title: Innovative techniques in radiation oncology. Clinical research programs to improve local and regional control in cancer.
abstract: There is a growing importance in failure analysis in cancer management. In these analyses locoregional failure as the cause of death emerges as a significant problem in many tumor sites, e.g., head and neck cancer, gynecologic cancer, genitourinary cancer. Because of these data, the radiation oncology community has attributed high priority to research efforts to improve locoregional control. These efforts include the following: (1) brachytherapy alone or with external beam radiation therapy or surgery; (2) intraoperative radiation therapy; (3) hyperthermia with radiation therapy; (4) particle irradiation (protons, neutrons, stripped nuclei, and pions); and (5) routes of administration of the treatment, including infusional (intravenous) chemotherapy with radiation therapy, intraarterial monoclonal antibodies with radionuclides, and intraarterial chemotherapy with radiation therapy. Each area of investigation is discussed.
authors.affiliation: Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
authors.forename: L W
authors.initials: LW
authors.lastname: Brady
authors.forename: A M
authors.initials: AM
authors.lastname: Markoe
authors.forename: B
authors.initials: B
authors.lastname: Micaily
authors.forename: S A
authors.initials: SA
authors.lastname: Fisher
authors.forename: F R
authors.initials: FR
authors.lastname: Lamm
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001918:Brachytherapy / Q000379:methods*; D003131:Combined Modality Therapy; D005214:Fast Neutrons; D006371:Helium; D006801:Humans; D006979:Hyperthermia, Induced; D007432:Intraoperative Period; D008495:Medical Oncology / Q000379:methods*; D009369:Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D011522:Protons; D016032:Randomized Controlled Trials as Topic; D014481:United States
chemical_list: D011522:Protons; D006371:Helium