[Susceptibility of immunocompetent cells to animal viruses].
The infection of several cell lines of the immune system by animal viruses has been studied. In general, those cell lines derived either from the myeloid or from the lymphoid differentiation pathways were poorly affected by these viruses. Only Semliki Forest Virus (SFV) and poliovirus were able to replicate in most of the cell lines assayed, inhibiting the cellular protein synthesis. However, this inhibition was not accompanied by a significant expression of viral proteins. These effects were not observed with UV irradiated virus suggesting that intact viral particles were required to interfere with the host macromolecular synthesis.
López-Guerrero
J A
JA
Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, Madrid.
D002460:Cell Line; D004279:DNA, Viral / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D007121:Immunocompetence; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D008214:Lymphocytes; D009000:Monocytes; D014411:Neoplastic Stem Cells; D017955:Poliovirus / Q000502:physiology; D012672:Semliki forest virus / Q000502:physiology; D014407:Tumor Cells, Cultured; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000096:biosynthesis; D018406:Virus Physiological Phenomena; D014779:Virus Replication
D004279:DNA, Viral; D014764:Viral Proteins
Susceptibilidad de células inmunocompetentes a virus animales.