title: Neutron radiotherapy in adenoidcystic carcinoma: preliminary experience at the Münster neutron facility.
abstract: In adenoidcystic carcinoma macroscopic residual disease after surgery, inoperable and recurrent tumors are characterized by relapse rates up to 70% if treated according to conventional treatment strategies including photon radiotherapy. By neutron therapy a tumor control rate of 70% has been reported. At the d,T-generator (14 MeV) in Münster nine patients with adenoidcystic carcinoma of the salivary glands in locally advanced stage have been treated since 1/86. A combined modality schedule (30 Gy photon/5 to 10 Gy neutrons) used in the beginning has been replaced by a definitive neutron therapy (15 Gy) with single fractions of 1.0 to 1.3 Gy in five to six weeks. Treatment planning included CT/MRI as well as computer assisted dose calculations based on a specific software for neutron therapy. The volume reduction by neutron radiotherapy was 82% for advanced disease. Continuous remission was achieved in seven of nine patients in a short follow-up period of medium 15 months (from six to 28 months). The two recurrences occurred at the field edge. Based on this preliminary experience and on a survey of the literature the main issues for neutron therapy in salivary glands tumors in particular adenoidcystic carcinomas are discussed: histology, stage, tumor size, location, surgery, treatment planning and delivery, dose, and side effects. A long term evaluation of neutron therapy within a controlled clinical multicenter trial is proposed.
authors.affiliation: Klinik für Strahlentherapie-Radioonkologie-der Westfälischen Wilhelms-Universität Münster, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Pötter
authors.forename: A
authors.initials: A
authors.lastname: Naszály
authors.forename: A
authors.initials: A
authors.lastname: Hemprich
authors.forename: U
authors.initials: U
authors.lastname: Haverkamp
authors.forename: C
authors.initials: C
authors.lastname: Al-Dandashi
authors.forename: K H
authors.initials: KH
authors.lastname: Höver
authors.forename: I
authors.initials: I
authors.lastname: Loncar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009502:Neutrons / Q000627:therapeutic use*; D011827:Radiation; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed