Expression of insulin-like growth factor 1 in sarcomas.
The expression of insulin-like growth factor-1 (IGF-1) was studied in normal tissues, in eight benign lesions and in 50 sarcomas. In palmar fibromatosis the spindle cells in cell-dense areas exhibited a strong immunoreactivity. IGF-1 was variably found in leiomyosarcomas (7/8), malignant schwannomas (7/9), synovial sarcomas (2/3), liposarcomas (3/6), fibrosarcomas (1/3), malignant fibrous histiocytomas (10/18) and in one angiosarcoma. Two rhabdomyosarcomas failed to express IGF-1 and only the spindle cell component of synovial sarcomas was positive. Immunoreactivity for IGF-1 in 10 malignant filrous histiocytomas (MFH) appeared to be related to co-expression of smooth muscle actin. These findings imply that MFHs can be subdivided into a group of tumours which are devoid of morphological and immunophenotypic evidence of differentiation and a group which manifest immunophenotypic differentiation.
Roholl
P J
PJ
Institute for Experimental Gerontology, Department for Electron Microscopy, Rijswijk, The Netherlands.
Skottner
A
A
Prinsen
I
I
Lips
C J
CJ
Den Otter
W
W
Van Unnik
J A
JA
D000199:Actins / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D003893:Desmin / Q000378:metabolism; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D012509:Sarcoma / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D013002:Somatomedins / Q000378:metabolism*
D000199:Actins; D014408:Biomarkers, Tumor; D003893:Desmin; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I