Atrial natriuretic peptide receptors in cerebral microvessels and choroid plexus of spontaneously hypertensive rats.
Binding sites of atrial natriuretic peptide in the cerebral microvessels and choroid plexus of spontaneously hypertensive rats (SHR) and Wistar Kyoto control rats (WKY) were measured. In the microvessels, the number of ANP binding sites was lower in SHR than WKY, but there was no difference in affinity of binding sites for the ligand between SHR and WKY. In the choroid plexus, the number of ANP binding sites was lower and the affinity for the ligand was higher in SHR than in WKY. These results suggest that the physiological function regulated by the ANP receptors in the cerebral microvessels and choroid plexus were altered in hypertension and that ANP receptors in the cerebral microvessels and choroid plexus were differentially regulated.
Okazaki
M
M
Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Kobayashi
H
H
Kuroiwa
A
A
Izumi
F
F
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D002540:Cerebral Cortex / Q000098:blood supply*; D002831:Choroid Plexus / Q000378:metabolism*; D007700:Kinetics; D008833:Microcirculation / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013045:Species Specificity
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor