Effects of chronic treatment with cadmium on ATPases, uptake of catecholamines, and lipid peroxidation in rat brain synaptosomes.
The chronic effects of cadmium on specific activities of oligomycin-sensitive (OS) and -insensitive Mg2+ ATPase, Na(+)-K+ ATPase, lipid peroxidation, and uptake of catecholamines in brain synaptosomes of rats treated daily for 2 or 4 months were studied. Cadmium significantly decreased the specific activities of OS-Mg2+ ATPase, Na(+)-K+ ATPase, and uptake of [3H]-dopamine (3H-DA) and [3H]norepinephrine (3H-NE) and increased the lipid peroxidation.
Rajanna
B
B
Division of Natural Sciences, Selma University, Alabama 36701.
Hobson
M
M
Boykin
M
M
Chetty
C S
CS
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D002104:Cadmium / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013574:Synaptosomes / Q000201:enzymology / Q000378:metabolism; D014316:Tritium
D002104:Cadmium; D014316:Tritium; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine; D009638:Norepinephrine