Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis.
Anti-Hu is an autoantibody that recognizes an antigen (Hu) highly restricted to neuronal nuclei. In the developing rat brain all neurons and the germinal cell layer were anti-Hu positive. Ependyma and choroid plexus were positive only in the early stages of development. The strongest expression of Hu was seen in the most mature neurons. The transitory nature of Cajal-Retzius and subplate neurons was confirmed with the anti-Hu staining. Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation.
Graus
F
F
Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.
Ferrer
I
I
D000375:Aging / Q000378:metabolism; D000818:Animals; D001323:Autoantibodies; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000276:immunology; D004679:Encephalomyelitis / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins