[The results of hypophyseal irradiation with a proton beam in acromegaly patients].
The investigation of 26 acromegalic patients long after irradiation of the pituitary body with a proton beam showed clinical and hormonal improvement in 38% of the patients, clinical improvement without complete growth hormone normalization in 46%, and the absence of any effect in 15%. The latter was mainly a result of partial irradiation of pituitary adenoma. Some patients after proton irradiation demonstrated signs of adenohypophyseal functional insufficiency, more marked in patients with a decreased level of Gy (over 5 ng/ml). A conclusion is that proton beam therapy is effective (provided all criteria for patients' eligibility are observed) and can be used as an independent method for the treatment of acromegalic patients.
Marova
E I
EI
Avakian
M R
MR
Kirpatovskaia
L E
LE
Saakian
O A
OA
Anisimov
S I
SI
Chepyga
R V
RV
D000172:Acromegaly / Q000097:blood / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D000236:Adenoma / Q000097:blood / Q000000981:diagnostic imaging / Q000532:radiotherapy; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000503:physiopathology; D010910:Pituitary Irradiation / Q000009:adverse effects / Q000379:methods*; D010911:Pituitary Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000532:radiotherapy; D011522:Protons; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D011522:Protons
Rezul'taty oblucheniia gipofiza protonnym puchkom u bol'nykh agromegalieĭ.