Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.
Two unnatural L-oligodeoxyribonucleotides, namely alpha- and beta-L-dT8pO(CH2)3OH, have been synthesized. These oligomers are resistant towards nuclease degradation. They do not show any UV detectable base pairing with beta-D-dA8 and poly rA.
Morvan
F
F
Université de Montpellier II, Laboratoire de Chimie Bio-Organique, URA 488, France.
Génu
C
C
Rayner
B
B
Gosselin
G
G
Imbach
J L
JL
D000818:Animals; D001482:Base Composition; D002417:Cattle; D007202:Indicators and Reagents; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism; D013154:Spleen / Q000201:enzymology
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; C027903:oligo (dT); D015719:Single-Strand Specific DNA and RNA Endonucleases; D010727:Phosphoric Diester Hydrolases