Transporting of sodium and calcium cation in erythrocyte in patients with essential hypertension.
The sodium and calcium cation transport in erythrocyte and their influencing factors were studied in essential hypertensive (EH) patients. The result showed that plasma sodium pump inhibitor, endogenous digitalis-like compound (EDLC), rose in some patients and sodium pump was depressed in the others, but there were no parallel links between EDLC and sodium pump. The patients with normal sodium pump have mainly shown a decrease of their maximal CA++ pump activity and calmodulin (CaM) content in erythrocyte. It indicated that there might be different types of ion transporting defect in EH, and the abnormalities of these cation transports might be an important pathogenesis in EH.
Zhu
Z M
ZM
Hypertension Laboratory, Third Affiliated Hospital, Chongqing.
Song
K Q
KQ
Liu
G Y
GY
Li
Y R
YR
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002147:Calmodulin / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002147:Calmodulin; D012964:Sodium; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium