Platelet imipramine binding in children and adolescents with impulsive behavior.
The serotonergic system has been implicated in the regulation of impulsive aggressive behavior either toward oneself or others. Imipramine binding sites were measured in the platelets of 23 impulsive aggressive children. Subjects ratings of total behavior, externalizing behavior, hostility, and aggression, as measured by the Child Behavior Checklist, were inversely correlated with the platelet imipramine binding. These findings are consistent with previous studies that suggest that decreased serotonergic activity is associated with impulsive aggressive behavior.
Birmaher
B
B
Department of Child Psychiatry, New York State Psychiatric Institute, New York.
Stanley
M
M
Greenhill
L
L
Twomey
J
J
Gavrilescu
A
A
Rabinovich
H
H
D000293:Adolescent; D000374:Aggression / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D002648:Child; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D007175:Impulsive Behavior / Q000097:blood* / Q000523:psychology; D008297:Male; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine