title: Frequent detection of hepatitis C virus US strain in Japanese hemophiliacs.
abstract: Hemophiliacs have been found to be at high risk of hepatitis. Hemophiliacs in Japan receive imported clotting factors as well as domestic ones. Recently we found that hepatitis C virus (HCV) could be classified into at least two types, HCV-US and HCV-J, depending on the nucleotide sequence. We analyzed the nucleotide sequences of virus RNAs from the plasma of patients with hemophilia A or B and found HCV-US in 3 of 4 Japanese hemophiliacs examined.
authors.affiliation: Virology Division, National Cancer Center Research Institute, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Hijikata
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Ootsuyama
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
authors.forename: S
authors.initials: S
authors.lastname: Ohkoshi
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Meguro
authors.forename: M
authors.initials: M
authors.lastname: Taki
mesh_terms: D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D006467:Hemophilia A / Q000150:complications / Q000382:microbiology*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000209:etiology*; D006801:Humans; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis*; D065227:Transfusion Reaction; D014481:United States
chemical_list: D012367:RNA, Viral