title: 3'-5' cAMP phosphodiesterase in pig liver nuclei.
abstract: cAMP phosphodiesterase was partially purified from pig liver nuclei and some of its properties were investigated. The enzyme is a low km PDE. Inhibition by xanthine derivatives is in line with the behaviour of PDE from other mammalian sources, while small differences are observed towards nucleotides inhibitors. The enzyme is a chromatin-bound protein although no specific location related to transcriptional function could be demonstrated.
authors.affiliation: Dipartimento di Biologia Cellulare, Università di Camerino.
authors.forename: G
authors.initials: G
authors.lastname: Lupidi
authors.forename: M
authors.initials: M
authors.lastname: Eufemi
authors.forename: S
authors.initials: S
authors.lastname: Luciani
authors.forename: A
authors.initials: A
authors.lastname: Ferraro
authors.forename: F
authors.initials: F
authors.lastname: Riva
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000201:enzymology*; D002843:Chromatin / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D013045:Species Specificity; D013552:Swine
chemical_list: D002843:Chromatin; D015105:3',5'-Cyclic-AMP Phosphodiesterases