Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
Hsu
D H
DH
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
de Waal Malefyt
R
R
Fiorentino
D F
DF
Dang
M N
MN
Vieira
P
P
de Vries
J
J
Spits
H
H
Mosmann
T R
TR
Moore
K W
KW
D000818:Animals; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10; D007378:Interleukins / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D015531:Radioimmunoprecipitation Assay; D013601:T-Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
C066460:BCRF1 protein, Human herpesvirus 4; D004279:DNA, Viral; D007378:Interleukins; D014764:Viral Proteins; D016753:Interleukin-10