title: Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension.
abstract: The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg aspartate (20 mmol elemental Mg twice daily) and six received placebo for 3 mo. In comparison with placebo treatment, magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism. These results demonstrate that in magnesium-repleted hypertensive subjects, magnesium supplementation does not affect blood pressure or lipids probably because magnesium has no effect on cellular cation metabolism in magnesium-replete individuals.
authors.affiliation: Division of Endocrinology, Nutrition and Hypertension, Wayne State University, School of Medicine, Detroit, MI.
authors.forename: P C
authors.initials: PC
authors.lastname: Zemel
authors.forename: M B
authors.initials: MB
authors.lastname: Zemel
authors.forename: M
authors.initials: M
authors.lastname: Urberg
authors.forename: F L
authors.initials: FL
authors.lastname: Douglas
authors.forename: R
authors.initials: R
authors.lastname: Geiser
authors.forename: J R
authors.initials: JR
authors.lastname: Sowers
mesh_terms: D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004311:Double-Blind Method; D004573:Electrolytes / Q000097:blood / Q000652:urine; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012083:Renin / Q000097:blood
chemical_list: D004573:Electrolytes; D008055:Lipids; D001224:Aspartic Acid; D012083:Renin