title: Effect of food-restriction stress on immune response in mice.
abstract: Daily 23-h food deprivation for 1-5 days induced gastric ulcers and atrophic changes of the spleen and thymus, accompanied by a rise in plasma cortisol and catecholamine levels in mice. It also modulated several immune cell functions in the spleen including a drop in the B cell population but no change in the mitogen response of the B cells, an increase in T cell population but no change in the L3T4/Lyt2 ratio and an early increase in natural killer activity and O2- production by macrophages. These effects are thought to correlate to the increase in stress-associated humoral factors and this may partly result from stress induced by food restriction.
authors.affiliation: Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Aoike
authors.forename: T
authors.initials: T
authors.lastname: Hosokawa
authors.forename: K
authors.initials: K
authors.lastname: Rokutan
authors.forename: K
authors.initials: K
authors.lastname: Koyama
authors.forename: Y
authors.initials: Y
authors.lastname: Nishi
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000818:Animals; D001835:Body Weight; D002395:Catecholamines / Q000097:blood; D005434:Flow Cytometry; D005508:Food Deprivation; D006854:Hydrocortisone / Q000097:blood; D007107:Immune System / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size; D013312:Stress, Physiological / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D002395:Catecholamines; D013481:Superoxides; D006854:Hydrocortisone