[Allelic losses on chromosomes 1p, 3p, 11p, 11q in non small cell lung cancers].
Recent studies have shown that lung cancer patients frequently suffer inactivation of antioncogenes such as Rb gene (13q14) and p53 gene (17p13). In a study of 48 cases of non-small cell lung cancer (28 squamous-cell carcinomas, 11 adenocarcinomas, 4 large-cell carcinomas, and 5 other types) using restriction fragment length polymorphism analysis, we found DNA sequence deletions from chromosomes 1p32-36, 3p21, 11p15.5, and 11q13. The frequencies of allele loss on chromosome 1p, 3p, 11p and 11q are 31, 57, 20 and 49% of informative cases in this patient group, respectively. Of them, 19 tumors show one allele loss and 10 patients suffer two or more allele losses from different chromosomes.
Cheng
J Q
JQ
Université de Paris-Nord, Institut d'Oncologie cellulaire et moléculaire humaine, Bobigny.
Crépin
M
M
Hamelin
R
R
D000230:Adenocarcinoma / Q000235:genetics; D000483:Alleles; D015139:Blotting, Southern; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D006579:Heterozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*
Pertes d'allèles sur les chromosomes 1p, 3p, 11p et 11q dans les cancers du poumon non à petites cellules.