[The possible participation of N-methyl-D-aspartate receptors in the stimulating action on respiration of thyroliberin and its analog RGH 2202].
The effects of ketamine and an antagonist of N-methyl-D-aspartate receptors dibenzocyclohepteniline maleate (MK-801) on the changes in the bioelectrical activity of the diaphragm induced by thyroliberine and its analogue L-pyro-2-aminoadipil-L-leucyl-proline amide (RGH 2202) were studied in experiments on vagotomized urethane-anesthetized rats. It was shown that ketamine (5 mg/kg, intravenously) and MK-801 (1 mg/kg, intravenously) eliminate and prevent an increase of the index of pulmonary ventilation caused by thyroliberine (5 mg/kg, intravenously) and RGH 2202 (5 mg/kg, intravenously). The data obtained suggest the involvement of N-methyl-D-aspartate receptors in the mechanism of the stimulating effects of thyroliberine and its analogue on respiration.
Chizh
B A
BA
Kasparov
S A
SA
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000502:physiology; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D016291:Dizocilpine Maleate; D004347:Drug Interactions; D007649:Ketamine / Q000494:pharmacology; D016202:N-Methylaspartate; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014628:Vagotomy
D003986:Dibenzocycloheptenes; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D001224:Aspartic Acid; D013973:Thyrotropin-Releasing Hormone; D016202:N-Methylaspartate; D007649:Ketamine; D016291:Dizocilpine Maleate; C055448:posatirelin
Vozmozhnoe uchastie retseptorov N-metil-D-aspartata v stimuliruiushchem deĭstvii na dykhanie tiroliberina i ego analoga RGH 2202.