title: Respiratory response and pharmacokinetics of intravenous salbutamol in infants with bronchopulmonary dysplasia.
abstract: The effects of iv salbutamol on respiratory mechanics were studied in six infants with bronchopulmonary dysplasia. Salbutamol was infused at a dose of 30 micrograms/kg over 30 min in five infants; a sixth infant received 66.7 micrograms/kg over 4 min. Salbutamol caused improvement in total respiratory system compliance and in airflow resistance. There was no correlation between salbutamol serum concentration and pulmonary function. Elimination half-time appears to be dictated in these infants more by the distribution volume (Vd) than by clearance (Cl). The area under concentration-time curve of salbutamol correlated inversely to the change in heart rate (HR). There was a significant positive correlation between Vd and percent HR change. These data provide evidence that preterm infants have measurable activity of bronchiolar beta 2 receptor responsive to salbutamol.
authors.affiliation: Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Kirpalani
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: R
authors.initials: R
authors.lastname: Santos
authors.forename: S
authors.initials: S
authors.lastname: Soldin
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008170:Lung Compliance / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D012119:Respiration / Q000187:drug effects*
chemical_list: D011943:Receptors, Adrenergic, beta; D000420:Albuterol