title: A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
abstract: The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.
authors.affiliation: Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
authors.forename: J M
authors.initials: JM
authors.lastname: Redondo
authors.forename: S
authors.initials: S
authors.lastname: Hata
authors.forename: C
authors.initials: C
authors.lastname: Brocklehurst
authors.forename: M S
authors.initials: MS
authors.lastname: Krangel
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004262:DNA Restriction Enzymes; D003850:Deoxyribonuclease I; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D015321:Gene Rearrangement; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism; D010957:Plasmids; D011401:Promoter Regions, Genetic / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D009687:Nuclear Proteins; D011948:Receptors, Antigen, T-Cell; D015500:Chloramphenicol O-Acetyltransferase; D004262:DNA Restriction Enzymes; D003850:Deoxyribonuclease I