[The fusogenic properties of the cytotoxins of cobra venom in a model membrane system].
By the methods of EPR spinal probes, energy migration of triplet excitation and NMR spectroscopy, the structural changes on hydrocarbon region of membranes, the changes in dynamic state of water of lipid hydrate jacket, the intermembrane lipid material exchange and fusion of membranes induced by cytotoxins of cobra venom have been studied. The sequence of events preceded the membrane fusion is suggested. The probability of membrane fusion has been shown not to be determined by fusogenic agent structure only, but much it depends on lipid composition of membranes.
Gasanov
S E
SE
Kamaev
F G
FG
Salakhutdinov
B A
BA
Aripov
T F
TF
D000818:Animals; D003603:Cytotoxins / Q000494:pharmacology*; D004347:Drug Interactions; D004546:Elapid Venoms / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000494:pharmacology; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008561:Membrane Fusion / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism; D008567:Membranes, Artificial
D003603:Cytotoxins; D004546:Elapid Venoms; D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids; D008567:Membranes, Artificial
Issledovanie f'iuzogennykh svoĭstv tsitotoksinov iada kobry v sisteme model'nykh membran.