The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo.
Chlorpromazine, an antipsychotic drug, is found to inhibit Na+,K(+)-ATPase activity in rat brain microsomal membranes in vitro in concentration and time dependent manner but some inconsistency is observed when the effect was studied with respect to different temperatures. Various ligands and/or substrate affect the inhibition by chlorpromazine in different ways. The in vivo study with this drug shows that the activities of Na+,K(+)-ATPase, Ca2(+)-ATPase and acetylcholinesterase in the microsomal membranes of different organs are inhibit with increases in concentration or lengths of time of treatment and then levels off.
Mazumder
B
B
Department of Chemistry, Bose Institute, Calcutta, India.
Mukherjee
S
S
Sen
P C
PC
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D001921:Brain / Q000201:enzymology; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D002746:Chlorpromazine / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013154:Spleen / Q000201:enzymology; D013696:Temperature; D013737:Testis / Q000201:enzymology
D000110:Acetylcholinesterase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002746:Chlorpromazine