title: Comparative effects of three cereal brans on plasma lipids, blood pressure, and glucose metabolism in mildly hypercholesterolemic men.
abstract: Dietary fiber lowers atherogenic serum lipids and blood pressure and improves glucose metabolism. We compared in 24 mildly hypercholesterolemic men the effects of adding 11.8 g dietary fiber/d from each of three cereal brans (wheat, rice, and oat) to a low-fiber diet for 4 wk each. A double-blind, crossover design incorporated brans into bread and muffins. Plasma total- and low-density-lipoprotein-cholesterol concentrations were significantly lowered only by oat bran. Compared with wheat bran, the ratios of plasma high-density-lipoprotein cholesterol to total cholesterol and of apolipoprotein A-I to B were significantly increased with oat bran (both by 4.7%, P less than 0.05), and rice bran (2.3%, P less than 0.05, and 3.9%, P less than 0.05, respectively). Blood pressure, blood glucose, and serum insulin responses to a common test meal were unaltered. Oat and rice bran exert a small but potentially useful effect on plasma lipoprotein risk factors for cardiovascular disease.
authors.affiliation: CSIRO Division of Human Nutrition, Adelaide, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Kestin
authors.forename: R
authors.initials: R
authors.lastname: Moss
authors.forename: P M
authors.initials: PM
authors.lastname: Clifton
authors.forename: P J
authors.initials: PJ
authors.lastname: Nestel
mesh_terms: D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012275:Oryza; D011134:Polysaccharides / Q000494:pharmacology; D014908:Triticum
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001786:Blood Glucose; D004043:Dietary Fiber; D008055:Lipids; D008075:Lipoproteins, HDL; D011134:Polysaccharides