Selective syncytium formation by murine leukemia virus in rat 3Y1 fibroblasts transformed by adenovirus type 12 or its E1A gene.
3Y1 rat fibroblasts transformed by adenovirus type 12 or by its E1A gene formed syncytia when cocultivated with the Friend as well as other ecotropic murine leukemia-virus-producing cells. In contrast, the parental 3Y1 cells and those transformed by other tumor viruses or by a chemical carcinogen exhibited no syncytium formation.
Momozaki
N
N
Department of Biochemistry, Saga Medical School, Japan.
Ogura
H
H
Matsuhashi
S
S
Joh
K
K
Tabuchi
K
K
Kimura
G
G
Hori
K
K
D017456:Adenovirus Early Proteins; D000260:Adenoviruses, Human / Q000235:genetics / Q000502:physiology; D000818:Animals; D002459:Cell Fusion; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D005347:Fibroblasts; D005622:Friend murine leukemia virus / Q000502:physiology; D015726:Giant Cells / Q000502:physiology*; D009052:Leukemia Virus, Murine / Q000502:physiology*; D009856:Oncogene Proteins, Viral / Q000235:genetics; D051381:Rats
D017456:Adenovirus Early Proteins; D009856:Oncogene Proteins, Viral