title: Persistent rectal ulcer associated with human papillomavirus type 33 in a patient with AIDS: successful treatment with isotretinoin.
abstract: Rectal dysplasia and carcinoma associated with human papillomavirus infection are increasing in prevalence among homosexual men, particularly those infected with the human immunodeficiency virus. We report a case involving a 39-year-old homosexual man with AIDS who developed a persistent rectal ulcer. A biopsy of the ulcer revealed severe squamous dysplasia, and human papillomavirus type 33 was detected in rectal tissue with use of in situ DNA hybridization. This genotype of virus has not been previously associated with anal or rectal dysplasia in homosexual men, including those infected with the human immunodeficiency virus. The rectal ulcer resolved after 2 months of oral therapy with 60 mg/d of isotretinoin, a retinoid.
authors.affiliation: Medical Service (111), Veterans Affairs Medical Center, Tucson, Arizona 85723.
authors.forename: N M
authors.initials: NM
authors.lastname: Ampel
authors.forename: M L
authors.initials: ML
authors.lastname: Stout
authors.forename: H S
authors.initials: HS
authors.lastname: Garewal
authors.forename: J R
authors.initials: JR
authors.lastname: Davis
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001706:Biopsy; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D012002:Rectal Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D014456:Ulcer / Q000150:complications / Q000473:pathology
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral; D015474:Isotretinoin