Selective opioid receptor antagonist effects upon intake of a high-fat diet in rats.
Short-term (2 h) intake of a high-fat diet in rats was significantly inhibited by intravenous (0.1-10 mg/kg: 39-67%) and central (1-5 micrograms, i.c.v.: 51%) naloxone. The irreversible mu opioid antagonist, beta-funaltrexamine (10 micrograms, i.c.v.: 37%), but not the irreversible mu 1 antagonist, naloxonazine (10 mg/kg, i.v.) inhibited intake, suggesting mu 2 receptor mediation. The delta antagonist, ICI 174864 (1-10 micrograms, i.c.v.: 41%) inhibited high-fat diet intake only at doses that also produced motor dysfunction.
Islam
A K
AK
Department of Psychology, Queens College, City University of New York, Flushing 11367.
Bodnar
R J
RJ
D000818:Animals; D004041:Dietary Fats / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009292:Narcotic Antagonists; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*
D004041:Dietary Fats; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009270:Naloxone; D009271:Naltrexone; C024524:beta-funaltrexamine