Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices).
Dibenzocycloalkenimine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, induced a concentration-dependent accumulation of inositol monophosphate in rat cerebral cortical slices. This effect appears unrelated to antagonism of NMDA receptors as AP-7 and PCP did not cause comparable effects. In addition, the MK-801-induced response was unaffected by NMDA or glycine, alone or in combination, Zn2+, or the removal of Mg2+ from the buffer. These results indicate a novel site of action for MK-801 associated with activation of phosphoinositide hydrolysis.
Ormandy
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Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham 35294.
Li
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Jope
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D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D010622:Phencyclidine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000494:pharmacology
D000596:Amino Acids; D010716:Phosphatidylinositols; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; D001285:Atropine; D008274:Magnesium; D010622:Phencyclidine; D015032:Zinc; C031231:2-amino-7-phosphonoheptanoic acid; D011224:Prazosin