The effects of surfactant systems and moisturizing products on the residual activity of a chlorhexidine gluconate handwash using a pigskin substrate.
A series of handwashing experiments using a pigskin substrate and Serratia marcescens as the contaminant compared the residual activity of a chlorhexidine detergent handwash product alone and in combination with anionic and nonionic-based moisturizing products and surfactant systems. The anionic based moisturizing products and the anionic surfactant system almost completely destroyed the residual antibacterial activity of the chlorhexidine, while the nonionic-based products had minimal effect.
Benson
L
L
Calgon Vestal Laboratories, St. Louis, Missouri 63110.
LeBlanc
D
D
Bush
L
L
White
J
J
D000287:Administration, Topical; D000818:Animals; D000838:Anions; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D006235:Hand Disinfection; D006801:Humans; D008954:Models, Biological; D012706:Serratia marcescens / Q000187:drug effects; D012867:Skin / Q000187:drug effects / Q000382:microbiology*; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013552:Swine
D000838:Anions; D013501:Surface-Active Agents; D002710:Chlorhexidine