title: Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.
abstract: Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.
authors.affiliation: Institute of Neurology, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Salvi
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: R
authors.initials: R
authors.lastname: Plasmati
authors.forename: G
authors.initials: G
authors.lastname: Rubboli
authors.forename: F
authors.initials: F
authors.lastname: Cirignotta
authors.forename: M
authors.initials: M
authors.lastname: Veilleux
authors.forename: E
authors.initials: E
authors.lastname: Lugaresi
authors.forename: C A
authors.initials: CA
authors.lastname: Tassinari
mesh_terms: D000368:Aged; D000682:Amyloid / Q000235:genetics*; D000686:Amyloidosis / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000235:genetics*; D010292:Paresthesia / Q000235:genetics; D010375:Pedigree; D010523:Peripheral Nervous System Diseases / Q000235:genetics*; D011228:Prealbumin / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D013577:Syndrome
chemical_list: D000682:Amyloid; D005819:Genetic Markers; D011228:Prealbumin; C041120:amyloid prealbumin