Cytologic and hormonal findings in a carcinoid tumor of the uterine cervix.
A carcinoid tumor of the cervix in a 40-year-old woman was studied by cytology, histology, electron microscopy, immunohistochemistry and hormonal analysis. The preoperative cytologic and histologic findings strongly suggested a carcinoid tumor of the cervix. The serum serotonin level was elevated; immunohistochemical studies demonstrated the presence of serotonin in the cytoplasm of the tumor cells. Following radical hysterectomy, the concentration of serotonin was measured in the excised tumor; it was about 20 times higher than the level seen in normal cervical tissue, confirming that the tumor was a serotonin-secreting carcinoid of the uterine cervix.
Hirahatake
K
K
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan.
Hareyama
H
H
Kure
R
R
Kawaguchi
I
I
Yamaguchi
J
J
Sakuragi
N
N
Fujimoto
S
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006729:Hormones, Ectopic / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D012701:Serotonin / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor; D006729:Hormones, Ectopic; D012701:Serotonin