title: A new circulating hypertensive factor in the plasma of essential hypertensive subjects.
abstract: The pressor responses to dialyzed plasma extracts from normotensive (n = 15) and essential hypertensive (n = 14) human subjects were evaluated in anesthetized Sprague-Dawley rats. Hypertensive but not normotensive plasma raised mean arterial pressure (23.6 +/- 3.6 versus -0.5 +/- 2.5 mmHg, P less than 0.0001), and this effect was correlated significantly with its ability to stimulate 45Ca uptake in rat tail artery vascular smooth muscle (r = 0.883, P less than 0.002). These data suggest a humoral contribution to the pathophysiology of essential hypertension in at least some individuals. The time-course and molecular weight distribution of the dialyzed plasma suggest that this effect is not due to known vasopressor substances, but to a factor we tentatively term plasma hypertensive factor.
authors.affiliation: Department of Physiology, University of Alberta, Edmonton, Canada.
authors.forename: R Z
authors.initials: RZ
authors.lastname: Lewanczuk
authors.forename: L M
authors.initials: LM
authors.lastname: Resnick
authors.forename: J D
authors.initials: JD
authors.lastname: Blumenfeld
authors.forename: J H
authors.initials: JH
authors.lastname: Laragh
authors.forename: P K
authors.initials: PK
authors.lastname: Pang
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014556:Urine / Q000032:analysis
chemical_list: D002118:Calcium