Protection against lethal equine herpes virus type 1 (subtype 1) infection in hamsters by immune stimulating complexes (ISCOMs) containing the major viral glycoproteins.
An experimental ISCOM vaccine has been prepared from gradient purified equine herpes virus type 1 (EHV-1). Radiolabelling studies demonstrated that this vaccine contained all the major viral glycoproteins in relative amounts similar to those found in non-detergent disrupted viral preparations. This EHV-1 ISCOM vaccine generated fully protective responses in hamsters challenged with an otherwise lethal dose of the hamster-adapted EHV-1 strain RACH.
Cook
R F
RF
Department of Infectious Diseases, Animal Health Trust, Newmarket, Suffolk, UK.
O'Neill
T
T
Strachan
E
E
Sundquist
B
B
Mumford
J A
JA
D000276:Adjuvants, Immunologic; D000818:Animals; D006224:Cricetinae; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D008647:Mesocricetus; D008854:Microscopy, Electron; D011863:Radioimmunoassay; D014611:Vaccination; D014765:Viral Vaccines / Q000302:isolation & purification*
D000276:Adjuvants, Immunologic; D006023:Glycoproteins; D014765:Viral Vaccines