title: [Clinico-immunologic correlations and various characteristics of the lymphocyte receptors in hepatocerebral dystrophy].
abstract: Clinical and immunological studies were performed in 45 patients with HCD. A group of patients was investigated by conventional immunology tests. spontaneous and active rosette formation, theophylline test, immunofluorescent B-lymphocyte investigation, IgA, IgM, IgG and circulating immune complexes (IC) levels measurement. Monoclonal antibodies were used to count T- and B-lymphocytes, T-helpers and T-suppressors in another group. [3H]-spiroperidol binding to blood lymphocytes was studied in 28 patients. Immune indices were found to be related to the disease duration, degree of visceral deterioration and the duration of Cu-depleting drugs administration. After a prolonged treatment with D-Penicillamin or Cuprenil immune indices returned to normal levels while the count of theophylline-sensitive lymphocytes remained unchanged. The mechanisms of metabolic and immune interrelations in HCD are discussed.
authors.forename: I V
authors.initials: IV
authors.lastname: Gannushkina
authors.forename: I G
authors.initials: IG
authors.lastname: Zhirnova
authors.forename: A
authors.initials: A
authors.lastname: Chlonkovska
authors.forename: E D
authors.initials: ED
authors.lastname: Markova
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova-Smolenskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Poleshchuk
authors.forename: L V
authors.initials: LV
authors.lastname: Komel'kova
authors.forename: R K
authors.initials: RK
authors.lastname: Katosova
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006527:Hepatolenticular Degeneration / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008231:Lymphopenia / Q000209:etiology; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011971:Receptors, Immunologic
vernacular_title: Kliniko-immunologicheskie sopostavleniia i nekotorye osobennosti retseptorov limfotsitov pri gepatotserebral'noĭ distrofii.