Increased beta 2-adrenoceptor number in peripheral sympathetic ganglia of spontaneously hypertensive rats.
We determined beta-adrenoceptor concentrations in sympathetic ganglia from adult Spontaneously Hypertensive Rats (SHR) and Wistar-Kyoto (WKY) control rats by quantitative autoradiography. Adjacent tissue sections were incubated with [125I]iodocyanopindolol, with or without excess of unlabeled (-)-propranolol, the beta 1-antagonist CGP 20712A or the beta 2-antagonist ICI 118,551. Most beta-adrenoceptors were of the beta 2-type. Their concentration was higher in the superior cervical and stellate ganglia of SHR when compared to normotensive WKY. Our results indicate that beta 2-adrenoceptor stimulation may be enhanced in sympathetic ganglia of SHR, and could play a role in the maintenance of their increased sympathetic activity.
Saavedra
J M
JM
Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892.
Pinto
J E
JE
Flügge
G
G
Torda
T
T
D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D008297:Male; D010525:Peripheral Nerves / Q000378:metabolism; D011412:Propanolamines / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011940:Receptor Aggregation; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013233:Stellate Ganglion
D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C026777:ICI 118551