title: Fluoride in caries prevention: is the effect pre- or post-eruptive?
abstract: A longitudinal study of children from ages 7 to 18 showed that, if enamel lesions were included, the overall number was the same in fluoridated and non-fluoridated areas. However, a significant reducing effect of pre-eruptive fluoride could be seen in the number of dentinal lesions in a fluoridated area, provided that fluoride was also consumed post-eruptively for a considerable period of time. A precise estimation of both pre- and post-eruptive effects was obtained when teeth were classified according to their eruption time as related to the onset of water fluoridation. About 66% of the greatest reduction in pit and fissure caries came from pre-eruptive fluoride, while in smooth surfaces, this effect was reduced to 25%. In approximal surfaces, the reduction was due half to pre- and half to post-eruptive fluoride. Post-eruptive fluoride became more important with decreasing severity of caries attack. Thus, assuming a continuing decline in dental caries, the majority of such populations will benefit most from the use of topical fluorides. However, in high-risk groups, supplementation of pre-eruptive fluoride can still be of major importance.
authors.affiliation: Department of Community Dental Health and Epidemiology, Netherlands Institute for Preventive Health Care, Leiden.
authors.forename: A
authors.initials: A
authors.lastname: Groeneveld
authors.forename: A A
authors.initials: AA
authors.lastname: Van Eck
authors.forename: O
authors.initials: O
authors.lastname: Backer Dirks
mesh_terms: D002648:Child; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000473:pathology; D003804:Dentin / Q000473:pathology; D005457:Fluoridation; D006801:Humans; D008137:Longitudinal Studies; D013997:Time Factors; D014078:Tooth Eruption