[The effect of a low dose of ionizing radiation on the activity of cAMP-dependent phosphodiesterase and protein kinase of chicken thymus in ontogenesis].
Dynamics of changes in activities of cAMP-dependent enzymes, phosphodiesterase and protein kinase, were studied in the thymus of intact and irradiated, prior to incubation, (0.05 Gy) chicken embryos and chicks. The changes observed were wave-like. In determining phosphodiesterase activity of irradiated chicken thymocytes during ontogenesis the values were obtained that correlated with the cAMP level and adenylate cyclase activity. It was also shown that the increase in the rate of cAMP-dependent phosphorylation under the effect of low-level radiation corresponded to the cyclic nucleotide content of a cell at different development stages.
Khozhiakhmedov
G
G
Nishanbaev
K N
KN
Khamidov
D Kh
DKh
Dalimova
S N
SN
D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D000242:Cyclic AMP / Q000502:physiology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D013950:Thymus Gland / Q000196:embryology / Q000201:enzymology / Q000254:growth & development / Q000528:radiation effects*
D000242:Cyclic AMP; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases
Vliianie maloĭ dozy ioniziruiushchego izlucheniia na aktivnost' tsAMF-zavisimoĭ fosfodiésterazy i proteinkinazy timusa kur v ontogeneze.