title: [Antifungal agents in dermatophytic disease: failure of griseofulvin, ketoconazole and itraconazole].
abstract: The dermatophytic disease is a rare, severe affection caused by banal dermatophytes. A genetically predisposed basis could explain the frequent failure of antifungal therapeutics. We report here the case of a 28-year-old male. Despite 2 years of griseofulvin, 23 months of ketoconazole and 8 months of itraconazole, the therapeutic failure was evident: circinate herpes, papulo-nodules, vegetating plaques, ulceration, superficial and profound adenopathies, cerebral involvement, and deterioration of the general state. The correction of the immuno-deficient state combined with antifungals could be the best therapy.
authors.affiliation: Service de Dermato-Vénéréologie, C. H. U. de Tlemcen, Algérie.
authors.forename: O
authors.initials: O
authors.lastname: Boudghène-Stambouli
authors.forename: A
authors.initials: A
authors.lastname: Mérad-Boudia
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000235:genetics; D004359:Drug Therapy, Combination; D006118:Griseofulvin / Q000008:administration & dosage; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D014005:Tinea / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D006118:Griseofulvin; D007654:Ketoconazole
vernacular_title: Les antifungiques dans la maladie dermatophytique: échec de la griséofulvine, du kétoconazole et de l'itraconazole.