title: Treatment of experimental Coxsackie B-3 viral myocarditis with Astragalus membranaceus in mice.
abstract: A murine model system for observing the effect of Astragalus Membranaceus (AM) on experimental myocarditis caused by Coxsackie B-3 virus (CB3V) was developed in 4-week-old male BALB/C mice. Gross, histopathologic and ultrastructural examinations of the infected-AM treated group showed that the severity and involved area of the myocardial lesions became milder and smaller than those in the infected-NS treated mice. The total lesion area, and the total lesion area/total myocardial area examined (%) and virus titer in the former group were also smaller and lower than those in the latter group. The results suggest that AM is effective in the inhibition of Coxsackie B virus propagation and protection of myocardium in mouse myocarditis.
authors.affiliation: Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Shanghai Medical University.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Yang
authors.forename: P Y
authors.initials: PY
authors.lastname: Jin
authors.forename: Q
authors.initials: Q
authors.lastname: Guo
authors.forename: W Z
authors.initials: WZ
authors.lastname: Wu
authors.forename: S Y
authors.initials: SY
authors.lastname: Pu
authors.forename: H Z
authors.initials: HZ
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Yang
authors.forename: K Q
authors.initials: KQ
authors.lastname: Wang
authors.forename: J Y
authors.initials: JY
authors.lastname: Shi
authors.forename: Z X
authors.initials: ZX
authors.lastname: Gong
mesh_terms: D000818:Animals; D027885:Astragalus propinquus; D003384:Coxsackievirus Infections; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D029822:Enterovirus B, Human; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D004365:Drugs, Chinese Herbal