Differences in luteinizing hormone release stimulated in rat anterior pituitary cells by leukotriene C4 and by gonadotropin-releasing hormone in vitro.
Continuous administration of leukotriene C4 (LTC4, 10(-10) M) to superfused rat anterior pituitary cells increased LH release for 40 min only, whereas in a parallel experiment gonadotropin-releasing hormone (GnRH, 10(-9) M) evoked a continuous increase in hormone secretion. In contrast to GnRH, LTC4 did not desensitize rat anterior pituitary cells. The secretory action resulting from the administration of LTC4 (10(-10) M) was abolished for 40 min after previous stimulation. The results documented the dual action of LTC4 on LH exocytosis.
Przylipiak
A
A
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology, Heidelberg, Federal Republic of Germany.
Kiesel
L
L
Przylipiak
M
M
Runnebaum
B
B
D000818:Animals; D002478:Cells, Cultured; D007986:Luteinizing Hormone / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D013189:SRS-A / Q000494:pharmacology*; D013268:Stimulation, Chemical
D010906:Pituitary Hormone-Releasing Hormones; D013189:SRS-A; D007986:Luteinizing Hormone