Okadaic acid: a new probe for the study of cellular regulation.
The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.
Cohen
P
P
Department of Biochemistry, University of Dundee, UK.
Holmes
C F
CF
Tsukitani
Y
Y
D000818:Animals; D002273:Carcinogens; D002457:Cell Extracts; D002477:Cells / Q000187:drug effects; D003967:Diarrhea / Q000209:etiology; D004988:Ethers, Cyclic / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008387:Marine Toxins; D019319:Okadaic Acid; D010080:Oxazoles / Q000494:pharmacology / Q000633:toxicity; D010749:Phosphoprotein Phosphatases / Q000032:analysis / Q000037:antagonists & inhibitors; D010766:Phosphorylation; D057096:Shellfish Poisoning
D002273:Carcinogens; D002457:Cell Extracts; D004988:Ethers, Cyclic; D008387:Marine Toxins; D010080:Oxazoles; D019319:Okadaic Acid; C059041:calyculin A; D010749:Phosphoprotein Phosphatases