title: [Blood platelet alpha adrenergic receptors in congestive heart failure. Effects of ACE inhibition].
abstract: Platelet alpha-2-adrenergic receptor number and affinity were examined in 12 patients with class IV NYHA congestive heart failure (CHF) and 10 normal volunteers paired for age and sex. Platelet alpha-2-adrenergic receptor number is significantly decreased in CHF patients (178 +/- 18 fmol/mg prot. vs 282 +/- 21 fmol/mg prot. p less than 0.05). After Captopril treatment (6 weeks) alpha-2-receptor number increased but this increase was not statistically significant (236 +/- 28 fmol/mg prot.). This study supports the hypothesis that increased levels of circulating catecholamines in CHF lead to a decrease in platelet alpha-2-adrenoreceptors. Improved cardiac function following administration of Captopril could lead to a withdrawal of sympathetic tone. Captopril may also interact with sympathetic nervous function.
authors.affiliation: Istituto di Clinica medica I, Università, I.R.C.C.S., Policlinico S. Matteo, Pavia.
authors.forename: A
authors.initials: A
authors.lastname: Radaelli
authors.forename: A
authors.initials: A
authors.lastname: Caporotondi
authors.forename: A
authors.initials: A
authors.lastname: Bongarzoni
authors.forename: C
authors.initials: C
authors.lastname: Muggia
authors.forename: C
authors.initials: C
authors.lastname: Manzinali
authors.forename: E
authors.initials: E
authors.lastname: Marchesi
mesh_terms: D000368:Aged; D001792:Blood Platelets; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D011942:Receptors, Adrenergic, alpha; D002216:Captopril
vernacular_title: I recettori alfa adrenergici piastrinici nello scompenso cardiaco congestizio. Effetti dell'ACE-inibizione.