[Assay of serum collagen markers in chronic liver diseases and liver cancer].
In order to identify the most useful marker to diagnose hepatic fibrosis, type III procollagen peptide (P-III-P), laminin P1, and prolyl-hydroxylase (PH) in sera obtained from patients with liver diseases were simultaneously measured and compared with histological features of chronic hepatitis and with tumor size estimated on abdominal CT scan. Further more, the diagnostic accuracy of these markers was evaluated by using discriminant analysis. P-III-P and laminin P1 were closely correlated with the activity of chronic hepatitis. These two markers most accurately discriminated between the compensated stage of liver cirrhosis and the decompensated stage, and between liver cirrhosis and hepatocellular carcinoma. Laminin P1 was found to most clearly distinguish chronic hepatitis from liver cirrhosis. P-III-P was significantly correlated with the size of hepatocellular carcinoma. However, PH failed to discriminate among liver diseases, and showed no significant correlation with a liver tumor size. And none of the markers examined were correlated with a degree of hepatic fibrosis. From these results, the analysis of both serum P-III-P and laminin P1 is a useful approach to evaluate hepatic collagen metabolism.
Inoue
T
T
Department of Internal Medicine, Tokyo Senbai Hospital.
Funaki
N
N
Hatahara
T
T
Igarashi
S
S
Kaneko
E
E
Tanaka
H
H
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D002908:Chronic Disease; D003094:Collagen / Q000097:blood*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood; D011393:Procollagen-Proline Dioxygenase / Q000097:blood
D014408:Biomarkers, Tumor; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C055716:laminin P1; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase