title: Cyclic AMP second messenger signal generation in EBV-transformed lymphoblastoid cells from schizophrenic patients.
abstract: Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age- and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects.
authors.affiliation: Department of Psychiatric Research, Ezrath Nashim Hospital, Jerusalem, Israel.
authors.forename: R P
authors.initials: RP
authors.lastname: Ebstein
authors.forename: E R
authors.initials: ER
authors.lastname: Bennett
authors.forename: J
authors.initials: J
authors.lastname: Hadjez
authors.forename: H
authors.initials: H
authors.lastname: Silver
authors.forename: S
authors.initials: S
authors.lastname: Yedgar
authors.forename: B
authors.initials: B
authors.lastname: Lerer
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics; D002461:Cell Line, Transformed; D000242:Cyclic AMP / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D000242:Cyclic AMP; D000262:Adenylyl Cyclases