[Activity of the enzymes of DNA metabolism in the blood of patients with breast cancer].
Age-related changes in the activity of thymidine- and adenosine-metabolizing enzymes were studied in healthy females and those with breast cancer aged 46-70 years. A significant increase in activity of thymidine kinase, adenosine deaminase and 5'-nucleotidase and a decrease in that of thymidine phosphorylase were registered in blood serum of breast cancer patients of all age brackets. Adenosine deaminase activity in blood serum and lymphocytes of breast cancer patients was found to significantly change after surgery. A direct correlation was established between pretreatment thymidine phosphorylase activity and histological type of tumor, on the one hand and results of chemotherapy, on the other. The applicability of enzyme level assay for evaluating response to pre- and postoperative medication was studied.
Borzenko
B G
BG
Gorbachev
A A
AA
Dumanskiĭ
Iu V
IuV
Shevchenko
V V
VV
Shepliakov
M N
MN
D015720:5'-Nucleotidase / Q000097:blood; D000230:Adenocarcinoma / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000097:blood; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D013936:Thymidine / Q000378:metabolism*; D013937:Thymidine Kinase / Q000097:blood; D013939:Thymidine Phosphorylase / Q000097:blood
D000970:Antineoplastic Agents; D013939:Thymidine Phosphorylase; D013937:Thymidine Kinase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000241:Adenosine; D013936:Thymidine
Aktivnost' fermentov metabolizma DNK v syvorotke krovi bol'nykh rakom molochnoĭ zhelezy.