Abolition of herpes simplex cytopathic effect after treatment with peroxidase generated hypothiocyanite.
HSV1 suspensions were pre-incubated in a lactoperoxidase thiocyanate oxidizing system before inoculation in MRC5 fibroblast cultures. This pre-treatment could either delay or even abolish the HSV1 cytopathic potentiality. The effect was found to be time-dependent.
Courtois
P
P
Laboratoire de Stomatologie, Université Libre de Bruxelles, Faculté de Medecine, Belgique.
van Beers
D
D
de Foor
M
M
Mandelbaum
I M
IM
Pourtois
M
M
D000998:Antiviral Agents; D002460:Cell Line; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D007784:Lactoperoxidase / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D013861:Thiocyanates / Q000494:pharmacology*; D013997:Time Factors
D000998:Antiviral Agents; D013861:Thiocyanates; C024553:sodium thiocyanate; D007784:Lactoperoxidase; C031760:thiocyanate