Induction of ornithine decarboxylase by subseizure stimulation in the hippocampus in vivo.
Electrical stimulation of the Schaffer-collateral axonal system under conditions which do not elicit detectable seizure activity causes an increase in the activity of ornithine decarboxylase (ODC), the rate limiting enzyme of polyamine synthesis, in the hippocampus, olfactory cortex, neocortex and olfactory bulb. The degree of ODC activation is dependent upon the stimulus parameters. The results support the hypothesis that neuronal activity regulates hippocampal polyamine concentrations.
Arai
A
A
Center for Neurobiology of Learning and Memory, University of California, Irvine 92717.
Baudry
M
M
Staubli
U
U
Lynch
G
G
Gall
C
C
D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000201:enzymology* / Q000502:physiology; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009955:Ornithine Decarboxylase