Fetal pituitary graft is capable of initiating hormone synthesis in median eminence removed adult rat.
Rathke's pouches of 12- and 13-day-old rat embryos were implanted beneath the kidney capsule of adult male rats subjected to the removal of median eminence or to sham-operation. Host animals were sacrificed 28 days after grafting and the implanted pituitaries were processed for immunohistological examination. ACTH, LH-beta, FSH-beta, TSH-beta, GH and PRL immunopositive cells could be observed in fetal grafts of all experimental groups. However, the number and staining intensity of different hormone containing cells largely varied and presumably depended on the hormonal state of host animals. The results indicate that undifferentiated fetal pituitary does not require hypothalamic hypophysiotrophic neurohormones for proliferation and cytodifferentiation and that its development might be modulated by circulating trophic hormones of host animals.
Nemeskéri
A
A
2nd Department of Anatomy, Semmelweis Medical University, Budapest, Hungary.
Sétáló
G
G
Kacsóh
B
B
Halász
B
B
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D013006:Growth Hormone / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D007150:Immunohistochemistry; D007986:Luteinizing Hormone / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D008473:Median Eminence / Q000502:physiology / Q000601:surgery*; D010902:Pituitary Gland / Q000196:embryology / Q000378:metabolism* / Q000637:transplantation; D011388:Prolactin / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone