[Changes in the autonomic balance of the regulation of the rate of heart contractions during physical loading in chronic suppression or potentiation of the endogenous opioidergic system in rats].
The influence of endogenous opioid system on the rat's mean blood pressure (BP) and heart rate (HS) has been studied under the chronic infusion of the opioid receptor antagonist naloxone (1 mg/kg intraperitoneally, twice a day, during 6 days) or an inhibitor of captorile enkephalinases (20 mg/kg subcutaneously). Naloxone caused a significant decrease and captorile--increase of maximum meanings of HR during exercises (the running on the treadmill during 3.5 min by the velocity of 30 m/min), both compounds didn't exert a considerable effect on BP at rest and during exercises. It has been concluded that the endogenous opioid system plays an important role in the autonomic HR regulation during exercise.
Kuligina
L D
LD
Sokolova
N A
NA
Ashmarin
I P
IP
Shvarts
G Ia
GIa
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D011674:Pulse / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D011957:Receptors, Opioid; D009270:Naloxone; D002216:Captopril
Izmenenie vegetativnogo balansa reguliatsii chastoty serdechnykh sokrashcheniĭ v usloviiakh fizicheskoĭ nagruzki pri khronicheskom podavlenii ili potentsiatsii éndogennoĭ opioidergicheskoĭ sistemy u krys.