T cell receptor beta-chain gene rearrangement without gamma-chain gene rearrangement in cutaneous T cell lymphoma: an unusual finding.
T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor beta-chain gene in the absence of rearrangement of the gamma-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.
Ho
V C
VC
Department of Dermatology, University of Michigan, Ann Arbor 48109.
Hansen
E R
ER
Elder
J T
JT
Baadsgaard
O
O
Vejlsgaard
G L
GL
Hanson
C A
CA
Cooper
K D
KD
D000368:Aged; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics*; D013601:T-Lymphocytes