Treatment of chancroid with spectinomycin or co-trimoxazole.
Chancroid, the third most prevalent venereal disease in Thailand, was treated with a single 2-gm dose of spectinomycin, or two tablets of co-trimoxazole (trimethoprim-sulfamethoxazole) twice daily for seven days. The differences in cure rates between the two groups were statistically significant. The chancroidal ulcers were cured in 93.7% of 175 patients treated with spectinomycin, and in 48.2% of 168 co-trimoxazole-treated patients (P less than 0.01). The in vitro susceptibility of Haemophilus ducreyi to spectinomycin was 4 to 16 micrograms/ml and to co-trimoxazole 32 micrograms/ml or higher. Thus we found that a single-dose regimen of spectinomycin was significantly more effective than the standard seven-day regimen of co-trimoxazole for the treatment of chancroid.
Traisupa
A
A
Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand.
Ariyarit
C
C
Metheeprapha
C
C
Buatiang
A
A
Sungthong
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D002602:Chancroid / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D002692:Chlamydia trachomatis; D006191:Haemophilus ducreyi; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D018139:Simplexvirus; D000198:Spectinomycin / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000198:Spectinomycin