Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid.
Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may be useful tools for investigating the role of zinc in central nervous system excitatory transmission and/or convulsive phenomena.
Mitchell
C L
CL
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Barnes
M I
MI
Grimes
L M
LM
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D004230:Dithizone / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology / Q000031:analogs & derivatives; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D015032:Zinc / Q000378:metabolism*
D001391:Azo Compounds; D002614:Chelating Agents; D004230:Dithizone; D004050:Ditiocarb; C039353:dihydroxyethyldithiocarbamate; D015032:Zinc; D007608:Kainic Acid