Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
The involvement of the NMDA receptor in spontaneous non-convulsive epilepsy was studied by intracerebroventricular injections of APH and NMDA in WAG/Rij rats. The WAG/Rij rat strain is recognized as an animal model for human absence epilepsy. EEG registrations showed that APH (5 nmol/5 microliters; 25 nmol/5 microliters; 50 nmol/5 microliters) causes a dose-dependent decrease in the number and mean duration of the spike-wave discharges, while NMDA (50 pmol/5 microliters; 500 pmol/5 microliters; 5 nmol/5 microliters) induces a dose-dependent increase in the number. The effects of NMDA (5 nmol/5 microliters) can be blocked completely by APH (50 nmol/5 microliters). These results suggest an involvement of the NMDA receptor in experimental non-convulsive epilepsy, observed in the WAG/Rij model.
Peeters
B W
BW
Department of CNS Pharmacology, Organon International B.V., Oss, The Netherlands.
van Rijn
C M
CM
Vossen
J M
JM
Coenen
A M
AM
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D016202:N-Methylaspartate; D051381:Rats; D011922:Rats, Mutant Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000596:Amino Acids; D004338:Drug Combinations; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid