title: Nucleolar organizer regions and Ki-67 immunostaining in ductal breast cancer: a comparative study.
abstract: 53 cases of invasive ductal (NOS) carcinomas of the breast were studied by means of an immunostaining method with Ki-67 monoclonal antibody and an argyrophilic method for the demonstration of Nucleolar Organizer Regions (AgNORs). The percentage of cancer cells with nuclear Ki-67 immunoreactivity and the mean number of NORs for each tumour were statistically related. The data obtained showed a good correlation between Ki-67 index and NOR score (rS = 0.47 - P less than 0.001). The authors suggest that the AgNOR method--which is applicable to routinely processed material--might effectively substitute Ki-67 immunostaining as a marker of cell proliferation in ductal breast cancer.
authors.affiliation: Istituto di statistica medica e biometria, Università di Genova.
authors.forename: M
authors.initials: M
authors.lastname: Canepa
authors.forename: C
authors.initials: C
authors.lastname: Gambini
authors.forename: A R
authors.initials: AR
authors.lastname: Sementa
authors.forename: L
authors.initials: L
authors.lastname: Borgiani
authors.forename: S
authors.initials: S
authors.lastname: Rovida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis / Q000473:pathology*; D002455:Cell Division; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009697:Nucleolus Organizer Region / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm