Receptor-mediated calcium entry.
Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage-operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor-mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by-passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn2+ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365.
Rink
T J
TJ
Physiological Laboratory, Cambridge, UK.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D004553:Electric Conductivity; D005456:Fluorescent Dyes; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
D015220:Calcium Channels; D005456:Fluorescent Dyes; D011956:Receptors, Cell Surface; D002118:Calcium