title: Dilevalol: an overview of its clinical pharmacology and therapeutic use in hypertension.
abstract: Dilevalol is a novel antihypertensive drug that combines nonselective beta blockade with selective beta 2-receptor agonist activity. Its antihypertensive effect is mediated through arterial vasodilation and a decrease in systemic vascular resistance. At rest, dilevalol has little effect on heart rate or cardiac output. The drug is rapidly and completely absorbed but undergoes significant first-pass hepatic extraction. Its elimination half-life of approximately 12 hours allows for once-daily administration. In controlled clinical trials, dilevalol was at least as effective as angiotensin-converting enzyme inhibitors and comparable to beta blockers in antihypertensive efficacy. Preliminary data indicate that dilevalol reverses left ventricular hypertrophy in some patients. It does not adversely affect renal function and may have a favorable effect on plasma lipids, especially high-density lipoprotein cholesterol. The agent is usually well tolerated and may prove to be a useful addition to our antihypertensive drugs.
authors.affiliation: Department of Clinical Pharmacy, University of Tennessee, Memphis.
authors.forename: R L
authors.initials: RL
authors.lastname: Lalonde
authors.forename: D M
authors.initials: DM
authors.lastname: Tenero
authors.forename: D J
authors.initials: DJ
authors.lastname: Kazierad
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007741:Labetalol / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D010656:Phenylephrine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D008055:Lipids; D011941:Receptors, Adrenergic; D010656:Phenylephrine; D007741:Labetalol