Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells.
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.
Williamson
J S
JS
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
Stohlman
S A
SA
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology*; D016827:CD8 Antigens; D002490:Central Nervous System / Q000382:microbiology; D005434:Flow Cytometry; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000382:microbiology; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains; D006517:Murine hepatitis virus / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens