[Hypofunction of peripheral target-gland after radiotherapy of pituitary adenoma--an analysis of 140 cases].
One hundred and forty cases of pituitary adenoma, treated by surgery plus radiotherapy or radiotherapy alone from 1978 to 1985, were analysed as to the incidence of hypothalamo-pituitary and peripheral target-gland hypofunction after radiotherapy. The incidence of hypothyroidism, hypogonadism and hypoadrenalism was 51.7%, 61.4% and 17.8%, respectively. Thyroid and gonad were vulnerable following hypothalamo-pituitary hypofunction, and the incidence was 19.2% and 23.5% individually, and 27.1% simultaneously. The incidence of hypoadrenalism was 7.1%. The total incidence of target-gland hypofunction was 10.7%. Hypofunction of the posterior lobe of the pituitary often occurred after operation. For patients treated with radiotherapy alone, the incidence of hypothalamo-pituitary and target-gland hypofunction was high because of higher irradiation dose. Hormonotherapy was successful in the treatment of hypopituitarism and target-gland hypofunction. For radiotherapy of pituitary adenoma, DT 40-45 Gy and treatment field 4 x 4 cm are recommended.
Cui
S X
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General Hospital, PLA.
D000236:Adenoma / Q000532:radiotherapy* / Q000601:surgery; D000239:Adenoma, Acidophil / Q000532:radiotherapy* / Q000601:surgery; D000238:Adenoma, Chromophobe / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000209:etiology*; D007030:Hypothalamo-Hypophyseal System / Q000528:radiation effects; D007037:Hypothyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010910:Pituitary Irradiation / Q000009:adverse effects*; D010911:Pituitary Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010913:Pituitary-Adrenal System / Q000528:radiation effects