title: Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus.
abstract: Comparative nucleotide sequence analyses of the genome of Sendai virus (strain Z) and two host range mutants, ts-f1 and F1-R, previously described revealed that the ts defect of ts-f1 can be attributed to two nucleotide exchanges in the NP gene. These exchanges lead to a single amino acid substitution. A single base pair change was found in both the P and L genes of F1-R, but not of ts-f1. Both host range mutants have the two same exchanges in the M gene. These additional mutations are discussed concerning their significance in the pantropic properties of the host range mutants.
authors.affiliation: Department of Microbiology, California State University, Los Angeles 90032.
authors.forename: Y
authors.initials: Y
authors.lastname: Middleton
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
authors.forename: T
authors.initials: T
authors.lastname: Thai
authors.forename: J
authors.initials: J
authors.lastname: Oh
authors.forename: J
authors.initials: J
authors.lastname: Seymour
authors.forename: E
authors.initials: E
authors.lastname: Pritzer
authors.forename: H D
authors.initials: HD
authors.lastname: Klenk
authors.forename: R
authors.initials: R
authors.lastname: Rott
authors.forename: J T
authors.initials: JT
authors.lastname: Seto
mesh_terms: D000818:Animals; D001483:Base Sequence; D012321:DNA-Directed RNA Polymerases; D015707:HN Protein / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D010222:Parainfluenza Virus 1, Human / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D014758:Viral Core Proteins / Q000235:genetics; D014763:Viral Matrix Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D015707:HN Protein; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; C055859:P protein, Sendai virus; D010750:Phosphoproteins; D012367:RNA, Viral; D014758:Viral Core Proteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C064365:L protein, Sendai virus; D012321:DNA-Directed RNA Polymerases