Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus.
The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
Tancredi
V
V
Dipartimento Medicina Sperimentale e Scienze Biochimiche, Università di Roma Tor Vergata, Italy.
Zona
C
C
Velotti
F
F
Eusebi
F
F
Santoni
A
A
D000818:Animals; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D007376:Interleukin-2; D011994:Recombinant Proteins