title: Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.
abstract: Proton nuclear magnetic resonance spectroscopy was used to determine relative binding constants for several arsenical-antidote adducts. It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied.
authors.affiliation: Biophysical Research Division, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
authors.forename: R J
authors.initials: RJ
authors.lastname: O'Connor
authors.forename: E L
authors.initials: EL
authors.lastname: McGown
authors.forename: K
authors.initials: K
authors.lastname: Dill
authors.forename: S F
authors.initials: SF
authors.lastname: Hallowell
mesh_terms: D000931:Antidotes / Q000737:chemistry*; D001152:Arsenicals / Q000737:chemistry*; D004112:Dimercaprol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents; D013237:Stereoisomerism; D004113:Succimer / Q000737:chemistry; D014494:Unithiol / Q000737:chemistry
chemical_list: D000931:Antidotes; D001152:Arsenicals; D012997:Solvents; D004112:Dimercaprol; C035965:lewisite; D014494:Unithiol; C053663:phenyldichloroarsine; D004113:Succimer