Inferior vena cava thrombosis in a child with nephroblastoma and combined deficiency of antithrombin III and free protein S.
A 3 1/2-year-old girl developed thrombosis of the inferior caval and renal veins several weeks after complete resection of a nephroblastoma. Her mother had suffered from pulmonary embolism at the age of 18 years. Familial antithrombin III deficiency and persistently lowered free protein S levels in the proposita were found. It is assumed that the combination of these two regulatory defects of hemostasis contributed to the early occurrence of this severe thrombotic event.
Demarmels
F
F
Central Hematology Laboratory, Inselspital, University of Bern, Switzerland.
Lüthy
A R
AR
Hirt
A
A
Furlan
M
M
Lämmle
B
B
D020152:Antithrombin III Deficiency; D001780:Blood Coagulation Tests; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D017293:Protein S; D013927:Thrombosis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014682:Vena Cava, Inferior; D009396:Wilms Tumor / Q000150:complications*
D006023:Glycoproteins; D017293:Protein S