title: Histological changes in glioblastoma after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon.
abstract: Seven glioblastomas were studied between 1 and 6 months after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon. Morphological study showed a great number of lymphocytes within the tumor tissue, and interactions between lymphocytes and glioblastoma cells, suggesting a killing phenomenon. These data support the potential usefulness of adoptive immunotherapy in patients with glioblastoma by means of intratumoral administration of activated lymphoid cells.
authors.affiliation: Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: S
authors.initials: S
authors.lastname: Coca
authors.forename: S
authors.initials: S
authors.lastname: Oya
authors.forename: R
authors.initials: R
authors.lastname: Martínez
authors.forename: C
authors.initials: C
authors.lastname: Regidor
authors.forename: L
authors.initials: L
authors.lastname: Barbolla
authors.forename: F G
authors.initials: FG
authors.lastname: Salazar
authors.forename: J
authors.initials: J
authors.lastname: Ramiro
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007267:Injections; D007370:Interferon Type I / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000473:pathology; D007694:Killer Cells, Natural / Q000473:pathology; D008214:Lymphocytes
chemical_list: D007370:Interferon Type I