title: Full spectral GC/MS identification of delta 9-carboxy-tetrahydrocannabinol in urine with the Finnigan ITS40.
abstract: The Finnigan MAT ITS40 GC/MS permits the accurate full mass spectral identification and reproducible quantitation of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (9-carboxy-THC) in urine. Positive identification of 9-carboxy-THC is based on full mass spectral cutoff criteria whose fit value is 900. The fit value is generated from a statistically significant correlation comparison of the targeted unknown against an authentic 9-carboxy-THC standard, whose mass spectrum has been generated on the ITS40. The limit of detection (LOD) and limit of quantitation (LOQ) are 2.5 ng/mL and 5 ng/mL, respectively, using 5 mL of urine. The quantitative linear dynamic range of the assay is greater than two orders of magnitude, ranging from 5 to 1,000 ng/mL.
authors.affiliation: Department of Pathology, Texas College of Osteopathic Medicine, Fort Worth 76107.
authors.forename: G H
authors.initials: GH
authors.lastname: Wimbish
authors.forename: K G
authors.initials: KG
authors.lastname: Johnson
mesh_terms: D013759:Dronabinol / Q000031:analogs & derivatives* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation; D006801:Humans; D006868:Hydrolysis; D015813:Substance Abuse Detection
chemical_list: D013759:Dronabinol; C025351:delta(9)-tetrahydrocannabinolic acid