title: Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage.
abstract: The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.
authors.affiliation: Department of Experimental Research, University of Lund, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Alafaci
authors.forename: I
authors.initials: I
authors.lastname: Jansen
authors.forename: M A
authors.initials: MA
authors.lastname: Arbab
authors.forename: Y
authors.initials: Y
authors.lastname: Shiokawa
authors.forename: N A
authors.initials: NA
authors.lastname: Svendgaard
authors.forename: L
authors.initials: L
authors.lastname: Edvinsson
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology; D066298:In Vitro Techniques; D010455:Peptides / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents
chemical_list: D016232:Endothelins; D010455:Peptides; D014662:Vasoconstrictor Agents