[Na-pump regulation by liponucleotides:its mechanism and physiological significance].
A short-term regulation of Na,K-ATPase by the long-chain fatty acid esters and coenzyme A (liponucleotides) has been studied. It has been found that in the presence of liponucleotides the maximum velocity of ATP-hydrolysis doesn't change, but the apparent KM value decreases. While studying the ion transport it has been shown that palmitoyl-CoA stimulates the pump approaching the cell membrane from the cytoplasmic side, being an intracellular regulator of Na,K-ATPase. A possible mechanism of liponucleotide action on the process of enzyme functioning and its physiological implications is discussed.
Askari
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D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D003065:Coenzyme A / Q000494:pharmacology* / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005227:Fatty Acids / Q000494:pharmacology* / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
D005227:Fatty Acids; D015222:Sodium Channels; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D003065:Coenzyme A
Reguliatsiia Na-nasosa liponukleotidami: mekhanizm i fiziologicheskoe znachenie.