Cutaneous toxicity of autologous bone marrow transplantation in nonseminomatous germ cell tumors.
High doses of carboplatin or cisplatin combined with cyclophosphamide and etoposide followed by autologous bone marrow transplantation (ABMT) rescue have been used in the treatment of testicular tumors that have had a bad prognosis. Unusual cutaneous complications, evoking radiation-induced dermatitis, have been seen in two of eight patients with the same regimen. This new type of toxicity seems to be related to high-dose combination chemotherapies. Good results in the treatment of patients with testicular tumors on relapse who continue to respond to chemotherapy lead to the extension of this type of schedule and cutaneous toxicity will probably develop.
Linassier
C
C
Oncology Unit, Centre Hospitalier Universitaire Bretonneau, Tours, France.
Colombat
P
P
Reisenleiter
M
M
Haillot
O
O
Chazard
M
M
Binet
C
C
Desbois
I
I
Lamagnere
J P
JP
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016190:Carboplatin; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003872:Dermatitis / Q000209:etiology*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000601:surgery*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000601:surgery*; D014182:Transplantation, Autologous
D009944:Organoplatinum Compounds; D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin