[A comparative study of the effects of lisinopril and quinapril administered once a day in essential hypertension].
The aim of the study was to compare efficacy and safety of quinapril and lisinopril once-daily administered in patients with mild to moderate hypertension. After a two-week placebo period, 23 patients with sitting diastolic blood pressure between 95 and 110 mmHg were randomly assigned to the therapy with quinapril 20 mg/die or lisinopril 10 mg/die for 4 weeks in a single-blind design. After 4 weeks patients with diastolic blood pressure greater than 90 mmHg were treated with a higher dose (lisinopril 20 mg/die; quinapril 40 mg/die). Therapy with lisinopril normalized 83% of patients, and quinapril 45% of patients. Lisinopril was significantly better than quinapril in reducing blood pressure after 4 and 8 weeks of active treatment. The 24 hours ambulatory blood pressure monitoring showed that quinapril failed to control blood pressure after 12 hours from the administration of the drug.
De Cesaris
R
R
Cattedra di Terapia Medica, Istituto di Patologia Medica, Università degli Studi di Bari.
Ranieri
G
G
Andriani
A
A
Chiarappa
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D015924:Blood Pressure Monitors; D004361:Drug Tolerance; D004656:Enalapril / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000008:administration & dosage*; D017706:Lisinopril; D008875:Middle Aged; D000077583:Quinapril; D016032:Randomized Controlled Trials as Topic; D016037:Single-Blind Method; D044005:Tetrahydroisoquinolines; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D004656:Enalapril; D017706:Lisinopril; D000077583:Quinapril
Studio comparativo degli effetti del lisinopril e del quinapril in monosomministrazione giornaliera nell'ipertensione essenziale.