Carcinosarcoma arising in eccrine spiradenoma. A clinicopathologic and immunohistochemical study of two cases.
Malignant change in a benign eccrine spiradenoma is rare. Only 13 such cases have been previously reported. Two further cases are described herein, both of which were carcinosarcomas and arose in middle-aged women. In each case continuity was demonstrated between the benign and malignant epithelial components and the sarcomatous element. In case 1 the sarcomatous component showed osteocartilaginous and rhabdomyoblastic differentiation, whereas in case 2 only osteosarcoma was evident. To our knowledge, carcinosarcoma has not been previously described arising in eccrine spiradenoma. The literature regarding malignant eccrine spiradenoma is reviewed.
McKee
P H
PH
Department of Histopathology, St. Thomas's Hospital Medical School, London, England.
Fletcher
C D
CD
Stavrinos
P
P
Pambakian
H
H
D006607:Adenoma, Sweat Gland / Q000032:analysis / Q000473:pathology*; D002296:Carcinosarcoma / Q000032:analysis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013544:Sweat Gland Neoplasms / Q000032:analysis / Q000473:pathology*