[The oxidative burst in the determination of immune response to synthetic materials].
Macrophages play an important role at the implant-tissue interface. Their activity is extremely complex but above all they are phagocytic cells. Phagocytosis is accompanied by a sequence of biochemical reactions known as "the oxidative burst" (BO). The fundamental physiological significance of this phenomenon is to provide the phagocytes with an efficient microbicidal mechanism. Our aim was to prepare an objective method for screening biomaterials that could influence macrophagic defence mechanisms against a possible implant contamination.
Buscaroli
S
S
Laboratorio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla-Putti, Bologna.
Stea
S
S
Arciola
C R
CR
Rocca
M
M
Nicoli Aldini
N
N
Fini
M
M
Mancini
I
I
Giardino
R
R
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010587:Phagocytosis; D013053:Spectrophotometry; D013481:Superoxides / Q000032:analysis
D001672:Biocompatible Materials; D013481:Superoxides
II burst ossidativo per la determinazione della risposta immunitaria ai materiali di sintesi.