Ki-67 and grading of malignant fibrous histiocytomas.
Although generally considered to be of high grade, malignant fibrous histiocytomas (MFH) show a range of histologic appearances and a diverse biologic behavior. More precise grading of this type of sarcoma is desirable. The rate of cell proliferation may reflect clinical behavior. A more sensitive measure of cell proliferation is the expression of the Ki-67 antigen. Frozen sections were prepared from 29 cases of MFH. Sections were immunohistochemically stained for Ki-67, and the results were quantitated by image analysis (CAS 100). The Spearman rank correlation test was used to compare the extent of the Ki-67 staining with the conventional histologic grade, nuclear grade, number of mitoses, extent of necrosis, and overall cellularity. There was a significant correlation between the extent of Ki-67 staining and the nuclear grade (cc = 0.56; P = 0.002) and overall histologic grade (correlation coefficient = 0.58; P = 0.001), but there was no significant, independent correlation between Ki-67 and prognosis.
Zehr
R J
RJ
Department of Orthopedic Surgery, Cleveland Clinic Foundation, Ohio 44195-5138.
Bauer
T W
TW
Marks
K E
KE
Weltevreden
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000378:metabolism; D000954:Antigens, Surface / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D019394:Ki-67 Antigen