Superoxide scavenging activity of BG-104 before and after sonication--determined by ESR spin trapping method.
BG-104 is a compound of Chinese herbs which were treated with infrared ray-heating and brewed with microorganisms resulting in activation of actual principles contained in the herbs, and its effectiveness has been reported on various inflammatory disorders such as Behcet's disease, rheumatoid arthritis, bacterial infections and so on. In addition, it is noted as an effective agent to retard cancer progress. This report shows a superoxide scavenging activity of BG-104 using an ESR spin trapping method. For the measurement of superoxide scavenging activity, recombinant human superoxide dismutase is used as a standard. Superoxide scavenging activity of BG-104 increases in a dose-dependent manner and activity is significantly augmented by its sonication.
Pronai
L
L
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa-ken, Japan.
Arimori
S
S
Nakazawa
H
H
D003497:Cyclic N-Oxides / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D013010:Sonication; D013113:Spin Labels; D013481:Superoxides / Q000378:metabolism*
D003497:Cyclic N-Oxides; D004365:Drugs, Chinese Herbal; D013113:Spin Labels; D013481:Superoxides; C065720:BG 104; C017245:5,5-dimethyl-1-pyrroline-1-oxide