The abnormal in vitro response to aspirin of platelets from aspirin-sensitive asthmatics is inhibited after inhalation of nedocromil sodium but not of sodium cromoglycate.
1. Blood platelets from patients with aspirin-sensitive asthma (ASA) generated cytotoxic mediators in the presence of aspirin. This abnormal in vitro response to aspirin was abolished within 1 h after nedocromil sodium inhalation but not after sodium cromoglycate inhalation. 2. Platelets recovered this reactivity to aspirin by 12 hours after nedocromil sodium treatment of ASA-patients. 3. The in vitro reactivity to aspirin of ASA platelets isolated before inhalation was inhibited in the presence of serum isolated 15 and 60 min after nedocromil sodium inhalation.
Marquette
C H
CH
Centre d'Immunologie et de Biologie Parasitaire (Unité mixte INSERM 167, CNRS 624), Institut Pasteur, Lille, France.
Joseph
M
M
Tonnel
A B
AB
Vorng
H
H
Lassalle
P
P
Tsicopoulos
A
A
Capron
A
A
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001249:Asthma / Q000503:physiopathology*; D001792:Blood Platelets / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004205:Cromolyn Sodium / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D008297:Male; D008875:Middle Aged; D017835:Nedocromil; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D015363:Quinolones; D017835:Nedocromil; D004205:Cromolyn Sodium; D001241:Aspirin