Antibody against EBV in CSF from HIV-1 and HTLV-I infected patients.
We have measured the levels of antibody (ab) against different Epstein-Barr virus (EBV) antigens in 10 AIDS patients, 7 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and 20 control subjects. We found comparable serum levels of anti-EBV ab between AIDS patients, HAM/TSP patients and control subjects. By contrast, anti-EBV ab were present in the large majority of CSF from AIDS patients (70%) and HAM/TSP patients (60%) but only in 15% of control group. Our results support a synergistic role of EBV in retroviral infections of the central nervous system.
Martino
G V
GV
Clinica Neurologica IV, Università di Milano.
Grimaldi
L M
LM
Moiola
L
L
Cichero
P
P
Ieri
R
R
Bonini
P A
PA
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D015497:HIV-1; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000134:cerebrospinal fluid* / Q000276:immunology
D000914:Antibodies, Viral