title: Remote, semiautomated production of 6-[18F]fluoro-L-dopa for human studies with PET.
abstract: Regioselective radiofluorodemercuration of the 6-mercurio derivative 5 with [18F]acetylhypofluorite afforded, after acidic hydrolysis, 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-FD, 1) with a radiochemical yield of 11% (decay corrected and based on the total amount of [18F]F2 recovered from the target). 6-FD was obtained with a chemical and radiochemical purity of greater than 99% and with a level of mercury in the final preparation of less than 20 ppb. Utilization of a remote, semiautomated production system, resulted in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min.
authors.affiliation: Department of Radiological Sciences, UCLA School of Medicine 90024.
authors.forename: A
authors.initials: A
authors.lastname: Luxen
authors.forename: M
authors.initials: M
authors.lastname: Perlmutter
authors.forename: G T
authors.initials: GT
authors.lastname: Bida
authors.forename: G
authors.initials: G
authors.lastname: Van Moffaert
authors.forename: J S
authors.initials: JS
authors.lastname: Cook
authors.forename: N
authors.initials: N
authors.lastname: Satyamurthy
authors.forename: M E
authors.initials: ME
authors.lastname: Phelps
authors.forename: J R
authors.initials: JR
authors.lastname: Barrio
mesh_terms: D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D006801:Humans; D007553:Isotope Labeling; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine