The complete amino acid sequence of a post-synaptic neurotoxin isolated from the venom of the Australian death adder snake Acanthophis antarcticus.
1. A lethal neurotoxin (acanthophin d) was isolated from the venom of the Australian death adder snake Acanthophis antarcticus. 2. Acanthophin d consisted of a single polypeptide chain of 74 amino acid residues cross-linked by five disulphide bridges. 3. The results of neurophysiological experiments on murine phrenic nerve hemi-diaphragm preparations were consistent with irreversible post-synaptic blockage of neuromuscular transmission by acanthophin d.
Sheumack
D D
DD
School of Chemistry, Macquarie University, NSW, Australia.
Spence
I
I
Tyler
M I
MI
Howden
M E
ME
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005591:Chemical Fractionation; D002918:Chymotrypsin; D004546:Elapid Venoms / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D008969:Molecular Sequence Data; D009469:Neuromuscular Junction / Q000187:drug effects; D009498:Neurotoxins / Q000302:isolation & purification; D010455:Peptides / Q000032:analysis; D009435:Synaptic Transmission / Q000187:drug effects; D014357:Trypsin
D000596:Amino Acids; D004546:Elapid Venoms; D009498:Neurotoxins; D010455:Peptides; C063835:acanthophin D; D002918:Chymotrypsin; D014357:Trypsin