[The role of the ductal system in the self-regulation of pancreatic secretion].
Stimulation of mechanoreceptors of pancreatic main duct's distal portion activated secretion of bicarbonates and depressed secretion of protein, including enzymes, in dogs. Their incretion is increased, at that. The action of novocain on the duct either decreased or abolished the effect of activation and depression of secretion of various types of pancreocytes: the producers of bicarbonates and enzymes. The pancreas secretion from its two ducts was studied, too. Their secret differed by amylo- and lipolytic activity. An increased of the pressure in the main duct was found both to alter the secretion in the area drained through a given duct and to affect the properties of the secret drained through additional duct. The 10 or 15 cm H2O pressure increased the secretion debit of amylase, lipase and proteinase whereas a higher pressure suppressed their secretion. Several contours of the pancreatic secretion self-regulation seem to exist including one spreading from the gland duct system to its glandulocytes. Probable mechanisms of this self-regulation are discussed.
Korot'ko
G F
GF
Khudoiarova
A G
AG
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010183:Pancreatic Ducts / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000737:chemistry / Q000187:drug effects; D011312:Pressure; D011343:Procaine / Q000494:pharmacology; D012633:Secretin / Q000494:pharmacology; D013997:Time Factors
D012633:Secretin; D011343:Procaine; D002766:Cholecystokinin
Rol' protokovoĭ sistemy v samoreguliatsii sekretsii podzheludochnoĭ zhelezy.