Importance of compression onset rate for the degree of impairment of impulse propagation in experimental compression injury of the porcine cauda equina.
The effects of a rapid (0.05-0.1 seconds) and a slow (20 seconds) onset rate of cauda equina compression on impulse propagation, in terms of tail muscle electromyogram (EMG) amplitude, were analyzed in an experimental model of the pig cauda equina. Sham compression and compression at 50 mm Hg at either rapid or slow onset induced no or only minor functional impairment. Compression at 100 or 200 mm Hg induced impairment of the impulse propagation that was proportional to the applied pressure. The effects were more pronounced (P less than 0.01) for the rapid than for the slow onset of compression at both these pressure levels. An important factor for this observed difference in effects between the two employed onset rates seems to be the magnitude of intraneural edema formed outside the compression zone.
Olmarker
K
K
Department of Anatomy, Sahlgren Hospital, Gothenburg University, Sweden.
Holm
S
S
Rydevik
B
B
D000818:Animals; D002420:Cauda Equina / Q000293:injuries* / Q000503:physiopathology; D004576:Electromyography; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D013552:Swine; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors