title: Successful strategy for prevention of cytomegalovirus interstitial pneumonia after human leukocyte antigen-identical bone marrow transplantation.
abstract: Cytomegalovirus (CMV) interstitial pneumonia is a frequent and often fatal complication of allogeneic bone marrow transplantation. Because therapy for CMV pneumonia was, until recently, largely ineffective, prophylactic methods were explored. This study shows that the strategy of using CMV seronegative blood products for seronegative patients with seronegative donors or weekly administration of intravenous immunoglobulin for all other patients reduced the attack rate of CMV pneumonia. The results of this study are put into the perspective of previously published data.
authors.affiliation: Department of Medicine, College of Medicine, J. Hillis Miller Health Center, University of Florida, Gainesville.
authors.forename: G J
authors.initials: GJ
authors.lastname: Elfenbein
authors.forename: T
authors.initials: T
authors.lastname: Siddiqui
authors.forename: K H
authors.initials: KH
authors.lastname: Rand
authors.forename: J
authors.initials: J
authors.lastname: Graham-Pole
authors.forename: R B
authors.initials: RB
authors.lastname: Marcus
authors.forename: N P
authors.initials: NP
authors.lastname: Mendenhall
authors.forename: T M
authors.initials: TM
authors.lastname: Goedert
authors.forename: T
authors.initials: T
authors.lastname: Wikle-Fisher
authors.forename: S A
authors.initials: SA
authors.lastname: Gross
authors.forename: R S
authors.initials: RS
authors.lastname: Weiner
mesh_terms: D000293:Adolescent; D000328:Adult; D001688:Biological Products / Q000592:standards*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006680:HLA Antigens; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D011658:Pulmonary Fibrosis / Q000517:prevention & control*; D012307:Risk Factors; D014184:Transplantation, Homologous
chemical_list: D001688:Biological Products; D006680:HLA Antigens