Comparison of active sites of some microbial ribonucleases: structural basis for guanylic specificity.
Crystallographic studies of enzymes complexed with suitable ligands are an important tool to aid our understanding of biological catalysis. To this goal, a contribution is made by analysing structures of complexes formed by three guanyl-specific ribonucleases with guanosine 3'-monophosphate.
Sevcik
J
J
Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava.
Sanishvili
R G
RG
Pavlovsky
A G
AG
Polyakov
K M
KM
D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology; D001665:Binding Sites; D005658:Fungi / Q000201:enzymology; D006150:Guanine Nucleotides / Q000378:metabolism*; D006157:Guanosine Monophosphate / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012260:Ribonucleases / Q000378:metabolism*; D012689:Sequence Homology, Nucleic Acid; D013379:Substrate Specificity
D006150:Guanine Nucleotides; D006157:Guanosine Monophosphate; D012260:Ribonucleases