title: In vitro prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes.
abstract: Glioblastoma cells constitutively produce various amounts of PGE2 (prostaglandin E2) in vitro. The amounts of PGE2 found in the conditioned medium of the glioblastoma cultures (less than 5 ng/ml) were not enough to inhibit the IL-2 (interleukin-2) activation of peripheral blood lymphocytes. However the amount of PGE2 produced by approximately 1 x 10(7) of the glioblastoma cells can be assumed to suppress the generation of IL-2-induced killing activity against glioblastoma cells.
authors.affiliation: Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawamura
authors.forename: A C
authors.initials: AC
authors.lastname: Diserens
authors.forename: N
authors.initials: N
authors.lastname: de Tribolet
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism*; D003470:Culture Media; D015232:Dinoprostone / Q000096:biosynthesis* / Q000502:physiology; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors*; D015979:Killer Cells, Lymphokine-Activated / Q000502:physiology*; D011863:Radioimmunoassay; D014407:Tumor Cells, Cultured
chemical_list: D003470:Culture Media; D007376:Interleukin-2; D015232:Dinoprostone