title: Xanthine oxidase generation of toxic oxygen metabolites in acute uveitis.
abstract: Lodoxamide, a xanthine oxidase inhibitor, has antiphlogistic effects in the treatment of acute uveitis. The role of xanthine oxidase generated free radicals is discussed.
authors.affiliation: Center for Sight, Georgetown University, Washington, D.C.
authors.forename: G E
authors.initials: GE
authors.lastname: Marak
authors.forename: G O
authors.initials: GO
authors.lastname: Till
authors.forename: P A
authors.initials: PA
authors.lastname: Ward
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004341:Drug Evaluation; D009877:Endophthalmitis / Q000188:drug therapy / Q000378:metabolism; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013481:Superoxides / Q000378:metabolism*; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D013481:Superoxides; D014969:Xanthine Oxidase; D010072:Oxamic Acid; C021702:lodoxamide ethyl