Effects of thyroid hormone on angiotensinogen and renin messenger RNA levels in rats.
We studied the expression of angiotensinogen and renin genes in rats treated with 3,3',5-triiodo-L-thyronine (T3) at doses of 0.1 and 1 mg/kg of body weight. Liver angiotensinogen mRNA increased by 2 to 3 times 8 to 12 hours after T3-treatment. This increase was dose-related. Plasma angiotensinogen concentration (PAC) increased 12 hours after T3-treatment. Brain and renal angiotensinogen mRNA levels and the renal renin mRNA level remained the same throughout the experimental periods. These results suggest that the thyroid hormone initially increases angiotensinogen mRNA and leads to an increase in the production of angiotensinogen in the liver followed by an elevation of PAC.
Kimura
S
S
Department of Surgery, Kagawa Medical School, Japan.
Iwao
H
H
Fukui
K
K
Abe
Y
Y
Tanaka
S
S
D000808:Angiotensinogen / Q000235:genetics*; D000818:Animals; D001345:Autoradiography; D015152:Blotting, Northern; D015870:Gene Expression / Q000187:drug effects; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000235:genetics*; D014284:Triiodothyronine / Q000494:pharmacology*
D012333:RNA, Messenger; D014284:Triiodothyronine; D000808:Angiotensinogen; D012083:Renin