title: Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus.
abstract: The analysis of the antigenic and transforming properties of the DB strain of the human polyomavirus BK Virus [BKV(DB)] is presented. Two genomes were molecularly cloned from a single virus preparation and were shown to represent viable virus; one clone [pBKV(DB)dl82] contained an 82 nucleotide deletion in the regulatory region relative to the second clone [pBKV(DB)]; pBKV(DB)dl82 demonstrated enhanced lytic and transforming activities relative to pBKV(DB). BKV(DB) is antigenically distinct from the prototype Gardner strain of BK Virus, and 50 to 60% of the population display serological evidence of BKV(DB) infection. Implications of the existence of antigenic variants on estimation of BK virus prevalence in the population are discussed.
authors.affiliation: Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.
authors.forename: J E
authors.initials: JE
authors.lastname: Tavis
authors.forename: R J
authors.initials: RJ
authors.lastname: Frisque
authors.forename: D L
authors.initials: DL
authors.lastname: Walker
authors.forename: F A
authors.initials: FA
authors.lastname: White
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000940:Antigenic Variation / Q000235:genetics; D001483:Base Sequence; D002478:Cells, Cultured; D006387:Hemagglutination, Viral; D006801:Humans; D008969:Molecular Sequence Data; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology; D012333:RNA, Messenger / Q000737:chemistry; D051381:Rats; D014170:Transformation, Genetic
chemical_list: D000914:Antibodies, Viral; D012333:RNA, Messenger