title: Differences in luteinizing hormone release stimulated in rat anterior pituitary cells by leukotriene C4 and by gonadotropin-releasing hormone in vitro.
abstract: Continuous administration of leukotriene C4 (LTC4, 10(-10) M) to superfused rat anterior pituitary cells increased LH release for 40 min only, whereas in a parallel experiment gonadotropin-releasing hormone (GnRH, 10(-9) M) evoked a continuous increase in hormone secretion. In contrast to GnRH, LTC4 did not desensitize rat anterior pituitary cells. The secretory action resulting from the administration of LTC4 (10(-10) M) was abolished for 40 min after previous stimulation. The results documented the dual action of LTC4 on LH exocytosis.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology, Heidelberg, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Przylipiak
authors.forename: L
authors.initials: L
authors.lastname: Kiesel
authors.forename: M
authors.initials: M
authors.lastname: Przylipiak
authors.forename: B
authors.initials: B
authors.lastname: Runnebaum
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007986:Luteinizing Hormone / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D013189:SRS-A / Q000494:pharmacology*; D013268:Stimulation, Chemical
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D013189:SRS-A; D007986:Luteinizing Hormone