L-tyrosine and L-tryptophan membrane transport in erythrocytes and antidepressant drug choice.
In the treatment of depression, when antidepressant drug choice is made according to alterations of erythrocyte membrane transport of L-tyrosine and L-tryptophan in the individual patient, the clinical results are superior to those obtained when drugs are prescribed according to the physician's judgment. This is demonstrated by comparing three experimental groups: I, 100 patients treated in relation to their L-tyrosine and L-tryptophan transport; II, 30 patients treated according to the clinician's experience; III, 38 subjects treated against the L-tyrosine and L-tryptophan transport indications. In these groups, the frequency of patients improved by more than 70% is 77%, 47%, and 16%, respectively.
Azorin
J M
JM
Clinique de Psychiatrie et de Psychologie Médicale C.H.U. Timone Marseille, France.
Bovier
P
P
Widmer
J
J
Jeanningros
R
R
Tissot
R
R
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D016666:Fluvoxamine; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008803:Mianserin / Q000627:therapeutic use; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D010091:Oximes / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011941:Receptors, Adrenergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D014364:Tryptophan / Q000097:blood*; D014443:Tyrosine / Q000097:blood*
D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D010091:Oximes; D010880:Piperidines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D008803:Mianserin; D014443:Tyrosine; D014364:Tryptophan; D016666:Fluvoxamine; D007099:Imipramine; C018181:indalpine