Receptor modification in the brains of spontaneously hypertensive and Wistar-Kyoto rats: regionally specific and selective increase in cerebellar beta 2-adrenoceptors.
Quantitative in vitro autoradiography was used to study beta-adrenergic and benzodiazepine receptor density in discrete regions from sagittal brain sections of 20 week old hypertensive (SHR) and normotensive (WKY) rats. The density of beta-adrenoceptors was increased by 68% in the granule cell layer of the cerebellum of the SHR without a change in receptor affinity; this increase was specific for receptors of the beta 2-subtype. On the other hand, benzodiazepine receptor density was unchanged in the cerebella of SHR. These results indicate that brain beta-adrenoceptors are differentially modulated by the hypertensive state which may be either a cause or a consequence of alterations in adrenergic nervous system activity found in the SHR.
Jones
C R
CR
Department of Research, Kantonsspital, Basel, Switzerland.
Palacios
J M
JM
Hoyer
D
D
Bühler
F R
FR
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D020120:Iodocyanopindolol; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D007093:Imidazoles; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C026777:ICI 118551; D020120:Iodocyanopindolol; D010869:Pindolol; C049763:CGP 20712A