title: Assay methods for cyclosporine monitoring following liver transplantation.
abstract: This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
authors.forename: M C
authors.initials: MC
authors.lastname: Haven
authors.forename: L M
authors.initials: LM
authors.lastname: Sobeski
authors.forename: R A
authors.initials: RA
authors.lastname: Earl
authors.forename: R S
authors.initials: RS
authors.lastname: Markin
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003524:Cyclosporins / Q000097:blood*; D005069:Evaluation Studies as Topic; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D016031:Liver Transplantation / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods
chemical_list: D003524:Cyclosporins