute of Highly Pure Biopreparations, Leningrad, USSR.
Govorova NJu
Lyzlova
S N
SN
D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D006997:Hypochlorous Acid / Q000097:blood; D007700:Kinetics; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D009195:Peroxidase / Q000097:blood
D004151:Dipeptides; D005609:Free Radicals; D006997:Hypochlorous Acid; D002336:Carnosine; D006861:Hydrogen Peroxide; D009195:Peroxidase; D010100:Oxygen