[Intra-arterial infusion of cisplatin and caffeine for a recurrent malignant fibrous histiocytoma].
We treated a 43-year-old man with recurrent malignant fibrous histiocytoma in right distal femur with intra-arterial infusion of cisplatin and caffeine 5 years after wide excision and chemotherapy. At the time of the first recurrence in the lateral aspect of thigh, intra-arterial infusion of CDDP (120 mg/m2) was ineffective. We treated him with radiation (7000 rad), and there was no evidence of tumor by radiological evaluation. The second local recurrence was treated with intra-arterial infusion of CDDP (120 mg/m2/1 hour) and caffeine (1.2 g/m2/24 hours x 3 days), and the tumor disappeared, radiologically and histologically. Caffeine did not increase the nephrotoxicity of CDDP, and no insomnia nor palpitation was seen. Intra-arterial infusion of CDDP and caffeine could be useful to increase the effect of CDDP for regional chemotherapy.
Tsuchiya
H
H
Dept. of Orthopedic Surgery, School of Medicine, Kanazawa University.
Tomita
K
K
Yasutake
H
H
Morishita
H
H
Morikawa
S
S
Ono
M
M
Tsuchida
T
T
Takagi
Y
Y
D000328:Adult; D002110:Caffeine / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D005266:Femoral Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*
D002110:Caffeine; D002945:Cisplatin