[Experimental model of hepatitis A in rhesus monkeys (Macaca mulatta) infected with human hepatitis A virus].
The focus of this paper is characterization of Hepatitis A experimental model obtained for the first time in rhesus monkeys (M. mulatta) infected with fecal isolate from a patient with Hepatitis A (HAV-H1). Monkeys were susceptible to oral and intravenous routes of HAV inoculation. The disease could be reproduced regularly in 4 passages as a result of which HAV strain continuously pathogenic for M. mulatta has been established. All 17 infected monkeys developed Hepatitis A with characteristic (except jaundice) patterns: shedding of virus with the stool, elevations of serum alanine aminotransferase level, appearance of IgM anti-HAV, morphological changes developed in the liver. Our data have demonstrated that the course of experimental Hepatitis A infection in M. mulatta is similar (in many respects) to that observed in man.
Shevtsova
Z V
ZV
Krylova
R I
RI
Doroshenko
N V
NV
Lomovskaia
I B
IB
Belova
E G
EG
Zairov
G K
GK
Dzhelieva
Z N
ZN
Lapin
B A
BA
Stakhanova
V M
VM
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D005243:Feces / Q000382:microbiology; D005260:Female; D006506:Hepatitis A / Q000276:immunology / Q000382:microbiology; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007275:Injections, Intravenous; D008099:Liver / Q000473:pathology; D008253:Macaca mulatta; D008297:Male
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D000410:Alanine Transaminase
Eksperimental'naia model' gepatita A na makakakh rezusakh (Macaca mulatta), zarazhennykh virusom gepatita A cheloveka.