title: Influence of oat bran on sucrose-induced blood pressure elevations in SHR.
abstract: To determine whether oat fiber influences BP, we gave spontaneously hypertensive rats (SHR) a diet high in sucrose and low in protein (calories: sucrose 52%, protein 15%, fat 33%) or a diet low in sucrose and high in protein (calories: sucrose 13%, protein 52%, fat 35%). The amount of fat in these particular diets has not been shown to influence BP, so we modified the 2 diets by replacing fat with oat bran (10% w/w). Accordingly, we examined 4 groups of 5 rats consuming different diets: high sucrose, high sucrose + oat bran, low sucrose, and low sucrose + oat bran. Not unexpectedly, SHR consuming the diet high in sucrose had a significantly higher BP after 2 weeks than those consuming the diet low in sucrose. The significant difference in BP continued over the next 3 weeks. At the end of 6 week duration of study, we found the following BP: SHR ingesting the high sucrose diet, 217 mm Hg +/- 5 (SEM) vs SHR consuming the low sucrose diet, 187 mm Hg +/- 4 (SEM) p less than .0001]. SHR eating the low sucrose diet and consuming supplemental bran showed no significant change in BP after 6 weeks compared to SHR eating the basic diet alone, 188 mm Hg +/- 6 (SEM); however, 5 SHR consuming the high sucrose diet with added oat bran showed a significantly lower BP 200 mm Hg +/- 2 (SEM) than SHR ingesting the basic high sucrose diet devoid of oat bran [p less than .01]. We conclude that addition of oat bran to the diet can ameliorate sucrose-induced BP elevations in SHR.
authors.affiliation: Department of Medicine, Georgetown University Medical Center, Washington, D.C. 20007.
authors.forename: M
authors.initials: M
authors.lastname: el Zein
authors.forename: J
authors.initials: J
authors.lastname: Areas
authors.forename: J
authors.initials: J
authors.lastname: Knapka
authors.forename: G
authors.initials: G
authors.lastname: Gleim
authors.forename: D
authors.initials: D
authors.lastname: DiPette
authors.forename: B
authors.initials: B
authors.lastname: Holland
authors.forename: H G
authors.initials: HG
authors.lastname: Preuss
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D001835:Body Weight; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D002523:Edible Grain; D009929:Organ Size; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D013395:Sucrose / Q000494:pharmacology*; D014556:Urine / Q000737:chemistry
chemical_list: D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D013395:Sucrose