title: Activation of iodine into a free-radical intermediate by superoxide: a physiologically significant step in the iodination of tyrosine.
abstract: A pivotal biochemical event in the thyroid physiology is identified unravelling a superoxide anion radical-mediated activation of iodine into an active I.- form, which could be the intermediate that is incorporated onto tyrosine. This active iodine species gives fairly stable spin-adducts with PBN that could be characterized using EPR spectroscopy. Thus, a long-lasting puzzle regarding the iodine intermediate formed before iodination of tyrosine seems to be solved.
authors.affiliation: School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India.
authors.forename: S
authors.initials: S
authors.lastname: Verma
authors.forename: G P
authors.initials: GP
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Laloraya
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D007455:Iodine / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D009589:Nitrogen Oxides; D010084:Oxidation-Reduction; D011817:Rabbits; D013113:Spin Labels; D013481:Superoxides / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D003497:Cyclic N-Oxides; D005609:Free Radicals; D009589:Nitrogen Oxides; D013113:Spin Labels; D013481:Superoxides; C029217:phenyl-N-tert-butylnitrone; D014443:Tyrosine; D007455:Iodine