Diverse patterns of immune and non-immune-mediated disease in EMC M-variant-infected mice.
The M variant of EMC virus exhibits unique tropism for the beta cells of the islets of Langerhans. However, the severity and character of the lesion differ in various strains of animals. This paper briefly reviews the features of these lesions and considers their pathogenesis.
Craighead
J E
JE
Department of Pathology, University of Vermont, Burlington 05405.
Huber
S A
SA
Haynes
M K
MK
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000150:complications* / Q000473:pathology; D007515:Islets of Langerhans / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D013045:Species Specificity