title: Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.
abstract: The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.
authors.affiliation: Department of Microbiology, University of Western Australia, Nedlands.
authors.forename: A A
authors.initials: AA
authors.lastname: Scalzo
authors.forename: N A
authors.initials: NA
authors.lastname: Fitzgerald
authors.forename: A
authors.initials: A
authors.lastname: Simmons
authors.forename: A B
authors.initials: AB
authors.lastname: La Vista
authors.forename: G R
authors.initials: GR
authors.lastname: Shellam
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D003587:Cytomegalovirus / Q000276:immunology* / Q000502:physiology; D005260:Female; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011995:Recombination, Genetic; D013045:Species Specificity; D013154:Spleen / Q000276:immunology* / Q000382:microbiology; D014779:Virus Replication