Morphology and functional responses of isolated zona glomerulosa cells of streptozotocin-induced diabetic rats.
Streptozotocin-induced diabetes significantly decreased plasma aldosterone concentration in rats whose renin-angiotensin system had been pharmacologically interrupted. Isolated zona glomerulosa cells showed a marked atrophy, coupled with a reduced basal secretion of aldosterone and corticosterone. The secretory response to the three main physiological stimuli (ACTH, angiotensin II and potassium) was also notably impaired. The hypothesis is advanced that the chronic lack of insulin may directly impair the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
Andreis
P G
PG
Department of Anatomy, University of Padua, Italy.
Mazzocchi
G
G
Cavallini
L
L
Rebuffat
P
P
Nussdorfer
G G
GG
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D006943:Hyperglycemia / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D015384:Zona Glomerulosa / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure
D000804:Angiotensin II; D000450:Aldosterone; D013311:Streptozocin; D000324:Adrenocorticotropic Hormone; D011188:Potassium; D003345:Corticosterone