Inhibition of erythrocyte ghost ATPase by polyene antibiotics.
The effect of micromolar concentrations of polyene antibiotics on erythrocyte ghost ATPase activities has been studied. (Mg2+)-ATPase is inhibited by amphotericin B and amphotericin B methyl ester, whereas (Na+ + K+ + Mg2+)-ATPase is inhibited by amphotericin B and lucensomycin. (Ca2+ + Mg2+)-ATPase is only slightly affected by polyene antibiotics.
Capuozzo
E
E
Department of Biochemical Sciences, University of Rome, Italy.
Jullien
S
S
Salerno
C
C
Crifò
C
C
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000494:pharmacology*; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006801:Humans; D008155:Lucensomycin / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
C017501:methylamphotericin B; D008155:Lucensomycin; D000666:Amphotericin B; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase