The significance of HIV-1-indeterminate western blot results in blood donor populations.
Until recently it has been difficult to counsel blood donors with human immunodeficiency virus-1 (HIV-1)-indeterminate Western blot results due to a lack of information concerning the significance of this finding. Reports from several investigators have provided laboratory, epidemiologic, and prospective follow-up data that have clarified the potential significance of this laboratory finding. It has been established that the band patterns observed in an HIV-1-indeterminate Western blot result are important in predicting the significance of the result; specifically, the absence of p24 or envelope glycoprotein reactivity has not been associated with HIV-1 infection, whereas the presence of p24 reactivity has infrequently been the first sign of HIV-1 seroconversion. These data provide the basis for formulating policies concerning the notification and counseling of blood donors with HIV-1-indeterminate Western blot patterns.
Kleinman
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American Red Cross Blood Services, Los Angeles, Orange Counties Region, CA 90006.
D001782:Blood Donors; D015153:Blotting, Western; D005500:Follow-Up Studies; D015488:HIV Antigens / Q000032:analysis; D015658:HIV Infections / Q000175:diagnosis*; D006679:HIV Seropositivity / Q000175:diagnosis; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D012192:Retroviridae Infections / Q000175:diagnosis; D014481:United States
D015488:HIV Antigens