Effects of N-methyl-D-aspartate (NMDA) antagonist MK-801 on breathing pattern in rats.
In anaesthetized, bivagotomized and artificially ventilated rats, the respiratory effects of systemic injection of MK-801, a non-competitive N-methyl-D-aspartate antagonist, were studied. In all the experiments (n = 11), the injection increased the inspiratory duration and decreased the expiratory duration. In 4 experiments, the inspiratory duration was drastically lengthened, resulting in an apneustic-like breathing pattern. These results demonstrate that apneusis is difficult but possible to induce in rats and suggest that termination of inspiration is controlled via central mechanisms in which NMDA-like receptors are involved.
Monteau
R
R
Département de Physiologie et Neurophysiologie, Equipe Biologie des Rythmes et du Développement, Faculté des Sciences et Techniques, St. Jérôme, Marseilles, France.
Gauthier
P
P
Rega
P
P
Hilaire
G
G
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000187:drug effects* / Q000502:physiology
D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate