MRI quantitation of edema in focal cerebral ischemia in cats: correlation with cytochrome aa3 oxidation state.
1H MRI permits detection of edema in the brain. In a middle cerebral artery stroke model in the cat, we found a significant correlation between an edema index based on MRI and a sensitive metabolic index of ischemia, the in vivo oxidation status of mitochondrial cytochrome aa3 determined by near-infrared reflectance spectrophotometry (r = -0.70, alpha = 0.001). This result suggests that a simple, noninvasive study using MRI can provide an index of the extent of ischemic damage in an experimental acute stroke model.
Kline
R A
RA
Department of Surgery, Wayne State University, Detroit, Michigan 48201.
Negendank
W G
WG
McCoy
L E
LE
Lester
M
M
Berguer
R
R
D000818:Animals; D001929:Brain Edema / Q000175:diagnosis / Q000201:enzymology* / Q000209:etiology; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D002415:Cats; D003576:Electron Transport Complex IV / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D010084:Oxidation-Reduction
D003576:Electron Transport Complex IV