[Blood platelet alpha adrenergic receptors in congestive heart failure. Effects of ACE inhibition].
Platelet alpha-2-adrenergic receptor number and affinity were examined in 12 patients with class IV NYHA congestive heart failure (CHF) and 10 normal volunteers paired for age and sex. Platelet alpha-2-adrenergic receptor number is significantly decreased in CHF patients (178 +/- 18 fmol/mg prot. vs 282 +/- 21 fmol/mg prot. p less than 0.05). After Captopril treatment (6 weeks) alpha-2-receptor number increased but this increase was not statistically significant (236 +/- 28 fmol/mg prot.). This study supports the hypothesis that increased levels of circulating catecholamines in CHF lead to a decrease in platelet alpha-2-adrenoreceptors. Improved cardiac function following administration of Captopril could lead to a withdrawal of sympathetic tone. Captopril may also interact with sympathetic nervous function.
Radaelli
A
A
Istituto di Clinica medica I, Università, I.R.C.C.S., Policlinico S. Matteo, Pavia.
Caporotondi
A
A
Bongarzoni
A
A
Muggia
C
C
Manzinali
C
C
Marchesi
E
E
D000368:Aged; D001792:Blood Platelets; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D002216:Captopril
I recettori alfa adrenergici piastrinici nello scompenso cardiaco congestizio. Effetti dell'ACE-inibizione.