Localization of protein kinase C-beta-like immunoreactivity in the rat dorsal root ganglion.
The localization of protein kinase C-beta-like immunoreactivity (PKC-beta-LI) was studied in the rat dorsal root ganglion (DRG) using an antibody specific for a peptide sequence common to the beta 1- and beta 2-subtypes. PKC-beta-LI was seen in 45% of neuronal cell bodies and in nerve fibers, which were mostly myelinated. The PKC-beta-LI-containing cell bodies had a diameter significantly larger than the unlabeled cell bodies. The results suggest that PKC-beta is a PKC subtype involved in cell surface signal transduction in the subpopulation of large DRG neurons.
Roivainen
R
R
Department of Public Health, University of Tampere, Finland.
Koistinaho
J
J
Hervonen
A
A
D000818:Animals; D005727:Ganglia, Spinal / Q000166:cytology / Q000201:enzymology*; D007150:Immunohistochemistry; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011493:Protein Kinase C