title: [Nosogeography of hereditary and exogenous diseases of the nervous system among the populations of the territories in the upper Zaravshan river].
abstract: Medico-genetic, populational-genetic and clinico-genetic investigations were performed in upper Zeravshan river communities with population of 53,000. The investigation discovered a nonuniform nosologic spectrum of hereditary nervous diseases comprising a total of about 30 forms. An even distribution of hereditary diseases was found with a several degree of local accumulation of such forms as congenital femur dislocation, and surdomutism. Localities with especially high contents of ore deposits and increased underground water mineralization had higher incidence of severe hereditary disorders. Inbreeding and little migration were the major factors promoting the spread of hereditary disorders. Inbreeding coefficients was 0.0127 in the whole population with prevalence of cousin sibs wedlocks. The data allow one to create the regional registers of hereditary disorders taking into account the peculiarities of the population, and provide a more effective medico-genetic assistance to the region.
authors.forename: A M
authors.initials: AM
authors.lastname: Pulatov
authors.forename: T D
authors.initials: TD
authors.lastname: Pobedimskaia
authors.forename: O Ia
authors.initials: OIa
authors.lastname: Il'iabaev
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003241:Consanguinity; D005260:Female; D005618:Fresh Water; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000145:classification / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D010375:Pedigree; D012737:Sex Factors; D013620:Tajikistan; D014873:Water Pollutants / Q000009:adverse effects*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
chemical_list: D014873:Water Pollutants; D014874:Water Pollutants, Chemical
vernacular_title: Nozogeografiia nasledstvennykh i ekzogenno obuslovlennykh zabolevaniĭ nervnoĭ sistemy v populiatsiiakh verkhov'ev Zaravshana.