Eosinophil and neutrophil production of leukotriene C4 and B4: comparison of cells from asthmatic subjects and healthy donors.
Production of LTC4 and LTB4 by eosinophils and neutrophils was compared between nine asymptomatic asthmatic subjects and eight healthy donors. We observed a statistically significant difference in LTC4 generated by eosinophils, but not LTB4 produced by neutrophils. These findings suggest a quantitative difference in eosinophils between asthmatic subjects and healthy donors.
Aizawa
T
T
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Tamura
G
G
Ohtsu
H
H
Takishima
T
T
D001249:Asthma / Q000378:metabolism / Q000473:pathology*; D002478:Cells, Cultured; D002845:Chromatography; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D009504:Neutrophils / Q000378:metabolism*; D012016:Reference Values; D013189:SRS-A / Q000096:biosynthesis*
D013189:SRS-A; D007975:Leukotriene B4