[Antibodies against D-penicillamine in primary biliary cirrhosis].
25 serum samples of 22 patients with primary biliary cirrhosis (15 under or after treatment with D-penicillamine) were tested for antibodies against D-penicillamine. Complement-binding IgG-antibodies demonstrated by a 4 layer immunofluorescence test were found only in 3 patients with suggested D-penicillamine allergy. These findings suggest a causal relation between penicillamine antibodies and penicillamine-induced side effects.
Storch
W
W
Rheumaklinik Bad Driburg.
D004342:Drug Hypersensitivity / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy*; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D007074:Immunoglobulin G; D010396:Penicillamine
Antikörper gegen D-Penicillamin bei primär biliärer.