[The effect of acetylcholine and serotonin on the adrenergic reaction of the rat small intestine].
Acetylcholine and serotonine depressed the sensitivity of the rat small intestine's receptors and enhanced the maximal alpha-adrenergic response. Acetylcholine acted as a competitive inhibitor of beta-adrenergic response, the latter being insensitive to serotonine. Acetylcholine even in the threshold concentrations (1.0 x 10(11) M) increased the noradrenaline desensitization of the adrenoreceptors.
Ledneva
I P
IP
Manukhin
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BN
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D013565:Sympatholytics / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
D011941:Receptors, Adrenergic; D013565:Sympatholytics; D013566:Sympathomimetics; D012701:Serotonin; D000109:Acetylcholine
Vliianie atsetilkholina i serotonina na adrenergicheskuiu reaktsiiu tonkoĭ kishki krysy.