[Electrical activity of the visual cortex under conditions of altered monoamine levels in the brain of animals].
In experiments on 8 rabbits and 12 rats changes in electrograms of the visual cortex of alert animals were studied under photic stimulation in conditions of pharmacological action on monoamine (MA) brain systems. After injection of MA precursors (5-oxitriptophane and d, 1-dioxiphenylalanine) following phenomena were observed: a) decrease of the amplitude of the averaged evoked potentials to rhythmic photic stimuli (1-20 imp. sec.-1); b) an enhancement of fast (15-25 Hz) oscillations in the cortical spontaneous electrical activity and weakening and modification of the effects of the blockader of synthesis of MA-alpha-methyl-dioxiphenylalanine. Under light stimulation potentiation of MA precursors effects was observed in the frequency spectra of electrocorticograms. In the same conditions the specificity of action of cathecholamines precursor was revealed in the form of an increase of power of rhythms of 5-7 Hz and it; decrease in 2-3 Hz. Possible mechanisms of the revealed phenomena are discussed.
Vorob'ev
V V
VV
Gal'chenko
A A
AA
Deriugina
O N
ON
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004567:Electrodes, Implanted; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D010775:Photic Stimulation; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000502:physiology; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
D015306:Biogenic Monoamines; D002395:Catecholamines; D012701:Serotonin; D008750:Methyldopa; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan
Elektricheskaia aktivnost' zritel'noĭ kory v usloviiakh izmeneniia urovneĭ monoaminov v mozge zhivotnykh.