title: [The regulation of meiotic inhibition and reinitiation in mammalian oocytes].
abstract: Experimental data on the control of biochemical factors regulating the arrest and resumption of meiosis in mammalian oocytes are reviewed. Evidence is provided on the action of the central (luteinizing and follicle-stimulating hormones) and paracrine (purine, steroids, gonadocrinins, growth factors, etc.) factors in controlling these processes. It is shown that the microenvironment of the follicle displays both inhibitory and stimulatory actions on the oocyte maturation. The role of the maturation-promoting factor in the meiosis stimulation and in the process of transmitting somatic cells from G2-phase to mitosis is analysed. An attempt has been undertaken to show the analogy of the oocyte meiosis reinitiation and the stimulation of somatic cell proliferation. A possibility of the pleiotropic control in the induction of oocyte maturation in the mammalian ovaries is discussed.
authors.forename: O A
authors.initials: OA
authors.lastname: Vorob'eva
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology; D008540:Meiosis / Q000502:physiology; D009865:Oocytes / Q000166:cytology* / Q000502:physiology
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D002118:Calcium
vernacular_title: Reguliatsiia ingibirovaniia i reinitsiatsii meĭoza ootsitov mlekopitaiushchikh.