title: Acute megakaryoblastic leukemia: a case report.
abstract: We present a case of acute megakaryoblastic leukemia identified by electron microscopy and platelet-specific antibodies. The histological examination of bone marrow showed distinct myelofibrosis. In accordance with recent communications, low-dose cytosine arabinoside treatment (20 mg twice daily s.c. over 21 days) was initiated. The subsequent bone marrow examination showed a severe hypoplasia with persistent blasts. Amsacrine and VP-16 were given without success. Finally the patient died of septicemia without proof of pathogen uninfluenced by antibiotic and antiseptic therapy 6 weeks after diagnosis. Our case report confirms the poor prognosis of acute megakaryoblastic leukemia.
authors.affiliation: Dept. Hematology/Oncology, St. Johannes-Hospital, Duisburg, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Donhuijsen-Ant
authors.forename: C
authors.initials: C
authors.lastname: Schadeck-Gressel
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Löffler
authors.forename: M
authors.initials: M
authors.lastname: Westerhausen
authors.forename: L D
authors.initials: LD
authors.lastname: Leder
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000368:Aged; D000677:Amsacrine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000201:enzymology / Q000648:ultrastructure; D055728:Primary Myelofibrosis / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; D000677:Amsacrine; D003561:Cytarabine; D005047:Etoposide; D000135:Acid Phosphatase