Respiratory response and pharmacokinetics of intravenous salbutamol in infants with bronchopulmonary dysplasia.
The effects of iv salbutamol on respiratory mechanics were studied in six infants with bronchopulmonary dysplasia. Salbutamol was infused at a dose of 30 micrograms/kg over 30 min in five infants; a sixth infant received 66.7 micrograms/kg over 4 min. Salbutamol caused improvement in total respiratory system compliance and in airflow resistance. There was no correlation between salbutamol serum concentration and pulmonary function. Elimination half-time appears to be dictated in these infants more by the distribution volume (Vd) than by clearance (Cl). The area under concentration-time curve of salbutamol correlated inversely to the change in heart rate (HR). There was a significant positive correlation between Vd and percent HR change. These data provide evidence that preterm infants have measurable activity of bronchiolar beta 2 receptor responsive to salbutamol.
Kirpalani
H
H
Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada.
Koren
G
G
Schmidt
B
B
Tan
Y
Y
Santos
R
R
Soldin
S
S
D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008170:Lung Compliance / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D012119:Respiration / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D000420:Albuterol