Collateral drug sensitivity induced in CPT-11 (a novel derivative of camptothecin)-resistant cell lines.
Collateral drug sensitivity was induced in CPT-11-resistant cell lines (CPT-K and T). Ten of the 19 kinds of antineoplastic agents (especially, 5 of 6 kinds of DNA topoisomerase II inhibiting agents) were effective in inducing collateral drug sensitivity. Alteration of DNA topoisomerase I seemed to be unrelated to acquisition of multidrug resistance.
Oguro
M
M
Division of Hematology and Chemotherapy, Chiba Cancer Center Hospital, Japan.
Seki
Y
Y
Okada
K
K
Andoh
T
T
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000077146:Irinotecan; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects*; D059005:Topoisomerase II Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D059005:Topoisomerase II Inhibitors; D000077146:Irinotecan; D002166:Camptothecin