title: The putative cytoplasmic domain of the pseudorabies virus envelope protein gIII, the herpes simplex virus type 1 glycoprotein C homolog, is not required for normal export and localization.
abstract: Glycoprotein gIII of pseudorabies virus is a member of a conserved gene family found in at least seven diverse herpesviruses. We report here that the putative cytoplasmic domain of gIII is not required for transport to the cell surface and, unlike the prototype domain from herpes simplex virus type 1 glycoprotein C, is not required for stable membrane anchoring. Furthermore, this domain does not appear to be essential for incorporation of the glycoprotein into virions.
authors.affiliation: E. I. du Pont de Nemours & Co., Inc., Central Research and Development, Experimental Station, Wilmington, Delaware 19880-0328.
authors.forename: K A
authors.initials: KA
authors.lastname: Solomon
authors.forename: A K
authors.initials: AK
authors.lastname: Robbins
authors.forename: M E
authors.initials: ME
authors.lastname: Whealy
authors.forename: L W
authors.initials: LW
authors.lastname: Enquist
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D003001:Cloning, Molecular; D003593:Cytoplasm; D004252:DNA Mutational Analysis; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D008969:Molecular Sequence Data; D005810:Multigene Family; D011499:Protein Processing, Post-Translational; D015183:Restriction Mapping; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D008562:Membrane Glycoproteins; D014759:Viral Envelope Proteins