title: [Chemotherapy with high-dose cisplatin in brain metastasis of lung cancers].
abstract: CDDP is one of the most active single drugs in non small cell lung carcinoma. High doses of 200 mg/m2 are well tolerated when fractionated doses are used over a period of 5 d. Twenty-four consecutive patients (male, age range 38-70 y) with brain metastasis of lung carcinoma were included in this study. The total dose of CDDP - 200 mg/m2 - was divided into 5 equal daily fractions, infused over 6 h. Parenteral hydratation commenced the night before therapy. Efficiency was assessed by means of CT scan 15-30 d after the last course of chemotherapy. Complete response was achieved if no lesion was found on the CT scan; partial deafness 2 cases, renal toxicity 1 case, severe myelotoxicity 2 cases. Efficiency: failure was observed in 17 cases, objective responses in 7 cases (2 cases without injection contrast in the tumor, 3 partial regressions, 2 complete regressions). Thirty per cent of patients in this study exhibited an objective response with low toxicity. CDDP seems to be very useful in cerebral metastasis of lung carcinoma.
authors.affiliation: Hôpital Sainte-Marguerite, Marseille, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Kleisbauer
authors.forename: J C
authors.initials: JC
authors.lastname: Guerin
authors.forename: A
authors.initials: A
authors.lastname: Arnaud
authors.forename: R
authors.initials: R
authors.lastname: Poirier
authors.forename: D
authors.initials: D
authors.lastname: Vesco
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018288:Carcinoma, Small Cell / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D002945:Cisplatin
vernacular_title: Chimiothérapie par cisplatine à forte dose dans les métastases cérébrales des cancers du poumon.