title: Low-dose antacids versus 400 mg cimetidine twice daily for reflux oesophagitis. A comparative, placebo-controlled, multicentre study.
abstract: Ninety-one patients with reflux oesophagitis were randomly allocated to treatment with one chewable antacid tablet (acid-neutralizing capacity, 30 mmol) four times daily, 400 mg cimetidine twice daily, or placebo. The study was double-blind, with a double-dummy technique. Endoscopy was performed before inclusion and after 8 weeks' treatment. Symptoms were recorded on diary cards and on visual analogue scales. Statistically significant healing of oesophagitis was achieved in all three treatment groups, but none of the active regimens were significantly superior to placebo. Symptoms were significantly reduced with both cimetidine and antacids compared with placebo. Patients taking antacids consumed significantly less extra antacids for pain relief and had significantly better global assessment score than patients taking cimetidine during the first and second half of the study, respectively. In conclusion, neither cimetidine nor antacids were significantly superior to placebo in healing of reflux oesophagitis. Both the active regimens were superior to placebo for symptomatic relief.
authors.affiliation: Dept. of Medicine, Gjøvik County Hospital, Norway.
authors.forename: P G
authors.initials: PG
authors.lastname: Farup
authors.forename: R
authors.initials: R
authors.lastname: Weberg
authors.forename: A
authors.initials: A
authors.lastname: Berstad
authors.forename: S
authors.initials: S
authors.lastname: Wetterhus
authors.forename: O
authors.initials: O
authors.lastname: Dahlberg
authors.forename: J
authors.initials: J
authors.lastname: Dybdahl
authors.forename: G
authors.initials: G
authors.lastname: Fyllingen
authors.forename: K S
authors.initials: KS
authors.lastname: Kannelønning
authors.forename: O J
authors.initials: OJ
authors.lastname: Lange
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000863:Antacids / Q000008:administration & dosage*; D002927:Cimetidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010146:Pain / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic
chemical_list: D000863:Antacids; D002927:Cimetidine