[The sensitivity of the blood lymphocytes in stomach cancer patients to met-enkephalin, dopamine and serotonin].
Sensitivity of blood lymphocytes to the stimulating effect of met-enkephalin and dopamine was shown to decrease at late stages of the gastric cancer (IIIB-IV) or in the case of metastases to other organs, while to the inhibitory effect of serotonin it increased as compared to early stages (I-IIA). Using specific blockers of opioid, dopamine and serotonin receptors it was shown that these effects were mediated through stimulation of respective type receptors.
Kharkevich
D D
DD
Gubina
G I
GI
Kadagidze
Z G
ZG
D000328:Adult; D000368:Aged; D002628:Chemoreceptor Cells / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol; D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D009367:Neoplasm Staging; D011954:Receptors, Dopamine / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology
D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D011985:Receptors, Serotonin; D012701:Serotonin; D009270:Naloxone; D004744:Enkephalin, Methionine; D006220:Haloperidol; D004298:Dopamine; D008784:Methysergide
Chuvstvitel'nost' limfotsitov krovi bol'nykh rakom zheludka k met-énkefalinu, dofaminu i serotoninu.