Control of food intake by kainate/quisqualate receptors in the median raphe nucleus.
In previous studies we have reported that increases in food and water intake can be produced by microinjections of both NMDA selective and broad spectrum excitatory amino acid antagonists into the median raphe nucleus (MR). In the current experiments we examined the influence of kainate/quisqualate receptors in the MR on ingestive behavior. The consumption of food and water by deprived rats could be suppressed by intra-MR microinjections of the excitatory amino acid agonists kainic acid (5-10 ng in 0.5 microliters vehicle) and quisqualic acid (125-500 ng). Conversely, intra-raphe injections of the kainate/quisqualate receptor antagonists pBB-PZDA (1.25-2.5 micrograms) and GAMS (10-20 micrograms) elicited feeding in nondeprived animals. pBB-PZDA was more potent in eliciting ingestive behavior than was the selective NMDA antagonist 2-amino-6-phosphonohexanoic acid, suggesting that the effects of pBB-PZDA were not mediated through the NMDA receptor. The current findings suggest that ingestive behaviors are tonically inhibited by excitatory amino acids acting at kainate/quisqualate receptors in the vicinity of the MR.
Wirtshafter
D
D
Department of Psychology, University of Illinois, Chicago, 60680.
Krebs
J C
JC
D000818:Animals; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005973:Glutamine / Q000031:analogs & derivatives / Q000494:pharmacology; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009646:Norleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D016318:Quisqualic Acid; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*
D005973:Glutamine; D007608:Kainic Acid; D009646:Norleucine; D010069:Oxadiazoles; D010879:Piperazines; D016318:Quisqualic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C043094:2-amino-6-phosphonohexanoic acid; C042626:gamma-glutamylaminomethylsulfonic acid; C045883:1-(4-bromobenzoyl)piperazine-2,3-dicarboxylic acid