Further studies on factors controlling phenotypic susceptibility of Candida albicans to miconazole kill.
A growth-limiting medium was used for further studies on growth phase-dependent shifts in susceptibility of Candida albicans to direct lethal miconazole action. Restricted nutrition did not affect development of susceptibility. Reestablishment of resistance toward stationary phase was not a physiological response to nutrient exhaustion. Resistance developed even at low population density if cells were in physiological transition to stationary phase with glucose available.
Beggs
W H
WH
General Medical Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417.
D002176:Candida albicans / Q000187:drug effects*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010641:Phenotype
D003470:Culture Media; D008825:Miconazole