[Is xanthine oxidase a universal source of superoxide radicals in ischemic and reperfusion lesions?].
While studying xanthine-xanthine oxidase system it was found, that a considerable accumulation of xanthine and uric acid occurred whereas xanthine dehydrogenase did not transfer in xanthine oxidase during 2 hours of total rat liver ischemia. These data make it possible to reject the generally accepted hypothesis of xanthine oxidase key role in free radical mechanism of ischemia damage.
Rashba
Iu E
IuE
Nagler
L G
LG
Vartanian
L S
LS
Oktiabr'skaia
L A
LA
Bilenko
M V
MV
D000818:Animals; D002845:Chromatography; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007511:Ischemia / Q000201:enzymology*; D008099:Liver / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D015424:Reperfusion; D013481:Superoxides / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism; D019820:Xanthine; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*; D014970:Xanthines / Q000378:metabolism
D005609:Free Radicals; D007042:Hypoxanthines; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase
Iavliaetsia li ksantinoksidaza universal'nym istochnikom superoksidnykhradikalov pri ishemicheskom i reperfuzionnom povrezhdeniiakh?