Effects of intraarterial chemotherapy using the new lipophilic anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol on Walker 256 carcinosarcoma in Wistar rats--a preliminary report.
The effect of a new oil-soluble anticancer agent 'KM2210' (estradiol-chlorambucil) dissolved in lipiodol (LPD) was investigated as intraarterial chemotherapy, using 40 Wistar rats bearing Walker 256 carcinosarcoma in the extremities. KM2210-LPD significantly inhibited tumor growth and prolonged the survival time, as compared to LPD alone or saline alone, p less than 0.01 and p less than 0.01, respectively. Pathological study revealed that KM2210-LPD made the tumor necrotic. It was revealed that KM2210-LPD injected into the femoral artery was retained in the hind limb tumor. These findings suggest that KM2210 may possibly become a new anticancer agent with potential clinical use in LPD chemoembolization.
Egawa
H
H
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Mori
K
K
Mitsuhashi
S
S
Bannai
K
K
Asano
K
K
Ozawa
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002296:Carcinosarcoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005121:Extremities; D005260:Female; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000378:metabolism*; D009336:Necrosis; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions
D000970:Antineoplastic Agents; D012996:Solutions; D002699:Chlorambucil; D004958:Estradiol; C036613:bestrabucil; D007459:Iodized Oil