Antiviral agents of plant origin. II. Antiviral activity of scopadulcic acid B derivatives.
Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than scopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had in vitro therapeutic indexes larger than 7 and were considered to merit further investigation.
Hayashi
T
T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Hayashi
K
K
Uchida
K
K
Niwayama
S
S
Morita
N
N
D000998:Antiviral Agents; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004224:Diterpenes; C058658:scopadulcic acid B