Effects of low doses of alcohol on delta-9-tetrahydrocannabinol's effects in pregnant rats.
Pregnant rats were intubated with 50 mg/kg of delta-9-tetrahydrocannabinol (THC) or with THC plus alcohol to determine if a low dose of alcohol (1 g/kg) would significantly increase blood levels of THC. On the basis of this study, a second study was conducted in which pregnant rats were intubated with THC (50, 25 or 0 mg/kg) plus alcohol (2, 1 or 0 g/kg) from gestation day six to parturition. THC reduced birth weights but did not significantly affect litter size or passive avoidance learning. Alcohol did not have a significant effect on offspring birth weight nor did it interact with THC to affect offspring.
Abel
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EL
Department of Obstetrics and Gynecology, Wayne State University, C.S. Mott Center for Human Growth and Development, Detroit, Michigan 48201.
Subramanian
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MG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001724:Birth Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000097:blood / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006128:Growth / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D000431:Ethanol; D013759:Dronabinol