title: Plasminogen activator activities in the ventral and dorsolateral prostatic lobes of aging Fischer 344 rats.
abstract: Plasminogen activator (PA) activities were measured in extracts of ventral and dorsolateral prostate lobes in Fischer 344 (F344) rats of different ages. Ventral prostates of 30-month-old animals demonstrated widespread epithelial atrophy, some foci of inflammation, intraglandular atypical hyperplasia and/or adenocarcinoma, and a marked increase in PA activities compared with younger animals. Both low- and high-molecular-weight forms of activator were found in zymograms and both forms of activator showed an increase at 30 months. However, the PA activity of the aged rats showed a greater resistance to amiloride inhibition, suggesting a greater relative increase in the tissue-type activator activity than that of urokinase. These changes were not observed in the dorsolateral prostate. The lobe-specific changes in activator activity appear related to dysplasia/neoplasia and not aging.
authors.affiliation: VA Medical Center, Minneapolis, MN 55417.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wilson
authors.forename: J V
authors.initials: JV
authors.lastname: Ditmanson
authors.forename: A A
authors.initials: AA
authors.lastname: Sinha
authors.forename: R D
authors.initials: RD
authors.lastname: Estensen
mesh_terms: D000375:Aging / Q000378:metabolism*; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D004247:DNA / Q000378:metabolism; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D010960:Plasminogen Activators / Q000378:metabolism*; D011467:Prostate / Q000033:anatomy & histology / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D011506:Proteins; D000584:Amiloride; D004247:DNA; D010447:Peptide Hydrolases; D010960:Plasminogen Activators