title: [Optimization of gadolinium-DTPA dose: an inter-individual study of patients with intracranial tumors].
abstract: The diagnostic value of various doses of Gd-DTPA was compared intra-individually. Thirty-three patients with cerebral tumours were randomly allocated to three groups. Group 1 was given a dose of 0.025, group 2 a dose of 0.05 and group 3 a dose of 0.1 mmol GD-DTPA/kg body weight. Following administration of Gd-DTPA the average tumor/brain contrast in group 1 was -4.5%, in group 2 +8.4% and in group 3 +43.0%. Diagnostically useful tumour delineation was obtained in two out of 11 in group 1, in seven out of 11 in group 2 and in 10 out of 11 in group 3. A further increase in the dose to 0.2 mmol/kg body weight in group 3 resulted in a further increase in tumour/brain contrast of +62.5% and improved tumour delineation in one case. As a result of these findings a dose of 0.1 mmol Gd-DTPA/kg body weight is recommended for the routine investigation of intracranial tumours.
authors.affiliation: Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow/Standort Charlottenburg.
authors.forename: P
authors.initials: P
authors.lastname: Schubeus
authors.forename: W
authors.initials: W
authors.lastname: Schörner
authors.forename: J
authors.initials: J
authors.lastname: Haustein
authors.forename: N
authors.initials: N
authors.lastname: Hosten
authors.forename: H P
authors.initials: HP
authors.lastname: Niendorf
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
vernacular_title: Dosisoptimierung von Gadolinium-DTPA: Eine interindividuelle Studie an Patienten mit intrakraniellen Tumoren.