Generation of leukotriene B4 and C4 from granulocytes of normal controls, allergic rhinitis, and asthmatic subjects.
We determined the relationship of allergic disease to the number and activity of eosinophils and their production of leukotriene B4 and leukotriene C4 (leukotriene D4 equivalents). Granulocytes from allergic rhinitis (AR) subjects and asthmatics release more LTC4 than normals. Furthermore, eosinophils of asthmatics generate more LTC4 than those of AR subjects.
Kohi
F
F
Allergic Disease Center, Creighton University, Omaha, NE.
Miyagawa
H
H
Agrawal
D K
DK
Bewtra
A K
AK
Townley
R G
RG
D000328:Adult; D001249:Asthma / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D007975:Leukotriene B4 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000378:metabolism*; D013189:SRS-A / Q000378:metabolism*; D013223:Statistics as Topic
D013189:SRS-A; D007975:Leukotriene B4; D000001:Calcimycin