[Effects of estrogen treatment on the antiviral properties of murine Kupffer cells].
Adult female mice were administered 17 beta-oestradiol at pharmacological dosages by subcutaneous injections. Histopathological examination revealed an increase in cells of the mononuclear lineage infiltrating the sinusoids of the liver. In vitro culture of Kupffer cells demonstrated that the treatment did not alter their antiviral properties but did rather induce an activation of their non-specific immune properties. This activation might be beneficial or deleterious for the infected host and must be discussed in each particular pathological process.
Durquet-Perelmann
C
C
Laboratoire de Virologie de la Faculté de Médecine, Strasbourg, France.
Schmitt
C
C
Nonnenmacher
H
H
Braunwald
J
J
Bingen
A
A
Keller
F
F
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007376:Interleukin-2 / Q000096:biosynthesis; D007728:Kupffer Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D006517:Murine hepatitis virus / Q000187:drug effects; D012016:Reference Values; D014616:Vaccinia virus / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects
D004731:Endotoxins; D007376:Interleukin-2; D004958:Estradiol
Répercussions d'un traitement aux oestrogènes sur les propriétés antivirales des cellules de Kupffer murines.