Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram.
Citalopram, a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor. The synthesis, purification, characterization, and determination of specific activity are described.
Dannals
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Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205-2179.
Ravert
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Wilson
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Wagner
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HN
D001921:Brain / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D015283:Citalopram; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D014179:Neurotransmitter Uptake Inhibitors; D012701:Serotonin; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D014179:Neurotransmitter Uptake Inhibitors; D015283:Citalopram; D012701:Serotonin