Gastric mucosal bleeding after unfractionated and low molecular weight heparin in rats.
The bleeding from an induced gastric mucosal lesion was monitored after intravenous administration of unfractionated heparin and enoxaparin, a low molecular weight heparin. The gastric mucosa was exposed in a chamber, which was superfused with saline and emptied at 1-min intervals for quantitation of bleeding. Both heparins prolonged the bleeding time and increased the blood loss dose-dependently. Five to ten times higher doses of enoxaparin (in terms of anti-Xa units) were required to achieve similar prolongation of the bleeding times as with unfractionated heparin. The results indicate a more favourable antihaemostatic effect of enoxaparin than of unfractionated heparin.
Bang
C J
CJ
Medical Dept., Haukeland University Hospital, Bergen, Norway.
Berstad
A
A
Talstad
I
I
D000818:Animals; D001760:Bleeding Time; D004305:Dose-Response Relationship, Drug; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006493:Heparin / Q000008:administration & dosage / Q000633:toxicity*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin