The effect of toluene on the vestibulo- and opto-oculomotor system in rats, pretreated with GABAergic drugs.
Toluene, an aromatic solvent, prolongs the duration of nystagmus induced by a rotatory acceleration or by an optokinetic stimulation in the pigmented rat. Baclofen, an agonist of GABAB receptors, and 4,5,6,7-tetrahydroisoxazolo[5,4-c]-pyridin-3-ol (THIP), an agonist of GABAA receptors are able to block this toluene effect on the vestibular system. On the contrary diazepam, which by itself causes an evident reduction of the duration of acceleratory nystagmus, is not able to block the toluene effect. The results indicate that the toluene effect is related to GABA transmission and that the solvent interacts by a rather receptor specific mechanism of action.
Tham
R
R
Department of Otolaryngology, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Larsby
B
B
Eriksson
B
B
Niklasson
M
M
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D007555:Isoxazoles / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009760:Nystagmus, Physiologic / Q000187:drug effects / Q000502:physiology; D009802:Oculomotor Nerve / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014050:Toluene / Q000633:toxicity*; D014726:Vestibular Nuclei / Q000187:drug effects* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D007555:Isoxazoles; D011963:Receptors, GABA-A; D014050:Toluene; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; C015542:gaboxadol; D003975:Diazepam