title: Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid-potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment.
abstract: In this study, we demonstrated that tissue inhibitor of metalloproteinases (TIMP) produced by human bone marrow stromal cell line KM-102 had erythroid-potentiating activity (EPA) which stimulates the proliferation of erythroid progenitor cells. We, then, propose a scheme for the bifunctional role of TIMP/EPA in hematopoietic microenvironment, that is, the maintenance of the integrity of bone marrow matrix and the proliferation of erythroid progenitor cells proceeding on the matrix.
authors.affiliation: Department of Biochemistry, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: J
authors.initials: J
authors.lastname: Kishi
authors.forename: K
authors.initials: K
authors.lastname: Harigaya
mesh_terms: D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002455:Cell Division; D015672:Erythroid Precursor Cells / Q000166:cytology*; D004920:Erythropoiesis; D006023:Glycoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D003012:Microbial Collagenase / Q000378:metabolism; D008970:Molecular Weight; D019714:Tissue Inhibitor of Metalloproteinases
chemical_list: D006023:Glycoproteins; D019714:Tissue Inhibitor of Metalloproteinases; D003012:Microbial Collagenase