ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE.
We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha). The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2.
Watanabe
T
T
Department of Physiology, Yamaguchi University School of Medicine, Japan.
Morimoto
A
A
Sakata
Y
Y
Murakami
N
N
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000276:immunology / Q000378:metabolism*; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007267:Injections / Q000379:methods; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D007375:Interleukin-1; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D015232:Dinoprostone; D007213:Indomethacin