Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and HIV.
We determined IgG antibodies against Human Herpesvirus-6 (strain Uganda 1102, M. D. Griffin, London) in the indirect immunofluorescence test in sera from 1105 persons of various age groups. Of these sera 570 were retested using HHV-6 strain St. W. (Prof. Schneweis, Bonn). We could confirm that maternal antibodies decrease between birth and six months of age and the seropositive rate rises rapidly between seven months and five years of age up to 79.5%. Between six and ten years and up to 40 years, the antibody-positive rate lies around 81.3% and 66%, respectively. To confirm the causal nature of human herpes virus type 6 (HHV-6) for exanthema subitum we could demonstrate eight seroconversions testing sera from 14 patients with roseola infantum. In addition, the virus was isolated from peripheral blood lymphocytes of children during the acute fever phase in four cases in tissue culture and in six cases the virus was detected by positive hybridization. In single and some paired sera from patients with acute exanthematous diseases, rubella (n = 28), parvovirus B 19 (n = 24), measles (n = 17), mumps (n = 27), adenovirus (n = 27) and parinfluenza virus type 3 (n = 28) and in sera from patients with Kawasaki syndrome (n = 20), acute varicella-zoster- (n = 27), acute herpes simplex- (n = 18) and HIV-1 infection (n = 50), we found no HHV-6 IgM antibodies and no HHV-6 IgG antibody rises. We could only demonstrate an HHV-6 seropositive rate according to our age-prevalence study.(ABSTRACT TRUNCATED AT 250 WORDS)
Enders
G
G
Inst. f. med. Virologie u. Infektions-epidemiologie, Stuttgart, FR Germany.
Biber
M
M
Meyer
G
G
Helftenbein
E
E
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005077:Exanthema Subitum / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000382:microbiology; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000382:microbiology*; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology / Q000382:microbiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D014777:Virus Diseases / Q000453:epidemiology / Q000382:microbiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M