title: Effect of cardiac tamponade on atrial natriuretic peptide concentrations: influence of stretch and pressure.
abstract: 1. In order to study the role of atrial pressure and atrial stretch on the release of atrial natriuretic peptide we have measured plasma atrial natriuretic peptide concentration, urine output and haemodynamic variables in eight patients during and 30 min after the relief of cardiac tamponade. This condition is characterized by high atrial pressure with little or no atrial stretch. 2. Relief of tamponade was associated with a rise in urine output (53 +/- 27.9 to 101 +/- 24.5 ml/h, mean +/- SEM; P = 0.09), systolic blood pressure (95 +/- 9.6 to 126 +/- 7.0 mmHg, P less than 0.0001), and plasma atrial natriuretic peptide concentration (369.5 +/- 70.9 to 490.3 +/- 94.7 pg/ml, P less than 0.05) despite a large fall in right atrial pressure (18.6 +/- 1.6 to 9.5 +/- 1.3 mmHg, P less than 0.001). 3. These results suggest, therefore, that an increase in atrial stretch, rather than in atrial pressure, stimulates the release of atrial natriuretic peptide.
authors.affiliation: Department of Cardiac Surgery, Royal Infirmary of Edinburgh, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Au
authors.forename: J E
authors.initials: JE
authors.lastname: Brown
authors.forename: M R
authors.initials: MR
authors.lastname: Lee
authors.forename: N A
authors.initials: NA
authors.lastname: Boon
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D002305:Cardiac Tamponade / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D014554:Urination
chemical_list: D009320:Atrial Natriuretic Factor