Hepatocellular carcinoma and bladder cancer as complications following five years of chemotherapy for acute myeloblastic leukemia.
Acute myeloblastic leukemia (AML) was diagnosed in a 54-year-old male, a chronic hepatitis B surface antigen (HBsAg) carrier, in June, 1983. Prompt remission was achieved, and maintenance and intensification chemotherapy were given for five years. He was readmitted in March, 1988 because of a mass in the liver and was diagnosed as having hepatocellular carcinoma (HCC). Curative right segmentectomy was performed in May, 1988. In December, 1988, transitional cell carcinoma of the bladder was discovered, and resected transurethrally. These secondary neoplasms, HCC and bladder cancer, were thought to be associated with the long-term chemotherapy given for the AML.
Hirota
Y
Y
Department of Internal Medicine, Matsuyama Red Cross Hospital, Japan.
Matsumoto
I
I
Aso
T
T
Kondou
S
S
Ikematsu
W
W
Hino
H
H
Nishiura
S
S
Yoneda
K
K
Shiraishi
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000382:microbiology / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000473:pathology; D003520:Cyclophosphamide / Q000009:adverse effects; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D006514:Hepatitis B Surface Antigens; D003520:Cyclophosphamide