Effects of cytokines from virus-induced human lymphoblasts on the growth and viability of the promyelocytic leukemia cell line HL-60.
Cells of the human B-cell lymphoblastic leukemia line, BALL-1, were stimulated with Sendai virus. It is shown that the crude culture supernatants contain not only interferon-alpha (IFN-alpha) and tumor necrosis factor-alpha (TNF-alpha) but also other cytokines, here collectively termed 'X' cytokines. The latter did not affect the cytostatic or differentiation-inducing effect of IFN-alpha but synergistically increased the cytotoxicity of TNF-alpha.
Sueishi
S
S
Department of Virology, Okayama University School of Medicine, Japan.
Ando
S
S
Yamauchi
H
H
Oga
J
J
Ootsuka
Y
Y
Nagano
Y
Y
D002051:Burkitt Lymphoma / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism* / Q000382:microbiology; D010222:Parainfluenza Virus 1, Human / Q000502:physiology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D016207:Cytokines; D007370:Interferon Type I; D014409:Tumor Necrosis Factor-alpha