Cholesterotic fibrous histiocytoma. Its association with hyperlipoproteinemia.
A 63-year-old woman with fibrous histiocytomas showed cholesterol deposition in the setting of type IIB hyperlipidemia. The two lesions involved the left leg and right thigh. One had typical features of a fibrous histiocytoma including changes of the overlying epidermis. The other was essentially replaced by cholesterol deposits and could not be differentiated from a tuberous xanthoma. This case illustrates the histiocytic response of fibrous histiocytomas to a hyperlipoproteinemic microenvironment.
Hunt
S J
SJ
Cutaneous Pathology, St John's Mercy Medical Center, St Louis, MO 63141-8221.
Santa Cruz
D J
DJ
Miller
C W
CW
D002784:Cholesterol / Q000032:analysis; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis / Q000473:pathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D007866:Leg; D008875:Middle Aged; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*
D002784:Cholesterol