title: Systemic bone marrow disorders: characterization with proton chemical shift imaging.
abstract: In a prospective clinical study, 26 patients (22 with malignant lymphoma and 4 with myelofibrosis) and 9 healthy volunteers were examined by conventional magnetic resonance and proton chemical shift imaging (CSI; modified Dixon method). On the basis of the CSI data, a quantitative evaluation of the relative fat and water signal fractions in regions of interest of the femur, pelvis, and spine was performed. In 16 of 17 patients with biopsy-proven bone marrow disorders, CSI revealed a significant reduction in the fat fraction of the bone marrow relative to that of normal volunteers. The visual assessment could detect only 14 of the 17 pathological cases.
authors.affiliation: German Cancer Research Center, Institute of Radiology and Pathophysiology, Heidelberg.
authors.forename: F
authors.initials: F
authors.lastname: Gückel
authors.forename: G
authors.initials: G
authors.lastname: Brix
authors.forename: W
authors.initials: W
authors.lastname: Semmler
authors.forename: I
authors.initials: I
authors.lastname: Zuna
authors.forename: W
authors.initials: W
authors.lastname: Knauf
authors.forename: A D
authors.initials: AD
authors.lastname: Ho
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000175:diagnosis*; D011446:Prospective Studies; D011522:Protons
chemical_list: D011522:Protons