title: Acquired myasthenia gravis and cholangiocellular carcinoma in a dog.
abstract: Acquired myasthenia gravis and cholangiocellular carcinoma were diagnosed in a 7-year-old English Setter referred because of forelimb lameness, exercise-induced weakness, and fever. Three months earlier, the dog had had a pleuropulmonary infection caused by a Fusobacterium sp. The concurrent development of myasthenia gravis and cholangiocellular carcinoma in this dog may be explained by a paraneoplastic syndrome, although it is unproven. The cholangiocellular carcinoma may have possessed an acetylcholine receptor-like antigen on the tumor surface, which induced autoantibodies to cross-react with acetylcholine receptors at the neuromuscular junction.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011.
authors.forename: L J
authors.initials: LJ
authors.lastname: Krotje
authors.forename: A S
authors.initials: AS
authors.lastname: Fix
authors.forename: A D
authors.initials: AD
authors.lastname: Potthoff
mesh_terms: D002759:Adenoma, Bile Duct / Q000150:complications / Q000556:secondary / Q000662:veterinary*; D000818:Animals; D001650:Bile Duct Neoplasms / Q000150:complications / Q000662:veterinary*; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D005674:Fusobacterium Infections / Q000150:complications / Q000662:veterinary; D007794:Lameness, Animal / Q000209:etiology; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D009157:Myasthenia Gravis / Q000150:complications / Q000662:veterinary*; D012141:Respiratory Tract Infections / Q000150:complications / Q000662:veterinary