Inhibition of human cancer cell growth by periodate-oxidized 3-aminopyridine adenine dinucleotide phosphate.
1. Periodate-oxidized 3-aminopyridine-adenine dinucleotide phosphate inhibited the proliferation of oral epithelium cancer and breast cancer cell lines. 2. The fast growing less differentiated embryonic kidney cell was more affected by the reagent then the embryonic lung fibroblast cell. 3. Incorporation of [3H]leucine of the treated cancer cells was inhibited. Incorporation of [3H]uridine was increased. Incorporation of [3H]thymidine was first increased and then decreased. 4. Tumor malic enzyme activity was inhibited by the reagent; but the treated cells did not show any difference in malic enzyme or glucose-6-phosphate dehydrogenase levels.
Chang
G G
GG
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Li
J C
JC
Chen
J D
JD
Meng
C L
CL
Lin
T
T
D000227:Adenine Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007930:Leucine / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors; D010084:Oxidation-Reduction; D010504:Periodic Acid; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014529:Uridine / Q000378:metabolism
D000227:Adenine Nucleotides; D010504:Periodic Acid; C039995:3-aminopyridine-1,N(6)-ethenoadenine dinucleotide phosphate; D008291:Malate Dehydrogenase; D007930:Leucine; D013936:Thymidine; D014529:Uridine