title: [Chronic, fatal, neonatally-acquired cytomegalovirus disease with hypereosinophilia and multiple organ involvement].
abstract: The case is reported of a boy who died at age four from perinatally acquired persistent cytomegalovirus (CMV) infection associated with hypereosinophilia. Although no primary immunodeficiency was found he developed chronic CMV infection of the lungs, liver, bones, kidneys and finally brain. The clinical picture was dominated for a long period by asthmatic attacks due to severe obstructive bronchopulmonary disease. The possible immunological background to CMV infection and the clinical significance of the associated hypereosinophilia are discussed.
authors.affiliation: Pädiatrische Klinik, Kinderspital Luzern.
authors.forename: G P
authors.initials: GP
authors.lastname: Ramelli
authors.forename: J O
authors.initials: JO
authors.lastname: Gebbers
authors.forename: O
authors.initials: O
authors.lastname: Tönz
mesh_terms: D002675:Child, Preschool; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology / Q000635:transmission; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008297:Male; D009102:Multiple Organ Failure
chemical_list: D007136:Immunoglobulins
vernacular_title: Chronische, letal verlaufende Zytomegalievirus-Erkrankung mit Hypereosinophilie und multiplem Organbefall nach neonataler Infektion.