[Fragile sites of cultured peripheral blood lymphocyte chromosomes in patients with gestational trophoblastic tumor].
Chromosomal aberrations were studied on peripheral blood lymphocytes from 16 women with gestational trophoblastic tumor (GTT) before chemotherapy or radiotherapy and from 15 age-matched normal women. The chromosomal aberration rate of the patients (19.6%) was significantly higher than that of the normal women (7.0%). Successful G-banding site analysis revealed 241 breaks and gaps consistent with the common fragile sites. Among these fragile sites, there were 45 breaks and gaps at the same locations of some oncogenes. There was no significant differences of chromosome aberration rate (P greater than 0.05) between 11 patients with GTT who recovered after chemotherapy and 15 control women.
Xu
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Gynecologic and Obstetric Department, Second Affiliated Hospital, Harbin Medical University.
D002869:Chromosome Aberrations; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D008214:Lymphocytes; D009857:Oncogenes; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*