title: Eosinophil and neutrophil production of leukotriene C4 and B4: comparison of cells from asthmatic subjects and healthy donors.
abstract: Production of LTC4 and LTB4 by eosinophils and neutrophils was compared between nine asymptomatic asthmatic subjects and eight healthy donors. We observed a statistically significant difference in LTC4 generated by eosinophils, but not LTB4 produced by neutrophils. These findings suggest a quantitative difference in eosinophils between asthmatic subjects and healthy donors.
authors.affiliation: First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: G
authors.initials: G
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Ohtsu
authors.forename: T
authors.initials: T
authors.lastname: Takishima
mesh_terms: D001249:Asthma / Q000378:metabolism / Q000473:pathology*; D002478:Cells, Cultured; D002845:Chromatography; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D009504:Neutrophils / Q000378:metabolism*; D012016:Reference Values; D013189:SRS-A / Q000096:biosynthesis*
chemical_list: D013189:SRS-A; D007975:Leukotriene B4