A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein.
The XJC13 strain of Junin virus (JV) and the mouse-attenuated mutant C167 showed different GP38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycoprotein alteration and JV virulence in neonatal mice is proposed.
Scolaro
L A
LA
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Mersich
S E
SE
Damonte
E B
EB
D000818:Animals; D001116:Arenaviridae / Q000235:genetics*; D006477:Arenaviruses, New World / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006023:Glycoproteins / Q000235:genetics; D051379:Mice; D009154:Mutation; D010449:Peptide Mapping; D014759:Viral Envelope Proteins / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
D006023:Glycoproteins; D014759:Viral Envelope Proteins