title: Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids.
abstract: A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagenase were examined. Both Z-Pro-Leu-Ala-NHOH and Z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC50 of 10(-6) M order.
authors.affiliation: Research Institute, Fuji Chemical Industries, Ltd., Toyama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Odake
authors.forename: T
authors.initials: T
authors.lastname: Okayama
authors.forename: M
authors.initials: M
authors.lastname: Obata
authors.forename: T
authors.initials: T
authors.lastname: Morikawa
authors.forename: S
authors.initials: S
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
mesh_terms: D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D009842:Oligopeptides; C064850:prolyl-leucyl-alanine hydroxamic acid; D003012:Microbial Collagenase