title: Tolerance and complications in a multicenter trial of intravenous APSAC and intracoronary streptokinase in acute myocardial infarction.
abstract: Adverse events data of a randomized, multicenter, angiographically controlled trial of intracoronary streptokinase and intravenous anistreplase, or anisoylated plasminogen streptokinase activator complex (APSAC) are presented. The frequency of severe adverse events is similar for streptokinase and anistreplase; no unexpected adverse experiences were reported with either drug. The most frequently encountered side effect was bleeding, overwhelmingly from the groin puncture site from angiography.
authors.affiliation: University of Rochester School of Medicine, New York.
authors.forename: R L
authors.initials: RL
authors.lastname: Rothbard
authors.forename: J L
authors.initials: JL
authors.lastname: Anderson
authors.forename: P G
authors.initials: PG
authors.lastname: Fitzpatrick
authors.forename: R A
authors.initials: RA
authors.lastname: Hakworthy
authors.forename: S G
authors.initials: SG
authors.lastname: Sorensen
authors.forename: V J
authors.initials: VJ
authors.lastname: Marder
mesh_terms: D000208:Acute Disease; D000792:Angiography; D016255:Anistreplase; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000188:drug therapy*; D010958:Plasminogen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011677:Punctures / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D013300:Streptokinase / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D016255:Anistreplase; D010958:Plasminogen; D013300:Streptokinase