[Antiviral and interferon-inducing effect of fang-gan mixture].
The present study was carried out by using the plaque formation test, microdosage cytopathic effect (CPE) method, and mice nasal-cavity-attacking method to observe the antiviral and interferon-inducing effect of Fang-Gan mixture (FGM). The results showed that FGM has direct respiratory syncytia virus (RSV) inactivation effect, and protection effect after mice infected by RSV. FGM could also decrease mice death rate (P less than 0.01) in the experimentation of using parainfluenza virus to attack them, and work in coordination with interferon induced by Newcastle disease virus. After 8, 16, 24, 32 hours of injecting FGM into mice abdominal cavity, the authors used CPE method to determine interferon titer of L929 cells, and found that the highest interferon titer was 98.23 mu/m at the 24th hour. The interferon induced by FGM was in keeping with the nature of Type I interferon. The results suggested that FGM might have strong antiviral effect which is achieved by inducing interferon.
Ma
R
R
Nanjing College of TCM.
D000818:Animals; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007369:Interferon Inducers; D007370:Interferon Type I / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018184:Paramyxoviridae Infections / Q000188:drug therapy; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D007369:Interferon Inducers; D007370:Interferon Type I