[Inhibitors of DNA topoisomerases].
DNA topoisomerases participate in various aspects of DNA metabolism by their unique catalytic activity of changing DNA topology. Inhibitors of bacterial topoisomerases are antibacterial agents and those inhibiting mammalian counterparts are antitumor agents. What kinds of antitopoisomerase chemicals we have, how they act on topoisomerases, and what is known about the resistance against those agents are briefly reviewed. Furthermore, future problems to be solved in cancer chemotherapy were mentioned.
Andoh
T
T
Aichi Cancer Center Research Institute, Laboratory of Biochemistry.
D000818:Animals; D000970:Antineoplastic Agents; D004247:DNA / Q000378:metabolism; D019833:Genistein; D007529:Isoflavones / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D013141:Spiro Compounds / Q000494:pharmacology; D013858:Thiobarbiturates / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D007529:Isoflavones; D007546:Isoquinolines; D013141:Spiro Compounds; D013858:Thiobarbiturates; D059004:Topoisomerase I Inhibitors; D004247:DNA; D019833:Genistein; C016660:fredericamycin A; C045459:merbarone