title: Search for early lesions following human immunodeficiency virus type 1 infection. A study of six individuals who died a violent death after seroconversion.
abstract: Histologic studies supplemented by in situ hybridization for human immunodeficiency virus type 1 (HIV-1), Epstein-Barr virus, cytomegalovirus, and human herpesvirus type 6 were performed on tissues obtained from the autopsy of six patients who died either by homicide or suicide shortly after learning of their seroconversion. Except for mild nonspecific lymphoid tissue reactions, no lesions were noted that would indicate HIV-1 infection. DNA from all viruses was detected in some lymphoid cells. The amount of DNA for Epstein-Barr virus, cytomegalovirus, and human herpesvirus type 6 corresponded to that observed for clinically occult latent infection. Lymphoid cells carrying HIV-1 DNA were even less frequent. Cells positive for HIV-1 were noted in the lamina propria of the large intestine in three male homosexuals and in one female prostitute. The cells were arranged similar to antigen-presenting cells. The present findings are consistent with current theories regarding the pathogenesis of HIV-1-associated disease.
authors.affiliation: Department of Forensic Medicine, University of Cologne, West Germany.
authors.forename: B
authors.initials: B
authors.lastname: Madea
authors.forename: H J
authors.initials: HJ
authors.lastname: Roewert
authors.forename: G R
authors.initials: GR
authors.lastname: Krueger
authors.forename: D V
authors.initials: DV
authors.lastname: Ablashi
authors.forename: S F
authors.initials: SF
authors.lastname: Josephs
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification; D004064:Digestive System / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000382:microbiology / Q000473:pathology*; D006679:HIV Seropositivity / Q000382:microbiology / Q000473:pathology; D015497:HIV-1; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009693:Nucleic Acid Hybridization; D013154:Spleen / Q000473:pathology; D013997:Time Factors