Hepatitis B virus-associated hepatocellular carcinoma in African patients.
We have examined several tumors from South African patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma for the presence of integrated viral DNA. In contrast with our findings in patients from Taiwan, few copies of the viral genome were integrated in each tumor. Furthermore, Southern hybridization showed similarities in integration patterns between different tumors. We are presently constructing genomic libraries from selected single-copy tumors in order to make a more detailed analysis of HBV DNA integration at the molecular level.
Harrison
T J
TJ
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, U.K.
Lin
Y
Y
Stamps
A C
AC
Dusheiko
G M
GM
Zuckerman
A J
AJ
D000349:Africa; D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000382:microbiology*; D002681:China; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D015698:Genomic Library; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000382:microbiology*; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm; D004279:DNA, Viral