title: The outcome of triplet, quadruplet, and quintuplet pregnancies managed in a perinatal unit: obstetric, neonatal, and follow-up data.
abstract: Multifetal gestation is associated with increased frequency of maternal complications and higher perinatal morbidity and mortality. The need for contemporary data on the outcome of multifetal gestations is further underscored when selective reduction is considered. The present study details the obstetric management, neonatal outcome, and follow-up data of 24 triplet, five quadruplet, and one quintuplet pregnancies delivered in a perinatal center. The early neonatal mortality rate was 31.6, the late neonatal mortality rate was 21, and the perinatal mortality rate was 51.5. Survival to discharge was 93%. The incidence of respiratory distress syndrome was 43%, bronchopulmonary dysplasia 6%, retinopathy of prematurity 3%, intraventricular hemorrhage 4%, and cerebral palsy 2%. Follow-up from 1 to 10 years shows that only one child is moderately handicapped, whereas 99% have no significant medical problem. Early diagnosis by ultrasonography, meticulous antenatal care, early hospitalization, delivery by cesarean section, and on-site availability of a neonatologist for each baby at the time of delivery are the probable major determinants of improved outcome.
authors.affiliation: Regional Perinatal Unit, Women's College Hospital, Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Gonen
authors.forename: E
authors.initials: E
authors.lastname: Heyman
authors.forename: E V
authors.initials: EV
authors.lastname: Asztalos
authors.forename: A
authors.initials: A
authors.lastname: Ohlsson
authors.forename: L C
authors.initials: LC
authors.lastname: Pitson
authors.forename: A T
authors.initials: AT
authors.lastname: Shennan
authors.forename: J E
authors.initials: JE
authors.lastname: Milligan
mesh_terms: D002657:Child Development; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011783:Quadruplets; D011811:Quintuplets; D014310:Triplets; D014463:Ultrasonography