On the evolutionary origins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system.
The genes encoding the proteins of the fructose-specific phosphotransferase system (PTS) of Rhodobacter capsulatus were sequenced, and the deduced amino acyl sequences of the energy-coupling protein, Enzyme I, and the transport protein, Enzyme IIfru, were compared with published sequences. Enzyme I was found to be homologous to pyruvate:phosphate dikinase of plants, while Enzyme IIfru was found to be homologous to the insulin-responsive glucose facilitator of mammals. The evolutionary and functional implications of these findings are discussed.
Wu
L F
LF
Department of Biology, University of California, San Diego, La Jolla 92093.
Saier
M H
MH
D000595:Amino Acid Sequence; D005075:Biological Evolution; D005632:Fructose / Q000378:metabolism*; D005798:Genes, Bacterial; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000235:genetics; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000235:genetics* / Q000378:metabolism; D017852:Phosphotransferases (Nitrogenous Group Acceptor); D011772:Pyruvate, Orthophosphate Dikinase / Q000235:genetics; D016354:Rhodobacter capsulatus / Q000201:enzymology* / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D007328:Insulin; D009004:Monosaccharide Transport Proteins; D005632:Fructose; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D017852:Phosphotransferases (Nitrogenous Group Acceptor); C022360:phosphoenolpyruvate-protein phosphotransferase; D011772:Pyruvate, Orthophosphate Dikinase; D005947:Glucose