[Antiradical and antioxidant effect of arginine and its action on lipid peroxidation in hypoxia].
Arginine (0.5 and 1 mu mol) decreased by 14-17% rates of superoxide anion formation in two systems: HADH-phenazine methosulfate and hydroxylamine autooxidation with nitrotetrazolium blue. These concentrations of arginine decreased by 40-50% formation of diene conjugates and Schiff bases in plasma when lipid peroxidation initiated by iron -ascorbate. Arginine administration before hypoxia decreased lipid peroxidation rate in plasma and liver microsomal membranes of rats.
Miliutina
N P
NP
Ananian
A A
AA
Shugaleĭ
V S
VS
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D005609:Free Radicals; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008773:Methylphenazonium Methosulfate / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D012545:Schiff Bases; D013481:Superoxides / Q000378:metabolism; D013778:Tetrazolium Salts / Q000378:metabolism
D005609:Free Radicals; D006898:Hydroxylamines; D012545:Schiff Bases; D013778:Tetrazolium Salts; C042207:4-anisyltetrazolium blue; D013481:Superoxides; D008773:Methylphenazonium Methosulfate; D019811:Hydroxylamine; D001120:Arginine
Antiradikal'nyĭ i antioksidantnyĭ éffekt arginina i ego vliianie na aktivnost' perekisnogo okisleniia lipidov pri gipoksii.