Chronic stress-induced changes in locus coeruleus neuronal activity.
Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.
Pavcovich
L A
LA
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Cancela
L M
LM
Volosin
M
M
Molina
V A
VA
Ramirez
O A
OA
D000200:Action Potentials; D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008125:Locus Coeruleus / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha; D003000:Clonidine; D009638:Norepinephrine