title: Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery.
abstract: A case of a giant cell tumor of the right proximal femur that developed malignant change following surgical treatment ("secondary" malignant giant cell tumor) is presented. The patient had a cystic lesion that was initially interpreted as an aneurysmal bone cyst. A local recurrence six months later demonstrated the histological features of typical giant cell tumor. A further recurrence 22 months after the original treatment showed histological malignancy. Death was due to massive local recurrence and to extension of the malignancy to the pleura.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Zhu
authors.forename: G C
authors.initials: GC
authors.lastname: Steiner
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011859:Radiography