Murine candidiasis: cell-mediated immune responses correlate directly with susceptibility and resistance to infection.
Cell-mediated immune responses were evaluated after immunization in two inbred mouse strains, CBA/H and BALB/c, that are respectively susceptible and resistant to infection with the yeast Candida albicans. Local immune responses, as measured by leucocytic infiltration into the draining lymph node, were similar; however, both delayed-type hypersensitivity responses and candida-specific lymphocyte proliferation in vitro were significantly stronger in the resistant strain. The response was controlled by genes mapping outside the major histocompatibility complex. A possible explanation for the down regulation of the immune response in CBA/H mice is discussed.
Ashman
R B
RB
Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D004198:Disease Susceptibility; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA
D000946:Antigens, Fungal