title: Synthesis and benzodiazepine receptor binding of 1H-pyrrolo[2,1-C][1,4]benzothiazines.
abstract: The pyrrolo[2,1-c][1,4]benzothiazines 2a-n and the pyrrolo[2,1-c][1,4]thiazine 13 were prepared and tested for their ability to displace specific [3H]diazepam binding from rat brain membranes. Such compounds were found essentially devoid of binding affinity for the benzodiazepine receptor.
authors.affiliation: Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Trapani
authors.forename: A
authors.initials: A
authors.lastname: Latrofa
authors.forename: M
authors.initials: M
authors.lastname: Franco
authors.forename: G
authors.initials: G
authors.lastname: Liso
authors.forename: G
authors.initials: G
authors.lastname: Genchi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D011758:Pyrroles / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013843:Thiazines / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D011758:Pyrroles; D011963:Receptors, GABA-A; D013843:Thiazines