title: A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein.
abstract: The XJC13 strain of Junin virus (JV) and the mouse-attenuated mutant C167 showed different GP38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycoprotein alteration and JV virulence in neonatal mice is proposed.
authors.affiliation: Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
authors.forename: L A
authors.initials: LA
authors.lastname: Scolaro
authors.forename: S E
authors.initials: SE
authors.lastname: Mersich
authors.forename: E B
authors.initials: EB
authors.lastname: Damonte
mesh_terms: D000818:Animals; D001116:Arenaviridae / Q000235:genetics*; D006477:Arenaviruses, New World / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006023:Glycoproteins / Q000235:genetics; D051379:Mice; D009154:Mutation; D010449:Peptide Mapping; D014759:Viral Envelope Proteins / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
chemical_list: D006023:Glycoproteins; D014759:Viral Envelope Proteins