Growth hormone gene regulation: a paradigm for cell-type-specific gene activation.
The growth hormone (GH) gene is specifically expressed within specialized cells of the anterior pituitary. The central role in GH gene activation is played by GHF-1, a homeodomain protein that is itself specifically expressed in the anterior pituitary.
Karin
M
M
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.
Castrillo
J L
JL
Theill
L E
LE
D000818:Animals; D005786:Gene Expression Regulation; D013006:Growth Hormone / Q000235:genetics*; D008322:Mammals; D008957:Models, Genetic; D010903:Pituitary Gland, Anterior / Q000196:embryology; D015533:Transcriptional Activation
D013006:Growth Hormone