title: Radioisotopic and biochemical determination of salivary secretion after long term psychotropic therapy.
abstract: The aim of this work was to investigate the effect of prolonged psychotropic therapy (neuroleptics and antidepressants over 5 yr on salivary secretion. The flow rate in the parotid and submandibular glands were measured separately by scintigraphy. Flow rates, total protein concentration and total IgA level were determined in the unstimulated saliva in 30 control subjects and 73 patients treated with psychotropic drugs. As evidenced by measurement of flow rates and scintigraphy, psychotropic therapy reduced the unstimulated salivary secretion from parotid glands and to a lesser extent from submandibular gland. The scintigraphic study showed a lower response to stimulation in patients than controls.
authors.affiliation: Laboratoire de Physiopathologie et Biochimie Salivaire, Faculté d'Odontologie, Lyon, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Coudert
authors.forename: M
authors.initials: M
authors.lastname: Lissac
authors.forename: A
authors.initials: A
authors.lastname: Darmony
authors.forename: D
authors.initials: D
authors.lastname: Metrop
authors.forename: C
authors.initials: C
authors.lastname: Bejat
authors.forename: J O
authors.initials: JO
authors.lastname: Peyrin
authors.forename: J
authors.initials: J
authors.lastname: Parret
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D011619:Psychotropic Drugs / Q000009:adverse effects*; D011877:Radionuclide Imaging; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D013670:Sodium Pertechnetate Tc 99m; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
chemical_list: D011619:Psychotropic Drugs; D013670:Sodium Pertechnetate Tc 99m