[The neurotropic effects of hydrocortisone in surviving slices of the rat olfactory cortex].
The effects of hydrocortisone on short-term habituation, post-tetanic potentiation, fluctuations of the amplitude of focal potentials (FPs) and slow after-hyperpolarization were studied in the olfactory cortex slice preparations. Hydrocortisone (10(-5)-10(-4) M) inhibited the habituation but facilitated and prolonged the post-tetanic potentiation of the FPs. The hormone increased the fluctuations of the FPs and exerted no effect on slow after-hyperpolarization evoked by a brief orthodromic stimulation. The neurotrophic effects of the hydrocortisone seem to reflect adaptive reactions of nervous system under stress conditions.
Mokrushin
A A
AA
Bagaeva
T R
TR
Gerasimova
I A
IA
Emel'ianov
N A
NA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D046508:Culture Techniques; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009830:Olfactory Bulb / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D006854:Hydrocortisone
Neĭrotropnye éffekty gidrokortizona v perezhivaiushchikh srezakh oboniatel'noĭ kory mozga krys.