title: [Synthesis and antihypertensive activity of some phenoxyalkylamine compounds].
abstract: Nine new compounds were synthesized and tested for their alpha-adrenoceptor affinity and antihypertensive activity together with 5 other previously reported compounds. Compounds I, IIa, IIb and IIIa showed high alpha-adrenoceptor affinity and strong antihypertensive activity.
authors.affiliation: China Pharmaceutical University, Naning.
authors.forename: L
authors.initials: L
authors.lastname: Xia
authors.forename: P Z
authors.initials: PZ
authors.lastname: Ni
authors.forename: W
authors.initials: W
authors.lastname: Song
authors.forename: G Q
authors.initials: GQ
authors.lastname: Liu
authors.forename: J Q
authors.initials: JQ
authors.lastname: Qian
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: F H
authors.initials: FH
authors.lastname: Du
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D008801:Mexiletine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D005021:Ethylamines; D011942:Receptors, Adrenergic, alpha; D008801:Mexiletine