[Proof of stimulating effect of dalargin of the process of cell division through opiate receptors].
The role of opiate receptors on cell division in corneal epithelium during administration of dalargin was analysed. Naloxone injection/200 micrograms/kg/decreased MI two times, DNA-synthesis 1.4 times over 24 hours. Naloxone prevented dalargin effect on cell proliferation. Another testimonies of dalargin opiate-binding mitogenic effect were the results of the study with dalargin analogues. They are agonists of opiate receptors too. These drugs, as well as dalargin, in a dose 10 micrograms/kg increased DNA-synthesis 1.5 times, MI and MIK 2.2 times. It turned out, that the administration of another two analogues of dalargin, which are not ligands of opiate receptors, probably do not cause an adequate increase of DNA-synthesis and mitotic index.
Pan'kova
T D
TD
Timoshin
S S
SS
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000166:cytology / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008024:Ligands; D008297:Male; D008940:Mitotic Index; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology*
D008024:Ligands; D011957:Receptors, Opioid; D013565:Sympatholytics; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Dokazatel'stva realizatsii stimuliruiushchego éffekta dalargina na protsess kletochnogo deleniia cherez opiatnye retseptory.