Kidney complications in EMC virus-induced diabetes in conventional DBA/2 male mice.
Conventional DBA/2 male mice of about 9 weeks of age were inoculated by intraperitoneally injecting EMC virus M variant (10(4) TCID50/0.1 ml/animal) which is passaged in mice. The mice which tested positive for glycosuria and hyperglycemia were examined histopathologically 2 or 5 months after inoculation. The kidneys were examined for thickening of Bowman's capsule and the mesangial matrix. These changes were more clearly observable 5 months after inoculation than they were 2 months after inoculation.
Shichinohe
K
K
Department of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan.
Shimizu
M
M
Ishizaki
M
M
Asakawa
M
M
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000473:pathology*; D004686:Encephalomyocarditis virus; D007668:Kidney / Q000473:pathology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA