Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients.
Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age- and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.
Ebstein
R P
RP
Department of Psychiatric Research, Ezrath Nashim Hospital, Jerusalem, Israel.
Bennett
E R
ER
Hadjez
J
J
Silver
H
H
Yedgar
S
S
Lerer
B
B
D000262:Adenylyl Cyclases / Q000235:genetics; D002461:Cell Line, Transformed; D000242:Cyclic AMP / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D015290:Second Messenger Systems / Q000502:physiology*
D000242:Cyclic AMP; D000262:Adenylyl Cyclases