[Calmodulin blockaders weaken the short-term plasticity of the neuronal cholinoreceptors in the edible snail].
By means of recording transmembrane ion currents of identified snail neurones PPa3 and LPa3 a reversible weakening was shown of the speed and depth of extinction of neuronal cholinoreceptor membrane reactions to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockaders: R24571 (20-50 mmol/l), trifluoperazine (50-200 mmol/l), chlorpromazine (20-60 mmol/l) and prenylamine lactate (30-400 mmol/l). The obtained results testify to a positive control by calmodulin of short-term cholinoreceptors plasticity of the studied neurons.
Pivovarov
A S
AS
Drozdova
E I
EI
Kotliar
B I
BI
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000502:physiology; D006372:Helix, Snails / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology
D002147:Calmodulin; D011950:Receptors, Cholinergic; D000109:Acetylcholine
Blokatory kal'modulina oslabliaiut kratkovremennuiu plastichnost' kholinoretseptorov neĭronov vinogradnoĭ ulitki.