title: Dextromethorphan sites, sigma receptors, and the psychotomimetic effects of sigma opiates.
abstract: A review of the literature shows that the dysphoric and psychotomimetic side effects of opiate agonist-antagonist reside in the opiate levorotatory isomer. Thus, the current definition of the sigma receptor cannot explain the psychotomimetic effects of sigma opiates.
authors.affiliation: Department of Pharmacology, N.Y.U. School of Medicine, NY 10016.
authors.forename: J M
authors.initials: JM
authors.lastname: Musacchio
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: P D
authors.initials: PD
authors.lastname: Canoll
mesh_terms: D000818:Animals; D001665:Binding Sites; D003915:Dextromethorphan / Q000378:metabolism* / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D006213:Hallucinogens; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017480:Receptors, sigma; D013237:Stereoisomerism
chemical_list: D004723:Endorphins; D006213:Hallucinogens; D011957:Receptors, Opioid; D017480:Receptors, sigma; D007981:Levorphanol; D003915:Dextromethorphan