A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.
Redondo
J M
JM
Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
Hata
S
S
Brocklehurst
C
C
Krangel
M S
MS
D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004262:DNA Restriction Enzymes; D003850:Deoxyribonuclease I; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D015321:Gene Rearrangement; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism; D010957:Plasmids; D011401:Promoter Regions, Genetic / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014162:Transfection
D009687:Nuclear Proteins; D011948:Receptors, Antigen, T-Cell; D015500:Chloramphenicol O-Acetyltransferase; D004262:DNA Restriction Enzymes; D003850:Deoxyribonuclease I