[Detection of Epstein-Barr virus in the tonsils in infectious mononucleosis].
Tonsils of 50 patients with infectious mononucleosis were examined for the presence of Epstein-Barr virus nuclear antigens (EBNA) and in 11 cases for the presence of Epstein-Barr virus (EBV) nucleic acid sequences. In tonsillar tissue of 42 patients less than 1 to 40 per cent EBNA-positive cells could be demonstrated by anticomplement immunofluorescence. 10 out of 11 tonsils examined by in situ hybridization contained less than 1 to 50 per cent cells with EBV nucleic acid sequences. The histological examination indicated that cells labelled by in situ hybridisation are in the majority proliferating B-lymphocytes and to a small extent cells of tonsillar epithelium.
Sauerbrei
A
A
Institut für Medizinische Mikrobiologie, Medizinische Akademie Erfurt.
Färber
I
I
Wutzler
P
P
Swoboda
R
R
Schneider
J
J
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D014066:Palatine Tonsil / Q000382:microbiology* / Q000473:pathology
D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens
Nachweis des Epstein-Barr-Virus in Tonsillen bei infektiöser Mononukleose.