Glycine enhances [3H]noradrenaline release from slices of rat hippocampus.
The effects of glycine on the release of [3H]noradrenaline ([3H]NA) have been investigated using rat hippocampus slices previously labeled with the radioactive catecholamine. Glycine (30-1000 microM) produced a potent and concentration-dependent increase of the release of [3H]NA evoked by 12 mM KCl. The effect of 1000 microM glycine was totally antagonized by 3 microM strychnine suggesting that, in rat hippocampus, glycine may regulate the release of NA by activating a receptor of the strychnine-sensitive subtype.
Raiteri
M
M
Istituto di Farmacologia e Farmacognosia, Università degli Studi di Genova, Italy.
Fedele
E
E
Fontana
G
G
Pittaluga
A
A
D000818:Animals; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium
D011956:Receptors, Cell Surface; D014316:Tritium; D011189:Potassium Chloride; D013331:Strychnine; D005998:Glycine; D009638:Norepinephrine