title: Active transport of proteins into the nucleus.
abstract: Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is a highly selective process that can be divided into two steps, receptor-binding followed by translocation through the nuclear envelope. Receptor-binding is mediated by nuclear localization signals that have been identified in many nuclear proteins. Translocation is energy-dependent and occurs through the nuclear pore complex.
authors.affiliation: Department of Biochemistry, University of Basel, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Wagner
authors.forename: J
authors.initials: J
authors.lastname: Kunz
authors.forename: A
authors.initials: A
authors.lastname: Koller
authors.forename: M N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001693:Biological Transport, Active; D002451:Cell Compartmentation; D008969:Molecular Sequence Data; D009685:Nuclear Envelope / Q000378:metabolism* / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D009687:Nuclear Proteins; D011956:Receptors, Cell Surface