Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
The density of cortical [3H]nitrendipine binding sites was elevated by over 40% in rats rendered morphine-abstinent by administration of naloxone after chronic treatment with morphine. The morphine-abstinent rats had significantly shortened response latencies in the hot-plate test. Nifedipine treatment abolished the signs of abstinence and normalized the hot-plate latencies in morphine-dependent, naloxone-treated rats. The results indicate that the symptoms of abstinence are related to a functional state of cortical dihydropyridine-sensitive calcium channels.
Antkiewicz-Michaluk
L
L
Department of Biochemistry, Polish Academy of Sciences, Krakow.
Michaluk
J
J
Romańska
I
I
Vetulani
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004095:Dihydropyridines / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009021:Morphine Dependence / Q000523:psychology*; D009270:Naloxone; D009543:Nifedipine / Q000494:pharmacology; D009568:Nitrendipine / Q000378:metabolism; D010147:Pain Measurement; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D004095:Dihydropyridines; D011978:Receptors, Nicotinic; D009270:Naloxone; D009568:Nitrendipine; D009543:Nifedipine