[Catecholamine-induced changes of the kinetic properties of adrenergic receptors of the myocardium].
The pattern of changes in kinetic properties of beta-adrenoreceptor (Cd, c+ and c-) relative to anapriline adrenoblocker under conditions of muscle perfusion by catecholamines has been estimated on papillary cardiac muscles of the rat as based on the isometric voltage. A priority increase of the receptors' affinity to the blocker is determined, that may be a result of changes in microviscosity of the lipid sarcolemma bilayer.
Kozlov
A G
AG
Radchenko
N F
NF
Marchenko
S N
SN
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004837:Epinephrine / Q000493:pharmacokinetics / Q000494:pharmacology*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine
Izmenenie kineticheskikh svoĭstv adrenoretseptorov serdechnoĭ myshtsy pri deĭstvii katekholaminov.