Effects of helodermin on fetal rat bone metabolism in vitro.
Helodermin belongs to the VIP family of polypeptides. Recent in vivo data suggest that helodermin-like peptides might be involved in the regulation of calcium metabolism. We show that helodermin specifically binds to a secretin-type receptor in osteoblast-like cells from fetal rat calvaria and increases the basal and PTH-stimulated cAMP concentration of these cells. In organ cultures of fetal rat calvaria, helodermin strongly inhibits bone matrix apposition and augments PTH-induced bone resorption. Helodermin-like peptides may thus be capable of enhancing the direct effects of PTH on bone metabolism.
Pfeilschifter
J
J
Department of Endocrinology and Metabolism, University of Heidelberg, West Germany.
Naumann
A
A
Oechsner
M
M
Ziegler
R
R
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004338:Drug Combinations; D005333:Fetus; D066298:In Vitro Techniques; D036341:Intercellular Signaling Peptides and Proteins; D010281:Parathyroid Hormone / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins; D010281:Parathyroid Hormone; D010455:Peptides; C040442:heliodermin; D000242:Cyclic AMP