[The effect of indomethacin on the activity of Na+,K+- and HCO3--ATPases and prostaglandin levels in the rat ileum mucosa after exposure to cholera exotoxin].
Preadministration of indomethacin (10 mg/kg of rat body mass), 1 hr before choleraic toxin injection, removed the toxin inhibitory effect on activity of Na+, K(+)-ATPase and decreased distinctly its inhibitory action on HCO3(-)-ATPase. At the same time, the indomethacin premedication caused a decrease in content of prostaglandins PGE, 6-keto-PGF1 alpha and of thromboxane B2 as compared with the choleraic toxin effect and controls. The data obtained corroborate the hypothesis on antisecretory effect of indomethacin occurring via PG-dependent mechanism.
Dolmatova
L S
LS
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D027321:Anion Transport Proteins; D002772:Cholera Toxin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005098:Exotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007082:Ileum / Q000201:enzymology* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
D027321:Anion Transport Proteins; D005098:Exotoxins; D011453:Prostaglandins; D002772:Cholera Toxin; D000251:Adenosine Triphosphatases; C031652:anion-sensitive ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D007213:Indomethacin
Vliianie indometatsina na aktivnost' Na+,K+- i HCO3--ATFaz i soderzhanie prostaglandinov v slizistoĭ obolochke podvsdoshnoĭ kishki krys pri vozdeĭstvii kholernogo ékzotoksina.