The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults.
In this analysis, the authors review studies over the last 50 years addressing the association between long-term survival and type of surgical management in adults with supratentorial intermediate or high-grade astrocytomas. Earlier reports are included because they are repeatedly referenced in current works and clearly are an important basis upon which present attitudes are predicated. Because recent work has definitively demonstrated the significance of prognostic variables on outcome, the handling of such factors in studies that investigated survival data according to degree of surgery is emphasized. Study design, experimental methods used, and methods of data analysis are also examined. This analysis shows that there is little justification for dogmatic statements concerning the relationship between increasing patient survival times and aggressive surgical management in adults with supratentorial intermediate or high-grade astrocytomas, if patients receive postoperative radiotherapy.
Nazzaro
J M
JM
Department of Neurosurgery, Oregon Health Sciences University, Portland.
Neuwelt
E A
EA
D000328:Adult; D003627:Data Interpretation, Statistical; D005909:Glioblastoma / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D006801:Humans; D011379:Prognosis; D012107:Research Design; D015173:Supratentorial Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D015996:Survival Rate