title: Cellular and molecular aspects of the renal effects of diuretic agents.
abstract: In the past few years, increased knowledge of the nature of transport proteins and their molecular regulation in the translocation of ions across kidney membranes has emerged. We are beginning to better understand the characteristics of the interaction of diuretics with these transport proteins. It is likely that this knowledge will permit further insight into nephron function regulation.
authors.affiliation: Department of Medicine, San Juan Veterans Administration Center, Puerto Rico.
authors.forename: M
authors.initials: M
authors.lastname: Martinez-Maldonado
authors.forename: H R
authors.initials: HR
authors.lastname: Cordova
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002256:Carbonic Anhydrases / Q000187:drug effects; D002352:Carrier Proteins / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects* / Q000502:physiology; D011955:Receptors, Drug / Q000187:drug effects; D012964:Sodium / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects; D049992:Sodium Chloride Symporters; D017923:Sodium-Hydrogen Exchangers; D028021:Sodium-Potassium-Chloride Symporters; D064486:Solute Carrier Family 12, Member 3; D013148:Spironolactone / Q000494:pharmacology; D027981:Symporters
chemical_list: D002352:Carrier Proteins; D004232:Diuretics; D011955:Receptors, Drug; C578874:SLC12A3 protein, human; D015222:Sodium Channels; D049992:Sodium Chloride Symporters; D017923:Sodium-Hydrogen Exchangers; D028021:Sodium-Potassium-Chloride Symporters; D064486:Solute Carrier Family 12, Member 3; D027981:Symporters; C064415:thiazide receptor; D013148:Spironolactone; D012964:Sodium; D002256:Carbonic Anhydrases