Is picolinic acid a glycine agonist at strychnine-sensitive receptors?
By means of unit recording and electrophoretic application, the effect of picolinic acid on feline spinal interneurons in situ was studied in comparison with glycine. Picolinic acid inhibited neuronal firing in 60% of neurons and in some cases the inhibitory actions were antagonized by strychnine. Inhibition of firing by glycine, which was also strychnine-sensitive, was reduced in case of concomitant administration of picolinic acid. These results suggest that picolinic acid might act as a glycine agonist at strychnine-sensitive receptors.
Tonohiro
T
T
Biological Research Laboratories, Sankyo Co., Tokyo, Japan.
Tanabe
M
M
Kaneko
T
T
Iwata
N
N
D000818:Animals; D002415:Cats; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D010848:Picolinic Acids / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology*
D010848:Picolinic Acids; D017981:Receptors, Neurotransmitter; D013331:Strychnine; C030614:picolinic acid; D005998:Glycine