[GABA acts through GABA A receptors on neurons of the hypothalamic magnocellular dorsal nucleus in the guinea-pig: in vitro intracellular study].
In guinea-pig hypothalamic slices, GABA, applied through perfusion medium or by iontophoresis, evoked a hyperpolarization or a depolarization in enkephalinergic neurons of the magnocellular dorsal nucleus (MDN). This effect was accompanied by an inhibition of action potentials. It persisted in the presence of tetrodotoxin and involved GABAA receptors, coupled to a chloride conductance. Our results are discussed in relation to immunocytochemical data on the enkephalinergic neurons of MDN, gathered after an increase of intracerebral GABA concentration.
Carette
B
B
U 156 I.N.S.E.R.M., Lille.
Poulain
P
P
Doutrelant
O
O
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000166:cytology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011963:Receptors, GABA-A / Q000493:pharmacokinetics*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid
Le GABA agit par des récepteurs GABAA sur les neurones du noyau magnocellulaire dorsal hypothalamique du cobaye: étude intracellulaire in vitro.