Use of ketamine-HC1 anesthesia in studies of chylomicron-triglyceride metabolism in the rat.
Ketamine with 10% acepromazine (Km/Ac) was evaluated for use in an investigation of plasma chylomicron-triglyceride clearance in rats. Clearance rate and the half-life of radiolabeled (14C) chylomicron triglycerides plus tissue uptake of 14C-fatty acids were equal in Km/Ac anesthetized and non-anesthetized rats. Km/Ac was found to be a suitable anesthesia in rats for the study of plasma chylomicron-triglyceride clearance.
Brown
C M
CM
Division of Foods and Nutrition, University of Illinois, Urbana-Champaign 61801.
Layman
D K
DK
D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002914:Chylomicrons / Q000097:blood* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006851:Hydrochloric Acid / Q000494:pharmacology; D007273:Injections, Intramuscular; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D002914:Chylomicrons; D005227:Fatty Acids; D014280:Triglycerides; D000075:Acepromazine; D007649:Ketamine; D006851:Hydrochloric Acid