Clinical pharmacology of antiepileptic drugs. Selected topics.
This article illustrates basic principles of clinical pharmacology presented in article 1 with specific examples from the treatment of seizure disorders. The discussion includes protein binding, the role of a major carbamazepine metabolite, alterations in pharmacology of AEDs in the elderly, and AED withdrawal. The last topic, in particular, is a good example of the interaction of pharmacokinetic and pharmacodynamic considerations in explaining the clinical effects of a drug.
Theodore
W H
WH
Clinical Epilepsy Section, National Institute of Neurological Disorder, and Stroke, National Institutes of Health, Bethesda, Maryland.
D000367:Age Factors; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged
D000927:Anticonvulsants