title: Genomic DNA 5' to the mouse and human angiotensin-converting enzyme genes contains two distinct regions of conserved sequence.
abstract: Genomic DNA 5' to the mouse and human genes encoding angiotensin-converting enzyme has been isolated and analyzed. A sequence comparison identifies two discrete regions of genomic DNA that are highly conserved. One region, found immediately 5' to the mouse and human ACE genes, is a GC rich segment that contains a "TATA box" and several potential Spl binding sites. The second conserved region is found further 5' and contains several potential regulatory cis elements including a possible glucocorticoid responsive element. These two regions of genomic DNA may influence the rate of mRNA transcription from the angiotensin-converting enzyme gene.
authors.affiliation: Department of Pathology, Emory University, Atlanta, GA 30322.
authors.forename: S Y
authors.initials: SY
authors.lastname: Shai
authors.forename: K G
authors.initials: KG
authors.lastname: Langford
authors.forename: B M
authors.initials: BM
authors.lastname: Martin
authors.forename: K E
authors.initials: KE
authors.lastname: Bernstein
mesh_terms: D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D015723:Gene Library; D005796:Genes; D015698:Genomic Library; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D051379:Mice; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA; D007703:Peptidyl-Dipeptidase A