title: Blocking by anti-idiotypic antibodies of monoclonal antibody mediated protection in mice against encephalomyocarditis virus induced diabetes and lethal disease.
abstract: Monoclonal antibodies (MA) UM 21.1 and UM 21.2 protect mice against encephalomyocarditis virus (D-variant) induced diabetes and lethal disease. MA-mediated protection in vivo as well as neutralization in vitro could be specifically blocked by anti-idiotypic antibodies.
authors.affiliation: Eijkman-Winkler Laboratory for Medical Microbiology, Academic Hospital Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Vlaspolder
authors.forename: T A
authors.initials: TA
authors.lastname: Oosterlaken
authors.forename: M
authors.initials: M
authors.lastname: Harmsen
authors.forename: P W
authors.initials: PW
authors.lastname: van Dijk
authors.forename: H
authors.initials: H
authors.lastname: Kievit
authors.forename: C A
authors.initials: CA
authors.lastname: Kraaijeveld
authors.forename: H
authors.initials: H
authors.lastname: Snippe
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D004686:Encephalomyocarditis virus / Q000276:immunology; D004769:Enterovirus Infections / Q000276:immunology / Q000517:prevention & control*; D007109:Immunity; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D014765:Viral Vaccines