[The mechanism of the effect of interleukin-1 on the glucocorticoid level of the blood: the absence of a direct action of interleukin-1 on adrenal cortex cells].
The investigation is devoted to the problem of interaction of the body neuroendocrine and immune systems. A study was made of possible mechanisms of stimulating action of IL-1, a cellular mediator of the immune system, on glucocorticoid function of the hypothalamic-pituitary-adrenocortical system. RIA and fluorescence methods as well as methods for obtaining IL-1 from activated rabbit leukocytes were employed. IL-1 was shown to increase the plasma level of corticosterone in rats in ip administration. It also produced a direct effect on the secretion of adrenal cells without enhancing ACTH stimulating action on them. The results of the investigation and literature data show that IL-1 action on the hypothalamic-pituitary-adrenocortical system is implemented through its influence on neurons of the cerebral hypothalamic areas secreting the corticotropin releasing factor.
Rybakina
E G
EG
Salai
K
K
Korneva
E A
EA
Shkhinek
E K
EK
Lesnikova
M P
MP
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000097:blood*; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015383:Zona Fasciculata / Q000187:drug effects / Q000378:metabolism; D015384:Zona Glomerulosa / Q000187:drug effects / Q000378:metabolism
D005938:Glucocorticoids; D007375:Interleukin-1; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
K mekhanizmu vliianiia interleĭkina-1 na uroven' gliukokortikoidov v krovi: otsutstvie priamogo deĭstviia interleĭkina-1 na kletki kory nadpochechnikov.