Haemopoietic receptors and helical cytokines.
A bewitching interplay of proteins, variously clothed as chemical messengers and cellular receptors, control the pace of growth and the course of progressive differentiation in blood cell types. The messengers are lymphokines, interleukins, colony-stimulating factors, growth hormones and interferons: generically, the cytokines. The second components of the regulatory pairs are membrane-spanning receptor proteins: these molecules transduce the specific binding of cognate cytokines into a mitogenic cellular response. In this article, Fernando Bazan discusses a provocative structural model for cytokine-receptor interactions which, if correct, will alter perceptions of the evolutionary design of the haemopoietic system.
Bazan
J F
JF
Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143-0448.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D008961:Models, Structural; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
D016207:Cytokines; D011956:Receptors, Cell Surface