Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome. Evidence of Epstein-Barr virus infection and B-cell clonal selection without myc rearrangement.
A case of lymphomatoid granulomatosis of lung that occurred in a patient with the acquired immunodeficiency syndrome (AIDS) was studied by light microscope, electron microscope, cell surface markers, and Southern blot test. Clonal selection of two clones of B-cells was seen. Two clones were infected with Epstein-Barr virus. There was no c-myc rearrangement. Lymphomatoid granulomatosis in patients with AIDS may represent multiclonal selection of B-lymphocytes in association with Epstein-Barr virus infection.
Mittal
K
K
Department of Pathology, New York University School of Medicine, Bellevue Hospital, NY 10016.
Neri
A
A
Feiner
H
H
Schinella
R
R
Alfonso
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D015321:Gene Rearrangement; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008297:Male; D009857:Oncogenes
D004279:DNA, Viral