[Experimental analysis of the neurobiological basis of genetically determined alcohol addiction in the progeny].
Experiments on 45 nonlinear albino male rats were made to investigate bioelectrogenesis of the limbic-neocortical parts of the brain, function of the systems of positive and negative reinforcement and emotional behavior of the progeny of long alcoholized animals with successive growth of the extent of alcoholism aggravation. Their different initial characteristics were discovered in intact rats as regards parents' alcoholism and in alcoholism aggravated rats, determining different mechanisms and rates of the development of pathological ethanol addiction. The pathogenic influence of "familial" alcoholism lies in the formation in the progeny of the first and fourth generations of the model of alcohol addiction anticipation, whose pathological integration is realized on the basis of the beforehand prepared model which becomes quantitatively different as a result of genetic anomalies.
Vorob'eva
T M
TM
Geĭko
V V
VV
D000437:Alcoholism / Q000209:etiology / Q000235:genetics* / Q000523:psychology; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000503:physiopathology; D008032:Limbic System / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008431:Maternal-Fetal Exchange; D009042:Motivation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology* / Q000523:psychology; D051381:Rats
D000431:Ethanol
Eksperimental'nyĭ analiz neĭrobiologicheskikh osnov vlecheniia k alkogoliu u potomstva, otiagoshchennogo alkogolizmom.