On the possible role of different endogenous opiate receptors in gastroduodenal ulceration of the rat.
In Wistar rats of both sexes stress(restraint)- and drug (indomethacin)-induced gastric, as well, as cysteamine-induced duodenal ulceration was treated by morphine and nalorphine, given either alone or in combination. Neither morphine nor nalorphine had a significant anti-ulcerogenic effect. In contrast, the combined morphine + nalorphine treatment showed a highly significant anti-ulcerogenic action in the case of gastric ulceration but it was ineffective on duodenal ulcer formation. It seems that the chi and sigma endogenous opiate receptors play a significant role in the anti-ulcerogenic effect, while the mu receptors are involved to a considerably lesser degree. Moreover, the experimental results strengthen the view that gastric and duodenal ulceration are two different pathological entities and that ulcer formation is only a common consequence.
Balint
G A
GA
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Nafradi
J
J
D000818:Animals; D003543:Cysteamine; D005260:Female; D007213:Indomethacin; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009269:Nalorphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D012149:Restraint, Physical
D011957:Receptors, Opioid; D009270:Naloxone; D003543:Cysteamine; D009020:Morphine; D009269:Nalorphine; D007213:Indomethacin