title: The actions of 2-hydroxy-saclofen at presynaptic GABAB receptors in the rat hippocampus.
abstract: The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 microM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 microM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.
authors.affiliation: Department of Anesthesia and Critical Care, University of Chicago, IL 60637.
authors.forename: N L
authors.initials: NL
authors.lastname: Harrison
authors.forename: D M
authors.initials: DM
authors.lastname: Lovinger
authors.forename: N A
authors.initials: NA
authors.lastname: Lambert
authors.forename: T J
authors.initials: TJ
authors.lastname: Teyler
authors.forename: R
authors.initials: R
authors.lastname: Prager
authors.forename: J
authors.initials: J
authors.lastname: Ong
authors.forename: D I
authors.initials: DI
authors.lastname: Kerr
mesh_terms: D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011963:Receptors, GABA-A; D001418:Baclofen; C057491:2-hydroxysaclofen