title: The role of limited surgery with irradiation in primary treatment of ductal in situ breast cancer.
abstract: The results of management of ductal carcinoma in situ with limited surgery and radiotherapy are presented at a median follow-up of 92 months. In 44 treated breasts the actuarial 10-year loco-regional control rate was 91%, four patients having recurred. Each loco-regional failure was due to invasive carcinoma and three of the affected patients have developed metastases. No patient developed metastases without previous clinically-evident invasive loco-regional disease. The 10-year disease-specific survival rate was 96%. Previous publications have shown that the 25% or greater risk of local failure after limited excision of ductal carcinoma in situ can be reduced by irradiation of the breast. Our results demonstrate that good loco-regional control is maintained in the longer term.
authors.affiliation: University of Texas M D Anderson Cancer Center, Houston 77030.
authors.forename: A T
authors.initials: AT
authors.lastname: Stotter
authors.forename: M
authors.initials: M
authors.lastname: McNeese
authors.forename: M J
authors.initials: MJ
authors.lastname: Oswald
authors.forename: F C
authors.initials: FC
authors.lastname: Ames
authors.forename: M M
authors.initials: MM
authors.lastname: Romsdahl
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002278:Carcinoma in Situ / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011379:Prognosis; D011867:Radioisotope Teletherapy
chemical_list: D003037:Cobalt Radioisotopes