title: [What happened to Zollinger-Ellison syndrome?].
abstract: Three Zollinger-Ellison syndrome patients were treated during the period January 1977 to June 1978. The first patient is in good health 11 years 3 months after a total gastrectomy as is the second patient, 11 year after the enucleation of a cephalo-pancreatic gastrinoma. However the third patient died from malignancy 5 years after a total gastrectomy and enucleation of a cephalo-pancreatic gastrinoma followed by therapeutic cycles with streptozotocin and 5-fluorouracil. The decline in the Zollinger-Ellison syndrome over the last ten years is examined and the type of surgical treatment is discussed. Total gastrectomy once advocated as the preferred treatment, is now reappraised because of the effectiveness of medical therapy in controlling ulcers and because of the frequent malignancy of pancreatic gastrinomas.
authors.affiliation: Cattedra di VII Patologia Speciale Chirurgica e Propedeutica Clinica, Policlinico Umberto I, Roma.
authors.forename: F
authors.initials: F
authors.lastname: Procacciante
authors.forename: P
authors.initials: P
authors.lastname: Picozzi
authors.forename: A
authors.initials: A
authors.lastname: Fantini
authors.forename: A
authors.initials: A
authors.lastname: Di Nardo
authors.forename: M
authors.initials: M
authors.lastname: Catani
authors.forename: F
authors.initials: F
authors.lastname: Romeo
authors.forename: C
authors.initials: C
authors.lastname: Montesani
authors.forename: G
authors.initials: G
authors.lastname: Ribotta
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D005755:Gastrins / Q000097:blood; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000473:pathology / Q000601:surgery
chemical_list: D005755:Gastrins
vernacular_title: Dove sono finite le sindromi di Zollinger-Ellison?