Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus.
Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N-methyl-D-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, suggesting that NMDA receptors may contribute to the resting activity of MVN neurons.
Smith
P F
PF
Department of Psychology, University of Otago, Dunedin, New Zealand.
Darlington
C L
CL
Hubbard
J I
JI
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D006168:Guinea Pigs; D010879:Piperazines / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*; D014726:Vestibular Nuclei / Q000378:metabolism / Q000502:physiology*
D003986:Dibenzocycloheptenes; D010879:Piperazines; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D016291:Dizocilpine Maleate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid