[Changes in beta-adrenergic regulation of the cardiovascular system during aging].
Changes in beta-adrenergic regulation of the cardiovascular system in aging involved 40 healthy subjects aged 20-34, 60-74 and 75-89 have been studied. Single drug loads with propranolol (0.6 mg/kg, per os) and isadrin (10 mg, sublingually) were used. With aging, the beta-adrenergic regulation of heart at various levels (in the central and autonomic vegetative nervous system, the ACTH-cortisol system) changes. The negative effect of beta-adrenergic blockade on the cardiovascular system enhances, that is a result of a more significant suppression of the sympathetic effects on the heart and peculiarities of the propranolol pharmacokinetics in old age. The reactivity of beta-adrenergic mechanisms in response to their stimulation decreases as well. Blockade of the beta-adrenoreceptors produces a distinct saving effect on the performance of the cardio-respiratory system under conditions of physical loading, that is due to a suppression of sympathetic hyperactivity and elimination of excess strain in the ACTH-cortisol system at the peak submaximal physical loading.
Korkushko
O V
OV
Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000493:pharmacokinetics / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol
Izmeneniia beta-adrenergicheskoĭ reguliatsii serdechno-sosudistoĭ sistemy pri starenii.