N-[18F]fluoro-N-alkylsulfonamides: novel reagents for mild and regioselective radiofluorination.
N-[18F]fluoro-N-alkylsulfonamides were synthesized by the fluorination of secondary sulfonamides with [18F]F2. Radiochemical yields up to 45% (out of a maximum possible yield of 50%) for these reactions have been realized. The N-[18F]fluorosulfonamides rapidly and regiospecifically fluorinate a variety of Grignard reagents and aryllithium under very mild conditions to give 18F-labeled derivatives in good yields.
Satyamurthy
N
N
Department of Radiological Sciences, UCLA School of Medicine 90024.
Bida
G T
GT
Phelps
M E
ME
Barrio
J R
JR
D005461:Fluorine; D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000379:methods; D013449:Sulfonamides / Q000138:chemical synthesis*
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D013449:Sulfonamides; D005461:Fluorine