Reduced Free-Wilson approach applied to HSV-1 antiviral 7-amino-quinolines.
The antiviral activity of a series of 7-aminoquinolines was determined against herpes simplex virus type 1 (HSV-1), and quantitative structure-activity relationships were studied by using the reduced Free-Wilson model. The predictive model power was tested.
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Research Group for Pharmacochemistry, Faculty of Medicine, Karl Marx University, Leipzig.
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008954:Models, Biological; D018139:Simplexvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000634:Aminoquinolines; D000998:Antiviral Agents