A distinctive family of embryonic protein-tyrosine kinase receptors.
Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.
Pasquale
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EB
Department of Biology, University of California, San Diego, La Jolla 92093.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002642:Chick Embryo; D015723:Gene Library; D006133:Growth Substances / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D006133:Growth Substances; D007527:Isoenzymes; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases