title: Transdermal nicotine facilitates smoking cessation.
abstract: The efficacy of a transdermal nicotine patch in facilitation of smoking cessation was evaluated in a randomized double-blind trial. Sixty-five smokers who were highly dependent on cigarettes participated in the study, which included a behavioral smoking-cessation program. The rates of continuous abstinence were significantly higher in the nicotine group both initially (55% versus 34%) and at 3 weeks (18% versus 6%). Certain smoking withdrawal symptoms, including negative affect and hypoarousal, were effectively relieved by the nicotine patch. There was a trend toward a reduction in cigarette craving, whereas hunger and habit withdrawal symptoms were not affected. The main side effect associated with the nicotine patch was skin irritation. These findings suggest that a nicotine skin patch may be a useful aid to smoking cessation; however, the combination of other techniques with nicotine replacement may provide a more effective treatment for symptoms such as craving for cigarettes.
authors.affiliation: Department of Psychiatry, Duke University, Durham, NC.
authors.forename: J E
authors.initials: JE
authors.lastname: Rose
authors.forename: E D
authors.initials: ED
authors.lastname: Levin
authors.forename: F M
authors.initials: FM
authors.lastname: Behm
authors.forename: C
authors.initials: C
authors.lastname: Adivi
authors.forename: C
authors.initials: C
authors.lastname: Schur
mesh_terms: D000279:Administration, Cutaneous; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D000074606:Smoking Prevention; D014029:Tobacco Use Disorder / Q000523:psychology*
chemical_list: D009538:Nicotine