Failure of (+)-naloxone to accelerate feline colonic transit.
To determine whether the colonic transit accelerating effect of (-)-naloxone (0.3 mg/kg, i.m.) is due to an action at opioid receptors or a direct pharmacologic effect, its enantiomer, (+)-naloxone (0.3 mg/kg, i.m.), was administered to cats and compared to saline control using colonic transit scintigraphy. Transit was not accelerated by (+)-naloxone. The effects of naloxone on colonic transit are thus stereospecific, and are probably mediated by opioid receptors.
Krevsky
B
B
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Fisher
R S
RS
Cowan
A
A
D000818:Animals; D002415:Cats; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D009270:Naloxone / Q000493:pharmacokinetics / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D009270:Naloxone