title: Tumor cell implantation with the use of Gelaspon gelatin sponge disc.
abstract: Myelomonocytic leukemia (My) mesoblastic nephroma (Ne) and hepatocellular carcinoma (He) cells were implanted under the renal capsule of F344, Long-Evans (LE) and BDIX rats. Gelaspon sponge discs were used in the implantation procedure, which were resorbed within a few days. The tumor cells, which were located on the surface of these discs could then attach themselves to the renal capsule and thus grow. There was a correlation between the number of tumor cells and the difference between the two kidney masses. The correlation was linear between 10(4) and 10(6) cells, thus the method proved to be a simple, fast and quantitative model in experimental cancer prevention and therapy.
authors.affiliation: Department of Hygiene and Epidemiology, University Medical School of Debrecen, DOTE, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Uzvolgyi
authors.forename: A
authors.initials: A
authors.lastname: Katona
authors.forename: P
authors.initials: P
authors.lastname: Kertai
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002452:Cell Count; D005260:Female; D005781:Gelatin Sponge, Absorbable; D007680:Kidney Neoplasms / Q000473:pathology; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008954:Models, Biological; D009368:Neoplasm Transplantation / Q000379:methods*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D009396:Wilms Tumor / Q000139:chemically induced
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene