Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation.
An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus.
Burstein
H
H
Department of Molecular Genetics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Resnick-Roguel
N
N
Hamburger
J
J
Arad
G
G
Malkinson
M
M
Kotler
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D002415:Cats; D002417:Cattle; D002449:Cell Aggregation; D002470:Cell Survival; D002478:Cells, Cultured; D002645:Chickens; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004730:Endothelium, Vascular / Q000166:cytology*; D015686:Gene Products, env / Q000235:genetics; D015752:Genes, env; D006394:Hemangiosarcoma / Q000382:microbiology; D008969:Molecular Sequence Data; D010957:Plasmids; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D004279:DNA, Viral; D015686:Gene Products, env