title: The complete amino acid sequence of a post-synaptic neurotoxin isolated from the venom of the Australian death adder snake Acanthophis antarcticus.
abstract: 1. A lethal neurotoxin (acanthophin d) was isolated from the venom of the Australian death adder snake Acanthophis antarcticus. 2. Acanthophin d consisted of a single polypeptide chain of 74 amino acid residues cross-linked by five disulphide bridges. 3. The results of neurophysiological experiments on murine phrenic nerve hemi-diaphragm preparations were consistent with irreversible post-synaptic blockage of neuromuscular transmission by acanthophin d.
authors.affiliation: School of Chemistry, Macquarie University, NSW, Australia.
authors.forename: D D
authors.initials: DD
authors.lastname: Sheumack
authors.forename: I
authors.initials: I
authors.lastname: Spence
authors.forename: M I
authors.initials: MI
authors.lastname: Tyler
authors.forename: M E
authors.initials: ME
authors.lastname: Howden
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005591:Chemical Fractionation; D002918:Chymotrypsin; D004546:Elapid Venoms / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D008969:Molecular Sequence Data; D009469:Neuromuscular Junction / Q000187:drug effects; D009498:Neurotoxins / Q000302:isolation & purification; D010455:Peptides / Q000032:analysis; D009435:Synaptic Transmission / Q000187:drug effects; D014357:Trypsin
chemical_list: D000596:Amino Acids; D004546:Elapid Venoms; D009498:Neurotoxins; D010455:Peptides; C063835:acanthophin D; D002918:Chymotrypsin; D014357:Trypsin