title: Structure and function of the Epstein-Barr virus BZLF1 protein.
abstract: Five DNA-binding sites for the Epstein-Barr virus BZLF1 protein have been identified within three of the early viral promoters, and four of these binding sites contain a consensus AP-1 site. The part of the BZLF1 protein required for sequence-specific DNA binding to one of these AP-1-like sites was identified by deletion mapping. Site-directed mutagenesis of this DNA target suggests that BZLF1 may work partly by overcoming a cellular repressor of viral transcription.
authors.affiliation: Ludwig Institute for Cancer Research, St. Mary's Hospital Medical School, London, England.
authors.forename: G
authors.initials: G
authors.lastname: Packham
authors.forename: A
authors.initials: A
authors.lastname: Economou
authors.forename: C M
authors.initials: CM
authors.lastname: Rooney
authors.forename: D T
authors.initials: DT
authors.lastname: Rowe
authors.forename: P J
authors.initials: PJ
authors.lastname: Farrell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002872:Chromosome Deletion; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D009710:Nucleotide Mapping; D015345:Oligonucleotide Probes; D010957:Plasmids; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D015534:Trans-Activators; D014158:Transcription, Genetic; D014162:Transfection; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C063676:BZLF1 protein, Herpesvirus 4, Human; D004268:DNA-Binding Proteins; D015345:Oligonucleotide Probes; D015534:Trans-Activators; D014764:Viral Proteins