title: Familial cystic hygroma with normal karyotype.
abstract: A patient is described who had three consecutive fetuses with cystic hygroma and hydrops, two of which had documentation of normal karyotype. Some twenty percent of fetuses with cystic hygroma have a normal karyotype, and many of these have other major malformations. An autosomal recessive pattern of inheritance has been postulated, but cystic hygroma may also occur in association with a variety of syndromes, some of which have other patterns of inheritance.
authors.affiliation: Maternal Fetal Medicine, University of North Carolina, Chapel Hill 27599-7570.
authors.forename: W J
authors.initials: WJ
authors.lastname: Watson
authors.forename: J M
authors.initials: JM
authors.lastname: Thorp
authors.forename: J W
authors.initials: JW
authors.lastname: Seeds
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000235:genetics; D007621:Karyotyping; D008202:Lymphangioma / Q000175:diagnosis / Q000235:genetics*; D011247:Pregnancy; D014463:Ultrasonography