Depression and potentiation of the synaptic transmission between a granule cell and a Purkinje cell in rat cerebellar culture.
Both the depression and the potentiation of synaptic transmission between a cerebellar granule cell and a Purkinje cell, which are considered the cellular basis of motor learning, were established in a simple culture preparation. The repetitive stimulation of both a granule cell and an inferior-olivary neuron depressed the synaptic transmission, and the repetitive stimulation of only a granule cell potentiated the transmission. Thus, a simple model system, where detailed analysis of molecular and cellular mechanisms of synaptic plasticities can be performed, has been established.
Hirano
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Department of Physiology, School of Medicine, Gunma University, Japan.
D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology*; D004558:Electric Stimulation; D004594:Electrophysiology; D009473:Neuronal Plasticity; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission