Alterations in rat brain [3H]-TCP binding following chronic phencyclidine administration.
Rats were chronically infused with phencyclidine (PCP, 13.3 mg PCP.HCl/kg/day) or saline, s.c., for 10 days using osmotic minipumps (n = 5 for each group). Twenty-four hours after the cessation of dosing, the rats were sacrificed, and brains were removed for analysis of PCP receptor binding. Saturation studies of the binding of [3H]-TCP to brain homogenates revealed statistically significant increases in the maximum binding capacity (Bmax) and decreases in the affinity for [3H]-TCP in the PCP-treated group.
Massey
B W
BW
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
Wessinger
W D
WD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006207:Half-Life; D015918:Infusion Pumps, Implantable; D008297:Male; D010622:Phencyclidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D017478:Receptors, Phencyclidine
D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; C012058:tenocyclidine; D010622:Phencyclidine