Phosphorylation of an inositol phosphate-stimulated protein phosphatase by protein kinase C.
It is shown that the catalytic subunit of an inositol phosphate-stimulated protein phosphatase (a member of the type-1 protein phosphatase family) purified from bovine brain membranes is phosphorylated in vitro by protein kinase C, but not by protein kinase A or by Ca2+/calmodulin-dependent protein kinase II. The phosphorylation of the protein phosphatase by protein kinase C induces an increased sensitivity to stimulation by Ins (1,4,5)P3, Ins(1,3,4,5,6)P5 and heparin.
Zwiller
J
J
Centre de Neurochimie CNRS, Strasbourg, France.
Revel
M O
MO
Boynton
A L
AL
Honkanen
R
R
Vincendon
G
G
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002417:Cattle; D002462:Cell Membrane / Q000201:enzymology; D006493:Heparin / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology; D007295:Inositol Phosphates / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology; D010718:Phosphatidylserines / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007295:Inositol Phosphates; D010718:Phosphatidylserines; C013571:inositol pentaphosphate; D015544:Inositol 1,4,5-Trisphosphate; D006493:Heparin; D011494:Protein Kinases; D011493:Protein Kinase C; D010749:Phosphoprotein Phosphatases; D013755:Tetradecanoylphorbol Acetate