title: Vitamin E-supplemented diets reduce lipid peroxidation but do not alter either pituitary-adrenal, glucose, and lactate responses to immobilization stress or gastric ulceration.
abstract: It has been suggested that antioxidant administration to rats would reduce the physiological response to stress. In the present experiment adult male rats were given diets supplemented with vitamin E for one or seven days before they were subjected to immobilization stress. Vitamin E administration reduced hepatic and gastric lipid peroxidation in unstressed rats but did not modify the pituitary-adrenal, glucose and lactose responses to 1 or 18 h immobilization. Similarly, gastric ulceration caused by 18 h immobilization was unaffected by the diets. These results indicate that the inhibition of lipid peroxidation does not modify the response of several, well-known, stress-markers in the rat.
authors.affiliation: Departmento de Biología Celular y Fisiología, Facultad de Ciencias, Universidad Autónoma de Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Armario
authors.forename: L
authors.initials: L
authors.lastname: Campmany
authors.forename: M
authors.initials: M
authors.lastname: Borras
authors.forename: J
authors.initials: J
authors.lastname: Hidalgo
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004032:Diet; D005753:Gastric Mucosa / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007773:Lactates; D014810:Vitamin E; D019344:Lactic Acid; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone