Acute hemarthrosis: a histological, biochemical, and biomechanical correlation of early effects on the anterior cruciate ligament in a rabbit model.
The early histological, biochemical, and biomechanical characteristics of the anterior cruciate ligament (ACL) were determined in a rabbit model of acute hemarthrosis. The ACLs of 19 rabbits were given seven consecutive daily knee injections of 2 ml of fresh autologous blood, and then compared to contralateral ACLs from control knees injected with 2 ml of lactated Ringer's solution daily for 7 days. The rabbits were then sacrificed. Synovial proliferation with iron deposition within synoviocytes was observed; however, the architecture of the ACL was maintained. Additionally, the total collagen content, collagenase activity, and biomechanical properties of the ACL were unaltered.
Ishizue
K K
KK
Division of Orthopaedics and Rehabilitation, University of California, San Diego, La Jolla 92093.
Lyon
R M
RM
Amiel
D
D
Woo
S L
SL
D000208:Acute Disease; D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D006395:Hemarthrosis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008023:Ligaments, Articular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism; D011817:Rabbits
D003094:Collagen; D003012:Microbial Collagenase