Absence of circulating antineutrophil cytoplasm antibodies (ANCA) in severe vasculitis associated with rheumatoid arthritis.
Sixteen patients with classical rheumatoid arthritis (RA) complicated by severe vasculitis were studied and compared with a matched control group of 17 RA patients without vasculitis. A control group of 24 patients with unrelated disease was also included. Neither antineutrophil cytoplasmic antibodies (C-ANCA) nor anti-myeloperoxidase (anti-MPO) were found. Granulocyte specific antinuclear antibodies ("GS-ANA") were found in a higher frequency in the vasculitis group (75%) than in the RA control group (41%), but the difference was not statistically significant. No patient in the control group without RA had "GS-ANA".
Nässberger
L
L
Department of Medical Microbiology, University of Lund, Sweden.
Sjöholm
A G
AG
Sturfelt
G
G
D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000150:complications*; D003593:Cytoplasm / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology; D014657:Vasculitis / Q000209:etiology / Q000276:immunology*
D000906:Antibodies; D009195:Peroxidase