[The action of precursors of noradrenaline synthesis on the membrane receptors of the spinal neurons in the chick embryo].
Effect of noradrenaline precursors (L-alanine, L-phenylalanine, L-tyrosine, L-DOPA and dopamine) on glycine and NMDA receptors of freshly isolated spinal neurones of chick embryo were investigated by means of the whole cell patch-clamp and concentration clamp techniques. L-alanine and L-DOPA were found to be glycine agonists which can potentiate NMDA responses. L-tyrosine does not activate glycine receptor but potentiate NMDA one. L-phenylalanine and dopamine do not interact with both glycine and NMDA receptors.
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D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D004837:Epinephrine / Q000096:biosynthesis; D005998:Glycine / Q000502:physiology; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000096:biosynthesis*; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D000596:Amino Acids; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D005998:Glycine; D009638:Norepinephrine; D004837:Epinephrine
Deĭstvie predshestvennikov sinteza noradrenalina na membrannye retseptory spinal'nykh neĭronov kurinogo émbriona.