Search for "in vitro" antiviral activity of a new isoflavonic glycoside from Ulex europaeus.
Extracts from Ulex europaeus L. (Fabaceae) were tested for antiviral activity against HSV-1 and poliovirus. It was found that the n-butanolic extract significantly inhibited the replication of these viruses, as shown by inhibition of cytophathic effects and reduction of plaques; the extract has neither a prophylactic nor a virucidal activity. From this extract has been isolated and identified by chromatographic, chemical, and spectroscopic methods, the 5-O-methylgenistein 7-O-beta D-glucopyranoside. This isoflavonic glycoside has not been previously described and it is responsible at least partially for the antiviral activity.
De Rodriguez
D J
DJ
Laboratoire de Pharmacognosic et de Mycologie, Faculté de Pharmacie, Rennes, France.
Chulia
J
J
Simões
C M
CM
Amoros
M
M
Mariotte
A M
AM
Girre
L
L
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification*; D002478:Cells, Cultured; D005419:Flavonoids / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D017955:Poliovirus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D005419:Flavonoids; D005960:Glucosides; D006027:Glycosides; D007529:Isoflavones; C064383:7-O-beta-glucopyranosyl-4'-hydroxy-5-methoxyisoflavone