Plasma and intracellular Mg2+ concentrations in pre-eclampsia.
Plasma and intra-erythrocytic magnesium concentrations were determined in 27 patients with pre-eclampsia and in 22 healthy pregnant women. In the pre-eclamptic women, the Mg2+ concentrations were measured before and after treatment with Mg2+ salts and after delivery. The plasma Mg2+ concentration was not significantly different in the pre-eclamptic and the healthy pregnant women. The intra-erythrocytic Mg2+ concentration before treatment with Mg2+ was significantly lower in the pre-eclamptic patients than in the healthy pregnant women [1.33 +/- 0.29 versus 1.01 +/- 0.16 mmol/l (means +/- s.d.); P less than 0.05] and increased after treatment with Mg2+ to 1.19 +/- 0.24 mmol/l. Lowered cellular Mg2+ concentrations in pre-eclampsia may contribute to the development of hypertension in this disorder.
Kisters
K
K
Medizinische Universitäts-Poliklinik, Münster, Federal Republic of Germany.
Niedner
W
W
Fafera
I
I
Zidek
W
W
D000328:Adult; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D007424:Intracellular Fluid / Q000032:analysis; D008274:Magnesium / Q000097:blood*; D010949:Plasma / Q000032:analysis; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D008274:Magnesium