[The characteristics of the action of calcium antagonists on glucose transport in the rat small intestine].
Ca antagonists reduced intestinal glucose transport in vitro and in vivo. The Ca-channel blocking agent verapamil (B) and calmodulin inhibitors chlorpromazine, triftasine (I) exerted rather unequal effects on glucose transport: B exerting a weaker effect on the transport from serosa than I. B and Ca-free medium reduced Vmax with no changes at Km as opposed to I. Under the influence of EDTA (5 mmol/l) there only is an unsaturated glucose transport. Ca- and calmodulin-affinity sites seem to play a major role in the regulation of enterocyte glucose transport system.
Gurman
E G
EG
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002746:Chlorpromazine / Q000494:pharmacology; D003864:Depression, Chemical; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D002147:Calmodulin; D014268:Trifluoperazine; D014700:Verapamil; D005947:Glucose; D002746:Chlorpromazine
Osobennosti deĭstviia antagonistov kal'tsiia na transport gliukozy v tonkoĭ kishke krys.