Effect of breast-feeding on oral rhesus rotavirus vaccine seroconversion: a metaanalysis.
The effect of concomitant breast-feeding on seroconversion following oral administration of rhesus rotavirus vaccine (RRV, serotype 3, strain MMU 18006) at 10(4) pfu was analyzed. Three studies were included, all randomized, double-blind trials involving a single dose of RRV to infants aged 2-5 months. None received concomitant oral polio vaccine. Seroconversion was measured by microneutralization or tube neutralization assay. The results show that 42 (48%) of 88 (95% confidence interval, 37%-58%) breast-fed babies seroconverted compared with 62 (70%) of 88 (95% confidence interval, 61%-80%) bottle-fed babies (chi 2 = 9.35, P less than .005). Thus, there was a significant adverse effect of breast-feeding with respect to RRV vaccine seroconversion.
Pichichero
M E
ME
University of Rochester Medical Center, New York 14642.
D000284:Administration, Oral; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001942:Breast Feeding; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D015201:Meta-Analysis as Topic; D009500:Neutralization Tests; D016032:Randomized Controlled Trials as Topic; D012401:Rotavirus / Q000276:immunology*; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; C052014:rhesus rotavirus vaccine