Interaction of angiotensin II and atrial natriuretic peptide in the human fetoplacental unit.
We have identified two classes of membrane receptor for atrial natriuretic peptide (KD (dissociation constant) 0.2, 70.1 nmol/L) and angiotensin II (KD 1.7 nmol/L, 15.2 nmol/L) in human fetoplacental vasculature. In addition, in the isolated perfused placenta atrial natriuretic peptide inhibited the vasoconstrictor action of angiotensin II. These findings suggest that atrial natriuretic factor may regulate fetoplacental blood flow.
McQueen
J
J
Medical Research Council Blood Pressure Unit, Western Infirmary, Scotland.
Jardine
A
A
Kingdom
J
J
Templeton
A
A
Whittle
M J
MJ
Connell
J M
JM
D000804:Angiotensin II / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D010477:Perfusion; D010920:Placenta / Q000098:blood supply*; D011945:Receptors, Angiotensin / Q000378:metabolism*; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor