Magnetic resonance imaging (MRI) effects on rat pineal neuroendocrine function.
This study investigated the effects of MRI on receptor-mediated activation of pineal gland indole biosynthesis. Exposure of rats to MRI reduced the effects of isoproterenol on pineal serotonin and N-acetylserotonin levels suggesting that strong magnetic fields and/or radio-frequency pulsing used in MRI inhibited beta-adrenergic activation of the gland. There was no effect of MRI on saline controls.
LaPorte
R
R
Department of Anatomy, Loyola University Stritch School of Medicine, Maywood, IL 60153.
Kus
L
L
Wisniewski
R A
RA
Prechel
M M
MM
Azar-Kia
B
B
McNulty
J A
JA
D000818:Animals; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D007545:Isoproterenol / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D008297:Male; D010870:Pineal Gland / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D007545:Isoproterenol