Effect of staurosporine on the phorbol ester-induced activation of the Na+/H+ antiporter in smooth muscle cells.
Evidence is presented suggesting that the Na+/H+ antiporter activity of aortic smooth muscle cells is stimulated by protein kinase C activation. However, once the transporter has been activated, inhibitors of protein kinase C are not effective, supporting a model in which the Na+/H+ antiporter conserves memory of its activation by protein kinase C.
Boscoboinik
D O
DO
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Hensey
C E
CE
Azzi
A
A
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D002352:Carrier Proteins / Q000378:metabolism*; D002478:Cells, Cultured; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017923:Sodium-Hydrogen Exchangers; D019311:Staurosporine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D000470:Alkaloids; D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers; D011493:Protein Kinase C; D019311:Staurosporine; D013755:Tetradecanoylphorbol Acetate