[The status of negative charge of the RBC and glomeruli and its relation to proteinuria in adriamycin nephrosis in rats].
The status of negative charge on RBC and glomeruli and its relation to proteinuria of adriamycin nephrosis in rats were studied by electron computerized picture analysis. The results showed that the negative charge (NC) on glomeruli decreased significantly at 48 hrs and 14 days after ADR injection although there was no proteinuria simultaneously. There was a positive relation between the changes of NC on glomeruli and those on RBC (r = 0.77, p less than 0.01), and there was negative relation between either of them and proteinuria respectively (r = -0.5140, p less than 0.05; r = -0.5231, p less than 0.01). The focal fusions of foot processes occurred prior to the onset of proteinuria.
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D000818:Animals; D000838:Anions / Q000378:metabolism; D004317:Doxorubicin / Q000009:adverse effects; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D007091:Image Processing, Computer-Assisted; D007678:Kidney Glomerulus / Q000378:metabolism*; D009401:Nephrosis / Q000139:chemically induced / Q000378:metabolism*; D011507:Proteinuria / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000838:Anions; D004317:Doxorubicin