title: Ganciclovir and standard high-dose immunoglobulins for the treatment of cytomegalovirus interstitial pneumonia in a bone marrow recipient.
abstract: A 47-year-old woman received an allogeneic bone marrow infusion because of chronic myeloid leukemia. Two months after the transplant she developed an interstitial pneumonia: bronchoalveolar lavage yielded cytomegalic cells with intranuclear bodies, and cytomegalovirus DNA was detected by in situ hybridization techniques. Ganciclovir and standard high-dose immunoglobulins were administered to the patient with resolution of the pneumonia. No relapse of pneumonia was observed after a 4-month follow-up. It seems that the favorable outcome of the potentially fatal pneumonia observed in this patient might be related to early diagnosis, and prompt administration of ganciclovir and standard high-dose immunoglobulins.
authors.affiliation: Dipartimento di Biopatologia Umana, Università La Sapienza, Roma, Italy.
authors.forename: A P
authors.initials: AP
authors.lastname: Iori
authors.forename: G
authors.initials: G
authors.lastname: Gentile
authors.forename: P
authors.initials: P
authors.lastname: Petasecca Donati
authors.forename: W
authors.initials: W
authors.lastname: Arcese
authors.forename: P
authors.initials: P
authors.lastname: Martino
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007116:Immunization, Passive; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*
chemical_list: D015774:Ganciclovir