High density lipoprotein is a scavenger of superoxide anions.
Present work describes a new property of HDL to act as a scavenger of O2- free radicals in vitro. This lipoprotein prevents both enzymic and non-enzymic generation of O2- anions as evidenced by inhibition of xanthine oxidase, peroxidase, peroxidation of pyrogallol and phenazine methosulphate-NADH reaction. Ascorbate stimulated MDA formation in microsomes has been shown to be suppressed by HDL and these effects are comparable with that of BHA.
Chander
R
R
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Kapoor
N K
NK
D000818:Animals; D000838:Anions / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D016166:Free Radical Scavengers; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D013481:Superoxides / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000378:metabolism
D000838:Anions; D016166:Free Radical Scavengers; D008075:Lipoproteins, HDL; D013481:Superoxides; D002083:Butylated Hydroxyanisole; D008315:Malondialdehyde; D009249:NADP; D009195:Peroxidase; D014969:Xanthine Oxidase; D001205:Ascorbic Acid