Effect of aflatoxins on rat peritoneal macrophages.
Phagocytosis, intracellular killing of Candida albicans, and superoxide production by rat peritoneal macrophages exposed to aflatoxins B1, B2, G1, G2, B2a, and M1 at several times and concentrations were analyzed to evaluate the intensity of a depressive effect for each mycotoxin. All aflatoxins used at very low concentrations had a depressive effect on the functions of macrophages. The biggest impairment of phagocytosis, intracellular killing, and spontaneous superoxide production was observed in macrophages exposed to aflatoxins B1 and M1.
Cusumano
V
V
Microbiology Institute, Medical School, University of Messina, Italy.
Costa
G B
GB
Seminara
S
S
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D002176:Candida albicans / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000348:Aflatoxins; D013481:Superoxides; D013755:Tetradecanoylphorbol Acetate