Preventive effect of aluminium citrate on silicosis.
Aluminium citrate (Al-cit) was shown to be biologically effective in preventing silicosis. A total of 917 cases selected from both engineering corps of railway and coalmines with stage 0 or 0+ by radiographs were studied. Cases were randomly divided into Al-cit treatment group and control group with continuing dust exposures. Workers in the treatment group were injected with Al-cit at a dose of 120 mg Al/year and these in the control group received a consolatant or nothing during the period of five years. The radiographic changes demonstrated that Al-cit showed clear-cut effects in both retardation of the dust-induced fibrosis and decrease of the morbidity of silicosis.
Zou
S Q
SQ
Department of Occupational Health, Beijing Medical University.
Liu
H
H
Zhou
Y Y
YY
Su
K Q
KQ
Qi
K Y
KY
Guan
S M
SM
Liu
S J
SJ
D000328:Adult; D000818:Animals; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D003031:Coal; D006801:Humans; D008297:Male; D008906:Mining; D011890:Railroads; D011897:Random Allocation; D051381:Rats; D012822:Silicon Dioxide; D012829:Silicosis / Q000209:etiology / Q000517:prevention & control*
D002951:Citrates; D003031:Coal; D019343:Citric Acid; D012822:Silicon Dioxide