Cytomegalovirus infections in thalassemic patients after bone marrow transplantation.
We report the incidence of cytomegalovirus (CMV) seroconversion, infections and mortality in 169 consecutive thalassemic patients transplanted in Pesaro. We observed a 44% incidence of early seroconversion and a 52% incidence of late seroconversion. No relationship was found between seroconversion and acute or chronic graft-versus-host disease (GVHD) or rejection. The donor status did not influence the incidence of seroconversion, GVHD and rejection. Only three patients died of CMV infection (1.7%); in each case CMV disease was the final cause of death in patients with severe acute GVHD.
Baronciani
D
D
Divisione ematologica e Centro trapianto di midollo osseo di Muraglia, Ospedale di Pesaro, Italy.
Angelucci
E
E
Lucarelli
G
G
Galimberti
M
M
Polchi
P
P
Durazzi
S M
SM
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D013789:Thalassemia / Q000150:complications / Q000601:surgery*; D065227:Transfusion Reaction
D000914:Antibodies, Viral