Density-dependent nerve growth factor regulation of Gs-alpha RNA in pheochromocytoma 12 cells.
Nerve growth factor (NGF) affects levels of the alpha subunit of the stimulatory G protein (Gs-alpha) in pheochromocytoma 12 cells in a bidirectional, density-dependent manner. Cells grown at high density responded to NGF treatment with increased levels of Gs-alpha mRNA and protein. Conversely, in cells grown in low-density cultures, levels of this mRNA were lowered by NGF treatment.
Tjaden
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G
Department of Biology, New York University, New York 10003.
Aguanno
A
A
Kumar
R
R
Benincasa
D
D
Gubits
R M
RM
Yu
H
H
Dolan
K P
KP
D000310:Adrenal Gland Neoplasms; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D046911:Macromolecular Substances; D009414:Nerve Growth Factors / Q000494:pharmacology*; D010673:Pheochromocytoma; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics*; D012334:RNA, Neoplasm / Q000187:drug effects / Q000235:genetics; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D046911:Macromolecular Substances; D009414:Nerve Growth Factors; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D002772:Cholera Toxin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins