title: Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. I. Chromosome analysis in bone marrow and spermatocytes.
abstract: Clofazimine, an antileprosy drug, was tested for its cytogenetic effect in mouse bone marrow and testis. Bone marrow metaphase analysis in adults treated directly for different periods (1, 2 and 4 weeks, 40 mg/kg/day) and with different doses (4, 20 and 40 mg/kg/day for 7 days) as well as in young animals exposed through lactation for different periods (2, 3, and 4 weeks) revealed significant increases in chromosomal aberrations over the controls. Analysis of diakinesis-metaphase I stages also exhibited a significantly elevated incidence of chromosome aberrations over controls after treatment for different periods. On the basis of the present result the drug may be considered a potential clastogen in mice.
authors.affiliation: Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Das
authors.forename: B
authors.initials: B
authors.lastname: Roy
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002991:Clofazimine / Q000378:metabolism / Q000633:toxicity*; D006878:Hydroxides; D017665:Hydroxyl Radical; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013090:Spermatocytes / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000927:Anticonvulsants; D006878:Hydroxides; D017665:Hydroxyl Radical; D002991:Clofazimine