[The regulation of the spontaneous activity of the ureter by a Na+/Ca++-metabolic mechanism].
In presence of the specific Na(+)-K(+)-pump blocking agent ouabain reestablishment of spike activity of the ureter smooth muscle cells occurred, the latters having been preliminarily incubated in sodium-free solution. The reestablishment lasted not over 15 minutes. After substitution of calcium ions with barium ones, the period of the spike generation increased. The lithium ions are able to substitute the sodium ions for reestablishing the calcium action potentials. The ureter activity seems to be reestablished in sodium-free solution with participation of the Na+/Ca(++)-exchange mechanism, which is quite specific for the calcium ions.
Kazarian
K V
KV
Tiraian
A S
AS
Oganesian
A S
AS
Akopian
R R
RR
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010042:Ouabain / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014513:Ureter / Q000187:drug effects / Q000502:physiology*
D015220:Calcium Channels; D015222:Sodium Channels; D010042:Ouabain; D012964:Sodium; D002118:Calcium
Reguliatsiia spontannoĭ aktivnosti mochetochnika Na+/Ca++-obmennym mekhanizmom.