MM 46115, a new antiviral antibiotic from Actinomadura pelletieri. Characteristics of the producing cultures, fermentation, isolation, physico-chemical and biological properties.
Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Gram-positive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.
Ashton
R J
RJ
SmithKline-Beecham-Pharmaceuticals, Epsom, Surrey, UK.
Kenig
M D
MD
Luk
K
K
Planterose
D N
DN
Scott-Wood
G
G
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D018942:Macrolides; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D009618:Nocardiaceae / Q000378:metabolism*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D018108:Respirovirus / Q000187:drug effects*; D014249:Trichophyton / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D018942:Macrolides; C066793:MM 46115