title: Autocrine growth of leukemic cells.
abstract: Autocrine growth is a process whereby a cell both secretes and responds to a growth factor. This paper describes the stepwise malignant progression of leukemic cells which has been demonstrated in many experimental models of autocrine leukemic growth. In contrast, autocrine growth has not been proven as a major physiopathological mechanism for the growth of leukemic cells in vivo in human myeloid and lymphocytic leukemias. Growth-factor independency of human leukemic cell lines may be due to clonal selection.
authors.affiliation: INSERM U 268, Hôpital Paul Brousse, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Jasmin
authors.forename: V
authors.initials: V
authors.lastname: Georgoulias
authors.forename: F
authors.initials: F
authors.lastname: Smadja-Joffe
authors.forename: C
authors.initials: C
authors.lastname: Boucheix
authors.forename: C
authors.initials: C
authors.lastname: Le Bousse-Kerdiles
authors.forename: M
authors.initials: M
authors.lastname: Allouche
authors.forename: C
authors.initials: C
authors.lastname: Cibert
authors.forename: B
authors.initials: B
authors.lastname: Azzarone
mesh_terms: D002455:Cell Division; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000473:pathology* / Q000503:physiopathology; D008223:Lymphoma / Q000473:pathology; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000473:pathology
chemical_list: D006133:Growth Substances; D011956:Receptors, Cell Surface