Resolution of severe thrombocytopenia in a pregnant patient with rhesus-negative blood with autoimmune thrombocytopenic purpura after intravenous rhesus immune globulin.
Treatment with 120 micrograms of intravenous rhesus immune globulin at 29 1/2 weeks' gestation resulted in an elevation of the platelet count from 38,000/mm3 to 73,000/mm3 in a patient with rhesus-negative blood with autoimmune thrombocytopenic purpura. Red blood cell immune blockade of the reticuloendothelial system is probably not the primary mechanism by which rhesus immune globulin elevates the platelet count.
Moise
K J
KJ
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
Cano
L E
LE
Sala
D J
DJ
D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood / Q000628:therapy*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000628:therapy*; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000628:therapy*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin; D013921:Thrombocytopenia / Q000097:blood / Q000628:therapy*
D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin