title: [Chemotherapy of advanced non-small cell bronchial cancer with mitomycin C/ifosfamide versus mitomycin C/vindesine versus cisplatin/etoposide--a prospective randomized study].
abstract: In a prospective randomised study involving patients with inoperable non-small-cell lung cancer, no differences were to be seen in the remission rates (30.3%, 22.7% and 25%, respectively; p = 0.4) achieved by the combinations mitomycin/ifosfamide, mitomycin/vindesine and cisplatin/etoposide. Nor were any statistically significant differences to be found in terms of the duration of survival. The median survival durations were 6.5, 5.5 and 6 months, respectively (p = 0.7). With respect to toxicity, the combination mitomycin/vindesine proved to be superior, in particular since virtually no gastrointestinal toxicity was observed with this combination. On the basis of these results and the-state of our knowledge to date, the conclusion may be drawn that cisplatin-containing combinations should no longer be employed in the chemotherapeutic treatment of non-small-cell cancers.
authors.affiliation: Pneumologisch-Onkologische Abteilung, Krankenhaus Grosshansdorf.
authors.forename: U
authors.initials: U
authors.lastname: Gatzemeier
authors.forename: M
authors.initials: M
authors.lastname: Heckmayr
authors.forename: D K
authors.initials: DK
authors.lastname: Hossfeld
authors.forename: E
authors.initials: E
authors.lastname: Kaukel
authors.forename: G
authors.initials: G
authors.lastname: Koschel
authors.forename: R
authors.initials: R
authors.lastname: Neuhauss
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D005047:Etoposide; D002945:Cisplatin; D014751:Vindesine; D007069:Ifosfamide
vernacular_title: Chemotherapie des fortgeschrittenen nicht-kleinzelligen Bronchialkarzinoms mit Mitomycin-C/Ifosfamid versus Mitomycin-C/Vindesin versus Cisplatin/Etoposid--Eine prospektiv randomisierte Studie.