[The study on Chinese herbal medicinal prescription with enzyme inhibitory activity. III. The study of mao-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase].
Mao-to, a Chinese herbal medicinal prescription was studied for the inhibitory activity of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. The inhibitory activity for this enzyme depended mainly on Ephedra herb and Glycyrrhiza in this prescription. Apricot kennel acted as a mitigatory component for Ephedra herb in cAMP phosphodiesterase inhibitory test. In ephedrine and the related compounds the inhibitory activity of cAMP phosphodiesterase was not shown.
Nikaido
T
T
Toho University, School of Pharmaceutical Sciences, Chiba, Japan.
Ohmoto
T
T
Kuge
T
T
Yanagisawa
A
A
Teinozawa
K
K
Takeda
H
H
Tsukamoto
H
H
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D015105:3',5'-Cyclic-AMP Phosphodiesterases