Emergence of aminoglycoside resistance genes aadA and aadE in the genus Campylobacter.
Resistance to streptomycin or spectinomycin or both in five Campylobacter coli strains, two Campylobacter jejuni strains, and a Campylobacter-like strain was studied by enzymatic assays and dot blot hybridization. Resistance was due to 6- or 3",9-aminoglycoside adenylyltransferases and to new types of phospho- and adenylyltransferases.
Pinto-Alphandary
H
H
Unité des Agents Antibactériens, Institut Pasteur, Paris, France.
Mabilat
C
C
Courvalin
P
P
D002167:Campylobacter / Q000187:drug effects / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D009693:Nucleic Acid Hybridization; D009713:Nucleotidyltransferases / Q000235:genetics; D000198:Spectinomycin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*
D004269:DNA, Bacterial; D000198:Spectinomycin; D009713:Nucleotidyltransferases; C020658:glutamine-synthetase adenylyltransferase; D013307:Streptomycin