[Neurotoxicity of intra-arterial cis-platinum (CDDP) in the locoregional treatment of diffuse liver metastasis of carcinoma of the colon and rectum].
Peripheral neurotoxicity of i.v. cisplatin (CDDP) at high cumulative dosage is well documented. On the contrary neurotoxicity of CDDP following intra-arterial administration is less known. Five patients with liver metastasis from colorectal carcinoma have been treated with intraarterial CDDP and i.v. 5-fluorouracil according to a trial of the National Registry on Implantable Devices (RNSI); in these patients a severe peripheral neurotoxicity has been observed since the fourth cycle of chemotherapy. In the present paper we report the electroneurographic changes observed immediately after chemotherapy and several months later. Clinical characteristics of neuropathy following i.a. CDDP are the following: preferentially localized at the distal extremities of the limbs, exclusively sensitive, not reversible.
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Divisione Chirurgia Generale, Regione Liguria, U.S.L. IV, Ospedale Civile, Albenga, Savona.
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D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology
D002945:Cisplatin
Neurotossicità del cis-platino (CDDP) intra-arterioso nel trattamento locoregionale delle metastasi epatiche diffuse da carcinoma del colon-retto.