Naturally acquired enteric adenovirus infection in Syrian hamsters (Mesocricetus auratus).
Intranuclear inclusions indicative of adenovirus infection were detected microscopically in formalin-fixed intestinal tissues from preweanling Syrian hamsters. The amphophilic intranuclear inclusion bodies were observed in ileal enterocytes from 16-to 24-day-old hamsters. Electron microscopy revealed large numbers of 72 +/- 3-nm viral particles typical of adenoviridae in enterocytic nuclei. Serum antibodies reacted with mouse adenovirus strains K87 and, to a lesser extent, FL, by indirect fluorescent antibody testing. Clinical disease was not associated with the adenoviral infections. Hamsters from 10 production colonies, including all major commercial Syrian hamster suppliers in the United States, were surveyed and all had serologic or histopathologic evidence of adenovirus infection.
Gibson
S V
SV
Research Animal Diagnostic and Investigative Laboratory, College of Veterinary Medicine, University of Missouri, Columbia 65211.
Rottinghaus
A A
AA
Wagner
J E
JE
Srills
H F
HF
Stogsdill
P L
PL
Kinden
D A
DA
D000257:Adenoviridae Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D006224:Cricetinae; D007082:Ileum / Q000166:cytology / Q000648:ultrastructure; D002479:Inclusion Bodies / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000648:ultrastructure; D008647:Mesocricetus; D008854:Microscopy, Electron