title: DXS26 (HU16) is located in Xq21.1.
abstract: We have localized a single-copy DNA probe, HU16 (locus DXS26), to Xq21.1. The probe was isolated from a human-mouse hybrid X;13 library and mapped with human-mouse hybrids containing different portions of the human X chromosome and DNA from male patients with different X-chromosomal deletions. The following order of loci is proposed: Xcen-(DXS72,DXS169)-(DXS232,DSX26)-DXS1 21-DXS233-DXS165-TCD-DXS95-DXYS1-Xqter. HU16 will be useful in the study of the putative genes that reside in Xq21 and whose defects lead to deafness and mental retardation.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: E M
authors.initials: EM
authors.lastname: Sankila
authors.forename: G A
authors.initials: GA
authors.lastname: Bruns
authors.forename: M
authors.initials: M
authors.lastname: Schwartz
authors.forename: E
authors.initials: E
authors.lastname: Nikoskelainen
authors.forename: E
authors.initials: E
authors.lastname: Niebuhr
authors.forename: S V
authors.initials: SV
authors.lastname: Hodgson
authors.forename: A F
authors.initials: AF
authors.lastname: Wright
authors.forename: A
authors.initials: A
authors.lastname: de la Chapelle
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D015794:Choroideremia / Q000235:genetics; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015342:DNA Probes / Q000235:genetics* / Q000302:isolation & purification; D004262:DNA Restriction Enzymes; D005260:Female; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic / Q000235:genetics; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes