Effect of primary Epstein-Barr virus infection on human herpesvirus 6, cytomegalovirus, and measles virus immunoglobulin G titers.
Immunoglobulin G antibody titers to human herpesvirus 6 (HHV-6), measles virus, and cytomegalovirus (CMV) were examined in serum samples from 31 patients with Epstein-Barr virus (EBV)-induced infectious mononucleosis (IM). Sera were drawn sequentially from the same patients less than or equal to 7 days until 3 years after onset of IM. In seropositive patients, there was a significant decrease with time after IM of the immunoglobulin G titers to the three viruses in the majority of patients; HHV-6 IgG titers decreased in 80%, measles virus IgG titers decreased in 75%, and CMV IgG titers decreased in 67%. Four patients contracted CMV infection during the observation period after IM. In these, HHV-6 IgG titers increased, while EBV and measles virus IgG titers remained essentially stationary. Polyclonal B-cell stimulation during IM is suggested to augment antiviral titers in general, but the increases of HHV-6 IgG titers during EBV and CMV infections may also be due to selective stimulation of memory B cells by related antigens or to reactivation of HHV-6 during infection with these herpesviruses.
Linde
A
A
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
Fridell
E
E
Dahl
H
H
Andersson
J
J
Biberfeld
P
P
Wahren
B
B
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000378:metabolism*; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D015654:Herpesvirus 6, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007244:Infectious Mononucleosis / Q000276:immunology*; D008297:Male; D008459:Measles virus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G