title: Submandibular gland tumors. Adverse histologic factors and therapeutic implications.
abstract: We reviewed our 41-year experience with tumors of the submandibular gland to determine what factors influence outcome and their implications for treatment. The most common benign neoplasm was pleomorphic adenoma (21), while among malignant tumors the adenoid cystic variety (37) predominated. For the 86 patients who had malignant tumors, the 2- and 5-year survivals by the life table method were 82% and 69%, respectively. For patients with malignant tumors, histology, size, perineural invasion, and prior treatment did not affect overall survival. Factors adversely affecting outcome were extraglandular soft-tissue extension and lymph node metastasis. Local-regional control was enhanced in patients with soft-tissue extension if they were treated by surgery followed by radiotherapy rather than by surgery alone.
authors.affiliation: Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: R S
authors.initials: RS
authors.lastname: Weber
authors.forename: R M
authors.initials: RM
authors.lastname: Byers
authors.forename: B
authors.initials: B
authors.lastname: Petit
authors.forename: P
authors.initials: P
authors.lastname: Wolf
authors.forename: K
authors.initials: K
authors.lastname: Ang
authors.forename: M
authors.initials: M
authors.lastname: Luna
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008949:Adenoma, Pleomorphic / Q000401:mortality / Q000556:secondary / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002648:Child; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000628:therapy; D013365:Submandibular Gland Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate