title: Malignant jugulotympanic paraganglioma.
abstract: Jugulotympanic paragangliomas are neoplasms that arise in the jugular bulb (glomus jugulare tumor) or temporal bone (glomus tympanicum tumor). They are histologically similar to carotid body tumors; both are derived from extra-adrenal paraganglia. Of only 20 metastases reported, five had biopsy-proved bone involvement. We present a review of the literature of metastatic jugulotympanic paragangliomas and report a case that recurred locally with regional metastases 10 years after initial presentation and metastasized to spine 13 years later. Histologic data are reviewed, and potential treatment regimens are contrasted.
authors.affiliation: Department of Medicine, National Naval Medical Center, Bethesda, Md.
authors.forename: P A
authors.initials: PA
authors.lastname: Johnstone
authors.forename: R D
authors.initials: RD
authors.lastname: Foss
authors.forename: D J
authors.initials: DJ
authors.lastname: Desilets
mesh_terms: D000328:Adult; D005260:Female; D005925:Glomus Jugulare Tumor / Q000473:pathology*; D006801:Humans; D009362:Neoplasm Metastasis; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology*; D013125:Spinal Neoplasms / Q000556:secondary*