[Transient complete somatotropin insufficiency. A retrospective study].
Two groups of patients with short stature and a limitation in the growth hormone (GH) response (peaks of 10 mU/l or below in response to 2 stimuli) differed by their GH responses at puberty: normalisation in group 1 (12 patients) and lack of normalisation in group 2 (13 patients). The condition of the patients of group 1 appeared to be less severe as judged by their initial height deficiency, their growth velocity and their GH peaks. Sex steroid hormone priming tests were highly discriminative, especially for the GH response to insulin stimulation. Other pituirary hormone deficiencies were never found in group 1, but did occur in group 2. Finally the beneficial long term effect of hGH therapy was questionable in group 1 in that there was no difference between the final heights of the treated (n = 7) and the untreated (n = 5) patients.
Weill
J
J
Endocrinologie pédiatrique, hôpital Calmette, Lille, France.
Stuckens
C
C
Ponte
C
C
D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000188:drug therapy / Q000503:physiopathology; D013006:Growth Hormone / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010290:Parents; D011628:Puberty, Delayed / Q000188:drug therapy / Q000503:physiopathology; D012189:Retrospective Studies; D013997:Time Factors
D013006:Growth Hormone
L'insuffisance somatotrope complète transitoire. Etude rétrospective.