title: [The regulation of Na, K-ATPase activity by the substrate].
abstract: The mechanism of functioning of Na, K-ATPase system is considered, the peculiarities of hydrolysis in different substrates are described. The experimental results testify to the role of substrate structure in E2----E1-transition, Na+ transport, K(+)-dependent phosphatase activity and quaternary structure of enzyme. The regulatory role of molecular organization of Na, K-ATPase in ion transport is discussed.
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
authors.forename: O D
authors.initials: OD
authors.lastname: Lopina
authors.forename: N U
authors.initials: NU
authors.lastname: Fedosova
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006868:Hydrolysis; D008970:Molecular Weight; D009711:Nucleotides / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity / Q000502:physiology
chemical_list: D009711:Nucleotides; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Reguliatsiia aktivnosti Na, K-ATFazy substratom.