Effect of the synthetic cannabinoid nabilone on spermatogenesis in mice.
Chronic treatment of mice with the synthetic cannabinoid nabilone (50 mg/kg, 3 times per week) reduced the number of pachytene spermatocytes. Nabilone did not affect other cell types in the testis or the sex organ weights. Nabilone tended to increase the number of abnormal spermatozoa, but this did not reach statistical significance. It is concluded that nabilone causes less testicular toxicity than the natural cannabinoids.
Patra
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PB
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland.
Wadsworth
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RM
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013090:Spermatocytes / Q000166:cytology; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
C011941:nabilone; D013759:Dronabinol