Proto-oncogenes in cell differentiation.
Proto-oncogene products may be multi-functional proteins with various roles in cell differentiation as well as cell proliferation. The molecular biology of the gene products of three well characterized proto-oncogenes (c-fos, c-myc and c-src) are described, and the roles of three other proto-oncogene products, involved in hormone and growth factor reception, are reviewed.
Zelenka
P S
PS
Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D011956:Receptors, Cell Surface / Q000502:physiology
D006133:Growth Substances; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases