Dextromethorphan sites, sigma receptors, and the psychotomimetic effects of sigma opiates.
A review of the literature shows that the dysphoric and psychotomimetic side effects of opiate agonist-antagonist reside in the opiate levorotatory isomer. Thus, the current definition of the sigma receptor cannot explain the psychotomimetic effects of sigma opiates.
Musacchio
J M
JM
Department of Pharmacology, N.Y.U. School of Medicine, NY 10016.
Klein
M
M
Canoll
P D
PD
D000818:Animals; D001665:Binding Sites; D003915:Dextromethorphan / Q000378:metabolism* / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D006213:Hallucinogens; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D017480:Receptors, sigma; D013237:Stereoisomerism
D004723:Endorphins; D006213:Hallucinogens; D011957:Receptors, Opioid; D017480:Receptors, sigma; D007981:Levorphanol; D003915:Dextromethorphan