Cultured glial precursor cells from mouse cortex express two types of calcium currents.
Glial precursor cells of the oligodendrocyte lineage express two types of Ca2+ channels which can be distinguished by their peak activation. Ca2+ currents were recorded using the patch-clamp technique in the whole cell configuration and were found to be similar to the low and the high voltage activated Ca2+ channel described in neurons. While the majority of precursor cells expressed only one of the two current types respectively, in 30% of cells both types of current could be identified. These Ca2+ channels might play an important role in signal transduction during target recognition of the developing glial cell.
Verkhratsky
A N
AN
Department of Neurobiology, University of Heidelberg, F.R.G.
Trotter
J
J
Kettenmann
H
H
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology*; D002478:Cells, Cultured; D004558:Electric Stimulation; D008564:Membrane Potentials; D051379:Mice; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium