Transmissible trimethoprim resistance in strains of Escherichia coli isolated from cases of infantile diarrhoea.
Of 190 isolates of Escherichia coli from children aged up to 5 years with diarrhoea, 72 (37.9%) were resistant to trimethoprim and of the 70 isolates tested, 38 transferred high level trimethoprim resistance (MIC greater than 1000 mg/L) into E. coli EC 1005. Of the enterotoxigenic isolates from which trimethoprim resistance was transferred, 41.2% also contained transmissible toxigenic characteristics. All the trimethoprim-resistant isolates were resistant to other antibiotics.
Lamikanra
A
A
Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Ako-Nai
A K
AK
Ola
J B
JB
D002675:Child, Preschool; D003227:Conjugation, Genetic; D004251:DNA Transposable Elements; D003968:Diarrhea, Infantile / Q000382:microbiology*; D004926:Escherichia coli / Q000302:isolation & purification*; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D014296:Trimethoprim Resistance / Q000235:genetics*
D004251:DNA Transposable Elements; D005819:Genetic Markers