title: Processes of genome evolution reflected by base frequency differences among Serratia marcescens genes.
abstract: The G + C content of silent sites in codons varies greatly among Serratia marcescens genes; the value in any one gene seems to reflect a balance between mutation pressure towards high G + C content and natural selection constraining choice among synonymous codons. Interestingly, non-coding sequences have substantially lower G + C content than silent sites thought to be under little selective constraint.
authors.affiliation: Department of Genetics, Trinity College, Dublin, Ireland.
authors.forename: P M
authors.initials: PM
authors.lastname: Sharp
mesh_terms: D001482:Base Composition; D005075:Biological Evolution; D003062:Codon; D005798:Genes, Bacterial; D012706:Serratia marcescens / Q000235:genetics*
chemical_list: D003062:Codon