title: Bicarbonate-based powder and paste dentifrice effects on caries.
abstract: The effects of sodium bicarbonate-based powder and paste dentifrices on dental caries and Streptococcus sobrinus recoveries in rats were studied. Three S. sobrinus 6715-13WT infected groups of specific pathogen-free weanling rats, consuming a diet which contains 56% sucrose, were topically treated with either demineralized water, dentifrice paste, or dentifrice powder. Both the paste and powder contained 0.22% (w/w) NaF. All topical treatments were given for one min daily per rat, five days a week. Animals' teeth were swabbed for recovery of 6715-13WT and total recoverable flora. Recoveries of 6715-13WT were 75% lower from both powder-treated and paste-treated dentifrice than from water-treated rats' teeth (p less than 0.001). Total caries scores were 45% lower for the powder-treated and 43% lower for the paste-treated rats than the water-treated ones (p less than 0.01). The major portion of the caries inhibition was evident on smooth tooth surfaces, 68% for powder-treated and 65% for paste-treated by comparison with water-treated animals (p less than 0.01), although a lesser caries reduction was also evident in tooth fissures (sulci). Thus, both powder and paste formulations of a sodium bicarbonate-based dentifrice containing 0.22% NaF equally and potently inhibited caries in rats, challenged bacteriologically and dietarily to develop severe caries.
authors.forename: J M
authors.initials: JM
authors.lastname: Tanzer
authors.forename: T
authors.initials: T
authors.lastname: McMahon
authors.forename: L
authors.initials: L
authors.lastname: Grant
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D009055:Mouth / Q000382:microbiology; D011208:Powders / Q000627:therapeutic use; D051381:Rats; D012964:Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D013291:Streptococcus / Q000254:growth & development; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D001639:Bicarbonates; D003802:Dentifrices; D011208:Powders; D014100:Toothpastes; D017693:Sodium Bicarbonate; D012964:Sodium