title: A porcine rotavirus strain with dual VP7 serotype specificity.
abstract: Porcine rotavirus MDR-13, which on original isolation showed a two-way antigenic relationship with human rotavirus RV-3, shows VP7 relationships with serotype G5 as well as G3 viruses upon gene reassortment. Analysis of porcine MDR-13 and the MD-UK reassortant revealed marked nucleotide and amino acid similarity of VP7 genes of these viruses with those of both serotype G3 and G5 viruses. Evolution of such a strain, possibly by sequential mutations in the VP7 gene, is discussed.
authors.affiliation: School of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: H S
authors.initials: HS
authors.lastname: Nagesha
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: C P
authors.initials: CP
authors.lastname: Hum
authors.forename: I H
authors.initials: IH
authors.lastname: Holmes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D003429:Cross Reactions; D005814:Genes, Viral; D006801:Humans; D008969:Molecular Sequence Data; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping; D013552:Swine
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus