Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques.
Pregnant macaques were used as a natural model for maternal-infant transmission of SRV-2 retrovirus. Fifty-one pregnant females were placed into one of four virus/antibody groups. Nonviremic mothers produced 100% virus-negative offspring at birth. In contrast, viremic mothers produced offspring which were 17% virus-negative and 83% virus-positive at birth. SRV-2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS.
Tsai
C C
CC
Regional Primate Research Center, University of Washington, Seattle.
Follis
K E
KE
Snyder
K
K
Windsor
S
S
Thouless
M E
ME
Kuller
L
L
Morton
W R
WR
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D001724:Birth Weight; D005260:Female; D008254:Macaca nemestrina; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000382:microbiology; D015301:Retroviruses, Simian / Q000276:immunology / Q000302:isolation & purification; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology / Q000635:transmission*; D015996:Survival Rate; D014766:Viremia
D000914:Antibodies, Viral