title: Counting the costs of chemotherapy in a National Cancer Institute of Canada randomized trial in nonsmall-cell lung cancer.
abstract: An economic evaluation was undertaken of a previously reported National Cancer Institute of Canada (NCIC) trial of chemotherapy in advanced nonsmall-cell lung cancer (NSCLC). That trial had demonstrated a survival benefit associated with the use of either vindesine and cisplatin (VP) or cyclosphosphamide, doxorubicin, and cisplatin (CAP) in relation to best supportive care (BSC). The economic technique used in this evaluation was cost-effectiveness analysis (CEA). All costs were determined from the viewpoint of two provincial health care plans. When compared with BSC, the survival benefit of 8 weeks in favor of patients receiving CAP chemotherapy was associated with an economic saving of $949.49 (in 1984 Canadian dollars). This translated into a savings of $6,171.69 per year of life gained. The mean survival benefit of 12.8 weeks that was obtained with VP chemotherapy compared with BSC was associated with an increased cost of $3,637.60 per patient, or $14,777.75 per year of life gained. The economic evaluation demonstrated that the majority of costs on each of the three treatment arms was related to hospitalization and not to the use of chemotherapy agents. These results compare favorably with estimates of cost-effectiveness (CE) of commonly used treatments for other diseases and demonstrate that a policy of supportive care is associated with costs that may exceed those of active treatment. It is concluded that economic factors should not adversely affect decisions regarding the use of chemotherapy in advanced NSCLC.
authors.affiliation: Department of Preventive Medicine and Biostatistics, University of Toronto, Ontario, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Jaakkimainen
authors.forename: P J
authors.initials: PJ
authors.lastname: Goodwin
authors.forename: J
authors.initials: J
authors.lastname: Pater
authors.forename: P
authors.initials: P
authors.lastname: Warde
authors.forename: N
authors.initials: N
authors.lastname: Murray
authors.forename: E
authors.initials: E
authors.lastname: Rapp
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002170:Canada; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000191:economics; D002945:Cisplatin / Q000008:administration & dosage; D003362:Cost-Benefit Analysis; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006077:Government Agencies; D006760:Hospitalization / Q000191:economics; D006801:Humans; D008020:Life Support Care / Q000191:economics; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000191:economics; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D014751:Vindesine