title: Comparative biology of natural and experimental SIVmac infection in macaque monkeys: a review.
abstract: Epidemiologic and clinicopathologic data from 11 macaques with naturally acquired SIV infection--10 of which have died--were compared with those from 34 rhesus monkeys that have died of experimental SIVmac infection. Several differences, including gender affected, age at time of death, and the occurrence of certain opportunistic infections, could be explained by the experimental design; others remained unexplained. The most striking difference was the 41% incidence of meningoencephalomyelitis in the experimental group and its absence in naturally SIV-infected animals.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, MA.
authors.forename: N W
authors.initials: NW
authors.lastname: King
authors.forename: L V
authors.initials: LV
authors.lastname: Chalifoux
authors.forename: D J
authors.initials: DJ
authors.lastname: Ringler
authors.forename: M S
authors.initials: MS
authors.lastname: Wyand
authors.forename: P K
authors.initials: PK
authors.lastname: Sehgal
authors.forename: M D
authors.initials: MD
authors.lastname: Daniel
authors.forename: N L
authors.initials: NL
authors.lastname: Letvin
authors.forename: R C
authors.initials: RC
authors.lastname: Desrosiers
authors.forename: B J
authors.initials: BJ
authors.lastname: Blake
authors.forename: R D
authors.initials: RD
authors.lastname: Hunt
mesh_terms: D000367:Age Factors; D000818:Animals; D004679:Encephalomyelitis / Q000150:complications / Q000662:veterinary; D005260:Female; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology*; D009894:Opportunistic Infections / Q000150:complications*; D012192:Retroviridae Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D012737:Sex Factors; D015302:Simian Immunodeficiency Virus