Evaluation of a HTLV-1 subunit vaccine in prevention of experimental STLV-I infection in Macaca nemestrina.
Pig-tailed macaques were vaccinated with a human T-cell lymphotropic virus type I (HTLV-I) subunit vaccine. Vaccinates and controls were challenged with simian T-cell lymphotropic virus type I (STLV-I)-infected cells. Vaccination yielded antibody responses to HTLV-I and STLV-I gag and env precursors. Controls developed HTLV-I and STLV-I antibody to gag and tax protein. Immunization produced syncytium inhibiting antibody and cellular cytotoxicity to virus-infected cells. Reverse transcriptase activity was present in control macaques only, implying that the subunit vaccine was protective against STLV-I infection.
Dezzutti
C S
CS
Department of Veterinary Pathobiology, Ohio State University, Columbus.
Frazier
D E
DE
Lafrado
L J
LJ
Olsen
R G
RG
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000920:Antibody-Dependent Cell Cytotoxicity; D000956:Antigens, Viral / Q000276:immunology; D015153:Blotting, Western; D002460:Cell Line; D015686:Gene Products, env / Q000276:immunology; D015683:Gene Products, gag / Q000276:immunology; D015726:Giant Cells; D015481:HTLV-I Antibodies / Q000096:biosynthesis; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D008254:Macaca nemestrina; D012192:Retroviridae Infections / Q000517:prevention & control*; D015303:Simian T-lymphotropic virus 1 / Q000276:immunology*; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015686:Gene Products, env; D015683:Gene Products, gag; D015481:HTLV-I Antibodies; D014765:Viral Vaccines