[The effect of oxytocin on the potential-activated calcium current in the neurons of the edible snail].
Effect of oxytocin and other peptides on the potential-activated calcium current was studied in neurons of the snail Helix pomatia under clamp conditions. It has been found that oxytocin inhibits the calcium current and ED50 of this process is about 9 x 10(-7) mol/l. Vasopressin has the same effect on the calcium current with ED50 about 8 x 10(-6) mol/l. Des-Gly-vasopressin exerts no noticeable effect on the calcium current. Possible mechanisms of the inhibitory effect of oxytocin on the calcium current are discussed.
Kononeko
N I
NI
Shcherbatko
A D
AD
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology*
D015220:Calcium Channels; D010121:Oxytocin
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