Slipping pumps or proton leaks in oxidative phosphorylation. The local anesthetic bupivacaine causes slip in cytochrome c oxidase of mitochondria.
van Dam
K
K
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Shinohara
Y
Y
Unami
A
A
Yoshida
K
K
Terada
H
H
D000817:Anilino Naphthalenesulfonates / Q000494:pharmacology; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D006180:Proton-Translocating ATPases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000817:Anilino Naphthalenesulfonates; C027132:1-anilino-8-naphthalenesulfonate; D003576:Electron Transport Complex IV; D006180:Proton-Translocating ATPases; D002045:Bupivacaine