title: Changes in the rate of production of superoxide anion in tails of Rana catesbeiana tadpoles during spontaneous and triiodothyronine-induced metamorphosis.
abstract: 1. The time course of changes in the rate of production of superoxide anion (O2) was compared with that of beta-glucuronidase in tails of Rana catesbeiana tadpoles during spontaneous and triiodothyronine (T3)-induced metamorphosis. 2. Superoxide production increases in tadpole tail tissue undergoing regression in vivo during spontaneous metamorphosis and in response to T3 treatment. 3. The specific activity of beta-glucuronidase rises three-fold relative to control levels in tadpoles treated with T3 in vivo. 4. The time of onset of the rise in beta-glucuronidase activity precedes the onset of tissue regression and the onset of the increase in superoxide production precedes the rise in beta-glucuronidase activity.
authors.affiliation: Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock 79430.
authors.forename: G H
authors.initials: GH
authors.lastname: Little
authors.forename: A
authors.initials: A
authors.lastname: Flores
mesh_terms: D000818:Animals; D005966:Glucuronidase / Q000378:metabolism; D008675:Metamorphosis, Biological / Q000187:drug effects*; D009132:Muscles / Q000378:metabolism; D011892:Rana catesbeiana / Q000254:growth & development*; D012016:Reference Values; D013481:Superoxides / Q000378:metabolism*; D013623:Tail / Q000254:growth & development; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D014284:Triiodothyronine; D013481:Superoxides; D005966:Glucuronidase