Serum creatine kinase-BB and small cell anaplastic carcinoma of the lung: two case reports.
Recent reports have suggested that serum creatine kinase isoenzyme BB (CK-BB) may be used as a tumor marker for a variety of malignancies, particularly prostatic carcinoma. Two cases of small cell anaplastic carcinoma of the lung (SCAC) had markedly contrasting levels of CK-BB by serum electrophoresis. Retrospective analysis of the index cases, and four additional autopsy cases of SCAC, included: 1) quantitation of CK-B in postmortem tumor and adjacent non-tumor lung tissue; 2) enzymatic and radioimmunoassay serum levels of CK-B; and 3) CK-B immunoperoxidase staining of tumor and non-tumor tissues for CK-B. Serum CK-BB is a non-specific tumor marker, but its presence, in whatever amount, should alert the clinician to the possibility of an associated malignancy, particularly SCAC or metastatic carcinoma.
Webb
T A
TA
Department of Pathology, Methodist Hospital, Peoria, Ill.
Dick
T T
TT
Blick
K E
KE
Sinn
C M
CM
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008175:Lung Neoplasms / Q000201:enzymology*
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase