[Expression of MG7 corresponding antigen in gastric polyp and its relation to gastric carcinoma].
Forty-nine cases of gastric polyp (GP) were studied by histologic classification and immunohistochemical localization of monoclonal antibody MG 7 against gastric carcinoma. There were 12 cases (24.5%) of inflammatory polyp; 19 cases (38.8%) of hyperplastic polyp and 18 cases (36.7%) of adenomatous polyp. 3 cases (6.1%) of GP were malignant, among which 2 (11.1%) were adenomatous polyp and 1 (5.3%) was hyperplastic polyp. Seventeen cases (34.7%) of GP were MG 7 positive by ABC method, including 7 (36.8%) of hyperplastic polyp and 10 (55.5%) of adenomatous polyp. The inflammatory polyps were negative, and all of the cases with malignancy were strongly positive. The results showed that both GP and gastric carcinoma express MG 7 related antigen. These suggest that adenomatous polyp and hyperplastic polyp are closely related with gastric carcinogenesis.
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D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D011127:Polyps / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm