New mixed disulfides of L-cysteine derivatives and of glutathione with diethyldithiocarbamic acid and 2-mercaptoethanesulfonic acid.
It is generally assumed that thiol anticarcinogens like disulfiram (DSF) or sodium 2-mercaptoethane-sulfonate (mesna) after in vivo administration react rapidly with serum protein sulfhydryl groups forming mixed disulfides. Different methods have been established for the synthesis of mixed disulfides between cysteine or glutathione and diethyldithiocarbamate (DDTC) or mesna in order to elucidate their chemical and biological effects. A short summary is given of pilot biochemical experiments carried out with two mixed disulfides.
Rajca
A
A
Institute of Organic Chemistry and Technology, Silesian Technical University, Gliwice, Poland.
Bertram
B
B
Eisenbarth
J
J
Wiessler
M
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003545:Cysteine / Q000031:analogs & derivatives*; D004220:Disulfides; D004050:Ditiocarb / Q000138:chemical synthesis; D005978:Glutathione / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000031:analogs & derivatives*; D015394:Molecular Structure
D000970:Antineoplastic Agents; D004220:Disulfides; D008623:Mercaptoethanol; D004050:Ditiocarb; D005978:Glutathione; D003545:Cysteine; D015080:Mesna