The relationship of plasminogen activators and oncogenes to tumour invasion.
Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.
Gelister
J S
JS
Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.
Boulos
P B
PB
Gaffney
P J
PJ
Mahmoud
M
M
Lewin
M R
MR
D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis; D009857:Oncogenes; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism; D010960:Plasminogen Activators / Q000502:physiology*
D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D010960:Plasminogen Activators