[The effect of the x-ray irradiation of rats on the NAD-pyrophosphorylase and poly(ADP-ribose)polymerase activities of brain nuclei and on the NAD content in nerve tissue].
A study was made of the influence of X-irradiation of rats with various doses on NAD-pyrophosphorylase and poly(ADP-ribose) polymerase activity of brain nuclei. It was shown that X-radiation was ineffective with regard to NAD-pyrophosphorylase activity of nuclei and increased their poly(ADP-ribose) polymerase activity. Stimulation of poly(ADP-ribose) polymerase activity of nuclei was a function of radiation dose and correlated with the decrease in the NAD content of nervous tissue. It was found that mainly nonhistone proteins were ADP-ribosylated in nuclei of both irradiated and nonirradiated rats.
Zaalishvili
T M
TM
Dzhaparidze
N Sh
NSh
Michilashvili
R D
RD
Margiani
D O
DO
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000528:radiation effects*; D001923:Brain Chemistry / Q000528:radiation effects; D002467:Cell Nucleus / Q000201:enzymology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D009243:NAD / Q000032:analysis / Q000528:radiation effects*; D009417:Nerve Tissue / Q000201:enzymology / Q000528:radiation effects*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000032:analysis / Q000528:radiation effects*; D009713:Nucleotidyltransferases / Q000528:radiation effects*; D011065:Poly(ADP-ribose) Polymerases / Q000032:analysis / Q000528:radiation effects*; D051381:Rats; D014916:Whole-Body Irradiation
D009243:NAD; D011065:Poly(ADP-ribose) Polymerases; D009713:Nucleotidyltransferases; D009612:Nicotinamide-Nucleotide Adenylyltransferase
Vliianie rentgenovskogo oblucheniia krys na NAD-pirofosforilaznuiu i poli(ADP-riboza)polimeraznuiu aktivnost' iader golovnogo mozga i na soderzhanie NAD v nervnoĭ tkani.