[Computer study of pathologic factors influencing survival in colorectal carcinoma--a multivariant stepwise discriminant analysis].
Five quantitative pathologic parameters and three clinicopathologic parameters in 80 colorectal carcinoma patients with different prognosis were studied with a multivariant stepwise discriminant analysis on computer. The results showed that DNA index (DI), nucleocytoplasmic ratio (NCR), histologic grade and Dukes' stage were significant factors influencing the survival. With these factors, a 4-variable Fisher's discriminant function was established, which could correctly identify 81.25% and 83.75% of the predicted cases (Jacknife Procedure and Reclassification) Sensitivity of the two methods was 87.80%. The results indicate that the multivariant stepwise discriminant analysis on quantitative pathologic parameters combined with clinicopathologic parameters is of value in predicting prognosis of colorectal carcinoma patients.
Zhou
W
W
People's Hospital, Beijing Medical College.
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000473:pathology; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D003201:Computers; D004273:DNA, Neoplasm / Q000032:analysis; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
D004273:DNA, Neoplasm