[Aminobenzoic acid derivatives as specific inhibitors of cyclic nucleotide phosphodiesterase in the rat uterus].
It is shown, that p-aminobenzoic acid and its derivatives (p-acetylaminobenzoic acid and p-aminobenzoic acid hydrazide) in the concentration of 10(-6) M are the potent inhibitors (40% below the control specimens) of the phosphodiesterase activity of cyclic nucleotides in the soluble fraction of the adult rat uterus. These drugs exerted no action on the adenylate cyclase activity in membrane fractions. The inhibition is only specific to the uterus enzyme and is not revealed for other tissues. The inhibition is found to be of incompetitive character Ki for p-aminobenzoic acid hidrazide being equal to 3.2 microM.
Garnovskaia
M N
MN
Tret'iakov
A V
AV
Maslova
M N
MN
Etingof
R N
RN
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000037:antagonists & inhibitors*; D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*; D062366:para-Aminobenzoates
D000814:Aniline Compounds; D004965:Estrogen Antagonists; D062366:para-Aminobenzoates; C023730:Acedoben; D004958:Estradiol; C034343:4-aminobenzhydrazide; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010129:4-Aminobenzoic Acid
Proizvodnye aminobenzoĭnoĭ kisloty kak spetsificheskie ingibitory fosfodiésterazy tsiklicheskikh nukleotidov matki krys.