title: Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.
abstract: Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.
authors.affiliation: Laboratory of Herpesvirus Research, Food and Drug Administration, Bethesda, Maryland 20892.
authors.forename: J F
authors.initials: JF
authors.lastname: Manischewitz
authors.forename: G V
authors.initials: GV
authors.lastname: Quinnan
authors.forename: H C
authors.initials: HC
authors.lastname: Lane
authors.forename: A E
authors.initials: AE
authors.lastname: Wittek
mesh_terms: D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D004279:DNA, Viral / Q000096:biosynthesis; D004357:Drug Synergism; D017245:Foscarnet; D015774:Ganciclovir / Q000494:pharmacology*; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D004279:DNA, Viral; D017245:Foscarnet; D010746:Phosphonoacetic Acid; D015774:Ganciclovir