title: A model for determining immunogenic relationships between avian infectious bronchitis viruses.
abstract: A model for determining immunogenic relationships between strains of infectious bronchitis virus is described that is based upon the vaccinating dose required to induce prevention of multiplication of a standard challenge dose of an homologous strain in the lungs of specific-pathogen-free chickens. The model has been used to demonstrate that: (1) Approximately 100 times the vaccinating dose must be used to produce immunity from one compared with two doses; (2) differences of immunogenicity of greater than 1,000-fold exist between Australian strains; (3) immunogenicity is greatest for live virus administered directly to the trachea, followed by live virus administered by the ocular route, inactivated virus administered intratracheally and inactivated virus administered intramuscularly; (4) for chickens inoculated with Australian vaccine strains, protection against challenge is unrelated to serotype.
authors.affiliation: Faculty of Medicine, University of Newcastle, N. S. W., Australia.
authors.forename: Y
authors.initials: Y
authors.lastname: Arvidson
authors.forename: G A
authors.initials: GA
authors.lastname: Tannock
authors.forename: A
authors.initials: A
authors.lastname: Senthilselvan
authors.forename: M
authors.initials: M
authors.lastname: Zerbes
mesh_terms: D000375:Aging; D000818:Animals; D002642:Chick Embryo; D003332:Coronaviridae / Q000276:immunology*; D003429:Cross Reactions; D001351:Infectious bronchitis virus / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D008168:Lung / Q000382:microbiology; D008954:Models, Biological; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D014765:Viral Vaccines