Stimulation of oxygen consumption of platelets by Solcoseryl and cardiocrome during in vitro aging for 5 days.
Solcoseryl (SOL) and Cardiocrome (CAR) produced decreases in the partial oxygen pressure of platelet suspensions, indicating the acceleration of platelet oxygen consumption. However, the peak response to CAR was much faster than that to SOL. Application of 1 ml of SOL to 20 ml of platelet suspension stored for 1 day produced increases of 1 nmol ATP per min per 10(9) platelets. The same increases in oxygen consumption appeared after 3 or 5 day-storage.
Shimizu
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Research Division, Aichi Center, Japanese Red Cross Blood Transfusion Service, Japan.
D000183:Actihaemyl / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism*; D003574:Cytochrome c Group / Q000494:pharmacology*; D045304:Cytochromes c; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010101:Oxygen Consumption / Q000187:drug effects*; D013268:Stimulation, Chemical; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D013997:Time Factors
D003574:Cytochrome c Group; D004338:Drug Combinations; C017112:cytochrome C, flavin mononucleotide, thiamine pyrophosphate drug combination; D000183:Actihaemyl; D005486:Flavin Mononucleotide; D045304:Cytochromes c; D013835:Thiamine Pyrophosphate