Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats.
The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.
De-la-Cruz
F
F
Department of Physiology, National School of Biological Sciences, IPN, Mexico, D.F.
Soto-Mora
M L
ML
Uriostegui
T
T
Russek
M
M
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D006815:Hunger / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D004837:Epinephrine; D010646:Phentolamine