title: Reactivity of human sera with overlapping synthetic peptides of herpes simplex virus type 1 glycoprotein D.
abstract: Thirty eight human sera, seropositive for herpes simplex virus (HSV) and 56 human sera, seronegative for HSV by immunofluorescence and by ELISA, were investigated for reactivity with a series of overlapping synthetic peptides of HSV type 1 glycoprotein D (gD-1). Thirty four out of the 38 human sera positive for HSV reacted with peptides located between residues 300 and 369; the HSV-negative sera reacted with six of the gD-1 peptides, but with none of the peptides within residues 300 to 369.
authors.affiliation: Laboratorium voor Medische Microbiologie, Rijksuniversiteit Groningen, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Geerligs
authors.forename: M
authors.initials: M
authors.lastname: Feijlbrief
authors.forename: M
authors.initials: M
authors.lastname: Bolk
authors.forename: C A
authors.initials: CA
authors.lastname: Bos
authors.forename: J W
authors.initials: JW
authors.lastname: Drijfhout
authors.forename: G W
authors.initials: GW
authors.lastname: Welling
authors.forename: S
authors.initials: S
authors.lastname: Welling-Wester
mesh_terms: D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D009500:Neutralization Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D010455:Peptides; D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1