Immunohistochemical localization of factor X-like antigen in pancreatic islets and their tumours.
The authors have investigated by immunohistochemistry the distribution of factor X-like antigen in normal pancreatic islets and in a series of 46 pancreatic endocrine tumours. It was found that both glucagon-producing (A) cells and pancreatic polypeptide-producing (PP) cells are immunoreactive for the antigen. Benign glucagonomas and PP-omas presented the highest concentrations of immunoreactive material whose intracellular distribution was consistent with localization within cell secretory granules. Some benign insulinomas also presented factor X immunostaining in spite of the absence of the antigen in normal insulin-producing B cells. Although malignant tumours usually exhibited very low or no immunostaining, two of three malignant glucagonomas showed scattered, intensely immunoreactive cells. The factor X-like antigen identified in this study was found to differ from chromogranin A and B. The possible implications of the present findings for coagulative disorders associated with glucagonomas or diabetes are discussed.
Bordi
C
C
Institute of Pathological Anatomy, University of Parma, Italy.
Yu
J Y
JY
Girolami
A
A
Betterle
C
C
D007516:Adenoma, Islet Cell / Q000032:analysis*; D000941:Antigens / Q000032:analysis*; D005170:Factor X / Q000032:analysis*; D006801:Humans; D007340:Insulinoma / Q000032:analysis*; D007515:Islets of Langerhans / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000032:analysis*; D010191:Pancreatic Polypeptide / Q000032:analysis
D000941:Antigens; C010515:factor X antigen; D010191:Pancreatic Polypeptide; D005170:Factor X