[Morphometric analysis of colorectal carcinoma and its clinical significance].
The clinical value of 5 parameters (DNAP, DNAS, NAS, NCR, CEAD) in colorectal carcinoma was studied in 80 cases with a 5-year follow-up history. Four of the parameters (DNAP, NAS, NCR, CEAD) were significantly higher in colorectal carcinoma than those in normal mucosa (P less than 0.01). This result seemed valuable for the quantitative pathologic diagnosis of colorectal carcinoma. Comparing with the group surviving for 5 years or longer, the group surviving for less than 5 years had a significantly higher DNAP and NCR (P less than or equal to 0.01). No clear correlation was found between DNAP and NCR or between these two parameters and clinicopathologic data including clinical stage, histopathologic grade and pathologic classification. This fact indicates that DNAP and NCR of colorectal carcinoma reflect the malignant level of the tumor. It is considered that DNAP and NCR are valuable, objective and predictive parameters for prognosis. As higher DNAP and NCR indicated higher malignancy.
Zhou
W G
WG
Oncology Research Laboratory, People's Hospital, Beijing Medical University.
D000230:Adenocarcinoma / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002467:Cell Nucleus / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D003593:Cytoplasm / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
D004273:DNA, Neoplasm