D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.
In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.
Watson
G B
GB
CNS Diseases Research, G.D. Searle & Company St. Louis, MO 63198.
Bolanowski
M A
MA
Baganoff
M P
MP
Deppeler
C L
CL
Lanthorn
T H
TH
D000818:Animals; D003523:Cycloserine / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D011760:Pyrrolidinones / Q000494:pharmacology; D012333:RNA, Messenger; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D014982:Xenopus laevis
D011760:Pyrrolidinones; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D003523:Cycloserine; C001369:1-hydroxy-3-amino-2-pyrrolidone; D005998:Glycine