Association of non-Hodgkin's lymphoma and hepatocellular carcinoma.
Four patients with hepatocellular carcinoma (HCC) out of a group of 132 with non-Hodgkin's lymphoma (NHL) are described. HCC was the most common second neoplasm in this series; in contrast, only 2 cases of HCC associated with NHL have been reported in the English literature. The diagnosis of HCC was suggested by ultrasound (US) and confirmed by ultrasonically guided fine-needle biopsy (UG-FNB). The 4 cases of HCC arose from cirrhosis. In this series, 10 out of 132 patients (7.6%) presented cirrhosis. Some considerations concerning the possible role of NHL (and/or the related therapy) in promoting the development of HCC in cirrhotic patients are discussed. The usefulness of US and of UG-FNB in the management of the patient with NHL is emphasized.
Di Stasi
M
M
I Divisione Medica, Ospedale Civile, Piacenza, Italy.
Cavanna
L
L
Fornari
F
F
Civardi
G
G
Rossi
S
S
Sbolli
G
G
Giacani
M
M
Fermi
S
S
Buscarini
L
L
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D014463:Ultrasonography