title: Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.
abstract: Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.
authors.affiliation: Department of Medical Biochemistry, University of Calgary Medical Sciences Centre, Alberta, Canada.
authors.forename: T O
authors.initials: TO
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: J D
authors.initials: JD
authors.lastname: Bjorge
authors.forename: D J
authors.initials: DJ
authors.lastname: Fujita
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000201:enzymology / Q000235:genetics; D002642:Chick Embryo; D005347:Fibroblasts / Q000201:enzymology; D005822:Genetic Vectors; D006801:Humans; D009154:Mutation; D015688:Oncogene Protein pp60(v-src) / Q000235:genetics* / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics* / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection
chemical_list: D010770:Phosphotransferases; D019870:1-Phosphatidylinositol 4-Kinase; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src)