title: A clinicopathologic study of tumors and tumor-like lesions of the penis.
abstract: A total of 147 specimens from 93 patients with penile lesions were examined at Nagasaki University Hospital during a 27-year period from 1961 to 1987. The most frequent malignant tumor was squamous cell carcinoma (SCC, 33 cases, 35.5%), followed by extramammary Paget's disease, transitional cell carcinoma, and Bowen's disease. The benign tumors and tumor-like lesions included condyloma acuminatum, cyst of the genitoperineal raphe, and lymphangioma. SCC of the penis accounted for less than 0.1% of all specimens and less than 0.62% of malignant tumors in men filed at our hospital. True phimosis accompanied 81.5% of the SCC cases. The 5- and 10-year survival rates for SCC were 77.2% and 71.3%, respectively. Two patients died of penile SCC. It was considered that an absence of both keratohyaline granules in the granular layer and melanin pigment in the basal layer can serve as a useful histologic indicator for diagnosis of well differentiated SCCs that are otherwise difficult to identify.
authors.affiliation: Department of Laboratory Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
authors.forename: O
authors.initials: O
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Kishikawa
authors.forename: M
authors.initials: M
authors.lastname: Iseki
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003218:Condylomata Acuminata / Q000473:pathology; D003560:Cysts / Q000473:pathology; D006801:Humans; D008202:Lymphangioma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology; D010409:Penile Diseases / Q000473:pathology*; D010412:Penile Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology