Human papillomavirus type 18 in conjunctival intraepithelial neoplasia.
Human papillomaviruses are oncogenic viruses that have been found in a variety of epithelial neoplasias. We sought to confirm their presence in conjunctival intraepithelial neoplasia. Five tumors were studied with a polymerase chain-reaction assay designed to detect the E6 region of human papillomavirus types 16 and 18. Human papillomavirus type-16 DNA was found in four of the five tumors, including two tumors that contained both type-16 and type-18 DNA. Viral DNA was not present in the fifth tumor.
Lauer
S A
SA
LSU Eye Center, New Orleans 70112.
Malter
J S
JS
Meier
J R
JR
D001345:Autoradiography; D002460:Cell Line; D002584:Cervix Uteri / Q000032:analysis / Q000166:cytology; D003230:Conjunctival Neoplasms / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005260:Female; D006367:HeLa Cells / Q000032:analysis; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction
D004279:DNA, Viral