Acute alterations of cyclo(His-Pro) levels after oral ingestion of glucose.
We analyzed the response of plasma cyclo(His-Pro) (CHP) (N = 14), insulin (N = 8), and glucose (N = 8) to oral ingestion of 75 grams of glucose in normal volunteers. Mean Fasting CHP levels prior to glucose were 614 +/- 112 pg/ml (+/-SE). After glucose ingestion there occurred an acute rise of plasma CHP within 15 minutes (12/14) followed by a fall in plasma concentrations to below baseline values (11 of 14). The mean of highest levels within the first 15 minutes after glucose ingestion was 1035 +/- 300 pg/ml (+/-SE), significantly above baseline (p = 0.002). The mean of lowest values below baseline was 490 +/- 94 pg/ml (+/-SE), p less than 0.001. We conclude that levels of CHP are acutely and reversibly altered by the ingestion of glucose. The possible significance of these perturbations in CHP concentrations is discussed.
Hilton
C W
CW
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Prasad
C
C
Wilber
J F
JF
D001786:Blood Glucose / Q000378:metabolism; D004032:Diet; D005215:Fasting; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000097:blood / Q000378:metabolism*; D010879:Piperazines / Q000097:blood / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D010456:Peptides, Cyclic; D010879:Piperazines; D005947:Glucose; C015924:histidyl-proline diketopiperazine