[The role of the thrombocyte-activating factor in the development of circulatory disorders in the postischemic shock reaction].
Experiments carried out on anesthetized dogs have shown that reperfusion of long-ischemized leg tissues is accompanied by a significant decrease of the cardiac output and myocardial contractility. Restriction of the venous return to the heart is important in the cardiac output decrease due to an increase of venous compliance and blood pooling on the peripheral circulation. The preliminary blockade of platelet-activating factor (PAF) receptors decreases degree of the cardio- and hemodynamic disturbances after reperfusion of ischemized tissues and prevents development of pulmonary hypertension. Similarity of the postreperfusion central and peripheral hemodynamic disturbances and animal responses to injection of the exogenous PAF as well as the presence of the protective effect of PAF-receptor antagonist BNo. 52021 permit concluding, that PAF takes part in the development of postischemic shock reaction and its receptor blockade can be used to prevent postreperfusion hemodynamic disorders.
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D000818:Animals; D004224:Diterpenes; D004285:Dogs; D046934:Ginkgolides; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006614:Hindlimb / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology; D007783:Lactones / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000502:physiology; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D015424:Reperfusion; D012769:Shock / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors; D014111:Tourniquets
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; C045856:ginkgolide B
Rol' trombotsitaktiviruiushchego faktora v razvitii narusheniĭ krovoobrashcheniia pri postishemicheskoĭ shokovoĭ reaktsii.