title: Effects of hypertonic peritoneal dialysis solutions on neutrophil superoxide production.
abstract: Superoxide produced by neutrophils plays an important role in the killing of bacterial pathogens. The effects of glucose-containing peritoneal dialysis solutions on superoxide production by canine and human neutrophils were studied. A significant decrement in superoxide generation was noted with the 2.27% and 3.86% glucose solutions. The results suggest that hypertonic peritoneal dialysis solutions curtail neutrophil superoxide generation.
authors.affiliation: Department of Medicine, Veterans Administration Hospital, Hines, IL 60141.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Zhou
authors.forename: F J
authors.initials: FJ
authors.lastname: Manahan
authors.forename: A W
authors.initials: AW
authors.lastname: Yu
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
authors.forename: Z M
authors.initials: ZM
authors.lastname: Nawab
authors.forename: K A
authors.initials: KA
authors.lastname: Fisher
authors.forename: T S
authors.initials: TS
authors.lastname: Ing
mesh_terms: D000818:Animals; D015314:Dialysis Solutions / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
chemical_list: D015314:Dialysis Solutions; D005950:Glucose Solution, Hypertonic; D013481:Superoxides