Anaemia of chronic disease: diagnostic significance of erythrocyte and serological parameters in iron deficient rheumatoid arthritis patients.
Erythrocyte and serological parameters were assessed in 44 anaemic rheumatoid arthritis (RA) patients to detect iron deficiency as assessed by stainable bone marrow iron. The anaemia was normochromic normocytic in 60% and hypochromic normocytic in 30% of those with anaemia of chronic disease (ACD). Iron deficiency was present in 55% and the anaemia was hypochromic microcytic in 54% and hypochromic normocytic or normochromic normocytic in 21%. Iron absorption was found to be higher in iron deficient patients. In ACD patients, iron absorption correlated inversely with ESR and CRP. For the detection of iron deficiency among RA patients with ACD, the MCV showed the highest specificity (90%) and predictive value (87%). Serum ferritin was the most sensitive (82%) and valid (86%) test. Combination of MCV, ferritin and transferrin resulted in 100% validity. It was concluded that iron deficiency can be detected accurately without bone marrow aspiration using combinations of blood parameters.
Vreugdenhil
G
G
Zuiderziekenhuis, Department of Internal Medicine, Rotterdam, The Netherlands.
Baltus
C A
CA
van Eijk
H G
HG
Swaak
A J
AJ
D000747:Anemia, Hypochromic / Q000097:blood / Q000175:diagnosis*; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001799:Blood Sedimentation; D001853:Bone Marrow / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D011336:Probability; D012680:Sensitivity and Specificity
D006454:Hemoglobins; D002097:C-Reactive Protein; D005293:Ferritins; D006485:Hemosiderin; D007501:Iron