[Carrier detection and prenatal diagnosis of Duchenne's muscular dystrophy based on DNA analysis].
Seven families with histories of Duchenne's muscular dystrophy underwent DNA diagnosis. The daughters of those consulted were examined for the carriage in 4 families. Their carriage was rejected or confirmed. Prenatal diagnosis was made in 2 families. In another family an abortion preceded obtaining molecular-genetic evidence. Probes 754, p20, XJI.I and primers for amplification of the site pERI87-15 containing a polymorphic locus were employed. The genetic risk was assessed using the computer program GenRisk adjusted for family history and DNA test allowances.
Evgrafov
O V
OV
Badalian
L O
LO
Poliakov
A V
AV
Zaĭtseva
S P
SP
Malygina
N A
NA
Vinogradov
S V
SV
Bakharev
V A
VA
Mil'man
F A
FA
Lisova
L P
LP
Zaretskaia
N V
NV
D000328:Adult; D000483:Alleles; D002648:Child; D015342:DNA Probes; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014960:X Chromosome / Q000648:ultrastructure
D015342:DNA Probes
Ustanovlenie nositel'stva i prenatal'naia diagnostika miodistrofii Diushenna na osnove analiza DNK.