[The role of glucocorticoids in the post-vibration changes in inhibition mediation in the brain structures].
Low-frequency vertical vibration for 2 hours together with three-fold increase of glucocorticoids is accompanied by the disruption of typical relationships of neuromediator processes (norepinephrine- and serotoninergic mediation) as well as the reduction of the intensity of choline trapping with glucocorticoid perception. Glucocorticoid-related conformation changes in plasma membranes and a drastic increase of the cAMP level provide plasticity of both nonspecific (hypothalamus, raphe bluish sites and nuclei) and specific (Deiters' nuclei) structures. The relationships of neuromediator processes in different CNS structures depend on the content of glucocorticoids. This should be taken into consideration when developing pathogenetically adequate methods for restoring the vestibular component of the motion sickness syndrome.
Dmitriev
A S
AS
Taĭts
M Iu
MIu
Dudina
T V
TV
Kandybo
T S
TS
Elkina
A I
AI
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D003864:Depression, Chemical; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014732:Vibration
D002395:Catecholamines; D011965:Receptors, Glucocorticoid; D012701:Serotonin; D000242:Cyclic AMP; D003345:Corticosterone; D006854:Hydrocortisone
Rol' gliukokortikoidov v postvibratsionnykh sdvigakh tormoznoĭ mediatsii v strukturakh golovnogo mozga.