title: [Immunohistochemical detection of calmodulin. A contribution to the histogenetic classification of eccrine poroma and clear cell acanthoma].
abstract: In previous immunohistochemical studies calmodulin (CaM) was detected in the sweat duct. In further investigations we searched for CaM-reactivity in eccrine poromas and clear cell acanthomas. CaM was only detectable in whorl-like areas, so confirming the concept of a ductal origin of this tumor. CaM-reactivity was failing in both, intraepidermal and malignant eccrine poroma. Acanthomas with clear cell pattern failed to give uniform results, suggesting a heterogenous origin of clear cells in the tumours investigated.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Friedrich-Schiller-Universität Jena.
authors.forename: H
authors.initials: H
authors.lastname: Schaarschmidt
authors.forename: U
authors.initials: U
authors.lastname: Wollina
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002147:Calmodulin / Q000032:analysis*; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D002147:Calmodulin
vernacular_title: Immunhistochemischer Nachweis von Calmodulin. Ein Beitrag zur histogenetischen Einordnung von ekkrinen Poromen und Klarzellakanthomen.