title: The effects of concurrent manipulations of cholinergic and noradrenergic systems on neocortical EEG and spatial learning.
abstract: In the spatial learning test, young animals were divided into three groups receiving saline, scopolamine (0.15 mg/kg), or scopolamine (0.8 mg/kg). Half of the animals in each group were lesioned with DSP-4 to destroy noradrenergic fibers. DSP-4 lesions did not produce any significant impairment alone or in combination with a lower dose of scopolamine (0.15 mg/kg), but they did further augment the scopolamine (0.8 mg/kg)-induced defect. In the electroencephalography (EEG) experiment, both control rats and DSP-4-lesioned rats were recorded after receiving saline, scopolamine (0.15 mg/kg), and scopolamine (0.8 mg/kg) injections. Scopolamine induced a dose- and behavioral state-dependent EEG slowing, whereas DSP-4 lesions did not change either baseline EEG activity or EEG reactivity to scopolamine.
authors.affiliation: Department of Neurology, University of Kuopio, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
authors.forename: J
authors.initials: J
authors.lastname: Sirviö
authors.forename: A
authors.initials: A
authors.lastname: Valjakka
authors.forename: A
authors.initials: A
authors.lastname: Pitkänen
authors.forename: J
authors.initials: J
authors.lastname: Partanen
authors.forename: P
authors.initials: P
authors.lastname: Riekkinen
mesh_terms: D000367:Age Factors; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004193:Discrimination Learning / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D009949:Orientation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology*
chemical_list: D001596:Benzylamines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D012601:Scopolamine; D002795:Choline O-Acetyltransferase; C012102:DSP 4