title: [Problems with long-term immunosuppression following organ transplantation].
abstract: Long-term immunosuppression is followed by an increase of malignancies (skin cancer, lymphomas and Kaposi's sarkoma). Among the infectious complications an incidence of bacteraemia up to 48% is found, a relative increase of infection with listeria and salmonella, and viruses from the herpes group. The major side effect of azathioprine is haematologic, whereas Cyclosporin A is nephrotoxic. Three classes of renal functional impairment by Cyclosporine are defined: 1. renal dysfunction, 2. acute nephrotoxicity and 3. chronic nephrotoxicity. Appropriate ways to handle chronic nephrotoxicity are discussed.
authors.affiliation: Departemente für Chirurgie, Medizin und Pathologie, Kantonsspital, Universität Basel.
authors.forename: G
authors.initials: G
authors.lastname: Thiel
authors.forename: J
authors.initials: J
authors.lastname: Landmann
authors.forename: M
authors.initials: M
authors.lastname: Mihatsch
mesh_terms: D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D009369:Neoplasms / Q000276:immunology*; D009894:Opportunistic Infections / Q000276:immunology*; D011379:Prognosis; D012307:Risk Factors; D014181:Transplantation Immunology / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents
vernacular_title: Probleme der Langzeit-Immunsuppression nach Organtransplantation.