title: Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain.
abstract: The signals required for rapid internalization of the bovine cation-dependent mannose 6-phosphate receptor have been localized to two distinct regions of the 67-amino acid cytoplasmic domain. One signal includes phenylalanine 13 and phenylalanine 18, while the other involves tyrosine 45. The former signal is more potent than the latter, but both must be present for the maximal rate of receptor internalization. Each signal shares similarities with the known internalization signals of other recycling receptors.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: K F
authors.initials: KF
authors.lastname: Johnson
authors.forename: W
authors.initials: W
authors.lastname: Chan
authors.forename: S
authors.initials: S
authors.lastname: Kornfeld
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002412:Cations; D002462:Cell Membrane / Q000378:metabolism; D002872:Chromosome Deletion; D003593:Cytoplasm / Q000378:metabolism; D004705:Endocytosis; D007700:Kinetics; D007739:L Cells / Q000378:metabolism; D008360:Mannosephosphates / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D010649:Phenylalanine; D010957:Plasmids; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D014162:Transfection; D014443:Tyrosine
chemical_list: D002412:Cations; D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface; D014443:Tyrosine; D010649:Phenylalanine