title: [Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus].
abstract: The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous routes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.
authors.forename: Z V
authors.initials: ZV
authors.lastname: Shevtsova
authors.forename: R I
authors.initials: RI
authors.lastname: Krylova
authors.forename: N V
authors.initials: NV
authors.lastname: Doroshenko
authors.forename: I B
authors.initials: IB
authors.lastname: Lomovskaia
authors.forename: E G
authors.initials: EG
authors.lastname: Belova
authors.forename: G K
authors.initials: GK
authors.lastname: Zairov
authors.forename: Z N
authors.initials: ZN
authors.lastname: Dzhelieva
authors.forename: B A
authors.initials: BA
authors.lastname: Lapin
authors.forename: V M
authors.initials: VM
authors.lastname: Stakhanova
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D005243:Feces / Q000382:microbiology; D005260:Female; D006506:Hepatitis A / Q000276:immunology / Q000382:microbiology; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007275:Injections, Intravenous; D008099:Liver / Q000473:pathology; D008253:Macaca mulatta; D008297:Male
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D000410:Alanine Transaminase
vernacular_title: Eksperimental'naia model' gepatita A na makakakh rezusakh (Macaca mulatta), zarazhennykh virusom gepatita A cheloveka.