[Experimental research on the effect of ultraviolet irradiation on the phosphorus-calcium metabolic status].
The influence of vitamin D and ultraviolet irradiation (UVI), used for prevention of vitamin D deficiency, on the state of phosphoric-calcium metabolism was studied in experiments on rats. It has been shown that daily injections of 1-5 IU of vitamin D, and UVI in biodoses from 1/8 to 1/4 promote the maintainance of the normal level of phosphoric-calcium metabolism. When UVI was applied according to the widely used "basic scheme" (in biodoses from 1/4 to 2 1/2) the following anomalies were recorded: a three-fold increase of 25-ON-D3 concentration in the blood plasma, hyperphosphatemia, a tendency to hypercalcemia. The use of higher doses of UVI led to a further increase of 25-OH-D3 level, hypophosphatemia, hypercalcemia, kidney and heart calcification. The data obtained have evidenced a possibility of vitamin D intoxication during UVI.
Antonova
N P
NP
Lazareva
N P
NP
Kalita
N F
NF
Petrova
E A
EA
D000818:Animals; D002118:Calcium / Q000097:blood / Q000528:radiation effects*; D002762:Cholecalciferol / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008297:Male; D010758:Phosphorus / Q000097:blood / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014466:Ultraviolet Rays; D014808:Vitamin D Deficiency / Q000097:blood / Q000517:prevention & control
D002762:Cholecalciferol; D010758:Phosphorus; D002118:Calcium
Eksperimental'noe issledovanie vliianiia ul'trafioletovogo oblucheniia na sostoianie fosforno-kal'tsievogo obmena.