title: RNA levels of neuronal nicotinic acetylcholine receptor subunits are differentially regulated in axotomized facial motoneurons: an in situ hybridization study.
abstract: In situ hybridization histochemistry using complementary RNA probes revealed that alpha 3 and beta 2 neuronal nicotinic acetylcholine receptor subunit mRNAs were expressed in 12% and 40% of facial motoneurons of the rat, respectively. The alpha 3 subunit mRNA signals disappeared in response to axotomy, whereas the beta 2 subunit mRNA signal was remarkably enhanced, suggesting that mRNA levels of receptor subunits are differentially regulated in axotomized motoneurons.
authors.affiliation: Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037.
authors.forename: E
authors.initials: E
authors.lastname: Senba
authors.forename: D M
authors.initials: DM
authors.lastname: Simmons
authors.forename: E
authors.initials: E
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Wada
authors.forename: L W
authors.initials: LW
authors.lastname: Swanson
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D005154:Facial Nerve / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D011149:Pons / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011978:Receptors, Nicotinic