[Study of the protective action of nedocromil sodium with bronchial cold-air provocation in children with bronchial asthma].
12 children with known bronchial hyperreactivity and asthma had isocapnic cold air hyperventilation challenges of their bronchial airways. In a double-blind cross-over study they inhaled either placebo or nedocromil sodium (2 puffs à 2 mg) from a MDI before challenge. 2 subjects were found to be non-responders during the two days of the study. The remainder all reacted on the placebo days, while 5 subjects were completely protected on the nedocromil-days and 5 subjects were partially protected. Nedocromil is a potent agent for the suppression of bronchial hyperresponsiveness.
Wönne
R
R
Zentrum der Kinderheilkunde der Johann Wolfgang Goethe-Universität Frankfurt am Main.
Mönkhoff
M
M
Ahrens
P
P
Hofmann
D
D
D000388:Air; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control*; D001985:Bronchial Provocation Tests; D002648:Child; D003080:Cold Temperature; D004311:Double-Blind Method; D006801:Humans; D017835:Nedocromil; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D012129:Respiratory Function Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015363:Quinolones; D017835:Nedocromil
Untersuchung der protektiven Wirkung von Nedocromil-Natrium mit bronchialen Kaltluftprovokationen bei Kindern mit Asthma bronchiale.