title: An immunohistochemical study of copper, zinc-containing superoxide dismutase detected by a monoclonal antibody gastric mucosa and gastric cancer.
abstract: The immunohistochemical localization of copper, zinc-superoxide dismutase (Cu,Zn-SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn-SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn-SOD. There was a relationship between the grade of Cu,Zn-SOD immunoreactivity and the histological type of gastric cancer, well-differentiated types of gastric cancer being more frequently positive. The positive cases of poorly-differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active oxygen species.
authors.affiliation: Kokura Memorial Hospital, Kitakyusyu, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: K
authors.initials: K
authors.lastname: Ogino
authors.forename: T
authors.initials: T
authors.lastname: Houbara
authors.forename: S
authors.initials: S
authors.lastname: Yoshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Okazaki
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Uda
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000201:enzymology / Q000473:pathology; D000911:Antibodies, Monoclonal; D005609:Free Radicals; D005753:Gastric Mucosa / Q000166:cytology / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia; D010100:Oxygen / Q000378:metabolism; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology; D013482:Superoxide Dismutase / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D005609:Free Radicals; D013482:Superoxide Dismutase; D010100:Oxygen