[Radionuclide assessment of cardiac involvement in patients with sarcoidosis].
This study was aimed to determine whether nuclear methods were useful for examining cardiac pathology and for making a decision of corticosteroid therapy in patients with sarcoidosis. Thirty six patients were divided into two groups; GpA consisted of 19 patients with cardiac sarcoidosis and abnormal ECG findings, and GpB of 17 patients with sarcoidosis without ECG abnormalities. Cardiac uptake of 67Ga-citrate in 2 and 99mTc-PYP in one of GpA was observed and steroid therapy resulted in the disappearance of the uptake. 201Tl-CL cardiac tomograms disclosed perfusion defects in 10 of 14 patients (71%) in GpA, including defects with redistribution in 8 of the 10 pts, but only one case in GpB. Radionuclide ventriculography using 99mTc-RBC revealed abnormal response of left ventricular (LV) function to exercise and LV dysfunction in GpA. These data suggest that nuclear study is a useful tool for diagnosing cardiac sarcoidosis, evaluating therapeutic effectiveness and long-term follow-up in patients with sarcoidosis.
Hiroe
M
M
Department of Radiology and Cardiology, Tokyo Women's Medical College.
Nagata
M
M
Sekiguchi
M
M
Ohta
Y
Y
Kusakabe
K
K
Shigeta
A
A
Horie
T
T
Fujita
N
N
Hasumi
M
M
Toyosaki
T
T
D000328:Adult; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000473:pathology; D011756:Diphosphates; D005260:Female; D005710:Gallium Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000473:pathology; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013794:Thallium Radioisotopes
D011756:Diphosphates; D005710:Gallium Radioisotopes; D013794:Thallium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium