title: Lack of antinociceptive activity of sumatriptan in rodents.
abstract: The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.
authors.affiliation: Department of Neuropharmacology, Glaxo Group Research Ltd, Ware, Herts, UK.
authors.forename: M
authors.initials: M
authors.lastname: Skingle
authors.forename: P J
authors.initials: PJ
authors.lastname: Birch
authors.forename: G E
authors.initials: GE
authors.lastname: Leighton
authors.forename: P P
authors.initials: PP
authors.lastname: Humphrey
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*; D018170:Sumatriptan; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D007211:Indoles; D013449:Sulfonamides; D014662:Vasoconstrictor Agents; D018170:Sumatriptan