[Evaluation of the effectiveness and safety of Fragmin (Kabi 2165) versus calcium heparin in the prevention of deep venous thrombosis in general surgery].
Fourty patients who underwent general surgery have been enrolled in a double-blind controlled trial which evaluated the efficacy and safety of Fragmin, a new low molecular weight heparin, chosen to be the 1st OMS International Standard for LMWH. Fragmin 2500 UI anti-Xa once daily and unfractionated heparin 5000 UI twice daily were administered to prevent postoperative deep venous thrombosis. Prophylaxis began two hours before surgery and continued for the next 5 postoperative days. The incidence of isotopic venous thrombosis, thromboembolic disorders and bleeding complications have been evaluated. Results have shown a similar efficacy and safety profile of the two drugs, although Fragmin doses are markedly inferior to unfractionated heparin's. Moreover, Fragmin has the advantage of a single daily administration, with a better patients' compliance and an easier and less expensive nursing care.
Creperio
G
G
I Divisione Chirurgica, Ospedale Fatebenefratelli e Oftalmico (FBF), Milano.
Marabini
M
M
Ciocia
G
G
Bergonzi
M
M
Fincato
M
M
D000328:Adult; D004311:Double-Blind Method; D006493:Heparin / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D012307:Risk Factors; D013924:Thrombophlebitis / Q000517:prevention & control*
D006495:Heparin, Low-Molecular-Weight; C006871:calcium heparin; D006493:Heparin
Valutazione della efficacia e della tollerabilità di Fragmin (Kabi 2165) rispetto all'eparina calcica nella profilassi della trombosi venosa profonda in chirurgia generale.