The retinoic acid receptors.
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA. These findings suggest that the retinoic acid receptors differentially contribute retinoic acid physiology.
de Thé
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Unité de Recombinaison et d'Expression Génétique (INSERM U163/CNRS UA 271), Institut Pasteur, Paris, France.
Tiollais
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Dejean
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D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000378:metabolism*
D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin