Effect of lithium chloride on spermatogenesis and testicular delta 5-3 beta, 17 beta-hydroxysteroid dehydrogenase activities in the 'antiserum to luteinizing hormone' treated toad (Bufo melanostictus).
Activities of delta 5-3 beta- and 17 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSD and 17 beta-HSD), Leydig cell nuclear area (LCNA) and spermatogenesis in the testis were observed after injection of lithium chloride in the 'antiserum to luteinizing hormone (LH)' treated toad. A significant decrease in the activities of steroidogenic enzymes, LCNA and spermatogenesis were noticed after the injections of 'antiserum to LH' to toads. Further decrease in the activities of the above parameters was observed in the lithium chloride--'antiserum to LH' treated toad. It is suggested that lithium chloride may inhibits testicular function without modulating the pituitary activity.
Ghosh
D
D
Department of Physiology, University Colleges of Science and Technology, Calcutta University, India.
Biswas
N M
NM
Chaudhuri
A
A
Ghosh
P K
PK
D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D002025:Bufonidae; D002712:Chlorides / Q000494:pharmacology*; D007106:Immune Sera; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D007986:Luteinizing Hormone / Q000276:immunology; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D002712:Chlorides; D007106:Immune Sera; D007986:Luteinizing Hormone; D008094:Lithium; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; D018021:Lithium Chloride