title: Sex differences in adrenocortical structure and function. XXVII. The effect of ether stress on ACTH and corticosterone in intact, gonadectomized, and testosterone- or estradiol-replaced rats.
abstract: Studies were performed on the reactivity of the hypothalamo-pituitary-adrenocortical axis of intact, gonadectomized, and testosterone- or estradiol-replaced rats to standard ether stress. Plasma ACTH and corticosterone (B) levels, anterior pituitary ACTH, and adrenal B content were estimated 20 and 40 min after stress application and in unstressed animals. Ether stress resulted in an increase in plasma ACTH and B levels and in adrenal B content while pituitary ACTH content was notably lower when compared with unstressed rats. The response was markedly higher in female than in male rats. After orchiectomy and testosterone replacement, plasma ACTH and B responses to ether stress were similar to those observed in intact male rats. On the other hand, ovariectomized females responded to ether stress like intact males, while after estradiol replacement the pattern of plasma ACTH and B concentration and adrenal B content was similar to that in intact female rats. Thus, the higher responsiveness of the pituitary-adrenal cortex axis of female rats to ether stress depends on stimulatory or facilitatory effect of estradiol.
authors.affiliation: Department of Histology and Embryology, Poznań Academy of Medicine, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Leśniewska
authors.forename: B
authors.initials: B
authors.lastname: Miśkowiak
authors.forename: M
authors.initials: M
authors.lastname: Nowak
authors.forename: L K
authors.initials: LK
authors.lastname: Malendowicz
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000378:metabolism; D000818:Animals; D002369:Castration; D003345:Corticosterone / Q000097:blood* / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology; D004986:Ether / Q000633:toxicity; D005260:Female; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013312:Stress, Physiological / Q000139:chemically induced / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D004986:Ether; D013739:Testosterone; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone