Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids.
A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagenase were examined. Both Z-Pro-Leu-Ala-NHOH and Z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC50 of 10(-6) M order.
Odake
S
S
Research Institute, Fuji Chemical Industries, Ltd., Toyama, Japan.
Okayama
T
T
Obata
M
M
Morikawa
T
T
Hattori
S
S
Hori
H
H
Nagai
Y
Y
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology
D009842:Oligopeptides; C064850:prolyl-leucyl-alanine hydroxamic acid; D003012:Microbial Collagenase