Radiation therapy for paragangliomas of the temporal bone.
Treatment of paragangliomas of the temporal bone (glomus jugulare and glomus tympanicum tumors) is controversial, with both surgery and radiation therapy having their advocates. This paper discusses the experience at the University of Arizona Health Sciences Center in treating 10 cases of this uncommon tumor between 1971 and 1988. Seven of 10 cases were initially treated using irradiation and achieved complete tumor control for a mean of 67 months (range = 23-107 months). Two patients, one treated surgically and the other by embolization, had recurrences and were salvaged by radiation, and neither has recurred. The final patient is disease-free 9 months after embolization and surgery. There have been no serious sequelae of treatment. We conclude that moderate-dose irradiation can safely control most temporal bone paragangliomas.
Boyle
J O
JO
College of Medicine, Department of Radiation Oncology, University of Arizona Health Science Center, Tucson 85724.
Shimm
D S
DS
Coulthard
S W
SW
D005260:Female; D005500:Follow-Up Studies; D005925:Glomus Jugulare Tumor / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000401:mortality / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012888:Skull Neoplasms / Q000401:mortality / Q000532:radiotherapy; D015996:Survival Rate; D013701:Temporal Bone; D013997:Time Factors