Prevalence of antibody against non-A, non-B hepatitis virus in Japanese patients with hepatocellular carcinoma.
Antibodies against a possible causative agent of non-A, non-B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme-linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)-negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg-positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg-negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody-positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti-HCV antibody and HBsAg-negative hepatocellular carcinoma in Japan.
Ohkoshi
S
S
Third Department of Internal Medicine School of Medicine, Niigata University.
Kojima
H
H
Tawaraya
H
H
Miyajima
T
T
Kamimura
T
T
Asakura
H
H
Satoh
A
A
Hirose
S
S
Hijikata
M
M
Kato
N
N
D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D005260:Female; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male
D006508:Hepatitis Antibodies