The molecular genetics of cancer. Introduction to principles of recombinant DNA technology.
There is now firm evidence that human cancers arise from derangements of a relatively restricted and well-defined set of genes. I summarize the principles one must master in order to understand the mechanisms by which these genes disrupt normal regulation of cell growth.
Benz
E J
EJ
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510-8056.
D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant / Q000096:biosynthesis; D005786:Gene Expression Regulation; D005821:Genetic Techniques; D006801:Humans; D009369:Neoplasms / Q000235:genetics*
D004274:DNA, Recombinant; D004262:DNA Restriction Enzymes