Regulation of mineralocorticoid secretion by the superfused fetal monkey adrenal gland: lack of stimulation of aldosterone by ACTH.
The rhesus monkey fetal adrenal secretion of mineralocorticoids was studied in vitro. Superfusion of fetal adrenal minces (n = 6) demonstrated that the fetal adrenal secretes aldosterone as well as desoxycorticosterone, 18 hydroxydesoxy corticosterone, and 18 hydroxycorticosterone. Addition of 250 ng/ml ACTH to the superfusion medium did not result in stimulation of aldosterone, but did increase these other mineralocorticoids. These data indicate that aldosterone production is not readily stimulated by ACTH in the fetal rhesus monkey, although other steroids in the mineralocorticoid pathway are.
Seron-Ferre
M
M
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco 94143.
Biglieri
E G
EG
Jaffe
R B
RB
D015069:18-Hydroxycorticosterone / Q000378:metabolism; D015070:18-Hydroxydesoxycorticosterone / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D003900:Desoxycorticosterone / Q000378:metabolism; D005333:Fetus / Q000502:physiology*; D066298:In Vitro Techniques; D008253:Macaca mulatta; D008901:Mineralocorticoids / Q000378:metabolism*
D015070:18-Hydroxydesoxycorticosterone; D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D000324:Adrenocorticotropic Hormone