title: Doppler umbilical and uterine flow waveforms in severe pregnancy hypertension.
abstract: Doppler studies of the umbilical and uteroplacental bed arterial flow velocity waveforms were performed in a series of women suffering from severe proteinuric pregnancy hypertension. Ninety-five women were studied and the mean interval between the last study and delivery was 1.4 days. An abnormally elevated umbilical artery systolic:diastolic (AB) ratio was present in 61 (64%) of the women. All 10 perinatal deaths were associated with pregnancies with an abnormal umbilical artery AB ratio. An elevated umbilical artery AB ratio was significantly associated with small-for-gestation and neonatal morbidity. Infants associated with extremely high umbilical artery AB ratios (greater than or equal to 99th centile) spent twice as long in the neonatal nursery as those with a lower value. There was no relation between the duration of hypertension and the umbilical study result. The uteroplacental bed artery flow velocity waveform did not correlate with fetal or neonatal mortality or morbidity. Patients with abnormal uteroplacental AB ratios also had abnormal umbilical artery AB ratios. We conclude that an abnormal fetal umbilical artery Doppler flow velocity waveform correlates with adverse fetal outcome in severe proteinuric pregnancy hypertension and suggest that the associated placental lesion may precede the maternal hypertension.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Sydney, Westmead Hospital, NSW, Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Trudinger
authors.forename: C M
authors.initials: CM
authors.lastname: Cook
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D011256:Pregnancy Outcome; D013997:Time Factors; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000503:physiopathology*; D014599:Uterus / Q000098:blood supply*