[The role of the terminal amino acids in the physiological activity of opioid peptides (lymph stimulation and vascular permeability)].
The inclusion of amino acids (tyrosine, arginine) into the end part of the peptide chain permits to produce new analogues stimulating the lymph microvessels of the rat mesentery and increasing the blood microvessels permeability.
Khugaeva
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D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects* / Q000502:physiology; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008196:Lymph / Q000187:drug effects* / Q000502:physiology; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology; D008297:Male; D008643:Mesentery / Q000098:blood supply; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000494:pharmacology*
D004723:Endorphins; D014443:Tyrosine; D004743:Enkephalin, Leucine; D001120:Arginine; D001920:Bradykinin
Rol' kontsevykh aminokislot v fiziologicheskoĭ aktivnosti opioidnykh peptidov (limfostimuliatsiia, sosudistaia pronitsaemost').