title: Antibody against EBV in CSF from HIV-1 and HTLV-I infected patients.
abstract: We have measured the levels of antibody (ab) against different Epstein-Barr virus (EBV) antigens in 10 AIDS patients, 7 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and 20 control subjects. We found comparable serum levels of anti-EBV ab between AIDS patients, HAM/TSP patients and control subjects. By contrast, anti-EBV ab were present in the large majority of CSF from AIDS patients (70%) and HAM/TSP patients (60%) but only in 15% of control group. Our results support a synergistic role of EBV in retroviral infections of the central nervous system.
authors.affiliation: Clinica Neurologica IV, Università di Milano.
authors.forename: G V
authors.initials: GV
authors.lastname: Martino
authors.forename: L M
authors.initials: LM
authors.lastname: Grimaldi
authors.forename: L
authors.initials: L
authors.lastname: Moiola
authors.forename: P
authors.initials: P
authors.lastname: Cichero
authors.forename: R
authors.initials: R
authors.lastname: Ieri
authors.forename: P A
authors.initials: PA
authors.lastname: Bonini
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D015497:HIV-1; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000134:cerebrospinal fluid* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral