title: [A kinetic analysis of the alpha 1-adrenergic reaction of the smooth muscles in the rat vas deferens].
abstract: The kinetics of alpha 1-adrenergic response to noradrenaline was studied in isolated epididymal section of the rat vas deferens. Two discrete pools of alpha 1-adrenoreceptors differing by their affinity to noradrenaline, were revealed. The alpha 1-adrenoreceptors also differed from each other in their ability to interact with one or two molecules of the transmitter. Functional role of heterogeneity of the receptors is discussed.
authors.forename: B N
authors.initials: BN
authors.lastname: Manukhin
authors.forename: L V
authors.initials: LV
authors.lastname: Berdysheva
authors.forename: D Kh
authors.initials: DKh
authors.lastname: Khakimova
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
chemical_list: D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine
vernacular_title: Kineticheskiĭ analiz al'fa 1-adrenergicheskoĭ reaktsii gladkikh myshts semiavynosiashchego protoka krysy.