[Clinico-immunologic correlations and various characteristics of the lymphocyte receptors in hepatocerebral dystrophy].
Clinical and immunological studies were performed in 45 patients with HCD. A group of patients was investigated by conventional immunology tests. spontaneous and active rosette formation, theophylline test, immunofluorescent B-lymphocyte investigation, IgA, IgM, IgG and circulating immune complexes (IC) levels measurement. Monoclonal antibodies were used to count T- and B-lymphocytes, T-helpers and T-suppressors in another group. [3H]-spiroperidol binding to blood lymphocytes was studied in 28 patients. Immune indices were found to be related to the disease duration, degree of visceral deterioration and the duration of Cu-depleting drugs administration. After a prolonged treatment with D-Penicillamin or Cuprenil immune indices returned to normal levels while the count of theophylline-sensitive lymphocytes remained unchanged. The mechanisms of metabolic and immune interrelations in HCD are discussed.
Gannushkina
I V
IV
Zhirnova
I G
IG
Chlonkovska
A
A
Markova
E D
ED
Ivanova-Smolenskaia
I A
IA
Poleshchuk
V V
VV
Komel'kova
L V
LV
Katosova
R K
RK
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006527:Hepatolenticular Degeneration / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008231:Lymphopenia / Q000209:etiology; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D011971:Receptors, Immunologic
Kliniko-immunologicheskie sopostavleniia i nekotorye osobennosti retseptorov limfotsitov pri gepatotserebral'noĭ distrofii.