title: Coronavirus-like virions associated with a wasting syndrome in guinea pigs.
abstract: An apparent wasting syndrome was observed in newly arriving 3 to 4 week old guinea pigs characterized by anorexia, weight loss, diarrhea, perineal staining and death. Diagnostic efforts to attribute the disease to husbandry, environmental factors or to known guinea pig pathogens were unsuccessful. Clinical signs, enteric histopathological lesions and diagnostic transmission electron microscopy identification of typical coronavirus-like virions in fecal samples were consistent with enteric coronaviral diseases seen in other species.
authors.affiliation: United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010-5425.
authors.forename: G P
authors.initials: GP
authors.lastname: Jaax
authors.forename: N K
authors.initials: NK
authors.lastname: Jaax
authors.forename: J P
authors.initials: JP
authors.lastname: Petrali
authors.forename: K D
authors.initials: KD
authors.lastname: Corcoran
authors.forename: A P
authors.initials: AP
authors.lastname: Vogel
mesh_terms: D000818:Animals; D000855:Anorexia / Q000382:microbiology / Q000662:veterinary; D003332:Coronaviridae / Q000302:isolation & purification*; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D005243:Feces / Q000382:microbiology; D005260:Female; D006168:Guinea Pigs / Q000382:microbiology*; D007410:Intestinal Diseases / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D012008:Recurrence; D013577:Syndrome; D014771:Virion / Q000302:isolation & purification*; D015431:Weight Loss