[The morphology and clinical significance of pathologic changes of the adrenals and hypophysis in AIDS].
A semiquantitative morphometric technique (point counting) was applied to the pituitary and adrenals taken at necropsy from 130 AIDS patients (4 women, 126 men, mean age 39 [22-71] years) to ascertain the nature, extent and location of the pathological lesions. Abnormalities were found in 32% of the pituitaries and 76% of the adrenals. Only 17 patients had normal findings in both organs. The predominant lesions were due to opportunistic infections or infiltration by Kaposi's sarcoma or non-Hodgkin lymphoma. The commonest finding was necrotizing cytomegalovirus adrenalitis (n = 68); in one third of the cases this had caused severe destructive lesions involving over 50% of the parenchyma. The almost total destruction of the adrenals noted in some cases suggests that cytomegalovirus adrenalitis may run a progressive course; its clinical significance has hitherto been underestimated.
Groll
A
A
Abteilung für Pathologie III, Universität Frankfurt/Main.
Schneider
M
M
Althoff
P H
PH
Falkenbach
A
A
Helm
E B
EB
Keul
H G
HG
Schleiblinger
S
S
Hübner
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000307:Adrenal Gland Diseases / Q000150:complications / Q000473:pathology; D000311:Adrenal Glands / Q000473:pathology*; D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology; D005260:Female; D006652:Histological Techniques; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000150:complications / Q000473:pathology; D009336:Necrosis / Q000150:complications / Q000473:pathology; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology*; D014123:Toxoplasmosis / Q000150:complications / Q000473:pathology
Morphologie und klinische Bedeutung pathologischer Veränderungen an Nebennieren und Hypophyse bei AIDS.