title: Mechanism and evolution of the uncoupling protein of brown adipose tissue.
abstract: The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH(-)-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.
authors.affiliation: Institut für Physikalische Biochemie, Universität München, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Klingenberg
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002352:Carrier Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006878:Hydroxides; D007473:Ion Channels; D008565:Membrane Proteins / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011522:Protons; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D006878:Hydroxides; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011522:Protons; D000071256:Uncoupling Protein 1; C031356:hydroxide ion