[The effect of glycine and gamma-aminobutyric acid on the excitatory postsynaptic potentials of the spinal motor neurons in the lamprey in the presence of antagonists].
Effect of bath application of the inhibitory amino acids (glycine and GABA) on motoneurons of EPSPs was studied in the normal physiological solutions and after preliminary administration of antagonists: strychnine (10(-6) mol/l), bicuculline (10(-4) mol/l) or picrotoxin (10(-4) mol/l). All these antagonists diminished the depression of monosynaptic EPSPs which were elicited by both amino acids (glycine and GABA). Data obtained in this study and previously reported ones permit concluding that motoneuron membranes in the spinal cord of lamprey possess the unit receptor channel complex sensitive to both amino acids.
Batueva
I V
IV
Suderevskaia
E I
EI
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005399:Fishes / Q000502:physiology*; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D066298:In Vitro Techniques; D007798:Lampreys / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology; D010852:Picrotoxin / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D001640:Bicuculline; D018756:GABA Antagonists; D005998:Glycine; D010852:Picrotoxin; D017981:Receptors, Neurotransmitter; D013331:Strychnine; D005680:gamma-Aminobutyric Acid
Vliianie glitsina i gamma-aminomaslianoĭ kisloty na vozbuzhdaiushchie postsinapticheskie potentsialy spinal'nykh motoneĭronov minogi v prisutstvii antagonistov.