Infection with adeno-associated virus type 5 inhibits mutagenicity of herpes simplex virus type 1 or 4-nitroquinoline-1-oxide.
Infection with adeno-associated virus type 5 (AAV-5) reduced the number of mutants arising in the hypoxanthine phosphoribosyltransferase locus of human RD 176 cells after infection with herpes simplex virus type 1 (HSV-1; partially inactivated) or 4-nitroquinoline-1-oxide (4-NQO). The mutation frequency was reduced by AAV-5 infection from 11.4 to 1.8 after mutation with HSV-1 and from 3.2 to 2.5 when mutation was induced by 4-NQO. This was analyzed by determination of the number of cells resistant to 8-azaguanine when infected with AAV-5 prior to induction of mutations with HSV-1 or 4-NQO.
Schlehofer
J R
JR
Deutsches Krebsforschungszentrum, Heidelberg, F.R.G.
Heilbronn
R
R
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity*; D001375:Azaguanine / Q000494:pharmacology; D000229:Dependovirus / Q000502:physiology*; D004351:Drug Resistance; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics* / Q000378:metabolism; D009152:Mutagenicity Tests; D009154:Mutation; D009600:Nitroquinolines / Q000633:toxicity*; D018139:Simplexvirus / Q000502:physiology*; D014407:Tumor Cells, Cultured; D014779:Virus Replication
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide; D007041:Hypoxanthine Phosphoribosyltransferase; D001375:Azaguanine