title: Acute toxicity from BOPP (BCNU, vincristine, procarbazine, cisplatinum) chemotherapy for glioblastoma multiforme.
abstract: Between January 1988 and October 1988, we treated 12 patients with glioblastoma multiforme with BOPP chemotherapy after surgery and radiotherapy. The protocol consisted of BCNU 50 mg/m2 days 1-3, vincristine 1.4 mg/m2 (maximum 2 mg) day 1, procarbazine 50 mg/m2, days 1-7 and cisplatinum 20 mg/m2, days 1-3. All patients had at least three courses of chemotherapy ECOG toxicity criteria were used. We observed 9/12 changes in WBC, 7/12 in Hgb. All patients had nausea and vomiting. We also observed 2/12 neuropathies related to CNS. Other toxicities were not observed.
authors.affiliation: K.B.C. Kragujevac, Department of Oncology and Nuclear Medicine, Yugoslavia.
authors.forename: B
authors.initials: B
authors.lastname: Jeremić
authors.forename: Z
authors.initials: Z
authors.lastname: Barjaktarević
authors.forename: L
authors.initials: L
authors.lastname: Mijatović
authors.forename: L
authors.initials: L
authors.lastname: Djurić
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D011344:Procarbazine; D014750:Vincristine; D002945:Cisplatin; D002330:Carmustine