Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.
Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P less than 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain.
Janzen
L
L
University of Manitoba, Winnipeg, Canada.
Tourtellotte
W W
WW
Kanfer
J N
JN
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D000368:Aged; D000704:Analysis of Variance; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000201:enzymology* / Q000473:pathology; D009186:Myelin Sheath / Q000201:enzymology / Q000473:pathology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571337:CNP protein, human; C061931:glycerophosphocholine cholinephosphodiesterase