Presynaptic receptors in hypertension.
The physiological status of presynaptic receptors, regulating sympathetic neurotransmitter release, remains subject to debate. Nevertheless, pharmacological techniques have shown presynaptic alpha-adrenoceptors, mediating a negative feedback inhibition of neuronal noradrenaline (NA) release, and presynaptic beta-adrenoceptors mediating a positive feedback facilitation. Decreased presynaptic alpha- or increased beta-adrenoceptor responsiveness might be expected to result in enhanced per-pulse release of NA and may contribute to hypertension development and maintenance. A potential role in hypertension development, but not its maintenance, has been established for presynaptic beta-adrenoceptors. Attempts to identify altered presynaptic adrenoceptor responsiveness in hypertension have, however, been inconclusive.
Borkowski
K R
KR
Clinical Pharmacology Group, John P. Robarts Research Institute, London, Ontario, Canada.
D000818:Animals; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D017981:Receptors, Neurotransmitter; D009638:Norepinephrine