title: Oxygen radical scavenging activity of phenylbutenones and their correlation with antiinflammatory activity.
abstract: A number of ring substituted(E)-4-phenyl-3-buten-2-ones including dehydrozingerone were studied for their oxygen radical scavenging properties. They scavenged superoxide and hydroxyl radicals to an appreciable extent. Good correlation (r = 0.87) was obtained between superoxide scavenging and antiinflammatory activity. The correlation was not significant with the hydroxyl scavenging activity.
authors.affiliation: College of Pharmaceutical Sciences, Manipal, India.
authors.forename: L A
authors.initials: LA
authors.lastname: Saldanha
authors.forename: G
authors.initials: G
authors.lastname: Elias
authors.forename: M N
authors.initials: MN
authors.lastname: Rao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002074:Butanones / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012044:Regression Analysis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides