Alternative splicing of mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA.
A second cDNA for mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase (cDNAII) encoding 420 amino acids was isolated. The only difference from the cDNA obtained previously (cDNAI), which encodes 400 amino acids, was the 5'-end 53 bp. Comparison of the sequence of the mouse gene with the sequence of cDNAII indicates alternative splicing within exon 1. The 5'-end sequence of cDNAII was found in a region of the gene upstream of exon 1 and a second transcription initiation site was identified.
Kurihara
T
T
Department of Neuropharmacology, Niigata University, Japan.
Monoh
K
K
Sakimura
K
K
Takahashi
Y
Y
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D004247:DNA / Q000235:genetics*; D005091:Exons; D015723:Gene Library; D051379:Mice; D008969:Molecular Sequence Data; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid
D004247:DNA; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases