[New molecular criteria for assessing the toxic action of hydrazine derivatives. Active forms of oxygen as the key agents in the mechanism of toxicity].
The data on metabolism of different derivatives of hydrazine are considered. The generalized conception of the toxic effect of the derivatives is suggested. It is accepted that the toxic effect is connected with an elevation of the level of superoxide radicals occurring during oxidative metabolism of hydrazines.
Avakian
A Kh
AKh
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006834:Hydrazines / Q000493:pharmacokinetics / Q000633:toxicity*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D006834:Hydrazines; D013481:Superoxides; D003577:Cytochrome P-450 Enzyme System; D013482:Superoxide Dismutase
Novye molekuliarnye kriterii otsenki toksicheskogo deĭstviia proizvodnykh gidrazina. Aktivnye formy kisloroda kak kliuchevye agenty v mekhanizme toksichnosti.