The rabbit jugular vein is a contractile NK-1 receptor system.
Rabbit isolated jugular veins respond to substance P and related neurokinins with concentration-dependent contractions which appears to be due to the activation of a single neurokinin receptor of the NK-1 type. This is demonstrated by the order of potency of neurokinins and some of their fragments as well as by the strong activity of NK-1-selective agonists and the weakness of NK-2- and NK-3-selective agonists. The present results indicate that the rabbit jugular vein provides a sensitive, specific and selective NK-1 preparation which responds directly to neurokinins with contractions and therefore can be useful for characterization of NK-1 agonists and antagonists.
Nantel
F
F
Department of Pharmacology, Medical School, University of Sherbrooke, Québec, Canada.
Rouissi
N
N
Rhaleb
N E
NE
Dion
S
S
Drapeau
G
G
Regoli
D
D
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D066298:In Vitro Techniques; D007601:Jugular Veins / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D009479:Neuropeptides / Q000494:pharmacology; D011817:Rabbits; D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D009479:Neuropeptides; D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D000804:Angiotensin II