title: Activation of class I major histocompatibility complex gene expression by hepatitis B virus.
abstract: Normal hepatocytes express very few class I major histocompatibility complex (MHC I) molecules, but MHC I expression is elevated in hepatitis B virus (HBV) infection. We report here that hepatoblastoma cells with replicating HBV genomes express three- to fourfold-higher levels of MHC I protein and mRNA than do parent cells without HBV DNA. Transient transfection assays demonstrated that the HBV X protein trans activated transcription from an MHC I promoter and allowed identification of cis elements important for trans activation.
authors.affiliation: Department of Pathology, University of California School of Medicine, San Francisco 94143-0506.
authors.forename: D X
authors.initials: DX
authors.lastname: Zhou
authors.forename: A
authors.initials: A
authors.lastname: Taraboulos
authors.forename: J H
authors.initials: JH
authors.lastname: Ou
authors.forename: T S
authors.initials: TS
authors.lastname: Yen
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms; D008969:Molecular Sequence Data; D015533:Transcriptional Activation
chemical_list: D015395:Histocompatibility Antigens Class I; D015088:2',5'-Oligoadenylate Synthetase