title: The high affinity receptor for omega-conotoxin represents calcium channels different from those sensitive to dihydropyridines in mammalian brain.
abstract: A monoclonal antibody recognizing the alpha 2 delta complex of the dihydropyridine (DHP)-sensitive calcium channel of skeletal muscle immunoprecipitated most of the DHP receptor solubilized from bovine and rabbit brains, and bovine cardiac muscle. However, it did not significantly immunoprecipitate the high affinity omega-conotoxin receptor solubilized from these brains. These results indicate that the DHP receptor and the high affinity omega-conotoxin receptor are different molecules in mammalian brain.
authors.affiliation: Department of Neurochemistry, Faculty of Science, Niigata University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Mitsui
authors.forename: K J
authors.initials: KJ
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Saisu
authors.forename: T
authors.initials: T
authors.lastname: Abe
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001665:Binding Sites; D001923:Brain Chemistry; D015220:Calcium Channels / Q000737:chemistry* / Q000276:immunology; D002417:Cattle; D020916:Conotoxins; D051379:Mice; D008807:Mice, Inbred BALB C; D008861:Microsomes / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D010456:Peptides, Cyclic / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D011978:Receptors, Nicotinic / Q000032:analysis* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015220:Calcium Channels; D020916:Conotoxins; D010456:Peptides, Cyclic; D011978:Receptors, Nicotinic; C055407:conotoxin GV