6-(3,4-Dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile inhibits poliovirus uncoating.
We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovirus uncoating was the target of its activity.
González
M E
ME
Centro de Biología Molecular (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Spain.
Almela
M J
MJ
Yacout
M
M
Carrasco
L
L
D000998:Antiviral Agents / Q000494:pharmacology*; D002213:Capsid / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D017955:Poliovirus / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D012367:RNA, Viral / Q000096:biosynthesis; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011725:Pyridines; D012367:RNA, Viral; D014764:Viral Proteins; C065260:6-(3,4-dichlorophenoxy)-3-(ethylthio)-2-pyridinecarbonitrile