title: Multicenter placebo-controlled study of nedocromil sodium 1% nasal solution in ragweed seasonal allergic rhinitis.
abstract: An 8-week double-blind study was carried out in 177 ragweed patients with seasonal allergic rhinitis to compare nedocromil sodium 1% nasal solution (Tilarin, QID, Fisons plc) and placebo. Symptoms of rhinitis were significantly reduced by nedocromil sodium during the peak 3-week pollen season (P = .001 for diary summary score) and the active treatment was rated effective by 74% of patients.
authors.affiliation: Division of Allergy and Immunology, St. Louis University Medical School, MO.
authors.forename: H M
authors.initials: HM
authors.lastname: Druce
authors.forename: S
authors.initials: S
authors.lastname: Goldstein
authors.forename: J
authors.initials: J
authors.lastname: Melamed
authors.forename: J
authors.initials: J
authors.lastname: Grossman
authors.forename: B A
authors.initials: BA
authors.lastname: Moss
authors.forename: R G
authors.initials: RG
authors.lastname: Townley
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002648:Child; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D017835:Nedocromil; D010919:Placebos; D011058:Pollen / Q000276:immunology*; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012996:Solutions
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D015363:Quinolones; D012996:Solutions; D017835:Nedocromil