Effects of neuropeptide Y on norepinephrine release in hypothalamic slices of spontaneously hypertensive rats.
We describe the effects of neuropeptide Y (NPY) on [3H]norepinephrine (NE) release from hypothalamic slices of spontaneously hypertensive rats (SHR). The electrical stimulation (1 Hz)-evoked [3H]NE release was significantly greater in hypothalamic slices of SHR than in those of Wistar Kyoto rats (WKY). NPY inhibited the stimulation-evoked [3H]NE release in a dose-dependent manner. The inhibitory effect of NPY was significantly attenuated in SHR compared with WKY. The results may indicate that the less inhibitory effect of NPY on NE release induces increased sympathetic nerve activity in the hypothalamus of SHR.
Tsuda
K
K
Neurochemistry Research Laboratories, New York University Medical Center, NY 10016.
Tsuda
S
S
Goldstein
M
M
Masuyama
Y
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D009435:Synaptic Transmission / Q000187:drug effects
D009478:Neuropeptide Y; D009638:Norepinephrine