New perspectives in the treatment of hypoxic and ischemic brain damage: effect of gangliosides.
Aircrews operating at high G forces and altitudes may be exposed to both physiological and physical stresses capable of inducing brain hypoxia. A potential therapeutic tool for the treatment of flight personnel, monosialoganglioside (GM1) has been found to reduce deficits and enhance repair following CNS injury. A survey of experimental evidence concerning the effects of GM1 in the acute phase of CNS injury supports its proposed application for aerospace medicine.
Rotondo
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Postgraduate School of Aerospace Medicine, University of Rome, Italy.
Maniero
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Toffano
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D000818:Animals; D001925:Brain Damage, Chronic / Q000628:therapy*; D005677:G(M1) Ganglioside / Q000008:administration & dosage*; D006112:Gravitation; D006801:Humans; D002534:Hypoxia, Brain / Q000628:therapy*; D009416:Nerve Regeneration / Q000187:drug effects; D013026:Space Flight
D005677:G(M1) Ganglioside