[99mTc-MAG3 and 131I-OIH in patients with kidney insufficiency and with normal kidneys].
Renal clearance of 99mTc-mercaptoacetyltriglycine (MAG3) and 131J-orthoidohippurate (OIH) were compared by simultaneous measurement in 50 patients. Renal time-activity-curves of both radiopharmaceuticals were compared in 50 patients. With regard to the clearance, good correlation (r = 0.95) with a mean ratio MAG3-/OIH-clearance of 0.62 was found. No significant difference between patients with normal (n = 30) and impaired (n = 20) renal function could be demonstrated. Renal time activity curves and relative renal function showed good correspondence in patients with normal (n = 13) and impaired (n = 7) renal function. It is concluded that MAG3 may be used as substitute for OIH in patients with normal and impaired renal function.
Keske
U
U
Abteilung für Innere Medizin mit Schwerpunkt Nephrologie, Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Berlin, West.
Cordes
M
M
Wilfling
M
M
Hunger
J
J
Hosten
N
N
Gahl
G
G
D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000493:pharmacokinetics*; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000378:metabolism*; D009842:Oligopeptides / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011866:Radioisotope Renography; D013667:Technetium; D017263:Technetium Tc 99m Mertiatide
D007457:Iodine Radioisotopes; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide; D013667:Technetium
99mTc-MAG3 und 131J-OIH bei niereninsuffizienten und nierengesunden Patienten.