Relationship between the cortical choline acetyltransferase content and EEG delta-power.
Destruction of the nucleus basalis abolished normal spectral power only in the frontal cortex, where choline acetyltransferase (ChAT) activity was lower. In lesioned animals, delta-power was increased and alpha-power decreased. The increase in delta-power during immobility correlated with a reduction in ChAT activity. High-voltage spindles occurred more frequently after cholinergic denervation. The results suggest that spectral power and high-voltage spindle analysis might serve as a useful tool for evaluating the efficacy of pharmacological strategies aimed at alleviating the cholinergic deficit.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Riekkinen
P
P
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000502:physiology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000201:enzymology / Q000502:physiology*; D004569:Electroencephalography; D008297:Male; D009068:Movement / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D002795:Choline O-Acetyltransferase