Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial.
A double-blind study was performed comparing 5 mg delta-9-tetrahydrocannabinol (THC) p.o., 50 mg codeine p.o., and placebo in a patient with spasticity and pain due to spinal cord injury. The three conditions were applied 18 times each in a randomized and balanced order. Delta-9-THC and codeine both had an analgesic effect in comparison with placebo. Only delta-9-THC showed a significant beneficial effect on spasticity. In the dosage of THC used no altered consciousness occurred.
Maurer
M
M
PSIN - Psychologisches Institut für Beratung und Forschung, Zürich, Switzerland.
Henn
V
V
Dittrich
A
A
Hofmann
A
A
D000328:Adult; D004311:Double-Blind Method; D013759:Dronabinol / Q000008:administration & dosage*; D004806:Ependymoma / Q000601:surgery*; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D010147:Pain Measurement; D015493:Paraparesis, Tropical Spastic / Q000188:drug therapy*; D010292:Paresthesia / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy*; D013120:Spinal Cord Neoplasms / Q000601:surgery*
D013759:Dronabinol