The Pavlovian conditioning of IL-1-induced glucocorticoid secretion.
Recombinant IL-1-beta, which is capable of stimulating the pituitary-adrenal axis to secrete corticosterone, was paired with environmental cues in either a taste aversion or odor conditioning procedure. Among mice receiving paired delivery of cues and IL-1, subsequent re-exposure to cues elicited corticosterone production. This response was significantly greater than in animals that were conditioned but not re-exposed to the cues or were exposed to the cues alone. These results indicate that the IL-1 activation of adrenal cortical secretion can be conditioned to environmental stimuli.
Dyck
D G
DG
Department of Psychology, University of Manitoba, Winnipeg, Canada.
Janz
L
L
Osachuk
T A
TA
Falk
J
J
Labinsky
J
J
Greenberg
A H
AH
D000818:Animals; D002712:Chlorides; D003213:Conditioning, Psychological / Q000502:physiology*; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D005260:Female; D007165:Immunosuppression Therapy; D007375:Interleukin-1 / Q000494:pharmacology*; D008094:Lithium; D018021:Lithium Chloride; D051379:Mice; D008811:Mice, Inbred DBA; D009812:Odorants; D011598:Psychoneuroimmunology; D012439:Saccharin; D013649:Taste
D002712:Chlorides; D007375:Interleukin-1; D008094:Lithium; D012439:Saccharin; D018021:Lithium Chloride; D003345:Corticosterone