title: An outbreak of human Semliki Forest virus infections in Central African Republic.
abstract: Semliki Forest (SF) virus was responsible for an outbreak of febrile illnesses in Bangui, Central African Republic (CAR), during October-December 1987. The virus was isolated at first from mosquitoes, mainly Aedes africanus, collected August-October in a gallery forest 100 km from Bangui. During October-December, 22 isolations of SF virus were made from serum samples collected from patients in Bangui presenting with fever, severe persistent headache, myalgia, arthralgia, and a convalescence marked by asthenia. During the same period, 8 SF virus isolates were obtained from mosquitoes collected in Bangui, mainly from Ae. aegypti. Europeans, particularly soldiers who had recently arrived from France, were affected. Antibodies to alphaviruses had been previously detected in a high proportion of resident human populations in CAR. We conclude that SF virus is a human pathogen.
authors.affiliation: Pasteur Institute, Bangui, Central African Republic.
authors.forename: C C
authors.initials: CC
authors.lastname: Mathiot
authors.forename: G
authors.initials: G
authors.lastname: Grimaud
authors.forename: P
authors.initials: P
authors.lastname: Garry
authors.forename: J C
authors.initials: JC
authors.lastname: Bouquety
authors.forename: A
authors.initials: A
authors.lastname: Mada
authors.forename: A M
authors.initials: AM
authors.lastname: Daguisy
authors.forename: A J
authors.initials: AJ
authors.lastname: Georges
mesh_terms: D000330:Aedes / Q000382:microbiology; D000818:Animals; D000833:Animals, Suckling; D002488:Central African Republic / Q000453:epidemiology; D002648:Child; D003588:Cytopathogenic Effect, Viral; D004196:Disease Outbreaks; D005455:Fluorescent Antibody Technique; D005602:France / Q000208:ethnology; D006801:Humans; D008297:Male; D051379:Mice; D008889:Military Personnel; D009500:Neutralization Tests; D012672:Semliki forest virus / Q000302:isolation & purification; D014036:Togaviridae Infections / Q000453:epidemiology*; D014709:Vero Cells