title: [Acyclovir and specific anti-varicella-herpes zoster immunoglobulins in the treatment of varicella-zoster virus infection in 113 adults].
abstract: From January 1978 to December 1988, 54 males and 59 females were treated for varicella, zoster and disseminated zoster by varicella-zoster immunoglobulin (group I) or acyclovir (group II). 67 patients had immune deficiency disease. Treatment was successful for 92/100 patients in group I and for 100/100 patients in group II. Thrombophlebitis and renal failure were observed in group II and regressed when acyclovir was stopped. Varicella-zoster immunoglobulin and acyclovir are two effective therapeutics in the treatment of varicella and zoster in adults including immunocompromised patients. The use of acyclovir could not reduce the duration of hospitalization.
authors.affiliation: Service Régional des Maladies Infectieuses, Centre Hospitalier, Tourcoing.
authors.forename: E
authors.initials: E
authors.lastname: Senneville
authors.forename: C
authors.initials: C
authors.lastname: Chidiac
authors.forename: M
authors.initials: M
authors.lastname: Brouillard
authors.forename: C
authors.initials: C
authors.lastname: Beuscart
authors.forename: O
authors.initials: O
authors.lastname: Leroy
authors.forename: B
authors.initials: B
authors.lastname: Sivery
authors.forename: G
authors.initials: G
authors.lastname: Beaucaire
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D002644:Chickenpox / Q000188:drug therapy* / Q000628:therapy; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy* / Q000628:therapy; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D008297:Male
chemical_list: D007136:Immunoglobulins; D000212:Acyclovir
vernacular_title: Aciclovir et immunoglobulines spécifiques anti-varicelle-zona dans le traitement des infections par le virus de la varicelle et du zona chez 113 adultes.