Neutralizing antibodies to all seven serotypes of foot-and-mouth disease virus elicited by synthetic peptides.
Uncoupled peptides from all seven serotypes of foot-and-mouth disease virus (FMDV) protein VP1 have been used to elicit neutralizing antibody responses in guinea-pigs. The responses were largely serotype specific, although some significant cross-neutralization was observed. Dimeric tandem peptides have also been used to simultaneously elicit neutralizing antibodies to two different FMDV serotypes. The possible existence of structural features common to the B-cell neutralization sites or the guinea-pig helper T-cell sites within all seven peptides are analysed and discussed.
Francis
M J
MJ
Department of Virology, Wellcome Biotechnology Ltd, Beckenham, Kent, U.K.
Hastings
G Z
GZ
Clarke
B E
BE
Brown
A L
AL
Beddell
C R
CR
Rowlands
D J
DJ
Brown
F
F
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000918:Antibody Specificity; D005537:Aphthovirus / Q000145:classification / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D012703:Serotyping; D015678:Viral Structural Proteins / Q000276:immunology
D000914:Antibodies, Viral; D010455:Peptides; D015678:Viral Structural Proteins