Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae.
6-Cyano-5-methoxy-12-methylindolo[2,3-alpha]carbazole and 6-cyano-5-methoxyindolo[2,3-alpha]carbazole are responsible for most of the cytotoxicity and antiviral activity associated with the blue-green alga Nostoc sphaericum EX-5-1. The compounds are active against HSV II and show weak cytotoxicity against KB and LoVo human carcinoma cell lines.
Knübel
G
G
Department of Chemistry, University of Hawaii, Honolulu 96822.
Larsen
L K
LK
Moore
R E
RE
Levine
I A
IA
Patterson
G M
GM
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D000458:Cyanobacteria / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018139:Simplexvirus / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D002227:Carbazoles; D003603:Cytotoxins; D007211:Indoles; C066545:6-cyano-5-methoxy-12-methylindolo(2,3-a)carbazole; C066546:6-cyano-5-methoxyindolo(2,3-a)carbazole