[Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide].
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization. The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only. The authors propose, that stress-protective action of DSIP is realized with the involvements of the hypothalamo-pituitary-adrenal gland system.
Iukhananov
R Iu
RIu
Rozhanets
V V
VV
Mikhaleva
I I
II
Maĭskiĭ
A I
AI
D000311:Adrenal Glands / Q000032:analysis* / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000032:analysis*; D007103:Immobilization; D007328:Insulin / Q000097:blood; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood
D007328:Insulin; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D003701:Delta Sleep-Inducing Peptide; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Analiz mekhanizma stressprotektivnogo deĭstviia peptida, indutsiruiushchego delta-fazu sna.