Ticarcillin/clavulanate. An alternative to combination antibiotic therapy for treating soft tissue pelvic infections in women.
Soft tissue pelvic infections--i.e., postpartum endometritis, endometritis, pelvic inflammatory disease and pelvic cellulitis--are predominantly polymicrobial. The microflora of these infections consists of a mixture of gram-positive and -negative bacteria, including aerobes and facultative and obligate anaerobes. Clindamycin plus gentamicin has been the principal antibiotic combination utilized for treatment of these infections. Ticarcillin/clavulanate appears to be an excellent replacement for initiating empiric therapy for these infections because of its safety and broad spectrum of activity, which includes gram-negative and -positive aerobic and anaerobic bacteria.
Faro
S
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Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
D001424:Bacterial Infections / Q000188:drug therapy*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D010406:Penicillins / Q000008:administration & dosage*; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*; D013982:Ticarcillin / Q000008:administration & dosage* / Q000627:therapeutic use
D002969:Clavulanic Acids; D010406:Penicillins; D019818:Clavulanic Acid; D013982:Ticarcillin