title: Proton-nuclear magnetic resonance relaxation times in brain edema.
abstract: Proton relaxation times of protein solutions, bovine brain, and edematous feline brain tissue were studied as a function of water concentration, protein concentration, and temperature. In accordance with the fast proton exchange model for relaxation, a linear relation could be established between R1 and the inverse of the weight fraction of tissue water. This relation also applied to R2 of gray matter and of protein solutions. No straightforward relation with water content was found for R2 of white matter. Temperature-dependent studies indicated that in this case, the slow exchange model for relaxation had to be applied. The effect of macromolecules in physiological relevant concentrations on the total relaxation behavior of edematous tissue was weak. Total water content changes predominantly affected the relaxation rates. The linear relation may have high clinical potential for assessment of the status of cerebral edema on the basis of T1 and T2 readings from MR images.
authors.affiliation: Department of Physical Chemistry, University of Groningen, The Netherlands.
authors.forename: R L
authors.initials: RL
authors.lastname: Kamman
authors.forename: K G
authors.initials: KG
authors.lastname: Go
authors.forename: H J
authors.initials: HJ
authors.lastname: Berendsen
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D001930:Brain Injuries / Q000150:complications; D002415:Cats; D002417:Cattle; D003080:Cold Temperature / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011522:Protons
chemical_list: D011522:Protons