Measurement of renal blood flow by 131I-labelled sodium iodohippurate imaging in a rat model of herpes encephalitis.
Renal blood flow was assessed qualitatively over a 30 min period in a rat model of herpes encephalitis by extra-renal scintigraphic imaging following the injection of 131I-labelled sodium iodohippurate. No significant differences were observed for renal blood flow in either kidney between (or within) infected and control groups. Our data suggest that kidney function is not compromised in this animal model of encephalitis. The results are discussed in the context of the development of a non-invasive protocol for the in vivo diagnosis of herpes encephalitis.
Cleator
G M
GM
Department of Medical Microbiology, Medical School, University of Manchester, England.
Klapper
P E
PE
Lewis
A G
AG
Sharma
H L
HL
Smith
A M
AM
D000818:Animals; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006566:Herpesviridae Infections / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid