Oxygen radical scavenging activity of phenylbutenones and their correlation with antiinflammatory activity.
A number of ring substituted(E)-4-phenyl-3-buten-2-ones including dehydrozingerone were studied for their oxygen radical scavenging properties. They scavenged superoxide and hydroxyl radicals to an appreciable extent. Good correlation (r = 0.87) was obtained between superoxide scavenging and antiinflammatory activity. The correlation was not significant with the hydroxyl scavenging activity.
Saldanha
L A
LA
College of Pharmaceutical Sciences, Manipal, India.
Elias
G
G
Rao
M N
MN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002074:Butanones / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012044:Regression Analysis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides