Studies on vaccination against papillomaviruses: a comparison of purified virus, tumour extract and transformed cells in prophylactic vaccination.
Calves were vaccinated with two preparations made from one cutaneous fibropapilloma induced by bovine papillomavirus type 2 (BPV-2). One vaccine consisted of homogenised tumour; the other contained purified virus only. Both produced resistance to a heavy challenge infection of BPV-2. One calf in the vaccinated group developed a small tumour and rejected it earlier than the control calves. It would appear likely that the prophylactic immune response was induced by viral structural proteins only and that tumour-specific antigens are unnecessary. Bovine fibroblasts were transformed in vitro by BPV-2 and administered as a vaccine; immunity was not induced.
Jarrett
W F
WF
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden.
O'Neil
B W
BW
Gaukroger
J M
JM
Laird
H M
HM
Smith
K T
KT
Campo
M S
MS
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000951:Antigens, Neoplasm / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D005347:Fibroblasts / Q000276:immunology*; D009500:Neutralization Tests; D010212:Papilloma / Q000276:immunology / Q000662:veterinary*; D027383:Papillomaviridae / Q000276:immunology* / Q000302:isolation & purification; D014020:Tissue Extracts / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000951:Antigens, Neoplasm; D014020:Tissue Extracts; D014765:Viral Vaccines