title: Report of a pilot study of intra-arterial injection of I-131 lipiodol for the treatment of hepatoma.
abstract: This pilot study in 10 hepatoma patients investigated the feasibility of using selective targeting of radioisotope (I-131) lipiodol in the treatment of hepatoma patients. Lipiodol is a contrast medium that selectively goes to hepatoma and remains there for a long period as compared with that in normal liver and other tissues. Lipiodol was labelled with I-131 and infused into the hepatoma via the hepatic artery. Selective targeting of I-131 to hepatoma was demonstrated with a radiation dose ratio (hepatoma to normal liver) of up to 25 to 1. The biodistribution data of I-131-lipiodol in this study also confirmed the selective targeting of the radioisotope (I-131) to the hepatoma. Tumor radiation dose up to 26,000 rads can be delivered by this method. The treatment results were encouraging. About 70% of hepatoma patients had response to the treatment with reduction of alpha-fetoprotein and decrease of hepatoma sizes. The overall median survival was 9 months (range 2-17 months). This treatment was simple, safe, effective, non-expensive and well tolerated by all patients without major side effects. The optimal dose, schedule, duration of this treatment are still under investigation.
authors.affiliation: Department of Surgery, Veterans General Hospital-Taipei, R.O.C.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lui
authors.forename: R S
authors.initials: RS
authors.lastname: Liu
authors.forename: J H
authors.initials: JH
authors.lastname: Chiang
authors.forename: J G
authors.initials: JG
authors.lastname: Lo
authors.forename: K H
authors.initials: KH
authors.lastname: Lai
authors.forename: K L
authors.initials: KL
authors.lastname: King
authors.forename: H C
authors.initials: HC
authors.lastname: Cheng
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wei
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes; D007459:Iodized Oil