[Development of an inactivated vaccine for the protection of cattle against Aujeszky's disease].
The effects of an inactivated strain of Aujeszky's disease vaccine in cattle were investigated. It has not been possible to use vaccines licensed for use in pigs successfully in cattle even though cattle develop neutralizing antibodies to these vaccines. The addition of zinc compounds to the vaccines resulted in protection in cattle. The basis for the use of zinc is discussed. A mutant based vaccine was effective following local administration, but was not when administered parenterally. Anti-prostaglandin was not effective either, despite its successful use in sheep when administered with BHV1. The vaccine presents a prospect for immunising dogs and cats, and the addition of zinc compounds to other drugs and inducers is discussed.
Straub
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Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D011557:Pseudorabies / Q000517:prevention & control*; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D015032:Zinc
D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D015032:Zinc
Entwicklung eines inaktivierten Impfstoffs zum Schutz der Rinder vor Aujeszkyscher Krankheit.