title: [Intraoperative radiotherapy (IORT) at the Graz University Clinics: results of a pilot study on non-small cell lung carcinoma].
abstract: A pilot study was undertaken during which 15 patients with non-small cell pulmonary carcinomas were exposed to an intraoperative irradiation; twelve out of them were submitted to an additional percutaneous photon therapy. The criteria used to select these patients were functional inoperability, exclusion of remote metastases, and a Karnofsky index greater than 70. Central and peripheral tumors of the stages T1-3, N0-2 were included into the study after histological confirmation of the diagnosis. The local regression rate of the primary tumor can be assessed quite well despite the short follow-up time of 4.5 to 16 months (10 months on an average) which does not yet allow to make a conclusion as to a prolongation of the disease-free survival time. Already two months after the end of external irradiation, a complete remission (CR) was seen in three patients (25%), a partial remission (PR) in seven patients (67%), and a minor remission (MR) in one patient. In the course of further follow-up, the number of complete remissions increased to six (50%). We are encouraged by the small morbidity and a therapeutic response higher than average to continue with this therapy method in patients who, for the time being, are still selected according to strict criteria.
authors.affiliation: Universitätsklinik für Radiologie, Abteilung für Strahlentherapie, Graz, Osterreich.
authors.forename: K
authors.initials: K
authors.lastname: Arian-Schad
authors.forename: H
authors.initials: H
authors.lastname: Leitner
authors.forename: F
authors.initials: F
authors.lastname: Smolle-Jüttner
authors.forename: A
authors.initials: A
authors.lastname: Hackl
authors.forename: G
authors.initials: G
authors.lastname: Porsch
authors.forename: H
authors.initials: H
authors.lastname: Pinter
authors.forename: G
authors.initials: G
authors.lastname: Friehs
mesh_terms: D000368:Aged; D001317:Austria; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D007430:Intraoperative Care; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011879:Radiotherapy Dosage; D013997:Time Factors
vernacular_title: Intraoperative Strahlentherapie (IORT) an den Universitätskliniken Graz: Ergebnisse einer Pilotstudie nichtkleinzelliger Lungenkarzinome.