title: Preliminary studies on the phenomenological behaviour of osteoblasts cultured on hydroxyapatite ceramics.
abstract: SEM was used to investigate the phenomenological behaviour of osteoblasts towards sintered hydroxyapatite. The osteoblasts were seeded on to porous and dense hydroxyapatite and cultured for 4 to 28 d. They attached and adhered on to the hydroxyapatite surfaces, proliferated and secreted extracellular matrix. No signs of toxicity embarrassment were apparent. It is argued that cell phenomenology seems to be a prerequisite to morphogenesis, and on this premise it is speculated that surface-reactive bone replacement materials owe their compatibility to the ability of their surfaces to interact favourably with the peptides involved in osteomorphogenesis and bone repair.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Freiburg University, FRG.
authors.forename: F B
authors.initials: FB
authors.lastname: Bagambisa
authors.forename: U
authors.initials: U
authors.lastname: Joos
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D002516:Ceramics; D017886:Durapatite; D006882:Hydroxyapatites; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000502:physiology* / Q000648:ultrastructure; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite