Influence of diazepam on regenerating adrenal cortex in Wistar rats.
The influence of diazepam on the mitotic activity of regenerating adrenal cortex in male Wistar rats was investigated. Diazepam administration (5 mg/kg/day) was shown to inhibit the mitotic index of adrenocortical cells on the 4th and 8th day after adrenal enucleation combined with contralateral adrenalectomy. The possible mechanism of diazepam action is discussed.
Zieleniewski
J
J
Department of Experimental Endocrinology, Institute of Endocrinology, Medical Academy, Lódź, Poland.
Nowakowska-Jankiewicz
B
B
Stepień
H
H
D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology; D012038:Regeneration / Q000187:drug effects*
D011963:Receptors, GABA-A; D003975:Diazepam