Role of the CD28 receptor in T-cell activation.
Antigen-specific T-cell activation is initiated through the T-cell receptor. Recent evidence has shown that a number of additional T-cell surface receptors serve to regulate the responses of antigen-activated T cells. One such molecule, CD28, is a member of a heterophilic cell adhesion complex, and is the receptor for the B-cell-restricted B7/BB-1 antigen. As Carl June, Jeffrey Ledbetter, Peter Linsley and Craig Thompson review here, CD28 serves as the surface component of a novel signal transduction pathway that modulates T-cell lymphokine production and increases the resistance of T-cell responses to various immunosuppressive agents.
June
C H
CH
Naval Medical Research Institute, Bethesda, MD 20814.
Ledbetter
J A
JA
Linsley
P S
PS
Thompson
C B
CB
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D006801:Humans; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D011948:Receptors, Antigen, T-Cell