title: The microbiology of periapical granulomas.
abstract: Of the 16 periapical granulomas studied, 14 (88%) yielded a positive growth when homogenized and cultured. The concentration of colony-forming units per milliliter of the suspension ranged from 10(1.3) to 10(4.0) (mean 10(2.2)). A total of 47 isolates comprising 26 (55%) facultative anaerobes and 21 (45%) strict anaerobes were obtained. The organisms most commonly cultured were Veillonella species (15%), Streptococcus milleri (11%), Streptococcus sanguis (11%), Actinomyces naeslundii (11%), Propionibacterium acnes (11%), and Bacteroides species (10%). Most of the organisms (96%) were sensitive to either amoxicillin, clindamycin, or tetracycline, whereas only 45% were sensitive to metronidazole.
authors.affiliation: Oral Microbiology Unit, Dental Hospital and School, Glasgow.
authors.forename: C
authors.initials: C
authors.lastname: Iwu
authors.forename: T W
authors.initials: TW
authors.lastname: MacFarlane
authors.forename: D
authors.initials: D
authors.lastname: MacKenzie
authors.forename: D
authors.initials: D
authors.lastname: Stenhouse
mesh_terms: D000293:Adolescent; D000328:Adult; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000302:isolation & purification*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D008875:Middle Aged; D010484:Periapical Granuloma / Q000382:microbiology*