[Effect of glucagon on bile acid after hepatectomy in patients with hepatocellular carcinoma associated with cirrhosis].
Hepatic function frequently becomes worse, after hepatectomy in patients with hepatocellular carcinoma associated with cirrhosis. We usually use insulin and glucagon to treat patients with poor hepatic function, so we examined hepatic function in these patients in relation to bile acid metabolism. 1) Total serum bile acid levels were increased in patients with cirrhosis, and serum GCDCA, TCDCA values were especially high. After surgery, they rose even higher. 2) Glucagon was shown to stimulate C-AMP and decreased total serum bile acid, and especially serum GCDCA and TCDCA values.
Sudo
T
T
Second Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
Bessho
H
H
Miyamoto
M
M
Yasuda
C
C
Uchida
T
T
Kawamura
M
M
Kuyama
T
T
D001647:Bile Acids and Salts / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000601:surgery; D005934:Glucagon / Q000008:administration & dosage / Q000627:therapeutic use*; D006498:Hepatectomy; D006801:Humans; D007275:Injections, Intravenous; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000601:surgery; D011184:Postoperative Period
D001647:Bile Acids and Salts; D005934:Glucagon