Fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase during liver regeneration.
Glycogen and fructose 2,6-bisphosphate levels in rat liver decreased quickly after partial hepatectomy. After 7 days the glycogen level was normalized and fructose 2,6-bisphosphate concentration still remained low. The 'active' (non-phosphorylated) form of 6-phosphofructo-2-kinase varied in parallel with fructose 2,6-bisphosphate levels, whereas the 'total' activity of the enzyme decreased only after 24 h, similarly to glucokinase. The response of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from hepatectomized rats (96 h) to sn-glycerol 3-phosphate and to cyclic AMP-dependent protein kinase was different from that of the enzyme from control animals and similar to that of the foetal isoenzyme.
Rosa
J L
JL
Departement de Ciències Fisiològiques Humanes i de la Nutrició, Universitat de Barcelona, L'Hospitalet, Spain.
Ventura
F
F
Carreras
J
J
Bartrons
R
R
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005635:Fructosediphosphates / Q000378:metabolism*; D005941:Glucokinase / Q000378:metabolism; D005994:Glycerophosphates / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D025481:Phosphofructokinase-2; D010770:Phosphotransferases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005635:Fructosediphosphates; D005994:Glycerophosphates; D007527:Isoenzymes; D008112:Liver Glycogen; C027652:fructose 2,6-diphosphate; D000242:Cyclic AMP; D010770:Phosphotransferases; D011494:Protein Kinases; D006593:Hexokinase; D025481:Phosphofructokinase-2; D005941:Glucokinase