title: Herpes simplex lymphadenitis. Report of two cases with review of the literature.
abstract: We report two cases of herpes simplex lymphadenitis without widespread organ involvement in a 60-year-old man and a 67-year-old woman. Their complaints were high fever and generalized erythema followed after few days by generalized lymphadenopathy. This report describes the findings obtained by light and electron microscopy, immunohistochemistry, and in situ hybridization. In both instances, Cowdry's type A intranuclear inclusion bodies were found in T-immunoblasts in the background of T-zone hyperplasia with focal necrosis. Electron microscopic investigation revealed intranuclear and cytoplasmic virus particles with characteristics of the herpes group. Immunohistochemical staining utilizing anti-herpes simplex virus (HSV) antibody was positive and in situ hybridization with HSV-DNA probe revealed positive signals in the nucleus and in the cytoplasm of T-immunoblasts. Although rare, HSV lymphadenitis in the absence of generalized infection can occur.
authors.affiliation: First Department of Pathology, Chiba University, School of Medicine, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tamaru
authors.forename: A
authors.initials: A
authors.lastname: Mikata
authors.forename: H
authors.initials: H
authors.lastname: Horie
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Asai
authors.forename: R
authors.initials: R
authors.lastname: Hondo
authors.forename: S
authors.initials: S
authors.lastname: Mori
mesh_terms: D000368:Aged; D000956:Antigens, Viral / Q000032:analysis; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D008199:Lymphadenitis / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000276:immunology / Q000648:ultrastructure
chemical_list: D000956:Antigens, Viral