[The suppression of the contractile activity of the cardiomyocytes by dermorphin in a heart culture of newborn rats].
Opioid peptides exert ino- and chronotropic effects on the heart. Paraopioid dermorphine (Y-dA-F-G-Y-P-S) was earlier shown to act as negative inotropic agent in isolated frog's hearts. In this study, the same effect was investigated in cultured myocardiac cells of the newborn rats. Dermorphine (10(-4)-10(-9) M) dose-dependently attenuated the contraction amplitude with the latency of 5-10 min. The peak of the response appeared in 30-45 min after application of dermorphine. The mu-opiate-receptor antagonist naloxone (10(-5) g/ml) blocked this effect. Dermorphine seems to exert its negative inotropic action through the opiate receptors, presumably of the mu-subtype.
Ivanova
N L
NL
Leĭkina
M I
MI
Sokolova
N A
NA
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured / Q000187:drug effects / Q000502:physiology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D013997:Time Factors
D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D009270:Naloxone
Podavlenie sokratitel'noĭ aktivnosti kardiomiotsitov dermorfinom v kul'ture serdtsa novorozhdennykh krysiat.