Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11----q21 segment of chromosome 6.
Several studies point to the possibility that malignant hyperthermia (MH) in pigs is caused by a defect in the calcium release channel (CRC) of skeletal muscle sarcoplasmic reticulum. The locus for MH is closely linked to the glucosephosphate isomerase (GPI) locus, near the centromere of chromosome 6. We demonstrate synteny of the genes for CRC and GPI using somatic cell hybrid lines, and assign the CRC gene to chromosome 6p11----q21 by in situ hybridization.
Harbitz
I
I
Department of Biochemistry, Norwegian College of Veterinary Medicine, Oslo.
Chowdhary
B
B
Thomsen
P D
PD
Davies
W
W
Kaufmann
U
U
Kran
S
S
Gustavsson
I
I
Christensen
K
K
Hauge
J G
JG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015220:Calcium Channels / Q000235:genetics*; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006822:Hybrid Cells; D008305:Malignant Hyperthermia / Q000235:genetics / Q000662:veterinary*; D051379:Mice; D008969:Molecular Sequence Data; D013552:Swine / Q000235:genetics*; D013553:Swine Diseases / Q000235:genetics*
D015220:Calcium Channels; D015342:DNA Probes; D004247:DNA