Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome.
A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.
Ramsingh
A
A
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Hixson
A
A
Duceman
B
B
Slack
J
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002678:Chimera; D003001:Cloning, Molecular; D003384:Coxsackievirus Infections / Q000097:blood / Q000473:pathology*; D004279:DNA, Viral / Q000235:genetics; D029822:Enterovirus B, Human / Q000235:genetics / Q000472:pathogenicity*; D005814:Genes, Viral; D051379:Mice; D008815:Mice, Inbred Strains; D012367:RNA, Viral / Q000235:genetics; D013154:Spleen / Q000473:pathology*; D014774:Virulence / Q000235:genetics
D001786:Blood Glucose; D004279:DNA, Viral; D012367:RNA, Viral