title: Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors.
abstract: Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had -X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with +12 and one with +12 and +10, and the fifth tumor, a fibrothecoma, had +4,+9,+12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Pejovic
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: B
authors.initials: B
authors.lastname: Elmfors
authors.forename: U M
authors.initials: UM
authors.lastname: Flodérus
authors.forename: S
authors.initials: S
authors.lastname: Furgyik
authors.forename: G
authors.initials: G
authors.lastname: Helm
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000232:Adenofibroma / Q000235:genetics / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002999:Clone Cells / Q000473:pathology; D003537:Cystadenoma / Q000235:genetics / Q000473:pathology; D005260:Female; D005350:Fibroma / Q000235:genetics / Q000473:pathology; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D013798:Thecoma / Q000235:genetics / Q000473:pathology; D014314:Trisomy