[Selection of a herpes simplex mutant virus of weak pathogenicity, sensitive to acyclovir and not susceptible to reactivation in vivo].
From a KOS herpes simplex virus strain prepared in VERO cells we have been able to obtain after several exposures to increasing concentrations of trifluorothymidine, four resistant mutants. Among these strains, 31 T mutant was a TK-altered strain of low pathogenicity, sensible to acyclovir and did not induce recurrences. These properties might allow the use of such a strain as a living attenuated antiherpetic vaccine.
Colin
J
J
Laboratoires d'Ophtalmologie et de Virologie, Centre Hospitalier Universitaire de Brest.
Jouppe
B
B
Robinet
A
A
Huraux
J M
JM
Chastel
C
C
D000212:Acyclovir / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*
D000212:Acyclovir
Sélection d'un mutant d'herpès simplex virus de faible pathogénicité, sensible à l'acyclovir et non réactivable in vivo.