title: The relationship of plasminogen activators and oncogenes to tumour invasion.
abstract: Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.
authors.affiliation: Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.
authors.forename: J S
authors.initials: JS
authors.lastname: Gelister
authors.forename: P B
authors.initials: PB
authors.lastname: Boulos
authors.forename: P J
authors.initials: PJ
authors.lastname: Gaffney
authors.forename: M
authors.initials: M
authors.lastname: Mahmoud
authors.forename: M R
authors.initials: MR
authors.lastname: Lewin
mesh_terms: D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis; D009857:Oncogenes; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism; D010960:Plasminogen Activators / Q000502:physiology*
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D010960:Plasminogen Activators