title: Anginal attack following a sodium bicarbonate and hydrocortisone injection.
abstract: A case of a 73-year-old man with variant angina who developed chest pain and shock following an injection of sodium bicarbonate and hydrocortisone is reported. The electrocardiogram (ECG) during the chest pain attack revealed ST elevation in leads II, III and aVF. It returned to a normal pattern 10 min later. Coronary angiography, performed 2 hours after the anginal attack, showed no significant coronary arterial stenosis. One month later, an injection of ergonovine (16 micrograms) into the right and left coronary arteries induced spasms in segments 4 and 13, with ischemic ECG changes. Possible causes of the anginal attack are a coronary arterial spasm induced by the allergic reaction to hydrocortisone and/or serum alkalosis due to the sodium bicarbonate injection triggered by hyperventilation.
authors.affiliation: Department of Internal Medicine, Fukui Cardiovascular Center, Japan.
authors.forename: D J
authors.initials: DJ
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Mifune
authors.forename: K
authors.initials: K
authors.lastname: Taga
authors.forename: S
authors.initials: S
authors.lastname: Hifumi
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Yamashida
authors.forename: S
authors.initials: S
authors.lastname: Nishioka
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000503:physiopathology; D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects*; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced*; D004244:Dizziness / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology*; D004562:Electrocardiography; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D007275:Injections, Intravenous; D008297:Male; D012964:Sodium / Q000008:administration & dosage / Q000009:adverse effects*; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone