Metabolic studies on the hypolipidaemic effect of guar gum.
The hypolipidaemic effect of guar gum (30 g/day) was examined in a double blind placebo-controlled crossover study in 9 patients with primary hyperlipidaemia. The treatment periods were of six weeks duration. Cholesterol levels in low density lipoprotein (LDL) were decreased by 11.5% and in intermediate density lipoprotein (IDL) by 10.7%. Plasma cholesterol levels were reduced by 9.6% (P less than 0.05). Kinetic studies using autologous 125I-labelled LDL showed a decrease of 21.6% in plasma LDL apo B pool size (P less than 0.05) that resulted from a 39.1% increase in its fractional rate of catabolism. The kinetic effects of guar gum on LDL metabolism appear similar to that of bile acid binding resins in that LDL apo B fractional catabolism is greatly increased while there is a slight increase in production rate.
Turner
P R
PR
Division of Chemical Pathology, St. Thomas' Hospital, United Medical and Dental School, London, U.K.
Tuomilehto
J
J
Happonen
P
P
La Ville
A E
AE
Shaikh
M
M
Lewis
B
B
D000368:Aged; D004043:Dietary Fiber / Q000378:metabolism* / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D005685:Galactans / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D006995:Hypobetalipoproteinemias / Q000188:drug therapy* / Q000378:metabolism; D007009:Hypolipoproteinemias / Q000188:drug therapy*; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000493:pharmacokinetics; D008297:Male; D008351:Mannans / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D053149:Plant Gums; D016032:Randomized Controlled Trials as Topic
D004043:Dietary Fiber; D005685:Galactans; D008077:Lipoproteins, LDL; D008351:Mannans; D010919:Placebos; D053149:Plant Gums; C007894:guar gum