Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri.
Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.
Geck
P
P
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Whitaker
S A
SA
Medveczky
M M
MM
Medveczky
P G
PG
D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003001:Cloning, Molecular; D003094:Collagen / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D015870:Gene Expression; D005814:Genes, Viral; D006567:Herpesvirus 2, Saimiriine / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D015678:Viral Structural Proteins / Q000235:genetics*
D004279:DNA, Viral; D012333:RNA, Messenger; D015678:Viral Structural Proteins; D003094:Collagen