Inhibition of nociceptive responses of dorsal horn neurones in the cat spinal cord by ohmefentanyl, a preferring mu opioid receptor agonist [corrected].
An action of ohmefentanyl (OMF), a novel preferring mu opioid receptor agonist, on nociceptive response of the dorsal horn neurone, has been studied in the spinal cat. OMF (0.5-2 micrograms/kg, i.v.) produced a potent naloxone-reversible inhibition of firing of dorsal horn neurones in response to noxious heating of glabrous hindpaw or to impulses in C primary afferents. When ejected into the substantia gelatinosa, OMF produced a relatively selective inhibition of C response, but not A response to excitation of myelinated afferent fibres, of the dorsal horn neurone. An interaction between ohmefentanyl and mu opioid receptors is discussed.
Zhao
Z Q
ZQ
Shanghai Brain Research Institute, Chinese Academy of Sciences, People's Republic of China.
Yang
H Q
HQ
Zhang
K M
KM
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D009292:Narcotic Antagonists; D009619:Nociceptors / Q000187:drug effects*; D011957:Receptors, Opioid / Q000502:physiology*; D017450:Receptors, Opioid, mu; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; C037016:F 7302; D005283:Fentanyl