Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid.
Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.
Rabia
S A
SA
Department of Membrane Biochemistry and Neurochemistry, Hebrew University N Hadassah School of Medicine, Jerusalem, Israel.
Fibach
E
E
Kotler
M
M
Gatt
S
S
D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D007850:Lauric Acids / Q000494:pharmacology*; D014466:Ultraviolet Rays; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000528:radiation effects*
D007850:Lauric Acids; C040596:12-(1-pyrene)dodecanoic acid