[Effects of piracetam on pain sensitivity and levels of beta-endorphin in blood and cAMP in the cerebral cortex of rats].
It has been shown, that piracetam by i.p. injection (10, 100, 400 mg/kg) or by consumption with drinking water 10, 100, 1000 mg/kg/day during 12 days delays extinction of conditioned reflex of passive avoidance and dose-dependence elevates exploratory activity in "open field", pain sensitivity threshold reduces to 70-75%. Prolonged consumption of 1000 mg/kg/day piracetam results in 3-fold decrease of beta-endorphin concentration in plasma (p less than 0.01) and 100 mg/kg/day--in 35% increase of cAMP content in rat brain cortex.
Vakulina
O P
OP
Iasnetsov
V V
VV
Isachenkov
V A
VA
Krylova
I N
IN
Tishkova
I P
IP
Bragin
E O
EO
Popkova
E V
EV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002540:Cerebral Cortex / Q000032:analysis*; D003214:Conditioning, Classical / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis*; D005106:Exploratory Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D010147:Pain Measurement / Q000187:drug effects*; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*
D011760:Pyrrolidinones; D001615:beta-Endorphin; D000242:Cyclic AMP; D010889:Piracetam
Vliianie piratsetama na bolevuiu chuvstvitel'nost', uroven' beta-éndorfina v krovi i tsAMF v kore golovnogo mozga krys.