title: The major histocompatibility complex and human evolution.
abstract: Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10,000 individuals.
authors.affiliation: Max-Planck Institut Für Biologie, Abteilung Immungenetik, Tübingen, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Gutknecht
authors.forename: N
authors.initials: N
authors.lastname: Fischer
mesh_terms: D000483:Alleles; D005075:Biological Evolution; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D011110:Polymorphism, Genetic