title: Neutron capture therapy beam design at Harwell.
abstract: At Harwell, we have progressed from designing, building, and using small-diameter beams of epithermal neutrons for radiobiology studies to designing a radiotherapy facility for the 25-MW research reactor DIDO. The program is well into the survey phase, where the main emphasis is on tailoring the neutron spectrum. The incorporation of titanium and vanadium in an aluminium spectrum shaper in the D2O reflector has been shown to yield a significant reduction in the mean energy of neutrons incident on the patient by suppression of streaming through the cross-section window in aluminium at 25 keV.
authors.affiliation: Materials Physics and Metallurgy Division, Harwell Laboratory, Oxon, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Constantine
mesh_terms: D000535:Aluminum; D001932:Brain Neoplasms / Q000532:radiotherapy; D005160:Facility Design and Construction; D005909:Glioblastoma / Q000532:radiotherapy; D006801:Humans; D009010:Monte Carlo Method; D009502:Neutrons / Q000627:therapeutic use*; D009688:Nuclear Reactors / Q000295:instrumentation*; D014025:Titanium; D014639:Vanadium
chemical_list: D014639:Vanadium; D000535:Aluminum; D014025:Titanium