[Once more a discussion of the RSV affair].
During autumn- and winter epidemics respiratory syncytial (RS) virus accounts for the majority of respiratory infections in infants and young children. In case of an acute lower respiratory tract infection, RS virus can induce serious symptoms. These are age-dependent. The most important symptoms in babies and toddlers are dyspnea, wheezing, cyanosis and apneas. In the case of respiratory insufficiency or fatigue, as well as recurrent apneas, mechanical ventilation is required. Diagnosis can be made using a direct immunofluorescence technique with monoclonal antibodies. To control the risk of nosocomial RS virus infections, isolation precautions are necessary. The overall mortality is low (less than 1%), but may be strikingly higher in children at risk: babies less than one month of age, preterm babies, infants with congenital heart- or pre-existent respiratory diseases, and those with severe immunodeficiency syndromes. In these subgroups therapy with ribavirin (Virazole) may be beneficial, although until now there is no strong evidence for the effectiveness of this antiviral agent. The majority of the children will have recurrent symptoms of dyspnea and wheezing over the subsequent years following the RS virus infection. In acute lower respiratory RS virus infection, there may be IgE mediated hypersensitivity reactions to viral agents, with release of chemical mediators of airway obstruction. The pathophysiological mechanisms might be comparable to those in patients with asthma.
Roorda
R J
RJ
afd. Kinderlongziekten, Kinderkliniek Academisch Ziekenhuis en Rijks Universiteit Groningen.
Schreuder
H
H
Van Aalderen
W M
WM
Gerritsen
J
J
Knol
K
K
D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007158:Immunologic Techniques; D007223:Infant; D012136:Respiratory Syncytial Viruses; D012141:Respiratory Tract Infections / Q000209:etiology*; D010253:Respirovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy
De RSV-affaire nogmaals besproken.