title: Complement fixation test for the diagnosis of Lyme disease.
abstract: Sera from 43 patients were tested for complement-fixing antibodies to Borrelia burgdorferi; these patients included 8 with confirmed Lyme disease, 21 who were serologically positive but not likely to have Lyme disease, and 14 who were serologically negative. Seven individuals, all confirmed Lyme disease patients, had complement-fixing antibodies. Complement fixation may be a useful confirmatory test for Lyme disease.
authors.affiliation: Department of Microbiology, University of Toronto, Ontario, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Artsob
authors.forename: S
authors.initials: S
authors.lastname: Huibner
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D003168:Complement Fixation Tests; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis*
chemical_list: D000907:Antibodies, Bacterial