HIV-1-related thrombocytopenia.
Immunologic thrombocytopenia has recently been described in HIV-1 seropositive patients: homosexuals, narcotic addicts, hemophiliacs, and heterosexual partners of HIV-1 infected patients. All patients have markedly elevated platelet-bound IgG and C3C4 as well as circulating immune complexes. The immune complexes of homosexuals and narcotic addicts contain anti-F(ab') against anti-HIV-1 antibody. These are present in the serum and on the platelets, and could be responsible for the thrombocytopenia.
Karpatkin
S
S
New York University Medical School, Department of Medicine, New York.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000936:Antigen-Antibody Complex / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006467:Hemophilia A / Q000150:complications; D006716:Homosexuality; D006801:Humans; D008297:Male; D011379:Prognosis; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis; D012749:Sexually Transmitted Diseases / Q000635:transmission; D013156:Splenectomy; D019966:Substance-Related Disorders / Q000150:complications; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex