Subclinical lithium neurotoxicity: correlation of neural conduction abnormalities and serum lithium level in manic-depressive patients with lithium treatment.
Nerve conduction velocities (NCVs) and multimodality evoked potentials were studies in 28 manic-depressive patients under lithium prophylaxis with serum lithium levels between 0.320 and 0.980 mEq/L. Slowing of motor and sensory NCVs and prolonged central neural conduction times obtained from somatosensory and brainstem auditory evoked potentials were found to correlate with serum lithium levels. Lithium-induced changes in cell membrane conductivity and in the synaptic transmission are considered responsible for the neurotoxic effects of lithium.
Chang
Y C
YC
Department of Neurology, National Taiwan University Hospital, Taipei, R.o.C.
Lin
H N
HN
Deng
H C
HC
D000328:Adult; D000553:Ambulatory Care; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D001827:Body Height; D004359:Drug Therapy, Combination; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013696:Temperature
D008094:Lithium