Cytochrome c oxidases: polypeptide composition, role of subunits, and location of active metal centers.
The general structure of the enzyme, its polypeptide composition, and a proposal for a rational nomenclature are discussed. The mitochondrially coded and bacterial cytochrome c oxidase subunits have been analyzed with more attention focused on elucidating the number of metals present in the enzyme and the ligands available for their coordination. The picture of a 2 Cu/2 Fe enzyme has been compared with that of a 3 Cu/2 Fe enzyme and a new model is proposed for the location of the metal centers in the enzyme.
Azzi
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Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
Müller
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D005075:Biological Evolution; D002417:Cattle; D003576:Electron Transport Complex IV / Q000032:analysis*; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis*; D009626:Terminology as Topic
D046911:Macromolecular Substances; D010455:Peptides; D003576:Electron Transport Complex IV