[Mechanisms of the protective action of sulfur-containing radioprotectors on the intestinal epithelium].
In studying the influence of cystamine and gammaphos on the recovery of mouse jejunum epithelium after irradiation with doses inducing intestinal form of acute radiation sickness, it was shown that the radioprotective agents did not influence D0 value for intestinal epithelium stem cells, but in crypts the number of DNA-synthesizing enterocytes that entered mitosis increased after the preventive administration of the radioprotectors. All this caused the number of cells per villus to increase and intestinal mucosa to recover more readily.
Vladimirov
V G
VG
Grigor'eva
E V
EV
D004999:Amifostine / Q000627:therapeutic use; D000818:Animals; D003037:Cobalt Radioisotopes; D003538:Cystamine / Q000627:therapeutic use; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000187:drug effects / Q000528:radiation effects*; D007583:Jejunum / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D004999:Amifostine; D003538:Cystamine
Mekhanizmy zashchitnogo deĭstviia serosoderzhashchikh radioprotektorov na kishechnyĭ épiteliĭ.