Proconflict effect of ACTH1-24: interaction with benzodiazepines.
The intracerebroventricular injection of ACTH1-24 (0.1-10 micrograms) produced a dose-dependent decrease of punished licking periods in the conflict test in rats. The same treatment failed to modify unpunished behavior. A similar effect was produced by alpha-MSH (0.25-5 micrograms), whereas ACTH4-10 and ACTH11-24 were ineffective in doses up to 10 micrograms. The proconflict effect of ACTH1-24 was completely antagonized by diazepam (1.5 mg/kg IP) and partially by the benzodiazepine receptor antagonist Ro 15-1788 (5 mg/kg IP). The results are in line with a possible "anxiogenic" action of ACTH1-24.
Corda
M G
MG
Department of Experimental Biology, University of Cagliari, Italy.
Orlandi
M
M
Fratta
W
W
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D003220:Conflict, Psychological; D003366:Cosyntropin / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004597:Electroshock; D005442:Flumazenil / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000209:etiology / Q000523:psychology; D000521:alpha-MSH / Q000494:pharmacology
D010446:Peptide Fragments; D003366:Cosyntropin; D005442:Flumazenil; C034016:ACTH (11-24); D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D003975:Diazepam