Heterogeneity of islet cell autoantibodies in terms of insulin release from rat islets and insulinoma cells.
The clinical significance of cytoplasmic islet cell autoantibodies (ICA) has been studied since their discovery by Bottazzo et al. in 1974. Some ICAs destroy pancreatic B cells in the presence of complement, whereas others take no part in this destruction. This suggests that islet function varies with the amount of ICA produced. In the present investigation we report the heterogeneity of monoclonal islet cell antibodies produced by one of us in terms of insulin release from isolated rat islets as well as from rat insulinoma cells (RINr).
Ejiri
K
K
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Taniguchi
H
H
Morimoto
Y
Y
Yamashiro
Y
Y
Baba
S
S
Srikanta
S
S
Eisenbarth
G S
GS
D007516:Adenoma, Islet Cell / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D002460:Cell Line; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007340:Insulinoma / Q000276:immunology* / Q000378:metabolism; D007515:Islets of Langerhans / Q000276:immunology* / Q000378:metabolism; D008297:Male; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007328:Insulin; C024211:islet cell antibody