title: [Expression of oncogenes by smooth muscle cells in atherosclerotic lesions].
abstract: Smooth muscle cells in the thickened intima of the aorta also expressed sis, mye, and c-fos, in addition to collagen types I, III, IV and type V. In the cultures of smooth muscle cells isolated from human aorta, collagen I, III and gelatinase were produced without any other special conditions for the culture. In the presence of PDGF, collagen type V and collagenase production was detected in the culture. Oncogene expression was not detected in the cultured cells when tested by the indirect immunofluorescence technique. Immortalized smooth muscle cells with SV 40 expressed myc, SV 40 large T antigen, and p53 without inhibition of collagen and collagenolytic enzymes production.
authors.affiliation: 2nd Department of Pathology, Kurume University of School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaguri
authors.forename: H
authors.initials: H
authors.lastname: Yanagi
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: R
authors.initials: R
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
mesh_terms: D001161:Arteriosclerosis / Q000235:genetics* / Q000473:pathology; D002453:Cell Cycle; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000473:pathology; D006801:Humans; D003012:Microbial Collagenase / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology*; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000502:physiology
chemical_list: D010982:Platelet-Derived Growth Factor; D003012:Microbial Collagenase