title: [The presence of HPV DNA in squamous metaplasia, dysplasia and carcinoma in situ of the uterine cervix].
abstract: HPV DNA was detected in 11% (4/36) of cervical squamous metaplasia, 43% (6/14) of mild dysplasia, 39% (7/18) of moderate dysplasia, 50% (7/14) of severe dysplasia and 50% (7/14) of CIS. The incidence of HPV16 DNA increased with the severity of dysplasia through CIS. It was distributed almost evenly in the nuclei of the total epithelial layers in severe dysplasia and CIS. Especially in CIS, HPV DNA was found significantly in the nuclei of both basal and parabasal cells, suggesting the possibility of involvement in the carcinogenesis of cervical cancer. The presence of HPV DNA in squamous metaplasia (36 cases) was investigated in three different pathological situations. Group 1 was squamous metaplasia in squamo-columnar junction; Group 2 in the polyp; and Group 3 accompanied by dysplasia or CIS. HPV DNA was positive only in squamous metaplasias with polyps. In these HPV DNA positive cases, HPV DNA was distributed not only in the metaplastic lesion, but also in the adjacent stromal lesion.
authors.affiliation: Department of Obstetrics and Gynecology, Sapporo Medical College.
authors.forename: S
authors.initials: S
authors.lastname: Shimano
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
mesh_terms: D002278:Carcinoma in Situ / Q000382:microbiology*; D002584:Cervix Uteri / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008679:Metaplasia / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae; D002578:Uterine Cervical Dysplasia / Q000382:microbiology*; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*
chemical_list: D004279:DNA, Viral