[The role of gamma-aminobutyric acid in the inhibiting action of emotional stress on the sexual activity of mice].
Experiments on male mice of A/He strain have shown that an increase in the level of gamma-aminobutyric acid (GABA) or emotional stress block an increase in the blood level of testosterone caused by the presence of a recipient female mouse. Under the conditions of sex activation the blockade of GABAA-receptors eliminates partially the inhibitory effect of emotional stress on androgen function of a single male or a micropopulation of animals. A conclusion is that the inhibitory effect of emotional stress on the blood level of testosterone during sex activation is achieved through the GABAergic mechanism by means of excitation, at least partially, of GABAA-receptors. The revealed mechanism can play an adaptive role in stress under natural conditions.
Naumenko
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EV
Serova
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LI
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011963:Receptors, GABA-A; D000625:Aminooxyacetic Acid; D013739:Testosterone; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Rol' gamma-aminomaslianoĭ kisloty v ingibiruiushchem deĭstvii émotsional'nogo stressa na polovuiu aktivnost' mysheĭ.