title: A case of thyrotropin (TSH)-secreting tumor complicated by periodic paralysis.
abstract: A 27-year-old man had symptoms of hyperthyroidism and periodic paralysis. While hyperthyroid, his serum thyrotropin (TSH) level was inappropriately elevated at 6.4 microU/ml. The serum alpha subunit level was also elevated. MR imaging revealed a pituitary tumor and transsphenoidal adenomectomy was performed. Immunocytochemistry with an antibody directed against the beta-subunit of TSH revealed a TSH-secreting tumor. This is the first case of hyperthyroidism due to a TSH-secreting pituitary tumor complicated by periodic paralysis. This association indicates that thyrotoxicosis may induce paralysis in susceptible persons by a mechanism which is not autoimmune.
authors.affiliation: Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
authors.forename: Y
authors.initials: Y
authors.lastname: Kiso
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kaise
authors.forename: N
authors.initials: N
authors.lastname: Kaise
authors.forename: T
authors.initials: T
authors.lastname: Masuda
authors.forename: N
authors.initials: N
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Sakurada
authors.forename: K
authors.initials: K
authors.lastname: Yoshinaga
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010243:Paralysis / Q000150:complications*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine