Human glomerular mesangial cells inactivate leukotriene B4 by reduction into dihydro-leukotriene B4 metabolites.
Due to its potent chemotactic properties leukotriene B4 is an important mediator of inflammatory reactions. Cultured human kidney mesangial cells converted exogenously added leukotriene B4 efficiently into three different more lipophilic metabolites, two of them probably representing dihydro-leukotriene B4 isomers. This represents an alternative metabolic pathway, in contrast to leukotriene B4 omega-oxidation found in human polymorphonuclear leukocytes. Both dihydro-leukotriene B4 isomers had nearly completely lost their ability to induce leukocyte chemotaxis as compared to leukotriene B4.
Kaever
V
V
Institutes of Molecular Pharmacology, Medical School, Hannover, F.R.G.
Bruuns
J
J
Wunder
J
J
Damerau
B
B
Zimmer
G
G
Fauler
J
J
Wessel
K
K
Floege
J
J
Topley
N
N
Radeke
H
H
D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D005920:Glomerular Mesangium / Q000378:metabolism*; D006801:Humans; D007975:Leukotriene B4 / Q000378:metabolism* / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism; D010084:Oxidation-Reduction
D007975:Leukotriene B4