title: [The protective effect of adsorbents against ochratoxin A in swine].
abstract: Adsorption of the mycotoxin ochratoxin A by activated charcoal, various bentonites (acid, alkaline, neutral), and hydrated sodium calcium aluminosilicate was tested in vitro as well as in feeding experiments with pigs. In vitro tests showed that the 1% addition of activated charcoal leads to complete adsorption of ochratoxin A from aqueous solutions. This effect was not influenced by pH-values ranging from 3-8. In contrast, adsorption by bentonite and hydrated sodium calcium aluminosilicate occurred primarily in the acid range (pH 3-4). Dietary addition of hydrated sodium calcium aluminosilicate (1%) and acid bentonite (1%, 10%) to ochratoxin A-contaminated feed (1.0 mg/kg) had no effect on the blood or tissue levels of the toxin in pigs. The addition of 1% activated charcoal caused a slight decrease of ochratoxin A in the blood, whereas a tenfold dosage resulted in a 50% to 80% reduction of ochratoxin A levels in both blood and tissue. Reduction of ochratoxin A absorption via the dietary administration of activated charcoal (5%) was confirmed in a 16 week feeding experiment. However, this experiment also showed the serum level of vitamin E to be lower than in the controls receiving adsorbent-free feed.
authors.affiliation: II. Medizinischen Tierklinik, Ludwig-Maximilians-Universität München.
authors.forename: G
authors.initials: G
authors.lastname: Plank
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Grünkemeier
authors.forename: S
authors.initials: S
authors.lastname: Fischer
authors.forename: B
authors.initials: B
authors.lastname: Gedek
authors.forename: H
authors.initials: H
authors.lastname: Berner
mesh_terms: D000042:Absorption; D000327:Adsorption; D000538:Aluminum Silicates; D000821:Animal Feed; D000818:Animals; D001546:Bentonite; D002606:Charcoal; D009793:Ochratoxins / Q000493:pharmacokinetics* / Q000506:poisoning; D011041:Poisoning / Q000517:prevention & control / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D017641:Zeolites
chemical_list: D000538:Aluminum Silicates; D009793:Ochratoxins; D001546:Bentonite; D017641:Zeolites; D002606:Charcoal; C025589:ochratoxin A
vernacular_title: Untersuchungen zur protektiven Wirkung von Adsorbentien gegenüber Ochratoxin A beim Schwein.