Novel effect of azide on sodium channel of Xenopus oocytes.
Bath application of a few mM of sodium azide to a voltage clamped oocyte activated a voltage dependent Na+ current. Characteristics of the azide-induced current were the same as those of already described Na+ current induced by prolonged depolarization. The Na+ current induced either by azide or depolarization was suppressed by the application of Ca2+ channel blockers (Diltiazem and La3+). Azide is known to affect some metabolic processes (ATP and cGMP production etc.), but the present effect could not be attributed to metabolic actions.
Ando
H
H
Department of Physiology, Kobe University School of Medicine, Japan.
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D004553:Electric Conductivity; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D019810:Sodium Azide; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D014982:Xenopus laevis
D001386:Azides; D015222:Sodium Channels; D019810:Sodium Azide; D004110:Diltiazem