Endocrine, metabolic and cardiovascular responses to adrenaline after abdominal surgery.
Adrenaline-induced changes in heart rate, blood pressure, plasma adrenaline and noradrenaline, cortisol, glucagon, insulin, cAMP, glucose lactate, glycerol and beta-hydroxybutyrate were studied preoperatively and 4 and 24 h after skin incision in 8 patients undergoing elective cholecystectomy. Late postoperative responses of blood glucose, plasma cAMP, lactate and glycerol to adrenaline infusion were reduced, whereas other responses were unaffected. Blood glucose appearance and disappearance rate as assessed by [3H]3-glucose infusion was unchanged pre- and postoperatively. The increase in glucose appearance rate following adrenaline was similar pre- and postoperatively. These findings suggest that several beta-receptor-mediated responses to adrenaline are reduced after abdominal surgery.
Hilsted
J
J
Surgical Department, Glostrup Hospital, Copenhagen, Denmark.
Wilken-Jensen
C
C
Birch
K
K
Damkjaer Nielsen
M
M
Holst
J J
JJ
Kehlet
H
H
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood*; D002763:Cholecystectomy; D000242:Cyclic AMP / Q000097:blood; D062109:Dermatologic Surgical Procedures; D004837:Epinephrine / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000097:blood; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood*; D007773:Lactates / Q000097:blood; D011184:Postoperative Period
D001786:Blood Glucose; D002395:Catecholamines; D006885:Hydroxybutyrates; D007328:Insulin; D007773:Lactates; D005934:Glucagon; D000242:Cyclic AMP; D005990:Glycerol; D006854:Hydrocortisone; D004837:Epinephrine