Complex rearrangement of the T cell receptor in large granular lymphocytosis associated with myeloid suppression.
A patient is described with neutropenia associated with large granular lymphocyte proliferation, whose peripheral blood cells were analyzed with the beta chain gene probe of the T cell receptor (TCR). The pattern of rearrangement of the TCR was unusually complex, and apparently involved rearrangement of both J beta 1 loci with upstream V beta segments and of both J beta 2 loci with a downstream V beta by inversion. This case represents a unique pattern of rearrangement of the beta-chain of TCR. These results suggest caution in estimating the number of clones present in apparent oligoclonal proliferations.
Platanias
L C
LC
Department of Medicine, Pritzker School of Medicine, University of Chicago, Illinois 60637-1470.
Larson
R A
RA
Vardiman
J W
JW
Reisel
H
H
Golomb
H M
HM
McKeithan
T W
TW
D000293:Adolescent; D015139:Blotting, Southern; D002455:Cell Division; D004247:DNA / Q000302:isolation & purification; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008218:Lymphocytosis / Q000150:complications / Q000235:genetics*; D009503:Neutropenia / Q000150:complications / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000502:physiology* / Q000648:ultrastructure
D011948:Receptors, Antigen, T-Cell; D004247:DNA