Comparative pathology of HPCD pigs infected with wild-type and ara-T-resistant strains of Aujeszky's disease virus.
Fourteen 1- to 4-week-old hysterectomy-produced and colostrum-deprived (HPCD) pigs were inoculated intranasally with wild-type and ara-T-resistant strains of Aujeszky's disease virus (ADV), and the pathological lesion induced by the two strains was compared. The wild-type strain (YS-81) led to high mortality, and the pigs developed multifocal necrosis throughout the body and encephalitis. In comparison, the ara-T-resistant strain (YS-81TR) of the virus killed only 1-week-old HPCD pigs inoculated with 10(6.0) PFU per ml of the virus and did not kill pigs more than 2-weeks of age. The latter revealed consistently severe pneumonitis on post-inoculation day (PID) 14. Results of the present study indicated that the ara-T-resistant strain of ADV was less virulent for HPCD pigs than the parental wild-type strain of ADV and that it was able to grow better in the lung than in any other tissue.
Narita
M
M
National Institute of Animal Health, Ibaraki, Japan.
Imada
T
T
Haritani
M
M
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents; D001087:Arabinonucleosides / Q000494:pharmacology*; D003126:Colostrum; D004352:Drug Resistance, Microbial; D005260:Female; D011558:Herpesvirus 1, Suid / Q000145:classification / Q000276:immunology / Q000502:physiology; D007044:Hysterectomy; D007150:Immunohistochemistry; D011557:Pseudorabies / Q000473:pathology* / Q000503:physiopathology; D013552:Swine; D013936:Thymidine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000956:Antigens, Viral; D000998:Antiviral Agents; D001087:Arabinonucleosides; C010032:thymine arabinoside; D013936:Thymidine