Diffusional and electrokinetic redistribution at the synapse: a physicochemical basis of synaptic competition.
Coinnervating nerve terminals may compete for "stabilizing factors" confined within the postsynaptic cell. The competition could be achieved through a diffusion-mediated trapping the factor, facilitated by an activity-dependent electrokinetic migration of the factor toward the synaptic site. We have examined the evidence for diffusional and electrokinetic motions of cell surface and cytoplasmic components, the profile and magnitude of the electric field produced by the synaptic current, and the plausibility that these motions underlie the process of synaptic competition.
Poo
M M
MM
Department of Biological Sciences, Columbia University, New York, New York 10027.
Young
S H
SH
D000818:Animals; D008959:Models, Neurological; D009473:Neuronal Plasticity; D013569:Synapses / Q000378:metabolism / Q000502:physiology*