Amyloid-related neuropathies.
Formation of amyloid within peripheral nerves, resulting in amyloid-related neuropathies, may occur when myeloma-associated amyloid (AL) is deposited in an immune-related neuropathy or in familial amyloid polyneuropathy where prealbumin/transthyretin variants are marked by AF amyloid deposition. Refined histochemical and recent immunohistochemical techniques identify the correct type of amyloid and thus the nosologically precise form of amyloid-related neuropathy. Neuropathy is an inherent thought not obligate clinical and morphological component in two of the three systemic amyloidoses. Multiple causative factors in adult forms of neuropathy render a search for amyloid mandatory whenever respective biopsied nerve specimens are examined.
Goebel
H H
HH
Division of Neuropathology, University of Mainz, FRG.
Bohl
J
J
Störkel
S
S
D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000473:pathology*; D006801:Humans; D010525:Peripheral Nerves / Q000737:chemistry*; D010523:Peripheral Nervous System Diseases / Q000473:pathology*
D000682:Amyloid