[Visceral leishmaniasis. Personal observation and review of epidemiology, clinical aspects and therapy].
A 5 year old German girl contracted visceral leishmaniasis during a vacation in Spain, either 32 or 20 month prior to the manifestation of disease. She presented with fever, hepatosplenomegaly and pancytopenia. A bone marrow aspirate proved the diagnosis. Therapy with a pentavalent antimony drug brought about immediate improvement. Visceral leishmaniasis has to be suspected in individuals with fever, hepatosplenomegaly and pancytopenia who have resided in endemic areas (Mediterranean countries, India, East Africa, South America) during the previous years. If untreated, visceral leishmaniasis runs a fatal course. Therefore, early diagnosis by morphological and serological means and specific therapy with pentavalent antimony drugs are mandatory.
Dickerhoff
R
R
Universitäts-Kinderklinik, Abteilung Hämatologie/Onkologie.
Müller
A
A
Bode
U
U
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D001853:Bone Marrow / Q000469:parasitology*; D002675:Child, Preschool; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007893:Leishmania donovani / Q000254:growth & development / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010198:Pancytopenia / Q000209:etiology; D013163:Splenomegaly / Q000209:etiology
D000967:Antimony Sodium Gluconate
Die viszerale Leishmaniose. Eigene Beobachtung und Ubersicht über Epidemiologie, Klinik und Therapie.