Alpha-2 adrenergic receptor function in post-stroke depression.
The growth hormone (GH) response to desipramine was measured in ten patients meeting criteria for post-stroke depression (PSD), eight age-matched post-stroke (PS) non-depressed patients and eight healthy controls. Responses were significantly blunted in patients with PSD. These findings suggest diminished alpha-2 adrenoceptor function may be an important marker for PSD.
Barry
S
S
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Ireland.
Dinan
T G
TG
D000368:Aged; D002544:Cerebral Infarction / Q000150:complications*; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D003891:Desipramine; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011941:Receptors, Adrenergic / Q000502:physiology*
D011941:Receptors, Adrenergic; D013006:Growth Hormone; D003891:Desipramine