Autoradiographic analysis of alpha 1-noradrenergic receptors in the human brain postmortem. Effect of suicide.
In vitro quantitative autoradiography of alpha 1-noradrenergic receptors, using tritiated prazosin as a ligand, was performed on 24 human brains postmortem. Twelve brains were obtained from suicide victims and 12 from matched controls. We found significant lower binding to alpha 1 receptors in several brain regions of the suicide group as compared with matched controls. This decrease in receptor density was evident in portions of the prefrontal cortex, as well as the temporal cortex and in the caudate nucleus. Age, sex, presence of alcohol, and time of death to autopsy did not affect prazosin binding, in our sample, as measured by autoradiography.
Gross-Isseroff
R
R
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Dillon
K A
KA
Fieldust
S J
SJ
Biegon
A
A
D000367:Age Factors; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D015536:Down-Regulation; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D012737:Sex Factors; D013405:Suicide; D013702:Temporal Lobe / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D011941:Receptors, Adrenergic; D014316:Tritium; D009638:Norepinephrine; D011224:Prazosin