The inhibitory effects of prostaglandin E1 and indomethacin on the growth and metastasis of transplanted Lewis lung carcinoma in C57BL mice.
The effects of prostaglandin E1(PGE1), prostaglandin synthesis inhibitor and indomethacin (IN) on the growth and metastasis of Lewis lung carcinoma (LLC) were studied and their mechanisms of action were investigated. Seventy-five C57BL mice of both sexes were utilized in the experiment. It was found that both PGE1 and IN could significantly retard the growth of transplanted LLC and reduce the number of pulmonary metastatic foci. PGE1 obviously decreased the acid phosphatase (ACP) activity of LLC cells while IN showed no such effect. Besides, PGE1 could markedly elevate the plasma cAMP level of LLC-bearing mice, but not normal controls. Meanwhile, it could decrease plasma cGMP concentration of both normal and tumor-bearing mice. IN, like PGE1, could increase plasma cAMP and decrease plasma cGMP levels of LLC-bearing animals. TEM observation revealed that tumor cells treated with PGE1 and IN presented a series of degenerative and destructive changes. In addition, PGE1 and IN exhibited a different effect on several cell-mediated immune responses of the tumored hosts, the former inhibitory and the latter stimulatory. The possible mechanisms of action of the two chemicals are discussed.
Tang
D G
DG
Department of Pathology, Hubei Medical College, Wuhan.
Tian
H S
HS
D000293:Adolescent; D000527:Alprostadil / Q000627:therapeutic use*; D000818:Animals; D002648:Child; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation
D000242:Cyclic AMP; D000527:Alprostadil; D006152:Cyclic GMP; D007213:Indomethacin