Effect of astragalus membranaceus on electric activities of cultured rat beating heart cells infected with Coxsackie B-2 virus.
Astragalus membranaceus (AM) which has a protective effect on rat beating heart cells infected experimentally with Coxsackie B-2 virus was evaluated on the basis of changes in morphologic and electric activity of the cells. Rhythm, beating frequency, beating percentage, cardiac cellular damage and cytopathic effects (CPE) were monitored every 24 h after challenge; electric activities parameters were measured by conventional intracellular microelectrode technique. Significant protective effects were demonstrated when AM was given in the early period of infection. The results suggest that AM should be valuable in preventing and treating acute myocarditis caused by Coxsackie B virus.
Yuan
W L
WL
Zhongshan Hospital, Shanghai Medical University.
Chen
H Z
HZ
Yang
Y Z
YZ
Yang
X Y
XY
Lin
Y S
YS
Jin
P Y
PY
Zhou
T S
TS
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D027885:Astragalus propinquus; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D029822:Enterovirus B, Human / Q000502:physiology*; D006321:Heart / Q000503:physiopathology*; D008839:Microelectrodes; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal