Mediation of nitrous oxide analgesia in mice by spinal and supraspinal kappa-opioid receptors.
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal constriction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with beta-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal kappa-opioid receptors.
Quock
R M
RM
Department of Basic Sciences, Marquette University School of Dentistry, Milwaukee, WI 53233.
Best
J A
JA
Chen
D C
DC
Vaughn
L K
LK
Portoghese
P S
PS
Takemori
A E
AE
D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009609:Nitrous Oxide / Q000494:pharmacology*; D010147:Pain Measurement; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*
D000700:Analgesics; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; C024524:beta-funaltrexamine; D009609:Nitrous Oxide