Muscle biopsy findings in systemic capillary leak syndrome.
Two patients with systemic capillary leak syndrome (SCLS) were followed up clinically for 5 and 2 years, respectively. Muscle biopsy was performed 1 week after the end of an acute crisis in one patient, and after 3 years in the other. In both cases, muscle capillary basement membranes were extremely thick--more than 15 times thicker than normal. Capillary basement membrane enlargement appears to be a permanent lesion, probably limited to muscle vessels. This finding has not been previously reported in SCLS, and would appear to indicate a relationship with the pathogenesis and severity of the crisis.
Navarro
C
C
Department of Internal Medicine, University Hospital, Barcelona, Spain.
García-Bragado
F
F
Lima
J
J
Fernández
J M
JM
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D001706:Biopsy; D002196:Capillaries / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002199:Capillary Permeability; D004487:Edema / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D011506:Proteins / Q000493:pharmacokinetics; D012769:Shock / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D000936:Antigen-Antibody Complex; D011506:Proteins