Cytomegalovirus infection among women attending a sexually transmitted disease clinic: association with clinical symptoms and other sexually transmitted diseases.
The prevalence rates of cytomegalovirus, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, and herpes simplex virus infection were determined for 247 women attending a sexually transmitted disease clinic in Halifax, Nova Scotia between July 1983 and December 1985. Isolation rates were 8.5%, 32.8%, 27.1%, 7.3%, and 6.5% for the five infectious agents, respectively. With multiple logistic regression analysis, the presence of cervical cytomegalovirus infection was independently associated with age less than 23 years and with gonococcal infection. Factors predictive of C. trachomatis infection included age less than 23 years, gonococcal infection, oral contraceptive use, and purulent discharge. Number of lifetime sexual partners was statistically associated only with herpes simplex virus infection. N. gonorrhoeae, C. trachomatis, and T. vaginalis were all independently associated with purulent discharge. Cytomegalovirus, N. gonorrhoeae, and C. trachomatis were statistically more likely to be present concurrently with other organisms than to be present as a single infection. Women with another genital infection were 6.5 times more likely to have cytomegalovirus than were women with no other genital infection. Of the 21 women with cytomegalovirus, only two had no other sexually transmitted disease. These findings suggest that N. gonorrhoeae and other sexually transmitted diseases may play a role in either the sexual transmission of or the reactivation of cervical cytomegalovirus infection.
Pereira
L H
LH
Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Embil
J A
JA
Haase
D A
DA
Manley
K M
KM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D002692:Chlamydia trachomatis; D003276:Contraceptives, Oral; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D006558:Herpes Genitalis / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009674:Nova Scotia / Q000453:epidemiology; D012044:Regression Analysis; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D014247:Trichomonas Vaginitis / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D002577:Uterine Cervical Diseases / Q000150:complications / Q000453:epidemiology* / Q000209:etiology
D003276:Contraceptives, Oral