How does the end begin? Formation and maintenance of telomeres in ciliates and yeast.
Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.
Zakian
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Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Runge
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Wang
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D000818:Animals; D001483:Base Sequence; D002875:Chromosomes; D015825:Chromosomes, Fungal; D004254:DNA Nucleotidyltransferases / Q000235:genetics; D004261:DNA Replication; D008969:Molecular Sequence Data; D012440:Saccharomyces / Q000235:genetics*; D013768:Tetrahymena / Q000235:genetics*
D004254:DNA Nucleotidyltransferases; C056773:telomere terminal transferase