title: [An ultrastructural and ultracytochemical study of peripheral blood thrombocytes in women with habitual spontaneous abortion].
abstract: An ultrastructural and ultracytochemical analysis of platelets was performed to assess the activity of 5'-AMPase and ATPase using a leukoconcentrate of the peripheral blood cells of non-pregnant women suffering from recurrent spontaneous abortion. The blood platelet populations were found to have increased proportions of light thrombocytes in phases I and II of the menstrual cycle, which was associated with pronounced ultrastructural and cytochemical signs of a release reaction showing their activated state: reduced density of the hyaloplasm, diminished quantity of specific and glycogen granules, development of the vacuolar system, 5'-AMPase and ATPase activity on the plasmalemma, light hyaloplasm, and in released specific granules and vacuoles. The release reaction is associated with a high contact activity of platelets which results in the formation of small and large platelet aggregates and attachment of other blood cells--erythrocytes, lymphocytes, and granulocytes. The intercellular fluid contains membrane fragments of destructive cells, including platelets with 5'-AMPase and ATPase activities, which may result in thromboplastin formation.
authors.forename: P D
authors.initials: PD
authors.lastname: Bonartsev
authors.forename: E M
authors.initials: EM
authors.lastname: Demidova
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D009708:Nucleotidases / Q000378:metabolism; D011247:Pregnancy
chemical_list: D009708:Nucleotidases; C018775:adenosine monophosphatase; D000251:Adenosine Triphosphatases
vernacular_title: Ul'trastrukturnoe i ul'tratsitokhimicheskoe issledovanie trombotsitov perifericheskoĭ krovi zhenshchin s privychnym nevynashivaniem beremennosti.