The dihydropyridine-sensitive calcium channel of the skeletal muscle: biochemistry and structure.
The dihydropyridine-sensitive calcium channel of the rabbit skeletal muscle is the first voltage-gated calcium channel which has been purified and biochemically characterized. The alpha 1-subunit, a 165 kDa protein, of the purified dihydropyridine receptor contains all regulatory sites of a L-type calcium channel and the calcium conducting unit. The purpose of this review is to summarize and discuss recent findings on the structure and possible function of the skeletal muscle calcium channel subunits.
Nastainczyk
W
W
Institut für Medizinische Biochemie, Medizinische Fakultät, Universität des Saarlandes, Homburg, Federal Republic of Germany.
Ludwig
A
A
Hofmann
F
F
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004095:Dihydropyridines / Q000494:pharmacology; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000302:isolation & purification; D008970:Molecular Weight; D009132:Muscles / Q000502:physiology*
D015220:Calcium Channels; D004095:Dihydropyridines; D046911:Macromolecular Substances; D008565:Membrane Proteins