title: Third interim report of the nationwide collaborative study on the long-term effects of bromocriptine in the treatment of parkinsonian patients.
abstract: The interim results obtained up to the end of the 3rd year of the multicenter nationwide cooperative study on the long-term effects of bromocriptine in parkinsonian patients are reported. Bromocriptine monotherapy could be continued in approximately 33% of the patients at the mean maintenance dose of 11.4 mg/day. The combined use of bromocriptine (11.1 mg/day) in parkinsonian patients already treated with levodopa had a favorable influence on the long-term side effects of levodopa such as the on-off phenomenon and dyskinesia. The beneficial effects of bromocriptine, levodopa and an early combination on parkinsonian symptoms such as rigidity and tremor remained at the end of the 3rd year. However, the effects of each mode of therapy on another parkinsonian symptom, akinesia, ceased by the end of the 3rd year.
authors.affiliation: Institute of Clinical Medicine, University of Tsukuba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: I
authors.initials: I
authors.lastname: Kanazawa
authors.forename: I
authors.initials: I
authors.lastname: Goto
authors.forename: M
authors.initials: M
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Kowa
authors.forename: T
authors.initials: T
authors.lastname: Mannen
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: H
authors.initials: H
authors.lastname: Nishitani
authors.forename: N
authors.initials: N
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001971:Bromocriptine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006801:Humans; D007564:Japan; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D001971:Bromocriptine; D007980:Levodopa