title: Disinhibition in the monkey prefrontal cortex, by injecting bicuculline, induces forelimb movements learned in a GO/NO-GO task.
abstract: Local injection of a GABA (gamma-aminobutyric acid) antagonist, bicuculline, into Brodmann's area 8 (Walker's areas 8A and 45) of the monkey prefrontal cortex induced movements of the contralateral forelimb in 4 monkeys that were well-trained to perform a two-choice visual discrimination GO/NO-GO task by appropriate release of the hand from a lever. But the same procedures of injection in two naive monkeys did not. These results indicate that, during learning of the task, a new structure responsible for learned movement of the forelimb was made in area 8 and was disinhibited by bicuculline and, furthermore, they suggest that inhibitory GABA neurons suppress tonically efferent neurons associated with the initiation of movement.
authors.affiliation: Department of Neurophysiology, Kyoto University, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oishi
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D005123:Eye; D005552:Forelimb / Q000502:physiology*; D007267:Injections; D008253:Macaca mulatta; D008297:Male; D009068:Movement / Q000187:drug effects / Q000502:physiology*; D012782:Shoulder
chemical_list: D001640:Bicuculline