title: [Endogenous factors of neurodestruction (the pharmacologic aspects)].
abstract: The data on the biochemical mechanisms of the development of neurodestruction are presented. The emphasis is given to glutamate- and aspartate-induced lesions of the brain in hypoxia, hypoglycemia, trauma. The common mechanisms related to secondary hyperfunction of glutamate- and aspartatergic systems underlie the development of chronic neurodegenerative processes in Alzheimer's disease, Huntington's disease, senile dementia, alcoholism, schizophrenia, etc. The basic pharmacological approaches to prevention of destructive processes in the central nervous system are considered.
authors.forename: V L
authors.initials: VL
authors.lastname: Kozlovskiĭ
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D009410:Nerve Degeneration / Q000187:drug effects* / Q000502:physiology*; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism
chemical_list: D005971:Glutamates; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; C031959:aspartic acid receptor; D001224:Aspartic Acid
vernacular_title: Endogennye faktory neĭrodestruktsii (farmakologicheskie aspekty).