[The antinociceptive properties of dalargin as an agent of anesthesiologic protection].
The antinociceptive properties of dalargin (D) under nembutal anesthesia and artificial ventilation were studied in hemodynamic response to mechanical algesic stimulation in rats. D was introduced i/v (20 micrograms/kg) against a background of myoplegia with Arduan (0.1 mg/kg) and without it. The naloxon (100 micrograms/kg) prevented the protective effects of D. It is considered that injection of D (20 micrograms/kg) on the background of total myoplegia and artificial ventilation prevented hemodynamic response on algesic stimulus. Subsequent dose increase of opium peptide up to 3500 micrograms/kg does not cause amplification of protective properties.
Shloznikov
B M
BM
Donich
S G
SG
Grebenchikova
O A
OA
Makhmutov
R F
RF
Likhvantsev
V V
VV
Kuznetsov
A Iu
AIu
Peretrukin
A I
AI
Fomchenkov
E P
EP
D000700:Analgesics / Q000494:pharmacology*; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D009125:Muscle Relaxants, Central; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Izuchenie antinotsitseptivnykh svoĭstv dalargina v kachestve sredstva anesteziologicheskoĭ zashchity.