The effects of various anesthetics on tissue levels of fructose-2,6-bisphosphate in rats.
We report that the short-term use of various anesthetic agents prior to decapitation causes alteration of the levels of fructose-2,6-bisphosphate in kidney, brain, heart, muscle, and liver. These data indicate that even light anesthesia can not be used when levels of this metabolite are to be determined. Also, it appears that the use of any of these anesthetics can profoundly alter glucose utilization in many tissues.
Kasten
T
T
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-9230.
Colliver
J A
JA
Montrey
R D
RD
Dunaway
G A
GA
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry; D002697:Chloral Hydrate / Q000494:pharmacology; D002698:Chloralose / Q000494:pharmacology; D005065:Euthanasia / Q000662:veterinary; D005635:Fructosediphosphates / Q000032:analysis*; D006221:Halothane / Q000494:pharmacology; D006598:Hexosediphosphates / Q000032:analysis*; D007649:Ketamine / Q000494:pharmacology; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000777:Anesthetics; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D002698:Chloralose; D002697:Chloral Hydrate; D007649:Ketamine; C027652:fructose 2,6-diphosphate; D010424:Pentobarbital; D006221:Halothane